                         SEQUENCE LISTING

<110>  DA VOLTERRA
 
<120>  COMPOSITIONS FOR THE TREATMENT OF GRAFT VERSUS HOST DISEASE

<130>  B2812PC00

<160>  90    

<170>  PatentIn version 3.5

<210>  1
<211>  240
<212>  PRT
<213>  artificial

<220>
<223>  VIM-2

<400>  1

Val Asp Ser Ser Gly Glu Tyr Pro Thr Val Ser Glu Ile Pro Val Gly 
1               5                   10                  15      


Glu Val Arg Leu Tyr Gln Ile Ala Asp Gly Val Trp Ser His Ile Ala 
            20                  25                  30          


Thr Gln Ser Phe Asp Gly Ala Val Tyr Pro Ser Asn Gly Leu Ile Val 
        35                  40                  45              


Arg Asp Gly Asp Glu Leu Leu Leu Ile Asp Thr Ala Trp Gly Ala Lys 
    50                  55                  60                  


Asn Thr Ala Ala Leu Leu Ala Glu Ile Glu Lys Gln Ile Gly Leu Pro 
65                  70                  75                  80  


Val Thr Arg Ala Val Ser Thr His Phe His Asp Asp Arg Val Gly Gly 
                85                  90                  95      


Val Asp Val Leu Arg Ala Ala Gly Val Ala Thr Tyr Ala Ser Pro Ser 
            100                 105                 110         


Thr Arg Arg Leu Ala Glu Val Glu Gly Asn Glu Ile Pro Thr His Ser 
        115                 120                 125             


Leu Glu Gly Leu Ser Ser Ser Gly Asp Ala Val Arg Phe Gly Pro Val 
    130                 135                 140                 


Glu Leu Phe Tyr Pro Gly Ala Ala His Ser Thr Asp Asn Leu Val Val 
145                 150                 155                 160 


Tyr Val Pro Ser Ala Ser Val Leu Tyr Gly Gly Cys Ala Ile Tyr Glu 
                165                 170                 175     


Leu Ser Arg Thr Ser Ala Gly Asn Val Ala Asp Ala Asp Leu Ala Glu 
            180                 185                 190         


Trp Pro Thr Ser Ile Glu Arg Ile Gln Gln His Tyr Pro Glu Ala Gln 
        195                 200                 205             


Phe Val Ile Pro Gly His Gly Leu Pro Gly Gly Leu Asp Leu Leu Lys 
    210                 215                 220                 


His Thr Thr Asn Val Val Lys Ala His Thr Asn Arg Ser Val Val Glu 
225                 230                 235                 240 


<210>  2
<211>  235
<212>  PRT
<213>  artificial

<220>
<223>  VIM-2 variant

<400>  2

Met Asp Ser Ser Gly Glu Tyr Pro Thr Val Ser Glu Ile Pro Val Gly 
1               5                   10                  15      


Glu Val Arg Leu Tyr Gln Ile Ala Asp Gly Val Trp Ser His Ile Ala 
            20                  25                  30          


Thr Gln Ser Phe Asp Gly Ala Val Tyr Pro Ser Asn Gly Leu Ile Val 
        35                  40                  45              


Arg Asp Gly Asp Glu Leu Leu Leu Ile Asp Thr Ala Trp Gly Ala Lys 
    50                  55                  60                  


Asn Thr Ala Ala Leu Leu Ala Glu Ile Glu Lys Gln Ile Gly Leu Pro 
65                  70                  75                  80  


Val Thr Arg Ala Val Ser Thr His Phe His Asp Asp Arg Val Gly Gly 
                85                  90                  95      


Val Asp Val Leu Arg Ala Ala Gly Val Ala Thr Tyr Ala Ser Pro Ser 
            100                 105                 110         


Thr Arg Arg Leu Ala Glu Val Glu Gly Asn Glu Ile Pro Thr His Ser 
        115                 120                 125             


Leu Glu Gly Leu Ser Ser Ser Gly Asp Ala Val Arg Phe Gly Pro Val 
    130                 135                 140                 


Glu Leu Phe Tyr Pro Gly Ala Ala His Ser Thr Asp Asn Leu Val Val 
145                 150                 155                 160 


Tyr Val Pro Ser Ala Ser Val Leu Tyr Gly Gly Cys Ala Ile Tyr Glu 
                165                 170                 175     


Leu Ser Arg Thr Ser Ala Gly Asn Val Ala Asp Ala Asp Leu Ala Glu 
            180                 185                 190         


Trp Pro Thr Ser Ile Glu Arg Ile Gln Gln His Tyr Pro Glu Ala Gln 
        195                 200                 205             


Phe Val Ile Pro Gly His Gly Leu Pro Gly Gly Leu Asp Leu Leu Lys 
    210                 215                 220                 


His Thr Thr Asn Val Val Lys Ala His Thr Asn 
225                 230                 235 


<210>  3
<211>  235
<212>  PRT
<213>  artificial

<220>
<223>  VIM-2 variant

<400>  3

Met Asp Ser Ser Gly Glu Tyr Pro Thr Val Ser Glu Ile Pro Val Gly 
1               5                   10                  15      


Glu Val Arg Leu Tyr Gln Ile Ala Asp Gly Val Trp Ser His Ile Ala 
            20                  25                  30          


Thr Arg Ser Phe Asp Gly Ala Val Tyr Pro Ser Asn Gly Leu Ile Val 
        35                  40                  45              


Arg Asp Gly Asp Glu Leu Leu Leu Ile Asp Thr Ala Trp Gly Ala Lys 
    50                  55                  60                  


Asn Thr Ala Ala Leu Leu Ala Glu Ile Glu Lys Gln Ile Gly Leu Pro 
65                  70                  75                  80  


Val Thr Arg Ala Val Ser Thr His Phe His Asp Asp Arg Val Gly Gly 
                85                  90                  95      


Val Asp Val Leu Arg Ala Ala Gly Val Ala Thr Tyr Ala Ser Pro Ser 
            100                 105                 110         


Thr Arg Arg Leu Ala Glu Val Glu Gly Asn Glu Ile Pro Thr His Ser 
        115                 120                 125             


Leu Glu Gly Leu Ser Ser Ser Gly Asp Ala Val Arg Phe Gly Pro Val 
    130                 135                 140                 


Glu Leu Phe Tyr Pro Gly Ala Ala His Ser Thr Asp Asn Leu Val Val 
145                 150                 155                 160 


Tyr Val Pro Ser Ala Ser Val Leu Tyr Gly Gly Cys Ala Ile Tyr Glu 
                165                 170                 175     


Leu Ser Arg Thr Ser Ala Gly Asn Val Ala Asp Ala Asp Leu Ala Glu 
            180                 185                 190         


Trp Pro Thr Ser Ile Glu Arg Ile Gln Gln His Tyr Pro Glu Ala Gln 
        195                 200                 205             


Phe Val Ile Pro Gly His Gly Leu Pro Gly Gly Leu Asp Leu Leu Lys 
    210                 215                 220                 


His Thr Thr Asn Val Val Lys Ala His Thr Asn 
225                 230                 235 


<210>  4
<211>  235
<212>  PRT
<213>  artificial

<220>
<223>  VIM-2 variant

<400>  4

Val Asp Ser Ser Gly Glu Tyr Pro Thr Val Ser Glu Ile Pro Val Gly 
1               5                   10                  15      


Glu Val Arg Leu Tyr Gln Ile Ala Asp Gly Val Trp Ser His Ile Ala 
            20                  25                  30          


Thr Gln Ser Phe Asp Gly Ala Val Tyr Pro Ser Asn Gly Leu Ile Val 
        35                  40                  45              


Arg Asp Gly Asp Glu Leu Leu Leu Ile Asp Thr Ala Trp Gly Ala Lys 
    50                  55                  60                  


Asn Thr Ala Ala Leu Leu Ala Glu Ile Glu Lys Gln Ile Gly Leu Pro 
65                  70                  75                  80  


Val Thr Arg Ala Val Ser Thr His Phe His Asp Asp Arg Val Gly Gly 
                85                  90                  95      


Val Asp Val Leu Arg Ala Ala Gly Val Ala Thr Tyr Ala Ser Pro Ser 
            100                 105                 110         


Thr Arg Arg Leu Ala Glu Val Glu Gly Asn Glu Ile Pro Thr His Ser 
        115                 120                 125             


Leu Glu Gly Leu Ser Ser Ser Gly Asp Ala Val Arg Phe Gly Pro Val 
    130                 135                 140                 


Glu Leu Phe Tyr Pro Gly Ala Ala His Ser Thr Asp Asn Leu Val Val 
145                 150                 155                 160 


Tyr Val Pro Ser Ala Ser Val Leu Tyr Gly Gly Cys Ala Ile Tyr Glu 
                165                 170                 175     


Leu Ser Arg Thr Ser Ala Gly Asn Val Ala Asp Ala Asp Leu Ala Glu 
            180                 185                 190         


Trp Pro Thr Ser Ile Glu Arg Ile Gln Gln His Tyr Pro Glu Ala Gln 
        195                 200                 205             


Phe Val Ile Pro Gly His Gly Leu Pro Gly Gly Leu Asp Leu Leu Lys 
    210                 215                 220                 


His Thr Thr Asn Val Val Lys Ala His Thr Asn 
225                 230                 235 


<210>  5
<211>  235
<212>  PRT
<213>  artificial

<220>
<223>  VIM-2 variant

<400>  5

Val Asp Ser Ser Gly Glu Tyr Pro Thr Val Ser Glu Ile Pro Val Gly 
1               5                   10                  15      


Glu Val Arg Leu Tyr Gln Ile Ala Asp Gly Val Trp Ser His Ile Ala 
            20                  25                  30          


Thr Arg Ser Phe Asp Gly Ala Val Tyr Pro Ser Asn Gly Leu Ile Val 
        35                  40                  45              


Arg Asp Gly Asp Glu Leu Leu Leu Ile Asp Thr Ala Trp Gly Ala Lys 
    50                  55                  60                  


Asn Thr Ala Ala Leu Leu Ala Glu Ile Glu Lys Gln Ile Gly Leu Pro 
65                  70                  75                  80  


Val Thr Arg Ala Val Ser Thr His Phe His Asp Asp Arg Val Gly Gly 
                85                  90                  95      


Val Asp Val Leu Arg Ala Ala Gly Val Ala Thr Tyr Ala Ser Pro Ser 
            100                 105                 110         


Thr Arg Arg Leu Ala Glu Val Glu Gly Asn Glu Ile Pro Thr His Ser 
        115                 120                 125             


Leu Glu Gly Leu Ser Ser Ser Gly Asp Ala Val Arg Phe Gly Pro Val 
    130                 135                 140                 


Glu Leu Phe Tyr Pro Gly Ala Ala His Ser Thr Asp Asn Leu Val Val 
145                 150                 155                 160 


Tyr Val Pro Ser Ala Ser Val Leu Tyr Gly Gly Cys Ala Ile Tyr Glu 
                165                 170                 175     


Leu Ser Arg Thr Ser Ala Gly Asn Val Ala Asp Ala Asp Leu Ala Glu 
            180                 185                 190         


Trp Pro Thr Ser Ile Glu Arg Ile Gln Gln His Tyr Pro Glu Ala Gln 
        195                 200                 205             


Phe Val Ile Pro Gly His Gly Leu Pro Gly Gly Leu Asp Leu Leu Lys 
    210                 215                 220                 


His Thr Thr Asn Val Val Lys Ala His Thr Asn 
225                 230                 235 


<210>  6
<211>  240
<212>  PRT
<213>  artificial

<220>
<223>  VIM-2  Q34R Q22H

<400>  6

Val Asp Ser Ser Gly Glu Tyr Pro Thr Val Ser Glu Ile Pro Val Gly 
1               5                   10                  15      


Glu Val Arg Leu Tyr His Ile Ala Asp Gly Val Trp Ser His Ile Ala 
            20                  25                  30          


Thr Arg Ser Phe Asp Gly Ala Val Tyr Pro Ser Asn Gly Leu Ile Val 
        35                  40                  45              


Arg Asp Gly Asp Glu Leu Leu Leu Ile Asp Thr Ala Trp Gly Ala Lys 
    50                  55                  60                  


Asn Thr Ala Ala Leu Leu Ala Glu Ile Glu Lys Gln Ile Gly Leu Pro 
65                  70                  75                  80  


Val Thr Arg Ala Val Ser Thr His Phe His Asp Asp Arg Val Gly Gly 
                85                  90                  95      


Val Asp Val Leu Arg Ala Ala Gly Val Ala Thr Tyr Ala Ser Pro Ser 
            100                 105                 110         


Thr Arg Arg Leu Ala Glu Val Glu Gly Asn Glu Ile Pro Thr His Ser 
        115                 120                 125             


Leu Glu Gly Leu Ser Ser Ser Gly Asp Ala Val Arg Phe Gly Pro Val 
    130                 135                 140                 


Glu Leu Phe Tyr Pro Gly Ala Ala His Ser Thr Asp Asn Leu Val Val 
145                 150                 155                 160 


Tyr Val Pro Ser Ala Ser Val Leu Tyr Gly Gly Cys Ala Ile Tyr Glu 
                165                 170                 175     


Leu Ser Arg Thr Ser Ala Gly Asn Val Ala Asp Ala Asp Leu Ala Glu 
            180                 185                 190         


Trp Pro Thr Ser Ile Glu Arg Ile Gln Gln His Tyr Pro Glu Ala Gln 
        195                 200                 205             


Phe Val Ile Pro Gly His Gly Leu Pro Gly Gly Leu Asp Leu Leu Lys 
    210                 215                 220                 


His Thr Thr Asn Val Val Lys Ala His Thr Asn Arg Ser Val Val Glu 
225                 230                 235                 240 


<210>  7
<211>  240
<212>  PRT
<213>  artificial

<220>
<223>  VIM-2  Q34R Q22N

<400>  7

Val Asp Ser Ser Gly Glu Tyr Pro Thr Val Ser Glu Ile Pro Val Gly 
1               5                   10                  15      


Glu Val Arg Leu Tyr Asn Ile Ala Asp Gly Val Trp Ser His Ile Ala 
            20                  25                  30          


Thr Arg Ser Phe Asp Gly Ala Val Tyr Pro Ser Asn Gly Leu Ile Val 
        35                  40                  45              


Arg Asp Gly Asp Glu Leu Leu Leu Ile Asp Thr Ala Trp Gly Ala Lys 
    50                  55                  60                  


Asn Thr Ala Ala Leu Leu Ala Glu Ile Glu Lys Gln Ile Gly Leu Pro 
65                  70                  75                  80  


Val Thr Arg Ala Val Ser Thr His Phe His Asp Asp Arg Val Gly Gly 
                85                  90                  95      


Val Asp Val Leu Arg Ala Ala Gly Val Ala Thr Tyr Ala Ser Pro Ser 
            100                 105                 110         


Thr Arg Arg Leu Ala Glu Val Glu Gly Asn Glu Ile Pro Thr His Ser 
        115                 120                 125             


Leu Glu Gly Leu Ser Ser Ser Gly Asp Ala Val Arg Phe Gly Pro Val 
    130                 135                 140                 


Glu Leu Phe Tyr Pro Gly Ala Ala His Ser Thr Asp Asn Leu Val Val 
145                 150                 155                 160 


Tyr Val Pro Ser Ala Ser Val Leu Tyr Gly Gly Cys Ala Ile Tyr Glu 
                165                 170                 175     


Leu Ser Arg Thr Ser Ala Gly Asn Val Ala Asp Ala Asp Leu Ala Glu 
            180                 185                 190         


Trp Pro Thr Ser Ile Glu Arg Ile Gln Gln His Tyr Pro Glu Ala Gln 
        195                 200                 205             


Phe Val Ile Pro Gly His Gly Leu Pro Gly Gly Leu Asp Leu Leu Lys 
    210                 215                 220                 


His Thr Thr Asn Val Val Lys Ala His Thr Asn Arg Ser Val Val Glu 
225                 230                 235                 240 


<210>  8
<211>  240
<212>  PRT
<213>  artificial

<220>
<223>  VIM-2  Q34R E130D

<400>  8

Val Asp Ser Ser Gly Glu Tyr Pro Thr Val Ser Glu Ile Pro Val Gly 
1               5                   10                  15      


Glu Val Arg Leu Tyr Gln Ile Ala Asp Gly Val Trp Ser His Ile Ala 
            20                  25                  30          


Thr Arg Ser Phe Asp Gly Ala Val Tyr Pro Ser Asn Gly Leu Ile Val 
        35                  40                  45              


Arg Asp Gly Asp Glu Leu Leu Leu Ile Asp Thr Ala Trp Gly Ala Lys 
    50                  55                  60                  


Asn Thr Ala Ala Leu Leu Ala Glu Ile Glu Lys Gln Ile Gly Leu Pro 
65                  70                  75                  80  


Val Thr Arg Ala Val Ser Thr His Phe His Asp Asp Arg Val Gly Gly 
                85                  90                  95      


Val Asp Val Leu Arg Ala Ala Gly Val Ala Thr Tyr Ala Ser Pro Ser 
            100                 105                 110         


Thr Arg Arg Leu Ala Glu Val Glu Gly Asn Glu Ile Pro Thr His Ser 
        115                 120                 125             


Leu Asp Gly Leu Ser Ser Ser Gly Asp Ala Val Arg Phe Gly Pro Val 
    130                 135                 140                 


Glu Leu Phe Tyr Pro Gly Ala Ala His Ser Thr Asp Asn Leu Val Val 
145                 150                 155                 160 


Tyr Val Pro Ser Ala Ser Val Leu Tyr Gly Gly Cys Ala Ile Tyr Glu 
                165                 170                 175     


Leu Ser Arg Thr Ser Ala Gly Asn Val Ala Asp Ala Asp Leu Ala Glu 
            180                 185                 190         


Trp Pro Thr Ser Ile Glu Arg Ile Gln Gln His Tyr Pro Glu Ala Gln 
        195                 200                 205             


Phe Val Ile Pro Gly His Gly Leu Pro Gly Gly Leu Asp Leu Leu Lys 
    210                 215                 220                 


His Thr Thr Asn Val Val Lys Ala His Thr Asn Arg Ser Val Val Glu 
225                 230                 235                 240 


<210>  9
<211>  240
<212>  PRT
<213>  artificial

<220>
<223>  VIM-2  Q34R E130D Q22N

<400>  9

Val Asp Ser Ser Gly Glu Tyr Pro Thr Val Ser Glu Ile Pro Val Gly 
1               5                   10                  15      


Glu Val Arg Leu Tyr Asn Ile Ala Asp Gly Val Trp Ser His Ile Ala 
            20                  25                  30          


Thr Arg Ser Phe Asp Gly Ala Val Tyr Pro Ser Asn Gly Leu Ile Val 
        35                  40                  45              


Arg Asp Gly Asp Glu Leu Leu Leu Ile Asp Thr Ala Trp Gly Ala Lys 
    50                  55                  60                  


Asn Thr Ala Ala Leu Leu Ala Glu Ile Glu Lys Gln Ile Gly Leu Pro 
65                  70                  75                  80  


Val Thr Arg Ala Val Ser Thr His Phe His Asp Asp Arg Val Gly Gly 
                85                  90                  95      


Val Asp Val Leu Arg Ala Ala Gly Val Ala Thr Tyr Ala Ser Pro Ser 
            100                 105                 110         


Thr Arg Arg Leu Ala Glu Val Glu Gly Asn Glu Ile Pro Thr His Ser 
        115                 120                 125             


Leu Asp Gly Leu Ser Ser Ser Gly Asp Ala Val Arg Phe Gly Pro Val 
    130                 135                 140                 


Glu Leu Phe Tyr Pro Gly Ala Ala His Ser Thr Asp Asn Leu Val Val 
145                 150                 155                 160 


Tyr Val Pro Ser Ala Ser Val Leu Tyr Gly Gly Cys Ala Ile Tyr Glu 
                165                 170                 175     


Leu Ser Arg Thr Ser Ala Gly Asn Val Ala Asp Ala Asp Leu Ala Glu 
            180                 185                 190         


Trp Pro Thr Ser Ile Glu Arg Ile Gln Gln His Tyr Pro Glu Ala Gln 
        195                 200                 205             


Phe Val Ile Pro Gly His Gly Leu Pro Gly Gly Leu Asp Leu Leu Lys 
    210                 215                 220                 


His Thr Thr Asn Val Val Lys Ala His Thr Asn Arg Ser Val Val Glu 
225                 230                 235                 240 


<210>  10
<211>  240
<212>  PRT
<213>  artificial

<220>
<223>  VIM-2  Q34R E130D Q22H

<400>  10

Val Asp Ser Ser Gly Glu Tyr Pro Thr Val Ser Glu Ile Pro Val Gly 
1               5                   10                  15      


Glu Val Arg Leu Tyr His Ile Ala Asp Gly Val Trp Ser His Ile Ala 
            20                  25                  30          


Thr Arg Ser Phe Asp Gly Ala Val Tyr Pro Ser Asn Gly Leu Ile Val 
        35                  40                  45              


Arg Asp Gly Asp Glu Leu Leu Leu Ile Asp Thr Ala Trp Gly Ala Lys 
    50                  55                  60                  


Asn Thr Ala Ala Leu Leu Ala Glu Ile Glu Lys Gln Ile Gly Leu Pro 
65                  70                  75                  80  


Val Thr Arg Ala Val Ser Thr His Phe His Asp Asp Arg Val Gly Gly 
                85                  90                  95      


Val Asp Val Leu Arg Ala Ala Gly Val Ala Thr Tyr Ala Ser Pro Ser 
            100                 105                 110         


Thr Arg Arg Leu Ala Glu Val Glu Gly Asn Glu Ile Pro Thr His Ser 
        115                 120                 125             


Leu Asp Gly Leu Ser Ser Ser Gly Asp Ala Val Arg Phe Gly Pro Val 
    130                 135                 140                 


Glu Leu Phe Tyr Pro Gly Ala Ala His Ser Thr Asp Asn Leu Val Val 
145                 150                 155                 160 


Tyr Val Pro Ser Ala Ser Val Leu Tyr Gly Gly Cys Ala Ile Tyr Glu 
                165                 170                 175     


Leu Ser Arg Thr Ser Ala Gly Asn Val Ala Asp Ala Asp Leu Ala Glu 
            180                 185                 190         


Trp Pro Thr Ser Ile Glu Arg Ile Gln Gln His Tyr Pro Glu Ala Gln 
        195                 200                 205             


Phe Val Ile Pro Gly His Gly Leu Pro Gly Gly Leu Asp Leu Leu Lys 
    210                 215                 220                 


His Thr Thr Asn Val Val Lys Ala His Thr Asn Arg Ser Val Val Glu 
225                 230                 235                 240 


<210>  11
<211>  235
<212>  PRT
<213>  artificial

<220>
<223>  VIM-2  Q34R Q22H DCT236

<400>  11

Val Asp Ser Ser Gly Glu Tyr Pro Thr Val Ser Glu Ile Pro Val Gly 
1               5                   10                  15      


Glu Val Arg Leu Tyr His Ile Ala Asp Gly Val Trp Ser His Ile Ala 
            20                  25                  30          


Thr Arg Ser Phe Asp Gly Ala Val Tyr Pro Ser Asn Gly Leu Ile Val 
        35                  40                  45              


Arg Asp Gly Asp Glu Leu Leu Leu Ile Asp Thr Ala Trp Gly Ala Lys 
    50                  55                  60                  


Asn Thr Ala Ala Leu Leu Ala Glu Ile Glu Lys Gln Ile Gly Leu Pro 
65                  70                  75                  80  


Val Thr Arg Ala Val Ser Thr His Phe His Asp Asp Arg Val Gly Gly 
                85                  90                  95      


Val Asp Val Leu Arg Ala Ala Gly Val Ala Thr Tyr Ala Ser Pro Ser 
            100                 105                 110         


Thr Arg Arg Leu Ala Glu Val Glu Gly Asn Glu Ile Pro Thr His Ser 
        115                 120                 125             


Leu Glu Gly Leu Ser Ser Ser Gly Asp Ala Val Arg Phe Gly Pro Val 
    130                 135                 140                 


Glu Leu Phe Tyr Pro Gly Ala Ala His Ser Thr Asp Asn Leu Val Val 
145                 150                 155                 160 


Tyr Val Pro Ser Ala Ser Val Leu Tyr Gly Gly Cys Ala Ile Tyr Glu 
                165                 170                 175     


Leu Ser Arg Thr Ser Ala Gly Asn Val Ala Asp Ala Asp Leu Ala Glu 
            180                 185                 190         


Trp Pro Thr Ser Ile Glu Arg Ile Gln Gln His Tyr Pro Glu Ala Gln 
        195                 200                 205             


Phe Val Ile Pro Gly His Gly Leu Pro Gly Gly Leu Asp Leu Leu Lys 
    210                 215                 220                 


His Thr Thr Asn Val Val Lys Ala His Thr Asn 
225                 230                 235 


<210>  12
<211>  235
<212>  PRT
<213>  artificial

<220>
<223>  VIM-2  Q34R Q22N DCT236

<400>  12

Val Asp Ser Ser Gly Glu Tyr Pro Thr Val Ser Glu Ile Pro Val Gly 
1               5                   10                  15      


Glu Val Arg Leu Tyr Asn Ile Ala Asp Gly Val Trp Ser His Ile Ala 
            20                  25                  30          


Thr Arg Ser Phe Asp Gly Ala Val Tyr Pro Ser Asn Gly Leu Ile Val 
        35                  40                  45              


Arg Asp Gly Asp Glu Leu Leu Leu Ile Asp Thr Ala Trp Gly Ala Lys 
    50                  55                  60                  


Asn Thr Ala Ala Leu Leu Ala Glu Ile Glu Lys Gln Ile Gly Leu Pro 
65                  70                  75                  80  


Val Thr Arg Ala Val Ser Thr His Phe His Asp Asp Arg Val Gly Gly 
                85                  90                  95      


Val Asp Val Leu Arg Ala Ala Gly Val Ala Thr Tyr Ala Ser Pro Ser 
            100                 105                 110         


Thr Arg Arg Leu Ala Glu Val Glu Gly Asn Glu Ile Pro Thr His Ser 
        115                 120                 125             


Leu Glu Gly Leu Ser Ser Ser Gly Asp Ala Val Arg Phe Gly Pro Val 
    130                 135                 140                 


Glu Leu Phe Tyr Pro Gly Ala Ala His Ser Thr Asp Asn Leu Val Val 
145                 150                 155                 160 


Tyr Val Pro Ser Ala Ser Val Leu Tyr Gly Gly Cys Ala Ile Tyr Glu 
                165                 170                 175     


Leu Ser Arg Thr Ser Ala Gly Asn Val Ala Asp Ala Asp Leu Ala Glu 
            180                 185                 190         


Trp Pro Thr Ser Ile Glu Arg Ile Gln Gln His Tyr Pro Glu Ala Gln 
        195                 200                 205             


Phe Val Ile Pro Gly His Gly Leu Pro Gly Gly Leu Asp Leu Leu Lys 
    210                 215                 220                 


His Thr Thr Asn Val Val Lys Ala His Thr Asn 
225                 230                 235 


<210>  13
<211>  235
<212>  PRT
<213>  artificial

<220>
<223>  VIM-2  Q34R E130D DCT236

<400>  13

Val Asp Ser Ser Gly Glu Tyr Pro Thr Val Ser Glu Ile Pro Val Gly 
1               5                   10                  15      


Glu Val Arg Leu Tyr Gln Ile Ala Asp Gly Val Trp Ser His Ile Ala 
            20                  25                  30          


Thr Arg Ser Phe Asp Gly Ala Val Tyr Pro Ser Asn Gly Leu Ile Val 
        35                  40                  45              


Arg Asp Gly Asp Glu Leu Leu Leu Ile Asp Thr Ala Trp Gly Ala Lys 
    50                  55                  60                  


Asn Thr Ala Ala Leu Leu Ala Glu Ile Glu Lys Gln Ile Gly Leu Pro 
65                  70                  75                  80  


Val Thr Arg Ala Val Ser Thr His Phe His Asp Asp Arg Val Gly Gly 
                85                  90                  95      


Val Asp Val Leu Arg Ala Ala Gly Val Ala Thr Tyr Ala Ser Pro Ser 
            100                 105                 110         


Thr Arg Arg Leu Ala Glu Val Glu Gly Asn Glu Ile Pro Thr His Ser 
        115                 120                 125             


Leu Asp Gly Leu Ser Ser Ser Gly Asp Ala Val Arg Phe Gly Pro Val 
    130                 135                 140                 


Glu Leu Phe Tyr Pro Gly Ala Ala His Ser Thr Asp Asn Leu Val Val 
145                 150                 155                 160 


Tyr Val Pro Ser Ala Ser Val Leu Tyr Gly Gly Cys Ala Ile Tyr Glu 
                165                 170                 175     


Leu Ser Arg Thr Ser Ala Gly Asn Val Ala Asp Ala Asp Leu Ala Glu 
            180                 185                 190         


Trp Pro Thr Ser Ile Glu Arg Ile Gln Gln His Tyr Pro Glu Ala Gln 
        195                 200                 205             


Phe Val Ile Pro Gly His Gly Leu Pro Gly Gly Leu Asp Leu Leu Lys 
    210                 215                 220                 


His Thr Thr Asn Val Val Lys Ala His Thr Asn 
225                 230                 235 


<210>  14
<211>  235
<212>  PRT
<213>  artificial

<220>
<223>  VIM-2  Q34R E130D Q22N DCT236

<400>  14

Val Asp Ser Ser Gly Glu Tyr Pro Thr Val Ser Glu Ile Pro Val Gly 
1               5                   10                  15      


Glu Val Arg Leu Tyr Asn Ile Ala Asp Gly Val Trp Ser His Ile Ala 
            20                  25                  30          


Thr Arg Ser Phe Asp Gly Ala Val Tyr Pro Ser Asn Gly Leu Ile Val 
        35                  40                  45              


Arg Asp Gly Asp Glu Leu Leu Leu Ile Asp Thr Ala Trp Gly Ala Lys 
    50                  55                  60                  


Asn Thr Ala Ala Leu Leu Ala Glu Ile Glu Lys Gln Ile Gly Leu Pro 
65                  70                  75                  80  


Val Thr Arg Ala Val Ser Thr His Phe His Asp Asp Arg Val Gly Gly 
                85                  90                  95      


Val Asp Val Leu Arg Ala Ala Gly Val Ala Thr Tyr Ala Ser Pro Ser 
            100                 105                 110         


Thr Arg Arg Leu Ala Glu Val Glu Gly Asn Glu Ile Pro Thr His Ser 
        115                 120                 125             


Leu Asp Gly Leu Ser Ser Ser Gly Asp Ala Val Arg Phe Gly Pro Val 
    130                 135                 140                 


Glu Leu Phe Tyr Pro Gly Ala Ala His Ser Thr Asp Asn Leu Val Val 
145                 150                 155                 160 


Tyr Val Pro Ser Ala Ser Val Leu Tyr Gly Gly Cys Ala Ile Tyr Glu 
                165                 170                 175     


Leu Ser Arg Thr Ser Ala Gly Asn Val Ala Asp Ala Asp Leu Ala Glu 
            180                 185                 190         


Trp Pro Thr Ser Ile Glu Arg Ile Gln Gln His Tyr Pro Glu Ala Gln 
        195                 200                 205             


Phe Val Ile Pro Gly His Gly Leu Pro Gly Gly Leu Asp Leu Leu Lys 
    210                 215                 220                 


His Thr Thr Asn Val Val Lys Ala His Thr Asn 
225                 230                 235 


<210>  15
<211>  235
<212>  PRT
<213>  artificial

<220>
<223>  VIM-2  Q34R E130D Q22H DCT236

<400>  15

Val Asp Ser Ser Gly Glu Tyr Pro Thr Val Ser Glu Ile Pro Val Gly 
1               5                   10                  15      


Glu Val Arg Leu Tyr His Ile Ala Asp Gly Val Trp Ser His Ile Ala 
            20                  25                  30          


Thr Arg Ser Phe Asp Gly Ala Val Tyr Pro Ser Asn Gly Leu Ile Val 
        35                  40                  45              


Arg Asp Gly Asp Glu Leu Leu Leu Ile Asp Thr Ala Trp Gly Ala Lys 
    50                  55                  60                  


Asn Thr Ala Ala Leu Leu Ala Glu Ile Glu Lys Gln Ile Gly Leu Pro 
65                  70                  75                  80  


Val Thr Arg Ala Val Ser Thr His Phe His Asp Asp Arg Val Gly Gly 
                85                  90                  95      


Val Asp Val Leu Arg Ala Ala Gly Val Ala Thr Tyr Ala Ser Pro Ser 
            100                 105                 110         


Thr Arg Arg Leu Ala Glu Val Glu Gly Asn Glu Ile Pro Thr His Ser 
        115                 120                 125             


Leu Asp Gly Leu Ser Ser Ser Gly Asp Ala Val Arg Phe Gly Pro Val 
    130                 135                 140                 


Glu Leu Phe Tyr Pro Gly Ala Ala His Ser Thr Asp Asn Leu Val Val 
145                 150                 155                 160 


Tyr Val Pro Ser Ala Ser Val Leu Tyr Gly Gly Cys Ala Ile Tyr Glu 
                165                 170                 175     


Leu Ser Arg Thr Ser Ala Gly Asn Val Ala Asp Ala Asp Leu Ala Glu 
            180                 185                 190         


Trp Pro Thr Ser Ile Glu Arg Ile Gln Gln His Tyr Pro Glu Ala Gln 
        195                 200                 205             


Phe Val Ile Pro Gly His Gly Leu Pro Gly Gly Leu Asp Leu Leu Lys 
    210                 215                 220                 


His Thr Thr Asn Val Val Lys Ala His Thr Asn 
225                 230                 235 


<210>  16
<211>  240
<212>  PRT
<213>  artificial

<220>
<223>  VIM-2  V1M Q34R Q22H

<400>  16

Met Asp Ser Ser Gly Glu Tyr Pro Thr Val Ser Glu Ile Pro Val Gly 
1               5                   10                  15      


Glu Val Arg Leu Tyr His Ile Ala Asp Gly Val Trp Ser His Ile Ala 
            20                  25                  30          


Thr Arg Ser Phe Asp Gly Ala Val Tyr Pro Ser Asn Gly Leu Ile Val 
        35                  40                  45              


Arg Asp Gly Asp Glu Leu Leu Leu Ile Asp Thr Ala Trp Gly Ala Lys 
    50                  55                  60                  


Asn Thr Ala Ala Leu Leu Ala Glu Ile Glu Lys Gln Ile Gly Leu Pro 
65                  70                  75                  80  


Val Thr Arg Ala Val Ser Thr His Phe His Asp Asp Arg Val Gly Gly 
                85                  90                  95      


Val Asp Val Leu Arg Ala Ala Gly Val Ala Thr Tyr Ala Ser Pro Ser 
            100                 105                 110         


Thr Arg Arg Leu Ala Glu Val Glu Gly Asn Glu Ile Pro Thr His Ser 
        115                 120                 125             


Leu Glu Gly Leu Ser Ser Ser Gly Asp Ala Val Arg Phe Gly Pro Val 
    130                 135                 140                 


Glu Leu Phe Tyr Pro Gly Ala Ala His Ser Thr Asp Asn Leu Val Val 
145                 150                 155                 160 


Tyr Val Pro Ser Ala Ser Val Leu Tyr Gly Gly Cys Ala Ile Tyr Glu 
                165                 170                 175     


Leu Ser Arg Thr Ser Ala Gly Asn Val Ala Asp Ala Asp Leu Ala Glu 
            180                 185                 190         


Trp Pro Thr Ser Ile Glu Arg Ile Gln Gln His Tyr Pro Glu Ala Gln 
        195                 200                 205             


Phe Val Ile Pro Gly His Gly Leu Pro Gly Gly Leu Asp Leu Leu Lys 
    210                 215                 220                 


His Thr Thr Asn Val Val Lys Ala His Thr Asn Arg Ser Val Val Glu 
225                 230                 235                 240 


<210>  17
<211>  240
<212>  PRT
<213>  artificial

<220>
<223>  VIM-2  V1M Q34R Q22N

<400>  17

Met Asp Ser Ser Gly Glu Tyr Pro Thr Val Ser Glu Ile Pro Val Gly 
1               5                   10                  15      


Glu Val Arg Leu Tyr Asn Ile Ala Asp Gly Val Trp Ser His Ile Ala 
            20                  25                  30          


Thr Arg Ser Phe Asp Gly Ala Val Tyr Pro Ser Asn Gly Leu Ile Val 
        35                  40                  45              


Arg Asp Gly Asp Glu Leu Leu Leu Ile Asp Thr Ala Trp Gly Ala Lys 
    50                  55                  60                  


Asn Thr Ala Ala Leu Leu Ala Glu Ile Glu Lys Gln Ile Gly Leu Pro 
65                  70                  75                  80  


Val Thr Arg Ala Val Ser Thr His Phe His Asp Asp Arg Val Gly Gly 
                85                  90                  95      


Val Asp Val Leu Arg Ala Ala Gly Val Ala Thr Tyr Ala Ser Pro Ser 
            100                 105                 110         


Thr Arg Arg Leu Ala Glu Val Glu Gly Asn Glu Ile Pro Thr His Ser 
        115                 120                 125             


Leu Glu Gly Leu Ser Ser Ser Gly Asp Ala Val Arg Phe Gly Pro Val 
    130                 135                 140                 


Glu Leu Phe Tyr Pro Gly Ala Ala His Ser Thr Asp Asn Leu Val Val 
145                 150                 155                 160 


Tyr Val Pro Ser Ala Ser Val Leu Tyr Gly Gly Cys Ala Ile Tyr Glu 
                165                 170                 175     


Leu Ser Arg Thr Ser Ala Gly Asn Val Ala Asp Ala Asp Leu Ala Glu 
            180                 185                 190         


Trp Pro Thr Ser Ile Glu Arg Ile Gln Gln His Tyr Pro Glu Ala Gln 
        195                 200                 205             


Phe Val Ile Pro Gly His Gly Leu Pro Gly Gly Leu Asp Leu Leu Lys 
    210                 215                 220                 


His Thr Thr Asn Val Val Lys Ala His Thr Asn Arg Ser Val Val Glu 
225                 230                 235                 240 


<210>  18
<211>  240
<212>  PRT
<213>  artificial

<220>
<223>  VIM-2  V1M Q34R E130D

<400>  18

Met Asp Ser Ser Gly Glu Tyr Pro Thr Val Ser Glu Ile Pro Val Gly 
1               5                   10                  15      


Glu Val Arg Leu Tyr Gln Ile Ala Asp Gly Val Trp Ser His Ile Ala 
            20                  25                  30          


Thr Arg Ser Phe Asp Gly Ala Val Tyr Pro Ser Asn Gly Leu Ile Val 
        35                  40                  45              


Arg Asp Gly Asp Glu Leu Leu Leu Ile Asp Thr Ala Trp Gly Ala Lys 
    50                  55                  60                  


Asn Thr Ala Ala Leu Leu Ala Glu Ile Glu Lys Gln Ile Gly Leu Pro 
65                  70                  75                  80  


Val Thr Arg Ala Val Ser Thr His Phe His Asp Asp Arg Val Gly Gly 
                85                  90                  95      


Val Asp Val Leu Arg Ala Ala Gly Val Ala Thr Tyr Ala Ser Pro Ser 
            100                 105                 110         


Thr Arg Arg Leu Ala Glu Val Glu Gly Asn Glu Ile Pro Thr His Ser 
        115                 120                 125             


Leu Asp Gly Leu Ser Ser Ser Gly Asp Ala Val Arg Phe Gly Pro Val 
    130                 135                 140                 


Glu Leu Phe Tyr Pro Gly Ala Ala His Ser Thr Asp Asn Leu Val Val 
145                 150                 155                 160 


Tyr Val Pro Ser Ala Ser Val Leu Tyr Gly Gly Cys Ala Ile Tyr Glu 
                165                 170                 175     


Leu Ser Arg Thr Ser Ala Gly Asn Val Ala Asp Ala Asp Leu Ala Glu 
            180                 185                 190         


Trp Pro Thr Ser Ile Glu Arg Ile Gln Gln His Tyr Pro Glu Ala Gln 
        195                 200                 205             


Phe Val Ile Pro Gly His Gly Leu Pro Gly Gly Leu Asp Leu Leu Lys 
    210                 215                 220                 


His Thr Thr Asn Val Val Lys Ala His Thr Asn Arg Ser Val Val Glu 
225                 230                 235                 240 


<210>  19
<211>  240
<212>  PRT
<213>  artificial

<220>
<223>  VIM-2  V1M Q34R E130D Q22N

<400>  19

Met Asp Ser Ser Gly Glu Tyr Pro Thr Val Ser Glu Ile Pro Val Gly 
1               5                   10                  15      


Glu Val Arg Leu Tyr Asn Ile Ala Asp Gly Val Trp Ser His Ile Ala 
            20                  25                  30          


Thr Arg Ser Phe Asp Gly Ala Val Tyr Pro Ser Asn Gly Leu Ile Val 
        35                  40                  45              


Arg Asp Gly Asp Glu Leu Leu Leu Ile Asp Thr Ala Trp Gly Ala Lys 
    50                  55                  60                  


Asn Thr Ala Ala Leu Leu Ala Glu Ile Glu Lys Gln Ile Gly Leu Pro 
65                  70                  75                  80  


Val Thr Arg Ala Val Ser Thr His Phe His Asp Asp Arg Val Gly Gly 
                85                  90                  95      


Val Asp Val Leu Arg Ala Ala Gly Val Ala Thr Tyr Ala Ser Pro Ser 
            100                 105                 110         


Thr Arg Arg Leu Ala Glu Val Glu Gly Asn Glu Ile Pro Thr His Ser 
        115                 120                 125             


Leu Asp Gly Leu Ser Ser Ser Gly Asp Ala Val Arg Phe Gly Pro Val 
    130                 135                 140                 


Glu Leu Phe Tyr Pro Gly Ala Ala His Ser Thr Asp Asn Leu Val Val 
145                 150                 155                 160 


Tyr Val Pro Ser Ala Ser Val Leu Tyr Gly Gly Cys Ala Ile Tyr Glu 
                165                 170                 175     


Leu Ser Arg Thr Ser Ala Gly Asn Val Ala Asp Ala Asp Leu Ala Glu 
            180                 185                 190         


Trp Pro Thr Ser Ile Glu Arg Ile Gln Gln His Tyr Pro Glu Ala Gln 
        195                 200                 205             


Phe Val Ile Pro Gly His Gly Leu Pro Gly Gly Leu Asp Leu Leu Lys 
    210                 215                 220                 


His Thr Thr Asn Val Val Lys Ala His Thr Asn Arg Ser Val Val Glu 
225                 230                 235                 240 


<210>  20
<211>  240
<212>  PRT
<213>  artificial

<220>
<223>  VIM-2  V1M Q34R E130D Q22H

<400>  20

Met Asp Ser Ser Gly Glu Tyr Pro Thr Val Ser Glu Ile Pro Val Gly 
1               5                   10                  15      


Glu Val Arg Leu Tyr His Ile Ala Asp Gly Val Trp Ser His Ile Ala 
            20                  25                  30          


Thr Arg Ser Phe Asp Gly Ala Val Tyr Pro Ser Asn Gly Leu Ile Val 
        35                  40                  45              


Arg Asp Gly Asp Glu Leu Leu Leu Ile Asp Thr Ala Trp Gly Ala Lys 
    50                  55                  60                  


Asn Thr Ala Ala Leu Leu Ala Glu Ile Glu Lys Gln Ile Gly Leu Pro 
65                  70                  75                  80  


Val Thr Arg Ala Val Ser Thr His Phe His Asp Asp Arg Val Gly Gly 
                85                  90                  95      


Val Asp Val Leu Arg Ala Ala Gly Val Ala Thr Tyr Ala Ser Pro Ser 
            100                 105                 110         


Thr Arg Arg Leu Ala Glu Val Glu Gly Asn Glu Ile Pro Thr His Ser 
        115                 120                 125             


Leu Asp Gly Leu Ser Ser Ser Gly Asp Ala Val Arg Phe Gly Pro Val 
    130                 135                 140                 


Glu Leu Phe Tyr Pro Gly Ala Ala His Ser Thr Asp Asn Leu Val Val 
145                 150                 155                 160 


Tyr Val Pro Ser Ala Ser Val Leu Tyr Gly Gly Cys Ala Ile Tyr Glu 
                165                 170                 175     


Leu Ser Arg Thr Ser Ala Gly Asn Val Ala Asp Ala Asp Leu Ala Glu 
            180                 185                 190         


Trp Pro Thr Ser Ile Glu Arg Ile Gln Gln His Tyr Pro Glu Ala Gln 
        195                 200                 205             


Phe Val Ile Pro Gly His Gly Leu Pro Gly Gly Leu Asp Leu Leu Lys 
    210                 215                 220                 


His Thr Thr Asn Val Val Lys Ala His Thr Asn Arg Ser Val Val Glu 
225                 230                 235                 240 


<210>  21
<211>  235
<212>  PRT
<213>  artificial

<220>
<223>  VIM-2  V1M Q34R Q22H DCT236

<400>  21

Met Asp Ser Ser Gly Glu Tyr Pro Thr Val Ser Glu Ile Pro Val Gly 
1               5                   10                  15      


Glu Val Arg Leu Tyr His Ile Ala Asp Gly Val Trp Ser His Ile Ala 
            20                  25                  30          


Thr Arg Ser Phe Asp Gly Ala Val Tyr Pro Ser Asn Gly Leu Ile Val 
        35                  40                  45              


Arg Asp Gly Asp Glu Leu Leu Leu Ile Asp Thr Ala Trp Gly Ala Lys 
    50                  55                  60                  


Asn Thr Ala Ala Leu Leu Ala Glu Ile Glu Lys Gln Ile Gly Leu Pro 
65                  70                  75                  80  


Val Thr Arg Ala Val Ser Thr His Phe His Asp Asp Arg Val Gly Gly 
                85                  90                  95      


Val Asp Val Leu Arg Ala Ala Gly Val Ala Thr Tyr Ala Ser Pro Ser 
            100                 105                 110         


Thr Arg Arg Leu Ala Glu Val Glu Gly Asn Glu Ile Pro Thr His Ser 
        115                 120                 125             


Leu Glu Gly Leu Ser Ser Ser Gly Asp Ala Val Arg Phe Gly Pro Val 
    130                 135                 140                 


Glu Leu Phe Tyr Pro Gly Ala Ala His Ser Thr Asp Asn Leu Val Val 
145                 150                 155                 160 


Tyr Val Pro Ser Ala Ser Val Leu Tyr Gly Gly Cys Ala Ile Tyr Glu 
                165                 170                 175     


Leu Ser Arg Thr Ser Ala Gly Asn Val Ala Asp Ala Asp Leu Ala Glu 
            180                 185                 190         


Trp Pro Thr Ser Ile Glu Arg Ile Gln Gln His Tyr Pro Glu Ala Gln 
        195                 200                 205             


Phe Val Ile Pro Gly His Gly Leu Pro Gly Gly Leu Asp Leu Leu Lys 
    210                 215                 220                 


His Thr Thr Asn Val Val Lys Ala His Thr Asn 
225                 230                 235 


<210>  22
<211>  235
<212>  PRT
<213>  artificial

<220>
<223>  VIM-2  V1M Q34R Q22N DCT236

<400>  22

Met Asp Ser Ser Gly Glu Tyr Pro Thr Val Ser Glu Ile Pro Val Gly 
1               5                   10                  15      


Glu Val Arg Leu Tyr Asn Ile Ala Asp Gly Val Trp Ser His Ile Ala 
            20                  25                  30          


Thr Arg Ser Phe Asp Gly Ala Val Tyr Pro Ser Asn Gly Leu Ile Val 
        35                  40                  45              


Arg Asp Gly Asp Glu Leu Leu Leu Ile Asp Thr Ala Trp Gly Ala Lys 
    50                  55                  60                  


Asn Thr Ala Ala Leu Leu Ala Glu Ile Glu Lys Gln Ile Gly Leu Pro 
65                  70                  75                  80  


Val Thr Arg Ala Val Ser Thr His Phe His Asp Asp Arg Val Gly Gly 
                85                  90                  95      


Val Asp Val Leu Arg Ala Ala Gly Val Ala Thr Tyr Ala Ser Pro Ser 
            100                 105                 110         


Thr Arg Arg Leu Ala Glu Val Glu Gly Asn Glu Ile Pro Thr His Ser 
        115                 120                 125             


Leu Glu Gly Leu Ser Ser Ser Gly Asp Ala Val Arg Phe Gly Pro Val 
    130                 135                 140                 


Glu Leu Phe Tyr Pro Gly Ala Ala His Ser Thr Asp Asn Leu Val Val 
145                 150                 155                 160 


Tyr Val Pro Ser Ala Ser Val Leu Tyr Gly Gly Cys Ala Ile Tyr Glu 
                165                 170                 175     


Leu Ser Arg Thr Ser Ala Gly Asn Val Ala Asp Ala Asp Leu Ala Glu 
            180                 185                 190         


Trp Pro Thr Ser Ile Glu Arg Ile Gln Gln His Tyr Pro Glu Ala Gln 
        195                 200                 205             


Phe Val Ile Pro Gly His Gly Leu Pro Gly Gly Leu Asp Leu Leu Lys 
    210                 215                 220                 


His Thr Thr Asn Val Val Lys Ala His Thr Asn 
225                 230                 235 


<210>  23
<211>  235
<212>  PRT
<213>  artificial

<220>
<223>  VIM-2  V1M Q34R E130D DCT236

<400>  23

Met Asp Ser Ser Gly Glu Tyr Pro Thr Val Ser Glu Ile Pro Val Gly 
1               5                   10                  15      


Glu Val Arg Leu Tyr Gln Ile Ala Asp Gly Val Trp Ser His Ile Ala 
            20                  25                  30          


Thr Arg Ser Phe Asp Gly Ala Val Tyr Pro Ser Asn Gly Leu Ile Val 
        35                  40                  45              


Arg Asp Gly Asp Glu Leu Leu Leu Ile Asp Thr Ala Trp Gly Ala Lys 
    50                  55                  60                  


Asn Thr Ala Ala Leu Leu Ala Glu Ile Glu Lys Gln Ile Gly Leu Pro 
65                  70                  75                  80  


Val Thr Arg Ala Val Ser Thr His Phe His Asp Asp Arg Val Gly Gly 
                85                  90                  95      


Val Asp Val Leu Arg Ala Ala Gly Val Ala Thr Tyr Ala Ser Pro Ser 
            100                 105                 110         


Thr Arg Arg Leu Ala Glu Val Glu Gly Asn Glu Ile Pro Thr His Ser 
        115                 120                 125             


Leu Asp Gly Leu Ser Ser Ser Gly Asp Ala Val Arg Phe Gly Pro Val 
    130                 135                 140                 


Glu Leu Phe Tyr Pro Gly Ala Ala His Ser Thr Asp Asn Leu Val Val 
145                 150                 155                 160 


Tyr Val Pro Ser Ala Ser Val Leu Tyr Gly Gly Cys Ala Ile Tyr Glu 
                165                 170                 175     


Leu Ser Arg Thr Ser Ala Gly Asn Val Ala Asp Ala Asp Leu Ala Glu 
            180                 185                 190         


Trp Pro Thr Ser Ile Glu Arg Ile Gln Gln His Tyr Pro Glu Ala Gln 
        195                 200                 205             


Phe Val Ile Pro Gly His Gly Leu Pro Gly Gly Leu Asp Leu Leu Lys 
    210                 215                 220                 


His Thr Thr Asn Val Val Lys Ala His Thr Asn 
225                 230                 235 


<210>  24
<211>  235
<212>  PRT
<213>  artificial

<220>
<223>  VIM-2  V1M Q34R E130D Q22N DCT236

<400>  24

Met Asp Ser Ser Gly Glu Tyr Pro Thr Val Ser Glu Ile Pro Val Gly 
1               5                   10                  15      


Glu Val Arg Leu Tyr Asn Ile Ala Asp Gly Val Trp Ser His Ile Ala 
            20                  25                  30          


Thr Arg Ser Phe Asp Gly Ala Val Tyr Pro Ser Asn Gly Leu Ile Val 
        35                  40                  45              


Arg Asp Gly Asp Glu Leu Leu Leu Ile Asp Thr Ala Trp Gly Ala Lys 
    50                  55                  60                  


Asn Thr Ala Ala Leu Leu Ala Glu Ile Glu Lys Gln Ile Gly Leu Pro 
65                  70                  75                  80  


Val Thr Arg Ala Val Ser Thr His Phe His Asp Asp Arg Val Gly Gly 
                85                  90                  95      


Val Asp Val Leu Arg Ala Ala Gly Val Ala Thr Tyr Ala Ser Pro Ser 
            100                 105                 110         


Thr Arg Arg Leu Ala Glu Val Glu Gly Asn Glu Ile Pro Thr His Ser 
        115                 120                 125             


Leu Asp Gly Leu Ser Ser Ser Gly Asp Ala Val Arg Phe Gly Pro Val 
    130                 135                 140                 


Glu Leu Phe Tyr Pro Gly Ala Ala His Ser Thr Asp Asn Leu Val Val 
145                 150                 155                 160 


Tyr Val Pro Ser Ala Ser Val Leu Tyr Gly Gly Cys Ala Ile Tyr Glu 
                165                 170                 175     


Leu Ser Arg Thr Ser Ala Gly Asn Val Ala Asp Ala Asp Leu Ala Glu 
            180                 185                 190         


Trp Pro Thr Ser Ile Glu Arg Ile Gln Gln His Tyr Pro Glu Ala Gln 
        195                 200                 205             


Phe Val Ile Pro Gly His Gly Leu Pro Gly Gly Leu Asp Leu Leu Lys 
    210                 215                 220                 


His Thr Thr Asn Val Val Lys Ala His Thr Asn 
225                 230                 235 


<210>  25
<211>  235
<212>  PRT
<213>  artificial

<220>
<223>  VIM-2  V1M Q34R E130D Q22H DCT236

<400>  25

Met Asp Ser Ser Gly Glu Tyr Pro Thr Val Ser Glu Ile Pro Val Gly 
1               5                   10                  15      


Glu Val Arg Leu Tyr His Ile Ala Asp Gly Val Trp Ser His Ile Ala 
            20                  25                  30          


Thr Arg Ser Phe Asp Gly Ala Val Tyr Pro Ser Asn Gly Leu Ile Val 
        35                  40                  45              


Arg Asp Gly Asp Glu Leu Leu Leu Ile Asp Thr Ala Trp Gly Ala Lys 
    50                  55                  60                  


Asn Thr Ala Ala Leu Leu Ala Glu Ile Glu Lys Gln Ile Gly Leu Pro 
65                  70                  75                  80  


Val Thr Arg Ala Val Ser Thr His Phe His Asp Asp Arg Val Gly Gly 
                85                  90                  95      


Val Asp Val Leu Arg Ala Ala Gly Val Ala Thr Tyr Ala Ser Pro Ser 
            100                 105                 110         


Thr Arg Arg Leu Ala Glu Val Glu Gly Asn Glu Ile Pro Thr His Ser 
        115                 120                 125             


Leu Asp Gly Leu Ser Ser Ser Gly Asp Ala Val Arg Phe Gly Pro Val 
    130                 135                 140                 


Glu Leu Phe Tyr Pro Gly Ala Ala His Ser Thr Asp Asn Leu Val Val 
145                 150                 155                 160 


Tyr Val Pro Ser Ala Ser Val Leu Tyr Gly Gly Cys Ala Ile Tyr Glu 
                165                 170                 175     


Leu Ser Arg Thr Ser Ala Gly Asn Val Ala Asp Ala Asp Leu Ala Glu 
            180                 185                 190         


Trp Pro Thr Ser Ile Glu Arg Ile Gln Gln His Tyr Pro Glu Ala Gln 
        195                 200                 205             


Phe Val Ile Pro Gly His Gly Leu Pro Gly Gly Leu Asp Leu Leu Lys 
    210                 215                 220                 


His Thr Thr Asn Val Val Lys Ala His Thr Asn 
225                 230                 235 


<210>  26
<211>  240
<212>  PRT
<213>  artificial

<220>
<223>  VIM-2 V10A

<400>  26

Val Asp Ser Ser Gly Glu Tyr Pro Thr Ala Ser Glu Ile Pro Val Gly 
1               5                   10                  15      


Glu Val Arg Leu Tyr Gln Ile Ala Asp Gly Val Trp Ser His Ile Ala 
            20                  25                  30          


Thr Gln Ser Phe Asp Gly Ala Val Tyr Pro Ser Asn Gly Leu Ile Val 
        35                  40                  45              


Arg Asp Gly Asp Glu Leu Leu Leu Ile Asp Thr Ala Trp Gly Ala Lys 
    50                  55                  60                  


Asn Thr Ala Ala Leu Leu Ala Glu Ile Glu Lys Gln Ile Gly Leu Pro 
65                  70                  75                  80  


Val Thr Arg Ala Val Ser Thr His Phe His Asp Asp Arg Val Gly Gly 
                85                  90                  95      


Val Asp Val Leu Arg Ala Ala Gly Val Ala Thr Tyr Ala Ser Pro Ser 
            100                 105                 110         


Thr Arg Arg Leu Ala Glu Val Glu Gly Asn Glu Ile Pro Thr His Ser 
        115                 120                 125             


Leu Glu Gly Leu Ser Ser Ser Gly Asp Ala Val Arg Phe Gly Pro Val 
    130                 135                 140                 


Glu Leu Phe Tyr Pro Gly Ala Ala His Ser Thr Asp Asn Leu Val Val 
145                 150                 155                 160 


Tyr Val Pro Ser Ala Ser Val Leu Tyr Gly Gly Cys Ala Ile Tyr Glu 
                165                 170                 175     


Leu Ser Arg Thr Ser Ala Gly Asn Val Ala Asp Ala Asp Leu Ala Glu 
            180                 185                 190         


Trp Pro Thr Ser Ile Glu Arg Ile Gln Gln His Tyr Pro Glu Ala Gln 
        195                 200                 205             


Phe Val Ile Pro Gly His Gly Leu Pro Gly Gly Leu Asp Leu Leu Lys 
    210                 215                 220                 


His Thr Thr Asn Val Val Lys Ala His Thr Asn Arg Ser Val Val Glu 
225                 230                 235                 240 


<210>  27
<211>  240
<212>  PRT
<213>  artificial

<220>
<223>  VIM-2 V10A Q34R Q22H

<400>  27

Val Asp Ser Ser Gly Glu Tyr Pro Thr Ala Ser Glu Ile Pro Val Gly 
1               5                   10                  15      


Glu Val Arg Leu Tyr His Ile Ala Asp Gly Val Trp Ser His Ile Ala 
            20                  25                  30          


Thr Arg Ser Phe Asp Gly Ala Val Tyr Pro Ser Asn Gly Leu Ile Val 
        35                  40                  45              


Arg Asp Gly Asp Glu Leu Leu Leu Ile Asp Thr Ala Trp Gly Ala Lys 
    50                  55                  60                  


Asn Thr Ala Ala Leu Leu Ala Glu Ile Glu Lys Gln Ile Gly Leu Pro 
65                  70                  75                  80  


Val Thr Arg Ala Val Ser Thr His Phe His Asp Asp Arg Val Gly Gly 
                85                  90                  95      


Val Asp Val Leu Arg Ala Ala Gly Val Ala Thr Tyr Ala Ser Pro Ser 
            100                 105                 110         


Thr Arg Arg Leu Ala Glu Val Glu Gly Asn Glu Ile Pro Thr His Ser 
        115                 120                 125             


Leu Glu Gly Leu Ser Ser Ser Gly Asp Ala Val Arg Phe Gly Pro Val 
    130                 135                 140                 


Glu Leu Phe Tyr Pro Gly Ala Ala His Ser Thr Asp Asn Leu Val Val 
145                 150                 155                 160 


Tyr Val Pro Ser Ala Ser Val Leu Tyr Gly Gly Cys Ala Ile Tyr Glu 
                165                 170                 175     


Leu Ser Arg Thr Ser Ala Gly Asn Val Ala Asp Ala Asp Leu Ala Glu 
            180                 185                 190         


Trp Pro Thr Ser Ile Glu Arg Ile Gln Gln His Tyr Pro Glu Ala Gln 
        195                 200                 205             


Phe Val Ile Pro Gly His Gly Leu Pro Gly Gly Leu Asp Leu Leu Lys 
    210                 215                 220                 


His Thr Thr Asn Val Val Lys Ala His Thr Asn Arg Ser Val Val Glu 
225                 230                 235                 240 


<210>  28
<211>  240
<212>  PRT
<213>  artificial

<220>
<223>  VIM-2 V10A Q34R Q22N

<400>  28

Val Asp Ser Ser Gly Glu Tyr Pro Thr Ala Ser Glu Ile Pro Val Gly 
1               5                   10                  15      


Glu Val Arg Leu Tyr Asn Ile Ala Asp Gly Val Trp Ser His Ile Ala 
            20                  25                  30          


Thr Arg Ser Phe Asp Gly Ala Val Tyr Pro Ser Asn Gly Leu Ile Val 
        35                  40                  45              


Arg Asp Gly Asp Glu Leu Leu Leu Ile Asp Thr Ala Trp Gly Ala Lys 
    50                  55                  60                  


Asn Thr Ala Ala Leu Leu Ala Glu Ile Glu Lys Gln Ile Gly Leu Pro 
65                  70                  75                  80  


Val Thr Arg Ala Val Ser Thr His Phe His Asp Asp Arg Val Gly Gly 
                85                  90                  95      


Val Asp Val Leu Arg Ala Ala Gly Val Ala Thr Tyr Ala Ser Pro Ser 
            100                 105                 110         


Thr Arg Arg Leu Ala Glu Val Glu Gly Asn Glu Ile Pro Thr His Ser 
        115                 120                 125             


Leu Glu Gly Leu Ser Ser Ser Gly Asp Ala Val Arg Phe Gly Pro Val 
    130                 135                 140                 


Glu Leu Phe Tyr Pro Gly Ala Ala His Ser Thr Asp Asn Leu Val Val 
145                 150                 155                 160 


Tyr Val Pro Ser Ala Ser Val Leu Tyr Gly Gly Cys Ala Ile Tyr Glu 
                165                 170                 175     


Leu Ser Arg Thr Ser Ala Gly Asn Val Ala Asp Ala Asp Leu Ala Glu 
            180                 185                 190         


Trp Pro Thr Ser Ile Glu Arg Ile Gln Gln His Tyr Pro Glu Ala Gln 
        195                 200                 205             


Phe Val Ile Pro Gly His Gly Leu Pro Gly Gly Leu Asp Leu Leu Lys 
    210                 215                 220                 


His Thr Thr Asn Val Val Lys Ala His Thr Asn Arg Ser Val Val Glu 
225                 230                 235                 240 


<210>  29
<211>  240
<212>  PRT
<213>  artificial

<220>
<223>  VIM-2 V10A Q34R E130D

<400>  29

Val Asp Ser Ser Gly Glu Tyr Pro Thr Ala Ser Glu Ile Pro Val Gly 
1               5                   10                  15      


Glu Val Arg Leu Tyr Gln Ile Ala Asp Gly Val Trp Ser His Ile Ala 
            20                  25                  30          


Thr Arg Ser Phe Asp Gly Ala Val Tyr Pro Ser Asn Gly Leu Ile Val 
        35                  40                  45              


Arg Asp Gly Asp Glu Leu Leu Leu Ile Asp Thr Ala Trp Gly Ala Lys 
    50                  55                  60                  


Asn Thr Ala Ala Leu Leu Ala Glu Ile Glu Lys Gln Ile Gly Leu Pro 
65                  70                  75                  80  


Val Thr Arg Ala Val Ser Thr His Phe His Asp Asp Arg Val Gly Gly 
                85                  90                  95      


Val Asp Val Leu Arg Ala Ala Gly Val Ala Thr Tyr Ala Ser Pro Ser 
            100                 105                 110         


Thr Arg Arg Leu Ala Glu Val Glu Gly Asn Glu Ile Pro Thr His Ser 
        115                 120                 125             


Leu Asp Gly Leu Ser Ser Ser Gly Asp Ala Val Arg Phe Gly Pro Val 
    130                 135                 140                 


Glu Leu Phe Tyr Pro Gly Ala Ala His Ser Thr Asp Asn Leu Val Val 
145                 150                 155                 160 


Tyr Val Pro Ser Ala Ser Val Leu Tyr Gly Gly Cys Ala Ile Tyr Glu 
                165                 170                 175     


Leu Ser Arg Thr Ser Ala Gly Asn Val Ala Asp Ala Asp Leu Ala Glu 
            180                 185                 190         


Trp Pro Thr Ser Ile Glu Arg Ile Gln Gln His Tyr Pro Glu Ala Gln 
        195                 200                 205             


Phe Val Ile Pro Gly His Gly Leu Pro Gly Gly Leu Asp Leu Leu Lys 
    210                 215                 220                 


His Thr Thr Asn Val Val Lys Ala His Thr Asn Arg Ser Val Val Glu 
225                 230                 235                 240 


<210>  30
<211>  240
<212>  PRT
<213>  artificial

<220>
<223>  VIM-2 V10A Q34R E130D Q22N

<400>  30

Val Asp Ser Ser Gly Glu Tyr Pro Thr Ala Ser Glu Ile Pro Val Gly 
1               5                   10                  15      


Glu Val Arg Leu Tyr Asn Ile Ala Asp Gly Val Trp Ser His Ile Ala 
            20                  25                  30          


Thr Arg Ser Phe Asp Gly Ala Val Tyr Pro Ser Asn Gly Leu Ile Val 
        35                  40                  45              


Arg Asp Gly Asp Glu Leu Leu Leu Ile Asp Thr Ala Trp Gly Ala Lys 
    50                  55                  60                  


Asn Thr Ala Ala Leu Leu Ala Glu Ile Glu Lys Gln Ile Gly Leu Pro 
65                  70                  75                  80  


Val Thr Arg Ala Val Ser Thr His Phe His Asp Asp Arg Val Gly Gly 
                85                  90                  95      


Val Asp Val Leu Arg Ala Ala Gly Val Ala Thr Tyr Ala Ser Pro Ser 
            100                 105                 110         


Thr Arg Arg Leu Ala Glu Val Glu Gly Asn Glu Ile Pro Thr His Ser 
        115                 120                 125             


Leu Asp Gly Leu Ser Ser Ser Gly Asp Ala Val Arg Phe Gly Pro Val 
    130                 135                 140                 


Glu Leu Phe Tyr Pro Gly Ala Ala His Ser Thr Asp Asn Leu Val Val 
145                 150                 155                 160 


Tyr Val Pro Ser Ala Ser Val Leu Tyr Gly Gly Cys Ala Ile Tyr Glu 
                165                 170                 175     


Leu Ser Arg Thr Ser Ala Gly Asn Val Ala Asp Ala Asp Leu Ala Glu 
            180                 185                 190         


Trp Pro Thr Ser Ile Glu Arg Ile Gln Gln His Tyr Pro Glu Ala Gln 
        195                 200                 205             


Phe Val Ile Pro Gly His Gly Leu Pro Gly Gly Leu Asp Leu Leu Lys 
    210                 215                 220                 


His Thr Thr Asn Val Val Lys Ala His Thr Asn Arg Ser Val Val Glu 
225                 230                 235                 240 


<210>  31
<211>  240
<212>  PRT
<213>  artificial

<220>
<223>  VIM-2 V10A Q34R E130D Q22H

<400>  31

Val Asp Ser Ser Gly Glu Tyr Pro Thr Ala Ser Glu Ile Pro Val Gly 
1               5                   10                  15      


Glu Val Arg Leu Tyr His Ile Ala Asp Gly Val Trp Ser His Ile Ala 
            20                  25                  30          


Thr Arg Ser Phe Asp Gly Ala Val Tyr Pro Ser Asn Gly Leu Ile Val 
        35                  40                  45              


Arg Asp Gly Asp Glu Leu Leu Leu Ile Asp Thr Ala Trp Gly Ala Lys 
    50                  55                  60                  


Asn Thr Ala Ala Leu Leu Ala Glu Ile Glu Lys Gln Ile Gly Leu Pro 
65                  70                  75                  80  


Val Thr Arg Ala Val Ser Thr His Phe His Asp Asp Arg Val Gly Gly 
                85                  90                  95      


Val Asp Val Leu Arg Ala Ala Gly Val Ala Thr Tyr Ala Ser Pro Ser 
            100                 105                 110         


Thr Arg Arg Leu Ala Glu Val Glu Gly Asn Glu Ile Pro Thr His Ser 
        115                 120                 125             


Leu Asp Gly Leu Ser Ser Ser Gly Asp Ala Val Arg Phe Gly Pro Val 
    130                 135                 140                 


Glu Leu Phe Tyr Pro Gly Ala Ala His Ser Thr Asp Asn Leu Val Val 
145                 150                 155                 160 


Tyr Val Pro Ser Ala Ser Val Leu Tyr Gly Gly Cys Ala Ile Tyr Glu 
                165                 170                 175     


Leu Ser Arg Thr Ser Ala Gly Asn Val Ala Asp Ala Asp Leu Ala Glu 
            180                 185                 190         


Trp Pro Thr Ser Ile Glu Arg Ile Gln Gln His Tyr Pro Glu Ala Gln 
        195                 200                 205             


Phe Val Ile Pro Gly His Gly Leu Pro Gly Gly Leu Asp Leu Leu Lys 
    210                 215                 220                 


His Thr Thr Asn Val Val Lys Ala His Thr Asn Arg Ser Val Val Glu 
225                 230                 235                 240 


<210>  32
<211>  235
<212>  PRT
<213>  artificial

<220>
<223>  VIM-2 V10A Q34R Q22H DCT236

<400>  32

Val Asp Ser Ser Gly Glu Tyr Pro Thr Ala Ser Glu Ile Pro Val Gly 
1               5                   10                  15      


Glu Val Arg Leu Tyr His Ile Ala Asp Gly Val Trp Ser His Ile Ala 
            20                  25                  30          


Thr Arg Ser Phe Asp Gly Ala Val Tyr Pro Ser Asn Gly Leu Ile Val 
        35                  40                  45              


Arg Asp Gly Asp Glu Leu Leu Leu Ile Asp Thr Ala Trp Gly Ala Lys 
    50                  55                  60                  


Asn Thr Ala Ala Leu Leu Ala Glu Ile Glu Lys Gln Ile Gly Leu Pro 
65                  70                  75                  80  


Val Thr Arg Ala Val Ser Thr His Phe His Asp Asp Arg Val Gly Gly 
                85                  90                  95      


Val Asp Val Leu Arg Ala Ala Gly Val Ala Thr Tyr Ala Ser Pro Ser 
            100                 105                 110         


Thr Arg Arg Leu Ala Glu Val Glu Gly Asn Glu Ile Pro Thr His Ser 
        115                 120                 125             


Leu Glu Gly Leu Ser Ser Ser Gly Asp Ala Val Arg Phe Gly Pro Val 
    130                 135                 140                 


Glu Leu Phe Tyr Pro Gly Ala Ala His Ser Thr Asp Asn Leu Val Val 
145                 150                 155                 160 


Tyr Val Pro Ser Ala Ser Val Leu Tyr Gly Gly Cys Ala Ile Tyr Glu 
                165                 170                 175     


Leu Ser Arg Thr Ser Ala Gly Asn Val Ala Asp Ala Asp Leu Ala Glu 
            180                 185                 190         


Trp Pro Thr Ser Ile Glu Arg Ile Gln Gln His Tyr Pro Glu Ala Gln 
        195                 200                 205             


Phe Val Ile Pro Gly His Gly Leu Pro Gly Gly Leu Asp Leu Leu Lys 
    210                 215                 220                 


His Thr Thr Asn Val Val Lys Ala His Thr Asn 
225                 230                 235 


<210>  33
<211>  235
<212>  PRT
<213>  artificial

<220>
<223>  VIM-2 V10A Q34R Q22N DCT236

<400>  33

Val Asp Ser Ser Gly Glu Tyr Pro Thr Ala Ser Glu Ile Pro Val Gly 
1               5                   10                  15      


Glu Val Arg Leu Tyr Asn Ile Ala Asp Gly Val Trp Ser His Ile Ala 
            20                  25                  30          


Thr Arg Ser Phe Asp Gly Ala Val Tyr Pro Ser Asn Gly Leu Ile Val 
        35                  40                  45              


Arg Asp Gly Asp Glu Leu Leu Leu Ile Asp Thr Ala Trp Gly Ala Lys 
    50                  55                  60                  


Asn Thr Ala Ala Leu Leu Ala Glu Ile Glu Lys Gln Ile Gly Leu Pro 
65                  70                  75                  80  


Val Thr Arg Ala Val Ser Thr His Phe His Asp Asp Arg Val Gly Gly 
                85                  90                  95      


Val Asp Val Leu Arg Ala Ala Gly Val Ala Thr Tyr Ala Ser Pro Ser 
            100                 105                 110         


Thr Arg Arg Leu Ala Glu Val Glu Gly Asn Glu Ile Pro Thr His Ser 
        115                 120                 125             


Leu Glu Gly Leu Ser Ser Ser Gly Asp Ala Val Arg Phe Gly Pro Val 
    130                 135                 140                 


Glu Leu Phe Tyr Pro Gly Ala Ala His Ser Thr Asp Asn Leu Val Val 
145                 150                 155                 160 


Tyr Val Pro Ser Ala Ser Val Leu Tyr Gly Gly Cys Ala Ile Tyr Glu 
                165                 170                 175     


Leu Ser Arg Thr Ser Ala Gly Asn Val Ala Asp Ala Asp Leu Ala Glu 
            180                 185                 190         


Trp Pro Thr Ser Ile Glu Arg Ile Gln Gln His Tyr Pro Glu Ala Gln 
        195                 200                 205             


Phe Val Ile Pro Gly His Gly Leu Pro Gly Gly Leu Asp Leu Leu Lys 
    210                 215                 220                 


His Thr Thr Asn Val Val Lys Ala His Thr Asn 
225                 230                 235 


<210>  34
<211>  235
<212>  PRT
<213>  artificial

<220>
<223>  VIM-2 V10A Q34R E130D DCT236

<400>  34

Val Asp Ser Ser Gly Glu Tyr Pro Thr Ala Ser Glu Ile Pro Val Gly 
1               5                   10                  15      


Glu Val Arg Leu Tyr Gln Ile Ala Asp Gly Val Trp Ser His Ile Ala 
            20                  25                  30          


Thr Arg Ser Phe Asp Gly Ala Val Tyr Pro Ser Asn Gly Leu Ile Val 
        35                  40                  45              


Arg Asp Gly Asp Glu Leu Leu Leu Ile Asp Thr Ala Trp Gly Ala Lys 
    50                  55                  60                  


Asn Thr Ala Ala Leu Leu Ala Glu Ile Glu Lys Gln Ile Gly Leu Pro 
65                  70                  75                  80  


Val Thr Arg Ala Val Ser Thr His Phe His Asp Asp Arg Val Gly Gly 
                85                  90                  95      


Val Asp Val Leu Arg Ala Ala Gly Val Ala Thr Tyr Ala Ser Pro Ser 
            100                 105                 110         


Thr Arg Arg Leu Ala Glu Val Glu Gly Asn Glu Ile Pro Thr His Ser 
        115                 120                 125             


Leu Asp Gly Leu Ser Ser Ser Gly Asp Ala Val Arg Phe Gly Pro Val 
    130                 135                 140                 


Glu Leu Phe Tyr Pro Gly Ala Ala His Ser Thr Asp Asn Leu Val Val 
145                 150                 155                 160 


Tyr Val Pro Ser Ala Ser Val Leu Tyr Gly Gly Cys Ala Ile Tyr Glu 
                165                 170                 175     


Leu Ser Arg Thr Ser Ala Gly Asn Val Ala Asp Ala Asp Leu Ala Glu 
            180                 185                 190         


Trp Pro Thr Ser Ile Glu Arg Ile Gln Gln His Tyr Pro Glu Ala Gln 
        195                 200                 205             


Phe Val Ile Pro Gly His Gly Leu Pro Gly Gly Leu Asp Leu Leu Lys 
    210                 215                 220                 


His Thr Thr Asn Val Val Lys Ala His Thr Asn 
225                 230                 235 


<210>  35
<211>  235
<212>  PRT
<213>  artificial

<220>
<223>  VIM-2 V10A Q34R E130D Q22N DCT236

<400>  35

Val Asp Ser Ser Gly Glu Tyr Pro Thr Ala Ser Glu Ile Pro Val Gly 
1               5                   10                  15      


Glu Val Arg Leu Tyr Asn Ile Ala Asp Gly Val Trp Ser His Ile Ala 
            20                  25                  30          


Thr Arg Ser Phe Asp Gly Ala Val Tyr Pro Ser Asn Gly Leu Ile Val 
        35                  40                  45              


Arg Asp Gly Asp Glu Leu Leu Leu Ile Asp Thr Ala Trp Gly Ala Lys 
    50                  55                  60                  


Asn Thr Ala Ala Leu Leu Ala Glu Ile Glu Lys Gln Ile Gly Leu Pro 
65                  70                  75                  80  


Val Thr Arg Ala Val Ser Thr His Phe His Asp Asp Arg Val Gly Gly 
                85                  90                  95      


Val Asp Val Leu Arg Ala Ala Gly Val Ala Thr Tyr Ala Ser Pro Ser 
            100                 105                 110         


Thr Arg Arg Leu Ala Glu Val Glu Gly Asn Glu Ile Pro Thr His Ser 
        115                 120                 125             


Leu Asp Gly Leu Ser Ser Ser Gly Asp Ala Val Arg Phe Gly Pro Val 
    130                 135                 140                 


Glu Leu Phe Tyr Pro Gly Ala Ala His Ser Thr Asp Asn Leu Val Val 
145                 150                 155                 160 


Tyr Val Pro Ser Ala Ser Val Leu Tyr Gly Gly Cys Ala Ile Tyr Glu 
                165                 170                 175     


Leu Ser Arg Thr Ser Ala Gly Asn Val Ala Asp Ala Asp Leu Ala Glu 
            180                 185                 190         


Trp Pro Thr Ser Ile Glu Arg Ile Gln Gln His Tyr Pro Glu Ala Gln 
        195                 200                 205             


Phe Val Ile Pro Gly His Gly Leu Pro Gly Gly Leu Asp Leu Leu Lys 
    210                 215                 220                 


His Thr Thr Asn Val Val Lys Ala His Thr Asn 
225                 230                 235 


<210>  36
<211>  235
<212>  PRT
<213>  artificial

<220>
<223>  VIM-2 V10A Q34R E130D Q22H DCT236

<400>  36

Val Asp Ser Ser Gly Glu Tyr Pro Thr Ala Ser Glu Ile Pro Val Gly 
1               5                   10                  15      


Glu Val Arg Leu Tyr His Ile Ala Asp Gly Val Trp Ser His Ile Ala 
            20                  25                  30          


Thr Arg Ser Phe Asp Gly Ala Val Tyr Pro Ser Asn Gly Leu Ile Val 
        35                  40                  45              


Arg Asp Gly Asp Glu Leu Leu Leu Ile Asp Thr Ala Trp Gly Ala Lys 
    50                  55                  60                  


Asn Thr Ala Ala Leu Leu Ala Glu Ile Glu Lys Gln Ile Gly Leu Pro 
65                  70                  75                  80  


Val Thr Arg Ala Val Ser Thr His Phe His Asp Asp Arg Val Gly Gly 
                85                  90                  95      


Val Asp Val Leu Arg Ala Ala Gly Val Ala Thr Tyr Ala Ser Pro Ser 
            100                 105                 110         


Thr Arg Arg Leu Ala Glu Val Glu Gly Asn Glu Ile Pro Thr His Ser 
        115                 120                 125             


Leu Asp Gly Leu Ser Ser Ser Gly Asp Ala Val Arg Phe Gly Pro Val 
    130                 135                 140                 


Glu Leu Phe Tyr Pro Gly Ala Ala His Ser Thr Asp Asn Leu Val Val 
145                 150                 155                 160 


Tyr Val Pro Ser Ala Ser Val Leu Tyr Gly Gly Cys Ala Ile Tyr Glu 
                165                 170                 175     


Leu Ser Arg Thr Ser Ala Gly Asn Val Ala Asp Ala Asp Leu Ala Glu 
            180                 185                 190         


Trp Pro Thr Ser Ile Glu Arg Ile Gln Gln His Tyr Pro Glu Ala Gln 
        195                 200                 205             


Phe Val Ile Pro Gly His Gly Leu Pro Gly Gly Leu Asp Leu Leu Lys 
    210                 215                 220                 


His Thr Thr Asn Val Val Lys Ala His Thr Asn 
225                 230                 235 


<210>  37
<211>  240
<212>  PRT
<213>  artificial

<220>
<223>  VIM-2 V10A V1M Q34R Q22H

<400>  37

Met Asp Ser Ser Gly Glu Tyr Pro Thr Ala Ser Glu Ile Pro Val Gly 
1               5                   10                  15      


Glu Val Arg Leu Tyr His Ile Ala Asp Gly Val Trp Ser His Ile Ala 
            20                  25                  30          


Thr Arg Ser Phe Asp Gly Ala Val Tyr Pro Ser Asn Gly Leu Ile Val 
        35                  40                  45              


Arg Asp Gly Asp Glu Leu Leu Leu Ile Asp Thr Ala Trp Gly Ala Lys 
    50                  55                  60                  


Asn Thr Ala Ala Leu Leu Ala Glu Ile Glu Lys Gln Ile Gly Leu Pro 
65                  70                  75                  80  


Val Thr Arg Ala Val Ser Thr His Phe His Asp Asp Arg Val Gly Gly 
                85                  90                  95      


Val Asp Val Leu Arg Ala Ala Gly Val Ala Thr Tyr Ala Ser Pro Ser 
            100                 105                 110         


Thr Arg Arg Leu Ala Glu Val Glu Gly Asn Glu Ile Pro Thr His Ser 
        115                 120                 125             


Leu Glu Gly Leu Ser Ser Ser Gly Asp Ala Val Arg Phe Gly Pro Val 
    130                 135                 140                 


Glu Leu Phe Tyr Pro Gly Ala Ala His Ser Thr Asp Asn Leu Val Val 
145                 150                 155                 160 


Tyr Val Pro Ser Ala Ser Val Leu Tyr Gly Gly Cys Ala Ile Tyr Glu 
                165                 170                 175     


Leu Ser Arg Thr Ser Ala Gly Asn Val Ala Asp Ala Asp Leu Ala Glu 
            180                 185                 190         


Trp Pro Thr Ser Ile Glu Arg Ile Gln Gln His Tyr Pro Glu Ala Gln 
        195                 200                 205             


Phe Val Ile Pro Gly His Gly Leu Pro Gly Gly Leu Asp Leu Leu Lys 
    210                 215                 220                 


His Thr Thr Asn Val Val Lys Ala His Thr Asn Arg Ser Val Val Glu 
225                 230                 235                 240 


<210>  38
<211>  240
<212>  PRT
<213>  artificial

<220>
<223>  VIM-2 V10A V1M Q34R Q22N

<400>  38

Met Asp Ser Ser Gly Glu Tyr Pro Thr Ala Ser Glu Ile Pro Val Gly 
1               5                   10                  15      


Glu Val Arg Leu Tyr Asn Ile Ala Asp Gly Val Trp Ser His Ile Ala 
            20                  25                  30          


Thr Arg Ser Phe Asp Gly Ala Val Tyr Pro Ser Asn Gly Leu Ile Val 
        35                  40                  45              


Arg Asp Gly Asp Glu Leu Leu Leu Ile Asp Thr Ala Trp Gly Ala Lys 
    50                  55                  60                  


Asn Thr Ala Ala Leu Leu Ala Glu Ile Glu Lys Gln Ile Gly Leu Pro 
65                  70                  75                  80  


Val Thr Arg Ala Val Ser Thr His Phe His Asp Asp Arg Val Gly Gly 
                85                  90                  95      


Val Asp Val Leu Arg Ala Ala Gly Val Ala Thr Tyr Ala Ser Pro Ser 
            100                 105                 110         


Thr Arg Arg Leu Ala Glu Val Glu Gly Asn Glu Ile Pro Thr His Ser 
        115                 120                 125             


Leu Glu Gly Leu Ser Ser Ser Gly Asp Ala Val Arg Phe Gly Pro Val 
    130                 135                 140                 


Glu Leu Phe Tyr Pro Gly Ala Ala His Ser Thr Asp Asn Leu Val Val 
145                 150                 155                 160 


Tyr Val Pro Ser Ala Ser Val Leu Tyr Gly Gly Cys Ala Ile Tyr Glu 
                165                 170                 175     


Leu Ser Arg Thr Ser Ala Gly Asn Val Ala Asp Ala Asp Leu Ala Glu 
            180                 185                 190         


Trp Pro Thr Ser Ile Glu Arg Ile Gln Gln His Tyr Pro Glu Ala Gln 
        195                 200                 205             


Phe Val Ile Pro Gly His Gly Leu Pro Gly Gly Leu Asp Leu Leu Lys 
    210                 215                 220                 


His Thr Thr Asn Val Val Lys Ala His Thr Asn Arg Ser Val Val Glu 
225                 230                 235                 240 


<210>  39
<211>  240
<212>  PRT
<213>  artificial

<220>
<223>  VIM-2 V10A V1M Q34R E130D

<400>  39

Met Asp Ser Ser Gly Glu Tyr Pro Thr Ala Ser Glu Ile Pro Val Gly 
1               5                   10                  15      


Glu Val Arg Leu Tyr Gln Ile Ala Asp Gly Val Trp Ser His Ile Ala 
            20                  25                  30          


Thr Arg Ser Phe Asp Gly Ala Val Tyr Pro Ser Asn Gly Leu Ile Val 
        35                  40                  45              


Arg Asp Gly Asp Glu Leu Leu Leu Ile Asp Thr Ala Trp Gly Ala Lys 
    50                  55                  60                  


Asn Thr Ala Ala Leu Leu Ala Glu Ile Glu Lys Gln Ile Gly Leu Pro 
65                  70                  75                  80  


Val Thr Arg Ala Val Ser Thr His Phe His Asp Asp Arg Val Gly Gly 
                85                  90                  95      


Val Asp Val Leu Arg Ala Ala Gly Val Ala Thr Tyr Ala Ser Pro Ser 
            100                 105                 110         


Thr Arg Arg Leu Ala Glu Val Glu Gly Asn Glu Ile Pro Thr His Ser 
        115                 120                 125             


Leu Asp Gly Leu Ser Ser Ser Gly Asp Ala Val Arg Phe Gly Pro Val 
    130                 135                 140                 


Glu Leu Phe Tyr Pro Gly Ala Ala His Ser Thr Asp Asn Leu Val Val 
145                 150                 155                 160 


Tyr Val Pro Ser Ala Ser Val Leu Tyr Gly Gly Cys Ala Ile Tyr Glu 
                165                 170                 175     


Leu Ser Arg Thr Ser Ala Gly Asn Val Ala Asp Ala Asp Leu Ala Glu 
            180                 185                 190         


Trp Pro Thr Ser Ile Glu Arg Ile Gln Gln His Tyr Pro Glu Ala Gln 
        195                 200                 205             


Phe Val Ile Pro Gly His Gly Leu Pro Gly Gly Leu Asp Leu Leu Lys 
    210                 215                 220                 


His Thr Thr Asn Val Val Lys Ala His Thr Asn Arg Ser Val Val Glu 
225                 230                 235                 240 


<210>  40
<211>  240
<212>  PRT
<213>  artificial

<220>
<223>  VIM-2 V10A V1M Q34R E130D Q22N

<400>  40

Met Asp Ser Ser Gly Glu Tyr Pro Thr Ala Ser Glu Ile Pro Val Gly 
1               5                   10                  15      


Glu Val Arg Leu Tyr Asn Ile Ala Asp Gly Val Trp Ser His Ile Ala 
            20                  25                  30          


Thr Arg Ser Phe Asp Gly Ala Val Tyr Pro Ser Asn Gly Leu Ile Val 
        35                  40                  45              


Arg Asp Gly Asp Glu Leu Leu Leu Ile Asp Thr Ala Trp Gly Ala Lys 
    50                  55                  60                  


Asn Thr Ala Ala Leu Leu Ala Glu Ile Glu Lys Gln Ile Gly Leu Pro 
65                  70                  75                  80  


Val Thr Arg Ala Val Ser Thr His Phe His Asp Asp Arg Val Gly Gly 
                85                  90                  95      


Val Asp Val Leu Arg Ala Ala Gly Val Ala Thr Tyr Ala Ser Pro Ser 
            100                 105                 110         


Thr Arg Arg Leu Ala Glu Val Glu Gly Asn Glu Ile Pro Thr His Ser 
        115                 120                 125             


Leu Asp Gly Leu Ser Ser Ser Gly Asp Ala Val Arg Phe Gly Pro Val 
    130                 135                 140                 


Glu Leu Phe Tyr Pro Gly Ala Ala His Ser Thr Asp Asn Leu Val Val 
145                 150                 155                 160 


Tyr Val Pro Ser Ala Ser Val Leu Tyr Gly Gly Cys Ala Ile Tyr Glu 
                165                 170                 175     


Leu Ser Arg Thr Ser Ala Gly Asn Val Ala Asp Ala Asp Leu Ala Glu 
            180                 185                 190         


Trp Pro Thr Ser Ile Glu Arg Ile Gln Gln His Tyr Pro Glu Ala Gln 
        195                 200                 205             


Phe Val Ile Pro Gly His Gly Leu Pro Gly Gly Leu Asp Leu Leu Lys 
    210                 215                 220                 


His Thr Thr Asn Val Val Lys Ala His Thr Asn Arg Ser Val Val Glu 
225                 230                 235                 240 


<210>  41
<211>  240
<212>  PRT
<213>  artificial

<220>
<223>  VIM-2 V10A V1M Q34R E130D Q22H

<400>  41

Met Asp Ser Ser Gly Glu Tyr Pro Thr Ala Ser Glu Ile Pro Val Gly 
1               5                   10                  15      


Glu Val Arg Leu Tyr His Ile Ala Asp Gly Val Trp Ser His Ile Ala 
            20                  25                  30          


Thr Arg Ser Phe Asp Gly Ala Val Tyr Pro Ser Asn Gly Leu Ile Val 
        35                  40                  45              


Arg Asp Gly Asp Glu Leu Leu Leu Ile Asp Thr Ala Trp Gly Ala Lys 
    50                  55                  60                  


Asn Thr Ala Ala Leu Leu Ala Glu Ile Glu Lys Gln Ile Gly Leu Pro 
65                  70                  75                  80  


Val Thr Arg Ala Val Ser Thr His Phe His Asp Asp Arg Val Gly Gly 
                85                  90                  95      


Val Asp Val Leu Arg Ala Ala Gly Val Ala Thr Tyr Ala Ser Pro Ser 
            100                 105                 110         


Thr Arg Arg Leu Ala Glu Val Glu Gly Asn Glu Ile Pro Thr His Ser 
        115                 120                 125             


Leu Asp Gly Leu Ser Ser Ser Gly Asp Ala Val Arg Phe Gly Pro Val 
    130                 135                 140                 


Glu Leu Phe Tyr Pro Gly Ala Ala His Ser Thr Asp Asn Leu Val Val 
145                 150                 155                 160 


Tyr Val Pro Ser Ala Ser Val Leu Tyr Gly Gly Cys Ala Ile Tyr Glu 
                165                 170                 175     


Leu Ser Arg Thr Ser Ala Gly Asn Val Ala Asp Ala Asp Leu Ala Glu 
            180                 185                 190         


Trp Pro Thr Ser Ile Glu Arg Ile Gln Gln His Tyr Pro Glu Ala Gln 
        195                 200                 205             


Phe Val Ile Pro Gly His Gly Leu Pro Gly Gly Leu Asp Leu Leu Lys 
    210                 215                 220                 


His Thr Thr Asn Val Val Lys Ala His Thr Asn Arg Ser Val Val Glu 
225                 230                 235                 240 


<210>  42
<211>  235
<212>  PRT
<213>  artificial

<220>
<223>  VIM-2 V10A V1M Q34R Q22H DCT236

<400>  42

Met Asp Ser Ser Gly Glu Tyr Pro Thr Ala Ser Glu Ile Pro Val Gly 
1               5                   10                  15      


Glu Val Arg Leu Tyr His Ile Ala Asp Gly Val Trp Ser His Ile Ala 
            20                  25                  30          


Thr Arg Ser Phe Asp Gly Ala Val Tyr Pro Ser Asn Gly Leu Ile Val 
        35                  40                  45              


Arg Asp Gly Asp Glu Leu Leu Leu Ile Asp Thr Ala Trp Gly Ala Lys 
    50                  55                  60                  


Asn Thr Ala Ala Leu Leu Ala Glu Ile Glu Lys Gln Ile Gly Leu Pro 
65                  70                  75                  80  


Val Thr Arg Ala Val Ser Thr His Phe His Asp Asp Arg Val Gly Gly 
                85                  90                  95      


Val Asp Val Leu Arg Ala Ala Gly Val Ala Thr Tyr Ala Ser Pro Ser 
            100                 105                 110         


Thr Arg Arg Leu Ala Glu Val Glu Gly Asn Glu Ile Pro Thr His Ser 
        115                 120                 125             


Leu Glu Gly Leu Ser Ser Ser Gly Asp Ala Val Arg Phe Gly Pro Val 
    130                 135                 140                 


Glu Leu Phe Tyr Pro Gly Ala Ala His Ser Thr Asp Asn Leu Val Val 
145                 150                 155                 160 


Tyr Val Pro Ser Ala Ser Val Leu Tyr Gly Gly Cys Ala Ile Tyr Glu 
                165                 170                 175     


Leu Ser Arg Thr Ser Ala Gly Asn Val Ala Asp Ala Asp Leu Ala Glu 
            180                 185                 190         


Trp Pro Thr Ser Ile Glu Arg Ile Gln Gln His Tyr Pro Glu Ala Gln 
        195                 200                 205             


Phe Val Ile Pro Gly His Gly Leu Pro Gly Gly Leu Asp Leu Leu Lys 
    210                 215                 220                 


His Thr Thr Asn Val Val Lys Ala His Thr Asn 
225                 230                 235 


<210>  43
<211>  235
<212>  PRT
<213>  artificial

<220>
<223>  VIM-2 V10A V1M Q34R Q22N DCT236

<400>  43

Met Asp Ser Ser Gly Glu Tyr Pro Thr Ala Ser Glu Ile Pro Val Gly 
1               5                   10                  15      


Glu Val Arg Leu Tyr Asn Ile Ala Asp Gly Val Trp Ser His Ile Ala 
            20                  25                  30          


Thr Arg Ser Phe Asp Gly Ala Val Tyr Pro Ser Asn Gly Leu Ile Val 
        35                  40                  45              


Arg Asp Gly Asp Glu Leu Leu Leu Ile Asp Thr Ala Trp Gly Ala Lys 
    50                  55                  60                  


Asn Thr Ala Ala Leu Leu Ala Glu Ile Glu Lys Gln Ile Gly Leu Pro 
65                  70                  75                  80  


Val Thr Arg Ala Val Ser Thr His Phe His Asp Asp Arg Val Gly Gly 
                85                  90                  95      


Val Asp Val Leu Arg Ala Ala Gly Val Ala Thr Tyr Ala Ser Pro Ser 
            100                 105                 110         


Thr Arg Arg Leu Ala Glu Val Glu Gly Asn Glu Ile Pro Thr His Ser 
        115                 120                 125             


Leu Glu Gly Leu Ser Ser Ser Gly Asp Ala Val Arg Phe Gly Pro Val 
    130                 135                 140                 


Glu Leu Phe Tyr Pro Gly Ala Ala His Ser Thr Asp Asn Leu Val Val 
145                 150                 155                 160 


Tyr Val Pro Ser Ala Ser Val Leu Tyr Gly Gly Cys Ala Ile Tyr Glu 
                165                 170                 175     


Leu Ser Arg Thr Ser Ala Gly Asn Val Ala Asp Ala Asp Leu Ala Glu 
            180                 185                 190         


Trp Pro Thr Ser Ile Glu Arg Ile Gln Gln His Tyr Pro Glu Ala Gln 
        195                 200                 205             


Phe Val Ile Pro Gly His Gly Leu Pro Gly Gly Leu Asp Leu Leu Lys 
    210                 215                 220                 


His Thr Thr Asn Val Val Lys Ala His Thr Asn 
225                 230                 235 


<210>  44
<211>  235
<212>  PRT
<213>  artificial

<220>
<223>  VIM-2 V10A V1M Q34R E130D DCT236

<400>  44

Met Asp Ser Ser Gly Glu Tyr Pro Thr Ala Ser Glu Ile Pro Val Gly 
1               5                   10                  15      


Glu Val Arg Leu Tyr Gln Ile Ala Asp Gly Val Trp Ser His Ile Ala 
            20                  25                  30          


Thr Arg Ser Phe Asp Gly Ala Val Tyr Pro Ser Asn Gly Leu Ile Val 
        35                  40                  45              


Arg Asp Gly Asp Glu Leu Leu Leu Ile Asp Thr Ala Trp Gly Ala Lys 
    50                  55                  60                  


Asn Thr Ala Ala Leu Leu Ala Glu Ile Glu Lys Gln Ile Gly Leu Pro 
65                  70                  75                  80  


Val Thr Arg Ala Val Ser Thr His Phe His Asp Asp Arg Val Gly Gly 
                85                  90                  95      


Val Asp Val Leu Arg Ala Ala Gly Val Ala Thr Tyr Ala Ser Pro Ser 
            100                 105                 110         


Thr Arg Arg Leu Ala Glu Val Glu Gly Asn Glu Ile Pro Thr His Ser 
        115                 120                 125             


Leu Asp Gly Leu Ser Ser Ser Gly Asp Ala Val Arg Phe Gly Pro Val 
    130                 135                 140                 


Glu Leu Phe Tyr Pro Gly Ala Ala His Ser Thr Asp Asn Leu Val Val 
145                 150                 155                 160 


Tyr Val Pro Ser Ala Ser Val Leu Tyr Gly Gly Cys Ala Ile Tyr Glu 
                165                 170                 175     


Leu Ser Arg Thr Ser Ala Gly Asn Val Ala Asp Ala Asp Leu Ala Glu 
            180                 185                 190         


Trp Pro Thr Ser Ile Glu Arg Ile Gln Gln His Tyr Pro Glu Ala Gln 
        195                 200                 205             


Phe Val Ile Pro Gly His Gly Leu Pro Gly Gly Leu Asp Leu Leu Lys 
    210                 215                 220                 


His Thr Thr Asn Val Val Lys Ala His Thr Asn 
225                 230                 235 


<210>  45
<211>  235
<212>  PRT
<213>  artificial

<220>
<223>  VIM-2 V10A V1M Q34R E130D Q22N DCT236

<400>  45

Met Asp Ser Ser Gly Glu Tyr Pro Thr Ala Ser Glu Ile Pro Val Gly 
1               5                   10                  15      


Glu Val Arg Leu Tyr Asn Ile Ala Asp Gly Val Trp Ser His Ile Ala 
            20                  25                  30          


Thr Arg Ser Phe Asp Gly Ala Val Tyr Pro Ser Asn Gly Leu Ile Val 
        35                  40                  45              


Arg Asp Gly Asp Glu Leu Leu Leu Ile Asp Thr Ala Trp Gly Ala Lys 
    50                  55                  60                  


Asn Thr Ala Ala Leu Leu Ala Glu Ile Glu Lys Gln Ile Gly Leu Pro 
65                  70                  75                  80  


Val Thr Arg Ala Val Ser Thr His Phe His Asp Asp Arg Val Gly Gly 
                85                  90                  95      


Val Asp Val Leu Arg Ala Ala Gly Val Ala Thr Tyr Ala Ser Pro Ser 
            100                 105                 110         


Thr Arg Arg Leu Ala Glu Val Glu Gly Asn Glu Ile Pro Thr His Ser 
        115                 120                 125             


Leu Asp Gly Leu Ser Ser Ser Gly Asp Ala Val Arg Phe Gly Pro Val 
    130                 135                 140                 


Glu Leu Phe Tyr Pro Gly Ala Ala His Ser Thr Asp Asn Leu Val Val 
145                 150                 155                 160 


Tyr Val Pro Ser Ala Ser Val Leu Tyr Gly Gly Cys Ala Ile Tyr Glu 
                165                 170                 175     


Leu Ser Arg Thr Ser Ala Gly Asn Val Ala Asp Ala Asp Leu Ala Glu 
            180                 185                 190         


Trp Pro Thr Ser Ile Glu Arg Ile Gln Gln His Tyr Pro Glu Ala Gln 
        195                 200                 205             


Phe Val Ile Pro Gly His Gly Leu Pro Gly Gly Leu Asp Leu Leu Lys 
    210                 215                 220                 


His Thr Thr Asn Val Val Lys Ala His Thr Asn 
225                 230                 235 


<210>  46
<211>  235
<212>  PRT
<213>  artificial

<220>
<223>  VIM-2 V10A V1M Q34R E130D Q22H DCT236

<400>  46

Met Asp Ser Ser Gly Glu Tyr Pro Thr Ala Ser Glu Ile Pro Val Gly 
1               5                   10                  15      


Glu Val Arg Leu Tyr His Ile Ala Asp Gly Val Trp Ser His Ile Ala 
            20                  25                  30          


Thr Arg Ser Phe Asp Gly Ala Val Tyr Pro Ser Asn Gly Leu Ile Val 
        35                  40                  45              


Arg Asp Gly Asp Glu Leu Leu Leu Ile Asp Thr Ala Trp Gly Ala Lys 
    50                  55                  60                  


Asn Thr Ala Ala Leu Leu Ala Glu Ile Glu Lys Gln Ile Gly Leu Pro 
65                  70                  75                  80  


Val Thr Arg Ala Val Ser Thr His Phe His Asp Asp Arg Val Gly Gly 
                85                  90                  95      


Val Asp Val Leu Arg Ala Ala Gly Val Ala Thr Tyr Ala Ser Pro Ser 
            100                 105                 110         


Thr Arg Arg Leu Ala Glu Val Glu Gly Asn Glu Ile Pro Thr His Ser 
        115                 120                 125             


Leu Asp Gly Leu Ser Ser Ser Gly Asp Ala Val Arg Phe Gly Pro Val 
    130                 135                 140                 


Glu Leu Phe Tyr Pro Gly Ala Ala His Ser Thr Asp Asn Leu Val Val 
145                 150                 155                 160 


Tyr Val Pro Ser Ala Ser Val Leu Tyr Gly Gly Cys Ala Ile Tyr Glu 
                165                 170                 175     


Leu Ser Arg Thr Ser Ala Gly Asn Val Ala Asp Ala Asp Leu Ala Glu 
            180                 185                 190         


Trp Pro Thr Ser Ile Glu Arg Ile Gln Gln His Tyr Pro Glu Ala Gln 
        195                 200                 205             


Phe Val Ile Pro Gly His Gly Leu Pro Gly Gly Leu Asp Leu Leu Lys 
    210                 215                 220                 


His Thr Thr Asn Val Val Lys Ala His Thr Asn 
225                 230                 235 


<210>  47
<211>  263
<212>  PRT
<213>  artificial

<220>
<223>  P1A

<400>  47

Glu Met Lys Asp Asp Phe Ala Lys Leu Glu Glu Gln Phe Asp Ala Lys 
1               5                   10                  15      


Leu Gly Ile Phe Ala Leu Asp Thr Gly Thr Asn Arg Thr Val Ala Tyr 
            20                  25                  30          


Arg Pro Asp Glu Arg Phe Ala Phe Ala Ser Thr Ile Lys Ala Leu Thr 
        35                  40                  45              


Val Gly Val Leu Leu Gln Gln Lys Ser Ile Glu Asp Leu Asn Gln Arg 
    50                  55                  60                  


Ile Thr Tyr Thr Arg Asp Asp Leu Val Asn Tyr Asn Pro Ile Thr Glu 
65                  70                  75                  80  


Lys His Val Asp Thr Gly Met Thr Leu Lys Glu Leu Ala Asp Ala Ser 
                85                  90                  95      


Leu Arg Tyr Ser Asp Asn Ala Ala Gln Asn Leu Ile Leu Lys Gln Ile 
            100                 105                 110         


Gly Gly Pro Glu Ser Leu Lys Lys Glu Leu Arg Lys Ile Gly Asp Glu 
        115                 120                 125             


Val Thr Asn Pro Glu Arg Phe Glu Pro Glu Leu Asn Glu Val Asn Pro 
    130                 135                 140                 


Gly Glu Thr Gln Asp Thr Ser Thr Ala Arg Ala Leu Val Thr Ser Leu 
145                 150                 155                 160 


Arg Ala Phe Ala Leu Glu Asp Lys Leu Pro Ser Glu Lys Arg Glu Leu 
                165                 170                 175     


Leu Ile Asp Trp Met Lys Arg Asn Thr Thr Gly Asp Ala Leu Ile Arg 
            180                 185                 190         


Ala Gly Val Pro Asp Gly Trp Glu Val Ala Asp Lys Thr Gly Ala Ala 
        195                 200                 205             


Ser Tyr Gly Thr Arg Asn Asp Ile Ala Ile Ile Trp Pro Pro Lys Gly 
    210                 215                 220                 


Asp Pro Val Val Leu Ala Val Leu Ser Ser Arg Asp Lys Lys Asp Ala 
225                 230                 235                 240 


Lys Tyr Asp Asp Lys Leu Ile Ala Glu Ala Thr Lys Val Val Met Lys 
                245                 250                 255     


Ala Leu Asn Met Asn Gly Lys 
            260             


<210>  48
<211>  215
<212>  PRT
<213>  artificial

<220>
<223>  P2A

<400>  48

Glu Thr Gly Thr Ile Ser Ile Ser Gln Leu Asn Lys Asn Val Trp Val 
1               5                   10                  15      


His Thr Glu Leu Gly Tyr Phe Asn Gly Glu Ala Val Pro Ser Asn Gly 
            20                  25                  30          


Leu Val Leu Asn Thr Ser Lys Gly Leu Val Leu Val Asp Ser Ser Trp 
        35                  40                  45              


Asp Asn Lys Leu Thr Lys Glu Leu Ile Glu Met Val Glu Lys Lys Phe 
    50                  55                  60                  


Gln Lys Arg Val Thr Asp Val Ile Ile Thr His Ala His Ala Asp Arg 
65                  70                  75                  80  


Ile Gly Gly Ile Thr Ala Leu Lys Glu Arg Gly Ile Lys Ala His Ser 
                85                  90                  95      


Thr Ala Leu Thr Ala Glu Leu Ala Lys Asn Ser Gly Tyr Glu Glu Pro 
            100                 105                 110         


Leu Gly Asp Leu Gln Thr Ile Thr Ser Leu Lys Phe Gly Asn Thr Lys 
        115                 120                 125             


Val Glu Thr Phe Tyr Pro Gly Lys Gly His Thr Glu Asp Asn Ile Val 
    130                 135                 140                 


Val Trp Leu Pro Gln Tyr Gln Ile Leu Ala Gly Gly Cys Leu Val Lys 
145                 150                 155                 160 


Ser Ala Glu Ala Lys Asp Leu Gly Asn Val Ala Asp Ala Tyr Val Asn 
                165                 170                 175     


Glu Trp Ser Thr Ser Ile Glu Asn Val Leu Lys Arg Tyr Gly Asn Ile 
            180                 185                 190         


Asn Ser Trp Pro Gly His Gly Glu Val Gly Asp Lys Gly Leu Leu Leu 
        195                 200                 205             


His Thr Leu Asp Leu Leu Lys 
    210                 215 


<210>  49
<211>  258
<212>  PRT
<213>  artificial

<220>
<223>  P3A variants


<220>
<221>  MISC_FEATURE
<222>  (243)..(243)
<223>  Xaa can be any naturally occuring amino acid

<400>  49

Met Lys Asp Asp Phe Ala Lys Leu Glu Glu Gln Phe Asp Ala Lys Leu 
1               5                   10                  15      


Gly Ile Phe Ala Leu Asp Thr Gly Thr Asn Arg Thr Val Ala Tyr Arg 
            20                  25                  30          


Pro Asp Glu Arg Phe Ala Phe Ala Ser Thr Ile Lys Ala Leu Thr Val 
        35                  40                  45              


Gly Val Leu Leu Gln Gln Lys Ser Ile Glu Asp Leu Asn Gln Arg Ile 
    50                  55                  60                  


Thr Tyr Thr Arg Asp Asp Leu Val Asn Tyr Asn Pro Ile Thr Glu Lys 
65                  70                  75                  80  


His Val Asp Thr Gly Met Thr Leu Lys Glu Leu Ala Asp Ala Ser Leu 
                85                  90                  95      


Arg Tyr Ser Asp Asn Ala Ala Gln Asn Leu Ile Leu Lys Gln Ile Gly 
            100                 105                 110         


Gly Pro Glu Ser Leu Lys Lys Glu Leu Arg Lys Ile Gly Asp Glu Val 
        115                 120                 125             


Thr Asn Pro Glu Arg Phe Glu Pro Glu Leu Asn Glu Val Asn Pro Gly 
    130                 135                 140                 


Glu Thr Gln Asp Thr Ser Thr Ala Arg Ala Leu Val Thr Ser Leu Arg 
145                 150                 155                 160 


Ala Phe Ala Leu Glu Asp Lys Leu Pro Ser Glu Lys Arg Glu Leu Leu 
                165                 170                 175     


Ile Asp Trp Met Lys Arg Asn Thr Thr Gly Asp Ala Leu Ile Arg Ala 
            180                 185                 190         


Gly Val Pro Asp Gly Trp Glu Val Ala Asp Lys Thr Gly Ala Ala Ser 
        195                 200                 205             


Tyr Gly Thr Arg Asn Asp Ile Ala Ile Ile Trp Pro Pro Lys Gly Asp 
    210                 215                 220                 


Pro Val Val Leu Ala Val Leu Ser Ser Arg Asp Lys Lys Asp Ala Lys 
225                 230                 235                 240 


Tyr Asp Xaa Lys Leu Ile Ala Glu Ala Thr Lys Val Val Met Lys Ala 
                245                 250                 255     


Leu Asn 
        


<210>  50
<211>  299
<212>  PRT
<213>  artificial

<220>
<223>  P3A variants


<220>
<221>  misc_feature
<222>  (280)..(280)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  MISC_FEATURE
<222>  (290)..(290)
<223>  Xaa can be any naturally occuring amino acid

<400>  50

Met Ile Gln Lys Arg Lys Arg Thr Val Ser Phe Arg Leu Val Leu Met 
1               5                   10                  15      


Cys Thr Leu Leu Phe Val Ser Leu Pro Ile Thr Lys Thr Ser Ala Gln 
            20                  25                  30          


Ala Ser Lys Thr Glu Met Lys Asp Asp Phe Ala Lys Leu Glu Glu Gln 
        35                  40                  45              


Phe Asp Ala Lys Leu Gly Ile Phe Ala Leu Asp Thr Gly Thr Asn Arg 
    50                  55                  60                  


Thr Val Ala Tyr Arg Pro Asp Glu Arg Phe Ala Phe Ala Ser Thr Ile 
65                  70                  75                  80  


Lys Ala Leu Thr Val Gly Val Leu Leu Gln Gln Lys Ser Ile Glu Asp 
                85                  90                  95      


Leu Asn Gln Arg Ile Thr Tyr Thr Arg Asp Asp Leu Val Asn Tyr Asn 
            100                 105                 110         


Pro Ile Thr Glu Lys His Val Asp Thr Gly Met Thr Leu Lys Glu Leu 
        115                 120                 125             


Ala Asp Ala Ser Leu Arg Tyr Ser Asp Asn Ala Ala Gln Asn Leu Ile 
    130                 135                 140                 


Leu Lys Gln Ile Gly Gly Pro Glu Ser Leu Lys Lys Glu Leu Arg Lys 
145                 150                 155                 160 


Ile Gly Asp Glu Val Thr Asn Pro Glu Arg Phe Glu Pro Glu Leu Asn 
                165                 170                 175     


Glu Val Asn Pro Gly Glu Thr Gln Asp Thr Ser Thr Ala Arg Ala Leu 
            180                 185                 190         


Val Thr Ser Leu Arg Ala Phe Ala Leu Glu Asp Lys Leu Pro Ser Glu 
        195                 200                 205             


Lys Arg Glu Leu Leu Ile Asp Trp Met Lys Arg Asn Thr Thr Gly Asp 
    210                 215                 220                 


Ala Leu Ile Arg Ala Gly Val Pro Asp Gly Trp Glu Val Ala Asp Lys 
225                 230                 235                 240 


Thr Gly Ala Ala Ser Tyr Gly Thr Arg Asn Asp Ile Ala Ile Ile Trp 
                245                 250                 255     


Pro Pro Lys Gly Asp Pro Val Val Leu Ala Val Leu Ser Ser Arg Asp 
            260                 265                 270         


Lys Lys Asp Ala Lys Tyr Asp Xaa Lys Leu Ile Ala Glu Ala Thr Lys 
        275                 280                 285             


Val Val Met Lys Ala Leu Asn Met Asn Gly Lys 
    290                 295                 


<210>  51
<211>  293
<212>  PRT
<213>  artificial

<220>
<223>  KPC-1/2

<400>  51

Met Ser Leu Tyr Arg Arg Leu Val Leu Leu Ser Cys Leu Ser Trp Pro 
1               5                   10                  15      


Leu Ala Gly Phe Ser Ala Thr Ala Leu Thr Asn Leu Val Ala Glu Pro 
            20                  25                  30          


Phe Ala Lys Leu Glu Gln Asp Phe Gly Gly Ser Ile Gly Val Tyr Ala 
        35                  40                  45              


Met Asp Thr Gly Ser Gly Ala Thr Val Ser Tyr Arg Ala Glu Glu Arg 
    50                  55                  60                  


Phe Pro Leu Cys Ser Ser Phe Lys Gly Phe Leu Ala Ala Ala Val Leu 
65                  70                  75                  80  


Ala Arg Ser Gln Gln Gln Ala Gly Leu Leu Asp Thr Pro Ile Arg Tyr 
                85                  90                  95      


Gly Lys Asn Ala Leu Val Pro Trp Ser Pro Ile Ser Glu Lys Tyr Leu 
            100                 105                 110         


Thr Thr Gly Met Thr Val Ala Glu Leu Ser Ala Ala Ala Val Gln Tyr 
        115                 120                 125             


Ser Asp Asn Ala Ala Ala Asn Leu Leu Leu Lys Glu Leu Gly Gly Pro 
    130                 135                 140                 


Ala Gly Leu Thr Ala Phe Met Arg Ser Ile Gly Asp Thr Thr Phe Arg 
145                 150                 155                 160 


Leu Asp Arg Trp Glu Leu Glu Leu Asn Ser Ala Ile Pro Ser Asp Ala 
                165                 170                 175     


Arg Asp Thr Ser Ser Pro Arg Ala Val Thr Glu Ser Leu Gln Lys Leu 
            180                 185                 190         


Thr Leu Gly Ser Ala Leu Ala Ala Pro Gln Arg Gln Gln Phe Val Asp 
        195                 200                 205             


Trp Leu Lys Gly Asn Thr Thr Gly Asn His Arg Ile Arg Ala Ala Val 
    210                 215                 220                 


Pro Ala Asp Trp Ala Val Gly Asp Lys Thr Gly Thr Cys Gly Val Tyr 
225                 230                 235                 240 


Gly Thr Ala Asn Asp Tyr Ala Val Val Trp Pro Thr Gly Arg Ala Pro 
                245                 250                 255     


Ile Val Leu Ala Val Tyr Thr Arg Ala Pro Asn Lys Asp Asp Lys His 
            260                 265                 270         


Ser Glu Ala Val Ile Ala Ala Ala Ala Arg Leu Ala Leu Glu Gly Leu 
        275                 280                 285             


Gly Val Asn Gly Gln 
    290             


<210>  52
<211>  293
<212>  PRT
<213>  artificial

<220>
<223>  KPC-3

<400>  52

Met Ser Leu Tyr Arg Arg Leu Val Leu Leu Ser Cys Leu Ser Trp Pro 
1               5                   10                  15      


Leu Ala Gly Phe Ser Ala Thr Ala Leu Thr Asn Leu Val Ala Glu Pro 
            20                  25                  30          


Phe Ala Lys Leu Glu Gln Asp Phe Gly Gly Ser Ile Gly Val Tyr Ala 
        35                  40                  45              


Met Asp Thr Gly Ser Gly Ala Thr Val Ser Tyr Arg Ala Glu Glu Arg 
    50                  55                  60                  


Phe Pro Leu Cys Ser Ser Phe Lys Gly Phe Leu Ala Ala Ala Val Leu 
65                  70                  75                  80  


Ala Arg Ser Gln Gln Gln Ala Gly Leu Leu Asp Thr Pro Ile Arg Tyr 
                85                  90                  95      


Gly Lys Asn Ala Leu Val Pro Trp Ser Pro Ile Ser Glu Lys Tyr Leu 
            100                 105                 110         


Thr Thr Gly Met Thr Val Ala Glu Leu Ser Ala Ala Ala Val Gln Tyr 
        115                 120                 125             


Ser Asp Asn Ala Ala Ala Asn Leu Leu Leu Lys Glu Leu Gly Gly Pro 
    130                 135                 140                 


Ala Gly Leu Thr Ala Phe Met Arg Ser Ile Gly Asp Thr Thr Phe Arg 
145                 150                 155                 160 


Leu Asp Arg Trp Glu Leu Glu Leu Asn Ser Ala Ile Pro Gly Asp Ala 
                165                 170                 175     


Arg Asp Thr Ser Ser Pro Arg Ala Val Thr Glu Ser Leu Gln Lys Leu 
            180                 185                 190         


Thr Leu Gly Ser Ala Leu Ala Ala Pro Gln Arg Gln Gln Phe Val Asp 
        195                 200                 205             


Trp Leu Lys Gly Asn Thr Thr Gly Asn His Arg Ile Arg Ala Ala Val 
    210                 215                 220                 


Pro Ala Asp Trp Ala Val Gly Asp Lys Thr Gly Thr Cys Gly Val Tyr 
225                 230                 235                 240 


Gly Thr Ala Asn Asp Tyr Ala Val Val Trp Pro Thr Gly Arg Ala Pro 
                245                 250                 255     


Ile Val Leu Ala Val Tyr Thr Arg Ala Pro Asn Lys Asp Asp Lys Tyr 
            260                 265                 270         


Ser Glu Ala Val Ile Ala Ala Ala Ala Arg Leu Ala Leu Glu Gly Leu 
        275                 280                 285             


Gly Val Asn Gly Gln 
    290             


<210>  53
<211>  292
<212>  PRT
<213>  artificial

<220>
<223>  KPC-4

<400>  53

Met Ser Leu Tyr Arg Arg Leu Val Leu Leu Ser Cys Leu Ser Trp Pro 
1               5                   10                  15      


Leu Ala Gly Phe Ser Ala Thr Ala Leu Thr Asn Leu Val Ala Glu Pro 
            20                  25                  30          


Phe Ala Lys Leu Glu Gln Asp Phe Gly Gly Ser Ile Gly Val Tyr Ala 
        35                  40                  45              


Met Asp Thr Gly Ser Gly Ala Thr Val Ser Tyr Arg Ala Glu Glu Arg 
    50                  55                  60                  


Phe Pro Leu Cys Ser Ser Phe Lys Gly Phe Leu Ala Ala Ala Val Leu 
65                  70                  75                  80  


Ala Arg Ser Gln Gln Gln Ala Gly Leu Leu Asp Thr Pro Ile Arg Tyr 
                85                  90                  95      


Gly Lys Asn Ala Leu Val Arg Trp Ser Pro Ile Ser Glu Lys Tyr Leu 
            100                 105                 110         


Thr Thr Gly Met Thr Val Ala Glu Leu Ser Ala Ala Ala Val Gln Tyr 
        115                 120                 125             


Ser Asp Asn Ala Ala Ala Asn Leu Leu Leu Lys Glu Leu Gly Gly Pro 
    130                 135                 140                 


Ala Gly Leu Thr Ala Phe Met Arg Ser Ile Gly Asp Thr Thr Phe Arg 
145                 150                 155                 160 


Leu Asp Arg Trp Glu Leu Glu Leu Asn Ser Ala Ile Pro Gly Asp Ala 
                165                 170                 175     


Arg Asp Thr Ser Ser Pro Arg Ala Val Thr Glu Ser Leu Gln Lys Leu 
            180                 185                 190         


Thr Leu Gly Ser Ala Leu Ala Ala Pro Gln Arg Gln Gln Phe Val Asp 
        195                 200                 205             


Trp Leu Lys Gly Asn Thr Thr Gly Asn His Arg Ile Arg Ala Ala Val 
    210                 215                 220                 


Pro Ala Asp Trp Ala Val Gly Asp Lys Thr Gly Thr Cys Gly Gly Tyr 
225                 230                 235                 240 


Gly Thr Ala Asn Asp Tyr Ala Trp Trp Pro Thr Gly Arg Ala Pro Ile 
                245                 250                 255     


Val Leu Ala Val Tyr Thr Arg Ala Pro Asn Lys Asp Asp Lys His Ser 
            260                 265                 270         


Glu Ala Val Ile Ala Ala Ala Ala Arg Leu Ala Leu Glu Gly Leu Gly 
        275                 280                 285             


Val Asn Gly Gln 
    290         


<210>  54
<211>  293
<212>  PRT
<213>  artificial

<220>
<223>  KPC-5

<400>  54

Met Ser Leu Tyr Arg Arg Leu Val Leu Leu Ser Cys Leu Ser Trp Pro 
1               5                   10                  15      


Leu Ala Gly Phe Ser Ala Thr Ala Leu Thr Asn Leu Val Ala Glu Pro 
            20                  25                  30          


Phe Ala Lys Leu Glu Gln Asp Phe Gly Gly Ser Ile Gly Val Tyr Ala 
        35                  40                  45              


Met Asp Thr Gly Ser Gly Ala Thr Val Ser Tyr Arg Ala Glu Glu Arg 
    50                  55                  60                  


Phe Pro Leu Cys Ser Ser Phe Lys Gly Phe Leu Ala Ala Ala Val Leu 
65                  70                  75                  80  


Ala Arg Ser Gln Gln Gln Ala Gly Leu Leu Asp Thr Pro Ile Arg Tyr 
                85                  90                  95      


Gly Lys Asn Ala Leu Val Arg Trp Ser Pro Ile Ser Glu Lys Tyr Leu 
            100                 105                 110         


Thr Thr Gly Met Thr Val Ala Glu Leu Ser Ala Ala Ala Val Gln Tyr 
        115                 120                 125             


Ser Asp Asn Ala Ala Ala Asn Leu Leu Leu Lys Glu Leu Gly Gly Pro 
    130                 135                 140                 


Ala Gly Leu Thr Ala Phe Met Arg Ser Ile Gly Asp Thr Thr Phe Arg 
145                 150                 155                 160 


Leu Asp Arg Trp Glu Leu Glu Leu Asn Ser Ala Ile Pro Gly Asp Ala 
                165                 170                 175     


Arg Asp Thr Ser Ser Pro Arg Ala Val Thr Glu Ser Leu Gln Lys Leu 
            180                 185                 190         


Thr Leu Gly Ser Ala Leu Ala Ala Pro Gln Arg Gln Gln Phe Val Asp 
        195                 200                 205             


Trp Leu Lys Gly Asn Thr Thr Gly Asn His Arg Ile Arg Ala Ala Val 
    210                 215                 220                 


Pro Ala Asp Trp Ala Val Gly Asp Lys Thr Gly Thr Cys Gly Val Tyr 
225                 230                 235                 240 


Gly Thr Ala Asn Asp Tyr Ala Val Val Trp Pro Thr Gly Arg Ala Pro 
                245                 250                 255     


Ile Val Leu Ala Val Tyr Thr Arg Ala Pro Asn Lys Asp Asp Lys His 
            260                 265                 270         


Ser Glu Ala Val Ile Ala Ala Ala Ala Arg Leu Ala Leu Glu Gly Leu 
        275                 280                 285             


Gly Val Asn Gly Gln 
    290             


<210>  55
<211>  292
<212>  PRT
<213>  artificial

<220>
<223>  KPC-6

<400>  55

Met Ser Leu Tyr Arg Arg Leu Val Leu Leu Ser Cys Leu Ser Trp Pro 
1               5                   10                  15      


Leu Ala Gly Phe Ser Ala Thr Ala Leu Thr Asn Leu Val Ala Glu Pro 
            20                  25                  30          


Phe Ala Lys Leu Glu Gln Asp Phe Gly Gly Ser Ile Gly Val Tyr Ala 
        35                  40                  45              


Met Asp Thr Gly Ser Gly Ala Thr Val Ser Tyr Arg Ala Glu Glu Arg 
    50                  55                  60                  


Phe Pro Leu Cys Ser Ser Phe Lys Gly Phe Leu Ala Ala Ala Val Leu 
65                  70                  75                  80  


Ala Arg Ser Gln Gln Gln Ala Gly Leu Leu Asp Thr Pro Ile Arg Tyr 
                85                  90                  95      


Gly Lys Asn Ala Leu Val Pro Trp Ser Pro Ile Ser Glu Lys Tyr Leu 
            100                 105                 110         


Thr Thr Gly Met Thr Val Ala Glu Leu Ser Ala Ala Ala Val Gln Tyr 
        115                 120                 125             


Ser Asp Asn Ala Ala Ala Asn Leu Leu Leu Lys Glu Leu Gly Gly Pro 
    130                 135                 140                 


Ala Gly Leu Thr Ala Phe Met Arg Ser Ile Gly Asp Thr Thr Phe Arg 
145                 150                 155                 160 


Leu Asp Arg Trp Glu Leu Glu Leu Asn Ser Ala Ile Pro Gly Asp Ala 
                165                 170                 175     


Arg Asp Thr Ser Ser Pro Arg Ala Val Thr Glu Ser Leu Gln Lys Leu 
            180                 185                 190         


Thr Leu Gly Ser Ala Leu Ala Ala Pro Gln Arg Gln Gln Phe Val Asp 
        195                 200                 205             


Trp Leu Lys Gly Asn Thr Thr Gly Asn His Arg Ile Arg Ala Ala Val 
    210                 215                 220                 


Pro Ala Asp Trp Ala Val Gly Asp Lys Thr Gly Thr Cys Gly Gly Tyr 
225                 230                 235                 240 


Gly Thr Ala Asn Asp Tyr Ala Trp Trp Pro Thr Gly Arg Ala Pro Ile 
                245                 250                 255     


Val Leu Ala Val Tyr Thr Arg Ala Pro Asn Lys Asp Asp Lys His Ser 
            260                 265                 270         


Glu Ala Val Ile Ala Ala Ala Ala Arg Leu Ala Leu Glu Gly Leu Gly 
        275                 280                 285             


Val Asn Gly Gln 
    290         


<210>  56
<211>  293
<212>  PRT
<213>  artificial

<220>
<223>  KPC-7

<400>  56

Met Ser Leu Tyr Arg Arg Leu Val Leu Leu Ser Cys Leu Ser Trp Pro 
1               5                   10                  15      


Leu Ala Gly Phe Ser Ala Thr Ala Leu Thr Asn Leu Val Ala Glu Pro 
            20                  25                  30          


Phe Ala Lys Leu Glu Gln Asp Phe Gly Gly Ser Ile Gly Val Tyr Ala 
        35                  40                  45              


Ile Asp Thr Gly Ser Gly Ala Thr Val Ser Tyr Arg Ala Glu Glu Arg 
    50                  55                  60                  


Phe Pro Leu Cys Ser Ser Phe Lys Gly Phe Leu Ala Ala Ala Val Leu 
65                  70                  75                  80  


Ala Arg Ser Gln Gln Gln Ala Gly Leu Leu Asp Thr Pro Ile Arg Tyr 
                85                  90                  95      


Gly Lys Asn Ala Leu Val Pro Trp Ser Pro Ile Ser Glu Lys Tyr Leu 
            100                 105                 110         


Thr Thr Gly Met Thr Val Ala Glu Leu Ser Ala Ala Ala Val Gln Tyr 
        115                 120                 125             


Ser Asp Asn Ala Ala Ala Asn Leu Leu Leu Lys Glu Leu Gly Gly Pro 
    130                 135                 140                 


Ala Gly Leu Thr Ala Phe Met Arg Ser Ile Gly Asp Thr Thr Phe Arg 
145                 150                 155                 160 


Leu Asp Arg Trp Glu Leu Glu Leu Asn Ser Ala Ile Pro Gly Asp Ala 
                165                 170                 175     


Arg Asp Thr Ser Ser Pro Arg Ala Val Thr Glu Ser Leu Gln Lys Leu 
            180                 185                 190         


Thr Leu Gly Ser Ala Leu Ala Ala Pro Gln Arg Gln Gln Phe Val Asp 
        195                 200                 205             


Trp Leu Lys Gly Asn Thr Thr Gly Asn His Arg Leu Arg Ala Ala Val 
    210                 215                 220                 


Pro Ala Asp Trp Ala Val Gly Asp Lys Thr Gly Thr Cys Gly Val Tyr 
225                 230                 235                 240 


Gly Thr Ala Asn Asp Tyr Ala Val Val Trp Pro Thr Gly Arg Ala Pro 
                245                 250                 255     


Ile Val Leu Ala Val Tyr Thr Arg Ala Pro Asn Lys Asp Asp Lys Tyr 
            260                 265                 270         


Ser Glu Ala Val Ile Ala Ala Ala Ala Arg Leu Ala Leu Glu Gly Leu 
        275                 280                 285             


Gly Val Asn Gly Gln 
    290             


<210>  57
<211>  292
<212>  PRT
<213>  artificial

<220>
<223>  KPC-8

<400>  57

Met Ser Leu Tyr Arg Arg Leu Val Leu Leu Ser Cys Leu Ser Trp Pro 
1               5                   10                  15      


Leu Ala Gly Phe Ser Ala Thr Ala Leu Thr Asn Leu Val Ala Glu Pro 
            20                  25                  30          


Phe Ala Lys Leu Glu Gln Asp Phe Gly Gly Ser Ile Gly Val Tyr Ala 
        35                  40                  45              


Met Asp Thr Gly Ser Gly Ala Thr Val Ser Tyr Arg Ala Glu Glu Arg 
    50                  55                  60                  


Phe Pro Leu Cys Ser Ser Phe Lys Gly Phe Leu Ala Ala Ala Val Leu 
65                  70                  75                  80  


Ala Arg Ser Gln Gln Gln Ala Gly Leu Leu Asp Thr Pro Ile Arg Tyr 
                85                  90                  95      


Gly Lys Asn Ala Leu Val Pro Trp Ser Pro Ile Ser Glu Lys Tyr Leu 
            100                 105                 110         


Thr Thr Gly Met Thr Val Ala Glu Leu Ser Ala Ala Ala Val Gln Tyr 
        115                 120                 125             


Ser Asp Asn Ala Ala Ala Asn Leu Leu Leu Lys Glu Leu Gly Gly Pro 
    130                 135                 140                 


Ala Gly Leu Thr Ala Phe Met Arg Ser Ile Gly Asp Thr Thr Phe Arg 
145                 150                 155                 160 


Leu Asp Arg Trp Glu Leu Glu Leu Asn Ser Ala Ile Pro Gly Asp Ala 
                165                 170                 175     


Arg Asp Thr Ser Ser Pro Arg Ala Val Thr Glu Ser Leu Gln Lys Leu 
            180                 185                 190         


Thr Leu Gly Ser Ala Leu Ala Ala Pro Gln Arg Gln Gln Phe Val Asp 
        195                 200                 205             


Trp Leu Lys Gly Asn Thr Thr Gly Asn His Arg Ile Arg Ala Ala Val 
    210                 215                 220                 


Pro Ala Asp Trp Ala Val Gly Asp Lys Thr Gly Thr Cys Gly Gly Tyr 
225                 230                 235                 240 


Gly Thr Ala Asn Asp Tyr Ala Trp Trp Pro Thr Gly Arg Ala Pro Ile 
                245                 250                 255     


Val Leu Ala Val Tyr Thr Arg Ala Pro Asn Lys Asp Asp Lys Tyr Ser 
            260                 265                 270         


Glu Ala Val Ile Ala Ala Ala Ala Arg Leu Ala Leu Glu Gly Leu Gly 
        275                 280                 285             


Val Asn Gly Gln 
    290         


<210>  58
<211>  293
<212>  PRT
<213>  artificial

<220>
<223>  KPC-9

<400>  58

Met Ser Lys Tyr Arg Arg Leu Val Leu Leu Ser Cys Leu Ser Trp Pro 
1               5                   10                  15      


Leu Ala Gly Phe Ser Ala Thr Ala Leu Thr Asn Leu Val Ala Glu Pro 
            20                  25                  30          


Phe Ala Lys Leu Glu Gln Asp Phe Gly Gly Ser Ile Gly Val Tyr Ala 
        35                  40                  45              


Met Asp Thr Gly Ser Gly Ala Thr Val Ser Tyr Arg Ala Glu Glu Arg 
    50                  55                  60                  


Phe Pro Leu Cys Ser Ser Phe Lys Gly Phe Leu Ala Ala Ala Val Leu 
65                  70                  75                  80  


Ala Arg Ser Gln Gln Gln Ala Gly Leu Leu Asp Thr Pro Ile Arg Tyr 
                85                  90                  95      


Gly Lys Asn Ala Leu Val Pro Trp Ser Pro Ile Ser Glu Lys Tyr Leu 
            100                 105                 110         


Thr Thr Gly Met Thr Val Ala Glu Leu Ser Ala Ala Ala Val Gln Tyr 
        115                 120                 125             


Ser Asp Asn Ala Ala Ala Asn Leu Leu Leu Lys Glu Leu Gly Gly Pro 
    130                 135                 140                 


Ala Gly Leu Thr Ala Phe Met Arg Ser Ile Gly Asp Thr Thr Phe Arg 
145                 150                 155                 160 


Leu Asp Arg Trp Glu Leu Glu Leu Asn Ser Ala Ile Pro Gly Asp Ala 
                165                 170                 175     


Arg Asp Thr Ser Ser Pro Arg Ala Val Thr Glu Ser Leu Gln Lys Leu 
            180                 185                 190         


Thr Leu Gly Ser Ala Leu Ala Ala Pro Gln Arg Gln Gln Phe Val Asp 
        195                 200                 205             


Trp Leu Lys Gly Asn Thr Thr Gly Asn His Arg Ile Arg Ala Ala Val 
    210                 215                 220                 


Pro Ala Asp Trp Ala Val Gly Asp Lys Thr Gly Thr Cys Gly Ala Tyr 
225                 230                 235                 240 


Gly Thr Ala Asn Asp Tyr Ala Val Val Trp Pro Thr Gly Arg Ala Pro 
                245                 250                 255     


Ile Val Leu Ala Val Tyr Thr Arg Ala Pro Asn Lys Asp Asp Lys Tyr 
            260                 265                 270         


Ser Glu Ala Val Ile Ala Ala Ala Ala Arg Leu Ala Leu Glu Gly Leu 
        275                 280                 285             


Gly Val Asn Gly Gln 
    290             


<210>  59
<211>  293
<212>  PRT
<213>  artificial

<220>
<223>  KPC-10

<400>  59

Met Ser Leu Tyr Arg Arg Leu Val Leu Leu Ser Cys Leu Ser Trp Pro 
1               5                   10                  15      


Leu Ala Gly Phe Ser Ala Thr Ala Leu Thr Asn Leu Val Ala Glu Pro 
            20                  25                  30          


Phe Ala Lys Leu Glu Gln Asp Phe Gly Gly Ser Ile Gly Val Tyr Ala 
        35                  40                  45              


Met Asp Thr Gly Ser Gly Ala Thr Val Ser Tyr Arg Ala Glu Glu Arg 
    50                  55                  60                  


Phe Pro Leu Cys Ser Ser Phe Lys Gly Phe Leu Ala Ala Ala Val Leu 
65                  70                  75                  80  


Ala Arg Ser Gln Gln Gln Ala Gly Leu Leu Asp Thr Pro Ile Arg Tyr 
                85                  90                  95      


Gly Lys Asn Ala Leu Val Arg Trp Ser Pro Ile Ser Glu Lys Tyr Leu 
            100                 105                 110         


Thr Thr Gly Met Thr Val Ala Glu Leu Ser Ala Ala Ala Val Gln Tyr 
        115                 120                 125             


Ser Asp Asn Ala Ala Ala Asn Leu Leu Leu Lys Glu Leu Gly Gly Pro 
    130                 135                 140                 


Ala Gly Leu Thr Ala Phe Met Arg Ser Ile Gly Asp Thr Thr Phe Arg 
145                 150                 155                 160 


Leu Asp Arg Trp Glu Leu Glu Leu Asn Ser Ala Ile Pro Gly Asp Ala 
                165                 170                 175     


Arg Asp Thr Ser Ser Pro Arg Ala Val Thr Glu Ser Leu Gln Lys Leu 
            180                 185                 190         


Thr Leu Gly Ser Ala Leu Ala Ala Pro Gln Arg Gln Gln Phe Val Asp 
        195                 200                 205             


Trp Leu Lys Gly Asn Thr Thr Gly Asn His Arg Ile Arg Ala Ala Val 
    210                 215                 220                 


Pro Ala Asp Trp Ala Val Gly Asp Lys Thr Gly Thr Cys Gly Val Tyr 
225                 230                 235                 240 


Gly Thr Ala Asn Asp Tyr Ala Val Val Trp Pro Thr Gly Arg Ala Pro 
                245                 250                 255     


Ile Val Leu Ala Val Tyr Thr Arg Ala Pro Asn Lys Asp Asp Lys Tyr 
            260                 265                 270         


Ser Glu Ala Val Ile Ala Ala Ala Ala Arg Leu Ala Leu Glu Gly Leu 
        275                 280                 285             


Gly Val Asn Gly Gln 
    290             


<210>  60
<211>  293
<212>  PRT
<213>  artificial

<220>
<223>  KPC-11

<400>  60

Met Ser Leu Tyr Arg Arg Leu Val Leu Leu Ser Cys Leu Ser Trp Pro 
1               5                   10                  15      


Leu Ala Gly Phe Ser Ala Thr Ala Leu Thr Asn Leu Val Ala Glu Pro 
            20                  25                  30          


Phe Ala Lys Leu Glu Gln Asp Phe Gly Gly Ser Ile Gly Val Tyr Ala 
        35                  40                  45              


Met Asp Thr Gly Ser Gly Ala Thr Val Ser Tyr Arg Ala Glu Glu Arg 
    50                  55                  60                  


Phe Pro Leu Cys Ser Ser Phe Lys Gly Phe Leu Ala Ala Ala Val Leu 
65                  70                  75                  80  


Ala Arg Ser Gln Gln Gln Ala Gly Leu Leu Asp Thr Pro Ile Arg Tyr 
                85                  90                  95      


Gly Lys Asn Ala Leu Val Leu Trp Ser Pro Ile Ser Glu Lys Tyr Leu 
            100                 105                 110         


Thr Thr Gly Met Thr Val Ala Glu Leu Ser Ala Ala Ala Val Gln Tyr 
        115                 120                 125             


Ser Asp Asn Ala Ala Ala Asn Leu Leu Leu Lys Glu Leu Gly Gly Pro 
    130                 135                 140                 


Ala Gly Leu Thr Ala Phe Met Arg Ser Ile Gly Asp Thr Thr Phe Arg 
145                 150                 155                 160 


Leu Asp Arg Trp Glu Leu Glu Leu Asn Ser Ala Ile Pro Gly Asp Ala 
                165                 170                 175     


Arg Asp Thr Ser Ser Pro Arg Ala Val Thr Glu Ser Leu Gln Lys Leu 
            180                 185                 190         


Thr Leu Gly Ser Ala Leu Ala Ala Pro Gln Arg Gln Gln Phe Val Asp 
        195                 200                 205             


Trp Leu Lys Gly Asn Thr Thr Gly Asn His Arg Ile Arg Ala Ala Val 
    210                 215                 220                 


Pro Ala Asp Trp Ala Val Gly Asp Lys Thr Gly Thr Cys Gly Val Tyr 
225                 230                 235                 240 


Gly Thr Ala Asn Asp Tyr Ala Val Val Trp Pro Thr Gly Arg Ala Pro 
                245                 250                 255     


Ile Val Leu Ala Val Tyr Thr Arg Ala Pro Asn Lys Asp Asp Lys His 
            260                 265                 270         


Ser Glu Ala Val Ile Ala Ala Ala Ala Arg Leu Ala Leu Glu Gly Leu 
        275                 280                 285             


Gly Val Asn Gly Gln 
    290             


<210>  61
<211>  293
<212>  PRT
<213>  artificial

<220>
<223>  KPC-12

<400>  61

Met Ser Leu Tyr Arg Arg Leu Val Leu Leu Ser Cys Leu Ser Trp Pro 
1               5                   10                  15      


Leu Ala Gly Phe Ser Ala Thr Ala Leu Thr Asn Leu Val Ala Glu Pro 
            20                  25                  30          


Phe Ala Lys Leu Glu Gln Asp Phe Gly Gly Ser Ile Gly Val Tyr Ala 
        35                  40                  45              


Met Asp Thr Gly Ser Gly Ala Thr Val Ser Tyr Arg Ala Glu Glu Arg 
    50                  55                  60                  


Phe Pro Leu Cys Ser Ser Phe Lys Gly Phe Leu Ala Ala Ala Val Leu 
65                  70                  75                  80  


Ala Arg Ser Gln Gln Gln Ala Gly Leu Leu Asp Thr Pro Ile Arg Tyr 
                85                  90                  95      


Gly Lys Asn Ala Leu Val Pro Trp Ser Pro Ile Ser Glu Lys Tyr Leu 
            100                 105                 110         


Thr Thr Gly Met Thr Val Ala Glu Leu Ser Ala Ala Ala Val Gln Tyr 
        115                 120                 125             


Ser Asp Asn Ala Ala Ala Asn Leu Leu Leu Lys Glu Leu Gly Gly Pro 
    130                 135                 140                 


Ala Gly Leu Thr Ala Phe Met Arg Ser Ile Gly Asp Thr Thr Phe Arg 
145                 150                 155                 160 


Leu Asp Arg Trp Glu Leu Glu Met Asn Ser Ala Ile Pro Gly Asp Ala 
                165                 170                 175     


Arg Asp Thr Ser Ser Pro Arg Ala Val Thr Glu Ser Leu Gln Lys Leu 
            180                 185                 190         


Thr Leu Gly Ser Ala Leu Ala Ala Pro Gln Arg Gln Gln Phe Val Asp 
        195                 200                 205             


Trp Leu Lys Gly Asn Thr Thr Gly Asn His Arg Ile Arg Ala Ala Val 
    210                 215                 220                 


Pro Ala Asp Trp Ala Val Gly Asp Lys Thr Gly Thr Cys Gly Val Tyr 
225                 230                 235                 240 


Gly Thr Ala Asn Asp Tyr Ala Val Val Trp Pro Thr Gly Arg Ala Pro 
                245                 250                 255     


Ile Val Leu Ala Val Tyr Thr Arg Ala Pro Asn Lys Asp Asp Lys His 
            260                 265                 270         


Ser Glu Ala Val Ile Ala Ala Ala Ala Arg Leu Ala Leu Glu Gly Leu 
        275                 280                 285             


Gly Val Asn Gly Gln 
    290             


<210>  62
<211>  293
<212>  PRT
<213>  artificial

<220>
<223>  KPC-13

<400>  62

Met Ser Leu Tyr Arg Arg Leu Val Leu Leu Ser Cys Leu Ser Trp Pro 
1               5                   10                  15      


Leu Ala Gly Phe Ser Ala Thr Ala Leu Thr Asn Leu Val Ala Glu Pro 
            20                  25                  30          


Phe Ala Lys Leu Glu Gln Asp Phe Gly Gly Ser Ile Gly Val Tyr Ala 
        35                  40                  45              


Met Asp Thr Gly Ser Gly Ala Thr Val Ser Tyr Arg Ala Glu Glu Arg 
    50                  55                  60                  


Phe Pro Leu Cys Ser Ser Phe Lys Gly Phe Leu Ala Ala Ala Val Leu 
65                  70                  75                  80  


Ala Arg Ser Gln Gln Gln Ala Gly Leu Leu Gly Thr Pro Ile Arg Tyr 
                85                  90                  95      


Gly Lys Asn Ala Leu Val Pro Trp Ser Pro Ile Ser Glu Lys Tyr Leu 
            100                 105                 110         


Thr Thr Gly Met Thr Val Ala Glu Leu Ser Ala Ala Ala Val Gln Tyr 
        115                 120                 125             


Ser Asp Asn Ala Ala Ala Asn Leu Leu Leu Lys Glu Leu Gly Gly Pro 
    130                 135                 140                 


Ala Gly Leu Thr Ala Phe Met Arg Ser Ile Gly Asp Thr Thr Phe Arg 
145                 150                 155                 160 


Leu Asp Arg Trp Glu Leu Glu Leu Asn Ser Ala Ile Pro Gly Asp Ala 
                165                 170                 175     


Arg Asp Thr Ser Ser Pro Arg Ala Val Thr Glu Ser Leu Gln Lys Leu 
            180                 185                 190         


Thr Leu Gly Ser Ala Leu Ala Ala Pro Gln Arg Gln Gln Phe Val Asp 
        195                 200                 205             


Trp Leu Lys Gly Asn Thr Thr Gly Asn His Arg Ile Arg Ala Ala Val 
    210                 215                 220                 


Pro Ala Asp Trp Ala Val Gly Asp Lys Thr Gly Thr Cys Gly Val Tyr 
225                 230                 235                 240 


Gly Thr Ala Asn Asp Tyr Ala Val Val Trp Pro Thr Gly Arg Ala Pro 
                245                 250                 255     


Ile Val Leu Ala Val Tyr Thr Arg Ala Pro Asn Lys Asp Asp Lys Tyr 
            260                 265                 270         


Ser Glu Ala Val Ile Ala Ala Ala Ala Arg Leu Ala Leu Glu Gly Leu 
        275                 280                 285             


Gly Val Asn Gly Gln 
    290             


<210>  63
<211>  291
<212>  PRT
<213>  artificial

<220>
<223>  KPC-14

<400>  63

Met Ser Leu Tyr Arg Arg Leu Val Leu Leu Ser Cys Leu Ser Trp Pro 
1               5                   10                  15      


Leu Ala Gly Phe Ser Ala Thr Ala Leu Thr Asn Leu Val Ala Glu Pro 
            20                  25                  30          


Phe Ala Lys Leu Glu Gln Asp Phe Gly Gly Ser Ile Gly Val Tyr Ala 
        35                  40                  45              


Met Asp Thr Gly Ser Gly Ala Thr Val Ser Tyr Arg Ala Glu Glu Arg 
    50                  55                  60                  


Phe Pro Leu Cys Ser Ser Phe Lys Gly Phe Leu Ala Ala Ala Val Leu 
65                  70                  75                  80  


Ala Arg Ser Gln Gln Gln Ala Gly Leu Leu Asp Thr Pro Ile Arg Tyr 
                85                  90                  95      


Gly Lys Asn Ala Leu Val Pro Trp Ser Pro Ile Ser Glu Lys Tyr Leu 
            100                 105                 110         


Thr Thr Gly Met Thr Val Ala Glu Leu Ser Ala Ala Ala Val Gln Tyr 
        115                 120                 125             


Ser Asp Asn Ala Ala Ala Asn Leu Leu Leu Lys Glu Leu Gly Gly Pro 
    130                 135                 140                 


Ala Gly Leu Thr Ala Phe Met Arg Ser Ile Gly Asp Thr Thr Phe Arg 
145                 150                 155                 160 


Leu Asp Arg Trp Glu Leu Glu Leu Asn Ser Ala Ile Pro Gly Asp Ala 
                165                 170                 175     


Arg Asp Thr Ser Ser Pro Arg Ala Val Thr Glu Ser Leu Gln Lys Leu 
            180                 185                 190         


Thr Leu Gly Ser Ala Leu Ala Ala Pro Gln Arg Gln Gln Phe Val Asp 
        195                 200                 205             


Trp Leu Lys Gly Asn Thr Thr Gly Asn His Arg Ile Arg Ala Ala Val 
    210                 215                 220                 


Pro Ala Asp Trp Ala Val Gly Asp Lys Thr Gly Thr Cys Gly Val Tyr 
225                 230                 235                 240 


Ala Asn Asp Tyr Ala Val Val Trp Pro Thr Gly Arg Ala Pro Ile Val 
                245                 250                 255     


Leu Ala Val Tyr Thr Arg Ala Pro Asn Lys Asp Asp Lys His Ser Glu 
            260                 265                 270         


Ala Val Ile Ala Ala Ala Ala Arg Leu Ala Leu Glu Gly Leu Gly Val 
        275                 280                 285             


Asn Gly Gln 
    290     


<210>  64
<211>  292
<212>  PRT
<213>  artificial

<220>
<223>  KPC-15

<400>  64

Met Ser Leu Tyr Arg Arg Leu Val Leu Leu Ser Cys Leu Ser Trp Pro 
1               5                   10                  15      


Leu Ala Gly Phe Ser Ala Thr Ala Leu Thr Asn Leu Val Ala Glu Pro 
            20                  25                  30          


Phe Ala Lys Leu Glu Gln Asp Phe Gly Gly Ser Ile Gly Val Tyr Ala 
        35                  40                  45              


Met Asp Thr Gly Ser Gly Ala Thr Val Ser Tyr Arg Ala Glu Glu Arg 
    50                  55                  60                  


Phe Pro Leu Cys Ser Ser Phe Lys Gly Phe Leu Ala Ala Ala Val Leu 
65                  70                  75                  80  


Ala Arg Ser Gln Gln Gln Ala Gly Leu Leu Asp Thr Pro Ile Arg Tyr 
                85                  90                  95      


Gly Lys Asn Ala Leu Val Arg Trp Ser Pro Ile Ser Glu Lys Tyr Leu 
            100                 105                 110         


Thr Thr Gly Met Thr Val Leu Glu Leu Ser Ala Ala Ala Val Gln Tyr 
        115                 120                 125             


Ser Asp Asn Ala Ala Ala Asn Leu Leu Leu Lys Glu Leu Gly Gly Pro 
    130                 135                 140                 


Ala Lys Leu Thr Ala Phe Met Arg Ser Ile Gly Asp Thr Thr Phe Arg 
145                 150                 155                 160 


Leu Asp Arg Trp Glu Leu Glu Leu Asn Ser Ala Ile Pro Gly Asp Ala 
                165                 170                 175     


Arg Asp Thr Ser Ser Pro Arg Ala Val Thr Glu Ser Leu Gln Lys Leu 
            180                 185                 190         


Thr Leu Gly Ser Ala Leu Ala Ala Pro Gln Arg Gln Gln Phe Val Asp 
        195                 200                 205             


Trp Leu Lys Gly Asn Thr Thr Gly Asn His Arg Ile Arg Ala Ala Val 
    210                 215                 220                 


Pro Ala Asp Trp Ala Val Gly Asp Lys Thr Gly Thr Cys Gly Gly Tyr 
225                 230                 235                 240 


Gly Thr Ala Asn Asp Tyr Ala Trp Trp Pro Thr Gly Arg Ala Pro Ile 
                245                 250                 255     


Val Leu Ala Val Tyr Thr Arg Ala Pro Asn Lys Asp Asp Lys Tyr Ser 
            260                 265                 270         


Glu Ala Val Ile Ala Ala Ala Ala Arg Leu Ala Leu Glu Gly Leu Gly 
        275                 280                 285             


Val Asn Gly Gln 
    290         


<210>  65
<211>  293
<212>  PRT
<213>  artificial

<220>
<223>  KPC-17

<400>  65

Met Ser Leu Tyr Arg Arg Leu Val Leu Leu Ser Cys Leu Ser Trp Pro 
1               5                   10                  15      


Leu Ala Gly Phe Ser Ala Thr Ala Leu Thr Asn Leu Val Ala Glu Pro 
            20                  25                  30          


Phe Ala Lys Leu Glu Gln Asp Phe Gly Gly Ser Ile Gly Val Tyr Ala 
        35                  40                  45              


Met Asp Thr Gly Ser Gly Ala Thr Val Ser Tyr Arg Ala Glu Glu Arg 
    50                  55                  60                  


Phe Pro Leu Cys Ser Ser Phe Lys Gly Phe Leu Ala Ala Ala Val Leu 
65                  70                  75                  80  


Ala Arg Ser Gln Gln Gln Ala Gly Leu Leu Asp Thr Pro Ile Arg Tyr 
                85                  90                  95      


Gly Lys Asn Ala Leu Val Pro Trp Ser Pro Ile Ser Glu Lys Tyr Leu 
            100                 105                 110         


Thr Thr Gly Met Thr Val Ala Glu Leu Ser Ala Ala Ala Val Gln Tyr 
        115                 120                 125             


Ser Asp Asn Ala Ala Ala Asn Leu Leu Leu Lys Glu Leu Gly Gly Pro 
    130                 135                 140                 


Ala Gly Leu Thr Ala Phe Met Arg Ser Ile Gly Asp Thr Thr Phe Arg 
145                 150                 155                 160 


Leu Asp Arg Trp Glu Leu Glu Leu Asn Ser Ala Ile Pro Gly Asp Ala 
                165                 170                 175     


Arg Asp Thr Ser Ser Pro Arg Ala Val Thr Glu Ser Leu Gln Lys Leu 
            180                 185                 190         


Thr Leu Gly Ser Ala Leu Ala Ala Pro Gln Arg Gln Gln Leu Val Asp 
        195                 200                 205             


Trp Leu Lys Gly Asn Thr Thr Gly Asn His Arg Ile Arg Ala Ala Val 
    210                 215                 220                 


Pro Ala Asp Trp Ala Val Gly Asp Lys Thr Gly Thr Cys Gly Val Tyr 
225                 230                 235                 240 


Gly Thr Ala Asn Asp Tyr Ala Val Val Trp Pro Thr Gly Arg Ala Pro 
                245                 250                 255     


Ile Val Leu Ala Val Tyr Thr Arg Ala Pro Asn Lys Asp Asp Lys His 
            260                 265                 270         


Ser Glu Ala Val Ile Ala Ala Ala Ala Arg Leu Ala Leu Glu Gly Leu 
        275                 280                 285             


Gly Val Asn Gly Gln 
    290             


<210>  66
<211>  269
<212>  PRT
<213>  artificial

<220>
<223>  NDM-1

<400>  66

Met Glu Leu Pro Asn Ile Met His Pro Val Ala Lys Leu Ser Thr Ala 
1               5                   10                  15      


Leu Ala Ala Ala Leu Met Leu Ser Gly Cys Met Pro Gly Glu Ile Arg 
            20                  25                  30          


Pro Thr Ile Gly Gln Gln Met Glu Thr Gly Asp Gln Arg Phe Gly Asp 
        35                  40                  45              


Leu Val Phe Arg Gln Leu Ala Pro Asn Val Trp Gln His Thr Ser Tyr 
    50                  55                  60                  


Leu Asp Met Pro Gly Phe Gly Ala Val Ala Ser Asn Gly Leu Ile Val 
65                  70                  75                  80  


Arg Asp Gly Gly Arg Val Leu Val Val Asp Thr Ala Trp Thr Asp Asp 
                85                  90                  95      


Gln Thr Ala Gln Ile Leu Asn Trp Ile Lys Gln Glu Ile Asn Leu Pro 
            100                 105                 110         


Val Ala Leu Ala Trp Thr His Ala His Gln Asp Lys Met Gly Gly Met 
        115                 120                 125             


Asp Ala Leu His Ala Ala Gly Ile Ala Thr Tyr Ala Asn Ala Leu Ser 
    130                 135                 140                 


Asn Gln Leu Ala Pro Gln Glu Gly Met Val Ala Ala Gln His Ser Leu 
145                 150                 155                 160 


Thr Phe Ala Ala Asn Gly Val Trp Glu Pro Ala Thr Ala Pro Asn Phe 
                165                 170                 175     


Gly Pro Leu Lys Val Phe Tyr Pro Gly Pro Gly His Thr Ser Asp Asn 
            180                 185                 190         


Ile Thr Val Gly Ile Asp Gly Thr Asp Ile Ala Phe Gly Gly Cys Leu 
        195                 200                 205             


Ile Lys Asp Ser Lys Ala Lys Ser Leu Gly Asn Leu Gly Asp Ala Asp 
    210                 215                 220                 


Thr Glu His Tyr Ala Ala Ser Ala Arg Ala Phe Gly Ala Ala Phe Pro 
225                 230                 235                 240 


Lys Ala Ser Met Ile Val Met Ser His Ser Ala Pro Asp Ser Arg Ala 
                245                 250                 255     


Ala Ile Thr His Thr Ala Arg Met Ala Asp Lys Leu Arg 
            260                 265                 


<210>  67
<211>  269
<212>  PRT
<213>  artificial

<220>
<223>  NDM-2

<400>  67

Met Glu Leu Pro Asn Ile Met His Pro Val Ala Lys Leu Ser Thr Ala 
1               5                   10                  15      


Leu Ala Ala Ala Leu Met Leu Ser Gly Cys Met Ala Gly Glu Ile Arg 
            20                  25                  30          


Pro Thr Ile Gly Gln Gln Met Glu Thr Gly Asp Gln Arg Phe Gly Asp 
        35                  40                  45              


Leu Val Phe Arg Gln Leu Ala Pro Asn Val Trp Gln His Thr Ser Tyr 
    50                  55                  60                  


Leu Asp Met Pro Gly Phe Gly Ala Val Ala Ser Asn Gly Leu Ile Val 
65                  70                  75                  80  


Arg Asp Gly Gly Arg Val Leu Val Val Asp Thr Ala Trp Thr Asp Asp 
                85                  90                  95      


Gln Thr Ala Gln Ile Leu Asn Trp Ile Lys Gln Glu Ile Asn Leu Pro 
            100                 105                 110         


Val Ala Leu Ala Trp Thr His Ala His Gln Asp Lys Met Gly Gly Met 
        115                 120                 125             


Asp Ala Leu His Ala Ala Gly Ile Ala Thr Tyr Ala Asn Ala Leu Ser 
    130                 135                 140                 


Asn Gln Leu Ala Pro Gln Glu Gly Met Val Ala Ala Gln His Ser Leu 
145                 150                 155                 160 


Thr Phe Ala Ala Asn Gly Val Trp Glu Pro Ala Thr Ala Pro Asn Phe 
                165                 170                 175     


Gly Pro Leu Lys Val Phe Tyr Pro Gly Pro Gly His Thr Ser Asp Asn 
            180                 185                 190         


Ile Thr Val Gly Ile Asp Gly Thr Asp Ile Ala Phe Gly Gly Cys Leu 
        195                 200                 205             


Ile Lys Asp Ser Lys Ala Lys Ser Leu Gly Asn Leu Gly Asp Ala Asp 
    210                 215                 220                 


Thr Glu His Tyr Ala Ala Ser Ala Arg Ala Phe Gly Ala Ala Phe Pro 
225                 230                 235                 240 


Lys Ala Ser Met Ile Val Met Ser His Ser Ala Pro Asp Ser Arg Ala 
                245                 250                 255     


Ala Ile Thr His Thr Ala Arg Met Ala Asp Lys Leu Arg 
            260                 265                 


<210>  68
<211>  269
<212>  PRT
<213>  artificial

<220>
<223>  NDM-3

<400>  68

Met Glu Leu Pro Asn Ile Met His Pro Val Ala Lys Leu Ser Thr Ala 
1               5                   10                  15      


Leu Ala Ala Ala Leu Met Leu Ser Gly Cys Met Pro Gly Glu Ile Arg 
            20                  25                  30          


Pro Thr Ile Gly Gln Gln Met Glu Thr Gly Asp Gln Arg Phe Gly Asp 
        35                  40                  45              


Leu Val Phe Arg Gln Leu Ala Pro Asn Val Trp Gln His Thr Ser Tyr 
    50                  55                  60                  


Leu Asp Met Pro Gly Phe Gly Ala Val Ala Ser Asn Gly Leu Ile Val 
65                  70                  75                  80  


Arg Asp Gly Gly Arg Val Leu Val Val Asp Thr Ala Trp Thr Asn Asp 
                85                  90                  95      


Gln Thr Ala Gln Ile Leu Asn Trp Ile Lys Gln Glu Ile Asn Leu Pro 
            100                 105                 110         


Val Ala Leu Ala Trp Thr His Ala His Gln Asp Lys Met Gly Gly Met 
        115                 120                 125             


Asp Ala Leu His Ala Ala Gly Ile Ala Thr Tyr Ala Asn Ala Leu Ser 
    130                 135                 140                 


Asn Gln Leu Ala Pro Gln Glu Gly Met Val Ala Ala Gln His Ser Leu 
145                 150                 155                 160 


Thr Phe Ala Ala Asn Gly Val Trp Glu Pro Ala Thr Ala Pro Asn Phe 
                165                 170                 175     


Gly Pro Leu Lys Val Phe Tyr Pro Gly Pro Gly His Thr Ser Asp Asn 
            180                 185                 190         


Ile Thr Val Gly Ile Asp Gly Thr Asp Ile Ala Phe Gly Gly Cys Leu 
        195                 200                 205             


Ile Lys Asp Ser Lys Ala Lys Ser Leu Gly Asn Leu Gly Asp Ala Asp 
    210                 215                 220                 


Thr Glu His Tyr Ala Ala Ser Ala Arg Ala Phe Gly Ala Ala Phe Pro 
225                 230                 235                 240 


Lys Ala Ser Met Ile Val Met Ser His Ser Ala Pro Asp Ser Arg Ala 
                245                 250                 255     


Ala Ile Thr His Thr Ala Arg Met Ala Asp Lys Leu Arg 
            260                 265                 


<210>  69
<211>  268
<212>  PRT
<213>  artificial

<220>
<223>  NDM-4

<400>  69

Met Glu Leu Pro Asn Ile Met His Pro Val Ala Lys Leu Ser Thr Ala 
1               5                   10                  15      


Leu Ala Ala Ala Leu Met Leu Ser Gly Cys Met Pro Gly Glu Ile Arg 
            20                  25                  30          


Pro Thr Ile Gly Gln Gln Met Glu Thr Gly Asp Gln Arg Phe Gly Asp 
        35                  40                  45              


Leu Val Phe Arg Gln Leu Ala Pro Asn Val Trp Gln His Thr Ser Tyr 
    50                  55                  60                  


Leu Asp Met Pro Gly Phe Gly Ala Val Ala Ser Asn Gly Leu Ile Val 
65                  70                  75                  80  


Arg Asp Gly Gly Arg Val Leu Val Val Asp Thr Ala Trp Thr Asp Asp 
                85                  90                  95      


Gln Thr Ala Gln Ile Leu Asn Trp Ile Lys Gln Glu Ile Asn Leu Pro 
            100                 105                 110         


Val Ala Leu Ala Trp Thr His Ala His Gln Asp Lys Met Gly Gly Met 
        115                 120                 125             


Asp Ala Leu His Ala Ala Gly Ile Ala Thr Tyr Ala Asn Ala Leu Ser 
    130                 135                 140                 


Asn Gln Leu Ala Pro Gln Glu Gly Leu Val Ala Ala Gln His Ser Leu 
145                 150                 155                 160 


Thr Phe Ala Ala Asn Gly Trp Glu Pro Ala Thr Ala Pro Asn Phe Gly 
                165                 170                 175     


Pro Leu Lys Val Phe Tyr Pro Gly Pro Gly His Thr Ser Asp Asn Ile 
            180                 185                 190         


Thr Val Gly Ile Asp Gly Thr Asp Ile Ala Phe Gly Gly Cys Leu Ile 
        195                 200                 205             


Lys Asp Ser Lys Ala Lys Ser Leu Gly Asn Leu Gly Asp Ala Asp Thr 
    210                 215                 220                 


Glu His Tyr Ala Ala Ser Ala Arg Ala Phe Gly Ala Ala Phe Pro Lys 
225                 230                 235                 240 


Ala Ser Met Ile Val Met Ser His Ser Ala Pro Asp Ser Arg Ala Ala 
                245                 250                 255     


Ile Thr His Thr Ala Arg Met Ala Asp Lys Leu Arg 
            260                 265             


<210>  70
<211>  270
<212>  PRT
<213>  artificial

<220>
<223>  NDM-5

<400>  70

Met Glu Leu Pro Asn Ile Met His Pro Val Ala Lys Leu Ser Thr Ala 
1               5                   10                  15      


Leu Ala Ala Ala Leu Met Leu Ser Gly Cys Met Pro Gly Glu Ile Arg 
            20                  25                  30          


Pro Thr Ile Gly Gln Gln Met Glu Thr Gly Asp Gln Arg Phe Gly Asp 
        35                  40                  45              


Leu Val Phe Arg Gln Leu Ala Pro Asn Val Trp Gln His Thr Ser Tyr 
    50                  55                  60                  


Leu Asp Met Pro Gly Phe Gly Ala Val Ala Ser Asn Gly Leu Ile Val 
65                  70                  75                  80  


Arg Asp Gly Gly Arg Val Leu Leu Val Asp Thr Ala Trp Thr Asp Asp 
                85                  90                  95      


Gln Thr Ala Gln Ile Leu Asn Trp Ile Lys Gln Glu Ile Asn Leu Pro 
            100                 105                 110         


Val Ala Leu Ala Val Val Thr His Ala His Gln Asp Lys Met Gly Gly 
        115                 120                 125             


Met Asp Ala Leu His Ala Ala Gly Ile Ala Thr Tyr Ala Asn Ala Leu 
    130                 135                 140                 


Ser Asn Gln Leu Ala Pro Gln Glu Gly Leu Val Ala Ala Gln His Ser 
145                 150                 155                 160 


Leu Thr Phe Ala Ala Asn Gly Val Trp Glu Pro Ala Thr Ala Pro Asn 
                165                 170                 175     


Phe Gly Pro Leu Lys Val Phe Tyr Pro Gly Pro Gly His Thr Ser Asp 
            180                 185                 190         


Asn Ile Thr Val Gly Ile Asp Gly Thr Asp Ile Ala Phe Gly Gly Cys 
        195                 200                 205             


Leu Ile Lys Asp Ser Lys Ala Lys Ser Leu Gly Asn Leu Gly Asp Ala 
    210                 215                 220                 


Asp Thr Glu His Tyr Ala Ala Ser Ala Arg Ala Phe Gly Ala Ala Phe 
225                 230                 235                 240 


Pro Lys Ala Ser Met Ile Val Met Ser His Ser Ala Pro Asp Ser Arg 
                245                 250                 255     


Ala Ala Ile Thr His Thr Ala Arg Met Ala Asp Lys Leu Arg 
            260                 265                 270 


<210>  71
<211>  269
<212>  PRT
<213>  artificial

<220>
<223>  NDM-6

<400>  71

Met Glu Leu Pro Asn Ile Met His Pro Val Ala Lys Leu Ser Thr Ala 
1               5                   10                  15      


Leu Ala Ala Ala Leu Met Leu Ser Gly Cys Met Pro Gly Glu Ile Arg 
            20                  25                  30          


Pro Thr Ile Gly Gln Gln Met Glu Thr Gly Asp Gln Arg Phe Gly Asp 
        35                  40                  45              


Leu Val Phe Arg Gln Leu Ala Pro Asn Val Trp Gln His Thr Ser Tyr 
    50                  55                  60                  


Leu Asp Met Pro Gly Phe Gly Ala Val Ala Ser Asn Gly Leu Ile Val 
65                  70                  75                  80  


Arg Asp Gly Gly Arg Val Leu Val Val Asp Thr Ala Trp Thr Asp Asp 
                85                  90                  95      


Gln Thr Ala Gln Ile Leu Asn Trp Ile Lys Gln Glu Ile Asn Leu Pro 
            100                 105                 110         


Val Ala Leu Ala Trp Thr His Ala His Gln Asp Lys Met Gly Gly Met 
        115                 120                 125             


Asp Ala Leu His Ala Ala Gly Ile Ala Thr Tyr Ala Asn Ala Leu Ser 
    130                 135                 140                 


Asn Gln Leu Ala Pro Gln Glu Gly Met Val Ala Ala Gln His Ser Leu 
145                 150                 155                 160 


Thr Phe Ala Ala Asn Gly Val Trp Glu Pro Ala Thr Ala Pro Asn Phe 
                165                 170                 175     


Gly Pro Leu Lys Val Phe Tyr Pro Gly Pro Gly His Thr Ser Asp Asn 
            180                 185                 190         


Ile Thr Val Gly Ile Asp Gly Thr Asp Ile Ala Phe Gly Gly Cys Leu 
        195                 200                 205             


Ile Lys Asp Ser Lys Ala Lys Ser Leu Gly Asn Leu Gly Asp Ala Asp 
    210                 215                 220                 


Thr Glu His Tyr Ala Ala Ser Val Arg Ala Phe Gly Ala Ala Phe Pro 
225                 230                 235                 240 


Lys Ala Ser Met Ile Val Met Ser His Ser Ala Pro Asp Ser Arg Ala 
                245                 250                 255     


Ala Ile Thr His Thr Ala Arg Met Ala Asp Lys Leu Arg 
            260                 265                 


<210>  72
<211>  268
<212>  PRT
<213>  artificial

<220>
<223>  NDM-7

<400>  72

Met Glu Leu Pro Asn Ile Met His Pro Val Ala Lys Leu Ser Thr Ala 
1               5                   10                  15      


Leu Ala Ala Ala Leu Met Leu Ser Gly Cys Met Pro Gly Glu Ile Arg 
            20                  25                  30          


Pro Thr Ile Gly Gln Gln Met Glu Thr Gly Asp Gln Arg Phe Gly Asp 
        35                  40                  45              


Leu Val Phe Arg Gln Leu Ala Pro Asn Val Trp Gln His Thr Ser Tyr 
    50                  55                  60                  


Leu Asp Met Pro Gly Phe Gly Ala Val Ala Ser Asn Gly Leu Ile Val 
65                  70                  75                  80  


Arg Asp Gly Gly Arg Val Leu Val Val Asp Thr Ala Trp Thr Asp Asp 
                85                  90                  95      


Gln Thr Ala Gln Ile Leu Asn Trp Ile Lys Gln Glu Ile Asn Leu Pro 
            100                 105                 110         


Val Ala Leu Ala Trp Thr His Ala His Gln Asp Lys Met Gly Gly Met 
        115                 120                 125             


Asn Ala Leu His Ala Ala Gly Ile Ala Thr Tyr Ala Asn Ala Leu Ser 
    130                 135                 140                 


Asn Gln Leu Ala Pro Gln Glu Gly Leu Val Ala Ala Gln His Ser Leu 
145                 150                 155                 160 


Thr Phe Ala Ala Asn Gly Trp Glu Pro Ala Thr Ala Pro Asn Phe Gly 
                165                 170                 175     


Pro Leu Lys Val Phe Tyr Pro Gly Pro Gly His Thr Ser Asp Asn Ile 
            180                 185                 190         


Thr Val Gly Ile Asp Gly Thr Asp Ile Ala Phe Gly Gly Cys Leu Ile 
        195                 200                 205             


Lys Asp Ser Lys Ala Lys Ser Leu Gly Asn Leu Gly Asp Ala Asp Thr 
    210                 215                 220                 


Glu His Tyr Ala Ala Ser Ala Arg Ala Phe Gly Ala Ala Phe Pro Lys 
225                 230                 235                 240 


Ala Ser Met Ile Val Met Ser His Ser Ala Pro Asp Ser Arg Ala Ala 
                245                 250                 255     


Ile Thr His Thr Ala Arg Met Ala Asp Lys Leu Arg 
            260                 265             


<210>  73
<211>  269
<212>  PRT
<213>  artificial

<220>
<223>  NDM-8

<400>  73

Met Glu Leu Pro Asn Ile Met His Pro Val Ala Lys Leu Ser Thr Ala 
1               5                   10                  15      


Leu Ala Ala Ala Leu Met Leu Ser Gly Cys Met Pro Gly Glu Ile Arg 
            20                  25                  30          


Pro Thr Ile Gly Gln Gln Met Glu Thr Gly Asp Gln Arg Phe Gly Asp 
        35                  40                  45              


Leu Val Phe Arg Gln Leu Ala Pro Asn Val Trp Gln His Thr Ser Tyr 
    50                  55                  60                  


Leu Asp Met Pro Gly Phe Gly Ala Val Ala Ser Asn Gly Leu Ile Val 
65                  70                  75                  80  


Arg Asp Gly Gly Arg Val Leu Val Val Asp Thr Ala Trp Thr Asp Asp 
                85                  90                  95      


Gln Thr Ala Gln Ile Leu Asn Trp Ile Lys Gln Glu Ile Asn Leu Pro 
            100                 105                 110         


Val Ala Leu Ala Trp Thr His Ala His Gln Asp Lys Met Gly Gly Met 
        115                 120                 125             


Gly Ala Leu His Ala Ala Gly Ile Ala Thr Tyr Ala Asn Ala Leu Ser 
    130                 135                 140                 


Asn Gln Leu Ala Pro Gln Glu Gly Leu Val Ala Ala Gln His Ser Leu 
145                 150                 155                 160 


Thr Phe Ala Ala Asn Gly Val Trp Glu Pro Ala Thr Ala Pro Asn Phe 
                165                 170                 175     


Gly Pro Leu Lys Val Phe Tyr Pro Gly Pro Gly His Thr Ser Asp Asn 
            180                 185                 190         


Ile Thr Val Gly Ile Asp Gly Thr Asp Ile Ala Phe Gly Gly Cys Leu 
        195                 200                 205             


Ile Lys Asp Ser Lys Ala Lys Ser Leu Gly Asn Leu Gly Asp Ala Asp 
    210                 215                 220                 


Thr Glu His Tyr Ala Ala Ser Ala Arg Ala Phe Gly Ala Ala Phe Pro 
225                 230                 235                 240 


Lys Ala Ser Met Ile Val Met Ser His Ser Ala Pro Asp Ser Arg Ala 
                245                 250                 255     


Ala Ile Thr His Thr Ala Arg Met Ala Asp Lys Leu Arg 
            260                 265                 


<210>  74
<211>  268
<212>  PRT
<213>  artificial

<220>
<223>  NDM-9

<400>  74

Met Glu Leu Pro Asn Ile Met His Pro Val Ala Lys Leu Ser Thr Ala 
1               5                   10                  15      


Leu Ala Ala Ala Leu Met Leu Ser Gly Cys Met Pro Gly Glu Ile Arg 
            20                  25                  30          


Pro Thr Ile Gly Gln Gln Met Glu Thr Gly Asp Gln Arg Phe Gly Asp 
        35                  40                  45              


Leu Val Phe Arg Gln Leu Ala Pro Asn Val Trp Gln His Thr Ser Tyr 
    50                  55                  60                  


Leu Asp Met Pro Gly Phe Gly Ala Val Ala Ser Asn Gly Leu Ile Val 
65                  70                  75                  80  


Arg Asp Gly Gly Arg Val Leu Val Val Asp Thr Ala Trp Thr Asp Asp 
                85                  90                  95      


Gln Thr Ala Gln Ile Leu Asn Trp Ile Lys Gln Glu Ile Asn Leu Pro 
            100                 105                 110         


Val Ala Leu Ala Trp Thr His Ala His Gln Asp Lys Met Gly Gly Met 
        115                 120                 125             


Asp Ala Leu His Ala Ala Gly Ile Ala Thr Tyr Ala Asn Ala Leu Ser 
    130                 135                 140                 


Asn Gln Leu Ala Pro Gln Lys Gly Met Val Ala Ala Gln His Ser Leu 
145                 150                 155                 160 


Thr Phe Ala Ala Asn Gly Trp Glu Pro Ala Thr Ala Pro Asn Phe Gly 
                165                 170                 175     


Pro Leu Lys Val Phe Tyr Pro Gly Pro Gly His Thr Ser Asp Asn Ile 
            180                 185                 190         


Thr Val Gly Ile Asp Gly Thr Asp Ile Ala Phe Gly Gly Cys Leu Ile 
        195                 200                 205             


Lys Asp Ser Lys Ala Lys Ser Leu Gly Asn Leu Gly Asp Ala Asp Thr 
    210                 215                 220                 


Glu His Tyr Ala Ala Ser Ala Arg Ala Phe Gly Ala Ala Phe Pro Lys 
225                 230                 235                 240 


Ala Ser Met Ile Val Met Ser His Ser Ala Pro Asp Ser Arg Ala Ala 
                245                 250                 255     


Ile Thr His Thr Ala Arg Met Ala Asp Lys Leu Arg 
            260                 265             


<210>  75
<211>  269
<212>  PRT
<213>  artificial

<220>
<223>  NDM-10

<400>  75

Met Glu Leu Pro Asn Ile Met His Pro Val Ala Lys Leu Ser Thr Ala 
1               5                   10                  15      


Leu Ala Ala Ala Leu Met Leu Ser Gly Cys Met Pro Gly Glu Ile Ser 
            20                  25                  30          


Pro Thr Ile Asp Gln Gln Met Glu Thr Gly Asp Gln Arg Phe Gly Asp 
        35                  40                  45              


Leu Val Phe Arg Gln Leu Ala Pro Asn Val Trp Gln His Thr Ser Tyr 
    50                  55                  60                  


Leu Asp Met Pro Ser Phe Gly Ala Val Thr Ser Asn Gly Leu Ile Val 
65                  70                  75                  80  


Arg Asp Gly Gly Arg Val Leu Trp Asp Thr Ala Trp Thr Asp Asp Gln 
                85                  90                  95      


Thr Ala Gln Ile Leu Asn Trp Ile Lys Gln Glu Ile Asn Leu Pro Val 
            100                 105                 110         


Ala Leu Ala Val Val Thr His Ala His Gln Asp Lys Met Gly Gly Met 
        115                 120                 125             


Asp Ala Leu His Ala Ala Gly Ile Ala Thr Tyr Ala Asn Ala Leu Ser 
    130                 135                 140                 


Asn Gln Leu Ala Pro Gln Glu Gly Met Val Ala Ala Gln His Ser Leu 
145                 150                 155                 160 


Thr Phe Ala Ala Asn Gly Trp Val Glu Pro Ala Thr Ala Pro Asn Phe 
                165                 170                 175     


Gly Pro Leu Lys Val Phe Tyr Pro Gly Pro Gly His Thr Ser Asp Asn 
            180                 185                 190         


Ile Thr Val Gly Ile Asp Arg Thr Asp Ile Ala Phe Gly Gly Cys Leu 
        195                 200                 205             


Ile Lys Asp Ser Lys Ala Lys Ser Leu Gly Asn Leu Gly Asp Ala Asp 
    210                 215                 220                 


Thr Glu His Tyr Ala Ala Ser Ala Arg Ala Phe Gly Ala Ala Phe Pro 
225                 230                 235                 240 


Lys Ala Ser Met Ile Val Met Ser His Ser Ala Pro Asp Ser Arg Ala 
                245                 250                 255     


Ala Ile Thr His Thr Ala Arg Met Ala Asp Lys Leu Arg 
            260                 265                 


<210>  76
<211>  268
<212>  PRT
<213>  artificial

<220>
<223>  NDM-11

<400>  76

Met Glu Leu Pro Asn Ile Met His Pro Val Ala Lys Leu Ser Thr Ala 
1               5                   10                  15      


Leu Ala Ala Ala Leu Met Leu Ser Gly Cys Met Pro Gly Glu Ile Arg 
            20                  25                  30          


Pro Thr Ile Gly Gln Gln Met Glu Thr Gly Asp Gln Arg Phe Gly Asp 
        35                  40                  45              


Leu Val Phe Arg Gln Leu Ala Pro Asn Val Trp Gln His Thr Ser Tyr 
    50                  55                  60                  


Leu Asp Met Pro Gly Phe Gly Ala Val Ala Ser Asn Gly Leu Ile Val 
65                  70                  75                  80  


Arg Asp Gly Gly Arg Val Leu Val Val Asp Thr Ala Trp Thr Asp Asp 
                85                  90                  95      


Gln Thr Ala Gln Ile Leu Asn Trp Ile Lys Gln Glu Ile Asn Leu Pro 
            100                 105                 110         


Val Ala Leu Ala Trp Thr His Ala His Gln Asp Lys Met Gly Gly Met 
        115                 120                 125             


Asp Ala Leu His Ala Ala Gly Ile Ala Thr Tyr Ala Asn Ala Leu Ser 
    130                 135                 140                 


Asn Gln Leu Ala Pro Gln Glu Gly Leu Val Ala Ala Gln His Ser Leu 
145                 150                 155                 160 


Thr Phe Ala Ala Asn Gly Trp Glu Pro Ala Thr Ala Pro Asn Phe Gly 
                165                 170                 175     


Pro Leu Lys Val Phe Tyr Pro Gly Pro Gly His Thr Ser Asp Asn Ile 
            180                 185                 190         


Thr Val Gly Ile Asp Gly Thr Asp Ile Ala Phe Gly Gly Cys Leu Ile 
        195                 200                 205             


Lys Asp Ser Lys Ala Lys Ser Leu Gly Asn Leu Asp Asp Ala Asp Thr 
    210                 215                 220                 


Glu His Tyr Ala Ala Ser Ala Arg Ala Phe Gly Ala Ala Phe Pro Lys 
225                 230                 235                 240 


Ala Ser Met Ile Val Met Ser His Ser Ala Pro Asp Ser Arg Ala Ala 
                245                 250                 255     


Ile Thr His Thr Ala Arg Met Ala Asp Lys Leu Arg 
            260                 265             


<210>  77
<211>  268
<212>  PRT
<213>  artificial

<220>
<223>  NDM-12

<400>  77

Met Glu Leu Pro Asn Ile Met His Pro Val Ala Lys Leu Ser Thr Ala 
1               5                   10                  15      


Leu Ala Ala Ala Leu Met Leu Ser Gly Cys Met Pro Gly Glu Ile Arg 
            20                  25                  30          


Pro Thr Ile Gly Gln Gln Met Glu Thr Gly Asp Gln Arg Phe Gly Asp 
        35                  40                  45              


Leu Val Phe Arg Gln Leu Ala Pro Asn Val Trp Gln His Thr Ser Tyr 
    50                  55                  60                  


Leu Asp Met Pro Gly Phe Gly Ala Val Ala Ser Asn Gly Leu Ile Val 
65                  70                  75                  80  


Arg Asp Gly Gly Arg Val Leu Val Val Asp Thr Ala Trp Thr Asp Asp 
                85                  90                  95      


Gln Thr Ala Gln Ile Leu Asn Trp Ile Lys Gln Glu Ile Asn Leu Pro 
            100                 105                 110         


Val Ala Leu Ala Trp Thr His Ala His Gln Asp Lys Met Gly Gly Met 
        115                 120                 125             


Asp Ala Leu His Ala Ala Gly Ile Ala Thr Tyr Ala Asn Ala Leu Ser 
    130                 135                 140                 


Asn Gln Leu Ala Pro Gln Glu Gly Leu Val Ala Ala Gln His Ser Leu 
145                 150                 155                 160 


Thr Phe Ala Ala Asn Gly Trp Glu Pro Ala Thr Ala Pro Asn Phe Gly 
                165                 170                 175     


Pro Leu Lys Val Phe Tyr Pro Gly Pro Gly His Thr Ser Asp Asn Ile 
            180                 185                 190         


Thr Val Gly Ile Asp Gly Thr Asp Ile Ala Phe Gly Gly Cys Leu Ile 
        195                 200                 205             


Lys Asp Ser Lys Ala Lys Ser Leu Gly Asn Leu Asp Asp Ala Asp Thr 
    210                 215                 220                 


Glu His Tyr Ala Ala Ser Ala Arg Ala Phe Gly Ala Ala Phe Pro Lys 
225                 230                 235                 240 


Ala Ser Met Ile Val Met Ser His Ser Ala Pro Asp Ser Arg Ala Ala 
                245                 250                 255     


Ile Thr His Thr Ala Arg Met Ala Asp Lys Leu Arg 
            260                 265             


<210>  78
<211>  268
<212>  PRT
<213>  artificial

<220>
<223>  NDM-13

<400>  78

Met Glu Leu Pro Asn Ile Met His Pro Val Ala Lys Leu Ser Thr Ala 
1               5                   10                  15      


Leu Ala Ala Ala Leu Met Leu Ser Gly Cys Met Pro Gly Glu Ile Arg 
            20                  25                  30          


Pro Thr Ile Gly Gln Gln Met Glu Thr Gly Asp Gln Arg Phe Gly Asp 
        35                  40                  45              


Leu Val Phe Arg Gln Leu Ala Pro Asn Val Trp Gln His Thr Ser Tyr 
    50                  55                  60                  


Leu Asp Met Pro Gly Phe Gly Ala Val Ala Ser Asn Gly Leu Ile Val 
65                  70                  75                  80  


Arg Asp Gly Gly Arg Val Leu Val Val Asp Thr Ala Trp Thr Asn Asp 
                85                  90                  95      


Gln Thr Ala Gln Ile Leu Asn Trp Ile Lys Gln Glu Ile Asn Leu Pro 
            100                 105                 110         


Val Ala Leu Ala Trp Thr His Ala His Gln Asp Lys Met Gly Gly Met 
        115                 120                 125             


Asp Ala Leu His Ala Ala Gly Ile Ala Thr Tyr Ala Asn Ala Leu Ser 
    130                 135                 140                 


Asn Gln Leu Ala Pro Gln Glu Gly Leu Val Ala Ala Gln His Ser Leu 
145                 150                 155                 160 


Thr Phe Ala Ala Asn Gly Trp Glu Pro Ala Thr Ala Pro Asn Phe Gly 
                165                 170                 175     


Pro Leu Lys Val Phe Tyr Pro Gly Pro Gly His Thr Ser Asp Asn Ile 
            180                 185                 190         


Thr Val Gly Ile Asp Gly Thr Asp Ile Ala Phe Gly Gly Cys Leu Ile 
        195                 200                 205             


Lys Asp Ser Lys Ala Lys Ser Leu Gly Asn Leu Gly Asp Ala Asp Thr 
    210                 215                 220                 


Glu His Tyr Ala Ala Ser Ala Arg Ala Phe Gly Ala Ala Phe Pro Lys 
225                 230                 235                 240 


Ala Ser Met Ile Val Met Ser His Ser Ala Pro Asp Ser Arg Ala Ala 
                245                 250                 255     


Ile Thr His Thr Ala Arg Met Ala Asp Lys Leu Arg 
            260                 265             


<210>  79
<211>  260
<212>  PRT
<213>  artificial

<220>
<223>  P4A

<400>  79

Glu Met Lys Asp Asp Phe Ala Lys Leu Glu Glu Gln Phe Asp Ala Lys 
1               5                   10                  15      


Leu Gly Ile Phe Ala Leu Asp Thr Gly Thr Asn Arg Thr Val Ala Tyr 
            20                  25                  30          


Arg Pro Asp Glu Arg Phe Ala Phe Ala Ser Thr Ile Lys Ala Leu Thr 
        35                  40                  45              


Val Gly Val Leu Leu Gln Gln Lys Ser Ile Glu Asp Leu Asn Gln Arg 
    50                  55                  60                  


Ile Thr Thr Arg Asp Asp Leu Val Asn Tyr Asn Pro Ile Thr Glu Lys 
65                  70                  75                  80  


His Val Asp Thr Gly Met Thr Leu Lys Glu Leu Ala Asp Ala Ser Leu 
                85                  90                  95      


Arg Tyr Ser Asp Asn Ala Ala Gln Asn Leu Ile Leu Lys Gln Ile Gly 
            100                 105                 110         


Gly Pro Glu Ser Leu Lys Lys Glu Leu Arg Lys Ile Gly Asp Glu Val 
        115                 120                 125             


Thr Asn Pro Glu Arg Phe Glu Pro Glu Leu Asn Glu Val Asn Pro Gly 
    130                 135                 140                 


Glu Thr Gln Asp Thr Ser Thr Ala Arg Ala Leu Val Thr Ser Leu Arg 
145                 150                 155                 160 


Ala Phe Ala Leu Glu Asp Lys Leu Pro Ser Glu Lys Arg Glu Leu Leu 
                165                 170                 175     


Ile Asp Trp Met Lys Arg Asn Thr Thr Gly Asp Ala Leu Ile Arg Ala 
            180                 185                 190         


Gly Val Pro Asp Gly Trp Glu Val Gly Asp Lys Thr Gly Ser Gly Asp 
        195                 200                 205             


Tyr Gly Thr Arg Asn Asp Ile Ala Ile Ile Trp Pro Pro Lys Gly Asp 
    210                 215                 220                 


Pro Trp Leu Ala Val Leu Ser Ser Arg Asp Lys Lys Asp Ala Lys Tyr 
225                 230                 235                 240 


Asp Asn Lys Leu Ile Ala Glu Ala Thr Lys Trp Met Lys Ala Leu Asn 
                245                 250                 255     


Met Asn Gly Lys 
            260 


<210>  80
<211>  299
<212>  PRT
<213>  artificial

<220>
<223>  P4A + peptide signal

<400>  80

Met Ile Gln Lys Arg Lys Arg Thr Val Ser Phe Arg Leu Val Leu Met 
1               5                   10                  15      


Cys Thr Leu Leu Phe Val Ser Leu Pro Ile Thr Lys Thr Ser Ala Gln 
            20                  25                  30          


Ala Ser Lys Thr Glu Met Lys Asp Asp Phe Ala Lys Leu Glu Glu Gln 
        35                  40                  45              


Phe Asp Ala Lys Leu Gly Ile Phe Ala Leu Asp Thr Gly Thr Asn Arg 
    50                  55                  60                  


Thr Val Ala Tyr Arg Pro Asp Glu Arg Phe Ala Phe Ala Ser Thr Ile 
65                  70                  75                  80  


Lys Ala Leu Thr Val Gly Val Leu Leu Gln Gln Lys Ser Ile Glu Asp 
                85                  90                  95      


Leu Asn Gln Arg Ile Thr Tyr Thr Arg Asp Asp Leu Val Asn Tyr Asn 
            100                 105                 110         


Pro Ile Thr Glu Lys His Val Asp Thr Gly Met Thr Leu Lys Glu Leu 
        115                 120                 125             


Ala Asp Ala Ser Leu Arg Tyr Ser Asp Asn Ala Ala Gln Asn Leu Ile 
    130                 135                 140                 


Leu Lys Gln Ile Gly Gly Pro Glu Ser Leu Lys Lys Glu Leu Arg Lys 
145                 150                 155                 160 


Ile Gly Asp Glu Val Thr Asn Pro Glu Arg Phe Glu Pro Glu Leu Asn 
                165                 170                 175     


Glu Val Asn Pro Gly Glu Thr Gln Asp Thr Ser Thr Ala Arg Ala Leu 
            180                 185                 190         


Val Thr Ser Leu Arg Ala Phe Ala Leu Glu Asp Lys Leu Pro Ser Glu 
        195                 200                 205             


Lys Arg Glu Leu Leu Ile Asp Trp Met Lys Arg Asn Thr Thr Gly Asp 
    210                 215                 220                 


Ala Leu Ile Arg Ala Gly Val Pro Asp Gly Trp Glu Val Gly Asp Lys 
225                 230                 235                 240 


Thr Gly Ser Gly Asp Tyr Gly Thr Arg Asn Asp Ile Ala Ile Ile Trp 
                245                 250                 255     


Pro Pro Lys Gly Asp Pro Val Val Leu Ala Val Leu Ser Ser Arg Asp 
            260                 265                 270         


Lys Lys Asp Ala Lys Tyr Asp Asn Lys Leu Ile Ala Glu Ala Thr Lys 
        275                 280                 285             


Val Val Met Lys Ala Leu Asn Met Asn Gly Lys 
    290                 295                 


<210>  81
<211>  263
<212>  PRT
<213>  Escherichia coli

<400>  81

His Pro Glu Thr Leu Val Lys Val Lys Asp Ala Glu Asp Gln Leu Gly 
1               5                   10                  15      


Ala Arg Val Gly Tyr Ile Glu Leu Asp Leu Asn Ser Gly Lys Ile Leu 
            20                  25                  30          


Glu Ser Phe Arg Pro Glu Glu Arg Phe Pro Met Val Ser Thr Phe Lys 
        35                  40                  45              


Val Leu Leu Cys Gly Ala Val Leu Ser Arg Val Asp Ala Gly Gln Glu 
    50                  55                  60                  


Gln Leu Gly Arg Arg Ile His Tyr Ser Gln Asn Asp Leu Val Glu Tyr 
65                  70                  75                  80  


Ser Pro Val Thr Glu Lys His Leu Thr Asp Gly Met Thr Val Arg Glu 
                85                  90                  95      


Leu Cys Ser Ala Ala Ile Thr Met Ser Asp Asn Thr Ala Ala Asn Leu 
            100                 105                 110         


Leu Leu Thr Thr Ile Gly Gly Pro Lys Glu Leu Thr Ala Phe Leu His 
        115                 120                 125             


Asn Met Gly Asp His Val Thr Arg Leu Asp Arg Trp Glu Pro Glu Leu 
    130                 135                 140                 


Asn Glu Ala Ile Pro Asn Asp Glu Arg Asp Thr Thr Met Pro Ala Ala 
145                 150                 155                 160 


Met Ala Thr Thr Leu Arg Lys Leu Leu Thr Gly Glu Leu Leu Thr Leu 
                165                 170                 175     


Ala Ser Arg Gln Gln Leu Ile Asp Trp Met Glu Ala Asp Lys Val Ala 
            180                 185                 190         


Gly Pro Leu Leu Arg Ser Ala Leu Pro Ala Gly Trp Phe Ile Ala Asp 
        195                 200                 205             


Lys Ser Gly Ala Gly Glu Arg Gly Ser Arg Gly Ile Ile Ala Ala Leu 
    210                 215                 220                 


Gly Pro Asp Gly Lys Pro Ser Arg Ile Val Val Ile Tyr Thr Thr Gly 
225                 230                 235                 240 


Ser Gln Ala Thr Met Asp Glu Arg Asp Arg Gln Ile Ala Glu Ile Gly 
                245                 250                 255     


Ala Ser Leu Ile Lys His Trp 
            260             


<210>  82
<211>  263
<212>  PRT
<213>  Escherichia coli

<400>  82

Gln Thr Ser Ala Val Gln Gln Lys Leu Ala Ala Leu Glu Lys Ser Ser 
1               5                   10                  15      


Gly Gly Arg Leu Gly Val Ala Leu Ile Asp Thr Ala Asp Asn Thr Gln 
            20                  25                  30          


Val Leu Tyr Arg Gly Asp Glu Arg Phe Pro Met Cys Ser Thr Ser Lys 
        35                  40                  45              


Val Met Ala Ala Ala Ala Val Leu Lys Gln Ser Glu Thr Gln Lys Gln 
    50                  55                  60                  


Leu Leu Asn Gln Pro Val Glu Ile Lys Pro Ala Asp Leu Val Asn Tyr 
65                  70                  75                  80  


Asn Pro Ile Ala Glu Lys His Val Asn Gly Thr Met Thr Leu Ala Glu 
                85                  90                  95      


Leu Ser Ala Ala Ala Leu Gln Tyr Ser Asp Asn Thr Ala Met Asn Lys 
            100                 105                 110         


Leu Ile Ala Gln Leu Gly Gly Pro Gly Gly Val Thr Ala Phe Ala Arg 
        115                 120                 125             


Ala Ile Gly Asp Glu Thr Phe Arg Leu Asp Arg Thr Glu Pro Thr Leu 
    130                 135                 140                 


Asn Thr Ala Ile Pro Gly Asp Pro Arg Asp Thr Thr Thr Pro Arg Ala 
145                 150                 155                 160 


Met Ala Gln Thr Leu Arg Gln Leu Thr Leu Gly His Ala Leu Gly Glu 
                165                 170                 175     


Thr Gln Arg Ala Gln Leu Val Thr Trp Leu Lys Gly Asn Thr Thr Gly 
            180                 185                 190         


Ala Ala Ser Ile Arg Ala Gly Leu Pro Thr Ser Trp Thr Ala Gly Asp 
        195                 200                 205             


Lys Thr Gly Ser Gly Gly Tyr Gly Thr Thr Asn Asp Ile Ala Val Ile 
    210                 215                 220                 


Trp Pro Gln Gly Arg Ala Pro Leu Val Leu Val Thr Tyr Phe Thr Gln 
225                 230                 235                 240 


Pro Gln Gln Asn Ala Glu Ser Arg Arg Asp Val Leu Ala Ser Ala Ala 
                245                 250                 255     


Arg Ile Ile Ala Glu Gly Leu 
            260             


<210>  83
<211>  257
<212>  PRT
<213>  Staphylococcus aureus

<400>  83

Lys Glu Leu Asn Asp Leu Glu Lys Lys Tyr Asn Ala His Ile Gly Val 
1               5                   10                  15      


Tyr Ala Leu Asp Thr Lys Ser Gly Lys Glu Val Lys Phe Asn Ser Asp 
            20                  25                  30          


Lys Arg Phe Ala Tyr Ala Ser Thr Ser Lys Ala Ile Asn Ser Ala Ile 
        35                  40                  45              


Leu Leu Glu Gln Val Pro Tyr Asn Lys Leu Asn Lys Lys Val His Ile 
    50                  55                  60                  


Asn Lys Asp Asp Ile Val Ala Tyr Ser Pro Ile Leu Glu Lys Tyr Val 
65                  70                  75                  80  


Gly Lys Asp Ile Thr Leu Lys Ala Leu Ile Glu Ala Ser Met Thr Tyr 
                85                  90                  95      


Ser Asp Asn Thr Ala Asn Asn Lys Ile Ile Lys Glu Ile Gly Gly Ile 
            100                 105                 110         


Lys Lys Val Lys Gln Arg Leu Lys Glu Leu Gly Asp Lys Val Thr Asn 
        115                 120                 125             


Pro Val Arg Tyr Glu Ile Glu Leu Asn Tyr Tyr Ser Pro Lys Ser Lys 
    130                 135                 140                 


Lys Asp Thr Ser Thr Pro Ala Ala Phe Gly Lys Thr Leu Asn Lys Leu 
145                 150                 155                 160 


Ile Ala Asn Gly Lys Leu Ser Lys Glu Asn Lys Lys Phe Leu Leu Asp 
                165                 170                 175     


Leu Met Leu Asn Asn Lys Ser Gly Asp Thr Leu Ile Lys Asp Gly Val 
            180                 185                 190         


Pro Lys Asp Tyr Lys Val Ala Asp Lys Ser Gly Gln Ala Ile Thr Tyr 
        195                 200                 205             


Ala Ser Arg Asn Asp Val Ala Phe Val Tyr Pro Lys Gly Gln Ser Glu 
    210                 215                 220                 


Pro Ile Val Leu Val Ile Phe Thr Asn Lys Asp Asn Lys Ser Asp Lys 
225                 230                 235                 240 


Pro Asn Asp Lys Leu Ile Ser Glu Thr Ala Lys Ser Val Met Lys Glu 
                245                 250                 255     


Phe 
    


<210>  84
<211>  199
<212>  PRT
<213>  Escherichia coli

<400>  84

Met Ser Asn Ala Lys Thr Lys Leu Gly Ile Thr Lys Tyr Ser Ile Val 
1               5                   10                  15      


Thr Asn Ser Asn Asp Ser Val Thr Leu Arg Leu Met Thr Glu His Asp 
            20                  25                  30          


Leu Ala Met Leu Tyr Glu Trp Leu Asn Arg Ser His Ile Val Glu Trp 
        35                  40                  45              


Trp Gly Gly Glu Glu Ala Arg Pro Thr Leu Ala Asp Val Gln Glu Gln 
    50                  55                  60                  


Tyr Leu Pro Ser Val Leu Ala Gln Glu Ser Val Thr Pro Tyr Ile Ala 
65                  70                  75                  80  


Met Leu Asn Gly Glu Pro Ile Gly Tyr Ala Gln Ser Tyr Val Ala Leu 
                85                  90                  95      


Gly Ser Gly Asp Gly Arg Trp Glu Glu Glu Thr Asp Pro Gly Val Arg 
            100                 105                 110         


Gly Ile Asp Gln Leu Leu Ala Asn Ala Ser Gln Leu Gly Lys Gly Leu 
        115                 120                 125             


Gly Thr Lys Leu Val Arg Ala Leu Val Glu Leu Leu Phe Asn Asp Pro 
    130                 135                 140                 


Glu Val Thr Lys Ile Gln Thr Asp Pro Ser Pro Ser Asn Leu Arg Ala 
145                 150                 155                 160 


Ile Arg Cys Tyr Glu Lys Ala Gly Phe Glu Arg Gln Gly Thr Val Thr 
                165                 170                 175     


Thr Pro Tyr Gly Pro Ala Val Tyr Met Val Gln Thr Arg Gln Ala Phe 
            180                 185                 190         


Glu Arg Thr Arg Ser Asp Ala 
        195                 


<210>  85
<211>  419
<212>  PRT
<213>  Escherichia coli

<400>  85

Met Arg Phe Glu Glu Trp Val Lys Asp Lys His Ile Pro Phe Lys Leu 
1               5                   10                  15      


Asn His Pro Asp Asp Asn Tyr Asp Asp Phe Lys Pro Leu Arg Lys Ile 
            20                  25                  30          


Ile Gly Asp Thr Arg Val Val Ala Leu Gly Glu Asn Ser His Phe Ile 
        35                  40                  45              


Lys Glu Phe Phe Leu Leu Arg His Thr Leu Leu Arg Phe Phe Ile Glu 
    50                  55                  60                  


Asp Leu Gly Phe Thr Thr Phe Ala Phe Glu Phe Gly Phe Ala Glu Gly 
65                  70                  75                  80  


Gln Ile Ile Asn Asn Trp Ile His Gly Gln Gly Thr Asp Asp Glu Ile 
                85                  90                  95      


Gly Arg Phe Leu Lys His Phe Tyr Tyr Pro Glu Glu Leu Lys Thr Thr 
            100                 105                 110         


Phe Leu Trp Leu Arg Glu Tyr Asn Lys Ala Ala Lys Glu Lys Ile Thr 
        115                 120                 125             


Phe Leu Gly Ile Asp Ile Pro Arg Asn Gly Gly Ser Tyr Leu Pro Asn 
    130                 135                 140                 


Met Glu Ile Val His Asp Phe Phe Arg Thr Ala Asp Lys Glu Ala Leu 
145                 150                 155                 160 


His Ile Ile Asp Asp Ala Phe Asn Ile Ala Lys Lys Ile Asp Tyr Phe 
                165                 170                 175     


Ser Thr Ser Gln Ala Ala Leu Asn Leu His Glu Leu Thr Asp Ser Glu 
            180                 185                 190         


Lys Cys Arg Leu Thr Ser Gln Leu Ala Arg Val Lys Val Arg Leu Glu 
        195                 200                 205             


Ala Met Ala Pro Ile His Ile Glu Lys Tyr Gly Ile Asp Lys Tyr Glu 
    210                 215                 220                 


Thr Ile Leu His Tyr Ala Asn Gly Met Ile Tyr Leu Asp Tyr Asn Ile 
225                 230                 235                 240 


Gln Ala Met Ser Gly Phe Ile Ser Gly Gly Gly Met Gln Gly Asp Met 
                245                 250                 255     


Gly Ala Lys Asp Lys Tyr Met Ala Asp Ser Val Leu Trp His Leu Lys 
            260                 265                 270         


Asn Pro Gln Ser Glu Gln Lys Val Ile Val Val Ala His Asn Ala His 
        275                 280                 285             


Ile Gln Lys Thr Pro Ile Leu Tyr Asp Gly Phe Leu Ser Cys Leu Pro 
    290                 295                 300                 


Met Gly Gln Arg Leu Lys Asn Ala Ile Gly Asp Asp Tyr Met Ser Leu 
305                 310                 315                 320 


Gly Ile Thr Ser Tyr Ser Gly His Thr Ala Ala Leu Tyr Pro Glu Val 
                325                 330                 335     


Asp Thr Lys Tyr Gly Phe Arg Val Asp Asn Phe Gln Leu Gln Glu Pro 
            340                 345                 350         


Asn Glu Gly Ser Val Glu Lys Ala Ile Ser Gly Cys Gly Val Thr Asn 
        355                 360                 365             


Ser Phe Val Phe Phe Arg Asn Ile Pro Glu Asp Leu Gln Ser Ile Pro 
    370                 375                 380                 


Asn Met Ile Arg Phe Asp Ser Ile Tyr Met Lys Ala Glu Leu Glu Lys 
385                 390                 395                 400 


Ala Phe Asp Gly Ile Phe Gln Ile Glu Lys Ser Ser Val Ser Glu Val 
                405                 410                 415     


Val Tyr Glu 
            


<210>  86
<211>  388
<212>  PRT
<213>  Bacteroides fragilis

<400>  86

Met Thr Met Arg Ile Asp Thr Asp Lys Gln Met Asn Leu Leu Ser Asp 
1               5                   10                  15      


Lys Asn Val Ala Ile Ile Gly Gly Gly Pro Val Gly Leu Thr Met Ala 
            20                  25                  30          


Lys Leu Leu Gln Gln Asn Gly Ile Asp Val Ser Val Tyr Glu Arg Asp 
        35                  40                  45              


Asn Asp Arg Glu Ala Arg Ile Phe Gly Gly Thr Leu Asp Leu His Lys 
    50                  55                  60                  


Gly Ser Gly Gln Glu Ala Met Lys Lys Ala Gly Leu Leu Gln Thr Tyr 
65                  70                  75                  80  


Tyr Asp Leu Ala Leu Pro Met Gly Val Asn Ile Ala Asp Lys Lys Gly 
                85                  90                  95      


Asn Ile Leu Ser Thr Lys Asn Val Lys Pro Glu Asn Arg Phe Asp Asn 
            100                 105                 110         


Pro Glu Ile Asn Arg Asn Asp Leu Arg Ala Ile Leu Leu Asn Ser Leu 
        115                 120                 125             


Glu Asn Asp Thr Val Ile Trp Asp Arg Lys Leu Val Met Leu Glu Pro 
    130                 135                 140                 


Gly Lys Lys Lys Trp Thr Leu Thr Phe Glu Asn Lys Pro Ser Glu Thr 
145                 150                 155                 160 


Ala Asp Leu Val Ile Leu Ala Asn Gly Gly Met Ser Lys Val Arg Lys 
                165                 170                 175     


Phe Val Thr Asp Thr Glu Val Glu Glu Thr Gly Thr Phe Asn Ile Gln 
            180                 185                 190         


Ala Asp Ile His Gln Pro Glu Ile Asn Cys Pro Gly Phe Phe Gln Leu 
        195                 200                 205             


Cys Asn Gly Asn Arg Leu Met Ala Ser His Gln Gly Asn Leu Leu Phe 
    210                 215                 220                 


Ala Asn Pro Asn Asn Asn Gly Ala Leu His Phe Gly Ile Ser Phe Lys 
225                 230                 235                 240 


Thr Pro Asp Glu Trp Lys Asn Gln Thr Gln Val Asp Phe Gln Asn Arg 
                245                 250                 255     


Asn Ser Val Val Asp Phe Leu Leu Lys Glu Phe Ser Asp Trp Asp Glu 
            260                 265                 270         


Arg Tyr Lys Glu Leu Ile His Thr Thr Leu Ser Phe Val Gly Leu Ala 
        275                 280                 285             


Thr Arg Ile Phe Pro Leu Glu Lys Pro Trp Lys Ser Lys Arg Pro Leu 
    290                 295                 300                 


Pro Ile Thr Met Ile Gly Asp Ala Ala His Leu Met Pro Pro Phe Ala 
305                 310                 315                 320 


Gly Gln Gly Val Asn Ser Gly Leu Val Asp Ala Leu Ile Leu Ser Asp 
                325                 330                 335     


Asn Leu Ala Asp Gly Lys Phe Asn Ser Ile Glu Glu Ala Val Lys Asn 
            340                 345                 350         


Tyr Glu Gln Gln Met Phe Met Tyr Gly Lys Glu Ala Gln Glu Glu Ser 
        355                 360                 365             


Thr Gln Asn Glu Ile Glu Met Phe Lys Pro Asp Phe Thr Phe Gln Gln 
    370                 375                 380                 


Leu Leu Asn Val 
385             


<210>  87
<211>  267
<212>  PRT
<213>  Enterococcus faecium

<400>  87

Met Leu Lys Gln Lys Glu Leu Ile Ala Asn Val Lys Asn Leu Thr Glu 
1               5                   10                  15      


Ser Asp Glu Arg Ile Thr Ala Cys Met Met Tyr Gly Ser Phe Thr Lys 
            20                  25                  30          


Gly Glu Gly Asp Gln Tyr Ser Asp Ile Glu Phe Tyr Ile Phe Leu Lys 
        35                  40                  45              


His Ser Ile Thr Ser Asn Phe Asp Ser Ser Asn Trp Leu Phe Asp Val 
    50                  55                  60                  


Ala Pro Tyr Leu Met Leu Tyr Lys Asn Glu Tyr Gly Thr Glu Val Val 
65                  70                  75                  80  


Ile Phe Asp Asn Leu Ile Arg Gly Glu Phe His Phe Leu Ser Glu Lys 
                85                  90                  95      


Asp Met Asn Ile Ile Pro Ser Phe Lys Asp Ser Gly Tyr Ile Pro Asp 
            100                 105                 110         


Thr Lys Ala Met Leu Ile Tyr Asp Glu Thr Gly Gln Leu Glu Asn Tyr 
        115                 120                 125             


Leu Ser Glu Ile Ser Gly Ala Arg Pro Asn Arg Leu Thr Glu Glu Asn 
    130                 135                 140                 


Ala Asn Phe Leu Leu Cys Asn Phe Ser Asn Leu Trp Leu Met Gly Ile 
145                 150                 155                 160 


Asn Val Leu Lys Arg Gly Glu Tyr Ala Arg Ser Leu Glu Leu Leu Ser 
                165                 170                 175     


Gln Leu Gln Lys Asn Thr Leu Gln Leu Ile Arg Met Ala Glu Lys Asn 
            180                 185                 190         


Ala Asp Asn Trp Leu Asn Met Ser Lys Asn Leu Glu Lys Glu Ile Ser 
        195                 200                 205             


Leu Glu Asn Tyr Lys Lys Phe Ala Lys Thr Thr Ala Arg Leu Asp Lys 
    210                 215                 220                 


Val Glu Leu Phe Glu Ala Tyr Lys Asn Ser Leu Leu Leu Val Met Asp 
225                 230                 235                 240 


Leu Gln Ser His Leu Ile Glu Gln Tyr Asn Leu Lys Val Thr His Asp 
                245                 250                 255     


Ile Leu Glu Arg Leu Leu Asn Tyr Ile Ser Glu 
            260                 265         


<210>  88
<211>  532
<212>  PRT
<213>  artificial

<220>
<223>  TEM36-GGGGGG-CTXM16

<400>  88

His Pro Glu Thr Leu Val Lys Val Lys Asp Ala Glu Asp Gln Leu Gly 
1               5                   10                  15      


Ala Arg Val Gly Tyr Ile Glu Leu Asp Leu Asn Ser Gly Lys Ile Leu 
            20                  25                  30          


Glu Ser Phe Arg Pro Glu Glu Arg Phe Pro Met Val Ser Thr Phe Lys 
        35                  40                  45              


Val Leu Leu Cys Gly Ala Val Leu Ser Arg Val Asp Ala Gly Gln Glu 
    50                  55                  60                  


Gln Leu Gly Arg Arg Ile His Tyr Ser Gln Asn Asp Leu Val Glu Tyr 
65                  70                  75                  80  


Ser Pro Val Thr Glu Lys His Leu Thr Asp Gly Met Thr Val Arg Glu 
                85                  90                  95      


Leu Cys Ser Ala Ala Ile Thr Met Ser Asp Asn Thr Ala Ala Asn Leu 
            100                 105                 110         


Leu Leu Thr Thr Ile Gly Gly Pro Lys Glu Leu Thr Ala Phe Leu His 
        115                 120                 125             


Asn Met Gly Asp His Val Thr Arg Leu Asp Arg Trp Glu Pro Glu Leu 
    130                 135                 140                 


Asn Glu Ala Ile Pro Asn Asp Glu Arg Asp Thr Thr Met Pro Ala Ala 
145                 150                 155                 160 


Met Ala Thr Thr Leu Arg Lys Leu Leu Thr Gly Glu Leu Leu Thr Leu 
                165                 170                 175     


Ala Ser Arg Gln Gln Leu Ile Asp Trp Met Glu Ala Asp Lys Val Ala 
            180                 185                 190         


Gly Pro Leu Leu Arg Ser Ala Leu Pro Ala Gly Trp Phe Ile Ala Asp 
        195                 200                 205             


Lys Ser Gly Ala Gly Glu Arg Gly Ser Arg Gly Ile Ile Ala Ala Leu 
    210                 215                 220                 


Gly Pro Asp Gly Lys Pro Ser Arg Ile Val Val Ile Tyr Thr Thr Gly 
225                 230                 235                 240 


Ser Gln Ala Thr Met Asp Glu Arg Asp Arg Gln Ile Ala Glu Ile Gly 
                245                 250                 255     


Ala Ser Leu Ile Lys His Trp Gly Gly Gly Gly Gly Gly Gln Thr Ser 
            260                 265                 270         


Ala Val Gln Gln Lys Leu Ala Ala Leu Glu Lys Ser Ser Gly Gly Arg 
        275                 280                 285             


Leu Gly Val Ala Leu Ile Asp Thr Ala Asp Asn Thr Gln Val Leu Tyr 
    290                 295                 300                 


Arg Gly Asp Glu Arg Phe Pro Met Cys Ser Thr Ser Lys Val Met Ala 
305                 310                 315                 320 


Ala Ala Ala Val Leu Lys Gln Ser Glu Thr Gln Lys Gln Leu Leu Asn 
                325                 330                 335     


Gln Pro Val Glu Ile Lys Pro Ala Asp Leu Val Asn Tyr Asn Pro Ile 
            340                 345                 350         


Ala Glu Lys His Val Asn Gly Thr Met Thr Leu Ala Glu Leu Ser Ala 
        355                 360                 365             


Ala Ala Leu Gln Tyr Ser Asp Asn Thr Ala Met Asn Lys Leu Ile Ala 
    370                 375                 380                 


Gln Leu Gly Gly Pro Gly Gly Val Thr Ala Phe Ala Arg Ala Ile Gly 
385                 390                 395                 400 


Asp Glu Thr Phe Arg Leu Asp Arg Thr Glu Pro Thr Leu Asn Thr Ala 
                405                 410                 415     


Ile Pro Gly Asp Pro Arg Asp Thr Thr Thr Pro Arg Ala Met Ala Gln 
            420                 425                 430         


Thr Leu Arg Gln Leu Thr Leu Gly His Ala Leu Gly Glu Thr Gln Arg 
        435                 440                 445             


Ala Gln Leu Val Thr Trp Leu Lys Gly Asn Thr Thr Gly Ala Ala Ser 
    450                 455                 460                 


Ile Arg Ala Gly Leu Pro Thr Ser Trp Thr Ala Gly Asp Lys Thr Gly 
465                 470                 475                 480 


Ser Gly Gly Tyr Gly Thr Thr Asn Asp Ile Ala Val Ile Trp Pro Gln 
                485                 490                 495     


Gly Arg Ala Pro Leu Val Leu Val Thr Tyr Phe Thr Gln Pro Gln Gln 
            500                 505                 510         


Asn Ala Glu Ser Arg Arg Asp Val Leu Ala Ser Ala Ala Arg Ile Ile 
        515                 520                 525             


Ala Glu Gly Leu 
    530         


<210>  89
<211>  532
<212>  PRT
<213>  artificial

<220>
<223>  fusion CTXM16-6G-TEM36

<400>  89

Gln Thr Ser Ala Val Gln Gln Lys Leu Ala Ala Leu Glu Lys Ser Ser 
1               5                   10                  15      


Gly Gly Arg Leu Gly Val Ala Leu Ile Asp Thr Ala Asp Asn Thr Gln 
            20                  25                  30          


Val Leu Tyr Arg Gly Asp Glu Arg Phe Pro Met Cys Ser Thr Ser Lys 
        35                  40                  45              


Val Met Ala Ala Ala Ala Val Leu Lys Gln Ser Glu Thr Gln Lys Gln 
    50                  55                  60                  


Leu Leu Asn Gln Pro Val Glu Ile Lys Pro Ala Asp Leu Val Asn Tyr 
65                  70                  75                  80  


Asn Pro Ile Ala Glu Lys His Val Asn Gly Thr Met Thr Leu Ala Glu 
                85                  90                  95      


Leu Ser Ala Ala Ala Leu Gln Tyr Ser Asp Asn Thr Ala Met Asn Lys 
            100                 105                 110         


Leu Ile Ala Gln Leu Gly Gly Pro Gly Gly Val Thr Ala Phe Ala Arg 
        115                 120                 125             


Ala Ile Gly Asp Glu Thr Phe Arg Leu Asp Arg Thr Glu Pro Thr Leu 
    130                 135                 140                 


Asn Thr Ala Ile Pro Gly Asp Pro Arg Asp Thr Thr Thr Pro Arg Ala 
145                 150                 155                 160 


Met Ala Gln Thr Leu Arg Gln Leu Thr Leu Gly His Ala Leu Gly Glu 
                165                 170                 175     


Thr Gln Arg Ala Gln Leu Val Thr Trp Leu Lys Gly Asn Thr Thr Gly 
            180                 185                 190         


Ala Ala Ser Ile Arg Ala Gly Leu Pro Thr Ser Trp Thr Ala Gly Asp 
        195                 200                 205             


Lys Thr Gly Ser Gly Gly Tyr Gly Thr Thr Asn Asp Ile Ala Val Ile 
    210                 215                 220                 


Trp Pro Gln Gly Arg Ala Pro Leu Val Leu Val Thr Tyr Phe Thr Gln 
225                 230                 235                 240 


Pro Gln Gln Asn Ala Glu Ser Arg Arg Asp Val Leu Ala Ser Ala Ala 
                245                 250                 255     


Arg Ile Ile Ala Glu Gly Leu Gly Gly Gly Gly Gly Gly His Pro Glu 
            260                 265                 270         


Thr Leu Val Lys Val Lys Asp Ala Glu Asp Gln Leu Gly Ala Arg Val 
        275                 280                 285             


Gly Tyr Ile Glu Leu Asp Leu Asn Ser Gly Lys Ile Leu Glu Ser Phe 
    290                 295                 300                 


Arg Pro Glu Glu Arg Phe Pro Met Val Ser Thr Phe Lys Val Leu Leu 
305                 310                 315                 320 


Cys Gly Ala Val Leu Ser Arg Val Asp Ala Gly Gln Glu Gln Leu Gly 
                325                 330                 335     


Arg Arg Ile His Tyr Ser Gln Asn Asp Leu Val Glu Tyr Ser Pro Val 
            340                 345                 350         


Thr Glu Lys His Leu Thr Asp Gly Met Thr Val Arg Glu Leu Cys Ser 
        355                 360                 365             


Ala Ala Ile Thr Met Ser Asp Asn Thr Ala Ala Asn Leu Leu Leu Thr 
    370                 375                 380                 


Thr Ile Gly Gly Pro Lys Glu Leu Thr Ala Phe Leu His Asn Met Gly 
385                 390                 395                 400 


Asp His Val Thr Arg Leu Asp Arg Trp Glu Pro Glu Leu Asn Glu Ala 
                405                 410                 415     


Ile Pro Asn Asp Glu Arg Asp Thr Thr Met Pro Ala Ala Met Ala Thr 
            420                 425                 430         


Thr Leu Arg Lys Leu Leu Thr Gly Glu Leu Leu Thr Leu Ala Ser Arg 
        435                 440                 445             


Gln Gln Leu Ile Asp Trp Met Glu Ala Asp Lys Val Ala Gly Pro Leu 
    450                 455                 460                 


Leu Arg Ser Ala Leu Pro Ala Gly Trp Phe Ile Ala Asp Lys Ser Gly 
465                 470                 475                 480 


Ala Gly Glu Arg Gly Ser Arg Gly Ile Ile Ala Ala Leu Gly Pro Asp 
                485                 490                 495     


Gly Lys Pro Ser Arg Ile Val Val Ile Tyr Thr Thr Gly Ser Gln Ala 
            500                 505                 510         


Thr Met Asp Glu Arg Asp Arg Gln Ile Ala Glu Ile Gly Ala Ser Leu 
        515                 520                 525             


Ile Lys His Trp 
    530         


<210>  90
<211>  537
<212>  PRT
<213>  artificial

<220>
<223>  fusion TEM36 - G(EAAAK)2 - CTXM16

<400>  90

His Pro Glu Thr Leu Val Lys Val Lys Asp Ala Glu Asp Gln Leu Gly 
1               5                   10                  15      


Ala Arg Val Gly Tyr Ile Glu Leu Asp Leu Asn Ser Gly Lys Ile Leu 
            20                  25                  30          


Glu Ser Phe Arg Pro Glu Glu Arg Phe Pro Met Val Ser Thr Phe Lys 
        35                  40                  45              


Val Leu Leu Cys Gly Ala Val Leu Ser Arg Val Asp Ala Gly Gln Glu 
    50                  55                  60                  


Gln Leu Gly Arg Arg Ile His Tyr Ser Gln Asn Asp Leu Val Glu Tyr 
65                  70                  75                  80  


Ser Pro Val Thr Glu Lys His Leu Thr Asp Gly Met Thr Val Arg Glu 
                85                  90                  95      


Leu Cys Ser Ala Ala Ile Thr Met Ser Asp Asn Thr Ala Ala Asn Leu 
            100                 105                 110         


Leu Leu Thr Thr Ile Gly Gly Pro Lys Glu Leu Thr Ala Phe Leu His 
        115                 120                 125             


Asn Met Gly Asp His Val Thr Arg Leu Asp Arg Trp Glu Pro Glu Leu 
    130                 135                 140                 


Asn Glu Ala Ile Pro Asn Asp Glu Arg Asp Thr Thr Met Pro Ala Ala 
145                 150                 155                 160 


Met Ala Thr Thr Leu Arg Lys Leu Leu Thr Gly Glu Leu Leu Thr Leu 
                165                 170                 175     


Ala Ser Arg Gln Gln Leu Ile Asp Trp Met Glu Ala Asp Lys Val Ala 
            180                 185                 190         


Gly Pro Leu Leu Arg Ser Ala Leu Pro Ala Gly Trp Phe Ile Ala Asp 
        195                 200                 205             


Lys Ser Gly Ala Gly Glu Arg Gly Ser Arg Gly Ile Ile Ala Ala Leu 
    210                 215                 220                 


Gly Pro Asp Gly Lys Pro Ser Arg Ile Val Val Ile Tyr Thr Thr Gly 
225                 230                 235                 240 


Ser Gln Ala Thr Met Asp Glu Arg Asp Arg Gln Ile Ala Glu Ile Gly 
                245                 250                 255     


Ala Ser Leu Ile Lys His Trp Gly Glu Ala Ala Ala Lys Glu Ala Ala 
            260                 265                 270         


Ala Lys Gln Thr Ser Ala Val Gln Gln Lys Leu Ala Ala Leu Glu Lys 
        275                 280                 285             


Ser Ser Gly Gly Arg Leu Gly Val Ala Leu Ile Asp Thr Ala Asp Asn 
    290                 295                 300                 


Thr Gln Val Leu Tyr Arg Gly Asp Glu Arg Phe Pro Met Cys Ser Thr 
305                 310                 315                 320 


Ser Lys Val Met Ala Ala Ala Ala Val Leu Lys Gln Ser Glu Thr Gln 
                325                 330                 335     


Lys Gln Leu Leu Asn Gln Pro Val Glu Ile Lys Pro Ala Asp Leu Val 
            340                 345                 350         


Asn Tyr Asn Pro Ile Ala Glu Lys His Val Asn Gly Thr Met Thr Leu 
        355                 360                 365             


Ala Glu Leu Ser Ala Ala Ala Leu Gln Tyr Ser Asp Asn Thr Ala Met 
    370                 375                 380                 


Asn Lys Leu Ile Ala Gln Leu Gly Gly Pro Gly Gly Val Thr Ala Phe 
385                 390                 395                 400 


Ala Arg Ala Ile Gly Asp Glu Thr Phe Arg Leu Asp Arg Thr Glu Pro 
                405                 410                 415     


Thr Leu Asn Thr Ala Ile Pro Gly Asp Pro Arg Asp Thr Thr Thr Pro 
            420                 425                 430         


Arg Ala Met Ala Gln Thr Leu Arg Gln Leu Thr Leu Gly His Ala Leu 
        435                 440                 445             


Gly Glu Thr Gln Arg Ala Gln Leu Val Thr Trp Leu Lys Gly Asn Thr 
    450                 455                 460                 


Thr Gly Ala Ala Ser Ile Arg Ala Gly Leu Pro Thr Ser Trp Thr Ala 
465                 470                 475                 480 


Gly Asp Lys Thr Gly Ser Gly Gly Tyr Gly Thr Thr Asn Asp Ile Ala 
                485                 490                 495     


Val Ile Trp Pro Gln Gly Arg Ala Pro Leu Val Leu Val Thr Tyr Phe 
            500                 505                 510         


Thr Gln Pro Gln Gln Asn Ala Glu Ser Arg Arg Asp Val Leu Ala Ser 
        515                 520                 525             


Ala Ala Arg Ile Ile Ala Glu Gly Leu 
    530                 535         


