                               SEQUENCE LISTING

<110> JANSSEN VACCINES & PREVENTION B.V.
 
<120> STABILIZED FILOVIRUS GLYCOPROTEIN TRIMERS

<130> 0315 EP P00 PRI

<140> EP 18188675.5
<141> 2018-09-28

<160> 46    

<170> PatentIn version 3.5

<210> 1
<211> 676
<212> PRT
<213> Zaire ebolavirus

<400> 1
Met Gly Val Thr Gly Ile Leu Gln Leu Pro Arg Asp Arg Phe Lys Arg 
1               5                   10                  15      


Thr Ser Phe Phe Leu Trp Val Ile Ile Leu Phe Gln Arg Thr Phe Ser 
            20                  25                  30          


Ile Pro Leu Gly Val Ile His Asn Ser Thr Leu Gln Val Ser Asp Val 
        35                  40                  45              


Asp Lys Leu Val Cys Arg Asp Lys Leu Ser Ser Thr Asn Gln Leu Arg 
    50                  55                  60                  


Ser Val Gly Leu Asn Leu Glu Gly Asn Gly Val Ala Thr Asp Val Pro 
65                  70                  75                  80  


Ser Ala Thr Lys Arg Trp Gly Phe Arg Ser Gly Val Pro Pro Lys Val 
                85                  90                  95      


Val Asn Tyr Glu Ala Gly Glu Trp Ala Glu Asn Cys Tyr Asn Leu Glu 
            100                 105                 110         


Ile Lys Lys Pro Asp Gly Ser Glu Cys Leu Pro Ala Ala Pro Asp Gly 
        115                 120                 125             


Ile Arg Gly Phe Pro Arg Cys Arg Tyr Val His Lys Val Ser Gly Thr 
    130                 135                 140                 


Gly Pro Cys Ala Gly Asp Phe Ala Phe His Lys Glu Gly Ala Phe Phe 
145                 150                 155                 160 


Leu Tyr Asp Arg Leu Ala Ser Thr Val Ile Tyr Arg Gly Thr Thr Phe 
                165                 170                 175     


Ala Glu Gly Val Val Ala Phe Leu Ile Leu Pro Gln Ala Lys Lys Asp 
            180                 185                 190         


Phe Phe Ser Ser His Pro Leu Arg Glu Pro Val Asn Ala Thr Glu Asp 
        195                 200                 205             


Pro Ser Ser Gly Tyr Tyr Ser Thr Thr Ile Arg Tyr Gln Ala Thr Gly 
    210                 215                 220                 


Phe Gly Thr Asn Glu Thr Glu Tyr Leu Phe Glu Val Asp Asn Leu Thr 
225                 230                 235                 240 


Tyr Val Gln Leu Glu Ser Arg Phe Thr Pro Gln Phe Leu Leu Gln Leu 
                245                 250                 255     


Asn Glu Thr Ile Tyr Thr Ser Gly Lys Arg Ser Asn Thr Thr Gly Lys 
            260                 265                 270         


Leu Ile Trp Lys Val Asn Pro Glu Ile Asp Thr Thr Ile Gly Glu Trp 
        275                 280                 285             


Ala Phe Trp Glu Thr Lys Lys Asn Leu Thr Arg Lys Ile Arg Ser Glu 
    290                 295                 300                 


Glu Leu Ser Phe Thr Val Val Ser Asn Gly Ala Lys Asn Ile Ser Gly 
305                 310                 315                 320 


Gln Ser Pro Ala Arg Thr Ser Ser Asp Pro Gly Thr Asn Thr Thr Thr 
                325                 330                 335     


Glu Asp His Lys Ile Met Ala Ser Glu Asn Ser Ser Ala Met Val Gln 
            340                 345                 350         


Val His Ser Gln Gly Arg Glu Ala Ala Val Ser His Leu Thr Thr Leu 
        355                 360                 365             


Ala Thr Ile Ser Thr Ser Pro Gln Ser Leu Thr Thr Lys Pro Gly Pro 
    370                 375                 380                 


Asp Asn Ser Thr His Asn Thr Pro Val Tyr Lys Leu Asp Ile Ser Glu 
385                 390                 395                 400 


Ala Thr Gln Val Glu Gln His His Arg Arg Thr Asp Asn Asp Ser Thr 
                405                 410                 415     


Ala Ser Asp Thr Pro Ser Ala Thr Thr Ala Ala Gly Pro Pro Lys Ala 
            420                 425                 430         


Glu Asn Thr Asn Thr Ser Lys Ser Thr Asp Phe Leu Asp Pro Ala Thr 
        435                 440                 445             


Thr Thr Ser Pro Gln Asn His Ser Glu Thr Ala Gly Asn Asn Asn Thr 
    450                 455                 460                 


His His Gln Asp Thr Gly Glu Glu Ser Ala Ser Ser Gly Lys Leu Gly 
465                 470                 475                 480 


Leu Ile Thr Asn Thr Ile Ala Gly Val Ala Gly Leu Ile Thr Gly Gly 
                485                 490                 495     


Arg Arg Thr Arg Arg Glu Ala Ile Val Asn Ala Gln Pro Lys Cys Asn 
            500                 505                 510         


Pro Asn Leu His Tyr Trp Thr Thr Gln Asp Glu Gly Ala Ala Ile Gly 
        515                 520                 525             


Leu Ala Trp Ile Pro Tyr Phe Gly Pro Ala Ala Glu Gly Ile Tyr Ile 
    530                 535                 540                 


Glu Gly Leu Met His Asn Gln Asp Gly Leu Ile Cys Gly Leu Arg Gln 
545                 550                 555                 560 


Leu Ala Asn Glu Thr Thr Gln Ala Leu Gln Leu Phe Leu Arg Ala Thr 
                565                 570                 575     


Thr Glu Leu Arg Thr Phe Ser Ile Leu Asn Arg Lys Ala Ile Asp Phe 
            580                 585                 590         


Leu Leu Gln Arg Trp Gly Gly Thr Cys His Ile Leu Gly Pro Asp Cys 
        595                 600                 605             


Cys Ile Glu Pro His Asp Trp Thr Lys Asn Ile Thr Asp Lys Ile Asp 
    610                 615                 620                 


Gln Ile Ile His Asp Phe Val Asp Lys Thr Leu Pro Asp Gln Gly Asp 
625                 630                 635                 640 


Asn Asp Asn Trp Trp Thr Gly Trp Arg Gln Trp Ile Pro Ala Gly Ile 
                645                 650                 655     


Gly Val Thr Gly Val Ile Ile Ala Val Ile Ala Leu Phe Cys Ile Cys 
            660                 665                 670         


Lys Phe Val Phe 
        675     


<210> 2
<211> 615
<212> PRT
<213> Zaire ebolavirus

<400> 2
Ile Pro Leu Gly Val Ile His Asn Ser Thr Leu Gln Val Ser Asp Val 
1               5                   10                  15      


Asp Lys Leu Val Cys Arg Asp Lys Leu Ser Ser Thr Asn Gln Leu Arg 
            20                  25                  30          


Ser Val Gly Leu Asn Leu Glu Gly Asn Gly Val Ala Thr Asp Val Pro 
        35                  40                  45              


Ser Ala Thr Lys Arg Trp Gly Phe Arg Ser Gly Val Pro Pro Lys Val 
    50                  55                  60                  


Val Asn Tyr Glu Ala Gly Glu Trp Ala Glu Asn Cys Tyr Asn Leu Glu 
65                  70                  75                  80  


Ile Lys Lys Pro Asp Gly Ser Glu Cys Leu Pro Ala Ala Pro Asp Gly 
                85                  90                  95      


Ile Arg Gly Phe Pro Arg Cys Arg Tyr Val His Lys Val Ser Gly Thr 
            100                 105                 110         


Gly Pro Cys Ala Gly Asp Phe Ala Phe His Lys Glu Gly Ala Phe Phe 
        115                 120                 125             


Leu Tyr Asp Arg Leu Ala Ser Thr Val Ile Tyr Arg Gly Thr Thr Phe 
    130                 135                 140                 


Ala Glu Gly Val Val Ala Phe Leu Ile Leu Pro Gln Ala Lys Lys Asp 
145                 150                 155                 160 


Phe Phe Ser Ser His Pro Leu Arg Glu Pro Val Asn Ala Thr Glu Asp 
                165                 170                 175     


Pro Ser Ser Gly Tyr Tyr Ser Thr Thr Ile Arg Tyr Gln Ala Thr Gly 
            180                 185                 190         


Phe Gly Thr Asn Glu Thr Glu Tyr Leu Phe Glu Val Asp Asn Leu Thr 
        195                 200                 205             


Tyr Val Gln Leu Glu Ser Arg Phe Thr Pro Gln Phe Leu Leu Gln Leu 
    210                 215                 220                 


Asn Glu Thr Ile Tyr Thr Ser Gly Lys Arg Ser Asn Thr Thr Gly Lys 
225                 230                 235                 240 


Leu Ile Trp Lys Val Asn Pro Glu Ile Asp Thr Thr Ile Gly Glu Trp 
                245                 250                 255     


Ala Phe Trp Glu Thr Lys Lys Asn Leu Thr Arg Lys Ile Arg Ser Glu 
            260                 265                 270         


Glu Leu Ser Phe Thr Val Val Ser Asn Gly Ala Lys Asn Ile Ser Gly 
        275                 280                 285             


Gln Ser Pro Ala Arg Thr Ser Ser Asp Pro Gly Thr Asn Thr Thr Thr 
    290                 295                 300                 


Glu Asp His Lys Ile Met Ala Ser Glu Asn Ser Ser Ala Met Val Gln 
305                 310                 315                 320 


Val His Ser Gln Gly Arg Glu Ala Ala Val Ser His Leu Thr Thr Leu 
                325                 330                 335     


Ala Thr Ile Ser Thr Ser Pro Gln Ser Leu Thr Thr Lys Pro Gly Pro 
            340                 345                 350         


Asp Asn Ser Thr His Asn Thr Pro Val Tyr Lys Leu Asp Ile Ser Glu 
        355                 360                 365             


Ala Thr Gln Val Glu Gln His His Arg Arg Thr Asp Asn Asp Ser Thr 
    370                 375                 380                 


Ala Ser Asp Thr Pro Ser Ala Thr Thr Ala Ala Gly Pro Pro Lys Ala 
385                 390                 395                 400 


Glu Asn Thr Asn Thr Ser Lys Ser Thr Asp Phe Leu Asp Pro Ala Thr 
                405                 410                 415     


Thr Thr Ser Pro Gln Asn His Ser Glu Thr Ala Gly Asn Asn Asn Thr 
            420                 425                 430         


His His Gln Asp Thr Gly Glu Glu Ser Ala Ser Ser Gly Lys Leu Gly 
        435                 440                 445             


Leu Ile Thr Asn Thr Ile Ala Gly Val Ala Gly Leu Ile Thr Gly Gly 
    450                 455                 460                 


Arg Arg Thr Arg Arg Glu Ala Ile Val Asn Ala Gln Pro Lys Cys Asn 
465                 470                 475                 480 


Pro Asn Leu His Tyr Trp Thr Thr Gln Asp Glu Gly Ala Ala Ile Gly 
                485                 490                 495     


Leu Ala Trp Ile Pro Tyr Phe Gly Pro Ala Ala Glu Gly Ile Tyr Ile 
            500                 505                 510         


Glu Gly Leu Met His Asn Gln Asp Gly Leu Ile Cys Gly Leu Arg Gln 
        515                 520                 525             


Leu Ala Asn Glu Thr Thr Gln Ala Leu Gln Leu Phe Leu Arg Ala Thr 
    530                 535                 540                 


Thr Glu Leu Arg Thr Phe Ser Ile Leu Asn Arg Lys Ala Ile Asp Phe 
545                 550                 555                 560 


Leu Leu Gln Arg Trp Gly Gly Thr Cys His Ile Leu Gly Pro Asp Cys 
                565                 570                 575     


Cys Ile Glu Pro His Asp Trp Thr Lys Asn Ile Thr Asp Lys Ile Asp 
            580                 585                 590         


Gln Ile Ile His Asp Phe Val Asp Lys Thr Leu Pro Asp Gln Gly Asp 
        595                 600                 605             


Asn Asp Asn Trp Trp Thr Gly 
    610                 615 


<210> 3
<211> 615
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 3
Ile Pro Leu Gly Val Ile His Asn Ser Thr Leu Gln Val Ser Asp Val 
1               5                   10                  15      


Asp Lys Leu Val Cys Arg Asp Lys Leu Ser Ser Thr Asn Gln Leu Arg 
            20                  25                  30          


Ser Val Gly Leu Asn Leu Glu Gly Asn Gly Val Ala Thr Asp Val Pro 
        35                  40                  45              


Ser Ala Thr Lys Arg Trp Gly Phe Arg Ser Gly Val Pro Pro Lys Val 
    50                  55                  60                  


Val Asn Tyr Glu Ala Gly Glu Trp Ala Glu Asn Cys Tyr Asn Leu Glu 
65                  70                  75                  80  


Ile Lys Lys Pro Asp Gly Ser Glu Cys Leu Pro Ala Ala Pro Asp Gly 
                85                  90                  95      


Ile Arg Gly Phe Pro Arg Cys Arg Tyr Val His Lys Val Ser Gly Thr 
            100                 105                 110         


Gly Pro Cys Ala Gly Asp Phe Ala Phe His Lys Glu Gly Ala Phe Phe 
        115                 120                 125             


Leu Tyr Asp Arg Leu Ala Ser Thr Val Ile Tyr Arg Gly Thr Thr Phe 
    130                 135                 140                 


Ala Glu Gly Val Val Ala Phe Leu Ile Leu Pro Gln Ala Lys Lys Asp 
145                 150                 155                 160 


Phe Phe Ser Ser His Pro Leu Arg Glu Pro Val Asn Ala Thr Glu Asp 
                165                 170                 175     


Pro Ser Ser Gly Tyr Tyr Ser Thr Thr Ile Arg Tyr Gln Ala Thr Gly 
            180                 185                 190         


Phe Gly Thr Asn Glu Thr Glu Tyr Leu Phe Glu Val Asp Asn Leu Thr 
        195                 200                 205             


Tyr Val Gln Leu Glu Ser Arg Phe Thr Pro Gln Phe Leu Leu Gln Leu 
    210                 215                 220                 


Asn Glu Thr Ile Tyr Thr Ser Gly Lys Arg Ser Asn Thr Thr Gly Lys 
225                 230                 235                 240 


Leu Ile Trp Lys Val Asn Pro Glu Ile Asp Thr Thr Ile Gly Glu Trp 
                245                 250                 255     


Ala Phe Trp Glu Thr Lys Lys Asn Leu Thr Arg Lys Ile Arg Ser Glu 
            260                 265                 270         


Glu Leu Ser Phe Thr Val Val Ser Asn Gly Ala Lys Asn Ile Ser Gly 
        275                 280                 285             


Gln Ser Pro Ala Arg Thr Ser Ser Asp Pro Gly Thr Asn Thr Thr Thr 
    290                 295                 300                 


Glu Asp His Lys Ile Met Ala Ser Glu Asn Ser Ser Ala Met Val Gln 
305                 310                 315                 320 


Val His Ser Gln Gly Arg Glu Ala Ala Val Ser His Leu Thr Thr Leu 
                325                 330                 335     


Ala Thr Ile Ser Thr Ser Pro Gln Ser Leu Thr Thr Lys Pro Gly Pro 
            340                 345                 350         


Asp Asn Ser Thr His Asn Thr Pro Val Tyr Lys Leu Asp Ile Ser Glu 
        355                 360                 365             


Ala Thr Gln Val Glu Gln His His Arg Arg Thr Asp Asn Asp Ser Thr 
    370                 375                 380                 


Ala Ser Asp Thr Pro Ser Ala Thr Thr Ala Ala Gly Pro Pro Lys Ala 
385                 390                 395                 400 


Glu Asn Thr Asn Thr Ser Lys Ser Thr Asp Phe Leu Asp Pro Ala Thr 
                405                 410                 415     


Thr Thr Ser Pro Gln Asn His Ser Glu Thr Ala Gly Asn Asn Asn Thr 
            420                 425                 430         


His His Gln Asp Thr Gly Glu Glu Ser Ala Ser Ser Gly Lys Leu Gly 
        435                 440                 445             


Leu Ile Thr Asn Thr Ile Ala Gly Val Ala Gly Leu Ile Thr Gly Gly 
    450                 455                 460                 


Arg Arg Thr Arg Arg Glu Ala Ile Val Asn Ala Gln Pro Lys Cys Asn 
465                 470                 475                 480 


Pro Asn Leu His Tyr Trp Thr Thr Gln Asp Glu Gly Ala Ala Ile Gly 
                485                 490                 495     


Leu Ala Trp Ile Pro Tyr Phe Gly Pro Ala Ala Glu Gly Ile Tyr Ile 
            500                 505                 510         


Glu Gly Leu Met His Asn Gln Asp Gly Leu Ile Cys Gly Leu Arg Gln 
        515                 520                 525             


Leu Ala Asn Glu Thr Thr Gln Ala Leu Gln Leu Phe Leu Arg Ala Thr 
    530                 535                 540                 


Pro Glu Leu Arg Thr Phe Ser Ile Leu Asn Arg Lys Ala Ile Asp Phe 
545                 550                 555                 560 


Leu Leu Gln Arg Trp Gly Gly Thr Cys His Ile Leu Gly Pro Asp Cys 
                565                 570                 575     


Cys Ile Glu Pro His Asp Trp Thr Lys Asn Ile Thr Asp Lys Ile Asp 
            580                 585                 590         


Gln Ile Ile His Asp Phe Val Asp Lys Thr Leu Pro Asp Gln Gly Asp 
        595                 600                 605             


Asn Asp Asn Trp Trp Thr Gly 
    610                 615 


<210> 4
<211> 615
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 4
Ile Pro Leu Gly Val Ile His Asn Ser Thr Leu Gln Val Ser Asp Val 
1               5                   10                  15      


Asp Lys Leu Val Cys Arg Asp Lys Leu Ser Ser Thr Asn Gln Leu Arg 
            20                  25                  30          


Ser Val Gly Leu Asn Leu Glu Gly Asn Gly Val Ala Thr Asp Val Pro 
        35                  40                  45              


Ser Ala Thr Lys Arg Trp Gly Phe Arg Ser Gly Val Pro Pro Lys Val 
    50                  55                  60                  


Val Asn Tyr Glu Ala Gly Glu Trp Ala Glu Asn Cys Tyr Asn Leu Glu 
65                  70                  75                  80  


Ile Lys Lys Pro Asp Gly Ser Glu Cys Leu Pro Ala Ala Pro Asp Gly 
                85                  90                  95      


Ile Arg Gly Phe Pro Arg Cys Arg Tyr Val His Lys Val Ser Gly Thr 
            100                 105                 110         


Gly Pro Cys Ala Gly Asp Phe Ala Phe His Lys Glu Gly Ala Phe Phe 
        115                 120                 125             


Leu Tyr Asp Arg Leu Ala Ser Thr Val Ile Tyr Arg Gly Thr Thr Phe 
    130                 135                 140                 


Ala Glu Gly Val Val Ala Phe Leu Ile Leu Pro Gln Ala Lys Lys Asp 
145                 150                 155                 160 


Phe Phe Ser Ser His Pro Leu Arg Glu Pro Val Asn Ala Thr Glu Asp 
                165                 170                 175     


Pro Ser Ser Gly Tyr Tyr Ser Thr Thr Ile Arg Tyr Gln Ala Thr Gly 
            180                 185                 190         


Phe Gly Thr Asn Glu Thr Glu Tyr Leu Phe Glu Val Asp Asn Leu Thr 
        195                 200                 205             


Tyr Val Gln Leu Glu Ser Arg Phe Thr Pro Gln Phe Leu Leu Gln Leu 
    210                 215                 220                 


Asn Glu Thr Ile Tyr Thr Ser Gly Lys Arg Ser Asn Thr Thr Gly Lys 
225                 230                 235                 240 


Leu Ile Trp Lys Val Asn Pro Glu Ile Asp Thr Thr Ile Gly Glu Trp 
                245                 250                 255     


Ala Phe Trp Glu Thr Lys Lys Asn Leu Thr Arg Lys Ile Arg Ser Glu 
            260                 265                 270         


Glu Leu Ser Phe Thr Val Val Ser Asn Gly Ala Lys Asn Ile Ser Gly 
        275                 280                 285             


Gln Ser Pro Ala Arg Thr Ser Ser Asp Pro Gly Thr Asn Thr Thr Thr 
    290                 295                 300                 


Glu Asp His Lys Ile Met Ala Ser Glu Asn Ser Ser Ala Met Val Gln 
305                 310                 315                 320 


Val His Ser Gln Gly Arg Glu Ala Ala Val Ser His Leu Thr Thr Leu 
                325                 330                 335     


Ala Thr Ile Ser Thr Ser Pro Gln Ser Leu Thr Thr Lys Pro Gly Pro 
            340                 345                 350         


Asp Asn Ser Thr His Asn Thr Pro Val Tyr Lys Leu Asp Ile Ser Glu 
        355                 360                 365             


Ala Thr Gln Val Glu Gln His His Arg Arg Thr Asp Asn Asp Ser Thr 
    370                 375                 380                 


Ala Ser Asp Thr Pro Ser Ala Thr Thr Ala Ala Gly Pro Pro Lys Ala 
385                 390                 395                 400 


Glu Asn Thr Asn Thr Ser Lys Ser Thr Asp Phe Leu Asp Pro Ala Thr 
                405                 410                 415     


Thr Thr Ser Pro Gln Asn His Ser Glu Thr Ala Gly Asn Asn Asn Thr 
            420                 425                 430         


His His Gln Asp Thr Gly Glu Glu Ser Ala Ser Ser Gly Lys Leu Gly 
        435                 440                 445             


Leu Ile Thr Asn Thr Ile Ala Gly Val Ala Gly Leu Ile Thr Gly Gly 
    450                 455                 460                 


Arg Arg Thr Arg Arg Glu Ala Ile Val Asn Ala Gln Pro Lys Cys Asn 
465                 470                 475                 480 


Pro Asn Leu His Tyr Trp Thr Thr Gln Asp Glu Gly Ala Ala Ile Gly 
                485                 490                 495     


Leu Ala Trp Ile Pro Tyr Phe Gly Pro Ala Ala Glu Gly Ile Tyr Ile 
            500                 505                 510         


Glu Gly Leu Met His Asn Gln Asp Gly Leu Ile Cys Gly Leu Arg Gln 
        515                 520                 525             


Leu Ala Asn Glu Thr Thr Gln Ala Leu Gln Leu Phe Leu Arg Ala Thr 
    530                 535                 540                 


Thr Glu Leu Arg Thr Phe Ser Ile Leu Asn Arg Phe Ala Ile Asp Phe 
545                 550                 555                 560 


Leu Leu Gln Arg Trp Gly Gly Thr Cys His Ile Leu Gly Pro Asp Cys 
                565                 570                 575     


Cys Ile Glu Pro His Asp Trp Thr Lys Asn Ile Thr Asp Lys Ile Asp 
            580                 585                 590         


Gln Ile Ile His Asp Phe Val Asp Lys Thr Leu Pro Asp Gln Gly Asp 
        595                 600                 605             


Asn Asp Asn Trp Trp Thr Gly 
    610                 615 


<210> 5
<211> 615
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 5
Ile Pro Leu Gly Val Ile His Asn Ser Thr Leu Gln Val Ser Asp Val 
1               5                   10                  15      


Asp Lys Leu Val Cys Arg Asp Lys Leu Ser Ser Thr Asn Gln Leu Arg 
            20                  25                  30          


Ser Val Gly Leu Asn Leu Glu Gly Asn Gly Val Ala Thr Asp Val Pro 
        35                  40                  45              


Ser Ala Thr Lys Arg Trp Gly Phe Arg Ser Gly Val Pro Pro Lys Val 
    50                  55                  60                  


Val Asn Tyr Glu Ala Gly Glu Trp Ala Glu Asn Cys Tyr Asn Leu Glu 
65                  70                  75                  80  


Ile Lys Lys Pro Asp Gly Ser Glu Cys Leu Pro Ala Ala Pro Asp Gly 
                85                  90                  95      


Ile Arg Gly Phe Pro Arg Cys Arg Tyr Val His Lys Val Ser Gly Thr 
            100                 105                 110         


Gly Pro Cys Ala Gly Asp Phe Ala Phe His Lys Glu Gly Ala Phe Phe 
        115                 120                 125             


Leu Tyr Asp Arg Leu Ala Ser Thr Val Ile Tyr Arg Gly Thr Thr Phe 
    130                 135                 140                 


Ala Glu Gly Val Val Ala Phe Leu Ile Leu Pro Gln Ala Lys Lys Asp 
145                 150                 155                 160 


Phe Phe Ser Ser His Pro Leu Arg Glu Pro Val Asn Ala Thr Glu Asp 
                165                 170                 175     


Pro Ser Ser Gly Tyr Tyr Ser Thr Thr Ile Arg Tyr Gln Ala Thr Gly 
            180                 185                 190         


Phe Gly Thr Asn Glu Thr Glu Tyr Leu Phe Glu Val Asp Asn Leu Thr 
        195                 200                 205             


Tyr Val Gln Leu Glu Ser Arg Phe Thr Pro Gln Phe Leu Leu Gln Leu 
    210                 215                 220                 


Asn Glu Thr Ile Tyr Thr Ser Gly Lys Arg Ser Asn Thr Thr Gly Lys 
225                 230                 235                 240 


Leu Ile Trp Lys Val Asn Pro Glu Ile Asp Thr Thr Ile Gly Glu Trp 
                245                 250                 255     


Ala Phe Trp Glu Thr Lys Lys Asn Leu Thr Arg Lys Ile Arg Ser Glu 
            260                 265                 270         


Glu Leu Ser Phe Thr Val Val Ser Asn Gly Ala Lys Asn Ile Ser Gly 
        275                 280                 285             


Gln Ser Pro Ala Arg Thr Ser Ser Asp Pro Gly Thr Asn Thr Thr Thr 
    290                 295                 300                 


Glu Asp His Lys Ile Met Ala Ser Glu Asn Ser Ser Ala Met Val Gln 
305                 310                 315                 320 


Val His Ser Gln Gly Arg Glu Ala Ala Val Ser His Leu Thr Thr Leu 
                325                 330                 335     


Ala Thr Ile Ser Thr Ser Pro Gln Ser Leu Thr Thr Lys Pro Gly Pro 
            340                 345                 350         


Asp Asn Ser Thr His Asn Thr Pro Val Tyr Lys Leu Asp Ile Ser Glu 
        355                 360                 365             


Ala Thr Gln Val Glu Gln His His Arg Arg Thr Asp Asn Asp Ser Thr 
    370                 375                 380                 


Ala Ser Asp Thr Pro Ser Ala Thr Thr Ala Ala Gly Pro Pro Lys Ala 
385                 390                 395                 400 


Glu Asn Thr Asn Thr Ser Lys Ser Thr Asp Phe Leu Asp Pro Ala Thr 
                405                 410                 415     


Thr Thr Ser Pro Gln Asn His Ser Glu Thr Ala Gly Asn Asn Asn Thr 
            420                 425                 430         


His His Gln Asp Thr Gly Glu Glu Ser Ala Ser Ser Gly Lys Leu Gly 
        435                 440                 445             


Leu Ile Thr Asn Thr Ile Ala Gly Val Ala Gly Leu Ile Thr Gly Gly 
    450                 455                 460                 


Arg Arg Thr Arg Arg Glu Ala Ile Val Asn Ala Gln Pro Lys Cys Asn 
465                 470                 475                 480 


Pro Asn Leu His Tyr Trp Thr Thr Gln Asp Glu Gly Ala Ala Ile Gly 
                485                 490                 495     


Leu Ala Trp Ile Pro Tyr Phe Gly Pro Ala Ala Glu Gly Ile Tyr Ile 
            500                 505                 510         


Glu Gly Leu Met His Asn Gln Asp Gly Leu Ile Cys Gly Leu Arg Gln 
        515                 520                 525             


Leu Ala Asn Glu Thr Thr Gln Ala Leu Gln Leu Phe Leu Arg Ala Thr 
    530                 535                 540                 


Pro Glu Leu Arg Thr Phe Ser Ile Leu Asn Arg Lys Ala Ile Asp Phe 
545                 550                 555                 560 


Leu Leu Gln Arg Trp Gly Gly Thr Cys His Ile Leu Gly Pro Asp Cys 
                565                 570                 575     


Cys Ile Glu Pro His Asp Trp Thr Lys Asn Ile Thr Asp Lys Ile Asp 
            580                 585                 590         


Gln Ile Ile His Asp Phe Val Asp Lys Thr Leu Pro Asp Gln Gly Asp 
        595                 600                 605             


Asn Asp Asn Trp Trp Thr Gly 
    610                 615 


<210> 6
<211> 458
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 6
Ile Pro Leu Gly Val Ile His Asn Ser Thr Leu Gln Val Ser Asp Val 
1               5                   10                  15      


Asp Lys Leu Val Cys Arg Asp Lys Leu Ser Ser Thr Asn Gln Leu Arg 
            20                  25                  30          


Ser Val Gly Leu Asn Leu Glu Gly Asn Gly Val Ala Thr Asp Val Pro 
        35                  40                  45              


Ser Ala Thr Lys Arg Trp Gly Phe Arg Ser Gly Val Pro Pro Lys Val 
    50                  55                  60                  


Val Asn Tyr Glu Ala Gly Glu Trp Ala Glu Asn Cys Tyr Asn Leu Glu 
65                  70                  75                  80  


Ile Lys Lys Pro Asp Gly Ser Glu Cys Leu Pro Ala Ala Pro Asp Gly 
                85                  90                  95      


Ile Arg Gly Phe Pro Arg Cys Arg Tyr Val His Lys Val Ser Gly Thr 
            100                 105                 110         


Gly Pro Cys Ala Gly Asp Phe Ala Phe His Lys Glu Gly Ala Phe Phe 
        115                 120                 125             


Leu Tyr Asp Arg Leu Ala Ser Thr Val Ile Tyr Arg Gly Thr Thr Phe 
    130                 135                 140                 


Ala Glu Gly Val Val Ala Phe Leu Ile Leu Pro Gln Ala Lys Lys Asp 
145                 150                 155                 160 


Phe Phe Ser Ser His Pro Leu Arg Glu Pro Val Asn Ala Thr Glu Asp 
                165                 170                 175     


Pro Ser Ser Gly Tyr Tyr Ser Thr Thr Ile Arg Tyr Gln Ala Thr Gly 
            180                 185                 190         


Phe Gly Thr Asn Glu Thr Glu Tyr Leu Phe Glu Val Asp Asn Leu Thr 
        195                 200                 205             


Tyr Val Gln Leu Glu Ser Arg Phe Thr Pro Gln Phe Leu Leu Gln Leu 
    210                 215                 220                 


Asn Glu Thr Ile Tyr Thr Ser Gly Lys Arg Ser Asn Thr Thr Gly Lys 
225                 230                 235                 240 


Leu Ile Trp Lys Val Asn Pro Glu Ile Asp Thr Thr Ile Gly Glu Trp 
                245                 250                 255     


Ala Phe Trp Glu Thr Lys Lys Asn Leu Thr Arg Lys Ile Arg Ser Glu 
            260                 265                 270         


Glu Leu Ser Phe Thr Val Val Ser Asn Gly Ala Lys Asn Ile Ser Gly 
        275                 280                 285             


Lys Leu Gly Leu Ile Thr Asn Thr Ile Ala Gly Val Ala Gly Leu Ile 
    290                 295                 300                 


Thr Gly Gly Arg Arg Thr Arg Arg Glu Ala Ile Val Asn Ala Gln Pro 
305                 310                 315                 320 


Lys Cys Asn Pro Asn Leu His Tyr Trp Thr Thr Gln Asp Glu Gly Ala 
                325                 330                 335     


Ala Ile Gly Leu Ala Trp Ile Pro Tyr Phe Gly Pro Ala Ala Glu Gly 
            340                 345                 350         


Ile Tyr Ile Glu Gly Leu Met His Asn Gln Asp Gly Leu Ile Cys Gly 
        355                 360                 365             


Leu Arg Gln Leu Ala Asn Glu Thr Thr Gln Ala Leu Gln Leu Phe Leu 
    370                 375                 380                 


Arg Ala Thr Thr Glu Leu Arg Thr Phe Ser Ile Leu Asn Arg Lys Ala 
385                 390                 395                 400 


Ile Asp Phe Leu Leu Gln Arg Trp Gly Gly Thr Cys His Ile Leu Gly 
                405                 410                 415     


Pro Asp Cys Cys Ile Glu Pro His Asp Trp Thr Lys Asn Ile Thr Asp 
            420                 425                 430         


Lys Ile Asp Gln Ile Ile His Asp Phe Val Asp Lys Thr Leu Pro Asp 
        435                 440                 445             


Gln Gly Asp Asn Asp Asn Trp Trp Thr Gly 
    450                 455             


<210> 7
<211> 458
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 7
Ile Pro Leu Gly Val Ile His Asn Ser Thr Leu Gln Val Ser Asp Val 
1               5                   10                  15      


Asp Lys Leu Val Cys Arg Asp Lys Leu Ser Ser Thr Asn Gln Leu Arg 
            20                  25                  30          


Ser Val Gly Leu Asn Leu Glu Gly Asn Gly Val Ala Thr Asp Val Pro 
        35                  40                  45              


Ser Ala Thr Lys Arg Trp Gly Phe Arg Ser Gly Val Pro Pro Lys Val 
    50                  55                  60                  


Val Asn Tyr Glu Ala Gly Glu Trp Ala Glu Asn Cys Tyr Asn Leu Glu 
65                  70                  75                  80  


Ile Lys Lys Pro Asp Gly Ser Glu Cys Leu Pro Ala Ala Pro Asp Gly 
                85                  90                  95      


Ile Arg Gly Phe Pro Arg Cys Arg Tyr Val His Lys Val Ser Gly Thr 
            100                 105                 110         


Gly Pro Cys Ala Gly Asp Phe Ala Phe His Lys Glu Gly Ala Phe Phe 
        115                 120                 125             


Leu Tyr Asp Arg Leu Ala Ser Thr Val Ile Tyr Arg Gly Thr Thr Phe 
    130                 135                 140                 


Ala Glu Gly Val Val Ala Phe Leu Ile Leu Pro Gln Ala Lys Lys Asp 
145                 150                 155                 160 


Phe Phe Ser Ser His Pro Leu Arg Glu Pro Val Asn Ala Thr Glu Asp 
                165                 170                 175     


Pro Ser Ser Gly Tyr Tyr Ser Thr Thr Ile Arg Tyr Gln Ala Thr Gly 
            180                 185                 190         


Phe Gly Thr Asn Glu Thr Glu Tyr Leu Phe Glu Val Asp Asn Leu Thr 
        195                 200                 205             


Tyr Val Gln Leu Glu Ser Arg Phe Thr Pro Gln Phe Leu Leu Gln Leu 
    210                 215                 220                 


Asn Glu Thr Ile Tyr Thr Ser Gly Lys Arg Ser Asn Thr Thr Gly Lys 
225                 230                 235                 240 


Leu Ile Trp Lys Val Asn Pro Glu Ile Asp Thr Thr Ile Gly Glu Trp 
                245                 250                 255     


Ala Phe Trp Glu Thr Lys Lys Asn Leu Thr Arg Lys Ile Arg Ser Glu 
            260                 265                 270         


Glu Leu Ser Phe Thr Val Val Ser Asn Gly Ala Lys Asn Ile Ser Gly 
        275                 280                 285             


Lys Leu Gly Leu Ile Thr Asn Thr Ile Ala Gly Val Ala Gly Leu Ile 
    290                 295                 300                 


Thr Gly Gly Arg Arg Thr Arg Arg Glu Ala Ile Val Asn Ala Gln Pro 
305                 310                 315                 320 


Lys Cys Asn Pro Asn Leu His Tyr Trp Thr Thr Gln Asp Glu Gly Ala 
                325                 330                 335     


Ala Ile Gly Leu Ala Trp Ile Pro Tyr Phe Gly Pro Ala Ala Glu Gly 
            340                 345                 350         


Ile Tyr Ile Glu Gly Leu Met His Asn Gln Asp Gly Leu Ile Cys Gly 
        355                 360                 365             


Leu Arg Gln Leu Ala Asn Glu Thr Thr Gln Ala Leu Gln Leu Phe Leu 
    370                 375                 380                 


Arg Ala Thr Pro Glu Leu Arg Thr Phe Ser Ile Leu Asn Arg Lys Ala 
385                 390                 395                 400 


Ile Asp Phe Leu Leu Gln Arg Trp Gly Gly Thr Cys His Ile Leu Gly 
                405                 410                 415     


Pro Asp Cys Cys Ile Glu Pro His Asp Trp Thr Lys Asn Ile Thr Asp 
            420                 425                 430         


Lys Ile Asp Gln Ile Ile His Asp Phe Val Asp Lys Thr Leu Pro Asp 
        435                 440                 445             


Gln Gly Asp Asn Asp Asn Trp Trp Thr Gly 
    450                 455             


<210> 8
<211> 458
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 8
Ile Pro Leu Gly Val Ile His Asn Ser Thr Leu Gln Val Ser Asp Val 
1               5                   10                  15      


Asp Lys Leu Val Cys Arg Asp Lys Leu Ser Ser Thr Asn Gln Leu Arg 
            20                  25                  30          


Ser Val Gly Leu Asn Leu Glu Gly Asn Gly Val Ala Thr Asp Val Pro 
        35                  40                  45              


Ser Ala Thr Lys Arg Trp Gly Phe Arg Ser Gly Val Pro Pro Lys Val 
    50                  55                  60                  


Val Asn Tyr Glu Ala Gly Glu Trp Ala Glu Asn Cys Tyr Asn Leu Glu 
65                  70                  75                  80  


Ile Lys Lys Pro Asp Gly Ser Glu Cys Leu Pro Ala Ala Pro Asp Gly 
                85                  90                  95      


Ile Arg Gly Phe Pro Arg Cys Arg Tyr Val His Lys Val Ser Gly Thr 
            100                 105                 110         


Gly Pro Cys Ala Gly Asp Phe Ala Phe His Lys Glu Gly Ala Phe Phe 
        115                 120                 125             


Leu Tyr Asp Arg Leu Ala Ser Thr Val Ile Tyr Arg Gly Thr Thr Phe 
    130                 135                 140                 


Ala Glu Gly Val Val Ala Phe Leu Ile Leu Pro Gln Ala Lys Lys Asp 
145                 150                 155                 160 


Phe Phe Ser Ser His Pro Leu Arg Glu Pro Val Asn Ala Thr Glu Asp 
                165                 170                 175     


Pro Ser Ser Gly Tyr Tyr Ser Thr Thr Ile Arg Tyr Gln Ala Thr Gly 
            180                 185                 190         


Phe Gly Thr Asn Glu Thr Glu Tyr Leu Phe Glu Val Asp Asn Leu Thr 
        195                 200                 205             


Tyr Val Gln Leu Glu Ser Arg Phe Thr Pro Gln Phe Leu Leu Gln Leu 
    210                 215                 220                 


Asn Glu Thr Ile Tyr Thr Ser Gly Lys Arg Ser Asn Thr Thr Gly Lys 
225                 230                 235                 240 


Leu Ile Trp Lys Val Asn Pro Glu Ile Asp Thr Thr Ile Gly Glu Trp 
                245                 250                 255     


Ala Phe Trp Glu Thr Lys Lys Asn Leu Thr Arg Lys Ile Arg Ser Glu 
            260                 265                 270         


Glu Leu Ser Phe Thr Val Val Ser Asn Gly Ala Lys Asn Ile Ser Gly 
        275                 280                 285             


Lys Leu Gly Leu Ile Thr Asn Thr Ile Ala Gly Val Ala Gly Leu Ile 
    290                 295                 300                 


Thr Gly Gly Arg Arg Thr Arg Arg Glu Ala Ile Val Asn Ala Gln Pro 
305                 310                 315                 320 


Lys Cys Asn Pro Asn Leu His Tyr Trp Thr Thr Gln Asp Glu Gly Ala 
                325                 330                 335     


Ala Ile Gly Leu Ala Trp Ile Pro Tyr Phe Gly Pro Ala Ala Glu Gly 
            340                 345                 350         


Ile Tyr Ile Glu Gly Leu Met His Asn Gln Asp Gly Leu Ile Cys Gly 
        355                 360                 365             


Leu Arg Gln Leu Ala Asn Glu Thr Thr Gln Ala Leu Gln Leu Phe Leu 
    370                 375                 380                 


Arg Ala Thr Thr Glu Leu Arg Thr Phe Ser Ile Leu Asn Arg Phe Ala 
385                 390                 395                 400 


Ile Asp Phe Leu Leu Gln Arg Trp Gly Gly Thr Cys His Ile Leu Gly 
                405                 410                 415     


Pro Asp Cys Cys Ile Glu Pro His Asp Trp Thr Lys Asn Ile Thr Asp 
            420                 425                 430         


Lys Ile Asp Gln Ile Ile His Asp Phe Val Asp Lys Thr Leu Pro Asp 
        435                 440                 445             


Gln Gly Asp Asn Asp Asn Trp Trp Thr Gly 
    450                 455             


<210> 9
<211> 458
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 9
Ile Pro Leu Gly Val Ile His Asn Ser Thr Leu Gln Val Ser Asp Val 
1               5                   10                  15      


Asp Lys Leu Val Cys Arg Asp Lys Leu Ser Ser Thr Asn Gln Leu Arg 
            20                  25                  30          


Ser Val Gly Leu Asn Leu Glu Gly Asn Gly Val Ala Thr Asp Val Pro 
        35                  40                  45              


Ser Ala Thr Lys Arg Trp Gly Phe Arg Ser Gly Val Pro Pro Lys Val 
    50                  55                  60                  


Val Asn Tyr Glu Ala Gly Glu Trp Ala Glu Asn Cys Tyr Asn Leu Glu 
65                  70                  75                  80  


Ile Lys Lys Pro Asp Gly Ser Glu Cys Leu Pro Ala Ala Pro Asp Gly 
                85                  90                  95      


Ile Arg Gly Phe Pro Arg Cys Arg Tyr Val His Lys Val Ser Gly Thr 
            100                 105                 110         


Gly Pro Cys Ala Gly Asp Phe Ala Phe His Lys Glu Gly Ala Phe Phe 
        115                 120                 125             


Leu Tyr Asp Arg Leu Ala Ser Thr Val Ile Tyr Arg Gly Thr Thr Phe 
    130                 135                 140                 


Ala Glu Gly Val Val Ala Phe Leu Ile Leu Pro Gln Ala Lys Lys Asp 
145                 150                 155                 160 


Phe Phe Ser Ser His Pro Leu Arg Glu Pro Val Asn Ala Thr Glu Asp 
                165                 170                 175     


Pro Ser Ser Gly Tyr Tyr Ser Thr Thr Ile Arg Tyr Gln Ala Thr Gly 
            180                 185                 190         


Phe Gly Thr Asn Glu Thr Glu Tyr Leu Phe Glu Val Asp Asn Leu Thr 
        195                 200                 205             


Tyr Val Gln Leu Glu Ser Arg Phe Thr Pro Gln Phe Leu Leu Gln Leu 
    210                 215                 220                 


Asn Glu Thr Ile Tyr Thr Ser Gly Lys Arg Ser Asn Thr Thr Gly Lys 
225                 230                 235                 240 


Leu Ile Trp Lys Val Asn Pro Glu Ile Asp Thr Thr Ile Gly Glu Trp 
                245                 250                 255     


Ala Phe Trp Glu Thr Lys Lys Asn Leu Thr Arg Lys Ile Arg Ser Glu 
            260                 265                 270         


Glu Leu Ser Phe Thr Val Val Ser Asn Gly Ala Lys Asn Ile Ser Gly 
        275                 280                 285             


Lys Leu Gly Leu Ile Thr Asn Thr Ile Ala Gly Val Ala Gly Leu Ile 
    290                 295                 300                 


Thr Gly Gly Arg Arg Thr Arg Arg Glu Ala Ile Val Asn Ala Gln Pro 
305                 310                 315                 320 


Lys Cys Asn Pro Asn Leu His Tyr Trp Thr Thr Gln Asp Glu Gly Ala 
                325                 330                 335     


Ala Ile Gly Leu Ala Trp Ile Pro Tyr Phe Gly Pro Ala Ala Glu Gly 
            340                 345                 350         


Ile Tyr Ile Glu Gly Leu Met His Asn Gln Asp Gly Leu Ile Cys Gly 
        355                 360                 365             


Leu Arg Gln Leu Ala Asn Glu Thr Thr Gln Ala Leu Gln Leu Phe Leu 
    370                 375                 380                 


Arg Ala Thr Pro Glu Leu Arg Thr Phe Ser Ile Leu Asn Arg Phe Ala 
385                 390                 395                 400 


Ile Asp Phe Leu Leu Gln Arg Trp Gly Gly Thr Cys His Ile Leu Gly 
                405                 410                 415     


Pro Asp Cys Cys Ile Glu Pro His Asp Trp Thr Lys Asn Ile Thr Asp 
            420                 425                 430         


Lys Ile Asp Gln Ile Ile His Asp Phe Val Asp Lys Thr Leu Pro Asp 
        435                 440                 445             


Gln Gly Asp Asn Asp Asn Trp Trp Thr Gly 
    450                 455             


<210> 10
<211> 615
<212> PRT
<213> Zaire ebolavirus

<400> 10
Ile Pro Leu Gly Val Ile His Asn Ser Thr Leu Gln Val Ser Asp Val 
1               5                   10                  15      


Asp Lys Leu Val Cys Arg Asp Lys Leu Ser Ser Thr Asn Gln Leu Arg 
            20                  25                  30          


Ser Val Gly Leu Asn Leu Glu Gly Asn Gly Val Ala Thr Asp Val Pro 
        35                  40                  45              


Ser Val Thr Lys Arg Trp Gly Phe Arg Ser Gly Val Pro Pro Lys Val 
    50                  55                  60                  


Val Asn Tyr Glu Ala Gly Glu Trp Ala Glu Asn Cys Tyr Asn Leu Glu 
65                  70                  75                  80  


Ile Lys Lys Pro Asp Gly Ser Glu Cys Leu Pro Ala Ala Pro Asp Gly 
                85                  90                  95      


Ile Arg Gly Phe Pro Arg Cys Arg Tyr Val His Lys Val Ser Gly Thr 
            100                 105                 110         


Gly Pro Cys Ala Gly Asp Phe Ala Phe His Lys Glu Gly Ala Phe Phe 
        115                 120                 125             


Leu Tyr Asp Arg Leu Ala Ser Thr Val Ile Tyr Arg Gly Thr Thr Phe 
    130                 135                 140                 


Ala Glu Gly Val Val Ala Phe Leu Ile Leu Pro Gln Ala Lys Lys Asp 
145                 150                 155                 160 


Phe Phe Ser Ser His Pro Leu Arg Glu Pro Val Asn Ala Thr Glu Asp 
                165                 170                 175     


Pro Ser Ser Gly Tyr Tyr Ser Thr Thr Ile Arg Tyr Gln Ala Thr Gly 
            180                 185                 190         


Phe Gly Thr Asn Glu Thr Glu Tyr Leu Phe Glu Val Asp Asn Leu Thr 
        195                 200                 205             


Tyr Val Gln Leu Glu Ser Arg Phe Thr Pro Gln Phe Leu Leu Gln Leu 
    210                 215                 220                 


Asn Glu Thr Ile Tyr Ala Ser Gly Lys Arg Ser Asn Thr Thr Gly Lys 
225                 230                 235                 240 


Leu Ile Trp Lys Val Asn Pro Glu Ile Asp Thr Thr Ile Gly Glu Trp 
                245                 250                 255     


Ala Phe Trp Glu Thr Lys Lys Asn Leu Thr Arg Lys Ile Arg Ser Glu 
            260                 265                 270         


Glu Leu Ser Phe Thr Ala Val Ser Asn Gly Pro Lys Asn Ile Ser Gly 
        275                 280                 285             


Gln Ser Pro Ala Arg Thr Ser Ser Asp Pro Glu Thr Asn Thr Thr Asn 
    290                 295                 300                 


Glu Asp His Lys Ile Met Ala Ser Glu Asn Ser Ser Ala Met Val Gln 
305                 310                 315                 320 


Val His Ser Gln Gly Arg Lys Ala Ala Val Ser His Leu Thr Thr Leu 
                325                 330                 335     


Ala Thr Ile Ser Thr Ser Pro Gln Pro Pro Thr Thr Lys Thr Gly Pro 
            340                 345                 350         


Asp Asn Ser Thr His Asn Thr Pro Val Tyr Lys Leu Asp Ile Ser Glu 
        355                 360                 365             


Ala Thr Gln Val Gly Gln His His Arg Arg Ala Asp Asn Asp Ser Thr 
    370                 375                 380                 


Ala Ser Asp Thr Pro Pro Ala Thr Thr Ala Ala Gly Pro Leu Lys Ala 
385                 390                 395                 400 


Glu Asn Thr Asn Thr Ser Lys Ser Ala Asp Ser Leu Asp Leu Ala Thr 
                405                 410                 415     


Thr Thr Ser Pro Gln Asn Tyr Ser Glu Thr Ala Gly Asn Asn Asn Thr 
            420                 425                 430         


His His Gln Asp Thr Gly Glu Glu Ser Ala Ser Ser Gly Lys Leu Gly 
        435                 440                 445             


Leu Ile Thr Asn Thr Ile Ala Gly Val Ala Gly Leu Ile Thr Gly Gly 
    450                 455                 460                 


Arg Arg Thr Arg Arg Glu Val Ile Val Asn Ala Gln Pro Lys Cys Asn 
465                 470                 475                 480 


Pro Asn Leu His Tyr Trp Thr Thr Gln Asp Glu Gly Ala Ala Ile Gly 
                485                 490                 495     


Leu Ala Trp Ile Pro Tyr Phe Gly Pro Ala Ala Glu Gly Ile Tyr Thr 
            500                 505                 510         


Glu Gly Leu Met His Asn Gln Asp Gly Leu Ile Cys Gly Leu Arg Gln 
        515                 520                 525             


Leu Ala Asn Glu Thr Thr Gln Ala Leu Gln Leu Phe Leu Arg Ala Thr 
    530                 535                 540                 


Thr Glu Leu Arg Thr Phe Ser Ile Leu Asn Arg Lys Ala Ile Asp Phe 
545                 550                 555                 560 


Leu Leu Gln Arg Trp Gly Gly Thr Cys His Ile Leu Gly Pro Asp Cys 
                565                 570                 575     


Cys Ile Glu Pro His Asp Trp Thr Lys Asn Ile Thr Asp Lys Ile Asp 
            580                 585                 590         


Gln Ile Ile His Asp Phe Val Asp Lys Thr Leu Pro Asp Gln Gly Asp 
        595                 600                 605             


Asn Asp Asn Trp Trp Thr Gly 
    610                 615 


<210> 11
<211> 615
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 11
Ile Pro Leu Gly Val Ile His Asn Ser Thr Leu Gln Val Ser Asp Val 
1               5                   10                  15      


Asp Lys Leu Val Cys Arg Asp Lys Leu Ser Ser Thr Asn Gln Leu Arg 
            20                  25                  30          


Ser Val Gly Leu Asn Leu Glu Gly Asn Gly Val Ala Thr Asp Val Pro 
        35                  40                  45              


Ser Val Thr Lys Arg Trp Gly Phe Arg Ser Gly Val Pro Pro Lys Val 
    50                  55                  60                  


Val Asn Tyr Glu Ala Gly Glu Trp Ala Glu Asn Cys Tyr Asn Leu Glu 
65                  70                  75                  80  


Ile Lys Lys Pro Asp Gly Ser Glu Cys Leu Pro Ala Ala Pro Asp Gly 
                85                  90                  95      


Ile Arg Gly Phe Pro Arg Cys Arg Tyr Val His Lys Val Ser Gly Thr 
            100                 105                 110         


Gly Pro Cys Ala Gly Asp Phe Ala Phe His Lys Glu Gly Ala Phe Phe 
        115                 120                 125             


Leu Tyr Asp Arg Leu Ala Ser Thr Val Ile Tyr Arg Gly Thr Thr Phe 
    130                 135                 140                 


Ala Glu Gly Val Val Ala Phe Leu Ile Leu Pro Gln Ala Lys Lys Asp 
145                 150                 155                 160 


Phe Phe Ser Ser His Pro Leu Arg Glu Pro Val Asn Ala Thr Glu Asp 
                165                 170                 175     


Pro Ser Ser Gly Tyr Tyr Ser Thr Thr Ile Arg Tyr Gln Ala Thr Gly 
            180                 185                 190         


Phe Gly Thr Asn Glu Thr Glu Tyr Leu Phe Glu Val Asp Asn Leu Thr 
        195                 200                 205             


Tyr Val Gln Leu Glu Ser Arg Phe Thr Pro Gln Phe Leu Leu Gln Leu 
    210                 215                 220                 


Asn Glu Thr Ile Tyr Ala Ser Gly Lys Arg Ser Asn Thr Thr Gly Lys 
225                 230                 235                 240 


Leu Ile Trp Lys Val Asn Pro Glu Ile Asp Thr Thr Ile Gly Glu Trp 
                245                 250                 255     


Ala Phe Trp Glu Thr Lys Lys Asn Leu Thr Arg Lys Ile Arg Ser Glu 
            260                 265                 270         


Glu Leu Ser Phe Thr Ala Val Ser Asn Gly Pro Lys Asn Ile Ser Gly 
        275                 280                 285             


Gln Ser Pro Ala Arg Thr Ser Ser Asp Pro Glu Thr Asn Thr Thr Asn 
    290                 295                 300                 


Glu Asp His Lys Ile Met Ala Ser Glu Asn Ser Ser Ala Met Val Gln 
305                 310                 315                 320 


Val His Ser Gln Gly Arg Lys Ala Ala Val Ser His Leu Thr Thr Leu 
                325                 330                 335     


Ala Thr Ile Ser Thr Ser Pro Gln Pro Pro Thr Thr Lys Thr Gly Pro 
            340                 345                 350         


Asp Asn Ser Thr His Asn Thr Pro Val Tyr Lys Leu Asp Ile Ser Glu 
        355                 360                 365             


Ala Thr Gln Val Gly Gln His His Arg Arg Ala Asp Asn Asp Ser Thr 
    370                 375                 380                 


Ala Ser Asp Thr Pro Pro Ala Thr Thr Ala Ala Gly Pro Leu Lys Ala 
385                 390                 395                 400 


Glu Asn Thr Asn Thr Ser Lys Ser Ala Asp Ser Leu Asp Leu Ala Thr 
                405                 410                 415     


Thr Thr Ser Pro Gln Asn Tyr Ser Glu Thr Ala Gly Asn Asn Asn Thr 
            420                 425                 430         


His His Gln Asp Thr Gly Glu Glu Ser Ala Ser Ser Gly Lys Leu Gly 
        435                 440                 445             


Leu Ile Thr Asn Thr Ile Ala Gly Val Ala Gly Leu Ile Thr Gly Gly 
    450                 455                 460                 


Arg Arg Thr Arg Arg Glu Val Ile Val Asn Ala Gln Pro Lys Cys Asn 
465                 470                 475                 480 


Pro Asn Leu His Tyr Trp Thr Thr Gln Asp Glu Gly Ala Ala Ile Gly 
                485                 490                 495     


Leu Ala Trp Ile Pro Tyr Phe Gly Pro Ala Ala Glu Gly Ile Tyr Thr 
            500                 505                 510         


Glu Gly Leu Met His Asn Gln Asp Gly Leu Ile Cys Gly Leu Arg Gln 
        515                 520                 525             


Leu Ala Asn Glu Thr Thr Gln Ala Leu Gln Leu Phe Leu Arg Ala Thr 
    530                 535                 540                 


Pro Glu Leu Arg Thr Phe Ser Ile Leu Asn Arg Lys Ala Ile Asp Phe 
545                 550                 555                 560 


Leu Leu Gln Arg Trp Gly Gly Thr Cys His Ile Leu Gly Pro Asp Cys 
                565                 570                 575     


Cys Ile Glu Pro His Asp Trp Thr Lys Asn Ile Thr Asp Lys Ile Asp 
            580                 585                 590         


Gln Ile Ile His Asp Phe Val Asp Lys Thr Leu Pro Asp Gln Gly Asp 
        595                 600                 605             


Asn Asp Asn Trp Trp Thr Gly 
    610                 615 


<210> 12
<211> 615
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 12
Ile Pro Leu Gly Val Ile His Asn Ser Thr Leu Gln Val Ser Asp Val 
1               5                   10                  15      


Asp Lys Leu Val Cys Arg Asp Lys Leu Ser Ser Thr Asn Gln Leu Arg 
            20                  25                  30          


Ser Val Gly Leu Asn Leu Glu Gly Asn Gly Val Ala Thr Asp Val Pro 
        35                  40                  45              


Ser Val Thr Lys Arg Trp Gly Phe Arg Ser Gly Val Pro Pro Lys Val 
    50                  55                  60                  


Val Asn Tyr Glu Ala Gly Glu Trp Ala Glu Asn Cys Tyr Asn Leu Glu 
65                  70                  75                  80  


Ile Lys Lys Pro Asp Gly Ser Glu Cys Leu Pro Ala Ala Pro Asp Gly 
                85                  90                  95      


Ile Arg Gly Phe Pro Arg Cys Arg Tyr Val His Lys Val Ser Gly Thr 
            100                 105                 110         


Gly Pro Cys Ala Gly Asp Phe Ala Phe His Lys Glu Gly Ala Phe Phe 
        115                 120                 125             


Leu Tyr Asp Arg Leu Ala Ser Thr Val Ile Tyr Arg Gly Thr Thr Phe 
    130                 135                 140                 


Ala Glu Gly Val Val Ala Phe Leu Ile Leu Pro Gln Ala Lys Lys Asp 
145                 150                 155                 160 


Phe Phe Ser Ser His Pro Leu Arg Glu Pro Val Asn Ala Thr Glu Asp 
                165                 170                 175     


Pro Ser Ser Gly Tyr Tyr Ser Thr Thr Ile Arg Tyr Gln Ala Thr Gly 
            180                 185                 190         


Phe Gly Thr Asn Glu Thr Glu Tyr Leu Phe Glu Val Asp Asn Leu Thr 
        195                 200                 205             


Tyr Val Gln Leu Glu Ser Arg Phe Thr Pro Gln Phe Leu Leu Gln Leu 
    210                 215                 220                 


Asn Glu Thr Ile Tyr Ala Ser Gly Lys Arg Ser Asn Thr Thr Gly Lys 
225                 230                 235                 240 


Leu Ile Trp Lys Val Asn Pro Glu Ile Asp Thr Thr Ile Gly Glu Trp 
                245                 250                 255     


Ala Phe Trp Glu Thr Lys Lys Asn Leu Thr Arg Lys Ile Arg Ser Glu 
            260                 265                 270         


Glu Leu Ser Phe Thr Ala Val Ser Asn Gly Pro Lys Asn Ile Ser Gly 
        275                 280                 285             


Gln Ser Pro Ala Arg Thr Ser Ser Asp Pro Glu Thr Asn Thr Thr Asn 
    290                 295                 300                 


Glu Asp His Lys Ile Met Ala Ser Glu Asn Ser Ser Ala Met Val Gln 
305                 310                 315                 320 


Val His Ser Gln Gly Arg Lys Ala Ala Val Ser His Leu Thr Thr Leu 
                325                 330                 335     


Ala Thr Ile Ser Thr Ser Pro Gln Pro Pro Thr Thr Lys Thr Gly Pro 
            340                 345                 350         


Asp Asn Ser Thr His Asn Thr Pro Val Tyr Lys Leu Asp Ile Ser Glu 
        355                 360                 365             


Ala Thr Gln Val Gly Gln His His Arg Arg Ala Asp Asn Asp Ser Thr 
    370                 375                 380                 


Ala Ser Asp Thr Pro Pro Ala Thr Thr Ala Ala Gly Pro Leu Lys Ala 
385                 390                 395                 400 


Glu Asn Thr Asn Thr Ser Lys Ser Ala Asp Ser Leu Asp Leu Ala Thr 
                405                 410                 415     


Thr Thr Ser Pro Gln Asn Tyr Ser Glu Thr Ala Gly Asn Asn Asn Thr 
            420                 425                 430         


His His Gln Asp Thr Gly Glu Glu Ser Ala Ser Ser Gly Lys Leu Gly 
        435                 440                 445             


Leu Ile Thr Asn Thr Ile Ala Gly Val Ala Gly Leu Ile Thr Gly Gly 
    450                 455                 460                 


Arg Arg Thr Arg Arg Glu Val Ile Val Asn Ala Gln Pro Lys Cys Asn 
465                 470                 475                 480 


Pro Asn Leu His Tyr Trp Thr Thr Gln Asp Glu Gly Ala Ala Ile Gly 
                485                 490                 495     


Leu Ala Trp Ile Pro Tyr Phe Gly Pro Ala Ala Glu Gly Ile Tyr Thr 
            500                 505                 510         


Glu Gly Leu Met His Asn Gln Asp Gly Leu Ile Cys Gly Leu Arg Gln 
        515                 520                 525             


Leu Ala Asn Glu Thr Thr Gln Ala Leu Gln Leu Phe Leu Arg Ala Thr 
    530                 535                 540                 


Thr Glu Leu Arg Thr Phe Ser Ile Leu Asn Arg Phe Ala Ile Asp Phe 
545                 550                 555                 560 


Leu Leu Gln Arg Trp Gly Gly Thr Cys His Ile Leu Gly Pro Asp Cys 
                565                 570                 575     


Cys Ile Glu Pro His Asp Trp Thr Lys Asn Ile Thr Asp Lys Ile Asp 
            580                 585                 590         


Gln Ile Ile His Asp Phe Val Asp Lys Thr Leu Pro Asp Gln Gly Asp 
        595                 600                 605             


Asn Asp Asn Trp Trp Thr Gly 
    610                 615 


<210> 13
<211> 615
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 13
Ile Pro Leu Gly Val Ile His Asn Ser Thr Leu Gln Val Ser Asp Val 
1               5                   10                  15      


Asp Lys Leu Val Cys Arg Asp Lys Leu Ser Ser Thr Asn Gln Leu Arg 
            20                  25                  30          


Ser Val Gly Leu Asn Leu Glu Gly Asn Gly Val Ala Thr Asp Val Pro 
        35                  40                  45              


Ser Val Thr Lys Arg Trp Gly Phe Arg Ser Gly Val Pro Pro Lys Val 
    50                  55                  60                  


Val Asn Tyr Glu Ala Gly Glu Trp Ala Glu Asn Cys Tyr Asn Leu Glu 
65                  70                  75                  80  


Ile Lys Lys Pro Asp Gly Ser Glu Cys Leu Pro Ala Ala Pro Asp Gly 
                85                  90                  95      


Ile Arg Gly Phe Pro Arg Cys Arg Tyr Val His Lys Val Ser Gly Thr 
            100                 105                 110         


Gly Pro Cys Ala Gly Asp Phe Ala Phe His Lys Glu Gly Ala Phe Phe 
        115                 120                 125             


Leu Tyr Asp Arg Leu Ala Ser Thr Val Ile Tyr Arg Gly Thr Thr Phe 
    130                 135                 140                 


Ala Glu Gly Val Val Ala Phe Leu Ile Leu Pro Gln Ala Lys Lys Asp 
145                 150                 155                 160 


Phe Phe Ser Ser His Pro Leu Arg Glu Pro Val Asn Ala Thr Glu Asp 
                165                 170                 175     


Pro Ser Ser Gly Tyr Tyr Ser Thr Thr Ile Arg Tyr Gln Ala Thr Gly 
            180                 185                 190         


Phe Gly Thr Asn Glu Thr Glu Tyr Leu Phe Glu Val Asp Asn Leu Thr 
        195                 200                 205             


Tyr Val Gln Leu Glu Ser Arg Phe Thr Pro Gln Phe Leu Leu Gln Leu 
    210                 215                 220                 


Asn Glu Thr Ile Tyr Ala Ser Gly Lys Arg Ser Asn Thr Thr Gly Lys 
225                 230                 235                 240 


Leu Ile Trp Lys Val Asn Pro Glu Ile Asp Thr Thr Ile Gly Glu Trp 
                245                 250                 255     


Ala Phe Trp Glu Thr Lys Lys Asn Leu Thr Arg Lys Ile Arg Ser Glu 
            260                 265                 270         


Glu Leu Ser Phe Thr Ala Val Ser Asn Gly Pro Lys Asn Ile Ser Gly 
        275                 280                 285             


Gln Ser Pro Ala Arg Thr Ser Ser Asp Pro Glu Thr Asn Thr Thr Asn 
    290                 295                 300                 


Glu Asp His Lys Ile Met Ala Ser Glu Asn Ser Ser Ala Met Val Gln 
305                 310                 315                 320 


Val His Ser Gln Gly Arg Lys Ala Ala Val Ser His Leu Thr Thr Leu 
                325                 330                 335     


Ala Thr Ile Ser Thr Ser Pro Gln Pro Pro Thr Thr Lys Thr Gly Pro 
            340                 345                 350         


Asp Asn Ser Thr His Asn Thr Pro Val Tyr Lys Leu Asp Ile Ser Glu 
        355                 360                 365             


Ala Thr Gln Val Gly Gln His His Arg Arg Ala Asp Asn Asp Ser Thr 
    370                 375                 380                 


Ala Ser Asp Thr Pro Pro Ala Thr Thr Ala Ala Gly Pro Leu Lys Ala 
385                 390                 395                 400 


Glu Asn Thr Asn Thr Ser Lys Ser Ala Asp Ser Leu Asp Leu Ala Thr 
                405                 410                 415     


Thr Thr Ser Pro Gln Asn Tyr Ser Glu Thr Ala Gly Asn Asn Asn Thr 
            420                 425                 430         


His His Gln Asp Thr Gly Glu Glu Ser Ala Ser Ser Gly Lys Leu Gly 
        435                 440                 445             


Leu Ile Thr Asn Thr Ile Ala Gly Val Ala Gly Leu Ile Thr Gly Gly 
    450                 455                 460                 


Arg Arg Thr Arg Arg Glu Val Ile Val Asn Ala Gln Pro Lys Cys Asn 
465                 470                 475                 480 


Pro Asn Leu His Tyr Trp Thr Thr Gln Asp Glu Gly Ala Ala Ile Gly 
                485                 490                 495     


Leu Ala Trp Ile Pro Tyr Phe Gly Pro Ala Ala Glu Gly Ile Tyr Thr 
            500                 505                 510         


Glu Gly Leu Met His Asn Gln Asp Gly Leu Ile Cys Gly Leu Arg Gln 
        515                 520                 525             


Leu Ala Asn Glu Thr Thr Gln Ala Leu Gln Leu Phe Leu Arg Ala Thr 
    530                 535                 540                 


Pro Glu Leu Arg Thr Phe Ser Ile Leu Asn Arg Phe Ala Ile Asp Phe 
545                 550                 555                 560 


Leu Leu Gln Arg Trp Gly Gly Thr Cys His Ile Leu Gly Pro Asp Cys 
                565                 570                 575     


Cys Ile Glu Pro His Asp Trp Thr Lys Asn Ile Thr Asp Lys Ile Asp 
            580                 585                 590         


Gln Ile Ile His Asp Phe Val Asp Lys Thr Leu Pro Asp Gln Gly Asp 
        595                 600                 605             


Asn Asp Asn Trp Trp Thr Gly 
    610                 615 


<210> 14
<211> 456
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 14
Ile Pro Leu Gly Val Ile His Asn Ser Thr Leu Gln Val Ser Asp Val 
1               5                   10                  15      


Asp Lys Leu Val Cys Arg Asp Lys Leu Ser Ser Thr Asn Gln Leu Arg 
            20                  25                  30          


Ser Val Gly Leu Asn Leu Glu Gly Asn Gly Val Ala Thr Asp Val Pro 
        35                  40                  45              


Ser Val Thr Lys Arg Trp Gly Phe Arg Ser Gly Val Pro Pro Lys Val 
    50                  55                  60                  


Val Asn Tyr Glu Ala Gly Glu Trp Ala Glu Asn Cys Tyr Asn Leu Glu 
65                  70                  75                  80  


Ile Lys Lys Pro Asp Gly Ser Glu Cys Leu Pro Ala Ala Pro Asp Gly 
                85                  90                  95      


Ile Arg Gly Phe Pro Arg Cys Arg Tyr Val His Lys Val Ser Gly Thr 
            100                 105                 110         


Gly Pro Cys Ala Gly Asp Phe Ala Phe His Lys Glu Gly Ala Phe Phe 
        115                 120                 125             


Leu Tyr Asp Arg Leu Ala Ser Thr Val Ile Tyr Arg Gly Thr Thr Phe 
    130                 135                 140                 


Ala Glu Gly Val Val Ala Phe Leu Ile Leu Pro Gln Ala Lys Lys Asp 
145                 150                 155                 160 


Phe Phe Ser Ser His Pro Leu Arg Glu Pro Val Asn Ala Thr Glu Asp 
                165                 170                 175     


Pro Ser Ser Gly Tyr Tyr Ser Thr Thr Ile Arg Tyr Gln Ala Thr Gly 
            180                 185                 190         


Phe Gly Thr Asn Glu Thr Glu Tyr Leu Phe Glu Val Asp Asn Leu Thr 
        195                 200                 205             


Tyr Val Gln Leu Glu Ser Arg Phe Thr Pro Gln Phe Leu Leu Gln Leu 
    210                 215                 220                 


Asn Glu Thr Ile Tyr Ala Ser Gly Lys Arg Ser Asn Thr Thr Gly Lys 
225                 230                 235                 240 


Leu Ile Trp Lys Val Asn Pro Glu Ile Asp Thr Thr Ile Gly Glu Trp 
                245                 250                 255     


Ala Phe Trp Glu Thr Lys Lys Asn Leu Thr Arg Lys Ile Arg Ser Glu 
            260                 265                 270         


Glu Leu Ser Phe Thr Ala Val Ser Asn Ser Ala Ser Ser Gly Lys Leu 
        275                 280                 285             


Gly Leu Ile Thr Asn Thr Ile Ala Gly Val Ala Gly Leu Ile Thr Gly 
    290                 295                 300                 


Gly Arg Arg Thr Arg Arg Glu Val Ile Val Asn Ala Gln Pro Lys Cys 
305                 310                 315                 320 


Asn Pro Asn Leu His Tyr Trp Thr Thr Gln Asp Glu Gly Ala Ala Ile 
                325                 330                 335     


Gly Leu Ala Trp Ile Pro Tyr Phe Gly Pro Ala Ala Glu Gly Ile Tyr 
            340                 345                 350         


Thr Glu Gly Leu Met His Asn Gln Asp Gly Leu Ile Cys Gly Leu Arg 
        355                 360                 365             


Gln Leu Ala Asn Glu Thr Thr Gln Ala Leu Gln Leu Phe Leu Arg Ala 
    370                 375                 380                 


Thr Thr Glu Leu Arg Thr Phe Ser Ile Leu Asn Arg Lys Ala Ile Asp 
385                 390                 395                 400 


Phe Leu Leu Gln Arg Trp Gly Gly Thr Cys His Ile Leu Gly Pro Asp 
                405                 410                 415     


Cys Cys Ile Glu Pro His Asp Trp Thr Lys Asn Ile Thr Asp Lys Ile 
            420                 425                 430         


Asp Gln Ile Ile His Asp Phe Val Asp Lys Thr Leu Pro Asp Gln Gly 
        435                 440                 445             


Asp Asn Asp Asn Trp Trp Thr Gly 
    450                 455     


<210> 15
<211> 456
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 15
Ile Pro Leu Gly Val Ile His Asn Ser Thr Leu Gln Val Ser Asp Val 
1               5                   10                  15      


Asp Lys Leu Val Cys Arg Asp Lys Leu Ser Ser Thr Asn Gln Leu Arg 
            20                  25                  30          


Ser Val Gly Leu Asn Leu Glu Gly Asn Gly Val Ala Thr Asp Val Pro 
        35                  40                  45              


Ser Val Thr Lys Arg Trp Gly Phe Arg Ser Gly Val Pro Pro Lys Val 
    50                  55                  60                  


Val Asn Tyr Glu Ala Gly Glu Trp Ala Glu Asn Cys Tyr Asn Leu Glu 
65                  70                  75                  80  


Ile Lys Lys Pro Asp Gly Ser Glu Cys Leu Pro Ala Ala Pro Asp Gly 
                85                  90                  95      


Ile Arg Gly Phe Pro Arg Cys Arg Tyr Val His Lys Val Ser Gly Thr 
            100                 105                 110         


Gly Pro Cys Ala Gly Asp Phe Ala Phe His Lys Glu Gly Ala Phe Phe 
        115                 120                 125             


Leu Tyr Asp Arg Leu Ala Ser Thr Val Ile Tyr Arg Gly Thr Thr Phe 
    130                 135                 140                 


Ala Glu Gly Val Val Ala Phe Leu Ile Leu Pro Gln Ala Lys Lys Asp 
145                 150                 155                 160 


Phe Phe Ser Ser His Pro Leu Arg Glu Pro Val Asn Ala Thr Glu Asp 
                165                 170                 175     


Pro Ser Ser Gly Tyr Tyr Ser Thr Thr Ile Arg Tyr Gln Ala Thr Gly 
            180                 185                 190         


Phe Gly Thr Asn Glu Thr Glu Tyr Leu Phe Glu Val Asp Asn Leu Thr 
        195                 200                 205             


Tyr Val Gln Leu Glu Ser Arg Phe Thr Pro Gln Phe Leu Leu Gln Leu 
    210                 215                 220                 


Asn Glu Thr Ile Tyr Ala Ser Gly Lys Arg Ser Asn Thr Thr Gly Lys 
225                 230                 235                 240 


Leu Ile Trp Lys Val Asn Pro Glu Ile Asp Thr Thr Ile Gly Glu Trp 
                245                 250                 255     


Ala Phe Trp Glu Thr Lys Lys Asn Leu Thr Arg Lys Ile Arg Ser Glu 
            260                 265                 270         


Glu Leu Ser Phe Thr Ala Val Ser Asn Ser Ala Ser Ser Gly Lys Leu 
        275                 280                 285             


Gly Leu Ile Thr Asn Thr Ile Ala Gly Val Ala Gly Leu Ile Thr Gly 
    290                 295                 300                 


Gly Arg Arg Thr Arg Arg Glu Val Ile Val Asn Ala Gln Pro Lys Cys 
305                 310                 315                 320 


Asn Pro Asn Leu His Tyr Trp Thr Thr Gln Asp Glu Gly Ala Ala Ile 
                325                 330                 335     


Gly Leu Ala Trp Ile Pro Tyr Phe Gly Pro Ala Ala Glu Gly Ile Tyr 
            340                 345                 350         


Thr Glu Gly Leu Met His Asn Gln Asp Gly Leu Ile Cys Gly Leu Arg 
        355                 360                 365             


Gln Leu Ala Asn Glu Thr Thr Gln Ala Leu Gln Leu Phe Leu Arg Ala 
    370                 375                 380                 


Thr Pro Glu Leu Arg Thr Phe Ser Ile Leu Asn Arg Lys Ala Ile Asp 
385                 390                 395                 400 


Phe Leu Leu Gln Arg Trp Gly Gly Thr Cys His Ile Leu Gly Pro Asp 
                405                 410                 415     


Cys Cys Ile Glu Pro His Asp Trp Thr Lys Asn Ile Thr Asp Lys Ile 
            420                 425                 430         


Asp Gln Ile Ile His Asp Phe Val Asp Lys Thr Leu Pro Asp Gln Gly 
        435                 440                 445             


Asp Asn Asp Asn Trp Trp Thr Gly 
    450                 455     


<210> 16
<211> 456
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 16
Ile Pro Leu Gly Val Ile His Asn Ser Ala Leu Gln Val Ser Asp Val 
1               5                   10                  15      


Asp Lys Leu Val Cys Arg Asp Lys Leu Ser Ser Thr Asn Gln Leu Arg 
            20                  25                  30          


Ser Val Gly Leu Asn Leu Glu Gly Asn Gly Val Ala Thr Asp Val Pro 
        35                  40                  45              


Ser Val Thr Lys Arg Trp Gly Phe Arg Ser Gly Val Pro Pro Lys Val 
    50                  55                  60                  


Val Asn Tyr Glu Ala Gly Glu Trp Ala Glu Asn Cys Tyr Asn Leu Glu 
65                  70                  75                  80  


Ile Lys Lys Pro Asp Gly Ser Glu Cys Leu Pro Ala Ala Pro Asp Gly 
                85                  90                  95      


Ile Arg Gly Phe Pro Arg Cys Arg Tyr Val His Lys Val Ser Gly Thr 
            100                 105                 110         


Gly Pro Cys Ala Gly Asp Phe Ala Phe His Lys Glu Gly Ala Phe Phe 
        115                 120                 125             


Leu Tyr Asp Arg Leu Ala Ser Thr Val Ile Tyr Arg Gly Thr Thr Phe 
    130                 135                 140                 


Ala Glu Gly Val Val Ala Phe Leu Ile Leu Pro Gln Ala Lys Lys Asp 
145                 150                 155                 160 


Phe Phe Ser Ser His Pro Leu Arg Glu Pro Val Asn Ala Thr Glu Asp 
                165                 170                 175     


Pro Ser Ser Gly Tyr Tyr Ser Thr Thr Ile Arg Tyr Gln Ala Thr Gly 
            180                 185                 190         


Phe Gly Thr Asn Glu Thr Glu Tyr Leu Phe Glu Val Asp Asn Leu Thr 
        195                 200                 205             


Tyr Val Gln Leu Glu Ser Arg Phe Thr Pro Gln Phe Leu Leu Gln Leu 
    210                 215                 220                 


Asn Glu Thr Ile Tyr Ala Ser Gly Lys Arg Ser Asn Thr Thr Gly Lys 
225                 230                 235                 240 


Leu Ile Trp Lys Val Asn Pro Glu Ile Asp Thr Thr Ile Gly Glu Trp 
                245                 250                 255     


Ala Phe Trp Glu Thr Lys Lys Asn Leu Thr Arg Lys Ile Arg Ser Glu 
            260                 265                 270         


Glu Leu Ser Phe Thr Ala Val Ser Asn Ser Ala Ser Ser Gly Lys Leu 
        275                 280                 285             


Gly Leu Ile Thr Asn Thr Ile Ala Gly Val Ala Gly Leu Ile Thr Gly 
    290                 295                 300                 


Gly Arg Arg Thr Arg Arg Glu Val Ile Val Asn Ala Gln Pro Lys Cys 
305                 310                 315                 320 


Asn Pro Asn Leu His Tyr Trp Thr Thr Gln Asp Glu Gly Ala Ala Ile 
                325                 330                 335     


Gly Leu Ala Trp Ile Pro Tyr Phe Gly Pro Ala Ala Glu Gly Ile Tyr 
            340                 345                 350         


Thr Glu Gly Leu Met His Asn Gln Asp Gly Leu Ile Cys Gly Leu Arg 
        355                 360                 365             


Gln Leu Ala Asn Glu Thr Thr Gln Ala Leu Gln Leu Phe Leu Arg Ala 
    370                 375                 380                 


Thr Pro Glu Leu Arg Thr Phe Ser Ile Leu Asn Arg Lys Ala Ile Asp 
385                 390                 395                 400 


Phe Leu Leu Gln Arg Trp Gly Gly Thr Cys His Ile Leu Gly Pro Asp 
                405                 410                 415     


Cys Cys Ile Glu Pro His Asp Trp Thr Lys Asn Ile Thr Asp Lys Ile 
            420                 425                 430         


Asp Gln Ile Ile His Asp Phe Val Asp Lys Thr Leu Pro Asp Gln Gly 
        435                 440                 445             


Asp Asn Asp Asn Trp Trp Thr Gly 
    450                 455     


<210> 17
<211> 456
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 17
Ile Pro Leu Gly Val Ile His Asn Ser Thr Leu Gln Val Ser Asp Val 
1               5                   10                  15      


Asp Lys Leu Val Cys Arg Asp Lys Leu Ser Ser Thr Asn Gln Leu Arg 
            20                  25                  30          


Ser Val Gly Leu Asn Leu Glu Gly Asn Gly Val Ala Thr Asp Val Pro 
        35                  40                  45              


Ser Val Thr Lys Arg Trp Gly Phe Arg Ser Gly Val Pro Pro Lys Val 
    50                  55                  60                  


Val Asn Tyr Glu Ala Gly Glu Trp Ala Glu Asn Cys Tyr Asn Leu Glu 
65                  70                  75                  80  


Ile Lys Lys Pro Asp Gly Ser Glu Cys Leu Pro Ala Ala Pro Asp Gly 
                85                  90                  95      


Ile Arg Gly Phe Pro Arg Cys Arg Tyr Val His Lys Val Ser Gly Thr 
            100                 105                 110         


Gly Pro Cys Ala Gly Asp Phe Ala Phe His Lys Glu Gly Ala Phe Phe 
        115                 120                 125             


Leu Tyr Asp Arg Leu Ala Ser Thr Val Ile Tyr Arg Gly Thr Thr Phe 
    130                 135                 140                 


Ala Glu Gly Val Val Ala Phe Leu Ile Leu Pro Gln Ala Lys Lys Asp 
145                 150                 155                 160 


Phe Phe Ser Ser His Pro Leu Arg Glu Pro Val Asn Ala Thr Glu Asp 
                165                 170                 175     


Pro Ser Ser Gly Tyr Tyr Ser Thr Thr Ile Arg Tyr Gln Ala Thr Gly 
            180                 185                 190         


Phe Gly Thr Asn Glu Thr Glu Tyr Leu Phe Glu Val Asp Asn Leu Thr 
        195                 200                 205             


Tyr Val Gln Leu Glu Ser Arg Phe Thr Pro Gln Phe Leu Leu Gln Leu 
    210                 215                 220                 


Asn Glu Thr Ile Tyr Ala Ser Gly Lys Arg Ser Asn Thr Thr Gly Lys 
225                 230                 235                 240 


Leu Ile Trp Lys Val Asn Pro Glu Ile Asp Thr Thr Ile Gly Glu Trp 
                245                 250                 255     


Ala Phe Trp Glu Thr Lys Lys Asn Leu Thr Arg Lys Ile Arg Ser Glu 
            260                 265                 270         


Glu Leu Ser Phe Thr Ala Val Ser Asn Ser Ala Ser Ser Gly Lys Leu 
        275                 280                 285             


Gly Leu Ile Thr Asn Thr Ile Ala Gly Val Ala Gly Leu Ile Thr Gly 
    290                 295                 300                 


Gly Arg Arg Thr Arg Arg Glu Val Ile Val Asn Ala Gln Pro Lys Cys 
305                 310                 315                 320 


Asn Pro Asn Leu His Tyr Trp Thr Thr Gln Asp Glu Gly Ala Ala Ile 
                325                 330                 335     


Gly Leu Ala Trp Ile Pro Tyr Phe Gly Pro Ala Ala Glu Gly Ile Tyr 
            340                 345                 350         


Thr Glu Gly Leu Met His Asn Gln Asp Gly Leu Ile Cys Gly Leu Arg 
        355                 360                 365             


Gln Leu Ala Asn Glu Thr Thr Gln Ala Leu Gln Leu Phe Leu Arg Ala 
    370                 375                 380                 


Thr Thr Glu Leu Arg Thr Phe Ser Ile Leu Asn Arg Phe Ala Ile Asp 
385                 390                 395                 400 


Phe Leu Leu Gln Arg Trp Gly Gly Thr Cys His Ile Leu Gly Pro Asp 
                405                 410                 415     


Cys Cys Ile Glu Pro His Asp Trp Thr Lys Asn Ile Thr Asp Lys Ile 
            420                 425                 430         


Asp Gln Ile Ile His Asp Phe Val Asp Lys Thr Leu Pro Asp Gln Gly 
        435                 440                 445             


Asp Asn Asp Asn Trp Trp Thr Gly 
    450                 455     


<210> 18
<211> 456
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 18
Ile Pro Leu Gly Val Ile His Asn Ser Thr Leu Gln Val Ser Asp Val 
1               5                   10                  15      


Asp Lys Leu Val Cys Arg Asp Lys Leu Ser Ser Thr Asn Gln Leu Arg 
            20                  25                  30          


Ser Val Gly Leu Asn Leu Glu Gly Asn Gly Val Ala Thr Asp Val Pro 
        35                  40                  45              


Ser Val Thr Lys Arg Trp Gly Phe Arg Ser Gly Val Pro Pro Lys Val 
    50                  55                  60                  


Val Asn Tyr Glu Ala Gly Glu Trp Ala Glu Asn Cys Tyr Asn Leu Glu 
65                  70                  75                  80  


Ile Lys Lys Pro Asp Gly Ser Glu Cys Leu Pro Ala Ala Pro Asp Gly 
                85                  90                  95      


Ile Arg Gly Phe Pro Arg Cys Arg Tyr Val His Lys Val Ser Gly Thr 
            100                 105                 110         


Gly Pro Cys Ala Gly Asp Phe Ala Phe His Lys Glu Gly Ala Phe Phe 
        115                 120                 125             


Leu Tyr Asp Arg Leu Ala Ser Thr Val Ile Tyr Arg Gly Thr Thr Phe 
    130                 135                 140                 


Ala Glu Gly Val Val Ala Phe Leu Ile Leu Pro Gln Ala Lys Lys Asp 
145                 150                 155                 160 


Phe Phe Ser Ser His Pro Leu Arg Glu Pro Val Asn Ala Thr Glu Asp 
                165                 170                 175     


Pro Ser Ser Gly Tyr Tyr Ser Thr Thr Ile Arg Tyr Gln Ala Thr Gly 
            180                 185                 190         


Phe Gly Thr Asn Glu Thr Glu Tyr Leu Phe Glu Val Asp Asn Leu Thr 
        195                 200                 205             


Tyr Val Gln Leu Glu Ser Arg Phe Thr Pro Gln Phe Leu Leu Gln Leu 
    210                 215                 220                 


Asn Glu Thr Ile Tyr Ala Ser Gly Lys Arg Ser Asn Thr Thr Gly Lys 
225                 230                 235                 240 


Leu Ile Trp Lys Val Asn Pro Glu Ile Asp Thr Thr Ile Gly Glu Trp 
                245                 250                 255     


Ala Phe Trp Glu Thr Lys Lys Asn Leu Thr Arg Lys Ile Arg Ser Glu 
            260                 265                 270         


Glu Leu Ser Phe Thr Ala Val Ser Asn Ser Ala Ser Ser Gly Lys Leu 
        275                 280                 285             


Gly Leu Ile Thr Asn Thr Ile Ala Gly Val Ala Gly Leu Ile Thr Gly 
    290                 295                 300                 


Gly Arg Arg Thr Arg Arg Glu Val Ile Val Asn Ala Gln Pro Lys Cys 
305                 310                 315                 320 


Asn Pro Asn Leu His Tyr Trp Thr Thr Gln Asp Glu Gly Ala Ala Ile 
                325                 330                 335     


Gly Leu Ala Trp Ile Pro Tyr Phe Gly Pro Ala Ala Glu Gly Ile Tyr 
            340                 345                 350         


Thr Glu Gly Leu Met His Asn Gln Asp Gly Leu Ile Cys Gly Leu Arg 
        355                 360                 365             


Gln Leu Ala Asn Glu Thr Thr Gln Ala Leu Gln Leu Phe Leu Arg Ala 
    370                 375                 380                 


Thr Pro Glu Leu Arg Thr Phe Ser Ile Leu Asn Arg Phe Ala Ile Asp 
385                 390                 395                 400 


Phe Leu Leu Gln Arg Trp Gly Gly Thr Cys His Ile Leu Gly Pro Asp 
                405                 410                 415     


Cys Cys Ile Glu Pro His Asp Trp Thr Lys Asn Ile Thr Asp Lys Ile 
            420                 425                 430         


Asp Gln Ile Ile His Asp Phe Val Asp Lys Thr Leu Pro Asp Gln Gly 
        435                 440                 445             


Asp Asn Asp Asn Trp Trp Thr Gly 
    450                 455     


<210> 19
<211> 615
<212> PRT
<213> Zaire ebolavirus

<400> 19
Ile Pro Leu Gly Val Ile His Asn Ser Thr Leu Gln Val Ser Asp Val 
1               5                   10                  15      


Asp Lys Leu Val Cys Arg Asp Lys Leu Ser Ser Thr Asn Gln Leu Arg 
            20                  25                  30          


Ser Val Gly Leu Asn Leu Glu Gly Asn Gly Val Ala Thr Asp Val Pro 
        35                  40                  45              


Ser Ala Thr Lys Arg Trp Gly Phe Arg Ser Gly Val Pro Pro Lys Val 
    50                  55                  60                  


Val Asn Tyr Glu Ala Gly Glu Trp Ala Glu Asn Cys Tyr Asn Leu Glu 
65                  70                  75                  80  


Ile Lys Lys Pro Asp Gly Ser Glu Cys Leu Pro Ala Ala Pro Asp Gly 
                85                  90                  95      


Ile Arg Gly Phe Pro Arg Cys Arg Tyr Val His Lys Val Ser Gly Thr 
            100                 105                 110         


Gly Pro Cys Ala Gly Asp Phe Ala Phe His Lys Glu Gly Ala Phe Phe 
        115                 120                 125             


Leu Tyr Asp Arg Leu Ala Ser Thr Val Ile Tyr Arg Gly Thr Thr Phe 
    130                 135                 140                 


Ala Glu Gly Val Val Ala Phe Leu Ile Leu Pro Gln Ala Lys Lys Asp 
145                 150                 155                 160 


Phe Phe Ser Ser His Pro Leu Arg Glu Pro Val Asn Ala Thr Glu Asp 
                165                 170                 175     


Pro Ser Ser Gly Tyr Tyr Ser Thr Thr Ile Arg Tyr Gln Ala Thr Gly 
            180                 185                 190         


Phe Gly Thr Asn Glu Thr Glu Tyr Leu Phe Glu Val Asp Asn Leu Thr 
        195                 200                 205             


Tyr Val Gln Leu Glu Ser Arg Phe Thr Pro Gln Phe Leu Leu Gln Leu 
    210                 215                 220                 


Asn Glu Thr Ile Tyr Thr Ser Gly Lys Arg Ser Asn Thr Thr Gly Lys 
225                 230                 235                 240 


Leu Ile Trp Lys Val Asn Pro Glu Ile Asp Thr Thr Ile Gly Glu Trp 
                245                 250                 255     


Ala Phe Trp Glu Thr Lys Lys Asn Leu Thr Arg Lys Ile Arg Ser Glu 
            260                 265                 270         


Glu Leu Ser Phe Thr Ala Val Ser Asn Arg Ala Lys Asn Ile Ser Gly 
        275                 280                 285             


Gln Ser Pro Ala Arg Thr Ser Ser Asp Pro Gly Thr Asn Thr Thr Thr 
    290                 295                 300                 


Glu Asp His Lys Ile Met Ala Ser Glu Asn Ser Ser Ala Met Val Gln 
305                 310                 315                 320 


Val His Ser Gln Gly Arg Glu Ala Ala Val Ser His Leu Thr Thr Leu 
                325                 330                 335     


Ala Thr Ile Ser Thr Ser Pro Gln Pro Pro Thr Thr Lys Pro Gly Pro 
            340                 345                 350         


Asp Asn Ser Thr His Asn Thr Pro Val Tyr Lys Leu Asp Ile Ser Glu 
        355                 360                 365             


Ala Thr Gln Val Glu Gln His His Arg Arg Thr Asp Asn Asp Ser Thr 
    370                 375                 380                 


Ala Ser Asp Thr Pro Pro Ala Thr Thr Ala Ala Gly Pro Leu Lys Ala 
385                 390                 395                 400 


Glu Asn Thr Asn Thr Ser Lys Gly Thr Asp Leu Leu Asp Pro Ala Thr 
                405                 410                 415     


Thr Thr Ser Pro Gln Asn His Ser Glu Thr Ala Gly Asn Asn Asn Thr 
            420                 425                 430         


His His Gln Asp Thr Gly Glu Glu Ser Ala Ser Ser Gly Lys Leu Gly 
        435                 440                 445             


Leu Ile Thr Asn Thr Ile Ala Gly Val Ala Gly Leu Ile Thr Gly Gly 
    450                 455                 460                 


Arg Arg Ala Arg Arg Glu Ala Ile Val Asn Ala Gln Pro Lys Cys Asn 
465                 470                 475                 480 


Pro Asn Leu His Tyr Trp Thr Thr Gln Asp Glu Gly Ala Ala Ile Gly 
                485                 490                 495     


Leu Ala Trp Ile Pro Tyr Phe Gly Pro Ala Ala Glu Gly Ile Tyr Ile 
            500                 505                 510         


Glu Gly Leu Met His Asn Gln Asp Gly Leu Ile Cys Gly Leu Arg Gln 
        515                 520                 525             


Leu Ala Asn Glu Thr Thr Gln Ala Leu Gln Leu Phe Leu Arg Ala Thr 
    530                 535                 540                 


Thr Glu Leu Arg Thr Phe Ser Ile Leu Asn Arg Lys Ala Ile Asp Phe 
545                 550                 555                 560 


Leu Leu Gln Arg Trp Gly Gly Thr Cys His Ile Leu Gly Pro Asp Cys 
                565                 570                 575     


Cys Ile Glu Pro His Asp Trp Thr Lys Asn Ile Thr Asp Lys Ile Asp 
            580                 585                 590         


Gln Ile Ile His Asp Phe Val Asp Lys Thr Leu Pro Asp Gln Gly Asp 
        595                 600                 605             


Asn Asp Asn Trp Trp Thr Gly 
    610                 615 


<210> 20
<211> 615
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 20
Ile Pro Leu Gly Val Ile His Asn Ser Thr Leu Gln Val Ser Asp Val 
1               5                   10                  15      


Asp Lys Leu Val Cys Arg Asp Lys Leu Ser Ser Thr Asn Gln Leu Arg 
            20                  25                  30          


Ser Val Gly Leu Asn Leu Glu Gly Asn Gly Val Ala Thr Asp Val Pro 
        35                  40                  45              


Ser Ala Thr Lys Arg Trp Gly Phe Arg Ser Gly Val Pro Pro Lys Val 
    50                  55                  60                  


Val Asn Tyr Glu Ala Gly Glu Trp Ala Glu Asn Cys Tyr Asn Leu Glu 
65                  70                  75                  80  


Ile Lys Lys Pro Asp Gly Ser Glu Cys Leu Pro Ala Ala Pro Asp Gly 
                85                  90                  95      


Ile Arg Gly Phe Pro Arg Cys Arg Tyr Val His Lys Val Ser Gly Thr 
            100                 105                 110         


Gly Pro Cys Ala Gly Asp Phe Ala Phe His Lys Glu Gly Ala Phe Phe 
        115                 120                 125             


Leu Tyr Asp Arg Leu Ala Ser Thr Val Ile Tyr Arg Gly Thr Thr Phe 
    130                 135                 140                 


Ala Glu Gly Val Val Ala Phe Leu Ile Leu Pro Gln Ala Lys Lys Asp 
145                 150                 155                 160 


Phe Phe Ser Ser His Pro Leu Arg Glu Pro Val Asn Ala Thr Glu Asp 
                165                 170                 175     


Pro Ser Ser Gly Tyr Tyr Ser Thr Thr Ile Arg Tyr Gln Ala Thr Gly 
            180                 185                 190         


Phe Gly Thr Asn Glu Thr Glu Tyr Leu Phe Glu Val Asp Asn Leu Thr 
        195                 200                 205             


Tyr Val Gln Leu Glu Ser Arg Phe Thr Pro Gln Phe Leu Leu Gln Leu 
    210                 215                 220                 


Asn Glu Thr Ile Tyr Thr Ser Gly Lys Arg Ser Asn Thr Thr Gly Lys 
225                 230                 235                 240 


Leu Ile Trp Lys Val Asn Pro Glu Ile Asp Thr Thr Ile Gly Glu Trp 
                245                 250                 255     


Ala Phe Trp Glu Thr Lys Lys Asn Leu Thr Arg Lys Ile Arg Ser Glu 
            260                 265                 270         


Glu Leu Ser Phe Thr Ala Val Ser Asn Arg Ala Lys Asn Ile Ser Gly 
        275                 280                 285             


Gln Ser Pro Ala Arg Thr Ser Ser Asp Pro Gly Thr Asn Thr Thr Thr 
    290                 295                 300                 


Glu Asp His Lys Ile Met Ala Ser Glu Asn Ser Ser Ala Met Val Gln 
305                 310                 315                 320 


Val His Ser Gln Gly Arg Glu Ala Ala Val Ser His Leu Thr Thr Leu 
                325                 330                 335     


Ala Thr Ile Ser Thr Ser Pro Gln Pro Pro Thr Thr Lys Pro Gly Pro 
            340                 345                 350         


Asp Asn Ser Thr His Asn Thr Pro Val Tyr Lys Leu Asp Ile Ser Glu 
        355                 360                 365             


Ala Thr Gln Val Glu Gln His His Arg Arg Thr Asp Asn Asp Ser Thr 
    370                 375                 380                 


Ala Ser Asp Thr Pro Pro Ala Thr Thr Ala Ala Gly Pro Leu Lys Ala 
385                 390                 395                 400 


Glu Asn Thr Asn Thr Ser Lys Gly Thr Asp Leu Leu Asp Pro Ala Thr 
                405                 410                 415     


Thr Thr Ser Pro Gln Asn His Ser Glu Thr Ala Gly Asn Asn Asn Thr 
            420                 425                 430         


His His Gln Asp Thr Gly Glu Glu Ser Ala Ser Ser Gly Lys Leu Gly 
        435                 440                 445             


Leu Ile Thr Asn Thr Ile Ala Gly Val Ala Gly Leu Ile Thr Gly Gly 
    450                 455                 460                 


Arg Arg Ala Arg Arg Glu Ala Ile Val Asn Ala Gln Pro Lys Cys Asn 
465                 470                 475                 480 


Pro Asn Leu His Tyr Trp Thr Thr Gln Asp Glu Gly Ala Ala Ile Gly 
                485                 490                 495     


Leu Ala Trp Ile Pro Tyr Phe Gly Pro Ala Ala Glu Gly Ile Tyr Ile 
            500                 505                 510         


Glu Gly Leu Met His Asn Gln Asp Gly Leu Ile Cys Gly Leu Arg Gln 
        515                 520                 525             


Leu Ala Asn Glu Thr Thr Gln Ala Leu Gln Leu Phe Leu Arg Ala Thr 
    530                 535                 540                 


Pro Glu Leu Arg Thr Phe Ser Ile Leu Asn Arg Lys Ala Ile Asp Phe 
545                 550                 555                 560 


Leu Leu Gln Arg Trp Gly Gly Thr Cys His Ile Leu Gly Pro Asp Cys 
                565                 570                 575     


Cys Ile Glu Pro His Asp Trp Thr Lys Asn Ile Thr Asp Lys Ile Asp 
            580                 585                 590         


Gln Ile Ile His Asp Phe Val Asp Lys Thr Leu Pro Asp Gln Gly Asp 
        595                 600                 605             


Asn Asp Asn Trp Trp Thr Gly 
    610                 615 


<210> 21
<211> 615
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 21
Ile Pro Leu Gly Val Ile His Asn Ser Thr Leu Gln Val Ser Asp Val 
1               5                   10                  15      


Asp Lys Leu Val Cys Arg Asp Lys Leu Ser Ser Thr Asn Gln Leu Arg 
            20                  25                  30          


Ser Val Gly Leu Asn Leu Glu Gly Asn Gly Val Ala Thr Asp Val Pro 
        35                  40                  45              


Ser Ala Thr Lys Arg Trp Gly Phe Arg Ser Gly Val Pro Pro Lys Val 
    50                  55                  60                  


Val Asn Tyr Glu Ala Gly Glu Trp Ala Glu Asn Cys Tyr Asn Leu Glu 
65                  70                  75                  80  


Ile Lys Lys Pro Asp Gly Ser Glu Cys Leu Pro Ala Ala Pro Asp Gly 
                85                  90                  95      


Ile Arg Gly Phe Pro Arg Cys Arg Tyr Val His Lys Val Ser Gly Thr 
            100                 105                 110         


Gly Pro Cys Ala Gly Asp Phe Ala Phe His Lys Glu Gly Ala Phe Phe 
        115                 120                 125             


Leu Tyr Asp Arg Leu Ala Ser Thr Val Ile Tyr Arg Gly Thr Thr Phe 
    130                 135                 140                 


Ala Glu Gly Val Val Ala Phe Leu Ile Leu Pro Gln Ala Lys Lys Asp 
145                 150                 155                 160 


Phe Phe Ser Ser His Pro Leu Arg Glu Pro Val Asn Ala Thr Glu Asp 
                165                 170                 175     


Pro Ser Ser Gly Tyr Tyr Ser Thr Thr Ile Arg Tyr Gln Ala Thr Gly 
            180                 185                 190         


Phe Gly Thr Asn Glu Thr Glu Tyr Leu Phe Glu Val Asp Asn Leu Thr 
        195                 200                 205             


Tyr Val Gln Leu Glu Ser Arg Phe Thr Pro Gln Phe Leu Leu Gln Leu 
    210                 215                 220                 


Asn Glu Thr Ile Tyr Thr Ser Gly Lys Arg Ser Asn Thr Thr Gly Lys 
225                 230                 235                 240 


Leu Ile Trp Lys Val Asn Pro Glu Ile Asp Thr Thr Ile Gly Glu Trp 
                245                 250                 255     


Ala Phe Trp Glu Thr Lys Lys Asn Leu Thr Arg Lys Ile Arg Ser Glu 
            260                 265                 270         


Glu Leu Ser Phe Thr Ala Val Ser Asn Arg Ala Lys Asn Ile Ser Gly 
        275                 280                 285             


Gln Ser Pro Ala Arg Thr Ser Ser Asp Pro Gly Thr Asn Thr Thr Thr 
    290                 295                 300                 


Glu Asp His Lys Ile Met Ala Ser Glu Asn Ser Ser Ala Met Val Gln 
305                 310                 315                 320 


Val His Ser Gln Gly Arg Glu Ala Ala Val Ser His Leu Thr Thr Leu 
                325                 330                 335     


Ala Thr Ile Ser Thr Ser Pro Gln Pro Pro Thr Thr Lys Pro Gly Pro 
            340                 345                 350         


Asp Asn Ser Thr His Asn Thr Pro Val Tyr Lys Leu Asp Ile Ser Glu 
        355                 360                 365             


Ala Thr Gln Val Glu Gln His His Arg Arg Thr Asp Asn Asp Ser Thr 
    370                 375                 380                 


Ala Ser Asp Thr Pro Pro Ala Thr Thr Ala Ala Gly Pro Leu Lys Ala 
385                 390                 395                 400 


Glu Asn Thr Asn Thr Ser Lys Gly Thr Asp Leu Leu Asp Pro Ala Thr 
                405                 410                 415     


Thr Thr Ser Pro Gln Asn His Ser Glu Thr Ala Gly Asn Asn Asn Thr 
            420                 425                 430         


His His Gln Asp Thr Gly Glu Glu Ser Ala Ser Ser Gly Lys Leu Gly 
        435                 440                 445             


Leu Ile Thr Asn Thr Ile Ala Gly Val Ala Gly Leu Ile Thr Gly Gly 
    450                 455                 460                 


Arg Arg Ala Arg Arg Glu Ala Ile Val Asn Ala Gln Pro Lys Cys Asn 
465                 470                 475                 480 


Pro Asn Leu His Tyr Trp Thr Thr Gln Asp Glu Gly Ala Ala Ile Gly 
                485                 490                 495     


Leu Ala Trp Ile Pro Tyr Phe Gly Pro Ala Ala Glu Gly Ile Tyr Ile 
            500                 505                 510         


Glu Gly Leu Met His Asn Gln Asp Gly Leu Ile Cys Gly Leu Arg Gln 
        515                 520                 525             


Leu Ala Asn Glu Thr Thr Gln Ala Leu Gln Leu Phe Leu Arg Ala Thr 
    530                 535                 540                 


Thr Glu Leu Arg Thr Phe Ser Ile Leu Asn Arg Phe Ala Ile Asp Phe 
545                 550                 555                 560 


Leu Leu Gln Arg Trp Gly Gly Thr Cys His Ile Leu Gly Pro Asp Cys 
                565                 570                 575     


Cys Ile Glu Pro His Asp Trp Thr Lys Asn Ile Thr Asp Lys Ile Asp 
            580                 585                 590         


Gln Ile Ile His Asp Phe Val Asp Lys Thr Leu Pro Asp Gln Gly Asp 
        595                 600                 605             


Asn Asp Asn Trp Trp Thr Gly 
    610                 615 


<210> 22
<211> 615
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 22
Ile Pro Leu Gly Val Ile His Asn Ser Thr Leu Gln Val Ser Asp Val 
1               5                   10                  15      


Asp Lys Leu Val Cys Arg Asp Lys Leu Ser Ser Thr Asn Gln Leu Arg 
            20                  25                  30          


Ser Val Gly Leu Asn Leu Glu Gly Asn Gly Val Ala Thr Asp Val Pro 
        35                  40                  45              


Ser Ala Thr Lys Arg Trp Gly Phe Arg Ser Gly Val Pro Pro Lys Val 
    50                  55                  60                  


Val Asn Tyr Glu Ala Gly Glu Trp Ala Glu Asn Cys Tyr Asn Leu Glu 
65                  70                  75                  80  


Ile Lys Lys Pro Asp Gly Ser Glu Cys Leu Pro Ala Ala Pro Asp Gly 
                85                  90                  95      


Ile Arg Gly Phe Pro Arg Cys Arg Tyr Val His Lys Val Ser Gly Thr 
            100                 105                 110         


Gly Pro Cys Ala Gly Asp Phe Ala Phe His Lys Glu Gly Ala Phe Phe 
        115                 120                 125             


Leu Tyr Asp Arg Leu Ala Ser Thr Val Ile Tyr Arg Gly Thr Thr Phe 
    130                 135                 140                 


Ala Glu Gly Val Val Ala Phe Leu Ile Leu Pro Gln Ala Lys Lys Asp 
145                 150                 155                 160 


Phe Phe Ser Ser His Pro Leu Arg Glu Pro Val Asn Ala Thr Glu Asp 
                165                 170                 175     


Pro Ser Ser Gly Tyr Tyr Ser Thr Thr Ile Arg Tyr Gln Ala Thr Gly 
            180                 185                 190         


Phe Gly Thr Asn Glu Thr Glu Tyr Leu Phe Glu Val Asp Asn Leu Thr 
        195                 200                 205             


Tyr Val Gln Leu Glu Ser Arg Phe Thr Pro Gln Phe Leu Leu Gln Leu 
    210                 215                 220                 


Asn Glu Thr Ile Tyr Thr Ser Gly Lys Arg Ser Asn Thr Thr Gly Lys 
225                 230                 235                 240 


Leu Ile Trp Lys Val Asn Pro Glu Ile Asp Thr Thr Ile Gly Glu Trp 
                245                 250                 255     


Ala Phe Trp Glu Thr Lys Lys Asn Leu Thr Arg Lys Ile Arg Ser Glu 
            260                 265                 270         


Glu Leu Ser Phe Thr Ala Val Ser Asn Arg Ala Lys Asn Ile Ser Gly 
        275                 280                 285             


Gln Ser Pro Ala Arg Thr Ser Ser Asp Pro Gly Thr Asn Thr Thr Thr 
    290                 295                 300                 


Glu Asp His Lys Ile Met Ala Ser Glu Asn Ser Ser Ala Met Val Gln 
305                 310                 315                 320 


Val His Ser Gln Gly Arg Glu Ala Ala Val Ser His Leu Thr Thr Leu 
                325                 330                 335     


Ala Thr Ile Ser Thr Ser Pro Gln Pro Pro Thr Thr Lys Pro Gly Pro 
            340                 345                 350         


Asp Asn Ser Thr His Asn Thr Pro Val Tyr Lys Leu Asp Ile Ser Glu 
        355                 360                 365             


Ala Thr Gln Val Glu Gln His His Arg Arg Thr Asp Asn Asp Ser Thr 
    370                 375                 380                 


Ala Ser Asp Thr Pro Pro Ala Thr Thr Ala Ala Gly Pro Leu Lys Ala 
385                 390                 395                 400 


Glu Asn Thr Asn Thr Ser Lys Gly Thr Asp Leu Leu Asp Pro Ala Thr 
                405                 410                 415     


Thr Thr Ser Pro Gln Asn His Ser Glu Thr Ala Gly Asn Asn Asn Thr 
            420                 425                 430         


His His Gln Asp Thr Gly Glu Glu Ser Ala Ser Ser Gly Lys Leu Gly 
        435                 440                 445             


Leu Ile Thr Asn Thr Ile Ala Gly Val Ala Gly Leu Ile Thr Gly Gly 
    450                 455                 460                 


Arg Arg Ala Arg Arg Glu Ala Ile Val Asn Ala Gln Pro Lys Cys Asn 
465                 470                 475                 480 


Pro Asn Leu His Tyr Trp Thr Thr Gln Asp Glu Gly Ala Ala Ile Gly 
                485                 490                 495     


Leu Ala Trp Ile Pro Tyr Phe Gly Pro Ala Ala Glu Gly Ile Tyr Ile 
            500                 505                 510         


Glu Gly Leu Met His Asn Gln Asp Gly Leu Ile Cys Gly Leu Arg Gln 
        515                 520                 525             


Leu Ala Asn Glu Thr Thr Gln Ala Leu Gln Leu Phe Leu Arg Ala Thr 
    530                 535                 540                 


Pro Glu Leu Arg Thr Phe Ser Ile Leu Asn Arg Phe Ala Ile Asp Phe 
545                 550                 555                 560 


Leu Leu Gln Arg Trp Gly Gly Thr Cys His Ile Leu Gly Pro Asp Cys 
                565                 570                 575     


Cys Ile Glu Pro His Asp Trp Thr Lys Asn Ile Thr Asp Lys Ile Asp 
            580                 585                 590         


Gln Ile Ile His Asp Phe Val Asp Lys Thr Leu Pro Asp Gln Gly Asp 
        595                 600                 605             


Asn Asp Asn Trp Trp Thr Gly 
    610                 615 


<210> 23
<211> 456
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 23
Ile Pro Leu Gly Val Ile His Asn Ser Thr Leu Gln Val Ser Asp Val 
1               5                   10                  15      


Asp Lys Leu Val Cys Arg Asp Lys Leu Ser Ser Thr Asn Gln Leu Arg 
            20                  25                  30          


Ser Val Gly Leu Asn Leu Glu Gly Asn Gly Val Ala Thr Asp Val Pro 
        35                  40                  45              


Ser Ala Thr Lys Arg Trp Gly Phe Arg Ser Gly Val Pro Pro Lys Val 
    50                  55                  60                  


Val Asn Tyr Glu Ala Gly Glu Trp Ala Glu Asn Cys Tyr Asn Leu Glu 
65                  70                  75                  80  


Ile Lys Lys Pro Asp Gly Ser Glu Cys Leu Pro Ala Ala Pro Asp Gly 
                85                  90                  95      


Ile Arg Gly Phe Pro Arg Cys Arg Tyr Val His Lys Val Ser Gly Thr 
            100                 105                 110         


Gly Pro Cys Ala Gly Asp Phe Ala Phe His Lys Glu Gly Ala Phe Phe 
        115                 120                 125             


Leu Tyr Asp Arg Leu Ala Ser Thr Val Ile Tyr Arg Gly Thr Thr Phe 
    130                 135                 140                 


Ala Glu Gly Val Val Ala Phe Leu Ile Leu Pro Gln Ala Lys Lys Asp 
145                 150                 155                 160 


Phe Phe Ser Ser His Pro Leu Arg Glu Pro Val Asn Ala Thr Glu Asp 
                165                 170                 175     


Pro Ser Ser Gly Tyr Tyr Ser Thr Thr Ile Arg Tyr Gln Ala Thr Gly 
            180                 185                 190         


Phe Gly Thr Asn Glu Thr Glu Tyr Leu Phe Glu Val Asp Asn Leu Thr 
        195                 200                 205             


Tyr Val Gln Leu Glu Ser Arg Phe Thr Pro Gln Phe Leu Leu Gln Leu 
    210                 215                 220                 


Asn Glu Thr Ile Tyr Thr Ser Gly Lys Arg Ser Asn Thr Thr Gly Lys 
225                 230                 235                 240 


Leu Ile Trp Lys Val Asn Pro Glu Ile Asp Thr Thr Ile Gly Glu Trp 
                245                 250                 255     


Ala Phe Trp Glu Thr Lys Lys Asn Leu Thr Arg Lys Ile Arg Ser Glu 
            260                 265                 270         


Glu Leu Ser Phe Thr Ala Val Ser Asn Ser Ala Ser Ser Gly Lys Leu 
        275                 280                 285             


Gly Leu Ile Thr Asn Thr Ile Ala Gly Val Ala Gly Leu Ile Thr Gly 
    290                 295                 300                 


Gly Arg Arg Ala Arg Arg Glu Ala Ile Val Asn Ala Gln Pro Lys Cys 
305                 310                 315                 320 


Asn Pro Asn Leu His Tyr Trp Thr Thr Gln Asp Glu Gly Ala Ala Ile 
                325                 330                 335     


Gly Leu Ala Trp Ile Pro Tyr Phe Gly Pro Ala Ala Glu Gly Ile Tyr 
            340                 345                 350         


Ile Glu Gly Leu Met His Asn Gln Asp Gly Leu Ile Cys Gly Leu Arg 
        355                 360                 365             


Gln Leu Ala Asn Glu Thr Thr Gln Ala Leu Gln Leu Phe Leu Arg Ala 
    370                 375                 380                 


Thr Thr Glu Leu Arg Thr Phe Ser Ile Leu Asn Arg Lys Ala Ile Asp 
385                 390                 395                 400 


Phe Leu Leu Gln Arg Trp Gly Gly Thr Cys His Ile Leu Gly Pro Asp 
                405                 410                 415     


Cys Cys Ile Glu Pro His Asp Trp Thr Lys Asn Ile Thr Asp Lys Ile 
            420                 425                 430         


Asp Gln Ile Ile His Asp Phe Val Asp Lys Thr Leu Pro Asp Gln Gly 
        435                 440                 445             


Asp Asn Asp Asn Trp Trp Thr Gly 
    450                 455     


<210> 24
<211> 456
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 24
Ile Pro Leu Gly Val Ile His Asn Ser Thr Leu Gln Val Ser Asp Val 
1               5                   10                  15      


Asp Lys Leu Val Cys Arg Asp Lys Leu Ser Ser Thr Asn Gln Leu Arg 
            20                  25                  30          


Ser Val Gly Leu Asn Leu Glu Gly Asn Gly Val Ala Thr Asp Val Pro 
        35                  40                  45              


Ser Ala Thr Lys Arg Trp Gly Phe Arg Ser Gly Val Pro Pro Lys Val 
    50                  55                  60                  


Val Asn Tyr Glu Ala Gly Glu Trp Ala Glu Asn Cys Tyr Asn Leu Glu 
65                  70                  75                  80  


Ile Lys Lys Pro Asp Gly Ser Glu Cys Leu Pro Ala Ala Pro Asp Gly 
                85                  90                  95      


Ile Arg Gly Phe Pro Arg Cys Arg Tyr Val His Lys Val Ser Gly Thr 
            100                 105                 110         


Gly Pro Cys Ala Gly Asp Phe Ala Phe His Lys Glu Gly Ala Phe Phe 
        115                 120                 125             


Leu Tyr Asp Arg Leu Ala Ser Thr Val Ile Tyr Arg Gly Thr Thr Phe 
    130                 135                 140                 


Ala Glu Gly Val Val Ala Phe Leu Ile Leu Pro Gln Ala Lys Lys Asp 
145                 150                 155                 160 


Phe Phe Ser Ser His Pro Leu Arg Glu Pro Val Asn Ala Thr Glu Asp 
                165                 170                 175     


Pro Ser Ser Gly Tyr Tyr Ser Thr Thr Ile Arg Tyr Gln Ala Thr Gly 
            180                 185                 190         


Phe Gly Thr Asn Glu Thr Glu Tyr Leu Phe Glu Val Asp Asn Leu Thr 
        195                 200                 205             


Tyr Val Gln Leu Glu Ser Arg Phe Thr Pro Gln Phe Leu Leu Gln Leu 
    210                 215                 220                 


Asn Glu Thr Ile Tyr Thr Ser Gly Lys Arg Ser Asn Thr Thr Gly Lys 
225                 230                 235                 240 


Leu Ile Trp Lys Val Asn Pro Glu Ile Asp Thr Thr Ile Gly Glu Trp 
                245                 250                 255     


Ala Phe Trp Glu Thr Lys Lys Asn Leu Thr Arg Lys Ile Arg Ser Glu 
            260                 265                 270         


Glu Leu Ser Phe Thr Ala Val Ser Asn Ser Ala Ser Ser Gly Lys Leu 
        275                 280                 285             


Gly Leu Ile Thr Asn Thr Ile Ala Gly Val Ala Gly Leu Ile Thr Gly 
    290                 295                 300                 


Gly Arg Arg Ala Arg Arg Glu Ala Ile Val Asn Ala Gln Pro Lys Cys 
305                 310                 315                 320 


Asn Pro Asn Leu His Tyr Trp Thr Thr Gln Asp Glu Gly Ala Ala Ile 
                325                 330                 335     


Gly Leu Ala Trp Ile Pro Tyr Phe Gly Pro Ala Ala Glu Gly Ile Tyr 
            340                 345                 350         


Ile Glu Gly Leu Met His Asn Gln Asp Gly Leu Ile Cys Gly Leu Arg 
        355                 360                 365             


Gln Leu Ala Asn Glu Thr Thr Gln Ala Leu Gln Leu Phe Leu Arg Ala 
    370                 375                 380                 


Thr Pro Glu Leu Arg Thr Phe Ser Ile Leu Asn Arg Lys Ala Ile Asp 
385                 390                 395                 400 


Phe Leu Leu Gln Arg Trp Gly Gly Thr Cys His Ile Leu Gly Pro Asp 
                405                 410                 415     


Cys Cys Ile Glu Pro His Asp Trp Thr Lys Asn Ile Thr Asp Lys Ile 
            420                 425                 430         


Asp Gln Ile Ile His Asp Phe Val Asp Lys Thr Leu Pro Asp Gln Gly 
        435                 440                 445             


Asp Asn Asp Asn Trp Trp Thr Gly 
    450                 455     


<210> 25
<211> 456
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 25
Ile Pro Leu Gly Val Ile His Asn Ser Thr Leu Gln Val Ser Asp Val 
1               5                   10                  15      


Asp Lys Leu Val Cys Arg Asp Lys Leu Ser Ser Thr Asn Gln Leu Arg 
            20                  25                  30          


Ser Val Gly Leu Asn Leu Glu Gly Asn Gly Val Ala Thr Asp Val Pro 
        35                  40                  45              


Ser Ala Thr Lys Arg Trp Gly Phe Arg Ser Gly Val Pro Pro Lys Val 
    50                  55                  60                  


Val Asn Tyr Glu Ala Gly Glu Trp Ala Glu Asn Cys Tyr Asn Leu Glu 
65                  70                  75                  80  


Ile Lys Lys Pro Asp Gly Ser Glu Cys Leu Pro Ala Ala Pro Asp Gly 
                85                  90                  95      


Ile Arg Gly Phe Pro Arg Cys Arg Tyr Val His Lys Val Ser Gly Thr 
            100                 105                 110         


Gly Pro Cys Ala Gly Asp Phe Ala Phe His Lys Glu Gly Ala Phe Phe 
        115                 120                 125             


Leu Tyr Asp Arg Leu Ala Ser Thr Val Ile Tyr Arg Gly Thr Thr Phe 
    130                 135                 140                 


Ala Glu Gly Val Val Ala Phe Leu Ile Leu Pro Gln Ala Lys Lys Asp 
145                 150                 155                 160 


Phe Phe Ser Ser His Pro Leu Arg Glu Pro Val Asn Ala Thr Glu Asp 
                165                 170                 175     


Pro Ser Ser Gly Tyr Tyr Ser Thr Thr Ile Arg Tyr Gln Ala Thr Gly 
            180                 185                 190         


Phe Gly Thr Asn Glu Thr Glu Tyr Leu Phe Glu Val Asp Asn Leu Thr 
        195                 200                 205             


Tyr Val Gln Leu Glu Ser Arg Phe Thr Pro Gln Phe Leu Leu Gln Leu 
    210                 215                 220                 


Asn Glu Thr Ile Tyr Thr Ser Gly Lys Arg Ser Asn Thr Thr Gly Lys 
225                 230                 235                 240 


Leu Ile Trp Lys Val Asn Pro Glu Ile Asp Thr Thr Ile Gly Glu Trp 
                245                 250                 255     


Ala Phe Trp Glu Thr Lys Lys Asn Leu Thr Arg Lys Ile Arg Ser Glu 
            260                 265                 270         


Glu Leu Ser Phe Thr Ala Val Ser Asn Ser Ala Ser Ser Gly Lys Leu 
        275                 280                 285             


Gly Leu Ile Thr Asn Thr Ile Ala Gly Val Ala Gly Leu Ile Thr Gly 
    290                 295                 300                 


Gly Arg Arg Ala Arg Arg Glu Ala Ile Val Asn Ala Gln Pro Lys Cys 
305                 310                 315                 320 


Asn Pro Asn Leu His Tyr Trp Thr Thr Gln Asp Glu Gly Ala Ala Ile 
                325                 330                 335     


Gly Leu Ala Trp Ile Pro Tyr Phe Gly Pro Ala Ala Glu Gly Ile Tyr 
            340                 345                 350         


Ile Glu Gly Leu Met His Asn Gln Asp Gly Leu Ile Cys Gly Leu Arg 
        355                 360                 365             


Gln Leu Ala Asn Glu Thr Thr Gln Ala Leu Gln Leu Phe Leu Arg Ala 
    370                 375                 380                 


Thr Thr Glu Leu Arg Thr Phe Ser Ile Leu Asn Arg Phe Ala Ile Asp 
385                 390                 395                 400 


Phe Leu Leu Gln Arg Trp Gly Gly Thr Cys His Ile Leu Gly Pro Asp 
                405                 410                 415     


Cys Cys Ile Glu Pro His Asp Trp Thr Lys Asn Ile Thr Asp Lys Ile 
            420                 425                 430         


Asp Gln Ile Ile His Asp Phe Val Asp Lys Thr Leu Pro Asp Gln Gly 
        435                 440                 445             


Asp Asn Asp Asn Trp Trp Thr Gly 
    450                 455     


<210> 26
<211> 456
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 26
Ile Pro Leu Gly Val Ile His Asn Ser Thr Leu Gln Val Ser Asp Val 
1               5                   10                  15      


Asp Lys Leu Val Cys Arg Asp Lys Leu Ser Ser Thr Asn Gln Leu Arg 
            20                  25                  30          


Ser Val Gly Leu Asn Leu Glu Gly Asn Gly Val Ala Thr Asp Val Pro 
        35                  40                  45              


Ser Ala Thr Lys Arg Trp Gly Phe Arg Ser Gly Val Pro Pro Lys Val 
    50                  55                  60                  


Val Asn Tyr Glu Ala Gly Glu Trp Ala Glu Asn Cys Tyr Asn Leu Glu 
65                  70                  75                  80  


Ile Lys Lys Pro Asp Gly Ser Glu Cys Leu Pro Ala Ala Pro Asp Gly 
                85                  90                  95      


Ile Arg Gly Phe Pro Arg Cys Arg Tyr Val His Lys Val Ser Gly Thr 
            100                 105                 110         


Gly Pro Cys Ala Gly Asp Phe Ala Phe His Lys Glu Gly Ala Phe Phe 
        115                 120                 125             


Leu Tyr Asp Arg Leu Ala Ser Thr Val Ile Tyr Arg Gly Thr Thr Phe 
    130                 135                 140                 


Ala Glu Gly Val Val Ala Phe Leu Ile Leu Pro Gln Ala Lys Lys Asp 
145                 150                 155                 160 


Phe Phe Ser Ser His Pro Leu Arg Glu Pro Val Asn Ala Thr Glu Asp 
                165                 170                 175     


Pro Ser Ser Gly Tyr Tyr Ser Thr Thr Ile Arg Tyr Gln Ala Thr Gly 
            180                 185                 190         


Phe Gly Thr Asn Glu Thr Glu Tyr Leu Phe Glu Val Asp Asn Leu Thr 
        195                 200                 205             


Tyr Val Gln Leu Glu Ser Arg Phe Thr Pro Gln Phe Leu Leu Gln Leu 
    210                 215                 220                 


Asn Glu Thr Ile Tyr Thr Ser Gly Lys Arg Ser Asn Thr Thr Gly Lys 
225                 230                 235                 240 


Leu Ile Trp Lys Val Asn Pro Glu Ile Asp Thr Thr Ile Gly Glu Trp 
                245                 250                 255     


Ala Phe Trp Glu Thr Lys Lys Asn Leu Thr Arg Lys Ile Arg Ser Glu 
            260                 265                 270         


Glu Leu Ser Phe Thr Ala Val Ser Asn Ser Ala Ser Ser Gly Lys Leu 
        275                 280                 285             


Gly Leu Ile Thr Asn Thr Ile Ala Gly Val Ala Gly Leu Ile Thr Gly 
    290                 295                 300                 


Gly Arg Arg Ala Arg Arg Glu Ala Ile Val Asn Ala Gln Pro Lys Cys 
305                 310                 315                 320 


Asn Pro Asn Leu His Tyr Trp Thr Thr Gln Asp Glu Gly Ala Ala Ile 
                325                 330                 335     


Gly Leu Ala Trp Ile Pro Tyr Phe Gly Pro Ala Ala Glu Gly Ile Tyr 
            340                 345                 350         


Ile Glu Gly Leu Met His Asn Gln Asp Gly Leu Ile Cys Gly Leu Arg 
        355                 360                 365             


Gln Leu Ala Asn Glu Thr Thr Gln Ala Leu Gln Leu Phe Leu Arg Ala 
    370                 375                 380                 


Thr Pro Glu Leu Arg Thr Phe Ser Ile Leu Asn Arg Phe Ala Ile Asp 
385                 390                 395                 400 


Phe Leu Leu Gln Arg Trp Gly Gly Thr Cys His Ile Leu Gly Pro Asp 
                405                 410                 415     


Cys Cys Ile Glu Pro His Asp Trp Thr Lys Asn Ile Thr Asp Lys Ile 
            420                 425                 430         


Asp Gln Ile Ile His Asp Phe Val Asp Lys Thr Leu Pro Asp Gln Gly 
        435                 440                 445             


Asp Asn Asp Asn Trp Trp Thr Gly 
    450                 455     


<210> 27
<211> 450
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 27
Leu Pro Val Leu Glu Ile Ala Ser Asn Ser Gln Pro Gln Asp Val Asp 
1               5                   10                  15      


Ser Val Cys Ser Gly Thr Leu Gln Lys Thr Glu Asp Val His Leu Met 
            20                  25                  30          


Gly Phe Thr Leu Ser Gly Gln Lys Val Ala Asp Ser Pro Leu Glu Ala 
        35                  40                  45              


Ser Lys Arg Trp Ala Phe Arg Thr Gly Val Pro Pro Lys Asn Val Glu 
    50                  55                  60                  


Tyr Thr Glu Gly Glu Glu Ala Lys Thr Cys Tyr Asn Ile Ser Val Thr 
65                  70                  75                  80  


Asp Pro Ser Gly Lys Ser Leu Leu Leu Asp Pro Pro Ser Asn Ile Arg 
                85                  90                  95      


Asp Tyr Pro Lys Cys Lys Thr Val His His Ile Gln Gly Gln Asn Pro 
            100                 105                 110         


His Ala Gln Gly Ile Ala Leu His Leu Trp Gly Ala Phe Phe Leu Tyr 
        115                 120                 125             


Asp Arg Val Ala Ser Thr Thr Met Tyr Arg Gly Lys Val Phe Thr Glu 
    130                 135                 140                 


Gly Asn Ile Ala Ala Met Ile Val Asn Lys Thr Val His Arg Met Ile 
145                 150                 155                 160 


Phe Ser Arg Gln Gly Gln Gly Tyr Arg His Met Asn Leu Thr Ser Thr 
                165                 170                 175     


Asn Lys Tyr Trp Thr Ser Ser Asn Glu Thr Gln Arg Asn Asp Thr Gly 
            180                 185                 190         


Cys Phe Gly Ile Leu Gln Glu Tyr Asn Ser Thr Asn Asn Gln Thr Cys 
        195                 200                 205             


Pro Pro Ser Leu Lys Pro Pro Ser Leu Pro Thr Val Thr Pro Ser Ile 
    210                 215                 220                 


His Ser Thr Asn Thr Gln Ile Asn Thr Ala Lys Ser Gly Thr Arg Pro 
225                 230                 235                 240 


Pro Ile Tyr Phe Arg Lys Lys Arg Ser Ile Leu Ala Lys Glu Gly Asp 
                245                 250                 255     


Ile Gly Pro Asn Leu Asp Gly Leu Ile Asn Thr Glu Ile Asp Phe Asp 
            260                 265                 270         


Pro Ile Pro Asn Thr Glu Thr Ile Phe Asp Glu Ser Pro Ser Phe Asn 
        275                 280                 285             


Thr Ser Thr Asn Glu Glu Gln His Thr Pro Pro Asn Ile Ser Leu Thr 
    290                 295                 300                 


Phe Ser Tyr Phe Pro Asp Lys Asn Gly Asp Thr Ala Tyr Ser Gly Glu 
305                 310                 315                 320 


Asn Glu Asn Asp Cys Asp Ala Glu Leu Arg Ile Trp Ser Val Gln Glu 
                325                 330                 335     


Asp Asp Leu Ala Ala Gly Leu Ser Trp Ile Pro Phe Phe Gly Pro Gly 
            340                 345                 350         


Ile Glu Gly Leu Tyr Thr Ala Gly Leu Ile Lys Asn Gln Asn Asn Leu 
        355                 360                 365             


Val Cys Arg Leu Arg Arg Leu Ala Asn Gln Thr Ala Lys Ser Leu Glu 
    370                 375                 380                 


Leu Leu Leu Arg Val Thr Thr Glu Glu Arg Thr Phe Ser Leu Ile Asn 
385                 390                 395                 400 


Arg His Ala Ile Asp Phe Leu Leu Thr Arg Trp Gly Gly Thr Cys Lys 
                405                 410                 415     


Val Leu Gly Pro Asp Cys Cys Ile Gly Ile Glu Asp Leu Ser Lys Asn 
            420                 425                 430         


Ile Ser Glu Gln Ile Asp Lys Ile Arg Lys Asp Glu Gln Lys Glu Glu 
        435                 440                 445             


Thr Gly 
    450 


<210> 28
<211> 615
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 28
Ile Pro Leu Gly Val Ile His Asn Ser Thr Leu Gln Val Ser Asp Val 
1               5                   10                  15      


Asp Lys Leu Val Cys Arg Asp Lys Leu Ser Ser Thr Asn Gln Leu Arg 
            20                  25                  30          


Ser Val Gly Leu Asn Leu Glu Gly Asn Gly Val Ala Thr Asp Val Pro 
        35                  40                  45              


Ser Ala Thr Lys Arg Trp Gly Phe Arg Ser Gly Val Pro Pro Lys Val 
    50                  55                  60                  


Val Asn Tyr Glu Ala Gly Glu Trp Ala Glu Asn Cys Tyr Asn Leu Glu 
65                  70                  75                  80  


Ile Lys Lys Pro Asp Gly Ser Glu Cys Leu Pro Ala Ala Pro Asp Gly 
                85                  90                  95      


Ile Arg Gly Phe Pro Arg Cys Arg Tyr Val His Lys Val Ser Gly Thr 
            100                 105                 110         


Gly Pro Cys Ala Gly Asp Phe Ala Phe His Lys Glu Gly Ala Phe Phe 
        115                 120                 125             


Leu Tyr Asp Arg Leu Ala Ser Thr Val Ile Tyr Arg Gly Thr Thr Phe 
    130                 135                 140                 


Ala Glu Gly Val Val Ala Phe Leu Ile Leu Pro Gln Ala Lys Lys Asp 
145                 150                 155                 160 


Phe Phe Ser Ser His Pro Leu Arg Glu Pro Val Asn Ala Thr Glu Asp 
                165                 170                 175     


Pro Ser Ser Gly Tyr Tyr Ser Thr Thr Ile Arg Tyr Gln Ala Thr Gly 
            180                 185                 190         


Phe Gly Thr Asn Glu Thr Glu Tyr Leu Phe Glu Val Asp Asn Leu Thr 
        195                 200                 205             


Tyr Val Gln Leu Glu Ser Arg Phe Thr Pro Gln Phe Leu Leu Gln Leu 
    210                 215                 220                 


Asn Glu Thr Ile Tyr Thr Ser Gly Lys Arg Ser Asn Thr Thr Gly Lys 
225                 230                 235                 240 


Leu Ile Trp Lys Val Asn Pro Glu Ile Asp Thr Thr Ile Gly Glu Trp 
                245                 250                 255     


Ala Phe Trp Glu Thr Lys Lys Asn Leu Thr Arg Lys Ile Arg Ser Glu 
            260                 265                 270         


Glu Leu Ser Phe Thr Val Val Ser Asn Gly Ala Lys Asn Ile Ser Gly 
        275                 280                 285             


Gln Ser Pro Ala Arg Thr Ser Ser Asp Pro Gly Thr Asn Thr Thr Thr 
    290                 295                 300                 


Glu Asp His Lys Ile Met Ala Ser Glu Asn Ser Ser Ala Met Val Gln 
305                 310                 315                 320 


Val His Ser Gln Gly Arg Glu Ala Ala Val Ser His Leu Thr Thr Leu 
                325                 330                 335     


Ala Thr Ile Ser Thr Ser Pro Gln Ser Leu Thr Thr Lys Pro Gly Pro 
            340                 345                 350         


Asp Asn Ser Thr His Asn Thr Pro Val Tyr Lys Leu Asp Ile Ser Glu 
        355                 360                 365             


Ala Thr Gln Val Glu Gln His His Arg Arg Thr Asp Asn Asp Ser Thr 
    370                 375                 380                 


Ala Ser Asp Thr Pro Ser Ala Thr Thr Ala Ala Gly Pro Pro Lys Ala 
385                 390                 395                 400 


Glu Asn Thr Asn Thr Ser Lys Ser Thr Asp Phe Leu Asp Pro Ala Thr 
                405                 410                 415     


Thr Thr Ser Pro Gln Asn His Ser Glu Thr Ala Gly Asn Asn Asn Thr 
            420                 425                 430         


His His Gln Asp Thr Gly Glu Glu Ser Ala Ser Ser Gly Lys Leu Gly 
        435                 440                 445             


Leu Ile Thr Asn Thr Ile Ala Gly Val Ala Gly Leu Ile Thr Gly Gly 
    450                 455                 460                 


Arg Arg Thr Arg Arg Glu Ala Ile Val Asn Ala Gln Pro Lys Cys Asn 
465                 470                 475                 480 


Pro Asn Leu His Tyr Trp Thr Thr Gln Asp Glu Gly Ala Ala Ile Gly 
                485                 490                 495     


Leu Ala Trp Ile Pro Tyr Phe Gly Pro Ala Ala Glu Gly Ile Tyr Ile 
            500                 505                 510         


Glu Gly Leu Met His Asn Gln Asp Gly Leu Ile Cys Gly Leu Arg Gln 
        515                 520                 525             


Leu Ala Asn Glu Thr Thr Gln Ala Leu Gln Leu Phe Leu Arg Ala Thr 
    530                 535                 540                 


Thr Glu Leu Arg Thr Phe Ser Ile Leu Asn Arg Ala Ala Ile Asp Phe 
545                 550                 555                 560 


Leu Leu Gln Arg Trp Gly Gly Thr Cys His Ile Leu Gly Pro Asp Cys 
                565                 570                 575     


Cys Ile Glu Pro His Asp Trp Thr Lys Asn Ile Thr Asp Lys Ile Asp 
            580                 585                 590         


Gln Ile Ile His Asp Phe Val Asp Lys Thr Leu Pro Asp Gln Gly Asp 
        595                 600                 605             


Asn Asp Asn Trp Trp Thr Gly 
    610                 615 


<210> 29
<211> 615
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 29
Ile Pro Leu Gly Val Ile His Asn Ser Thr Leu Gln Val Ser Asp Val 
1               5                   10                  15      


Asp Lys Leu Val Cys Arg Asp Lys Leu Ser Ser Thr Asn Gln Leu Arg 
            20                  25                  30          


Ser Val Gly Leu Asn Leu Glu Gly Asn Gly Val Ala Thr Asp Val Pro 
        35                  40                  45              


Ser Ala Thr Lys Arg Trp Gly Phe Arg Ser Gly Val Pro Pro Lys Val 
    50                  55                  60                  


Val Asn Tyr Glu Ala Gly Glu Trp Ala Glu Asn Cys Tyr Asn Leu Glu 
65                  70                  75                  80  


Ile Lys Lys Pro Asp Gly Ser Glu Cys Leu Pro Ala Ala Pro Asp Gly 
                85                  90                  95      


Ile Arg Gly Phe Pro Arg Cys Arg Tyr Val His Lys Val Ser Gly Thr 
            100                 105                 110         


Gly Pro Cys Ala Gly Asp Phe Ala Phe His Lys Glu Gly Ala Phe Phe 
        115                 120                 125             


Leu Tyr Asp Arg Leu Ala Ser Thr Val Ile Tyr Arg Gly Thr Thr Phe 
    130                 135                 140                 


Ala Glu Gly Val Val Ala Phe Leu Ile Leu Pro Gln Ala Lys Lys Asp 
145                 150                 155                 160 


Phe Phe Ser Ser His Pro Leu Arg Glu Pro Val Asn Ala Thr Glu Asp 
                165                 170                 175     


Pro Ser Ser Gly Tyr Tyr Ser Thr Thr Ile Arg Tyr Gln Ala Thr Gly 
            180                 185                 190         


Phe Gly Thr Asn Glu Thr Glu Tyr Leu Phe Glu Val Asp Asn Leu Thr 
        195                 200                 205             


Tyr Val Gln Leu Glu Ser Arg Phe Thr Pro Gln Phe Leu Leu Gln Leu 
    210                 215                 220                 


Asn Glu Thr Ile Tyr Thr Ser Gly Lys Arg Ser Asn Thr Thr Gly Lys 
225                 230                 235                 240 


Leu Ile Trp Lys Val Asn Pro Glu Ile Asp Thr Thr Ile Gly Glu Trp 
                245                 250                 255     


Ala Phe Trp Glu Thr Lys Lys Asn Leu Thr Arg Lys Ile Arg Ser Glu 
            260                 265                 270         


Glu Leu Ser Phe Thr Val Val Ser Asn Gly Ala Lys Asn Ile Ser Gly 
        275                 280                 285             


Gln Ser Pro Ala Arg Thr Ser Ser Asp Pro Gly Thr Asn Thr Thr Thr 
    290                 295                 300                 


Glu Asp His Lys Ile Met Ala Ser Glu Asn Ser Ser Ala Met Val Gln 
305                 310                 315                 320 


Val His Ser Gln Gly Arg Glu Ala Ala Val Ser His Leu Thr Thr Leu 
                325                 330                 335     


Ala Thr Ile Ser Thr Ser Pro Gln Ser Leu Thr Thr Lys Pro Gly Pro 
            340                 345                 350         


Asp Asn Ser Thr His Asn Thr Pro Val Tyr Lys Leu Asp Ile Ser Glu 
        355                 360                 365             


Ala Thr Gln Val Glu Gln His His Arg Arg Thr Asp Asn Asp Ser Thr 
    370                 375                 380                 


Ala Ser Asp Thr Pro Ser Ala Thr Thr Ala Ala Gly Pro Pro Lys Ala 
385                 390                 395                 400 


Glu Asn Thr Asn Thr Ser Lys Ser Thr Asp Phe Leu Asp Pro Ala Thr 
                405                 410                 415     


Thr Thr Ser Pro Gln Asn His Ser Glu Thr Ala Gly Asn Asn Asn Thr 
            420                 425                 430         


His His Gln Asp Thr Gly Glu Glu Ser Ala Ser Ser Gly Lys Leu Gly 
        435                 440                 445             


Leu Ile Thr Asn Thr Ile Ala Gly Val Ala Gly Leu Ile Thr Gly Gly 
    450                 455                 460                 


Arg Arg Thr Arg Arg Glu Ala Ile Val Asn Ala Gln Pro Lys Cys Asn 
465                 470                 475                 480 


Pro Asn Leu His Tyr Trp Thr Thr Gln Asp Glu Gly Ala Ala Ile Gly 
                485                 490                 495     


Leu Ala Trp Ile Pro Tyr Phe Gly Pro Ala Ala Glu Gly Ile Tyr Ile 
            500                 505                 510         


Glu Gly Leu Met His Asn Gln Asp Gly Leu Ile Cys Gly Leu Arg Gln 
        515                 520                 525             


Leu Ala Asn Glu Thr Thr Gln Ala Leu Gln Leu Phe Leu Arg Ala Thr 
    530                 535                 540                 


Thr Glu Leu Arg Thr Phe Ser Ile Leu Asn Arg Val Ala Ile Asp Phe 
545                 550                 555                 560 


Leu Leu Gln Arg Trp Gly Gly Thr Cys His Ile Leu Gly Pro Asp Cys 
                565                 570                 575     


Cys Ile Glu Pro His Asp Trp Thr Lys Asn Ile Thr Asp Lys Ile Asp 
            580                 585                 590         


Gln Ile Ile His Asp Phe Val Asp Lys Thr Leu Pro Asp Gln Gly Asp 
        595                 600                 605             


Asn Asp Asn Trp Trp Thr Gly 
    610                 615 


<210> 30
<211> 615
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 30
Ile Pro Leu Gly Val Ile His Asn Ser Thr Leu Gln Val Ser Asp Val 
1               5                   10                  15      


Asp Lys Leu Val Cys Arg Asp Lys Leu Ser Ser Thr Asn Gln Leu Arg 
            20                  25                  30          


Ser Val Gly Leu Asn Leu Glu Gly Asn Gly Val Ala Thr Asp Val Pro 
        35                  40                  45              


Ser Ala Thr Lys Arg Trp Gly Phe Arg Ser Gly Val Pro Pro Lys Val 
    50                  55                  60                  


Val Asn Tyr Glu Ala Gly Glu Trp Ala Glu Asn Cys Tyr Asn Leu Glu 
65                  70                  75                  80  


Ile Lys Lys Pro Asp Gly Ser Glu Cys Leu Pro Ala Ala Pro Asp Gly 
                85                  90                  95      


Ile Arg Gly Phe Pro Arg Cys Arg Tyr Val His Lys Val Ser Gly Thr 
            100                 105                 110         


Gly Pro Cys Ala Gly Asp Phe Ala Phe His Lys Glu Gly Ala Phe Phe 
        115                 120                 125             


Leu Tyr Asp Arg Leu Ala Ser Thr Val Ile Tyr Arg Gly Thr Thr Phe 
    130                 135                 140                 


Ala Glu Gly Val Val Ala Phe Leu Ile Leu Pro Gln Ala Lys Lys Asp 
145                 150                 155                 160 


Phe Phe Ser Ser His Pro Leu Arg Glu Pro Val Asn Ala Thr Glu Asp 
                165                 170                 175     


Pro Ser Ser Gly Tyr Tyr Ser Thr Thr Ile Arg Tyr Gln Ala Thr Gly 
            180                 185                 190         


Phe Gly Thr Asn Glu Thr Glu Tyr Leu Phe Glu Val Asp Asn Leu Thr 
        195                 200                 205             


Tyr Val Gln Leu Glu Ser Arg Phe Thr Pro Gln Phe Leu Leu Gln Leu 
    210                 215                 220                 


Asn Glu Thr Ile Tyr Thr Ser Gly Lys Arg Ser Asn Thr Thr Gly Lys 
225                 230                 235                 240 


Leu Ile Trp Lys Val Asn Pro Glu Ile Asp Thr Thr Ile Gly Glu Trp 
                245                 250                 255     


Ala Phe Trp Glu Thr Lys Lys Asn Leu Thr Arg Lys Ile Arg Ser Glu 
            260                 265                 270         


Glu Leu Ser Phe Thr Val Val Ser Asn Gly Ala Lys Asn Ile Ser Gly 
        275                 280                 285             


Gln Ser Pro Ala Arg Thr Ser Ser Asp Pro Gly Thr Asn Thr Thr Thr 
    290                 295                 300                 


Glu Asp His Lys Ile Met Ala Ser Glu Asn Ser Ser Ala Met Val Gln 
305                 310                 315                 320 


Val His Ser Gln Gly Arg Glu Ala Ala Val Ser His Leu Thr Thr Leu 
                325                 330                 335     


Ala Thr Ile Ser Thr Ser Pro Gln Ser Leu Thr Thr Lys Pro Gly Pro 
            340                 345                 350         


Asp Asn Ser Thr His Asn Thr Pro Val Tyr Lys Leu Asp Ile Ser Glu 
        355                 360                 365             


Ala Thr Gln Val Glu Gln His His Arg Arg Thr Asp Asn Asp Ser Thr 
    370                 375                 380                 


Ala Ser Asp Thr Pro Ser Ala Thr Thr Ala Ala Gly Pro Pro Lys Ala 
385                 390                 395                 400 


Glu Asn Thr Asn Thr Ser Lys Ser Thr Asp Phe Leu Asp Pro Ala Thr 
                405                 410                 415     


Thr Thr Ser Pro Gln Asn His Ser Glu Thr Ala Gly Asn Asn Asn Thr 
            420                 425                 430         


His His Gln Asp Thr Gly Glu Glu Ser Ala Ser Ser Gly Lys Leu Gly 
        435                 440                 445             


Leu Ile Thr Asn Thr Ile Ala Gly Val Ala Gly Leu Ile Thr Gly Gly 
    450                 455                 460                 


Arg Arg Thr Arg Arg Glu Ala Ile Val Asn Ala Gln Pro Lys Cys Asn 
465                 470                 475                 480 


Pro Asn Leu His Tyr Trp Thr Thr Gln Asp Glu Gly Ala Ala Ile Gly 
                485                 490                 495     


Leu Ala Trp Ile Pro Tyr Phe Gly Pro Ala Ala Glu Gly Ile Tyr Ile 
            500                 505                 510         


Glu Gly Leu Met His Asn Gln Asp Gly Leu Ile Cys Gly Leu Arg Gln 
        515                 520                 525             


Leu Ala Asn Glu Thr Thr Gln Ala Leu Gln Leu Phe Leu Arg Ala Thr 
    530                 535                 540                 


Thr Glu Leu Arg Thr Phe Ser Ile Leu Asn Arg Ile Ala Ile Asp Phe 
545                 550                 555                 560 


Leu Leu Gln Arg Trp Gly Gly Thr Cys His Ile Leu Gly Pro Asp Cys 
                565                 570                 575     


Cys Ile Glu Pro His Asp Trp Thr Lys Asn Ile Thr Asp Lys Ile Asp 
            580                 585                 590         


Gln Ile Ile His Asp Phe Val Asp Lys Thr Leu Pro Asp Gln Gly Asp 
        595                 600                 605             


Asn Asp Asn Trp Trp Thr Gly 
    610                 615 


<210> 31
<211> 615
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 31
Ile Pro Leu Gly Val Ile His Asn Ser Thr Leu Gln Val Ser Asp Val 
1               5                   10                  15      


Asp Lys Leu Val Cys Arg Asp Lys Leu Ser Ser Thr Asn Gln Leu Arg 
            20                  25                  30          


Ser Val Gly Leu Asn Leu Glu Gly Asn Gly Val Ala Thr Asp Val Pro 
        35                  40                  45              


Ser Ala Thr Lys Arg Trp Gly Phe Arg Ser Gly Val Pro Pro Lys Val 
    50                  55                  60                  


Val Asn Tyr Glu Ala Gly Glu Trp Ala Glu Asn Cys Tyr Asn Leu Glu 
65                  70                  75                  80  


Ile Lys Lys Pro Asp Gly Ser Glu Cys Leu Pro Ala Ala Pro Asp Gly 
                85                  90                  95      


Ile Arg Gly Phe Pro Arg Cys Arg Tyr Val His Lys Val Ser Gly Thr 
            100                 105                 110         


Gly Pro Cys Ala Gly Asp Phe Ala Phe His Lys Glu Gly Ala Phe Phe 
        115                 120                 125             


Leu Tyr Asp Arg Leu Ala Ser Thr Val Ile Tyr Arg Gly Thr Thr Phe 
    130                 135                 140                 


Ala Glu Gly Val Val Ala Phe Leu Ile Leu Pro Gln Ala Lys Lys Asp 
145                 150                 155                 160 


Phe Phe Ser Ser His Pro Leu Arg Glu Pro Val Asn Ala Thr Glu Asp 
                165                 170                 175     


Pro Ser Ser Gly Tyr Tyr Ser Thr Thr Ile Arg Tyr Gln Ala Thr Gly 
            180                 185                 190         


Phe Gly Thr Asn Glu Thr Glu Tyr Leu Phe Glu Val Asp Asn Leu Thr 
        195                 200                 205             


Tyr Val Gln Leu Glu Ser Arg Phe Thr Pro Gln Phe Leu Leu Gln Leu 
    210                 215                 220                 


Asn Glu Thr Ile Tyr Thr Ser Gly Lys Arg Ser Asn Thr Thr Gly Lys 
225                 230                 235                 240 


Leu Ile Trp Lys Val Asn Pro Glu Ile Asp Thr Thr Ile Gly Glu Trp 
                245                 250                 255     


Ala Phe Trp Glu Thr Lys Lys Asn Leu Thr Arg Lys Ile Arg Ser Glu 
            260                 265                 270         


Glu Leu Ser Phe Thr Val Val Ser Asn Gly Ala Lys Asn Ile Ser Gly 
        275                 280                 285             


Gln Ser Pro Ala Arg Thr Ser Ser Asp Pro Gly Thr Asn Thr Thr Thr 
    290                 295                 300                 


Glu Asp His Lys Ile Met Ala Ser Glu Asn Ser Ser Ala Met Val Gln 
305                 310                 315                 320 


Val His Ser Gln Gly Arg Glu Ala Ala Val Ser His Leu Thr Thr Leu 
                325                 330                 335     


Ala Thr Ile Ser Thr Ser Pro Gln Ser Leu Thr Thr Lys Pro Gly Pro 
            340                 345                 350         


Asp Asn Ser Thr His Asn Thr Pro Val Tyr Lys Leu Asp Ile Ser Glu 
        355                 360                 365             


Ala Thr Gln Val Glu Gln His His Arg Arg Thr Asp Asn Asp Ser Thr 
    370                 375                 380                 


Ala Ser Asp Thr Pro Ser Ala Thr Thr Ala Ala Gly Pro Pro Lys Ala 
385                 390                 395                 400 


Glu Asn Thr Asn Thr Ser Lys Ser Thr Asp Phe Leu Asp Pro Ala Thr 
                405                 410                 415     


Thr Thr Ser Pro Gln Asn His Ser Glu Thr Ala Gly Asn Asn Asn Thr 
            420                 425                 430         


His His Gln Asp Thr Gly Glu Glu Ser Ala Ser Ser Gly Lys Leu Gly 
        435                 440                 445             


Leu Ile Thr Asn Thr Ile Ala Gly Val Ala Gly Leu Ile Thr Gly Gly 
    450                 455                 460                 


Arg Arg Thr Arg Arg Glu Ala Ile Val Asn Ala Gln Pro Lys Cys Asn 
465                 470                 475                 480 


Pro Asn Leu His Tyr Trp Thr Thr Gln Asp Glu Gly Ala Ala Ile Gly 
                485                 490                 495     


Leu Ala Trp Ile Pro Tyr Phe Gly Pro Ala Ala Glu Gly Ile Tyr Ile 
            500                 505                 510         


Glu Gly Leu Met His Asn Gln Asp Gly Leu Ile Cys Gly Leu Arg Gln 
        515                 520                 525             


Leu Ala Asn Glu Thr Thr Gln Ala Leu Gln Leu Phe Leu Arg Ala Thr 
    530                 535                 540                 


Thr Glu Leu Arg Thr Phe Ser Ile Leu Asn Arg Leu Ala Ile Asp Phe 
545                 550                 555                 560 


Leu Leu Gln Arg Trp Gly Gly Thr Cys His Ile Leu Gly Pro Asp Cys 
                565                 570                 575     


Cys Ile Glu Pro His Asp Trp Thr Lys Asn Ile Thr Asp Lys Ile Asp 
            580                 585                 590         


Gln Ile Ile His Asp Phe Val Asp Lys Thr Leu Pro Asp Gln Gly Asp 
        595                 600                 605             


Asn Asp Asn Trp Trp Thr Gly 
    610                 615 


<210> 32
<211> 615
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 32
Ile Pro Leu Gly Val Ile His Asn Ser Thr Leu Gln Val Ser Asp Val 
1               5                   10                  15      


Asp Lys Leu Val Cys Arg Asp Lys Leu Ser Ser Thr Asn Gln Leu Arg 
            20                  25                  30          


Ser Val Gly Leu Asn Leu Glu Gly Asn Gly Val Ala Thr Asp Val Pro 
        35                  40                  45              


Ser Ala Thr Lys Arg Trp Gly Phe Arg Ser Gly Val Pro Pro Lys Val 
    50                  55                  60                  


Val Asn Tyr Glu Ala Gly Glu Trp Ala Glu Asn Cys Tyr Asn Leu Glu 
65                  70                  75                  80  


Ile Lys Lys Pro Asp Gly Ser Glu Cys Leu Pro Ala Ala Pro Asp Gly 
                85                  90                  95      


Ile Arg Gly Phe Pro Arg Cys Arg Tyr Val His Lys Val Ser Gly Thr 
            100                 105                 110         


Gly Pro Cys Ala Gly Asp Phe Ala Phe His Lys Glu Gly Ala Phe Phe 
        115                 120                 125             


Leu Tyr Asp Arg Leu Ala Ser Thr Val Ile Tyr Arg Gly Thr Thr Phe 
    130                 135                 140                 


Ala Glu Gly Val Val Ala Phe Leu Ile Leu Pro Gln Ala Lys Lys Asp 
145                 150                 155                 160 


Phe Phe Ser Ser His Pro Leu Arg Glu Pro Val Asn Ala Thr Glu Asp 
                165                 170                 175     


Pro Ser Ser Gly Tyr Tyr Ser Thr Thr Ile Arg Tyr Gln Ala Thr Gly 
            180                 185                 190         


Phe Gly Thr Asn Glu Thr Glu Tyr Leu Phe Glu Val Asp Asn Leu Thr 
        195                 200                 205             


Tyr Val Gln Leu Glu Ser Arg Phe Thr Pro Gln Phe Leu Leu Gln Leu 
    210                 215                 220                 


Asn Glu Thr Ile Tyr Thr Ser Gly Lys Arg Ser Asn Thr Thr Gly Lys 
225                 230                 235                 240 


Leu Ile Trp Lys Val Asn Pro Glu Ile Asp Thr Thr Ile Gly Glu Trp 
                245                 250                 255     


Ala Phe Trp Glu Thr Lys Lys Asn Leu Thr Arg Lys Ile Arg Ser Glu 
            260                 265                 270         


Glu Leu Ser Phe Thr Val Val Ser Asn Gly Ala Lys Asn Ile Ser Gly 
        275                 280                 285             


Gln Ser Pro Ala Arg Thr Ser Ser Asp Pro Gly Thr Asn Thr Thr Thr 
    290                 295                 300                 


Glu Asp His Lys Ile Met Ala Ser Glu Asn Ser Ser Ala Met Val Gln 
305                 310                 315                 320 


Val His Ser Gln Gly Arg Glu Ala Ala Val Ser His Leu Thr Thr Leu 
                325                 330                 335     


Ala Thr Ile Ser Thr Ser Pro Gln Ser Leu Thr Thr Lys Pro Gly Pro 
            340                 345                 350         


Asp Asn Ser Thr His Asn Thr Pro Val Tyr Lys Leu Asp Ile Ser Glu 
        355                 360                 365             


Ala Thr Gln Val Glu Gln His His Arg Arg Thr Asp Asn Asp Ser Thr 
    370                 375                 380                 


Ala Ser Asp Thr Pro Ser Ala Thr Thr Ala Ala Gly Pro Pro Lys Ala 
385                 390                 395                 400 


Glu Asn Thr Asn Thr Ser Lys Ser Thr Asp Phe Leu Asp Pro Ala Thr 
                405                 410                 415     


Thr Thr Ser Pro Gln Asn His Ser Glu Thr Ala Gly Asn Asn Asn Thr 
            420                 425                 430         


His His Gln Asp Thr Gly Glu Glu Ser Ala Ser Ser Gly Lys Leu Gly 
        435                 440                 445             


Leu Ile Thr Asn Thr Ile Ala Gly Val Ala Gly Leu Ile Thr Gly Gly 
    450                 455                 460                 


Arg Arg Thr Arg Arg Glu Ala Ile Val Asn Ala Gln Pro Lys Cys Asn 
465                 470                 475                 480 


Pro Asn Leu His Tyr Trp Thr Thr Gln Asp Glu Gly Ala Ala Ile Gly 
                485                 490                 495     


Leu Ala Trp Ile Pro Tyr Phe Gly Pro Ala Ala Glu Gly Ile Tyr Ile 
            500                 505                 510         


Glu Gly Leu Met His Asn Gln Asp Gly Leu Ile Cys Gly Leu Arg Gln 
        515                 520                 525             


Leu Ala Asn Glu Thr Thr Gln Ala Leu Gln Leu Phe Leu Arg Ala Thr 
    530                 535                 540                 


Thr Glu Leu Arg Thr Phe Ser Ile Leu Asn Arg Met Ala Ile Asp Phe 
545                 550                 555                 560 


Leu Leu Gln Arg Trp Gly Gly Thr Cys His Ile Leu Gly Pro Asp Cys 
                565                 570                 575     


Cys Ile Glu Pro His Asp Trp Thr Lys Asn Ile Thr Asp Lys Ile Asp 
            580                 585                 590         


Gln Ile Ile His Asp Phe Val Asp Lys Thr Leu Pro Asp Gln Gly Asp 
        595                 600                 605             


Asn Asp Asn Trp Trp Thr Gly 
    610                 615 


<210> 33
<211> 615
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 33
Ile Pro Leu Gly Val Ile His Asn Ser Thr Leu Gln Val Ser Asp Val 
1               5                   10                  15      


Asp Lys Leu Val Cys Arg Asp Lys Leu Ser Ser Thr Asn Gln Leu Arg 
            20                  25                  30          


Ser Val Gly Leu Asn Leu Glu Gly Asn Gly Val Ala Thr Asp Val Pro 
        35                  40                  45              


Ser Ala Thr Lys Arg Trp Gly Phe Arg Ser Gly Val Pro Pro Lys Val 
    50                  55                  60                  


Val Asn Tyr Glu Ala Gly Glu Trp Ala Glu Asn Cys Tyr Asn Leu Glu 
65                  70                  75                  80  


Ile Lys Lys Pro Asp Gly Ser Glu Cys Leu Pro Ala Ala Pro Asp Gly 
                85                  90                  95      


Ile Arg Gly Phe Pro Arg Cys Arg Tyr Val His Lys Val Ser Gly Thr 
            100                 105                 110         


Gly Pro Cys Ala Gly Asp Phe Ala Phe His Lys Glu Gly Ala Phe Phe 
        115                 120                 125             


Leu Tyr Asp Arg Leu Ala Ser Thr Val Ile Tyr Arg Gly Thr Thr Phe 
    130                 135                 140                 


Ala Glu Gly Val Val Ala Phe Leu Ile Leu Pro Gln Ala Lys Lys Asp 
145                 150                 155                 160 


Phe Phe Ser Ser His Pro Leu Arg Glu Pro Val Asn Ala Thr Glu Asp 
                165                 170                 175     


Pro Ser Ser Gly Tyr Tyr Ser Thr Thr Ile Arg Tyr Gln Ala Thr Gly 
            180                 185                 190         


Phe Gly Thr Asn Glu Thr Glu Tyr Leu Phe Glu Val Asp Asn Leu Thr 
        195                 200                 205             


Tyr Val Gln Leu Glu Ser Arg Phe Thr Pro Gln Phe Leu Leu Gln Leu 
    210                 215                 220                 


Asn Glu Thr Ile Tyr Thr Ser Gly Lys Arg Ser Asn Thr Thr Gly Lys 
225                 230                 235                 240 


Leu Ile Trp Lys Val Asn Pro Glu Ile Asp Thr Thr Ile Gly Glu Trp 
                245                 250                 255     


Ala Phe Trp Glu Thr Lys Lys Asn Leu Thr Arg Lys Ile Arg Ser Glu 
            260                 265                 270         


Glu Leu Ser Phe Thr Val Val Ser Asn Gly Ala Lys Asn Ile Ser Gly 
        275                 280                 285             


Gln Ser Pro Ala Arg Thr Ser Ser Asp Pro Gly Thr Asn Thr Thr Thr 
    290                 295                 300                 


Glu Asp His Lys Ile Met Ala Ser Glu Asn Ser Ser Ala Met Val Gln 
305                 310                 315                 320 


Val His Ser Gln Gly Arg Glu Ala Ala Val Ser His Leu Thr Thr Leu 
                325                 330                 335     


Ala Thr Ile Ser Thr Ser Pro Gln Ser Leu Thr Thr Lys Pro Gly Pro 
            340                 345                 350         


Asp Asn Ser Thr His Asn Thr Pro Val Tyr Lys Leu Asp Ile Ser Glu 
        355                 360                 365             


Ala Thr Gln Val Glu Gln His His Arg Arg Thr Asp Asn Asp Ser Thr 
    370                 375                 380                 


Ala Ser Asp Thr Pro Ser Ala Thr Thr Ala Ala Gly Pro Pro Lys Ala 
385                 390                 395                 400 


Glu Asn Thr Asn Thr Ser Lys Ser Thr Asp Phe Leu Asp Pro Ala Thr 
                405                 410                 415     


Thr Thr Ser Pro Gln Asn His Ser Glu Thr Ala Gly Asn Asn Asn Thr 
            420                 425                 430         


His His Gln Asp Thr Gly Glu Glu Ser Ala Ser Ser Gly Lys Leu Gly 
        435                 440                 445             


Leu Ile Thr Asn Thr Ile Ala Gly Val Ala Gly Leu Ile Thr Gly Gly 
    450                 455                 460                 


Arg Arg Thr Arg Arg Glu Ala Ile Val Asn Ala Gln Pro Lys Cys Asn 
465                 470                 475                 480 


Pro Asn Leu His Tyr Trp Thr Thr Gln Asp Glu Gly Ala Ala Ile Gly 
                485                 490                 495     


Leu Ala Trp Ile Pro Tyr Phe Gly Pro Ala Ala Glu Gly Ile Tyr Ile 
            500                 505                 510         


Glu Gly Leu Met His Asn Gln Asp Gly Leu Ile Cys Gly Leu Arg Gln 
        515                 520                 525             


Leu Ala Asn Glu Thr Thr Gln Ala Leu Gln Leu Phe Leu Arg Ala Thr 
    530                 535                 540                 


Thr Glu Leu Arg Thr Phe Ser Ile Leu Asn Arg Tyr Ala Ile Asp Phe 
545                 550                 555                 560 


Leu Leu Gln Arg Trp Gly Gly Thr Cys His Ile Leu Gly Pro Asp Cys 
                565                 570                 575     


Cys Ile Glu Pro His Asp Trp Thr Lys Asn Ile Thr Asp Lys Ile Asp 
            580                 585                 590         


Gln Ile Ile His Asp Phe Val Asp Lys Thr Leu Pro Asp Gln Gly Asp 
        595                 600                 605             


Asn Asp Asn Trp Trp Thr Gly 
    610                 615 


<210> 34
<211> 458
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 34
Ile Pro Leu Gly Val Ile His Asn Ser Thr Leu Gln Val Ser Asp Val 
1               5                   10                  15      


Asp Lys Leu Val Cys Arg Asp Lys Leu Ser Ser Thr Asn Gln Leu Arg 
            20                  25                  30          


Ser Val Gly Leu Asn Leu Glu Gly Asn Gly Val Ala Thr Asp Val Pro 
        35                  40                  45              


Ser Ala Thr Lys Arg Trp Gly Phe Arg Ser Gly Val Pro Pro Lys Val 
    50                  55                  60                  


Val Asn Tyr Glu Ala Gly Glu Trp Ala Glu Asn Cys Tyr Asn Leu Glu 
65                  70                  75                  80  


Ile Lys Lys Pro Asp Gly Ser Glu Cys Leu Pro Ala Ala Pro Asp Gly 
                85                  90                  95      


Ile Arg Gly Phe Pro Arg Cys Arg Tyr Val His Lys Val Ser Gly Thr 
            100                 105                 110         


Gly Pro Cys Ala Gly Asp Phe Ala Phe His Lys Glu Gly Ala Phe Phe 
        115                 120                 125             


Leu Tyr Asp Arg Leu Ala Ser Thr Val Ile Tyr Arg Gly Thr Thr Phe 
    130                 135                 140                 


Ala Glu Gly Val Val Ala Phe Leu Ile Leu Pro Gln Ala Lys Lys Asp 
145                 150                 155                 160 


Phe Phe Ser Ser His Pro Leu Arg Glu Pro Val Asn Ala Thr Glu Asp 
                165                 170                 175     


Pro Ser Ser Gly Tyr Tyr Ser Thr Thr Ile Arg Tyr Gln Ala Thr Gly 
            180                 185                 190         


Phe Gly Thr Asn Glu Thr Glu Tyr Leu Phe Glu Val Asp Asn Leu Thr 
        195                 200                 205             


Tyr Val Gln Leu Glu Ser Arg Phe Thr Pro Gln Phe Leu Leu Gln Leu 
    210                 215                 220                 


Asn Glu Thr Ile Tyr Thr Ser Gly Lys Arg Ser Asn Thr Thr Gly Lys 
225                 230                 235                 240 


Leu Ile Trp Lys Val Asn Pro Glu Ile Asp Thr Thr Ile Gly Glu Trp 
                245                 250                 255     


Ala Phe Trp Glu Thr Lys Lys Asn Leu Thr Arg Lys Ile Arg Ser Glu 
            260                 265                 270         


Glu Leu Ser Phe Thr Val Val Ser Asn Gly Ala Lys Asn Ile Ser Gly 
        275                 280                 285             


Lys Leu Gly Leu Ile Thr Asn Thr Ile Ala Gly Val Ala Gly Leu Ile 
    290                 295                 300                 


Thr Gly Gly Arg Arg Thr Arg Arg Glu Ala Ile Val Asn Ala Gln Pro 
305                 310                 315                 320 


Lys Cys Asn Pro Asn Leu His Tyr Trp Thr Thr Gln Asp Glu Gly Ala 
                325                 330                 335     


Ala Ile Gly Leu Ala Trp Ile Pro Tyr Phe Gly Pro Ala Ala Glu Gly 
            340                 345                 350         


Ile Tyr Ile Glu Gly Leu Met His Asn Gln Asp Gly Leu Ile Cys Gly 
        355                 360                 365             


Leu Arg Gln Leu Ala Asn Glu Thr Thr Gln Ala Leu Gln Leu Phe Leu 
    370                 375                 380                 


Arg Ala Thr Thr Glu Leu Arg Thr Phe Ser Ile Leu Asn Arg Ala Ala 
385                 390                 395                 400 


Ile Asp Phe Leu Leu Gln Arg Trp Gly Gly Thr Cys His Ile Leu Gly 
                405                 410                 415     


Pro Asp Cys Cys Ile Glu Pro His Asp Trp Thr Lys Asn Ile Thr Asp 
            420                 425                 430         


Lys Ile Asp Gln Ile Ile His Asp Phe Val Asp Lys Thr Leu Pro Asp 
        435                 440                 445             


Gln Gly Asp Asn Asp Asn Trp Trp Thr Gly 
    450                 455             


<210> 35
<211> 458
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 35
Ile Pro Leu Gly Val Ile His Asn Ser Thr Leu Gln Val Ser Asp Val 
1               5                   10                  15      


Asp Lys Leu Val Cys Arg Asp Lys Leu Ser Ser Thr Asn Gln Leu Arg 
            20                  25                  30          


Ser Val Gly Leu Asn Leu Glu Gly Asn Gly Val Ala Thr Asp Val Pro 
        35                  40                  45              


Ser Ala Thr Lys Arg Trp Gly Phe Arg Ser Gly Val Pro Pro Lys Val 
    50                  55                  60                  


Val Asn Tyr Glu Ala Gly Glu Trp Ala Glu Asn Cys Tyr Asn Leu Glu 
65                  70                  75                  80  


Ile Lys Lys Pro Asp Gly Ser Glu Cys Leu Pro Ala Ala Pro Asp Gly 
                85                  90                  95      


Ile Arg Gly Phe Pro Arg Cys Arg Tyr Val His Lys Val Ser Gly Thr 
            100                 105                 110         


Gly Pro Cys Ala Gly Asp Phe Ala Phe His Lys Glu Gly Ala Phe Phe 
        115                 120                 125             


Leu Tyr Asp Arg Leu Ala Ser Thr Val Ile Tyr Arg Gly Thr Thr Phe 
    130                 135                 140                 


Ala Glu Gly Val Val Ala Phe Leu Ile Leu Pro Gln Ala Lys Lys Asp 
145                 150                 155                 160 


Phe Phe Ser Ser His Pro Leu Arg Glu Pro Val Asn Ala Thr Glu Asp 
                165                 170                 175     


Pro Ser Ser Gly Tyr Tyr Ser Thr Thr Ile Arg Tyr Gln Ala Thr Gly 
            180                 185                 190         


Phe Gly Thr Asn Glu Thr Glu Tyr Leu Phe Glu Val Asp Asn Leu Thr 
        195                 200                 205             


Tyr Val Gln Leu Glu Ser Arg Phe Thr Pro Gln Phe Leu Leu Gln Leu 
    210                 215                 220                 


Asn Glu Thr Ile Tyr Thr Ser Gly Lys Arg Ser Asn Thr Thr Gly Lys 
225                 230                 235                 240 


Leu Ile Trp Lys Val Asn Pro Glu Ile Asp Thr Thr Ile Gly Glu Trp 
                245                 250                 255     


Ala Phe Trp Glu Thr Lys Lys Asn Leu Thr Arg Lys Ile Arg Ser Glu 
            260                 265                 270         


Glu Leu Ser Phe Thr Val Val Ser Asn Gly Ala Lys Asn Ile Ser Gly 
        275                 280                 285             


Lys Leu Gly Leu Ile Thr Asn Thr Ile Ala Gly Val Ala Gly Leu Ile 
    290                 295                 300                 


Thr Gly Gly Arg Arg Thr Arg Arg Glu Ala Ile Val Asn Ala Gln Pro 
305                 310                 315                 320 


Lys Cys Asn Pro Asn Leu His Tyr Trp Thr Thr Gln Asp Glu Gly Ala 
                325                 330                 335     


Ala Ile Gly Leu Ala Trp Ile Pro Tyr Phe Gly Pro Ala Ala Glu Gly 
            340                 345                 350         


Ile Tyr Ile Glu Gly Leu Met His Asn Gln Asp Gly Leu Ile Cys Gly 
        355                 360                 365             


Leu Arg Gln Leu Ala Asn Glu Thr Thr Gln Ala Leu Gln Leu Phe Leu 
    370                 375                 380                 


Arg Ala Thr Thr Glu Leu Arg Thr Phe Ser Ile Leu Asn Arg Val Ala 
385                 390                 395                 400 


Ile Asp Phe Leu Leu Gln Arg Trp Gly Gly Thr Cys His Ile Leu Gly 
                405                 410                 415     


Pro Asp Cys Cys Ile Glu Pro His Asp Trp Thr Lys Asn Ile Thr Asp 
            420                 425                 430         


Lys Ile Asp Gln Ile Ile His Asp Phe Val Asp Lys Thr Leu Pro Asp 
        435                 440                 445             


Gln Gly Asp Asn Asp Asn Trp Trp Thr Gly 
    450                 455             


<210> 36
<211> 458
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 36
Ile Pro Leu Gly Val Ile His Asn Ser Thr Leu Gln Val Ser Asp Val 
1               5                   10                  15      


Asp Lys Leu Val Cys Arg Asp Lys Leu Ser Ser Thr Asn Gln Leu Arg 
            20                  25                  30          


Ser Val Gly Leu Asn Leu Glu Gly Asn Gly Val Ala Thr Asp Val Pro 
        35                  40                  45              


Ser Ala Thr Lys Arg Trp Gly Phe Arg Ser Gly Val Pro Pro Lys Val 
    50                  55                  60                  


Val Asn Tyr Glu Ala Gly Glu Trp Ala Glu Asn Cys Tyr Asn Leu Glu 
65                  70                  75                  80  


Ile Lys Lys Pro Asp Gly Ser Glu Cys Leu Pro Ala Ala Pro Asp Gly 
                85                  90                  95      


Ile Arg Gly Phe Pro Arg Cys Arg Tyr Val His Lys Val Ser Gly Thr 
            100                 105                 110         


Gly Pro Cys Ala Gly Asp Phe Ala Phe His Lys Glu Gly Ala Phe Phe 
        115                 120                 125             


Leu Tyr Asp Arg Leu Ala Ser Thr Val Ile Tyr Arg Gly Thr Thr Phe 
    130                 135                 140                 


Ala Glu Gly Val Val Ala Phe Leu Ile Leu Pro Gln Ala Lys Lys Asp 
145                 150                 155                 160 


Phe Phe Ser Ser His Pro Leu Arg Glu Pro Val Asn Ala Thr Glu Asp 
                165                 170                 175     


Pro Ser Ser Gly Tyr Tyr Ser Thr Thr Ile Arg Tyr Gln Ala Thr Gly 
            180                 185                 190         


Phe Gly Thr Asn Glu Thr Glu Tyr Leu Phe Glu Val Asp Asn Leu Thr 
        195                 200                 205             


Tyr Val Gln Leu Glu Ser Arg Phe Thr Pro Gln Phe Leu Leu Gln Leu 
    210                 215                 220                 


Asn Glu Thr Ile Tyr Thr Ser Gly Lys Arg Ser Asn Thr Thr Gly Lys 
225                 230                 235                 240 


Leu Ile Trp Lys Val Asn Pro Glu Ile Asp Thr Thr Ile Gly Glu Trp 
                245                 250                 255     


Ala Phe Trp Glu Thr Lys Lys Asn Leu Thr Arg Lys Ile Arg Ser Glu 
            260                 265                 270         


Glu Leu Ser Phe Thr Val Val Ser Asn Gly Ala Lys Asn Ile Ser Gly 
        275                 280                 285             


Lys Leu Gly Leu Ile Thr Asn Thr Ile Ala Gly Val Ala Gly Leu Ile 
    290                 295                 300                 


Thr Gly Gly Arg Arg Thr Arg Arg Glu Ala Ile Val Asn Ala Gln Pro 
305                 310                 315                 320 


Lys Cys Asn Pro Asn Leu His Tyr Trp Thr Thr Gln Asp Glu Gly Ala 
                325                 330                 335     


Ala Ile Gly Leu Ala Trp Ile Pro Tyr Phe Gly Pro Ala Ala Glu Gly 
            340                 345                 350         


Ile Tyr Ile Glu Gly Leu Met His Asn Gln Asp Gly Leu Ile Cys Gly 
        355                 360                 365             


Leu Arg Gln Leu Ala Asn Glu Thr Thr Gln Ala Leu Gln Leu Phe Leu 
    370                 375                 380                 


Arg Ala Thr Thr Glu Leu Arg Thr Phe Ser Ile Leu Asn Arg Ile Ala 
385                 390                 395                 400 


Ile Asp Phe Leu Leu Gln Arg Trp Gly Gly Thr Cys His Ile Leu Gly 
                405                 410                 415     


Pro Asp Cys Cys Ile Glu Pro His Asp Trp Thr Lys Asn Ile Thr Asp 
            420                 425                 430         


Lys Ile Asp Gln Ile Ile His Asp Phe Val Asp Lys Thr Leu Pro Asp 
        435                 440                 445             


Gln Gly Asp Asn Asp Asn Trp Trp Thr Gly 
    450                 455             


<210> 37
<211> 458
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 37
Ile Pro Leu Gly Val Ile His Asn Ser Thr Leu Gln Val Ser Asp Val 
1               5                   10                  15      


Asp Lys Leu Val Cys Arg Asp Lys Leu Ser Ser Thr Asn Gln Leu Arg 
            20                  25                  30          


Ser Val Gly Leu Asn Leu Glu Gly Asn Gly Val Ala Thr Asp Val Pro 
        35                  40                  45              


Ser Ala Thr Lys Arg Trp Gly Phe Arg Ser Gly Val Pro Pro Lys Val 
    50                  55                  60                  


Val Asn Tyr Glu Ala Gly Glu Trp Ala Glu Asn Cys Tyr Asn Leu Glu 
65                  70                  75                  80  


Ile Lys Lys Pro Asp Gly Ser Glu Cys Leu Pro Ala Ala Pro Asp Gly 
                85                  90                  95      


Ile Arg Gly Phe Pro Arg Cys Arg Tyr Val His Lys Val Ser Gly Thr 
            100                 105                 110         


Gly Pro Cys Ala Gly Asp Phe Ala Phe His Lys Glu Gly Ala Phe Phe 
        115                 120                 125             


Leu Tyr Asp Arg Leu Ala Ser Thr Val Ile Tyr Arg Gly Thr Thr Phe 
    130                 135                 140                 


Ala Glu Gly Val Val Ala Phe Leu Ile Leu Pro Gln Ala Lys Lys Asp 
145                 150                 155                 160 


Phe Phe Ser Ser His Pro Leu Arg Glu Pro Val Asn Ala Thr Glu Asp 
                165                 170                 175     


Pro Ser Ser Gly Tyr Tyr Ser Thr Thr Ile Arg Tyr Gln Ala Thr Gly 
            180                 185                 190         


Phe Gly Thr Asn Glu Thr Glu Tyr Leu Phe Glu Val Asp Asn Leu Thr 
        195                 200                 205             


Tyr Val Gln Leu Glu Ser Arg Phe Thr Pro Gln Phe Leu Leu Gln Leu 
    210                 215                 220                 


Asn Glu Thr Ile Tyr Thr Ser Gly Lys Arg Ser Asn Thr Thr Gly Lys 
225                 230                 235                 240 


Leu Ile Trp Lys Val Asn Pro Glu Ile Asp Thr Thr Ile Gly Glu Trp 
                245                 250                 255     


Ala Phe Trp Glu Thr Lys Lys Asn Leu Thr Arg Lys Ile Arg Ser Glu 
            260                 265                 270         


Glu Leu Ser Phe Thr Val Val Ser Asn Gly Ala Lys Asn Ile Ser Gly 
        275                 280                 285             


Lys Leu Gly Leu Ile Thr Asn Thr Ile Ala Gly Val Ala Gly Leu Ile 
    290                 295                 300                 


Thr Gly Gly Arg Arg Thr Arg Arg Glu Ala Ile Val Asn Ala Gln Pro 
305                 310                 315                 320 


Lys Cys Asn Pro Asn Leu His Tyr Trp Thr Thr Gln Asp Glu Gly Ala 
                325                 330                 335     


Ala Ile Gly Leu Ala Trp Ile Pro Tyr Phe Gly Pro Ala Ala Glu Gly 
            340                 345                 350         


Ile Tyr Ile Glu Gly Leu Met His Asn Gln Asp Gly Leu Ile Cys Gly 
        355                 360                 365             


Leu Arg Gln Leu Ala Asn Glu Thr Thr Gln Ala Leu Gln Leu Phe Leu 
    370                 375                 380                 


Arg Ala Thr Thr Glu Leu Arg Thr Phe Ser Ile Leu Asn Arg Leu Ala 
385                 390                 395                 400 


Ile Asp Phe Leu Leu Gln Arg Trp Gly Gly Thr Cys His Ile Leu Gly 
                405                 410                 415     


Pro Asp Cys Cys Ile Glu Pro His Asp Trp Thr Lys Asn Ile Thr Asp 
            420                 425                 430         


Lys Ile Asp Gln Ile Ile His Asp Phe Val Asp Lys Thr Leu Pro Asp 
        435                 440                 445             


Gln Gly Asp Asn Asp Asn Trp Trp Thr Gly 
    450                 455             


<210> 38
<211> 459
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 38
Ile Pro Leu Gly Val Ile His Asn Ser Thr Leu Gln Val Ser Asp Val 
1               5                   10                  15      


Asp Lys Leu Val Cys Arg Asp Lys Leu Ser Ser Thr Asn Gln Leu Arg 
            20                  25                  30          


Ser Val Gly Leu Asn Leu Glu Gly Asn Gly Val Ala Thr Asp Val Pro 
        35                  40                  45              


Ser Ala Thr Lys Arg Trp Gly Phe Arg Ser Gly Val Pro Pro Lys Val 
    50                  55                  60                  


Val Asn Tyr Glu Ala Gly Glu Trp Ala Glu Asn Cys Tyr Asn Leu Glu 
65                  70                  75                  80  


Ile Lys Lys Pro Asp Gly Ser Glu Cys Leu Pro Ala Ala Pro Asp Gly 
                85                  90                  95      


Ile Arg Gly Phe Pro Arg Cys Arg Tyr Val His Lys Val Ser Gly Thr 
            100                 105                 110         


Gly Pro Cys Ala Gly Asp Phe Ala Phe His Lys Glu Gly Ala Phe Phe 
        115                 120                 125             


Leu Tyr Asp Arg Leu Ala Ser Thr Val Ile Tyr Arg Gly Thr Thr Phe 
    130                 135                 140                 


Ala Glu Gly Val Val Ala Phe Leu Ile Leu Pro Gln Ala Lys Lys Asp 
145                 150                 155                 160 


Phe Phe Ser Ser His Pro Leu Arg Glu Pro Val Asn Ala Thr Glu Asp 
                165                 170                 175     


Pro Ser Ser Gly Tyr Tyr Ser Thr Thr Ile Arg Tyr Gln Ala Thr Gly 
            180                 185                 190         


Phe Gly Thr Asn Glu Thr Glu Tyr Leu Phe Glu Val Asp Asn Leu Thr 
        195                 200                 205             


Tyr Val Gln Leu Glu Ser Arg Phe Thr Pro Gln Phe Leu Leu Gln Leu 
    210                 215                 220                 


Asn Glu Thr Ile Tyr Thr Ser Gly Lys Arg Ser Asn Thr Thr Gly Lys 
225                 230                 235                 240 


Leu Ile Trp Lys Val Asn Pro Glu Ile Asp Thr Thr Ile Gly Glu Trp 
                245                 250                 255     


Ala Phe Trp Glu Thr Lys Lys Asn Leu Thr Arg Lys Ile Arg Ser Glu 
            260                 265                 270         


Glu Leu Ser Phe Thr Val Val Ser Asn Gly Ala Lys Asn Ile Ser Gly 
        275                 280                 285             


Lys Leu Gly Leu Ile Thr Asn Thr Ile Ala Gly Val Ala Gly Leu Ile 
    290                 295                 300                 


Thr Gly Gly Arg Arg Thr Arg Arg Glu Ala Ile Val Asn Ala Gln Pro 
305                 310                 315                 320 


Lys Cys Asn Pro Asn Leu His Tyr Trp Thr Thr Gln Asp Glu Gly Ala 
                325                 330                 335     


Ala Ile Gly Leu Ala Trp Ile Pro Tyr Phe Gly Pro Ala Ala Glu Gly 
            340                 345                 350         


Ile Tyr Ile Glu Gly Leu Met His Asn Gln Asp Gly Leu Ile Cys Gly 
        355                 360                 365             


Leu Arg Gln Leu Ala Asn Glu Thr Thr Gln Ala Leu Gln Leu Phe Leu 
    370                 375                 380                 


Arg Ala Thr Thr Glu Leu Arg Thr Phe Ser Ile Leu Asn Arg Met Ala 
385                 390                 395                 400 


Ile Asp Phe Leu Leu Gln Arg Trp Gly Gly Thr Cys His Ile Leu Gly 
                405                 410                 415     


Pro Asp Cys Cys Ile Glu Pro His Asp Trp Thr Lys Asn Ile Thr Asp 
            420                 425                 430         


Lys Ile Asp Gln Ile Ile His Asp Phe Val Asp Lys Thr Leu Pro Asp 
        435                 440                 445             


Gln Gly Asp Asn Asp Asn Trp Trp Thr Gly His 
    450                 455                 


<210> 39
<211> 458
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 39
Ile Pro Leu Gly Val Ile His Asn Ser Thr Leu Gln Val Ser Asp Val 
1               5                   10                  15      


Asp Lys Leu Val Cys Arg Asp Lys Leu Ser Ser Thr Asn Gln Leu Arg 
            20                  25                  30          


Ser Val Gly Leu Asn Leu Glu Gly Asn Gly Val Ala Thr Asp Val Pro 
        35                  40                  45              


Ser Ala Thr Lys Arg Trp Gly Phe Arg Ser Gly Val Pro Pro Lys Val 
    50                  55                  60                  


Val Asn Tyr Glu Ala Gly Glu Trp Ala Glu Asn Cys Tyr Asn Leu Glu 
65                  70                  75                  80  


Ile Lys Lys Pro Asp Gly Ser Glu Cys Leu Pro Ala Ala Pro Asp Gly 
                85                  90                  95      


Ile Arg Gly Phe Pro Arg Cys Arg Tyr Val His Lys Val Ser Gly Thr 
            100                 105                 110         


Gly Pro Cys Ala Gly Asp Phe Ala Phe His Lys Glu Gly Ala Phe Phe 
        115                 120                 125             


Leu Tyr Asp Arg Leu Ala Ser Thr Val Ile Tyr Arg Gly Thr Thr Phe 
    130                 135                 140                 


Ala Glu Gly Val Val Ala Phe Leu Ile Leu Pro Gln Ala Lys Lys Asp 
145                 150                 155                 160 


Phe Phe Ser Ser His Pro Leu Arg Glu Pro Val Asn Ala Thr Glu Asp 
                165                 170                 175     


Pro Ser Ser Gly Tyr Tyr Ser Thr Thr Ile Arg Tyr Gln Ala Thr Gly 
            180                 185                 190         


Phe Gly Thr Asn Glu Thr Glu Tyr Leu Phe Glu Val Asp Asn Leu Thr 
        195                 200                 205             


Tyr Val Gln Leu Glu Ser Arg Phe Thr Pro Gln Phe Leu Leu Gln Leu 
    210                 215                 220                 


Asn Glu Thr Ile Tyr Thr Ser Gly Lys Arg Ser Asn Thr Thr Gly Lys 
225                 230                 235                 240 


Leu Ile Trp Lys Val Asn Pro Glu Ile Asp Thr Thr Ile Gly Glu Trp 
                245                 250                 255     


Ala Phe Trp Glu Thr Lys Lys Asn Leu Thr Arg Lys Ile Arg Ser Glu 
            260                 265                 270         


Glu Leu Ser Phe Thr Val Val Ser Asn Gly Ala Lys Asn Ile Ser Gly 
        275                 280                 285             


Lys Leu Gly Leu Ile Thr Asn Thr Ile Ala Gly Val Ala Gly Leu Ile 
    290                 295                 300                 


Thr Gly Gly Arg Arg Thr Arg Arg Glu Ala Ile Val Asn Ala Gln Pro 
305                 310                 315                 320 


Lys Cys Asn Pro Asn Leu His Tyr Trp Thr Thr Gln Asp Glu Gly Ala 
                325                 330                 335     


Ala Ile Gly Leu Ala Trp Ile Pro Tyr Phe Gly Pro Ala Ala Glu Gly 
            340                 345                 350         


Ile Tyr Ile Glu Gly Leu Met His Asn Gln Asp Gly Leu Ile Cys Gly 
        355                 360                 365             


Leu Arg Gln Leu Ala Asn Glu Thr Thr Gln Ala Leu Gln Leu Phe Leu 
    370                 375                 380                 


Arg Ala Thr Thr Glu Leu Arg Thr Phe Ser Ile Leu Asn Arg Tyr Ala 
385                 390                 395                 400 


Ile Asp Phe Leu Leu Gln Arg Trp Gly Gly Thr Cys His Ile Leu Gly 
                405                 410                 415     


Pro Asp Cys Cys Ile Glu Pro His Asp Trp Thr Lys Asn Ile Thr Asp 
            420                 425                 430         


Lys Ile Asp Gln Ile Ile His Asp Phe Val Asp Lys Thr Leu Pro Asp 
        435                 440                 445             


Gln Gly Asp Asn Asp Asn Trp Trp Thr Gly 
    450                 455             


<210> 40
<211> 458
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 40
Ile Pro Leu Gly Val Ile His Asn Ser Thr Leu Gln Val Ser Asp Val 
1               5                   10                  15      


Asp Lys Leu Val Cys Arg Asp Lys Leu Ser Ser Thr Asn Gln Leu Arg 
            20                  25                  30          


Ser Val Gly Leu Asn Leu Glu Gly Asn Gly Val Ala Thr Asp Val Pro 
        35                  40                  45              


Ser Ala Thr Lys Arg Trp Gly Phe Arg Ser Gly Val Pro Pro Lys Val 
    50                  55                  60                  


Val Asn Tyr Glu Ala Gly Glu Trp Ala Glu Asn Cys Tyr Asn Leu Glu 
65                  70                  75                  80  


Ile Lys Lys Pro Asp Gly Ser Glu Cys Leu Pro Ala Ala Pro Asp Gly 
                85                  90                  95      


Ile Arg Gly Phe Pro Arg Cys Arg Tyr Val His Lys Val Ser Gly Thr 
            100                 105                 110         


Gly Pro Cys Ala Gly Asp Phe Ala Phe His Lys Glu Gly Ala Phe Phe 
        115                 120                 125             


Leu Tyr Asp Arg Leu Ala Ser Thr Val Ile Tyr Arg Gly Thr Thr Phe 
    130                 135                 140                 


Ala Glu Gly Val Val Ala Phe Leu Ile Leu Pro Gln Ala Lys Lys Asp 
145                 150                 155                 160 


Phe Phe Ser Ser His Pro Leu Arg Glu Pro Val Asn Ala Thr Glu Asp 
                165                 170                 175     


Pro Ser Ser Gly Tyr Tyr Ser Thr Thr Ile Arg Tyr Gln Ala Thr Gly 
            180                 185                 190         


Phe Gly Thr Asn Glu Thr Glu Tyr Leu Phe Glu Val Asp Asn Leu Thr 
        195                 200                 205             


Tyr Val Gln Leu Glu Ser Arg Phe Thr Pro Gln Phe Leu Leu Gln Leu 
    210                 215                 220                 


Asn Glu Thr Ile Tyr Thr Ser Gly Lys Arg Ser Asn Thr Thr Gly Lys 
225                 230                 235                 240 


Leu Ile Trp Lys Val Asn Pro Glu Ile Asp Thr Thr Ile Gly Glu Trp 
                245                 250                 255     


Ala Phe Trp Glu Thr Lys Lys Asn Leu Thr Arg Lys Ile Arg Ser Glu 
            260                 265                 270         


Glu Leu Ser Phe Thr Val Val Ser Asn Gly Ala Lys Asn Ile Ser Gly 
        275                 280                 285             


Lys Leu Gly Leu Ile Thr Asn Thr Ile Ala Gly Val Ala Gly Leu Ile 
    290                 295                 300                 


Thr Gly Gly Arg Arg Thr Arg Arg Glu Ala Ile Val Asn Ala Gln Pro 
305                 310                 315                 320 


Lys Cys Asn Pro Asn Leu His Tyr Trp Thr Thr Gln Asp Glu Gly Ala 
                325                 330                 335     


Ala Ile Gly Leu Ala Trp Ile Pro Tyr Phe Gly Pro Ala Ala Glu Gly 
            340                 345                 350         


Ile Tyr Ile Glu Gly Leu Met His Asn Gln Asp Gly Leu Ile Cys Gly 
        355                 360                 365             


Leu Arg Gln Leu Ala Asn Glu Thr Thr Gln Ala Leu Gln Leu Phe Leu 
    370                 375                 380                 


Arg Ala Thr Thr Glu Leu Arg Thr Phe Ser Ile Leu Asn Arg Trp Ala 
385                 390                 395                 400 


Ile Asp Phe Leu Leu Gln Arg Trp Gly Gly Thr Cys His Ile Leu Gly 
                405                 410                 415     


Pro Asp Cys Cys Ile Glu Pro His Asp Trp Thr Lys Asn Ile Thr Asp 
            420                 425                 430         


Lys Ile Asp Gln Ile Ile His Asp Phe Val Asp Lys Thr Leu Pro Asp 
        435                 440                 445             


Gln Gly Asp Asn Asp Asn Trp Trp Thr Gly 
    450                 455             


<210> 41
<211> 450
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 41
Leu Pro Val Leu Glu Ile Ala Ser Asn Ser Gln Pro Gln Asp Val Asp 
1               5                   10                  15      


Ser Val Cys Ser Gly Thr Leu Gln Lys Thr Glu Asp Val His Leu Met 
            20                  25                  30          


Gly Phe Thr Leu Ser Gly Gln Lys Val Ala Asp Ser Pro Leu Glu Ala 
        35                  40                  45              


Ser Lys Arg Trp Ala Phe Arg Thr Gly Val Pro Pro Lys Asn Val Glu 
    50                  55                  60                  


Tyr Thr Glu Gly Glu Glu Ala Lys Thr Cys Tyr Asn Ile Ser Val Thr 
65                  70                  75                  80  


Asp Pro Ser Gly Lys Ser Leu Leu Leu Asp Pro Pro Ser Asn Ile Arg 
                85                  90                  95      


Asp Tyr Pro Lys Cys Lys Thr Val His His Ile Gln Gly Gln Asn Pro 
            100                 105                 110         


His Ala Gln Gly Ile Ala Leu His Leu Trp Gly Ala Phe Phe Leu Tyr 
        115                 120                 125             


Asp Arg Val Ala Ser Thr Thr Met Tyr Arg Gly Lys Val Phe Thr Glu 
    130                 135                 140                 


Gly Asn Ile Ala Ala Met Ile Val Asn Lys Thr Val His Arg Met Ile 
145                 150                 155                 160 


Phe Ser Arg Gln Gly Gln Gly Tyr Arg His Met Asn Leu Thr Ser Thr 
                165                 170                 175     


Asn Lys Tyr Trp Thr Ser Ser Asn Glu Thr Gln Arg Asn Asp Thr Gly 
            180                 185                 190         


Cys Phe Gly Ile Leu Gln Glu Tyr Asn Ser Thr Asn Asn Gln Thr Cys 
        195                 200                 205             


Pro Pro Ser Leu Lys Pro Pro Ser Leu Pro Thr Val Thr Pro Ser Ile 
    210                 215                 220                 


His Ser Thr Asn Thr Gln Ile Asn Thr Ala Lys Ser Gly Thr Arg Pro 
225                 230                 235                 240 


Pro Ile Tyr Phe Arg Lys Lys Arg Ser Ile Leu Ala Lys Glu Gly Asp 
                245                 250                 255     


Ile Gly Pro Asn Leu Asp Gly Leu Ile Asn Thr Glu Ile Asp Phe Asp 
            260                 265                 270         


Pro Ile Pro Asn Thr Glu Thr Ile Phe Asp Glu Ser Pro Ser Phe Asn 
        275                 280                 285             


Thr Ser Thr Asn Glu Glu Gln His Thr Pro Pro Asn Ile Ser Leu Thr 
    290                 295                 300                 


Phe Ser Tyr Phe Pro Asp Lys Asn Gly Asp Thr Ala Tyr Ser Gly Glu 
305                 310                 315                 320 


Asn Glu Asn Asp Cys Asp Ala Glu Leu Arg Ile Trp Ser Val Gln Glu 
                325                 330                 335     


Asp Asp Leu Ala Ala Gly Leu Ser Trp Ile Pro Phe Phe Gly Pro Gly 
            340                 345                 350         


Ile Glu Gly Leu Tyr Thr Ala Gly Leu Ile Lys Asn Gln Asn Asn Leu 
        355                 360                 365             


Val Cys Arg Leu Arg Arg Leu Ala Asn Gln Thr Ala Lys Ser Leu Glu 
    370                 375                 380                 


Leu Leu Leu Arg Val Thr Thr Glu Glu Arg Thr Phe Ser Leu Ile Asn 
385                 390                 395                 400 


Arg Phe Ala Ile Asp Phe Leu Leu Thr Arg Trp Gly Gly Thr Cys Lys 
                405                 410                 415     


Val Leu Gly Pro Asp Cys Cys Ile Gly Ile Glu Asp Leu Ser Lys Asn 
            420                 425                 430         


Ile Ser Glu Gln Ile Asp Lys Ile Arg Lys Asp Glu Gln Lys Glu Glu 
        435                 440                 445             


Thr Gly 
    450 


<210> 42
<211> 450
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 42
Leu Pro Val Leu Glu Ile Ala Ser Asn Ser Gln Pro Gln Asp Val Asp 
1               5                   10                  15      


Ser Val Cys Ser Gly Thr Leu Gln Lys Thr Glu Asp Val His Leu Met 
            20                  25                  30          


Gly Phe Thr Leu Ser Gly Gln Lys Val Ala Asp Ser Pro Leu Glu Ala 
        35                  40                  45              


Ser Lys Arg Trp Ala Phe Arg Thr Gly Val Pro Pro Lys Asn Val Glu 
    50                  55                  60                  


Tyr Thr Glu Gly Glu Glu Ala Lys Thr Cys Tyr Asn Ile Ser Val Thr 
65                  70                  75                  80  


Asp Pro Ser Gly Lys Ser Leu Leu Leu Asp Pro Pro Ser Asn Ile Arg 
                85                  90                  95      


Asp Tyr Pro Lys Cys Lys Thr Val His His Ile Gln Gly Gln Asn Pro 
            100                 105                 110         


His Ala Gln Gly Ile Ala Leu His Leu Trp Gly Ala Phe Phe Leu Tyr 
        115                 120                 125             


Asp Arg Val Ala Ser Thr Thr Met Tyr Arg Gly Lys Val Phe Thr Glu 
    130                 135                 140                 


Gly Asn Ile Ala Ala Met Ile Val Asn Lys Thr Val His Arg Met Ile 
145                 150                 155                 160 


Phe Ser Arg Gln Gly Gln Gly Tyr Arg His Met Asn Leu Thr Ser Thr 
                165                 170                 175     


Asn Lys Tyr Trp Thr Ser Ser Asn Glu Thr Gln Arg Asn Asp Thr Gly 
            180                 185                 190         


Cys Phe Gly Ile Leu Gln Glu Tyr Asn Ser Thr Asn Asn Gln Thr Cys 
        195                 200                 205             


Pro Pro Ser Leu Lys Pro Pro Ser Leu Pro Thr Val Thr Pro Ser Ile 
    210                 215                 220                 


His Ser Thr Asn Thr Gln Ile Asn Thr Ala Lys Ser Gly Thr Arg Pro 
225                 230                 235                 240 


Pro Ile Tyr Phe Arg Lys Lys Arg Ser Ile Leu Ala Lys Glu Gly Asp 
                245                 250                 255     


Ile Gly Pro Asn Leu Asp Gly Leu Ile Asn Thr Glu Ile Asp Phe Asp 
            260                 265                 270         


Pro Ile Pro Asn Thr Glu Thr Ile Phe Asp Glu Ser Pro Ser Phe Asn 
        275                 280                 285             


Thr Ser Thr Asn Glu Glu Gln His Thr Pro Pro Asn Ile Ser Leu Thr 
    290                 295                 300                 


Phe Ser Tyr Phe Pro Asp Lys Asn Gly Asp Thr Ala Tyr Ser Gly Glu 
305                 310                 315                 320 


Asn Glu Asn Asp Cys Asp Ala Glu Leu Arg Ile Trp Ser Val Gln Glu 
                325                 330                 335     


Asp Asp Leu Ala Ala Gly Leu Ser Trp Ile Pro Phe Phe Gly Pro Gly 
            340                 345                 350         


Ile Glu Gly Leu Tyr Thr Ala Gly Leu Ile Lys Asn Gln Asn Asn Leu 
        355                 360                 365             


Val Cys Arg Leu Arg Arg Leu Ala Asn Gln Thr Ala Lys Ser Leu Glu 
    370                 375                 380                 


Leu Leu Leu Arg Val Thr Thr Glu Glu Arg Thr Phe Ser Leu Ile Asn 
385                 390                 395                 400 


Arg Ile Ala Ile Asp Phe Leu Leu Thr Arg Trp Gly Gly Thr Cys Lys 
                405                 410                 415     


Val Leu Gly Pro Asp Cys Cys Ile Gly Ile Glu Asp Leu Ser Lys Asn 
            420                 425                 430         


Ile Ser Glu Gln Ile Asp Lys Ile Arg Lys Asp Glu Gln Lys Glu Glu 
        435                 440                 445             


Thr Gly 
    450 


<210> 43
<211> 637
<212> PRT
<213> Marburg marburgvirus

<400> 43
Met Lys Thr Ile Tyr Phe Leu Ile Ser Leu Ile Leu Ile Gln Ser Ile 
1               5                   10                  15      


Lys Thr Leu Pro Val Leu Glu Ile Ala Ser Asn Ser Gln Pro Gln Asp 
            20                  25                  30          


Val Asp Ser Val Cys Ser Gly Thr Leu Gln Lys Thr Glu Asp Val His 
        35                  40                  45              


Leu Met Gly Phe Thr Leu Ser Gly Gln Lys Val Ala Asp Ser Pro Leu 
    50                  55                  60                  


Glu Ala Ser Lys Arg Trp Ala Phe Arg Thr Gly Val Pro Pro Lys Asn 
65                  70                  75                  80  


Val Glu Tyr Thr Glu Gly Glu Glu Ala Lys Thr Cys Tyr Asn Ile Ser 
                85                  90                  95      


Val Thr Asp Pro Ser Gly Lys Ser Leu Leu Leu Asp Pro Pro Ser Asn 
            100                 105                 110         


Ile Arg Asp Tyr Pro Lys Cys Lys Thr Val His His Ile Gln Gly Gln 
        115                 120                 125             


Asn Pro His Ala Gln Gly Ile Ala Leu His Leu Trp Gly Ala Phe Phe 
    130                 135                 140                 


Leu Tyr Asp Arg Val Ala Ser Thr Thr Met Tyr Arg Gly Lys Val Phe 
145                 150                 155                 160 


Thr Glu Gly Asn Ile Ala Ala Met Ile Val Asn Lys Thr Val His Arg 
                165                 170                 175     


Met Ile Phe Ser Arg Gln Gly Gln Gly Tyr Arg His Met Asn Leu Thr 
            180                 185                 190         


Ser Thr Asn Lys Tyr Trp Thr Ser Ser Asn Glu Thr Arg Arg Asn Asp 
        195                 200                 205             


Thr Gly Cys Phe Gly Ile Leu Gln Glu Tyr Asn Ser Thr Asn Asn Gln 
    210                 215                 220                 


Thr Cys Ser Pro Ser Leu Lys Pro Pro Ser Leu Pro Thr Val Thr Pro 
225                 230                 235                 240 


Ser Ile His Ser Thr Asn Thr Gln Ile Asn Thr Ala Lys Ser Gly Thr 
                245                 250                 255     


Ile Asn Pro Ser Ser Asp Asp Glu Asp Leu Met Val Ser Gly Ser Gly 
            260                 265                 270         


Ser Gly Glu Gln Gly Pro His Thr Thr Leu Asn Val Val Thr Glu Gln 
        275                 280                 285             


Lys Gln Ser Ser Thr Ile Leu Ser Thr Pro Ser Leu His Pro Ser Thr 
    290                 295                 300                 


Pro Gln His Glu Gln Asn Ser Thr Asn Pro Ser Arg His Ala Val Thr 
305                 310                 315                 320 


Glu His Asn Gly Thr Asp Pro Thr Thr Gln Pro Ala Thr Leu Leu Asn 
                325                 330                 335     


Asn Thr Asn Thr Thr Pro Thr Tyr Asn Thr Leu Lys Tyr Asn Leu Ser 
            340                 345                 350         


Thr Pro Ser Pro Pro Thr Arg Asn Ile Thr Asn Asn Asp Thr Gln Arg 
        355                 360                 365             


Glu Leu Ala Glu Ser Glu Gln Thr Asn Ala Gln Leu Asn Thr Thr Pro 
    370                 375                 380                 


Asp Pro Thr Glu Asn Pro Thr Thr Ala Gln Asp Thr Asn Ser Thr Thr 
385                 390                 395                 400 


Asn Ile Thr Met Thr Thr Ser Asp Ile Thr Ser Lys His Pro Thr Asn 
                405                 410                 415     


Ser Ser Pro Asp Ser Ser Pro Thr Thr Arg Pro Pro Ile Tyr Phe Arg 
            420                 425                 430         


Lys Lys Arg Ser Ile Phe Trp Lys Glu Gly Asp Ile Phe Pro Phe Leu 
        435                 440                 445             


Asp Gly Leu Ile Asn Thr Glu Ile Asp Phe Asp Pro Ile Pro Asn Thr 
    450                 455                 460                 


Glu Thr Ile Phe Asp Glu Ser Pro Ser Phe Asn Thr Ser Thr Asn Glu 
465                 470                 475                 480 


Glu Gln His Thr Pro Pro Asn Ile Ser Leu Thr Phe Ser Tyr Phe Pro 
                485                 490                 495     


Asp Lys Asn Gly Asp Thr Ala Tyr Ser Gly Glu Asn Glu Asn Asp Cys 
            500                 505                 510         


Asp Ala Glu Leu Arg Ile Trp Ser Val Gln Glu Asp Asp Leu Ala Ala 
        515                 520                 525             


Gly Leu Ser Trp Ile Pro Phe Phe Gly Pro Gly Ile Glu Gly Leu Tyr 
    530                 535                 540                 


Thr Ala Gly Leu Ile Lys Asn Gln Asn Asn Leu Val Cys Arg Leu Arg 
545                 550                 555                 560 


Arg Leu Ala Asn Gln Thr Ala Lys Ser Leu Glu Leu Leu Leu Arg Val 
                565                 570                 575     


Thr Thr Glu Glu Arg Thr Phe Ser Leu Ile Asn Arg His Ala Ile Asp 
            580                 585                 590         


Phe Leu Leu Thr Arg Trp Gly Gly Thr Cys Lys Val Leu Gly Pro Asp 
        595                 600                 605             


Cys Cys Ile Gly Ile Glu Asp Leu Ser Lys Asn Ile Ser Glu Gln Ile 
    610                 615                 620                 


Asp Lys Ile Arg Lys Asp Glu Gln Lys Glu Glu Thr Gly 
625                 630                 635         


<210> 44
<211> 32
<212> PRT
<213> Zaire ebolavirus

<400> 44
Met Gly Val Thr Gly Ile Leu Gln Leu Pro Arg Asp Arg Phe Lys Arg 
1               5                   10                  15      


Thr Ser Phe Phe Leu Trp Val Ile Ile Leu Phe Gln Arg Thr Phe Ser 
            20                  25                  30          


<210> 45
<211> 18
<212> PRT
<213> Marburg marburgvirus

<400> 45
Met Lys Thr Ile Tyr Phe Leu Ile Ser Leu Ile Leu Ile Gln Ser Ile 
1               5                   10                  15      


Lys Thr 
        


<210> 46
<211> 6
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      6xHis tag"

<400> 46
His His His His His His 
1               5       


