               SEQUENCE LISTING

<110> Clariant Produkte (Deutschland) GmbH

<120> Optimized 3-phytase and its use in food or feed production

<130> 2018DE612-WO-PCT

<160> 47

<170> BiSSAP 1.3.6

<210> 1
<211> 409
<212> PRT
<213> Artificial Sequence


<220> 
<223> Variant of wt Sequence (Seq2)

<400> 1
Asp Thr Pro Ser Ser Gly Trp Thr Leu Glu Lys Val Val Glu Val Ser 
1               5                   10                  15      
Arg His Gly Val Arg Pro Pro Thr Glu Asn Asn Val Lys Thr Ile Gln 
            20                  25                  30          
Glu Gly Thr Asn Arg Gln Trp Pro Thr Trp Leu Thr Gln Tyr Gly Glu 
        35                  40                  45              
Leu Thr Gly His Gly Tyr Ala Ala Ala Val Leu Lys Gly His Tyr Glu 
    50                  55                  60                  
Gly Gln Tyr Leu Arg Gln His Gly Leu Leu Cys Gln Ala Cys Pro Ala 
65                  70                  75                  80  
Pro Gly Asp Val Phe Val Trp Ala Ser Pro Leu Gln Arg Thr Arg Glu 
                85                  90                  95      
Thr Ala Met Ala Leu Met Asp Gly Val Phe Ser Gly Cys Gly Val Ala 
            100                 105                 110         
Ile Gln Gly Pro Glu Asp Glu Asp Asn Asp Pro Leu Phe His Ala Glu 
        115                 120                 125             
Lys Ala Gly Val Thr Leu Asp Gln Gln Gln Val Lys Ala Asp Leu Gln 
    130                 135                 140                 
Asn Ala Met Gln Asn Lys Ser Ala Ala Gln Ile Gln Ala Gln Trp Gln 
145                 150                 155                 160 
Pro Ala Ile Asp Arg Leu Lys Gln Ala Val Cys Leu Pro Asp Lys Pro 
                165                 170                 175     
Cys Pro Ala Phe Ser Thr Pro Trp Glu Val Lys Glu Asp Asn Asn Gly 
            180                 185                 190         
Arg Ile Tyr Leu His Gly Pro Glu Val Leu Ala Asn Ile Ala Glu Thr 
        195                 200                 205             
Ile Gln Met Ser Tyr Ser Asn Asn Asn Pro Leu Ser Glu Val Ala Phe 
    210                 215                 220                 
Gly His Ala Lys Thr Ala Ala Glu Val Ala Ala Leu Met Pro Leu Leu 
225                 230                 235                 240 
Thr Ala Lys Tyr Asp Phe Thr Asn Asp Leu Pro Tyr Val Ala Arg Arg 
                245                 250                 255     
Gly Ala Ser Val Leu Met Asn Gln Ile Ala Leu Ala Leu Asn Thr Glu 
            260                 265                 270         
His Gln Ala Asp Ala Pro Pro Asp Ala Lys Trp Leu Leu Tyr Val Ala 
        275                 280                 285             
His Asp Thr Asn Ile Ala Tyr Leu Arg Thr Met Leu Gly Phe Thr Trp 
    290                 295                 300                 
Gln Met Gly Asp Tyr Pro Arg Gly Asn Ile Pro Pro Ala Gly Ser Leu 
305                 310                 315                 320 
Ile Phe Glu Arg Trp Arg Asn Gln Gln Ser Gly Gln Arg Val Val Arg 
                325                 330                 335     
Ile Tyr Phe Gln Ala Gln Ser Leu Asp Gln Ile Arg Gly Leu Ala Ala 
            340                 345                 350         
Leu Asp Asp Ser His Pro Pro Leu Arg Ser Glu Phe Ser Met Pro Asp 
        355                 360                 365             
Cys Gln Lys Thr Asp Ile Gly Thr Leu Cys Pro Tyr Asp Ala Val Met 
    370                 375                 380                 
Lys Arg Leu Asn Asp Ala Val Asp Arg Thr Ala Leu Leu Pro Val His 
385                 390                 395                 400 
Tyr Thr Pro His His His His His His 
                405                 

<210> 2
<211> 409
<212> PRT
<213> Artificial Sequence


<220> 
<223> wt sequence of Dickeya zeae phytase with His tag

<400> 2
Asp Thr Pro Ser Ser Gly Trp Thr Leu Glu Lys Val Val Glu Val Ser 
1               5                   10                  15      
Arg His Gly Val Arg Pro Pro Thr Lys Gly Asn Val Lys Thr Ile Gln 
            20                  25                  30          
Glu Gly Thr Asp Arg Gln Trp Pro Thr Trp Leu Thr Gln Tyr Gly Glu 
        35                  40                  45              
Leu Thr Gly His Gly Tyr Ala Ala Ala Val Leu Lys Gly His Tyr Glu 
    50                  55                  60                  
Gly Gln Tyr Leu Arg Gln His Gly Leu Leu Ser Gln Ala Cys Pro Ala 
65                  70                  75                  80  
Pro Gly Asp Val Phe Val Trp Ala Ser Pro Leu Gln Arg Thr Arg Glu 
                85                  90                  95      
Thr Ala Met Ala Leu Met Asp Gly Val Phe Pro Gly Cys Gly Val Ala 
            100                 105                 110         
Ile Gln Gly Pro Glu Asp Glu Asp Asn Asp Pro Leu Phe His Ala Glu 
        115                 120                 125             
Thr Ala Gly Val Thr Leu Asp Gln Gln Gln Val Lys Ala Asp Leu Gln 
    130                 135                 140                 
Asn Ala Met Gln Asp Lys Ser Ala Ala Gln Ile Gln Ala Gln Trp Gln 
145                 150                 155                 160 
Pro Ala Ile Asp Arg Leu Lys Gln Ala Val Cys Leu Pro Asp Lys Pro 
                165                 170                 175     
Cys Pro Ala Phe Ser Thr Pro Trp Glu Val Lys Glu Ser Lys Lys Gly 
            180                 185                 190         
Asn Ile Ser Leu His Gly Pro Glu Val Leu Ala Asn Ile Ala Glu Thr 
        195                 200                 205             
Ile Arg Leu Ser Tyr Ser Asn Asn Asn Pro Leu Ser Glu Val Ala Phe 
    210                 215                 220                 
Gly His Ala Lys Thr Ala Ala Glu Val Ala Ala Leu Met Pro Leu Leu 
225                 230                 235                 240 
Thr Ala Asn Tyr Asp Phe Thr Asn Asp Leu Pro Tyr Val Ala Arg Arg 
                245                 250                 255     
Gly Ala Ser Val Leu Met Asn Gln Ile Ala Leu Ala Leu Asn Thr Glu 
            260                 265                 270         
His Gln Ala Asp Ala Pro Pro Asp Ala Lys Trp Leu Leu Tyr Val Ala 
        275                 280                 285             
His Asp Thr Asn Ile Ala Lys Leu Arg Thr Met Leu Gly Phe Thr Trp 
    290                 295                 300                 
Gln Met Gly Asp Tyr Pro Arg Gly Asn Ile Pro Pro Ala Gly Ser Leu 
305                 310                 315                 320 
Ile Phe Glu Arg Trp Arg Asn Gln Gln Ser Gly Gln Arg Val Val Arg 
                325                 330                 335     
Ile Tyr Phe Gln Ala Gln Ser Leu Asp Gln Ile Arg Gly Leu Ala Ala 
            340                 345                 350         
Leu Asp Asp Ser His Pro Pro Leu Arg Ser Glu Phe Ser Met Pro Asp 
        355                 360                 365             
Cys Gln Lys Thr Asp Ile Gly Thr Leu Cys Pro Tyr Asp Ala Val Met 
    370                 375                 380                 
Lys Arg Leu Asn Asp Ala Val Asp Arg Thr Ala Leu Leu Pro Val His 
385                 390                 395                 400 
Tyr Thr Pro His His His His His His 
                405                 

<210> 3
<211> 409
<212> PRT
<213> Artificial Sequence


<220> 
<223> Variant of wt sequence (Seq2)

<400> 3
Asp Thr Pro Ser Ser Gly Trp Thr Leu Glu Lys Val Val Glu Val Ser 
1               5                   10                  15      
Arg His Gly Val Arg Pro Pro Thr Glu Asn Asn Val Lys Thr Ile Gln 
            20                  25                  30          
Glu Gly Thr Asn Arg Gln Trp Pro Thr Trp Leu Thr Gln Tyr Gly Glu 
        35                  40                  45              
Leu Thr Gly His Gly Tyr Ala Ala Ala Val Leu Lys Gly His Tyr Glu 
    50                  55                  60                  
Gly Gln Tyr Leu Arg Gln His Gly Leu Leu Cys Gln Ala Cys Pro Ala 
65                  70                  75                  80  
Pro Gly Asp Val Phe Val Trp Ala Ser Pro Leu Gln Arg Thr Arg Glu 
                85                  90                  95      
Thr Ala Met Ala Leu Met Asp Gly Val Phe Pro Gly Cys Gly Val Ala 
            100                 105                 110         
Ile Gln Gly Pro Glu Asp Glu Asp Asn Asp Pro Leu Phe His Ala Glu 
        115                 120                 125             
Thr Ala Gly Val Thr Leu Asp Gln Gln Gln Val Lys Ala Asp Leu Gln 
    130                 135                 140                 
Asn Ala Met Gln Asn Lys Ser Ala Ala Gln Ile Gln Ala Gln Trp Gln 
145                 150                 155                 160 
Pro Ala Ile Asp Arg Leu Lys Gln Ala Val Cys Leu Pro Asp Lys Pro 
                165                 170                 175     
Cys Pro Ala Phe Ser Thr Pro Trp Glu Val Lys Glu Asp Asn Asn Gly 
            180                 185                 190         
Ser Ile Ser Leu His Gly Pro Glu Val Leu Ala Ile Ile Ala Glu Thr 
        195                 200                 205             
Ile Gln Met Ser Tyr Ser Asn Asn Asn Pro Leu Ser Glu Val Ala Phe 
    210                 215                 220                 
Gly His Ala Lys Thr Ala Ala Glu Val Ala Ala Leu Met Pro Leu Leu 
225                 230                 235                 240 
Thr Ala Asn Tyr Asp Phe Thr Asn Asp Leu Pro Tyr Val Ala Arg Arg 
                245                 250                 255     
Gly Ala Ser Val Leu Met Asn Gln Ile Ala Leu Ala Leu Asn Thr Glu 
            260                 265                 270         
His Gln Ala Asp Ala Pro Pro Asp Ala Lys Trp Leu Leu Tyr Val Ala 
        275                 280                 285             
His Asp Thr Asn Ile Ala Lys Leu Arg Thr Met Leu Gly Phe Thr Trp 
    290                 295                 300                 
Gln Met Gly Asp Tyr Pro Arg Gly Asn Ile Pro Pro Ala Gly Ser Leu 
305                 310                 315                 320 
Ile Phe Glu Arg Trp Arg Asn Gln Gln Ser Gly Gln Arg Val Val Arg 
                325                 330                 335     
Ile Tyr Phe Gln Ala Gln Ser Leu Asp Gln Ile Arg Gly Leu Ala Ala 
            340                 345                 350         
Leu Asp Asp Ser His Pro Pro Leu Arg Ser Glu Phe Ser Met Pro Asp 
        355                 360                 365             
Cys Gln Lys Thr Asp Ile Gly Thr Leu Cys Pro Tyr Asp Ala Met Met 
    370                 375                 380                 
Lys Arg Leu Asn Asp Ala Val Asp Arg Thr Ala Leu Leu Pro Val His 
385                 390                 395                 400 
Tyr Thr Pro His His His His His His 
                405                 

<210> 4
<211> 409
<212> PRT
<213> Artificial Sequence


<220> 
<223> Variant of wt sequence (Seq2)

<400> 4
Asp Thr Pro Ser Ser Gly Trp Thr Leu Glu Lys Val Val Glu Val Ser 
1               5                   10                  15      
Arg His Gly Val Arg Pro Pro Thr Glu Ser Asn Val Lys Thr Ile Gln 
            20                  25                  30          
Glu Gly Thr Asn Arg Gln Trp Pro Thr Trp Leu Thr Gln Tyr Gly Glu 
        35                  40                  45              
Leu Thr Gly His Gly Tyr Ala Ala Ala Val Leu Lys Gly His Tyr Glu 
    50                  55                  60                  
Gly Gln Tyr Leu Arg Gln His Gly Leu Leu Cys Gln Ala Cys Pro Ala 
65                  70                  75                  80  
Pro Gly Asp Val Phe Val Trp Ala Ser Pro Leu Gln Arg Thr Arg Glu 
                85                  90                  95      
Thr Ala Met Ala Leu Met Asp Gly Val Phe Pro Gly Cys Gly Val Ala 
            100                 105                 110         
Ile Gln Gly Pro Glu Asp Glu Asp Asn Asp Pro Leu Phe His Ala Glu 
        115                 120                 125             
Thr Ala Gly Val Thr Leu Asp Gln Gln Gln Val Lys Ala Asp Leu Gln 
    130                 135                 140                 
Asn Ala Met Gln Asn Lys Ser Ala Ala Gln Ile Gln Ala Gln Trp Gln 
145                 150                 155                 160 
Pro Ala Ile Asp Arg Leu Lys Gln Ala Val Cys Leu Pro Asp Lys Pro 
                165                 170                 175     
Cys Pro Ala Phe Ser Thr Pro Trp Glu Val Lys Glu Asp Asn Asn Gly 
            180                 185                 190         
Ser Ile Ser Leu His Gly Pro Glu Val Leu Ala Ile Ile Ala Glu Thr 
        195                 200                 205             
Ile Gln Met Ser Tyr Ser Asn Asn Asn Pro Leu Ser Glu Val Ala Phe 
    210                 215                 220                 
Gly His Ala Lys Thr Ala Ala Glu Val Ala Ala Leu Met Pro Leu Leu 
225                 230                 235                 240 
Thr Ala Asn Tyr Asp Phe Thr Asn Asp Leu Pro Tyr Val Ala Arg Arg 
                245                 250                 255     
Gly Ala Ser Val Leu Met Asn Gln Ile Ala Leu Ala Leu Asn Thr Glu 
            260                 265                 270         
His Gln Ala Asp Ala Pro Pro Asp Ala Lys Trp Leu Leu Tyr Val Ala 
        275                 280                 285             
His Asp Thr Asn Ile Ala Lys Leu Arg Thr Met Leu Gly Phe Thr Trp 
    290                 295                 300                 
Gln Met Gly Asp Tyr Pro Arg Gly Asn Ile Pro Pro Ala Gly Ser Leu 
305                 310                 315                 320 
Ile Phe Glu Arg Trp Arg Asn Gln Gln Ser Gly Gln Arg Val Val Arg 
                325                 330                 335     
Ile Tyr Phe Gln Ala Gln Ser Leu Asp Gln Ile Arg Gly Leu Ala Ala 
            340                 345                 350         
Leu Asp Asp Ser His Pro Pro Leu Arg Ser Glu Phe Ser Met Pro Asp 
        355                 360                 365             
Cys Gln Lys Thr Asp Ile Gly Thr Leu Cys Pro Tyr Asp Ala Val Met 
    370                 375                 380                 
Lys Arg Leu Asn Asp Ala Val Asp Arg Thr Ala Leu Leu Pro Val His 
385                 390                 395                 400 
Tyr Thr Pro His His His His His His 
                405                 

<210> 5
<211> 409
<212> PRT
<213> Artificial Sequence


<220> 
<223> Variant of wt sequence (Seq2)

<400> 5
Asp Thr Pro Ser Ser Gly Trp Thr Leu Glu Lys Val Val Glu Val Ser 
1               5                   10                  15      
Arg His Gly Val Arg Pro Pro Thr Glu Asn Asn Val Lys Thr Ile Gln 
            20                  25                  30          
Glu Gly Thr Asn Arg Gln Trp Pro Thr Trp Leu Thr Gln Tyr Gly Glu 
        35                  40                  45              
Leu Thr Gly His Gly Tyr Ala Ala Ala Val Leu Lys Gly His Tyr Glu 
    50                  55                  60                  
Gly Gln Tyr Leu Arg Gln His Gly Leu Leu Cys Gln Ala Cys Pro Ala 
65                  70                  75                  80  
Pro Gly Asp Val Phe Val Trp Ala Ser Pro Leu Gln Arg Thr Arg Glu 
                85                  90                  95      
Thr Ala Met Ala Leu Met Asp Gly Val Phe Ser Gly Cys Gly Val Ala 
            100                 105                 110         
Ile Gln Gly Pro Glu Asp Glu Asp Asn Asp Pro Leu Phe His Ala Glu 
        115                 120                 125             
Thr Ala Gly Val Thr Leu Asp Gln Gln Gln Val Lys Ala Asp Leu Gln 
    130                 135                 140                 
Asn Ala Met Gln Asn Lys Ser Ala Ala Gln Ile Gln Ala Gln Trp Gln 
145                 150                 155                 160 
Pro Ala Ile Asp Arg Leu Lys Gln Ala Val Cys Leu Pro Asp Lys Pro 
                165                 170                 175     
Cys Pro Ala Phe Ser Thr Pro Trp Glu Val Lys Glu Asp Asn Asn Gly 
            180                 185                 190         
Ser Ile Ser Leu His Gly Pro Glu Val Leu Ala Ile Ile Ala Glu Thr 
        195                 200                 205             
Ile Gln Met Ser Tyr Ser Asn Asn Asn Pro Leu Ser Glu Val Ala Phe 
    210                 215                 220                 
Gly His Ala Lys Thr Ala Ala Glu Val Ala Ala Leu Met Pro Leu Leu 
225                 230                 235                 240 
Thr Ala Asn Tyr Asp Phe Thr Asn Asp Leu Pro Tyr Val Ala Arg Arg 
                245                 250                 255     
Gly Ala Ser Val Leu Met Asn Gln Ile Ala Leu Ala Leu Asn Thr Glu 
            260                 265                 270         
His Gln Ala Asp Ala Pro Pro Asp Ala Lys Trp Leu Leu Tyr Val Ala 
        275                 280                 285             
His Asp Thr Asn Ile Ala Lys Leu Arg Thr Met Leu Gly Phe Thr Trp 
    290                 295                 300                 
Gln Met Gly Asp Tyr Pro Arg Gly Asn Ile Pro Pro Ala Gly Ser Leu 
305                 310                 315                 320 
Ile Phe Glu Arg Trp Arg Asn Gln Gln Ser Gly Gln Arg Val Val Arg 
                325                 330                 335     
Ile Tyr Phe Gln Ala Gln Ser Leu Asp Gln Ile Arg Gly Leu Ala Ala 
            340                 345                 350         
Leu Asp Asp Ser His Pro Pro Leu Arg Ser Glu Phe Ser Met Pro Asp 
        355                 360                 365             
Cys Gln Lys Thr Asp Ile Gly Thr Leu Cys Pro Tyr Asp Ala Val Met 
    370                 375                 380                 
Lys Arg Leu Asn Asp Ala Val Asp Arg Thr Ala Leu Leu Pro Val His 
385                 390                 395                 400 
Tyr Thr Pro His His His His His His 
                405                 

<210> 6
<211> 409
<212> PRT
<213> Artificial Sequence


<220> 
<223> Variant of wt sequence (Seq2)

<400> 6
Asp Thr Pro Ser Ser Gly Trp Thr Leu Glu Lys Val Val Glu Val Ser 
1               5                   10                  15      
Arg His Gly Val Arg Pro Pro Thr Glu Ser Asn Val Lys Thr Ile Gln 
            20                  25                  30          
Glu Gly Thr Asp Arg Gln Trp Pro Thr Trp Leu Thr Arg Tyr Gly Glu 
        35                  40                  45              
Leu Thr Gly His Gly Tyr Ala Ala Ala Val Leu Lys Gly His Tyr Glu 
    50                  55                  60                  
Gly Gln Tyr Leu Arg Gln His Gly Leu Leu Cys Gln Ala Cys Pro Ala 
65                  70                  75                  80  
Pro Gly Asp Val Phe Val Trp Ala Ser Pro Leu Gln Arg Thr Arg Glu 
                85                  90                  95      
Thr Ala Met Ala Leu Met Asp Gly Val Phe Pro Gly Cys Gly Val Ala 
            100                 105                 110         
Ile Gln Gly Pro Glu Asp Glu Asp Asn Asp Pro Leu Phe His Ala Glu 
        115                 120                 125             
Thr Ala Gly Val Thr Leu Asp Gln Gln Gln Val Lys Ala Asp Leu Gln 
    130                 135                 140                 
Asn Ala Met Gln Asn Lys Ser Ala Ala Gln Ile Gln Ala Gln Trp Gln 
145                 150                 155                 160 
Pro Ala Ile Asp Arg Leu Lys Gln Ala Val Cys Leu Pro Asp Lys Pro 
                165                 170                 175     
Cys Pro Ala Phe Ser Thr Pro Trp Glu Val Lys Glu Asp Asn Asn Gly 
            180                 185                 190         
Ser Ile Ser Leu His Gly Pro Glu Val Leu Ala Ile Ile Ala Glu Thr 
        195                 200                 205             
Ile Gln Met Ser Tyr Ser Asn Asn Asn Pro Leu Ser Glu Val Ala Phe 
    210                 215                 220                 
Gly His Ala Lys Thr Ala Ala Glu Val Ala Ala Leu Met Pro Leu Leu 
225                 230                 235                 240 
Thr Ala Asn Tyr Asp Phe Thr Asn Asp Leu Pro Tyr Val Ala Arg Arg 
                245                 250                 255     
Gly Ala Ser Val Leu Met Asn Gln Ile Ala Leu Ala Leu Asn Thr Glu 
            260                 265                 270         
His Gln Ala Asp Ala Pro Pro Asp Ala Lys Trp Leu Leu Tyr Val Ala 
        275                 280                 285             
His Asp Thr Asn Ile Ala Lys Leu Arg Thr Met Leu Gly Phe Thr Trp 
    290                 295                 300                 
Gln Met Gly Asp Tyr Pro Arg Gly Asn Ile Pro Pro Ala Gly Ser Leu 
305                 310                 315                 320 
Ile Phe Glu Arg Trp Arg Asn Gln Gln Ser Gly Gln Arg Val Val Arg 
                325                 330                 335     
Ile Tyr Phe Gln Ala Gln Ser Leu Asp Gln Ile Arg Gly Leu Ala Ala 
            340                 345                 350         
Leu Asp Asp Ser His Pro Pro Leu Arg Ser Glu Phe Ser Met Pro Asp 
        355                 360                 365             
Cys Gln Lys Thr Asp Ile Gly Thr Leu Cys Pro Tyr Asp Ala Val Met 
    370                 375                 380                 
Lys Arg Leu Asn Asp Ala Val Asp Arg Thr Ala Leu Leu Pro Val His 
385                 390                 395                 400 
Tyr Thr Pro His His His His His His 
                405                 

<210> 7
<211> 409
<212> PRT
<213> Artificial Sequence


<220> 
<223> Variant of wt sequence (Seq2)

<400> 7
Asp Thr Pro Ser Ser Gly Trp Thr Leu Glu Lys Val Val Glu Val Ser 
1               5                   10                  15      
Arg His Gly Val Arg Pro Pro Thr Glu Ser Asn Val Lys Thr Ile Gln 
            20                  25                  30          
Glu Gly Thr Asp Arg Gln Trp Pro Thr Trp Leu Thr Gln Tyr Gly Glu 
        35                  40                  45              
Leu Thr Gly His Gly Tyr Ala Ala Ala Val Leu Lys Gly His Tyr Glu 
    50                  55                  60                  
Gly Gln Tyr Leu Arg Gln His Gly Leu Leu Cys Gln Ala Cys Pro Ala 
65                  70                  75                  80  
Pro Gly Asp Val Phe Val Trp Ala Ser Pro Leu Gln Arg Thr Arg Glu 
                85                  90                  95      
Thr Ala Met Ala Leu Met Asp Gly Val Phe Pro Gly Cys Gly Val Ala 
            100                 105                 110         
Ile Gln Gly Pro Glu Asp Glu Asp Asn Asp Pro Leu Phe His Ala Glu 
        115                 120                 125             
Thr Ala Gly Val Thr Leu Asp Gln Gln Gln Val Lys Ala Asp Leu Leu 
    130                 135                 140                 
Asn Ala Met Gln Asn Lys Ser Ala Ala Gln Ile Gln Ala Gln Trp Gln 
145                 150                 155                 160 
Pro Ala Ile Asp Arg Leu Lys Gln Ala Val Cys Leu Pro Asp Lys Pro 
                165                 170                 175     
Cys Pro Ala Phe Ser Thr Pro Trp Glu Val Lys Glu Asp Asn Asn Gly 
            180                 185                 190         
Ser Ile Ser Leu His Gly Pro Glu Val Leu Ala Ile Ile Ala Glu Thr 
        195                 200                 205             
Ile Gln Met Ser Tyr Ser Asn Asn Asn Pro Leu Ser Glu Val Ala Phe 
    210                 215                 220                 
Gly His Ala Lys Thr Ala Ala Glu Val Ala Ala Leu Met Pro Leu Leu 
225                 230                 235                 240 
Thr Ala Asn Tyr Asp Phe Thr Asn Asp Leu Pro Tyr Val Ala Arg Arg 
                245                 250                 255     
Gly Ala Ser Val Leu Met Asn Gln Ile Ala Leu Ala Leu Asn Thr Glu 
            260                 265                 270         
His Gln Ala Asp Ala Pro Pro Asp Ala Lys Trp Leu Leu Tyr Val Ala 
        275                 280                 285             
His Asp Thr Asn Ile Ala Lys Leu Arg Thr Met Leu Gly Phe Thr Trp 
    290                 295                 300                 
Gln Met Gly Asp Tyr Pro Arg Gly Asn Ile Pro Pro Ala Gly Ser Leu 
305                 310                 315                 320 
Ile Phe Glu Arg Trp Arg Asn Gln Gln Ser Gly Gln Arg Val Val Arg 
                325                 330                 335     
Ile Tyr Phe Gln Ala Gln Ser Leu Asp Gln Ile Arg Gly Leu Ala Ala 
            340                 345                 350         
Leu Asp Asp Ser His Pro Pro Leu Arg Ser Glu Phe Ser Met Pro Asp 
        355                 360                 365             
Cys Gln Lys Thr Asp Ile Gly Thr Leu Cys Pro Tyr Asp Ala Val Met 
    370                 375                 380                 
Lys Arg Leu Asn Asp Ala Val Asp Arg Thr Ala Leu Leu Pro Val His 
385                 390                 395                 400 
Tyr Thr Pro His His His His His His 
                405                 

<210> 8
<211> 409
<212> PRT
<213> Artificial Sequence


<220> 
<223> Variant of wt sequence (Seq2)

<400> 8
Asp Thr Pro Ser Ser Gly Trp Thr Leu Glu Lys Val Val Glu Val Ser 
1               5                   10                  15      
Arg His Gly Val Arg Pro Pro Thr Glu Ser Asn Val Lys Thr Ile Gln 
            20                  25                  30          
Glu Gly Thr Asn Arg Gln Trp Pro Thr Trp Leu Thr Gln Tyr Gly Glu 
        35                  40                  45              
Leu Thr Gly His Gly Tyr Ala Ala Ala Val Leu Lys Gly His Tyr Glu 
    50                  55                  60                  
Gly Gln Tyr Leu Arg Gln His Gly Leu Leu Cys Gln Ala Cys Pro Ala 
65                  70                  75                  80  
Pro Gly Asp Val Phe Val Trp Ala Ser Pro Leu Gln Arg Thr Arg Glu 
                85                  90                  95      
Thr Ala Met Ala Leu Met Asp Gly Val Phe Pro Gly Cys Gly Val Ala 
            100                 105                 110         
Ile Gln Gly Pro Glu Asp Glu Asp Asn Asp Pro Leu Phe His Ala Glu 
        115                 120                 125             
Thr Ala Gly Val Thr Leu Asp Gln Gln Gln Val Lys Ala Asp Leu Gln 
    130                 135                 140                 
Asn Ala Met Gln Asn Lys Ser Ala Ala Gln Ile Gln Ala Gln Trp Gln 
145                 150                 155                 160 
Pro Ala Ile Asp Arg Leu Lys Gln Ala Val Cys Leu Pro Asp Lys Pro 
                165                 170                 175     
Cys Pro Ala Phe Ser Thr Pro Trp Glu Val Lys Glu Asp Asn Asn Gly 
            180                 185                 190         
Ser Ile Ser Leu His Gly Pro Glu Val Leu Ala Ile Ile Ala Glu Thr 
        195                 200                 205             
Ile Gln Met Ser Tyr Ser Asn Asn Asn Pro Leu Ser Glu Val Ala Phe 
    210                 215                 220                 
Gly His Ala Lys Thr Ala Ala Glu Val Ala Ala Leu Met Pro Leu Leu 
225                 230                 235                 240 
Thr Ala Asn Tyr Asp Phe Thr Asn Asp Leu Pro Tyr Val Ala Arg Arg 
                245                 250                 255     
Gly Ala Ser Val Leu Met Asn Gln Ile Ala Leu Ala Leu Asn Thr Glu 
            260                 265                 270         
His Gln Ala Asp Ala Pro Pro Asp Ala Lys Trp Leu Leu Tyr Val Ala 
        275                 280                 285             
His Asp Thr Asn Ile Ala Lys Leu Arg Thr Met Leu Gly Phe Thr Trp 
    290                 295                 300                 
Gln Met Gly Asp Tyr Pro Arg Gly Asn Ile Pro Pro Ala Gly Ser Leu 
305                 310                 315                 320 
Ile Phe Glu Arg Trp Arg Asn Gln Gln Ser Gly Gln Arg Val Val Arg 
                325                 330                 335     
Ile Tyr Phe Gln Ala Gln Ser Leu Asp Gln Ile Arg Gly Leu Ala Ala 
            340                 345                 350         
Leu Asp Asp Ser His Pro Pro Leu Arg Ser Glu Phe Ser Met Pro Asp 
        355                 360                 365             
Cys Gln Lys Thr Asp Ile Gly Thr Leu Cys Pro Tyr Asp Ala Val Met 
    370                 375                 380                 
Lys Arg Leu Asn Asp Ala Val Asp His Thr Ala Leu Leu Pro Val His 
385                 390                 395                 400 
Tyr Thr Pro His His His His His His 
                405                 

<210> 9
<211> 409
<212> PRT
<213> Artificial Sequence


<220> 
<223> Variant of wt sequence (Seq2)

<400> 9
Asp Thr Pro Ser Ser Gly Trp Thr Leu Glu Lys Val Val Glu Val Ser 
1               5                   10                  15      
Arg His Gly Val Arg Pro Pro Thr Glu Ser Asn Val Lys Thr Ile Gln 
            20                  25                  30          
Glu Gly Thr Asp Arg Gln Trp Pro Thr Trp Leu Thr Gln Tyr Gly Glu 
        35                  40                  45              
Leu Thr Gly His Gly Tyr Ala Ala Ala Val Leu Lys Gly His Tyr Glu 
    50                  55                  60                  
Gly Gln Tyr Leu Arg Gln His Gly Leu Leu Ser Gln Ala Cys Pro Ala 
65                  70                  75                  80  
Pro Gly Asp Val Phe Val Trp Ala Ser Pro Leu Gln Arg Thr Arg Glu 
                85                  90                  95      
Thr Ala Met Ala Leu Met Asp Gly Val Phe Pro Gly Cys Gly Val Ala 
            100                 105                 110         
Ile Gln Gly Pro Glu Asp Glu Asp Asn Asp Pro Leu Phe His Ala Glu 
        115                 120                 125             
Lys Ala Gly Val Thr Leu Asp Gln Gln Gln Val Lys Ala Asp Leu Gln 
    130                 135                 140                 
Asn Ala Met Gln Asn Lys Ser Ala Ala Gln Ile Gln Ala Gln Trp Gln 
145                 150                 155                 160 
Pro Ala Ile Asp Arg Leu Lys Gln Ala Val Cys Leu Pro Asp Lys Pro 
                165                 170                 175     
Cys Pro Ala Phe Ser Thr Pro Trp Glu Val Lys Glu Asp Asn Asn Gly 
            180                 185                 190         
Ser Ile Ser Leu His Gly Pro Glu Val Leu Ala Ile Ile Ala Glu Thr 
        195                 200                 205             
Ile Gln Met Ser Tyr Ser Asn Asn Asn Pro Leu Ser Glu Val Ala Phe 
    210                 215                 220                 
Gly His Ala Lys Thr Ala Ala Glu Val Ala Ala Leu Met Pro Leu Leu 
225                 230                 235                 240 
Thr Ala Asn Tyr Asp Phe Thr Asn Asp Leu Pro Tyr Val Ala Arg Arg 
                245                 250                 255     
Gly Ala Ser Val Leu Met Asn Gln Ile Ala Leu Ala Leu Asn Thr Glu 
            260                 265                 270         
His Gln Ala Asp Ala Pro Pro Asp Ala Lys Trp Leu Leu Tyr Val Ala 
        275                 280                 285             
His Asp Thr Asn Ile Ala Lys Leu Arg Thr Met Leu Gly Phe Thr Trp 
    290                 295                 300                 
Gln Met Gly Asp Tyr Pro Arg Gly Asn Ile Pro Pro Ala Gly Ser Leu 
305                 310                 315                 320 
Ile Phe Glu Arg Trp Arg Asn Gln Gln Ser Gly Gln Arg Val Val Arg 
                325                 330                 335     
Ile Tyr Phe Gln Ala Gln Ser Leu Asp Gln Ile Arg Gly Leu Ala Ala 
            340                 345                 350         
Leu Asp Asp Ser His Pro Pro Leu Arg Ser Glu Phe Ser Met Pro Asp 
        355                 360                 365             
Cys Gln Lys Thr Asp Ile Gly Thr Leu Cys Pro Tyr Asp Ala Val Met 
    370                 375                 380                 
Lys Arg Leu Asn Asp Ala Val Asp Arg Thr Ala Leu Leu Pro Val His 
385                 390                 395                 400 
Tyr Thr Pro His His His His His His 
                405                 

<210> 10
<211> 409
<212> PRT
<213> Artificial Sequence


<220> 
<223> Variant of wt sequence (Seq2)

<400> 10
Asp Thr Pro Ser Ser Gly Trp Thr Leu Glu Lys Val Val Glu Val Ser 
1               5                   10                  15      
Arg His Gly Val Arg Pro Pro Thr Glu Ser Asn Val Lys Thr Ile Gln 
            20                  25                  30          
Glu Gly Thr Asp Arg Gln Trp Pro Thr Trp Leu Thr Gln Tyr Gly Glu 
        35                  40                  45              
Leu Thr Gly His Gly Tyr Ala Ala Ala Val Leu Lys Gly His Tyr Glu 
    50                  55                  60                  
Gly Gln Tyr Leu Arg Gln His Gly Leu Leu Cys Arg Ala Cys Pro Ala 
65                  70                  75                  80  
Pro Gly Asp Val Phe Val Trp Ala Ser Pro Leu Gln Arg Thr Arg Glu 
                85                  90                  95      
Thr Ala Met Ala Leu Met Asp Gly Val Phe Pro Gly Cys Gly Val Ala 
            100                 105                 110         
Ile Gln Gly Pro Glu Asp Glu Asp Asn Asp Pro Leu Phe His Ala Glu 
        115                 120                 125             
Thr Ala Gly Val Thr Leu Asp Arg Gln Gln Val Lys Ala Asp Leu Gln 
    130                 135                 140                 
Asn Ala Met Gln Asn Lys Ser Ala Ala Gln Ile Gln Ala Gln Trp Gln 
145                 150                 155                 160 
Pro Ala Ile Asp Arg Leu Lys Gln Ala Val Cys Leu Pro Asp Lys Pro 
                165                 170                 175     
Cys Pro Ala Phe Ser Thr Pro Trp Glu Val Lys Glu Asp Asn Asn Gly 
            180                 185                 190         
Ser Ile Ser Leu His Gly Pro Glu Val Leu Ala Thr Ile Ala Glu Thr 
        195                 200                 205             
Ile Gln Met Ser Tyr Ser Asn Asn Asn Pro Leu Ser Glu Val Ala Phe 
    210                 215                 220                 
Gly His Ala Lys Thr Ala Ala Glu Val Ala Ala Leu Met Pro Leu Leu 
225                 230                 235                 240 
Thr Ala Asn Tyr Asp Tyr Thr Asn Asp Leu Pro Tyr Val Ala Arg Arg 
                245                 250                 255     
Gly Ala Ser Val Leu Met Asn Gln Ile Ala Leu Ala Leu Asn Thr Glu 
            260                 265                 270         
His Gln Ala Asp Ala Pro Pro Asp Ala Lys Trp Leu Leu Tyr Val Ala 
        275                 280                 285             
His Asp Thr Asn Ile Ala Lys Leu Arg Thr Met Leu Gly Phe Thr Trp 
    290                 295                 300                 
Gln Met Gly Asp Tyr Pro Arg Gly Asn Ile Pro Pro Ala Gly Ser Leu 
305                 310                 315                 320 
Ile Phe Glu Arg Trp Arg Asn Gln Gln Ser Gly Gln Arg Val Val Arg 
                325                 330                 335     
Ile Tyr Phe Gln Ala Gln Ser Leu Asp Gln Ile Arg Gly Leu Ala Ala 
            340                 345                 350         
Leu Asp Asp Ser His Pro Pro Leu Arg Ser Glu Phe Ser Met Pro Asp 
        355                 360                 365             
Cys Gln Lys Thr Asp Ile Gly Thr Leu Cys Pro Tyr Asp Ala Val Met 
    370                 375                 380                 
Lys Arg Leu Asn Asp Ala Val Asp Arg Thr Ala Leu Leu Pro Val His 
385                 390                 395                 400 
Tyr Thr Pro His His His His His His 
                405                 

<210> 11
<211> 409
<212> PRT
<213> Artificial Sequence


<220> 
<223> Variant of wt sequence (Seq2)

<400> 11
Asp Thr Pro Ser Ser Gly Trp Thr Leu Glu Lys Val Val Glu Val Ser 
1               5                   10                  15      
Arg His Gly Val Arg Pro Pro Thr Glu Ser Asn Val Lys Thr Ile Gln 
            20                  25                  30          
Glu Gly Thr Asp Arg Gln Trp Pro Thr Trp Leu Thr Gln Tyr Gly Glu 
        35                  40                  45              
Leu Thr Gly His Gly Tyr Ala Ala Ala Val Leu Lys Gly His Tyr Glu 
    50                  55                  60                  
Gly Gln Tyr Leu Arg Gln His Gly Leu Leu Cys Gln Ala Cys Pro Ala 
65                  70                  75                  80  
Pro Gly Asp Val Phe Val Trp Ala Ser Pro Leu Gln Arg Thr Arg Glu 
                85                  90                  95      
Thr Ala Met Ala Leu Met Asp Gly Val Phe Pro Gly Cys Gly Val Ala 
            100                 105                 110         
Ile Gln Gly Pro Glu Asp Glu Asp Asn Asp Pro Leu Phe His Ala Glu 
        115                 120                 125             
Thr Ala Gly Val Thr Leu Asp Gln Gln Gln Val Lys Ala Asp Leu Gln 
    130                 135                 140                 
Asn Ala Met Gln Asn Lys Ser Ala Ala Gln Ile Gln Ala Gln Trp Gln 
145                 150                 155                 160 
Pro Ala Ile Asp Arg Leu Lys Gln Ala Val Cys Leu Pro Asp Lys Pro 
                165                 170                 175     
Cys Pro Ala Phe Ser Thr Pro Trp Glu Val Lys Glu Asp Asn Asn Arg 
            180                 185                 190         
Ser Ile Ser Leu His Gly Pro Glu Val Leu Ala Ile Ile Ala Glu Thr 
        195                 200                 205             
Ile Gln Met Ser Tyr Ser Asn Asn Asn Pro Leu Ser Glu Val Ala Phe 
    210                 215                 220                 
Gly His Ala Lys Thr Ala Ala Glu Val Ala Ala Leu Met Pro Leu Leu 
225                 230                 235                 240 
Thr Ala Asn Tyr Asp Phe Thr Asn Asp Leu Pro Tyr Val Ala Arg Arg 
                245                 250                 255     
Gly Ala Ser Val Leu Met Asn Gln Ile Ala Leu Ala Leu Asn Thr Glu 
            260                 265                 270         
His Gln Ala Asp Ala Pro Pro Asp Ala Lys Trp Leu Leu Tyr Val Ala 
        275                 280                 285             
His Asp Thr Asn Ile Ala Lys Leu Arg Thr Met Leu Gly Phe Thr Trp 
    290                 295                 300                 
Gln Met Gly Asp Tyr Pro Arg Gly Asn Ile Pro Pro Ala Gly Ser Leu 
305                 310                 315                 320 
Ile Phe Glu Arg Trp Arg Asn Gln Gln Ser Gly Gln Arg Val Val Arg 
                325                 330                 335     
Ile Tyr Phe Gln Ala Gln Ser Leu Asp Gln Ile Arg Gly Leu Ala Ala 
            340                 345                 350         
Leu Asp Asp Ser His Pro Pro Leu Arg Ser Glu Phe Ser Met Pro Asp 
        355                 360                 365             
Cys Gln Lys Thr Asp Ile Gly Thr Leu Cys Pro Tyr Asp Ala Val Met 
    370                 375                 380                 
Lys Arg Leu Asn Asp Ala Val Asp Arg Thr Ala Leu Leu Pro Val His 
385                 390                 395                 400 
Tyr Thr Pro His His His His His His 
                405                 

<210> 12
<211> 409
<212> PRT
<213> Artificial Sequence


<220> 
<223> Variant of wt sequence (Seq2)

<400> 12
Asp Thr Pro Ser Ser Gly Trp Thr Leu Glu Lys Val Val Glu Val Ser 
1               5                   10                  15      
Arg His Gly Val Arg Pro Pro Thr Glu Ser Asn Val Lys Thr Ile Gln 
            20                  25                  30          
Glu Gly Thr Asp Arg Gln Trp Pro Thr Trp Leu Thr Gln Tyr Gly Glu 
        35                  40                  45              
Leu Thr Gly His Gly Tyr Ala Ala Ala Val Leu Lys Gly His Tyr Glu 
    50                  55                  60                  
Gly Gln Tyr Leu Arg Gln His Gly Leu Leu Cys Gln Ala Cys Pro Ala 
65                  70                  75                  80  
Pro Gly Asp Val Phe Val Trp Ala Ser Pro Leu Gln Arg Thr Arg Glu 
                85                  90                  95      
Thr Ala Met Ala Leu Met Asp Gly Val Phe Pro Gly Cys Gly Val Ala 
            100                 105                 110         
Ile Gln Gly Pro Glu Asp Glu Asp Asn Asp Pro Leu Phe His Ala Glu 
        115                 120                 125             
Thr Ala Gly Val Thr Leu Asp Gln Gln Gln Val Lys Ala Asp Leu Gln 
    130                 135                 140                 
Asn Ala Met Gln Asn Lys Ser Ala Ala Gln Ile Gln Ala Gln Trp Gln 
145                 150                 155                 160 
Pro Ala Ile Asp Arg Leu Lys Gln Ala Val Cys Leu Pro Asp Lys Pro 
                165                 170                 175     
Cys Pro Ala Phe Ser Thr Pro Trp Glu Val Lys Glu Asp Asn Asn Arg 
            180                 185                 190         
Ser Ile Ser Leu His Gly Pro Glu Val Leu Ala Ile Ile Ala Glu Thr 
        195                 200                 205             
Ile Gln Met Ser Tyr Ser Asn Asn Asn Pro Leu Ser Glu Val Ala Phe 
    210                 215                 220                 
Gly His Ala Lys Thr Ala Ala Glu Val Ala Ala Leu Met Pro Leu Leu 
225                 230                 235                 240 
Thr Ala Asn Tyr Asp Phe Thr Asn Asp Leu Pro Tyr Val Ala His Arg 
                245                 250                 255     
Gly Ala Ser Val Leu Met Asn Gln Ile Ala Leu Ala Leu Asn Thr Glu 
            260                 265                 270         
His Gln Ala Asp Ala Pro Pro Asp Ala Lys Trp Leu Leu Tyr Val Ala 
        275                 280                 285             
His Asp Thr Asn Ile Ala Lys Leu Arg Thr Met Leu Gly Phe Thr Trp 
    290                 295                 300                 
Gln Met Gly Asp Tyr Pro Arg Gly Asn Ile Pro Pro Ala Gly Ser Leu 
305                 310                 315                 320 
Ile Phe Glu Arg Trp Arg Asn Gln Gln Ser Gly Gln Arg Val Val Arg 
                325                 330                 335     
Ile Tyr Phe Gln Ala Gln Ser Leu Asp Gln Ile Arg Gly Leu Ala Ala 
            340                 345                 350         
Leu Asp Asp Ser His Pro Pro Leu Arg Ser Glu Phe Ser Met Pro Asp 
        355                 360                 365             
Cys Gln Lys Thr Asp Ile Gly Thr Leu Cys Pro Tyr Asp Ala Val Met 
    370                 375                 380                 
Lys Arg Leu Asn Asp Ala Val Asp Arg Thr Ala Leu Leu Pro Val His 
385                 390                 395                 400 
Tyr Thr Pro His His His His His His 
                405                 

<210> 13
<211> 409
<212> PRT
<213> Artificial Sequence


<220> 
<223> Variant of wt sequence (Seq2)

<400> 13
Asp Thr Pro Ser Ser Gly Trp Thr Leu Glu Lys Val Val Glu Val Ser 
1               5                   10                  15      
Arg His Gly Val Arg Pro Pro Thr Glu Ser Asn Val Lys Thr Ile Gln 
            20                  25                  30          
Glu Gly Thr Asp Arg Gln Trp Pro Thr Trp Leu Thr Gln Tyr Gly Glu 
        35                  40                  45              
Leu Thr Gly His Gly Tyr Ala Ala Ala Val Leu Lys Gly His Tyr Glu 
    50                  55                  60                  
Gly Gln Tyr Leu Arg Gln His Gly Leu Leu Cys Gln Ala Cys Pro Ala 
65                  70                  75                  80  
Pro Gly Asp Val Phe Val Trp Ala Ser Pro Leu Gln Arg Thr Arg Glu 
                85                  90                  95      
Thr Ala Met Ala Leu Met Asp Gly Val Phe Pro Gly Cys Gly Val Ala 
            100                 105                 110         
Ile Gln Gly Pro Glu Asp Glu Asp Asn Asp Pro Leu Phe His Ala Glu 
        115                 120                 125             
Thr Ala Gly Val Thr Leu Asp Gln Gln Gln Val Lys Ala Asp Leu Gln 
    130                 135                 140                 
Asn Ala Met Gln Asn Lys Ser Ala Ala Gln Ile Gln Ala Gln Trp Gln 
145                 150                 155                 160 
Pro Ala Ile Asp Arg Leu Lys Gln Ala Val Cys Leu Pro Asp Lys Pro 
                165                 170                 175     
Cys Pro Ala Phe Ser Thr Pro Trp Glu Val Lys Glu Asp Asn Asn Gly 
            180                 185                 190         
Ser Ile Ser Leu His Gly Pro Glu Val Leu Ala Ile Ile Ala Glu Thr 
        195                 200                 205             
Ile Arg Met Ser Tyr Ser Asn Asn Asn Pro Leu Ser Glu Val Ala Phe 
    210                 215                 220                 
Gly His Ala Lys Thr Ala Ala Glu Val Ala Ala Leu Met Pro Leu Leu 
225                 230                 235                 240 
Thr Ala Asn Tyr Asp Phe Thr Asn Asp Leu Pro Tyr Val Ala Arg Arg 
                245                 250                 255     
Gly Ala Ser Val Leu Met Asn Gln Ile Ala Leu Ala Leu Asn Thr Glu 
            260                 265                 270         
His Gln Ala Asp Ala Pro Pro Asp Ala Lys Trp Leu Leu Tyr Val Ala 
        275                 280                 285             
His Asp Thr Asn Ile Ala Lys Leu Arg Thr Met Leu Gly Phe Thr Trp 
    290                 295                 300                 
Gln Met Gly Asp Tyr Pro Arg Gly Asn Ile Pro Pro Ala Gly Ser Leu 
305                 310                 315                 320 
Ile Phe Glu Arg Trp Arg Asn Gln Gln Ser Gly Gln Arg Val Val Arg 
                325                 330                 335     
Ile Tyr Phe Gln Ala Gln Ser Leu Asp Gln Ile Arg Gly Leu Ala Ala 
            340                 345                 350         
Leu Asp Asp Ser His Pro Pro Leu Arg Ser Glu Phe Ser Met Pro Asp 
        355                 360                 365             
Cys Gln Lys Thr Asp Ile Gly Thr Leu Cys Pro Tyr Asp Ala Val Met 
    370                 375                 380                 
Lys Arg Leu Asn Asp Ala Val Asp Arg Thr Ala Leu Leu Pro Val His 
385                 390                 395                 400 
Tyr Thr Pro His His His His His His 
                405                 

<210> 14
<211> 409
<212> PRT
<213> Artificial Sequence


<220> 
<223> Variant of wt sequence (Seq2)

<400> 14
Asp Thr Pro Ser Ser Gly Trp Thr Leu Glu Lys Val Val Glu Val Ser 
1               5                   10                  15      
Arg His Gly Val Arg Pro Pro Thr Glu Ser Asn Val Lys Thr Ile Gln 
            20                  25                  30          
Glu Gly Thr Asp Arg Gln Trp Pro Thr Trp Leu Thr Gln Tyr Gly Glu 
        35                  40                  45              
Leu Thr Gly His Gly Tyr Ala Ala Ala Val Leu Lys Gly His Tyr Glu 
    50                  55                  60                  
Gly Gln Tyr Leu Arg Gln His Gly Leu Leu Cys Gln Ala Cys Pro Ala 
65                  70                  75                  80  
Pro Gly Asp Val Phe Val Trp Ala Ser Pro Leu Gln Arg Thr Arg Glu 
                85                  90                  95      
Thr Ala Met Ala Leu Met Asp Gly Val Phe Pro Gly Cys Gly Val Ala 
            100                 105                 110         
Ile Gln Gly Pro Glu Asp Glu Asp Asn Asp Pro Leu Phe His Ala Glu 
        115                 120                 125             
Thr Ala Gly Val Thr Leu Asp Gln Gln Gln Val Lys Ala Asp Leu Gln 
    130                 135                 140                 
Asn Ala Met Gln Asn Lys Ser Ala Ala Gln Ile Gln Ala Gln Trp Gln 
145                 150                 155                 160 
Pro Ala Ile Asp Arg Leu Lys Gln Ala Val Cys Leu Pro Asp Lys Pro 
                165                 170                 175     
Cys Pro Ala Phe Ser Thr Pro Trp Glu Val Lys Glu Asp Asn Asn Gly 
            180                 185                 190         
Ser Ile Ser Leu His Gly Pro Glu Val Leu Ala Ile Ile Ala Glu Thr 
        195                 200                 205             
Ile Gln Met Ser Tyr Ser Asn Asn Asn Pro Leu Ser Glu Val Ala Phe 
    210                 215                 220                 
Gly His Ala Lys Thr Thr Ala Glu Val Ala Ala Leu Met Pro Leu Leu 
225                 230                 235                 240 
Thr Ala Asn Tyr Asp Phe Thr Lys Asp Leu Pro Tyr Val Ala Arg Arg 
                245                 250                 255     
Gly Ala Ser Val Leu Met Asn Gln Ile Ala Leu Ala Leu Asn Thr Glu 
            260                 265                 270         
His Gln Ala Asp Ala Pro Pro Asp Ala Lys Trp Leu Leu Tyr Val Ala 
        275                 280                 285             
His Asp Thr Asn Ile Ala Lys Leu Arg Thr Met Leu Gly Phe Thr Trp 
    290                 295                 300                 
Gln Met Gly Asp Tyr Pro Arg Gly Asn Ile Pro Pro Ala Gly Ser Leu 
305                 310                 315                 320 
Ile Phe Glu Arg Trp Arg Asn Gln Gln Ser Gly Gln Arg Val Val Arg 
                325                 330                 335     
Ile Tyr Phe Gln Ala Gln Ser Leu Asp Gln Ile Arg Gly Leu Ala Ala 
            340                 345                 350         
Leu Asp Asp Ser His Pro Pro Leu Arg Ser Glu Phe Ser Met Pro Asp 
        355                 360                 365             
Cys Gln Lys Thr Asp Ile Gly Thr Leu Cys Pro Tyr Asp Ala Val Met 
    370                 375                 380                 
Lys Arg Leu Asn Asp Ala Val Asp Arg Thr Thr Leu Leu Pro Val His 
385                 390                 395                 400 
Tyr Thr Pro His His His His His His 
                405                 

<210> 15
<211> 409
<212> PRT
<213> Artificial Sequence


<220> 
<223> Variant of wt sequence (Seq2)

<400> 15
Asp Thr Pro Ser Ser Gly Trp Thr Leu Glu Lys Val Val Glu Val Ser 
1               5                   10                  15      
Arg His Gly Val Arg Pro Pro Thr Glu Ser Asn Val Lys Thr Ile Gln 
            20                  25                  30          
Glu Gly Thr Asp Arg Gln Trp Pro Thr Trp Leu Thr Gln Tyr Gly Glu 
        35                  40                  45              
Leu Thr Gly His Gly Tyr Ala Ala Ala Val Leu Lys Gly His Tyr Glu 
    50                  55                  60                  
Gly Gln Tyr Leu Arg Gln His Gly Leu Leu Cys Gln Ala Cys Pro Ala 
65                  70                  75                  80  
Pro Gly Asp Val Phe Val Trp Ala Ser Pro Leu Gln Arg Thr Arg Glu 
                85                  90                  95      
Thr Ala Met Ala Leu Met Asp Gly Val Phe Pro Gly Cys Gly Val Ala 
            100                 105                 110         
Ile Gln Gly Pro Glu Asp Glu Asp Asn Asp Pro Leu Phe His Ala Glu 
        115                 120                 125             
Thr Ala Gly Val Thr Leu Asp Gln Gln Gln Val Lys Ala Asp Leu Gln 
    130                 135                 140                 
Asn Ala Met Gln Asn Lys Ser Ala Ala Gln Ile Gln Ala Gln Trp Gln 
145                 150                 155                 160 
Pro Ala Ile Asp Arg Leu Lys Gln Ala Val Cys Leu Pro Asp Lys Pro 
                165                 170                 175     
Cys Pro Ala Phe Ser Thr Pro Trp Glu Val Lys Glu Asp Asn Asn Gly 
            180                 185                 190         
Ser Ile Ser Leu His Gly Pro Glu Val Leu Ala Ile Ile Ala Glu Thr 
        195                 200                 205             
Ile Arg Met Ser Tyr Ser Asn Asn Asn Pro Leu Ser Glu Val Ala Phe 
    210                 215                 220                 
Gly His Ala Lys Thr Ala Ala Glu Val Ala Ala Leu Met Pro Leu Leu 
225                 230                 235                 240 
Thr Ala Asn Tyr Asp Phe Thr Asn Asp Leu Pro Tyr Val Ala Arg Arg 
                245                 250                 255     
Ser Ala Ser Val Leu Met Asn Gln Ile Ala Leu Ala Leu Asn Thr Glu 
            260                 265                 270         
His Gln Ala Gly Ala Pro Pro Asp Ala Lys Trp Leu Leu Tyr Val Ala 
        275                 280                 285             
His Asp Thr Asn Ile Ala Lys Leu Arg Thr Met Leu Gly Phe Thr Trp 
    290                 295                 300                 
Gln Met Gly Asp Tyr Pro Arg Gly Asn Ile Pro Pro Ala Gly Ser Leu 
305                 310                 315                 320 
Ile Phe Glu Arg Trp Arg Asn Gln Gln Ser Gly Gln Arg Val Val Arg 
                325                 330                 335     
Ile Tyr Phe Gln Ala Gln Ser Leu Asp Gln Ile Arg Gly Leu Ala Ala 
            340                 345                 350         
Leu Asp Asp Ser His Pro Pro Leu Arg Ser Glu Phe Ser Met Pro Asp 
        355                 360                 365             
Cys Gln Lys Thr Asp Ile Gly Thr Leu Cys Pro Tyr Asp Ala Val Met 
    370                 375                 380                 
Lys Arg Leu Asn Asp Ala Val Asp Arg Thr Ala Leu Leu Pro Val His 
385                 390                 395                 400 
Tyr Thr Pro His His His His His His 
                405                 

<210> 16
<211> 409
<212> PRT
<213> Artificial Sequence


<220> 
<223> Variant of wt sequence (Seq2)

<400> 16
Asp Thr Pro Ser Ser Gly Trp Thr Leu Glu Lys Val Val Glu Val Ser 
1               5                   10                  15      
Arg His Gly Val Arg Pro Pro Thr Glu Ser Asn Val Lys Thr Ile Gln 
            20                  25                  30          
Glu Gly Thr Asp Arg Gln Trp Pro Thr Trp Leu Thr Gln Tyr Gly Glu 
        35                  40                  45              
Leu Thr Gly His Gly Tyr Ala Ala Ala Val Leu Lys Gly His Tyr Glu 
    50                  55                  60                  
Gly Gln Tyr Leu Arg Gln His Gly Leu Leu Cys Gln Ala Cys Pro Ala 
65                  70                  75                  80  
Pro Gly Asp Val Phe Val Trp Ala Ser Pro Leu Gln Arg Thr Arg Glu 
                85                  90                  95      
Thr Ala Met Ala Leu Met Asp Gly Val Phe Pro Gly Cys Gly Val Ala 
            100                 105                 110         
Ile Gln Gly Pro Glu Asp Glu Asp Asn Asp Pro Leu Phe His Ala Glu 
        115                 120                 125             
Thr Ala Gly Val Thr Leu Asp Gln Gln Gln Val Lys Ala Asp Leu Gln 
    130                 135                 140                 
Asn Ala Met Gln Asn Lys Ser Ala Ala Gln Ile Gln Ala Gln Trp Gln 
145                 150                 155                 160 
Pro Ala Ile Asp Arg Leu Lys Gln Ala Val Cys Leu Pro Asp Lys Pro 
                165                 170                 175     
Cys Pro Ala Phe Ser Thr Pro Trp Glu Val Lys Glu Asp Asn Asn Gly 
            180                 185                 190         
His Ile Ser Leu His Gly Pro Glu Val Leu Ala Ile Ile Ala Glu Thr 
        195                 200                 205             
Ile Gln Met Ser Tyr Ser Asn Asn Asn Pro Leu Ser Glu Val Ala Phe 
    210                 215                 220                 
Gly His Ala Lys Thr Ala Ala Glu Val Ala Ala Leu Met Pro Leu Leu 
225                 230                 235                 240 
Thr Ala Asn Tyr Asp Phe Thr Asn Asp Leu Pro Tyr Val Ala Arg Arg 
                245                 250                 255     
Gly Ala Ser Val Leu Met Asn Gln Ile Ala Leu Ala Leu Asn Thr Glu 
            260                 265                 270         
His Gln Ala Asp Ala Pro Pro Asp Ala Lys Trp Leu Leu Tyr Val Ala 
        275                 280                 285             
His Asp Thr Asn Ile Ala Lys Leu Arg Thr Met Leu Gly Phe Thr Trp 
    290                 295                 300                 
Gln Met Gly Asp Tyr Pro Arg Gly Asn Ile Pro Pro Ala Gly Ser Leu 
305                 310                 315                 320 
Ile Phe Glu Arg Trp Arg Asn Gln Gln Ser Gly Gln Arg Val Val Arg 
                325                 330                 335     
Ile Tyr Phe Gln Ala Gln Ser Leu Asp Gln Ile Arg Gly Leu Ala Ala 
            340                 345                 350         
Leu Asp Asp Ser His Pro Pro Leu Arg Ser Glu Phe Ser Met Pro Asp 
        355                 360                 365             
Cys Gln Lys Thr Asp Ile Gly Thr Leu Cys Pro Tyr Asp Ala Val Met 
    370                 375                 380                 
Lys Arg Leu Asn Asp Ala Val Asp Arg Thr Ala Leu Leu Pro Val His 
385                 390                 395                 400 
Tyr Thr Pro His His His His His His 
                405                 

<210> 17
<211> 409
<212> PRT
<213> Artificial Sequence


<220> 
<223> Variant of wt sequence (Seq2)

<400> 17
Asp Thr Pro Ser Ser Gly Trp Thr Leu Glu Lys Val Val Glu Val Ser 
1               5                   10                  15      
Arg His Gly Val Arg Pro Pro Thr Glu Ser Asn Val Lys Thr Ile Gln 
            20                  25                  30          
Glu Gly Thr Asp Arg Gln Trp Pro Thr Trp Leu Thr Arg Tyr Gly Glu 
        35                  40                  45              
Leu Thr Gly His Gly Tyr Ala Ala Ala Val Leu Lys Gly His Tyr Glu 
    50                  55                  60                  
Gly Gln Tyr Leu Arg Gln His Gly Leu Leu Cys Gln Ala Cys Pro Ala 
65                  70                  75                  80  
Pro Gly Asp Val Phe Val Trp Ala Ser Pro Leu Gln Arg Thr Arg Glu 
                85                  90                  95      
Thr Ala Met Ala Leu Met Asp Gly Val Phe Pro Gly Cys Gly Val Ala 
            100                 105                 110         
Ile Gln Gly Pro Glu Asp Glu Asp Asn Asp Pro Leu Phe His Ala Glu 
        115                 120                 125             
Thr Ala Gly Val Thr Leu Asp Gln Gln Gln Val Lys Ala Asp Leu Gln 
    130                 135                 140                 
Asn Ala Met Gln Asn Lys Ser Ala Ala Gln Ile Gln Ala Gln Trp Gln 
145                 150                 155                 160 
Pro Ala Ile Asp Arg Leu Lys Gln Ala Val Cys Leu Pro Asp Lys Pro 
                165                 170                 175     
Cys Pro Ala Phe Ser Thr Pro Trp Glu Val Lys Glu Asp Asn Asn Gly 
            180                 185                 190         
Ser Ile Ser Leu His Gly Pro Glu Val Leu Ala Ile Ile Ala Glu Thr 
        195                 200                 205             
Ile Gln Met Ser Tyr Ser Asn Asn Asn Pro Leu Ser Glu Val Ala Phe 
    210                 215                 220                 
Gly His Ala Lys Thr Ala Ala Glu Val Ala Ala Leu Met Pro Leu Leu 
225                 230                 235                 240 
Thr Ala Asn Tyr Asp Phe Thr Asn Asp Leu Pro Tyr Val Ala Arg Arg 
                245                 250                 255     
Gly Ala Ser Val Leu Met Asn Gln Ile Ala Leu Ala Leu Asn Thr Glu 
            260                 265                 270         
His Gln Pro Asp Ala Pro Pro Asp Ala Lys Trp Leu Leu Tyr Val Ala 
        275                 280                 285             
His Asp Thr Asn Ile Ala Lys Leu Arg Thr Met Leu Gly Phe Thr Trp 
    290                 295                 300                 
Gln Met Gly Asp Tyr Pro Arg Gly Asn Ile Pro Pro Ala Gly Ser Leu 
305                 310                 315                 320 
Ile Phe Glu Arg Trp Arg Asn Gln Gln Ser Gly Gln Arg Val Val Arg 
                325                 330                 335     
Ile Tyr Phe Gln Ala Gln Ser Leu Asp Gln Ile Arg Gly Leu Ala Ala 
            340                 345                 350         
Leu Asp Asp Ser His Pro Pro Leu Arg Ser Glu Phe Ser Met Pro Asp 
        355                 360                 365             
Cys Gln Lys Thr Asp Ile Gly Thr Leu Cys Pro Tyr Asp Ala Val Met 
    370                 375                 380                 
Lys Arg Leu Asn Asp Ala Val Asp Arg Thr Ala Leu Leu Pro Val His 
385                 390                 395                 400 
Tyr Thr Pro His His His His His His 
                405                 

<210> 18
<211> 409
<212> PRT
<213> Artificial Sequence


<220> 
<223> Variant of wt sequence (Seq2)

<400> 18
Asp Thr Pro Ser Ser Gly Trp Thr Leu Glu Lys Val Val Glu Val Ser 
1               5                   10                  15      
Arg His Gly Val Arg Pro Pro Thr Glu Ser Asn Val Lys Thr Ile Gln 
            20                  25                  30          
Glu Gly Thr Asp Arg Gln Trp Pro Thr Trp Leu Thr Asn Tyr Gly Glu 
        35                  40                  45              
Leu Thr Gly His Gly Tyr Ala Ala Ala Val Leu Lys Gly His Tyr Glu 
    50                  55                  60                  
Gly Gln Tyr Leu Arg Gln His Gly Leu Leu Cys Gln Ala Cys Pro Ala 
65                  70                  75                  80  
Pro Gly Asp Val Phe Val Trp Ala Ser Pro Leu Gln Arg Thr Arg Glu 
                85                  90                  95      
Thr Ala Met Ala Leu Met Asp Gly Val Phe Pro Gly Cys Gly Val Ala 
            100                 105                 110         
Ile Gln Gly Pro Glu Asp Glu Asp Asn Asp Pro Leu Phe His Ala Glu 
        115                 120                 125             
Thr Ala Gly Val Thr Leu Asp Gln Gln Gln Val Lys Ala Asp Leu Gln 
    130                 135                 140                 
Asn Ala Met Gln Asn Lys Ser Ala Ala Gln Ile Gln Ala Gln Trp Gln 
145                 150                 155                 160 
Pro Ala Ile Asp Arg Leu Lys Gln Ala Val Cys Leu Pro Asp Lys Pro 
                165                 170                 175     
Cys Pro Ala Phe Ser Thr Pro Trp Glu Val Lys Glu Asp Asn Asn Gly 
            180                 185                 190         
Ser Ile Ser Leu His Gly Pro Glu Val Leu Ala Ile Ile Ala Glu Thr 
        195                 200                 205             
Ile Gln Met Ser Tyr Ser Asn Asn Asn Pro Leu Ser Glu Val Ala Phe 
    210                 215                 220                 
Gly His Ala Lys Thr Ala Ala Glu Val Ala Ala Leu Met Pro Leu Leu 
225                 230                 235                 240 
Thr Ala Asn Tyr Asp Phe Thr Asn Asp Leu Pro Tyr Val Ala Arg Arg 
                245                 250                 255     
Gly Ala Ser Val Leu Met Asn Gln Ile Ala Leu Ala Leu Asn Thr Glu 
            260                 265                 270         
His Gln Ala Asp Ala Pro Pro Asp Ala Lys Trp Leu Leu Tyr Val Ala 
        275                 280                 285             
His Asp Thr Asn Ile Ala Lys Leu Arg Thr Met Leu Gly Phe Thr Trp 
    290                 295                 300                 
Gln Met Gly Asp Tyr Pro Arg Gly Asn Ile Pro Pro Ala Gly Ser Leu 
305                 310                 315                 320 
Ile Phe Glu Arg Trp Arg Asn Gln Gln Ser Gly Gln Arg Val Val Arg 
                325                 330                 335     
Ile Tyr Phe Gln Ala Gln Ser Leu Asp Gln Ile Arg Gly Leu Ala Ala 
            340                 345                 350         
Leu Asp Asp Ser His Pro Pro Leu Arg Ser Glu Phe Ser Met Pro Asp 
        355                 360                 365             
Cys Gln Lys Thr Asp Ile Gly Thr Leu Cys Pro Tyr Asp Ala Val Met 
    370                 375                 380                 
Lys Arg Leu Asn Asp Ala Val Asp Arg Thr Ala Leu Leu Pro Val His 
385                 390                 395                 400 
Tyr Thr Pro His His His His His His 
                405                 

<210> 19
<211> 409
<212> PRT
<213> Artificial Sequence


<220> 
<223> Variant of wt sequence (Seq2)

<400> 19
Asp Thr Pro Ser Ser Gly Trp Thr Leu Glu Lys Val Val Glu Val Ser 
1               5                   10                  15      
Arg His Gly Val Arg Pro Pro Thr Glu Ser Asn Val Lys Thr Ile Gln 
            20                  25                  30          
Glu Gly Thr Asp Arg Gln Trp Pro Thr Trp Leu Thr Gln Tyr Gly Glu 
        35                  40                  45              
Leu Thr Gly His Gly Tyr Ala Ala Ala Glu Leu Lys Gly His Tyr Glu 
    50                  55                  60                  
Gly Gln Tyr Leu Arg Gln His Gly Leu Leu Cys Gln Ala Cys Pro Ala 
65                  70                  75                  80  
Pro Gly Asp Val Phe Val Trp Ala Ser Pro Leu Gln Arg Thr Arg Glu 
                85                  90                  95      
Thr Ala Met Ala Leu Met Asp Gly Val Phe Pro Gly Cys Gly Val Ala 
            100                 105                 110         
Ile Gln Gly Pro Glu Asp Glu Asp Asn Asp Pro Leu Phe His Ala Glu 
        115                 120                 125             
Thr Ala Gly Val Thr Leu Asp Gln Gln Gln Val Lys Ala Asp Leu Gln 
    130                 135                 140                 
Asn Ala Met Gln Asn Lys Ser Ala Ala Gln Ile Gln Ala Gln Trp Gln 
145                 150                 155                 160 
Pro Ala Ile Asp Arg Leu Lys Gln Ala Val Cys Leu Pro Asp Lys Pro 
                165                 170                 175     
Cys Pro Ala Phe Ser Thr Pro Trp Glu Val Lys Glu Asp Asn Asn Gly 
            180                 185                 190         
Ser Ile Arg Leu His Gly Pro Glu Val Leu Ala Ile Ile Ala Glu Thr 
        195                 200                 205             
Ile Gln Met Ser Tyr Ser Asn Asn Asn Pro Leu Ser Glu Val Ala Phe 
    210                 215                 220                 
Gly His Ala Lys Thr Ala Ala Glu Val Ala Ala Leu Met Pro Leu Leu 
225                 230                 235                 240 
Thr Ala Asn Tyr Asp Phe Thr Asn Asp Leu Pro Tyr Val Ala Arg Arg 
                245                 250                 255     
Gly Ala Ser Val Leu Met Asn Gln Ile Ala Leu Ala Leu Asn Thr Glu 
            260                 265                 270         
His Gln Ala Asp Ala Pro Pro Asp Ala Lys Trp Leu Leu Tyr Val Ala 
        275                 280                 285             
His Asp Thr Asn Ile Ala Lys Leu Arg Thr Met Leu Gly Phe Thr Trp 
    290                 295                 300                 
Gln Met Gly Asp Tyr Pro Arg Gly Asn Ile Pro Pro Ala Gly Ser Leu 
305                 310                 315                 320 
Ile Phe Glu Arg Trp Arg Asn Gln Gln Ser Gly Gln Arg Val Val Arg 
                325                 330                 335     
Ile Tyr Phe Gln Ala Gln Ser Leu Asp Gln Ile Arg Gly Leu Ala Ala 
            340                 345                 350         
Leu Asp Asp Ser His Pro Pro Leu Arg Ser Glu Phe Ser Met Pro Asp 
        355                 360                 365             
Cys Gln Lys Thr Asp Ile Gly Thr Leu Cys Pro Tyr Asp Ala Val Met 
    370                 375                 380                 
Lys Arg Leu Asn Asp Ala Val Asp Arg Thr Ala Leu Leu Pro Val His 
385                 390                 395                 400 
Tyr Thr Pro His His His His His His 
                405                 

<210> 20
<211> 409
<212> PRT
<213> Artificial Sequence


<220> 
<223> Variant of wt sequence (Seq2)

<400> 20
Asp Thr Pro Ser Ser Gly Trp Thr Leu Glu Lys Val Val Glu Val Ser 
1               5                   10                  15      
Arg His Gly Val Arg Pro Pro Thr Glu Ser Asn Val Lys Thr Ile Gln 
            20                  25                  30          
Glu Gly Thr Asp Arg Gln Trp Pro Thr Trp Leu Thr Gln Tyr Gly Glu 
        35                  40                  45              
Leu Thr Gly His Gly Tyr Ala Ala Ala Val Leu Lys Gly His Tyr Glu 
    50                  55                  60                  
Gly Gln Tyr Leu Arg Gln His Gly Leu Leu Cys Gln Ala Cys Pro Ala 
65                  70                  75                  80  
Pro Gly Asp Val Phe Val Trp Ala Ser Pro Leu Gln Arg Thr Arg Glu 
                85                  90                  95      
Thr Ala Met Ala Leu Met Asp Gly Val Phe Pro Gly Cys Gly Val Ala 
            100                 105                 110         
Ile Gln Gly Pro Glu Asp Glu Asp Asn Asp Pro Leu Phe His Ala Glu 
        115                 120                 125             
Thr Ala Gly Val Thr Leu Asp Gln Gln Gln Val Lys Ala Asp Leu Gln 
    130                 135                 140                 
Asn Ala Met Gln Asn Lys Ser Ala Ala Gln Ile Gln Ala Gln Trp Gln 
145                 150                 155                 160 
Pro Ala Ile Asp Arg Leu Lys Gln Ala Val Cys Leu Pro Asp Lys Pro 
                165                 170                 175     
Cys Pro Ala Phe Ser Thr Pro Trp Glu Val Lys Glu Asp Asn Asn Gly 
            180                 185                 190         
Ser Ile Ser Leu His Gly Pro Glu Val Leu Ala Ile Ile Ala Glu Thr 
        195                 200                 205             
Ile Gln Met Ser Tyr Ser Asn Asn Asn Pro Leu Ser Glu Val Ala Phe 
    210                 215                 220                 
Gly His Ala Lys Thr Ala Ala Glu Val Ala Ala Leu Met Pro Leu Leu 
225                 230                 235                 240 
Thr Ala Asn Tyr Asp Phe Thr Lys Asp Leu Pro Tyr Val Ala Arg Arg 
                245                 250                 255     
Gly Ala Ser Val Leu Met Asn Gln Ile Ala Leu Ala Leu Asn Thr Glu 
            260                 265                 270         
His Gln Ala Asp Ala Pro Pro Asp Ala Lys Trp Leu Leu Tyr Val Ala 
        275                 280                 285             
His Asp Thr Asn Ile Ala Lys Leu Arg Thr Met Leu Gly Phe Thr Trp 
    290                 295                 300                 
Gln Met Gly Asp Tyr Pro Arg Gly Asn Ile Pro Pro Ala Gly Ser Leu 
305                 310                 315                 320 
Ile Phe Glu Arg Trp Arg Asn Gln Gln Ser Gly Gln Arg Val Val Arg 
                325                 330                 335     
Ile Tyr Phe Gln Ala Gln Ser Leu Asp Gln Ile Arg Gly Leu Ala Ala 
            340                 345                 350         
Leu Asp Asp Ser His Pro Pro Leu Arg Ser Glu Phe Ser Met Pro Asp 
        355                 360                 365             
Cys Gln Lys Thr Asp Ile Gly Thr Leu Cys Pro Tyr Asp Ala Val Met 
    370                 375                 380                 
Lys Arg Leu Asn Asp Ala Val Asp Arg Thr Ala Leu Leu Pro Val His 
385                 390                 395                 400 
Tyr Thr Pro His His His His His His 
                405                 

<210> 21
<211> 409
<212> PRT
<213> Artificial Sequence


<220> 
<223> Variant of wt sequence (Seq2)

<400> 21
Asp Thr Pro Ser Ser Gly Trp Thr Leu Glu Lys Val Val Glu Val Ser 
1               5                   10                  15      
Arg His Gly Val Arg Pro Pro Thr Glu Ser Asn Val Lys Ser Ile Gln 
            20                  25                  30          
Glu Gly Thr Asp Arg Gln Trp Pro Thr Trp Leu Thr Gln Tyr Gly Glu 
        35                  40                  45              
Leu Thr Gly His Gly Tyr Ala Ala Ala Val Leu Lys Gly His Tyr Glu 
    50                  55                  60                  
Gly Gln Tyr Leu Arg Gln His Gly Leu Leu Cys Gln Ala Cys Pro Ala 
65                  70                  75                  80  
Pro Gly Asp Val Phe Val Trp Ala Ser Pro Leu Gln Arg Thr Arg Glu 
                85                  90                  95      
Thr Ala Met Ala Leu Met Asp Gly Val Phe Pro Gly Cys Gly Val Ala 
            100                 105                 110         
Ile Gln Gly Pro Glu Asp Glu Asp Asn Asp Pro Leu Phe His Ala Glu 
        115                 120                 125             
Thr Ala Gly Val Thr Leu Asp Gln Gln Gln Val Lys Ala Asp Leu Gln 
    130                 135                 140                 
Asn Ala Met Gln Asn Lys Ser Ala Ala Gln Ile Gln Ala Gln Trp Gln 
145                 150                 155                 160 
Pro Ala Ile Asp Arg Leu Lys Gln Ala Val Cys Leu Pro Asp Lys Pro 
                165                 170                 175     
Cys Pro Ala Phe Ser Thr Pro Trp Glu Val Lys Glu Asp Asn Asn Gly 
            180                 185                 190         
Ser Ile Ser Leu His Gly Pro Glu Val Leu Ala Ile Ile Ala Glu Thr 
        195                 200                 205             
Ile Gln Met Ser Tyr Ser Asn Asn Asn Pro Leu Ser Glu Val Ala Phe 
    210                 215                 220                 
Gly His Ala Lys Thr Ala Ala Glu Val Ala Ala Leu Met Pro Leu Leu 
225                 230                 235                 240 
Thr Ala Asn Tyr Asp Phe Thr Lys Asp Leu Pro Tyr Val Ala Arg Arg 
                245                 250                 255     
Gly Ala Ser Val Leu Met Asn Gln Ile Ala Leu Ala Leu Asn Thr Glu 
            260                 265                 270         
His Gln Ala Asp Ala Pro Pro Asp Ala Lys Trp Leu Leu Tyr Val Ala 
        275                 280                 285             
His Asp Thr Asn Ile Ala Lys Leu Arg Thr Met Leu Gly Phe Thr Trp 
    290                 295                 300                 
Gln Met Gly Asp Tyr Pro Arg Gly Asn Ile Pro Pro Ala Gly Ser Leu 
305                 310                 315                 320 
Ile Phe Glu Arg Trp Arg Asn Gln Gln Ser Gly Gln Arg Val Val Arg 
                325                 330                 335     
Ile Tyr Phe Gln Ala Gln Ser Leu Asp Gln Ile Arg Gly Leu Ala Ala 
            340                 345                 350         
Leu Asp Asp Ser His Pro Pro Leu Arg Ser Glu Phe Ser Met Pro Asp 
        355                 360                 365             
Cys Gln Lys Thr Asp Ile Gly Thr Leu Cys Pro Tyr Asp Ala Val Met 
    370                 375                 380                 
Lys Arg Leu Asn Asp Ala Val Asp Arg Thr Ala Leu Leu Pro Val His 
385                 390                 395                 400 
Tyr Thr Pro His His His His His His 
                405                 

<210> 22
<211> 409
<212> PRT
<213> Artificial Sequence


<220> 
<223> Variant of wt sequence (Seq2)

<400> 22
Asp Thr Pro Ser Ser Gly Trp Thr Leu Glu Lys Val Val Glu Val Ser 
1               5                   10                  15      
Arg His Gly Val Arg Pro Pro Thr Glu Ser Asn Val Lys Thr Ile Gln 
            20                  25                  30          
Glu Gly Thr Asp Arg Gln Trp Pro Thr Trp Leu Thr Gln Tyr Gly Glu 
        35                  40                  45              
Leu Thr Gly His Gly Tyr Ala Ala Ala Val Leu Lys Gly His Tyr Glu 
    50                  55                  60                  
Gly Gln Tyr Leu Arg Gln His Gly Leu Leu Cys Gln Ala Cys Pro Ala 
65                  70                  75                  80  
Pro Gly Asp Val Phe Val Trp Ala Ser Pro Leu Gln Arg Thr Arg Glu 
                85                  90                  95      
Thr Ala Met Ala Leu Met Asp Gly Val Phe Pro Gly Cys Gly Val Ala 
            100                 105                 110         
Ile Gln Gly Pro Glu Asp Glu Asp Asn Asp Pro Leu Phe His Ala Glu 
        115                 120                 125             
Thr Ala Gly Val Thr Leu Asp Gln Gln Gln Val Lys Ala Asp Leu Gln 
    130                 135                 140                 
Asn Ala Met Gln Asn Lys Ser Ala Ala Gln Ile Gln Ala Gln Trp Gln 
145                 150                 155                 160 
Pro Ala Ile Asp Arg Leu Lys Gln Ala Val Cys Leu Pro Asp Lys Pro 
                165                 170                 175     
Cys Pro Ala Phe Ser Thr Pro Trp Glu Val Lys Glu Asp Asn Asn Gly 
            180                 185                 190         
Ser Ile Ser Leu His Gly Pro Glu Val Leu Ala Ile Ile Ala Glu Thr 
        195                 200                 205             
Ile Arg Met Ser Tyr Ser Asn Asn Asn Pro Leu Ser Glu Val Ala Phe 
    210                 215                 220                 
Gly His Ala Lys Thr Ala Ala Glu Val Ala Ala Leu Met Pro Leu Leu 
225                 230                 235                 240 
Thr Ala Asn Tyr Asp Phe Thr Asn Asp Leu Pro Tyr Val Ala Arg Arg 
                245                 250                 255     
Gly Ala Ser Val Leu Met Asn Gln Ile Ala Leu Ala Leu Asn Thr Glu 
            260                 265                 270         
His Gln Ala Asp Ala Pro Pro Asp Ala Lys Trp Leu Leu Tyr Val Ala 
        275                 280                 285             
His Asp Thr Asn Ile Ala Lys Leu Arg Thr Met Leu Gly Phe Thr Trp 
    290                 295                 300                 
Gln Met Gly Asp Tyr Pro Arg Gly Asn Ile Pro Pro Ala Gly Ser Leu 
305                 310                 315                 320 
Ile Phe Glu Arg Trp Arg Asn Gln Gln Ser Gly Gln Arg Val Val Arg 
                325                 330                 335     
Ile Tyr Phe Gln Ala Gln Ser Leu Asp Gln Ile Arg Gly Leu Ala Ser 
            340                 345                 350         
Leu Asp Asp Ser His Pro Pro Leu Arg Ser Glu Phe Ser Met Pro Asp 
        355                 360                 365             
Cys Gln Lys Thr Asp Ile Gly Thr Leu Cys Pro Tyr Asp Ala Val Met 
    370                 375                 380                 
Lys Arg Leu Asn Asp Ala Val Asp Arg Thr Ala Leu Leu Pro Val His 
385                 390                 395                 400 
Tyr Thr Pro His His His His His His 
                405                 

<210> 23
<211> 409
<212> PRT
<213> Artificial Sequence


<220> 
<223> Variant of wt sequence (Seq2)

<400> 23
Asp Thr Pro Ser Ser Gly Trp Thr Leu Glu Lys Val Val Glu Val Ser 
1               5                   10                  15      
Arg His Gly Val Arg Pro Pro Thr Glu Lys Asn Val Lys Thr Ile Gln 
            20                  25                  30          
Glu Gly Thr Asp Arg Gln Trp Pro Thr Trp Leu Thr Gln Tyr Gly Glu 
        35                  40                  45              
Leu Thr Gly His Gly Tyr Ala Ala Ala Val Leu Lys Gly His Tyr Glu 
    50                  55                  60                  
Gly Gln Tyr Leu Arg Gln His Gly Leu Leu Cys Gln Ala Cys Pro Ala 
65                  70                  75                  80  
Pro Gly Asp Val Phe Val Trp Ala Ser Pro Leu Gln Arg Thr Arg Glu 
                85                  90                  95      
Thr Ala Met Ala Leu Met Asp Gly Val Phe Pro Gly Cys Gly Val Ala 
            100                 105                 110         
Ile Gln Gly Pro Glu Asp Glu Asp Asn Asp Pro Leu Phe His Ala Glu 
        115                 120                 125             
Thr Ala Gly Val Thr Leu Asp Gln Gln Gln Val Lys Ala Asp Leu Gln 
    130                 135                 140                 
Asn Ala Met Gln Asn Lys Ser Ala Ala Gln Ile Gln Ala Gln Trp Gln 
145                 150                 155                 160 
Pro Ala Ile Asp Arg Leu Lys Gln Ala Val Cys Leu Pro Asp Lys Pro 
                165                 170                 175     
Cys Pro Ala Phe Ser Thr Pro Trp Glu Val Lys Glu Asp Asn Asn Gly 
            180                 185                 190         
Ser Ile Ser Leu His Gly Pro Glu Val Leu Ala Ile Ile Ala Glu Thr 
        195                 200                 205             
Ile Arg Glu Ser Tyr Ser Asn Asn Asn Pro Leu Ser Glu Val Ala Phe 
    210                 215                 220                 
Gly His Ala Lys Thr Ala Ala Glu Val Ala Ala Leu Met Pro Leu Leu 
225                 230                 235                 240 
Thr Ala Asn Tyr Asp Phe Thr Asn Asp Leu Pro Tyr Val Ala Arg Arg 
                245                 250                 255     
Gly Ala Ser Val Leu Met Asn Gln Ile Ala Leu Ala Leu Asn Thr Glu 
            260                 265                 270         
His Gln Ala Asp Ala Pro Pro Asp Ala Lys Trp Leu Leu Tyr Val Ala 
        275                 280                 285             
His Asp Thr Asn Ile Ala Lys Leu Arg Thr Met Leu Gly Phe Thr Trp 
    290                 295                 300                 
Gln Met Gly Asp Tyr Pro Arg Gly Asn Ile Pro Pro Ala Gly Ser Leu 
305                 310                 315                 320 
Ile Phe Glu Arg Trp Arg Asn Gln Gln Ser Gly Gln Arg Val Val Arg 
                325                 330                 335     
Ile Tyr Phe Gln Ala Gln Ser Leu Asp Gln Ile Arg Gly Leu Ala Ala 
            340                 345                 350         
Leu Asp Asp Ser His Pro Pro Leu Arg Ser Glu Phe Ser Met Pro Asp 
        355                 360                 365             
Cys Gln Lys Thr Asp Ile Gly Thr Leu Cys Pro Tyr Asp Ala Val Met 
    370                 375                 380                 
Lys Arg Leu Asn Asp Ala Val Asp Arg Thr Ala Leu Leu Pro Val His 
385                 390                 395                 400 
Tyr Thr Pro His His His His His His 
                405                 

<210> 24
<211> 409
<212> PRT
<213> Artificial Sequence


<220> 
<223> Variant of wt sequence (Seq2)

<400> 24
Asp Thr Pro Ser Ser Gly Trp Thr Leu Glu Lys Val Val Glu Val Ser 
1               5                   10                  15      
Arg His Gly Val Arg Pro Pro Thr Glu Ser Asn Val Lys Thr Ile Gln 
            20                  25                  30          
Glu Gly Thr Asp Arg Gln Trp Pro Thr Trp Leu Thr Gln Tyr Gly Glu 
        35                  40                  45              
Leu Thr Gly His Gly Tyr Ala Ala Ala Val Leu Lys Gly His Tyr Glu 
    50                  55                  60                  
Gly Gln Tyr Leu Arg Gln His Gly Leu Leu Cys Gln Ala Cys Pro Ala 
65                  70                  75                  80  
Pro Gly Asp Val Phe Val Trp Ala Ser Pro Leu Gln Arg Thr Arg Glu 
                85                  90                  95      
Thr Ala Met Ala Leu Met Asp Gly Val Phe Pro Gly Cys Gly Val Ala 
            100                 105                 110         
Ile Gln Gly Pro Glu Asp Glu Lys Asn Asp Pro Leu Phe His Ala Glu 
        115                 120                 125             
Thr Ala Gly Val Thr Leu Asp Gln Gln Gln Val Lys Ala Asp Leu Gln 
    130                 135                 140                 
Asn Ala Met Gln Asn Lys Ser Ala Ala Gln Ile Gln Ala Gln Trp Gln 
145                 150                 155                 160 
Pro Ala Ile Asp Arg Leu Lys Gln Ala Val Cys Leu Pro Asp Lys Pro 
                165                 170                 175     
Cys Pro Ala Phe Ser Thr Pro Trp Glu Val Lys Glu Asp Asn Asn Gly 
            180                 185                 190         
Arg Ile Tyr Leu His Gly Pro Glu Val Leu Ala Asn Ile Ala Glu Thr 
        195                 200                 205             
Ile Gln Met Ser Tyr Ser Asn Asn Asn Pro Leu Ser Glu Val Ala Phe 
    210                 215                 220                 
Gly His Ala Lys Thr Ala Ala Glu Val Ala Ala Leu Met Pro Leu Leu 
225                 230                 235                 240 
Thr Ala Lys Tyr Asp Phe Thr Asn Asp Leu Pro Tyr Val Ala Arg Arg 
                245                 250                 255     
Gly Ala Ser Val Leu Met Asn Gln Ile Ala Leu Ala Leu Asn Thr Glu 
            260                 265                 270         
His Gln Ala Asp Ala Pro Pro Asp Ala Lys Trp Leu Leu Tyr Val Ala 
        275                 280                 285             
His Asp Thr Asn Ile Ala Tyr Leu Arg Thr Met Leu Gly Phe Thr Trp 
    290                 295                 300                 
Gln Met Gly Asp Tyr Pro Arg Gly Asn Ile Pro Pro Ala Gly Ser Leu 
305                 310                 315                 320 
Ile Phe Glu Arg Trp Arg Asn Gln Gln Ser Gly Gln Arg Val Val Arg 
                325                 330                 335     
Ile Tyr Phe Gln Ala Gln Ser Leu Asp Gln Ile Arg Gly Leu Ala Ala 
            340                 345                 350         
Leu Asp Asp Ser His Pro Pro Leu Arg Ser Glu Phe Ser Met Pro Asp 
        355                 360                 365             
Cys Gln Lys Thr Asp Ile Gly Thr Leu Cys Pro Tyr Asp Ala Val Met 
    370                 375                 380                 
Lys Arg Leu Asn Asp Ala Val Asp Arg Thr Ala Leu Leu Pro Val His 
385                 390                 395                 400 
Tyr Thr Pro His His His His His His 
                405                 

<210> 25
<211> 409
<212> PRT
<213> Artificial Sequence


<220> 
<223> Variant of wt sequence (Seq2)

<400> 25
Asp Thr Pro Ser Ser Gly Trp Thr Leu Glu Lys Val Val Glu Val Ser 
1               5                   10                  15      
Arg His Gly Val Arg Pro Pro Thr Glu Ser Asn Val Lys Ala Ile Gln 
            20                  25                  30          
Glu Gly Thr Asp Arg Gln Trp Pro Thr Trp Leu Thr Gln Tyr Gly Glu 
        35                  40                  45              
Leu Thr Gly His Gly Tyr Ala Ala Ala Val Leu Lys Gly His Tyr Glu 
    50                  55                  60                  
Gly Gln Tyr Leu Arg Gln His Gly Leu Leu Cys Gln Ala Cys Pro Ala 
65                  70                  75                  80  
Pro Gly Asp Val Phe Val Trp Ala Ser Pro Leu Gln Arg Thr Arg Glu 
                85                  90                  95      
Thr Ala Met Ala Leu Met Asp Gly Val Phe Pro Gly Cys Gly Val Ala 
            100                 105                 110         
Ile Gln Gly Pro Glu Asp Glu Asp Asn Asp Pro Leu Phe His Ala Glu 
        115                 120                 125             
Thr Ala Gly Val Thr Leu Asp Gln Gln Gln Val Lys Ala Asp Leu Gln 
    130                 135                 140                 
Asn Ala Met Gln Asn Lys Ser Ala Ala Gln Ile Gln Ala Gln Trp Gln 
145                 150                 155                 160 
Pro Ala Ile Asp Arg Leu Lys Gln Ala Val Cys Leu Pro Asp Lys Pro 
                165                 170                 175     
Cys Pro Ala Phe Ser Thr Pro Trp Glu Val Lys Glu Asp Asn Asn Gly 
            180                 185                 190         
Arg Ile Tyr Leu His Gly Pro Glu Val Leu Ala Asn Ile Ala Glu Thr 
        195                 200                 205             
Ile Gln Met Ser Tyr Ser Asn Asn Asn Pro Leu Ser Glu Val Ala Phe 
    210                 215                 220                 
Gly His Ala Lys Thr Ala Ala Glu Val Ala Ala Leu Met Pro Leu Leu 
225                 230                 235                 240 
Thr Ala Lys Tyr Asp Phe Thr Asn Asp Leu Pro Tyr Val Ala Arg Arg 
                245                 250                 255     
Gly Ala Ser Val Leu Met Asn Gln Ile Ala Leu Ala Leu Asn Thr Glu 
            260                 265                 270         
His Gln Ala Asp Ala Pro Pro Asp Ala Lys Trp Leu Leu Tyr Val Ala 
        275                 280                 285             
His Asp Thr Asn Ile Ala Tyr Leu Arg Thr Met Leu Gly Phe Thr Trp 
    290                 295                 300                 
Gln Met Gly Asp Tyr Pro Arg Gly Asn Ile Pro Pro Ala Gly Ser Leu 
305                 310                 315                 320 
Ile Phe Glu Arg Trp Arg Asn Gln Gln Ser Gly Gln Arg Val Val Arg 
                325                 330                 335     
Ile Tyr Phe Gln Ala Gln Ser Leu Asp Gln Ile Arg Gly Leu Ala Ala 
            340                 345                 350         
Leu Asp Asp Ser His Pro Pro Leu Arg Ser Glu Phe Ser Met Pro Asp 
        355                 360                 365             
Cys Gln Lys Thr Asp Ile Gly Thr Leu Cys Pro Tyr Asp Ala Val Met 
    370                 375                 380                 
Lys Arg Leu Asn Asp Ala Val Asp Arg Thr Ala Leu Leu Pro Val His 
385                 390                 395                 400 
Tyr Thr Pro His His His His His His 
                405                 

<210> 26
<211> 409
<212> PRT
<213> Artificial Sequence


<220> 
<223> Variant of wt sequence (Seq2)

<400> 26
Asp Thr Pro Ser Ser Gly Trp Thr Leu Glu Lys Val Val Glu Val Ser 
1               5                   10                  15      
Arg His Gly Val Arg Pro Pro Thr Glu Ser Asn Val Lys Glu Ile Gln 
            20                  25                  30          
Glu Gly Thr Asp Arg Gln Trp Pro Thr Trp Leu Thr Gln Tyr Gly Glu 
        35                  40                  45              
Leu Thr Gly His Gly Tyr Ala Ala Ala Val Leu Lys Gly His Tyr Glu 
    50                  55                  60                  
Gly Gln Tyr Leu Arg Gln His Gly Leu Leu Cys Gln Ala Cys Pro Ala 
65                  70                  75                  80  
Pro Gly Asp Val Phe Val Trp Ala Ser Pro Leu Gln Arg Thr Arg Glu 
                85                  90                  95      
Thr Ala Met Ala Leu Met Asp Gly Val Phe Pro Gly Cys Gly Val Ala 
            100                 105                 110         
Ile Gln Gly Pro Glu Asp Glu Lys Asn Asp Pro Leu Phe His Ala Glu 
        115                 120                 125             
Thr Ala Gly Val Thr Leu Asp Gln Gln Gln Val Lys Ala Asp Leu Gln 
    130                 135                 140                 
Asn Ala Met Gln Asn Lys Ser Ala Ala Gln Ile Gln Ala Gln Trp Gln 
145                 150                 155                 160 
Pro Ala Ile Asp Arg Leu Lys Gln Ala Val Cys Leu Pro Asp Lys Pro 
                165                 170                 175     
Cys Pro Ala Phe Ser Thr Pro Trp Glu Val Lys Glu Asp Asn Asn Gly 
            180                 185                 190         
Lys Ile Tyr Leu His Gly Pro Glu Val Leu Ala Ser Ile Ala Glu Thr 
        195                 200                 205             
Ile Gln Met Ser Tyr Ser Asn Asn Asn Pro Leu Ser Glu Val Ala Phe 
    210                 215                 220                 
Gly His Ala Lys Thr Ala Ala Glu Val Ala Ala Leu Met Pro Leu Leu 
225                 230                 235                 240 
Thr Ala Lys Tyr Asp Phe Thr Asn Asp Leu Pro Tyr Val Ala Arg Arg 
                245                 250                 255     
Gly Ala Ser Val Leu Met Asn Gln Ile Ala Leu Ala Leu Asn Thr Glu 
            260                 265                 270         
His Gln Ala Asp Ala Pro Pro Asp Ala Lys Trp Leu Leu Tyr Val Ala 
        275                 280                 285             
His Asp Thr Asn Ile Ala Tyr Leu Arg Thr Met Leu Gly Phe Thr Trp 
    290                 295                 300                 
Gln Met Gly Asp Tyr Pro Arg Gly Asn Ile Pro Pro Ala Gly Ser Leu 
305                 310                 315                 320 
Ile Phe Glu Arg Trp Arg Asn Gln Gln Ser Gly Gln Arg Val Val Arg 
                325                 330                 335     
Ile Tyr Phe Gln Ala Gln Ser Leu Asp Gln Ile Arg Gly Leu Ala Ala 
            340                 345                 350         
Leu Asp Asp Ser His Pro Pro Leu Arg Ser Glu Phe Ser Met Pro Asp 
        355                 360                 365             
Cys Gln Lys Thr Asp Ile Gly Thr Leu Cys Pro Tyr Asp Ala Val Met 
    370                 375                 380                 
Lys Arg Leu Asn Asp Ala Val Asp Arg Thr Ala Leu Leu Pro Val His 
385                 390                 395                 400 
Tyr Thr Pro His His His His His His 
                405                 

<210> 27
<211> 409
<212> PRT
<213> Artificial Sequence


<220> 
<223> Variant of wt sequence (Seq2)

<400> 27
Asp Thr Pro Ser Ser Gly Trp Thr Leu Glu Lys Val Val Glu Val Ser 
1               5                   10                  15      
Arg His Gly Val Arg Pro Pro Thr Glu Ser Asn Val Lys Thr Ile Gln 
            20                  25                  30          
Glu Gly Thr Asp Arg Gln Trp Pro Thr Trp Leu Thr Gln Tyr Gly Glu 
        35                  40                  45              
Leu Thr Gly His Gly Tyr Ala Ala Ala Val Leu Lys Gly His Tyr Glu 
    50                  55                  60                  
Gly Gln Tyr Leu Arg Gln His Gly Leu Leu Cys Gln Ala Cys Pro Ala 
65                  70                  75                  80  
Pro Gly Asp Val Phe Val Trp Ala Ser Pro Leu Gln Arg Thr Arg Glu 
                85                  90                  95      
Thr Ala Met Ala Leu Met Asp Gly Val Phe Pro Gly Cys Gly Val Ala 
            100                 105                 110         
Ile Gln Gly Pro Glu Asp Glu Asp Asn Asp Pro Leu Phe His Ala Glu 
        115                 120                 125             
Lys Ala Gly Val Thr Leu Asp Gln Gln Gln Val Lys Ala Asp Leu Gln 
    130                 135                 140                 
Asn Ala Met Gln Asn Lys Ser Ala Ala Gln Ile Gln Ala Gln Trp Gln 
145                 150                 155                 160 
Pro Ala Ile Asp Arg Leu Lys Gln Ala Val Cys Leu Pro Asp Lys Pro 
                165                 170                 175     
Cys Pro Ala Phe Ser Thr Pro Trp Glu Val Lys Glu Asp Asn Asn Gly 
            180                 185                 190         
Ser Ile Ser Leu His Gly Pro Glu Val Leu Ala Ile Ile Ala Glu Thr 
        195                 200                 205             
Ile Gln Met Ser Tyr Ser Asn Asn Asn Pro Leu Ser Glu Val Ala Phe 
    210                 215                 220                 
Gly His Ala Lys Thr Ala Ala Glu Val Ala Ala Leu Met Pro Leu Leu 
225                 230                 235                 240 
Thr Ala Asn Tyr Asp Phe Thr Asn Asp Leu Pro Tyr Val Ala Arg Arg 
                245                 250                 255     
Gly Ala Ser Val Leu Met Asn Gln Ile Ala Leu Ala Leu Asn Thr Glu 
            260                 265                 270         
His Gln Ala Asp Ala Pro Pro Asp Ala Lys Trp Leu Leu Tyr Val Ala 
        275                 280                 285             
His Asp Thr Asn Ile Ala Lys Leu Arg Thr Met Leu Gly Phe Thr Trp 
    290                 295                 300                 
Gln Met Gly Asp Tyr Pro Arg Gly Asn Ile Pro Pro Ala Gly Ser Leu 
305                 310                 315                 320 
Ile Phe Glu Arg Trp Arg Asn Gln Gln Ser Gly Gln Arg Val Val Arg 
                325                 330                 335     
Ile Tyr Phe Gln Ala Gln Ser Leu Asp Gln Ile Arg Gly Leu Ala Ala 
            340                 345                 350         
Leu Asp Asp Ser His Pro Pro Leu Arg Ser Glu Phe Ser Met Pro Asp 
        355                 360                 365             
Cys Gln Lys Thr Asp Ile Gly Thr Leu Cys Pro Tyr Asp Ala Val Met 
    370                 375                 380                 
Lys Arg Leu Asn Asp Ala Val Asp Arg Thr Ala Leu Leu Pro Val His 
385                 390                 395                 400 
Tyr Thr Pro His His His His His His 
                405                 

<210> 28
<211> 409
<212> PRT
<213> Artificial Sequence


<220> 
<223> Variant of wt sequence (Seq2)

<400> 28
Asp Thr Pro Ser Ser Gly Trp Thr Leu Glu Lys Val Val Glu Val Ser 
1               5                   10                  15      
Arg His Gly Val Arg Pro Pro Thr Glu Ser Asn Val Lys Thr Ile Gln 
            20                  25                  30          
Glu Gly Thr Asn Arg Gln Trp Pro Thr Trp Leu Thr Gln Tyr Gly Glu 
        35                  40                  45              
Leu Thr Gly His Gly Tyr Ala Ala Ala Val Leu Lys Gly His Tyr Glu 
    50                  55                  60                  
Gly Gln Tyr Leu Arg Gln His Gly Leu Leu Cys Gln Ala Cys Pro Ala 
65                  70                  75                  80  
Pro Gly Asp Val Phe Val Trp Ala Ser Pro Leu Gln Arg Thr Arg Glu 
                85                  90                  95      
Thr Ala Met Ala Leu Met Asp Gly Val Phe Pro Gly Cys Gly Val Ala 
            100                 105                 110         
Ile Gln Gly Pro Glu Asp Glu Lys Asn Asp Pro Leu Phe His Ala Glu 
        115                 120                 125             
Thr Ala Gly Val Thr Leu Asp Gln Gln Gln Val Lys Ala Asp Leu Gln 
    130                 135                 140                 
Asn Ala Met Gln Asn Lys Ser Ala Ala Gln Ile Gln Ala Gln Trp Gln 
145                 150                 155                 160 
Pro Ala Ile Asp Arg Leu Lys Gln Ala Val Cys Leu Pro Asp Lys Pro 
                165                 170                 175     
Cys Pro Ala Phe Ser Thr Pro Trp Glu Val Lys Glu Asp Asn Asn Gly 
            180                 185                 190         
Arg Ile Tyr Leu His Gly Pro Glu Val Leu Ala Asn Ile Ala Glu Thr 
        195                 200                 205             
Ile Gln Met Ser Tyr Ser Asn Asn Asn Pro Leu Ser Glu Val Ala Phe 
    210                 215                 220                 
Gly His Ala Lys Thr Ala Ala Glu Val Ala Ala Leu Met Pro Leu Leu 
225                 230                 235                 240 
Thr Ala Lys Tyr Asp Phe Thr Asn Asp Leu Pro Tyr Val Ala Arg Arg 
                245                 250                 255     
Gly Ala Ser Val Leu Met Asn Gln Ile Ala Leu Ala Leu Asn Thr Glu 
            260                 265                 270         
His Gln Ala Asp Ala Pro Pro Asp Ala Lys Trp Leu Leu Tyr Val Ala 
        275                 280                 285             
His Asp Thr Asn Ile Ala Tyr Leu Arg Thr Met Leu Gly Phe Thr Trp 
    290                 295                 300                 
Gln Met Gly Asp Tyr Pro Arg Gly Asn Ile Pro Pro Ala Gly Ser Leu 
305                 310                 315                 320 
Ile Phe Glu Arg Trp Arg Asn Gln Gln Ser Gly Gln Arg Val Val Arg 
                325                 330                 335     
Ile Tyr Phe Gln Ala Gln Ser Leu Asp Gln Ile Arg Gly Leu Ala Ala 
            340                 345                 350         
Leu Asp Asp Ser His Pro Pro Leu Arg Ser Glu Phe Ser Met Pro Asp 
        355                 360                 365             
Cys Gln Lys Thr Asp Ile Gly Thr Leu Cys Pro Tyr Asp Ala Val Met 
    370                 375                 380                 
Lys Arg Leu Asn Asp Ala Val Asp Arg Thr Ala Leu Leu Pro Val His 
385                 390                 395                 400 
Tyr Thr Pro His His His His His His 
                405                 

<210> 29
<211> 409
<212> PRT
<213> Artificial Sequence


<220> 
<223> Variant of wt sequence (Seq2)

<400> 29
Asp Thr Pro Ser Ser Gly Trp Thr Leu Glu Lys Val Val Glu Val Ser 
1               5                   10                  15      
Arg His Gly Val Arg Pro Pro Thr Glu Ser Asn Val Lys Ala Ile Gln 
            20                  25                  30          
Glu Gly Thr Asp Arg Gln Trp Pro Thr Trp Leu Thr Gln Tyr Gly Glu 
        35                  40                  45              
Leu Thr Gly His Gly Tyr Ala Ala Ala Val Leu Lys Gly His Tyr Glu 
    50                  55                  60                  
Gly Gln Tyr Leu Arg Gln His Gly Leu Leu Cys Gln Ala Cys Pro Ala 
65                  70                  75                  80  
Pro Gly Asp Val Phe Val Trp Ala Ser Pro Leu Gln Arg Thr Arg Glu 
                85                  90                  95      
Thr Ala Met Ala Leu Met Asp Gly Val Phe Pro Gly Cys Gly Val Ala 
            100                 105                 110         
Ile Gln Gly Pro Glu Asp Glu Asp Asn Asp Pro Leu Phe His Ala Glu 
        115                 120                 125             
Lys Ala Gly Val Thr Leu Asp Gln Gln Gln Val Lys Ala Asp Leu Gln 
    130                 135                 140                 
Asn Ala Met Gln Asn Lys Ser Ala Ala Gln Ile Gln Ala Gln Trp Gln 
145                 150                 155                 160 
Pro Ala Ile Asp Arg Leu Lys Gln Ala Val Cys Leu Pro Asp Lys Pro 
                165                 170                 175     
Cys Pro Ala Phe Ser Thr Pro Trp Glu Val Lys Glu Asp Asn Asn Gly 
            180                 185                 190         
Arg Ile Tyr Leu His Gly Pro Glu Val Leu Ala Asn Ile Ala Glu Thr 
        195                 200                 205             
Ile Gln Met Ser Tyr Ser Asn Asn Asn Pro Leu Ser Glu Val Ala Phe 
    210                 215                 220                 
Gly His Ala Lys Thr Ala Ala Glu Val Ala Ala Leu Met Pro Leu Leu 
225                 230                 235                 240 
Thr Ala Lys Tyr Asp Phe Thr Asn Asp Leu Pro Tyr Val Ala Arg Arg 
                245                 250                 255     
Gly Ala Ser Val Leu Met Asn Gln Ile Ala Leu Ala Leu Asn Thr Glu 
            260                 265                 270         
His Gln Ala Asp Ala Pro Pro Asp Ala Lys Trp Leu Leu Tyr Val Ala 
        275                 280                 285             
His Asp Thr Asn Ile Ala Tyr Leu Arg Thr Met Leu Gly Phe Thr Trp 
    290                 295                 300                 
Gln Met Gly Asp Tyr Pro Arg Gly Asn Ile Pro Pro Ala Gly Ser Leu 
305                 310                 315                 320 
Ile Phe Glu Arg Trp Arg Asn Gln Gln Ser Gly Gln Arg Val Val Arg 
                325                 330                 335     
Ile Tyr Phe Gln Ala Gln Ser Leu Asp Gln Ile Arg Gly Leu Ala Ala 
            340                 345                 350         
Leu Asp Asp Ser His Pro Pro Leu Arg Ser Glu Phe Ser Met Pro Asp 
        355                 360                 365             
Cys Gln Lys Thr Asp Ile Gly Thr Leu Cys Pro Tyr Asp Ala Val Met 
    370                 375                 380                 
Lys Arg Leu Asn Asp Ala Val Asp Arg Thr Ala Leu Leu Pro Val His 
385                 390                 395                 400 
Tyr Thr Pro His His His His His His 
                405                 

<210> 30
<211> 409
<212> PRT
<213> Artificial Sequence


<220> 
<223> Variant of wt sequence (Seq2)

<400> 30
Asp Thr Pro Ser Ser Gly Trp Thr Leu Glu Lys Val Val Glu Val Ser 
1               5                   10                  15      
Arg His Gly Val Arg Pro Pro Thr Glu Ser Asn Val Lys Thr Ile Gln 
            20                  25                  30          
Glu Gly Thr Asn Arg Gln Trp Pro Thr Trp Leu Thr Gln Tyr Gly Glu 
        35                  40                  45              
Leu Thr Gly His Gly Tyr Ala Ala Ala Val Leu Lys Gly His Tyr Glu 
    50                  55                  60                  
Gly Gln Tyr Leu Arg Gln His Gly Leu Leu Cys Gln Ala Cys Pro Ala 
65                  70                  75                  80  
Pro Gly Asp Val Phe Val Trp Ala Ser Pro Leu Gln Arg Thr Arg Glu 
                85                  90                  95      
Thr Ala Met Ala Leu Met Asp Gly Val Phe Pro Gly Cys Gly Val Ala 
            100                 105                 110         
Ile Gln Gly Pro Glu Asp Glu Asp Asn Asp Pro Leu Phe His Ala Glu 
        115                 120                 125             
Lys Ala Gly Val Thr Leu Asp Gln Gln Gln Val Lys Ala Asp Leu Gln 
    130                 135                 140                 
Asn Ala Met Gln Asn Lys Ser Ala Ala Gln Ile Gln Ala Gln Trp Gln 
145                 150                 155                 160 
Pro Ala Ile Asp Arg Leu Lys Gln Ala Val Cys Leu Pro Asp Lys Pro 
                165                 170                 175     
Cys Pro Ala Phe Ser Thr Pro Trp Glu Val Lys Glu Asp Asn Asn Gly 
            180                 185                 190         
Arg Ile Tyr Leu His Gly Pro Glu Val Leu Ala Asn Ile Ala Glu Thr 
        195                 200                 205             
Ile Gln Met Ser Tyr Ser Asn Asn Asn Pro Leu Ser Glu Val Ala Phe 
    210                 215                 220                 
Gly His Ala Lys Thr Ala Ala Glu Val Ala Ala Leu Met Pro Leu Leu 
225                 230                 235                 240 
Thr Ala Lys Tyr Asp Phe Thr Asn Asp Leu Pro Tyr Val Ala Arg Arg 
                245                 250                 255     
Gly Ala Ser Val Leu Met Asn Gln Ile Ala Leu Ala Leu Asn Thr Glu 
            260                 265                 270         
His Gln Ala Asp Ala Pro Pro Asp Ala Lys Trp Leu Leu Tyr Val Ala 
        275                 280                 285             
His Asp Thr Asn Ile Ala Tyr Leu Arg Thr Met Leu Gly Phe Thr Trp 
    290                 295                 300                 
Gln Met Gly Asp Tyr Pro Arg Gly Asn Ile Pro Pro Ala Gly Ser Leu 
305                 310                 315                 320 
Ile Phe Glu Arg Trp Arg Asn Gln Gln Ser Gly Gln Arg Val Val Arg 
                325                 330                 335     
Ile Tyr Phe Gln Ala Gln Ser Leu Asp Gln Ile Arg Gly Leu Ala Ala 
            340                 345                 350         
Leu Asp Asp Ser His Pro Pro Leu Arg Ser Glu Phe Ser Met Pro Asp 
        355                 360                 365             
Cys Gln Lys Thr Asp Ile Gly Thr Leu Cys Pro Tyr Asp Ala Val Met 
    370                 375                 380                 
Lys Arg Leu Asn Asp Ala Val Asp Arg Thr Ala Leu Leu Pro Val His 
385                 390                 395                 400 
Tyr Thr Pro His His His His His His 
                405                 

<210> 31
<211> 409
<212> PRT
<213> Artificial Sequence


<220> 
<223> Variant of wt sequence (Seq2)

<400> 31
Asp Thr Pro Ser Ser Gly Trp Thr Leu Glu Lys Val Val Glu Val Ser 
1               5                   10                  15      
Arg His Gly Val Arg Pro Pro Thr Glu Ser Asn Val Lys Thr Ile Gln 
            20                  25                  30          
Glu Gly Thr Asp Arg Gln Trp Pro Thr Trp Leu Thr Gln Tyr Gly Glu 
        35                  40                  45              
Leu Thr Gly His Gly Tyr Ala Ala Ala Val Leu Lys Gly His Tyr Glu 
    50                  55                  60                  
Gly Gln Tyr Leu Arg Gln His Gly Leu Leu Cys Gln Ala Cys Pro Ala 
65                  70                  75                  80  
Pro Gly Asp Val Phe Val Trp Ala Ser Pro Leu Gln Arg Thr Arg Glu 
                85                  90                  95      
Thr Ala Met Ala Leu Met Asp Gly Val Phe Pro Gly Cys Gly Val Ala 
            100                 105                 110         
Ile Gln Gly Pro Glu Asp Glu Asp Asn Asp Pro Leu Phe His Ala Glu 
        115                 120                 125             
Lys Ala Gly Val Thr Leu Asp Gln Gln Gln Val Lys Ala Asp Leu Gln 
    130                 135                 140                 
Asn Ala Met Gln Asn Lys Ser Ala Ala Gln Ile Gln Ala Gln Trp Gln 
145                 150                 155                 160 
Pro Ala Ile Asp Arg Leu Lys Gln Ala Val Cys Leu Pro Asp Lys Pro 
                165                 170                 175     
Cys Pro Ala Phe Ser Thr Pro Trp Glu Val Lys Glu Asp Asn Asn Gly 
            180                 185                 190         
Arg Ile Tyr Leu His Gly Pro Glu Val Leu Ala Asn Ile Ala Glu Thr 
        195                 200                 205             
Ile Gln Met Ser Tyr Ser Asn Asn Asn Pro Leu Ser Glu Val Ala Phe 
    210                 215                 220                 
Gly His Ala Lys Thr Ala Ala Glu Val Ala Ala Leu Met Pro Leu Leu 
225                 230                 235                 240 
Thr Ala Lys Tyr Asp Phe Thr Asn Asp Leu Pro Tyr Val Ala Arg Arg 
                245                 250                 255     
Gly Ala Ser Val Leu Met Asn Gln Ile Ala Leu Ala Leu Asn Thr Glu 
            260                 265                 270         
His Gln Ala Asp Ala Pro Pro Asp Ala Lys Trp Leu Leu Tyr Val Ala 
        275                 280                 285             
His Asp Thr Asn Ile Ala Tyr Leu Arg Thr Met Leu Gly Phe Thr Trp 
    290                 295                 300                 
Gln Met Gly Asp Tyr Pro Arg Gly Asn Ile Pro Pro Ala Gly Ser Leu 
305                 310                 315                 320 
Ile Phe Glu Arg Trp Arg Asn Gln Gln Ser Gly Gln Arg Val Val Arg 
                325                 330                 335     
Ile Tyr Phe Gln Ala Gln Ser Leu Asp Gln Ile Arg Gly Leu Ala Ala 
            340                 345                 350         
Leu Asp Asp Ser His Pro Pro Leu Arg Ser Glu Phe Ser Met Pro Asp 
        355                 360                 365             
Cys Gln Lys Thr Asp Ile Gly Thr Leu Cys Pro Tyr Asp Ala Val Met 
    370                 375                 380                 
Lys Arg Leu Asn Asp Ala Val Asp Arg Thr Ala Leu Leu Pro Val His 
385                 390                 395                 400 
Tyr Thr Pro His His His His His His 
                405                 

<210> 32
<211> 409
<212> PRT
<213> Artificial Sequence


<220> 
<223> Variant of wt sequence (Seq2)

<400> 32
Asp Thr Pro Ser Ser Gly Trp Thr Leu Glu Lys Val Val Glu Val Ser 
1               5                   10                  15      
Arg His Gly Val Arg Pro Pro Thr Glu Asn Asn Val Lys Thr Ile Gln 
            20                  25                  30          
Glu Gly Thr Asn Arg Gln Trp Pro Thr Trp Leu Thr Gln Tyr Gly Glu 
        35                  40                  45              
Leu Thr Gly His Gly Tyr Ala Ala Ala Val Leu Lys Gly His Tyr Glu 
    50                  55                  60                  
Gly Gln Tyr Leu Arg Gln His Gly Leu Leu Cys Gln Ala Cys Pro Ala 
65                  70                  75                  80  
Pro Gly Asp Val Phe Val Trp Ala Ser Pro Leu Gln Arg Thr Arg Glu 
                85                  90                  95      
Thr Ala Met Ala Leu Met Asp Gly Val Phe Pro Gly Cys Gly Val Ala 
            100                 105                 110         
Ile Gln Gly Pro Glu Asp Glu Asp Asn Asp Pro Leu Phe His Ala Glu 
        115                 120                 125             
Lys Ala Gly Val Thr Leu Asp Gln Gln Gln Val Lys Ala Asp Leu Gln 
    130                 135                 140                 
Asn Ala Met Gln Asn Lys Ser Ala Ala Gln Ile Gln Ala Gln Trp Gln 
145                 150                 155                 160 
Pro Ala Ile Asp Arg Leu Lys Gln Ala Val Cys Leu Pro Asp Lys Pro 
                165                 170                 175     
Cys Pro Ala Phe Ser Thr Pro Trp Glu Val Lys Glu Asp Asn Asn Gly 
            180                 185                 190         
Ser Ile Ser Leu His Gly Pro Glu Val Leu Ala Ile Ile Ala Glu Thr 
        195                 200                 205             
Ile Gln Met Ser Tyr Ser Asn Asn Asn Pro Leu Ser Glu Val Ala Phe 
    210                 215                 220                 
Gly His Ala Lys Thr Ala Ala Glu Val Ala Ala Leu Met Pro Leu Leu 
225                 230                 235                 240 
Thr Ala Asn Tyr Asp Phe Thr Asn Asp Leu Pro Tyr Val Ala Arg Arg 
                245                 250                 255     
Gly Ala Ser Val Leu Met Asn Gln Ile Ala Leu Ala Leu Asn Thr Glu 
            260                 265                 270         
His Gln Ala Asp Ala Pro Pro Asp Ala Lys Trp Leu Leu Tyr Val Ala 
        275                 280                 285             
His Asp Thr Asn Ile Ala Lys Leu Arg Thr Met Leu Gly Phe Thr Trp 
    290                 295                 300                 
Gln Met Gly Asp Tyr Pro Arg Gly Asn Ile Pro Pro Ala Gly Ser Leu 
305                 310                 315                 320 
Ile Phe Glu Arg Trp Arg Asn Gln Gln Ser Gly Gln Arg Val Val Arg 
                325                 330                 335     
Ile Tyr Phe Gln Ala Gln Ser Leu Asp Gln Ile Arg Gly Leu Ala Ala 
            340                 345                 350         
Leu Asp Asp Ser His Pro Pro Leu Arg Ser Glu Phe Ser Met Pro Asp 
        355                 360                 365             
Cys Gln Lys Thr Asp Ile Gly Thr Leu Cys Pro Tyr Asp Ala Val Met 
    370                 375                 380                 
Lys Arg Leu Asn Asp Ala Val Asp Arg Thr Ala Leu Leu Pro Val His 
385                 390                 395                 400 
Tyr Thr Pro His His His His His His 
                405                 

<210> 33
<211> 409
<212> PRT
<213> Artificial Sequence


<220> 
<223> Variant of wt sequence (Seq2)

<400> 33
Asp Thr Pro Ser Ser Gly Trp Thr Leu Glu Lys Val Val Glu Val Ser 
1               5                   10                  15      
Arg His Gly Val Arg Pro Pro Thr Ala Ser Asn Val Lys Lys Ile Gln 
            20                  25                  30          
Glu Gly Thr Asp Arg Gln Trp Pro Thr Trp Leu Thr Gln Tyr Gly Glu 
        35                  40                  45              
Leu Thr Gly His Gly Tyr Ala Ala Ala Val Leu Lys Gly His Tyr Glu 
    50                  55                  60                  
Gly Gln Tyr Leu Arg Gln His Gly Leu Leu Cys Gln Ala Cys Pro Ala 
65                  70                  75                  80  
Pro Gly Asp Val Phe Val Trp Ala Ser Pro Leu Gln Arg Thr Arg Glu 
                85                  90                  95      
Thr Ala Met Ala Leu Met Asp Gly Val Phe Pro Gly Cys Gly Val Ala 
            100                 105                 110         
Ile Gln Gly Pro Glu Asp Glu Asp Asn Asp Pro Leu Phe His Ala Glu 
        115                 120                 125             
Thr Ala Gly Val Thr Leu Asp Gln Gln Gln Val Lys Ala Asp Leu Gln 
    130                 135                 140                 
Asn Ala Met Gln Asn Lys Ser Ala Ala Gln Ile Gln Ala Gln Trp Gln 
145                 150                 155                 160 
Pro Ala Ile Asp Arg Leu Lys Gln Ala Val Cys Leu Pro Asp Lys Pro 
                165                 170                 175     
Cys Pro Ala Phe Ser Thr Pro Trp Glu Val Lys Glu Asp Asn Asn Gly 
            180                 185                 190         
His Ile Ser Leu His Gly Pro Glu Val Leu Ala Ile Ile Ala Glu Thr 
        195                 200                 205             
Ile Gln Met Ser Tyr Ser Asn Asn Asn Pro Leu Ser Glu Val Ala Phe 
    210                 215                 220                 
Gly His Ala Lys Thr Ala Ala Glu Val Ala Ala Leu Met Pro Leu Leu 
225                 230                 235                 240 
Thr Ala Asn Tyr Asp Phe Thr Asn Asp Leu Pro Tyr Val Ala Arg Arg 
                245                 250                 255     
Gly Ala Ser Val Leu Met Asn Gln Ile Ala Leu Ala Leu Asn Thr Glu 
            260                 265                 270         
His Gln Ala Asp Ala Pro Pro Asp Ala Lys Trp Leu Leu Tyr Val Ala 
        275                 280                 285             
His Asp Thr Asn Ile Ala Lys Leu Arg Thr Met Leu Gly Phe Thr Trp 
    290                 295                 300                 
Gln Met Gly Asp Tyr Pro Arg Gly Asn Ile Pro Pro Ala Gly Ser Leu 
305                 310                 315                 320 
Ile Phe Glu Arg Trp Arg Asn Gln Gln Ser Gly Gln Arg Val Val Arg 
                325                 330                 335     
Ile Tyr Phe Gln Ala Gln Ser Leu Asp Gln Ile Arg Gly Leu Ala Ala 
            340                 345                 350         
Leu Asp Asp Ser His Pro Pro Leu Arg Ser Glu Phe Ser Met Pro Asp 
        355                 360                 365             
Cys Gln Lys Thr Asp Ile Gly Thr Leu Cys Pro Tyr Asp Ala Val Met 
    370                 375                 380                 
Lys Arg Leu Asn Asp Ala Val Asp Arg Thr Ala Leu Leu Pro Val His 
385                 390                 395                 400 
Tyr Thr Pro His His His His His His 
                405                 

<210> 34
<211> 409
<212> PRT
<213> Artificial Sequence


<220> 
<223> Variant of wt sequence (Seq2)

<400> 34
Asp Thr Pro Ser Ser Gly Trp Thr Leu Glu Lys Val Val Glu Val Ser 
1               5                   10                  15      
Arg His Gly Val Arg Pro Pro Thr Glu Ser Asn Val Lys Thr Ile Gln 
            20                  25                  30          
Glu Gly Thr Asp Arg Gln Trp Pro Thr Trp Leu Thr Gln Tyr Gly Glu 
        35                  40                  45              
Leu Thr Gly His Gly Tyr Ala Ala Ala Glu Leu Lys Gly His Tyr Glu 
    50                  55                  60                  
Gly Gln Tyr Leu Arg Gln His Gly Leu Leu Cys Gln Ala Cys Pro Ala 
65                  70                  75                  80  
Pro Gly Asp Val Phe Val Trp Ala Ser Pro Leu Gln Arg Thr Arg Glu 
                85                  90                  95      
Thr Ala Met Ala Leu Met Asp Gly Val Phe Pro Gly Cys Gly Val Ala 
            100                 105                 110         
Ile Gln Gly Pro Glu Asp Glu Asp Asn Asp Pro Leu Phe His Ala Glu 
        115                 120                 125             
Lys Ala Gly Val Thr Leu Asp Gln Gln Gln Val Lys Ala Asp Leu Gln 
    130                 135                 140                 
Asn Ala Met Gln Asn Lys Ser Ala Ala Gln Ile Gln Ala Gln Trp Gln 
145                 150                 155                 160 
Pro Ala Ile Asp Arg Leu Lys Gln Ala Val Cys Leu Pro Asp Lys Pro 
                165                 170                 175     
Cys Pro Ala Phe Ser Thr Pro Trp Glu Val Lys Glu Asp Asn Asn Gly 
            180                 185                 190         
Arg Ile Tyr Leu His Gly Pro Glu Val Leu Ala Asn Ile Ala Glu Thr 
        195                 200                 205             
Ile Gln Met Ser Tyr Ser Asn Asn Asn Pro Leu Ser Glu Val Ala Phe 
    210                 215                 220                 
Gly His Ala Lys Thr Ala Ala Glu Val Ala Ala Leu Met Pro Leu Leu 
225                 230                 235                 240 
Thr Ala Lys Tyr Asp Phe Thr Asn Asp Leu Pro Tyr Val Ala Arg Arg 
                245                 250                 255     
Gly Ala Ser Val Leu Met Asn Gln Ile Ala Leu Ala Leu Asn Thr Glu 
            260                 265                 270         
His Gln Ala Asp Ala Pro Pro Asp Ala Lys Trp Leu Leu Tyr Val Ala 
        275                 280                 285             
His Asp Thr Asn Ile Ala Tyr Leu Arg Thr Met Leu Gly Phe Thr Trp 
    290                 295                 300                 
Gln Met Gly Asp Tyr Pro Arg Gly Asn Ile Pro Pro Ala Gly Ser Leu 
305                 310                 315                 320 
Ile Phe Glu Arg Trp Arg Asn Gln Gln Ser Gly Gln Arg Val Val Arg 
                325                 330                 335     
Ile Tyr Phe Gln Ala Gln Ser Leu Asp Gln Ile Arg Gly Leu Ala Ala 
            340                 345                 350         
Leu Asp Asp Ser His Pro Pro Leu Arg Ser Glu Phe Ser Met Pro Asp 
        355                 360                 365             
Cys Gln Lys Thr Asp Ile Gly Thr Leu Cys Pro Tyr Asp Ala Val Met 
    370                 375                 380                 
Lys Arg Leu Asn Asp Ala Val Asp Arg Thr Ala Leu Leu Pro Val His 
385                 390                 395                 400 
Tyr Thr Pro His His His His His His 
                405                 

<210> 35
<211> 409
<212> PRT
<213> Artificial Sequence


<220> 
<223> Variant of wt sequence (Seq2)

<400> 35
Asp Thr Pro Ser Ser Gly Trp Thr Leu Glu Lys Val Val Glu Val Ser 
1               5                   10                  15      
Arg His Gly Val Arg Pro Pro Thr Glu Asn Asn Val Lys Thr Ile Gln 
            20                  25                  30          
Glu Gly Thr Asn Arg Gln Trp Pro Thr Trp Leu Thr Gln Tyr Gly Glu 
        35                  40                  45              
Leu Thr Gly His Gly Tyr Ala Ala Ala Val Leu Lys Gly His Tyr Glu 
    50                  55                  60                  
Gly Gln Tyr Leu Arg Gln His Gly Leu Leu Cys Gln Ala Cys Pro Ala 
65                  70                  75                  80  
Pro Gly Asp Val Phe Val Trp Ala Ser Pro Leu Gln Arg Thr Arg Glu 
                85                  90                  95      
Thr Ala Met Ala Leu Met Asp Gly Val Phe Ser Gly Cys Gly Val Ala 
            100                 105                 110         
Ile Gln Gly Pro Glu Asp Glu Asp Asn Asp Pro Leu Phe His Ala Glu 
        115                 120                 125             
Lys Ala Gly Val Thr Leu Asp Gln Gln Gln Val Lys Ala Asp Leu Gln 
    130                 135                 140                 
Asn Ala Met Gln Asn Lys Ser Ala Ala Gln Ile Gln Ala Gln Trp Gln 
145                 150                 155                 160 
Pro Ala Ile Asp Arg Leu Lys Gln Ala Val Cys Leu Pro Asp Lys Pro 
                165                 170                 175     
Cys Pro Ala Phe Ser Thr Pro Trp Glu Val Lys Glu Asp Asn Asn Gly 
            180                 185                 190         
Ser Ile Ser Leu His Gly Pro Glu Val Leu Ala Ile Ile Ala Glu Thr 
        195                 200                 205             
Ile Gln Met Ser Tyr Ser Asn Asn Asn Pro Leu Ser Glu Val Ala Phe 
    210                 215                 220                 
Gly His Ala Lys Thr Ala Ala Glu Val Ala Ala Leu Met Pro Leu Leu 
225                 230                 235                 240 
Thr Ala Asn Tyr Asp Phe Thr Asn Asp Leu Pro Tyr Val Ala Arg Arg 
                245                 250                 255     
Gly Ala Ser Val Leu Met Asn Gln Ile Ala Leu Ala Leu Asn Thr Glu 
            260                 265                 270         
His Gln Ala Asp Ala Pro Pro Asp Ala Lys Trp Leu Leu Tyr Val Ala 
        275                 280                 285             
His Asp Thr Asn Ile Ala Lys Leu Arg Thr Met Leu Gly Phe Thr Trp 
    290                 295                 300                 
Gln Met Gly Asp Tyr Pro Arg Gly Asn Ile Pro Pro Ala Gly Ser Leu 
305                 310                 315                 320 
Ile Phe Glu Arg Trp Arg Asn Gln Gln Ser Gly Gln Arg Val Val Arg 
                325                 330                 335     
Ile Tyr Phe Gln Ala Gln Ser Leu Asp Gln Ile Arg Gly Leu Ala Ala 
            340                 345                 350         
Leu Asp Asp Ser His Pro Pro Leu Arg Ser Glu Phe Ser Met Pro Asp 
        355                 360                 365             
Cys Gln Lys Thr Asp Ile Gly Thr Leu Cys Pro Tyr Asp Ala Val Met 
    370                 375                 380                 
Lys Arg Leu Asn Asp Ala Val Asp Arg Thr Ala Leu Leu Pro Val His 
385                 390                 395                 400 
Tyr Thr Pro His His His His His His 
                405                 

<210> 36
<211> 409
<212> PRT
<213> Artificial Sequence


<220> 
<223> Variant of wt sequence (Seq2)

<400> 36
Asp Thr Pro Ser Ser Gly Trp Thr Leu Glu Lys Val Val Glu Val Ser 
1               5                   10                  15      
Arg His Gly Val Arg Pro Pro Thr Glu Ser Asn Val Lys Thr Ile Gln 
            20                  25                  30          
Glu Gly Thr Asp Arg Gln Trp Pro Thr Trp Leu Thr Gln Tyr Gly Glu 
        35                  40                  45              
Leu Thr Gly His Gly Tyr Ala Ala Ala Glu Leu Lys Gly His Tyr Glu 
    50                  55                  60                  
Gly Gln Tyr Leu Arg Gln His Gly Leu Leu Cys Gln Ala Cys Pro Ala 
65                  70                  75                  80  
Pro Gly Asp Val Phe Val Trp Ala Ser Pro Leu Gln Arg Thr Arg Glu 
                85                  90                  95      
Thr Ala Met Ala Leu Met Asp Gly Val Phe Pro Gly Cys Gly Val Ala 
            100                 105                 110         
Ile Gln Gly Pro Glu Asp Glu Asp Asn Asp Pro Leu Phe His Ala Glu 
        115                 120                 125             
Lys Ala Gly Val Thr Leu Asp Gln Gln Gln Val Lys Ala Asp Leu Gln 
    130                 135                 140                 
Asn Ala Met Gln Asn Lys Ser Ala Ala Gln Ile Gln Ala Gln Trp Gln 
145                 150                 155                 160 
Pro Ala Ile Asp Arg Leu Lys Gln Ala Val Cys Leu Pro Asp Lys Pro 
                165                 170                 175     
Cys Pro Ala Phe Ser Thr Pro Trp Glu Val Lys Glu Asp Asn Asn Gly 
            180                 185                 190         
Lys Ile Tyr Leu His Gly Pro Glu Val Leu Ala Ile Ile Ala Glu Thr 
        195                 200                 205             
Ile Gln Met Ser Tyr Ser Asn Asn Asn Pro Leu Ser Glu Val Ala Phe 
    210                 215                 220                 
Gly His Ala Lys Thr Ala Ala Glu Val Ala Ala Leu Met Pro Leu Leu 
225                 230                 235                 240 
Thr Ala Asn Tyr Asp Phe Thr Asn Asp Leu Pro Tyr Val Ala Arg Arg 
                245                 250                 255     
Gly Ala Ser Val Leu Met Asn Gln Ile Ala Leu Ala Leu Asn Thr Glu 
            260                 265                 270         
His Gln Ala Asp Ala Pro Pro Asp Ala Lys Trp Leu Leu Tyr Val Ala 
        275                 280                 285             
His Asp Thr Asn Ile Ala Lys Leu Arg Thr Met Leu Gly Phe Thr Trp 
    290                 295                 300                 
Gln Met Gly Asp Tyr Pro Arg Gly Asn Ile Pro Pro Ala Gly Ser Leu 
305                 310                 315                 320 
Ile Phe Glu Arg Trp Arg Asn Gln Gln Ser Gly Gln Arg Val Val Arg 
                325                 330                 335     
Ile Tyr Phe Gln Ala Gln Ser Leu Asp Gln Ile Arg Gly Leu Ala Ala 
            340                 345                 350         
Leu Asp Asp Ser His Pro Pro Leu Arg Ser Glu Phe Ser Met Pro Asp 
        355                 360                 365             
Cys Gln Lys Thr Asp Ile Gly Thr Leu Cys Pro Tyr Asp Ala Val Met 
    370                 375                 380                 
Lys Arg Leu Asn Asp Ala Val Asp Arg Thr Ala Leu Leu Pro Val His 
385                 390                 395                 400 
Tyr Thr Pro His His His His His His 
                405                 

<210> 37
<211> 409
<212> PRT
<213> Artificial Sequence


<220> 
<223> Variant of wt sequence (Seq2)

<400> 37
Asp Thr Pro Ser Ser Gly Trp Thr Leu Glu Lys Val Val Glu Val Ser 
1               5                   10                  15      
Arg His Gly Val Arg Pro Pro Thr Glu Ser Asn Val Lys Thr Ile Gln 
            20                  25                  30          
Glu Gly Thr Asp Arg Gln Trp Pro Thr Trp Leu Thr Gln Tyr Gly Glu 
        35                  40                  45              
Leu Thr Gly His Gly Tyr Ala Ala Ala Glu Leu Lys Gly His Tyr Glu 
    50                  55                  60                  
Gly Gln Tyr Leu Arg Gln His Gly Leu Leu Cys Gln Ala Cys Pro Ala 
65                  70                  75                  80  
Pro Gly Asp Val Phe Val Trp Ala Ser Pro Leu Gln Arg Thr Arg Glu 
                85                  90                  95      
Thr Ala Met Ala Leu Met Asp Gly Val Phe Pro Gly Cys Gly Val Ala 
            100                 105                 110         
Ile Gln Gly Pro Glu Asp Glu Asp Asn Asp Pro Leu Phe His Ala Glu 
        115                 120                 125             
Thr Ala Gly Val Thr Leu Asp Gln Gln Gln Val Lys Ala Asp Leu Gln 
    130                 135                 140                 
Asn Ala Met Gln Asn Lys Ser Ala Ala Gln Ile Gln Ala Gln Trp Gln 
145                 150                 155                 160 
Pro Ala Ile Asp Arg Leu Lys Gln Ala Val Cys Leu Pro Asp Lys Pro 
                165                 170                 175     
Cys Pro Ala Phe Ser Thr Pro Trp Glu Val Lys Glu Asp Asn Asn Gly 
            180                 185                 190         
Ser Ile Arg Leu His Gly Pro Glu Val Leu Ala Ile Ile Ala Glu Thr 
        195                 200                 205             
Ile Gln Met Ser Tyr Ser Asn Asn Asn Pro Leu Ser Glu Val Ala Phe 
    210                 215                 220                 
Gly His Ala Lys Thr Ala Ala Glu Val Ala Ala Leu Leu Pro Leu Leu 
225                 230                 235                 240 
Thr Ala Asn Tyr Asp Phe Thr Asn Asp Leu Pro Tyr Val Ala Arg Arg 
                245                 250                 255     
Gly Ala Ser Val Leu Met Asn Gln Ile Ala Leu Ala Leu Asn Thr Glu 
            260                 265                 270         
His Gln Ala Asp Ala Pro Pro Asp Ala Lys Trp Leu Leu Tyr Val Ala 
        275                 280                 285             
His Asp Thr Asn Ile Ala Lys Leu Arg Thr Met Leu Gly Phe Thr Trp 
    290                 295                 300                 
Gln Met Gly Asp Tyr Pro Arg Gly Asn Ile Pro Pro Ala Gly Ser Leu 
305                 310                 315                 320 
Ile Phe Glu Arg Trp Arg Asn Gln Gln Ser Gly Gln Arg Val Val Arg 
                325                 330                 335     
Ile Tyr Phe Gln Ala Gln Ser Leu Asp Gln Ile Arg Gly Leu Ala Ala 
            340                 345                 350         
Leu Asp Asp Ser His Pro Pro Leu Arg Ser Glu Phe Ser Met Pro Asp 
        355                 360                 365             
Cys Gln Lys Thr Asp Ile Gly Thr Leu Cys Pro Tyr Asp Ala Val Met 
    370                 375                 380                 
Lys Arg Leu Asn Asp Ala Val Asp Arg Thr Ala Leu Leu Pro Val His 
385                 390                 395                 400 
Tyr Thr Pro His His His His His His 
                405                 

<210> 38
<211> 409
<212> PRT
<213> Artificial Sequence


<220> 
<223> Variant of wt sequence (Seq2)

<400> 38
Asp Thr Pro Ser Ser Gly Trp Thr Leu Glu Lys Val Val Glu Val Ser 
1               5                   10                  15      
Arg His Gly Val Arg Pro Pro Thr Glu Ser Asn Val Lys Thr Ile Gln 
            20                  25                  30          
Glu Gly Thr Asp Arg Gln Trp Pro Thr Trp Leu Thr Gln Tyr Gly Glu 
        35                  40                  45              
Leu Thr Gly His Gly Tyr Ala Ala Ala Glu Leu Lys Gly His Tyr Glu 
    50                  55                  60                  
Gly Gln Tyr Leu Arg Gln His Gly Leu Leu Cys Gln Ala Cys Pro Ala 
65                  70                  75                  80  
Pro Gly Asp Val Phe Val Trp Ala Ser Pro Leu Gln Arg Thr Arg Glu 
                85                  90                  95      
Thr Ala Met Ala Leu Met Asp Gly Val Phe Pro Gly Cys Gly Val Gly 
            100                 105                 110         
Ile Gln Gly Pro Glu Asp Glu Asp Asn Asp Pro Leu Phe His Ala Glu 
        115                 120                 125             
Thr Ala Gly Val Thr Leu Asp Gln Gln Gln Val Lys Ala Asp Leu Gln 
    130                 135                 140                 
Asn Ala Met Gln Asn Lys Ser Ala Ala Gln Ile Gln Ala Gln Trp Gln 
145                 150                 155                 160 
Pro Ala Ile Asp Arg Leu Lys Gln Ala Val Cys Leu Pro Asp Lys Pro 
                165                 170                 175     
Cys Pro Ala Phe Ser Thr Pro Trp Glu Val Lys Glu Asp Asn Asn Gly 
            180                 185                 190         
Ser Ile Arg Leu His Gly Pro Glu Val Leu Ala Ile Ile Ala Glu Thr 
        195                 200                 205             
Ile Gln Met Ser Tyr Ser Asn Asn Asn Pro Leu Ser Glu Val Ala Phe 
    210                 215                 220                 
Gly His Ala Lys Thr Ala Ala Glu Val Ala Ala Leu Met Pro Leu Leu 
225                 230                 235                 240 
Thr Ala Asn Tyr Asp Phe Thr Asn Asp Leu Pro Tyr Val Ala Arg Arg 
                245                 250                 255     
Gly Ala Ser Val Leu Met Asn Gln Ile Ala Leu Ala Leu Asn Thr Glu 
            260                 265                 270         
His Gln Ala Asp Ala Pro Pro Asp Ala Lys Trp Leu Leu Tyr Val Ala 
        275                 280                 285             
His Asp Thr Asn Ile Ala Lys Leu Arg Thr Met Leu Gly Phe Thr Trp 
    290                 295                 300                 
Gln Met Gly Asp Tyr Pro Arg Gly Asn Ile Pro Pro Ala Gly Ser Leu 
305                 310                 315                 320 
Ile Phe Glu Arg Trp Arg Asn Gln Gln Ser Gly Gln Arg Val Val Arg 
                325                 330                 335     
Ile Tyr Phe Gln Ala Gln Ser Leu Asp Gln Ile Arg Gly Leu Ala Ala 
            340                 345                 350         
Leu Asp Asp Ser His Pro Pro Leu Arg Ser Glu Phe Ser Met Pro Asp 
        355                 360                 365             
Cys Gln Lys Thr Asp Ile Gly Thr Leu Cys Pro Tyr Asp Ala Val Met 
    370                 375                 380                 
Lys Arg Leu Asn Asp Ala Val Asp Arg Thr Ala Leu Leu Pro Val His 
385                 390                 395                 400 
Tyr Thr Pro His His His His His His 
                405                 

<210> 39
<211> 409
<212> PRT
<213> Artificial Sequence


<220> 
<223> Variant of wt sequence (Seq2)

<400> 39
Asp Thr Pro Ser Ser Gly Trp Thr Leu Glu Lys Val Val Glu Val Ser 
1               5                   10                  15      
Arg His Gly Val Arg Pro Pro Thr Ala Ser Asn Val Ala Lys Ile Gln 
            20                  25                  30          
Glu Gly Thr Asp Arg Gln Trp Pro Thr Trp Leu Thr Gln Tyr Gly Glu 
        35                  40                  45              
Leu Thr Gly His Gly Tyr Ala Ala Ala Val Leu Lys Gly His Tyr Glu 
    50                  55                  60                  
Gly Gln Tyr Leu Arg Gln His Gly Leu Leu Cys Gln Ala Cys Pro Ala 
65                  70                  75                  80  
Pro Gly Asp Val Phe Val Trp Ala Ser Pro Leu Gln Arg Thr Arg Glu 
                85                  90                  95      
Thr Ala Met Ala Leu Met Asp Gly Val Phe Pro Gly Cys Gly Val Ala 
            100                 105                 110         
Ile Gln Gly Pro Glu Asp Glu Asp Asn Asp Pro Leu Phe His Ala Glu 
        115                 120                 125             
Thr Ala Gly Val Thr Leu Asp Gln Gln Gln Val Lys Ala Asp Leu Gln 
    130                 135                 140                 
Asn Ala Met Gln Asn Lys Ser Ala Ala Gln Ile Gln Ala Gln Trp Gln 
145                 150                 155                 160 
Pro Ala Ile Asp Arg Leu Lys Gln Ala Val Cys Leu Pro Asp Lys Pro 
                165                 170                 175     
Cys Pro Ala Phe Ser Thr Pro Trp Glu Val Lys Glu Asp Asn Asn Gly 
            180                 185                 190         
Ser Ile Thr Leu His Gly Pro Glu Val Leu Ala Ile Ile Ala Glu Thr 
        195                 200                 205             
Ile Gln Met Ser Tyr Ser Asn Asn Asn Pro Leu Ser Glu Val Ala Phe 
    210                 215                 220                 
Gly His Ala Lys Thr Ala Ala Glu Val Ala Ala Leu Met Pro Leu Leu 
225                 230                 235                 240 
Thr Ala Asn Tyr Asp Phe Thr Lys Asp Leu Pro Tyr Val Ala Arg Arg 
                245                 250                 255     
Gly Ala Ser Val Leu Met Asn Gln Ile Ala Leu Ala Leu Asn Thr Glu 
            260                 265                 270         
His Gln Ala Asp Ala Pro Pro Asp Ala Lys Trp Leu Leu Tyr Val Ala 
        275                 280                 285             
His Asp Thr Asn Ile Ala Met Leu Arg Thr Met Leu Gly Phe Thr Trp 
    290                 295                 300                 
Gln Met Gly Asp Tyr Pro Arg Gly Asn Ile Pro Pro Ala Gly Ser Leu 
305                 310                 315                 320 
Ile Phe Glu Arg Trp Arg Asn Gln Gln Ser Gly Gln Arg Val Val Arg 
                325                 330                 335     
Ile Tyr Phe Gln Ala Gln Ser Leu Asp Gln Ile Arg Gly Leu Ala Ala 
            340                 345                 350         
Leu Asp Asp Ser His Pro Pro Leu Arg Ser Glu Phe Ser Met Pro Asp 
        355                 360                 365             
Cys Gln Lys Thr Asp Ile Gly Thr Leu Cys Pro Tyr Asp Ala Val Met 
    370                 375                 380                 
Lys Arg Leu Asn Asp Ala Val Asp Arg Thr Ala Leu Leu Pro Val Arg 
385                 390                 395                 400 
Tyr Thr Pro His His His His His His 
                405                 

<210> 40
<211> 409
<212> PRT
<213> Artificial Sequence


<220> 
<223> Variant of wt sequence (Seq2)

<400> 40
Asp Thr Pro Ser Ser Gly Trp Thr Leu Glu Lys Val Val Glu Val Ser 
1               5                   10                  15      
Arg His Gly Val Arg Pro Pro Thr Ala Ser Asn Val Ala Lys Ile Gln 
            20                  25                  30          
Glu Gly Thr Asp Arg Gln Trp Pro Thr Trp Leu Thr Gln Tyr Gly Glu 
        35                  40                  45              
Leu Thr Gly His Gly Tyr Ala Ala Ala Val Leu Lys Gly His Tyr Glu 
    50                  55                  60                  
Gly Gln Tyr Leu Arg Gln His Gly Leu Leu Cys Gln Ala Cys Pro Ala 
65                  70                  75                  80  
Pro Gly Asp Val Phe Val Trp Ala Ser Pro Leu Gln Arg Thr Arg Glu 
                85                  90                  95      
Thr Ala Met Ala Leu Met Asp Gly Val Phe Pro Gly Cys Gly Val Ala 
            100                 105                 110         
Ile Gln Gly Pro Glu Asp Glu Asp Asn Asp Pro Leu Phe His Ala Glu 
        115                 120                 125             
Thr Ala Gly Val Thr Leu Asp Gln Gln Gln Val Lys Ala Asp Leu Gln 
    130                 135                 140                 
Asn Ala Met Gln Asn Lys Ser Ala Ala Gln Ile Gln Ala Gln Trp Gln 
145                 150                 155                 160 
Pro Ala Ile Asp Arg Leu Lys Gln Ala Val Cys Leu Pro Asp Lys Pro 
                165                 170                 175     
Cys Pro Ala Phe Ser Thr Pro Trp Glu Val Glu Glu Asp Asn Asn Gly 
            180                 185                 190         
Ser Ile Ser Leu His Gly Pro Glu Val Leu Ala Ile Ile Ala Glu Thr 
        195                 200                 205             
Ile Gln Met Ser Tyr Ser Asn Asn Asn Pro Leu Ser Glu Val Ala Phe 
    210                 215                 220                 
Gly His Ala Lys Thr Ala Ala Glu Val Ala Ala Leu Met Pro Leu Leu 
225                 230                 235                 240 
Thr Ala Asn Tyr Asp Phe Thr Lys Asp Leu Pro Tyr Val Ala Arg Arg 
                245                 250                 255     
Gly Ala Ser Val Leu Met Asn Gln Ile Ala Leu Ala Leu Asn Thr Glu 
            260                 265                 270         
His Gln Ala Asp Ala Pro Pro Asp Ala Lys Trp Leu Leu Tyr Val Ala 
        275                 280                 285             
His Asp Thr Asn Ile Ala Met Leu Arg Thr Met Leu Gly Phe Thr Trp 
    290                 295                 300                 
Gln Met Gly Asp Tyr Pro Arg Gly Asn Ile Pro Pro Ala Gly Ser Leu 
305                 310                 315                 320 
Ile Phe Glu Arg Trp Arg Asn Gln Gln Ser Gly Gln Arg Val Val Arg 
                325                 330                 335     
Ile Tyr Phe Gln Ala Gln Ser Leu Asp Gln Ile Arg Gly Leu Ala Ala 
            340                 345                 350         
Leu Asp Asp Ser His Pro Pro Leu Arg Ser Glu Phe Ser Met Pro Asp 
        355                 360                 365             
Cys Gln Lys Thr Asp Ile Gly Thr Leu Cys Pro Tyr Asp Ala Val Met 
    370                 375                 380                 
Lys Arg Leu Asn Asp Ala Val Asp Arg Thr Ala Leu Leu Pro Val His 
385                 390                 395                 400 
Tyr Thr Pro His His His His His His 
                405                 

<210> 41
<211> 409
<212> PRT
<213> Artificial Sequence


<220> 
<223> Variant of wt sequence (Seq2)

<400> 41
Glu Thr Thr Ser Ser Gly Trp Thr Leu Glu Lys Val Val Glu Val Ser 
1               5                   10                  15      
Arg His Gly Val Arg Pro Pro Thr Ala Ser Asn Val Ala Lys Ile Gln 
            20                  25                  30          
Glu Gly Thr Asp Arg Gln Trp Pro Thr Trp Leu Thr Gln Tyr Gly Glu 
        35                  40                  45              
Leu Thr Gly His Gly Tyr Ala Ala Ala Val Leu Lys Gly His Tyr Glu 
    50                  55                  60                  
Gly Gln Tyr Leu Arg Gln His Gly Leu Leu Cys Gln Ala Cys Pro Ala 
65                  70                  75                  80  
Pro Gly Asp Val Phe Val Trp Ala Ser Pro Leu Gln Arg Thr Arg Glu 
                85                  90                  95      
Thr Ala Met Ala Leu Met Asp Gly Val Phe Pro Gly Cys Gly Val Ala 
            100                 105                 110         
Ile Gln Gly Pro Glu Asp Glu Asp Asn Asp Pro Leu Phe His Ala Glu 
        115                 120                 125             
Thr Ala Gly Val Thr Leu Asp Gln Gln Gln Val Lys Ala Asp Leu Gln 
    130                 135                 140                 
Asn Ala Met Gln Asn Lys Ser Ala Ala Gln Ile Gln Ala Gln Trp Gln 
145                 150                 155                 160 
Pro Ala Ile Asp Arg Leu Lys Gln Ala Val Cys Leu Pro Asp Lys Pro 
                165                 170                 175     
Cys Pro Ala Phe Ser Thr Pro Trp Glu Val Lys Glu Asp Asn Asn Gly 
            180                 185                 190         
Ser Ile Thr Leu His Gly Pro Glu Val Leu Ala Asn Ile Ala Glu Thr 
        195                 200                 205             
Ile Gln Met Ser Tyr Ser Asn Asp Asn Pro Leu Ser Glu Val Ala Phe 
    210                 215                 220                 
Gly His Ala Lys Thr Ala Ala Glu Val Ala Ala Leu Met Pro Leu Leu 
225                 230                 235                 240 
Thr Ala Lys Tyr Asp Phe Thr Asn Asp Leu Pro Tyr Val Ala Arg Arg 
                245                 250                 255     
Gly Ala Ser Val Leu Met Asn Gln Ile Ala Leu Ala Leu Asn Thr Glu 
            260                 265                 270         
His Gln Ala Asp Ala Pro Pro Asp Ala Lys Trp Leu Leu Tyr Val Ala 
        275                 280                 285             
His Asp Thr Asn Ile Ala Met Leu Arg Thr Met Leu Gly Phe Thr Trp 
    290                 295                 300                 
Gln Met Gly Asp Tyr Pro Arg Gly Asn Ile Pro Pro Ala Gly Ser Leu 
305                 310                 315                 320 
Ile Phe Glu Arg Trp Arg Asn Gln Gln Ser Gly Gln Arg Val Val Arg 
                325                 330                 335     
Ile Tyr Phe Gln Ala Gln Ser Leu Asp Gln Ile Arg Gly Leu Ala Ala 
            340                 345                 350         
Leu Asp Asp Ser His Pro Pro Leu Arg Ser Glu Phe Ser Met Pro Asp 
        355                 360                 365             
Cys Gln Lys Thr Asp Ile Gly Thr Leu Cys Pro Tyr Asp Ala Val Met 
    370                 375                 380                 
Lys Arg Leu Asn Asp Ala Val Asp Arg Thr Ala Leu Leu Pro Val Arg 
385                 390                 395                 400 
Tyr Thr Pro His His His His His His 
                405                 

<210> 42
<211> 409
<212> PRT
<213> Artificial Sequence


<220> 
<223> Variant of wt sequence (Seq2)

<400> 42
Asp Thr Pro Ser Ser Gly Trp Thr Leu Glu Lys Val Val Glu Val Ser 
1               5                   10                  15      
Arg His Gly Val Arg Pro Pro Thr Glu Ser Asn Val Lys Thr Ile Gln 
            20                  25                  30          
Glu Gly Thr Asp Arg Gln Trp Pro Thr Trp Leu Thr Gln Tyr Gly Glu 
        35                  40                  45              
Leu Thr Gly His Gly Tyr Ala Ala Ala Glu Leu Lys Gly His Tyr Glu 
    50                  55                  60                  
Gly Gln Tyr Leu Arg Gln His Gly Leu Leu Cys Gln Ala Cys Pro Ala 
65                  70                  75                  80  
Pro Gly Asp Val Phe Val Trp Ala Ser Pro Leu Gln Arg Thr Arg Glu 
                85                  90                  95      
Thr Ala Met Ala Leu Met Asp Gly Val Phe Pro Gly Cys Gly Val Ala 
            100                 105                 110         
Ile Gln Gly Pro Glu Asp Glu Asp Asn Asp Pro Leu Phe His Ala Glu 
        115                 120                 125             
Thr Ala Gly Val Thr Leu Asp Gln Gln Gln Val Lys Ala Asp Leu Gln 
    130                 135                 140                 
Asn Ala Met Gln Asn Lys Ser Ala Ala Gln Ile Gln Ala Gln Trp Gln 
145                 150                 155                 160 
Pro Ala Ile Asp Arg Leu Lys Gln Ala Val Cys Leu Pro Asp Lys Pro 
                165                 170                 175     
Cys Pro Ala Phe Ser Thr Pro Trp Glu Val Lys Glu Asp Asn Asn Gly 
            180                 185                 190         
Ser Ile Arg Leu His Gly Pro Glu Val Leu Ala Ile Ile Ala Glu Thr 
        195                 200                 205             
Ile Gln Met Ser Tyr Ala Asn Asn Asn Pro Leu Ser Glu Val Ala Phe 
    210                 215                 220                 
Gly His Ala Lys Thr Ala Ala Glu Val Ala Ala Leu Met Pro Leu Leu 
225                 230                 235                 240 
Thr Ala Asn Tyr Asp Phe Thr Asn Asp Leu Pro Tyr Val Ala Arg Arg 
                245                 250                 255     
Gly Ala Ser Val Leu Met Asn Gln Ile Ala Leu Ala Leu Asn Thr Glu 
            260                 265                 270         
His Gln Ala Asp Ala Pro Pro Asp Ala Lys Trp Leu Leu Tyr Val Ala 
        275                 280                 285             
His Asp Thr Asn Ile Ala Lys Leu Arg Thr Met Leu Gly Phe Thr Trp 
    290                 295                 300                 
Gln Met Gly Asp Tyr Pro Arg Gly Asn Ile Pro Pro Ala Gly Ser Leu 
305                 310                 315                 320 
Ile Phe Glu Arg Trp Arg Asn Gln Gln Ser Gly Gln Arg Val Val Arg 
                325                 330                 335     
Ile Tyr Phe Gln Ala Gln Ser Leu Asp Gln Ile Arg Gly Leu Ala Ala 
            340                 345                 350         
Leu Asp Asp Ser His Pro Pro Leu Arg Ser Glu Phe Ser Met Pro Asp 
        355                 360                 365             
Cys Gln Lys Thr Asp Ile Gly Thr Leu Cys Pro Tyr Asp Ala Val Met 
    370                 375                 380                 
Lys Arg Leu Asn Asp Ala Val Asp Arg Thr Ala Leu Leu Pro Val His 
385                 390                 395                 400 
Tyr Thr Pro His His His His His His 
                405                 

<210> 43
<211> 409
<212> PRT
<213> Artificial Sequence


<220> 
<223> Variant of wt sequence (Seq2)

<400> 43
Asp Thr Pro Ser Ser Gly Trp Thr Leu Glu Lys Val Val Glu Val Ser 
1               5                   10                  15      
Arg His Gly Val Arg Pro Pro Thr Glu Gly Asn Val Lys Ala Ile Gln 
            20                  25                  30          
Glu Gly Thr Asp Arg Gln Trp Pro Thr Trp Leu Thr Gln Tyr Gly Glu 
        35                  40                  45              
Leu Thr Gly His Gly Tyr Ala Ala Ala Glu Leu Lys Gly His Tyr Glu 
    50                  55                  60                  
Gly Gln Tyr Leu Arg Gln His Gly Leu Leu Cys Gln Ala Cys Pro Ala 
65                  70                  75                  80  
Pro Gly Asp Val Phe Val Trp Ala Ser Pro Leu Gln Arg Thr Arg Glu 
                85                  90                  95      
Thr Ala Met Ala Leu Met Asp Gly Val Phe Pro Gly Cys Gly Val Ala 
            100                 105                 110         
Ile Gln Gly Pro Glu Asp Glu Asp Asn Asp Pro Leu Phe His Ala Glu 
        115                 120                 125             
Thr Ala Gly Val Thr Leu Asp Gln Gln Gln Val Lys Ala Asp Leu Gln 
    130                 135                 140                 
Asn Ala Met Gln Asn Lys Ser Ala Ala Gln Ile Gln Ala Gln Trp Gln 
145                 150                 155                 160 
Pro Ala Ile Asp Arg Leu Lys Gln Ala Val Cys Leu Pro Asp Lys Pro 
                165                 170                 175     
Cys Pro Ala Phe Ser Thr Pro Trp Glu Val Lys Glu Asp Asn Asn Gly 
            180                 185                 190         
Ser Ile Arg Leu His Gly Pro Glu Val Leu Ala Ile Ile Ala Glu Thr 
        195                 200                 205             
Ile Gln Met Ser Tyr Ser Asn Asn Asn Pro Leu Ser Glu Val Ala Phe 
    210                 215                 220                 
Gly His Ala Lys Thr Ala Ala Glu Val Ala Ala Leu Met Pro Leu Leu 
225                 230                 235                 240 
Thr Ala Asn Tyr Asp Phe Thr Lys Asp Leu Pro Tyr Val Ala Arg Arg 
                245                 250                 255     
Gly Ala Ser Val Leu Met Asn Gln Ile Ala Leu Ala Leu Asn Thr Glu 
            260                 265                 270         
His Gln Ala Asp Ala Pro Pro Asp Ala Lys Trp Leu Leu Tyr Val Ala 
        275                 280                 285             
His Asp Thr Asn Ile Ala Lys Leu Arg Thr Met Leu Gly Phe Thr Trp 
    290                 295                 300                 
Gln Met Gly Asp Tyr Pro Arg Gly Asn Ile Pro Pro Ala Gly Ser Leu 
305                 310                 315                 320 
Ile Phe Glu Arg Trp Arg Asn Gln Gln Ser Gly Asp Arg Val Val Arg 
                325                 330                 335     
Ile Tyr Phe Gln Ala Gln Ser Leu Asp Gln Ile Arg Gly Leu Ala Ala 
            340                 345                 350         
Leu Asp Asp Ser His Pro Pro Leu Arg Ser Glu Phe Ser Met Pro Asp 
        355                 360                 365             
Cys Gln Lys Thr Asp Ile Gly Thr Leu Cys Pro Tyr Asp Ala Val Met 
    370                 375                 380                 
Lys Arg Leu Asn Asp Ala Val Asp Arg Thr Ala Leu Leu Pro Val His 
385                 390                 395                 400 
Tyr Thr Pro His His His His His His 
                405                 

<210> 44
<211> 409
<212> PRT
<213> Artificial Sequence


<220> 
<223> Variant of wt sequence (Seq2)

<400> 44
Asp Thr Pro Ser Ser Gly Trp Thr Leu Glu Lys Val Val Glu Val Ser 
1               5                   10                  15      
Arg His Gly Val Arg Pro Pro Thr Glu Ser Asn Val Lys Thr Ile Gln 
            20                  25                  30          
Glu Gly Thr Asp Arg Gln Trp Pro Thr Trp Leu Thr Gln Tyr Gly Glu 
        35                  40                  45              
Leu Thr Gly His Gly Tyr Ala Ala Ala Glu Leu Lys Gly His Tyr Glu 
    50                  55                  60                  
Gly Gln Tyr Leu Arg Gln His Gly Leu Leu Cys Gln Ala Cys Pro Ala 
65                  70                  75                  80  
Pro Gly Asp Val Phe Val Trp Ala Ser Pro Leu Gln Arg Thr Arg Glu 
                85                  90                  95      
Thr Ala Met Ala Leu Met Asp Gly Val Phe Pro Gly Cys Gly Val Ala 
            100                 105                 110         
Ile Gln Gly Pro Glu Asp Glu Asp Asn Asp Pro Leu Phe His Ala Glu 
        115                 120                 125             
Thr Ala Gly Val Thr Leu Asp Gln Gln Gln Val Lys Ala Asp Leu Gln 
    130                 135                 140                 
Asn Ala Met Gln Asn Lys Ser Ala Ala Gln Ile Gln Ala Gln Trp Gln 
145                 150                 155                 160 
Pro Ala Ile Asp Arg Leu Lys Gln Ala Val Cys Leu Pro Asp Lys Pro 
                165                 170                 175     
Cys Pro Ala Phe Ser Thr Pro Trp Glu Val Lys Glu Asp Asn Asn Gly 
            180                 185                 190         
Ser Ile Arg Leu His Gly Pro Glu Val Leu Ala Ile Ile Ala Glu Thr 
        195                 200                 205             
Ile Arg Met Ser Tyr Ser Asn Asn Asn Pro Leu Ser Glu Val Ala Phe 
    210                 215                 220                 
Gly His Ala Lys Thr Ala Ala Glu Val Ala Ala Leu Met Pro Leu Leu 
225                 230                 235                 240 
Thr Ala Asn Tyr Asp Phe Thr Asn Asp Leu Pro Tyr Val Ala Arg Arg 
                245                 250                 255     
Gly Ala Ser Val Leu Met Asn Gln Ile Ala Leu Ala Leu Asn Thr Glu 
            260                 265                 270         
His Gln Ala Asp Ala Pro Pro Asp Ala Lys Trp Leu Leu Tyr Val Ala 
        275                 280                 285             
His Asp Thr Asn Ile Ala Lys Leu Arg Thr Met Leu Gly Phe Thr Trp 
    290                 295                 300                 
Gln Met Gly Asp Tyr Pro Arg Gly Asn Ile Pro Pro Ala Gly Ser Leu 
305                 310                 315                 320 
Ile Phe Glu Arg Trp Arg Asn Gln Gln Ser Gly Gln Arg Val Val Arg 
                325                 330                 335     
Ile Tyr Phe Gln Ala Gln Ser Leu Asp Gln Ile Arg Gly Leu Ala Ala 
            340                 345                 350         
Leu Asp Asp Ser His Pro Pro Leu Arg Ser Glu Phe Ser Met Pro Asp 
        355                 360                 365             
Cys Gln Lys Thr Asp Ile Gly Thr Leu Cys Pro Tyr Asp Ala Val Met 
    370                 375                 380                 
Lys Arg Leu Asn Asp Ala Val Asp Arg Thr Ala Leu Leu Pro Val His 
385                 390                 395                 400 
Tyr Thr Pro His His His His His His 
                405                 

<210> 45
<211> 414
<212> PRT
<213> Artificial Sequence


<220> 
<223> Variant of wt sequence (Seq2)

<400> 45
Asp Thr Pro Ser Ala Ala Ala Pro Ser Ser Gly Trp Thr Leu Glu Lys 
1               5                   10                  15      
Val Val Glu Val Ser Arg His Gly Val Arg Pro Pro Thr Glu Ser Asn 
            20                  25                  30          
Val Lys Thr Ile Gln Glu Gly Thr Asp Arg Gln Trp Pro Thr Trp Leu 
        35                  40                  45              
Thr Gln Tyr Gly Glu Leu Thr Gly His Gly Tyr Ala Ala Ala Glu Leu 
    50                  55                  60                  
Lys Gly His Tyr Glu Gly Gln Tyr Leu Arg Gln His Gly Leu Leu Cys 
65                  70                  75                  80  
Gln Ala Cys Pro Ala Pro Gly Asp Val Phe Val Trp Ala Ser Pro Leu 
                85                  90                  95      
Gln Arg Thr Arg Glu Thr Ala Met Ala Leu Met Asp Gly Val Phe Pro 
            100                 105                 110         
Gly Cys Gly Val Ala Ile Gln Gly Pro Glu Asp Glu Asp Asn Asp Pro 
        115                 120                 125             
Leu Phe His Ala Glu Thr Ala Gly Val Thr Leu Asp Gln Gln Gln Val 
    130                 135                 140                 
Lys Ala Asp Leu Gln Asn Ala Met Gln Asn Lys Ser Ala Ala Gln Ile 
145                 150                 155                 160 
Gln Ala Gln Trp Gln Pro Ala Ile Asp Arg Leu Lys Gln Ala Val Cys 
                165                 170                 175     
Leu Pro Asp Lys Pro Cys Pro Ala Phe Ser Thr Pro Trp Glu Val Lys 
            180                 185                 190         
Glu Asp Asn Asn Gly Ser Ile Arg Leu His Gly Pro Glu Val Leu Ala 
        195                 200                 205             
Ile Ile Ala Glu Thr Ile Gln Met Ser Tyr Ser Asn Asn Asn Pro Leu 
    210                 215                 220                 
Ser Glu Val Ala Phe Gly His Ala Lys Thr Ala Ala Glu Val Ala Ala 
225                 230                 235                 240 
Leu Met Pro Leu Leu Thr Ala Asn Tyr Asp Phe Thr Asn Asp Leu Pro 
                245                 250                 255     
Tyr Val Ala Arg Arg Gly Ala Ser Val Leu Met Asn Gln Ile Ala Leu 
            260                 265                 270         
Ala Leu Asn Thr Glu His Gln Ala Asp Ala Pro Pro Asp Ala Lys Trp 
        275                 280                 285             
Leu Leu Tyr Val Ala His Asp Thr Asn Ile Ala Lys Leu Arg Thr Met 
    290                 295                 300                 
Leu Gly Phe Thr Trp Gln Met Gly Asp Tyr Pro Arg Gly Asn Ile Pro 
305                 310                 315                 320 
Pro Ala Gly Ser Leu Ile Phe Glu Arg Trp Arg Asn Gln Gln Ser Gly 
                325                 330                 335     
Gln Arg Val Val Arg Ile Tyr Phe Gln Ala Gln Ser Leu Asp Gln Ile 
            340                 345                 350         
Arg Gly Leu Ala Ala Leu Asp Asp Ser His Pro Pro Leu Arg Ser Glu 
        355                 360                 365             
Phe Ser Met Pro Asp Cys Gln Lys Thr Asp Ile Gly Thr Leu Cys Pro 
    370                 375                 380                 
Tyr Asp Ala Val Met Lys Arg Leu Asn Asp Ala Val Asp Arg Thr Ala 
385                 390                 395                 400 
Leu Leu Pro Val His Tyr Thr Pro His His His His His His 
                405                 410                 

<210> 46
<211> 414
<212> PRT
<213> Artificial Sequence


<220> 
<223> Variant of wt sequence (Seq2)

<400> 46
Asp Thr Pro Ser Ser Gly Trp Thr Leu Glu Lys Val Val Glu Val Ser 
1               5                   10                  15      
Arg His Gly Val Arg Pro Pro Thr Glu Ser Asn Val Lys Thr Ile Gln 
            20                  25                  30          
Glu Gly Thr Asp Arg Gln Trp Pro Thr Trp Leu Thr Gln Tyr Gly Glu 
        35                  40                  45              
Leu Thr Gly His Gly Tyr Ala Ala Ala Glu Leu Lys Gly His Tyr Glu 
    50                  55                  60                  
Gly Gln Tyr Leu Arg Gln His Gly Leu Leu Cys Gln Ala Cys Pro Ala 
65                  70                  75                  80  
Pro Gly Asp Val Phe Val Trp Ala Ser Pro Leu Gln Arg Thr Arg Glu 
                85                  90                  95      
Thr Ala Met Ala Leu Met Asp Gly Val Phe Pro Gly Cys Gly Val Ala 
            100                 105                 110         
Ile Gln Gly Pro Glu Asp Glu Asp Asn Asp Pro Leu Phe His Ala Glu 
        115                 120                 125             
Thr Ala Gly Val Thr Leu Asp Gln Gln Gln Val Lys Ala Asp Leu Gln 
    130                 135                 140                 
Asn Ala Met Gln Asn Lys Ser Ala Ala Gln Ile Gln Ala Gln Trp Gln 
145                 150                 155                 160 
Pro Ala Ile Asp Arg Leu Lys Gln Ala Val Cys Leu Pro Asp Lys Pro 
                165                 170                 175     
Cys Pro Ala Phe Ser Thr Pro Trp Glu Val Lys Glu Asp Asn Asn Gly 
            180                 185                 190         
Ser Ile Arg Leu His Gly Pro Glu Val Leu Ala Ile Ile Ala Glu Thr 
        195                 200                 205             
Ile Gln Met Ser Tyr Ser Asn Asn Asn Pro Leu Ser Glu Val Ala Phe 
    210                 215                 220                 
Gly His Ala Lys Thr Ala Ala Glu Val Ala Ala Leu Met Pro Leu Leu 
225                 230                 235                 240 
Thr Ala Asn Tyr Asp Phe Thr Asn Asp Leu Pro Tyr Val Ala Arg Arg 
                245                 250                 255     
Gly Ala Ser Val Leu Met Asn Gln Ile Ala Leu Ala Leu Asn Thr Glu 
            260                 265                 270         
His Gln Ala Ala Ala Ala Gln Ala Asp Ala Pro Pro Asp Ala Lys Trp 
        275                 280                 285             
Leu Leu Tyr Val Ala His Asp Thr Asn Ile Ala Lys Leu Arg Thr Met 
    290                 295                 300                 
Leu Gly Phe Thr Trp Gln Met Gly Asp Tyr Pro Arg Gly Asn Ile Pro 
305                 310                 315                 320 
Pro Ala Gly Ser Leu Ile Phe Glu Arg Trp Arg Asn Gln Gln Ser Gly 
                325                 330                 335     
Gln Arg Val Val Arg Ile Tyr Phe Gln Ala Gln Ser Leu Asp Gln Ile 
            340                 345                 350         
Arg Gly Leu Ala Ala Leu Asp Asp Ser His Pro Pro Leu Arg Ser Glu 
        355                 360                 365             
Phe Ser Met Pro Asp Cys Gln Lys Thr Asp Ile Gly Thr Leu Cys Pro 
    370                 375                 380                 
Tyr Asp Ala Val Met Lys Arg Leu Asn Asp Ala Val Asp Arg Thr Ala 
385                 390                 395                 400 
Leu Leu Pro Val His Tyr Thr Pro His His His His His His 
                405                 410                 

<210> 47
<211> 414
<212> PRT
<213> Artificial Sequence


<220> 
<223> Variant of wt sequence (Seq2)

<400> 47
Asp Thr Pro Ser Ser Gly Trp Thr Leu Glu Lys Val Val Glu Val Ser 
1               5                   10                  15      
Arg His Gly Val Arg Pro Pro Thr Glu Ser Asn Val Lys Thr Ile Gln 
            20                  25                  30          
Glu Gly Thr Asp Arg Gln Trp Pro Thr Trp Leu Thr Gln Tyr Gly Glu 
        35                  40                  45              
Leu Thr Gly His Gly Tyr Ala Ala Ala Glu Leu Lys Gly His Tyr Glu 
    50                  55                  60                  
Gly Gln Tyr Leu Arg Gln His Gly Leu Leu Cys Gln Ala Cys Pro Ala 
65                  70                  75                  80  
Pro Gly Asp Val Phe Val Trp Ala Ser Pro Leu Gln Arg Thr Arg Glu 
                85                  90                  95      
Thr Ala Met Ala Leu Met Asp Gly Val Phe Pro Gly Cys Gly Val Ala 
            100                 105                 110         
Ile Gln Gly Pro Glu Asp Glu Asp Asn Asp Pro Leu Phe His Ala Glu 
        115                 120                 125             
Thr Ala Gly Val Thr Leu Asp Gln Gln Gln Val Lys Ala Asp Leu Gln 
    130                 135                 140                 
Asn Ala Met Gln Asn Lys Ser Ala Ala Gln Ile Gln Ala Gln Trp Gln 
145                 150                 155                 160 
Pro Ala Ile Asp Arg Leu Lys Gln Ala Val Cys Leu Pro Asp Lys Pro 
                165                 170                 175     
Cys Pro Ala Phe Ser Thr Pro Trp Glu Val Lys Glu Asp Asn Asn Gly 
            180                 185                 190         
Ser Ile Arg Leu His Gly Pro Glu Val Ala Ala Ala Glu Val Leu Ala 
        195                 200                 205             
Ile Ile Ala Glu Thr Ile Gln Met Ser Tyr Ser Asn Asn Asn Pro Leu 
    210                 215                 220                 
Ser Glu Val Ala Phe Gly His Ala Lys Thr Ala Ala Glu Val Ala Ala 
225                 230                 235                 240 
Leu Met Pro Leu Leu Thr Ala Asn Tyr Asp Phe Thr Asn Asp Leu Pro 
                245                 250                 255     
Tyr Val Ala Arg Arg Gly Ala Ser Val Leu Met Asn Gln Ile Ala Leu 
            260                 265                 270         
Ala Leu Asn Thr Glu His Gln Ala Asp Ala Pro Pro Asp Ala Lys Trp 
        275                 280                 285             
Leu Leu Tyr Val Ala His Asp Thr Asn Ile Ala Lys Leu Arg Thr Met 
    290                 295                 300                 
Leu Gly Phe Thr Trp Gln Met Gly Asp Tyr Pro Arg Gly Asn Ile Pro 
305                 310                 315                 320 
Pro Ala Gly Ser Leu Ile Phe Glu Arg Trp Arg Asn Gln Gln Ser Gly 
                325                 330                 335     
Gln Arg Val Val Arg Ile Tyr Phe Gln Ala Gln Ser Leu Asp Gln Ile 
            340                 345                 350         
Arg Gly Leu Ala Ala Leu Asp Asp Ser His Pro Pro Leu Arg Ser Glu 
        355                 360                 365             
Phe Ser Met Pro Asp Cys Gln Lys Thr Asp Ile Gly Thr Leu Cys Pro 
    370                 375                 380                 
Tyr Asp Ala Val Met Lys Arg Leu Asn Asp Ala Val Asp Arg Thr Ala 
385                 390                 395                 400 
Leu Leu Pro Val His Tyr Thr Pro His His His His His His 
                405                 410                 

