                         SEQUENCE LISTING

<110>  Evercyte GmbH
 
<120>  TARGET-SPECIFIC EXTRACELLULAR VESICLES

<130>  AC015P

<160>  263   

<170>  PatentIn version 3.5

<210>  1
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Binding Sequence

<400>  1

Arg Arg Pro Arg Lys Arg Thr Arg Ser 
1               5                   


<210>  2
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Binding Sequence

<400>  2

Arg Arg Ser Arg Arg Arg Val His Asp 
1               5                   


<210>  3
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Binding Sequence

<400>  3

Ile Trp Arg Ala Arg Arg Arg Arg Ser 
1               5                   


<210>  4
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Binding Sequence

<400>  4

Arg Arg Phe Arg Lys Arg Pro Gly Asp 
1               5                   


<210>  5
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Binding Sequence

<400>  5

Ser Arg Arg Trp Arg His Arg Ile Ala 
1               5                   


<210>  6
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Binding Sequence

<400>  6

Trp Trp Gly Arg Arg Phe Arg Val Ser 
1               5                   


<210>  7
<211>  89
<212>  PRT
<213>  Homo sapiens

<400>  7

Phe Val Asn Lys Asp Gln Ile Ala Lys Asp Val Lys Gln Phe Tyr Asp 
1               5                   10                  15      


Gln Ala Leu Gln Gln Ala Val Val Asp Asp Asp Ala Asn Asn Ala Lys 
            20                  25                  30          


Ala Val Val Lys Thr Phe His Glu Thr Leu Asp Cys Cys Gly Ser Ser 
        35                  40                  45              


Thr Leu Thr Ala Leu Thr Thr Ser Val Leu Lys Asn Asn Leu Cys Pro 
    50                  55                  60                  


Ser Gly Ser Asn Ile Ile Ser Asn Leu Phe Lys Glu Asp Cys His Gln 
65                  70                  75                  80  


Lys Ile Asp Asp Leu Phe Ser Gly Lys 
                85                  


<210>  8
<211>  267
<212>  DNA
<213>  Homo sapiens

<400>  8
tttgtcaaca aggaccagat cgccaaggat gtgaagcagt tctatgacca ggccctacag       60

caggccgtgg tggatgatga cgccaacaac gccaaggctg tggtgaagac cttccacgag      120

acgcttgact gctgtggctc cagcacactg actgctttga ccacctcagt gctcaagaac      180

aatttgtgtc cctcgggcag caacatcatc agcaacctct tcaaggagga ctgccaccag      240

aagatcgatg acctcttctc cgggaag                                          267


<210>  9
<211>  31
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  9
acgtggatcc tttgtcaaca aggaccagat c                                      31


<210>  10
<211>  32
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  10
acgtgcggcc gcgccttccc ggagaagagg tc                                     32


<210>  11
<211>  33
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  11
acgagtgcac agtttgtcaa caaggaccag atc                                    33


<210>  12
<211>  30
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  12
acgtgcggcc gccttcccgg agaagaggtc                                        30


<210>  13
<211>  31
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  13
acgtgctagc tttgtcaaca aggaccagat c                                      31


<210>  14
<211>  34
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  14
acgtggatcc tcatcacttc ccggagaaga ggtc                                   34


<210>  15
<211>  57
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Oligonucleotide


<220>
<221>  misc_feature
<222>  (32)..(33)
<223>  n is any of A, C, G or T

<220>
<221>  misc_feature
<222>  (35)..(36)
<223>  n is any of A, C, G or T

<220>
<221>  misc_feature
<222>  (38)..(39)
<223>  n is any of A, C, G or T

<400>  15
cttccacgag acgcttgact gctgtggatc cnnknnknnk actgctttga ccacctc          57


<210>  16
<211>  86
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Oligonucleotide


<220>
<221>  misc_feature
<222>  (45)..(46)
<223>  n is any one of A or C

<220>
<221>  misc_feature
<222>  (47)..(48)
<223>  n is any one of A, C, G or T

<220>
<221>  misc_feature
<222>  (49)..(49)
<223>  n is any one of A or C

<220>
<221>  misc_feature
<222>  (50)..(51)
<223>  n is any one of A, C, G or T

<220>
<221>  misc_feature
<222>  (52)..(52)
<223>  n is any one of A or C

<220>
<221>  misc_feature
<222>  (53)..(54)
<223>  n is any one of A, C, G or T

<220>
<221>  misc_feature
<222>  (55)..(55)
<223>  n is any one of A or C

<220>
<221>  misc_feature
<222>  (56)..(57)
<223>  n is any one of A, C, G or T

<220>
<221>  misc_feature
<222>  (58)..(58)
<223>  n is any one of A or C

<220>
<221>  misc_feature
<222>  (59)..(60)
<223>  n is any one of A, C, G or T

<220>
<221>  misc_feature
<222>  (61)..(61)
<223>  n is any one of A or C

<220>
<221>  misc_feature
<222>  (62)..(63)
<223>  n is any one of A, C, G or T

<220>
<221>  misc_feature
<222>  (64)..(64)
<223>  n is any one of A or C

<220>
<221>  misc_feature
<222>  (65)..(66)
<223>  n is any one of A, C, G or T

<220>
<221>  misc_feature
<222>  (67)..(67)
<223>  n is any one of A or C

<220>
<221>  misc_feature
<222>  (68)..(69)
<223>  n is any one of A, C, G or T

<400>  16
ccgcgccttc ccggagaaga ggtcatcgat cttctggtgg caaknnnnnn nnnnnnnnnn       60

nnnnnnnnng ttgctgcccg agggac                                            86


<210>  17
<211>  32
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Oligonucleotide

<400>  17
gcttgactgc tgtggatcca gcacactgac tg                                     32


<210>  18
<211>  32
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Oligonucleotide

<400>  18
cagtcagtgt gctggatcca cagcagtcaa gc                                     32


<210>  19
<211>  31
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Oligonucleotide

<400>  19
cgataaggta ccaggttcct ttgtcaacaa g                                      31


<210>  20
<211>  31
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Oligonucleotide

<400>  20
cttgttgaca aaggaacctg gtaccttatc g                                      31


<210>  21
<211>  31
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Oligonucleotide

<400>  21
cgataaggta ccaggttcct ttgtcaacaa g                                      31


<210>  22
<211>  31
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Oligonucleotide

<400>  22
cttgttgaca aaggaacctg gtaccttatc g                                      31


<210>  23
<211>  32
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Oligonucleotide

<400>  23
gtatgttttt aagctcctgc aggctagtgg tg                                     32


<210>  24
<211>  32
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Oligonucleotide

<400>  24
caccactagc ctgcaggagc ttaaaaacat ac                                     32


<210>  25
<211>  33
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Oligonucleotide

<400>  25
tttgtgtccc tcgggatcca acatcatcag caa                                    33


<210>  26
<211>  33
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Oligonucleotide

<400>  26
ttgctgatga tgttggatcc cgagggacac aaa                                    33


<210>  27
<211>  35
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Oligonucleotide

<400>  27
gcagttctat gaccaagctt tacagcaggc cgtgg                                  35


<210>  28
<211>  35
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Oligonucleotide

<400>  28
ccacggcctg ctgtaaagct tggtcataga actgc                                  35


<210>  29
<211>  35
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Oligonucleotide

<400>  29
gcagttctat gaccaagctt tacagcagtg ctgtg                                  35


<210>  30
<211>  35
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Oligonucleotide

<400>  30
cacagcactg ctgtaaagct tggtcataga actgc                                  35


<210>  31
<211>  33
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Oligonucleotide

<400>  31
tttgtgtccc tcgggatcca acatcatcag caa                                    33


<210>  32
<211>  33
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Oligonucleotide

<400>  32
ttgctgatga tgttggatcc cgagggacac aaa                                    33


<210>  33
<211>  78
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Oligonucleotide


<220>
<221>  misc_feature
<222>  (34)..(35)
<223>  n is any one of A, C, G or T

<220>
<221>  misc_feature
<222>  (37)..(38)
<223>  n is any one of A, C, G or T

<220>
<221>  misc_feature
<222>  (46)..(47)
<223>  n is any one of A, C, G or T

<220>
<221>  misc_feature
<222>  (49)..(50)
<223>  n is any one of A, C, G or T

<220>
<221>  misc_feature
<222>  (52)..(53)
<223>  n is any one of A, C, G or T

<220>
<221>  misc_feature
<222>  (55)..(56)
<223>  n is any one of A, C, G or T

<400>  33
aaggatgtga agcagttcta tgaccaagct ttannknnkt gctgtnnknn knnknnkgcc       60

aacaacgcct gtgctgtg                                                     78


<210>  34
<211>  96
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Oligonucleotide


<220>
<221>  misc_feature
<222>  (46)..(46)
<223>  n is any one of A or C

<220>
<221>  misc_feature
<222>  (47)..(48)
<223>  n is any one of A, C, G or T

<220>
<221>  misc_feature
<222>  (49)..(49)
<223>  n is any one of A or C

<220>
<221>  misc_feature
<222>  (50)..(51)
<223>  n is any one of A, C, G or T

<220>
<221>  misc_feature
<222>  (61)..(61)
<223>  n is any one of A or C

<220>
<221>  misc_feature
<222>  (62)..(63)
<223>  n is any one of A, C, G or T

<220>
<221>  misc_feature
<222>  (67)..(67)
<223>  n is any one of A or C

<220>
<221>  misc_feature
<222>  (68)..(69)
<223>  n is any one of A, C, G or T

<220>
<221>  misc_feature
<222>  (70)..(70)
<223>  n is any one of A or C

<220>
<221>  misc_feature
<222>  (71)..(72)
<223>  n is any one of A, C, G or T

<220>
<221>  misc_feature
<222>  (73)..(73)
<223>  n is any one of A or C

<220>
<221>  misc_feature
<222>  (74)..(75)
<223>  n is any one of A, C, G or T

<220>
<221>  misc_feature
<222>  (76)..(76)
<223>  n is any one of A or C

<220>
<221>  misc_feature
<222>  (77)..(78)
<223>  n is any one of A, C, G or T

<400>  34
cttgaagagg ttgctgatga tgttggatcc cgagggacac aaattnnnnn ngagcacaca       60

nnnggtnnnn nnnnnnnntg tgctggagcc acagca                                 96


<210>  35
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Binding Sequence

<400>  35

Gly Ala Ser Ala 
1               


<210>  36
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Binding Sequence

<400>  36

Asp Ala Gly Pro 
1               


<210>  37
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Binding Sequence

<400>  37

Ser Phe Leu Val 
1               


<210>  38
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Binding Sequence

<400>  38

Pro Leu Thr Met 
1               


<210>  39
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Binding Sequence

<400>  39

Ala Lys Met Tyr 
1               


<210>  40
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Binding Sequence

<400>  40

Ser Ala Arg Phe 
1               


<210>  41
<211>  31
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Oligonucleotide

<400>  41
acgtgctagc tttgtcaaca aggaccagat c                                      31


<210>  42
<211>  41
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Oligonucleotide

<400>  42
acgtggtgac cggtgctgga acccttcccg gagaagaggt c                           41


<210>  43
<211>  33
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Oligonucleotide

<400>  43
caggccctac agcagtgcgt ggtggatgat gac                                    33


<210>  44
<211>  33
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Oligonucleotide

<400>  44
gtcatcatcc accacgcact gctgtagggc ctg                                    33


<210>  45
<211>  33
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Oligonucleotide

<400>  45
gatgatgcca acaactgcaa ggctgtggtg aag                                    33


<210>  46
<211>  33
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Oligonucleotide

<400>  46
cttcaccaca gccttgcagt tgttggcatc atc                                    33


<210>  47
<211>  33
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Oligonucleotide

<400>  47
cagttctatg accagtgtct acagcaggcc gtg                                    33


<210>  48
<211>  33
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Oligonucleotide

<400>  48
cacggcctgc tgtagacact ggtcatagaa ctg                                    33


<210>  49
<211>  33
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Oligonucleotide

<400>  49
aacaacgcca aggcttgtgt gaagaccttc cac                                    33


<210>  50
<211>  33
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Oligonucleotide

<400>  50
gtggaaggtc ttcacacaag ccttggcgtt gtt                                    33


<210>  51
<211>  34
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Oligonucleotide

<400>  51
gaccaggccc tacagtgcgc cgtggtggat gatg                                   34


<210>  52
<211>  34
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Oligonucleotide

<400>  52
catcatccac cacggcgcac tgtagggcct ggtc                                   34


<210>  53
<211>  33
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Oligonucleotide

<400>  53
gatgatgcca acaactgcaa ggctgtggtg aag                                    33


<210>  54
<211>  33
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Oligonucleotide

<400>  54
cttcaccaca gccttgcagt tgttggcatc atc                                    33


<210>  55
<211>  33
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Oligonucleotide

<400>  55
caggccctac agcagtgcgt ggtggatgat gac                                    33


<210>  56
<211>  33
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Oligonucleotide

<400>  56
gtcatcatcc accacgcact gctgtagggc ctg                                    33


<210>  57
<211>  33
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Oligonucleotide

<400>  57
gacgccaaca acgcctgtgc tgtggtgaag acc                                    33


<210>  58
<211>  33
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Oligonucleotide

<400>  58
ggtcttcacc acagcacagg cgttgttggc gtc                                    33


<210>  59
<211>  33
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Oligonucleotide

<400>  59
gaccttccac gagacgtgtg actgctgtgg ctc                                    33


<210>  60
<211>  33
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Oligonucleotide

<400>  60
gagccacagc agtcacacgt ctcgtggaag gtc                                    33


<210>  61
<211>  33
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Oligonucleotide

<400>  61
gaggactgcc accagtgtat cgatgacctc ttc                                    33


<210>  62
<211>  33
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Oligonucleotide

<400>  62
gaagaggtca tcgatacact ggtggcagtc ctc                                    33


<210>  63
<211>  34
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Oligonucleotide

<400>  63
caacaaggac cagatctgta aggatgtgaa gcag                                   34


<210>  64
<211>  34
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Oligonucleotide

<400>  64
ctgcttcaca tccttacaga tctggtcctt gttg                                   34


<210>  65
<211>  34
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Oligonucleotide

<400>  65
aagatcgatg acctctgttc cgggaagtga tgag                                   34


<210>  66
<211>  34
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Oligonucleotide

<400>  66
ctcatcactt cccggaacag aggtcatcga tctt                                   34


<210>  67
<211>  33
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Oligonucleotide

<400>  67
cagttctatg accagtgtct acagcaggcc gtg                                    33


<210>  68
<211>  33
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Oligonucleotide

<400>  68
cacggcctgc tgtagacact ggtcatagaa ctg                                    33


<210>  69
<211>  33
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Oligonucleotide

<400>  69
gatgatgcca acaactgcaa ggctgtggtg aag                                    33


<210>  70
<211>  33
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Oligonucleotide

<400>  70
cttcaccaca gccttgcagt tgttggcatc atc                                    33


<210>  71
<211>  33
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Oligonucleotide

<400>  71
ttctatgacc aggcctgcca gcaggccgtg gtg                                    33


<210>  72
<211>  33
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Oligonucleotide

<400>  72
caccacggcc tgctggcagg cctggtcata gaa                                    33


<210>  73
<211>  33
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Oligonucleotide

<400>  73
agcacactga ctgcttgtac cacctcagtg ctc                                    33


<210>  74
<211>  33
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Oligonucleotide

<400>  74
gagcactgag gtggtacaag cagtcagtgt gct                                    33


<210>  75
<211>  33
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Oligonucleotide

<400>  75
gccctacagc aggcctgtgt ggatgatgac gcc                                    33


<210>  76
<211>  33
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Oligonucleotide

<400>  76
ggcgtcatca tccacacagg cctgctgtag ggc                                    33


<210>  77
<211>  30
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Oligonucleotide

<400>  77
gctttgacca cctgtgtgct caagaacaat                                        30


<210>  78
<211>  30
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Oligonucleotide

<400>  78
attgttcttg agcacacagg tggtcaaagc                                        30


<210>  79
<211>  34
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Oligonucleotide

<400>  79
ttgaccacct cagtgtgcaa gaacaatttg tgtc                                   34


<210>  80
<211>  34
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Oligonucleotide

<400>  80
gacacaaatt gttcttgcac actgaggtgg tcaa                                   34


<210>  81
<211>  33
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Oligonucleotide

<400>  81
gtgctcaaga acaattgttg tccctcgggc agc                                    33


<210>  82
<211>  33
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Oligonucleotide

<400>  82
gctgcccgag ggacaacaat tgttcttgag cac                                    33


<210>  83
<211>  33
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Oligonucleotide

<400>  83
gactgctgtg gctcctgtac actgactgct ttg                                    33


<210>  84
<211>  33
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Oligonucleotide

<400>  84
caaagcagtc agtgtacagg agccacagca gtc                                    33


<210>  85
<211>  33
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Oligonucleotide

<400>  85
aacctcttca aggagtgttg ccaccagaag atc                                    33


<210>  86
<211>  33
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Oligonucleotide

<400>  86
gatcttctgg tggcaacact ccttgaagag gtt                                    33


<210>  87
<211>  235
<212>  PRT
<213>  Homo sapiens

<400>  87

Met Gly Val Glu Gly Cys Thr Lys Cys Ile Lys Tyr Leu Leu Phe Val 
1               5                   10                  15      


Phe Asn Phe Val Phe Trp Leu Ala Gly Gly Val Ile Leu Gly Val Ala 
            20                  25                  30          


Leu Trp Leu Arg His Asp Pro Gln Thr Thr Asn Leu Leu Tyr Leu Glu 
        35                  40                  45              


Leu Gly Asp Lys Ala Pro Asn Thr Phe Tyr Val Gly Ile Tyr Ile Leu 
    50                  55                  60                  


Ile Ala Val Gly Ala Val Met Met Phe Val Gly Phe Leu Gly Cys Tyr 
65                  70                  75                  80  


Gly Ala Ile Gln Glu Ser Gln Cys Leu Leu Gly Thr Phe Phe Thr Cys 
                85                  90                  95      


Leu Val Ile Leu Phe Ala Cys Glu Val Ala Ala Gly Ile Trp Gly Phe 
            100                 105                 110         


Val Asn Lys Asp Gln Ile Ala Lys Asp Val Lys Gln Phe Tyr Asp Gln 
        115                 120                 125             


Ala Leu Gln Gln Ala Val Val Asp Asp Asp Ala Asn Asn Ala Lys Ala 
    130                 135                 140                 


Val Val Lys Thr Phe His Glu Thr Leu Asp Cys Cys Gly Ser Ser Thr 
145                 150                 155                 160 


Leu Thr Ala Leu Thr Thr Ser Val Leu Lys Asn Asn Leu Cys Pro Ser 
                165                 170                 175     


Gly Ser Asn Ile Ile Ser Asn Leu Phe Lys Glu Asp Cys His Gln Lys 
            180                 185                 190         


Ile Asp Asp Leu Phe Ser Gly Lys Leu Tyr Leu Ile Gly Ile Ala Ala 
        195                 200                 205             


Ile Val Val Ala Val Ile Met Ile Phe Glu Met Ile Leu Ser Met Val 
    210                 215                 220                 


Leu Cys Cys Gly Ile Arg Asn Ser Ser Val Tyr 
225                 230                 235 


<210>  88
<211>  711
<212>  DNA
<213>  Homo sapiens

<400>  88
atgggagtgg agggctgcac caagtgcatc aagtacctgc tcttcgtctt caatttcgtc       60

ttctggctgg ctggaggcgt gatcctgggt gtggccctgt ggctccgcca tgacccgcag      120

accaccaacc tcctgtatct ggagctggga gacaagcccg cgcccaacac cttctatgta      180

ggcatctaca tcctcatcgc tgtgggcgct gtcatgatgt tcgttggctt cctgggctgc      240

tacggggcca tccaggaatc ccagtgcctg ctggggacgt tcttcacctg cctggtcatc      300

ctgtttgcct gtgaggtggc cgccggcatc tggggctttg tcaacaagga ccagatcgcc      360

aaggatgtga agcagttcta tgaccaggcc ctacagcagg ccgtggtgga tgatgacgcc      420

aacaacgcca aggctgtggt gaagaccttc cacgagacgc ttgactgctg tggctccagc      480

acactgactg ctttgaccac ctcagtgctc aagaacaatt tgtgtccctc gggcagcaac      540

atcatcagca acctcttcaa ggaggactgc caccagaaga tcgatgacct cttctccggg      600

aagctgtacc tcatcggcat tgctgccatc gtggtcgctg tgatcatgat cttcgagatg      660

atcctgagca tggtgctgtg ctgtggcatc cggaacagct ccgtgtactg a               711


<210>  89
<211>  228
<212>  PRT
<213>  Homo sapiens

<400>  89

Met Pro Val Lys Gly Gly Thr Lys Cys Ile Lys Tyr Leu Leu Phe Gly 
1               5                   10                  15      


Phe Asn Phe Ile Phe Trp Leu Ala Gly Ile Ala Val Leu Ala Ile Gly 
            20                  25                  30          


Leu Trp Leu Arg Phe Asp Ser Gln Thr Lys Ser Ile Phe Glu Gln Glu 
        35                  40                  45              


Thr Asn Asn Asn Asn Ser Ser Phe Tyr Thr Gly Val Tyr Ile Leu Ile 
    50                  55                  60                  


Gly Ala Gly Ala Leu Met Met Leu Val Gly Phe Leu Gly Cys Cys Gly 
65                  70                  75                  80  


Ala Val Gln Glu Ser Gln Cys Met Leu Gly Leu Phe Phe Gly Phe Leu 
                85                  90                  95      


Leu Val Ile Phe Ala Ile Glu Ile Ala Ala Ala Ile Trp Gly Tyr Ser 
            100                 105                 110         


His Lys Asp Glu Val Ile Lys Glu Val Gln Glu Phe Tyr Lys Asp Thr 
        115                 120                 125             


Tyr Asn Lys Leu Lys Thr Lys Asp Glu Pro Gln Arg Glu Thr Leu Lys 
    130                 135                 140                 


Ala Ile His Tyr Ala Leu Asn Cys Cys Gly Leu Ala Gly Gly Val Glu 
145                 150                 155                 160 


Gln Phe Ile Ser Asp Ile Cys Pro Lys Lys Asp Val Leu Glu Thr Phe 
                165                 170                 175     


Thr Val Lys Ser Cys Pro Asp Ala Ile Lys Glu Val Phe Asp Asn Lys 
            180                 185                 190         


Phe His Ile Ile Gly Ala Val Gly Ile Gly Ile Ala Val Val Met Ile 
        195                 200                 205             


Phe Gly Met Ile Phe Ser Met Ile Leu Cys Cys Ala Ile Arg Arg Asn 
    210                 215                 220                 


Arg Glu Met Val 
225             


<210>  90
<211>  219
<212>  PRT
<213>  Homo sapiens

<400>  90

Met Gly Met Ser Ser Leu Lys Leu Leu Lys Tyr Val Leu Phe Phe Phe 
1               5                   10                  15      


Asn Leu Leu Phe Trp Ile Cys Gly Cys Cys Ile Leu Gly Phe Gly Ile 
            20                  25                  30          


Tyr Leu Leu Ile His Asn Asn Phe Gly Val Leu Phe His Asn Leu Pro 
        35                  40                  45              


Ser Leu Thr Leu Gly Asn Val Phe Val Ile Val Gly Ser Ile Ile Met 
    50                  55                  60                  


Val Val Ala Phe Leu Gly Cys Met Gly Ser Ile Lys Glu Asn Lys Cys 
65                  70                  75                  80  


Leu Leu Met Ser Phe Phe Ile Leu Leu Leu Ile Ile Leu Leu Ala Glu 
                85                  90                  95      


Val Thr Leu Ala Ile Leu Leu Phe Val Tyr Glu Gln Lys Leu Asn Glu 
            100                 105                 110         


Tyr Val Ala Lys Gly Leu Thr Asp Ser Ile His Arg Tyr His Ser Asp 
        115                 120                 125             


Asn Ser Thr Lys Ala Ala Trp Asp Ser Ile Gln Ser Phe Leu Gln Cys 
    130                 135                 140                 


Cys Gly Ile Asn Gly Thr Ser Asp Trp Thr Ser Gly Pro Pro Ala Ser 
145                 150                 155                 160 


Cys Pro Ser Asp Arg Lys Val Glu Gly Cys Tyr Ala Lys Ala Arg Leu 
                165                 170                 175     


Trp Phe His Ser Asn Phe Leu Tyr Ile Gly Ile Ile Thr Ile Cys Val 
            180                 185                 190         


Cys Val Ile Glu Val Leu Gly Met Ser Phe Ala Leu Thr Leu Asn Cys 
        195                 200                 205             


Gln Ile Asp Lys Thr Ser Gln Thr Ile Gly Leu 
    210                 215                 


<210>  91
<211>  320
<212>  PRT
<213>  Homo sapiens

<400>  91

Met Gly Pro Trp Ser Arg Val Arg Val Ala Lys Cys Gln Met Leu Val 
1               5                   10                  15      


Thr Cys Phe Phe Ile Leu Leu Leu Gly Leu Ser Val Ala Thr Met Val 
            20                  25                  30          


Thr Leu Thr Tyr Phe Gly Ala His Phe Ala Val Ile Arg Arg Ala Ser 
        35                  40                  45              


Leu Glu Lys Asn Pro Tyr Gln Ala Val His Gln Trp Ala Phe Ser Ala 
    50                  55                  60                  


Gly Leu Ser Leu Val Gly Leu Leu Thr Leu Gly Ala Val Leu Ser Ala 
65                  70                  75                  80  


Ala Ala Thr Val Arg Glu Ala Gln Gly Leu Met Ala Gly Gly Phe Leu 
                85                  90                  95      


Cys Phe Ser Leu Ala Phe Cys Ala Gln Val Gln Val Val Phe Trp Arg 
            100                 105                 110         


Leu His Ser Pro Thr Gln Val Glu Asp Ala Met Leu Asp Thr Tyr Asp 
        115                 120                 125             


Leu Val Tyr Glu Gln Ala Met Lys Gly Thr Ser His Val Arg Arg Gln 
    130                 135                 140                 


Glu Leu Ala Ala Ile Gln Asp Val Phe Leu Cys Cys Gly Lys Lys Ser 
145                 150                 155                 160 


Pro Phe Ser Arg Leu Gly Ser Thr Glu Ala Asp Leu Cys Gln Gly Glu 
                165                 170                 175     


Glu Ala Ala Arg Glu Asp Cys Leu Gln Gly Ile Arg Ser Phe Leu Arg 
            180                 185                 190         


Thr His Gln Gln Val Ala Ser Ser Leu Thr Ser Ile Gly Leu Ala Leu 
        195                 200                 205             


Thr Val Ser Ala Leu Leu Phe Ser Ser Phe Leu Trp Phe Ala Ile Arg 
    210                 215                 220                 


Cys Gly Cys Ser Leu Asp Arg Lys Gly Lys Tyr Thr Leu Thr Pro Arg 
225                 230                 235                 240 


Ala Cys Gly Arg Gln Pro Gln Glu Pro Ser Leu Leu Arg Cys Ser Gln 
                245                 250                 255     


Gly Gly Pro Thr His Cys Leu His Ser Glu Ala Val Ala Ile Gly Pro 
            260                 265                 270         


Arg Gly Cys Ser Gly Ser Leu Arg Trp Leu Gln Glu Ser Asp Ala Ala 
        275                 280                 285             


Pro Leu Pro Leu Ser Cys His Leu Ala Ala His Arg Ala Leu Gln Gly 
    290                 295                 300                 


Arg Ser Arg Gly Gly Leu Ser Gly Cys Pro Glu Arg Gly Leu Ser Asp 
305                 310                 315                 320 


<210>  92
<211>  267
<212>  PRT
<213>  Homo sapiens

<400>  92

Met Gly Ser Ala Cys Ile Lys Val Thr Lys Tyr Phe Leu Phe Leu Phe 
1               5                   10                  15      


Asn Leu Ile Phe Phe Ile Leu Gly Ala Val Ile Leu Gly Phe Gly Val 
            20                  25                  30          


Trp Ile Leu Ala Asp Lys Ser Ser Phe Ile Ser Val Leu Gln Thr Ser 
        35                  40                  45              


Ser Ser Ser Leu Arg Met Gly Ala Tyr Val Phe Ile Gly Val Gly Ala 
    50                  55                  60                  


Val Thr Met Leu Met Gly Phe Leu Gly Cys Ile Gly Ala Val Asn Glu 
65                  70                  75                  80  


Val Arg Cys Leu Leu Gly Leu Tyr Phe Ala Phe Leu Leu Leu Ile Leu 
                85                  90                  95      


Ile Ala Gln Val Thr Ala Gly Ala Leu Phe Tyr Phe Asn Met Gly Lys 
            100                 105                 110         


Leu Lys Gln Glu Met Gly Gly Ile Val Thr Glu Leu Ile Arg Asp Tyr 
        115                 120                 125             


Asn Ser Ser Arg Glu Asp Ser Leu Gln Asp Ala Trp Asp Tyr Val Gln 
    130                 135                 140                 


Ala Gln Val Lys Cys Cys Gly Trp Val Ser Phe Tyr Asn Trp Thr Asp 
145                 150                 155                 160 


Asn Ala Glu Leu Met Asn Arg Pro Glu Val Thr Tyr Pro Cys Ser Cys 
                165                 170                 175     


Glu Val Lys Gly Glu Glu Asp Asn Ser Leu Ser Val Arg Lys Gly Phe 
            180                 185                 190         


Cys Glu Ala Pro Gly Asn Arg Thr Gln Ser Gly Asn His Pro Glu Asp 
        195                 200                 205             


Trp Pro Val Tyr Gln Glu Gly Cys Met Glu Lys Val Gln Ala Trp Leu 
    210                 215                 220                 


Gln Glu Asn Leu Gly Ile Ile Leu Gly Val Gly Val Gly Val Ala Ile 
225                 230                 235                 240 


Ile Glu Leu Leu Gly Met Val Leu Ser Ile Cys Leu Cys Arg His Val 
                245                 250                 255     


His Ser Glu Asp Tyr Ser Lys Val Pro Lys Tyr 
            260                 265         


<210>  93
<211>  238
<212>  PRT
<213>  Homo sapiens

<400>  93

Met Ala Val Glu Gly Gly Met Lys Cys Val Lys Phe Leu Leu Tyr Val 
1               5                   10                  15      


Leu Leu Leu Ala Phe Cys Ala Cys Ala Val Gly Leu Ile Ala Val Gly 
            20                  25                  30          


Val Gly Ala Gln Leu Val Leu Ser Gln Thr Ile Ile Gln Gly Ala Thr 
        35                  40                  45              


Pro Gly Ser Leu Leu Pro Val Val Ile Ile Ala Val Gly Val Phe Leu 
    50                  55                  60                  


Phe Leu Val Ala Phe Val Gly Cys Cys Gly Ala Cys Lys Glu Asn Tyr 
65                  70                  75                  80  


Cys Leu Met Ile Thr Phe Ala Ile Phe Leu Ser Leu Ile Met Leu Val 
                85                  90                  95      


Glu Val Ala Ala Ala Ile Ala Gly Tyr Val Phe Arg Asp Lys Val Met 
            100                 105                 110         


Ser Glu Phe Asn Asn Asn Phe Arg Gln Gln Met Glu Asn Tyr Pro Lys 
        115                 120                 125             


Asn Asn His Thr Ala Ser Ile Leu Asp Arg Met Gln Ala Asp Phe Lys 
    130                 135                 140                 


Cys Cys Gly Ala Ala Asn Tyr Thr Asp Trp Glu Lys Ile Pro Ser Met 
145                 150                 155                 160 


Ser Lys Asn Arg Val Pro Asp Ser Cys Cys Ile Asn Val Thr Val Gly 
                165                 170                 175     


Cys Gly Ile Asn Phe Asn Glu Lys Ala Ile His Lys Glu Gly Cys Val 
            180                 185                 190         


Glu Lys Ile Gly Gly Trp Leu Arg Lys Asn Val Leu Val Val Ala Ala 
        195                 200                 205             


Ala Ala Leu Gly Ile Ala Phe Val Glu Val Leu Gly Ile Val Phe Ala 
    210                 215                 220                 


Cys Cys Leu Val Lys Ser Ile Arg Ser Gly Tyr Glu Val Met 
225                 230                 235             


<210>  94
<211>  253
<212>  PRT
<213>  Homo sapiens

<400>  94

Met Gly Glu Phe Asn Glu Lys Lys Thr Thr Cys Gly Thr Val Cys Leu 
1               5                   10                  15      


Lys Tyr Leu Leu Phe Thr Tyr Asn Cys Cys Phe Trp Leu Ala Gly Leu 
            20                  25                  30          


Ala Val Met Ala Val Gly Ile Trp Thr Leu Ala Leu Lys Ser Asp Tyr 
        35                  40                  45              


Ile Ser Leu Leu Ala Ser Gly Thr Tyr Leu Ala Thr Ala Tyr Ile Leu 
    50                  55                  60                  


Val Val Ala Gly Thr Val Val Met Val Thr Gly Val Leu Gly Cys Cys 
65                  70                  75                  80  


Ala Thr Phe Lys Glu Arg Arg Asn Leu Leu Arg Leu Tyr Phe Ile Leu 
                85                  90                  95      


Leu Leu Ile Ile Phe Leu Leu Glu Ile Ile Ala Gly Ile Leu Ala Tyr 
            100                 105                 110         


Ala Tyr Tyr Gln Gln Leu Asn Thr Glu Leu Lys Glu Asn Leu Lys Asp 
        115                 120                 125             


Thr Met Thr Lys Arg Tyr His Gln Pro Gly His Glu Ala Val Thr Ser 
    130                 135                 140                 


Ala Val Asp Gln Leu Gln Gln Glu Phe His Cys Cys Gly Ser Asn Asn 
145                 150                 155                 160 


Ser Gln Asp Trp Arg Asp Ser Glu Trp Ile Arg Ser Gln Glu Ala Gly 
                165                 170                 175     


Gly Arg Val Val Pro Asp Ser Cys Cys Lys Thr Val Val Ala Leu Cys 
            180                 185                 190         


Gly Gln Arg Asp His Ala Ser Asn Ile Tyr Lys Val Glu Gly Gly Cys 
        195                 200                 205             


Ile Thr Lys Leu Glu Thr Phe Ile Gln Glu His Leu Arg Val Ile Gly 
    210                 215                 220                 


Ala Val Gly Ile Gly Ile Ala Cys Val Gln Val Phe Gly Met Ile Phe 
225                 230                 235                 240 


Thr Cys Cys Leu Tyr Arg Ser Leu Lys Leu Glu His Tyr 
                245                 250             


<210>  95
<211>  281
<212>  PRT
<213>  Homo sapiens

<400>  95

Met Ser Ala Gln Glu Ser Cys Leu Ser Leu Ile Lys Tyr Phe Leu Phe 
1               5                   10                  15      


Val Phe Asn Leu Phe Phe Phe Val Leu Gly Ser Leu Ile Phe Cys Phe 
            20                  25                  30          


Gly Ile Trp Ile Leu Ile Asp Lys Thr Ser Phe Val Ser Phe Val Gly 
        35                  40                  45              


Leu Ala Phe Val Pro Leu Gln Ile Trp Ser Lys Val Leu Ala Ile Ser 
    50                  55                  60                  


Gly Ile Phe Thr Met Gly Ile Ala Leu Leu Gly Cys Val Gly Ala Leu 
65                  70                  75                  80  


Lys Glu Leu Arg Cys Leu Leu Gly Leu Tyr Phe Gly Met Leu Leu Leu 
                85                  90                  95      


Leu Phe Ala Thr Gln Ile Thr Leu Gly Ile Leu Ile Ser Thr Gln Arg 
            100                 105                 110         


Ala Gln Leu Glu Arg Ser Leu Arg Asp Val Val Glu Lys Thr Ile Gln 
        115                 120                 125             


Lys Tyr Gly Thr Asn Pro Glu Glu Thr Ala Ala Glu Glu Ser Trp Asp 
    130                 135                 140                 


Tyr Val Gln Phe Gln Leu Arg Cys Cys Gly Trp His Tyr Pro Gln Asp 
145                 150                 155                 160 


Trp Phe Gln Val Leu Ile Leu Arg Gly Asn Gly Ser Glu Ala His Arg 
                165                 170                 175     


Val Pro Cys Ser Cys Tyr Asn Leu Ser Ala Thr Asn Asp Ser Thr Ile 
            180                 185                 190         


Leu Asp Lys Val Ile Leu Pro Gln Leu Ser Arg Leu Gly His Leu Ala 
        195                 200                 205             


Arg Ser Arg His Ser Ala Asp Ile Cys Ala Val Pro Ala Glu Ser His 
    210                 215                 220                 


Ile Tyr Arg Glu Gly Cys Ala Gln Gly Leu Gln Lys Trp Leu His Asn 
225                 230                 235                 240 


Asn Leu Ile Ser Ile Val Gly Ile Cys Leu Gly Val Gly Leu Leu Glu 
                245                 250                 255     


Leu Gly Phe Met Thr Leu Ser Ile Phe Leu Cys Arg Asn Leu Asp His 
            260                 265                 270         


Val Tyr Asn Arg Leu Ala Arg Tyr Arg 
        275                 280     


<210>  96
<211>  410
<212>  PRT
<213>  Homo sapiens

<400>  96

Met Val Cys Phe Arg Leu Phe Pro Val Pro Gly Ser Gly Leu Val Leu 
1               5                   10                  15      


Val Cys Leu Val Leu Gly Ala Val Arg Ser Tyr Ala Leu Glu Leu Asn 
            20                  25                  30          


Leu Thr Asp Ser Glu Asn Ala Thr Cys Leu Tyr Ala Lys Trp Gln Met 
        35                  40                  45              


Asn Phe Thr Val Arg Tyr Glu Thr Thr Asn Lys Thr Tyr Lys Thr Val 
    50                  55                  60                  


Thr Ile Ser Asp His Gly Thr Val Thr Tyr Asn Gly Ser Ile Cys Gly 
65                  70                  75                  80  


Asp Asp Gln Asn Gly Pro Lys Ile Ala Val Gln Phe Gly Pro Gly Phe 
                85                  90                  95      


Ser Trp Ile Ala Asn Phe Thr Lys Ala Ala Ser Thr Tyr Ser Ile Asp 
            100                 105                 110         


Ser Val Ser Phe Ser Tyr Asn Thr Gly Asp Asn Thr Thr Phe Pro Asp 
        115                 120                 125             


Ala Glu Asp Lys Gly Ile Leu Thr Val Asp Glu Leu Leu Ala Ile Arg 
    130                 135                 140                 


Ile Pro Leu Asn Asp Leu Phe Arg Cys Asn Ser Leu Ser Thr Leu Glu 
145                 150                 155                 160 


Lys Asn Asp Val Val Gln His Tyr Trp Asp Val Leu Val Gln Ala Phe 
                165                 170                 175     


Val Gln Asn Gly Thr Val Ser Thr Asn Glu Phe Leu Cys Asp Lys Asp 
            180                 185                 190         


Lys Thr Ser Thr Val Ala Pro Thr Ile His Thr Thr Val Pro Ser Pro 
        195                 200                 205             


Thr Thr Thr Pro Thr Pro Lys Glu Lys Pro Glu Ala Gly Thr Tyr Ser 
    210                 215                 220                 


Val Asn Asn Gly Asn Asp Thr Cys Leu Leu Ala Thr Met Gly Leu Gln 
225                 230                 235                 240 


Leu Asn Ile Thr Gln Asp Lys Val Ala Ser Val Ile Asn Ile Asn Pro 
                245                 250                 255     


Asn Thr Thr His Ser Thr Gly Ser Cys Arg Ser His Thr Ala Leu Leu 
            260                 265                 270         


Arg Leu Asn Ser Ser Thr Ile Lys Tyr Leu Asp Phe Val Phe Ala Val 
        275                 280                 285             


Lys Asn Glu Asn Arg Phe Tyr Leu Lys Glu Val Asn Ile Ser Met Tyr 
    290                 295                 300                 


Leu Val Asn Gly Ser Val Phe Ser Ile Ala Asn Asn Asn Leu Ser Tyr 
305                 310                 315                 320 


Trp Asp Ala Pro Leu Gly Ser Ser Tyr Met Cys Asn Lys Glu Gln Thr 
                325                 330                 335     


Val Ser Val Ser Gly Ala Phe Gln Ile Asn Thr Phe Asp Leu Arg Val 
            340                 345                 350         


Gln Pro Phe Asn Val Thr Gln Gly Lys Tyr Ser Thr Ala Gln Glu Cys 
        355                 360                 365             


Ser Leu Asp Asp Asp Thr Ile Leu Ile Pro Ile Ile Val Gly Ala Gly 
    370                 375                 380                 


Leu Ser Gly Leu Ile Ile Val Ile Val Ile Ala Tyr Val Ile Gly Arg 
385                 390                 395                 400 


Arg Lys Ser Tyr Ala Gly Tyr Gln Thr Leu 
                405                 410 


<210>  97
<211>  89
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD81 LEL mutant


<220>
<221>  MISC_FEATURE
<222>  (20)..(21)
<223>  X can be any amino acid

<220>
<221>  MISC_FEATURE
<222>  (24)..(29)
<223>  X can be any amino acid

<220>
<221>  MISC_FEATURE
<222>  (50)..(53)
<223>  X can be any amino acid

<220>
<221>  MISC_FEATURE
<222>  (55)..(55)
<223>  X can be any amino acid

<220>
<221>  MISC_FEATURE
<222>  (59)..(60)
<223>  X can be any amino acid

<400>  97

Phe Val Asn Lys Asp Gln Ile Ala Lys Asp Val Lys Gln Phe Tyr Asp 
1               5                   10                  15      


Gln Cys Leu Xaa Xaa Ala Cys Xaa Xaa Xaa Xaa Xaa Xaa Asn Ala Lys 
            20                  25                  30          


Ala Cys Val Lys Thr Phe His Glu Thr Leu Asp Cys Cys Gly Ser Ser 
        35                  40                  45              


Thr Xaa Xaa Xaa Xaa Thr Xaa Cys Val Leu Xaa Xaa Asn Leu Cys Pro 
    50                  55                  60                  


Ser Gly Ser Asn Ile Ile Ser Asn Leu Phe Lys Glu Asp Cys His Gln 
65                  70                  75                  80  


Lys Ile Asp Asp Leu Phe Ser Gly Lys 
                85                  


<210>  98
<211>  78
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CD81 LEL mutant


<220>
<221>  misc_feature
<222>  (34)..(35)
<223>  N is any one of A, C, G, or T

<220>
<221>  misc_feature
<222>  (37)..(38)
<223>  N is any one of A, C, G, or T

<220>
<221>  misc_feature
<222>  (46)..(47)
<223>  N is any one of A, C, G, or T

<220>
<221>  misc_feature
<222>  (49)..(50)
<223>  N is any one of A, C, G, or T

<220>
<221>  misc_feature
<222>  (52)..(53)
<223>  N is any one of A, C, G, or T

<220>
<221>  misc_feature
<222>  (55)..(56)
<223>  N is any one of A, C, G, or T

<400>  98
aaggatgtga agcagttcta tgaccaagct ttannknnkt gctgtnnknn knnknnkgcc       60

aacaacgcct gtgctgtg                                                     78


<210>  99
<211>  96
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CD81 LEL mutant


<220>
<221>  misc_feature
<222>  (46)..(46)
<223>  M is any one of A or C

<220>
<221>  misc_feature
<222>  (47)..(48)
<223>  N is any one of A, C, G, or T

<220>
<221>  misc_feature
<222>  (49)..(49)
<223>  M is any one of A or C

<220>
<221>  misc_feature
<222>  (50)..(51)
<223>  N is any one of A, C, G, or T

<220>
<221>  misc_feature
<222>  (61)..(61)
<223>  M is any one of A or C

<220>
<221>  misc_feature
<222>  (62)..(63)
<223>  N is any one of A, C, G, or T

<220>
<221>  misc_feature
<222>  (67)..(67)
<223>  M is any one of A or C

<220>
<221>  misc_feature
<222>  (68)..(69)
<223>  N is any one of A, C, G, or T

<220>
<221>  misc_feature
<222>  (70)..(70)
<223>  M is any one of A or C

<220>
<221>  misc_feature
<222>  (71)..(72)
<223>  N is any one of A, C, G, or T

<220>
<221>  misc_feature
<222>  (73)..(73)
<223>  M is any one of A or C

<220>
<221>  misc_feature
<222>  (74)..(75)
<223>  N is any one of A, C, G, or T

<220>
<221>  misc_feature
<222>  (76)..(76)
<223>  M is any one of A or C

<220>
<221>  misc_feature
<222>  (77)..(78)
<223>  N is any one of A, C, G, or T

<400>  99
cttgaagagg ttgctgatga tgttggatcc cgagggacac aaattmnnmn ngagcacaca       60

mnnggtmnnm nnmnnmnntg tgctggagcc acagca                                 96


<210>  100
<211>  81
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CD81 LEL mutant


<220>
<221>  misc_feature
<222>  (34)..(35)
<223>  N is any one of A, C, G, or T

<220>
<221>  misc_feature
<222>  (37)..(38)
<223>  N is any one of A, C, G, or T

<220>
<221>  misc_feature
<222>  (46)..(47)
<223>  N is any one of A, C, G, or T

<220>
<221>  misc_feature
<222>  (49)..(50)
<223>  N is any one of A, C, G, or T

<220>
<221>  misc_feature
<222>  (52)..(53)
<223>  N is any one of A, C, G, or T

<220>
<221>  misc_feature
<222>  (55)..(56)
<223>  N is any one of A, C, G, or T

<220>
<221>  misc_feature
<222>  (58)..(59)
<223>  N is any one of A, C, G, or T

<220>
<221>  misc_feature
<222>  (61)..(62)
<223>  N is any one of A, C, G, or T

<400>  100
aaggatgtga agcagttcta tgaccagtgt ctannknnkg cctgtnnknn knnknnknnk       60

nnkaacgcca aggcttgtgt g                                                 81


<210>  101
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer

<400>  101
agtaacgttt gtcagtaatt gc                                                22


<210>  102
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer

<400>  102
gtcgattttg ttacatctac ac                                                22


<210>  103
<211>  89
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD81 LEL mutant

<400>  103

Phe Val Asn Lys Asp Gln Ile Ala Lys Asp Val Lys Gln Phe Tyr Asp 
1               5                   10                  15      


Gln Ala Leu Trp Trp Cys Cys Val Leu Tyr Lys Ala Asn Asn Ala Cys 
            20                  25                  30          


Ala Val Val Lys Thr Phe His Glu Thr Leu Asp Cys Cys Gly Ser Ser 
        35                  40                  45              


Thr Gly Arg Ser His Thr Ala Cys Val Leu Lys Gly Asn Leu Cys Pro 
    50                  55                  60                  


Ser Gly Ser Asn Ile Ile Ser Asn Leu Phe Lys Glu Asp Cys His Gln 
65                  70                  75                  80  


Lys Ile Asp Asp Leu Phe Ser Gly Lys 
                85                  


<210>  104
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer

<400>  104
cttgaagagg ttgctgat                                                     18


<210>  105
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer

<400>  105
aaggatgtga agcagttc                                                     18


<210>  106
<211>  31
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  oligonucleotide

<400>  106
acgtgctagc tttgtcaaca aggaccagat c                                      31


<210>  107
<211>  41
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  oligonucleotide

<400>  107
acgtggtgac cggtgctgga acccttcccg gagaagaggt c                           41


<210>  108
<211>  89
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD81 LEL mutant

<400>  108

Phe Val Asn Lys Asp Gln Ile Ala Lys Asp Val Lys Gln Phe Tyr Asp 
1               5                   10                  15      


Gln Ala Leu Arg Glu Cys Cys Asn Thr Phe Asp Ala Asn Asn Ala Cys 
            20                  25                  30          


Ala Val Val Lys Thr Phe His Glu Thr Leu Asp Cys Cys Gly Ser Ser 
        35                  40                  45              


Thr Thr His Ser Ser Thr Gly Cys Val Leu Phe Phe Asn Leu Cys Pro 
    50                  55                  60                  


Ser Gly Ser Asn Ile Ile Ser Asn Leu Phe Lys Glu Asp Cys His Gln 
65                  70                  75                  80  


Lys Ile Asp Asp Leu Phe Ser Gly Lys 
                85                  


<210>  109
<211>  89
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD81 LEL mutant

<400>  109

Phe Val Asn Lys Asp Gln Ile Ala Lys Asp Val Lys Gln Phe Tyr Asp 
1               5                   10                  15      


Gln Ala Leu Met Ile Cys Cys His Arg His Tyr Ala Asn Asn Ala Cys 
            20                  25                  30          


Ala Val Val Lys Thr Phe His Glu Thr Leu Asp Cys Cys Gly Ser Ser 
        35                  40                  45              


Thr Pro Ser Ser Thr Thr Pro Cys Val Leu Gln Asn Asn Leu Cys Pro 
    50                  55                  60                  


Ser Gly Ser Asn Ile Ile Ser Asn Leu Phe Lys Glu Asp Cys His Gln 
65                  70                  75                  80  


Lys Ile Asp Asp Leu Phe Ser Gly Lys 
                85                  


<210>  110
<211>  89
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD81 LEL mutant

<400>  110

Phe Val Asn Lys Asp Gln Ile Ala Lys Asp Val Lys Gln Phe Tyr Asp 
1               5                   10                  15      


Gln Ala Leu Val Phe Cys Cys Phe Gly Gly His Ala Asn Asn Ala Cys 
            20                  25                  30          


Ala Val Val Lys Thr Phe His Glu Thr Leu Asp Cys Cys Gly Ser Ser 
        35                  40                  45              


Thr His Pro Tyr Lys Thr Lys Cys Val Leu Gln Arg Asn Leu Cys Pro 
    50                  55                  60                  


Ser Gly Ser Asn Ile Ile Ser Asn Leu Phe Lys Glu Asp Cys His Gln 
65                  70                  75                  80  


Lys Ile Asp Asp Leu Phe Ser Gly Lys 
                85                  


<210>  111
<211>  89
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD81 LEL mutant

<400>  111

Phe Val Asn Lys Asp Gln Ile Ala Lys Asp Val Lys Gln Phe Tyr Asp 
1               5                   10                  15      


Gln Cys Leu Lys Tyr Ala Cys Lys Gln Gly Asp Trp Glu Asn Ala Lys 
            20                  25                  30          


Ala Cys Val Lys Thr Phe His Glu Thr Leu Asp Cys Cys Gly Ser Ser 
        35                  40                  45              


Thr Val Ala Asn Met Thr Arg Cys Val Leu Pro Ala Asn Leu Cys Pro 
    50                  55                  60                  


Ser Gly Ser Asn Ile Ile Ser Asn Leu Phe Lys Glu Asp Cys His Gln 
65                  70                  75                  80  


Lys Ile Asp Asp Leu Phe Ser Gly Lys 
                85                  


<210>  112
<211>  89
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD81 LEL mutant

<400>  112

Phe Val Asn Lys Asp Gln Ile Ala Lys Asp Val Lys Gln Phe Tyr Asp 
1               5                   10                  15      


Gln Cys Leu Leu Trp Ala Cys Ser Lys Arg Tyr Lys Tyr Asn Ala Lys 
            20                  25                  30          


Ala Cys Val Lys Thr Phe His Glu Thr Leu Asp Cys Cys Gly Ser Ser 
        35                  40                  45              


Thr Met Gly Asn Leu Thr Glu Cys Val Leu Ile Glu Asn Leu Cys Pro 
    50                  55                  60                  


Ser Gly Ser Asn Ile Ile Ser Asn Leu Phe Lys Glu Asp Cys His Gln 
65                  70                  75                  80  


Lys Ile Asp Asp Leu Phe Ser Gly Lys 
                85                  


<210>  113
<211>  89
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD81 LEL mutant

<400>  113

Phe Val Asn Lys Asp Gln Ile Ala Lys Asp Val Lys Gln Phe Tyr Asp 
1               5                   10                  15      


Gln Ala Leu Trp Lys Cys Cys Asn Leu Ser Gln Ala Asn Asn Ala Cys 
            20                  25                  30          


Ala Val Val Lys Thr Phe His Glu Thr Leu Asp Cys Cys Gly Ser Ser 
        35                  40                  45              


Thr Tyr Leu Cys Ala Thr Tyr Cys Val Leu Trp Pro Asn Leu Cys Pro 
    50                  55                  60                  


Ser Gly Ser Asn Ile Ile Ser Asn Leu Phe Lys Glu Asp Cys His Gln 
65                  70                  75                  80  


Lys Ile Asp Asp Leu Phe Ser Gly Lys 
                85                  


<210>  114
<211>  89
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD81 LEL mutant

<400>  114

Phe Val Asn Lys Asp Gln Ile Ala Lys Asp Val Lys Gln Phe Tyr Asp 
1               5                   10                  15      


Gln Cys Leu Ser Trp Ala Cys Asn Arg Lys Tyr Glu Pro Asn Ala Lys 
            20                  25                  30          


Ala Cys Val Lys Thr Phe His Glu Thr Leu Asp Cys Cys Gly Ser Ser 
        35                  40                  45              


Thr Lys Ala Asn Tyr Thr His Cys Val Leu Glu Met Asn Leu Cys Pro 
    50                  55                  60                  


Ser Gly Ser Asn Ile Ile Ser Asn Leu Phe Lys Glu Asp Cys His Gln 
65                  70                  75                  80  


Lys Ile Asp Asp Leu Phe Ser Gly Lys 
                85                  


<210>  115
<211>  89
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD81 LEL mutant

<400>  115

Phe Val Asn Lys Asp Gln Ile Ala Lys Asp Val Lys Gln Phe Tyr Asp 
1               5                   10                  15      


Gln Cys Leu Arg His Ala Cys Ser Gly Leu Ser Gly Arg Asn Ala Lys 
            20                  25                  30          


Ala Cys Val Lys Thr Phe His Glu Thr Leu Asp Cys Cys Gly Ser Ser 
        35                  40                  45              


Thr Ile Lys His Lys Thr Leu Cys Val Leu Ile Lys Asn Leu Cys Pro 
    50                  55                  60                  


Ser Gly Ser Asn Ile Ile Ser Asn Leu Phe Lys Glu Asp Cys His Gln 
65                  70                  75                  80  


Lys Ile Asp Asp Leu Phe Ser Gly Lys 
                85                  


<210>  116
<211>  89
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD81 LEL mutant

<400>  116

Phe Val Asn Lys Asp Gln Ile Ala Lys Asp Val Lys Gln Phe Tyr Asp 
1               5                   10                  15      


Gln Ala Leu Phe Ile Cys Cys Phe Arg Arg Tyr Ala Asn Asn Ala Cys 
            20                  25                  30          


Ala Val Val Lys Thr Phe His Glu Thr Leu Asp Cys Cys Gly Ser Ser 
        35                  40                  45              


Thr Arg Asn Asn Glu Thr Ala Cys Val Leu Ala Lys Asn Leu Cys Pro 
    50                  55                  60                  


Ser Gly Ser Asn Ile Ile Ser Asn Leu Phe Lys Glu Asp Cys His Gln 
65                  70                  75                  80  


Lys Ile Asp Asp Leu Phe Ser Gly Lys 
                85                  


<210>  117
<211>  89
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD81 LEL mutant

<400>  117

Phe Val Asn Lys Asp Gln Ile Ala Lys Asp Val Lys Gln Phe Tyr Asp 
1               5                   10                  15      


Gln Ala Leu Val Asn Cys Cys Tyr Thr Arg Ala Ala Asn Asn Ala Cys 
            20                  25                  30          


Ala Val Val Lys Thr Phe His Glu Thr Leu Asp Cys Cys Gly Ser Ser 
        35                  40                  45              


Thr His Tyr Val Asp Thr His Cys Val Leu Asn Arg Asn Leu Cys Pro 
    50                  55                  60                  


Ser Gly Ser Asn Ile Ile Ser Asn Leu Phe Lys Glu Asp Cys His Gln 
65                  70                  75                  80  


Lys Ile Asp Asp Leu Phe Ser Gly Lys 
                85                  


<210>  118
<211>  80
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  oligonucleotides

<400>  118

His Lys Asp Glu Val Ile Lys Glu Val Gln Glu Phe Tyr Lys Asp Thr 
1               5                   10                  15      


Tyr Asn Lys Leu Lys Thr Lys Asp Glu Pro Gln Arg Glu Thr Leu Lys 
            20                  25                  30          


Ala Ile His Tyr Ala Leu Asn Cys Cys Gly Leu Ala Gly Gly Val Glu 
        35                  40                  45              


Gln Phe Ile Ser Asp Ile Cys Pro Lys Lys Asp Val Leu Glu Thr Phe 
    50                  55                  60                  


Thr Val Lys Ser Cys Pro Asp Ala Ile Lys Glu Val Phe Asp Asn Lys 
65                  70                  75                  80  


<210>  119
<211>  31
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  oligonucleotides

<400>  119
acgtgctagc cacaaggatg aggtgattaa g                                      31


<210>  120
<211>  41
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  oligonucleotides

<400>  120
acgtggtgac cggtgctgga acctttattg tcgaagacct c                           41


<210>  121
<211>  33
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  oligonucleotides

<400>  121
gacacctaca acaagtgcaa aaccaaggat gag                                    33


<210>  122
<211>  33
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  oligonucleotides

<400>  122
ctcatccttg gttttgcact tgttgtaggt gtc                                    33


<210>  123
<211>  33
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  oligonucleotides

<400>  123
aaggatgagc cccagtgtga aacgctgaaa gcc                                    33


<210>  124
<211>  33
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  oligonucleotides

<400>  124
ggctttcagc gtttcacact ggggctcatc ctt                                    33


<210>  125
<211>  80
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD9 LEL mutant

<400>  125

His Lys Asp Glu Val Ile Lys Glu Val Gln Glu Phe Tyr Lys Asp Thr 
1               5                   10                  15      


Tyr Asn Lys Cys Lys Thr Lys Asp Glu Pro Gln Cys Glu Thr Leu Lys 
            20                  25                  30          


Ala Ile His Tyr Ala Leu Asn Cys Cys Gly Leu Ala Gly Gly Val Glu 
        35                  40                  45              


Gln Phe Ile Ser Asp Ile Cys Pro Lys Lys Asp Val Leu Glu Thr Phe 
    50                  55                  60                  


Thr Val Lys Ser Cys Pro Asp Ala Ile Lys Glu Val Phe Asp Asn Lys 
65                  70                  75                  80  


<210>  126
<211>  31
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  oligonucleotides

<400>  126
acgtggatcc cacaaggatg aggtgattaa g                                      31


<210>  127
<211>  32
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  oligonucleotides

<400>  127
acgtgcggcc gcgctttatt gtcgaagacc tc                                     32


<210>  128
<211>  99
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CD9 LEL mutant


<220>
<221>  misc_feature
<222>  (52)..(53)
<223>  N is any one of A, C, G, or T

<220>
<221>  misc_feature
<222>  (55)..(56)
<223>  N is any one of A, C, G, or T

<220>
<221>  misc_feature
<222>  (61)..(62)
<223>  N is any one of A, C, G, or T

<220>
<221>  misc_feature
<222>  (64)..(65)
<223>  N is any one of A, C, G, or T

<220>
<221>  misc_feature
<222>  (67)..(68)
<223>  N is any one of A, C, G, or T

<220>
<221>  misc_feature
<222>  (70)..(71)
<223>  N is any one of A, C, G, or T

<220>
<221>  misc_feature
<222>  (73)..(74)
<223>  N is any one of A, C, G, or T

<220>
<221>  misc_feature
<222>  (79)..(80)
<223>  N is any one of A, C, G, or T

<400>  128
cacaaggatg aggtgattaa ggaagtccag gagttttaca aggacaccta cnnknnktgc       60

nnknnknnkn nknnkcccnn ktgtgaaacg ctgaaagcc                              99


<210>  129
<211>  52
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  oligonucleotides

<400>  129
cttcgaaggg ccctctagac tcgagcggcc gcgctttatt gtcgaagacc tc               52


<210>  130
<211>  22
<212>  PRT
<213>  Homo sapiens

<400>  130

His Asp Pro Gln Thr Thr Asn Leu Leu Tyr Leu Glu Leu Gly Asp Lys 
1               5                   10                  15      


Ala Pro Asn Thr Phe Tyr 
            20          


<210>  131
<211>  89
<212>  PRT
<213>  Homo sapiens

<400>  131

Phe Val Asn Lys Asp Gln Ile Ala Lys Asp Val Lys Gln Phe Tyr Asp 
1               5                   10                  15      


Gln Ala Leu Gln Gln Ala Val Val Asp Asp Asp Ala Asn Asn Ala Lys 
            20                  25                  30          


Ala Val Val Lys Thr Phe His Glu Thr Leu Asp Cys Cys Gly Ser Ser 
        35                  40                  45              


Thr Leu Thr Ala Leu Thr Thr Ser Val Leu Lys Asn Asn Leu Cys Pro 
    50                  55                  60                  


Ser Gly Ser Asn Ile Ile Ser Asn Leu Phe Lys Glu Asp Cys His Gln 
65                  70                  75                  80  


Lys Ile Asp Asp Leu Phe Ser Gly Lys 
                85                  


<210>  132
<211>  22
<212>  PRT
<213>  Homo sapiens

<400>  132

Phe Asp Ser Gln Thr Lys Ser Ile Phe Glu Gln Glu Thr Asn Asn Asn 
1               5                   10                  15      


Asn Ser Ser Phe Tyr Thr 
            20          


<210>  133
<211>  80
<212>  PRT
<213>  Homo sapiens

<400>  133

His Lys Asp Glu Val Ile Lys Glu Val Gln Glu Phe Tyr Lys Asp Thr 
1               5                   10                  15      


Tyr Asn Lys Leu Lys Thr Lys Asp Glu Pro Gln Arg Glu Thr Leu Lys 
            20                  25                  30          


Ala Ile His Tyr Ala Leu Asn Cys Cys Gly Leu Ala Gly Gly Val Glu 
        35                  40                  45              


Gln Phe Ile Ser Asp Ile Cys Pro Lys Lys Asp Val Leu Glu Thr Phe 
    50                  55                  60                  


Thr Val Lys Ser Cys Pro Asp Ala Ile Lys Glu Val Phe Asp Asn Lys 
65                  70                  75                  80  


<210>  134
<211>  21
<212>  PRT
<213>  Homo sapiens

<400>  134

Leu Leu Ile His Asn Asn Phe Gly Val Leu Phe His Asn Leu Pro Ser 
1               5                   10                  15      


Leu Thr Leu Gly Asn 
            20      


<210>  135
<211>  78
<212>  PRT
<213>  Homo sapiens

<400>  135

Phe Val Tyr Glu Gln Lys Leu Asn Glu Tyr Val Ala Lys Gly Leu Thr 
1               5                   10                  15      


Asp Ser Ile His Arg Tyr His Ser Asp Asn Ser Thr Lys Ala Ala Trp 
            20                  25                  30          


Asp Ser Ile Gln Ser Phe Leu Gln Cys Cys Gly Ile Asn Gly Thr Ser 
        35                  40                  45              


Asp Trp Thr Ser Gly Pro Pro Ala Ser Cys Pro Ser Asp Arg Lys Val 
    50                  55                  60                  


Glu Gly Cys Tyr Ala Lys Ala Arg Leu Trp Phe His Ser Asn 
65                  70                  75              


<210>  136
<211>  25
<212>  PRT
<213>  Homo sapiens

<400>  136

Thr Tyr Phe Gly Ala His Phe Ala Val Ile Arg Arg Ala Ser Leu Glu 
1               5                   10                  15      


Lys Asn Pro Tyr Gln Ala Val His Gln 
            20                  25  


<210>  137
<211>  94
<212>  PRT
<213>  Homo sapiens

<400>  137

Phe Trp Arg Leu His Ser Pro Thr Gln Val Glu Asp Ala Met Leu Asp 
1               5                   10                  15      


Thr Tyr Asp Leu Val Tyr Glu Gln Ala Met Lys Gly Thr Ser His Val 
            20                  25                  30          


Arg Arg Gln Glu Leu Ala Ala Ile Gln Asp Val Phe Leu Cys Cys Gly 
        35                  40                  45              


Lys Lys Ser Pro Phe Ser Arg Leu Gly Ser Thr Glu Ala Asp Leu Cys 
    50                  55                  60                  


Gln Gly Glu Glu Ala Ala Arg Glu Asp Cys Leu Gln Gly Ile Arg Ser 
65                  70                  75                  80  


Phe Leu Arg Thr His Gln Gln Val Ala Ser Ser Leu Thr Ser 
                85                  90                  


<210>  138
<211>  24
<212>  PRT
<213>  Homo sapiens

<400>  138

Gly Val Trp Ile Leu Ala Asp Lys Ser Ser Phe Ile Ser Val Leu Gln 
1               5                   10                  15      


Thr Ser Ser Ser Ser Leu Arg Met 
            20                  


<210>  139
<211>  120
<212>  PRT
<213>  Homo sapiens

<400>  139

Phe Asn Met Gly Lys Leu Lys Gln Glu Met Gly Gly Ile Val Thr Glu 
1               5                   10                  15      


Leu Ile Arg Asp Tyr Asn Ser Ser Arg Glu Asp Ser Leu Gln Asp Ala 
            20                  25                  30          


Trp Asp Tyr Val Gln Ala Gln Val Lys Cys Cys Gly Trp Val Ser Phe 
        35                  40                  45              


Tyr Asn Trp Thr Asp Asn Ala Glu Leu Met Asn Arg Pro Glu Val Thr 
    50                  55                  60                  


Tyr Pro Cys Ser Cys Glu Val Lys Gly Glu Glu Asp Asn Ser Leu Ser 
65                  70                  75                  80  


Val Arg Lys Gly Phe Cys Glu Ala Pro Gly Asn Arg Thr Gln Ser Gly 
                85                  90                  95      


Asn His Pro Glu Asp Trp Pro Val Tyr Gln Glu Gly Cys Met Glu Lys 
            100                 105                 110         


Val Gln Ala Trp Leu Gln Glu Asn 
        115                 120 


<210>  140
<211>  20
<212>  PRT
<213>  Homo sapiens

<400>  140

Ala Gln Leu Val Leu Ser Gln Thr Ile Ile Gln Gly Ala Thr Pro Gly 
1               5                   10                  15      


Ser Leu Leu Pro 
            20  


<210>  141
<211>  96
<212>  PRT
<213>  Homo sapiens

<400>  141

Phe Arg Asp Lys Val Met Ser Glu Phe Asn Asn Asn Phe Arg Gln Gln 
1               5                   10                  15      


Met Glu Asn Tyr Pro Lys Asn Asn His Thr Ala Ser Ile Leu Asp Arg 
            20                  25                  30          


Met Gln Ala Asp Phe Lys Cys Cys Gly Ala Ala Asn Tyr Thr Asp Trp 
        35                  40                  45              


Glu Lys Ile Pro Ser Met Ser Lys Asn Arg Val Pro Asp Ser Cys Cys 
    50                  55                  60                  


Ile Asn Val Thr Val Gly Cys Gly Ile Asn Phe Asn Glu Lys Ala Ile 
65                  70                  75                  80  


His Lys Glu Gly Cys Val Glu Lys Ile Gly Gly Trp Leu Arg Lys Asn 
                85                  90                  95      


<210>  142
<211>  21
<212>  PRT
<213>  Homo sapiens

<400>  142

Thr Leu Ala Leu Lys Ser Asp Tyr Ile Ser Leu Leu Ala Ser Gly Thr 
1               5                   10                  15      


Tyr Leu Ala Thr Ala 
            20      


<210>  143
<211>  110
<212>  PRT
<213>  Homo sapiens

<400>  143

Tyr Ala Tyr Tyr Gln Gln Leu Asn Thr Glu Leu Lys Glu Asn Leu Lys 
1               5                   10                  15      


Asp Thr Met Thr Lys Arg Tyr His Gln Pro Gly His Glu Ala Val Thr 
            20                  25                  30          


Ser Ala Val Asp Gln Leu Gln Gln Glu Phe His Cys Cys Gly Ser Asn 
        35                  40                  45              


Asn Ser Gln Asp Trp Arg Asp Ser Glu Trp Ile Arg Ser Gln Glu Ala 
    50                  55                  60                  


Gly Gly Arg Val Val Pro Asp Ser Cys Cys Lys Thr Val Val Ala Leu 
65                  70                  75                  80  


Cys Gly Gln Arg Asp His Ala Ser Asn Ile Tyr Lys Val Glu Gly Gly 
                85                  90                  95      


Cys Ile Thr Lys Leu Glu Thr Phe Ile Gln Glu His Leu Arg 
            100                 105                 110 


<210>  144
<211>  27
<212>  PRT
<213>  Homo sapiens

<400>  144

Gly Ile Trp Ile Leu Ile Asp Lys Thr Ser Phe Val Ser Phe Val Gly 
1               5                   10                  15      


Leu Ala Phe Val Pro Leu Gln Ile Trp Ser Lys 
            20                  25          


<210>  145
<211>  133
<212>  PRT
<213>  Homo sapiens

<400>  145

Ser Thr Gln Arg Ala Gln Leu Glu Arg Ser Leu Arg Asp Val Val Glu 
1               5                   10                  15      


Lys Thr Ile Gln Lys Tyr Gly Thr Asn Pro Glu Glu Thr Ala Ala Glu 
            20                  25                  30          


Glu Ser Trp Asp Tyr Val Gln Phe Gln Leu Arg Cys Cys Gly Trp His 
        35                  40                  45              


Tyr Pro Gln Asp Trp Phe Gln Val Leu Ile Leu Arg Gly Asn Gly Ser 
    50                  55                  60                  


Glu Ala His Arg Val Pro Cys Ser Cys Tyr Asn Leu Ser Ala Thr Asn 
65                  70                  75                  80  


Asp Ser Thr Ile Leu Asp Lys Val Ile Leu Pro Gln Leu Ser Arg Leu 
                85                  90                  95      


Gly His Leu Ala Arg Ser Arg His Ser Ala Asp Ile Cys Ala Val Pro 
            100                 105                 110         


Ala Glu Ser His Ile Tyr Arg Glu Gly Cys Ala Gln Gly Leu Gln Lys 
        115                 120                 125             


Trp Leu His Asn Asn 
    130             


<210>  146
<211>  379
<212>  PRT
<213>  Homo sapiens

<400>  146

Met Val Cys Phe Arg Leu Phe Pro Val Pro Gly Ser Gly Leu Val Leu 
1               5                   10                  15      


Val Cys Leu Val Leu Gly Ala Val Arg Ser Tyr Ala Leu Glu Leu Asn 
            20                  25                  30          


Leu Thr Asp Ser Glu Asn Ala Thr Cys Leu Tyr Ala Lys Trp Gln Met 
        35                  40                  45              


Asn Phe Thr Val Arg Tyr Glu Thr Thr Asn Lys Thr Tyr Lys Thr Val 
    50                  55                  60                  


Thr Ile Ser Asp His Gly Thr Val Thr Tyr Asn Gly Ser Ile Cys Gly 
65                  70                  75                  80  


Asp Asp Gln Asn Gly Pro Lys Ile Ala Val Gln Phe Gly Pro Gly Phe 
                85                  90                  95      


Ser Trp Ile Ala Asn Phe Thr Lys Ala Ala Ser Thr Tyr Ser Ile Asp 
            100                 105                 110         


Ser Val Ser Phe Ser Tyr Asn Thr Gly Asp Asn Thr Thr Phe Pro Asp 
        115                 120                 125             


Ala Glu Asp Lys Gly Ile Leu Thr Val Asp Glu Leu Leu Ala Ile Arg 
    130                 135                 140                 


Ile Pro Leu Asn Asp Leu Phe Arg Cys Asn Ser Leu Ser Thr Leu Glu 
145                 150                 155                 160 


Lys Asn Asp Val Val Gln His Tyr Trp Asp Val Leu Val Gln Ala Phe 
                165                 170                 175     


Val Gln Asn Gly Thr Val Ser Thr Asn Glu Phe Leu Cys Asp Lys Asp 
            180                 185                 190         


Lys Thr Ser Thr Val Ala Pro Thr Ile His Thr Thr Val Pro Ser Pro 
        195                 200                 205             


Thr Thr Thr Pro Thr Pro Lys Glu Lys Pro Glu Ala Gly Thr Tyr Ser 
    210                 215                 220                 


Val Asn Asn Gly Asn Asp Thr Cys Leu Leu Ala Thr Met Gly Leu Gln 
225                 230                 235                 240 


Leu Asn Ile Thr Gln Asp Lys Val Ala Ser Val Ile Asn Ile Asn Pro 
                245                 250                 255     


Asn Thr Thr His Ser Thr Gly Ser Cys Arg Ser His Thr Ala Leu Leu 
            260                 265                 270         


Arg Leu Asn Ser Ser Thr Ile Lys Tyr Leu Asp Phe Val Phe Ala Val 
        275                 280                 285             


Lys Asn Glu Asn Arg Phe Tyr Leu Lys Glu Val Asn Ile Ser Met Tyr 
    290                 295                 300                 


Leu Val Asn Gly Ser Val Phe Ser Ile Ala Asn Asn Asn Leu Ser Tyr 
305                 310                 315                 320 


Trp Asp Ala Pro Leu Gly Ser Ser Tyr Met Cys Asn Lys Glu Gln Thr 
                325                 330                 335     


Val Ser Val Ser Gly Ala Phe Gln Ile Asn Thr Phe Asp Leu Arg Val 
            340                 345                 350         


Gln Pro Phe Asn Val Thr Gln Gly Lys Tyr Ser Thr Ala Gln Glu Cys 
        355                 360                 365             


Ser Leu Asp Asp Asp Thr Ile Leu Ile Pro Ile 
    370                 375                 


<210>  147
<211>  21
<212>  PRT
<213>  Homo sapiens

<400>  147

Phe Val Phe Asn Phe Val Phe Trp Leu Ala Gly Gly Val Ile Leu Gly 
1               5                   10                  15      


Val Ala Leu Trp Leu 
            20      


<210>  148
<211>  19
<212>  PRT
<213>  Homo sapiens

<400>  148

Val Gly Ile Tyr Ile Leu Ile Ala Val Gly Ala Val Met Met Phe Val 
1               5                   10                  15      


Gly Phe Leu 
            


<210>  149
<211>  21
<212>  PRT
<213>  Homo sapiens

<400>  149

Phe Thr Cys Leu Val Ile Leu Phe Ala Cys Glu Val Ala Ala Gly Ile 
1               5                   10                  15      


Trp Gly Phe Val Asn 
            20      


<210>  150
<211>  25
<212>  PRT
<213>  Homo sapiens

<400>  150

Leu Tyr Leu Ile Gly Ile Ala Ala Ile Val Val Ala Val Ile Met Ile 
1               5                   10                  15      


Phe Glu Met Ile Leu Ser Met Val Leu 
            20                  25  


<210>  151
<211>  19
<212>  PRT
<213>  Homo sapiens

<400>  151

Phe Asn Phe Ile Phe Trp Leu Ala Gly Ile Ala Val Leu Ala Ile Gly 
1               5                   10                  15      


Leu Trp Leu 
            


<210>  152
<211>  19
<212>  PRT
<213>  Homo sapiens

<400>  152

Val Tyr Ile Leu Ile Gly Ala Gly Ala Leu Met Met Leu Val Gly Phe 
1               5                   10                  15      


Leu Gly Gly 
            


<210>  153
<211>  18
<212>  PRT
<213>  Homo sapiens

<400>  153

Leu Phe Phe Gly Phe Leu Leu Val Ile Phe Ala Ile Glu Ile Ala Ala 
1               5                   10                  15      


Ala Ile 
        


<210>  154
<211>  27
<212>  PRT
<213>  Homo sapiens

<400>  154

Ile Ile Gly Ala Val Gly Ile Gly Ile Ala Val Val Met Ile Phe Gly 
1               5                   10                  15      


Met Ile Phe Ser Met Ile Leu Cys Cys Ala Ile 
            20                  25          


<210>  155
<211>  21
<212>  PRT
<213>  Homo sapiens

<400>  155

Leu Phe Phe Phe Asn Leu Leu Phe Trp Ile Cys Gly Cys Cys Ile Leu 
1               5                   10                  15      


Gly Phe Gly Ile Tyr 
            20      


<210>  156
<211>  17
<212>  PRT
<213>  Homo sapiens

<400>  156

Asn Val Phe Val Ile Val Gly Ser Ile Ile Met Val Val Ala Phe Leu 
1               5                   10                  15      


Gly 
    


<210>  157
<211>  27
<212>  PRT
<213>  Homo sapiens

<400>  157

Cys Leu Leu Met Ser Phe Phe Ile Leu Leu Leu Ile Ile Leu Leu Ala 
1               5                   10                  15      


Glu Val Thr Leu Ala Ile Leu Leu Phe Val Tyr 
            20                  25          


<210>  158
<211>  21
<212>  PRT
<213>  Homo sapiens

<400>  158

Phe Leu Tyr Ile Gly Ile Ile Thr Ile Cys Val Cys Val Ile Glu Val 
1               5                   10                  15      


Leu Gly Met Ser Phe 
            20      


<210>  159
<211>  23
<212>  PRT
<213>  Homo sapiens

<400>  159

Cys Gln Met Leu Val Thr Cys Phe Phe Ile Leu Leu Leu Gly Leu Ser 
1               5                   10                  15      


Val Ala Thr Met Val Thr Leu 
            20              


<210>  160
<211>  21
<212>  PRT
<213>  Homo sapiens

<400>  160

Trp Ala Phe Ser Ala Gly Leu Ser Leu Val Gly Leu Leu Thr Leu Gly 
1               5                   10                  15      


Ala Val Leu Ser Ala 
            20      


<210>  161
<211>  22
<212>  PRT
<213>  Homo sapiens

<400>  161

Gly Leu Met Ala Gly Gly Phe Leu Cys Phe Ser Leu Ala Phe Cys Ala 
1               5                   10                  15      


Gln Val Gln Val Val Phe 
            20          


<210>  162
<211>  20
<212>  PRT
<213>  Homo sapiens

<400>  162

Ile Gly Leu Ala Leu Thr Val Ser Ala Leu Leu Phe Ser Ser Phe Leu 
1               5                   10                  15      


Trp Phe Ala Ile 
            20  


<210>  163
<211>  18
<212>  PRT
<213>  Homo sapiens

<400>  163

Leu Phe Leu Phe Asn Leu Ile Phe Phe Ile Leu Gly Ala Val Ile Leu 
1               5                   10                  15      


Gly Phe 
        


<210>  164
<211>  19
<212>  PRT
<213>  Homo sapiens

<400>  164

Met Gly Ala Tyr Val Phe Ile Gly Val Gly Ala Val Thr Met Leu Met 
1               5                   10                  15      


Gly Phe Leu 
            


<210>  165
<211>  26
<212>  PRT
<213>  Homo sapiens

<400>  165

Cys Leu Leu Gly Leu Tyr Phe Ala Phe Leu Leu Leu Ile Leu Ile Ala 
1               5                   10                  15      


Gln Val Thr Ala Gly Ala Leu Phe Tyr Phe 
            20                  25      


<210>  166
<211>  24
<212>  PRT
<213>  Homo sapiens

<400>  166

Glu Lys Val Gln Ala Trp Leu Gln Glu Asn Leu Gly Ile Ile Leu Gly 
1               5                   10                  15      


Val Gly Val Gly Val Ala Ile Ile 
            20                  


<210>  167
<211>  22
<212>  PRT
<213>  Homo sapiens

<400>  167

Phe Leu Leu Tyr Val Leu Leu Leu Ala Phe Cys Ala Cys Ala Val Gly 
1               5                   10                  15      


Leu Ile Ala Val Gly Val 
            20          


<210>  168
<211>  17
<212>  PRT
<213>  Homo sapiens

<400>  168

Val Ile Ile Ala Val Gly Val Phe Leu Phe Leu Val Ala Phe Val Gly 
1               5                   10                  15      


Cys 
    


<210>  169
<211>  25
<212>  PRT
<213>  Homo sapiens

<400>  169

Met Ile Thr Phe Ala Ile Phe Leu Ser Leu Ile Met Leu Val Glu Val 
1               5                   10                  15      


Ala Ala Ala Ile Ala Gly Tyr Val Phe 
            20                  25  


<210>  170
<211>  26
<212>  PRT
<213>  Homo sapiens

<400>  170

Val Leu Val Val Ala Ala Ala Ala Leu Gly Ile Ala Phe Val Glu Val 
1               5                   10                  15      


Leu Gly Ile Val Phe Ala Cys Cys Leu Val 
            20                  25      


<210>  171
<211>  20
<212>  PRT
<213>  Homo sapiens

<400>  171

Phe Thr Tyr Asn Cys Cys Phe Trp Leu Ala Gly Leu Ala Val Met Ala 
1               5                   10                  15      


Val Gly Ile Trp 
            20  


<210>  172
<211>  20
<212>  PRT
<213>  Homo sapiens

<400>  172

Tyr Ile Leu Val Val Ala Gly Thr Val Val Met Val Thr Gly Val Leu 
1               5                   10                  15      


Gly Cys Cys Ala 
            20  


<210>  173
<211>  20
<212>  PRT
<213>  Homo sapiens

<400>  173

Leu Tyr Phe Ile Leu Leu Leu Ile Ile Phe Leu Leu Glu Ile Ile Ala 
1               5                   10                  15      


Gly Ile Leu Ala 
            20  


<210>  174
<211>  20
<212>  PRT
<213>  Homo sapiens

<400>  174

Val Ile Gly Ala Val Gly Ile Gly Ile Ala Cys Val Gln Val Phe Gly 
1               5                   10                  15      


Met Ile Phe Thr 
            20  


<210>  175
<211>  18
<212>  PRT
<213>  Homo sapiens

<400>  175

Leu Phe Val Phe Asn Leu Phe Phe Phe Val Leu Gly Ser Leu Ile Phe 
1               5                   10                  15      


Cys Phe 
        


<210>  176
<211>  20
<212>  PRT
<213>  Homo sapiens

<400>  176

Leu Ala Ile Ser Gly Ile Phe Thr Met Gly Ile Ala Leu Leu Gly Cys 
1               5                   10                  15      


Val Gly Ala Leu 
            20  


<210>  177
<211>  23
<212>  PRT
<213>  Homo sapiens

<400>  177

Leu Leu Gly Leu Tyr Phe Gly Met Leu Leu Leu Leu Phe Ala Thr Gln 
1               5                   10                  15      


Ile Thr Leu Gly Ile Leu Ile 
            20              


<210>  178
<211>  24
<212>  PRT
<213>  Homo sapiens

<400>  178

Leu Ile Ser Ile Val Gly Ile Cys Leu Gly Val Gly Leu Leu Glu Leu 
1               5                   10                  15      


Gly Phe Met Thr Leu Ser Ile Phe 
            20                  


<210>  179
<211>  20
<212>  PRT
<213>  Homo sapiens

<400>  179

Ile Val Gly Ala Gly Leu Ser Gly Leu Ile Ile Val Ile Val Ile Ala 
1               5                   10                  15      


Tyr Val Ile Gly 
            20  


<210>  180
<211>  89
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD81 LEL mutant

<400>  180

Phe Val Asn Lys Asp Gln Ile Ala Lys Asp Val Lys Gln Phe Tyr Asp 
1               5                   10                  15      


Gln Cys Leu Gln Gln Ala Cys Val Asp Asp Asp Ala Asn Asn Ala Lys 
            20                  25                  30          


Ala Cys Val Lys Thr Phe His Glu Thr Leu Asp Cys Cys Gly Ser Ser 
        35                  40                  45              


Thr Leu Thr Ala Leu Thr Thr Cys Val Leu Lys Asn Asn Leu Cys Pro 
    50                  55                  60                  


Ser Gly Ser Asn Ile Ile Ser Asn Leu Phe Lys Glu Asp Cys His Gln 
65                  70                  75                  80  


Lys Ile Asp Asp Leu Phe Ser Gly Lys 
                85                  


<210>  181
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Binding sequence

<400>  181

Pro His His Trp Arg Phe Pro Lys Ala 
1               5                   


<210>  182
<211>  25
<212>  PRT
<213>  Homo sapiens

<400>  182

Leu Arg Phe Asp Ser Gln Thr Lys Ser Ile Phe Glu Gln Glu Thr Asn 
1               5                   10                  15      


Asn Asn Asn Ser Ser Phe Tyr Thr Gly 
            20                  25  


<210>  183
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Motif


<220>
<221>  MISC_FEATURE
<222>  (2)..(3)
<223>  X can be any amino acid

<400>  183

Pro Xaa Xaa Cys 
1               


<210>  184
<211>  237
<212>  PRT
<213>  Homo sapiens

<400>  184

Met Ala Gly Val Ser Ala Cys Ile Lys Tyr Ser Met Phe Thr Phe Asn 
1               5                   10                  15      


Phe Leu Phe Trp Leu Cys Gly Ile Leu Ile Leu Ala Leu Ala Ile Trp 
            20                  25                  30          


Val Arg Val Ser Asn Asp Ser Gln Ala Ile Phe Gly Ser Glu Asp Val 
        35                  40                  45              


Gly Ser Ser Ser Tyr Val Ala Val Asp Ile Leu Ile Ala Val Gly Ala 
    50                  55                  60                  


Ile Ile Met Ile Leu Gly Phe Leu Gly Cys Cys Gly Ala Ile Lys Glu 
65                  70                  75                  80  


Ser Arg Cys Met Leu Leu Leu Phe Phe Ile Gly Leu Leu Leu Ile Leu 
                85                  90                  95      


Leu Leu Gln Val Ala Thr Gly Ile Leu Gly Ala Val Phe Lys Ser Lys 
            100                 105                 110         


Ser Asp Arg Ile Val Asn Glu Thr Leu Tyr Glu Asn Thr Lys Leu Leu 
        115                 120                 125             


Ser Ala Thr Gly Glu Ser Glu Lys Gln Phe Gln Glu Ala Ile Ile Val 
    130                 135                 140                 


Phe Gln Glu Glu Phe Lys Cys Cys Gly Leu Val Asn Gly Ala Ala Asp 
145                 150                 155                 160 


Trp Gly Asn Asn Phe Gln His Tyr Pro Glu Leu Cys Ala Cys Leu Asp 
                165                 170                 175     


Lys Gln Arg Pro Cys Gln Ser Tyr Asn Gly Lys Gln Val Tyr Lys Glu 
            180                 185                 190         


Thr Cys Ile Ser Phe Ile Lys Asp Phe Leu Ala Lys Asn Leu Ile Ile 
        195                 200                 205             


Val Ile Gly Ile Ser Phe Gly Leu Ala Val Ile Glu Ile Leu Gly Leu 
    210                 215                 220                 


Val Phe Ser Met Val Leu Tyr Cys Gln Ile Gly Asn Lys 
225                 230                 235         


<210>  185
<211>  147
<212>  PRT
<213>  Homo sapiens

<400>  185

Met His Tyr Tyr Arg Tyr Ser Asn Ala Lys Val Ser Cys Trp Tyr Lys 
1               5                   10                  15      


Tyr Leu Leu Phe Ser Tyr Asn Ile Ile Phe Trp Asn Gln Cys Cys Gly 
            20                  25                  30          


Ala Tyr Gly Pro Glu Asp Trp Asp Leu Asn Val Tyr Phe Asn Cys Ser 
        35                  40                  45              


Gly Ala Ser Tyr Ser Arg Glu Lys Cys Gly Val Pro Phe Ser Cys Cys 
    50                  55                  60                  


Val Pro Asp Pro Ala Gln Lys Val Val Asn Thr Gln Cys Gly Tyr Asp 
65                  70                  75                  80  


Val Arg Ile Gln Leu Lys Ser Lys Trp Asp Glu Ser Ile Phe Thr Lys 
                85                  90                  95      


Gly Cys Ile Gln Ala Leu Glu Ser Trp Leu Pro Arg Asn Ile Tyr Ile 
            100                 105                 110         


Val Ala Gly Val Phe Ile Ala Ile Ser Leu Leu Gln Ile Phe Gly Ile 
        115                 120                 125             


Phe Leu Ala Arg Thr Leu Ile Ser Asp Ile Glu Ala Val Lys Ala Gly 
    130                 135                 140                 


His His Phe 
145         


<210>  186
<211>  249
<212>  PRT
<213>  Homo sapiens

<400>  186

Met Ala Ser Arg Arg Met Glu Thr Lys Pro Val Ile Thr Cys Leu Lys 
1               5                   10                  15      


Thr Leu Leu Ile Ile Tyr Ser Phe Val Phe Trp Ile Thr Gly Val Ile 
            20                  25                  30          


Leu Leu Ala Val Gly Val Trp Gly Lys Leu Thr Leu Gly Thr Tyr Ile 
        35                  40                  45              


Ser Leu Ile Ala Glu Asn Ser Thr Asn Ala Pro Tyr Val Leu Ile Gly 
    50                  55                  60                  


Thr Gly Thr Thr Ile Val Val Phe Gly Leu Phe Gly Cys Phe Ala Thr 
65                  70                  75                  80  


Cys Arg Gly Ser Pro Trp Met Leu Lys Leu Tyr Ala Met Phe Leu Ser 
                85                  90                  95      


Leu Val Phe Leu Ala Glu Leu Val Ala Gly Ile Ser Gly Phe Val Phe 
            100                 105                 110         


Arg His Glu Ile Lys Asp Thr Phe Leu Arg Thr Tyr Thr Asp Ala Met 
        115                 120                 125             


Gln Thr Tyr Asn Gly Asn Asp Glu Arg Ser Arg Ala Val Asp His Val 
    130                 135                 140                 


Gln Arg Ser Leu Ser Cys Cys Gly Val Gln Asn Tyr Thr Asn Trp Ser 
145                 150                 155                 160 


Thr Ser Pro Tyr Phe Leu Glu His Gly Ile Pro Pro Ser Cys Cys Met 
                165                 170                 175     


Asn Glu Thr Asp Cys Asn Pro Gln Asp Leu His Asn Leu Thr Val Ala 
            180                 185                 190         


Ala Thr Lys Val Asn Gln Lys Gly Cys Tyr Asp Leu Val Thr Ser Phe 
        195                 200                 205             


Met Glu Thr Asn Met Gly Ile Ile Ala Gly Val Ala Phe Gly Ile Ala 
    210                 215                 220                 


Phe Ser Gln Leu Ile Gly Met Leu Leu Ala Cys Cys Leu Ser Arg Phe 
225                 230                 235                 240 


Ile Thr Ala Asn Gln Tyr Glu Met Val 
                245                 


<210>  187
<211>  1032
<212>  PRT
<213>  Homo sapiens

<400>  187

Met Ala Trp Glu Ala Arg Arg Glu Pro Gly Pro Arg Arg Ala Ala Val 
1               5                   10                  15      


Arg Glu Thr Val Met Leu Leu Leu Cys Leu Gly Val Pro Thr Gly Arg 
            20                  25                  30          


Pro Tyr Asn Val Asp Thr Glu Ser Ala Leu Leu Tyr Gln Gly Pro His 
        35                  40                  45              


Asn Thr Leu Phe Gly Tyr Ser Val Val Leu His Ser His Gly Ala Asn 
    50                  55                  60                  


Arg Trp Leu Leu Val Gly Ala Pro Thr Ala Asn Trp Leu Ala Asn Ala 
65                  70                  75                  80  


Ser Val Ile Asn Pro Gly Ala Ile Tyr Arg Cys Arg Ile Gly Lys Asn 
                85                  90                  95      


Pro Gly Gln Thr Cys Glu Gln Leu Gln Leu Gly Ser Pro Asn Gly Glu 
            100                 105                 110         


Pro Cys Gly Lys Thr Cys Leu Glu Glu Arg Asp Asn Gln Trp Leu Gly 
        115                 120                 125             


Val Thr Leu Ser Arg Gln Pro Gly Glu Asn Gly Ser Ile Val Thr Cys 
    130                 135                 140                 


Gly His Arg Trp Lys Asn Ile Phe Tyr Ile Lys Asn Glu Asn Lys Leu 
145                 150                 155                 160 


Pro Thr Gly Gly Cys Tyr Gly Val Pro Pro Asp Leu Arg Thr Glu Leu 
                165                 170                 175     


Ser Lys Arg Ile Ala Pro Cys Tyr Gln Asp Tyr Val Lys Lys Phe Gly 
            180                 185                 190         


Glu Asn Phe Ala Ser Cys Gln Ala Gly Ile Ser Ser Phe Tyr Thr Lys 
        195                 200                 205             


Asp Leu Ile Val Met Gly Ala Pro Gly Ser Ser Tyr Trp Thr Gly Ser 
    210                 215                 220                 


Leu Phe Val Tyr Asn Ile Thr Thr Asn Lys Tyr Lys Ala Phe Leu Asp 
225                 230                 235                 240 


Lys Gln Asn Gln Val Lys Phe Gly Ser Tyr Leu Gly Tyr Ser Val Gly 
                245                 250                 255     


Ala Gly His Phe Arg Ser Gln His Thr Thr Glu Val Val Gly Gly Ala 
            260                 265                 270         


Pro Gln His Glu Gln Ile Gly Lys Ala Tyr Ile Phe Ser Ile Asp Glu 
        275                 280                 285             


Lys Glu Leu Asn Ile Leu His Glu Met Lys Gly Lys Lys Leu Gly Ser 
    290                 295                 300                 


Tyr Phe Gly Ala Ser Val Cys Ala Val Asp Leu Asn Ala Asp Gly Phe 
305                 310                 315                 320 


Ser Asp Leu Leu Val Gly Ala Pro Met Gln Ser Thr Ile Arg Glu Glu 
                325                 330                 335     


Gly Arg Val Phe Val Tyr Ile Asn Ser Gly Ser Gly Ala Val Met Asn 
            340                 345                 350         


Ala Met Glu Thr Asn Leu Val Gly Ser Asp Lys Tyr Ala Ala Arg Phe 
        355                 360                 365             


Gly Glu Ser Ile Val Asn Leu Gly Asp Ile Asp Asn Asp Gly Phe Glu 
    370                 375                 380                 


Asp Val Ala Ile Gly Ala Pro Gln Glu Asp Asp Leu Gln Gly Ala Ile 
385                 390                 395                 400 


Tyr Ile Tyr Asn Gly Arg Ala Asp Gly Ile Ser Ser Thr Phe Ser Gln 
                405                 410                 415     


Arg Ile Glu Gly Leu Gln Ile Ser Lys Ser Leu Ser Met Phe Gly Gln 
            420                 425                 430         


Ser Ile Ser Gly Gln Ile Asp Ala Asp Asn Asn Gly Tyr Val Asp Val 
        435                 440                 445             


Ala Val Gly Ala Phe Arg Ser Asp Ser Ala Val Leu Leu Arg Thr Arg 
    450                 455                 460                 


Pro Val Val Ile Val Asp Ala Ser Leu Ser His Pro Glu Ser Val Asn 
465                 470                 475                 480 


Arg Thr Lys Phe Asp Cys Val Glu Asn Gly Trp Pro Ser Val Cys Ile 
                485                 490                 495     


Asp Leu Thr Leu Cys Phe Ser Tyr Lys Gly Lys Glu Val Pro Gly Tyr 
            500                 505                 510         


Ile Val Leu Phe Tyr Asn Met Ser Leu Asp Val Asn Arg Lys Ala Glu 
        515                 520                 525             


Ser Pro Pro Arg Phe Tyr Phe Ser Ser Asn Gly Thr Ser Asp Val Ile 
    530                 535                 540                 


Thr Gly Ser Ile Gln Val Ser Ser Arg Glu Ala Asn Cys Arg Thr His 
545                 550                 555                 560 


Gln Ala Phe Met Arg Lys Asp Val Arg Asp Ile Leu Thr Pro Ile Gln 
                565                 570                 575     


Ile Glu Ala Ala Tyr His Leu Gly Pro His Val Ile Ser Lys Arg Ser 
            580                 585                 590         


Thr Glu Glu Phe Pro Pro Leu Gln Pro Ile Leu Gln Gln Lys Lys Glu 
        595                 600                 605             


Lys Asp Ile Met Lys Lys Thr Ile Asn Phe Ala Arg Phe Cys Ala His 
    610                 615                 620                 


Glu Asn Cys Ser Ala Asp Leu Gln Val Ser Ala Lys Ile Gly Phe Leu 
625                 630                 635                 640 


Lys Pro His Glu Asn Lys Thr Tyr Leu Ala Val Gly Ser Met Lys Thr 
                645                 650                 655     


Leu Met Leu Asn Val Ser Leu Phe Asn Ala Gly Asp Asp Ala Tyr Glu 
            660                 665                 670         


Thr Thr Leu His Val Lys Leu Pro Val Gly Leu Tyr Phe Ile Lys Ile 
        675                 680                 685             


Leu Glu Leu Glu Glu Lys Gln Ile Asn Cys Glu Val Thr Asp Asn Ser 
    690                 695                 700                 


Gly Val Val Gln Leu Asp Cys Ser Ile Gly Tyr Ile Tyr Val Asp His 
705                 710                 715                 720 


Leu Ser Arg Ile Asp Ile Ser Phe Leu Leu Asp Val Ser Ser Leu Ser 
                725                 730                 735     


Arg Ala Glu Glu Asp Leu Ser Ile Thr Val His Ala Thr Cys Glu Asn 
            740                 745                 750         


Glu Glu Glu Met Asp Asn Leu Lys His Ser Arg Val Thr Val Ala Ile 
        755                 760                 765             


Pro Leu Lys Tyr Glu Val Lys Leu Thr Val His Gly Phe Val Asn Pro 
    770                 775                 780                 


Thr Ser Phe Val Tyr Gly Ser Asn Asp Glu Asn Glu Pro Glu Thr Cys 
785                 790                 795                 800 


Met Val Glu Lys Met Asn Leu Thr Phe His Val Ile Asn Thr Gly Asn 
                805                 810                 815     


Ser Met Ala Pro Asn Val Ser Val Glu Ile Met Val Pro Asn Ser Phe 
            820                 825                 830         


Ser Pro Gln Thr Asp Lys Leu Phe Asn Ile Leu Asp Val Gln Thr Thr 
        835                 840                 845             


Thr Gly Glu Cys His Phe Glu Asn Tyr Gln Arg Val Cys Ala Leu Glu 
    850                 855                 860                 


Gln Gln Lys Ser Ala Met Gln Thr Leu Lys Gly Ile Val Arg Phe Leu 
865                 870                 875                 880 


Ser Lys Thr Asp Lys Arg Leu Leu Tyr Cys Ile Lys Ala Asp Pro His 
                885                 890                 895     


Cys Leu Asn Phe Leu Cys Asn Phe Gly Lys Met Glu Ser Gly Lys Glu 
            900                 905                 910         


Ala Ser Val His Ile Gln Leu Glu Gly Arg Pro Ser Ile Leu Glu Met 
        915                 920                 925             


Asp Glu Thr Ser Ala Leu Lys Phe Glu Ile Arg Ala Thr Gly Phe Pro 
    930                 935                 940                 


Glu Pro Asn Pro Arg Val Ile Glu Leu Asn Lys Asp Glu Asn Val Ala 
945                 950                 955                 960 


His Val Leu Leu Glu Gly Leu His His Gln Arg Pro Lys Arg Tyr Phe 
                965                 970                 975     


Thr Ile Val Ile Ile Ser Ser Ser Leu Leu Leu Gly Leu Ile Val Leu 
            980                 985                 990         


Leu Leu Ile Ser Tyr Val Met Trp  Lys Ala Gly Phe Phe  Lys Arg Gln 
        995                 1000                 1005             


Tyr Lys  Ser Ile Leu Gln Glu  Glu Asn Arg Arg Asp  Ser Trp Ser 
    1010                 1015                 1020             


Tyr Ile  Asn Ser Lys Ser Asn  Asp Asp 
    1025                 1030         


<210>  188
<211>  691
<212>  PRT
<213>  Homo sapiens

<400>  188

Met Thr Pro Gln Glu Ile Ala Val Asn Leu Arg Pro Gly Asp Lys Thr 
1               5                   10                  15      


Thr Phe Gln Leu Gln Val Arg Gln Val Glu Asp Tyr Pro Val Asp Leu 
            20                  25                  30          


Tyr Tyr Leu Met Asp Leu Ser Leu Ser Met Lys Asp Asp Leu Asp Asn 
        35                  40                  45              


Ile Arg Ser Leu Gly Thr Lys Leu Ala Glu Glu Met Arg Lys Leu Thr 
    50                  55                  60                  


Ser Asn Phe Arg Leu Gly Phe Gly Ser Phe Val Asp Lys Asp Ile Ser 
65                  70                  75                  80  


Pro Phe Ser Tyr Thr Ala Pro Arg Tyr Gln Thr Asn Pro Cys Ile Gly 
                85                  90                  95      


Tyr Lys Leu Phe Pro Asn Cys Val Pro Ser Phe Gly Phe Arg His Leu 
            100                 105                 110         


Leu Pro Leu Thr Asp Arg Val Asp Ser Phe Asn Glu Glu Val Arg Lys 
        115                 120                 125             


Gln Arg Val Ser Arg Asn Arg Asp Ala Pro Glu Gly Gly Phe Asp Ala 
    130                 135                 140                 


Val Leu Gln Ala Ala Val Cys Lys Glu Lys Ile Gly Trp Arg Lys Asp 
145                 150                 155                 160 


Ala Leu His Leu Leu Val Phe Thr Thr Asp Asp Val Pro His Ile Ala 
                165                 170                 175     


Leu Asp Gly Lys Leu Gly Gly Leu Val Gln Pro His Asp Gly Gln Cys 
            180                 185                 190         


His Leu Asn Glu Ala Asn Glu Tyr Thr Ala Ser Asn Gln Met Asp Tyr 
        195                 200                 205             


Pro Ser Leu Ala Leu Leu Gly Glu Lys Leu Ala Glu Asn Asn Ile Asn 
    210                 215                 220                 


Leu Ile Phe Ala Val Thr Lys Asn His Tyr Met Leu Tyr Lys Asn Phe 
225                 230                 235                 240 


Thr Ala Leu Ile Pro Gly Thr Thr Val Glu Ile Leu Asp Gly Asp Ser 
                245                 250                 255     


Lys Asn Ile Ile Gln Leu Ile Ile Asn Ala Tyr Asn Ser Ile Arg Ser 
            260                 265                 270         


Lys Val Glu Leu Ser Val Trp Asp Gln Pro Glu Asp Leu Asn Leu Phe 
        275                 280                 285             


Phe Thr Ala Thr Cys Gln Asp Gly Val Ser Tyr Pro Gly Gln Arg Lys 
    290                 295                 300                 


Cys Glu Gly Leu Lys Ile Gly Asp Thr Ala Ser Phe Glu Val Ser Leu 
305                 310                 315                 320 


Glu Ala Arg Ser Cys Pro Ser Arg His Thr Glu His Val Phe Ala Leu 
                325                 330                 335     


Arg Pro Val Gly Phe Arg Asp Ser Leu Glu Val Gly Val Thr Tyr Asn 
            340                 345                 350         


Cys Thr Cys Gly Cys Ser Val Gly Leu Glu Pro Asn Ser Ala Arg Cys 
        355                 360                 365             


Asn Gly Ser Gly Thr Tyr Val Cys Gly Leu Cys Glu Cys Ser Pro Gly 
    370                 375                 380                 


Tyr Leu Gly Thr Arg Cys Glu Cys Gln Asp Gly Glu Asn Gln Ser Val 
385                 390                 395                 400 


Tyr Gln Asn Leu Cys Arg Glu Ala Glu Gly Lys Pro Leu Cys Ser Gly 
                405                 410                 415     


Arg Gly Asp Cys Ser Cys Asn Gln Cys Ser Cys Phe Glu Ser Glu Phe 
            420                 425                 430         


Gly Lys Ile Tyr Gly Pro Phe Cys Glu Cys Asp Asn Phe Ser Cys Ala 
        435                 440                 445             


Arg Asn Lys Gly Val Leu Cys Ser Gly His Gly Glu Cys His Cys Gly 
    450                 455                 460                 


Glu Cys Lys Cys His Ala Gly Tyr Ile Gly Asp Asn Cys Asn Cys Ser 
465                 470                 475                 480 


Thr Asp Ile Ser Thr Cys Arg Gly Arg Asp Gly Gln Ile Cys Ser Glu 
                485                 490                 495     


Arg Gly His Cys Leu Cys Gly Gln Cys Gln Cys Thr Glu Pro Gly Ala 
            500                 505                 510         


Phe Gly Glu Met Cys Glu Lys Cys Pro Thr Cys Pro Asp Ala Cys Ser 
        515                 520                 525             


Thr Lys Arg Asp Cys Val Glu Cys Leu Leu Leu His Ser Gly Lys Pro 
    530                 535                 540                 


Asp Asn Gln Thr Cys His Ser Leu Cys Arg Asp Glu Val Ile Thr Trp 
545                 550                 555                 560 


Val Asp Thr Ile Val Lys Asp Asp Gln Glu Ala Val Leu Cys Phe Tyr 
                565                 570                 575     


Lys Thr Ala Lys Asp Cys Val Met Met Phe Thr Tyr Val Glu Leu Pro 
            580                 585                 590         


Ser Gly Lys Ser Asn Leu Thr Val Leu Arg Glu Pro Glu Cys Gly Asn 
        595                 600                 605             


Thr Pro Asn Ala Met Thr Ile Leu Leu Ala Val Val Gly Ser Ile Leu 
    610                 615                 620                 


Leu Val Gly Leu Ala Leu Leu Ala Ile Trp Lys Leu Leu Val Thr Ile 
625                 630                 635                 640 


His Asp Arg Arg Glu Phe Ala Lys Phe Gln Ser Glu Arg Ser Arg Ala 
                645                 650                 655     


Arg Tyr Glu Met Ala Ser Asn Pro Leu Tyr Arg Lys Pro Ile Ser Thr 
            660                 665                 670         


His Thr Val Asp Phe Thr Phe Asn Lys Phe Asn Lys Ser Tyr Asn Gly 
        675                 680                 685             


Thr Val Asp 
    690     


<210>  189
<211>  788
<212>  PRT
<213>  Homo sapiens

<400>  189

Met Gly Ile Glu Leu Leu Cys Leu Phe Phe Leu Phe Leu Gly Arg Asn 
1               5                   10                  15      


Asp His Val Gln Gly Gly Cys Ala Leu Gly Gly Ala Glu Thr Cys Glu 
            20                  25                  30          


Asp Cys Leu Leu Ile Gly Pro Gln Cys Ala Trp Cys Ala Gln Glu Asn 
        35                  40                  45              


Phe Thr His Pro Ser Gly Val Gly Glu Arg Cys Asp Thr Pro Ala Asn 
    50                  55                  60                  


Leu Leu Ala Lys Gly Cys Gln Leu Asn Phe Ile Glu Asn Pro Val Ser 
65                  70                  75                  80  


Gln Val Glu Ile Leu Lys Asn Lys Pro Leu Ser Val Gly Arg Gln Lys 
                85                  90                  95      


Asn Ser Ser Asp Ile Val Gln Ile Ala Pro Gln Ser Leu Ile Leu Lys 
            100                 105                 110         


Leu Arg Pro Gly Gly Ala Gln Thr Leu Gln Val His Val Arg Gln Thr 
        115                 120                 125             


Glu Asp Tyr Pro Val Asp Leu Tyr Tyr Leu Met Asp Leu Ser Ala Ser 
    130                 135                 140                 


Met Asp Asp Asp Leu Asn Thr Ile Lys Glu Leu Gly Ser Arg Leu Ser 
145                 150                 155                 160 


Lys Glu Met Ser Lys Leu Thr Ser Asn Phe Arg Leu Gly Phe Gly Ser 
                165                 170                 175     


Phe Val Glu Lys Pro Val Ser Pro Phe Val Lys Thr Thr Pro Glu Glu 
            180                 185                 190         


Ile Ala Asn Pro Cys Ser Ser Ile Pro Tyr Phe Cys Leu Pro Thr Phe 
        195                 200                 205             


Gly Phe Lys His Ile Leu Pro Leu Thr Asn Asp Ala Glu Arg Phe Asn 
    210                 215                 220                 


Glu Ile Val Lys Asn Gln Lys Ile Ser Ala Asn Ile Asp Thr Pro Glu 
225                 230                 235                 240 


Gly Gly Phe Asp Ala Ile Met Gln Ala Ala Val Cys Lys Glu Lys Ile 
                245                 250                 255     


Gly Trp Arg Asn Asp Ser Leu His Leu Leu Val Phe Val Ser Asp Ala 
            260                 265                 270         


Asp Ser His Phe Gly Met Asp Ser Lys Leu Ala Gly Ile Val Ile Pro 
        275                 280                 285             


Asn Asp Gly Leu Cys His Leu Asp Ser Lys Asn Glu Tyr Ser Met Ser 
    290                 295                 300                 


Thr Val Leu Glu Tyr Pro Thr Ile Gly Gln Leu Ile Asp Lys Leu Val 
305                 310                 315                 320 


Gln Asn Asn Val Leu Leu Ile Phe Ala Val Thr Gln Glu Gln Val His 
                325                 330                 335     


Leu Tyr Glu Asn Tyr Ala Lys Leu Ile Pro Gly Ala Thr Val Gly Leu 
            340                 345                 350         


Leu Gln Lys Asp Ser Gly Asn Ile Leu Gln Leu Ile Ile Ser Ala Tyr 
        355                 360                 365             


Glu Glu Leu Arg Ser Glu Val Glu Leu Glu Val Leu Gly Asp Thr Glu 
    370                 375                 380                 


Gly Leu Asn Leu Ser Phe Thr Ala Ile Cys Asn Asn Gly Thr Leu Phe 
385                 390                 395                 400 


Gln His Gln Lys Lys Cys Ser His Met Lys Val Gly Asp Thr Ala Ser 
                405                 410                 415     


Phe Ser Val Thr Val Asn Ile Pro His Cys Glu Arg Arg Ser Arg His 
            420                 425                 430         


Ile Ile Ile Lys Pro Val Gly Leu Gly Asp Ala Leu Glu Leu Leu Val 
        435                 440                 445             


Ser Pro Glu Cys Asn Cys Asp Cys Gln Lys Glu Val Glu Val Asn Ser 
    450                 455                 460                 


Ser Lys Cys His His Gly Asn Gly Ser Phe Gln Cys Gly Val Cys Ala 
465                 470                 475                 480 


Cys His Pro Gly His Met Gly Pro Arg Cys Glu Cys Gly Glu Asp Met 
                485                 490                 495     


Leu Ser Thr Asp Ser Cys Lys Glu Ala Pro Asp His Pro Ser Cys Ser 
            500                 505                 510         


Gly Arg Gly Asp Cys Tyr Cys Gly Gln Cys Ile Cys His Leu Ser Pro 
        515                 520                 525             


Tyr Gly Asn Ile Tyr Gly Pro Tyr Cys Gln Cys Asp Asn Phe Ser Cys 
    530                 535                 540                 


Val Arg His Lys Gly Leu Leu Cys Gly Gly Asn Gly Asp Cys Asp Cys 
545                 550                 555                 560 


Gly Glu Cys Val Cys Arg Ser Gly Trp Thr Gly Glu Tyr Cys Asn Cys 
                565                 570                 575     


Thr Thr Ser Thr Asp Ser Cys Val Ser Glu Asp Gly Val Leu Cys Ser 
            580                 585                 590         


Gly Arg Gly Asp Cys Val Cys Gly Lys Cys Val Cys Thr Asn Pro Gly 
        595                 600                 605             


Ala Ser Gly Pro Thr Cys Glu Arg Cys Pro Thr Cys Gly Asp Pro Cys 
    610                 615                 620                 


Asn Ser Lys Arg Ser Cys Ile Glu Cys His Leu Ser Ala Ala Gly Gln 
625                 630                 635                 640 


Ala Arg Glu Glu Cys Val Asp Lys Cys Lys Leu Ala Gly Ala Thr Ile 
                645                 650                 655     


Ser Glu Glu Glu Asp Phe Ser Lys Asp Gly Ser Val Ser Cys Ser Leu 
            660                 665                 670         


Gln Gly Glu Asn Glu Cys Leu Ile Thr Phe Leu Ile Thr Thr Asp Asn 
        675                 680                 685             


Glu Gly Lys Thr Ile Ile His Ser Ile Asn Glu Lys Asp Cys Pro Lys 
    690                 695                 700                 


Pro Pro Asn Ile Pro Met Ile Met Leu Gly Val Ser Leu Ala Ile Leu 
705                 710                 715                 720 


Leu Ile Gly Val Val Leu Leu Cys Ile Trp Lys Leu Leu Val Ser Phe 
                725                 730                 735     


His Asp Arg Lys Glu Val Ala Lys Phe Glu Ala Glu Arg Ser Lys Ala 
            740                 745                 750         


Lys Trp Gln Thr Gly Thr Asn Pro Leu Tyr Arg Gly Ser Thr Ser Thr 
        755                 760                 765             


Phe Lys Asn Val Thr Tyr Lys His Arg Glu Lys Gln Lys Val Asp Leu 
    770                 775                 780                 


Ser Thr Asp Cys 
785             


<210>  190
<211>  798
<212>  PRT
<213>  Homo sapiens

<400>  190

Met Val Ala Leu Pro Met Val Leu Val Leu Leu Leu Val Leu Ser Arg 
1               5                   10                  15      


Gly Glu Ser Glu Leu Asp Ala Lys Ile Pro Ser Thr Gly Asp Ala Thr 
            20                  25                  30          


Glu Trp Arg Asn Pro His Leu Ser Met Leu Gly Ser Cys Gln Pro Ala 
        35                  40                  45              


Pro Ser Cys Gln Lys Cys Ile Leu Ser His Pro Ser Cys Ala Trp Cys 
    50                  55                  60                  


Lys Gln Leu Asn Phe Thr Ala Ser Gly Glu Ala Glu Ala Arg Arg Cys 
65                  70                  75                  80  


Ala Arg Arg Glu Glu Leu Leu Ala Arg Gly Cys Pro Leu Glu Glu Leu 
                85                  90                  95      


Glu Glu Pro Arg Gly Gln Gln Glu Val Leu Gln Asp Gln Pro Leu Ser 
            100                 105                 110         


Gln Gly Ala Arg Gly Glu Gly Ala Thr Gln Leu Ala Pro Gln Arg Val 
        115                 120                 125             


Arg Val Thr Leu Arg Pro Gly Glu Pro Gln Gln Leu Gln Val Arg Phe 
    130                 135                 140                 


Leu Arg Ala Glu Gly Tyr Pro Val Asp Leu Tyr Tyr Leu Met Asp Leu 
145                 150                 155                 160 


Ser Tyr Ser Met Lys Asp Asp Leu Glu Arg Val Arg Gln Leu Gly His 
                165                 170                 175     


Ala Leu Leu Val Arg Leu Gln Glu Val Thr His Ser Val Arg Ile Gly 
            180                 185                 190         


Phe Gly Ser Phe Val Asp Lys Thr Val Leu Pro Phe Val Ser Thr Val 
        195                 200                 205             


Pro Ser Lys Leu Arg His Pro Cys Pro Thr Arg Leu Glu Arg Cys Gln 
    210                 215                 220                 


Ser Pro Phe Ser Phe His His Val Leu Ser Leu Thr Gly Asp Ala Gln 
225                 230                 235                 240 


Ala Phe Glu Arg Glu Val Gly Arg Gln Ser Val Ser Gly Asn Leu Asp 
                245                 250                 255     


Ser Pro Glu Gly Gly Phe Asp Ala Ile Leu Gln Ala Ala Leu Cys Gln 
            260                 265                 270         


Glu Gln Ile Gly Trp Arg Asn Val Ser Arg Leu Leu Val Phe Thr Ser 
        275                 280                 285             


Asp Asp Thr Phe His Thr Ala Gly Asp Gly Lys Leu Gly Gly Ile Phe 
    290                 295                 300                 


Met Pro Ser Asp Gly His Cys His Leu Asp Ser Asn Gly Leu Tyr Ser 
305                 310                 315                 320 


Arg Ser Thr Glu Phe Asp Tyr Pro Ser Val Gly Gln Val Ala Gln Ala 
                325                 330                 335     


Leu Ser Ala Ala Asn Ile Gln Pro Ile Phe Ala Val Thr Ser Ala Ala 
            340                 345                 350         


Leu Pro Val Tyr Gln Glu Leu Ser Lys Leu Ile Pro Lys Ser Ala Val 
        355                 360                 365             


Gly Glu Leu Ser Glu Asp Ser Ser Asn Val Val Gln Leu Ile Met Asp 
    370                 375                 380                 


Ala Tyr Asn Ser Leu Ser Ser Thr Val Thr Leu Glu His Ser Ser Leu 
385                 390                 395                 400 


Pro Pro Gly Val His Ile Ser Tyr Glu Ser Gln Cys Glu Gly Pro Glu 
                405                 410                 415     


Lys Arg Glu Gly Lys Ala Glu Asp Arg Gly Gln Cys Asn His Val Arg 
            420                 425                 430         


Ile Asn Gln Thr Val Thr Phe Trp Val Ser Leu Gln Ala Thr His Cys 
        435                 440                 445             


Leu Pro Glu Pro His Leu Leu Arg Leu Arg Ala Leu Gly Phe Ser Glu 
    450                 455                 460                 


Glu Leu Ile Val Glu Leu His Thr Leu Cys Asp Cys Asn Cys Ser Asp 
465                 470                 475                 480 


Thr Gln Pro Gln Ala Pro His Cys Ser Asp Gly Gln Gly His Leu Gln 
                485                 490                 495     


Cys Gly Val Cys Ser Cys Ala Pro Gly Arg Leu Gly Arg Leu Cys Glu 
            500                 505                 510         


Cys Ser Val Ala Glu Leu Ser Ser Pro Asp Leu Glu Ser Gly Cys Arg 
        515                 520                 525             


Ala Pro Asn Gly Thr Gly Pro Leu Cys Ser Gly Lys Gly His Cys Gln 
    530                 535                 540                 


Cys Gly Arg Cys Ser Cys Ser Gly Gln Ser Ser Gly His Leu Cys Glu 
545                 550                 555                 560 


Cys Asp Asp Ala Ser Cys Glu Arg His Glu Gly Ile Leu Cys Gly Gly 
                565                 570                 575     


Phe Gly Arg Cys Gln Cys Gly Val Cys His Cys His Ala Asn Arg Thr 
            580                 585                 590         


Gly Arg Ala Cys Glu Cys Ser Gly Asp Met Asp Ser Cys Ile Ser Pro 
        595                 600                 605             


Glu Gly Gly Leu Cys Ser Gly His Gly Arg Cys Lys Cys Asn Arg Cys 
    610                 615                 620                 


Gln Cys Leu Asp Gly Tyr Tyr Gly Ala Leu Cys Asp Gln Cys Pro Gly 
625                 630                 635                 640 


Cys Lys Thr Pro Cys Glu Arg His Arg Asp Cys Ala Glu Cys Gly Ala 
                645                 650                 655     


Phe Arg Thr Gly Pro Leu Ala Thr Asn Cys Ser Thr Ala Cys Ala His 
            660                 665                 670         


Thr Asn Val Thr Leu Ala Leu Ala Pro Ile Leu Asp Asp Gly Trp Cys 
        675                 680                 685             


Lys Glu Arg Thr Leu Asp Asn Gln Leu Phe Phe Phe Leu Val Glu Asp 
    690                 695                 700                 


Asp Ala Arg Gly Thr Val Val Leu Arg Val Arg Pro Gln Glu Lys Gly 
705                 710                 715                 720 


Ala Asp His Thr Gln Ala Ile Val Leu Gly Cys Val Gly Gly Ile Val 
                725                 730                 735     


Ala Val Gly Leu Gly Leu Val Leu Ala Tyr Arg Leu Ser Val Glu Ile 
            740                 745                 750         


Tyr Asp Arg Arg Glu Tyr Ser Arg Phe Glu Lys Glu Gln Gln Gln Leu 
        755                 760                 765             


Asn Trp Lys Gln Asp Ser Asn Pro Leu Tyr Lys Ser Ala Ile Thr Thr 
    770                 775                 780                 


Thr Ile Asn Pro Arg Phe Gln Glu Ala Asp Ser Pro Thr Leu 
785                 790                 795             


<210>  191
<211>  760
<212>  PRT
<213>  Homo sapiens

<400>  191

Met Met Asp Gln Ala Arg Ser Ala Phe Ser Asn Leu Phe Gly Gly Glu 
1               5                   10                  15      


Pro Leu Ser Tyr Thr Arg Phe Ser Leu Ala Arg Gln Val Asp Gly Asp 
            20                  25                  30          


Asn Ser His Val Glu Met Lys Leu Ala Val Asp Glu Glu Glu Asn Ala 
        35                  40                  45              


Asp Asn Asn Thr Lys Ala Asn Val Thr Lys Pro Lys Arg Cys Ser Gly 
    50                  55                  60                  


Ser Ile Cys Tyr Gly Thr Ile Ala Val Ile Val Phe Phe Leu Ile Gly 
65                  70                  75                  80  


Phe Met Ile Gly Tyr Leu Gly Tyr Cys Lys Gly Val Glu Pro Lys Thr 
                85                  90                  95      


Glu Cys Glu Arg Leu Ala Gly Thr Glu Ser Pro Val Arg Glu Glu Pro 
            100                 105                 110         


Gly Glu Asp Phe Pro Ala Ala Arg Arg Leu Tyr Trp Asp Asp Leu Lys 
        115                 120                 125             


Arg Lys Leu Ser Glu Lys Leu Asp Ser Thr Asp Phe Thr Gly Thr Ile 
    130                 135                 140                 


Lys Leu Leu Asn Glu Asn Ser Tyr Val Pro Arg Glu Ala Gly Ser Gln 
145                 150                 155                 160 


Lys Asp Glu Asn Leu Ala Leu Tyr Val Glu Asn Gln Phe Arg Glu Phe 
                165                 170                 175     


Lys Leu Ser Lys Val Trp Arg Asp Gln His Phe Val Lys Ile Gln Val 
            180                 185                 190         


Lys Asp Ser Ala Gln Asn Ser Val Ile Ile Val Asp Lys Asn Gly Arg 
        195                 200                 205             


Leu Val Tyr Leu Val Glu Asn Pro Gly Gly Tyr Val Ala Tyr Ser Lys 
    210                 215                 220                 


Ala Ala Thr Val Thr Gly Lys Leu Val His Ala Asn Phe Gly Thr Lys 
225                 230                 235                 240 


Lys Asp Phe Glu Asp Leu Tyr Thr Pro Val Asn Gly Ser Ile Val Ile 
                245                 250                 255     


Val Arg Ala Gly Lys Ile Thr Phe Ala Glu Lys Val Ala Asn Ala Glu 
            260                 265                 270         


Ser Leu Asn Ala Ile Gly Val Leu Ile Tyr Met Asp Gln Thr Lys Phe 
        275                 280                 285             


Pro Ile Val Asn Ala Glu Leu Ser Phe Phe Gly His Ala His Leu Gly 
    290                 295                 300                 


Thr Gly Asp Pro Tyr Thr Pro Gly Phe Pro Ser Phe Asn His Thr Gln 
305                 310                 315                 320 


Phe Pro Pro Ser Arg Ser Ser Gly Leu Pro Asn Ile Pro Val Gln Thr 
                325                 330                 335     


Ile Ser Arg Ala Ala Ala Glu Lys Leu Phe Gly Asn Met Glu Gly Asp 
            340                 345                 350         


Cys Pro Ser Asp Trp Lys Thr Asp Ser Thr Cys Arg Met Val Thr Ser 
        355                 360                 365             


Glu Ser Lys Asn Val Lys Leu Thr Val Ser Asn Val Leu Lys Glu Ile 
    370                 375                 380                 


Lys Ile Leu Asn Ile Phe Gly Val Ile Lys Gly Phe Val Glu Pro Asp 
385                 390                 395                 400 


His Tyr Val Val Val Gly Ala Gln Arg Asp Ala Trp Gly Pro Gly Ala 
                405                 410                 415     


Ala Lys Ser Gly Val Gly Thr Ala Leu Leu Leu Lys Leu Ala Gln Met 
            420                 425                 430         


Phe Ser Asp Met Val Leu Lys Asp Gly Phe Gln Pro Ser Arg Ser Ile 
        435                 440                 445             


Ile Phe Ala Ser Trp Ser Ala Gly Asp Phe Gly Ser Val Gly Ala Thr 
    450                 455                 460                 


Glu Trp Leu Glu Gly Tyr Leu Ser Ser Leu His Leu Lys Ala Phe Thr 
465                 470                 475                 480 


Tyr Ile Asn Leu Asp Lys Ala Val Leu Gly Thr Ser Asn Phe Lys Val 
                485                 490                 495     


Ser Ala Ser Pro Leu Leu Tyr Thr Leu Ile Glu Lys Thr Met Gln Asn 
            500                 505                 510         


Val Lys His Pro Val Thr Gly Gln Phe Leu Tyr Gln Asp Ser Asn Trp 
        515                 520                 525             


Ala Ser Lys Val Glu Lys Leu Thr Leu Asp Asn Ala Ala Phe Pro Phe 
    530                 535                 540                 


Leu Ala Tyr Ser Gly Ile Pro Ala Val Ser Phe Cys Phe Cys Glu Asp 
545                 550                 555                 560 


Thr Asp Tyr Pro Tyr Leu Gly Thr Thr Met Asp Thr Tyr Lys Glu Leu 
                565                 570                 575     


Ile Glu Arg Ile Pro Glu Leu Asn Lys Val Ala Arg Ala Ala Ala Glu 
            580                 585                 590         


Val Ala Gly Gln Phe Val Ile Lys Leu Thr His Asp Val Glu Leu Asn 
        595                 600                 605             


Leu Asp Tyr Glu Arg Tyr Asn Ser Gln Leu Leu Ser Phe Val Arg Asp 
    610                 615                 620                 


Leu Asn Gln Tyr Arg Ala Asp Ile Lys Glu Met Gly Leu Ser Leu Gln 
625                 630                 635                 640 


Trp Leu Tyr Ser Ala Arg Gly Asp Phe Phe Arg Ala Thr Ser Arg Leu 
                645                 650                 655     


Thr Thr Asp Phe Gly Asn Ala Glu Lys Thr Asp Arg Phe Val Met Lys 
            660                 665                 670         


Lys Leu Asn Asp Arg Val Met Arg Val Glu Tyr His Phe Leu Ser Pro 
        675                 680                 685             


Tyr Val Ser Pro Lys Glu Ser Pro Phe Arg His Val Phe Trp Gly Ser 
    690                 695                 700                 


Gly Ser His Thr Leu Pro Ala Leu Leu Glu Asn Leu Lys Leu Arg Lys 
705                 710                 715                 720 


Gln Asn Asn Gly Ala Phe Asn Glu Thr Leu Phe Arg Asn Gln Leu Ala 
                725                 730                 735     


Leu Ala Thr Trp Thr Ile Gln Gly Ala Ala Asn Ala Leu Ser Gly Asp 
            740                 745                 750         


Val Trp Asp Ile Asp Asn Glu Phe 
        755                 760 


<210>  192
<211>  310
<212>  PRT
<213>  Homo sapiens

<400>  192

Met Arg Arg Ala Ala Leu Trp Leu Trp Leu Cys Ala Leu Ala Leu Ser 
1               5                   10                  15      


Leu Gln Pro Ala Leu Pro Gln Ile Val Ala Thr Asn Leu Pro Pro Glu 
            20                  25                  30          


Asp Gln Asp Gly Ser Gly Asp Asp Ser Asp Asn Phe Ser Gly Ser Gly 
        35                  40                  45              


Ala Gly Ala Leu Gln Asp Ile Thr Leu Ser Gln Gln Thr Pro Ser Thr 
    50                  55                  60                  


Trp Lys Asp Thr Gln Leu Leu Thr Ala Ile Pro Thr Ser Pro Glu Pro 
65                  70                  75                  80  


Thr Gly Leu Glu Ala Thr Ala Ala Ser Thr Ser Thr Leu Pro Ala Gly 
                85                  90                  95      


Glu Gly Pro Lys Glu Gly Glu Ala Val Val Leu Pro Glu Val Glu Pro 
            100                 105                 110         


Gly Leu Thr Ala Arg Glu Gln Glu Ala Thr Pro Arg Pro Arg Glu Thr 
        115                 120                 125             


Thr Gln Leu Pro Thr Thr His Gln Ala Ser Thr Thr Thr Ala Thr Thr 
    130                 135                 140                 


Ala Gln Glu Pro Ala Thr Ser His Pro His Arg Asp Met Gln Pro Gly 
145                 150                 155                 160 


His His Glu Thr Ser Thr Pro Ala Gly Pro Ser Gln Ala Asp Leu His 
                165                 170                 175     


Thr Pro His Thr Glu Asp Gly Gly Pro Ser Ala Thr Glu Arg Ala Ala 
            180                 185                 190         


Glu Asp Gly Ala Ser Ser Gln Leu Pro Ala Ala Glu Gly Ser Gly Glu 
        195                 200                 205             


Gln Asp Phe Thr Phe Glu Thr Ser Gly Glu Asn Thr Ala Val Val Ala 
    210                 215                 220                 


Val Glu Pro Asp Arg Arg Asn Gln Ser Pro Val Asp Gln Gly Ala Thr 
225                 230                 235                 240 


Gly Ala Ser Gln Gly Leu Leu Asp Arg Lys Glu Val Leu Gly Gly Val 
                245                 250                 255     


Ile Ala Gly Gly Leu Val Gly Leu Ile Phe Ala Val Cys Leu Val Gly 
            260                 265                 270         


Phe Met Leu Tyr Arg Met Lys Lys Lys Asp Glu Gly Ser Tyr Ser Leu 
        275                 280                 285             


Glu Glu Pro Lys Gln Ala Asn Gly Gly Ala Tyr Gln Lys Pro Thr Lys 
    290                 295                 300                 


Gln Glu Glu Phe Tyr Ala 
305                 310 


<210>  193
<211>  201
<212>  PRT
<213>  Homo sapiens

<400>  193

Met Arg Arg Ala Trp Ile Leu Leu Thr Leu Gly Leu Val Ala Cys Val 
1               5                   10                  15      


Ser Ala Glu Ser Arg Ala Glu Leu Thr Ser Asp Lys Asp Met Tyr Leu 
            20                  25                  30          


Asp Asn Ser Ser Ile Glu Glu Ala Ser Gly Val Tyr Pro Ile Asp Asp 
        35                  40                  45              


Asp Asp Tyr Ala Ser Ala Ser Gly Ser Gly Ala Asp Glu Asp Val Glu 
    50                  55                  60                  


Ser Pro Glu Leu Thr Thr Ser Arg Pro Leu Pro Lys Ile Leu Leu Thr 
65                  70                  75                  80  


Ser Ala Ala Pro Lys Val Glu Thr Thr Thr Leu Asn Ile Gln Asn Lys 
                85                  90                  95      


Ile Pro Ala Gln Thr Lys Ser Pro Glu Glu Thr Asp Lys Glu Lys Val 
            100                 105                 110         


His Leu Ser Asp Ser Glu Arg Lys Met Asp Pro Ala Glu Glu Asp Thr 
        115                 120                 125             


Asn Val Tyr Thr Glu Lys His Ser Asp Ser Leu Phe Lys Arg Thr Glu 
    130                 135                 140                 


Val Leu Ala Ala Val Ile Ala Gly Gly Val Ile Gly Phe Leu Phe Ala 
145                 150                 155                 160 


Ile Phe Leu Ile Leu Leu Leu Val Tyr Arg Met Arg Lys Lys Asp Glu 
                165                 170                 175     


Gly Ser Tyr Asp Leu Gly Glu Arg Lys Pro Ser Ser Ala Ala Tyr Gln 
            180                 185                 190         


Lys Ala Pro Thr Lys Glu Phe Tyr Ala 
        195                 200     


<210>  194
<211>  442
<212>  PRT
<213>  Homo sapiens

<400>  194

Met Lys Pro Gly Pro Pro His Arg Ala Gly Ala Ala His Gly Ala Gly 
1               5                   10                  15      


Ala Gly Ala Gly Ala Ala Ala Gly Pro Gly Ala Arg Gly Leu Leu Leu 
            20                  25                  30          


Pro Pro Leu Leu Leu Leu Leu Leu Ala Gly Arg Ala Ala Gly Ala Gln 
        35                  40                  45              


Arg Trp Arg Ser Glu Asn Phe Glu Arg Pro Val Asp Leu Glu Gly Ser 
    50                  55                  60                  


Gly Asp Asp Asp Ser Phe Pro Asp Asp Glu Leu Asp Asp Leu Tyr Ser 
65                  70                  75                  80  


Gly Ser Gly Ser Gly Tyr Phe Glu Gln Glu Ser Gly Ile Glu Thr Ala 
                85                  90                  95      


Met Arg Phe Ser Pro Asp Val Ala Leu Ala Val Ser Thr Thr Pro Ala 
            100                 105                 110         


Val Leu Pro Thr Thr Asn Ile Gln Pro Val Gly Thr Pro Phe Glu Glu 
        115                 120                 125             


Leu Pro Ser Glu Arg Pro Thr Leu Glu Pro Ala Thr Ser Pro Leu Val 
    130                 135                 140                 


Val Thr Glu Val Pro Glu Glu Pro Ser Gln Arg Ala Thr Thr Val Ser 
145                 150                 155                 160 


Thr Thr Met Ala Thr Thr Ala Ala Thr Ser Thr Gly Asp Pro Thr Val 
                165                 170                 175     


Ala Thr Val Pro Ala Thr Val Ala Thr Ala Thr Pro Ser Thr Pro Ala 
            180                 185                 190         


Ala Pro Pro Phe Thr Ala Thr Thr Ala Val Ile Arg Thr Thr Gly Val 
        195                 200                 205             


Arg Arg Leu Leu Pro Leu Pro Leu Thr Thr Val Ala Thr Ala Arg Ala 
    210                 215                 220                 


Thr Thr Pro Glu Ala Pro Ser Pro Pro Thr Thr Ala Ala Val Leu Asp 
225                 230                 235                 240 


Thr Glu Ala Pro Thr Pro Arg Leu Val Ser Thr Ala Thr Ser Arg Pro 
                245                 250                 255     


Arg Ala Leu Pro Arg Pro Ala Thr Thr Gln Glu Pro Asp Ile Pro Glu 
            260                 265                 270         


Arg Ser Thr Leu Pro Leu Gly Thr Thr Ala Pro Gly Pro Thr Glu Val 
        275                 280                 285             


Ala Gln Thr Pro Thr Pro Glu Thr Phe Leu Thr Thr Ile Arg Asp Glu 
    290                 295                 300                 


Pro Glu Val Pro Val Ser Gly Gly Pro Ser Gly Asp Phe Glu Leu Pro 
305                 310                 315                 320 


Glu Glu Glu Thr Thr Gln Pro Asp Thr Ala Asn Glu Val Val Ala Val 
                325                 330                 335     


Gly Gly Ala Ala Ala Lys Ala Ser Ser Pro Pro Gly Thr Leu Pro Lys 
            340                 345                 350         


Gly Ala Arg Pro Gly Pro Gly Leu Leu Asp Asn Ala Ile Asp Ser Gly 
        355                 360                 365             


Ser Ser Ala Ala Gln Leu Pro Gln Lys Ser Ile Leu Glu Arg Lys Glu 
    370                 375                 380                 


Val Leu Val Ala Val Ile Val Gly Gly Val Val Gly Ala Leu Phe Ala 
385                 390                 395                 400 


Ala Phe Leu Val Thr Leu Leu Ile Tyr Arg Met Lys Lys Lys Asp Glu 
                405                 410                 415     


Gly Ser Tyr Thr Leu Glu Glu Pro Lys Gln Ala Ser Val Thr Tyr Gln 
            420                 425                 430         


Lys Pro Asp Lys Gln Glu Glu Phe Tyr Ala 
        435                 440         


<210>  195
<211>  198
<212>  PRT
<213>  Homo sapiens

<400>  195

Met Ala Pro Ala Arg Leu Phe Ala Leu Leu Leu Phe Phe Val Gly Gly 
1               5                   10                  15      


Val Ala Glu Ser Ile Arg Glu Thr Glu Val Ile Asp Pro Gln Asp Leu 
            20                  25                  30          


Leu Glu Gly Arg Tyr Phe Ser Gly Ala Leu Pro Asp Asp Glu Asp Val 
        35                  40                  45              


Val Gly Pro Gly Gln Glu Ser Asp Asp Phe Glu Leu Ser Gly Ser Gly 
    50                  55                  60                  


Asp Leu Asp Asp Leu Glu Asp Ser Met Ile Gly Pro Glu Val Val His 
65                  70                  75                  80  


Pro Leu Val Pro Leu Asp Asn His Ile Pro Glu Arg Ala Gly Ser Gly 
                85                  90                  95      


Ser Gln Val Pro Thr Glu Pro Lys Lys Leu Glu Glu Asn Glu Val Ile 
            100                 105                 110         


Pro Lys Arg Ile Ser Pro Val Glu Glu Ser Glu Asp Val Ser Asn Lys 
        115                 120                 125             


Val Ser Met Ser Ser Thr Val Gln Gly Ser Asn Ile Phe Glu Arg Thr 
    130                 135                 140                 


Glu Val Leu Ala Ala Leu Ile Val Gly Gly Ile Val Gly Ile Leu Phe 
145                 150                 155                 160 


Ala Val Phe Leu Ile Leu Leu Leu Met Tyr Arg Met Lys Lys Lys Asp 
                165                 170                 175     


Glu Gly Ser Tyr Asp Leu Gly Lys Lys Pro Ile Tyr Lys Lys Ala Pro 
            180                 185                 190         


Thr Asn Glu Phe Tyr Ala 
        195             


<210>  196
<211>  4392
<212>  PRT
<213>  Homo sapiens

<400>  196

Met Gly Trp Arg Ala Ala Gly Ala Leu Leu Leu Ala Leu Leu Leu His 
1               5                   10                  15      


Gly Arg Leu Leu Ala Val Thr His Gly Leu Arg Ala Tyr Asp Gly Leu 
            20                  25                  30          


Ser Leu Pro Glu Asp Ile Glu Thr Val Thr Ala Ser Gln Met Arg Trp 
        35                  40                  45              


Thr His Ser Tyr Leu Ser Asp Asp Glu Asp Met Leu Ala Asp Ser Ile 
    50                  55                  60                  


Ser Gly Asp Asp Leu Gly Ser Gly Asp Leu Gly Ser Gly Asp Phe Gln 
65                  70                  75                  80  


Met Val Tyr Phe Arg Ala Leu Val Asn Phe Thr Arg Ser Ile Glu Tyr 
                85                  90                  95      


Ser Pro Gln Leu Glu Asp Ala Gly Ser Arg Glu Phe Arg Glu Val Ser 
            100                 105                 110         


Glu Ala Val Val Asp Thr Leu Glu Ser Glu Tyr Leu Lys Ile Pro Gly 
        115                 120                 125             


Asp Gln Val Val Ser Val Val Phe Ile Lys Glu Leu Asp Gly Trp Val 
    130                 135                 140                 


Phe Val Glu Leu Asp Val Gly Ser Glu Gly Asn Ala Asp Gly Ala Gln 
145                 150                 155                 160 


Ile Gln Glu Met Leu Leu Arg Val Ile Ser Ser Gly Ser Val Ala Ser 
                165                 170                 175     


Tyr Val Thr Ser Pro Gln Gly Phe Gln Phe Arg Arg Leu Gly Thr Val 
            180                 185                 190         


Pro Gln Phe Pro Arg Ala Cys Thr Glu Ala Glu Phe Ala Cys His Ser 
        195                 200                 205             


Tyr Asn Glu Cys Val Ala Leu Glu Tyr Arg Cys Asp Arg Arg Pro Asp 
    210                 215                 220                 


Cys Arg Asp Met Ser Asp Glu Leu Asn Cys Glu Glu Pro Val Leu Gly 
225                 230                 235                 240 


Ile Ser Pro Thr Phe Ser Leu Leu Val Glu Thr Thr Ser Leu Pro Pro 
                245                 250                 255     


Arg Pro Glu Thr Thr Ile Met Arg Gln Pro Pro Val Thr His Ala Pro 
            260                 265                 270         


Gln Pro Leu Leu Pro Gly Ser Val Arg Pro Leu Pro Cys Gly Pro Gln 
        275                 280                 285             


Glu Ala Ala Cys Arg Asn Gly His Cys Ile Pro Arg Asp Tyr Leu Cys 
    290                 295                 300                 


Asp Gly Gln Glu Asp Cys Glu Asp Gly Ser Asp Glu Leu Asp Cys Gly 
305                 310                 315                 320 


Pro Pro Pro Pro Cys Glu Pro Asn Glu Phe Pro Cys Gly Asn Gly His 
                325                 330                 335     


Cys Ala Leu Lys Leu Trp Arg Cys Asp Gly Asp Phe Asp Cys Glu Asp 
            340                 345                 350         


Arg Thr Asp Glu Ala Asn Cys Pro Thr Lys Arg Pro Glu Glu Val Cys 
        355                 360                 365             


Gly Pro Thr Gln Phe Arg Cys Val Ser Thr Asn Met Cys Ile Pro Ala 
    370                 375                 380                 


Ser Phe His Cys Asp Glu Glu Ser Asp Cys Pro Asp Arg Ser Asp Glu 
385                 390                 395                 400 


Phe Gly Cys Met Pro Pro Gln Val Val Thr Pro Pro Arg Glu Ser Ile 
                405                 410                 415     


Gln Ala Ser Arg Gly Gln Thr Val Thr Phe Thr Cys Val Ala Ile Gly 
            420                 425                 430         


Val Pro Thr Pro Ile Ile Asn Trp Arg Leu Asn Trp Gly His Ile Pro 
        435                 440                 445             


Ser His Pro Arg Val Thr Val Thr Ser Glu Gly Gly Arg Gly Thr Leu 
    450                 455                 460                 


Ile Ile Arg Asp Val Lys Glu Ser Asp Gln Gly Ala Tyr Thr Cys Glu 
465                 470                 475                 480 


Ala Met Asn Ala Arg Gly Met Val Phe Gly Ile Pro Asp Gly Val Leu 
                485                 490                 495     


Glu Leu Val Pro Gln Arg Ala Gly Pro Cys Pro Asp Gly His Phe Tyr 
            500                 505                 510         


Leu Glu His Ser Ala Ala Cys Leu Pro Cys Phe Cys Phe Gly Ile Thr 
        515                 520                 525             


Ser Val Cys Gln Ser Thr Arg Arg Phe Arg Asp Gln Ile Arg Leu Arg 
    530                 535                 540                 


Phe Asp Gln Pro Asp Asp Phe Lys Gly Val Asn Val Thr Met Pro Ala 
545                 550                 555                 560 


Gln Pro Gly Thr Pro Pro Leu Ser Ser Thr Gln Leu Gln Ile Asp Pro 
                565                 570                 575     


Ser Leu His Glu Phe Gln Leu Val Asp Leu Ser Arg Arg Phe Leu Val 
            580                 585                 590         


His Asp Ser Phe Trp Ala Leu Pro Glu Gln Phe Leu Gly Asn Lys Val 
        595                 600                 605             


Asp Ser Tyr Gly Gly Ser Leu Arg Tyr Asn Val Arg Tyr Glu Leu Ala 
    610                 615                 620                 


Arg Gly Met Leu Glu Pro Val Gln Arg Pro Asp Val Val Leu Met Gly 
625                 630                 635                 640 


Ala Gly Tyr Arg Leu Leu Ser Arg Gly His Thr Pro Thr Gln Pro Gly 
                645                 650                 655     


Ala Leu Asn Gln Arg Gln Val Gln Phe Ser Glu Glu His Trp Val His 
            660                 665                 670         


Glu Ser Gly Arg Pro Val Gln Arg Ala Glu Leu Leu Gln Val Leu Gln 
        675                 680                 685             


Ser Leu Glu Ala Val Leu Ile Gln Thr Val Tyr Asn Thr Lys Met Ala 
    690                 695                 700                 


Ser Val Gly Leu Ser Asp Ile Ala Met Asp Thr Thr Val Thr His Ala 
705                 710                 715                 720 


Thr Ser His Gly Arg Ala His Ser Val Glu Glu Cys Arg Cys Pro Ile 
                725                 730                 735     


Gly Tyr Ser Gly Leu Ser Cys Glu Ser Cys Asp Ala His Phe Thr Arg 
            740                 745                 750         


Val Pro Gly Gly Pro Tyr Leu Gly Thr Cys Ser Gly Cys Asn Cys Asn 
        755                 760                 765             


Gly His Ala Ser Ser Cys Asp Pro Val Tyr Gly His Cys Leu Asn Cys 
    770                 775                 780                 


Gln His Asn Thr Glu Gly Pro Gln Cys Asn Lys Cys Lys Ala Gly Phe 
785                 790                 795                 800 


Phe Gly Asp Ala Met Lys Ala Thr Ala Thr Ser Cys Arg Pro Cys Pro 
                805                 810                 815     


Cys Pro Tyr Ile Asp Ala Ser Arg Arg Phe Ser Asp Thr Cys Phe Leu 
            820                 825                 830         


Asp Thr Asp Gly Gln Ala Thr Cys Asp Ala Cys Ala Pro Gly Tyr Thr 
        835                 840                 845             


Gly Arg Arg Cys Glu Ser Cys Ala Pro Gly Tyr Glu Gly Asn Pro Ile 
    850                 855                 860                 


Gln Pro Gly Gly Lys Cys Arg Pro Val Asn Gln Glu Ile Val Arg Cys 
865                 870                 875                 880 


Asp Glu Arg Gly Ser Met Gly Thr Ser Gly Glu Ala Cys Arg Cys Lys 
                885                 890                 895     


Asn Asn Val Val Gly Arg Leu Cys Asn Glu Cys Ala Asp Gly Ser Phe 
            900                 905                 910         


His Leu Ser Thr Arg Asn Pro Asp Gly Cys Leu Lys Cys Phe Cys Met 
        915                 920                 925             


Gly Val Ser Arg His Cys Thr Ser Ser Ser Trp Ser Arg Ala Gln Leu 
    930                 935                 940                 


His Gly Ala Ser Glu Glu Pro Gly His Phe Ser Leu Thr Asn Ala Ala 
945                 950                 955                 960 


Ser Thr His Thr Thr Asn Glu Gly Ile Phe Ser Pro Thr Pro Gly Glu 
                965                 970                 975     


Leu Gly Phe Ser Ser Phe His Arg Leu Leu Ser Gly Pro Tyr Phe Trp 
            980                 985                 990         


Ser Leu Pro Ser Arg Phe Leu Gly  Asp Lys Val Thr Ser  Tyr Gly Gly 
        995                 1000                 1005             


Glu Leu  Arg Phe Thr Val Thr  Gln Arg Ser Gln Pro  Gly Ser Thr 
    1010                 1015                 1020             


Pro Leu  His Gly Gln Pro Leu  Val Val Leu Gln Gly  Asn Asn Ile 
    1025                 1030                 1035             


Ile Leu  Glu His His Val Ala  Gln Glu Pro Ser Pro  Gly Gln Pro 
    1040                 1045                 1050             


Ser Thr  Phe Ile Val Pro Phe  Arg Glu Gln Ala Trp  Gln Arg Pro 
    1055                 1060                 1065             


Asp Gly  Gln Pro Ala Thr Arg  Glu His Leu Leu Met  Ala Leu Ala 
    1070                 1075                 1080             


Gly Ile  Asp Thr Leu Leu Ile  Arg Ala Ser Tyr Ala  Gln Gln Pro 
    1085                 1090                 1095             


Ala Glu  Ser Arg Val Ser Gly  Ile Ser Met Asp Val  Ala Val Pro 
    1100                 1105                 1110             


Glu Glu  Thr Gly Gln Asp Pro  Ala Leu Glu Val Glu  Gln Cys Ser 
    1115                 1120                 1125             


Cys Pro  Pro Gly Tyr Arg Gly  Pro Ser Cys Gln Asp  Cys Asp Thr 
    1130                 1135                 1140             


Gly Tyr  Thr Arg Thr Pro Ser  Gly Leu Tyr Leu Gly  Thr Cys Glu 
    1145                 1150                 1155             


Arg Cys  Ser Cys His Gly His  Ser Glu Ala Cys Glu  Pro Glu Thr 
    1160                 1165                 1170             


Gly Ala  Cys Gln Gly Cys Gln  His His Thr Glu Gly  Pro Arg Cys 
    1175                 1180                 1185             


Glu Gln  Cys Gln Pro Gly Tyr  Tyr Gly Asp Ala Gln  Arg Gly Thr 
    1190                 1195                 1200             


Pro Gln  Asp Cys Gln Leu Cys  Pro Cys Tyr Gly Asp  Pro Ala Ala 
    1205                 1210                 1215             


Gly Gln  Ala Ala His Thr Cys  Phe Leu Asp Thr Asp  Gly His Pro 
    1220                 1225                 1230             


Thr Cys  Asp Ala Cys Ser Pro  Gly His Ser Gly Arg  His Cys Glu 
    1235                 1240                 1245             


Arg Cys  Ala Pro Gly Tyr Tyr  Gly Asn Pro Ser Gln  Gly Gln Pro 
    1250                 1255                 1260             


Cys Gln  Arg Asp Ser Gln Val  Pro Gly Pro Ile Gly  Cys Asn Cys 
    1265                 1270                 1275             


Asp Pro  Gln Gly Ser Val Ser  Ser Gln Cys Asp Ala  Ala Gly Gln 
    1280                 1285                 1290             


Cys Gln  Cys Lys Ala Gln Val  Glu Gly Leu Thr Cys  Ser His Cys 
    1295                 1300                 1305             


Arg Pro  His His Phe His Leu  Ser Ala Ser Asn Pro  Asp Gly Cys 
    1310                 1315                 1320             


Leu Pro  Cys Phe Cys Met Gly  Ile Thr Gln Gln Cys  Ala Ser Ser 
    1325                 1330                 1335             


Ala Tyr  Thr Arg His Leu Ile  Ser Thr His Phe Ala  Pro Gly Asp 
    1340                 1345                 1350             


Phe Gln  Gly Phe Ala Leu Val  Asn Pro Gln Arg Asn  Ser Arg Leu 
    1355                 1360                 1365             


Thr Gly  Glu Phe Thr Val Glu  Pro Val Pro Glu Gly  Ala Gln Leu 
    1370                 1375                 1380             


Ser Phe  Gly Asn Phe Ala Gln  Leu Gly His Glu Ser  Phe Tyr Trp 
    1385                 1390                 1395             


Gln Leu  Pro Glu Thr Tyr Gln  Gly Asp Lys Val Ala  Ala Tyr Gly 
    1400                 1405                 1410             


Gly Lys  Leu Arg Tyr Thr Leu  Ser Tyr Thr Ala Gly  Pro Gln Gly 
    1415                 1420                 1425             


Ser Pro  Leu Ser Asp Pro Asp  Val Gln Ile Thr Gly  Asn Asn Ile 
    1430                 1435                 1440             


Met Leu  Val Ala Ser Gln Pro  Ala Leu Gln Gly Pro  Glu Arg Arg 
    1445                 1450                 1455             


Ser Tyr  Glu Ile Met Phe Arg  Glu Glu Phe Trp Arg  Arg Pro Asp 
    1460                 1465                 1470             


Gly Gln  Pro Ala Thr Arg Glu  His Leu Leu Met Ala  Leu Ala Asp 
    1475                 1480                 1485             


Leu Asp  Glu Leu Leu Ile Arg  Ala Thr Phe Ser Ser  Val Pro Leu 
    1490                 1495                 1500             


Ala Ala  Ser Ile Ser Ala Val  Ser Leu Glu Val Ala  Gln Pro Gly 
    1505                 1510                 1515             


Pro Ser  Asn Arg Pro Arg Ala  Leu Glu Val Glu Glu  Cys Arg Cys 
    1520                 1525                 1530             


Pro Pro  Gly Tyr Ile Gly Leu  Ser Cys Gln Asp Cys  Ala Pro Gly 
    1535                 1540                 1545             


Tyr Thr  Arg Thr Gly Ser Gly  Leu Tyr Leu Gly His  Cys Glu Leu 
    1550                 1555                 1560             


Cys Glu  Cys Asn Gly His Ser  Asp Leu Cys His Pro  Glu Thr Gly 
    1565                 1570                 1575             


Ala Cys  Ser Gln Cys Gln His  Asn Ala Ala Gly Glu  Phe Cys Glu 
    1580                 1585                 1590             


Leu Cys  Ala Pro Gly Tyr Tyr  Gly Asp Ala Thr Ala  Gly Thr Pro 
    1595                 1600                 1605             


Glu Asp  Cys Gln Pro Cys Ala  Cys Pro Leu Thr Asn  Pro Glu Asn 
    1610                 1615                 1620             


Met Phe  Ser Arg Thr Cys Glu  Ser Leu Gly Ala Gly  Gly Tyr Arg 
    1625                 1630                 1635             


Cys Thr  Ala Cys Glu Pro Gly  Tyr Thr Gly Gln Tyr  Cys Glu Gln 
    1640                 1645                 1650             


Cys Gly  Pro Gly Tyr Val Gly  Asn Pro Ser Val Gln  Gly Gly Gln 
    1655                 1660                 1665             


Cys Leu  Pro Glu Thr Asn Gln  Ala Pro Leu Val Val  Glu Val His 
    1670                 1675                 1680             


Pro Ala  Arg Ser Ile Val Pro  Gln Gly Gly Ser His  Ser Leu Arg 
    1685                 1690                 1695             


Cys Gln  Val Ser Gly Ser Pro  Pro His Tyr Phe Tyr  Trp Ser Arg 
    1700                 1705                 1710             


Glu Asp  Gly Arg Pro Val Pro  Ser Gly Thr Gln Gln  Arg His Gln 
    1715                 1720                 1725             


Gly Ser  Glu Leu His Phe Pro  Ser Val Gln Pro Ser  Asp Ala Gly 
    1730                 1735                 1740             


Val Tyr  Ile Cys Thr Cys Arg  Asn Leu His Gln Ser  Asn Thr Ser 
    1745                 1750                 1755             


Arg Ala  Glu Leu Leu Val Thr  Glu Ala Pro Ser Lys  Pro Ile Thr 
    1760                 1765                 1770             


Val Thr  Val Glu Glu Gln Arg  Ser Gln Ser Val Arg  Pro Gly Ala 
    1775                 1780                 1785             


Asp Val  Thr Phe Ile Cys Thr  Ala Lys Ser Lys Ser  Pro Ala Tyr 
    1790                 1795                 1800             


Thr Leu  Val Trp Thr Arg Leu  His Asn Gly Lys Leu  Pro Thr Arg 
    1805                 1810                 1815             


Ala Met  Asp Phe Asn Gly Ile  Leu Thr Ile Arg Asn  Val Gln Leu 
    1820                 1825                 1830             


Ser Asp  Ala Gly Thr Tyr Val  Cys Thr Gly Ser Asn  Met Phe Ala 
    1835                 1840                 1845             


Met Asp  Gln Gly Thr Ala Thr  Leu His Val Gln Ala  Ser Gly Thr 
    1850                 1855                 1860             


Leu Ser  Ala Pro Val Val Ser  Ile His Pro Pro Gln  Leu Thr Val 
    1865                 1870                 1875             


Gln Pro  Gly Gln Leu Ala Glu  Phe Arg Cys Ser Ala  Thr Gly Ser 
    1880                 1885                 1890             


Pro Thr  Pro Thr Leu Glu Trp  Thr Gly Gly Pro Gly  Gly Gln Leu 
    1895                 1900                 1905             


Pro Ala  Lys Ala Gln Ile His  Gly Gly Ile Leu Arg  Leu Pro Ala 
    1910                 1915                 1920             


Val Glu  Pro Thr Asp Gln Ala  Gln Tyr Leu Cys Arg  Ala His Ser 
    1925                 1930                 1935             


Ser Ala  Gly Gln Gln Val Ala  Arg Ala Val Leu His  Val His Gly 
    1940                 1945                 1950             


Gly Gly  Gly Pro Arg Val Gln  Val Ser Pro Glu Arg  Thr Gln Val 
    1955                 1960                 1965             


His Ala  Gly Arg Thr Val Arg  Leu Tyr Cys Arg Ala  Ala Gly Val 
    1970                 1975                 1980             


Pro Ser  Ala Thr Ile Thr Trp  Arg Lys Glu Gly Gly  Ser Leu Pro 
    1985                 1990                 1995             


Pro Gln  Ala Arg Ser Glu Arg  Thr Asp Ile Ala Thr  Leu Leu Ile 
    2000                 2005                 2010             


Pro Ala  Ile Thr Thr Ala Asp  Ala Gly Phe Tyr Leu  Cys Val Ala 
    2015                 2020                 2025             


Thr Ser  Pro Ala Gly Thr Ala  Gln Ala Arg Ile Gln  Val Val Val 
    2030                 2035                 2040             


Leu Ser  Ala Ser Asp Ala Ser  Pro Pro Pro Val Lys  Ile Glu Ser 
    2045                 2050                 2055             


Ser Ser  Pro Ser Val Thr Glu  Gly Gln Thr Leu Asp  Leu Asn Cys 
    2060                 2065                 2070             


Val Val  Ala Gly Ser Ala His  Ala Gln Val Thr Trp  Tyr Arg Arg 
    2075                 2080                 2085             


Gly Gly  Ser Leu Pro Pro His  Thr Gln Val His Gly  Ser Arg Leu 
    2090                 2095                 2100             


Arg Leu  Pro Gln Val Ser Pro  Ala Asp Ser Gly Glu  Tyr Val Cys 
    2105                 2110                 2115             


Arg Val  Glu Asn Gly Ser Gly  Pro Lys Glu Ala Ser  Ile Thr Val 
    2120                 2125                 2130             


Ser Val  Leu His Gly Thr His  Ser Gly Pro Ser Tyr  Thr Pro Val 
    2135                 2140                 2145             


Pro Gly  Ser Thr Arg Pro Ile  Arg Ile Glu Pro Ser  Ser Ser His 
    2150                 2155                 2160             


Val Ala  Glu Gly Gln Thr Leu  Asp Leu Asn Cys Val  Val Pro Gly 
    2165                 2170                 2175             


Gln Ala  His Ala Gln Val Thr  Trp His Lys Arg Gly  Gly Ser Leu 
    2180                 2185                 2190             


Pro Ala  Arg His Gln Thr His  Gly Ser Leu Leu Arg  Leu His Gln 
    2195                 2200                 2205             


Val Thr  Pro Ala Asp Ser Gly  Glu Tyr Val Cys His  Val Val Gly 
    2210                 2215                 2220             


Thr Ser  Gly Pro Leu Glu Ala  Ser Val Leu Val Thr  Ile Glu Ala 
    2225                 2230                 2235             


Ser Val  Ile Pro Gly Pro Ile  Pro Pro Val Arg Ile  Glu Ser Ser 
    2240                 2245                 2250             


Ser Ser  Thr Val Ala Glu Gly  Gln Thr Leu Asp Leu  Ser Cys Val 
    2255                 2260                 2265             


Val Ala  Gly Gln Ala His Ala  Gln Val Thr Trp Tyr  Lys Arg Gly 
    2270                 2275                 2280             


Gly Ser  Leu Pro Ala Arg His  Gln Val Arg Gly Ser  Arg Leu Tyr 
    2285                 2290                 2295             


Ile Phe  Gln Ala Ser Pro Ala  Asp Ala Gly Gln Tyr  Val Cys Arg 
    2300                 2305                 2310             


Ala Ser  Asn Gly Met Glu Ala  Ser Ile Thr Val Thr  Val Thr Gly 
    2315                 2320                 2325             


Thr Gln  Gly Ala Asn Leu Ala  Tyr Pro Ala Gly Ser  Thr Gln Pro 
    2330                 2335                 2340             


Ile Arg  Ile Glu Pro Ser Ser  Ser Gln Val Ala Glu  Gly Gln Thr 
    2345                 2350                 2355             


Leu Asp  Leu Asn Cys Val Val  Pro Gly Gln Ser His  Ala Gln Val 
    2360                 2365                 2370             


Thr Trp  His Lys Arg Gly Gly  Ser Leu Pro Val Arg  His Gln Thr 
    2375                 2380                 2385             


His Gly  Ser Leu Leu Arg Leu  Tyr Gln Ala Ser Pro  Ala Asp Ser 
    2390                 2395                 2400             


Gly Glu  Tyr Val Cys Arg Val  Leu Gly Ser Ser Val  Pro Leu Glu 
    2405                 2410                 2415             


Ala Ser  Val Leu Val Thr Ile  Glu Pro Ala Gly Ser  Val Pro Ala 
    2420                 2425                 2430             


Leu Gly  Val Thr Pro Thr Val  Arg Ile Glu Ser Ser  Ser Ser Gln 
    2435                 2440                 2445             


Val Ala  Glu Gly Gln Thr Leu  Asp Leu Asn Cys Leu  Val Ala Gly 
    2450                 2455                 2460             


Gln Ala  His Ala Gln Val Thr  Trp His Lys Arg Gly  Gly Ser Leu 
    2465                 2470                 2475             


Pro Ala  Arg His Gln Val His  Gly Ser Arg Leu Arg  Leu Leu Gln 
    2480                 2485                 2490             


Val Thr  Pro Ala Asp Ser Gly  Glu Tyr Val Cys Arg  Val Val Gly 
    2495                 2500                 2505             


Ser Ser  Gly Thr Gln Glu Ala  Ser Val Leu Val Thr  Ile Gln Gln 
    2510                 2515                 2520             


Arg Leu  Ser Gly Ser His Ser  Gln Gly Val Ala Tyr  Pro Val Arg 
    2525                 2530                 2535             


Ile Glu  Ser Ser Ser Ala Ser  Leu Ala Asn Gly His  Thr Leu Asp 
    2540                 2545                 2550             


Leu Asn  Cys Leu Val Ala Ser  Gln Ala Pro His Thr  Ile Thr Trp 
    2555                 2560                 2565             


Tyr Lys  Arg Gly Gly Ser Leu  Pro Ser Arg His Gln  Ile Val Gly 
    2570                 2575                 2580             


Ser Arg  Leu Arg Ile Pro Gln  Val Thr Pro Ala Asp  Ser Gly Glu 
    2585                 2590                 2595             


Tyr Val  Cys His Val Ser Asn  Gly Ala Gly Ser Arg  Glu Thr Ser 
    2600                 2605                 2610             


Leu Ile  Val Thr Ile Gln Gly  Ser Gly Ser Ser His  Val Pro Ser 
    2615                 2620                 2625             


Val Ser  Pro Pro Ile Arg Ile  Glu Ser Ser Ser Pro  Thr Val Val 
    2630                 2635                 2640             


Glu Gly  Gln Thr Leu Asp Leu  Asn Cys Val Val Ala  Arg Gln Pro 
    2645                 2650                 2655             


Gln Ala  Ile Ile Thr Trp Tyr  Lys Arg Gly Gly Ser  Leu Pro Ser 
    2660                 2665                 2670             


Arg His  Gln Thr His Gly Ser  His Leu Arg Leu His  Gln Met Ser 
    2675                 2680                 2685             


Val Ala  Asp Ser Gly Glu Tyr  Val Cys Arg Ala Asn  Asn Asn Ile 
    2690                 2695                 2700             


Asp Ala  Leu Glu Ala Ser Ile  Val Ile Ser Val Ser  Pro Ser Ala 
    2705                 2710                 2715             


Gly Ser  Pro Ser Ala Pro Gly  Ser Ser Met Pro Ile  Arg Ile Glu 
    2720                 2725                 2730             


Ser Ser  Ser Ser His Val Ala  Glu Gly Glu Thr Leu  Asp Leu Asn 
    2735                 2740                 2745             


Cys Val  Val Pro Gly Gln Ala  His Ala Gln Val Thr  Trp His Lys 
    2750                 2755                 2760             


Arg Gly  Gly Ser Leu Pro Ser  His His Gln Thr Arg  Gly Ser Arg 
    2765                 2770                 2775             


Leu Arg  Leu His His Val Ser  Pro Ala Asp Ser Gly  Glu Tyr Val 
    2780                 2785                 2790             


Cys Arg  Val Met Gly Ser Ser  Gly Pro Leu Glu Ala  Ser Val Leu 
    2795                 2800                 2805             


Val Thr  Ile Glu Ala Ser Gly  Ser Ser Ala Val His  Val Pro Ala 
    2810                 2815                 2820             


Pro Gly  Gly Ala Pro Pro Ile  Arg Ile Glu Pro Ser  Ser Ser Arg 
    2825                 2830                 2835             


Val Ala  Glu Gly Gln Thr Leu  Asp Leu Lys Cys Val  Val Pro Gly 
    2840                 2845                 2850             


Gln Ala  His Ala Gln Val Thr  Trp His Lys Arg Gly  Gly Asn Leu 
    2855                 2860                 2865             


Pro Ala  Arg His Gln Val His  Gly Pro Leu Leu Arg  Leu Asn Gln 
    2870                 2875                 2880             


Val Ser  Pro Ala Asp Ser Gly  Glu Tyr Ser Cys Gln  Val Thr Gly 
    2885                 2890                 2895             


Ser Ser  Gly Thr Leu Glu Ala  Ser Val Leu Val Thr  Ile Glu Pro 
    2900                 2905                 2910             


Ser Ser  Pro Gly Pro Ile Pro  Ala Pro Gly Leu Ala  Gln Pro Ile 
    2915                 2920                 2925             


Tyr Ile  Glu Ala Ser Ser Ser  His Val Thr Glu Gly  Gln Thr Leu 
    2930                 2935                 2940             


Asp Leu  Asn Cys Val Val Pro  Gly Gln Ala His Ala  Gln Val Thr 
    2945                 2950                 2955             


Trp Tyr  Lys Arg Gly Gly Ser  Leu Pro Ala Arg His  Gln Thr His 
    2960                 2965                 2970             


Gly Ser  Gln Leu Arg Leu His  Leu Val Ser Pro Ala  Asp Ser Gly 
    2975                 2980                 2985             


Glu Tyr  Val Cys Arg Ala Ala  Ser Gly Pro Gly Pro  Glu Gln Glu 
    2990                 2995                 3000             


Ala Ser  Phe Thr Val Thr Val  Pro Pro Ser Glu Gly  Ser Ser Tyr 
    3005                 3010                 3015             


Arg Leu  Arg Ser Pro Val Ile  Ser Ile Asp Pro Pro  Ser Ser Thr 
    3020                 3025                 3030             


Val Gln  Gln Gly Gln Asp Ala  Ser Phe Lys Cys Leu  Ile His Asp 
    3035                 3040                 3045             


Gly Ala  Ala Pro Ile Ser Leu  Glu Trp Lys Thr Arg  Asn Gln Glu 
    3050                 3055                 3060             


Leu Glu  Asp Asn Val His Ile  Ser Pro Asn Gly Ser  Ile Ile Thr 
    3065                 3070                 3075             


Ile Val  Gly Thr Arg Pro Ser  Asn His Gly Thr Tyr  Arg Cys Val 
    3080                 3085                 3090             


Ala Ser  Asn Ala Tyr Gly Val  Ala Gln Ser Val Val  Asn Leu Ser 
    3095                 3100                 3105             


Val His  Gly Pro Pro Thr Val  Ser Val Leu Pro Glu  Gly Pro Val 
    3110                 3115                 3120             


Trp Val  Lys Val Gly Lys Ala  Val Thr Leu Glu Cys  Val Ser Ala 
    3125                 3130                 3135             


Gly Glu  Pro Arg Ser Ser Ala  Arg Trp Thr Arg Ile  Ser Ser Thr 
    3140                 3145                 3150             


Pro Ala  Lys Leu Glu Gln Arg  Thr Tyr Gly Leu Met  Asp Ser His 
    3155                 3160                 3165             


Ala Val  Leu Gln Ile Ser Ser  Ala Lys Pro Ser Asp  Ala Gly Thr 
    3170                 3175                 3180             


Tyr Val  Cys Leu Ala Gln Asn  Ala Leu Gly Thr Ala  Gln Lys Gln 
    3185                 3190                 3195             


Val Glu  Val Ile Val Asp Thr  Gly Ala Met Ala Pro  Gly Ala Pro 
    3200                 3205                 3210             


Gln Val  Gln Ala Glu Glu Ala  Glu Leu Thr Val Glu  Ala Gly His 
    3215                 3220                 3225             


Thr Ala  Thr Leu Arg Cys Ser  Ala Thr Gly Ser Pro  Ala Pro Thr 
    3230                 3235                 3240             


Ile His  Trp Ser Lys Leu Arg  Ser Pro Leu Pro Trp  Gln His Arg 
    3245                 3250                 3255             


Leu Glu  Gly Asp Thr Leu Ile  Ile Pro Arg Val Ala  Gln Gln Asp 
    3260                 3265                 3270             


Ser Gly  Gln Tyr Ile Cys Asn  Ala Thr Ser Pro Ala  Gly His Ala 
    3275                 3280                 3285             


Glu Ala  Thr Ile Ile Leu His  Val Glu Ser Pro Pro  Tyr Ala Thr 
    3290                 3295                 3300             


Thr Val  Pro Glu His Ala Ser  Val Gln Ala Gly Glu  Thr Val Gln 
    3305                 3310                 3315             


Leu Gln  Cys Leu Ala His Gly  Thr Pro Pro Leu Thr  Phe Gln Trp 
    3320                 3325                 3330             


Ser Arg  Val Gly Ser Ser Leu  Pro Gly Arg Ala Thr  Ala Arg Asn 
    3335                 3340                 3345             


Glu Leu  Leu His Phe Glu Arg  Ala Ala Pro Glu Asp  Ser Gly Arg 
    3350                 3355                 3360             


Tyr Arg  Cys Arg Val Thr Asn  Lys Val Gly Ser Ala  Glu Ala Phe 
    3365                 3370                 3375             


Ala Gln  Leu Leu Val Gln Gly  Pro Pro Gly Ser Leu  Pro Ala Thr 
    3380                 3385                 3390             


Ser Ile  Pro Ala Gly Ser Thr  Pro Thr Val Gln Val  Thr Pro Gln 
    3395                 3400                 3405             


Leu Glu  Thr Lys Ser Ile Gly  Ala Ser Val Glu Phe  His Cys Ala 
    3410                 3415                 3420             


Val Pro  Ser Asp Arg Gly Thr  Gln Leu Arg Trp Phe  Lys Glu Gly 
    3425                 3430                 3435             


Gly Gln  Leu Pro Pro Gly His  Ser Val Gln Asp Gly  Val Leu Arg 
    3440                 3445                 3450             


Ile Gln  Asn Leu Asp Gln Ser  Cys Gln Gly Thr Tyr  Ile Cys Gln 
    3455                 3460                 3465             


Ala His  Gly Pro Trp Gly Lys  Ala Gln Ala Ser Ala  Gln Leu Val 
    3470                 3475                 3480             


Ile Gln  Ala Leu Pro Ser Val  Leu Ile Asn Ile Arg  Thr Ser Val 
    3485                 3490                 3495             


Gln Thr  Val Val Val Gly His  Ala Val Glu Phe Glu  Cys Leu Ala 
    3500                 3505                 3510             


Leu Gly  Asp Pro Lys Pro Gln  Val Thr Trp Ser Lys  Val Gly Gly 
    3515                 3520                 3525             


His Leu  Arg Pro Gly Ile Val  Gln Ser Gly Gly Val  Val Arg Ile 
    3530                 3535                 3540             


Ala His  Val Glu Leu Ala Asp  Ala Gly Gln Tyr Arg  Cys Thr Ala 
    3545                 3550                 3555             


Thr Asn  Ala Ala Gly Thr Thr  Gln Ser His Val Leu  Leu Leu Val 
    3560                 3565                 3570             


Gln Ala  Leu Pro Gln Ile Ser  Met Pro Gln Glu Val  Arg Val Pro 
    3575                 3580                 3585             


Ala Gly  Ser Ala Ala Val Phe  Pro Cys Ile Ala Ser  Gly Tyr Pro 
    3590                 3595                 3600             


Thr Pro  Asp Ile Ser Trp Ser  Lys Leu Asp Gly Ser  Leu Pro Pro 
    3605                 3610                 3615             


Asp Ser  Arg Leu Glu Asn Asn  Met Leu Met Leu Pro  Ser Val Arg 
    3620                 3625                 3630             


Pro Gln  Asp Ala Gly Thr Tyr  Val Cys Thr Ala Thr  Asn Arg Gln 
    3635                 3640                 3645             


Gly Lys  Val Lys Ala Phe Ala  His Leu Gln Val Pro  Glu Arg Val 
    3650                 3655                 3660             


Val Pro  Tyr Phe Thr Gln Thr  Pro Tyr Ser Phe Leu  Pro Leu Pro 
    3665                 3670                 3675             


Thr Ile  Lys Asp Ala Tyr Arg  Lys Phe Glu Ile Lys  Ile Thr Phe 
    3680                 3685                 3690             


Arg Pro  Asp Ser Ala Asp Gly  Met Leu Leu Tyr Asn  Gly Gln Lys 
    3695                 3700                 3705             


Arg Val  Pro Gly Ser Pro Thr  Asn Leu Ala Asn Arg  Gln Pro Asp 
    3710                 3715                 3720             


Phe Ile  Ser Phe Gly Leu Val  Gly Gly Arg Pro Glu  Phe Arg Phe 
    3725                 3730                 3735             


Asp Ala  Gly Ser Gly Met Ala  Thr Ile Arg His Pro  Thr Pro Leu 
    3740                 3745                 3750             


Ala Leu  Gly His Phe His Thr  Val Thr Leu Leu Arg  Ser Leu Thr 
    3755                 3760                 3765             


Gln Gly  Ser Leu Ile Val Gly  Asp Leu Ala Pro Val  Asn Gly Thr 
    3770                 3775                 3780             


Ser Gln  Gly Lys Phe Gln Gly  Leu Asp Leu Asn Glu  Glu Leu Tyr 
    3785                 3790                 3795             


Leu Gly  Gly Tyr Pro Asp Tyr  Gly Ala Ile Pro Lys  Ala Gly Leu 
    3800                 3805                 3810             


Ser Ser  Gly Phe Ile Gly Cys  Val Arg Glu Leu Arg  Ile Gln Gly 
    3815                 3820                 3825             


Glu Glu  Ile Val Phe His Asp  Leu Asn Leu Thr Ala  His Gly Ile 
    3830                 3835                 3840             


Ser His  Cys Pro Thr Cys Arg  Asp Arg Pro Cys Gln  Asn Gly Gly 
    3845                 3850                 3855             


Gln Cys  His Asp Ser Glu Ser  Ser Ser Tyr Val Cys  Val Cys Pro 
    3860                 3865                 3870             


Ala Gly  Phe Thr Gly Ser Arg  Cys Glu His Ser Gln  Ala Leu His 
    3875                 3880                 3885             


Cys His  Pro Glu Ala Cys Gly  Pro Asp Ala Thr Cys  Val Asn Arg 
    3890                 3895                 3900             


Pro Asp  Gly Arg Gly Tyr Thr  Cys Arg Cys His Leu  Gly Arg Ser 
    3905                 3910                 3915             


Gly Leu  Arg Cys Glu Glu Gly  Val Thr Val Thr Thr  Pro Ser Leu 
    3920                 3925                 3930             


Ser Gly  Ala Gly Ser Tyr Leu  Ala Leu Pro Ala Leu  Thr Asn Thr 
    3935                 3940                 3945             


His His  Glu Leu Arg Leu Asp  Val Glu Phe Lys Pro  Leu Ala Pro 
    3950                 3955                 3960             


Asp Gly  Val Leu Leu Phe Ser  Gly Gly Lys Ser Gly  Pro Val Glu 
    3965                 3970                 3975             


Asp Phe  Val Ser Leu Ala Met  Val Gly Gly His Leu  Glu Phe Arg 
    3980                 3985                 3990             


Tyr Glu  Leu Gly Ser Gly Leu  Ala Val Leu Arg Ser  Ala Glu Pro 
    3995                 4000                 4005             


Leu Ala  Leu Gly Arg Trp His  Arg Val Ser Ala Glu  Arg Leu Asn 
    4010                 4015                 4020             


Lys Asp  Gly Ser Leu Arg Val  Asn Gly Gly Arg Pro  Val Leu Arg 
    4025                 4030                 4035             


Ser Ser  Pro Gly Lys Ser Gln  Gly Leu Asn Leu His  Thr Leu Leu 
    4040                 4045                 4050             


Tyr Leu  Gly Gly Val Glu Pro  Ser Val Pro Leu Ser  Pro Ala Thr 
    4055                 4060                 4065             


Asn Met  Ser Ala His Phe Arg  Gly Cys Val Gly Glu  Val Ser Val 
    4070                 4075                 4080             


Asn Gly  Lys Arg Leu Asp Leu  Thr Tyr Ser Phe Leu  Gly Ser Gln 
    4085                 4090                 4095             


Gly Ile  Gly Gln Cys Tyr Asp  Ser Ser Pro Cys Glu  Arg Gln Pro 
    4100                 4105                 4110             


Cys Gln  His Gly Ala Thr Cys  Met Pro Ala Gly Glu  Tyr Glu Phe 
    4115                 4120                 4125             


Gln Cys  Leu Cys Arg Asp Gly  Phe Lys Gly Asp Leu  Cys Glu His 
    4130                 4135                 4140             


Glu Glu  Asn Pro Cys Gln Leu  Arg Glu Pro Cys Leu  His Gly Gly 
    4145                 4150                 4155             


Thr Cys  Gln Gly Thr Arg Cys  Leu Cys Leu Pro Gly  Phe Ser Gly 
    4160                 4165                 4170             


Pro Arg  Cys Gln Gln Gly Ser  Gly His Gly Ile Ala  Glu Ser Asp 
    4175                 4180                 4185             


Trp His  Leu Glu Gly Ser Gly  Gly Asn Asp Ala Pro  Gly Gln Tyr 
    4190                 4195                 4200             


Gly Ala  Tyr Phe His Asp Asp  Gly Phe Leu Ala Phe  Pro Gly His 
    4205                 4210                 4215             


Val Phe  Ser Arg Ser Leu Pro  Glu Val Pro Glu Thr  Ile Glu Leu 
    4220                 4225                 4230             


Glu Val  Arg Thr Ser Thr Ala  Ser Gly Leu Leu Leu  Trp Gln Gly 
    4235                 4240                 4245             


Val Glu  Val Gly Glu Ala Gly  Gln Gly Lys Asp Phe  Ile Ser Leu 
    4250                 4255                 4260             


Gly Leu  Gln Asp Gly His Leu  Val Phe Arg Tyr Gln  Leu Gly Ser 
    4265                 4270                 4275             


Gly Glu  Ala Arg Leu Val Ser  Glu Asp Pro Ile Asn  Asp Gly Glu 
    4280                 4285                 4290             


Trp His  Arg Val Thr Ala Leu  Arg Glu Gly Arg Arg  Gly Ser Ile 
    4295                 4300                 4305             


Gln Val  Asp Gly Glu Glu Leu  Val Ser Gly Arg Ser  Pro Gly Pro 
    4310                 4315                 4320             


Asn Val  Ala Val Asn Ala Lys  Gly Ser Val Tyr Ile  Gly Gly Ala 
    4325                 4330                 4335             


Pro Asp  Val Ala Thr Leu Thr  Gly Gly Arg Phe Ser  Ser Gly Ile 
    4340                 4345                 4350             


Thr Gly  Cys Val Lys Asn Leu  Val Leu His Ser Ala  Arg Pro Gly 
    4355                 4360                 4365             


Ala Pro  Pro Pro Gln Pro Leu  Asp Leu Gln His Arg  Ala Gln Ala 
    4370                 4375                 4380             


Gly Ala  Asn Thr Arg Pro Cys  Pro Ser 
    4385                 4390         


<210>  197
<211>  275
<212>  PRT
<213>  Homo sapiens

<400>  197

Met Ser Ser Phe Gly Tyr Arg Thr Leu Thr Val Ala Leu Phe Thr Leu 
1               5                   10                  15      


Ile Cys Cys Pro Gly Ser Asp Glu Lys Val Phe Glu Val His Val Arg 
            20                  25                  30          


Pro Lys Lys Leu Ala Val Glu Pro Lys Gly Ser Leu Glu Val Asn Cys 
        35                  40                  45              


Ser Thr Thr Cys Asn Gln Pro Glu Val Gly Gly Leu Glu Thr Ser Leu 
    50                  55                  60                  


Asp Lys Ile Leu Leu Asp Glu Gln Ala Gln Trp Lys His Tyr Leu Val 
65                  70                  75                  80  


Ser Asn Ile Ser His Asp Thr Val Leu Gln Cys His Phe Thr Cys Ser 
                85                  90                  95      


Gly Lys Gln Glu Ser Met Asn Ser Asn Val Ser Val Tyr Gln Pro Pro 
            100                 105                 110         


Arg Gln Val Ile Leu Thr Leu Gln Pro Thr Leu Val Ala Val Gly Lys 
        115                 120                 125             


Ser Phe Thr Ile Glu Cys Arg Val Pro Thr Val Glu Pro Leu Asp Ser 
    130                 135                 140                 


Leu Thr Leu Phe Leu Phe Arg Gly Asn Glu Thr Leu His Tyr Glu Thr 
145                 150                 155                 160 


Phe Gly Lys Ala Ala Pro Ala Pro Gln Glu Ala Thr Ala Thr Phe Asn 
                165                 170                 175     


Ser Thr Ala Asp Arg Glu Asp Gly His Arg Asn Phe Ser Cys Leu Ala 
            180                 185                 190         


Val Leu Asp Leu Met Ser Arg Gly Gly Asn Ile Phe His Lys His Ser 
        195                 200                 205             


Ala Pro Lys Met Leu Glu Ile Tyr Glu Pro Val Ser Asp Ser Gln Met 
    210                 215                 220                 


Val Ile Ile Val Thr Val Val Ser Val Leu Leu Ser Leu Phe Val Thr 
225                 230                 235                 240 


Ser Val Leu Leu Cys Phe Ile Phe Gly Gln His Leu Arg Gln Gln Arg 
                245                 250                 255     


Met Gly Thr Tyr Gly Val Arg Ala Ala Trp Arg Arg Leu Pro Gln Ala 
            260                 265                 270         


Phe Arg Pro 
        275 


<210>  198
<211>  2555
<212>  PRT
<213>  Homo sapiens

<400>  198

Met Pro Pro Leu Leu Ala Pro Leu Leu Cys Leu Ala Leu Leu Pro Ala 
1               5                   10                  15      


Leu Ala Ala Arg Gly Pro Arg Cys Ser Gln Pro Gly Glu Thr Cys Leu 
            20                  25                  30          


Asn Gly Gly Lys Cys Glu Ala Ala Asn Gly Thr Glu Ala Cys Val Cys 
        35                  40                  45              


Gly Gly Ala Phe Val Gly Pro Arg Cys Gln Asp Pro Asn Pro Cys Leu 
    50                  55                  60                  


Ser Thr Pro Cys Lys Asn Ala Gly Thr Cys His Val Val Asp Arg Arg 
65                  70                  75                  80  


Gly Val Ala Asp Tyr Ala Cys Ser Cys Ala Leu Gly Phe Ser Gly Pro 
                85                  90                  95      


Leu Cys Leu Thr Pro Leu Asp Asn Ala Cys Leu Thr Asn Pro Cys Arg 
            100                 105                 110         


Asn Gly Gly Thr Cys Asp Leu Leu Thr Leu Thr Glu Tyr Lys Cys Arg 
        115                 120                 125             


Cys Pro Pro Gly Trp Ser Gly Lys Ser Cys Gln Gln Ala Asp Pro Cys 
    130                 135                 140                 


Ala Ser Asn Pro Cys Ala Asn Gly Gly Gln Cys Leu Pro Phe Glu Ala 
145                 150                 155                 160 


Ser Tyr Ile Cys His Cys Pro Pro Ser Phe His Gly Pro Thr Cys Arg 
                165                 170                 175     


Gln Asp Val Asn Glu Cys Gly Gln Lys Pro Gly Leu Cys Arg His Gly 
            180                 185                 190         


Gly Thr Cys His Asn Glu Val Gly Ser Tyr Arg Cys Val Cys Arg Ala 
        195                 200                 205             


Thr His Thr Gly Pro Asn Cys Glu Arg Pro Tyr Val Pro Cys Ser Pro 
    210                 215                 220                 


Ser Pro Cys Gln Asn Gly Gly Thr Cys Arg Pro Thr Gly Asp Val Thr 
225                 230                 235                 240 


His Glu Cys Ala Cys Leu Pro Gly Phe Thr Gly Gln Asn Cys Glu Glu 
                245                 250                 255     


Asn Ile Asp Asp Cys Pro Gly Asn Asn Cys Lys Asn Gly Gly Ala Cys 
            260                 265                 270         


Val Asp Gly Val Asn Thr Tyr Asn Cys Arg Cys Pro Pro Glu Trp Thr 
        275                 280                 285             


Gly Gln Tyr Cys Thr Glu Asp Val Asp Glu Cys Gln Leu Met Pro Asn 
    290                 295                 300                 


Ala Cys Gln Asn Gly Gly Thr Cys His Asn Thr His Gly Gly Tyr Asn 
305                 310                 315                 320 


Cys Val Cys Val Asn Gly Trp Thr Gly Glu Asp Cys Ser Glu Asn Ile 
                325                 330                 335     


Asp Asp Cys Ala Ser Ala Ala Cys Phe His Gly Ala Thr Cys His Asp 
            340                 345                 350         


Arg Val Ala Ser Phe Tyr Cys Glu Cys Pro His Gly Arg Thr Gly Leu 
        355                 360                 365             


Leu Cys His Leu Asn Asp Ala Cys Ile Ser Asn Pro Cys Asn Glu Gly 
    370                 375                 380                 


Ser Asn Cys Asp Thr Asn Pro Val Asn Gly Lys Ala Ile Cys Thr Cys 
385                 390                 395                 400 


Pro Ser Gly Tyr Thr Gly Pro Ala Cys Ser Gln Asp Val Asp Glu Cys 
                405                 410                 415     


Ser Leu Gly Ala Asn Pro Cys Glu His Ala Gly Lys Cys Ile Asn Thr 
            420                 425                 430         


Leu Gly Ser Phe Glu Cys Gln Cys Leu Gln Gly Tyr Thr Gly Pro Arg 
        435                 440                 445             


Cys Glu Ile Asp Val Asn Glu Cys Val Ser Asn Pro Cys Gln Asn Asp 
    450                 455                 460                 


Ala Thr Cys Leu Asp Gln Ile Gly Glu Phe Gln Cys Ile Cys Met Pro 
465                 470                 475                 480 


Gly Tyr Glu Gly Val His Cys Glu Val Asn Thr Asp Glu Cys Ala Ser 
                485                 490                 495     


Ser Pro Cys Leu His Asn Gly Arg Cys Leu Asp Lys Ile Asn Glu Phe 
            500                 505                 510         


Gln Cys Glu Cys Pro Thr Gly Phe Thr Gly His Leu Cys Gln Tyr Asp 
        515                 520                 525             


Val Asp Glu Cys Ala Ser Thr Pro Cys Lys Asn Gly Ala Lys Cys Leu 
    530                 535                 540                 


Asp Gly Pro Asn Thr Tyr Thr Cys Val Cys Thr Glu Gly Tyr Thr Gly 
545                 550                 555                 560 


Thr His Cys Glu Val Asp Ile Asp Glu Cys Asp Pro Asp Pro Cys His 
                565                 570                 575     


Tyr Gly Ser Cys Lys Asp Gly Val Ala Thr Phe Thr Cys Leu Cys Arg 
            580                 585                 590         


Pro Gly Tyr Thr Gly His His Cys Glu Thr Asn Ile Asn Glu Cys Ser 
        595                 600                 605             


Ser Gln Pro Cys Arg His Gly Gly Thr Cys Gln Asp Arg Asp Asn Ala 
    610                 615                 620                 


Tyr Leu Cys Phe Cys Leu Lys Gly Thr Thr Gly Pro Asn Cys Glu Ile 
625                 630                 635                 640 


Asn Leu Asp Asp Cys Ala Ser Ser Pro Cys Asp Ser Gly Thr Cys Leu 
                645                 650                 655     


Asp Lys Ile Asp Gly Tyr Glu Cys Ala Cys Glu Pro Gly Tyr Thr Gly 
            660                 665                 670         


Ser Met Cys Asn Ile Asn Ile Asp Glu Cys Ala Gly Asn Pro Cys His 
        675                 680                 685             


Asn Gly Gly Thr Cys Glu Asp Gly Ile Asn Gly Phe Thr Cys Arg Cys 
    690                 695                 700                 


Pro Glu Gly Tyr His Asp Pro Thr Cys Leu Ser Glu Val Asn Glu Cys 
705                 710                 715                 720 


Asn Ser Asn Pro Cys Val His Gly Ala Cys Arg Asp Ser Leu Asn Gly 
                725                 730                 735     


Tyr Lys Cys Asp Cys Asp Pro Gly Trp Ser Gly Thr Asn Cys Asp Ile 
            740                 745                 750         


Asn Asn Asn Glu Cys Glu Ser Asn Pro Cys Val Asn Gly Gly Thr Cys 
        755                 760                 765             


Lys Asp Met Thr Ser Gly Tyr Val Cys Thr Cys Arg Glu Gly Phe Ser 
    770                 775                 780                 


Gly Pro Asn Cys Gln Thr Asn Ile Asn Glu Cys Ala Ser Asn Pro Cys 
785                 790                 795                 800 


Leu Asn Gln Gly Thr Cys Ile Asp Asp Val Ala Gly Tyr Lys Cys Asn 
                805                 810                 815     


Cys Leu Leu Pro Tyr Thr Gly Ala Thr Cys Glu Val Val Leu Ala Pro 
            820                 825                 830         


Cys Ala Pro Ser Pro Cys Arg Asn Gly Gly Glu Cys Arg Gln Ser Glu 
        835                 840                 845             


Asp Tyr Glu Ser Phe Ser Cys Val Cys Pro Thr Gly Trp Gln Gly Gln 
    850                 855                 860                 


Thr Cys Glu Val Asp Ile Asn Glu Cys Val Leu Ser Pro Cys Arg His 
865                 870                 875                 880 


Gly Ala Ser Cys Gln Asn Thr His Gly Gly Tyr Arg Cys His Cys Gln 
                885                 890                 895     


Ala Gly Tyr Ser Gly Arg Asn Cys Glu Thr Asp Ile Asp Asp Cys Arg 
            900                 905                 910         


Pro Asn Pro Cys His Asn Gly Gly Ser Cys Thr Asp Gly Ile Asn Thr 
        915                 920                 925             


Ala Phe Cys Asp Cys Leu Pro Gly Phe Arg Gly Thr Phe Cys Glu Glu 
    930                 935                 940                 


Asp Ile Asn Glu Cys Ala Ser Asp Pro Cys Arg Asn Gly Ala Asn Cys 
945                 950                 955                 960 


Thr Asp Cys Val Asp Ser Tyr Thr Cys Thr Cys Pro Ala Gly Phe Ser 
                965                 970                 975     


Gly Ile His Cys Glu Asn Asn Thr Pro Asp Cys Thr Glu Ser Ser Cys 
            980                 985                 990         


Phe Asn Gly Gly Thr Cys Val Asp  Gly Ile Asn Ser Phe  Thr Cys Leu 
        995                 1000                 1005             


Cys Pro  Pro Gly Phe Thr Gly  Ser Tyr Cys Gln His  Asp Val Asn 
    1010                 1015                 1020             


Glu Cys  Asp Ser Gln Pro Cys  Leu His Gly Gly Thr  Cys Gln Asp 
    1025                 1030                 1035             


Gly Cys  Gly Ser Tyr Arg Cys  Thr Cys Pro Gln Gly  Tyr Thr Gly 
    1040                 1045                 1050             


Pro Asn  Cys Gln Asn Leu Val  His Trp Cys Asp Ser  Ser Pro Cys 
    1055                 1060                 1065             


Lys Asn  Gly Gly Lys Cys Trp  Gln Thr His Thr Gln  Tyr Arg Cys 
    1070                 1075                 1080             


Glu Cys  Pro Ser Gly Trp Thr  Gly Leu Tyr Cys Asp  Val Pro Ser 
    1085                 1090                 1095             


Val Ser  Cys Glu Val Ala Ala  Gln Arg Gln Gly Val  Asp Val Ala 
    1100                 1105                 1110             


Arg Leu  Cys Gln His Gly Gly  Leu Cys Val Asp Ala  Gly Asn Thr 
    1115                 1120                 1125             


His His  Cys Arg Cys Gln Ala  Gly Tyr Thr Gly Ser  Tyr Cys Glu 
    1130                 1135                 1140             


Asp Leu  Val Asp Glu Cys Ser  Pro Ser Pro Cys Gln  Asn Gly Ala 
    1145                 1150                 1155             


Thr Cys  Thr Asp Tyr Leu Gly  Gly Tyr Ser Cys Lys  Cys Val Ala 
    1160                 1165                 1170             


Gly Tyr  His Gly Val Asn Cys  Ser Glu Glu Ile Asp  Glu Cys Leu 
    1175                 1180                 1185             


Ser His  Pro Cys Gln Asn Gly  Gly Thr Cys Leu Asp  Leu Pro Asn 
    1190                 1195                 1200             


Thr Tyr  Lys Cys Ser Cys Pro  Arg Gly Thr Gln Gly  Val His Cys 
    1205                 1210                 1215             


Glu Ile  Asn Val Asp Asp Cys  Asn Pro Pro Val Asp  Pro Val Ser 
    1220                 1225                 1230             


Arg Ser  Pro Lys Cys Phe Asn  Asn Gly Thr Cys Val  Asp Gln Val 
    1235                 1240                 1245             


Gly Gly  Tyr Ser Cys Thr Cys  Pro Pro Gly Phe Val  Gly Glu Arg 
    1250                 1255                 1260             


Cys Glu  Gly Asp Val Asn Glu  Cys Leu Ser Asn Pro  Cys Asp Ala 
    1265                 1270                 1275             


Arg Gly  Thr Gln Asn Cys Val  Gln Arg Val Asn Asp  Phe His Cys 
    1280                 1285                 1290             


Glu Cys  Arg Ala Gly His Thr  Gly Arg Arg Cys Glu  Ser Val Ile 
    1295                 1300                 1305             


Asn Gly  Cys Lys Gly Lys Pro  Cys Lys Asn Gly Gly  Thr Cys Ala 
    1310                 1315                 1320             


Val Ala  Ser Asn Thr Ala Arg  Gly Phe Ile Cys Lys  Cys Pro Ala 
    1325                 1330                 1335             


Gly Phe  Glu Gly Ala Thr Cys  Glu Asn Asp Ala Arg  Thr Cys Gly 
    1340                 1345                 1350             


Ser Leu  Arg Cys Leu Asn Gly  Gly Thr Cys Ile Ser  Gly Pro Arg 
    1355                 1360                 1365             


Ser Pro  Thr Cys Leu Cys Leu  Gly Pro Phe Thr Gly  Pro Glu Cys 
    1370                 1375                 1380             


Gln Phe  Pro Ala Ser Ser Pro  Cys Leu Gly Gly Asn  Pro Cys Tyr 
    1385                 1390                 1395             


Asn Gln  Gly Thr Cys Glu Pro  Thr Ser Glu Ser Pro  Phe Tyr Arg 
    1400                 1405                 1410             


Cys Leu  Cys Pro Ala Lys Phe  Asn Gly Leu Leu Cys  His Ile Leu 
    1415                 1420                 1425             


Asp Tyr  Ser Phe Gly Gly Gly  Ala Gly Arg Asp Ile  Pro Pro Pro 
    1430                 1435                 1440             


Leu Ile  Glu Glu Ala Cys Glu  Leu Pro Glu Cys Gln  Glu Asp Ala 
    1445                 1450                 1455             


Gly Asn  Lys Val Cys Ser Leu  Gln Cys Asn Asn His  Ala Cys Gly 
    1460                 1465                 1470             


Trp Asp  Gly Gly Asp Cys Ser  Leu Asn Phe Asn Asp  Pro Trp Lys 
    1475                 1480                 1485             


Asn Cys  Thr Gln Ser Leu Gln  Cys Trp Lys Tyr Phe  Ser Asp Gly 
    1490                 1495                 1500             


His Cys  Asp Ser Gln Cys Asn  Ser Ala Gly Cys Leu  Phe Asp Gly 
    1505                 1510                 1515             


Phe Asp  Cys Gln Arg Ala Glu  Gly Gln Cys Asn Pro  Leu Tyr Asp 
    1520                 1525                 1530             


Gln Tyr  Cys Lys Asp His Phe  Ser Asp Gly His Cys  Asp Gln Gly 
    1535                 1540                 1545             


Cys Asn  Ser Ala Glu Cys Glu  Trp Asp Gly Leu Asp  Cys Ala Glu 
    1550                 1555                 1560             


His Val  Pro Glu Arg Leu Ala  Ala Gly Thr Leu Val  Val Val Val 
    1565                 1570                 1575             


Leu Met  Pro Pro Glu Gln Leu  Arg Asn Ser Ser Phe  His Phe Leu 
    1580                 1585                 1590             


Arg Glu  Leu Ser Arg Val Leu  His Thr Asn Val Val  Phe Lys Arg 
    1595                 1600                 1605             


Asp Ala  His Gly Gln Gln Met  Ile Phe Pro Tyr Tyr  Gly Arg Glu 
    1610                 1615                 1620             


Glu Glu  Leu Arg Lys His Pro  Ile Lys Arg Ala Ala  Glu Gly Trp 
    1625                 1630                 1635             


Ala Ala  Pro Asp Ala Leu Leu  Gly Gln Val Lys Ala  Ser Leu Leu 
    1640                 1645                 1650             


Pro Gly  Gly Ser Glu Gly Gly  Arg Arg Arg Arg Glu  Leu Asp Pro 
    1655                 1660                 1665             


Met Asp  Val Arg Gly Ser Ile  Val Tyr Leu Glu Ile  Asp Asn Arg 
    1670                 1675                 1680             


Gln Cys  Val Gln Ala Ser Ser  Gln Cys Phe Gln Ser  Ala Thr Asp 
    1685                 1690                 1695             


Val Ala  Ala Phe Leu Gly Ala  Leu Ala Ser Leu Gly  Ser Leu Asn 
    1700                 1705                 1710             


Ile Pro  Tyr Lys Ile Glu Ala  Val Gln Ser Glu Thr  Val Glu Pro 
    1715                 1720                 1725             


Pro Pro  Pro Ala Gln Leu His  Phe Met Tyr Val Ala  Ala Ala Ala 
    1730                 1735                 1740             


Phe Val  Leu Leu Phe Phe Val  Gly Cys Gly Val Leu  Leu Ser Arg 
    1745                 1750                 1755             


Lys Arg  Arg Arg Gln His Gly  Gln Leu Trp Phe Pro  Glu Gly Phe 
    1760                 1765                 1770             


Lys Val  Ser Glu Ala Ser Lys  Lys Lys Arg Arg Glu  Pro Leu Gly 
    1775                 1780                 1785             


Glu Asp  Ser Val Gly Leu Lys  Pro Leu Lys Asn Ala  Ser Asp Gly 
    1790                 1795                 1800             


Ala Leu  Met Asp Asp Asn Gln  Asn Glu Trp Gly Asp  Glu Asp Leu 
    1805                 1810                 1815             


Glu Thr  Lys Lys Phe Arg Phe  Glu Glu Pro Val Val  Leu Pro Asp 
    1820                 1825                 1830             


Leu Asp  Asp Gln Thr Asp His  Arg Gln Trp Thr Gln  Gln His Leu 
    1835                 1840                 1845             


Asp Ala  Ala Asp Leu Arg Met  Ser Ala Met Ala Pro  Thr Pro Pro 
    1850                 1855                 1860             


Gln Gly  Glu Val Asp Ala Asp  Cys Met Asp Val Asn  Val Arg Gly 
    1865                 1870                 1875             


Pro Asp  Gly Phe Thr Pro Leu  Met Ile Ala Ser Cys  Ser Gly Gly 
    1880                 1885                 1890             


Gly Leu  Glu Thr Gly Asn Ser  Glu Glu Glu Glu Asp  Ala Pro Ala 
    1895                 1900                 1905             


Val Ile  Ser Asp Phe Ile Tyr  Gln Gly Ala Ser Leu  His Asn Gln 
    1910                 1915                 1920             


Thr Asp  Arg Thr Gly Glu Thr  Ala Leu His Leu Ala  Ala Arg Tyr 
    1925                 1930                 1935             


Ser Arg  Ser Asp Ala Ala Lys  Arg Leu Leu Glu Ala  Ser Ala Asp 
    1940                 1945                 1950             


Ala Asn  Ile Gln Asp Asn Met  Gly Arg Thr Pro Leu  His Ala Ala 
    1955                 1960                 1965             


Val Ser  Ala Asp Ala Gln Gly  Val Phe Gln Ile Leu  Ile Arg Asn 
    1970                 1975                 1980             


Arg Ala  Thr Asp Leu Asp Ala  Arg Met His Asp Gly  Thr Thr Pro 
    1985                 1990                 1995             


Leu Ile  Leu Ala Ala Arg Leu  Ala Val Glu Gly Met  Leu Glu Asp 
    2000                 2005                 2010             


Leu Ile  Asn Ser His Ala Asp  Val Asn Ala Val Asp  Asp Leu Gly 
    2015                 2020                 2025             


Lys Ser  Ala Leu His Trp Ala  Ala Ala Val Asn Asn  Val Asp Ala 
    2030                 2035                 2040             


Ala Val  Val Leu Leu Lys Asn  Gly Ala Asn Lys Asp  Met Gln Asn 
    2045                 2050                 2055             


Asn Arg  Glu Glu Thr Pro Leu  Phe Leu Ala Ala Arg  Glu Gly Ser 
    2060                 2065                 2070             


Tyr Glu  Thr Ala Lys Val Leu  Leu Asp His Phe Ala  Asn Arg Asp 
    2075                 2080                 2085             


Ile Thr  Asp His Met Asp Arg  Leu Pro Arg Asp Ile  Ala Gln Glu 
    2090                 2095                 2100             


Arg Met  His His Asp Ile Val  Arg Leu Leu Asp Glu  Tyr Asn Leu 
    2105                 2110                 2115             


Val Arg  Ser Pro Gln Leu His  Gly Ala Pro Leu Gly  Gly Thr Pro 
    2120                 2125                 2130             


Thr Leu  Ser Pro Pro Leu Cys  Ser Pro Asn Gly Tyr  Leu Gly Ser 
    2135                 2140                 2145             


Leu Lys  Pro Gly Val Gln Gly  Lys Lys Val Arg Lys  Pro Ser Ser 
    2150                 2155                 2160             


Lys Gly  Leu Ala Cys Gly Ser  Lys Glu Ala Lys Asp  Leu Lys Ala 
    2165                 2170                 2175             


Arg Arg  Lys Lys Ser Gln Asp  Gly Lys Gly Cys Leu  Leu Asp Ser 
    2180                 2185                 2190             


Ser Gly  Met Leu Ser Pro Val  Asp Ser Leu Glu Ser  Pro His Gly 
    2195                 2200                 2205             


Tyr Leu  Ser Asp Val Ala Ser  Pro Pro Leu Leu Pro  Ser Pro Phe 
    2210                 2215                 2220             


Gln Gln  Ser Pro Ser Val Pro  Leu Asn His Leu Pro  Gly Met Pro 
    2225                 2230                 2235             


Asp Thr  His Leu Gly Ile Gly  His Leu Asn Val Ala  Ala Lys Pro 
    2240                 2245                 2250             


Glu Met  Ala Ala Leu Gly Gly  Gly Gly Arg Leu Ala  Phe Glu Thr 
    2255                 2260                 2265             


Gly Pro  Pro Arg Leu Ser His  Leu Pro Val Ala Ser  Gly Thr Ser 
    2270                 2275                 2280             


Thr Val  Leu Gly Ser Ser Ser  Gly Gly Ala Leu Asn  Phe Thr Val 
    2285                 2290                 2295             


Gly Gly  Ser Thr Ser Leu Asn  Gly Gln Cys Glu Trp  Leu Ser Arg 
    2300                 2305                 2310             


Leu Gln  Ser Gly Met Val Pro  Asn Gln Tyr Asn Pro  Leu Arg Gly 
    2315                 2320                 2325             


Ser Val  Ala Pro Gly Pro Leu  Ser Thr Gln Ala Pro  Ser Leu Gln 
    2330                 2335                 2340             


His Gly  Met Val Gly Pro Leu  His Ser Ser Leu Ala  Ala Ser Ala 
    2345                 2350                 2355             


Leu Ser  Gln Met Met Ser Tyr  Gln Gly Leu Pro Ser  Thr Arg Leu 
    2360                 2365                 2370             


Ala Thr  Gln Pro His Leu Val  Gln Thr Gln Gln Val  Gln Pro Gln 
    2375                 2380                 2385             


Asn Leu  Gln Met Gln Gln Gln  Asn Leu Gln Pro Ala  Asn Ile Gln 
    2390                 2395                 2400             


Gln Gln  Gln Ser Leu Gln Pro  Pro Pro Pro Pro Pro  Gln Pro His 
    2405                 2410                 2415             


Leu Gly  Val Ser Ser Ala Ala  Ser Gly His Leu Gly  Arg Ser Phe 
    2420                 2425                 2430             


Leu Ser  Gly Glu Pro Ser Gln  Ala Asp Val Gln Pro  Leu Gly Pro 
    2435                 2440                 2445             


Ser Ser  Leu Ala Val His Thr  Ile Leu Pro Gln Glu  Ser Pro Ala 
    2450                 2455                 2460             


Leu Pro  Thr Ser Leu Pro Ser  Ser Leu Val Pro Pro  Val Thr Ala 
    2465                 2470                 2475             


Ala Gln  Phe Leu Thr Pro Pro  Ser Gln His Ser Tyr  Ser Ser Pro 
    2480                 2485                 2490             


Val Asp  Asn Thr Pro Ser His  Gln Leu Gln Val Pro  Glu His Pro 
    2495                 2500                 2505             


Phe Leu  Thr Pro Ser Pro Glu  Ser Pro Asp Gln Trp  Ser Ser Ser 
    2510                 2515                 2520             


Ser Pro  His Ser Asn Val Ser  Asp Trp Ser Glu Gly  Val Ser Ser 
    2525                 2530                 2535             


Pro Pro  Thr Ser Met Gln Ser  Gln Ile Ala Arg Ile  Pro Glu Ala 
    2540                 2545                 2550             


Phe Lys  
    2555 


<210>  199
<211>  1235
<212>  PRT
<213>  Homo sapiens

<400>  199

Met Pro Ala Leu Arg Pro Ala Leu Leu Trp Ala Leu Leu Ala Leu Trp 
1               5                   10                  15      


Leu Cys Cys Ala Ala Pro Ala His Ala Leu Gln Cys Arg Asp Gly Tyr 
            20                  25                  30          


Glu Pro Cys Val Asn Glu Gly Met Cys Val Thr Tyr His Asn Gly Thr 
        35                  40                  45              


Gly Tyr Cys Lys Cys Pro Glu Gly Phe Leu Gly Glu Tyr Cys Gln His 
    50                  55                  60                  


Arg Asp Pro Cys Glu Lys Asn Arg Cys Gln Asn Gly Gly Thr Cys Val 
65                  70                  75                  80  


Ala Gln Ala Met Leu Gly Lys Ala Thr Cys Arg Cys Ala Ser Gly Phe 
                85                  90                  95      


Thr Gly Glu Asp Cys Gln Tyr Ser Thr Ser His Pro Cys Phe Val Ser 
            100                 105                 110         


Arg Pro Cys Leu Asn Gly Gly Thr Cys His Met Leu Ser Arg Asp Thr 
        115                 120                 125             


Tyr Glu Cys Thr Cys Gln Val Gly Phe Thr Gly Lys Glu Cys Gln Trp 
    130                 135                 140                 


Thr Asp Ala Cys Leu Ser His Pro Cys Ala Asn Gly Ser Thr Cys Thr 
145                 150                 155                 160 


Thr Val Ala Asn Gln Phe Ser Cys Lys Cys Leu Thr Gly Phe Thr Gly 
                165                 170                 175     


Gln Lys Cys Glu Thr Asp Val Asn Glu Cys Asp Ile Pro Gly His Cys 
            180                 185                 190         


Gln His Gly Gly Thr Cys Leu Asn Leu Pro Gly Ser Tyr Gln Cys Gln 
        195                 200                 205             


Cys Pro Gln Gly Phe Thr Gly Gln Tyr Cys Asp Ser Leu Tyr Val Pro 
    210                 215                 220                 


Cys Ala Pro Ser Pro Cys Val Asn Gly Gly Thr Cys Arg Gln Thr Gly 
225                 230                 235                 240 


Asp Phe Thr Phe Glu Cys Asn Cys Leu Pro Gly Phe Glu Gly Ser Thr 
                245                 250                 255     


Cys Glu Arg Asn Ile Asp Asp Cys Pro Asn His Arg Cys Gln Asn Gly 
            260                 265                 270         


Gly Val Cys Val Asp Gly Val Asn Thr Tyr Asn Cys Arg Cys Pro Pro 
        275                 280                 285             


Gln Trp Thr Gly Gln Phe Cys Thr Glu Asp Val Asp Glu Cys Leu Leu 
    290                 295                 300                 


Gln Pro Asn Ala Cys Gln Asn Gly Gly Thr Cys Ala Asn Arg Asn Gly 
305                 310                 315                 320 


Gly Tyr Gly Cys Val Cys Val Asn Gly Trp Ser Gly Asp Asp Cys Ser 
                325                 330                 335     


Glu Asn Ile Asp Asp Cys Ala Phe Ala Ser Cys Thr Pro Gly Ser Thr 
            340                 345                 350         


Cys Ile Asp Arg Val Ala Ser Phe Ser Cys Met Cys Pro Glu Gly Lys 
        355                 360                 365             


Ala Gly Leu Leu Cys His Leu Asp Asp Ala Cys Ile Ser Asn Pro Cys 
    370                 375                 380                 


His Lys Gly Ala Leu Cys Asp Thr Asn Pro Leu Asn Gly Gln Tyr Ile 
385                 390                 395                 400 


Cys Thr Cys Pro Gln Gly Tyr Lys Gly Ala Asp Cys Thr Glu Asp Val 
                405                 410                 415     


Asp Glu Cys Ala Met Ala Asn Ser Asn Pro Cys Glu His Ala Gly Lys 
            420                 425                 430         


Cys Val Asn Thr Asp Gly Ala Phe His Cys Glu Cys Leu Lys Gly Tyr 
        435                 440                 445             


Ala Gly Pro Arg Cys Glu Met Asp Ile Asn Glu Cys His Ser Asp Pro 
    450                 455                 460                 


Cys Gln Asn Asp Ala Thr Cys Leu Asp Lys Ile Gly Gly Phe Thr Cys 
465                 470                 475                 480 


Leu Cys Met Pro Gly Phe Lys Gly Val His Cys Glu Leu Glu Ile Asn 
                485                 490                 495     


Glu Cys Gln Ser Asn Pro Cys Val Asn Asn Gly Gln Cys Val Asp Lys 
            500                 505                 510         


Val Asn Arg Phe Gln Cys Leu Cys Pro Pro Gly Phe Thr Gly Pro Val 
        515                 520                 525             


Cys Gln Ile Asp Ile Asp Asp Cys Ser Ser Thr Pro Cys Leu Asn Gly 
    530                 535                 540                 


Ala Lys Cys Ile Asp His Pro Asn Gly Tyr Glu Cys Gln Cys Ala Thr 
545                 550                 555                 560 


Gly Phe Thr Gly Val Leu Cys Glu Glu Asn Ile Asp Asn Cys Asp Pro 
                565                 570                 575     


Asp Pro Cys His His Gly Gln Cys Gln Asp Gly Ile Asp Ser Tyr Thr 
            580                 585                 590         


Cys Ile Cys Asn Pro Gly Tyr Met Gly Ala Ile Cys Ser Asp Gln Ile 
        595                 600                 605             


Asp Glu Cys Tyr Ser Ser Pro Cys Leu Asn Asp Gly Arg Cys Ile Asp 
    610                 615                 620                 


Leu Val Asn Gly Tyr Gln Cys Asn Cys Gln Pro Gly Thr Ser Gly Val 
625                 630                 635                 640 


Asn Cys Glu Ile Asn Phe Asp Asp Cys Ala Ser Asn Pro Cys Ile His 
                645                 650                 655     


Gly Ile Cys Met Asp Gly Ile Asn Arg Tyr Ser Cys Val Cys Ser Pro 
            660                 665                 670         


Gly Phe Thr Gly Gln Arg Cys Asn Ile Asp Ile Asp Glu Cys Ala Ser 
        675                 680                 685             


Asn Pro Cys Arg Lys Gly Ala Thr Cys Ile Asn Gly Val Asn Gly Phe 
    690                 695                 700                 


Arg Cys Ile Cys Pro Glu Gly Pro His His Pro Ser Cys Tyr Ser Gln 
705                 710                 715                 720 


Val Asn Glu Cys Leu Ser Asn Pro Cys Ile His Gly Asn Cys Thr Gly 
                725                 730                 735     


Gly Leu Ser Gly Tyr Lys Cys Leu Cys Asp Ala Gly Trp Val Gly Ile 
            740                 745                 750         


Asn Cys Glu Val Asp Lys Asn Glu Cys Leu Ser Asn Pro Cys Gln Asn 
        755                 760                 765             


Gly Gly Thr Cys Asp Asn Leu Val Asn Gly Tyr Arg Cys Thr Cys Lys 
    770                 775                 780                 


Lys Gly Phe Lys Gly Tyr Asn Cys Gln Val Asn Ile Asp Glu Cys Ala 
785                 790                 795                 800 


Ser Asn Pro Cys Leu Asn Gln Gly Thr Cys Phe Asp Asp Ile Ser Gly 
                805                 810                 815     


Tyr Thr Cys His Cys Val Leu Pro Tyr Thr Gly Lys Asn Cys Gln Thr 
            820                 825                 830         


Val Leu Ala Pro Cys Ser Pro Asn Pro Cys Glu Asn Ala Ala Val Cys 
        835                 840                 845             


Lys Glu Ser Pro Asn Phe Glu Ser Tyr Thr Cys Leu Cys Ala Pro Gly 
    850                 855                 860                 


Trp Gln Gly Gln Arg Cys Thr Ile Asp Ile Asp Glu Cys Ile Ser Lys 
865                 870                 875                 880 


Pro Cys Met Asn His Gly Leu Cys His Asn Thr Gln Gly Ser Tyr Met 
                885                 890                 895     


Cys Glu Cys Pro Pro Gly Phe Ser Gly Met Asp Cys Glu Glu Asp Ile 
            900                 905                 910         


Asp Asp Cys Leu Ala Asn Pro Cys Gln Asn Gly Gly Ser Cys Met Asp 
        915                 920                 925             


Gly Val Asn Thr Phe Ser Cys Leu Cys Leu Pro Gly Phe Thr Gly Asp 
    930                 935                 940                 


Lys Cys Gln Thr Asp Met Asn Glu Cys Leu Ser Glu Pro Cys Lys Asn 
945                 950                 955                 960 


Gly Gly Thr Cys Ser Asp Tyr Val Asn Ser Tyr Thr Cys Lys Cys Gln 
                965                 970                 975     


Ala Gly Phe Asp Gly Val His Cys Glu Asn Asn Ile Asn Glu Cys Thr 
            980                 985                 990         


Glu Ser Ser Cys Phe Asn Gly Gly  Thr Cys Val Asp Gly  Ile Asn Ser 
        995                 1000                 1005             


Phe Ser  Cys Leu Cys Pro Val  Gly Phe Thr Gly Ser  Phe Cys Leu 
    1010                 1015                 1020             


His Glu  Ile Asn Glu Cys Ser  Ser His Pro Cys Leu  Asn Glu Gly 
    1025                 1030                 1035             


Thr Cys  Val Asp Gly Leu Gly  Thr Tyr Arg Cys Ser  Cys Pro Leu 
    1040                 1045                 1050             


Gly Tyr  Thr Gly Lys Asn Cys  Gln Thr Leu Val Asn  Leu Cys Ser 
    1055                 1060                 1065             


Arg Ser  Pro Cys Lys Asn Lys  Gly Thr Cys Val Gln  Lys Lys Ala 
    1070                 1075                 1080             


Glu Ser  Gln Cys Leu Cys Pro  Ser Gly Trp Ala Gly  Ala Tyr Cys 
    1085                 1090                 1095             


Asp Val  Pro Asn Val Ser Cys  Asp Ile Ala Ala Ser  Arg Arg Gly 
    1100                 1105                 1110             


Val Leu  Val Glu His Leu Cys  Gln His Ser Gly Val  Cys Ile Asn 
    1115                 1120                 1125             


Ala Gly  Asn Thr His Tyr Cys  Gln Cys Pro Leu Gly  Tyr Thr Gly 
    1130                 1135                 1140             


Ser Tyr  Cys Glu Glu Gln Leu  Asp Glu Cys Ala Ser  Asn Pro Cys 
    1145                 1150                 1155             


Gln His  Gly Ala Thr Cys Ser  Asp Phe Ile Gly Gly  Tyr Arg Cys 
    1160                 1165                 1170             


Glu Cys  Val Pro Gly Tyr Gln  Gly Val Asn Cys Glu  Tyr Glu Val 
    1175                 1180                 1185             


Asp Glu  Cys Gln Asn Gln Pro  Cys Gln Asn Gly Gly  Thr Cys Ile 
    1190                 1195                 1200             


Asp Leu  Val Asn His Phe Lys  Cys Ser Cys Pro Pro  Gly Thr Arg 
    1205                 1210                 1215             


Gly Met  Lys Ser Ser Leu Ser  Ile Phe His Pro Gly  His Cys Leu 
    1220                 1225                 1230             


Lys Leu  
    1235 


<210>  200
<211>  2321
<212>  PRT
<213>  Homo sapiens

<400>  200

Met Gly Pro Gly Ala Arg Gly Arg Arg Arg Arg Arg Arg Pro Met Ser 
1               5                   10                  15      


Pro Pro Pro Pro Pro Pro Pro Val Arg Ala Leu Pro Leu Leu Leu Leu 
            20                  25                  30          


Leu Ala Gly Pro Gly Ala Ala Ala Pro Pro Cys Leu Asp Gly Ser Pro 
        35                  40                  45              


Cys Ala Asn Gly Gly Arg Cys Thr Gln Leu Pro Ser Arg Glu Ala Ala 
    50                  55                  60                  


Cys Leu Cys Pro Pro Gly Trp Val Gly Glu Arg Cys Gln Leu Glu Asp 
65                  70                  75                  80  


Pro Cys His Ser Gly Pro Cys Ala Gly Arg Gly Val Cys Gln Ser Ser 
                85                  90                  95      


Val Val Ala Gly Thr Ala Arg Phe Ser Cys Arg Cys Pro Arg Gly Phe 
            100                 105                 110         


Arg Gly Pro Asp Cys Ser Leu Pro Asp Pro Cys Leu Ser Ser Pro Cys 
        115                 120                 125             


Ala His Gly Ala Arg Cys Ser Val Gly Pro Asp Gly Arg Phe Leu Cys 
    130                 135                 140                 


Ser Cys Pro Pro Gly Tyr Gln Gly Arg Ser Cys Arg Ser Asp Val Asp 
145                 150                 155                 160 


Glu Cys Arg Val Gly Glu Pro Cys Arg His Gly Gly Thr Cys Leu Asn 
                165                 170                 175     


Thr Pro Gly Ser Phe Arg Cys Gln Cys Pro Ala Gly Tyr Thr Gly Pro 
            180                 185                 190         


Leu Cys Glu Asn Pro Ala Val Pro Cys Ala Pro Ser Pro Cys Arg Asn 
        195                 200                 205             


Gly Gly Thr Cys Arg Gln Ser Gly Asp Leu Thr Tyr Asp Cys Ala Cys 
    210                 215                 220                 


Leu Pro Gly Phe Glu Gly Gln Asn Cys Glu Val Asn Val Asp Asp Cys 
225                 230                 235                 240 


Pro Gly His Arg Cys Leu Asn Gly Gly Thr Cys Val Asp Gly Val Asn 
                245                 250                 255     


Thr Tyr Asn Cys Gln Cys Pro Pro Glu Trp Thr Gly Gln Phe Cys Thr 
            260                 265                 270         


Glu Asp Val Asp Glu Cys Gln Leu Gln Pro Asn Ala Cys His Asn Gly 
        275                 280                 285             


Gly Thr Cys Phe Asn Thr Leu Gly Gly His Ser Cys Val Cys Val Asn 
    290                 295                 300                 


Gly Trp Thr Gly Glu Ser Cys Ser Gln Asn Ile Asp Asp Cys Ala Thr 
305                 310                 315                 320 


Ala Val Cys Phe His Gly Ala Thr Cys His Asp Arg Val Ala Ser Phe 
                325                 330                 335     


Tyr Cys Ala Cys Pro Met Gly Lys Thr Gly Leu Leu Cys His Leu Asp 
            340                 345                 350         


Asp Ala Cys Val Ser Asn Pro Cys His Glu Asp Ala Ile Cys Asp Thr 
        355                 360                 365             


Asn Pro Val Asn Gly Arg Ala Ile Cys Thr Cys Pro Pro Gly Phe Thr 
    370                 375                 380                 


Gly Gly Ala Cys Asp Gln Asp Val Asp Glu Cys Ser Ile Gly Ala Asn 
385                 390                 395                 400 


Pro Cys Glu His Leu Gly Arg Cys Val Asn Thr Gln Gly Ser Phe Leu 
                405                 410                 415     


Cys Gln Cys Gly Arg Gly Tyr Thr Gly Pro Arg Cys Glu Thr Asp Val 
            420                 425                 430         


Asn Glu Cys Leu Ser Gly Pro Cys Arg Asn Gln Ala Thr Cys Leu Asp 
        435                 440                 445             


Arg Ile Gly Gln Phe Thr Cys Ile Cys Met Ala Gly Phe Thr Gly Thr 
    450                 455                 460                 


Tyr Cys Glu Val Asp Ile Asp Glu Cys Gln Ser Ser Pro Cys Val Asn 
465                 470                 475                 480 


Gly Gly Val Cys Lys Asp Arg Val Asn Gly Phe Ser Cys Thr Cys Pro 
                485                 490                 495     


Ser Gly Phe Ser Gly Ser Thr Cys Gln Leu Asp Val Asp Glu Cys Ala 
            500                 505                 510         


Ser Thr Pro Cys Arg Asn Gly Ala Lys Cys Val Asp Gln Pro Asp Gly 
        515                 520                 525             


Tyr Glu Cys Arg Cys Ala Glu Gly Phe Glu Gly Thr Leu Cys Asp Arg 
    530                 535                 540                 


Asn Val Asp Asp Cys Ser Pro Asp Pro Cys His His Gly Arg Cys Val 
545                 550                 555                 560 


Asp Gly Ile Ala Ser Phe Ser Cys Ala Cys Ala Pro Gly Tyr Thr Gly 
                565                 570                 575     


Thr Arg Cys Glu Ser Gln Val Asp Glu Cys Arg Ser Gln Pro Cys Arg 
            580                 585                 590         


His Gly Gly Lys Cys Leu Asp Leu Val Asp Lys Tyr Leu Cys Arg Cys 
        595                 600                 605             


Pro Ser Gly Thr Thr Gly Val Asn Cys Glu Val Asn Ile Asp Asp Cys 
    610                 615                 620                 


Ala Ser Asn Pro Cys Thr Phe Gly Val Cys Arg Asp Gly Ile Asn Arg 
625                 630                 635                 640 


Tyr Asp Cys Val Cys Gln Pro Gly Phe Thr Gly Pro Leu Cys Asn Val 
                645                 650                 655     


Glu Ile Asn Glu Cys Ala Ser Ser Pro Cys Gly Glu Gly Gly Ser Cys 
            660                 665                 670         


Val Asp Gly Glu Asn Gly Phe Arg Cys Leu Cys Pro Pro Gly Ser Leu 
        675                 680                 685             


Pro Pro Leu Cys Leu Pro Pro Ser His Pro Cys Ala His Glu Pro Cys 
    690                 695                 700                 


Ser His Gly Ile Cys Tyr Asp Ala Pro Gly Gly Phe Arg Cys Val Cys 
705                 710                 715                 720 


Glu Pro Gly Trp Ser Gly Pro Arg Cys Ser Gln Ser Leu Ala Arg Asp 
                725                 730                 735     


Ala Cys Glu Ser Gln Pro Cys Arg Ala Gly Gly Thr Cys Ser Ser Asp 
            740                 745                 750         


Gly Met Gly Phe His Cys Thr Cys Pro Pro Gly Val Gln Gly Arg Gln 
        755                 760                 765             


Cys Glu Leu Leu Ser Pro Cys Thr Pro Asn Pro Cys Glu His Gly Gly 
    770                 775                 780                 


Arg Cys Glu Ser Ala Pro Gly Gln Leu Pro Val Cys Ser Cys Pro Gln 
785                 790                 795                 800 


Gly Trp Gln Gly Pro Arg Cys Gln Gln Asp Val Asp Glu Cys Ala Gly 
                805                 810                 815     


Pro Ala Pro Cys Gly Pro His Gly Ile Cys Thr Asn Leu Ala Gly Ser 
            820                 825                 830         


Phe Ser Cys Thr Cys His Gly Gly Tyr Thr Gly Pro Ser Cys Asp Gln 
        835                 840                 845             


Asp Ile Asn Asp Cys Asp Pro Asn Pro Cys Leu Asn Gly Gly Ser Cys 
    850                 855                 860                 


Gln Asp Gly Val Gly Ser Phe Ser Cys Ser Cys Leu Pro Gly Phe Ala 
865                 870                 875                 880 


Gly Pro Arg Cys Ala Arg Asp Val Asp Glu Cys Leu Ser Asn Pro Cys 
                885                 890                 895     


Gly Pro Gly Thr Cys Thr Asp His Val Ala Ser Phe Thr Cys Thr Cys 
            900                 905                 910         


Pro Pro Gly Tyr Gly Gly Phe His Cys Glu Gln Asp Leu Pro Asp Cys 
        915                 920                 925             


Ser Pro Ser Ser Cys Phe Asn Gly Gly Thr Cys Val Asp Gly Val Asn 
    930                 935                 940                 


Ser Phe Ser Cys Leu Cys Arg Pro Gly Tyr Thr Gly Ala His Cys Gln 
945                 950                 955                 960 


His Glu Ala Asp Pro Cys Leu Ser Arg Pro Cys Leu His Gly Gly Val 
                965                 970                 975     


Cys Ser Ala Ala His Pro Gly Phe Arg Cys Thr Cys Leu Glu Ser Phe 
            980                 985                 990         


Thr Gly Pro Gln Cys Gln Thr Leu  Val Asp Trp Cys Ser  Arg Gln Pro 
        995                 1000                 1005             


Cys Gln  Asn Gly Gly Arg Cys  Val Gln Thr Gly Ala  Tyr Cys Leu 
    1010                 1015                 1020             


Cys Pro  Pro Gly Trp Ser Gly  Arg Leu Cys Asp Ile  Arg Ser Leu 
    1025                 1030                 1035             


Pro Cys  Arg Glu Ala Ala Ala  Gln Ile Gly Val Arg  Leu Glu Gln 
    1040                 1045                 1050             


Leu Cys  Gln Ala Gly Gly Gln  Cys Val Asp Glu Asp  Ser Ser His 
    1055                 1060                 1065             


Tyr Cys  Val Cys Pro Glu Gly  Arg Thr Gly Ser His  Cys Glu Gln 
    1070                 1075                 1080             


Glu Val  Asp Pro Cys Leu Ala  Gln Pro Cys Gln His  Gly Gly Thr 
    1085                 1090                 1095             


Cys Arg  Gly Tyr Met Gly Gly  Tyr Met Cys Glu Cys  Leu Pro Gly 
    1100                 1105                 1110             


Tyr Asn  Gly Asp Asn Cys Glu  Asp Asp Val Asp Glu  Cys Ala Ser 
    1115                 1120                 1125             


Gln Pro  Cys Gln His Gly Gly  Ser Cys Ile Asp Leu  Val Ala Arg 
    1130                 1135                 1140             


Tyr Leu  Cys Ser Cys Pro Pro  Gly Thr Leu Gly Val  Leu Cys Glu 
    1145                 1150                 1155             


Ile Asn  Glu Asp Asp Cys Gly  Pro Gly Pro Pro Leu  Asp Ser Gly 
    1160                 1165                 1170             


Pro Arg  Cys Leu His Asn Gly  Thr Cys Val Asp Leu  Val Gly Gly 
    1175                 1180                 1185             


Phe Arg  Cys Thr Cys Pro Pro  Gly Tyr Thr Gly Leu  Arg Cys Glu 
    1190                 1195                 1200             


Ala Asp  Ile Asn Glu Cys Arg  Ser Gly Ala Cys His  Ala Ala His 
    1205                 1210                 1215             


Thr Arg  Asp Cys Leu Gln Asp  Pro Gly Gly Gly Phe  Arg Cys Leu 
    1220                 1225                 1230             


Cys His  Ala Gly Phe Ser Gly  Pro Arg Cys Gln Thr  Val Leu Ser 
    1235                 1240                 1245             


Pro Cys  Glu Ser Gln Pro Cys  Gln His Gly Gly Gln  Cys Arg Pro 
    1250                 1255                 1260             


Ser Pro  Gly Pro Gly Gly Gly  Leu Thr Phe Thr Cys  His Cys Ala 
    1265                 1270                 1275             


Gln Pro  Phe Trp Gly Pro Arg  Cys Glu Arg Val Ala  Arg Ser Cys 
    1280                 1285                 1290             


Arg Glu  Leu Gln Cys Pro Val  Gly Val Pro Cys Gln  Gln Thr Pro 
    1295                 1300                 1305             


Arg Gly  Pro Arg Cys Ala Cys  Pro Pro Gly Leu Ser  Gly Pro Ser 
    1310                 1315                 1320             


Cys Arg  Ser Phe Pro Gly Ser  Pro Pro Gly Ala Ser  Asn Ala Ser 
    1325                 1330                 1335             


Cys Ala  Ala Ala Pro Cys Leu  His Gly Gly Ser Cys  Arg Pro Ala 
    1340                 1345                 1350             


Pro Leu  Ala Pro Phe Phe Arg  Cys Ala Cys Ala Gln  Gly Trp Thr 
    1355                 1360                 1365             


Gly Pro  Arg Cys Glu Ala Pro  Ala Ala Ala Pro Glu  Val Ser Glu 
    1370                 1375                 1380             


Glu Pro  Arg Cys Pro Arg Ala  Ala Cys Gln Ala Lys  Arg Gly Asp 
    1385                 1390                 1395             


Gln Arg  Cys Asp Arg Glu Cys  Asn Ser Pro Gly Cys  Gly Trp Asp 
    1400                 1405                 1410             


Gly Gly  Asp Cys Ser Leu Ser  Val Gly Asp Pro Trp  Arg Gln Cys 
    1415                 1420                 1425             


Glu Ala  Leu Gln Cys Trp Arg  Leu Phe Asn Asn Ser  Arg Cys Asp 
    1430                 1435                 1440             


Pro Ala  Cys Ser Ser Pro Ala  Cys Leu Tyr Asp Asn  Phe Asp Cys 
    1445                 1450                 1455             


His Ala  Gly Gly Arg Glu Arg  Thr Cys Asn Pro Val  Tyr Glu Lys 
    1460                 1465                 1470             


Tyr Cys  Ala Asp His Phe Ala  Asp Gly Arg Cys Asp  Gln Gly Cys 
    1475                 1480                 1485             


Asn Thr  Glu Glu Cys Gly Trp  Asp Gly Leu Asp Cys  Ala Ser Glu 
    1490                 1495                 1500             


Val Pro  Ala Leu Leu Ala Arg  Gly Val Leu Val Leu  Thr Val Leu 
    1505                 1510                 1515             


Leu Pro  Pro Glu Glu Leu Leu  Arg Ser Ser Ala Asp  Phe Leu Gln 
    1520                 1525                 1530             


Arg Leu  Ser Ala Ile Leu Arg  Thr Ser Leu Arg Phe  Arg Leu Asp 
    1535                 1540                 1545             


Ala His  Gly Gln Ala Met Val  Phe Pro Tyr His Arg  Pro Ser Pro 
    1550                 1555                 1560             


Gly Ser  Glu Pro Arg Ala Arg  Arg Glu Leu Ala Pro  Glu Val Ile 
    1565                 1570                 1575             


Gly Ser  Val Val Met Leu Glu  Ile Asp Asn Arg Leu  Cys Leu Gln 
    1580                 1585                 1590             


Ser Pro  Glu Asn Asp His Cys  Phe Pro Asp Ala Gln  Ser Ala Ala 
    1595                 1600                 1605             


Asp Tyr  Leu Gly Ala Leu Ser  Ala Val Glu Arg Leu  Asp Phe Pro 
    1610                 1615                 1620             


Tyr Pro  Leu Arg Asp Val Arg  Gly Glu Pro Leu Glu  Pro Pro Glu 
    1625                 1630                 1635             


Pro Ser  Val Pro Leu Leu Pro  Leu Leu Val Ala Gly  Ala Val Leu 
    1640                 1645                 1650             


Leu Leu  Val Ile Leu Val Leu  Gly Val Met Val Ala  Arg Arg Lys 
    1655                 1660                 1665             


Arg Glu  His Ser Thr Leu Trp  Phe Pro Glu Gly Phe  Ser Leu His 
    1670                 1675                 1680             


Lys Asp  Val Ala Ser Gly His  Lys Gly Arg Arg Glu  Pro Val Gly 
    1685                 1690                 1695             


Gln Asp  Ala Leu Gly Met Lys  Asn Met Ala Lys Gly  Glu Ser Leu 
    1700                 1705                 1710             


Met Gly  Glu Val Ala Thr Asp  Trp Met Asp Thr Glu  Cys Pro Glu 
    1715                 1720                 1725             


Ala Lys  Arg Leu Lys Val Glu  Glu Pro Gly Met Gly  Ala Glu Glu 
    1730                 1735                 1740             


Ala Val  Asp Cys Arg Gln Trp  Thr Gln His His Leu  Val Ala Ala 
    1745                 1750                 1755             


Asp Ile  Arg Val Ala Pro Ala  Met Ala Leu Thr Pro  Pro Gln Gly 
    1760                 1765                 1770             


Asp Ala  Asp Ala Asp Gly Met  Asp Val Asn Val Arg  Gly Pro Asp 
    1775                 1780                 1785             


Gly Phe  Thr Pro Leu Met Leu  Ala Ser Phe Cys Gly  Gly Ala Leu 
    1790                 1795                 1800             


Glu Pro  Met Pro Thr Glu Glu  Asp Glu Ala Asp Asp  Thr Ser Ala 
    1805                 1810                 1815             


Ser Ile  Ile Ser Asp Leu Ile  Cys Gln Gly Ala Gln  Leu Gly Ala 
    1820                 1825                 1830             


Arg Thr  Asp Arg Thr Gly Glu  Thr Ala Leu His Leu  Ala Ala Arg 
    1835                 1840                 1845             


Tyr Ala  Arg Ala Asp Ala Ala  Lys Arg Leu Leu Asp  Ala Gly Ala 
    1850                 1855                 1860             


Asp Thr  Asn Ala Gln Asp His  Ser Gly Arg Thr Pro  Leu His Thr 
    1865                 1870                 1875             


Ala Val  Thr Ala Asp Ala Gln  Gly Val Phe Gln Ile  Leu Ile Arg 
    1880                 1885                 1890             


Asn Arg  Ser Thr Asp Leu Asp  Ala Arg Met Ala Asp  Gly Ser Thr 
    1895                 1900                 1905             


Ala Leu  Ile Leu Ala Ala Arg  Leu Ala Val Glu Gly  Met Val Glu 
    1910                 1915                 1920             


Glu Leu  Ile Ala Ser His Ala  Asp Val Asn Ala Val  Asp Glu Leu 
    1925                 1930                 1935             


Gly Lys  Ser Ala Leu His Trp  Ala Ala Ala Val Asn  Asn Val Glu 
    1940                 1945                 1950             


Ala Thr  Leu Ala Leu Leu Lys  Asn Gly Ala Asn Lys  Asp Met Gln 
    1955                 1960                 1965             


Asp Ser  Lys Glu Glu Thr Pro  Leu Phe Leu Ala Ala  Arg Glu Gly 
    1970                 1975                 1980             


Ser Tyr  Glu Ala Ala Lys Leu  Leu Leu Asp His Phe  Ala Asn Arg 
    1985                 1990                 1995             


Glu Ile  Thr Asp His Leu Asp  Arg Leu Pro Arg Asp  Val Ala Gln 
    2000                 2005                 2010             


Glu Arg  Leu His Gln Asp Ile  Val Arg Leu Leu Asp  Gln Pro Ser 
    2015                 2020                 2025             


Gly Pro  Arg Ser Pro Pro Gly  Pro His Gly Leu Gly  Pro Leu Leu 
    2030                 2035                 2040             


Cys Pro  Pro Gly Ala Phe Leu  Pro Gly Leu Lys Ala  Ala Gln Ser 
    2045                 2050                 2055             


Gly Ser  Lys Lys Ser Arg Arg  Pro Pro Gly Lys Ala  Gly Leu Gly 
    2060                 2065                 2070             


Pro Gln  Gly Pro Arg Gly Arg  Gly Lys Lys Leu Thr  Leu Ala Cys 
    2075                 2080                 2085             


Pro Gly  Pro Leu Ala Asp Ser  Ser Val Thr Leu Ser  Pro Val Asp 
    2090                 2095                 2100             


Ser Leu  Asp Ser Pro Arg Pro  Phe Gly Gly Pro Pro  Ala Ser Pro 
    2105                 2110                 2115             


Gly Gly  Phe Pro Leu Glu Gly  Pro Tyr Ala Ala Ala  Thr Ala Thr 
    2120                 2125                 2130             


Ala Val  Ser Leu Ala Gln Leu  Gly Gly Pro Gly Arg  Ala Gly Leu 
    2135                 2140                 2145             


Gly Arg  Gln Pro Pro Gly Gly  Cys Val Leu Ser Leu  Gly Leu Leu 
    2150                 2155                 2160             


Asn Pro  Val Ala Val Pro Leu  Asp Trp Ala Arg Leu  Pro Pro Pro 
    2165                 2170                 2175             


Ala Pro  Pro Gly Pro Ser Phe  Leu Leu Pro Leu Ala  Pro Gly Pro 
    2180                 2185                 2190             


Gln Leu  Leu Asn Pro Gly Thr  Pro Val Ser Pro Gln  Glu Arg Pro 
    2195                 2200                 2205             


Pro Pro  Tyr Leu Ala Val Pro  Gly His Gly Glu Glu  Tyr Pro Ala 
    2210                 2215                 2220             


Ala Gly  Ala His Ser Ser Pro  Pro Lys Ala Arg Phe  Leu Arg Val 
    2225                 2230                 2235             


Pro Ser  Glu His Pro Tyr Leu  Thr Pro Ser Pro Glu  Ser Pro Glu 
    2240                 2245                 2250             


His Trp  Ala Ser Pro Ser Pro  Pro Ser Leu Ser Asp  Trp Ser Glu 
    2255                 2260                 2265             


Ser Thr  Pro Ser Pro Ala Thr  Ala Thr Gly Ala Met  Ala Thr Thr 
    2270                 2275                 2280             


Thr Gly  Ala Leu Pro Ala Gln  Pro Leu Pro Leu Ser  Val Pro Ser 
    2285                 2290                 2295             


Ser Leu  Ala Gln Ala Gln Thr  Gln Leu Gly Pro Gln  Pro Glu Val 
    2300                 2305                 2310             


Thr Pro  Lys Arg Gln Val Leu  Ala 
    2315                 2320     


<210>  201
<211>  2003
<212>  PRT
<213>  Homo sapiens

<400>  201

Met Gln Pro Pro Ser Leu Leu Leu Leu Leu Leu Leu Leu Leu Leu Leu 
1               5                   10                  15      


Cys Val Ser Val Val Arg Pro Arg Gly Leu Leu Cys Gly Ser Phe Pro 
            20                  25                  30          


Glu Pro Cys Ala Asn Gly Gly Thr Cys Leu Ser Leu Ser Leu Gly Gln 
        35                  40                  45              


Gly Thr Cys Gln Cys Ala Pro Gly Phe Leu Gly Glu Thr Cys Gln Phe 
    50                  55                  60                  


Pro Asp Pro Cys Gln Asn Ala Gln Leu Cys Gln Asn Gly Gly Ser Cys 
65                  70                  75                  80  


Gln Ala Leu Leu Pro Ala Pro Leu Gly Leu Pro Ser Ser Pro Ser Pro 
                85                  90                  95      


Leu Thr Pro Ser Phe Leu Cys Thr Cys Leu Pro Gly Phe Thr Gly Glu 
            100                 105                 110         


Arg Cys Gln Ala Lys Leu Glu Asp Pro Cys Pro Pro Ser Phe Cys Ser 
        115                 120                 125             


Lys Arg Gly Arg Cys His Ile Gln Ala Ser Gly Arg Pro Gln Cys Ser 
    130                 135                 140                 


Cys Met Pro Gly Trp Thr Gly Glu Gln Cys Gln Leu Arg Asp Phe Cys 
145                 150                 155                 160 


Ser Ala Asn Pro Cys Val Asn Gly Gly Val Cys Leu Ala Thr Tyr Pro 
                165                 170                 175     


Gln Ile Gln Cys His Cys Pro Pro Gly Phe Glu Gly His Ala Cys Glu 
            180                 185                 190         


Arg Asp Val Asn Glu Cys Phe Gln Asp Pro Gly Pro Cys Pro Lys Gly 
        195                 200                 205             


Thr Ser Cys His Asn Thr Leu Gly Ser Phe Gln Cys Leu Cys Pro Val 
    210                 215                 220                 


Gly Gln Glu Gly Pro Arg Cys Glu Leu Arg Ala Gly Pro Cys Pro Pro 
225                 230                 235                 240 


Arg Gly Cys Ser Asn Gly Gly Thr Cys Gln Leu Met Pro Glu Lys Asp 
                245                 250                 255     


Ser Thr Phe His Leu Cys Leu Cys Pro Pro Gly Phe Ile Gly Pro Asp 
            260                 265                 270         


Cys Glu Val Asn Pro Asp Asn Cys Val Ser His Gln Cys Gln Asn Gly 
        275                 280                 285             


Gly Thr Cys Gln Asp Gly Leu Asp Thr Tyr Thr Cys Leu Cys Pro Glu 
    290                 295                 300                 


Thr Trp Thr Gly Trp Asp Cys Ser Glu Asp Val Asp Glu Cys Glu Thr 
305                 310                 315                 320 


Gln Gly Pro Pro His Cys Arg Asn Gly Gly Thr Cys Gln Asn Ser Ala 
                325                 330                 335     


Gly Ser Phe His Cys Val Cys Val Ser Gly Trp Gly Gly Thr Ser Cys 
            340                 345                 350         


Glu Glu Asn Leu Asp Asp Cys Ile Ala Ala Thr Cys Ala Pro Gly Ser 
        355                 360                 365             


Thr Cys Ile Asp Arg Val Gly Ser Phe Ser Cys Leu Cys Pro Pro Gly 
    370                 375                 380                 


Arg Thr Gly Leu Leu Cys His Leu Glu Asp Met Cys Leu Ser Gln Pro 
385                 390                 395                 400 


Cys His Gly Asp Ala Gln Cys Ser Thr Asn Pro Leu Thr Gly Ser Thr 
                405                 410                 415     


Leu Cys Leu Cys Gln Pro Gly Tyr Ser Gly Pro Thr Cys His Gln Asp 
            420                 425                 430         


Leu Asp Glu Cys Leu Met Ala Gln Gln Gly Pro Ser Pro Cys Glu His 
        435                 440                 445             


Gly Gly Ser Cys Leu Asn Thr Pro Gly Ser Phe Asn Cys Leu Cys Pro 
    450                 455                 460                 


Pro Gly Tyr Thr Gly Ser Arg Cys Glu Ala Asp His Asn Glu Cys Leu 
465                 470                 475                 480 


Ser Gln Pro Cys His Pro Gly Ser Thr Cys Leu Asp Leu Leu Ala Thr 
                485                 490                 495     


Phe His Cys Leu Cys Pro Pro Gly Leu Glu Gly Gln Leu Cys Glu Val 
            500                 505                 510         


Glu Thr Asn Glu Cys Ala Ser Ala Pro Cys Leu Asn His Ala Asp Cys 
        515                 520                 525             


His Asp Leu Leu Asn Gly Phe Gln Cys Ile Cys Leu Pro Gly Phe Ser 
    530                 535                 540                 


Gly Thr Arg Cys Glu Glu Asp Ile Asp Glu Cys Arg Ser Ser Pro Cys 
545                 550                 555                 560 


Ala Asn Gly Gly Gln Cys Gln Asp Gln Pro Gly Ala Phe His Cys Lys 
                565                 570                 575     


Cys Leu Pro Gly Phe Glu Gly Pro Arg Cys Gln Thr Glu Val Asp Glu 
            580                 585                 590         


Cys Leu Ser Asp Pro Cys Pro Val Gly Ala Ser Cys Leu Asp Leu Pro 
        595                 600                 605             


Gly Ala Phe Phe Cys Leu Cys Pro Ser Gly Phe Thr Gly Gln Leu Cys 
    610                 615                 620                 


Glu Val Pro Leu Cys Ala Pro Asn Leu Cys Gln Pro Lys Gln Ile Cys 
625                 630                 635                 640 


Lys Asp Gln Lys Asp Lys Ala Asn Cys Leu Cys Pro Asp Gly Ser Pro 
                645                 650                 655     


Gly Cys Ala Pro Pro Glu Asp Asn Cys Thr Cys His His Gly His Cys 
            660                 665                 670         


Gln Arg Ser Ser Cys Val Cys Asp Val Gly Trp Thr Gly Pro Glu Cys 
        675                 680                 685             


Glu Ala Glu Leu Gly Gly Cys Ile Ser Ala Pro Cys Ala His Gly Gly 
    690                 695                 700                 


Thr Cys Tyr Pro Gln Pro Ser Gly Tyr Asn Cys Thr Cys Pro Thr Gly 
705                 710                 715                 720 


Tyr Thr Gly Pro Thr Cys Ser Glu Glu Met Thr Ala Cys His Ser Gly 
                725                 730                 735     


Pro Cys Leu Asn Gly Gly Ser Cys Asn Pro Ser Pro Gly Gly Tyr Tyr 
            740                 745                 750         


Cys Thr Cys Pro Pro Ser His Thr Gly Pro Gln Cys Gln Thr Ser Thr 
        755                 760                 765             


Asp Tyr Cys Val Ser Ala Pro Cys Phe Asn Gly Gly Thr Cys Val Asn 
    770                 775                 780                 


Arg Pro Gly Thr Phe Ser Cys Leu Cys Ala Met Gly Phe Gln Gly Pro 
785                 790                 795                 800 


Arg Cys Glu Gly Lys Leu Arg Pro Ser Cys Ala Asp Ser Pro Cys Arg 
                805                 810                 815     


Asn Arg Ala Thr Cys Gln Asp Ser Pro Gln Gly Pro Arg Cys Leu Cys 
            820                 825                 830         


Pro Thr Gly Tyr Thr Gly Gly Ser Cys Gln Thr Leu Met Asp Leu Cys 
        835                 840                 845             


Ala Gln Lys Pro Cys Pro Arg Asn Ser His Cys Leu Gln Thr Gly Pro 
    850                 855                 860                 


Ser Phe His Cys Leu Cys Leu Gln Gly Trp Thr Gly Pro Leu Cys Asn 
865                 870                 875                 880 


Leu Pro Leu Ser Ser Cys Gln Lys Ala Ala Leu Ser Gln Gly Ile Asp 
                885                 890                 895     


Val Ser Ser Leu Cys His Asn Gly Gly Leu Cys Val Asp Ser Gly Pro 
            900                 905                 910         


Ser Tyr Phe Cys His Cys Pro Pro Gly Phe Gln Gly Ser Leu Cys Gln 
        915                 920                 925             


Asp His Val Asn Pro Cys Glu Ser Arg Pro Cys Gln Asn Gly Ala Thr 
    930                 935                 940                 


Cys Met Ala Gln Pro Ser Gly Tyr Leu Cys Gln Cys Ala Pro Gly Tyr 
945                 950                 955                 960 


Asp Gly Gln Asn Cys Ser Lys Glu Leu Asp Ala Cys Gln Ser Gln Pro 
                965                 970                 975     


Cys His Asn His Gly Thr Cys Thr Pro Lys Pro Gly Gly Phe His Cys 
            980                 985                 990         


Ala Cys Pro Pro Gly Phe Val Gly  Leu Arg Cys Glu Gly  Asp Val Asp 
        995                 1000                 1005             


Glu Cys  Leu Asp Gln Pro Cys  His Pro Thr Gly Thr  Ala Ala Cys 
    1010                 1015                 1020             


His Ser  Leu Ala Asn Ala Phe  Tyr Cys Gln Cys Leu  Pro Gly His 
    1025                 1030                 1035             


Thr Gly  Gln Trp Cys Glu Val  Glu Ile Asp Pro Cys  His Ser Gln 
    1040                 1045                 1050             


Pro Cys  Phe His Gly Gly Thr  Cys Glu Ala Thr Ala  Gly Ser Pro 
    1055                 1060                 1065             


Leu Gly  Phe Ile Cys His Cys  Pro Lys Gly Phe Glu  Gly Pro Thr 
    1070                 1075                 1080             


Cys Ser  His Arg Ala Pro Ser  Cys Gly Phe His His  Cys His His 
    1085                 1090                 1095             


Gly Gly  Leu Cys Leu Pro Ser  Pro Lys Pro Gly Phe  Pro Pro Arg 
    1100                 1105                 1110             


Cys Ala  Cys Leu Ser Gly Tyr  Gly Gly Pro Asp Cys  Leu Thr Pro 
    1115                 1120                 1125             


Pro Ala  Pro Lys Gly Cys Gly  Pro Pro Ser Pro Cys  Leu Tyr Asn 
    1130                 1135                 1140             


Gly Ser  Cys Ser Glu Thr Thr  Gly Leu Gly Gly Pro  Gly Phe Arg 
    1145                 1150                 1155             


Cys Ser  Cys Pro His Ser Ser  Pro Gly Pro Arg Cys  Gln Lys Pro 
    1160                 1165                 1170             


Gly Ala  Lys Gly Cys Glu Gly  Arg Ser Gly Asp Gly  Ala Cys Asp 
    1175                 1180                 1185             


Ala Gly  Cys Ser Gly Pro Gly  Gly Asn Trp Asp Gly  Gly Asp Cys 
    1190                 1195                 1200             


Ser Leu  Gly Val Pro Asp Pro  Trp Lys Gly Cys Pro  Ser His Ser 
    1205                 1210                 1215             


Arg Cys  Trp Leu Leu Phe Arg  Asp Gly Gln Cys His  Pro Gln Cys 
    1220                 1225                 1230             


Asp Ser  Glu Glu Cys Leu Phe  Asp Gly Tyr Asp Cys  Glu Thr Pro 
    1235                 1240                 1245             


Pro Ala  Cys Thr Pro Ala Tyr  Asp Gln Tyr Cys His  Asp His Phe 
    1250                 1255                 1260             


His Asn  Gly His Cys Glu Lys  Gly Cys Asn Thr Ala  Glu Cys Gly 
    1265                 1270                 1275             


Trp Asp  Gly Gly Asp Cys Arg  Pro Glu Asp Gly Asp  Pro Glu Trp 
    1280                 1285                 1290             


Gly Pro  Ser Leu Ala Leu Leu  Val Val Leu Ser Pro  Pro Ala Leu 
    1295                 1300                 1305             


Asp Gln  Gln Leu Phe Ala Leu  Ala Arg Val Leu Ser  Leu Thr Leu 
    1310                 1315                 1320             


Arg Val  Gly Leu Trp Val Arg  Lys Asp Arg Asp Gly  Arg Asp Met 
    1325                 1330                 1335             


Val Tyr  Pro Tyr Pro Gly Ala  Arg Ala Glu Glu Lys  Leu Gly Gly 
    1340                 1345                 1350             


Thr Arg  Asp Pro Thr Tyr Gln  Glu Arg Ala Ala Pro  Gln Thr Gln 
    1355                 1360                 1365             


Pro Leu  Gly Lys Glu Thr Asp  Ser Leu Ser Ala Gly  Phe Val Val 
    1370                 1375                 1380             


Val Met  Gly Val Asp Leu Ser  Arg Cys Gly Pro Asp  His Pro Ala 
    1385                 1390                 1395             


Ser Arg  Cys Pro Trp Asp Pro  Gly Leu Leu Leu Arg  Phe Leu Ala 
    1400                 1405                 1410             


Ala Met  Ala Ala Val Gly Ala  Leu Glu Pro Leu Leu  Pro Gly Pro 
    1415                 1420                 1425             


Leu Leu  Ala Val His Pro His  Ala Gly Thr Ala Pro  Pro Ala Asn 
    1430                 1435                 1440             


Gln Leu  Pro Trp Pro Val Leu  Cys Ser Pro Val Ala  Gly Val Ile 
    1445                 1450                 1455             


Leu Leu  Ala Leu Gly Ala Leu  Leu Val Leu Gln Leu  Ile Arg Arg 
    1460                 1465                 1470             


Arg Arg  Arg Glu His Gly Ala  Leu Trp Leu Pro Pro  Gly Phe Thr 
    1475                 1480                 1485             


Arg Arg  Pro Arg Thr Gln Ser  Ala Pro His Arg Arg  Arg Pro Pro 
    1490                 1495                 1500             


Leu Gly  Glu Asp Ser Ile Gly  Leu Lys Ala Leu Lys  Pro Lys Ala 
    1505                 1510                 1515             


Glu Val  Asp Glu Asp Gly Val  Val Met Cys Ser Gly  Pro Glu Glu 
    1520                 1525                 1530             


Gly Glu  Glu Val Gly Gln Ala  Glu Glu Thr Gly Pro  Pro Ser Thr 
    1535                 1540                 1545             


Cys Gln  Leu Trp Ser Leu Ser  Gly Gly Cys Gly Ala  Leu Pro Gln 
    1550                 1555                 1560             


Ala Ala  Met Leu Thr Pro Pro  Gln Glu Ser Glu Met  Glu Ala Pro 
    1565                 1570                 1575             


Asp Leu  Asp Thr Arg Gly Pro  Asp Gly Val Thr Pro  Leu Met Ser 
    1580                 1585                 1590             


Ala Val  Cys Cys Gly Glu Val  Gln Ser Gly Thr Phe  Gln Gly Ala 
    1595                 1600                 1605             


Trp Leu  Gly Cys Pro Glu Pro  Trp Glu Pro Leu Leu  Asp Gly Gly 
    1610                 1615                 1620             


Ala Cys  Pro Gln Ala His Thr  Val Gly Thr Gly Glu  Thr Pro Leu 
    1625                 1630                 1635             


His Leu  Ala Ala Arg Phe Ser  Arg Pro Thr Ala Ala  Arg Arg Leu 
    1640                 1645                 1650             


Leu Glu  Ala Gly Ala Asn Pro  Asn Gln Pro Asp Arg  Ala Gly Arg 
    1655                 1660                 1665             


Thr Pro  Leu His Ala Ala Val  Ala Ala Asp Ala Arg  Glu Val Cys 
    1670                 1675                 1680             


Gln Leu  Leu Leu Arg Ser Arg  Gln Thr Ala Val Asp  Ala Arg Thr 
    1685                 1690                 1695             


Glu Asp  Gly Thr Thr Pro Leu  Met Leu Ala Ala Arg  Leu Ala Val 
    1700                 1705                 1710             


Glu Asp  Leu Val Glu Glu Leu  Ile Ala Ala Gln Ala  Asp Val Gly 
    1715                 1720                 1725             


Ala Arg  Asp Lys Trp Gly Lys  Thr Ala Leu His Trp  Ala Ala Ala 
    1730                 1735                 1740             


Val Asn  Asn Ala Arg Ala Ala  Arg Ser Leu Leu Gln  Ala Gly Ala 
    1745                 1750                 1755             


Asp Lys  Asp Ala Gln Asp Asn  Arg Glu Gln Thr Pro  Leu Phe Leu 
    1760                 1765                 1770             


Ala Ala  Arg Glu Gly Ala Val  Glu Val Ala Gln Leu  Leu Leu Gly 
    1775                 1780                 1785             


Leu Gly  Ala Ala Arg Glu Leu  Arg Asp Gln Ala Gly  Leu Ala Pro 
    1790                 1795                 1800             


Ala Asp  Val Ala His Gln Arg  Asn His Trp Asp Leu  Leu Thr Leu 
    1805                 1810                 1815             


Leu Glu  Gly Ala Gly Pro Pro  Glu Ala Arg His Lys  Ala Thr Pro 
    1820                 1825                 1830             


Gly Arg  Glu Ala Gly Pro Phe  Pro Arg Ala Arg Thr  Val Ser Val 
    1835                 1840                 1845             


Ser Val  Pro Pro His Gly Gly  Gly Ala Leu Pro Arg  Cys Arg Thr 
    1850                 1855                 1860             


Leu Ser  Ala Gly Ala Gly Pro  Arg Gly Gly Gly Ala  Cys Leu Gln 
    1865                 1870                 1875             


Ala Arg  Thr Trp Ser Val Asp  Leu Ala Ala Arg Gly  Gly Gly Ala 
    1880                 1885                 1890             


Tyr Ser  His Cys Arg Ser Leu  Ser Gly Val Gly Ala  Gly Gly Gly 
    1895                 1900                 1905             


Pro Thr  Pro Arg Gly Arg Arg  Phe Ser Ala Gly Met  Arg Gly Pro 
    1910                 1915                 1920             


Arg Pro  Asn Pro Ala Ile Met  Arg Gly Arg Tyr Gly  Val Ala Ala 
    1925                 1930                 1935             


Gly Arg  Gly Gly Arg Val Ser  Thr Asp Asp Trp Pro  Cys Asp Trp 
    1940                 1945                 1950             


Val Ala  Leu Gly Ala Cys Gly  Ser Ala Ser Asn Ile  Pro Ile Pro 
    1955                 1960                 1965             


Pro Pro  Cys Leu Thr Pro Ser  Pro Glu Arg Gly Ser  Pro Gln Leu 
    1970                 1975                 1980             


Asp Cys  Gly Pro Pro Ala Leu  Gln Glu Met Pro Ile  Asn Gln Gly 
    1985                 1990                 1995             


Gly Glu  Gly Lys Lys 
    2000             


<210>  202
<211>  723
<212>  PRT
<213>  Homo sapiens

<400>  202

Met Gly Ser Arg Cys Ala Leu Ala Leu Ala Val Leu Ser Ala Leu Leu 
1               5                   10                  15      


Cys Gln Val Trp Ser Ser Gly Val Phe Glu Leu Lys Leu Gln Glu Phe 
            20                  25                  30          


Val Asn Lys Lys Gly Leu Leu Gly Asn Arg Asn Cys Cys Arg Gly Gly 
        35                  40                  45              


Ala Gly Pro Pro Pro Cys Ala Cys Arg Thr Phe Phe Arg Val Cys Leu 
    50                  55                  60                  


Lys His Tyr Gln Ala Ser Val Ser Pro Glu Pro Pro Cys Thr Tyr Gly 
65                  70                  75                  80  


Ser Ala Val Thr Pro Val Leu Gly Val Asp Ser Phe Ser Leu Pro Asp 
                85                  90                  95      


Gly Gly Gly Ala Asp Ser Ala Phe Ser Asn Pro Ile Arg Phe Pro Phe 
            100                 105                 110         


Gly Phe Thr Trp Pro Gly Thr Phe Ser Leu Ile Ile Glu Ala Leu His 
        115                 120                 125             


Thr Asp Ser Pro Asp Asp Leu Ala Thr Glu Asn Pro Glu Arg Leu Ile 
    130                 135                 140                 


Ser Arg Leu Ala Thr Gln Arg His Leu Thr Val Gly Glu Glu Trp Ser 
145                 150                 155                 160 


Gln Asp Leu His Ser Ser Gly Arg Thr Asp Leu Lys Tyr Ser Tyr Arg 
                165                 170                 175     


Phe Val Cys Asp Glu His Tyr Tyr Gly Glu Gly Cys Ser Val Phe Cys 
            180                 185                 190         


Arg Pro Arg Asp Asp Ala Phe Gly His Phe Thr Cys Gly Glu Arg Gly 
        195                 200                 205             


Glu Lys Val Cys Asn Pro Gly Trp Lys Gly Pro Tyr Cys Thr Glu Pro 
    210                 215                 220                 


Ile Cys Leu Pro Gly Cys Asp Glu Gln His Gly Phe Cys Asp Lys Pro 
225                 230                 235                 240 


Gly Glu Cys Lys Cys Arg Val Gly Trp Gln Gly Arg Tyr Cys Asp Glu 
                245                 250                 255     


Cys Ile Arg Tyr Pro Gly Cys Leu His Gly Thr Cys Gln Gln Pro Trp 
            260                 265                 270         


Gln Cys Asn Cys Gln Glu Gly Trp Gly Gly Leu Phe Cys Asn Gln Asp 
        275                 280                 285             


Leu Asn Tyr Cys Thr His His Lys Pro Cys Lys Asn Gly Ala Thr Cys 
    290                 295                 300                 


Thr Asn Thr Gly Gln Gly Ser Tyr Thr Cys Ser Cys Arg Pro Gly Tyr 
305                 310                 315                 320 


Thr Gly Ala Thr Cys Glu Leu Gly Ile Asp Glu Cys Asp Pro Ser Pro 
                325                 330                 335     


Cys Lys Asn Gly Gly Ser Cys Thr Asp Leu Glu Asn Ser Tyr Ser Cys 
            340                 345                 350         


Thr Cys Pro Pro Gly Phe Tyr Gly Lys Ile Cys Glu Leu Ser Ala Met 
        355                 360                 365             


Thr Cys Ala Asp Gly Pro Cys Phe Asn Gly Gly Arg Cys Ser Asp Ser 
    370                 375                 380                 


Pro Asp Gly Gly Tyr Ser Cys Arg Cys Pro Val Gly Tyr Ser Gly Phe 
385                 390                 395                 400 


Asn Cys Glu Lys Lys Ile Asp Tyr Cys Ser Ser Ser Pro Cys Ser Asn 
                405                 410                 415     


Gly Ala Lys Cys Val Asp Leu Gly Asp Ala Tyr Leu Cys Arg Cys Gln 
            420                 425                 430         


Ala Gly Phe Ser Gly Arg His Cys Asp Asp Asn Val Asp Asp Cys Ala 
        435                 440                 445             


Ser Ser Pro Cys Ala Asn Gly Gly Thr Cys Arg Asp Gly Val Asn Asp 
    450                 455                 460                 


Phe Ser Cys Thr Cys Pro Pro Gly Tyr Thr Gly Arg Asn Cys Ser Ala 
465                 470                 475                 480 


Pro Val Ser Arg Cys Glu His Ala Pro Cys His Asn Gly Ala Thr Cys 
                485                 490                 495     


His Glu Arg Gly His Arg Tyr Val Cys Glu Cys Ala Arg Gly Tyr Gly 
            500                 505                 510         


Gly Pro Asn Cys Gln Phe Leu Leu Pro Glu Leu Pro Pro Gly Pro Ala 
        515                 520                 525             


Val Val Asp Leu Thr Glu Lys Leu Glu Gly Gln Gly Gly Pro Phe Pro 
    530                 535                 540                 


Trp Val Ala Val Cys Ala Gly Val Ile Leu Val Leu Met Leu Leu Leu 
545                 550                 555                 560 


Gly Cys Ala Ala Val Val Val Cys Val Arg Leu Arg Leu Gln Lys His 
                565                 570                 575     


Arg Pro Pro Ala Asp Pro Cys Arg Gly Glu Thr Glu Thr Met Asn Asn 
            580                 585                 590         


Leu Ala Asn Cys Gln Arg Glu Lys Asp Ile Ser Val Ser Ile Ile Gly 
        595                 600                 605             


Ala Thr Gln Ile Lys Asn Thr Asn Lys Lys Ala Asp Phe His Gly Asp 
    610                 615                 620                 


His Ser Ala Asp Lys Asn Gly Phe Lys Ala Arg Tyr Pro Ala Val Asp 
625                 630                 635                 640 


Tyr Asn Leu Val Gln Asp Leu Lys Gly Asp Asp Thr Ala Val Arg Asp 
                645                 650                 655     


Ala His Ser Lys Arg Asp Thr Lys Cys Gln Pro Gln Gly Ser Ser Gly 
            660                 665                 670         


Glu Glu Lys Gly Thr Pro Thr Thr Leu Arg Gly Gly Glu Ala Ser Glu 
        675                 680                 685             


Arg Lys Arg Pro Asp Ser Gly Cys Ser Thr Ser Lys Asp Thr Lys Tyr 
    690                 695                 700                 


Gln Ser Val Tyr Val Ile Ser Glu Glu Lys Asp Glu Cys Val Ile Ala 
705                 710                 715                 720 


Thr Glu Val 
            


<210>  203
<211>  685
<212>  PRT
<213>  Homo sapiens

<400>  203

Met Ala Ala Ala Ser Arg Ser Ala Ser Gly Trp Ala Leu Leu Leu Leu 
1               5                   10                  15      


Val Ala Leu Trp Gln Gln Arg Ala Ala Gly Ser Gly Val Phe Gln Leu 
            20                  25                  30          


Gln Leu Gln Glu Phe Ile Asn Glu Arg Gly Val Leu Ala Ser Gly Arg 
        35                  40                  45              


Pro Cys Glu Pro Gly Cys Arg Thr Phe Phe Arg Val Cys Leu Lys His 
    50                  55                  60                  


Phe Gln Ala Val Val Ser Pro Gly Pro Cys Thr Phe Gly Thr Val Ser 
65                  70                  75                  80  


Thr Pro Val Leu Gly Thr Asn Ser Phe Ala Val Arg Asp Asp Ser Ser 
                85                  90                  95      


Gly Gly Gly Arg Asn Pro Leu Gln Leu Pro Phe Asn Phe Thr Trp Pro 
            100                 105                 110         


Gly Thr Phe Ser Leu Ile Ile Glu Ala Trp His Ala Pro Gly Asp Asp 
        115                 120                 125             


Leu Arg Pro Glu Ala Leu Pro Pro Asp Ala Leu Ile Ser Lys Ile Ala 
    130                 135                 140                 


Ile Gln Gly Ser Leu Ala Val Gly Gln Asn Trp Leu Leu Asp Glu Gln 
145                 150                 155                 160 


Thr Ser Thr Leu Thr Arg Leu Arg Tyr Ser Tyr Arg Val Ile Cys Ser 
                165                 170                 175     


Asp Asn Tyr Tyr Gly Asp Asn Cys Ser Arg Leu Cys Lys Lys Arg Asn 
            180                 185                 190         


Asp His Phe Gly His Tyr Val Cys Gln Pro Asp Gly Asn Leu Ser Cys 
        195                 200                 205             


Leu Pro Gly Trp Thr Gly Glu Tyr Cys Gln Gln Pro Ile Cys Leu Ser 
    210                 215                 220                 


Gly Cys His Glu Gln Asn Gly Tyr Cys Ser Lys Pro Ala Glu Cys Leu 
225                 230                 235                 240 


Cys Arg Pro Gly Trp Gln Gly Arg Leu Cys Asn Glu Cys Ile Pro His 
                245                 250                 255     


Asn Gly Cys Arg His Gly Thr Cys Ser Thr Pro Trp Gln Cys Thr Cys 
            260                 265                 270         


Asp Glu Gly Trp Gly Gly Leu Phe Cys Asp Gln Asp Leu Asn Tyr Cys 
        275                 280                 285             


Thr His His Ser Pro Cys Lys Asn Gly Ala Thr Cys Ser Asn Ser Gly 
    290                 295                 300                 


Gln Arg Ser Tyr Thr Cys Thr Cys Arg Pro Gly Tyr Thr Gly Val Asp 
305                 310                 315                 320 


Cys Glu Leu Glu Leu Ser Glu Cys Asp Ser Asn Pro Cys Arg Asn Gly 
                325                 330                 335     


Gly Ser Cys Lys Asp Gln Glu Asp Gly Tyr His Cys Leu Cys Pro Pro 
            340                 345                 350         


Gly Tyr Tyr Gly Leu His Cys Glu His Ser Thr Leu Ser Cys Ala Asp 
        355                 360                 365             


Ser Pro Cys Phe Asn Gly Gly Ser Cys Arg Glu Arg Asn Gln Gly Ala 
    370                 375                 380                 


Asn Tyr Ala Cys Glu Cys Pro Pro Asn Phe Thr Gly Ser Asn Cys Glu 
385                 390                 395                 400 


Lys Lys Val Asp Arg Cys Thr Ser Asn Pro Cys Ala Asn Gly Gly Gln 
                405                 410                 415     


Cys Leu Asn Arg Gly Pro Ser Arg Met Cys Arg Cys Arg Pro Gly Phe 
            420                 425                 430         


Thr Gly Thr Tyr Cys Glu Leu His Val Ser Asp Cys Ala Arg Asn Pro 
        435                 440                 445             


Cys Ala His Gly Gly Thr Cys His Asp Leu Glu Asn Gly Leu Met Cys 
    450                 455                 460                 


Thr Cys Pro Ala Gly Phe Ser Gly Arg Arg Cys Glu Val Arg Thr Ser 
465                 470                 475                 480 


Ile Asp Ala Cys Ala Ser Ser Pro Cys Phe Asn Arg Ala Thr Cys Tyr 
                485                 490                 495     


Thr Asp Leu Ser Thr Asp Thr Phe Val Cys Asn Cys Pro Tyr Gly Phe 
            500                 505                 510         


Val Gly Ser Arg Cys Glu Phe Pro Val Gly Leu Pro Pro Ser Phe Pro 
        515                 520                 525             


Trp Val Ala Val Ser Leu Gly Val Gly Leu Ala Val Leu Leu Val Leu 
    530                 535                 540                 


Leu Gly Met Val Ala Val Ala Val Arg Gln Leu Arg Leu Arg Arg Pro 
545                 550                 555                 560 


Asp Asp Gly Ser Arg Glu Ala Met Asn Asn Leu Ser Asp Phe Gln Lys 
                565                 570                 575     


Asp Asn Leu Ile Pro Ala Ala Gln Leu Lys Asn Thr Asn Gln Lys Lys 
            580                 585                 590         


Glu Leu Glu Val Asp Cys Gly Leu Asp Lys Ser Asn Cys Gly Lys Gln 
        595                 600                 605             


Gln Asn His Thr Leu Asp Tyr Asn Leu Ala Pro Gly Pro Leu Gly Arg 
    610                 615                 620                 


Gly Thr Met Pro Gly Lys Phe Pro His Ser Asp Lys Ser Leu Gly Glu 
625                 630                 635                 640 


Lys Ala Pro Leu Arg Leu His Ser Glu Lys Pro Glu Cys Arg Ile Ser 
                645                 650                 655     


Ala Ile Cys Ser Pro Arg Asp Ser Met Tyr Gln Ser Val Cys Leu Ile 
            660                 665                 670         


Ser Glu Glu Arg Asn Glu Cys Val Ile Ala Thr Glu Val 
        675                 680                 685 


<210>  204
<211>  1218
<212>  PRT
<213>  Homo sapiens

<400>  204

Met Arg Ser Pro Arg Thr Arg Gly Arg Ser Gly Arg Pro Leu Ser Leu 
1               5                   10                  15      


Leu Leu Ala Leu Leu Cys Ala Leu Arg Ala Lys Val Cys Gly Ala Ser 
            20                  25                  30          


Gly Gln Phe Glu Leu Glu Ile Leu Ser Met Gln Asn Val Asn Gly Glu 
        35                  40                  45              


Leu Gln Asn Gly Asn Cys Cys Gly Gly Ala Arg Asn Pro Gly Asp Arg 
    50                  55                  60                  


Lys Cys Thr Arg Asp Glu Cys Asp Thr Tyr Phe Lys Val Cys Leu Lys 
65                  70                  75                  80  


Glu Tyr Gln Ser Arg Val Thr Ala Gly Gly Pro Cys Ser Phe Gly Ser 
                85                  90                  95      


Gly Ser Thr Pro Val Ile Gly Gly Asn Thr Phe Asn Leu Lys Ala Ser 
            100                 105                 110         


Arg Gly Asn Asp Arg Asn Arg Ile Val Leu Pro Phe Ser Phe Ala Trp 
        115                 120                 125             


Pro Arg Ser Tyr Thr Leu Leu Val Glu Ala Trp Asp Ser Ser Asn Asp 
    130                 135                 140                 


Thr Val Gln Pro Asp Ser Ile Ile Glu Lys Ala Ser His Ser Gly Met 
145                 150                 155                 160 


Ile Asn Pro Ser Arg Gln Trp Gln Thr Leu Lys Gln Asn Thr Gly Val 
                165                 170                 175     


Ala His Phe Glu Tyr Gln Ile Arg Val Thr Cys Asp Asp Tyr Tyr Tyr 
            180                 185                 190         


Gly Phe Gly Cys Asn Lys Phe Cys Arg Pro Arg Asp Asp Phe Phe Gly 
        195                 200                 205             


His Tyr Ala Cys Asp Gln Asn Gly Asn Lys Thr Cys Met Glu Gly Trp 
    210                 215                 220                 


Met Gly Pro Glu Cys Asn Arg Ala Ile Cys Arg Gln Gly Cys Ser Pro 
225                 230                 235                 240 


Lys His Gly Ser Cys Lys Leu Pro Gly Asp Cys Arg Cys Gln Tyr Gly 
                245                 250                 255     


Trp Gln Gly Leu Tyr Cys Asp Lys Cys Ile Pro His Pro Gly Cys Val 
            260                 265                 270         


His Gly Ile Cys Asn Glu Pro Trp Gln Cys Leu Cys Glu Thr Asn Trp 
        275                 280                 285             


Gly Gly Gln Leu Cys Asp Lys Asp Leu Asn Tyr Cys Gly Thr His Gln 
    290                 295                 300                 


Pro Cys Leu Asn Gly Gly Thr Cys Ser Asn Thr Gly Pro Asp Lys Tyr 
305                 310                 315                 320 


Gln Cys Ser Cys Pro Glu Gly Tyr Ser Gly Pro Asn Cys Glu Ile Ala 
                325                 330                 335     


Glu His Ala Cys Leu Ser Asp Pro Cys His Asn Arg Gly Ser Cys Lys 
            340                 345                 350         


Glu Thr Ser Leu Gly Phe Glu Cys Glu Cys Ser Pro Gly Trp Thr Gly 
        355                 360                 365             


Pro Thr Cys Ser Thr Asn Ile Asp Asp Cys Ser Pro Asn Asn Cys Ser 
    370                 375                 380                 


His Gly Gly Thr Cys Gln Asp Leu Val Asn Gly Phe Lys Cys Val Cys 
385                 390                 395                 400 


Pro Pro Gln Trp Thr Gly Lys Thr Cys Gln Leu Asp Ala Asn Glu Cys 
                405                 410                 415     


Glu Ala Lys Pro Cys Val Asn Ala Lys Ser Cys Lys Asn Leu Ile Ala 
            420                 425                 430         


Ser Tyr Tyr Cys Asp Cys Leu Pro Gly Trp Met Gly Gln Asn Cys Asp 
        435                 440                 445             


Ile Asn Ile Asn Asp Cys Leu Gly Gln Cys Gln Asn Asp Ala Ser Cys 
    450                 455                 460                 


Arg Asp Leu Val Asn Gly Tyr Arg Cys Ile Cys Pro Pro Gly Tyr Ala 
465                 470                 475                 480 


Gly Asp His Cys Glu Arg Asp Ile Asp Glu Cys Ala Ser Asn Pro Cys 
                485                 490                 495     


Leu Asn Gly Gly His Cys Gln Asn Glu Ile Asn Arg Phe Gln Cys Leu 
            500                 505                 510         


Cys Pro Thr Gly Phe Ser Gly Asn Leu Cys Gln Leu Asp Ile Asp Tyr 
        515                 520                 525             


Cys Glu Pro Asn Pro Cys Gln Asn Gly Ala Gln Cys Tyr Asn Arg Ala 
    530                 535                 540                 


Ser Asp Tyr Phe Cys Lys Cys Pro Glu Asp Tyr Glu Gly Lys Asn Cys 
545                 550                 555                 560 


Ser His Leu Lys Asp His Cys Arg Thr Thr Pro Cys Glu Val Ile Asp 
                565                 570                 575     


Ser Cys Thr Val Ala Met Ala Ser Asn Asp Thr Pro Glu Gly Val Arg 
            580                 585                 590         


Tyr Ile Ser Ser Asn Val Cys Gly Pro His Gly Lys Cys Lys Ser Gln 
        595                 600                 605             


Ser Gly Gly Lys Phe Thr Cys Asp Cys Asn Lys Gly Phe Thr Gly Thr 
    610                 615                 620                 


Tyr Cys His Glu Asn Ile Asn Asp Cys Glu Ser Asn Pro Cys Arg Asn 
625                 630                 635                 640 


Gly Gly Thr Cys Ile Asp Gly Val Asn Ser Tyr Lys Cys Ile Cys Ser 
                645                 650                 655     


Asp Gly Trp Glu Gly Ala Tyr Cys Glu Thr Asn Ile Asn Asp Cys Ser 
            660                 665                 670         


Gln Asn Pro Cys His Asn Gly Gly Thr Cys Arg Asp Leu Val Asn Asp 
        675                 680                 685             


Phe Tyr Cys Asp Cys Lys Asn Gly Trp Lys Gly Lys Thr Cys His Ser 
    690                 695                 700                 


Arg Asp Ser Gln Cys Asp Glu Ala Thr Cys Asn Asn Gly Gly Thr Cys 
705                 710                 715                 720 


Tyr Asp Glu Gly Asp Ala Phe Lys Cys Met Cys Pro Gly Gly Trp Glu 
                725                 730                 735     


Gly Thr Thr Cys Asn Ile Ala Arg Asn Ser Ser Cys Leu Pro Asn Pro 
            740                 745                 750         


Cys His Asn Gly Gly Thr Cys Val Val Asn Gly Glu Ser Phe Thr Cys 
        755                 760                 765             


Val Cys Lys Glu Gly Trp Glu Gly Pro Ile Cys Ala Gln Asn Thr Asn 
    770                 775                 780                 


Asp Cys Ser Pro His Pro Cys Tyr Asn Ser Gly Thr Cys Val Asp Gly 
785                 790                 795                 800 


Asp Asn Trp Tyr Arg Cys Glu Cys Ala Pro Gly Phe Ala Gly Pro Asp 
                805                 810                 815     


Cys Arg Ile Asn Ile Asn Glu Cys Gln Ser Ser Pro Cys Ala Phe Gly 
            820                 825                 830         


Ala Thr Cys Val Asp Glu Ile Asn Gly Tyr Arg Cys Val Cys Pro Pro 
        835                 840                 845             


Gly His Ser Gly Ala Lys Cys Gln Glu Val Ser Gly Arg Pro Cys Ile 
    850                 855                 860                 


Thr Met Gly Ser Val Ile Pro Asp Gly Ala Lys Trp Asp Asp Asp Cys 
865                 870                 875                 880 


Asn Thr Cys Gln Cys Leu Asn Gly Arg Ile Ala Cys Ser Lys Val Trp 
                885                 890                 895     


Cys Gly Pro Arg Pro Cys Leu Leu His Lys Gly His Ser Glu Cys Pro 
            900                 905                 910         


Ser Gly Gln Ser Cys Ile Pro Ile Leu Asp Asp Gln Cys Phe Val His 
        915                 920                 925             


Pro Cys Thr Gly Val Gly Glu Cys Arg Ser Ser Ser Leu Gln Pro Val 
    930                 935                 940                 


Lys Thr Lys Cys Thr Ser Asp Ser Tyr Tyr Gln Asp Asn Cys Ala Asn 
945                 950                 955                 960 


Ile Thr Phe Thr Phe Asn Lys Glu Met Met Ser Pro Gly Leu Thr Thr 
                965                 970                 975     


Glu His Ile Cys Ser Glu Leu Arg Asn Leu Asn Ile Leu Lys Asn Val 
            980                 985                 990         


Ser Ala Glu Tyr Ser Ile Tyr Ile  Ala Cys Glu Pro Ser  Pro Ser Ala 
        995                 1000                 1005             


Asn Asn  Glu Ile His Val Ala  Ile Ser Ala Glu Asp  Ile Arg Asp 
    1010                 1015                 1020             


Asp Gly  Asn Pro Ile Lys Glu  Ile Thr Asp Lys Ile  Ile Asp Leu 
    1025                 1030                 1035             


Val Ser  Lys Arg Asp Gly Asn  Ser Ser Leu Ile Ala  Ala Val Ala 
    1040                 1045                 1050             


Glu Val  Arg Val Gln Arg Arg  Pro Leu Lys Asn Arg  Thr Asp Phe 
    1055                 1060                 1065             


Leu Val  Pro Leu Leu Ser Ser  Val Leu Thr Val Ala  Trp Ile Cys 
    1070                 1075                 1080             


Cys Leu  Val Thr Ala Phe Tyr  Trp Cys Leu Arg Lys  Arg Arg Lys 
    1085                 1090                 1095             


Pro Gly  Ser His Thr His Ser  Ala Ser Glu Asp Asn  Thr Thr Asn 
    1100                 1105                 1110             


Asn Val  Arg Glu Gln Leu Asn  Gln Ile Lys Asn Pro  Ile Glu Lys 
    1115                 1120                 1125             


His Gly  Ala Asn Thr Val Pro  Ile Lys Asp Tyr Glu  Asn Lys Asn 
    1130                 1135                 1140             


Ser Lys  Met Ser Lys Ile Arg  Thr His Asn Ser Glu  Val Glu Glu 
    1145                 1150                 1155             


Asp Asp  Met Asp Lys His Gln  Gln Lys Ala Arg Phe  Ala Lys Gln 
    1160                 1165                 1170             


Pro Ala  Tyr Thr Leu Val Asp  Arg Glu Glu Lys Pro  Pro Asn Gly 
    1175                 1180                 1185             


Thr Pro  Thr Lys His Pro Asn  Trp Thr Asn Lys Gln  Asp Asn Arg 
    1190                 1195                 1200             


Asp Leu  Glu Ser Ala Gln Ser  Leu Asn Arg Met Glu  Tyr Ile Val 
    1205                 1210                 1215             


<210>  205
<211>  1238
<212>  PRT
<213>  Homo sapiens

<400>  205

Met Arg Ala Gln Gly Arg Gly Arg Leu Pro Arg Arg Leu Leu Leu Leu 
1               5                   10                  15      


Leu Ala Leu Trp Val Gln Ala Ala Arg Pro Met Gly Tyr Phe Glu Leu 
            20                  25                  30          


Gln Leu Ser Ala Leu Arg Asn Val Asn Gly Glu Leu Leu Ser Gly Ala 
        35                  40                  45              


Cys Cys Asp Gly Asp Gly Arg Thr Thr Arg Ala Gly Gly Cys Gly His 
    50                  55                  60                  


Asp Glu Cys Asp Thr Tyr Val Arg Val Cys Leu Lys Glu Tyr Gln Ala 
65                  70                  75                  80  


Lys Val Thr Pro Thr Gly Pro Cys Ser Tyr Gly His Gly Ala Thr Pro 
                85                  90                  95      


Val Leu Gly Gly Asn Ser Phe Tyr Leu Pro Pro Ala Gly Ala Ala Gly 
            100                 105                 110         


Asp Arg Ala Arg Ala Arg Ala Arg Ala Gly Gly Asp Gln Asp Pro Gly 
        115                 120                 125             


Leu Val Val Ile Pro Phe Gln Phe Ala Trp Pro Arg Ser Phe Thr Leu 
    130                 135                 140                 


Ile Val Glu Ala Trp Asp Trp Asp Asn Asp Thr Thr Pro Asn Glu Glu 
145                 150                 155                 160 


Leu Leu Ile Glu Arg Val Ser His Ala Gly Met Ile Asn Pro Glu Asp 
                165                 170                 175     


Arg Trp Lys Ser Leu His Phe Ser Gly His Val Ala His Leu Glu Leu 
            180                 185                 190         


Gln Ile Arg Val Arg Cys Asp Glu Asn Tyr Tyr Ser Ala Thr Cys Asn 
        195                 200                 205             


Lys Phe Cys Arg Pro Arg Asn Asp Phe Phe Gly His Tyr Thr Cys Asp 
    210                 215                 220                 


Gln Tyr Gly Asn Lys Ala Cys Met Asp Gly Trp Met Gly Lys Glu Cys 
225                 230                 235                 240 


Lys Glu Ala Val Cys Lys Gln Gly Cys Asn Leu Leu His Gly Gly Cys 
                245                 250                 255     


Thr Val Pro Gly Glu Cys Arg Cys Ser Tyr Gly Trp Gln Gly Arg Phe 
            260                 265                 270         


Cys Asp Glu Cys Val Pro Tyr Pro Gly Cys Val His Gly Ser Cys Val 
        275                 280                 285             


Glu Pro Trp Gln Cys Asn Cys Glu Thr Asn Trp Gly Gly Leu Leu Cys 
    290                 295                 300                 


Asp Lys Asp Leu Asn Tyr Cys Gly Ser His His Pro Cys Thr Asn Gly 
305                 310                 315                 320 


Gly Thr Cys Ile Asn Ala Glu Pro Asp Gln Tyr Arg Cys Thr Cys Pro 
                325                 330                 335     


Asp Gly Tyr Ser Gly Arg Asn Cys Glu Lys Ala Glu His Ala Cys Thr 
            340                 345                 350         


Ser Asn Pro Cys Ala Asn Gly Gly Ser Cys His Glu Val Pro Ser Gly 
        355                 360                 365             


Phe Glu Cys His Cys Pro Ser Gly Trp Ser Gly Pro Thr Cys Ala Leu 
    370                 375                 380                 


Asp Ile Asp Glu Cys Ala Ser Asn Pro Cys Ala Ala Gly Gly Thr Cys 
385                 390                 395                 400 


Val Asp Gln Val Asp Gly Phe Glu Cys Ile Cys Pro Glu Gln Trp Val 
                405                 410                 415     


Gly Ala Thr Cys Gln Leu Asp Ala Asn Glu Cys Glu Gly Lys Pro Cys 
            420                 425                 430         


Leu Asn Ala Phe Ser Cys Lys Asn Leu Ile Gly Gly Tyr Tyr Cys Asp 
        435                 440                 445             


Cys Ile Pro Gly Trp Lys Gly Ile Asn Cys His Ile Asn Val Asn Asp 
    450                 455                 460                 


Cys Arg Gly Gln Cys Gln His Gly Gly Thr Cys Lys Asp Leu Val Asn 
465                 470                 475                 480 


Gly Tyr Gln Cys Val Cys Pro Arg Gly Phe Gly Gly Arg His Cys Glu 
                485                 490                 495     


Leu Glu Arg Asp Glu Cys Ala Ser Ser Pro Cys His Ser Gly Gly Leu 
            500                 505                 510         


Cys Glu Asp Leu Ala Asp Gly Phe His Cys His Cys Pro Gln Gly Phe 
        515                 520                 525             


Ser Gly Pro Leu Cys Glu Val Asp Val Asp Leu Cys Glu Pro Ser Pro 
    530                 535                 540                 


Cys Arg Asn Gly Ala Arg Cys Tyr Asn Leu Glu Gly Asp Tyr Tyr Cys 
545                 550                 555                 560 


Ala Cys Pro Asp Asp Phe Gly Gly Lys Asn Cys Ser Val Pro Arg Glu 
                565                 570                 575     


Pro Cys Pro Gly Gly Ala Cys Arg Val Ile Asp Gly Cys Gly Ser Asp 
            580                 585                 590         


Ala Gly Pro Gly Met Pro Gly Thr Ala Ala Ser Gly Val Cys Gly Pro 
        595                 600                 605             


His Gly Arg Cys Val Ser Gln Pro Gly Gly Asn Phe Ser Cys Ile Cys 
    610                 615                 620                 


Asp Ser Gly Phe Thr Gly Thr Tyr Cys His Glu Asn Ile Asp Asp Cys 
625                 630                 635                 640 


Leu Gly Gln Pro Cys Arg Asn Gly Gly Thr Cys Ile Asp Glu Val Asp 
                645                 650                 655     


Ala Phe Arg Cys Phe Cys Pro Ser Gly Trp Glu Gly Glu Leu Cys Asp 
            660                 665                 670         


Thr Asn Pro Asn Asp Cys Leu Pro Asp Pro Cys His Ser Arg Gly Arg 
        675                 680                 685             


Cys Tyr Asp Leu Val Asn Asp Phe Tyr Cys Ala Cys Asp Asp Gly Trp 
    690                 695                 700                 


Lys Gly Lys Thr Cys His Ser Arg Glu Phe Gln Cys Asp Ala Tyr Thr 
705                 710                 715                 720 


Cys Ser Asn Gly Gly Thr Cys Tyr Asp Ser Gly Asp Thr Phe Arg Cys 
                725                 730                 735     


Ala Cys Pro Pro Gly Trp Lys Gly Ser Thr Cys Ala Val Ala Lys Asn 
            740                 745                 750         


Ser Ser Cys Leu Pro Asn Pro Cys Val Asn Gly Gly Thr Cys Val Gly 
        755                 760                 765             


Ser Gly Ala Ser Phe Ser Cys Ile Cys Arg Asp Gly Trp Glu Gly Arg 
    770                 775                 780                 


Thr Cys Thr His Asn Thr Asn Asp Cys Asn Pro Leu Pro Cys Tyr Asn 
785                 790                 795                 800 


Gly Gly Ile Cys Val Asp Gly Val Asn Trp Phe Arg Cys Glu Cys Ala 
                805                 810                 815     


Pro Gly Phe Ala Gly Pro Asp Cys Arg Ile Asn Ile Asp Glu Cys Gln 
            820                 825                 830         


Ser Ser Pro Cys Ala Tyr Gly Ala Thr Cys Val Asp Glu Ile Asn Gly 
        835                 840                 845             


Tyr Arg Cys Ser Cys Pro Pro Gly Arg Ala Gly Pro Arg Cys Gln Glu 
    850                 855                 860                 


Val Ile Gly Phe Gly Arg Ser Cys Trp Ser Arg Gly Thr Pro Phe Pro 
865                 870                 875                 880 


His Gly Ser Ser Trp Val Glu Asp Cys Asn Ser Cys Arg Cys Leu Asp 
                885                 890                 895     


Gly Arg Arg Asp Cys Ser Lys Val Trp Cys Gly Trp Lys Pro Cys Leu 
            900                 905                 910         


Leu Ala Gly Gln Pro Glu Ala Leu Ser Ala Gln Cys Pro Leu Gly Gln 
        915                 920                 925             


Arg Cys Leu Glu Lys Ala Pro Gly Gln Cys Leu Arg Pro Pro Cys Glu 
    930                 935                 940                 


Ala Trp Gly Glu Cys Gly Ala Glu Glu Pro Pro Ser Thr Pro Cys Leu 
945                 950                 955                 960 


Pro Arg Ser Gly His Leu Asp Asn Asn Cys Ala Arg Leu Thr Leu His 
                965                 970                 975     


Phe Asn Arg Asp His Val Pro Gln Gly Thr Thr Val Gly Ala Ile Cys 
            980                 985                 990         


Ser Gly Ile Arg Ser Leu Pro Ala  Thr Arg Ala Val Ala  Arg Asp Arg 
        995                 1000                 1005             


Leu Leu  Val Leu Leu Cys Asp  Arg Ala Ser Ser Gly  Ala Ser Ala 
    1010                 1015                 1020             


Val Glu  Val Ala Val Ser Phe  Ser Pro Ala Arg Asp  Leu Pro Asp 
    1025                 1030                 1035             


Ser Ser  Leu Ile Gln Gly Ala  Ala His Ala Ile Val  Ala Ala Ile 
    1040                 1045                 1050             


Thr Gln  Arg Gly Asn Ser Ser  Leu Leu Leu Ala Val  Thr Glu Val 
    1055                 1060                 1065             


Lys Val  Glu Thr Val Val Thr  Gly Gly Ser Ser Thr  Gly Leu Leu 
    1070                 1075                 1080             


Val Pro  Val Leu Cys Gly Ala  Phe Ser Val Leu Trp  Leu Ala Cys 
    1085                 1090                 1095             


Val Val  Leu Cys Val Trp Trp  Thr Arg Lys Arg Arg  Lys Glu Arg 
    1100                 1105                 1110             


Glu Arg  Ser Arg Leu Pro Arg  Glu Glu Ser Ala Asn  Asn Gln Trp 
    1115                 1120                 1125             


Ala Pro  Leu Asn Pro Ile Arg  Asn Pro Ile Glu Arg  Pro Gly Gly 
    1130                 1135                 1140             


His Lys  Asp Val Leu Tyr Gln  Cys Lys Asn Phe Thr  Pro Pro Pro 
    1145                 1150                 1155             


Arg Arg  Ala Asp Glu Ala Leu  Pro Gly Pro Ala Gly  His Ala Ala 
    1160                 1165                 1170             


Val Arg  Glu Asp Glu Glu Asp  Glu Asp Leu Gly Arg  Gly Glu Glu 
    1175                 1180                 1185             


Asp Ser  Leu Glu Ala Glu Lys  Phe Leu Ser His Lys  Phe Thr Lys 
    1190                 1195                 1200             


Asp Pro  Gly Arg Ser Pro Gly  Arg Pro Ala His Trp  Ala Ser Gly 
    1205                 1210                 1215             


Pro Lys  Val Asp Asn Arg Ala  Val Arg Ser Ile Asn  Glu Ala Arg 
    1220                 1225                 1230             


Tyr Ala  Gly Lys Glu 
    1235             


<210>  206
<211>  1074
<212>  PRT
<213>  Homo sapiens

<400>  206

Met Thr Leu Ala Thr Asp Pro Thr Asp Gly Ser Ile Leu Ala Cys Asp 
1               5                   10                  15      


Pro Gly Leu Ser Arg Thr Cys Asp Gln Asn Thr Tyr Leu Ser Gly Leu 
            20                  25                  30          


Cys Tyr Leu Phe Arg Gln Asn Leu Gln Gly Pro Met Leu Gln Gly Arg 
        35                  40                  45              


Pro Gly Phe Gln Glu Cys Ile Lys Gly Asn Val Asp Leu Val Phe Leu 
    50                  55                  60                  


Phe Asp Gly Ser Met Ser Leu Gln Pro Asp Glu Phe Gln Lys Ile Leu 
65                  70                  75                  80  


Asp Phe Met Lys Asp Val Met Lys Lys Leu Ser Asn Thr Ser Tyr Gln 
                85                  90                  95      


Phe Ala Ala Val Gln Phe Ser Thr Ser Tyr Lys Thr Glu Phe Asp Phe 
            100                 105                 110         


Ser Asp Tyr Val Lys Arg Lys Asp Pro Asp Ala Leu Leu Lys His Val 
        115                 120                 125             


Lys His Met Leu Leu Leu Thr Asn Thr Phe Gly Ala Ile Asn Tyr Val 
    130                 135                 140                 


Ala Thr Glu Val Phe Arg Glu Glu Leu Gly Ala Arg Pro Asp Ala Thr 
145                 150                 155                 160 


Lys Val Leu Ile Ile Ile Thr Asp Gly Glu Ala Thr Asp Ser Gly Asn 
                165                 170                 175     


Ile Asp Ala Ala Lys Asp Ile Ile Arg Tyr Ile Ile Gly Ile Gly Lys 
            180                 185                 190         


His Phe Gln Thr Lys Glu Ser Gln Glu Thr Leu His Lys Phe Ala Ser 
        195                 200                 205             


Lys Pro Ala Ser Glu Phe Val Lys Ile Leu Asp Thr Phe Glu Lys Leu 
    210                 215                 220                 


Lys Asp Leu Phe Thr Glu Leu Gln Lys Lys Ile Tyr Val Ile Glu Gly 
225                 230                 235                 240 


Thr Ser Lys Gln Asp Leu Thr Ser Phe Asn Met Glu Leu Ser Ser Ser 
                245                 250                 255     


Gly Ile Ser Ala Asp Leu Ser Arg Gly His Ala Val Val Gly Ala Val 
            260                 265                 270         


Gly Ala Lys Asp Trp Ala Gly Gly Phe Leu Asp Leu Lys Ala Asp Leu 
        275                 280                 285             


Gln Asp Asp Thr Phe Ile Gly Asn Glu Pro Leu Thr Pro Glu Val Arg 
    290                 295                 300                 


Ala Gly Tyr Leu Gly Tyr Thr Val Thr Trp Leu Pro Ser Arg Gln Lys 
305                 310                 315                 320 


Thr Ser Leu Leu Ala Ser Gly Ala Pro Arg Tyr Gln His Met Gly Arg 
                325                 330                 335     


Val Leu Leu Phe Gln Glu Pro Gln Gly Gly Gly His Trp Ser Gln Val 
            340                 345                 350         


Gln Thr Ile His Gly Thr Gln Ile Gly Ser Tyr Phe Gly Gly Glu Leu 
        355                 360                 365             


Cys Gly Val Asp Val Asp Gln Asp Gly Glu Thr Glu Leu Leu Leu Ile 
    370                 375                 380                 


Gly Ala Pro Leu Phe Tyr Gly Glu Gln Arg Gly Gly Arg Val Phe Ile 
385                 390                 395                 400 


Tyr Gln Arg Arg Gln Leu Gly Phe Glu Glu Val Ser Glu Leu Gln Gly 
                405                 410                 415     


Asp Pro Gly Tyr Pro Leu Gly Arg Phe Gly Glu Ala Ile Thr Ala Leu 
            420                 425                 430         


Thr Asp Ile Asn Gly Asp Gly Leu Val Asp Val Ala Val Gly Ala Pro 
        435                 440                 445             


Leu Glu Glu Gln Gly Ala Val Tyr Ile Phe Asn Gly Arg His Gly Gly 
    450                 455                 460                 


Leu Ser Pro Gln Pro Ser Gln Arg Ile Glu Gly Thr Gln Val Leu Ser 
465                 470                 475                 480 


Gly Ile Gln Trp Phe Gly Arg Ser Ile His Gly Val Lys Asp Leu Glu 
                485                 490                 495     


Gly Asp Gly Leu Ala Asp Val Ala Val Gly Ala Glu Ser Gln Met Ile 
            500                 505                 510         


Val Leu Ser Ser Arg Pro Val Val Asp Met Val Thr Leu Met Ser Phe 
        515                 520                 525             


Ser Pro Ala Glu Ile Pro Val His Glu Val Glu Cys Ser Tyr Ser Thr 
    530                 535                 540                 


Ser Asn Lys Met Lys Glu Gly Val Asn Ile Thr Ile Cys Phe Gln Ile 
545                 550                 555                 560 


Lys Ser Leu Ile Pro Gln Phe Gln Gly Arg Leu Val Ala Asn Leu Thr 
                565                 570                 575     


Tyr Thr Leu Gln Leu Asp Gly His Arg Thr Arg Arg Arg Gly Leu Phe 
            580                 585                 590         


Pro Gly Gly Arg His Glu Leu Arg Arg Asn Ile Ala Val Thr Thr Ser 
        595                 600                 605             


Met Ser Cys Thr Asp Phe Ser Phe His Phe Pro Val Cys Val Gln Asp 
    610                 615                 620                 


Leu Ile Ser Pro Ile Asn Val Ser Leu Asn Phe Ser Leu Trp Glu Glu 
625                 630                 635                 640 


Glu Gly Thr Pro Arg Asp Gln Arg Ala Gln Gly Lys Asp Ile Pro Pro 
                645                 650                 655     


Ile Leu Arg Pro Ser Leu His Ser Glu Thr Trp Glu Ile Pro Phe Glu 
            660                 665                 670         


Lys Asn Cys Gly Glu Asp Lys Lys Cys Glu Ala Asn Leu Arg Val Ser 
        675                 680                 685             


Phe Ser Pro Ala Arg Ser Arg Ala Leu Arg Leu Thr Ala Phe Ala Ser 
    690                 695                 700                 


Leu Ser Val Glu Leu Ser Leu Ser Asn Leu Glu Glu Asp Ala Tyr Trp 
705                 710                 715                 720 


Val Gln Leu Asp Leu His Phe Pro Pro Gly Leu Ser Phe Arg Lys Val 
                725                 730                 735     


Glu Met Leu Lys Pro His Ser Gln Ile Pro Val Ser Cys Glu Glu Leu 
            740                 745                 750         


Pro Glu Glu Ser Arg Leu Leu Ser Arg Ala Leu Ser Cys Asn Val Ser 
        755                 760                 765             


Ser Pro Ile Phe Lys Ala Gly His Ser Val Ala Leu Gln Met Met Phe 
    770                 775                 780                 


Asn Thr Leu Val Asn Ser Ser Trp Gly Asp Ser Val Glu Leu His Ala 
785                 790                 795                 800 


Asn Val Thr Cys Asn Asn Glu Asp Ser Asp Leu Leu Glu Asp Asn Ser 
                805                 810                 815     


Ala Thr Thr Ile Ile Pro Ile Leu Tyr Pro Ile Asn Ile Leu Ile Gln 
            820                 825                 830         


Asp Gln Glu Asp Ser Thr Leu Tyr Val Ser Phe Thr Pro Lys Gly Pro 
        835                 840                 845             


Lys Ile His Gln Val Lys His Met Tyr Gln Val Arg Ile Gln Pro Ser 
    850                 855                 860                 


Ile His Asp His Asn Ile Pro Thr Leu Glu Ala Val Val Gly Val Pro 
865                 870                 875                 880 


Gln Pro Pro Ser Glu Gly Pro Ile Thr His Gln Trp Ser Val Gln Met 
                885                 890                 895     


Glu Pro Pro Val Pro Cys His Tyr Glu Asp Leu Glu Arg Leu Pro Asp 
            900                 905                 910         


Ala Ala Glu Pro Cys Leu Pro Gly Ala Leu Phe Arg Cys Pro Val Val 
        915                 920                 925             


Phe Arg Gln Glu Ile Leu Val Gln Val Ile Gly Thr Leu Glu Leu Val 
    930                 935                 940                 


Gly Glu Ile Glu Ala Ser Ser Met Phe Ser Leu Cys Ser Ser Leu Ser 
945                 950                 955                 960 


Ile Ser Phe Asn Ser Ser Lys His Phe His Leu Tyr Gly Ser Asn Ala 
                965                 970                 975     


Ser Leu Ala Gln Val Val Met Lys Val Asp Val Val Tyr Glu Lys Gln 
            980                 985                 990         


Met Leu Tyr Leu Tyr Val Leu Ser  Gly Ile Gly Gly Leu  Leu Leu Leu 
        995                 1000                 1005             


Leu Leu  Ile Phe Ile Val Leu  Tyr Lys Val Gly Phe  Phe Lys Arg 
    1010                 1015                 1020             


Asn Leu  Lys Glu Lys Met Glu  Ala Gly Arg Gly Val  Pro Asn Gly 
    1025                 1030                 1035             


Ile Pro  Ala Glu Asp Ser Glu  Gln Leu Ala Ser Gly  Gln Glu Ala 
    1040                 1045                 1050             


Gly Asp  Pro Gly Cys Leu Lys  Pro Leu His Glu Lys  Asp Ser Glu 
    1055                 1060                 1065             


Ser Gly  Gly Gly Lys Asp 
    1070                 


<210>  207
<211>  1153
<212>  PRT
<213>  Homo sapiens

<400>  207

Met Ala Leu Arg Val Leu Leu Leu Thr Ala Leu Thr Leu Cys His Gly 
1               5                   10                  15      


Phe Asn Leu Asp Thr Glu Asn Ala Met Thr Phe Gln Glu Asn Ala Arg 
            20                  25                  30          


Gly Phe Gly Gln Ser Val Val Gln Leu Gln Gly Ser Arg Val Val Val 
        35                  40                  45              


Gly Ala Pro Gln Glu Ile Val Ala Ala Asn Gln Arg Gly Ser Leu Tyr 
    50                  55                  60                  


Gln Cys Asp Tyr Ser Thr Gly Ser Cys Glu Pro Ile Arg Leu Gln Val 
65                  70                  75                  80  


Pro Val Glu Ala Val Asn Met Ser Leu Gly Leu Ser Leu Ala Ala Thr 
                85                  90                  95      


Thr Ser Pro Pro Gln Leu Leu Ala Cys Gly Pro Thr Val His Gln Thr 
            100                 105                 110         


Cys Ser Glu Asn Thr Tyr Val Lys Gly Leu Cys Phe Leu Phe Gly Ser 
        115                 120                 125             


Asn Leu Arg Gln Gln Pro Gln Lys Phe Pro Glu Ala Leu Arg Gly Cys 
    130                 135                 140                 


Pro Gln Glu Asp Ser Asp Ile Ala Phe Leu Ile Asp Gly Ser Gly Ser 
145                 150                 155                 160 


Ile Ile Pro His Asp Phe Arg Arg Met Lys Glu Phe Val Ser Thr Val 
                165                 170                 175     


Met Glu Gln Leu Lys Lys Ser Lys Thr Leu Phe Ser Leu Met Gln Tyr 
            180                 185                 190         


Ser Glu Glu Phe Arg Ile His Phe Thr Phe Lys Glu Phe Gln Asn Asn 
        195                 200                 205             


Pro Asn Pro Arg Ser Leu Val Lys Pro Ile Thr Gln Leu Leu Gly Arg 
    210                 215                 220                 


Thr His Thr Ala Thr Gly Ile Arg Lys Val Val Arg Glu Leu Phe Asn 
225                 230                 235                 240 


Ile Thr Asn Gly Ala Arg Lys Asn Ala Phe Lys Ile Leu Val Val Ile 
                245                 250                 255     


Thr Asp Gly Glu Lys Phe Gly Asp Pro Leu Gly Tyr Glu Asp Val Ile 
            260                 265                 270         


Pro Glu Ala Asp Arg Glu Gly Val Ile Arg Tyr Val Ile Gly Val Gly 
        275                 280                 285             


Asp Ala Phe Arg Ser Glu Lys Ser Arg Gln Glu Leu Asn Thr Ile Ala 
    290                 295                 300                 


Ser Lys Pro Pro Arg Asp His Val Phe Gln Val Asn Asn Phe Glu Ala 
305                 310                 315                 320 


Leu Lys Thr Ile Gln Asn Gln Leu Arg Glu Lys Ile Phe Ala Ile Glu 
                325                 330                 335     


Gly Thr Gln Thr Gly Ser Ser Ser Ser Phe Glu His Glu Met Ser Gln 
            340                 345                 350         


Glu Gly Phe Ser Ala Ala Ile Thr Ser Asn Gly Pro Leu Leu Ser Thr 
        355                 360                 365             


Val Gly Ser Tyr Asp Trp Ala Gly Gly Val Phe Leu Tyr Thr Ser Lys 
    370                 375                 380                 


Glu Lys Ser Thr Phe Ile Asn Met Thr Arg Val Asp Ser Asp Met Asn 
385                 390                 395                 400 


Asp Ala Tyr Leu Gly Tyr Ala Ala Ala Ile Ile Leu Arg Asn Arg Val 
                405                 410                 415     


Gln Ser Leu Val Leu Gly Ala Pro Arg Tyr Gln His Ile Gly Leu Val 
            420                 425                 430         


Ala Met Phe Arg Gln Asn Thr Gly Met Trp Glu Ser Asn Ala Asn Val 
        435                 440                 445             


Lys Gly Thr Gln Ile Gly Ala Tyr Phe Gly Ala Ser Leu Cys Ser Val 
    450                 455                 460                 


Asp Val Asp Ser Asn Gly Ser Thr Asp Leu Val Leu Ile Gly Ala Pro 
465                 470                 475                 480 


His Tyr Tyr Glu Gln Thr Arg Gly Gly Gln Val Ser Val Cys Pro Leu 
                485                 490                 495     


Pro Arg Gly Gln Arg Ala Arg Trp Gln Cys Asp Ala Val Leu Tyr Gly 
            500                 505                 510         


Glu Gln Gly Gln Pro Trp Gly Arg Phe Gly Ala Ala Leu Thr Val Leu 
        515                 520                 525             


Gly Asp Val Asn Gly Asp Lys Leu Thr Asp Val Ala Ile Gly Ala Pro 
    530                 535                 540                 


Gly Glu Glu Asp Asn Arg Gly Ala Val Tyr Leu Phe His Gly Thr Ser 
545                 550                 555                 560 


Gly Ser Gly Ile Ser Pro Ser His Ser Gln Arg Ile Ala Gly Ser Lys 
                565                 570                 575     


Leu Ser Pro Arg Leu Gln Tyr Phe Gly Gln Ser Leu Ser Gly Gly Gln 
            580                 585                 590         


Asp Leu Thr Met Asp Gly Leu Val Asp Leu Thr Val Gly Ala Gln Gly 
        595                 600                 605             


His Val Leu Leu Leu Arg Ser Gln Pro Val Leu Arg Val Lys Ala Ile 
    610                 615                 620                 


Met Glu Phe Asn Pro Arg Glu Val Ala Arg Asn Val Phe Glu Cys Asn 
625                 630                 635                 640 


Asp Gln Val Val Lys Gly Lys Glu Ala Gly Glu Val Arg Val Cys Leu 
                645                 650                 655     


His Val Gln Lys Ser Thr Arg Asp Arg Leu Arg Glu Gly Gln Ile Gln 
            660                 665                 670         


Ser Val Val Thr Tyr Asp Leu Ala Leu Asp Ser Gly Arg Pro His Ser 
        675                 680                 685             


Arg Ala Val Phe Asn Glu Thr Lys Asn Ser Thr Arg Arg Gln Thr Gln 
    690                 695                 700                 


Val Leu Gly Leu Thr Gln Thr Cys Glu Thr Leu Lys Leu Gln Leu Pro 
705                 710                 715                 720 


Asn Cys Ile Glu Asp Pro Val Ser Pro Ile Val Leu Arg Leu Asn Phe 
                725                 730                 735     


Ser Leu Val Gly Thr Pro Leu Ser Ala Phe Gly Asn Leu Arg Pro Val 
            740                 745                 750         


Leu Ala Glu Asp Ala Gln Arg Leu Phe Thr Ala Leu Phe Pro Phe Glu 
        755                 760                 765             


Lys Asn Cys Gly Asn Asp Asn Ile Cys Gln Asp Asp Leu Ser Ile Thr 
    770                 775                 780                 


Phe Ser Phe Met Ser Leu Asp Cys Leu Val Val Gly Gly Pro Arg Glu 
785                 790                 795                 800 


Phe Asn Val Thr Val Thr Val Arg Asn Asp Gly Glu Asp Ser Tyr Arg 
                805                 810                 815     


Thr Gln Val Thr Phe Phe Phe Pro Leu Asp Leu Ser Tyr Arg Lys Val 
            820                 825                 830         


Ser Thr Leu Gln Asn Gln Arg Ser Gln Arg Ser Trp Arg Leu Ala Cys 
        835                 840                 845             


Glu Ser Ala Ser Ser Thr Glu Val Ser Gly Ala Leu Lys Ser Thr Ser 
    850                 855                 860                 


Cys Ser Ile Asn His Pro Ile Phe Pro Glu Asn Ser Glu Val Thr Phe 
865                 870                 875                 880 


Asn Ile Thr Phe Asp Val Asp Ser Lys Ala Ser Leu Gly Asn Lys Leu 
                885                 890                 895     


Leu Leu Lys Ala Asn Val Thr Ser Glu Asn Asn Met Pro Arg Thr Asn 
            900                 905                 910         


Lys Thr Glu Phe Gln Leu Glu Leu Pro Val Lys Tyr Ala Val Tyr Met 
        915                 920                 925             


Val Val Thr Ser His Gly Val Ser Thr Lys Tyr Leu Asn Phe Thr Ala 
    930                 935                 940                 


Ser Glu Asn Thr Ser Arg Val Met Gln His Gln Tyr Gln Val Ser Asn 
945                 950                 955                 960 


Leu Gly Gln Arg Ser Leu Pro Ile Ser Leu Val Phe Leu Val Pro Val 
                965                 970                 975     


Arg Leu Asn Gln Thr Val Ile Trp Asp Arg Pro Gln Val Thr Phe Ser 
            980                 985                 990         


Glu Asn Leu Ser Ser Thr Cys His  Thr Lys Glu Arg Leu  Pro Ser His 
        995                 1000                 1005             


Ser Asp  Phe Leu Ala Glu Leu  Arg Lys Ala Pro Val  Val Asn Cys 
    1010                 1015                 1020             


Ser Ile  Ala Val Cys Gln Arg  Ile Gln Cys Asp Ile  Pro Phe Phe 
    1025                 1030                 1035             


Gly Ile  Gln Glu Glu Phe Asn  Ala Thr Leu Lys Gly  Asn Leu Ser 
    1040                 1045                 1050             


Phe Asp  Trp Tyr Ile Lys Thr  Ser His Asn His Leu  Leu Ile Val 
    1055                 1060                 1065             


Ser Thr  Ala Glu Ile Leu Phe  Asn Asp Ser Val Phe  Thr Leu Leu 
    1070                 1075                 1080             


Pro Gly  Gln Gly Ala Phe Val  Arg Ser Gln Thr Glu  Thr Lys Val 
    1085                 1090                 1095             


Glu Pro  Phe Glu Val Pro Asn  Pro Leu Pro Leu Ile  Val Gly Ser 
    1100                 1105                 1110             


Ser Val  Gly Gly Leu Leu Leu  Leu Ala Leu Ile Thr  Ala Ala Leu 
    1115                 1120                 1125             


Tyr Lys  Leu Gly Phe Phe Lys  Arg Gln Tyr Lys Asp  Met Met Ser 
    1130                 1135                 1140             


Glu Gly  Gly Pro Pro Gly Ala  Glu Pro Gln 
    1145                 1150             


<210>  208
<211>  1153
<212>  PRT
<213>  Homo sapiens

<400>  208

Met Ala Leu Arg Val Leu Leu Leu Thr Ala Leu Thr Leu Cys His Gly 
1               5                   10                  15      


Phe Asn Leu Asp Thr Glu Asn Ala Met Thr Phe Gln Glu Asn Ala Arg 
            20                  25                  30          


Gly Phe Gly Gln Ser Val Val Gln Leu Gln Gly Ser Arg Val Val Val 
        35                  40                  45              


Gly Ala Pro Gln Glu Ile Val Ala Ala Asn Gln Arg Gly Ser Leu Tyr 
    50                  55                  60                  


Gln Cys Asp Tyr Ser Thr Gly Ser Cys Glu Pro Ile Arg Leu Gln Val 
65                  70                  75                  80  


Pro Val Glu Ala Val Asn Met Ser Leu Gly Leu Ser Leu Ala Ala Thr 
                85                  90                  95      


Thr Ser Pro Pro Gln Leu Leu Ala Cys Gly Pro Thr Val His Gln Thr 
            100                 105                 110         


Cys Ser Glu Asn Thr Tyr Val Lys Gly Leu Cys Phe Leu Phe Gly Ser 
        115                 120                 125             


Asn Leu Arg Gln Gln Pro Gln Lys Phe Pro Glu Ala Leu Arg Gly Cys 
    130                 135                 140                 


Pro Gln Glu Asp Ser Asp Ile Ala Phe Leu Ile Asp Gly Ser Gly Ser 
145                 150                 155                 160 


Ile Ile Pro His Asp Phe Arg Arg Met Lys Glu Phe Val Ser Thr Val 
                165                 170                 175     


Met Glu Gln Leu Lys Lys Ser Lys Thr Leu Phe Ser Leu Met Gln Tyr 
            180                 185                 190         


Ser Glu Glu Phe Arg Ile His Phe Thr Phe Lys Glu Phe Gln Asn Asn 
        195                 200                 205             


Pro Asn Pro Arg Ser Leu Val Lys Pro Ile Thr Gln Leu Leu Gly Arg 
    210                 215                 220                 


Thr His Thr Ala Thr Gly Ile Arg Lys Val Val Arg Glu Leu Phe Asn 
225                 230                 235                 240 


Ile Thr Asn Gly Ala Arg Lys Asn Ala Phe Lys Ile Leu Val Val Ile 
                245                 250                 255     


Thr Asp Gly Glu Lys Phe Gly Asp Pro Leu Gly Tyr Glu Asp Val Ile 
            260                 265                 270         


Pro Glu Ala Asp Arg Glu Gly Val Ile Arg Tyr Val Ile Gly Val Gly 
        275                 280                 285             


Asp Ala Phe Arg Ser Glu Lys Ser Arg Gln Glu Leu Asn Thr Ile Ala 
    290                 295                 300                 


Ser Lys Pro Pro Arg Asp His Val Phe Gln Val Asn Asn Phe Glu Ala 
305                 310                 315                 320 


Leu Lys Thr Ile Gln Asn Gln Leu Arg Glu Lys Ile Phe Ala Ile Glu 
                325                 330                 335     


Gly Thr Gln Thr Gly Ser Ser Ser Ser Phe Glu His Glu Met Ser Gln 
            340                 345                 350         


Glu Gly Phe Ser Ala Ala Ile Thr Ser Asn Gly Pro Leu Leu Ser Thr 
        355                 360                 365             


Val Gly Ser Tyr Asp Trp Ala Gly Gly Val Phe Leu Tyr Thr Ser Lys 
    370                 375                 380                 


Glu Lys Ser Thr Phe Ile Asn Met Thr Arg Val Asp Ser Asp Met Asn 
385                 390                 395                 400 


Asp Ala Tyr Leu Gly Tyr Ala Ala Ala Ile Ile Leu Arg Asn Arg Val 
                405                 410                 415     


Gln Ser Leu Val Leu Gly Ala Pro Arg Tyr Gln His Ile Gly Leu Val 
            420                 425                 430         


Ala Met Phe Arg Gln Asn Thr Gly Met Trp Glu Ser Asn Ala Asn Val 
        435                 440                 445             


Lys Gly Thr Gln Ile Gly Ala Tyr Phe Gly Ala Ser Leu Cys Ser Val 
    450                 455                 460                 


Asp Val Asp Ser Asn Gly Ser Thr Asp Leu Val Leu Ile Gly Ala Pro 
465                 470                 475                 480 


His Tyr Tyr Glu Gln Thr Arg Gly Gly Gln Val Ser Val Cys Pro Leu 
                485                 490                 495     


Pro Arg Gly Gln Arg Ala Arg Trp Gln Cys Asp Ala Val Leu Tyr Gly 
            500                 505                 510         


Glu Gln Gly Gln Pro Trp Gly Arg Phe Gly Ala Ala Leu Thr Val Leu 
        515                 520                 525             


Gly Asp Val Asn Gly Asp Lys Leu Thr Asp Val Ala Ile Gly Ala Pro 
    530                 535                 540                 


Gly Glu Glu Asp Asn Arg Gly Ala Val Tyr Leu Phe His Gly Thr Ser 
545                 550                 555                 560 


Gly Ser Gly Ile Ser Pro Ser His Ser Gln Arg Ile Ala Gly Ser Lys 
                565                 570                 575     


Leu Ser Pro Arg Leu Gln Tyr Phe Gly Gln Ser Leu Ser Gly Gly Gln 
            580                 585                 590         


Asp Leu Thr Met Asp Gly Leu Val Asp Leu Thr Val Gly Ala Gln Gly 
        595                 600                 605             


His Val Leu Leu Leu Arg Ser Gln Pro Val Leu Arg Val Lys Ala Ile 
    610                 615                 620                 


Met Glu Phe Asn Pro Arg Glu Val Ala Arg Asn Val Phe Glu Cys Asn 
625                 630                 635                 640 


Asp Gln Val Val Lys Gly Lys Glu Ala Gly Glu Val Arg Val Cys Leu 
                645                 650                 655     


His Val Gln Lys Ser Thr Arg Asp Arg Leu Arg Glu Gly Gln Ile Gln 
            660                 665                 670         


Ser Val Val Thr Tyr Asp Leu Ala Leu Asp Ser Gly Arg Pro His Ser 
        675                 680                 685             


Arg Ala Val Phe Asn Glu Thr Lys Asn Ser Thr Arg Arg Gln Thr Gln 
    690                 695                 700                 


Val Leu Gly Leu Thr Gln Thr Cys Glu Thr Leu Lys Leu Gln Leu Pro 
705                 710                 715                 720 


Asn Cys Ile Glu Asp Pro Val Ser Pro Ile Val Leu Arg Leu Asn Phe 
                725                 730                 735     


Ser Leu Val Gly Thr Pro Leu Ser Ala Phe Gly Asn Leu Arg Pro Val 
            740                 745                 750         


Leu Ala Glu Asp Ala Gln Arg Leu Phe Thr Ala Leu Phe Pro Phe Glu 
        755                 760                 765             


Lys Asn Cys Gly Asn Asp Asn Ile Cys Gln Asp Asp Leu Ser Ile Thr 
    770                 775                 780                 


Phe Ser Phe Met Ser Leu Asp Cys Leu Val Val Gly Gly Pro Arg Glu 
785                 790                 795                 800 


Phe Asn Val Thr Val Thr Val Arg Asn Asp Gly Glu Asp Ser Tyr Arg 
                805                 810                 815     


Thr Gln Val Thr Phe Phe Phe Pro Leu Asp Leu Ser Tyr Arg Lys Val 
            820                 825                 830         


Ser Thr Leu Gln Asn Gln Arg Ser Gln Arg Ser Trp Arg Leu Ala Cys 
        835                 840                 845             


Glu Ser Ala Ser Ser Thr Glu Val Ser Gly Ala Leu Lys Ser Thr Ser 
    850                 855                 860                 


Cys Ser Ile Asn His Pro Ile Phe Pro Glu Asn Ser Glu Val Thr Phe 
865                 870                 875                 880 


Asn Ile Thr Phe Asp Val Asp Ser Lys Ala Ser Leu Gly Asn Lys Leu 
                885                 890                 895     


Leu Leu Lys Ala Asn Val Thr Ser Glu Asn Asn Met Pro Arg Thr Asn 
            900                 905                 910         


Lys Thr Glu Phe Gln Leu Glu Leu Pro Val Lys Tyr Ala Val Tyr Met 
        915                 920                 925             


Val Val Thr Ser His Gly Val Ser Thr Lys Tyr Leu Asn Phe Thr Ala 
    930                 935                 940                 


Ser Glu Asn Thr Ser Arg Val Met Gln His Gln Tyr Gln Val Ser Asn 
945                 950                 955                 960 


Leu Gly Gln Arg Ser Leu Pro Ile Ser Leu Val Phe Leu Val Pro Val 
                965                 970                 975     


Arg Leu Asn Gln Thr Val Ile Trp Asp Arg Pro Gln Val Thr Phe Ser 
            980                 985                 990         


Glu Asn Leu Ser Ser Thr Cys His  Thr Lys Glu Arg Leu  Pro Ser His 
        995                 1000                 1005             


Ser Asp  Phe Leu Ala Glu Leu  Arg Lys Ala Pro Val  Val Asn Cys 
    1010                 1015                 1020             


Ser Ile  Ala Val Cys Gln Arg  Ile Gln Cys Asp Ile  Pro Phe Phe 
    1025                 1030                 1035             


Gly Ile  Gln Glu Glu Phe Asn  Ala Thr Leu Lys Gly  Asn Leu Ser 
    1040                 1045                 1050             


Phe Asp  Trp Tyr Ile Lys Thr  Ser His Asn His Leu  Leu Ile Val 
    1055                 1060                 1065             


Ser Thr  Ala Glu Ile Leu Phe  Asn Asp Ser Val Phe  Thr Leu Leu 
    1070                 1075                 1080             


Pro Gly  Gln Gly Ala Phe Val  Arg Ser Gln Thr Glu  Thr Lys Val 
    1085                 1090                 1095             


Glu Pro  Phe Glu Val Pro Asn  Pro Leu Pro Leu Ile  Val Gly Ser 
    1100                 1105                 1110             


Ser Val  Gly Gly Leu Leu Leu  Leu Ala Leu Ile Thr  Ala Ala Leu 
    1115                 1120                 1125             


Tyr Lys  Leu Gly Phe Phe Lys  Arg Gln Tyr Lys Asp  Met Met Ser 
    1130                 1135                 1140             


Glu Gly  Gly Pro Pro Gly Ala  Glu Pro Gln 
    1145                 1150             


<210>  209
<211>  769
<212>  PRT
<213>  Homo sapiens

<400>  209

Met Leu Gly Leu Arg Pro Pro Leu Leu Ala Leu Val Gly Leu Leu Ser 
1               5                   10                  15      


Leu Gly Cys Val Leu Ser Gln Glu Cys Thr Lys Phe Lys Val Ser Ser 
            20                  25                  30          


Cys Arg Glu Cys Ile Glu Ser Gly Pro Gly Cys Thr Trp Cys Gln Lys 
        35                  40                  45              


Leu Asn Phe Thr Gly Pro Gly Asp Pro Asp Ser Ile Arg Cys Asp Thr 
    50                  55                  60                  


Arg Pro Gln Leu Leu Met Arg Gly Cys Ala Ala Asp Asp Ile Met Asp 
65                  70                  75                  80  


Pro Thr Ser Leu Ala Glu Thr Gln Glu Asp His Asn Gly Gly Gln Lys 
                85                  90                  95      


Gln Leu Ser Pro Gln Lys Val Thr Leu Tyr Leu Arg Pro Gly Gln Ala 
            100                 105                 110         


Ala Ala Phe Asn Val Thr Phe Arg Arg Ala Lys Gly Tyr Pro Ile Asp 
        115                 120                 125             


Leu Tyr Tyr Leu Met Asp Leu Ser Tyr Ser Met Leu Asp Asp Leu Arg 
    130                 135                 140                 


Asn Val Lys Lys Leu Gly Gly Asp Leu Leu Arg Ala Leu Asn Glu Ile 
145                 150                 155                 160 


Thr Glu Ser Gly Arg Ile Gly Phe Gly Ser Phe Val Asp Lys Thr Val 
                165                 170                 175     


Leu Pro Phe Val Asn Thr His Pro Asp Lys Leu Arg Asn Pro Cys Pro 
            180                 185                 190         


Asn Lys Glu Lys Glu Cys Gln Pro Pro Phe Ala Phe Arg His Val Leu 
        195                 200                 205             


Lys Leu Thr Asn Asn Ser Asn Gln Phe Gln Thr Glu Val Gly Lys Gln 
    210                 215                 220                 


Leu Ile Ser Gly Asn Leu Asp Ala Pro Glu Gly Gly Leu Asp Ala Met 
225                 230                 235                 240 


Met Gln Val Ala Ala Cys Pro Glu Glu Ile Gly Trp Arg Asn Val Thr 
                245                 250                 255     


Arg Leu Leu Val Phe Ala Thr Asp Asp Gly Phe His Phe Ala Gly Asp 
            260                 265                 270         


Gly Lys Leu Gly Ala Ile Leu Thr Pro Asn Asp Gly Arg Cys His Leu 
        275                 280                 285             


Glu Asp Asn Leu Tyr Lys Arg Ser Asn Glu Phe Asp Tyr Pro Ser Val 
    290                 295                 300                 


Gly Gln Leu Ala His Lys Leu Ala Glu Asn Asn Ile Gln Pro Ile Phe 
305                 310                 315                 320 


Ala Val Thr Ser Arg Met Val Lys Thr Tyr Glu Lys Leu Thr Glu Ile 
                325                 330                 335     


Ile Pro Lys Ser Ala Val Gly Glu Leu Ser Glu Asp Ser Ser Asn Val 
            340                 345                 350         


Val His Leu Ile Lys Asn Ala Tyr Asn Lys Leu Ser Ser Arg Val Phe 
        355                 360                 365             


Leu Asp His Asn Ala Leu Pro Asp Thr Leu Lys Val Thr Tyr Asp Ser 
    370                 375                 380                 


Phe Cys Ser Asn Gly Val Thr His Arg Asn Gln Pro Arg Gly Asp Cys 
385                 390                 395                 400 


Asp Gly Val Gln Ile Asn Val Pro Ile Thr Phe Gln Val Lys Val Thr 
                405                 410                 415     


Ala Thr Glu Cys Ile Gln Glu Gln Ser Phe Val Ile Arg Ala Leu Gly 
            420                 425                 430         


Phe Thr Asp Ile Val Thr Val Gln Val Leu Pro Gln Cys Glu Cys Arg 
        435                 440                 445             


Cys Arg Asp Gln Ser Arg Asp Arg Ser Leu Cys His Gly Lys Gly Phe 
    450                 455                 460                 


Leu Glu Cys Gly Ile Cys Arg Cys Asp Thr Gly Tyr Ile Gly Lys Asn 
465                 470                 475                 480 


Cys Glu Cys Gln Thr Gln Gly Arg Ser Ser Gln Glu Leu Glu Gly Ser 
                485                 490                 495     


Cys Arg Lys Asp Asn Asn Ser Ile Ile Cys Ser Gly Leu Gly Asp Cys 
            500                 505                 510         


Val Cys Gly Gln Cys Leu Cys His Thr Ser Asp Val Pro Gly Lys Leu 
        515                 520                 525             


Ile Tyr Gly Gln Tyr Cys Glu Cys Asp Thr Ile Asn Cys Glu Arg Tyr 
    530                 535                 540                 


Asn Gly Gln Val Cys Gly Gly Pro Gly Arg Gly Leu Cys Phe Cys Gly 
545                 550                 555                 560 


Lys Cys Arg Cys His Pro Gly Phe Glu Gly Ser Ala Cys Gln Cys Glu 
                565                 570                 575     


Arg Thr Thr Glu Gly Cys Leu Asn Pro Arg Arg Val Glu Cys Ser Gly 
            580                 585                 590         


Arg Gly Arg Cys Arg Cys Asn Val Cys Glu Cys His Ser Gly Tyr Gln 
        595                 600                 605             


Leu Pro Leu Cys Gln Glu Cys Pro Gly Cys Pro Ser Pro Cys Gly Lys 
    610                 615                 620                 


Tyr Ile Ser Cys Ala Glu Cys Leu Lys Phe Glu Lys Gly Pro Phe Gly 
625                 630                 635                 640 


Lys Asn Cys Ser Ala Ala Cys Pro Gly Leu Gln Leu Ser Asn Asn Pro 
                645                 650                 655     


Val Lys Gly Arg Thr Cys Lys Glu Arg Asp Ser Glu Gly Cys Trp Val 
            660                 665                 670         


Ala Tyr Thr Leu Glu Gln Gln Asp Gly Met Asp Arg Tyr Leu Ile Tyr 
        675                 680                 685             


Val Asp Glu Ser Arg Glu Cys Val Ala Gly Pro Asn Ile Ala Ala Ile 
    690                 695                 700                 


Val Gly Gly Thr Val Ala Gly Ile Val Leu Ile Gly Ile Leu Leu Leu 
705                 710                 715                 720 


Val Ile Trp Lys Ala Leu Ile His Leu Ser Asp Leu Arg Glu Tyr Arg 
                725                 730                 735     


Arg Phe Glu Lys Glu Lys Leu Lys Ser Gln Trp Asn Asn Asp Asn Pro 
            740                 745                 750         


Leu Phe Lys Ser Ala Thr Thr Thr Val Met Asn Pro Lys Phe Ala Glu 
        755                 760                 765             


Ser 
    


<210>  210
<211>  1039
<212>  PRT
<213>  Homo sapiens

<400>  210

Met Ala Arg Ala Leu Cys Pro Leu Gln Ala Leu Trp Leu Leu Glu Trp 
1               5                   10                  15      


Val Leu Leu Leu Leu Gly Pro Cys Ala Ala Pro Pro Ala Trp Ala Leu 
            20                  25                  30          


Asn Leu Asp Pro Val Gln Leu Thr Phe Tyr Ala Gly Pro Asn Gly Ser 
        35                  40                  45              


Gln Phe Gly Phe Ser Leu Asp Phe His Lys Asp Ser His Gly Arg Val 
    50                  55                  60                  


Ala Ile Val Val Gly Ala Pro Arg Thr Leu Gly Pro Ser Gln Glu Glu 
65                  70                  75                  80  


Thr Gly Gly Val Phe Leu Cys Pro Trp Arg Ala Glu Gly Gly Gln Cys 
                85                  90                  95      


Pro Ser Leu Leu Phe Asp Leu Arg Asp Glu Thr Arg Asn Val Gly Ser 
            100                 105                 110         


Gln Thr Leu Gln Thr Phe Lys Ala Arg Gln Gly Leu Gly Ala Ser Val 
        115                 120                 125             


Val Ser Trp Ser Asp Val Ile Val Ala Cys Ala Pro Trp Gln His Trp 
    130                 135                 140                 


Asn Val Leu Glu Lys Thr Glu Glu Ala Glu Lys Thr Pro Val Gly Ser 
145                 150                 155                 160 


Cys Phe Leu Ala Gln Pro Glu Ser Gly Arg Arg Ala Glu Tyr Ser Pro 
                165                 170                 175     


Cys Arg Gly Asn Thr Leu Ser Arg Ile Tyr Val Glu Asn Asp Phe Ser 
            180                 185                 190         


Trp Asp Lys Arg Tyr Cys Glu Ala Gly Phe Ser Ser Val Val Thr Gln 
        195                 200                 205             


Ala Gly Glu Leu Val Leu Gly Ala Pro Gly Gly Tyr Tyr Phe Leu Gly 
    210                 215                 220                 


Leu Leu Ala Gln Ala Pro Val Ala Asp Ile Phe Ser Ser Tyr Arg Pro 
225                 230                 235                 240 


Gly Ile Leu Leu Trp His Val Ser Ser Gln Ser Leu Ser Phe Asp Ser 
                245                 250                 255     


Ser Asn Pro Glu Tyr Phe Asp Gly Tyr Trp Gly Tyr Ser Val Ala Val 
            260                 265                 270         


Gly Glu Phe Asp Gly Asp Leu Asn Thr Thr Glu Tyr Val Val Gly Ala 
        275                 280                 285             


Pro Thr Trp Ser Trp Thr Leu Gly Ala Val Glu Ile Leu Asp Ser Tyr 
    290                 295                 300                 


Tyr Gln Arg Leu His Arg Leu Arg Gly Glu Gln Met Ala Ser Tyr Phe 
305                 310                 315                 320 


Gly His Ser Val Ala Val Thr Asp Val Asn Gly Asp Gly Arg His Asp 
                325                 330                 335     


Leu Leu Val Gly Ala Pro Leu Tyr Met Glu Ser Arg Ala Asp Arg Lys 
            340                 345                 350         


Leu Ala Glu Val Gly Arg Val Tyr Leu Phe Leu Gln Pro Arg Gly Pro 
        355                 360                 365             


His Ala Leu Gly Ala Pro Ser Leu Leu Leu Thr Gly Thr Gln Leu Tyr 
    370                 375                 380                 


Gly Arg Phe Gly Ser Ala Ile Ala Pro Leu Gly Asp Leu Asp Arg Asp 
385                 390                 395                 400 


Gly Tyr Asn Asp Ile Ala Val Ala Ala Pro Tyr Gly Gly Pro Ser Gly 
                405                 410                 415     


Arg Gly Gln Val Leu Val Phe Leu Gly Gln Ser Glu Gly Leu Arg Ser 
            420                 425                 430         


Arg Pro Ser Gln Val Leu Asp Ser Pro Phe Pro Thr Gly Ser Ala Phe 
        435                 440                 445             


Gly Phe Ser Leu Arg Gly Ala Val Asp Ile Asp Asp Asn Gly Tyr Pro 
    450                 455                 460                 


Asp Leu Ile Val Gly Ala Tyr Gly Ala Asn Gln Val Ala Val Tyr Arg 
465                 470                 475                 480 


Ala Gln Pro Val Val Lys Ala Ser Val Gln Leu Leu Val Gln Asp Ser 
                485                 490                 495     


Leu Asn Pro Ala Val Lys Ser Cys Val Leu Pro Gln Thr Lys Thr Pro 
            500                 505                 510         


Val Ser Cys Phe Asn Ile Gln Met Cys Val Gly Ala Thr Gly His Asn 
        515                 520                 525             


Ile Pro Gln Lys Leu Ser Leu Asn Ala Glu Leu Gln Leu Asp Arg Gln 
    530                 535                 540                 


Lys Pro Arg Gln Gly Arg Arg Val Leu Leu Leu Gly Ser Gln Gln Ala 
545                 550                 555                 560 


Gly Thr Thr Leu Asn Leu Asp Leu Gly Gly Lys His Ser Pro Ile Cys 
                565                 570                 575     


His Thr Thr Met Ala Phe Leu Arg Asp Glu Ala Asp Phe Arg Asp Lys 
            580                 585                 590         


Leu Ser Pro Ile Val Leu Ser Leu Asn Val Ser Leu Pro Pro Thr Glu 
        595                 600                 605             


Ala Gly Met Ala Pro Ala Val Val Leu His Gly Asp Thr His Val Gln 
    610                 615                 620                 


Glu Gln Thr Arg Ile Val Leu Asp Cys Gly Glu Asp Asp Val Cys Val 
625                 630                 635                 640 


Pro Gln Leu Gln Leu Thr Ala Ser Val Thr Gly Ser Pro Leu Leu Val 
                645                 650                 655     


Gly Ala Asp Asn Val Leu Glu Leu Gln Met Asp Ala Ala Asn Glu Gly 
            660                 665                 670         


Glu Gly Ala Tyr Glu Ala Glu Leu Ala Val His Leu Pro Gln Gly Ala 
        675                 680                 685             


His Tyr Met Arg Ala Leu Ser Asn Val Glu Gly Phe Glu Arg Leu Ile 
    690                 695                 700                 


Cys Asn Gln Lys Lys Glu Asn Glu Thr Arg Val Val Leu Cys Glu Leu 
705                 710                 715                 720 


Gly Asn Pro Met Lys Lys Asn Ala Gln Ile Gly Ile Ala Met Leu Val 
                725                 730                 735     


Ser Val Gly Asn Leu Glu Glu Ala Gly Glu Ser Val Ser Phe Gln Leu 
            740                 745                 750         


Gln Ile Arg Ser Lys Asn Ser Gln Asn Pro Asn Ser Lys Ile Val Leu 
        755                 760                 765             


Leu Asp Val Pro Val Arg Ala Glu Ala Gln Val Glu Leu Arg Gly Asn 
    770                 775                 780                 


Ser Phe Pro Ala Ser Leu Val Val Ala Ala Glu Glu Gly Glu Arg Glu 
785                 790                 795                 800 


Gln Asn Ser Leu Asp Ser Trp Gly Pro Lys Val Glu His Thr Tyr Glu 
                805                 810                 815     


Leu His Asn Asn Gly Pro Gly Thr Val Asn Gly Leu His Leu Ser Ile 
            820                 825                 830         


His Leu Pro Gly Gln Ser Gln Pro Ser Asp Leu Leu Tyr Ile Leu Asp 
        835                 840                 845             


Ile Gln Pro Gln Gly Gly Leu Gln Cys Phe Pro Gln Pro Pro Val Asn 
    850                 855                 860                 


Pro Leu Lys Val Asp Trp Gly Leu Pro Ile Pro Ser Pro Ser Pro Ile 
865                 870                 875                 880 


His Pro Ala His His Lys Arg Asp Arg Arg Gln Ile Phe Leu Pro Glu 
                885                 890                 895     


Pro Glu Gln Pro Ser Arg Leu Gln Asp Pro Val Leu Val Ser Cys Asp 
            900                 905                 910         


Ser Ala Pro Cys Thr Val Val Gln Cys Asp Leu Gln Glu Met Ala Arg 
        915                 920                 925             


Gly Gln Arg Ala Met Val Thr Val Leu Ala Phe Leu Trp Leu Pro Ser 
    930                 935                 940                 


Leu Tyr Gln Arg Pro Leu Asp Gln Phe Val Leu Gln Ser His Ala Trp 
945                 950                 955                 960 


Phe Asn Val Ser Ser Leu Pro Tyr Ala Val Pro Pro Leu Ser Leu Pro 
                965                 970                 975     


Arg Gly Glu Ala Gln Val Trp Thr Gln Leu Leu Arg Ala Leu Glu Glu 
            980                 985                 990         


Arg Ala Ile Pro Ile Trp Trp Val  Leu Val Gly Val Leu  Gly Gly Leu 
        995                 1000                 1005             


Leu Leu  Leu Thr Ile Leu Val  Leu Ala Met Trp Lys  Val Gly Phe 
    1010                 1015                 1020             


Phe Lys  Arg Asn Arg Pro Pro  Leu Glu Glu Asp Asp  Glu Glu Gly 
    1025                 1030                 1035             


Glu 
    


<210>  211
<211>  1012
<212>  PRT
<213>  Homo sapiens

<400>  211

Met Ala Phe Pro Pro Arg Arg Arg Leu Arg Leu Gly Pro Arg Gly Leu 
1               5                   10                  15      


Pro Leu Leu Leu Ser Gly Leu Leu Leu Pro Leu Cys Arg Ala Phe Asn 
            20                  25                  30          


Leu Asp Val Asp Ser Pro Ala Glu Tyr Ser Gly Pro Glu Gly Ser Tyr 
        35                  40                  45              


Phe Gly Phe Ala Val Asp Phe Phe Val Pro Ser Ala Ser Ser Arg Met 
    50                  55                  60                  


Phe Leu Leu Val Gly Ala Pro Lys Ala Asn Thr Thr Gln Pro Gly Ile 
65                  70                  75                  80  


Val Glu Gly Gly Gln Val Leu Lys Cys Asp Trp Ser Ser Thr Arg Arg 
                85                  90                  95      


Cys Gln Pro Ile Glu Phe Asp Ala Thr Gly Asn Arg Asp Tyr Ala Lys 
            100                 105                 110         


Asp Asp Pro Leu Glu Phe Lys Ser His Gln Trp Phe Gly Ala Ser Val 
        115                 120                 125             


Arg Ser Lys Gln Asp Lys Ile Leu Ala Cys Ala Pro Leu Tyr His Trp 
    130                 135                 140                 


Arg Thr Glu Met Lys Gln Glu Arg Glu Pro Val Gly Thr Cys Phe Leu 
145                 150                 155                 160 


Gln Asp Gly Thr Lys Thr Val Glu Tyr Ala Pro Cys Arg Ser Arg Gln 
                165                 170                 175     


Leu Ile Ser Asp Gln Val Ala Glu Ile Val Ser Lys Tyr Asp Pro Asn 
            180                 185                 190         


Val Tyr Ser Ile Lys Tyr Asn Asn Gln Leu Ala Thr Arg Thr Ala Gln 
        195                 200                 205             


Ala Ile Phe Asp Asp Ser Tyr Leu Gly Tyr Ser Val Ala Val Gly Asp 
    210                 215                 220                 


Phe Asn Gly Asp Gly Ile Asp Asp Phe Val Ser Gly Val Pro Arg Ala 
225                 230                 235                 240 


Ala Arg Thr Leu Gly Met Val Tyr Ile Tyr Asp Gly Lys Asn Met Ser 
                245                 250                 255     


Ser Leu Tyr Asn Phe Thr Gly Glu Gln Met Ala Ala Tyr Phe Gly Phe 
            260                 265                 270         


Ser Val Ala Ala Thr Asp Ile Asn Gly Asp Asp Tyr Ala Asp Val Phe 
        275                 280                 285             


Ile Gly Ala Pro Leu Phe Met Asp Arg Gly Ser Asp Gly Lys Leu Gln 
    290                 295                 300                 


Glu Val Gly Gln Val Ser Val Ser Leu Gln Arg Ala Ser Gly Asp Phe 
305                 310                 315                 320 


Gln Thr Thr Lys Leu Asn Gly Phe Glu Val Phe Ala Arg Phe Gly Ser 
                325                 330                 335     


Ala Ile Ala Pro Leu Gly Asp Leu Asp Gln Asp Gly Phe Asn Asp Ile 
            340                 345                 350         


Ala Ile Ala Ala Pro Tyr Gly Gly Glu Asp Lys Lys Gly Ile Val Tyr 
        355                 360                 365             


Ile Phe Asn Gly Arg Ser Thr Gly Leu Asn Ala Val Pro Ser Gln Ile 
    370                 375                 380                 


Leu Glu Gly Gln Trp Ala Ala Arg Ser Met Pro Pro Ser Phe Gly Tyr 
385                 390                 395                 400 


Ser Met Lys Gly Ala Thr Asp Ile Asp Lys Asn Gly Tyr Pro Asp Leu 
                405                 410                 415     


Ile Val Gly Ala Phe Gly Val Asp Arg Ala Ile Leu Tyr Arg Ala Arg 
            420                 425                 430         


Pro Val Ile Thr Val Asn Ala Gly Leu Glu Val Tyr Pro Ser Ile Leu 
        435                 440                 445             


Asn Gln Asp Asn Lys Thr Cys Ser Leu Pro Gly Thr Ala Leu Lys Val 
    450                 455                 460                 


Ser Cys Phe Asn Val Arg Phe Cys Leu Lys Ala Asp Gly Lys Gly Val 
465                 470                 475                 480 


Leu Pro Arg Lys Leu Asn Phe Gln Val Glu Leu Leu Leu Asp Lys Leu 
                485                 490                 495     


Lys Gln Lys Gly Ala Ile Arg Arg Ala Leu Phe Leu Tyr Ser Arg Ser 
            500                 505                 510         


Pro Ser His Ser Lys Asn Met Thr Ile Ser Arg Gly Gly Leu Met Gln 
        515                 520                 525             


Cys Glu Glu Leu Ile Ala Tyr Leu Arg Asp Glu Ser Glu Phe Arg Asp 
    530                 535                 540                 


Lys Leu Thr Pro Ile Thr Ile Phe Met Glu Tyr Arg Leu Asp Tyr Arg 
545                 550                 555                 560 


Thr Ala Ala Asp Thr Thr Gly Leu Gln Pro Ile Leu Asn Gln Phe Thr 
                565                 570                 575     


Pro Ala Asn Ile Ser Arg Gln Ala His Ile Leu Leu Asp Cys Gly Glu 
            580                 585                 590         


Asp Asn Val Cys Lys Pro Lys Leu Glu Val Ser Val Asp Ser Asp Gln 
        595                 600                 605             


Lys Lys Ile Tyr Ile Gly Asp Asp Asn Pro Leu Thr Leu Ile Val Lys 
    610                 615                 620                 


Ala Gln Asn Gln Gly Glu Gly Ala Tyr Glu Ala Glu Leu Ile Val Ser 
625                 630                 635                 640 


Ile Pro Leu Gln Ala Asp Phe Ile Gly Val Val Arg Asn Asn Glu Ala 
                645                 650                 655     


Leu Ala Arg Leu Ser Cys Ala Phe Lys Thr Glu Asn Gln Thr Arg Gln 
            660                 665                 670         


Val Val Cys Asp Leu Gly Asn Pro Met Lys Ala Gly Thr Gln Leu Leu 
        675                 680                 685             


Ala Gly Leu Arg Phe Ser Val His Gln Gln Ser Glu Met Asp Thr Ser 
    690                 695                 700                 


Val Lys Phe Asp Leu Gln Ile Gln Ser Ser Asn Leu Phe Asp Lys Val 
705                 710                 715                 720 


Ser Pro Val Val Ser His Lys Val Asp Leu Ala Val Leu Ala Ala Val 
                725                 730                 735     


Glu Ile Arg Gly Val Ser Ser Pro Asp His Ile Phe Leu Pro Ile Pro 
            740                 745                 750         


Asn Trp Glu His Lys Glu Asn Pro Glu Thr Glu Glu Asp Val Gly Pro 
        755                 760                 765             


Val Val Gln His Ile Tyr Glu Leu Arg Asn Asn Gly Pro Ser Ser Phe 
    770                 775                 780                 


Ser Lys Ala Met Leu His Leu Gln Trp Pro Tyr Lys Tyr Asn Asn Asn 
785                 790                 795                 800 


Thr Leu Leu Tyr Ile Leu His Tyr Asp Ile Asp Gly Pro Met Asn Cys 
                805                 810                 815     


Thr Ser Asp Met Glu Ile Asn Pro Leu Arg Ile Lys Ile Ser Ser Leu 
            820                 825                 830         


Gln Thr Thr Glu Lys Asn Asp Thr Val Ala Gly Gln Gly Glu Arg Asp 
        835                 840                 845             


His Leu Ile Thr Lys Arg Asp Leu Ala Leu Ser Glu Gly Asp Ile His 
    850                 855                 860                 


Thr Leu Gly Cys Gly Val Ala Gln Cys Leu Lys Ile Val Cys Gln Val 
865                 870                 875                 880 


Gly Arg Leu Asp Arg Gly Lys Ser Ala Ile Leu Tyr Val Lys Ser Leu 
                885                 890                 895     


Leu Trp Thr Glu Thr Phe Met Asn Lys Glu Asn Gln Asn His Ser Tyr 
            900                 905                 910         


Ser Leu Lys Ser Ser Ala Ser Phe Asn Val Ile Glu Phe Pro Tyr Lys 
        915                 920                 925             


Asn Leu Pro Ile Glu Asp Ile Thr Asn Ser Thr Leu Val Thr Thr Asn 
    930                 935                 940                 


Val Thr Trp Gly Ile Gln Pro Ala Pro Met Pro Val Pro Val Trp Val 
945                 950                 955                 960 


Ile Ile Leu Ala Val Leu Ala Gly Leu Leu Leu Leu Ala Val Leu Val 
                965                 970                 975     


Phe Val Met Tyr Arg Met Gly Phe Phe Lys Arg Val Arg Pro Pro Gln 
            980                 985                 990         


Glu Glu Gln Glu Arg Glu Gln Leu  Gln Pro His Glu Asn  Gly Glu Gly 
        995                 1000                 1005             


Asn Ser  Glu Thr 
    1010         


<210>  212
<211>  788
<212>  PRT
<213>  Homo sapiens

<400>  212

Met Arg Ala Arg Pro Arg Pro Arg Pro Leu Trp Ala Thr Val Leu Ala 
1               5                   10                  15      


Leu Gly Ala Leu Ala Gly Val Gly Val Gly Gly Pro Asn Ile Cys Thr 
            20                  25                  30          


Thr Arg Gly Val Ser Ser Cys Gln Gln Cys Leu Ala Val Ser Pro Met 
        35                  40                  45              


Cys Ala Trp Cys Ser Asp Glu Ala Leu Pro Leu Gly Ser Pro Arg Cys 
    50                  55                  60                  


Asp Leu Lys Glu Asn Leu Leu Lys Asp Asn Cys Ala Pro Glu Ser Ile 
65                  70                  75                  80  


Glu Phe Pro Val Ser Glu Ala Arg Val Leu Glu Asp Arg Pro Leu Ser 
                85                  90                  95      


Asp Lys Gly Ser Gly Asp Ser Ser Gln Val Thr Gln Val Ser Pro Gln 
            100                 105                 110         


Arg Ile Ala Leu Arg Leu Arg Pro Asp Asp Ser Lys Asn Phe Ser Ile 
        115                 120                 125             


Gln Val Arg Gln Val Glu Asp Tyr Pro Val Asp Ile Tyr Tyr Leu Met 
    130                 135                 140                 


Asp Leu Ser Tyr Ser Met Lys Asp Asp Leu Trp Ser Ile Gln Asn Leu 
145                 150                 155                 160 


Gly Thr Lys Leu Ala Thr Gln Met Arg Lys Leu Thr Ser Asn Leu Arg 
                165                 170                 175     


Ile Gly Phe Gly Ala Phe Val Asp Lys Pro Val Ser Pro Tyr Met Tyr 
            180                 185                 190         


Ile Ser Pro Pro Glu Ala Leu Glu Asn Pro Cys Tyr Asp Met Lys Thr 
        195                 200                 205             


Thr Cys Leu Pro Met Phe Gly Tyr Lys His Val Leu Thr Leu Thr Asp 
    210                 215                 220                 


Gln Val Thr Arg Phe Asn Glu Glu Val Lys Lys Gln Ser Val Ser Arg 
225                 230                 235                 240 


Asn Arg Asp Ala Pro Glu Gly Gly Phe Asp Ala Ile Met Gln Ala Thr 
                245                 250                 255     


Val Cys Asp Glu Lys Ile Gly Trp Arg Asn Asp Ala Ser His Leu Leu 
            260                 265                 270         


Val Phe Thr Thr Asp Ala Lys Thr His Ile Ala Leu Asp Gly Arg Leu 
        275                 280                 285             


Ala Gly Ile Val Gln Pro Asn Asp Gly Gln Cys His Val Gly Ser Asp 
    290                 295                 300                 


Asn His Tyr Ser Ala Ser Thr Thr Met Asp Tyr Pro Ser Leu Gly Leu 
305                 310                 315                 320 


Met Thr Glu Lys Leu Ser Gln Lys Asn Ile Asn Leu Ile Phe Ala Val 
                325                 330                 335     


Thr Glu Asn Val Val Asn Leu Tyr Gln Asn Tyr Ser Glu Leu Ile Pro 
            340                 345                 350         


Gly Thr Thr Val Gly Val Leu Ser Met Asp Ser Ser Asn Val Leu Gln 
        355                 360                 365             


Leu Ile Val Asp Ala Tyr Gly Lys Ile Arg Ser Lys Val Glu Leu Glu 
    370                 375                 380                 


Val Arg Asp Leu Pro Glu Glu Leu Ser Leu Ser Phe Asn Ala Thr Cys 
385                 390                 395                 400 


Leu Asn Asn Glu Val Ile Pro Gly Leu Lys Ser Cys Met Gly Leu Lys 
                405                 410                 415     


Ile Gly Asp Thr Val Ser Phe Ser Ile Glu Ala Lys Val Arg Gly Cys 
            420                 425                 430         


Pro Gln Glu Lys Glu Lys Ser Phe Thr Ile Lys Pro Val Gly Phe Lys 
        435                 440                 445             


Asp Ser Leu Ile Val Gln Val Thr Phe Asp Cys Asp Cys Ala Cys Gln 
    450                 455                 460                 


Ala Gln Ala Glu Pro Asn Ser His Arg Cys Asn Asn Gly Asn Gly Thr 
465                 470                 475                 480 


Phe Glu Cys Gly Val Cys Arg Cys Gly Pro Gly Trp Leu Gly Ser Gln 
                485                 490                 495     


Cys Glu Cys Ser Glu Glu Asp Tyr Arg Pro Ser Gln Gln Asp Glu Cys 
            500                 505                 510         


Ser Pro Arg Glu Gly Gln Pro Val Cys Ser Gln Arg Gly Glu Cys Leu 
        515                 520                 525             


Cys Gly Gln Cys Val Cys His Ser Ser Asp Phe Gly Lys Ile Thr Gly 
    530                 535                 540                 


Lys Tyr Cys Glu Cys Asp Asp Phe Ser Cys Val Arg Tyr Lys Gly Glu 
545                 550                 555                 560 


Met Cys Ser Gly His Gly Gln Cys Ser Cys Gly Asp Cys Leu Cys Asp 
                565                 570                 575     


Ser Asp Trp Thr Gly Tyr Tyr Cys Asn Cys Thr Thr Arg Thr Asp Thr 
            580                 585                 590         


Cys Met Ser Ser Asn Gly Leu Leu Cys Ser Gly Arg Gly Lys Cys Glu 
        595                 600                 605             


Cys Gly Ser Cys Val Cys Ile Gln Pro Gly Ser Tyr Gly Asp Thr Cys 
    610                 615                 620                 


Glu Lys Cys Pro Thr Cys Pro Asp Ala Cys Thr Phe Lys Lys Glu Cys 
625                 630                 635                 640 


Val Glu Cys Lys Lys Phe Asp Arg Gly Ala Leu His Asp Glu Asn Thr 
                645                 650                 655     


Cys Asn Arg Tyr Cys Arg Asp Glu Ile Glu Ser Val Lys Glu Leu Lys 
            660                 665                 670         


Asp Thr Gly Lys Asp Ala Val Asn Cys Thr Tyr Lys Asn Glu Asp Asp 
        675                 680                 685             


Cys Val Val Arg Phe Gln Tyr Tyr Glu Asp Ser Ser Gly Lys Ser Ile 
    690                 695                 700                 


Leu Tyr Val Val Glu Glu Pro Glu Cys Pro Lys Gly Pro Asp Ile Leu 
705                 710                 715                 720 


Val Val Leu Leu Ser Val Met Gly Ala Ile Leu Leu Ile Gly Leu Ala 
                725                 730                 735     


Ala Leu Leu Ile Trp Lys Leu Leu Ile Thr Ile His Asp Arg Lys Glu 
            740                 745                 750         


Phe Ala Lys Phe Glu Glu Glu Arg Ala Arg Ala Lys Trp Asp Thr Ala 
        755                 760                 765             


Asn Asn Pro Leu Tyr Lys Glu Ala Thr Ser Thr Phe Thr Asn Ile Thr 
    770                 775                 780                 


Tyr Arg Gly Thr 
785             


<210>  213
<211>  1752
<212>  PRT
<213>  Homo sapiens

<400>  213

Met Ala Gly Pro Arg Pro Ser Pro Trp Ala Arg Leu Leu Leu Ala Ala 
1               5                   10                  15      


Leu Ile Ser Val Ser Leu Ser Gly Thr Leu Ala Asn Arg Cys Lys Lys 
            20                  25                  30          


Ala Pro Val Lys Ser Cys Thr Glu Cys Val Arg Val Asp Lys Asp Cys 
        35                  40                  45              


Ala Tyr Cys Thr Asp Glu Met Phe Arg Asp Arg Arg Cys Asn Thr Gln 
    50                  55                  60                  


Ala Glu Leu Leu Ala Ala Gly Cys Gln Arg Glu Ser Ile Val Val Met 
65                  70                  75                  80  


Glu Ser Ser Phe Gln Ile Thr Glu Glu Thr Gln Ile Asp Thr Thr Leu 
                85                  90                  95      


Arg Arg Ser Gln Met Ser Pro Gln Gly Leu Arg Val Arg Leu Arg Pro 
            100                 105                 110         


Gly Glu Glu Arg His Phe Glu Leu Glu Val Phe Glu Pro Leu Glu Ser 
        115                 120                 125             


Pro Val Asp Leu Tyr Ile Leu Met Asp Phe Ser Asn Ser Met Ser Asp 
    130                 135                 140                 


Asp Leu Asp Asn Leu Lys Lys Met Gly Gln Asn Leu Ala Arg Val Leu 
145                 150                 155                 160 


Ser Gln Leu Thr Ser Asp Tyr Thr Ile Gly Phe Gly Lys Phe Val Asp 
                165                 170                 175     


Lys Val Ser Val Pro Gln Thr Asp Met Arg Pro Glu Lys Leu Lys Glu 
            180                 185                 190         


Pro Trp Pro Asn Ser Asp Pro Pro Phe Ser Phe Lys Asn Val Ile Ser 
        195                 200                 205             


Leu Thr Glu Asp Val Asp Glu Phe Arg Asn Lys Leu Gln Gly Glu Arg 
    210                 215                 220                 


Ile Ser Gly Asn Leu Asp Ala Pro Glu Gly Gly Phe Asp Ala Ile Leu 
225                 230                 235                 240 


Gln Thr Ala Val Cys Thr Arg Asp Ile Gly Trp Arg Pro Asp Ser Thr 
                245                 250                 255     


His Leu Leu Val Phe Ser Thr Glu Ser Ala Phe His Tyr Glu Ala Asp 
            260                 265                 270         


Gly Ala Asn Val Leu Ala Gly Ile Met Ser Arg Asn Asp Glu Arg Cys 
        275                 280                 285             


His Leu Asp Thr Thr Gly Thr Tyr Thr Gln Tyr Arg Thr Gln Asp Tyr 
    290                 295                 300                 


Pro Ser Val Pro Thr Leu Val Arg Leu Leu Ala Lys His Asn Ile Ile 
305                 310                 315                 320 


Pro Ile Phe Ala Val Thr Asn Tyr Ser Tyr Ser Tyr Tyr Glu Lys Leu 
                325                 330                 335     


His Thr Tyr Phe Pro Val Ser Ser Leu Gly Val Leu Gln Glu Asp Ser 
            340                 345                 350         


Ser Asn Ile Val Glu Leu Leu Glu Glu Ala Phe Asn Arg Ile Arg Ser 
        355                 360                 365             


Asn Leu Asp Ile Arg Ala Leu Asp Ser Pro Arg Gly Leu Arg Thr Glu 
    370                 375                 380                 


Val Thr Ser Lys Met Phe Gln Lys Thr Arg Thr Gly Ser Phe His Ile 
385                 390                 395                 400 


Arg Arg Gly Glu Val Gly Ile Tyr Gln Val Gln Leu Arg Ala Leu Glu 
                405                 410                 415     


His Val Asp Gly Thr His Val Cys Gln Leu Pro Glu Asp Gln Lys Gly 
            420                 425                 430         


Asn Ile His Leu Lys Pro Ser Phe Ser Asp Gly Leu Lys Met Asp Ala 
        435                 440                 445             


Gly Ile Ile Cys Asp Val Cys Thr Cys Glu Leu Gln Lys Glu Val Arg 
    450                 455                 460                 


Ser Ala Arg Cys Ser Phe Asn Gly Asp Phe Val Cys Gly Gln Cys Val 
465                 470                 475                 480 


Cys Ser Glu Gly Trp Ser Gly Gln Thr Cys Asn Cys Ser Thr Gly Ser 
                485                 490                 495     


Leu Ser Asp Ile Gln Pro Cys Leu Arg Glu Gly Glu Asp Lys Pro Cys 
            500                 505                 510         


Ser Gly Arg Gly Glu Cys Gln Cys Gly His Cys Val Cys Tyr Gly Glu 
        515                 520                 525             


Gly Arg Tyr Glu Gly Gln Phe Cys Glu Tyr Asp Asn Phe Gln Cys Pro 
    530                 535                 540                 


Arg Thr Ser Gly Phe Leu Cys Asn Asp Arg Gly Arg Cys Ser Met Gly 
545                 550                 555                 560 


Gln Cys Val Cys Glu Pro Gly Trp Thr Gly Pro Ser Cys Asp Cys Pro 
                565                 570                 575     


Leu Ser Asn Ala Thr Cys Ile Asp Ser Asn Gly Gly Ile Cys Asn Gly 
            580                 585                 590         


Arg Gly His Cys Glu Cys Gly Arg Cys His Cys His Gln Gln Ser Leu 
        595                 600                 605             


Tyr Thr Asp Thr Ile Cys Glu Ile Asn Tyr Ser Ala Ile His Pro Gly 
    610                 615                 620                 


Leu Cys Glu Asp Leu Arg Ser Cys Val Gln Cys Gln Ala Trp Gly Thr 
625                 630                 635                 640 


Gly Glu Lys Lys Gly Arg Thr Cys Glu Glu Cys Asn Phe Lys Val Lys 
                645                 650                 655     


Met Val Asp Glu Leu Lys Arg Ala Glu Glu Val Val Val Arg Cys Ser 
            660                 665                 670         


Phe Arg Asp Glu Asp Asp Asp Cys Thr Tyr Ser Tyr Thr Met Glu Gly 
        675                 680                 685             


Asp Gly Ala Pro Gly Pro Asn Ser Thr Val Leu Val His Lys Lys Lys 
    690                 695                 700                 


Asp Cys Pro Pro Gly Ser Phe Trp Trp Leu Ile Pro Leu Leu Leu Leu 
705                 710                 715                 720 


Leu Leu Pro Leu Leu Ala Leu Leu Leu Leu Leu Cys Trp Lys Tyr Cys 
                725                 730                 735     


Ala Cys Cys Lys Ala Cys Leu Ala Leu Leu Pro Cys Cys Asn Arg Gly 
            740                 745                 750         


His Met Val Gly Phe Lys Glu Asp His Tyr Met Leu Arg Glu Asn Leu 
        755                 760                 765             


Met Ala Ser Asp His Leu Asp Thr Pro Met Leu Arg Ser Gly Asn Leu 
    770                 775                 780                 


Lys Gly Arg Asp Val Val Arg Trp Lys Val Thr Asn Asn Met Gln Arg 
785                 790                 795                 800 


Pro Gly Phe Ala Thr His Ala Ala Ser Ile Asn Pro Thr Glu Leu Val 
                805                 810                 815     


Pro Tyr Gly Leu Ser Leu Arg Leu Ala Arg Leu Cys Thr Glu Asn Leu 
            820                 825                 830         


Leu Lys Pro Asp Thr Arg Glu Cys Ala Gln Leu Arg Gln Glu Val Glu 
        835                 840                 845             


Glu Asn Leu Asn Glu Val Tyr Arg Gln Ile Ser Gly Val His Lys Leu 
    850                 855                 860                 


Gln Gln Thr Lys Phe Arg Gln Gln Pro Asn Ala Gly Lys Lys Gln Asp 
865                 870                 875                 880 


His Thr Ile Val Asp Thr Val Leu Met Ala Pro Arg Ser Ala Lys Pro 
                885                 890                 895     


Ala Leu Leu Lys Leu Thr Glu Lys Gln Val Glu Gln Arg Ala Phe His 
            900                 905                 910         


Asp Leu Lys Val Ala Pro Gly Tyr Tyr Thr Leu Thr Ala Asp Gln Asp 
        915                 920                 925             


Ala Arg Gly Met Val Glu Phe Gln Glu Gly Val Glu Leu Val Asp Val 
    930                 935                 940                 


Arg Val Pro Leu Phe Ile Arg Pro Glu Asp Asp Asp Glu Lys Gln Leu 
945                 950                 955                 960 


Leu Val Glu Ala Ile Asp Val Pro Ala Gly Thr Ala Thr Leu Gly Arg 
                965                 970                 975     


Arg Leu Val Asn Ile Thr Ile Ile Lys Glu Gln Ala Arg Asp Val Val 
            980                 985                 990         


Ser Phe Glu Gln Pro Glu Phe Ser  Val Ser Arg Gly Asp  Gln Val Ala 
        995                 1000                 1005             


Arg Ile  Pro Val Ile Arg Arg  Val Leu Asp Gly Gly  Lys Ser Gln 
    1010                 1015                 1020             


Val Ser  Tyr Arg Thr Gln Asp  Gly Thr Ala Gln Gly  Asn Arg Asp 
    1025                 1030                 1035             


Tyr Ile  Pro Val Glu Gly Glu  Leu Leu Phe Gln Pro  Gly Glu Ala 
    1040                 1045                 1050             


Trp Lys  Glu Leu Gln Val Lys  Leu Leu Glu Leu Gln  Glu Val Asp 
    1055                 1060                 1065             


Ser Leu  Leu Arg Gly Arg Gln  Val Arg Arg Phe His  Val Gln Leu 
    1070                 1075                 1080             


Ser Asn  Pro Lys Phe Gly Ala  His Leu Gly Gln Pro  His Ser Thr 
    1085                 1090                 1095             


Thr Ile  Ile Ile Arg Asp Pro  Asp Glu Leu Asp Arg  Ser Phe Thr 
    1100                 1105                 1110             


Ser Gln  Met Leu Ser Ser Gln  Pro Pro Pro His Gly  Asp Leu Gly 
    1115                 1120                 1125             


Ala Pro  Gln Asn Pro Asn Ala  Lys Ala Ala Gly Ser  Arg Lys Ile 
    1130                 1135                 1140             


His Phe  Asn Trp Leu Pro Pro  Ser Gly Lys Pro Met  Gly Tyr Arg 
    1145                 1150                 1155             


Val Lys  Tyr Trp Ile Gln Gly  Asp Ser Glu Ser Glu  Ala His Leu 
    1160                 1165                 1170             


Leu Asp  Ser Lys Val Pro Ser  Val Glu Leu Thr Asn  Leu Tyr Pro 
    1175                 1180                 1185             


Tyr Cys  Asp Tyr Glu Met Lys  Val Cys Ala Tyr Gly  Ala Gln Gly 
    1190                 1195                 1200             


Glu Gly  Pro Tyr Ser Ser Leu  Val Ser Cys Arg Thr  His Gln Glu 
    1205                 1210                 1215             


Val Pro  Ser Glu Pro Gly Arg  Leu Ala Phe Asn Val  Val Ser Ser 
    1220                 1225                 1230             


Thr Val  Thr Gln Leu Ser Trp  Ala Glu Pro Ala Glu  Thr Asn Gly 
    1235                 1240                 1245             


Glu Ile  Thr Ala Tyr Glu Val  Cys Tyr Gly Leu Val  Asn Asp Asp 
    1250                 1255                 1260             


Asn Arg  Pro Ile Gly Pro Met  Lys Lys Val Leu Val  Asp Asn Pro 
    1265                 1270                 1275             


Lys Asn  Arg Met Leu Leu Ile  Glu Asn Leu Arg Glu  Ser Gln Pro 
    1280                 1285                 1290             


Tyr Arg  Tyr Thr Val Lys Ala  Arg Asn Gly Ala Gly  Trp Gly Pro 
    1295                 1300                 1305             


Glu Arg  Glu Ala Ile Ile Asn  Leu Ala Thr Gln Pro  Lys Arg Pro 
    1310                 1315                 1320             


Met Ser  Ile Pro Ile Ile Pro  Asp Ile Pro Ile Val  Asp Ala Gln 
    1325                 1330                 1335             


Ser Gly  Glu Asp Tyr Asp Ser  Phe Leu Met Tyr Ser  Asp Asp Val 
    1340                 1345                 1350             


Leu Arg  Ser Pro Ser Gly Ser  Gln Arg Pro Ser Val  Ser Asp Asp 
    1355                 1360                 1365             


Thr Glu  His Leu Val Asn Gly  Arg Met Asp Phe Ala  Phe Pro Gly 
    1370                 1375                 1380             


Ser Thr  Asn Ser Leu His Arg  Met Thr Thr Thr Ser  Ala Ala Ala 
    1385                 1390                 1395             


Tyr Gly  Thr His Leu Ser Pro  His Val Pro His Arg  Val Leu Ser 
    1400                 1405                 1410             


Thr Ser  Ser Thr Leu Thr Arg  Asp Tyr Asn Ser Leu  Thr Arg Ser 
    1415                 1420                 1425             


Glu His  Ser His Ser Thr Thr  Leu Pro Arg Asp Tyr  Ser Thr Leu 
    1430                 1435                 1440             


Thr Ser  Val Ser Ser His Asp  Ser Arg Leu Thr Ala  Gly Val Pro 
    1445                 1450                 1455             


Asp Thr  Pro Thr Arg Leu Val  Phe Ser Ala Leu Gly  Pro Thr Ser 
    1460                 1465                 1470             


Leu Arg  Val Ser Trp Gln Glu  Pro Arg Cys Glu Arg  Pro Leu Gln 
    1475                 1480                 1485             


Gly Tyr  Ser Val Glu Tyr Gln  Leu Leu Asn Gly Gly  Glu Leu His 
    1490                 1495                 1500             


Arg Leu  Asn Ile Pro Asn Pro  Ala Gln Thr Ser Val  Val Val Glu 
    1505                 1510                 1515             


Asp Leu  Leu Pro Asn His Ser  Tyr Val Phe Arg Val  Arg Ala Gln 
    1520                 1525                 1530             


Ser Gln  Glu Gly Trp Gly Arg  Glu Arg Glu Gly Val  Ile Thr Ile 
    1535                 1540                 1545             


Glu Ser  Gln Val His Pro Gln  Ser Pro Leu Cys Pro  Leu Pro Gly 
    1550                 1555                 1560             


Ser Ala  Phe Thr Leu Ser Thr  Pro Ser Ala Pro Gly  Pro Leu Val 
    1565                 1570                 1575             


Phe Thr  Ala Leu Ser Pro Asp  Ser Leu Gln Leu Ser  Trp Glu Arg 
    1580                 1585                 1590             


Pro Arg  Arg Pro Asn Gly Asp  Ile Val Gly Tyr Leu  Val Thr Cys 
    1595                 1600                 1605             


Glu Met  Ala Gln Gly Gly Gly  Pro Ala Thr Ala Phe  Arg Val Asp 
    1610                 1615                 1620             


Gly Asp  Ser Pro Glu Ser Arg  Leu Thr Val Pro Gly  Leu Ser Glu 
    1625                 1630                 1635             


Asn Val  Pro Tyr Lys Phe Lys  Val Gln Ala Arg Thr  Thr Glu Gly 
    1640                 1645                 1650             


Phe Gly  Pro Glu Arg Glu Gly  Ile Ile Thr Ile Glu  Ser Gln Asp 
    1655                 1660                 1665             


Gly Gly  Pro Phe Pro Gln Leu  Gly Ser Arg Ala Gly  Leu Phe Gln 
    1670                 1675                 1680             


His Pro  Leu Gln Ser Glu Tyr  Ser Ser Ile Thr Thr  Thr His Thr 
    1685                 1690                 1695             


Ser Ala  Thr Glu Pro Phe Leu  Val Asp Gly Leu Thr  Leu Gly Ala 
    1700                 1705                 1710             


Gln His  Leu Glu Ala Gly Gly  Ser Leu Thr Arg His  Val Thr Gln 
    1715                 1720                 1725             


Glu Phe  Val Ser Arg Thr Leu  Thr Thr Ser Gly Thr  Leu Ser Thr 
    1730                 1735                 1740             


His Met  Asp Gln Gln Phe Phe  Gln Thr 
    1745                 1750         


<210>  214
<211>  967
<212>  PRT
<213>  Homo sapiens

<400>  214

Met Ala Lys Gly Phe Tyr Ile Ser Lys Ser Leu Gly Ile Leu Gly Ile 
1               5                   10                  15      


Leu Leu Gly Val Ala Ala Val Cys Thr Ile Ile Ala Leu Ser Val Val 
            20                  25                  30          


Tyr Ser Gln Glu Lys Asn Lys Asn Ala Asn Ser Ser Pro Val Ala Ser 
        35                  40                  45              


Thr Thr Pro Ser Ala Ser Ala Thr Thr Asn Pro Ala Ser Ala Thr Thr 
    50                  55                  60                  


Leu Asp Gln Ser Lys Ala Trp Asn Arg Tyr Arg Leu Pro Asn Thr Leu 
65                  70                  75                  80  


Lys Pro Asp Ser Tyr Arg Val Thr Leu Arg Pro Tyr Leu Thr Pro Asn 
                85                  90                  95      


Asp Arg Gly Leu Tyr Val Phe Lys Gly Ser Ser Thr Val Arg Phe Thr 
            100                 105                 110         


Cys Lys Glu Ala Thr Asp Val Ile Ile Ile His Ser Lys Lys Leu Asn 
        115                 120                 125             


Tyr Thr Leu Ser Gln Gly His Arg Val Val Leu Arg Gly Val Gly Gly 
    130                 135                 140                 


Ser Gln Pro Pro Asp Ile Asp Lys Thr Glu Leu Val Glu Pro Thr Glu 
145                 150                 155                 160 


Tyr Leu Val Val His Leu Lys Gly Ser Leu Val Lys Asp Ser Gln Tyr 
                165                 170                 175     


Glu Met Asp Ser Glu Phe Glu Gly Glu Leu Ala Asp Asp Leu Ala Gly 
            180                 185                 190         


Phe Tyr Arg Ser Glu Tyr Met Glu Gly Asn Val Arg Lys Val Val Ala 
        195                 200                 205             


Thr Thr Gln Met Gln Ala Ala Asp Ala Arg Lys Ser Phe Pro Cys Phe 
    210                 215                 220                 


Asp Glu Pro Ala Met Lys Ala Glu Phe Asn Ile Thr Leu Ile His Pro 
225                 230                 235                 240 


Lys Asp Leu Thr Ala Leu Ser Asn Met Leu Pro Lys Gly Pro Ser Thr 
                245                 250                 255     


Pro Leu Pro Glu Asp Pro Asn Trp Asn Val Thr Glu Phe His Thr Thr 
            260                 265                 270         


Pro Lys Met Ser Thr Tyr Leu Leu Ala Phe Ile Val Ser Glu Phe Asp 
        275                 280                 285             


Tyr Val Glu Lys Gln Ala Ser Asn Gly Val Leu Ile Arg Ile Trp Ala 
    290                 295                 300                 


Arg Pro Ser Ala Ile Ala Ala Gly His Gly Asp Tyr Ala Leu Asn Val 
305                 310                 315                 320 


Thr Gly Pro Ile Leu Asn Phe Phe Ala Gly His Tyr Asp Thr Pro Tyr 
                325                 330                 335     


Pro Leu Pro Lys Ser Asp Gln Ile Gly Leu Pro Asp Phe Asn Ala Gly 
            340                 345                 350         


Ala Met Glu Asn Trp Gly Leu Val Thr Tyr Arg Glu Asn Ser Leu Leu 
        355                 360                 365             


Phe Asp Pro Leu Ser Ser Ser Ser Ser Asn Lys Glu Arg Val Val Thr 
    370                 375                 380                 


Val Ile Ala His Glu Leu Ala His Gln Trp Phe Gly Asn Leu Val Thr 
385                 390                 395                 400 


Ile Glu Trp Trp Asn Asp Leu Trp Leu Asn Glu Gly Phe Ala Ser Tyr 
                405                 410                 415     


Val Glu Tyr Leu Gly Ala Asp Tyr Ala Glu Pro Thr Trp Asn Leu Lys 
            420                 425                 430         


Asp Leu Met Val Leu Asn Asp Val Tyr Arg Val Met Ala Val Asp Ala 
        435                 440                 445             


Leu Ala Ser Ser His Pro Leu Ser Thr Pro Ala Ser Glu Ile Asn Thr 
    450                 455                 460                 


Pro Ala Gln Ile Ser Glu Leu Phe Asp Ala Ile Ser Tyr Ser Lys Gly 
465                 470                 475                 480 


Ala Ser Val Leu Arg Met Leu Ser Ser Phe Leu Ser Glu Asp Val Phe 
                485                 490                 495     


Lys Gln Gly Leu Ala Ser Tyr Leu His Thr Phe Ala Tyr Gln Asn Thr 
            500                 505                 510         


Ile Tyr Leu Asn Leu Trp Asp His Leu Gln Glu Ala Val Asn Asn Arg 
        515                 520                 525             


Ser Ile Gln Leu Pro Thr Thr Val Arg Asp Ile Met Asn Arg Trp Thr 
    530                 535                 540                 


Leu Gln Met Gly Phe Pro Val Ile Thr Val Asp Thr Ser Thr Gly Thr 
545                 550                 555                 560 


Leu Ser Gln Glu His Phe Leu Leu Asp Pro Asp Ser Asn Val Thr Arg 
                565                 570                 575     


Pro Ser Glu Phe Asn Tyr Val Trp Ile Val Pro Ile Thr Ser Ile Arg 
            580                 585                 590         


Asp Gly Arg Gln Gln Gln Asp Tyr Trp Leu Ile Asp Val Arg Ala Gln 
        595                 600                 605             


Asn Asp Leu Phe Ser Thr Ser Gly Asn Glu Trp Val Leu Leu Asn Leu 
    610                 615                 620                 


Asn Val Thr Gly Tyr Tyr Arg Val Asn Tyr Asp Glu Glu Asn Trp Arg 
625                 630                 635                 640 


Lys Ile Gln Thr Gln Leu Gln Arg Asp His Ser Ala Ile Pro Val Ile 
                645                 650                 655     


Asn Arg Ala Gln Ile Ile Asn Asp Ala Phe Asn Leu Ala Ser Ala His 
            660                 665                 670         


Lys Val Pro Val Thr Leu Ala Leu Asn Asn Thr Leu Phe Leu Ile Glu 
        675                 680                 685             


Glu Arg Gln Tyr Met Pro Trp Glu Ala Ala Leu Ser Ser Leu Ser Tyr 
    690                 695                 700                 


Phe Lys Leu Met Phe Asp Arg Ser Glu Val Tyr Gly Pro Met Lys Asn 
705                 710                 715                 720 


Tyr Leu Lys Lys Gln Val Thr Pro Leu Phe Ile His Phe Arg Asn Asn 
                725                 730                 735     


Thr Asn Asn Trp Arg Glu Ile Pro Glu Asn Leu Met Asp Gln Tyr Ser 
            740                 745                 750         


Glu Val Asn Ala Ile Ser Thr Ala Cys Ser Asn Gly Val Pro Glu Cys 
        755                 760                 765             


Glu Glu Met Val Ser Gly Leu Phe Lys Gln Trp Met Glu Asn Pro Asn 
    770                 775                 780                 


Asn Asn Pro Ile His Pro Asn Leu Arg Ser Thr Val Tyr Cys Asn Ala 
785                 790                 795                 800 


Ile Ala Gln Gly Gly Glu Glu Glu Trp Asp Phe Ala Trp Glu Gln Phe 
                805                 810                 815     


Arg Asn Ala Thr Leu Val Asn Glu Ala Asp Lys Leu Arg Ala Ala Leu 
            820                 825                 830         


Ala Cys Ser Lys Glu Leu Trp Ile Leu Asn Arg Tyr Leu Ser Tyr Thr 
        835                 840                 845             


Leu Asn Pro Asp Leu Ile Arg Lys Gln Asp Ala Thr Ser Thr Ile Ile 
    850                 855                 860                 


Ser Ile Thr Asn Asn Val Ile Gly Gln Gly Leu Val Trp Asp Phe Val 
865                 870                 875                 880 


Gln Ser Asn Trp Lys Lys Leu Phe Asn Asp Tyr Gly Gly Gly Ser Phe 
                885                 890                 895     


Ser Phe Ser Asn Leu Ile Gln Ala Val Thr Arg Arg Phe Ser Thr Glu 
            900                 905                 910         


Tyr Glu Leu Gln Gln Leu Glu Gln Phe Lys Lys Asp Asn Glu Glu Thr 
        915                 920                 925             


Gly Phe Gly Ser Gly Thr Arg Ala Leu Glu Gln Ala Leu Glu Lys Thr 
    930                 935                 940                 


Lys Ala Asn Ile Lys Trp Val Lys Glu Asn Lys Glu Val Val Leu Gln 
945                 950                 955                 960 


Trp Phe Thr Glu Asn Ser Lys 
                965         


<210>  215
<211>  351
<212>  PRT
<213>  Homo sapiens

<400>  215

Met Ser Phe Pro Cys Lys Phe Val Ala Ser Phe Leu Leu Ile Phe Asn 
1               5                   10                  15      


Val Ser Ser Lys Gly Ala Val Ser Lys Glu Ile Thr Asn Ala Leu Glu 
            20                  25                  30          


Thr Trp Gly Ala Leu Gly Gln Asp Ile Asn Leu Asp Ile Pro Ser Phe 
        35                  40                  45              


Gln Met Ser Asp Asp Ile Asp Asp Ile Lys Trp Glu Lys Thr Ser Asp 
    50                  55                  60                  


Lys Lys Lys Ile Ala Gln Phe Arg Lys Glu Lys Glu Thr Phe Lys Glu 
65                  70                  75                  80  


Lys Asp Thr Tyr Lys Leu Phe Lys Asn Gly Thr Leu Lys Ile Lys His 
                85                  90                  95      


Leu Lys Thr Asp Asp Gln Asp Ile Tyr Lys Val Ser Ile Tyr Asp Thr 
            100                 105                 110         


Lys Gly Lys Asn Val Leu Glu Lys Ile Phe Asp Leu Lys Ile Gln Glu 
        115                 120                 125             


Arg Val Ser Lys Pro Lys Ile Ser Trp Thr Cys Ile Asn Thr Thr Leu 
    130                 135                 140                 


Thr Cys Glu Val Met Asn Gly Thr Asp Pro Glu Leu Asn Leu Tyr Gln 
145                 150                 155                 160 


Asp Gly Lys His Leu Lys Leu Ser Gln Arg Val Ile Thr His Lys Trp 
                165                 170                 175     


Thr Thr Ser Leu Ser Ala Lys Phe Lys Cys Thr Ala Gly Asn Lys Val 
            180                 185                 190         


Ser Lys Glu Ser Ser Val Glu Pro Val Ser Cys Pro Glu Lys Gly Leu 
        195                 200                 205             


Asp Ile Tyr Leu Ile Ile Gly Ile Cys Gly Gly Gly Ser Leu Leu Met 
    210                 215                 220                 


Val Phe Val Ala Leu Leu Val Phe Tyr Ile Thr Lys Arg Lys Lys Gln 
225                 230                 235                 240 


Arg Ser Arg Arg Asn Asp Glu Glu Leu Glu Thr Arg Ala His Arg Val 
                245                 250                 255     


Ala Thr Glu Glu Arg Gly Arg Lys Pro His Gln Ile Pro Ala Ser Thr 
            260                 265                 270         


Pro Gln Asn Pro Ala Thr Ser Gln His Pro Pro Pro Pro Pro Gly His 
        275                 280                 285             


Arg Ser Gln Ala Pro Ser His Arg Pro Pro Pro Pro Gly His Arg Val 
    290                 295                 300                 


Gln His Gln Pro Gln Lys Arg Pro Pro Ala Pro Ser Gly Thr Gln Val 
305                 310                 315                 320 


His Gln Gln Lys Gly Pro Pro Leu Pro Arg Pro Arg Val Gln Pro Lys 
                325                 330                 335     


Pro Pro His Gly Ala Ala Glu Asn Ser Leu Ser Pro Ser Ser Asn 
            340                 345                 350     


<210>  216
<211>  207
<212>  PRT
<213>  Homo sapiens

<400>  216

Met Gln Ser Gly Thr His Trp Arg Val Leu Gly Leu Cys Leu Leu Ser 
1               5                   10                  15      


Val Gly Val Trp Gly Gln Asp Gly Asn Glu Glu Met Gly Gly Ile Thr 
            20                  25                  30          


Gln Thr Pro Tyr Lys Val Ser Ile Ser Gly Thr Thr Val Ile Leu Thr 
        35                  40                  45              


Cys Pro Gln Tyr Pro Gly Ser Glu Ile Leu Trp Gln His Asn Asp Lys 
    50                  55                  60                  


Asn Ile Gly Gly Asp Glu Asp Asp Lys Asn Ile Gly Ser Asp Glu Asp 
65                  70                  75                  80  


His Leu Ser Leu Lys Glu Phe Ser Glu Leu Glu Gln Ser Gly Tyr Tyr 
                85                  90                  95      


Val Cys Tyr Pro Arg Gly Ser Lys Pro Glu Asp Ala Asn Phe Tyr Leu 
            100                 105                 110         


Tyr Leu Arg Ala Arg Val Cys Glu Asn Cys Met Glu Met Asp Val Met 
        115                 120                 125             


Ser Val Ala Thr Ile Val Ile Val Asp Ile Cys Ile Thr Gly Gly Leu 
    130                 135                 140                 


Leu Leu Leu Val Tyr Tyr Trp Ser Lys Asn Arg Lys Ala Lys Ala Lys 
145                 150                 155                 160 


Pro Val Thr Arg Gly Ala Gly Ala Gly Gly Arg Gln Arg Gly Gln Asn 
                165                 170                 175     


Lys Glu Arg Pro Pro Pro Val Pro Asn Pro Asp Tyr Glu Pro Ile Arg 
            180                 185                 190         


Lys Gly Gln Arg Asp Leu Tyr Ser Gly Leu Asn Gln Arg Arg Ile 
        195                 200                 205         


<210>  217
<211>  164
<212>  PRT
<213>  Homo sapiens

<400>  217

Met Lys Trp Lys Ala Leu Phe Thr Ala Ala Ile Leu Gln Ala Gln Leu 
1               5                   10                  15      


Pro Ile Thr Glu Ala Gln Ser Phe Gly Leu Leu Asp Pro Lys Leu Cys 
            20                  25                  30          


Tyr Leu Leu Asp Gly Ile Leu Phe Ile Tyr Gly Val Ile Leu Thr Ala 
        35                  40                  45              


Leu Phe Leu Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr 
    50                  55                  60                  


Gln Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg 
65                  70                  75                  80  


Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met 
                85                  90                  95      


Gly Gly Lys Pro Gln Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn 
            100                 105                 110         


Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met 
        115                 120                 125             


Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly 
    130                 135                 140                 


Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala 
145                 150                 155                 160 


Leu Pro Pro Arg 
                


<210>  218
<211>  769
<212>  PRT
<213>  Homo sapiens

<400>  218

Met Leu Gly Leu Arg Pro Pro Leu Leu Ala Leu Val Gly Leu Leu Ser 
1               5                   10                  15      


Leu Gly Cys Val Leu Ser Gln Glu Cys Thr Lys Phe Lys Val Ser Ser 
            20                  25                  30          


Cys Arg Glu Cys Ile Glu Ser Gly Pro Gly Cys Thr Trp Cys Gln Lys 
        35                  40                  45              


Leu Asn Phe Thr Gly Pro Gly Asp Pro Asp Ser Ile Arg Cys Asp Thr 
    50                  55                  60                  


Arg Pro Gln Leu Leu Met Arg Gly Cys Ala Ala Asp Asp Ile Met Asp 
65                  70                  75                  80  


Pro Thr Ser Leu Ala Glu Thr Gln Glu Asp His Asn Gly Gly Gln Lys 
                85                  90                  95      


Gln Leu Ser Pro Gln Lys Val Thr Leu Tyr Leu Arg Pro Gly Gln Ala 
            100                 105                 110         


Ala Ala Phe Asn Val Thr Phe Arg Arg Ala Lys Gly Tyr Pro Ile Asp 
        115                 120                 125             


Leu Tyr Tyr Leu Met Asp Leu Ser Tyr Ser Met Leu Asp Asp Leu Arg 
    130                 135                 140                 


Asn Val Lys Lys Leu Gly Gly Asp Leu Leu Arg Ala Leu Asn Glu Ile 
145                 150                 155                 160 


Thr Glu Ser Gly Arg Ile Gly Phe Gly Ser Phe Val Asp Lys Thr Val 
                165                 170                 175     


Leu Pro Phe Val Asn Thr His Pro Asp Lys Leu Arg Asn Pro Cys Pro 
            180                 185                 190         


Asn Lys Glu Lys Glu Cys Gln Pro Pro Phe Ala Phe Arg His Val Leu 
        195                 200                 205             


Lys Leu Thr Asn Asn Ser Asn Gln Phe Gln Thr Glu Val Gly Lys Gln 
    210                 215                 220                 


Leu Ile Ser Gly Asn Leu Asp Ala Pro Glu Gly Gly Leu Asp Ala Met 
225                 230                 235                 240 


Met Gln Val Ala Ala Cys Pro Glu Glu Ile Gly Trp Arg Asn Val Thr 
                245                 250                 255     


Arg Leu Leu Val Phe Ala Thr Asp Asp Gly Phe His Phe Ala Gly Asp 
            260                 265                 270         


Gly Lys Leu Gly Ala Ile Leu Thr Pro Asn Asp Gly Arg Cys His Leu 
        275                 280                 285             


Glu Asp Asn Leu Tyr Lys Arg Ser Asn Glu Phe Asp Tyr Pro Ser Val 
    290                 295                 300                 


Gly Gln Leu Ala His Lys Leu Ala Glu Asn Asn Ile Gln Pro Ile Phe 
305                 310                 315                 320 


Ala Val Thr Ser Arg Met Val Lys Thr Tyr Glu Lys Leu Thr Glu Ile 
                325                 330                 335     


Ile Pro Lys Ser Ala Val Gly Glu Leu Ser Glu Asp Ser Ser Asn Val 
            340                 345                 350         


Val His Leu Ile Lys Asn Ala Tyr Asn Lys Leu Ser Ser Arg Val Phe 
        355                 360                 365             


Leu Asp His Asn Ala Leu Pro Asp Thr Leu Lys Val Thr Tyr Asp Ser 
    370                 375                 380                 


Phe Cys Ser Asn Gly Val Thr His Arg Asn Gln Pro Arg Gly Asp Cys 
385                 390                 395                 400 


Asp Gly Val Gln Ile Asn Val Pro Ile Thr Phe Gln Val Lys Val Thr 
                405                 410                 415     


Ala Thr Glu Cys Ile Gln Glu Gln Ser Phe Val Ile Arg Ala Leu Gly 
            420                 425                 430         


Phe Thr Asp Ile Val Thr Val Gln Val Leu Pro Gln Cys Glu Cys Arg 
        435                 440                 445             


Cys Arg Asp Gln Ser Arg Asp Arg Ser Leu Cys His Gly Lys Gly Phe 
    450                 455                 460                 


Leu Glu Cys Gly Ile Cys Arg Cys Asp Thr Gly Tyr Ile Gly Lys Asn 
465                 470                 475                 480 


Cys Glu Cys Gln Thr Gln Gly Arg Ser Ser Gln Glu Leu Glu Gly Ser 
                485                 490                 495     


Cys Arg Lys Asp Asn Asn Ser Ile Ile Cys Ser Gly Leu Gly Asp Cys 
            500                 505                 510         


Val Cys Gly Gln Cys Leu Cys His Thr Ser Asp Val Pro Gly Lys Leu 
        515                 520                 525             


Ile Tyr Gly Gln Tyr Cys Glu Cys Asp Thr Ile Asn Cys Glu Arg Tyr 
    530                 535                 540                 


Asn Gly Gln Val Cys Gly Gly Pro Gly Arg Gly Leu Cys Phe Cys Gly 
545                 550                 555                 560 


Lys Cys Arg Cys His Pro Gly Phe Glu Gly Ser Ala Cys Gln Cys Glu 
                565                 570                 575     


Arg Thr Thr Glu Gly Cys Leu Asn Pro Arg Arg Val Glu Cys Ser Gly 
            580                 585                 590         


Arg Gly Arg Cys Arg Cys Asn Val Cys Glu Cys His Ser Gly Tyr Gln 
        595                 600                 605             


Leu Pro Leu Cys Gln Glu Cys Pro Gly Cys Pro Ser Pro Cys Gly Lys 
    610                 615                 620                 


Tyr Ile Ser Cys Ala Glu Cys Leu Lys Phe Glu Lys Gly Pro Phe Gly 
625                 630                 635                 640 


Lys Asn Cys Ser Ala Ala Cys Pro Gly Leu Gln Leu Ser Asn Asn Pro 
                645                 650                 655     


Val Lys Gly Arg Thr Cys Lys Glu Arg Asp Ser Glu Gly Cys Trp Val 
            660                 665                 670         


Ala Tyr Thr Leu Glu Gln Gln Asp Gly Met Asp Arg Tyr Leu Ile Tyr 
        675                 680                 685             


Val Asp Glu Ser Arg Glu Cys Val Ala Gly Pro Asn Ile Ala Ala Ile 
    690                 695                 700                 


Val Gly Gly Thr Val Ala Gly Ile Val Leu Ile Gly Ile Leu Leu Leu 
705                 710                 715                 720 


Val Ile Trp Lys Ala Leu Ile His Leu Ser Asp Leu Arg Glu Tyr Arg 
                725                 730                 735     


Arg Phe Glu Lys Glu Lys Leu Lys Ser Gln Trp Asn Asn Asp Asn Pro 
            740                 745                 750         


Leu Phe Lys Ser Ala Thr Thr Thr Val Met Asn Pro Lys Phe Ala Glu 
        755                 760                 765             


Ser 
    


<210>  219
<211>  556
<212>  PRT
<213>  Homo sapiens

<400>  219

Met Pro Pro Pro Arg Leu Leu Phe Phe Leu Leu Phe Leu Thr Pro Met 
1               5                   10                  15      


Glu Val Arg Pro Glu Glu Pro Leu Val Val Lys Val Glu Glu Gly Asp 
            20                  25                  30          


Asn Ala Val Leu Gln Cys Leu Lys Gly Thr Ser Asp Gly Pro Thr Gln 
        35                  40                  45              


Gln Leu Thr Trp Ser Arg Glu Ser Pro Leu Lys Pro Phe Leu Lys Leu 
    50                  55                  60                  


Ser Leu Gly Leu Pro Gly Leu Gly Ile His Met Arg Pro Leu Ala Ile 
65                  70                  75                  80  


Trp Leu Phe Ile Phe Asn Val Ser Gln Gln Met Gly Gly Phe Tyr Leu 
                85                  90                  95      


Cys Gln Pro Gly Pro Pro Ser Glu Lys Ala Trp Gln Pro Gly Trp Thr 
            100                 105                 110         


Val Asn Val Glu Gly Ser Gly Glu Leu Phe Arg Trp Asn Val Ser Asp 
        115                 120                 125             


Leu Gly Gly Leu Gly Cys Gly Leu Lys Asn Arg Ser Ser Glu Gly Pro 
    130                 135                 140                 


Ser Ser Pro Ser Gly Lys Leu Met Ser Pro Lys Leu Tyr Val Trp Ala 
145                 150                 155                 160 


Lys Asp Arg Pro Glu Ile Trp Glu Gly Glu Pro Pro Cys Leu Pro Pro 
                165                 170                 175     


Arg Asp Ser Leu Asn Gln Ser Leu Ser Gln Asp Leu Thr Met Ala Pro 
            180                 185                 190         


Gly Ser Thr Leu Trp Leu Ser Cys Gly Val Pro Pro Asp Ser Val Ser 
        195                 200                 205             


Arg Gly Pro Leu Ser Trp Thr His Val His Pro Lys Gly Pro Lys Ser 
    210                 215                 220                 


Leu Leu Ser Leu Glu Leu Lys Asp Asp Arg Pro Ala Arg Asp Met Trp 
225                 230                 235                 240 


Val Met Glu Thr Gly Leu Leu Leu Pro Arg Ala Thr Ala Gln Asp Ala 
                245                 250                 255     


Gly Lys Tyr Tyr Cys His Arg Gly Asn Leu Thr Met Ser Phe His Leu 
            260                 265                 270         


Glu Ile Thr Ala Arg Pro Val Leu Trp His Trp Leu Leu Arg Thr Gly 
        275                 280                 285             


Gly Trp Lys Val Ser Ala Val Thr Leu Ala Tyr Leu Ile Phe Cys Leu 
    290                 295                 300                 


Cys Ser Leu Val Gly Ile Leu His Leu Gln Arg Ala Leu Val Leu Arg 
305                 310                 315                 320 


Arg Lys Arg Lys Arg Met Thr Asp Pro Thr Arg Arg Phe Phe Lys Val 
                325                 330                 335     


Thr Pro Pro Pro Gly Ser Gly Pro Gln Asn Gln Tyr Gly Asn Val Leu 
            340                 345                 350         


Ser Leu Pro Thr Pro Thr Ser Gly Leu Gly Arg Ala Gln Arg Trp Ala 
        355                 360                 365             


Ala Gly Leu Gly Gly Thr Ala Pro Ser Tyr Gly Asn Pro Ser Ser Asp 
    370                 375                 380                 


Val Gln Ala Asp Gly Ala Leu Gly Ser Arg Ser Pro Pro Gly Val Gly 
385                 390                 395                 400 


Pro Glu Glu Glu Glu Gly Glu Gly Tyr Glu Glu Pro Asp Ser Glu Glu 
                405                 410                 415     


Asp Ser Glu Phe Tyr Glu Asn Asp Ser Asn Leu Gly Gln Asp Gln Leu 
            420                 425                 430         


Ser Gln Asp Gly Ser Gly Tyr Glu Asn Pro Glu Asp Glu Pro Leu Gly 
        435                 440                 445             


Pro Glu Asp Glu Asp Ser Phe Ser Asn Ala Glu Ser Tyr Glu Asn Glu 
    450                 455                 460                 


Asp Glu Glu Leu Thr Gln Pro Val Ala Arg Thr Met Asp Phe Leu Ser 
465                 470                 475                 480 


Pro His Gly Ser Ala Trp Asp Pro Ser Arg Glu Ala Thr Ser Leu Gly 
                485                 490                 495     


Ser Gln Ser Tyr Glu Asp Met Arg Gly Ile Leu Tyr Ala Ala Pro Gln 
            500                 505                 510         


Leu Arg Ser Ile Arg Gly Gln Pro Gly Pro Asn His Glu Glu Asp Ala 
        515                 520                 525             


Asp Ser Tyr Glu Asn Met Asp Asn Pro Asp Gly Pro Asp Pro Ala Trp 
    530                 535                 540                 


Gly Gly Gly Gly Arg Met Gly Thr Trp Ser Thr Arg 
545                 550                 555     


<210>  220
<211>  483
<212>  PRT
<213>  Homo sapiens

<400>  220

Met Phe Cys Ser Thr Ser Ala Val Asn Ser Cys Ala Arg Cys Phe Phe 
1               5                   10                  15      


His Ser Val Cys Pro Ala Gly Met Ile Val Lys Phe Pro Gly Thr Ala 
            20                  25                  30          


Gln Lys Asn Thr Val Cys Glu Pro Ala Ser Pro Gly Val Ser Pro Ala 
        35                  40                  45              


Cys Ala Ser Pro Glu Asn Cys Lys Glu Pro Ser Ser Gly Thr Ile Pro 
    50                  55                  60                  


Gln Ala Lys Pro Thr Pro Val Ser Pro Ala Thr Ser Ser Ala Ser Thr 
65                  70                  75                  80  


Met Pro Val Arg Gly Gly Thr Arg Leu Ala Gln Glu Ala Ala Ser Lys 
                85                  90                  95      


Leu Thr Arg Ala Pro Asp Ser Pro Ser Ser Val Gly Arg Pro Ser Ser 
            100                 105                 110         


Asp Pro Gly Leu Ser Pro Thr Gln Pro Cys Pro Glu Gly Ser Gly Asp 
        115                 120                 125             


Cys Arg Lys Gln Cys Glu Pro Asp Tyr Tyr Leu Asp Glu Ala Gly Arg 
    130                 135                 140                 


Cys Thr Ala Cys Val Ser Cys Ser Arg Asp Asp Leu Val Glu Lys Thr 
145                 150                 155                 160 


Pro Cys Ala Trp Asn Ser Ser Arg Thr Cys Glu Cys Arg Pro Gly Met 
                165                 170                 175     


Ile Cys Ala Thr Ser Ala Thr Asn Ser Cys Ala Arg Cys Val Pro Tyr 
            180                 185                 190         


Pro Ile Cys Ala Ala Glu Thr Val Thr Lys Pro Gln Asp Met Ala Glu 
        195                 200                 205             


Lys Asp Thr Thr Phe Glu Ala Pro Pro Leu Gly Thr Gln Pro Asp Cys 
    210                 215                 220                 


Asn Pro Thr Pro Glu Asn Gly Glu Ala Pro Ala Ser Thr Ser Pro Thr 
225                 230                 235                 240 


Gln Ser Leu Leu Val Asp Ser Gln Ala Ser Lys Thr Leu Pro Ile Pro 
                245                 250                 255     


Thr Ser Ala Pro Val Ala Leu Ser Ser Thr Gly Lys Pro Val Leu Asp 
            260                 265                 270         


Ala Gly Pro Val Leu Phe Trp Val Ile Leu Val Leu Val Val Val Val 
        275                 280                 285             


Gly Ser Ser Ala Phe Leu Leu Cys His Arg Arg Ala Cys Arg Lys Arg 
    290                 295                 300                 


Ile Arg Gln Lys Leu His Leu Cys Tyr Pro Val Gln Thr Ser Gln Pro 
305                 310                 315                 320 


Lys Leu Glu Leu Val Asp Ser Arg Pro Arg Arg Ser Ser Thr Leu Arg 
                325                 330                 335     


Ser Gly Ala Ser Val Thr Glu Pro Val Ala Glu Glu Arg Gly Leu Met 
            340                 345                 350         


Ser Gln Pro Leu Met Glu Thr Cys His Ser Val Gly Ala Ala Tyr Leu 
        355                 360                 365             


Glu Ser Leu Pro Leu Gln Asp Ala Ser Pro Ala Gly Gly Pro Ser Ser 
    370                 375                 380                 


Pro Arg Asp Leu Pro Glu Pro Arg Val Ser Thr Glu His Thr Asn Asn 
385                 390                 395                 400 


Lys Ile Glu Lys Ile Tyr Ile Met Lys Ala Asp Thr Val Ile Val Gly 
                405                 410                 415     


Thr Val Lys Ala Glu Leu Pro Glu Gly Arg Gly Leu Ala Gly Pro Ala 
            420                 425                 430         


Glu Pro Glu Leu Glu Glu Glu Leu Glu Ala Asp His Thr Pro His Tyr 
        435                 440                 445             


Pro Glu Gln Glu Thr Glu Pro Pro Leu Gly Ser Cys Ser Asp Val Met 
    450                 455                 460                 


Leu Ser Val Glu Glu Glu Gly Lys Glu Asp Pro Leu Pro Thr Ala Ala 
465                 470                 475                 480 


Ser Gly Lys 
            


<210>  221
<211>  328
<212>  PRT
<213>  Homo sapiens

<400>  221

Met Leu Val Arg Arg Gly Ala Arg Ala Gly Pro Arg Met Pro Arg Gly 
1               5                   10                  15      


Trp Thr Ala Leu Cys Leu Leu Ser Leu Leu Pro Ser Gly Phe Met Ser 
            20                  25                  30          


Leu Asp Asn Asn Gly Thr Ala Thr Pro Glu Leu Pro Thr Gln Gly Thr 
        35                  40                  45              


Phe Ser Asn Val Ser Thr Asn Val Ser Tyr Gln Glu Thr Thr Thr Pro 
    50                  55                  60                  


Ser Thr Leu Gly Ser Thr Ser Leu His Pro Val Ser Gln His Gly Asn 
65                  70                  75                  80  


Glu Ala Thr Thr Asn Ile Thr Glu Thr Thr Val Lys Phe Thr Ser Thr 
                85                  90                  95      


Ser Val Ile Thr Ser Val Tyr Gly Asn Thr Asn Ser Ser Val Gln Ser 
            100                 105                 110         


Gln Thr Ser Val Ile Ser Thr Val Phe Thr Thr Pro Ala Asn Val Ser 
        115                 120                 125             


Thr Pro Glu Thr Thr Leu Lys Pro Ser Leu Ser Pro Gly Asn Val Ser 
    130                 135                 140                 


Asp Leu Ser Thr Thr Ser Thr Ser Leu Ala Thr Ser Pro Thr Lys Pro 
145                 150                 155                 160 


Tyr Thr Ser Ser Ser Pro Ile Leu Ser Asp Ile Lys Ala Glu Ile Lys 
                165                 170                 175     


Cys Ser Gly Ile Arg Glu Val Lys Leu Thr Gln Gly Ile Cys Leu Glu 
            180                 185                 190         


Gln Asn Lys Thr Ser Ser Cys Ala Glu Phe Lys Lys Asp Arg Gly Glu 
        195                 200                 205             


Gly Leu Ala Arg Val Leu Cys Gly Glu Glu Gln Ala Asp Ala Asp Ala 
    210                 215                 220                 


Gly Ala Gln Val Cys Ser Leu Leu Leu Ala Gln Ser Glu Val Arg Pro 
225                 230                 235                 240 


Gln Cys Leu Leu Leu Val Leu Ala Asn Arg Thr Glu Ile Ser Ser Lys 
                245                 250                 255     


Leu Gln Leu Met Lys Lys His Gln Ser Asp Leu Lys Lys Leu Gly Ile 
            260                 265                 270         


Leu Asp Phe Thr Glu Gln Asp Val Ala Ser His Gln Ser Tyr Ser Gln 
        275                 280                 285             


Lys Thr Leu Ile Ala Leu Val Thr Ser Gly Ala Leu Leu Ala Val Leu 
    290                 295                 300                 


Gly Ile Thr Gly Tyr Phe Leu Met Asn Arg Arg Ser Trp Ser Pro Thr 
305                 310                 315                 320 


Gly Glu Arg Leu Glu Leu Glu Pro 
                325             


<210>  222
<211>  472
<212>  PRT
<213>  Homo sapiens

<400>  222

Met Gly Cys Asp Arg Asn Cys Gly Leu Ile Ala Gly Ala Val Ile Gly 
1               5                   10                  15      


Ala Val Leu Ala Val Phe Gly Gly Ile Leu Met Pro Val Gly Asp Leu 
            20                  25                  30          


Leu Ile Gln Lys Thr Ile Lys Lys Gln Val Val Leu Glu Glu Gly Thr 
        35                  40                  45              


Ile Ala Phe Lys Asn Trp Val Lys Thr Gly Thr Glu Val Tyr Arg Gln 
    50                  55                  60                  


Phe Trp Ile Phe Asp Val Gln Asn Pro Gln Glu Val Met Met Asn Ser 
65                  70                  75                  80  


Ser Asn Ile Gln Val Lys Gln Arg Gly Pro Tyr Thr Tyr Arg Val Arg 
                85                  90                  95      


Phe Leu Ala Lys Glu Asn Val Thr Gln Asp Ala Glu Asp Asn Thr Val 
            100                 105                 110         


Ser Phe Leu Gln Pro Asn Gly Ala Ile Phe Glu Pro Ser Leu Ser Val 
        115                 120                 125             


Gly Thr Glu Ala Asp Asn Phe Thr Val Leu Asn Leu Ala Val Ala Ala 
    130                 135                 140                 


Ala Ser His Ile Tyr Gln Asn Gln Phe Val Gln Met Ile Leu Asn Ser 
145                 150                 155                 160 


Leu Ile Asn Lys Ser Lys Ser Ser Met Phe Gln Val Arg Thr Leu Arg 
                165                 170                 175     


Glu Leu Leu Trp Gly Tyr Arg Asp Pro Phe Leu Ser Leu Val Pro Tyr 
            180                 185                 190         


Pro Val Thr Thr Thr Val Gly Leu Phe Tyr Pro Tyr Asn Asn Thr Ala 
        195                 200                 205             


Asp Gly Val Tyr Lys Val Phe Asn Gly Lys Asp Asn Ile Ser Lys Val 
    210                 215                 220                 


Ala Ile Ile Asp Thr Tyr Lys Gly Lys Arg Asn Leu Ser Tyr Trp Glu 
225                 230                 235                 240 


Ser His Cys Asp Met Ile Asn Gly Thr Asp Ala Ala Ser Phe Pro Pro 
                245                 250                 255     


Phe Val Glu Lys Ser Gln Val Leu Gln Phe Phe Ser Ser Asp Ile Cys 
            260                 265                 270         


Arg Ser Ile Tyr Ala Val Phe Glu Ser Asp Val Asn Leu Lys Gly Ile 
        275                 280                 285             


Pro Val Tyr Arg Phe Val Leu Pro Ser Lys Ala Phe Ala Ser Pro Val 
    290                 295                 300                 


Glu Asn Pro Asp Asn Tyr Cys Phe Cys Thr Glu Lys Ile Ile Ser Lys 
305                 310                 315                 320 


Asn Cys Thr Ser Tyr Gly Val Leu Asp Ile Ser Lys Cys Lys Glu Gly 
                325                 330                 335     


Arg Pro Val Tyr Ile Ser Leu Pro His Phe Leu Tyr Ala Ser Pro Asp 
            340                 345                 350         


Val Ser Glu Pro Ile Asp Gly Leu Asn Pro Asn Glu Glu Glu His Arg 
        355                 360                 365             


Thr Tyr Leu Asp Ile Glu Pro Ile Thr Gly Phe Thr Leu Gln Phe Ala 
    370                 375                 380                 


Lys Arg Leu Gln Val Asn Leu Leu Val Lys Pro Ser Glu Lys Ile Gln 
385                 390                 395                 400 


Val Leu Lys Asn Leu Lys Arg Asn Tyr Ile Val Pro Ile Leu Trp Leu 
                405                 410                 415     


Asn Glu Thr Gly Thr Ile Gly Asp Glu Lys Ala Asn Met Phe Arg Ser 
            420                 425                 430         


Gln Val Thr Gly Lys Ile Asn Leu Leu Gly Leu Ile Glu Met Ile Leu 
        435                 440                 445             


Leu Ser Val Gly Val Val Met Phe Val Ala Phe Met Ile Ser Tyr Cys 
    450                 455                 460                 


Ala Cys Arg Ser Lys Thr Ile Lys 
465                 470         


<210>  223
<211>  237
<212>  PRT
<213>  Homo sapiens

<400>  223

Met Val Arg Leu Pro Leu Gln Cys Val Leu Trp Gly Cys Leu Leu Thr 
1               5                   10                  15      


Ala Val His Pro Glu Pro Pro Thr Ala Cys Arg Glu Lys Gln Tyr Leu 
            20                  25                  30          


Ile Asn Ser Gln Cys Cys Ser Leu Cys Gln Pro Gly Gln Lys Leu Val 
        35                  40                  45              


Ser Asp Cys Thr Glu Phe Thr Glu Thr Glu Cys Leu Pro Cys Gly Glu 
    50                  55                  60                  


Ser Glu Phe Leu Asp Thr Trp Asn Arg Glu Thr His Cys His Gln His 
65                  70                  75                  80  


Lys Tyr Cys Asp Pro Asn Leu Gly Leu Arg Val Gln Gln Lys Gly Thr 
                85                  90                  95      


Ser Glu Thr Asp Thr Ile Cys Thr Cys Glu Glu Gly Trp His Cys Thr 
            100                 105                 110         


Ser Glu Ala Cys Glu Ser Cys Val Leu His Arg Ser Cys Ser Pro Gly 
        115                 120                 125             


Phe Gly Val Lys Gln Ile Ala Thr Gly Val Ser Asp Thr Ile Cys Glu 
    130                 135                 140                 


Pro Cys Pro Val Gly Phe Phe Ser Asn Val Ser Ser Ala Phe Glu Lys 
145                 150                 155                 160 


Cys His Pro Trp Thr Ser Cys Glu Thr Lys Asp Leu Val Val Gln Gln 
                165                 170                 175     


Ala Gly Thr Asn Lys Thr Asp Val Val Cys Gly Glu Ser Trp Thr Met 
            180                 185                 190         


Gly Pro Gly Glu Ser Leu Gly Arg Ser Pro Gly Ser Ala Glu Ser Pro 
        195                 200                 205             


Gly Gly Asp Pro His His Leu Arg Asp Pro Val Cys His Pro Leu Gly 
    210                 215                 220                 


Ala Gly Leu Tyr Gln Lys Gly Gly Gln Glu Ala Asn Gln 
225                 230                 235         


<210>  224
<211>  261
<212>  PRT
<213>  Homo sapiens

<400>  224

Met Ile Glu Thr Tyr Asn Gln Thr Ser Pro Arg Ser Ala Ala Thr Gly 
1               5                   10                  15      


Leu Pro Ile Ser Met Lys Ile Phe Met Tyr Leu Leu Thr Val Phe Leu 
            20                  25                  30          


Ile Thr Gln Met Ile Gly Ser Ala Leu Phe Ala Val Tyr Leu His Arg 
        35                  40                  45              


Arg Leu Asp Lys Ile Glu Asp Glu Arg Asn Leu His Glu Asp Phe Val 
    50                  55                  60                  


Phe Met Lys Thr Ile Gln Arg Cys Asn Thr Gly Glu Arg Ser Leu Ser 
65                  70                  75                  80  


Leu Leu Asn Cys Glu Glu Ile Lys Ser Gln Phe Glu Gly Phe Val Lys 
                85                  90                  95      


Asp Ile Met Leu Asn Lys Glu Glu Thr Lys Lys Glu Asn Ser Phe Glu 
            100                 105                 110         


Met Gln Lys Gly Asp Gln Asn Pro Gln Ile Ala Ala His Val Ile Ser 
        115                 120                 125             


Glu Ala Ser Ser Lys Thr Thr Ser Val Leu Gln Trp Ala Glu Lys Gly 
    130                 135                 140                 


Tyr Tyr Thr Met Ser Asn Asn Leu Val Thr Leu Glu Asn Gly Lys Gln 
145                 150                 155                 160 


Leu Thr Val Lys Arg Gln Gly Leu Tyr Tyr Ile Tyr Ala Gln Val Thr 
                165                 170                 175     


Phe Cys Ser Asn Arg Glu Ala Ser Ser Gln Ala Pro Phe Ile Ala Ser 
            180                 185                 190         


Leu Cys Leu Lys Ser Pro Gly Arg Phe Glu Arg Ile Leu Leu Arg Ala 
        195                 200                 205             


Ala Asn Thr His Ser Ser Ala Lys Pro Cys Gly Gln Gln Ser Ile His 
    210                 215                 220                 


Leu Gly Gly Val Phe Glu Leu Gln Pro Gly Ala Ser Val Phe Val Asn 
225                 230                 235                 240 


Val Thr Asp Pro Ser Gln Val Ser His Gly Thr Gly Phe Thr Ser Phe 
                245                 250                 255     


Gly Leu Leu Lys Leu 
            260     


<210>  225
<211>  361
<212>  PRT
<213>  Homo sapiens

<400>  225

Met Asp Lys Phe Trp Trp His Ala Ala Trp Gly Leu Cys Leu Val Pro 
1               5                   10                  15      


Leu Ser Leu Ala Gln Ile Asp Leu Asn Ile Thr Cys Arg Phe Ala Gly 
            20                  25                  30          


Val Phe His Val Glu Lys Asn Gly Arg Tyr Ser Ile Ser Arg Thr Glu 
        35                  40                  45              


Ala Ala Asp Leu Cys Lys Ala Phe Asn Ser Thr Leu Pro Thr Met Ala 
    50                  55                  60                  


Gln Met Glu Lys Ala Leu Ser Ile Gly Phe Glu Thr Cys Arg Tyr Gly 
65                  70                  75                  80  


Phe Ile Glu Gly His Val Val Ile Pro Arg Ile His Pro Asn Ser Ile 
                85                  90                  95      


Cys Ala Ala Asn Asn Thr Gly Val Tyr Ile Leu Thr Ser Asn Thr Ser 
            100                 105                 110         


Gln Tyr Asp Thr Tyr Cys Phe Asn Ala Ser Ala Pro Pro Glu Glu Asp 
        115                 120                 125             


Cys Thr Ser Val Thr Asp Leu Pro Asn Ala Phe Asp Gly Pro Ile Thr 
    130                 135                 140                 


Ile Thr Ile Val Asn Arg Asp Gly Thr Arg Tyr Val Gln Lys Gly Glu 
145                 150                 155                 160 


Tyr Arg Thr Asn Pro Glu Asp Ile Tyr Pro Ser Asn Pro Thr Asp Asp 
                165                 170                 175     


Asp Val Ser Ser Gly Ser Ser Ser Glu Arg Ser Ser Thr Ser Gly Gly 
            180                 185                 190         


Tyr Ile Phe Tyr Thr Phe Ser Thr Val His Pro Ile Pro Asp Glu Asp 
        195                 200                 205             


Ser Pro Trp Ile Thr Asp Ser Thr Asp Arg Ile Pro Ala Thr Arg Asp 
    210                 215                 220                 


Gln Asp Thr Phe His Pro Ser Gly Gly Ser His Thr Thr His Gly Ser 
225                 230                 235                 240 


Glu Ser Asp Gly His Ser His Gly Ser Gln Glu Gly Gly Ala Asn Thr 
                245                 250                 255     


Thr Ser Gly Pro Ile Arg Thr Pro Gln Ile Pro Glu Trp Leu Ile Ile 
            260                 265                 270         


Leu Ala Ser Leu Leu Ala Leu Ala Leu Ile Leu Ala Val Cys Ile Ala 
        275                 280                 285             


Val Asn Ser Arg Arg Arg Cys Gly Gln Lys Lys Lys Leu Val Ile Asn 
    290                 295                 300                 


Ser Gly Asn Gly Ala Val Glu Asp Arg Lys Pro Ser Gly Leu Asn Gly 
305                 310                 315                 320 


Glu Ala Ser Lys Ser Gln Glu Met Val His Leu Val Asn Lys Glu Ser 
                325                 330                 335     


Ser Glu Thr Pro Asp Gln Phe Met Thr Ala Asp Glu Thr Arg Asn Leu 
            340                 345                 350         


Gln Asn Val Asp Met Lys Ile Gly Val 
        355                 360     


<210>  226
<211>  87
<212>  PRT
<213>  Homo sapiens

<400>  226

Met Thr Met Tyr Leu Trp Leu Lys Leu Leu Ala Phe Gly Phe Ala Phe 
1               5                   10                  15      


Leu Asp Thr Glu Val Phe Val Thr Gly Gln Ser Pro Thr Pro Ser Pro 
            20                  25                  30          


Thr Gly His Leu Gln Ala Glu Glu Gln Gly Ser Gln Ser Lys Ser Pro 
        35                  40                  45              


Asn Leu Lys Ser Arg Glu Ala Asp Ser Ser Ala Phe Ser Trp Trp Pro 
    50                  55                  60                  


Lys Ala Arg Glu Pro Leu Thr Asn His Trp Ser Lys Ser Lys Ser Pro 
65                  70                  75                  80  


Lys Ala Glu Glu Leu Gly Val 
                85          


<210>  227
<211>  323
<212>  PRT
<213>  Homo sapiens

<400>  227

Met Trp Pro Leu Val Ala Ala Leu Leu Leu Gly Ser Ala Cys Cys Gly 
1               5                   10                  15      


Ser Ala Gln Leu Leu Phe Asn Lys Thr Lys Ser Val Glu Phe Thr Phe 
            20                  25                  30          


Cys Asn Asp Thr Val Val Ile Pro Cys Phe Val Thr Asn Met Glu Ala 
        35                  40                  45              


Gln Asn Thr Thr Glu Val Tyr Val Lys Trp Lys Phe Lys Gly Arg Asp 
    50                  55                  60                  


Ile Tyr Thr Phe Asp Gly Ala Leu Asn Lys Ser Thr Val Pro Thr Asp 
65                  70                  75                  80  


Phe Ser Ser Ala Lys Ile Glu Val Ser Gln Leu Leu Lys Gly Asp Ala 
                85                  90                  95      


Ser Leu Lys Met Asp Lys Ser Asp Ala Val Ser His Thr Gly Asn Tyr 
            100                 105                 110         


Thr Cys Glu Val Thr Glu Leu Thr Arg Glu Gly Glu Thr Ile Ile Glu 
        115                 120                 125             


Leu Lys Tyr Arg Val Val Ser Trp Phe Ser Pro Asn Glu Asn Ile Leu 
    130                 135                 140                 


Ile Val Ile Phe Pro Ile Phe Ala Ile Leu Leu Phe Trp Gly Gln Phe 
145                 150                 155                 160 


Gly Ile Lys Thr Leu Lys Tyr Arg Ser Gly Gly Met Asp Glu Lys Thr 
                165                 170                 175     


Ile Ala Leu Leu Val Ala Gly Leu Val Ile Thr Val Ile Val Ile Val 
            180                 185                 190         


Gly Ala Ile Leu Phe Val Pro Gly Glu Tyr Ser Leu Lys Asn Ala Thr 
        195                 200                 205             


Gly Leu Gly Leu Ile Val Thr Ser Thr Gly Ile Leu Ile Leu Leu His 
    210                 215                 220                 


Tyr Tyr Val Phe Ser Thr Ala Ile Gly Leu Thr Ser Phe Val Ile Ala 
225                 230                 235                 240 


Ile Leu Val Ile Gln Val Ile Ala Tyr Ile Leu Ala Val Val Gly Leu 
                245                 250                 255     


Ser Leu Cys Ile Ala Ala Cys Ile Pro Met His Gly Pro Leu Leu Ile 
            260                 265                 270         


Ser Gly Leu Ser Ile Leu Ala Leu Ala Gln Leu Leu Gly Leu Val Tyr 
        275                 280                 285             


Met Lys Phe Val Ala Ser Asn Gln Lys Thr Ile Gln Pro Pro Arg Lys 
    290                 295                 300                 


Ala Val Glu Glu Pro Leu Asn Ala Phe Lys Glu Ser Lys Gly Met Met 
305                 310                 315                 320 


Asn Asp Glu 
            


<210>  228
<211>  329
<212>  PRT
<213>  Homo sapiens

<400>  228

Met Asp Pro Gln Cys Thr Met Gly Leu Ser Asn Ile Leu Phe Val Met 
1               5                   10                  15      


Ala Phe Leu Leu Ser Gly Ala Ala Pro Leu Lys Ile Gln Ala Tyr Phe 
            20                  25                  30          


Asn Glu Thr Ala Asp Leu Pro Cys Gln Phe Ala Asn Ser Gln Asn Gln 
        35                  40                  45              


Ser Leu Ser Glu Leu Val Val Phe Trp Gln Asp Gln Glu Asn Leu Val 
    50                  55                  60                  


Leu Asn Glu Val Tyr Leu Gly Lys Glu Lys Phe Asp Ser Val His Ser 
65                  70                  75                  80  


Lys Tyr Met Gly Arg Thr Ser Phe Asp Ser Asp Ser Trp Thr Leu Arg 
                85                  90                  95      


Leu His Asn Leu Gln Ile Lys Asp Lys Gly Leu Tyr Gln Cys Ile Ile 
            100                 105                 110         


His His Lys Lys Pro Thr Gly Met Ile Arg Ile His Gln Met Asn Ser 
        115                 120                 125             


Glu Leu Ser Val Leu Ala Asn Phe Ser Gln Pro Glu Ile Val Pro Ile 
    130                 135                 140                 


Ser Asn Ile Thr Glu Asn Val Tyr Ile Asn Leu Thr Cys Ser Ser Ile 
145                 150                 155                 160 


His Gly Tyr Pro Glu Pro Lys Lys Met Ser Val Leu Leu Arg Thr Lys 
                165                 170                 175     


Asn Ser Thr Ile Glu Tyr Asp Gly Val Met Gln Lys Ser Gln Asp Asn 
            180                 185                 190         


Val Thr Glu Leu Tyr Asp Val Ser Ile Ser Leu Ser Val Ser Phe Pro 
        195                 200                 205             


Asp Val Thr Ser Asn Met Thr Ile Phe Cys Ile Leu Glu Thr Asp Lys 
    210                 215                 220                 


Thr Arg Leu Leu Ser Ser Pro Phe Ser Ile Glu Leu Glu Asp Pro Gln 
225                 230                 235                 240 


Pro Pro Pro Asp His Ile Pro Trp Ile Thr Ala Val Leu Pro Thr Val 
                245                 250                 255     


Ile Ile Cys Val Met Val Phe Cys Leu Ile Leu Trp Lys Trp Lys Lys 
            260                 265                 270         


Lys Lys Arg Pro Arg Asn Ser Tyr Lys Cys Gly Thr Asn Thr Met Glu 
        275                 280                 285             


Arg Glu Glu Ser Glu Gln Thr Lys Lys Arg Glu Lys Ile His Ile Pro 
    290                 295                 300                 


Glu Arg Ser Asp Glu Ala Gln Arg Val Phe Lys Ser Ser Lys Thr Ser 
305                 310                 315                 320 


Ser Cys Asp Lys Ser Asp Thr Cys Phe 
                325                 


<210>  229
<211>  635
<212>  PRT
<213>  Homo sapiens

<400>  229

Met Pro Ser Trp Ala Leu Phe Met Val Thr Ser Cys Leu Leu Leu Ala 
1               5                   10                  15      


Pro Gln Asn Leu Ala Gln Val Ser Ser Gln Asp Val Ser Leu Leu Ala 
            20                  25                  30          


Ser Asp Ser Glu Pro Leu Lys Cys Phe Ser Arg Thr Phe Glu Asp Leu 
        35                  40                  45              


Thr Cys Phe Trp Asp Glu Glu Glu Ala Ala Pro Ser Gly Thr Tyr Gln 
    50                  55                  60                  


Leu Leu Tyr Ala Tyr Pro Arg Glu Lys Pro Arg Ala Cys Pro Leu Ser 
65                  70                  75                  80  


Ser Gln Ser Met Pro His Phe Gly Thr Arg Tyr Val Cys Gln Phe Pro 
                85                  90                  95      


Asp Gln Glu Glu Val Arg Leu Phe Phe Pro Leu His Leu Trp Val Lys 
            100                 105                 110         


Asn Val Phe Leu Asn Gln Thr Arg Thr Gln Arg Val Leu Phe Val Asp 
        115                 120                 125             


Ser Val Gly Leu Pro Ala Pro Pro Ser Ile Ile Lys Ala Met Gly Gly 
    130                 135                 140                 


Ser Gln Pro Gly Glu Leu Gln Ile Ser Trp Glu Glu Pro Ala Pro Glu 
145                 150                 155                 160 


Ile Ser Asp Phe Leu Arg Tyr Glu Leu Arg Tyr Gly Pro Arg Asp Pro 
                165                 170                 175     


Lys Asn Ser Thr Gly Pro Thr Val Ile Gln Leu Ile Ala Thr Glu Thr 
            180                 185                 190         


Cys Cys Pro Ala Leu Gln Arg Pro His Ser Ala Ser Ala Leu Asp Gln 
        195                 200                 205             


Ser Pro Cys Ala Gln Pro Thr Met Pro Trp Gln Asp Gly Pro Lys Gln 
    210                 215                 220                 


Thr Ser Pro Ser Arg Glu Ala Ser Ala Leu Thr Ala Glu Gly Gly Ser 
225                 230                 235                 240 


Cys Leu Ile Ser Gly Leu Gln Pro Gly Asn Ser Tyr Trp Leu Gln Leu 
                245                 250                 255     


Arg Ser Glu Pro Asp Gly Ile Ser Leu Gly Gly Ser Trp Gly Ser Trp 
            260                 265                 270         


Ser Leu Pro Val Thr Val Asp Leu Pro Gly Asp Ala Val Ala Leu Gly 
        275                 280                 285             


Leu Gln Cys Phe Thr Leu Asp Leu Lys Asn Val Thr Cys Gln Trp Gln 
    290                 295                 300                 


Gln Gln Asp His Ala Ser Ser Gln Gly Phe Phe Tyr His Ser Arg Ala 
305                 310                 315                 320 


Arg Cys Cys Pro Arg Asp Arg Tyr Pro Ile Trp Glu Asn Cys Glu Glu 
                325                 330                 335     


Glu Glu Lys Thr Asn Pro Gly Leu Gln Thr Pro Gln Phe Ser Arg Cys 
            340                 345                 350         


His Phe Lys Ser Arg Asn Asp Ser Ile Ile His Ile Leu Val Glu Val 
        355                 360                 365             


Thr Thr Ala Pro Gly Thr Val His Ser Tyr Leu Gly Ser Pro Phe Trp 
    370                 375                 380                 


Ile His Gln Ala Val Arg Leu Pro Thr Pro Asn Leu His Trp Arg Glu 
385                 390                 395                 400 


Ile Ser Ser Gly His Leu Glu Leu Glu Trp Gln His Pro Ser Ser Trp 
                405                 410                 415     


Ala Ala Gln Glu Thr Cys Tyr Gln Leu Arg Tyr Thr Gly Glu Gly His 
            420                 425                 430         


Gln Asp Trp Lys Val Leu Glu Pro Pro Leu Gly Ala Arg Gly Gly Thr 
        435                 440                 445             


Leu Glu Leu Arg Pro Arg Ser Arg Tyr Arg Leu Gln Leu Arg Ala Arg 
    450                 455                 460                 


Leu Asn Gly Pro Thr Tyr Gln Gly Pro Trp Ser Ser Trp Ser Asp Pro 
465                 470                 475                 480 


Thr Arg Val Glu Thr Ala Thr Glu Thr Ala Trp Ile Ser Leu Val Thr 
                485                 490                 495     


Ala Leu His Leu Val Leu Gly Leu Ser Ala Val Leu Gly Leu Leu Leu 
            500                 505                 510         


Leu Arg Trp Gln Phe Pro Ala His Tyr Arg Arg Leu Arg His Ala Leu 
        515                 520                 525             


Trp Pro Ser Leu Pro Asp Leu His Arg Val Leu Gly Gln Tyr Leu Arg 
    530                 535                 540                 


Asp Thr Ala Ala Leu Ser Pro Pro Lys Ala Thr Val Ser Asp Thr Cys 
545                 550                 555                 560 


Glu Glu Val Glu Pro Ser Leu Leu Glu Ile Leu Pro Lys Ser Ser Glu 
                565                 570                 575     


Arg Thr Pro Leu Pro Leu Cys Ser Ser Gln Ala Gln Met Asp Tyr Arg 
            580                 585                 590         


Arg Leu Gln Pro Ser Cys Leu Gly Thr Met Pro Leu Ser Val Cys Pro 
        595                 600                 605             


Pro Met Ala Glu Ser Gly Ser Cys Cys Thr Thr His Ile Ala Asn His 
    610                 615                 620                 


Ser Tyr Leu Pro Leu Ser Tyr Trp Gln Gln Pro 
625                 630                 635 


<210>  230
<211>  352
<212>  PRT
<213>  Homo sapiens

<400>  230

Met Ala Arg Met Gly Leu Ala Gly Ala Ala Gly Arg Trp Trp Gly Leu 
1               5                   10                  15      


Ala Leu Gly Leu Thr Ala Phe Phe Leu Pro Gly Val His Ser Gln Val 
            20                  25                  30          


Val Gln Val Asn Asp Ser Met Tyr Gly Phe Ile Gly Thr Asp Val Val 
        35                  40                  45              


Leu His Cys Ser Phe Ala Asn Pro Leu Pro Ser Val Lys Ile Thr Gln 
    50                  55                  60                  


Val Thr Trp Gln Lys Ser Thr Asn Gly Ser Lys Gln Asn Val Ala Ile 
65                  70                  75                  80  


Tyr Asn Pro Ser Met Gly Val Ser Val Leu Ala Pro Tyr Arg Glu Arg 
                85                  90                  95      


Val Glu Phe Leu Arg Pro Ser Phe Thr Asp Gly Thr Ile Arg Leu Ser 
            100                 105                 110         


Arg Leu Glu Leu Glu Asp Glu Gly Val Tyr Ile Cys Glu Phe Ala Thr 
        115                 120                 125             


Phe Pro Thr Gly Asn Arg Glu Ser Gln Leu Asn Leu Thr Val Met Ala 
    130                 135                 140                 


Lys Pro Thr Asn Trp Ile Glu Gly Thr Gln Ala Val Leu Arg Ala Lys 
145                 150                 155                 160 


Lys Gly Gln Asp Asp Lys Val Leu Val Ala Thr Cys Thr Ser Ala Asn 
                165                 170                 175     


Gly Lys Pro Pro Ser Val Val Ser Trp Glu Thr Arg Leu Lys Gly Glu 
            180                 185                 190         


Ala Glu Tyr Gln Glu Ile Arg Asn Pro Asn Gly Thr Val Thr Val Ile 
        195                 200                 205             


Ser Arg Tyr Arg Leu Val Pro Ser Arg Glu Ala His Gln Gln Ser Leu 
    210                 215                 220                 


Ala Cys Ile Val Asn Tyr His Met Asp Arg Phe Lys Glu Ser Leu Thr 
225                 230                 235                 240 


Leu Asn Val Gln Tyr Glu Pro Glu Val Thr Ile Glu Gly Phe Asp Gly 
                245                 250                 255     


Asn Trp Tyr Leu Gln Arg Met Asp Val Lys Leu Thr Cys Lys Ala Asp 
            260                 265                 270         


Ala Asn Pro Pro Ala Thr Glu Tyr His Trp Thr Thr Leu Asn Gly Ser 
        275                 280                 285             


Leu Pro Lys Gly Val Glu Ala Gln Asn Arg Thr Leu Phe Phe Lys Gly 
    290                 295                 300                 


Pro Ile Asn Tyr Ser Leu Ala Gly Thr Tyr Ile Cys Glu Ala Thr Asn 
305                 310                 315                 320 


Pro Ile Gly Thr Arg Ser Gly Gln Val Glu Val Asn Ile Thr Ala Phe 
                325                 330                 335     


Cys Gln Leu Ile Tyr Pro Gly Lys Gly Arg Thr Arg Ala Arg Met Phe 
            340                 345                 350         


<210>  231
<211>  972
<212>  PRT
<213>  Homo sapiens

<400>  231

Met Gly Pro Gly Val Leu Leu Leu Leu Leu Val Ala Thr Ala Trp His 
1               5                   10                  15      


Gly Gln Gly Ile Pro Val Ile Glu Pro Ser Val Pro Glu Leu Val Val 
            20                  25                  30          


Lys Pro Gly Ala Thr Val Thr Leu Arg Cys Val Gly Asn Gly Ser Val 
        35                  40                  45              


Glu Trp Asp Gly Pro Pro Ser Pro His Trp Thr Leu Tyr Ser Asp Gly 
    50                  55                  60                  


Ser Ser Ser Ile Leu Ser Thr Asn Asn Ala Thr Phe Gln Asn Thr Gly 
65                  70                  75                  80  


Thr Tyr Arg Cys Thr Glu Pro Gly Asp Pro Leu Gly Gly Ser Ala Ala 
                85                  90                  95      


Ile His Leu Tyr Val Lys Asp Pro Ala Arg Pro Trp Asn Val Leu Ala 
            100                 105                 110         


Gln Glu Val Val Val Phe Glu Asp Gln Asp Ala Leu Leu Pro Cys Leu 
        115                 120                 125             


Leu Thr Asp Pro Val Leu Glu Ala Gly Val Ser Leu Val Arg Val Arg 
    130                 135                 140                 


Gly Arg Pro Leu Met Arg His Thr Asn Tyr Ser Phe Ser Pro Trp His 
145                 150                 155                 160 


Gly Phe Thr Ile His Arg Ala Lys Phe Ile Gln Ser Gln Asp Tyr Gln 
                165                 170                 175     


Cys Ser Ala Leu Met Gly Gly Arg Lys Val Met Ser Ile Ser Ile Arg 
            180                 185                 190         


Leu Lys Val Gln Lys Val Ile Pro Gly Pro Pro Ala Leu Thr Leu Val 
        195                 200                 205             


Pro Ala Glu Leu Val Arg Ile Arg Gly Glu Ala Ala Gln Ile Val Cys 
    210                 215                 220                 


Ser Ala Ser Ser Val Asp Val Asn Phe Asp Val Phe Leu Gln His Asn 
225                 230                 235                 240 


Asn Thr Lys Leu Ala Ile Pro Gln Gln Ser Asp Phe His Asn Asn Arg 
                245                 250                 255     


Tyr Gln Lys Val Leu Thr Leu Asn Leu Asp Gln Val Asp Phe Gln His 
            260                 265                 270         


Ala Gly Asn Tyr Ser Cys Val Ala Ser Asn Val Gln Gly Lys His Ser 
        275                 280                 285             


Thr Ser Met Phe Phe Arg Val Val Glu Ser Ala Tyr Leu Asn Leu Ser 
    290                 295                 300                 


Ser Glu Gln Asn Leu Ile Gln Glu Val Thr Val Gly Glu Gly Leu Asn 
305                 310                 315                 320 


Leu Lys Val Met Val Glu Ala Tyr Pro Gly Leu Gln Gly Phe Asn Trp 
                325                 330                 335     


Thr Tyr Leu Gly Pro Phe Ser Asp His Gln Pro Glu Pro Lys Leu Ala 
            340                 345                 350         


Asn Ala Thr Thr Lys Asp Thr Tyr Arg His Thr Phe Thr Leu Ser Leu 
        355                 360                 365             


Pro Arg Leu Lys Pro Ser Glu Ala Gly Arg Tyr Ser Phe Leu Ala Arg 
    370                 375                 380                 


Asn Pro Gly Gly Trp Arg Ala Leu Thr Phe Glu Leu Thr Leu Arg Tyr 
385                 390                 395                 400 


Pro Pro Glu Val Ser Val Ile Trp Thr Phe Ile Asn Gly Ser Gly Thr 
                405                 410                 415     


Leu Leu Cys Ala Ala Ser Gly Tyr Pro Gln Pro Asn Val Thr Trp Leu 
            420                 425                 430         


Gln Cys Ser Gly His Thr Asp Arg Cys Asp Glu Ala Gln Val Leu Gln 
        435                 440                 445             


Val Trp Asp Asp Pro Tyr Pro Glu Val Leu Ser Gln Glu Pro Phe His 
    450                 455                 460                 


Lys Val Thr Val Gln Ser Leu Leu Thr Val Glu Thr Leu Glu His Asn 
465                 470                 475                 480 


Gln Thr Tyr Glu Cys Arg Ala His Asn Ser Val Gly Ser Gly Ser Trp 
                485                 490                 495     


Ala Phe Ile Pro Ile Ser Ala Gly Ala His Thr His Pro Pro Asp Glu 
            500                 505                 510         


Phe Leu Phe Thr Pro Val Val Val Ala Cys Met Ser Ile Met Ala Leu 
        515                 520                 525             


Leu Leu Leu Leu Leu Leu Leu Leu Leu Tyr Lys Tyr Lys Gln Lys Pro 
    530                 535                 540                 


Lys Tyr Gln Val Arg Trp Lys Ile Ile Glu Ser Tyr Glu Gly Asn Ser 
545                 550                 555                 560 


Tyr Thr Phe Ile Asp Pro Thr Gln Leu Pro Tyr Asn Glu Lys Trp Glu 
                565                 570                 575     


Phe Pro Arg Asn Asn Leu Gln Phe Gly Lys Thr Leu Gly Ala Gly Ala 
            580                 585                 590         


Phe Gly Lys Val Val Glu Ala Thr Ala Phe Gly Leu Gly Lys Glu Asp 
        595                 600                 605             


Ala Val Leu Lys Val Ala Val Lys Met Leu Lys Ser Thr Ala His Ala 
    610                 615                 620                 


Asp Glu Lys Glu Ala Leu Met Ser Glu Leu Lys Ile Met Ser His Leu 
625                 630                 635                 640 


Gly Gln His Glu Asn Ile Val Asn Leu Leu Gly Ala Cys Thr His Gly 
                645                 650                 655     


Gly Pro Val Leu Val Ile Thr Glu Tyr Cys Cys Tyr Gly Asp Leu Leu 
            660                 665                 670         


Asn Phe Leu Arg Arg Lys Ala Glu Ala Met Leu Gly Pro Ser Leu Ser 
        675                 680                 685             


Pro Gly Gln Asp Pro Glu Gly Gly Val Asp Tyr Lys Asn Ile His Leu 
    690                 695                 700                 


Glu Lys Lys Tyr Val Arg Arg Asp Ser Gly Phe Ser Ser Gln Gly Val 
705                 710                 715                 720 


Asp Thr Tyr Val Glu Met Arg Pro Val Ser Thr Ser Ser Asn Asp Ser 
                725                 730                 735     


Phe Ser Glu Gln Asp Leu Asp Lys Glu Asp Gly Arg Pro Leu Glu Leu 
            740                 745                 750         


Arg Asp Leu Leu His Phe Ser Ser Gln Val Ala Gln Gly Met Ala Phe 
        755                 760                 765             


Leu Ala Ser Lys Asn Cys Ile His Arg Asp Val Ala Ala Arg Asn Val 
    770                 775                 780                 


Leu Leu Thr Asn Gly His Val Ala Lys Ile Gly Asp Phe Gly Leu Ala 
785                 790                 795                 800 


Arg Asp Ile Met Asn Asp Ser Asn Tyr Ile Val Lys Gly Asn Ala Arg 
                805                 810                 815     


Leu Pro Val Lys Trp Met Ala Pro Glu Ser Ile Phe Asp Cys Val Tyr 
            820                 825                 830         


Thr Val Gln Ser Asp Val Trp Ser Tyr Gly Ile Leu Leu Trp Glu Ile 
        835                 840                 845             


Phe Ser Leu Gly Leu Asn Pro Tyr Pro Gly Ile Leu Val Asn Ser Lys 
    850                 855                 860                 


Phe Tyr Lys Leu Val Lys Asp Gly Tyr Gln Met Ala Gln Pro Ala Phe 
865                 870                 875                 880 


Ala Pro Lys Asn Ile Tyr Ser Ile Met Gln Ala Cys Trp Ala Leu Glu 
                885                 890                 895     


Pro Thr His Arg Pro Thr Phe Gln Gln Ile Cys Ser Phe Leu Gln Glu 
            900                 905                 910         


Gln Ala Gln Glu Asp Arg Arg Glu Arg Asp Tyr Thr Asn Leu Pro Ser 
        915                 920                 925             


Ser Ser Arg Ser Gly Gly Ser Gly Ser Ser Ser Ser Glu Leu Glu Glu 
    930                 935                 940                 


Glu Ser Ser Ser Glu His Leu Thr Cys Cys Glu Gln Gly Asp Ile Ala 
945                 950                 955                 960 


Gln Pro Leu Leu Gln Pro Asn Asn Tyr Gln Phe Cys 
                965                 970         


<210>  232
<211>  975
<212>  PRT
<213>  Homo sapiens

<400>  232

Met Arg Gly Ala Arg Gly Ala Trp Asp Phe Leu Cys Val Leu Leu Leu 
1               5                   10                  15      


Leu Leu Arg Val Gln Thr Gly Ser Ser Gln Pro Ser Val Ser Pro Gly 
            20                  25                  30          


Glu Pro Ser Pro Pro Ser Ile His Pro Gly Lys Ser Asp Leu Ile Val 
        35                  40                  45              


Arg Val Gly Asp Glu Ile Arg Leu Leu Cys Thr Asp Pro Gly Phe Val 
    50                  55                  60                  


Lys Trp Thr Phe Glu Ile Leu Asp Glu Thr Asn Glu Asn Lys Gln Asn 
65                  70                  75                  80  


Glu Trp Ile Thr Glu Lys Ala Glu Ala Thr Asn Thr Gly Lys Tyr Thr 
                85                  90                  95      


Cys Thr Asn Lys His Gly Leu Ser Asn Ser Ile Tyr Val Phe Val Arg 
            100                 105                 110         


Asp Pro Ala Lys Leu Phe Leu Val Asp Arg Ser Leu Tyr Gly Lys Glu 
        115                 120                 125             


Asp Asn Asp Thr Leu Val Arg Cys Pro Leu Thr Asp Pro Glu Val Thr 
    130                 135                 140                 


Asn Tyr Ser Leu Lys Gly Cys Gln Gly Lys Pro Leu Pro Lys Asp Leu 
145                 150                 155                 160 


Arg Phe Ile Pro Asp Pro Lys Ala Gly Ile Met Ile Lys Ser Val Lys 
                165                 170                 175     


Arg Ala Tyr His Arg Leu Cys Leu His Cys Ser Val Asp Gln Glu Gly 
            180                 185                 190         


Lys Ser Val Leu Ser Glu Lys Phe Ile Leu Lys Val Arg Pro Ala Phe 
        195                 200                 205             


Lys Ala Val Pro Val Val Ser Val Ser Lys Ala Ser Tyr Leu Leu Arg 
    210                 215                 220                 


Glu Gly Glu Glu Phe Thr Val Thr Cys Thr Ile Lys Asp Val Ser Ser 
225                 230                 235                 240 


Ser Val Tyr Ser Thr Trp Lys Arg Glu Asn Ser Gln Thr Lys Leu Gln 
                245                 250                 255     


Glu Lys Tyr Asn Ser Trp His His Gly Asp Phe Asn Tyr Glu Arg Gln 
            260                 265                 270         


Ala Thr Leu Thr Ile Ser Ser Ala Arg Val Asn Asp Ser Gly Val Phe 
        275                 280                 285             


Met Cys Tyr Ala Asn Asn Thr Phe Gly Ser Ala Asn Val Thr Thr Thr 
    290                 295                 300                 


Leu Glu Val Val Asp Lys Gly Phe Ile Asn Ile Phe Pro Met Ile Asn 
305                 310                 315                 320 


Thr Thr Val Phe Val Asn Asp Gly Glu Asn Val Asp Leu Ile Val Glu 
                325                 330                 335     


Tyr Glu Ala Phe Pro Lys Pro Glu His Gln Gln Trp Ile Tyr Met Asn 
            340                 345                 350         


Arg Thr Phe Thr Asp Lys Trp Glu Asp Tyr Pro Lys Ser Glu Asn Glu 
        355                 360                 365             


Ser Asn Ile Arg Tyr Val Ser Glu Leu His Leu Thr Arg Leu Lys Gly 
    370                 375                 380                 


Thr Glu Gly Gly Thr Tyr Thr Phe Leu Val Ser Asn Ser Asp Val Asn 
385                 390                 395                 400 


Ala Ala Ile Ala Phe Asn Val Tyr Val Asn Thr Lys Pro Glu Ile Leu 
                405                 410                 415     


Thr Tyr Asp Arg Leu Val Asn Gly Met Leu Gln Cys Val Ala Ala Gly 
            420                 425                 430         


Phe Pro Glu Pro Thr Ile Asp Trp Tyr Phe Cys Pro Gly Thr Glu Gln 
        435                 440                 445             


Arg Cys Ser Ala Ser Val Leu Pro Val Asp Val Gln Thr Leu Asn Ser 
    450                 455                 460                 


Ser Gly Pro Pro Phe Gly Lys Leu Val Val Gln Ser Ser Ile Asp Ser 
465                 470                 475                 480 


Ser Ala Phe Lys His Asn Gly Thr Val Glu Cys Lys Ala Tyr Asn Asp 
                485                 490                 495     


Val Gly Lys Thr Ser Ala Tyr Phe Asn Phe Ala Phe Lys Gly Asn Asn 
            500                 505                 510         


Lys Glu Gln Ile His Pro His Thr Leu Phe Thr Pro Leu Leu Ile Gly 
        515                 520                 525             


Phe Val Ile Val Ala Gly Met Met Cys Ile Ile Val Met Ile Leu Thr 
    530                 535                 540                 


Tyr Lys Tyr Leu Gln Lys Pro Met Tyr Glu Val Gln Trp Lys Val Val 
545                 550                 555                 560 


Glu Glu Ile Asn Gly Asn Asn Tyr Val Tyr Ile Asp Pro Thr Gln Leu 
                565                 570                 575     


Pro Tyr Asp His Lys Trp Glu Phe Pro Arg Asn Arg Leu Ser Phe Gly 
            580                 585                 590         


Lys Thr Leu Gly Ala Gly Ala Phe Gly Lys Val Val Glu Ala Thr Ala 
        595                 600                 605             


Tyr Gly Leu Ile Lys Ser Asp Ala Ala Met Thr Val Ala Val Lys Met 
    610                 615                 620                 


Leu Lys Pro Ser Ala His Leu Thr Glu Arg Glu Ala Leu Met Ser Glu 
625                 630                 635                 640 


Leu Lys Val Leu Ser Tyr Leu Gly Asn His Met Asn Ile Val Asn Leu 
                645                 650                 655     


Leu Gly Ala Cys Thr Ile Gly Gly Pro Thr Leu Val Ile Thr Glu Tyr 
            660                 665                 670         


Cys Cys Tyr Gly Asp Leu Leu Asn Phe Leu Arg Arg Lys Arg Asp Ser 
        675                 680                 685             


Phe Ile Cys Ser Lys Gln Glu Asp His Ala Glu Ala Ala Leu Tyr Lys 
    690                 695                 700                 


Asn Leu Leu His Ser Lys Glu Ser Ser Cys Asp Ser Thr Asn Glu Tyr 
705                 710                 715                 720 


Met Asp Met Lys Pro Gly Val Ser Tyr Val Val Pro Thr Lys Ala Asp 
                725                 730                 735     


Lys Arg Arg Ser Val Arg Ile Gly Ser Tyr Ile Glu Arg Asp Val Thr 
            740                 745                 750         


Pro Ala Ile Met Glu Asp Asp Glu Leu Ala Leu Asp Leu Glu Asp Leu 
        755                 760                 765             


Leu Ser Phe Ser Tyr Gln Val Ala Lys Gly Met Ala Phe Leu Ala Ser 
    770                 775                 780                 


Lys Asn Cys Ile His Arg Asp Leu Ala Ala Arg Asn Ile Leu Leu Thr 
785                 790                 795                 800 


His Gly Arg Ile Thr Lys Ile Cys Asp Phe Gly Leu Ala Arg Asp Ile 
                805                 810                 815     


Lys Asn Asp Ser Asn Tyr Val Val Lys Gly Asn Ala Arg Leu Pro Val 
            820                 825                 830         


Lys Trp Met Ala Pro Glu Ser Ile Phe Asn Cys Val Tyr Thr Phe Glu 
        835                 840                 845             


Ser Asp Val Trp Ser Tyr Gly Ile Phe Leu Trp Glu Leu Phe Ser Leu 
    850                 855                 860                 


Gly Ser Ser Pro Tyr Pro Gly Met Pro Val Asp Ser Lys Phe Tyr Lys 
865                 870                 875                 880 


Met Ile Lys Glu Gly Phe Arg Met Leu Ser Pro Glu His Ala Pro Ala 
                885                 890                 895     


Glu Met Tyr Asp Ile Met Lys Thr Cys Trp Asp Ala Asp Pro Leu Lys 
            900                 905                 910         


Arg Pro Thr Phe Lys Gln Ile Val Gln Leu Ile Glu Lys Gln Ile Ser 
        915                 920                 925             


Glu Ser Thr Asn His Ile Tyr Ser Asn Leu Ala Asn Cys Ser Pro Asn 
    930                 935                 940                 


Arg Gln Lys Pro Val Val Asp His Ser Val Arg Ile Asn Ser Val Gly 
945                 950                 955                 960 


Ser Thr Ala Ser Ser Ser Gln Pro Leu Leu Val His Asp Asp Val 
                965                 970                 975 


<210>  233
<211>  439
<212>  PRT
<213>  Homo sapiens

<400>  233

Met Ile Ile Val Ala His Val Leu Leu Ile Leu Leu Gly Ala Thr Glu 
1               5                   10                  15      


Ile Leu Gln Ala Asp Leu Leu Pro Asp Glu Lys Ile Ser Leu Leu Pro 
            20                  25                  30          


Pro Val Asn Phe Thr Ile Lys Val Thr Gly Leu Ala Gln Val Leu Leu 
        35                  40                  45              


Gln Trp Lys Pro Asn Pro Asp Gln Glu Gln Arg Asn Val Asn Leu Glu 
    50                  55                  60                  


Tyr Gln Val Lys Ile Asn Ala Pro Lys Glu Asp Asp Tyr Glu Thr Arg 
65                  70                  75                  80  


Ile Thr Glu Ser Lys Cys Val Thr Ile Leu His Lys Gly Phe Ser Ala 
                85                  90                  95      


Ser Val Arg Thr Ile Leu Gln Asn Asp His Ser Leu Leu Ala Ser Ser 
            100                 105                 110         


Trp Ala Ser Ala Glu Leu His Ala Pro Pro Gly Ser Pro Gly Thr Ser 
        115                 120                 125             


Ile Val Asn Leu Thr Cys Thr Thr Asn Thr Thr Glu Asp Asn Tyr Ser 
    130                 135                 140                 


Arg Leu Arg Ser Tyr Gln Val Ser Leu His Cys Thr Trp Leu Val Gly 
145                 150                 155                 160 


Thr Asp Ala Pro Glu Asp Thr Gln Tyr Phe Leu Tyr Tyr Arg Tyr Gly 
                165                 170                 175     


Ser Trp Thr Glu Glu Cys Gln Glu Tyr Ser Lys Asp Thr Leu Gly Arg 
            180                 185                 190         


Asn Ile Ala Cys Trp Phe Pro Arg Thr Phe Ile Leu Ser Lys Gly Arg 
        195                 200                 205             


Asp Trp Leu Ala Val Leu Val Asn Gly Ser Ser Lys His Ser Ala Ile 
    210                 215                 220                 


Arg Pro Phe Asp Gln Leu Phe Ala Leu His Ala Ile Asp Gln Ile Asn 
225                 230                 235                 240 


Pro Pro Leu Asn Val Thr Ala Glu Ile Glu Gly Thr Arg Leu Ser Ile 
                245                 250                 255     


Gln Trp Glu Lys Pro Val Ser Ala Phe Pro Ile His Cys Phe Asp Tyr 
            260                 265                 270         


Glu Val Lys Ile His Asn Thr Arg Asn Gly Tyr Leu Gln Ile Glu Lys 
        275                 280                 285             


Leu Met Thr Asn Ala Phe Ile Ser Ile Ile Asp Asp Leu Ser Lys Tyr 
    290                 295                 300                 


Asp Val Gln Val Arg Ala Ala Val Ser Ser Met Cys Arg Glu Ala Gly 
305                 310                 315                 320 


Leu Trp Ser Glu Trp Ser Gln Pro Ile Tyr Val Gly Asn Asp Glu His 
                325                 330                 335     


Lys Pro Leu Arg Glu Trp Phe Val Ile Val Ile Met Ala Thr Ile Cys 
            340                 345                 350         


Phe Ile Leu Leu Ile Leu Ser Leu Ile Cys Lys Ile Cys His Leu Trp 
        355                 360                 365             


Ile Lys Leu Phe Pro Pro Ile Pro Ala Pro Lys Ser Asn Ile Lys Asp 
    370                 375                 380                 


Leu Phe Val Thr Thr Asn Tyr Glu Val Leu Cys Ile Phe Ile Tyr Ile 
385                 390                 395                 400 


Leu Asp Ser Ala Asp Asn Phe Leu Gln Lys Lys Lys Ala Gly Ser Ser 
                405                 410                 415     


Glu Thr Glu Ile Glu Val Ile Cys Tyr Ile Glu Lys Pro Gly Val Glu 
            420                 425                 430         


Thr Leu Glu Asp Ser Val Phe 
        435                 


<210>  234
<211>  818
<212>  PRT
<213>  Homo sapiens

<400>  234

Met Glu Asn Gln Asp Ala Leu Val Cys Ile Ser Glu Ser Val Pro Glu 
1               5                   10                  15      


Pro Ile Val Glu Trp Val Leu Cys Asp Ser Gln Gly Glu Ser Cys Lys 
            20                  25                  30          


Glu Glu Ser Pro Ala Val Val Lys Lys Glu Glu Lys Val Leu His Glu 
        35                  40                  45              


Leu Phe Gly Thr Asp Ile Arg Cys Cys Ala Arg Asn Glu Leu Gly Arg 
    50                  55                  60                  


Glu Cys Thr Arg Leu Phe Thr Ile Asp Leu Asn Gln Thr Pro Gln Thr 
65                  70                  75                  80  


Thr Leu Pro Gln Leu Phe Leu Lys Val Gly Glu Pro Leu Trp Ile Arg 
                85                  90                  95      


Cys Lys Ala Val His Val Asn His Gly Phe Gly Leu Thr Trp Glu Leu 
            100                 105                 110         


Glu Asn Lys Ala Leu Glu Glu Gly Asn Tyr Phe Glu Met Ser Thr Tyr 
        115                 120                 125             


Ser Thr Asn Arg Thr Met Ile Arg Ile Leu Phe Ala Phe Val Ser Ser 
    130                 135                 140                 


Val Ala Arg Asn Asp Thr Gly Tyr Tyr Thr Cys Ser Ser Ser Lys His 
145                 150                 155                 160 


Pro Ser Gln Ser Ala Leu Val Thr Ile Val Glu Lys Gly Phe Ile Asn 
                165                 170                 175     


Ala Thr Asn Ser Ser Glu Asp Tyr Glu Ile Asp Gln Tyr Glu Glu Phe 
            180                 185                 190         


Cys Phe Ser Val Arg Phe Lys Ala Tyr Pro Gln Ile Arg Cys Thr Trp 
        195                 200                 205             


Thr Phe Ser Arg Lys Ser Phe Pro Cys Glu Gln Lys Gly Leu Asp Asn 
    210                 215                 220                 


Gly Tyr Ser Ile Ser Lys Phe Cys Asn His Lys His Gln Pro Gly Glu 
225                 230                 235                 240 


Tyr Ile Phe His Ala Glu Asn Asp Asp Ala Gln Phe Thr Lys Met Phe 
                245                 250                 255     


Thr Leu Asn Ile Arg Arg Lys Pro Gln Val Leu Ala Glu Ala Ser Ala 
            260                 265                 270         


Ser Gln Ala Ser Cys Phe Ser Asp Gly Tyr Pro Leu Pro Ser Trp Thr 
        275                 280                 285             


Trp Lys Lys Cys Ser Asp Lys Ser Pro Asn Cys Thr Glu Glu Ile Thr 
    290                 295                 300                 


Glu Gly Val Trp Asn Arg Lys Ala Asn Arg Lys Val Phe Gly Gln Trp 
305                 310                 315                 320 


Val Ser Ser Ser Thr Leu Asn Met Ser Glu Ala Ile Lys Gly Phe Leu 
                325                 330                 335     


Val Lys Cys Cys Ala Tyr Asn Ser Leu Gly Thr Ser Cys Glu Thr Ile 
            340                 345                 350         


Leu Leu Asn Ser Pro Gly Pro Phe Pro Phe Ile Gln Asp Asn Ile Ser 
        355                 360                 365             


Phe Tyr Ala Thr Ile Gly Val Cys Leu Leu Phe Ile Val Val Leu Thr 
    370                 375                 380                 


Leu Leu Ile Cys His Lys Tyr Lys Lys Gln Phe Arg Tyr Glu Ser Gln 
385                 390                 395                 400 


Leu Gln Met Val Gln Val Thr Gly Ser Ser Asp Asn Glu Tyr Phe Tyr 
                405                 410                 415     


Val Asp Phe Arg Glu Tyr Glu Tyr Asp Leu Lys Trp Glu Phe Pro Arg 
            420                 425                 430         


Glu Asn Leu Glu Phe Gly Lys Val Leu Gly Ser Gly Ala Phe Gly Lys 
        435                 440                 445             


Val Met Asn Ala Thr Ala Tyr Gly Ile Ser Lys Thr Gly Val Ser Ile 
    450                 455                 460                 


Gln Val Ala Val Lys Met Leu Lys Glu Lys Ala Asp Ser Ser Glu Arg 
465                 470                 475                 480 


Glu Ala Leu Met Ser Glu Leu Lys Met Met Thr Gln Leu Gly Ser His 
                485                 490                 495     


Glu Asn Ile Val Asn Leu Leu Gly Ala Cys Thr Leu Ser Gly Pro Ile 
            500                 505                 510         


Tyr Leu Ile Phe Glu Tyr Cys Cys Tyr Gly Asp Leu Leu Asn Tyr Leu 
        515                 520                 525             


Arg Ser Lys Arg Glu Lys Phe His Arg Thr Trp Thr Glu Ile Phe Lys 
    530                 535                 540                 


Glu His Asn Phe Ser Phe Tyr Pro Thr Phe Gln Ser His Pro Asn Ser 
545                 550                 555                 560 


Ser Met Pro Gly Ser Arg Glu Val Gln Ile His Pro Asp Ser Asp Gln 
                565                 570                 575     


Ile Ser Gly Leu His Gly Asn Ser Phe His Ser Glu Asp Glu Ile Glu 
            580                 585                 590         


Tyr Glu Asn Gln Lys Arg Leu Glu Glu Glu Glu Asp Leu Asn Val Leu 
        595                 600                 605             


Thr Phe Glu Asp Leu Leu Cys Phe Ala Tyr Gln Val Ala Lys Gly Met 
    610                 615                 620                 


Glu Phe Leu Glu Phe Lys Ser Cys Val His Arg Asp Leu Ala Ala Arg 
625                 630                 635                 640 


Asn Val Leu Val Thr His Gly Lys Val Val Lys Ile Cys Asp Phe Gly 
                645                 650                 655     


Leu Ala Arg Asp Ile Met Ser Asp Ser Asn Tyr Val Val Arg Gly Asn 
            660                 665                 670         


Ala Arg Leu Pro Val Lys Trp Met Ala Pro Glu Ser Leu Phe Glu Gly 
        675                 680                 685             


Ile Tyr Thr Ile Lys Ser Asp Val Trp Ser Tyr Gly Ile Leu Leu Trp 
    690                 695                 700                 


Glu Ile Phe Ser Leu Gly Val Asn Pro Tyr Pro Gly Ile Pro Val Asp 
705                 710                 715                 720 


Ala Asn Phe Tyr Lys Leu Ile Gln Asn Gly Phe Lys Met Asp Gln Pro 
                725                 730                 735     


Phe Tyr Ala Thr Glu Glu Ile Tyr Ile Ile Met Gln Ser Cys Trp Ala 
            740                 745                 750         


Phe Asp Ser Arg Lys Arg Pro Ser Phe Pro Asn Leu Thr Ser Phe Leu 
        755                 760                 765             


Gly Cys Gln Leu Ala Asp Ala Glu Glu Ala Met Tyr Gln Asn Val Asp 
    770                 775                 780                 


Gly Arg Val Ser Glu Cys Pro His Thr Tyr Gln Asn Arg Arg Pro Phe 
785                 790                 795                 800 


Ser Arg Glu Met Asp Leu Gly Leu Leu Ser Pro Gln Ala Gln Val Glu 
                805                 810                 815     


Asp Ser 
        


<210>  235
<211>  423
<212>  PRT
<213>  Homo sapiens

<400>  235

Met Glu Gly Ile Ser Glu Asn Ala Pro Leu Pro Asn Val Pro Asn Ala 
1               5                   10                  15      


Pro Ser Asp Lys His Glu Asp Gly Lys Arg Pro Thr His Arg Arg Ser 
            20                  25                  30          


Ala Arg Leu Gly Glu Glu Val Pro Phe Val His Phe Leu Thr Leu Pro 
        35                  40                  45              


Pro Asn Ile Pro Gln Ala Pro Lys Gly Leu Arg Phe Lys Thr Ala Phe 
    50                  55                  60                  


Ser Leu Pro Thr Thr Ser Cys Leu Lys Pro Arg Met Ile Tyr Thr Ser 
65                  70                  75                  80  


Asp Asn Tyr Thr Glu Glu Met Gly Ser Gly Asp Tyr Asp Ser Met Lys 
                85                  90                  95      


Glu Pro Cys Phe Arg Glu Glu Asn Ala Asn Phe Asn Lys Ile Phe Leu 
            100                 105                 110         


Pro Thr Ile Tyr Ser Ile Ile Phe Leu Thr Gly Ile Val Gly Asn Gly 
        115                 120                 125             


Leu Val Ile Leu Val Met Gly Tyr Gln Lys Lys Leu Arg Ser Met Thr 
    130                 135                 140                 


Asp Lys Tyr Arg Leu His Leu Ser Val Ala Asp Leu Leu Phe Val Ile 
145                 150                 155                 160 


Thr Leu Pro Phe Trp Ala Val Asp Ala Val Ala Asn Trp Tyr Phe Gly 
                165                 170                 175     


Asn Phe Leu Cys Lys Ala Val His Val Ile Tyr Thr Val Asn Leu Tyr 
            180                 185                 190         


Ser Ser Val Leu Ile Leu Ala Phe Ile Ser Leu Asp Arg Tyr Leu Ala 
        195                 200                 205             


Ile Val His Ala Thr Asn Ser Gln Arg Pro Arg Lys Leu Leu Ala Glu 
    210                 215                 220                 


Lys Val Val Tyr Val Gly Val Trp Ile Pro Ala Leu Leu Leu Thr Ile 
225                 230                 235                 240 


Pro Asp Phe Ile Phe Ala Asn Val Ser Glu Ala Asp Asp Arg Tyr Ile 
                245                 250                 255     


Cys Asp Arg Phe Tyr Pro Asn Asp Leu Trp Val Val Val Phe Gln Phe 
            260                 265                 270         


Gln His Ile Met Val Gly Leu Ile Leu Pro Gly Ile Val Ile Leu Ser 
        275                 280                 285             


Cys Tyr Cys Ile Ile Ile Ser Lys Leu Ser His Ser Lys Gly His Gln 
    290                 295                 300                 


Lys Arg Lys Ala Leu Lys Thr Thr Val Ile Leu Ile Leu Ala Phe Phe 
305                 310                 315                 320 


Ala Cys Trp Leu Pro Tyr Tyr Ile Gly Ile Ser Ile Asp Ser Phe Ile 
                325                 330                 335     


Leu Leu Glu Ile Ile Lys Gln Gly Cys Glu Phe Glu Asn Thr Val His 
            340                 345                 350         


Lys Trp Ile Ser Ile Thr Glu Ala Leu Ala Phe Phe His Cys Cys Leu 
        355                 360                 365             


Asn Pro Ile Leu Tyr Ala Phe Leu Gly Ala Lys Phe Lys Thr Ser Ala 
    370                 375                 380                 


Gln His Ala Leu Thr Ser Val Ser Arg Gly Ser Ser Leu Lys Ile Leu 
385                 390                 395                 400 


Ser Lys Gly Lys Arg Gly Gly His Ser Ser Val Ser Thr Glu Ser Glu 
                405                 410                 415     


Ser Ser Ser Phe His Ser Ser 
            420             


<210>  236
<211>  278
<212>  PRT
<213>  Homo sapiens

<400>  236

Met Glu Arg Leu Val Ile Arg Met Pro Phe Ser His Leu Ser Thr Tyr 
1               5                   10                  15      


Ser Leu Val Trp Val Met Ala Ala Val Val Leu Cys Thr Ala Gln Val 
            20                  25                  30          


Gln Val Val Thr Gln Asp Glu Arg Glu Gln Leu Tyr Thr Pro Ala Ser 
        35                  40                  45              


Leu Lys Cys Ser Leu Gln Asn Ala Gln Glu Ala Leu Ile Val Thr Trp 
    50                  55                  60                  


Gln Lys Lys Lys Ala Val Ser Pro Glu Asn Met Val Thr Phe Ser Glu 
65                  70                  75                  80  


Asn His Gly Val Val Ile Gln Pro Ala Tyr Lys Asp Lys Ile Asn Ile 
                85                  90                  95      


Thr Gln Leu Gly Leu Gln Asn Ser Thr Ile Thr Phe Trp Asn Ile Thr 
            100                 105                 110         


Leu Glu Asp Glu Gly Cys Tyr Met Cys Leu Phe Asn Thr Phe Gly Phe 
        115                 120                 125             


Gly Lys Ile Ser Gly Thr Ala Cys Leu Thr Val Tyr Val Gln Pro Ile 
    130                 135                 140                 


Val Ser Leu His Tyr Lys Phe Ser Glu Asp His Leu Asn Ile Thr Cys 
145                 150                 155                 160 


Ser Ala Thr Ala Arg Pro Ala Pro Met Val Phe Trp Lys Val Pro Arg 
                165                 170                 175     


Ser Gly Ile Glu Asn Ser Thr Val Thr Leu Ser His Pro Asn Gly Thr 
            180                 185                 190         


Thr Ser Val Thr Ser Ile Leu His Ile Lys Asp Pro Lys Asn Gln Val 
        195                 200                 205             


Gly Lys Glu Val Ile Cys Gln Val Leu His Leu Gly Thr Val Thr Asp 
    210                 215                 220                 


Phe Lys Gln Thr Val Asn Lys Gly Tyr Trp Phe Ser Val Pro Leu Leu 
225                 230                 235                 240 


Leu Ser Ile Val Ser Leu Val Ile Leu Leu Val Leu Ile Ser Ile Leu 
                245                 250                 255     


Leu Tyr Trp Lys Arg His Arg Asn Gln Asp Arg Gly Glu Leu Ser Gln 
            260                 265                 270         


Gly Val Gln Lys Met Thr 
        275             


<210>  237
<211>  288
<212>  PRT
<213>  Homo sapiens

<400>  237

Met Gln Ile Pro Gln Ala Pro Trp Pro Val Val Trp Ala Val Leu Gln 
1               5                   10                  15      


Leu Gly Trp Arg Pro Gly Trp Phe Leu Asp Ser Pro Asp Arg Pro Trp 
            20                  25                  30          


Asn Pro Pro Thr Phe Ser Pro Ala Leu Leu Val Val Thr Glu Gly Asp 
        35                  40                  45              


Asn Ala Thr Phe Thr Cys Ser Phe Ser Asn Thr Ser Glu Ser Phe Val 
    50                  55                  60                  


Leu Asn Trp Tyr Arg Met Ser Pro Ser Asn Gln Thr Asp Lys Leu Ala 
65                  70                  75                  80  


Ala Phe Pro Glu Asp Arg Ser Gln Pro Gly Gln Asp Cys Arg Phe Arg 
                85                  90                  95      


Val Thr Gln Leu Pro Asn Gly Arg Asp Phe His Met Ser Val Val Arg 
            100                 105                 110         


Ala Arg Arg Asn Asp Ser Gly Thr Tyr Leu Cys Gly Ala Ile Ser Leu 
        115                 120                 125             


Ala Pro Lys Ala Gln Ile Lys Glu Ser Leu Arg Ala Glu Leu Arg Val 
    130                 135                 140                 


Thr Glu Arg Arg Ala Glu Val Pro Thr Ala His Pro Ser Pro Ser Pro 
145                 150                 155                 160 


Arg Pro Ala Gly Gln Phe Gln Thr Leu Val Val Gly Val Val Gly Gly 
                165                 170                 175     


Leu Leu Gly Ser Leu Val Leu Leu Val Trp Val Leu Ala Val Ile Cys 
            180                 185                 190         


Ser Arg Ala Ala Arg Gly Thr Ile Gly Ala Arg Arg Thr Gly Gln Pro 
        195                 200                 205             


Leu Lys Glu Asp Pro Ser Ala Val Pro Val Phe Ser Val Asp Tyr Gly 
    210                 215                 220                 


Glu Leu Asp Phe Gln Trp Arg Glu Lys Thr Pro Glu Pro Pro Val Pro 
225                 230                 235                 240 


Cys Val Pro Glu Gln Thr Glu Tyr Ala Thr Ile Val Phe Pro Ser Gly 
                245                 250                 255     


Met Gly Thr Ser Ser Pro Ala Arg Arg Gly Ser Ala Asp Gly Pro Arg 
            260                 265                 270         


Ser Ala Gln Pro Leu Arg Pro Glu Asp Gly His Cys Ser Trp Pro Leu 
        275                 280                 285             


<210>  238
<211>  273
<212>  PRT
<213>  Homo sapiens

<400>  238

Met Ile Phe Leu Leu Leu Met Leu Ser Leu Glu Leu Gln Leu His Gln 
1               5                   10                  15      


Ile Ala Ala Leu Phe Thr Val Thr Val Pro Lys Glu Leu Tyr Ile Ile 
            20                  25                  30          


Glu His Gly Ser Asn Val Thr Leu Glu Cys Asn Phe Asp Thr Gly Ser 
        35                  40                  45              


His Val Asn Leu Gly Ala Ile Thr Ala Ser Leu Gln Lys Val Glu Asn 
    50                  55                  60                  


Asp Thr Ser Pro His Arg Glu Arg Ala Thr Leu Leu Glu Glu Gln Leu 
65                  70                  75                  80  


Pro Leu Gly Lys Ala Ser Phe His Ile Pro Gln Val Gln Val Arg Asp 
                85                  90                  95      


Glu Gly Gln Tyr Gln Cys Ile Ile Ile Tyr Gly Val Ala Trp Asp Tyr 
            100                 105                 110         


Lys Tyr Leu Thr Leu Lys Val Lys Ala Ser Tyr Arg Lys Ile Asn Thr 
        115                 120                 125             


His Ile Leu Lys Val Pro Glu Thr Asp Glu Val Glu Leu Thr Cys Gln 
    130                 135                 140                 


Ala Thr Gly Tyr Pro Leu Ala Glu Val Ser Trp Pro Asn Val Ser Val 
145                 150                 155                 160 


Pro Ala Asn Thr Ser His Ser Arg Thr Pro Glu Gly Leu Tyr Gln Val 
                165                 170                 175     


Thr Ser Val Leu Arg Leu Lys Pro Pro Pro Gly Arg Asn Phe Ser Cys 
            180                 185                 190         


Val Phe Trp Asn Thr His Val Arg Glu Leu Thr Leu Ala Ser Ile Asp 
        195                 200                 205             


Leu Gln Ser Gln Met Glu Pro Arg Thr His Pro Thr Trp Leu Leu His 
    210                 215                 220                 


Ile Phe Ile Pro Phe Cys Ile Ile Ala Phe Ile Phe Ile Ala Thr Val 
225                 230                 235                 240 


Ile Ala Leu Arg Lys Gln Leu Cys Gln Lys Leu Tyr Ser Ser Lys Asp 
                245                 250                 255     


Thr Thr Lys Arg Pro Val Thr Thr Thr Lys Arg Glu Val Asn Ser Ala 
            260                 265                 270         


Ile 
    


<210>  239
<211>  290
<212>  PRT
<213>  Homo sapiens

<400>  239

Met Arg Ile Phe Ala Val Phe Ile Phe Met Thr Tyr Trp His Leu Leu 
1               5                   10                  15      


Asn Ala Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Val Val Glu Tyr 
            20                  25                  30          


Gly Ser Asn Met Thr Ile Glu Cys Lys Phe Pro Val Glu Lys Gln Leu 
        35                  40                  45              


Asp Leu Ala Ala Leu Ile Val Tyr Trp Glu Met Glu Asp Lys Asn Ile 
    50                  55                  60                  


Ile Gln Phe Val His Gly Glu Glu Asp Leu Lys Val Gln His Ser Ser 
65                  70                  75                  80  


Tyr Arg Gln Arg Ala Arg Leu Leu Lys Asp Gln Leu Ser Leu Gly Asn 
                85                  90                  95      


Ala Ala Leu Gln Ile Thr Asp Val Lys Leu Gln Asp Ala Gly Val Tyr 
            100                 105                 110         


Arg Cys Met Ile Ser Tyr Gly Gly Ala Asp Tyr Lys Arg Ile Thr Val 
        115                 120                 125             


Lys Val Asn Ala Pro Tyr Asn Lys Ile Asn Gln Arg Ile Leu Val Val 
    130                 135                 140                 


Asp Pro Val Thr Ser Glu His Glu Leu Thr Cys Gln Ala Glu Gly Tyr 
145                 150                 155                 160 


Pro Lys Ala Glu Val Ile Trp Thr Ser Ser Asp His Gln Val Leu Ser 
                165                 170                 175     


Gly Lys Thr Thr Thr Thr Asn Ser Lys Arg Glu Glu Lys Leu Phe Asn 
            180                 185                 190         


Val Thr Ser Thr Leu Arg Ile Asn Thr Thr Thr Asn Glu Ile Phe Tyr 
        195                 200                 205             


Cys Thr Phe Arg Arg Leu Asp Pro Glu Glu Asn His Thr Ala Glu Leu 
    210                 215                 220                 


Val Ile Pro Glu Leu Pro Leu Ala His Pro Pro Asn Glu Arg Thr His 
225                 230                 235                 240 


Leu Val Ile Leu Gly Ala Ile Leu Leu Cys Leu Gly Val Ala Leu Thr 
                245                 250                 255     


Phe Ile Phe Arg Leu Arg Lys Gly Arg Met Met Asp Val Lys Lys Cys 
            260                 265                 270         


Gly Ile Gln Asp Thr Asn Ser Lys Lys Gln Ser Asp Thr His Leu Glu 
        275                 280                 285             


Glu Thr 
    290 


<210>  240
<211>  705
<212>  PRT
<213>  Homo sapiens

<400>  240

Met Arg Pro Ser Gly Thr Ala Gly Ala Ala Leu Leu Ala Leu Leu Ala 
1               5                   10                  15      


Ala Leu Cys Pro Ala Ser Arg Ala Leu Glu Glu Lys Lys Val Cys Gln 
            20                  25                  30          


Gly Thr Ser Asn Lys Leu Thr Gln Leu Gly Thr Phe Glu Asp His Phe 
        35                  40                  45              


Leu Ser Leu Gln Arg Met Phe Asn Asn Cys Glu Val Val Leu Gly Asn 
    50                  55                  60                  


Leu Glu Ile Thr Tyr Val Gln Arg Asn Tyr Asp Leu Ser Phe Leu Lys 
65                  70                  75                  80  


Thr Ile Gln Glu Val Ala Gly Tyr Val Leu Ile Ala Leu Asn Thr Val 
                85                  90                  95      


Glu Arg Ile Pro Leu Glu Asn Leu Gln Ile Ile Arg Gly Asn Met Tyr 
            100                 105                 110         


Tyr Glu Asn Ser Tyr Ala Leu Ala Val Leu Ser Asn Tyr Asp Ala Asn 
        115                 120                 125             


Lys Thr Gly Leu Lys Glu Leu Pro Met Arg Asn Leu Gln Glu Ile Leu 
    130                 135                 140                 


His Gly Ala Val Arg Phe Ser Asn Asn Pro Ala Leu Cys Asn Val Glu 
145                 150                 155                 160 


Ser Ile Gln Trp Arg Asp Ile Val Ser Ser Asp Phe Leu Ser Asn Met 
                165                 170                 175     


Ser Met Asp Phe Gln Asn His Leu Gly Ser Cys Gln Lys Cys Asp Pro 
            180                 185                 190         


Ser Cys Pro Asn Gly Ser Cys Trp Gly Ala Gly Glu Glu Asn Cys Gln 
        195                 200                 205             


Lys Leu Thr Lys Ile Ile Cys Ala Gln Gln Cys Ser Gly Arg Cys Arg 
    210                 215                 220                 


Gly Lys Ser Pro Ser Asp Cys Cys His Asn Gln Cys Ala Ala Gly Cys 
225                 230                 235                 240 


Thr Gly Pro Arg Glu Ser Asp Cys Leu Val Cys Arg Lys Phe Arg Asp 
                245                 250                 255     


Glu Ala Thr Cys Lys Asp Thr Cys Pro Pro Leu Met Leu Tyr Asn Pro 
            260                 265                 270         


Thr Thr Tyr Gln Met Asp Val Asn Pro Glu Gly Lys Tyr Ser Phe Gly 
        275                 280                 285             


Ala Thr Cys Val Lys Lys Cys Pro Arg Asn Tyr Val Val Thr Asp His 
    290                 295                 300                 


Gly Ser Cys Val Arg Ala Cys Gly Ala Asp Ser Tyr Glu Met Glu Glu 
305                 310                 315                 320 


Asp Gly Val Arg Lys Cys Lys Lys Cys Glu Gly Pro Cys Arg Lys Val 
                325                 330                 335     


Cys Asn Gly Ile Gly Ile Gly Glu Phe Lys Asp Ser Leu Ser Ile Asn 
            340                 345                 350         


Ala Thr Asn Ile Lys His Phe Lys Asn Cys Thr Ser Ile Ser Gly Asp 
        355                 360                 365             


Leu His Ile Leu Pro Val Ala Phe Arg Gly Asp Ser Phe Thr His Thr 
    370                 375                 380                 


Pro Pro Leu Asp Pro Gln Glu Leu Asp Ile Leu Lys Thr Val Lys Glu 
385                 390                 395                 400 


Ile Thr Gly Phe Leu Leu Ile Gln Ala Trp Pro Glu Asn Arg Thr Asp 
                405                 410                 415     


Leu His Ala Phe Glu Asn Leu Glu Ile Ile Arg Gly Arg Thr Lys Gln 
            420                 425                 430         


His Gly Gln Phe Ser Leu Ala Val Val Ser Leu Asn Ile Thr Ser Leu 
        435                 440                 445             


Gly Leu Arg Ser Leu Lys Glu Ile Ser Asp Gly Asp Val Ile Ile Ser 
    450                 455                 460                 


Gly Asn Lys Asn Leu Cys Tyr Ala Asn Thr Ile Asn Trp Lys Lys Leu 
465                 470                 475                 480 


Phe Gly Thr Ser Gly Gln Lys Thr Lys Ile Ile Ser Asn Arg Gly Glu 
                485                 490                 495     


Asn Ser Cys Lys Ala Thr Gly Gln Val Cys His Ala Leu Cys Ser Pro 
            500                 505                 510         


Glu Gly Cys Trp Gly Pro Glu Pro Arg Asp Cys Val Ser Cys Arg Asn 
        515                 520                 525             


Val Ser Arg Gly Arg Glu Cys Val Asp Lys Cys Asn Leu Leu Glu Gly 
    530                 535                 540                 


Glu Pro Arg Glu Phe Val Glu Asn Ser Glu Cys Ile Gln Cys His Pro 
545                 550                 555                 560 


Glu Cys Leu Pro Gln Ala Met Asn Ile Thr Cys Thr Gly Arg Gly Pro 
                565                 570                 575     


Asp Asn Cys Ile Gln Cys Ala His Tyr Ile Asp Gly Pro His Cys Val 
            580                 585                 590         


Lys Thr Cys Pro Ala Gly Val Met Gly Glu Asn Asn Thr Leu Val Trp 
        595                 600                 605             


Lys Tyr Ala Asp Ala Gly His Val Cys His Leu Cys His Pro Asn Cys 
    610                 615                 620                 


Thr Tyr Gly Pro Gly Asn Glu Ser Leu Lys Ala Met Leu Phe Cys Leu 
625                 630                 635                 640 


Phe Lys Leu Ser Ser Cys Asn Gln Ser Asn Asp Gly Ser Val Ser His 
                645                 650                 655     


Gln Ser Gly Ser Pro Ala Ala Gln Glu Ser Cys Leu Gly Trp Ile Pro 
            660                 665                 670         


Ser Leu Leu Pro Ser Glu Phe Gln Leu Gly Trp Gly Gly Cys Ser His 
        675                 680                 685             


Leu His Ala Trp Pro Ser Ala Ser Val Ile Ile Thr Ala Ser Ser Cys 
    690                 695                 700                 


His 
705 


<210>  241
<211>  1248
<212>  PRT
<213>  Homo sapiens

<400>  241

Met Val Val Ala Leu Arg Tyr Val Trp Pro Leu Leu Leu Cys Ser Pro 
1               5                   10                  15      


Cys Leu Leu Ile Gln Ile Pro Glu Glu Leu Met Glu Pro Pro Val Ile 
            20                  25                  30          


Thr Glu Gln Ser Pro Arg Arg Leu Val Val Phe Pro Thr Asp Asp Ile 
        35                  40                  45              


Ser Leu Lys Cys Glu Ala Ser Gly Lys Pro Glu Val Gln Phe Arg Trp 
    50                  55                  60                  


Thr Arg Asp Gly Val His Phe Lys Pro Lys Glu Glu Leu Gly Val Thr 
65                  70                  75                  80  


Val Tyr Gln Ser Pro His Ser Gly Ser Phe Thr Ile Thr Gly Asn Asn 
                85                  90                  95      


Ser Asn Phe Ala Gln Arg Phe Gln Gly Ile Tyr Arg Cys Phe Ala Ser 
            100                 105                 110         


Asn Lys Leu Gly Thr Ala Met Ser His Glu Ile Arg Leu Met Ala Glu 
        115                 120                 125             


Gly Ala Pro Lys Trp Pro Lys Glu Thr Val Lys Pro Val Glu Val Glu 
    130                 135                 140                 


Glu Gly Glu Ser Val Val Leu Pro Cys Asn Pro Pro Pro Ser Ala Glu 
145                 150                 155                 160 


Pro Leu Arg Ile Tyr Trp Met Asn Ser Lys Ile Leu His Ile Lys Gln 
                165                 170                 175     


Asp Glu Arg Val Thr Met Gly Gln Asn Gly Asn Leu Tyr Phe Ala Asn 
            180                 185                 190         


Val Leu Thr Ser Asp Asn His Ser Asp Tyr Ile Cys His Ala His Phe 
        195                 200                 205             


Pro Gly Thr Arg Thr Ile Ile Gln Lys Glu Pro Ile Asp Leu Arg Val 
    210                 215                 220                 


Lys Ala Thr Asn Ser Met Ile Asp Arg Lys Pro Arg Leu Leu Phe Pro 
225                 230                 235                 240 


Thr Asn Ser Ser Ser His Leu Val Ala Leu Gln Gly Gln Pro Leu Val 
                245                 250                 255     


Leu Glu Cys Ile Ala Glu Gly Phe Pro Thr Pro Thr Ile Lys Trp Leu 
            260                 265                 270         


Arg Pro Ser Gly Pro Met Pro Ala Asp Arg Val Thr Tyr Gln Asn His 
        275                 280                 285             


Asn Lys Thr Leu Gln Leu Leu Lys Val Gly Glu Glu Asp Asp Gly Glu 
    290                 295                 300                 


Tyr Arg Cys Leu Ala Glu Asn Ser Leu Gly Ser Ala Arg His Ala Tyr 
305                 310                 315                 320 


Tyr Val Thr Val Glu Ala Ala Pro Tyr Trp Leu His Lys Pro Gln Ser 
                325                 330                 335     


His Leu Tyr Gly Pro Gly Glu Thr Ala Arg Leu Asp Cys Gln Val Gln 
            340                 345                 350         


Gly Arg Pro Gln Pro Glu Val Thr Trp Arg Ile Asn Gly Ile Pro Val 
        355                 360                 365             


Glu Glu Leu Ala Lys Asp Gln Lys Tyr Arg Ile Gln Arg Gly Ala Leu 
    370                 375                 380                 


Ile Leu Ser Asn Val Gln Pro Ser Asp Thr Met Val Thr Gln Cys Glu 
385                 390                 395                 400 


Ala Arg Asn Arg His Gly Leu Leu Leu Ala Asn Ala Tyr Ile Tyr Val 
                405                 410                 415     


Val Gln Leu Pro Ala Lys Ile Leu Thr Ala Asp Asn Gln Thr Tyr Met 
            420                 425                 430         


Ala Val Gln Gly Ser Thr Ala Tyr Leu Leu Cys Lys Ala Phe Gly Ala 
        435                 440                 445             


Pro Val Pro Ser Val Gln Trp Leu Asp Glu Asp Gly Thr Thr Val Leu 
    450                 455                 460                 


Gln Asp Glu Arg Phe Phe Pro Tyr Ala Asn Gly Thr Leu Gly Ile Arg 
465                 470                 475                 480 


Asp Leu Gln Ala Asn Asp Thr Gly Arg Tyr Phe Cys Leu Ala Ala Asn 
                485                 490                 495     


Asp Gln Asn Asn Val Thr Ile Met Ala Asn Leu Lys Val Lys Asp Ala 
            500                 505                 510         


Thr Gln Ile Thr Gln Gly Pro Arg Ser Thr Ile Glu Lys Lys Gly Ser 
        515                 520                 525             


Arg Val Thr Phe Thr Cys Gln Ala Ser Phe Asp Pro Ser Leu Gln Pro 
    530                 535                 540                 


Ser Ile Thr Trp Arg Gly Asp Gly Arg Asp Leu Gln Glu Leu Gly Asp 
545                 550                 555                 560 


Ser Asp Lys Tyr Phe Ile Glu Asp Gly Arg Leu Val Ile His Ser Leu 
                565                 570                 575     


Asp Tyr Ser Asp Gln Gly Asn Tyr Ser Cys Val Ala Ser Thr Glu Leu 
            580                 585                 590         


Asp Val Val Glu Ser Arg Ala Gln Leu Leu Val Val Gly Ser Pro Gly 
        595                 600                 605             


Pro Val Pro Arg Leu Val Leu Ser Asp Leu His Leu Leu Thr Gln Ser 
    610                 615                 620                 


Gln Val Arg Val Ser Trp Ser Pro Ala Glu Asp His Asn Ala Pro Ile 
625                 630                 635                 640 


Glu Lys Tyr Asp Ile Glu Phe Glu Asp Lys Glu Met Ala Pro Glu Lys 
                645                 650                 655     


Trp Tyr Ser Leu Gly Lys Val Pro Gly Asn Gln Thr Ser Thr Thr Leu 
            660                 665                 670         


Lys Leu Ser Pro Tyr Val His Tyr Thr Phe Arg Val Thr Ala Ile Asn 
        675                 680                 685             


Lys Tyr Gly Pro Gly Glu Pro Ser Pro Val Ser Glu Thr Val Val Thr 
    690                 695                 700                 


Pro Glu Ala Ala Pro Glu Lys Asn Pro Val Asp Val Lys Gly Glu Gly 
705                 710                 715                 720 


Asn Glu Thr Thr Asn Met Val Ile Thr Trp Lys Pro Leu Arg Trp Met 
                725                 730                 735     


Asp Trp Asn Ala Pro Gln Val Gln Tyr Arg Val Gln Trp Arg Pro Gln 
            740                 745                 750         


Gly Thr Arg Gly Pro Trp Gln Glu Gln Ile Val Ser Asp Pro Phe Leu 
        755                 760                 765             


Val Val Ser Asn Thr Ser Thr Phe Val Pro Tyr Glu Ile Lys Val Gln 
    770                 775                 780                 


Ala Val Asn Ser Gln Gly Lys Gly Pro Glu Pro Gln Val Thr Ile Gly 
785                 790                 795                 800 


Tyr Ser Gly Glu Asp Tyr Pro Gln Ala Ile Pro Glu Leu Glu Gly Ile 
                805                 810                 815     


Glu Ile Leu Asn Ser Ser Ala Val Leu Val Lys Trp Arg Pro Val Asp 
            820                 825                 830         


Leu Ala Gln Val Lys Gly His Leu Arg Gly Tyr Asn Val Thr Tyr Trp 
        835                 840                 845             


Arg Glu Gly Ser Gln Arg Lys His Ser Lys Arg His Ile His Lys Asp 
    850                 855                 860                 


His Val Val Val Pro Ala Asn Thr Thr Ser Val Ile Leu Ser Gly Leu 
865                 870                 875                 880 


Arg Pro Tyr Ser Ser Tyr His Leu Glu Val Gln Ala Phe Asn Gly Arg 
                885                 890                 895     


Gly Ser Gly Pro Ala Ser Glu Phe Thr Phe Ser Thr Pro Glu Gly Val 
            900                 905                 910         


Pro Gly His Pro Glu Ala Leu His Leu Glu Cys Gln Ser Asn Thr Ser 
        915                 920                 925             


Leu Leu Leu Arg Trp Gln Pro Pro Leu Ser His Asn Gly Val Leu Thr 
    930                 935                 940                 


Gly Tyr Val Leu Ser Tyr His Pro Leu Asp Glu Gly Gly Lys Gly Gln 
945                 950                 955                 960 


Leu Ser Phe Asn Leu Arg Asp Pro Glu Leu Arg Thr His Asn Leu Thr 
                965                 970                 975     


Asp Leu Ser Pro His Leu Arg Tyr Arg Phe Gln Leu Gln Ala Thr Thr 
            980                 985                 990         


Lys Glu Gly Pro Gly Glu Ala Ile  Val Arg Glu Gly Gly  Thr Met Ala 
        995                 1000                 1005             


Leu Ser  Gly Ile Ser Asp Phe  Gly Asn Ile Ser Ala  Thr Ala Gly 
    1010                 1015                 1020             


Glu Asn  Tyr Ser Val Val Ser  Trp Val Pro Lys Glu  Gly Gln Cys 
    1025                 1030                 1035             


Asn Phe  Arg Phe His Ile Leu  Phe Lys Ala Leu Gly  Glu Glu Lys 
    1040                 1045                 1050             


Gly Gly  Ala Ser Leu Ser Pro  Gln Tyr Val Ser Tyr  Asn Gln Ser 
    1055                 1060                 1065             


Ser Tyr  Thr Gln Trp Asp Leu  Gln Pro Asp Thr Asp  Tyr Glu Ile 
    1070                 1075                 1080             


His Leu  Phe Lys Glu Arg Met  Phe Arg His Gln Met  Ala Val Lys 
    1085                 1090                 1095             


Thr Asn  Gly Thr Gly Arg Val  Arg Leu Pro Pro Ala  Gly Phe Ala 
    1100                 1105                 1110             


Thr Glu  Gly Trp Phe Ile Gly  Phe Val Ser Ala Ile  Ile Leu Leu 
    1115                 1120                 1125             


Leu Leu  Val Leu Leu Ile Leu  Cys Phe Ile Lys Arg  Ser Lys Gly 
    1130                 1135                 1140             


Gly Lys  Tyr Ser Val Lys Asp  Lys Glu Asp Thr Gln  Val Asp Ser 
    1145                 1150                 1155             


Glu Ala  Arg Pro Met Lys Asp  Glu Thr Phe Gly Glu  Tyr Ser Asp 
    1160                 1165                 1170             


Asn Glu  Glu Lys Ala Phe Gly  Ser Ser Gln Pro Ser  Leu Asn Gly 
    1175                 1180                 1185             


Asp Ile  Lys Pro Leu Gly Ser  Asp Asp Ser Leu Ala  Asp Tyr Gly 
    1190                 1195                 1200             


Gly Ser  Val Asp Val Gln Phe  Asn Glu Asp Gly Ser  Phe Ile Gly 
    1205                 1210                 1215             


Gln Tyr  Ser Gly Lys Lys Glu  Lys Glu Ala Ala Gly  Gly Asn Asp 
    1220                 1225                 1230             


Ser Ser  Gly Ala Thr Ser Pro  Ile Asn Pro Ala Val  Ala Leu Glu 
    1235                 1240                 1245             


<210>  242
<211>  769
<212>  PRT
<213>  Homo sapiens

<400>  242

Met Leu Gly Leu Arg Pro Pro Leu Leu Ala Leu Val Gly Leu Leu Ser 
1               5                   10                  15      


Leu Gly Cys Val Leu Ser Gln Glu Cys Thr Lys Phe Lys Val Ser Ser 
            20                  25                  30          


Cys Arg Glu Cys Ile Glu Ser Gly Pro Gly Cys Thr Trp Cys Gln Lys 
        35                  40                  45              


Leu Asn Phe Thr Gly Pro Gly Asp Pro Asp Ser Ile Arg Cys Asp Thr 
    50                  55                  60                  


Arg Pro Gln Leu Leu Met Arg Gly Cys Ala Ala Asp Asp Ile Met Asp 
65                  70                  75                  80  


Pro Thr Ser Leu Ala Glu Thr Gln Glu Asp His Asn Gly Gly Gln Lys 
                85                  90                  95      


Gln Leu Ser Pro Gln Lys Val Thr Leu Tyr Leu Arg Pro Gly Gln Ala 
            100                 105                 110         


Ala Ala Phe Asn Val Thr Phe Arg Arg Ala Lys Gly Tyr Pro Ile Asp 
        115                 120                 125             


Leu Tyr Tyr Leu Met Asp Leu Ser Tyr Ser Met Leu Asp Asp Leu Arg 
    130                 135                 140                 


Asn Val Lys Lys Leu Gly Gly Asp Leu Leu Arg Ala Leu Asn Glu Ile 
145                 150                 155                 160 


Thr Glu Ser Gly Arg Ile Gly Phe Gly Ser Phe Val Asp Lys Thr Val 
                165                 170                 175     


Leu Pro Phe Val Asn Thr His Pro Asp Lys Leu Arg Asn Pro Cys Pro 
            180                 185                 190         


Asn Lys Glu Lys Glu Cys Gln Pro Pro Phe Ala Phe Arg His Val Leu 
        195                 200                 205             


Lys Leu Thr Asn Asn Ser Asn Gln Phe Gln Thr Glu Val Gly Lys Gln 
    210                 215                 220                 


Leu Ile Ser Gly Asn Leu Asp Ala Pro Glu Gly Gly Leu Asp Ala Met 
225                 230                 235                 240 


Met Gln Val Ala Ala Cys Pro Glu Glu Ile Gly Trp Arg Asn Val Thr 
                245                 250                 255     


Arg Leu Leu Val Phe Ala Thr Asp Asp Gly Phe His Phe Ala Gly Asp 
            260                 265                 270         


Gly Lys Leu Gly Ala Ile Leu Thr Pro Asn Asp Gly Arg Cys His Leu 
        275                 280                 285             


Glu Asp Asn Leu Tyr Lys Arg Ser Asn Glu Phe Asp Tyr Pro Ser Val 
    290                 295                 300                 


Gly Gln Leu Ala His Lys Leu Ala Glu Asn Asn Ile Gln Pro Ile Phe 
305                 310                 315                 320 


Ala Val Thr Ser Arg Met Val Lys Thr Tyr Glu Lys Leu Thr Glu Ile 
                325                 330                 335     


Ile Pro Lys Ser Ala Val Gly Glu Leu Ser Glu Asp Ser Ser Asn Val 
            340                 345                 350         


Val His Leu Ile Lys Asn Ala Tyr Asn Lys Leu Ser Ser Arg Val Phe 
        355                 360                 365             


Leu Asp His Asn Ala Leu Pro Asp Thr Leu Lys Val Thr Tyr Asp Ser 
    370                 375                 380                 


Phe Cys Ser Asn Gly Val Thr His Arg Asn Gln Pro Arg Gly Asp Cys 
385                 390                 395                 400 


Asp Gly Val Gln Ile Asn Val Pro Ile Thr Phe Gln Val Lys Val Thr 
                405                 410                 415     


Ala Thr Glu Cys Ile Gln Glu Gln Ser Phe Val Ile Arg Ala Leu Gly 
            420                 425                 430         


Phe Thr Asp Ile Val Thr Val Gln Val Leu Pro Gln Cys Glu Cys Arg 
        435                 440                 445             


Cys Arg Asp Gln Ser Arg Asp Arg Ser Leu Cys His Gly Lys Gly Phe 
    450                 455                 460                 


Leu Glu Cys Gly Ile Cys Arg Cys Asp Thr Gly Tyr Ile Gly Lys Asn 
465                 470                 475                 480 


Cys Glu Cys Gln Thr Gln Gly Arg Ser Ser Gln Glu Leu Glu Gly Ser 
                485                 490                 495     


Cys Arg Lys Asp Asn Asn Ser Ile Ile Cys Ser Gly Leu Gly Asp Cys 
            500                 505                 510         


Val Cys Gly Gln Cys Leu Cys His Thr Ser Asp Val Pro Gly Lys Leu 
        515                 520                 525             


Ile Tyr Gly Gln Tyr Cys Glu Cys Asp Thr Ile Asn Cys Glu Arg Tyr 
    530                 535                 540                 


Asn Gly Gln Val Cys Gly Gly Pro Gly Arg Gly Leu Cys Phe Cys Gly 
545                 550                 555                 560 


Lys Cys Arg Cys His Pro Gly Phe Glu Gly Ser Ala Cys Gln Cys Glu 
                565                 570                 575     


Arg Thr Thr Glu Gly Cys Leu Asn Pro Arg Arg Val Glu Cys Ser Gly 
            580                 585                 590         


Arg Gly Arg Cys Arg Cys Asn Val Cys Glu Cys His Ser Gly Tyr Gln 
        595                 600                 605             


Leu Pro Leu Cys Gln Glu Cys Pro Gly Cys Pro Ser Pro Cys Gly Lys 
    610                 615                 620                 


Tyr Ile Ser Cys Ala Glu Cys Leu Lys Phe Glu Lys Gly Pro Phe Gly 
625                 630                 635                 640 


Lys Asn Cys Ser Ala Ala Cys Pro Gly Leu Gln Leu Ser Asn Asn Pro 
                645                 650                 655     


Val Lys Gly Arg Thr Cys Lys Glu Arg Asp Ser Glu Gly Cys Trp Val 
            660                 665                 670         


Ala Tyr Thr Leu Glu Gln Gln Asp Gly Met Asp Arg Tyr Leu Ile Tyr 
        675                 680                 685             


Val Asp Glu Ser Arg Glu Cys Val Ala Gly Pro Asn Ile Ala Ala Ile 
    690                 695                 700                 


Val Gly Gly Thr Val Ala Gly Ile Val Leu Ile Gly Ile Leu Leu Leu 
705                 710                 715                 720 


Val Ile Trp Lys Ala Leu Ile His Leu Ser Asp Leu Arg Glu Tyr Arg 
                725                 730                 735     


Arg Phe Glu Lys Glu Lys Leu Lys Ser Gln Trp Asn Asn Asp Asn Pro 
            740                 745                 750         


Leu Phe Lys Ser Ala Thr Thr Thr Val Met Asn Pro Lys Phe Ala Glu 
        755                 760                 765             


Ser 
    


<210>  243
<211>  585
<212>  PRT
<213>  Homo sapiens

<400>  243

Met Thr Pro Pro Arg Leu Phe Trp Val Trp Leu Leu Val Ala Gly Thr 
1               5                   10                  15      


Gln Gly Val Asn Asp Gly Asp Met Arg Leu Ala Asp Gly Gly Ala Thr 
            20                  25                  30          


Asn Gln Gly Arg Val Glu Ile Phe Tyr Arg Gly Gln Trp Gly Thr Val 
        35                  40                  45              


Cys Asp Asn Leu Trp Asp Leu Thr Asp Ala Ser Val Val Cys Arg Ala 
    50                  55                  60                  


Leu Gly Phe Glu Asn Ala Thr Gln Ala Leu Gly Arg Ala Ala Phe Gly 
65                  70                  75                  80  


Gln Gly Ser Gly Pro Ile Met Leu Asp Glu Val Gln Cys Thr Gly Thr 
                85                  90                  95      


Glu Ala Ser Leu Ala Asp Cys Lys Ser Leu Gly Trp Leu Lys Ser Asn 
            100                 105                 110         


Cys Arg His Glu Arg Asp Ala Gly Val Val Cys Thr Asn Glu Thr Arg 
        115                 120                 125             


Ser Thr His Thr Leu Asp Leu Ser Arg Glu Leu Ser Glu Ala Leu Gly 
    130                 135                 140                 


Gln Ile Phe Asp Ser Gln Arg Gly Cys Asp Leu Ser Ile Ser Val Asn 
145                 150                 155                 160 


Val Gln Gly Glu Asp Ala Leu Gly Phe Cys Gly His Thr Val Ile Leu 
                165                 170                 175     


Thr Ala Asn Leu Glu Ala Gln Ala Leu Trp Lys Glu Pro Gly Ser Asn 
            180                 185                 190         


Val Thr Met Ser Val Asp Ala Glu Cys Val Pro Met Val Arg Asp Leu 
        195                 200                 205             


Leu Arg Tyr Phe Tyr Ser Arg Arg Ile Asp Ile Thr Leu Ser Ser Val 
    210                 215                 220                 


Lys Cys Phe His Lys Leu Ala Ser Ala Tyr Gly Ala Arg Gln Leu Gln 
225                 230                 235                 240 


Gly Tyr Cys Ala Ser Leu Phe Ala Ile Leu Leu Pro Gln Asp Pro Ser 
                245                 250                 255     


Phe Gln Met Pro Leu Asp Leu Tyr Ala Tyr Ala Val Ala Thr Gly Asp 
            260                 265                 270         


Ala Leu Leu Glu Lys Leu Cys Leu Gln Phe Leu Ala Trp Asn Phe Glu 
        275                 280                 285             


Ala Leu Thr Gln Ala Glu Ala Trp Pro Ser Val Pro Thr Asp Leu Leu 
    290                 295                 300                 


Gln Leu Leu Leu Pro Arg Ser Asp Leu Ala Val Pro Ser Glu Leu Ala 
305                 310                 315                 320 


Leu Leu Lys Ala Val Asp Thr Trp Ser Trp Gly Glu Arg Ala Ser His 
                325                 330                 335     


Glu Glu Val Glu Gly Leu Val Glu Lys Ile Arg Phe Pro Met Met Leu 
            340                 345                 350         


Pro Glu Glu Leu Phe Glu Leu Gln Phe Asn Leu Ser Leu Tyr Trp Ser 
        355                 360                 365             


His Glu Ala Leu Phe Gln Lys Lys Thr Leu Gln Ala Leu Glu Phe His 
    370                 375                 380                 


Thr Val Pro Phe Gln Leu Leu Ala Arg Tyr Lys Gly Leu Asn Leu Thr 
385                 390                 395                 400 


Glu Asp Thr Tyr Lys Pro Arg Ile Tyr Thr Ser Pro Thr Trp Ser Ala 
                405                 410                 415     


Phe Val Thr Asp Ser Ser Trp Ser Ala Arg Lys Ser Gln Leu Val Tyr 
            420                 425                 430         


Gln Ser Arg Arg Gly Pro Leu Val Lys Tyr Ser Ser Asp Tyr Phe Gln 
        435                 440                 445             


Ala Pro Ser Asp Tyr Arg Tyr Tyr Pro Tyr Gln Ser Phe Gln Thr Pro 
    450                 455                 460                 


Gln His Pro Ser Phe Leu Phe Gln Asp Lys Arg Val Ser Trp Ser Leu 
465                 470                 475                 480 


Val Tyr Leu Pro Thr Ile Gln Ser Cys Trp Asn Tyr Gly Phe Ser Cys 
                485                 490                 495     


Ser Ser Asp Glu Leu Pro Val Leu Gly Leu Thr Lys Ser Gly Gly Ser 
            500                 505                 510         


Asp Arg Thr Ile Ala Tyr Glu Asn Lys Ala Leu Met Leu Cys Glu Gly 
        515                 520                 525             


Leu Phe Val Ala Asp Val Thr Asp Phe Glu Gly Trp Lys Ala Ala Ile 
    530                 535                 540                 


Pro Ser Ala Leu Asp Thr Asn Ser Ser Lys Ser Thr Ser Ser Phe Pro 
545                 550                 555                 560 


Cys Pro Ala Gly His Phe Asn Gly Phe Arg Thr Val Ile Arg Pro Phe 
                565                 570                 575     


Tyr Leu Thr Asn Ser Ser Gly Val Asp 
            580                 585 


<210>  244
<211>  343
<212>  PRT
<213>  Homo sapiens

<400>  244

Met Pro Arg Pro Arg Leu Leu Ala Ala Leu Cys Gly Ala Leu Leu Cys 
1               5                   10                  15      


Ala Pro Ser Leu Leu Val Ala Leu Glu Cys Val Glu Pro Leu Gly Leu 
            20                  25                  30          


Glu Asn Gly Asn Ile Ala Asn Ser Gln Ile Ala Ala Ser Ser Val Arg 
        35                  40                  45              


Val Thr Phe Leu Gly Leu Gln His Trp Val Pro Glu Leu Ala Arg Leu 
    50                  55                  60                  


Asn Arg Ala Gly Met Val Asn Ala Trp Thr Pro Ser Ser Asn Asp Asp 
65                  70                  75                  80  


Asn Pro Trp Ile Gln Val Asn Leu Leu Arg Arg Met Trp Val Thr Gly 
                85                  90                  95      


Val Val Thr Gln Gly Ala Ser Arg Leu Ala Ser His Glu Tyr Leu Lys 
            100                 105                 110         


Ala Phe Lys Val Ala Tyr Ser Leu Asn Gly His Glu Phe Asp Phe Ile 
        115                 120                 125             


His Asp Val Asn Lys Lys His Lys Glu Phe Val Gly Asn Trp Asn Lys 
    130                 135                 140                 


Asn Ala Val His Val Asn Leu Phe Glu Thr Pro Val Glu Ala Gln Tyr 
145                 150                 155                 160 


Val Arg Leu Tyr Pro Thr Ser Cys His Thr Ala Cys Thr Leu Arg Phe 
                165                 170                 175     


Glu Leu Leu Gly Cys Glu Leu Asn Gly Cys Ala Asn Pro Leu Gly Leu 
            180                 185                 190         


Lys Asn Asn Ser Ile Pro Asp Lys Gln Ile Thr Ala Ser Ser Ser Tyr 
        195                 200                 205             


Lys Thr Trp Gly Leu His Leu Phe Ser Trp Asn Pro Ser Tyr Ala Arg 
    210                 215                 220                 


Leu Asp Lys Gln Gly Asn Phe Asn Ala Trp Val Ala Gly Ser Tyr Gly 
225                 230                 235                 240 


Asn Asp Gln Trp Leu Gln Val Asp Leu Gly Ser Ser Lys Glu Val Thr 
                245                 250                 255     


Gly Ile Ile Thr Gln Gly Ala Arg Asn Phe Gly Ser Val Gln Phe Val 
            260                 265                 270         


Ala Ser Tyr Lys Val Ala Tyr Ser Asn Asp Ser Ala Asn Trp Thr Glu 
        275                 280                 285             


Tyr Gln Asp Pro Arg Thr Gly Ser Ser Lys Ile Phe Pro Gly Asn Trp 
    290                 295                 300                 


Asp Asn His Ser His Lys Lys Asn Leu Phe Glu Thr Pro Ile Leu Ala 
305                 310                 315                 320 


Arg Tyr Val Arg Ile Leu Pro Val Ala Trp His Asn Arg Ile Ala Leu 
                325                 330                 335     


Arg Leu Glu Leu Leu Gly Cys 
            340             


<210>  245
<211>  1525
<212>  PRT
<213>  Homo sapiens

<400>  245

Met Arg Gly Val Gly Trp Gln Met Leu Ser Leu Ser Leu Gly Leu Val 
1               5                   10                  15      


Leu Ala Ile Leu Asn Lys Val Ala Pro Gln Ala Cys Pro Ala Gln Cys 
            20                  25                  30          


Ser Cys Ser Gly Ser Thr Val Asp Cys His Gly Leu Ala Leu Arg Ser 
        35                  40                  45              


Val Pro Arg Asn Ile Pro Arg Asn Thr Glu Arg Leu Asp Leu Asn Gly 
    50                  55                  60                  


Asn Asn Ile Thr Arg Ile Thr Lys Thr Asp Phe Ala Gly Leu Arg His 
65                  70                  75                  80  


Leu Arg Val Leu Gln Leu Met Glu Asn Lys Ile Ser Thr Ile Glu Arg 
                85                  90                  95      


Gly Ala Phe Gln Asp Leu Lys Glu Leu Glu Arg Leu Arg Leu Asn Arg 
            100                 105                 110         


Asn His Leu Gln Leu Phe Pro Glu Leu Leu Phe Leu Gly Thr Ala Lys 
        115                 120                 125             


Leu Tyr Arg Leu Asp Leu Ser Glu Asn Gln Ile Gln Ala Ile Pro Arg 
    130                 135                 140                 


Lys Ala Phe Arg Gly Ala Val Asp Ile Lys Asn Leu Gln Leu Asp Tyr 
145                 150                 155                 160 


Asn Gln Ile Ser Cys Ile Glu Asp Gly Ala Phe Arg Ala Leu Arg Asp 
                165                 170                 175     


Leu Glu Val Leu Thr Leu Asn Asn Asn Asn Ile Thr Arg Leu Ser Val 
            180                 185                 190         


Ala Ser Phe Asn His Met Pro Lys Leu Arg Thr Phe Arg Leu His Ser 
        195                 200                 205             


Asn Asn Leu Tyr Cys Asp Cys His Leu Ala Trp Leu Ser Asp Trp Leu 
    210                 215                 220                 


Arg Gln Arg Pro Arg Val Gly Leu Tyr Thr Gln Cys Met Gly Pro Ser 
225                 230                 235                 240 


His Leu Arg Gly His Asn Val Ala Glu Val Gln Lys Arg Glu Phe Val 
                245                 250                 255     


Cys Ser Asp Glu Glu Glu Gly His Gln Ser Phe Met Ala Pro Ser Cys 
            260                 265                 270         


Ser Val Leu His Cys Pro Ala Ala Cys Thr Cys Ser Asn Asn Ile Val 
        275                 280                 285             


Asp Cys Arg Gly Lys Gly Leu Thr Glu Ile Pro Thr Asn Leu Pro Glu 
    290                 295                 300                 


Thr Ile Thr Glu Ile Arg Leu Glu Gln Asn Thr Ile Lys Val Ile Pro 
305                 310                 315                 320 


Pro Gly Ala Phe Ser Pro Tyr Lys Lys Leu Arg Arg Ile Asp Leu Ser 
                325                 330                 335     


Asn Asn Gln Ile Ser Glu Leu Ala Pro Asp Ala Phe Gln Gly Leu Arg 
            340                 345                 350         


Ser Leu Asn Ser Leu Val Leu Tyr Gly Asn Lys Ile Thr Glu Leu Pro 
        355                 360                 365             


Lys Ser Leu Phe Glu Gly Leu Phe Ser Leu Gln Leu Leu Leu Leu Asn 
    370                 375                 380                 


Ala Asn Lys Ile Asn Cys Leu Arg Val Asp Ala Phe Gln Asp Leu His 
385                 390                 395                 400 


Asn Leu Asn Leu Leu Ser Leu Tyr Asp Asn Lys Leu Gln Thr Ile Ala 
                405                 410                 415     


Lys Gly Thr Phe Ser Pro Leu Arg Ala Ile Gln Thr Met His Leu Ala 
            420                 425                 430         


Gln Asn Pro Phe Ile Cys Asp Cys His Leu Lys Trp Leu Ala Asp Tyr 
        435                 440                 445             


Leu His Thr Asn Pro Ile Glu Thr Ser Gly Ala Arg Cys Thr Ser Pro 
    450                 455                 460                 


Arg Arg Leu Ala Asn Lys Arg Ile Gly Gln Ile Lys Ser Lys Lys Phe 
465                 470                 475                 480 


Arg Cys Ser Gly Thr Glu Asp Tyr Arg Ser Lys Leu Ser Gly Asp Cys 
                485                 490                 495     


Phe Ala Asp Leu Ala Cys Pro Glu Lys Cys Arg Cys Glu Gly Thr Thr 
            500                 505                 510         


Val Asp Cys Ser Asn Gln Lys Leu Asn Lys Ile Pro Glu His Ile Pro 
        515                 520                 525             


Gln Tyr Thr Ala Glu Leu Arg Leu Asn Asn Asn Glu Phe Thr Val Leu 
    530                 535                 540                 


Glu Ala Thr Gly Ile Phe Lys Lys Leu Pro Gln Leu Arg Lys Ile Asn 
545                 550                 555                 560 


Phe Ser Asn Asn Lys Ile Thr Asp Ile Glu Glu Gly Ala Phe Glu Gly 
                565                 570                 575     


Ala Ser Gly Val Asn Glu Ile Leu Leu Thr Ser Asn Arg Leu Glu Asn 
            580                 585                 590         


Val Gln His Lys Met Phe Lys Gly Leu Glu Ser Leu Lys Thr Leu Met 
        595                 600                 605             


Leu Arg Ser Asn Arg Ile Thr Cys Val Gly Asn Asp Ser Phe Ile Gly 
    610                 615                 620                 


Leu Ser Ser Val Arg Leu Leu Ser Leu Tyr Asp Asn Gln Ile Thr Thr 
625                 630                 635                 640 


Val Ala Pro Gly Ala Phe Asp Thr Leu His Ser Leu Ser Thr Leu Asn 
                645                 650                 655     


Leu Leu Ala Asn Pro Phe Asn Cys Asn Cys Tyr Leu Ala Trp Leu Gly 
            660                 665                 670         


Glu Trp Leu Arg Lys Lys Arg Ile Val Thr Gly Asn Pro Arg Cys Gln 
        675                 680                 685             


Lys Pro Tyr Phe Leu Lys Glu Ile Pro Ile Gln Asp Val Ala Ile Gln 
    690                 695                 700                 


Asp Phe Thr Cys Asp Asp Gly Asn Asp Asp Asn Ser Cys Ser Pro Leu 
705                 710                 715                 720 


Ser Arg Cys Pro Thr Glu Cys Thr Cys Leu Asp Thr Val Val Arg Cys 
                725                 730                 735     


Ser Asn Lys Gly Leu Lys Val Leu Pro Lys Gly Ile Pro Arg Asp Val 
            740                 745                 750         


Thr Glu Leu Tyr Leu Asp Gly Asn Gln Phe Thr Leu Val Pro Lys Glu 
        755                 760                 765             


Leu Ser Asn Tyr Lys His Leu Thr Leu Ile Asp Leu Ser Asn Asn Arg 
    770                 775                 780                 


Ile Ser Thr Leu Ser Asn Gln Ser Phe Ser Asn Met Thr Gln Leu Leu 
785                 790                 795                 800 


Thr Leu Ile Leu Ser Tyr Asn Arg Leu Arg Cys Ile Pro Pro Arg Thr 
                805                 810                 815     


Phe Asp Gly Leu Lys Ser Leu Arg Leu Leu Ser Leu His Gly Asn Asp 
            820                 825                 830         


Ile Ser Val Val Pro Glu Gly Ala Phe Asn Asp Leu Ser Ala Leu Ser 
        835                 840                 845             


His Leu Ala Ile Gly Ala Asn Pro Leu Tyr Cys Asp Cys Asn Met Gln 
    850                 855                 860                 


Trp Leu Ser Asp Trp Val Lys Ser Glu Tyr Lys Glu Pro Gly Ile Ala 
865                 870                 875                 880 


Arg Cys Ala Gly Pro Gly Glu Met Ala Asp Lys Leu Leu Leu Thr Thr 
                885                 890                 895     


Pro Ser Lys Lys Phe Thr Cys Gln Gly Pro Val Asp Val Asn Ile Leu 
            900                 905                 910         


Ala Lys Cys Asn Pro Cys Leu Ser Asn Pro Cys Lys Asn Asp Gly Thr 
        915                 920                 925             


Cys Asn Ser Asp Pro Val Asp Phe Tyr Arg Cys Thr Cys Pro Tyr Gly 
    930                 935                 940                 


Phe Lys Gly Gln Asp Cys Asp Val Pro Ile His Ala Cys Ile Ser Asn 
945                 950                 955                 960 


Pro Cys Lys His Gly Gly Thr Cys His Leu Lys Glu Gly Glu Glu Asp 
                965                 970                 975     


Gly Phe Trp Cys Ile Cys Ala Asp Gly Phe Glu Gly Glu Asn Cys Glu 
            980                 985                 990         


Val Asn Val Asp Asp Cys Glu Asp  Asn Asp Cys Glu Asn  Asn Ser Thr 
        995                 1000                 1005             


Cys Val  Asp Gly Ile Asn Asn  Tyr Thr Cys Leu Cys  Pro Pro Glu 
    1010                 1015                 1020             


Tyr Thr  Gly Glu Leu Cys Glu  Glu Lys Leu Asp Phe  Cys Ala Gln 
    1025                 1030                 1035             


Asp Leu  Asn Pro Cys Gln His  Asp Ser Lys Cys Ile  Leu Thr Pro 
    1040                 1045                 1050             


Lys Gly  Phe Lys Cys Asp Cys  Thr Pro Gly Tyr Val  Gly Glu His 
    1055                 1060                 1065             


Cys Asp  Ile Asp Phe Asp Asp  Cys Gln Asp Asn Lys  Cys Lys Asn 
    1070                 1075                 1080             


Gly Ala  His Cys Thr Asp Ala  Val Asn Gly Tyr Thr  Cys Ile Cys 
    1085                 1090                 1095             


Pro Glu  Gly Tyr Ser Gly Leu  Phe Cys Glu Phe Ser  Pro Pro Met 
    1100                 1105                 1110             


Val Leu  Pro Arg Thr Ser Pro  Cys Asp Asn Phe Asp  Cys Gln Asn 
    1115                 1120                 1125             


Gly Ala  Gln Cys Ile Val Arg  Ile Asn Glu Pro Ile  Cys Gln Cys 
    1130                 1135                 1140             


Leu Pro  Gly Tyr Gln Gly Glu  Lys Cys Glu Lys Leu  Val Ser Val 
    1145                 1150                 1155             


Asn Phe  Ile Asn Lys Glu Ser  Tyr Leu Gln Ile Pro  Ser Ala Lys 
    1160                 1165                 1170             


Val Arg  Pro Gln Thr Asn Ile  Thr Leu Gln Ile Ala  Thr Asp Glu 
    1175                 1180                 1185             


Asp Ser  Gly Ile Leu Leu Tyr  Lys Gly Asp Lys Asp  His Ile Ala 
    1190                 1195                 1200             


Val Glu  Leu Tyr Arg Gly Arg  Val Arg Ala Ser Tyr  Asp Thr Gly 
    1205                 1210                 1215             


Ser His  Pro Ala Ser Ala Ile  Tyr Ser Val Glu Thr  Ile Asn Asp 
    1220                 1225                 1230             


Gly Asn  Phe His Ile Val Glu  Leu Leu Ala Leu Asp  Gln Ser Leu 
    1235                 1240                 1245             


Ser Leu  Ser Val Asp Gly Gly  Asn Pro Lys Ile Ile  Thr Asn Leu 
    1250                 1255                 1260             


Ser Lys  Gln Ser Thr Leu Asn  Phe Asp Ser Pro Leu  Tyr Val Gly 
    1265                 1270                 1275             


Gly Met  Pro Gly Lys Ser Asn  Val Ala Ser Leu Arg  Gln Ala Pro 
    1280                 1285                 1290             


Gly Gln  Asn Gly Thr Ser Phe  His Gly Cys Ile Arg  Asn Leu Tyr 
    1295                 1300                 1305             


Ile Asn  Ser Glu Leu Gln Asp  Phe Gln Lys Val Pro  Met Gln Thr 
    1310                 1315                 1320             


Gly Ile  Leu Pro Gly Cys Glu  Pro Cys His Lys Lys  Val Cys Ala 
    1325                 1330                 1335             


His Gly  Thr Cys Gln Pro Ser  Ser Gln Ala Gly Phe  Thr Cys Glu 
    1340                 1345                 1350             


Cys Gln  Glu Gly Trp Met Gly  Pro Leu Cys Asp Gln  Arg Thr Asn 
    1355                 1360                 1365             


Asp Pro  Cys Leu Gly Asn Lys  Cys Val His Gly Thr  Cys Leu Pro 
    1370                 1375                 1380             


Ile Asn  Ala Phe Ser Tyr Ser  Cys Lys Cys Leu Glu  Gly His Gly 
    1385                 1390                 1395             


Gly Val  Leu Cys Asp Glu Glu  Glu Asp Leu Phe Asn  Pro Cys Gln 
    1400                 1405                 1410             


Ala Ile  Lys Cys Lys His Gly  Lys Cys Arg Leu Ser  Gly Leu Gly 
    1415                 1420                 1425             


Gln Pro  Tyr Cys Glu Cys Ser  Ser Gly Tyr Thr Gly  Asp Ser Cys 
    1430                 1435                 1440             


Asp Arg  Glu Ile Ser Cys Arg  Gly Glu Arg Ile Arg  Asp Tyr Tyr 
    1445                 1450                 1455             


Gln Lys  Gln Gln Gly Tyr Ala  Ala Cys Gln Thr Thr  Lys Lys Val 
    1460                 1465                 1470             


Ser Arg  Leu Glu Cys Arg Gly  Gly Cys Ala Gly Gly  Gln Cys Cys 
    1475                 1480                 1485             


Gly Pro  Leu Arg Ser Lys Arg  Arg Lys Tyr Ser Phe  Glu Cys Thr 
    1490                 1495                 1500             


Asp Gly  Ser Ser Phe Val Asp  Glu Val Glu Lys Val  Val Lys Cys 
    1505                 1510                 1515             


Gly Cys  Thr Arg Cys Val Ser  
    1520                 1525 


<210>  246
<211>  289
<212>  PRT
<213>  Homo sapiens

<400>  246

Met Lys Asp Arg Leu Glu Gln Leu Lys Ala Lys Gln Leu Thr Gln Asp 
1               5                   10                  15      


Asp Asp Thr Asp Ala Val Glu Ile Ala Ile Asp Asn Thr Ala Phe Met 
            20                  25                  30          


Asp Glu Phe Phe Ser Glu Ile Glu Glu Thr Arg Leu Asn Ile Asp Lys 
        35                  40                  45              


Ile Ser Glu His Val Glu Glu Ala Lys Lys Leu Tyr Ser Ile Ile Leu 
    50                  55                  60                  


Ser Ala Pro Ile Pro Glu Pro Lys Thr Lys Asp Asp Leu Glu Gln Leu 
65                  70                  75                  80  


Thr Thr Glu Ile Lys Lys Arg Ala Asn Asn Val Arg Asn Lys Leu Lys 
                85                  90                  95      


Ser Met Glu Lys His Ile Glu Glu Asp Glu Val Arg Ser Ser Ala Asp 
            100                 105                 110         


Leu Arg Ile Arg Lys Ser Gln His Ser Val Leu Ser Arg Lys Phe Val 
        115                 120                 125             


Glu Val Met Thr Lys Tyr Asn Glu Ala Gln Val Asp Phe Arg Glu Arg 
    130                 135                 140                 


Ser Lys Gly Arg Ile Gln Arg Gln Leu Glu Ile Thr Gly Lys Lys Thr 
145                 150                 155                 160 


Thr Asp Glu Glu Leu Glu Glu Met Leu Glu Ser Gly Asn Pro Ala Ile 
                165                 170                 175     


Phe Thr Ser Gly Ile Ile Asp Ser Gln Ile Ser Lys Gln Ala Leu Ser 
            180                 185                 190         


Glu Ile Glu Gly Arg His Lys Asp Ile Val Arg Leu Glu Ser Ser Ile 
        195                 200                 205             


Lys Glu Leu His Asp Met Phe Met Asp Ile Ala Met Leu Val Glu Asn 
    210                 215                 220                 


Gln Gly Glu Met Leu Asp Asn Ile Glu Leu Asn Val Met His Thr Val 
225                 230                 235                 240 


Asp His Val Glu Lys Ala Arg Asp Glu Thr Lys Lys Ala Val Lys Tyr 
                245                 250                 255     


Gln Ser Gln Ala Arg Lys Lys Leu Ile Ile Ile Ile Val Leu Val Val 
            260                 265                 270         


Val Leu Leu Gly Ile Leu Ala Leu Ile Ile Gly Leu Ser Val Gly Leu 
        275                 280                 285             


Asn 
    


<210>  247
<211>  524
<212>  PRT
<213>  Homo sapiens

<400>  247

Met Cys Pro Arg Ala Ala Arg Ala Pro Ala Thr Leu Leu Leu Ala Leu 
1               5                   10                  15      


Gly Ala Val Leu Trp Pro Ala Ala Gly Ala Trp Glu Leu Thr Ile Leu 
            20                  25                  30          


His Thr Asn Asp Val His Ser Arg Leu Glu Gln Thr Ser Glu Asp Ser 
        35                  40                  45              


Ser Lys Cys Val Asn Ala Ser Arg Cys Met Gly Gly Val Ala Arg Leu 
    50                  55                  60                  


Phe Thr Lys Val Gln Gln Ile Arg Arg Ala Glu Pro Asn Val Leu Leu 
65                  70                  75                  80  


Leu Asp Ala Gly Asp Gln Tyr Gln Gly Thr Ile Trp Phe Thr Val Tyr 
                85                  90                  95      


Lys Gly Ala Glu Val Ala His Phe Met Asn Ala Leu Arg Tyr Asp Ala 
            100                 105                 110         


Met Ala Leu Gly Asn His Glu Phe Asp Asn Gly Val Glu Gly Leu Ile 
        115                 120                 125             


Glu Pro Leu Leu Lys Glu Ala Lys Phe Pro Ile Leu Ser Ala Asn Ile 
    130                 135                 140                 


Lys Ala Lys Gly Pro Leu Ala Ser Gln Ile Ser Gly Leu Tyr Leu Pro 
145                 150                 155                 160 


Tyr Lys Val Leu Pro Val Gly Asp Glu Val Val Gly Ile Val Gly Tyr 
                165                 170                 175     


Thr Ser Lys Glu Thr Pro Phe Leu Ser Asn Pro Gly Thr Asn Leu Val 
            180                 185                 190         


Phe Glu Asp Glu Ile Thr Ala Leu Gln Pro Glu Val Asp Lys Leu Lys 
        195                 200                 205             


Thr Leu Asn Val Asn Lys Ile Ile Ala Leu Gly His Ser Gly Phe Glu 
    210                 215                 220                 


Met Asp Lys Leu Ile Ala Gln Lys Val Arg Gly Val Asp Val Val Val 
225                 230                 235                 240 


Gly Gly His Ser Asn Thr Phe Leu Tyr Thr Gly Asn Pro Pro Ser Lys 
                245                 250                 255     


Glu Val Pro Ala Gly Lys Tyr Pro Phe Ile Val Thr Ser Asp Asp Gly 
            260                 265                 270         


Arg Lys Val Pro Val Val Gln Ala Tyr Ala Phe Gly Lys Tyr Leu Gly 
        275                 280                 285             


Tyr Leu Lys Ile Glu Phe Asp Glu Arg Gly Asn Val Ile Ser Ser His 
    290                 295                 300                 


Gly Asn Pro Ile Leu Leu Asn Ser Ser Ile Pro Glu Asp Pro Ser Ile 
305                 310                 315                 320 


Lys Ala Asp Ile Asn Lys Trp Arg Ile Lys Leu Asp Asn Tyr Ser Thr 
                325                 330                 335     


Gln Glu Leu Gly Lys Thr Ile Val Tyr Leu Asp Gly Ser Ser Gln Ser 
            340                 345                 350         


Cys Arg Phe Arg Glu Cys Asn Met Gly Asn Leu Ile Cys Asp Ala Met 
        355                 360                 365             


Ile Asn Asn Asn Leu Arg His Thr Asp Glu Met Phe Trp Asn His Val 
    370                 375                 380                 


Ser Met Cys Ile Leu Asn Gly Gly Gly Ile Arg Ser Pro Ile Asp Glu 
385                 390                 395                 400 


Arg Asn Asn Gly Ile His Val Val Tyr Asp Leu Ser Arg Lys Pro Gly 
                405                 410                 415     


Asp Arg Val Val Lys Leu Asp Val Leu Cys Thr Lys Cys Arg Val Pro 
            420                 425                 430         


Ser Tyr Asp Pro Leu Lys Met Asp Glu Val Tyr Lys Val Ile Leu Pro 
        435                 440                 445             


Asn Phe Leu Ala Asn Gly Gly Asp Gly Phe Gln Met Ile Lys Asp Glu 
    450                 455                 460                 


Leu Leu Arg His Asp Ser Gly Asp Gln Asp Ile Asn Val Val Ser Thr 
465                 470                 475                 480 


Tyr Ile Ser Lys Met Lys Val Ile Tyr Pro Ala Val Glu Gly Arg Ile 
                485                 490                 495     


Lys Phe Ser Thr Gly Ser His Cys His Gly Ser Phe Ser Leu Ile Phe 
            500                 505                 510         


Leu Ser Leu Trp Ala Val Ile Phe Val Leu Tyr Gln 
        515                 520                 


<210>  248
<211>  161
<212>  PRT
<213>  Homo sapiens

<400>  248

Met Asn Leu Ala Ile Ser Ile Ala Leu Leu Leu Thr Val Leu Gln Val 
1               5                   10                  15      


Ser Arg Gly Gln Lys Val Thr Ser Leu Thr Ala Cys Leu Val Asp Gln 
            20                  25                  30          


Ser Leu Arg Leu Asp Cys Arg His Glu Asn Thr Ser Ser Ser Pro Ile 
        35                  40                  45              


Gln Tyr Glu Phe Ser Leu Thr Arg Glu Thr Lys Lys His Val Leu Phe 
    50                  55                  60                  


Gly Thr Val Gly Val Pro Glu His Thr Tyr Arg Ser Arg Thr Asn Phe 
65                  70                  75                  80  


Thr Ser Lys Tyr Asn Met Lys Val Leu Tyr Leu Ser Ala Phe Thr Ser 
                85                  90                  95      


Lys Asp Glu Gly Thr Tyr Thr Cys Ala Leu His His Ser Gly His Ser 
            100                 105                 110         


Pro Pro Ile Ser Ser Gln Asn Val Thr Val Leu Arg Asp Lys Leu Val 
        115                 120                 125             


Lys Cys Glu Gly Ile Ser Leu Leu Ala Gln Asn Thr Ser Trp Leu Leu 
    130                 135                 140                 


Leu Leu Leu Leu Ser Leu Ser Leu Leu Gln Ala Thr Asp Phe Met Ser 
145                 150                 155                 160 


Leu 
    


<210>  249
<211>  798
<212>  PRT
<213>  Homo sapiens

<400>  249

Met Asn Leu Gln Pro Ile Phe Trp Ile Gly Leu Ile Ser Ser Val Cys 
1               5                   10                  15      


Cys Val Phe Ala Gln Thr Asp Glu Asn Arg Cys Leu Lys Ala Asn Ala 
            20                  25                  30          


Lys Ser Cys Gly Glu Cys Ile Gln Ala Gly Pro Asn Cys Gly Trp Cys 
        35                  40                  45              


Thr Asn Ser Thr Phe Leu Gln Glu Gly Met Pro Thr Ser Ala Arg Cys 
    50                  55                  60                  


Asp Asp Leu Glu Ala Leu Lys Lys Lys Gly Cys Pro Pro Asp Asp Ile 
65                  70                  75                  80  


Glu Asn Pro Arg Gly Ser Lys Asp Ile Lys Lys Asn Lys Asn Val Thr 
                85                  90                  95      


Asn Arg Ser Lys Gly Thr Ala Glu Lys Leu Lys Pro Glu Asp Ile Thr 
            100                 105                 110         


Gln Ile Gln Pro Gln Gln Leu Val Leu Arg Leu Arg Ser Gly Glu Pro 
        115                 120                 125             


Gln Thr Phe Thr Leu Lys Phe Lys Arg Ala Glu Asp Tyr Pro Ile Asp 
    130                 135                 140                 


Leu Tyr Tyr Leu Met Asp Leu Ser Tyr Ser Met Lys Asp Asp Leu Glu 
145                 150                 155                 160 


Asn Val Lys Ser Leu Gly Thr Asp Leu Met Asn Glu Met Arg Arg Ile 
                165                 170                 175     


Thr Ser Asp Phe Arg Ile Gly Phe Gly Ser Phe Val Glu Lys Thr Val 
            180                 185                 190         


Met Pro Tyr Ile Ser Thr Thr Pro Ala Lys Leu Arg Asn Pro Cys Thr 
        195                 200                 205             


Ser Glu Gln Asn Cys Thr Ser Pro Phe Ser Tyr Lys Asn Val Leu Ser 
    210                 215                 220                 


Leu Thr Asn Lys Gly Glu Val Phe Asn Glu Leu Val Gly Lys Gln Arg 
225                 230                 235                 240 


Ile Ser Gly Asn Leu Asp Ser Pro Glu Gly Gly Phe Asp Ala Ile Met 
                245                 250                 255     


Gln Val Ala Val Cys Gly Ser Leu Ile Gly Trp Arg Asn Val Thr Arg 
            260                 265                 270         


Leu Leu Val Phe Ser Thr Asp Ala Gly Phe His Phe Ala Gly Asp Gly 
        275                 280                 285             


Lys Leu Gly Gly Ile Val Leu Pro Asn Asp Gly Gln Cys His Leu Glu 
    290                 295                 300                 


Asn Asn Met Tyr Thr Met Ser His Tyr Tyr Asp Tyr Pro Ser Ile Ala 
305                 310                 315                 320 


His Leu Val Gln Lys Leu Ser Glu Asn Asn Ile Gln Thr Ile Phe Ala 
                325                 330                 335     


Val Thr Glu Glu Phe Gln Pro Val Tyr Lys Glu Leu Lys Asn Leu Ile 
            340                 345                 350         


Pro Lys Ser Ala Val Gly Thr Leu Ser Ala Asn Ser Ser Asn Val Ile 
        355                 360                 365             


Gln Leu Ile Ile Asp Ala Tyr Asn Ser Leu Ser Ser Glu Val Ile Leu 
    370                 375                 380                 


Glu Asn Gly Lys Leu Ser Glu Gly Val Thr Ile Ser Tyr Lys Ser Tyr 
385                 390                 395                 400 


Cys Lys Asn Gly Val Asn Gly Thr Gly Glu Asn Gly Arg Lys Cys Ser 
                405                 410                 415     


Asn Ile Ser Ile Gly Asp Glu Val Gln Phe Glu Ile Ser Ile Thr Ser 
            420                 425                 430         


Asn Lys Cys Pro Lys Lys Asp Ser Asp Ser Phe Lys Ile Arg Pro Leu 
        435                 440                 445             


Gly Phe Thr Glu Glu Val Glu Val Ile Leu Gln Tyr Ile Cys Glu Cys 
    450                 455                 460                 


Glu Cys Gln Ser Glu Gly Ile Pro Glu Ser Pro Lys Cys His Glu Gly 
465                 470                 475                 480 


Asn Gly Thr Phe Glu Cys Gly Ala Cys Arg Cys Asn Glu Gly Arg Val 
                485                 490                 495     


Gly Arg His Cys Glu Cys Ser Thr Asp Glu Val Asn Ser Glu Asp Met 
            500                 505                 510         


Asp Ala Tyr Cys Arg Lys Glu Asn Ser Ser Glu Ile Cys Ser Asn Asn 
        515                 520                 525             


Gly Glu Cys Val Cys Gly Gln Cys Val Cys Arg Lys Arg Asp Asn Thr 
    530                 535                 540                 


Asn Glu Ile Tyr Ser Gly Lys Phe Cys Glu Cys Asp Asn Phe Asn Cys 
545                 550                 555                 560 


Asp Arg Ser Asn Gly Leu Ile Cys Gly Gly Asn Gly Val Cys Lys Cys 
                565                 570                 575     


Arg Val Cys Glu Cys Asn Pro Asn Tyr Thr Gly Ser Ala Cys Asp Cys 
            580                 585                 590         


Ser Leu Asp Thr Ser Thr Cys Glu Ala Ser Asn Gly Gln Ile Cys Asn 
        595                 600                 605             


Gly Arg Gly Ile Cys Glu Cys Gly Val Cys Lys Cys Thr Asp Pro Lys 
    610                 615                 620                 


Phe Gln Gly Gln Thr Cys Glu Met Cys Gln Thr Cys Leu Gly Val Cys 
625                 630                 635                 640 


Ala Glu His Lys Glu Cys Val Gln Cys Arg Ala Phe Asn Lys Gly Glu 
                645                 650                 655     


Lys Lys Asp Thr Cys Thr Gln Glu Cys Ser Tyr Phe Asn Ile Thr Lys 
            660                 665                 670         


Val Glu Ser Arg Asp Lys Leu Pro Gln Pro Val Gln Pro Asp Pro Val 
        675                 680                 685             


Ser His Cys Lys Glu Lys Asp Val Asp Asp Cys Trp Phe Tyr Phe Thr 
    690                 695                 700                 


Tyr Ser Val Asn Gly Asn Asn Glu Val Met Val His Val Val Glu Asn 
705                 710                 715                 720 


Pro Glu Cys Pro Thr Gly Pro Asp Ile Ile Pro Ile Val Ala Gly Val 
                725                 730                 735     


Val Ala Gly Ile Val Leu Ile Gly Leu Ala Leu Leu Leu Ile Trp Lys 
            740                 745                 750         


Leu Leu Met Ile Ile His Asp Arg Arg Glu Phe Ala Lys Phe Glu Lys 
        755                 760                 765             


Glu Lys Met Asn Ala Lys Trp Asp Thr Gly Glu Asn Pro Ile Tyr Lys 
    770                 775                 780                 


Ser Ala Val Thr Thr Val Val Asn Pro Lys Tyr Glu Gly Lys 
785                 790                 795             


<210>  250
<211>  476
<212>  PRT
<213>  Homo sapiens

<400>  250

Met Leu Glu Ala Ser Gln Asp Met Gly Arg Thr Leu Glu Trp Arg Pro 
1               5                   10                  15      


Arg Thr Pro Ala Leu Val Arg Gly Cys His Leu Glu Gly Val Ala Gly 
            20                  25                  30          


His Lys Glu Ala His Ile Leu Arg Val Leu Pro Gly His Ser Ala Gly 
        35                  40                  45              


Pro Arg Thr Val Thr Val Lys Val Glu Leu Ser Cys Ala Pro Gly Asp 
    50                  55                  60                  


Leu Asp Ala Val Leu Ile Leu Gln Gly Pro Pro Tyr Val Ser Trp Leu 
65                  70                  75                  80  


Ile Asp Ala Asn His Asn Met Gln Ile Trp Thr Thr Gly Glu Tyr Ser 
                85                  90                  95      


Phe Lys Ile Phe Pro Glu Lys Asn Ile Arg Gly Phe Lys Leu Pro Asp 
            100                 105                 110         


Thr Pro Gln Gly Leu Leu Gly Glu Ala Arg Met Leu Asn Ala Ser Ile 
        115                 120                 125             


Val Ala Ser Phe Val Glu Leu Pro Leu Ala Ser Ile Val Ser Leu His 
    130                 135                 140                 


Ala Ser Ser Cys Gly Gly Arg Leu Gln Thr Ser Pro Ala Pro Ile Gln 
145                 150                 155                 160 


Thr Thr Pro Pro Lys Asp Thr Cys Ser Pro Glu Leu Leu Met Ser Leu 
                165                 170                 175     


Ile Gln Thr Lys Cys Ala Asp Asp Ala Met Thr Leu Val Leu Lys Lys 
            180                 185                 190         


Glu Leu Val Ala His Leu Lys Cys Thr Ile Thr Gly Leu Thr Phe Trp 
        195                 200                 205             


Asp Pro Ser Cys Glu Ala Glu Asp Arg Gly Asp Lys Phe Val Leu Arg 
    210                 215                 220                 


Ser Ala Tyr Ser Ser Cys Gly Met Gln Val Ser Ala Ser Met Ile Ser 
225                 230                 235                 240 


Asn Glu Ala Val Val Asn Ile Leu Ser Ser Ser Ser Pro Gln Arg Lys 
                245                 250                 255     


Lys Val His Cys Leu Asn Met Asp Ser Leu Ser Phe Gln Leu Gly Leu 
            260                 265                 270         


Tyr Leu Ser Pro His Phe Leu Gln Ala Ser Asn Thr Ile Glu Pro Gly 
        275                 280                 285             


Gln Gln Ser Phe Val Gln Val Arg Val Ser Pro Ser Val Ser Glu Phe 
    290                 295                 300                 


Leu Leu Gln Leu Asp Ser Cys His Leu Asp Leu Gly Pro Glu Gly Gly 
305                 310                 315                 320 


Thr Val Glu Leu Ile Gln Gly Arg Ala Ala Lys Gly Asn Cys Val Ser 
                325                 330                 335     


Leu Leu Ser Pro Ser Pro Glu Gly Asp Pro Arg Phe Ser Phe Leu Leu 
            340                 345                 350         


His Phe Tyr Thr Val Pro Ile Pro Lys Thr Gly Thr Leu Ser Cys Thr 
        355                 360                 365             


Val Ala Leu Arg Pro Lys Thr Gly Ser Gln Asp Gln Glu Val His Arg 
    370                 375                 380                 


Thr Val Phe Met Arg Leu Asn Ile Ile Ser Pro Asp Leu Ser Gly Cys 
385                 390                 395                 400 


Thr Ser Lys Gly Leu Val Leu Pro Ala Val Leu Gly Ile Thr Phe Gly 
                405                 410                 415     


Ala Phe Leu Ile Gly Ala Leu Leu Thr Ala Ala Leu Trp Tyr Ile Tyr 
            420                 425                 430         


Ser His Thr Arg Ser Pro Ser Lys Arg Glu Pro Val Val Ala Val Ala 
        435                 440                 445             


Ala Pro Ala Ser Ser Glu Ser Ser Ser Thr Asn His Ser Ile Gly Ser 
    450                 455                 460                 


Thr Gln Ser Thr Pro Cys Ser Thr Ser Ser Met Ala 
465                 470                 475     


<210>  251
<211>  739
<212>  PRT
<213>  Homo sapiens

<400>  251

Met Pro Gly Lys Met Val Val Ile Leu Gly Ala Ser Asn Ile Leu Trp 
1               5                   10                  15      


Ile Met Phe Ala Ala Ser Gln Ala Phe Lys Ile Glu Thr Thr Pro Glu 
            20                  25                  30          


Ser Arg Tyr Leu Ala Gln Ile Gly Asp Ser Val Ser Leu Thr Cys Ser 
        35                  40                  45              


Thr Thr Gly Cys Glu Ser Pro Phe Phe Ser Trp Arg Thr Gln Ile Asp 
    50                  55                  60                  


Ser Pro Leu Asn Gly Lys Val Thr Asn Glu Gly Thr Thr Ser Thr Leu 
65                  70                  75                  80  


Thr Met Asn Pro Val Ser Phe Gly Asn Glu His Ser Tyr Leu Cys Thr 
                85                  90                  95      


Ala Thr Cys Glu Ser Arg Lys Leu Glu Lys Gly Ile Gln Val Glu Ile 
            100                 105                 110         


Tyr Ser Phe Pro Lys Asp Pro Glu Ile His Leu Ser Gly Pro Leu Glu 
        115                 120                 125             


Ala Gly Lys Pro Ile Thr Val Lys Cys Ser Val Ala Asp Val Tyr Pro 
    130                 135                 140                 


Phe Asp Arg Leu Glu Ile Asp Leu Leu Lys Gly Asp His Leu Met Lys 
145                 150                 155                 160 


Ser Gln Glu Phe Leu Glu Asp Ala Asp Arg Lys Ser Leu Glu Thr Lys 
                165                 170                 175     


Ser Leu Glu Val Thr Phe Thr Pro Val Ile Glu Asp Ile Gly Lys Val 
            180                 185                 190         


Leu Val Cys Arg Ala Lys Leu His Ile Asp Glu Met Asp Ser Val Pro 
        195                 200                 205             


Thr Val Arg Gln Ala Val Lys Glu Leu Gln Val Tyr Ile Ser Pro Lys 
    210                 215                 220                 


Asn Thr Val Ile Ser Val Asn Pro Ser Thr Lys Leu Gln Glu Gly Gly 
225                 230                 235                 240 


Ser Val Thr Met Thr Cys Ser Ser Glu Gly Leu Pro Ala Pro Glu Ile 
                245                 250                 255     


Phe Trp Ser Lys Lys Leu Asp Asn Gly Asn Leu Gln His Leu Ser Gly 
            260                 265                 270         


Asn Ala Thr Leu Thr Leu Ile Ala Met Arg Met Glu Asp Ser Gly Ile 
        275                 280                 285             


Tyr Val Cys Glu Gly Val Asn Leu Ile Gly Lys Asn Arg Lys Glu Val 
    290                 295                 300                 


Glu Leu Ile Val Gln Glu Lys Pro Phe Thr Val Glu Ile Ser Pro Gly 
305                 310                 315                 320 


Pro Arg Ile Ala Ala Gln Ile Gly Asp Ser Val Met Leu Thr Cys Ser 
                325                 330                 335     


Val Met Gly Cys Glu Ser Pro Ser Phe Ser Trp Arg Thr Gln Ile Asp 
            340                 345                 350         


Ser Pro Leu Ser Gly Lys Val Arg Ser Glu Gly Thr Asn Ser Thr Leu 
        355                 360                 365             


Thr Leu Ser Pro Val Ser Phe Glu Asn Glu His Ser Tyr Leu Cys Thr 
    370                 375                 380                 


Val Thr Cys Gly His Lys Lys Leu Glu Lys Gly Ile Gln Val Glu Leu 
385                 390                 395                 400 


Tyr Ser Phe Pro Arg Asp Pro Glu Ile Glu Met Ser Gly Gly Leu Val 
                405                 410                 415     


Asn Gly Ser Ser Val Thr Val Ser Cys Lys Val Pro Ser Val Tyr Pro 
            420                 425                 430         


Leu Asp Arg Leu Glu Ile Glu Leu Leu Lys Gly Glu Thr Ile Leu Glu 
        435                 440                 445             


Asn Ile Glu Phe Leu Glu Asp Thr Asp Met Lys Ser Leu Glu Asn Lys 
    450                 455                 460                 


Ser Leu Glu Met Thr Phe Ile Pro Thr Ile Glu Asp Thr Gly Lys Ala 
465                 470                 475                 480 


Leu Val Cys Gln Ala Lys Leu His Ile Asp Asp Met Glu Phe Glu Pro 
                485                 490                 495     


Lys Gln Arg Gln Ser Thr Gln Thr Leu Tyr Val Asn Val Ala Pro Arg 
            500                 505                 510         


Asp Thr Thr Val Leu Val Ser Pro Ser Ser Ile Leu Glu Glu Gly Ser 
        515                 520                 525             


Ser Val Asn Met Thr Cys Leu Ser Gln Gly Phe Pro Ala Pro Lys Ile 
    530                 535                 540                 


Leu Trp Ser Arg Gln Leu Pro Asn Gly Glu Leu Gln Pro Leu Ser Glu 
545                 550                 555                 560 


Asn Ala Thr Leu Thr Leu Ile Ser Thr Lys Met Glu Asp Ser Gly Val 
                565                 570                 575     


Tyr Leu Cys Glu Gly Ile Asn Gln Ala Gly Arg Ser Arg Lys Glu Val 
            580                 585                 590         


Glu Leu Ile Ile Gln Val Thr Pro Lys Asp Ile Lys Leu Thr Ala Phe 
        595                 600                 605             


Pro Ser Glu Ser Val Lys Glu Gly Asp Thr Val Ile Ile Ser Cys Thr 
    610                 615                 620                 


Cys Gly Asn Val Pro Glu Thr Trp Ile Ile Leu Lys Lys Lys Ala Glu 
625                 630                 635                 640 


Thr Gly Asp Thr Val Leu Lys Ser Ile Asp Gly Ala Tyr Thr Ile Arg 
                645                 650                 655     


Lys Ala Gln Leu Lys Asp Ala Gly Val Tyr Glu Cys Glu Ser Lys Asn 
            660                 665                 670         


Lys Val Gly Ser Gln Leu Arg Ser Leu Thr Leu Asp Val Gln Gly Arg 
        675                 680                 685             


Glu Asn Asn Lys Asp Tyr Phe Ser Pro Glu Leu Leu Val Leu Tyr Phe 
    690                 695                 700                 


Ala Ser Ser Leu Ile Ile Pro Ala Ile Gly Met Ile Ile Tyr Phe Ala 
705                 710                 715                 720 


Arg Lys Ala Asn Met Lys Gly Ser Tyr Ser Leu Val Glu Ala Gln Lys 
                725                 730                 735     


Ser Lys Val 
            


<210>  252
<211>  646
<212>  PRT
<213>  Homo sapiens

<400>  252

Met Gly Leu Pro Arg Leu Val Cys Ala Phe Leu Leu Ala Ala Cys Cys 
1               5                   10                  15      


Cys Cys Pro Arg Val Ala Gly Val Pro Gly Glu Ala Glu Gln Pro Ala 
            20                  25                  30          


Pro Glu Leu Val Glu Val Glu Val Gly Ser Thr Ala Leu Leu Lys Cys 
        35                  40                  45              


Gly Leu Ser Gln Ser Gln Gly Asn Leu Ser His Val Asp Trp Phe Ser 
    50                  55                  60                  


Val His Lys Glu Lys Arg Thr Leu Ile Phe Arg Val Arg Gln Gly Gln 
65                  70                  75                  80  


Gly Gln Ser Glu Pro Gly Glu Tyr Glu Gln Arg Leu Ser Leu Gln Asp 
                85                  90                  95      


Arg Gly Ala Thr Leu Ala Leu Thr Gln Val Thr Pro Gln Asp Glu Arg 
            100                 105                 110         


Ile Phe Leu Cys Gln Gly Lys Arg Pro Arg Ser Gln Glu Tyr Arg Ile 
        115                 120                 125             


Gln Leu Arg Val Tyr Lys Ala Pro Glu Glu Pro Asn Ile Gln Val Asn 
    130                 135                 140                 


Pro Leu Gly Ile Pro Val Asn Ser Lys Glu Pro Glu Glu Val Ala Thr 
145                 150                 155                 160 


Cys Val Gly Arg Asn Gly Tyr Pro Ile Pro Gln Val Ile Trp Tyr Lys 
                165                 170                 175     


Asn Gly Arg Pro Leu Lys Glu Glu Lys Asn Arg Val His Ile Gln Ser 
            180                 185                 190         


Ser Gln Thr Val Glu Ser Ser Gly Leu Tyr Thr Leu Gln Ser Ile Leu 
        195                 200                 205             


Lys Ala Gln Leu Val Lys Glu Asp Lys Asp Ala Gln Phe Tyr Cys Glu 
    210                 215                 220                 


Leu Asn Tyr Arg Leu Pro Ser Gly Asn His Met Lys Glu Ser Arg Glu 
225                 230                 235                 240 


Val Thr Val Pro Val Phe Tyr Pro Thr Glu Lys Val Trp Leu Glu Val 
                245                 250                 255     


Glu Pro Val Gly Met Leu Lys Glu Gly Asp Arg Val Glu Ile Arg Cys 
            260                 265                 270         


Leu Ala Asp Gly Asn Pro Pro Pro His Phe Ser Ile Ser Lys Gln Asn 
        275                 280                 285             


Pro Ser Thr Arg Glu Ala Glu Glu Glu Thr Thr Asn Asp Asn Gly Val 
    290                 295                 300                 


Leu Val Leu Glu Pro Ala Arg Lys Glu His Ser Gly Arg Tyr Glu Cys 
305                 310                 315                 320 


Gln Gly Leu Asp Leu Asp Thr Met Ile Ser Leu Leu Ser Glu Pro Gln 
                325                 330                 335     


Glu Leu Leu Val Asn Tyr Val Ser Asp Val Arg Val Ser Pro Ala Ala 
            340                 345                 350         


Pro Glu Arg Gln Glu Gly Ser Ser Leu Thr Leu Thr Cys Glu Ala Glu 
        355                 360                 365             


Ser Ser Gln Asp Leu Glu Phe Gln Trp Leu Arg Glu Glu Thr Gly Gln 
    370                 375                 380                 


Val Leu Glu Arg Gly Pro Val Leu Gln Leu His Asp Leu Lys Arg Glu 
385                 390                 395                 400 


Ala Gly Gly Gly Tyr Arg Cys Val Ala Ser Val Pro Ser Ile Pro Gly 
                405                 410                 415     


Leu Asn Arg Thr Gln Leu Val Asn Val Ala Ile Phe Gly Pro Pro Trp 
            420                 425                 430         


Met Ala Phe Lys Glu Arg Lys Val Trp Val Lys Glu Asn Met Val Leu 
        435                 440                 445             


Asn Leu Ser Cys Glu Ala Ser Gly His Pro Arg Pro Thr Ile Ser Trp 
    450                 455                 460                 


Asn Val Asn Gly Thr Ala Ser Glu Gln Asp Gln Asp Pro Gln Arg Val 
465                 470                 475                 480 


Leu Ser Thr Leu Asn Val Leu Val Thr Pro Glu Leu Leu Glu Thr Gly 
                485                 490                 495     


Val Glu Cys Thr Ala Ser Asn Asp Leu Gly Lys Asn Thr Ser Ile Leu 
            500                 505                 510         


Phe Leu Glu Leu Val Asn Leu Thr Thr Leu Thr Pro Asp Ser Asn Thr 
        515                 520                 525             


Thr Thr Gly Leu Ser Thr Ser Thr Ala Ser Pro His Thr Arg Ala Asn 
    530                 535                 540                 


Ser Thr Ser Thr Glu Arg Lys Leu Pro Glu Pro Glu Ser Arg Gly Val 
545                 550                 555                 560 


Val Ile Val Ala Val Ile Val Cys Ile Leu Val Leu Ala Val Leu Gly 
                565                 570                 575     


Ala Val Leu Tyr Phe Leu Tyr Lys Lys Gly Lys Leu Pro Cys Arg Arg 
            580                 585                 590         


Ser Gly Lys Gln Glu Ile Thr Leu Pro Pro Ser Arg Lys Ser Glu Leu 
        595                 600                 605             


Val Val Glu Val Lys Ser Asp Lys Leu Pro Glu Glu Met Gly Leu Leu 
    610                 615                 620                 


Gln Gly Ser Ser Gly Asp Lys Arg Ala Pro Gly Asp Gln Gly Glu Lys 
625                 630                 635                 640 


Tyr Ile Asp Leu Arg His 
                645     


<210>  253
<211>  178
<212>  PRT
<213>  Homo sapiens

<400>  253

Met Ser Arg Leu Ser Arg Ser Leu Leu Trp Ala Ala Thr Cys Leu Gly 
1               5                   10                  15      


Val Leu Cys Val Leu Ser Ala Asp Lys Asn Thr Thr Gln His Pro Asn 
            20                  25                  30          


Val Thr Thr Leu Ala Pro Ile Ser Asn Val Thr Ser Ala Pro Val Thr 
        35                  40                  45              


Ser Leu Pro Leu Val Thr Thr Pro Ala Pro Glu Thr Cys Glu Gly Arg 
    50                  55                  60                  


Asn Ser Cys Val Ser Cys Phe Asn Val Ser Val Val Asn Thr Thr Cys 
65                  70                  75                  80  


Phe Trp Ile Glu Cys Lys Asp Glu Ser Tyr Cys Ser His Asn Ser Thr 
                85                  90                  95      


Val Ser Asp Cys Gln Val Gly Asn Thr Thr Asp Phe Cys Ser Val Ser 
            100                 105                 110         


Thr Ala Thr Pro Val Pro Thr Ala Asn Ser Thr Gly Thr Thr Asn Asn 
        115                 120                 125             


Thr Val Thr Pro Thr Ser Gln Pro Val Arg Lys Ser Thr Phe Asp Ala 
    130                 135                 140                 


Ala Ser Phe Ile Gly Gly Ile Val Leu Val Leu Gly Val Gln Ala Val 
145                 150                 155                 160 


Ile Phe Phe Leu Tyr Lys Phe Cys Lys Ser Lys Glu Arg Asn Tyr His 
                165                 170                 175     


Thr Leu 
        


<210>  254
<211>  583
<212>  PRT
<213>  Homo sapiens

<400>  254

Met Glu Ser Lys Gly Ala Ser Ser Cys Arg Leu Leu Phe Cys Leu Leu 
1               5                   10                  15      


Ile Ser Ala Thr Val Phe Arg Pro Gly Leu Gly Trp Tyr Thr Val Asn 
            20                  25                  30          


Ser Ala Tyr Gly Asp Thr Ile Ile Ile Pro Cys Arg Leu Asp Val Pro 
        35                  40                  45              


Gln Asn Leu Met Phe Gly Lys Trp Lys Tyr Glu Lys Pro Asp Gly Ser 
    50                  55                  60                  


Pro Val Phe Ile Ala Phe Arg Ser Ser Thr Lys Lys Ser Val Gln Tyr 
65                  70                  75                  80  


Asp Asp Val Pro Glu Tyr Lys Asp Arg Leu Asn Leu Ser Glu Asn Tyr 
                85                  90                  95      


Thr Leu Ser Ile Ser Asn Ala Arg Ile Ser Asp Glu Lys Arg Phe Val 
            100                 105                 110         


Cys Met Leu Val Thr Glu Asp Asn Val Phe Glu Ala Pro Thr Ile Val 
        115                 120                 125             


Lys Val Phe Lys Gln Pro Ser Lys Pro Glu Ile Val Ser Lys Ala Leu 
    130                 135                 140                 


Phe Leu Glu Thr Glu Gln Leu Lys Lys Leu Gly Asp Cys Ile Ser Glu 
145                 150                 155                 160 


Asp Ser Tyr Pro Asp Gly Asn Ile Thr Trp Tyr Arg Asn Gly Lys Val 
                165                 170                 175     


Leu His Pro Leu Glu Gly Ala Val Val Ile Ile Phe Lys Lys Glu Met 
            180                 185                 190         


Asp Pro Val Thr Gln Leu Tyr Thr Met Thr Ser Thr Leu Glu Tyr Lys 
        195                 200                 205             


Thr Thr Lys Ala Asp Ile Gln Met Pro Phe Thr Cys Ser Val Thr Tyr 
    210                 215                 220                 


Tyr Gly Pro Ser Gly Gln Lys Thr Ile His Ser Glu Gln Ala Val Phe 
225                 230                 235                 240 


Asp Ile Tyr Tyr Pro Thr Glu Gln Val Thr Ile Gln Val Leu Pro Pro 
                245                 250                 255     


Lys Asn Ala Ile Lys Glu Gly Asp Asn Ile Thr Leu Lys Cys Leu Gly 
            260                 265                 270         


Asn Gly Asn Pro Pro Pro Glu Glu Phe Leu Phe Tyr Leu Pro Gly Gln 
        275                 280                 285             


Pro Glu Gly Ile Arg Ser Ser Asn Thr Tyr Thr Leu Thr Asp Val Arg 
    290                 295                 300                 


Arg Asn Ala Thr Gly Asp Tyr Lys Cys Ser Leu Ile Asp Lys Lys Ser 
305                 310                 315                 320 


Met Ile Ala Ser Thr Ala Ile Thr Val His Tyr Leu Asp Leu Ser Leu 
                325                 330                 335     


Asn Pro Ser Gly Glu Val Thr Arg Gln Ile Gly Asp Ala Leu Pro Val 
            340                 345                 350         


Ser Cys Thr Ile Ser Ala Ser Arg Asn Ala Thr Val Val Trp Met Lys 
        355                 360                 365             


Asp Asn Ile Arg Leu Arg Ser Ser Pro Ser Phe Ser Ser Leu His Tyr 
    370                 375                 380                 


Gln Asp Ala Gly Asn Tyr Val Cys Glu Thr Ala Leu Gln Glu Val Glu 
385                 390                 395                 400 


Gly Leu Lys Lys Arg Glu Ser Leu Thr Leu Ile Val Glu Gly Lys Pro 
                405                 410                 415     


Gln Ile Lys Met Thr Lys Lys Thr Asp Pro Ser Gly Leu Ser Lys Thr 
            420                 425                 430         


Ile Ile Cys His Val Glu Gly Phe Pro Lys Pro Ala Ile Gln Trp Thr 
        435                 440                 445             


Ile Thr Gly Ser Gly Ser Val Ile Asn Gln Thr Glu Glu Ser Pro Tyr 
    450                 455                 460                 


Ile Asn Gly Arg Tyr Tyr Ser Lys Ile Ile Ile Ser Pro Glu Glu Asn 
465                 470                 475                 480 


Val Thr Leu Thr Cys Thr Ala Glu Asn Gln Leu Glu Arg Thr Val Asn 
                485                 490                 495     


Ser Leu Asn Val Ser Ala Ile Ser Ile Pro Glu His Asp Glu Ala Asp 
            500                 505                 510         


Glu Ile Ser Asp Glu Asn Arg Glu Lys Val Asn Asp Gln Ala Lys Leu 
        515                 520                 525             


Ile Val Gly Ile Val Val Gly Leu Leu Leu Ala Ala Leu Val Ala Gly 
    530                 535                 540                 


Val Val Tyr Trp Leu Tyr Met Lys Lys Ser Lys Thr Ala Ser Lys His 
545                 550                 555                 560 


Val Asn Lys Asp Leu Gly Asn Met Glu Glu Asn Lys Lys Leu Glu Glu 
                565                 570                 575     


Asn Asn His Lys Thr Glu Ala 
            580             


<210>  255
<211>  317
<212>  PRT
<213>  Homo sapiens

<400>  255

Met Lys Thr Ala Leu Ile Leu Leu Ser Ile Leu Gly Met Ala Cys Ala 
1               5                   10                  15      


Phe Ser Met Lys Asn Leu His Arg Arg Val Lys Ile Glu Asp Ser Glu 
            20                  25                  30          


Glu Asn Gly Val Phe Lys Tyr Arg Pro Arg Tyr Tyr Leu Tyr Lys His 
        35                  40                  45              


Ala Tyr Phe Tyr Pro His Leu Lys Arg Phe Pro Val Gln Gly Ser Ser 
    50                  55                  60                  


Asp Ser Ser Glu Glu Asn Gly Asp Asp Ser Ser Glu Glu Glu Glu Glu 
65                  70                  75                  80  


Glu Glu Glu Thr Ser Asn Glu Gly Glu Asn Asn Glu Glu Ser Asn Glu 
                85                  90                  95      


Asp Glu Asp Ser Glu Ala Glu Asn Thr Thr Leu Ser Ala Thr Thr Leu 
            100                 105                 110         


Gly Tyr Gly Glu Asp Ala Thr Pro Gly Thr Gly Tyr Thr Gly Leu Ala 
        115                 120                 125             


Ala Ile Gln Leu Pro Lys Lys Ala Gly Asp Ile Thr Asn Lys Ala Thr 
    130                 135                 140                 


Lys Glu Lys Glu Ser Asp Glu Glu Glu Glu Glu Glu Glu Glu Gly Asn 
145                 150                 155                 160 


Glu Asn Glu Glu Ser Glu Ala Glu Val Asp Glu Asn Glu Gln Gly Ile 
                165                 170                 175     


Asn Gly Thr Ser Thr Asn Ser Thr Glu Ala Glu Asn Gly Asn Gly Ser 
            180                 185                 190         


Ser Gly Gly Asp Asn Gly Glu Glu Gly Glu Glu Glu Ser Val Thr Gly 
        195                 200                 205             


Ala Asn Ala Glu Asp Thr Thr Glu Thr Gly Arg Gln Gly Lys Gly Thr 
    210                 215                 220                 


Ser Lys Thr Thr Thr Ser Pro Asn Gly Gly Phe Glu Pro Thr Thr Pro 
225                 230                 235                 240 


Pro Gln Val Tyr Arg Thr Thr Ser Pro Pro Phe Gly Lys Thr Thr Thr 
                245                 250                 255     


Val Glu Tyr Glu Gly Glu Tyr Glu Tyr Thr Gly Ala Asn Glu Tyr Asp 
            260                 265                 270         


Asn Gly Tyr Glu Ile Tyr Glu Ser Glu Asn Gly Glu Pro Arg Gly Asp 
        275                 280                 285             


Asn Tyr Arg Ala Tyr Glu Asp Glu Tyr Ser Tyr Phe Lys Gly Gln Gly 
    290                 295                 300                 


Tyr Asp Gly Tyr Asp Gly Gln Asn Tyr Tyr His His Gln 
305                 310                 315         


<210>  256
<211>  532
<212>  PRT
<213>  Homo sapiens

<400>  256

Met Ala Pro Ser Ser Pro Arg Pro Ala Leu Pro Ala Leu Leu Val Leu 
1               5                   10                  15      


Leu Gly Ala Leu Phe Pro Gly Pro Gly Asn Ala Gln Thr Ser Val Ser 
            20                  25                  30          


Pro Ser Lys Val Ile Leu Pro Arg Gly Gly Ser Val Leu Val Thr Cys 
        35                  40                  45              


Ser Thr Ser Cys Asp Gln Pro Lys Leu Leu Gly Ile Glu Thr Pro Leu 
    50                  55                  60                  


Pro Lys Lys Glu Leu Leu Leu Pro Gly Asn Asn Arg Lys Val Tyr Glu 
65                  70                  75                  80  


Leu Ser Asn Val Gln Glu Asp Ser Gln Pro Met Cys Tyr Ser Asn Cys 
                85                  90                  95      


Pro Asp Gly Gln Ser Thr Ala Lys Thr Phe Leu Thr Val Tyr Trp Thr 
            100                 105                 110         


Pro Glu Arg Val Glu Leu Ala Pro Leu Pro Ser Trp Gln Pro Val Gly 
        115                 120                 125             


Lys Asn Leu Thr Leu Arg Cys Gln Val Glu Gly Gly Ala Pro Arg Ala 
    130                 135                 140                 


Asn Leu Thr Val Val Leu Leu Arg Gly Glu Lys Glu Leu Lys Arg Glu 
145                 150                 155                 160 


Pro Ala Val Gly Glu Pro Ala Glu Val Thr Thr Thr Val Leu Val Arg 
                165                 170                 175     


Arg Asp His His Gly Ala Asn Phe Ser Cys Arg Thr Glu Leu Asp Leu 
            180                 185                 190         


Arg Pro Gln Gly Leu Glu Leu Phe Glu Asn Thr Ser Ala Pro Tyr Gln 
        195                 200                 205             


Leu Gln Thr Phe Val Leu Pro Ala Thr Pro Pro Gln Leu Val Ser Pro 
    210                 215                 220                 


Arg Val Leu Glu Val Asp Thr Gln Gly Thr Val Val Cys Ser Leu Asp 
225                 230                 235                 240 


Gly Leu Phe Pro Val Ser Glu Ala Gln Val His Leu Ala Leu Gly Asp 
                245                 250                 255     


Gln Arg Leu Asn Pro Thr Val Thr Tyr Gly Asn Asp Ser Phe Ser Ala 
            260                 265                 270         


Lys Ala Ser Val Ser Val Thr Ala Glu Asp Glu Gly Thr Gln Arg Leu 
        275                 280                 285             


Thr Cys Ala Val Ile Leu Gly Asn Gln Ser Gln Glu Thr Leu Gln Thr 
    290                 295                 300                 


Val Thr Ile Tyr Ser Phe Pro Ala Pro Asn Val Ile Leu Thr Lys Pro 
305                 310                 315                 320 


Glu Val Ser Glu Gly Thr Glu Val Thr Val Lys Cys Glu Ala His Pro 
                325                 330                 335     


Arg Ala Lys Val Thr Leu Asn Gly Val Pro Ala Gln Pro Leu Gly Pro 
            340                 345                 350         


Arg Ala Gln Leu Leu Leu Lys Ala Thr Pro Glu Asp Asn Gly Arg Ser 
        355                 360                 365             


Phe Ser Cys Ser Ala Thr Leu Glu Val Ala Gly Gln Leu Ile His Lys 
    370                 375                 380                 


Asn Gln Thr Arg Glu Leu Arg Val Leu Tyr Gly Pro Arg Leu Asp Glu 
385                 390                 395                 400 


Arg Asp Cys Pro Gly Asn Trp Thr Trp Pro Glu Asn Ser Gln Gln Thr 
                405                 410                 415     


Pro Met Cys Gln Ala Trp Gly Asn Pro Leu Pro Glu Leu Lys Cys Leu 
            420                 425                 430         


Lys Asp Gly Thr Phe Pro Leu Pro Ile Gly Glu Ser Val Thr Val Thr 
        435                 440                 445             


Arg Asp Leu Glu Gly Thr Tyr Leu Cys Arg Ala Arg Ser Thr Gln Gly 
    450                 455                 460                 


Glu Val Thr Arg Lys Val Thr Val Asn Val Leu Ser Pro Arg Tyr Glu 
465                 470                 475                 480 


Ile Val Ile Ile Thr Val Val Ala Ala Ala Val Ile Met Gly Thr Ala 
                485                 490                 495     


Gly Leu Ser Thr Tyr Leu Tyr Asn Arg Gln Arg Lys Ile Lys Lys Tyr 
            500                 505                 510         


Arg Leu Gln Gln Ala Gln Lys Gly Thr Pro Met Lys Pro Asn Thr Gln 
        515                 520                 525             


Ala Thr Pro Pro 
    530         


<210>  257
<211>  137
<212>  PRT
<213>  Homo sapiens

<400>  257

Met Tyr Gly Lys Ile Ile Phe Val Leu Leu Leu Ser Glu Ile Val Ser 
1               5                   10                  15      


Ile Ser Ala Leu Ser Thr Thr Glu Val Ala Met His Thr Ser Thr Ser 
            20                  25                  30          


Ser Ser Val Thr Lys Ser Tyr Ile Ser Ser Gln Thr Asn Asp Thr His 
        35                  40                  45              


Lys Arg Asp Thr Tyr Ala Ala Thr Pro Arg Ala His Glu Val Ser Glu 
    50                  55                  60                  


Ile Ser Val Arg Thr Val Tyr Pro Pro Glu Glu Glu Thr Glu Ile Thr 
65                  70                  75                  80  


Leu Ile Ile Phe Gly Val Met Ala Gly Val Ile Gly Thr Ile Leu Leu 
                85                  90                  95      


Ile Ser Tyr Gly Ile Arg Arg Leu Ile Lys Lys Ser Pro Ser Asp Val 
            100                 105                 110         


Lys Pro Leu Pro Ser Pro Asp Thr Asp Val Pro Leu Ser Ser Val Glu 
        115                 120                 125             


Ile Glu Asn Pro Glu Thr Ser Asp Gln 
    130                 135         


<210>  258
<211>  883
<212>  PRT
<213>  Homo sapiens

<400>  258

Met Gln Lys Ile Met His Ile Ser Val Leu Leu Ser Pro Val Leu Trp 
1               5                   10                  15      


Gly Leu Ile Phe Gly Val Ser Ser Asn Ser Ile Gln Ile Gly Gly Leu 
            20                  25                  30          


Phe Pro Arg Gly Ala Asp Gln Glu Tyr Ser Ala Phe Arg Val Gly Met 
        35                  40                  45              


Val Gln Phe Ser Thr Ser Glu Phe Arg Leu Thr Pro His Ile Asp Asn 
    50                  55                  60                  


Leu Glu Val Ala Asn Ser Phe Ala Val Thr Asn Ala Phe Cys Ser Gln 
65                  70                  75                  80  


Phe Ser Arg Gly Val Tyr Ala Ile Phe Gly Phe Tyr Asp Lys Lys Ser 
                85                  90                  95      


Val Asn Thr Ile Thr Ser Phe Cys Gly Thr Leu His Val Ser Phe Ile 
            100                 105                 110         


Thr Pro Ser Phe Pro Thr Asp Gly Thr His Pro Phe Val Ile Gln Met 
        115                 120                 125             


Arg Pro Asp Leu Lys Gly Ala Leu Leu Ser Leu Ile Glu Tyr Tyr Gln 
    130                 135                 140                 


Trp Asp Lys Phe Ala Tyr Leu Tyr Asp Ser Asp Arg Gly Leu Ser Thr 
145                 150                 155                 160 


Leu Gln Ala Val Leu Asp Ser Ala Ala Glu Lys Lys Trp Gln Val Thr 
                165                 170                 175     


Ala Ile Asn Val Gly Asn Ile Asn Asn Asp Lys Lys Asp Glu Met Tyr 
            180                 185                 190         


Arg Ser Leu Phe Gln Asp Leu Glu Leu Lys Lys Glu Arg Arg Val Ile 
        195                 200                 205             


Leu Asp Cys Glu Arg Asp Lys Val Asn Asp Ile Val Asp Gln Val Ile 
    210                 215                 220                 


Thr Ile Gly Lys His Val Lys Gly Tyr His Tyr Ile Ile Ala Asn Leu 
225                 230                 235                 240 


Gly Phe Thr Asp Gly Asp Leu Leu Lys Ile Gln Phe Gly Gly Ala Asn 
                245                 250                 255     


Val Ser Gly Phe Gln Ile Val Asp Tyr Asp Asp Ser Leu Val Ser Lys 
            260                 265                 270         


Phe Ile Glu Arg Trp Ser Thr Leu Glu Glu Lys Glu Tyr Pro Gly Ala 
        275                 280                 285             


His Thr Thr Thr Ile Lys Tyr Thr Ser Ala Leu Thr Tyr Asp Ala Val 
    290                 295                 300                 


Gln Val Met Thr Glu Ala Phe Arg Asn Leu Arg Lys Gln Arg Ile Glu 
305                 310                 315                 320 


Ile Ser Arg Arg Gly Asn Ala Gly Asp Cys Leu Ala Asn Pro Ala Val 
                325                 330                 335     


Pro Trp Gly Gln Gly Val Glu Ile Glu Arg Ala Leu Lys Gln Val Gln 
            340                 345                 350         


Val Glu Gly Leu Ser Gly Asn Ile Lys Phe Asp Gln Asn Gly Lys Arg 
        355                 360                 365             


Ile Asn Tyr Thr Ile Asn Ile Met Glu Leu Lys Thr Asn Gly Pro Arg 
    370                 375                 380                 


Lys Ile Gly Tyr Trp Ser Glu Val Asp Lys Met Val Val Thr Leu Thr 
385                 390                 395                 400 


Glu Leu Pro Ser Gly Asn Asp Thr Ser Gly Leu Glu Asn Lys Thr Val 
                405                 410                 415     


Val Val Thr Thr Ile Leu Glu Ser Pro Tyr Val Met Met Lys Lys Asn 
            420                 425                 430         


His Glu Met Leu Glu Gly Asn Glu Arg Tyr Glu Gly Tyr Cys Val Asp 
        435                 440                 445             


Leu Ala Ala Glu Ile Ala Lys His Cys Gly Phe Lys Tyr Lys Leu Thr 
    450                 455                 460                 


Ile Val Gly Asp Gly Lys Tyr Gly Ala Arg Asp Ala Asp Thr Lys Ile 
465                 470                 475                 480 


Trp Asn Gly Met Val Gly Glu Leu Val Tyr Gly Lys Ala Asp Ile Ala 
                485                 490                 495     


Ile Ala Pro Leu Thr Ile Thr Leu Val Arg Glu Glu Val Ile Asp Phe 
            500                 505                 510         


Ser Lys Pro Phe Met Ser Leu Gly Ile Ser Ile Met Ile Lys Lys Pro 
        515                 520                 525             


Gln Lys Ser Lys Pro Gly Val Phe Ser Phe Leu Asp Pro Leu Ala Tyr 
    530                 535                 540                 


Glu Ile Trp Met Cys Ile Val Phe Ala Tyr Ile Gly Val Ser Val Val 
545                 550                 555                 560 


Leu Phe Leu Val Ser Arg Phe Ser Pro Tyr Glu Trp His Thr Glu Glu 
                565                 570                 575     


Phe Glu Asp Gly Arg Glu Thr Gln Ser Ser Glu Ser Thr Asn Glu Phe 
            580                 585                 590         


Gly Ile Phe Asn Ser Leu Trp Phe Ser Leu Gly Ala Phe Met Gln Gln 
        595                 600                 605             


Gly Cys Asp Ile Ser Pro Arg Ser Leu Ser Gly Arg Ile Val Gly Gly 
    610                 615                 620                 


Val Trp Trp Phe Phe Thr Leu Ile Ile Ile Ser Ser Tyr Thr Ala Asn 
625                 630                 635                 640 


Leu Ala Ala Phe Leu Thr Val Glu Arg Met Val Ser Pro Ile Glu Ser 
                645                 650                 655     


Ala Glu Asp Leu Ser Lys Gln Thr Glu Ile Ala Tyr Gly Thr Leu Asp 
            660                 665                 670         


Ser Gly Ser Thr Lys Glu Phe Phe Arg Arg Ser Lys Ile Ala Val Phe 
        675                 680                 685             


Asp Lys Met Trp Thr Tyr Met Arg Ser Ala Glu Pro Ser Val Phe Val 
    690                 695                 700                 


Arg Thr Thr Ala Glu Gly Val Ala Arg Val Arg Lys Ser Lys Gly Lys 
705                 710                 715                 720 


Tyr Ala Tyr Leu Leu Glu Ser Thr Met Asn Glu Tyr Ile Glu Gln Arg 
                725                 730                 735     


Lys Pro Cys Asp Thr Met Lys Val Gly Gly Asn Leu Asp Ser Lys Gly 
            740                 745                 750         


Tyr Gly Ile Ala Thr Pro Lys Gly Ser Ser Leu Arg Thr Pro Val Asn 
        755                 760                 765             


Leu Ala Val Leu Lys Leu Ser Glu Gln Gly Val Leu Asp Lys Leu Lys 
    770                 775                 780                 


Asn Lys Trp Trp Tyr Asp Lys Gly Glu Cys Gly Ala Lys Asp Ser Gly 
785                 790                 795                 800 


Ser Lys Glu Lys Thr Ser Ala Leu Ser Leu Ser Asn Val Ala Gly Val 
                805                 810                 815     


Phe Tyr Ile Leu Val Gly Gly Leu Gly Leu Ala Met Leu Val Ala Leu 
            820                 825                 830         


Ile Glu Phe Cys Tyr Lys Ser Arg Ala Glu Ala Lys Arg Met Lys Val 
        835                 840                 845             


Ala Lys Asn Ala Gln Asn Ile Asn Pro Ser Ser Ser Gln Asn Ser Gln 
    850                 855                 860                 


Asn Phe Ala Thr Tyr Lys Glu Gly Tyr Asn Val Tyr Gly Ile Glu Ser 
865                 870                 875                 880 


Val Lys Ile 
            


<210>  259
<211>  894
<212>  PRT
<213>  Homo sapiens

<400>  259

Met Ala Arg Gln Lys Lys Met Gly Gln Ser Val Leu Arg Ala Val Phe 
1               5                   10                  15      


Phe Leu Val Leu Gly Leu Leu Gly His Ser His Gly Gly Phe Pro Asn 
            20                  25                  30          


Thr Ile Ser Ile Gly Gly Leu Phe Met Arg Asn Thr Val Gln Glu His 
        35                  40                  45              


Ser Ala Phe Arg Phe Ala Val Gln Leu Tyr Asn Thr Asn Gln Asn Thr 
    50                  55                  60                  


Thr Glu Lys Pro Phe His Leu Asn Tyr His Val Asp His Leu Asp Ser 
65                  70                  75                  80  


Ser Asn Ser Phe Ser Val Thr Asn Ala Phe Cys Ser Gln Phe Ser Arg 
                85                  90                  95      


Gly Val Tyr Ala Ile Phe Gly Phe Tyr Asp Gln Met Ser Met Asn Thr 
            100                 105                 110         


Leu Thr Ser Phe Cys Gly Ala Leu His Thr Ser Phe Val Thr Pro Ser 
        115                 120                 125             


Phe Pro Thr Asp Ala Asp Val Gln Phe Val Ile Gln Met Arg Pro Ala 
    130                 135                 140                 


Leu Lys Gly Ala Ile Leu Ser Leu Leu Gly His Tyr Lys Trp Glu Lys 
145                 150                 155                 160 


Phe Val Tyr Leu Tyr Asp Thr Glu Arg Gly Phe Ser Ile Leu Gln Ala 
                165                 170                 175     


Ile Met Glu Ala Ala Val Gln Asn Asn Trp Gln Val Thr Ala Arg Ser 
            180                 185                 190         


Val Gly Asn Ile Lys Asp Val Gln Glu Phe Arg Arg Ile Ile Glu Glu 
        195                 200                 205             


Met Asp Arg Arg Gln Glu Lys Arg Tyr Leu Ile Asp Cys Glu Val Glu 
    210                 215                 220                 


Arg Ile Asn Thr Ile Leu Glu Gln Val Val Ile Leu Gly Lys His Ser 
225                 230                 235                 240 


Arg Gly Tyr His Tyr Met Leu Ala Asn Leu Gly Phe Thr Asp Ile Leu 
                245                 250                 255     


Leu Glu Arg Val Met His Gly Gly Ala Asn Ile Thr Gly Phe Gln Ile 
            260                 265                 270         


Val Asn Asn Glu Asn Pro Met Val Gln Gln Phe Ile Gln Arg Trp Val 
        275                 280                 285             


Arg Leu Asp Glu Arg Glu Phe Pro Glu Ala Lys Asn Ala Pro Leu Lys 
    290                 295                 300                 


Tyr Thr Ser Ala Leu Thr His Asp Ala Ile Leu Val Ile Ala Glu Ala 
305                 310                 315                 320 


Phe Arg Tyr Leu Arg Arg Gln Arg Val Asp Val Ser Arg Arg Gly Ser 
                325                 330                 335     


Ala Gly Asp Cys Leu Ala Asn Pro Ala Val Pro Trp Ser Gln Gly Ile 
            340                 345                 350         


Asp Ile Glu Arg Ala Leu Lys Met Val Gln Val Gln Gly Met Thr Gly 
        355                 360                 365             


Asn Ile Gln Phe Asp Thr Tyr Gly Arg Arg Thr Asn Tyr Thr Ile Asp 
    370                 375                 380                 


Val Tyr Glu Met Lys Val Ser Gly Ser Arg Lys Ala Gly Tyr Trp Asn 
385                 390                 395                 400 


Glu Tyr Glu Arg Phe Val Pro Phe Ser Asp Gln Gln Ile Ser Asn Asp 
                405                 410                 415     


Ser Ala Ser Ser Glu Asn Arg Thr Ile Val Val Thr Thr Ile Leu Glu 
            420                 425                 430         


Ser Pro Tyr Val Met Tyr Lys Lys Asn His Glu Gln Leu Glu Gly Asn 
        435                 440                 445             


Glu Arg Tyr Glu Gly Tyr Cys Val Asp Leu Ala Tyr Glu Ile Ala Lys 
    450                 455                 460                 


His Val Arg Ile Lys Tyr Lys Leu Ser Ile Val Gly Asp Gly Lys Tyr 
465                 470                 475                 480 


Gly Ala Arg Asp Pro Glu Thr Lys Ile Trp Asn Gly Met Val Gly Glu 
                485                 490                 495     


Leu Val Tyr Gly Arg Ala Asp Ile Ala Val Ala Pro Leu Thr Ile Thr 
            500                 505                 510         


Leu Val Arg Glu Glu Val Ile Asp Phe Ser Lys Pro Phe Met Ser Leu 
        515                 520                 525             


Gly Ile Ser Ile Met Ile Lys Lys Pro Gln Lys Ser Lys Pro Gly Val 
    530                 535                 540                 


Phe Ser Phe Leu Asp Pro Leu Ala Tyr Glu Ile Trp Met Cys Ile Val 
545                 550                 555                 560 


Phe Ala Tyr Ile Gly Val Ser Val Val Leu Phe Leu Val Ser Arg Phe 
                565                 570                 575     


Ser Pro Tyr Glu Trp His Leu Glu Asp Asn Asn Glu Glu Pro Arg Asp 
            580                 585                 590         


Pro Gln Ser Pro Pro Asp Pro Pro Asn Glu Phe Gly Ile Phe Asn Ser 
        595                 600                 605             


Leu Trp Phe Ser Leu Gly Ala Phe Met Gln Gln Gly Cys Asp Ile Ser 
    610                 615                 620                 


Pro Arg Ser Leu Ser Gly Arg Ile Val Gly Gly Val Trp Trp Phe Phe 
625                 630                 635                 640 


Thr Leu Ile Ile Ile Ser Ser Tyr Thr Ala Asn Leu Ala Ala Phe Leu 
                645                 650                 655     


Thr Val Glu Arg Met Val Ser Pro Ile Glu Ser Ala Glu Asp Leu Ala 
            660                 665                 670         


Lys Gln Thr Glu Ile Ala Tyr Gly Thr Leu Asp Ser Gly Ser Thr Lys 
        675                 680                 685             


Glu Phe Phe Arg Arg Ser Lys Ile Ala Val Tyr Glu Lys Met Trp Ser 
    690                 695                 700                 


Tyr Met Lys Ser Ala Glu Pro Ser Val Phe Thr Lys Thr Thr Ala Asp 
705                 710                 715                 720 


Gly Val Ala Arg Val Arg Lys Ser Lys Gly Lys Phe Ala Phe Leu Leu 
                725                 730                 735     


Glu Ser Thr Met Asn Glu Tyr Ile Glu Gln Arg Lys Pro Cys Asp Thr 
            740                 745                 750         


Met Lys Val Gly Gly Asn Leu Asp Ser Lys Gly Tyr Gly Val Ala Thr 
        755                 760                 765             


Pro Lys Gly Ser Ala Leu Gly Asn Ala Val Asn Leu Ala Val Leu Lys 
    770                 775                 780                 


Leu Asn Glu Gln Gly Leu Leu Asp Lys Leu Lys Asn Lys Trp Trp Tyr 
785                 790                 795                 800 


Asp Lys Gly Glu Cys Gly Ser Gly Gly Gly Asp Ser Lys Asp Lys Thr 
                805                 810                 815     


Ser Ala Leu Ser Leu Ser Asn Val Ala Gly Val Phe Tyr Ile Leu Val 
            820                 825                 830         


Gly Gly Leu Gly Leu Ala Met Met Val Ala Leu Ile Glu Phe Cys Tyr 
        835                 840                 845             


Lys Ser Arg Ala Glu Ser Lys Arg Met Lys Leu Thr Lys Asn Thr Gln 
    850                 855                 860                 


Asn Phe Lys Pro Ala Pro Ala Thr Asn Thr Gln Asn Tyr Ala Thr Tyr 
865                 870                 875                 880 


Arg Glu Gly Tyr Asn Val Tyr Gly Thr Glu Ser Val Lys Ile 
                885                 890                 


<210>  260
<211>  261
<212>  PRT
<213>  Homo sapiens

<400>  260

Met Gly His Glu Gln Asn Gln Gly Ala Ala Leu Leu Gln Met Leu Pro 
1               5                   10                  15      


Leu Leu Trp Leu Leu Pro His Ser Trp Ala Val Pro Glu Ala Pro Thr 
            20                  25                  30          


Pro Met Trp Pro Asp Asp Leu Gln Asn His Thr Phe Leu His Thr Val 
        35                  40                  45              


Tyr Cys Gln Asp Gly Ser Pro Ser Val Gly Leu Ser Glu Ala Tyr Asp 
    50                  55                  60                  


Glu Asp Gln Leu Phe Phe Phe Asp Phe Ser Gln Asn Thr Arg Val Pro 
65                  70                  75                  80  


Arg Leu Pro Glu Phe Ala Asp Trp Ala Gln Glu Gln Gly Asp Ala Pro 
                85                  90                  95      


Ala Ile Leu Phe Asp Lys Glu Phe Cys Glu Trp Met Ile Gln Gln Ile 
            100                 105                 110         


Gly Pro Lys Leu Asp Gly Lys Ile Pro Val Ser Arg Gly Phe Pro Ile 
        115                 120                 125             


Ala Glu Val Phe Thr Leu Lys Pro Leu Glu Phe Gly Lys Pro Asn Thr 
    130                 135                 140                 


Leu Val Cys Phe Val Ser Asn Leu Phe Pro Pro Met Leu Thr Val Asn 
145                 150                 155                 160 


Trp Gln His His Ser Val Pro Val Glu Gly Phe Gly Pro Thr Phe Val 
                165                 170                 175     


Ser Ala Val Asp Gly Leu Ser Phe Gln Ala Phe Ser Tyr Leu Asn Phe 
            180                 185                 190         


Thr Pro Glu Pro Ser Asp Ile Phe Ser Cys Ile Val Thr His Glu Ile 
        195                 200                 205             


Asp Arg Tyr Thr Ala Ile Ala Tyr Trp Val Pro Arg Asn Ala Leu Pro 
    210                 215                 220                 


Ser Asp Leu Leu Glu Asn Val Leu Cys Gly Val Ala Phe Gly Leu Gly 
225                 230                 235                 240 


Val Leu Gly Ile Ile Val Gly Ile Val Leu Ile Ile Tyr Phe Arg Lys 
                245                 250                 255     


Pro Cys Ser Gly Asp 
            260     


<210>  261
<211>  428
<212>  PRT
<213>  Homo sapiens

<400>  261

Met Gly Asn Cys His Thr Val Gly Pro Asn Glu Ala Leu Val Val Ser 
1               5                   10                  15      


Gly Gly Cys Cys Gly Ser Asp Tyr Lys Gln Tyr Val Phe Gly Gly Trp 
            20                  25                  30          


Ala Trp Ala Trp Trp Cys Ile Ser Asp Thr Gln Arg Ile Ser Leu Glu 
        35                  40                  45              


Ile Met Thr Leu Gln Pro Arg Cys Glu Asp Val Glu Thr Ala Glu Gly 
    50                  55                  60                  


Val Ala Leu Thr Val Thr Gly Val Ala Gln Val Lys Ile Met Thr Glu 
65                  70                  75                  80  


Lys Glu Leu Leu Ala Val Ala Cys Glu Gln Phe Leu Gly Lys Asn Val 
                85                  90                  95      


Gln Asp Ile Lys Asn Val Val Leu Gln Thr Leu Glu Gly His Leu Arg 
            100                 105                 110         


Ser Ile Leu Gly Thr Leu Thr Val Glu Gln Ile Tyr Gln Asp Arg Asp 
        115                 120                 125             


Gln Phe Ala Lys Leu Val Arg Glu Val Ala Ala Pro Asp Val Gly Arg 
    130                 135                 140                 


Met Gly Ile Glu Ile Leu Ser Phe Thr Ile Lys Asp Val Tyr Asp Lys 
145                 150                 155                 160 


Val Asp Tyr Leu Ser Ser Leu Gly Lys Thr Gln Thr Ala Val Val Gln 
                165                 170                 175     


Arg Asp Ala Asp Ile Gly Val Ala Glu Ala Glu Arg Asp Ala Gly Ile 
            180                 185                 190         


Arg Glu Ala Glu Cys Lys Lys Glu Met Leu Asp Val Lys Phe Met Ala 
        195                 200                 205             


Asp Thr Lys Ile Ala Asp Ser Lys Arg Ala Phe Glu Leu Gln Lys Ser 
    210                 215                 220                 


Ala Phe Ser Glu Glu Val Asn Ile Lys Thr Ala Glu Ala Gln Leu Ala 
225                 230                 235                 240 


Tyr Glu Leu Gln Gly Ala Arg Glu Gln Gln Lys Ile Arg Gln Glu Glu 
                245                 250                 255     


Ile Glu Ile Glu Val Val Gln Arg Lys Lys Gln Ile Ala Val Glu Ala 
            260                 265                 270         


Gln Glu Ile Leu Arg Thr Asp Lys Glu Leu Ile Ala Thr Val Arg Arg 
        275                 280                 285             


Pro Ala Glu Ala Glu Ala His Arg Ile Gln Gln Ile Ala Glu Gly Glu 
    290                 295                 300                 


Lys Val Lys Gln Val Leu Leu Ala Gln Ala Glu Ala Glu Lys Ile Arg 
305                 310                 315                 320 


Lys Ile Gly Glu Ala Glu Ala Ala Val Ile Glu Ala Met Gly Lys Ala 
                325                 330                 335     


Glu Ala Glu Arg Met Lys Leu Lys Ala Glu Ala Tyr Gln Lys Tyr Gly 
            340                 345                 350         


Asp Ala Ala Lys Met Ala Leu Val Leu Glu Ala Leu Pro Gln Ile Ala 
        355                 360                 365             


Ala Lys Ile Ala Ala Pro Leu Thr Lys Val Asp Glu Ile Val Val Leu 
    370                 375                 380                 


Ser Gly Asp Asn Ser Lys Val Thr Ser Glu Val Asn Arg Leu Leu Ala 
385                 390                 395                 400 


Glu Leu Pro Ala Ser Val His Ala Leu Thr Gly Val Asp Leu Ser Lys 
                405                 410                 415     


Ile Pro Leu Ile Lys Lys Ala Thr Gly Val Gln Val 
            420                 425             


<210>  262
<211>  865
<212>  PRT
<213>  Homo sapiens

<400>  262

Met Ala Leu Val Leu Gly Ser Leu Leu Leu Leu Gly Leu Cys Gly Asn 
1               5                   10                  15      


Ser Phe Ser Gly Gly Gln Pro Ser Ser Thr Asp Ala Pro Lys Ala Trp 
            20                  25                  30          


Asn Tyr Glu Leu Pro Ala Thr Asn Tyr Glu Thr Gln Asp Ser His Lys 
        35                  40                  45              


Ala Gly Pro Ile Gly Ile Leu Phe Glu Leu Val His Ile Phe Leu Tyr 
    50                  55                  60                  


Val Val Gln Pro Arg Asp Phe Pro Glu Asp Thr Leu Arg Lys Phe Leu 
65                  70                  75                  80  


Gln Lys Ala Tyr Glu Ser Lys Ile Asp Tyr Asp Lys Pro Glu Thr Val 
                85                  90                  95      


Ile Leu Gly Leu Lys Ile Val Tyr Tyr Glu Ala Gly Ile Ile Leu Cys 
            100                 105                 110         


Cys Val Leu Gly Leu Leu Phe Ile Ile Leu Met Pro Leu Val Gly Tyr 
        115                 120                 125             


Phe Phe Cys Met Cys Arg Cys Cys Asn Lys Cys Gly Gly Glu Met His 
    130                 135                 140                 


Gln Arg Gln Lys Glu Asn Gly Pro Phe Leu Arg Lys Cys Phe Ala Ile 
145                 150                 155                 160 


Ser Leu Leu Val Ile Cys Ile Ile Ile Ser Ile Gly Ile Phe Tyr Gly 
                165                 170                 175     


Phe Val Ala Asn His Gln Val Arg Thr Arg Ile Lys Arg Ser Arg Lys 
            180                 185                 190         


Leu Ala Asp Ser Asn Phe Lys Asp Leu Arg Thr Leu Leu Asn Glu Thr 
        195                 200                 205             


Pro Glu Gln Ile Lys Tyr Ile Leu Ala Gln Tyr Asn Thr Thr Lys Asp 
    210                 215                 220                 


Lys Ala Phe Thr Asp Leu Asn Ser Ile Asn Ser Val Leu Gly Gly Gly 
225                 230                 235                 240 


Ile Leu Asp Arg Leu Arg Pro Asn Ile Ile Pro Val Leu Asp Glu Ile 
                245                 250                 255     


Lys Ser Met Ala Thr Ala Ile Lys Glu Thr Lys Glu Ala Leu Glu Asn 
            260                 265                 270         


Met Asn Ser Thr Leu Lys Ser Leu His Gln Gln Ser Thr Gln Leu Ser 
        275                 280                 285             


Ser Ser Leu Thr Ser Val Lys Thr Ser Leu Arg Ser Ser Leu Asn Asp 
    290                 295                 300                 


Pro Leu Cys Leu Val His Pro Ser Ser Glu Thr Cys Asn Ser Ile Arg 
305                 310                 315                 320 


Leu Ser Leu Ser Gln Leu Asn Ser Asn Pro Glu Leu Arg Gln Leu Pro 
                325                 330                 335     


Pro Val Asp Ala Glu Leu Asp Asn Val Asn Asn Val Leu Arg Thr Asp 
            340                 345                 350         


Leu Asp Gly Leu Val Gln Gln Gly Tyr Gln Ser Leu Asn Asp Ile Pro 
        355                 360                 365             


Asp Arg Val Gln Arg Gln Thr Thr Thr Val Val Ala Gly Ile Lys Arg 
    370                 375                 380                 


Val Leu Asn Ser Ile Gly Ser Asp Ile Asp Asn Val Thr Gln Arg Leu 
385                 390                 395                 400 


Pro Ile Gln Asp Ile Leu Ser Ala Phe Ser Val Tyr Val Asn Asn Thr 
                405                 410                 415     


Glu Ser Tyr Ile His Arg Asn Leu Pro Thr Leu Glu Glu Tyr Asp Ser 
            420                 425                 430         


Tyr Trp Trp Leu Gly Gly Leu Val Ile Cys Ser Leu Leu Thr Leu Ile 
        435                 440                 445             


Val Ile Phe Tyr Tyr Leu Gly Leu Leu Cys Gly Val Cys Gly Tyr Asp 
    450                 455                 460                 


Arg His Ala Thr Pro Thr Thr Arg Gly Cys Val Ser Asn Thr Gly Gly 
465                 470                 475                 480 


Val Phe Leu Met Val Gly Val Gly Leu Ser Phe Leu Phe Cys Trp Ile 
                485                 490                 495     


Leu Met Ile Ile Val Val Leu Thr Phe Val Phe Gly Ala Asn Val Glu 
            500                 505                 510         


Lys Leu Ile Cys Glu Pro Tyr Thr Ser Lys Glu Leu Phe Arg Val Leu 
        515                 520                 525             


Asp Thr Pro Tyr Leu Leu Asn Glu Asp Trp Glu Tyr Tyr Leu Ser Gly 
    530                 535                 540                 


Lys Leu Phe Asn Lys Ser Lys Met Lys Leu Thr Phe Glu Gln Val Tyr 
545                 550                 555                 560 


Ser Asp Cys Lys Lys Asn Arg Gly Thr Tyr Gly Thr Leu His Leu Gln 
                565                 570                 575     


Asn Ser Phe Asn Ile Ser Glu His Leu Asn Ile Asn Glu His Thr Gly 
            580                 585                 590         


Ser Ile Ser Ser Glu Leu Glu Ser Leu Lys Val Asn Leu Asn Ile Phe 
        595                 600                 605             


Leu Leu Gly Ala Ala Gly Arg Lys Asn Leu Gln Asp Phe Ala Ala Cys 
    610                 615                 620                 


Gly Ile Asp Arg Met Asn Tyr Asp Ser Tyr Leu Ala Gln Thr Gly Lys 
625                 630                 635                 640 


Ser Pro Ala Gly Val Asn Leu Leu Ser Phe Ala Tyr Asp Leu Glu Ala 
                645                 650                 655     


Lys Ala Asn Ser Leu Pro Pro Gly Asn Leu Arg Asn Ser Leu Lys Arg 
            660                 665                 670         


Asp Ala Gln Thr Ile Lys Thr Ile His Gln Gln Arg Val Leu Pro Ile 
        675                 680                 685             


Glu Gln Ser Leu Ser Thr Leu Tyr Gln Ser Val Lys Ile Leu Gln Arg 
    690                 695                 700                 


Thr Gly Asn Gly Leu Leu Glu Arg Val Thr Arg Ile Leu Ala Ser Leu 
705                 710                 715                 720 


Asp Phe Ala Gln Asn Phe Ile Thr Asn Asn Thr Ser Ser Val Ile Ile 
                725                 730                 735     


Glu Glu Thr Lys Lys Tyr Gly Arg Thr Ile Ile Gly Tyr Phe Glu His 
            740                 745                 750         


Tyr Leu Gln Trp Ile Glu Phe Ser Ile Ser Glu Lys Val Ala Ser Cys 
        755                 760                 765             


Lys Pro Val Ala Thr Ala Leu Asp Thr Ala Val Asp Val Phe Leu Cys 
    770                 775                 780                 


Ser Tyr Ile Ile Asp Pro Leu Asn Leu Phe Trp Phe Gly Ile Gly Lys 
785                 790                 795                 800 


Ala Thr Val Phe Leu Leu Pro Ala Leu Ile Phe Ala Val Lys Leu Ala 
                805                 810                 815     


Lys Tyr Tyr Arg Arg Met Asp Ser Glu Asp Val Tyr Asp Asp Val Glu 
            820                 825                 830         


Thr Ile Pro Met Lys Asn Met Glu Asn Gly Asn Asn Gly Tyr His Lys 
        835                 840                 845             


Asp His Val Tyr Gly Ile His Asn Pro Val Met Thr Ser Pro Ser Gln 
    850                 855                 860                 


His 
865 


<210>  263
<211>  451
<212>  PRT
<213>  Homo sapiens

<400>  263

Met Ala Thr Met Val Pro Ser Val Leu Trp Pro Arg Ala Cys Trp Thr 
1               5                   10                  15      


Leu Leu Val Cys Cys Leu Leu Thr Pro Gly Val Gln Gly Gln Glu Phe 
            20                  25                  30          


Leu Leu Arg Val Glu Pro Gln Asn Pro Val Leu Ser Ala Gly Gly Ser 
        35                  40                  45              


Leu Phe Val Asn Cys Ser Thr Asp Cys Pro Ser Ser Glu Lys Ile Ala 
    50                  55                  60                  


Leu Glu Thr Ser Leu Ser Lys Glu Leu Val Ala Ser Gly Met Gly Trp 
65                  70                  75                  80  


Ala Ala Phe Asn Leu Ser Asn Val Thr Gly Asn Ser Arg Ile Leu Cys 
                85                  90                  95      


Ser Val Tyr Cys Asn Gly Ser Gln Ile Thr Gly Ser Ser Asn Ile Thr 
            100                 105                 110         


Val Tyr Arg Leu Pro Glu Arg Val Glu Leu Ala Pro Leu Pro Pro Trp 
        115                 120                 125             


Gln Pro Val Gly Gln Asn Phe Thr Leu Arg Cys Gln Val Glu Asp Gly 
    130                 135                 140                 


Ser Pro Arg Thr Ser Leu Thr Val Val Leu Leu Arg Trp Glu Glu Glu 
145                 150                 155                 160 


Leu Ser Arg Gln Pro Ala Val Glu Glu Pro Ala Glu Val Thr Ala Thr 
                165                 170                 175     


Val Leu Ala Ser Arg Asp Asp His Gly Ala Pro Phe Ser Cys Arg Thr 
            180                 185                 190         


Glu Leu Asp Met Gln Pro Gln Gly Leu Gly Leu Phe Val Asn Thr Ser 
        195                 200                 205             


Ala Pro Arg Gln Leu Arg Thr Phe Gly Phe Leu Gly Pro Ile Val Asn 
    210                 215                 220                 


Leu Ser Glu Pro Thr Ala His Glu Gly Ser Thr Val Thr Val Ser Cys 
225                 230                 235                 240 


Met Ala Gly Ala Arg Val Gln Val Thr Leu Asp Gly Val Pro Ala Ala 
                245                 250                 255     


Ala Pro Gly Gln Pro Ala Gln Leu Gln Leu Asn Ala Thr Glu Ser Asp 
            260                 265                 270         


Asp Gly Arg Ser Phe Phe Cys Ser Ala Thr Leu Glu Val Asp Gly Glu 
        275                 280                 285             


Phe Leu His Arg Asn Ser Ser Val Gln Leu Arg Val Leu Tyr Gly Pro 
    290                 295                 300                 


Lys Ile Asp Arg Ala Thr Cys Pro Gln His Leu Lys Trp Lys Asp Lys 
305                 310                 315                 320 


Thr Arg His Val Leu Gln Cys Gln Ala Arg Gly Asn Pro Tyr Pro Glu 
                325                 330                 335     


Leu Arg Cys Leu Lys Glu Gly Ser Ser Arg Glu Val Pro Val Gly Ile 
            340                 345                 350         


Pro Phe Phe Val Asn Val Thr His Asn Gly Thr Tyr Gln Cys Gln Ala 
        355                 360                 365             


Ser Ser Ser Arg Gly Lys Tyr Thr Leu Val Val Val Met Asp Ile Glu 
    370                 375                 380                 


Ala Gly Ser Ser His Phe Val Pro Val Phe Val Ala Val Leu Leu Thr 
385                 390                 395                 400 


Leu Gly Val Val Thr Ile Val Leu Ala Leu Met Tyr Val Phe Arg Glu 
                405                 410                 415     


His Gln Arg Ser Gly Ser Tyr His Val Arg Glu Glu Ser Thr Tyr Leu 
            420                 425                 430         


Pro Leu Thr Ser Met Gln Pro Thr Glu Ala Met Gly Glu Glu Pro Ser 
        435                 440                 445             


Arg Ala Glu 
    450     


