                               SEQUENCE LISTING

<110> ZYMERGEN INC.
 
<120> BIOREACHABLE PREDICTION TOOL WITH BIOLOGICAL SEQUENCE SELECTION

<130> ZYM011WOPC01

<140>
<141>

<150> 62/720,811
<151> 2018-08-21

<150> 62/764,819
<151> 2018-08-15

<150> 62/764,861
<151> 2018-08-15

<160> 10    

<170> PatentIn version 3.5

<210> 1
<211> 497
<212> PRT
<213> Oryza sativa

<400> 1
Met Glu Gly Val Gly Gly Gly Gly Gly Gly Glu Glu Trp Leu Arg Pro 
1               5                   10                  15      


Met Asp Ala Glu Gln Leu Arg Glu Cys Gly His Arg Met Val Asp Phe 
            20                  25                  30          


Val Ala Asp Tyr Tyr Lys Ser Ile Glu Ala Phe Pro Val Leu Ser Gln 
        35                  40                  45              


Val Gln Pro Gly Tyr Leu Lys Glu Val Leu Pro Asp Ser Ala Pro Arg 
    50                  55                  60                  


Gln Pro Asp Thr Leu Asp Ser Leu Phe Asp Asp Ile Gln Gln Lys Ile 
65                  70                  75                  80  


Ile Pro Gly Val Thr His Trp Gln Ser Pro Asn Tyr Phe Ala Tyr Tyr 
                85                  90                  95      


Pro Ser Asn Ser Ser Thr Ala Gly Phe Leu Gly Glu Met Leu Ser Ala 
            100                 105                 110         


Ala Phe Asn Ile Val Gly Phe Ser Trp Ile Thr Ser Pro Ala Ala Thr 
        115                 120                 125             


Glu Leu Glu Val Ile Val Leu Asp Trp Phe Ala Lys Met Leu Gln Leu 
    130                 135                 140                 


Pro Ser Gln Phe Leu Ser Thr Ala Leu Gly Gly Gly Val Ile Gln Gly 
145                 150                 155                 160 


Thr Ala Ser Glu Ala Val Leu Val Ala Leu Leu Ala Ala Arg Asp Arg 
                165                 170                 175     


Ala Leu Lys Lys His Gly Lys His Ser Leu Glu Lys Leu Val Val Tyr 
            180                 185                 190         


Ala Ser Asp Gln Thr His Ser Ala Leu Gln Lys Ala Cys Gln Ile Ala 
        195                 200                 205             


Gly Ile Phe Ser Glu Asn Val Arg Val Val Ile Ala Asp Cys Asn Lys 
    210                 215                 220                 


Asn Tyr Ala Val Ala Pro Glu Ala Val Ser Glu Ala Leu Ser Ile Asp 
225                 230                 235                 240 


Leu Ser Ser Gly Leu Ile Pro Phe Phe Ile Cys Ala Thr Val Gly Thr 
                245                 250                 255     


Thr Ser Ser Ser Ala Val Asp Pro Leu Pro Glu Leu Gly Gln Ile Ala 
            260                 265                 270         


Lys Ser Asn Asp Met Trp Phe His Ile Asp Ala Ala Tyr Ala Gly Ser 
        275                 280                 285             


Ala Cys Ile Cys Pro Glu Tyr Arg His His Leu Asn Gly Val Glu Glu 
    290                 295                 300                 


Ala Asp Ser Phe Asn Met Asn Ala His Lys Trp Phe Leu Thr Asn Phe 
305                 310                 315                 320 


Asp Cys Ser Leu Leu Trp Val Lys Asp Arg Ser Phe Leu Ile Gln Ser 
                325                 330                 335     


Leu Ser Thr Asn Pro Glu Phe Leu Lys Asn Lys Ala Ser Gln Ala Asn 
            340                 345                 350         


Ser Val Val Asp Phe Lys Asp Trp Gln Ile Pro Leu Gly Arg Arg Phe 
        355                 360                 365             


Arg Ser Leu Lys Leu Trp Met Val Leu Arg Leu Tyr Gly Val Asp Asn 
    370                 375                 380                 


Leu Gln Ser Tyr Ile Arg Lys His Ile His Leu Ala Glu His Phe Glu 
385                 390                 395                 400 


Gln Leu Leu Leu Ser Asp Ser Arg Phe Glu Val Val Thr Pro Arg Thr 
                405                 410                 415     


Phe Ser Leu Val Cys Phe Arg Leu Val Pro Pro Thr Ser Asp His Glu 
            420                 425                 430         


Asn Gly Arg Lys Leu Asn Tyr Asp Met Met Asp Gly Val Asn Ser Ser 
        435                 440                 445             


Gly Lys Ile Phe Leu Ser His Thr Val Leu Ser Gly Lys Phe Val Leu 
    450                 455                 460                 


Arg Phe Ala Val Gly Ala Pro Leu Thr Glu Glu Arg His Val Asp Ala 
465                 470                 475                 480 


Ala Trp Lys Leu Leu Arg Asp Glu Ala Thr Lys Val Leu Gly Lys Met 
                485                 490                 495     


Val 
    


<210> 2
<211> 575
<212> PRT
<213> Modestobacter marinus

<400> 2
Met Thr Gly His Met Thr Pro Glu Gln Phe Arg Gln His Gly His Glu 
1               5                   10                  15      


Val Val Asp Trp Ile Ala Asp Tyr Trp Glu Arg Ile Gly Ser Phe Pro 
            20                  25                  30          


Val Arg Ser Gln Val Ser Pro Gly Asp Val Arg Ala Ser Leu Pro Pro 
        35                  40                  45              


Thr Ala Pro Glu Gln Gly Glu Pro Phe Ser Ala Val Leu Ala Asp Leu 
    50                  55                  60                  


Asp Arg Val Val Leu Pro Gly Val Thr His Trp Gln His Pro Gly Phe 
65                  70                  75                  80  


Phe Gly Tyr Phe Pro Ala Asn Thr Ser Gly Pro Ser Val Leu Gly Asp 
                85                  90                  95      


Leu Val Ser Ala Gly Leu Gly Val Gln Gly Met Ser Trp Val Thr Ser 
            100                 105                 110         


Pro Ala Ala Thr Glu Leu Glu Gln His Val Met Asp Trp Phe Ala Asp 
        115                 120                 125             


Leu Leu Gly Leu Pro Glu Ser Phe Arg Ser Thr Gly Ser Gly Gly Gly 
    130                 135                 140                 


Val Val Gln Asp Ser Ser Ser Gly Ala Asn Leu Val Ala Leu Leu Ala 
145                 150                 155                 160 


Ala Leu His Arg Ala Ser Lys Gly Ala Thr Leu Arg His Gly Val Arg 
                165                 170                 175     


Pro Glu Asp His Thr Val Tyr Val Ser Ala Glu Thr His Ser Ser Met 
            180                 185                 190         


Glu Lys Ala Ala Arg Ile Ala Gly Leu Gly Thr Asp Ala Ile Arg Ile 
        195                 200                 205             


Val Glu Val Gly Pro Asp Leu Ala Met Asn Pro Arg Ala Leu Ala Gln 
    210                 215                 220                 


Arg Leu Glu Arg Asp Val Ala Arg Gly Tyr Thr Pro Val Leu Val Cys 
225                 230                 235                 240 


Ala Thr Val Gly Thr Thr Ser Thr Thr Ala Ile Asp Pro Leu Ala Glu 
                245                 250                 255     


Leu Gly Pro Ile Cys Gln Gln His Gly Val Trp Leu His Val Asp Ala 
            260                 265                 270         


Ala Tyr Ala Gly Val Ser Ala Val Ala Pro Glu Leu Arg Ala Leu Gln 
        275                 280                 285             


Ala Gly Val Glu Trp Ala Asp Ser Tyr Thr Thr Asp Ala His Lys Trp 
    290                 295                 300                 


Leu Leu Thr Gly Phe Asp Ala Thr Leu Phe Trp Val Ala Asp Arg Ala 
305                 310                 315                 320 


Ala Leu Thr Gly Ala Leu Ser Ile Leu Pro Glu Tyr Leu Arg Asn Ala 
                325                 330                 335     


Ala Thr Asp Thr Gly Ala Val Val Asp Tyr Arg Asp Trp Gln Ile Glu 
            340                 345                 350         


Leu Gly Arg Arg Phe Arg Ala Leu Lys Leu Trp Phe Val Val Arg Trp 
        355                 360                 365             


Tyr Gly Ala Glu Gly Leu Arg Glu His Val Arg Ser His Val Ala Leu 
    370                 375                 380                 


Ala Gln Glu Leu Ala Gly Trp Ala Asp Ala Asp Glu Arg Phe Asp Val 
385                 390                 395                 400 


Ala Ala Pro His Pro Phe Ser Leu Val Cys Leu Arg Pro Arg Trp Ala 
                405                 410                 415     


Pro Gly Ile Asp Ala Asp Val Ala Thr Met Thr Leu Leu Asp Arg Leu 
            420                 425                 430         


Asn Asp Gly Gly Glu Val Phe Leu Thr His Thr Thr Val Asp Gly Ala 
        435                 440                 445             


Ala Val Leu Arg Val Ala Ile Gly Ala Pro Ala Thr Thr Arg Glu His 
    450                 455                 460                 


Val Glu Arg Val Trp Ala Leu Leu Gly Glu Ala His Asp Trp Leu Ala 
465                 470                 475                 480 


Arg Asp Phe Glu Glu Gln Ala Ala Glu Arg Arg Ala Ala Glu Leu Arg 
                485                 490                 495     


Glu Arg Glu Ala Ala Glu Glu Gln Leu Arg Ala Arg Arg Glu Ala Glu 
            500                 505                 510         


Ala Ala Ala Ala Ala Ala Thr Glu Ala Pro Val Glu Pro Ala Ala Glu 
        515                 520                 525             


Glu Pro Glu Gln Leu Val Val Pro Pro Val Glu Val Pro Ala Val Glu 
    530                 535                 540                 


Thr Pro Ala Ala Trp Asp Glu Ser Ala Thr Gln Val Ala Ala Gln Thr 
545                 550                 555                 560 


Asp Leu His Ala Asp Pro Ala Pro Gln Pro Ala Asp Gly Gln Gly 
                565                 570                 575 


<210> 3
<211> 481
<212> PRT
<213> Streptomyces sviceus

<400> 3
Met Pro Asp Leu Glu Pro Asp Glu Phe Arg Arg Gln Gly His Gln Leu 
1               5                   10                  15      


Val Asp Trp Val Ala Arg Tyr Arg Thr Ser Leu Pro Ser Leu His Val 
            20                  25                  30          


Arg Pro Lys Val Val Pro Gly Ser Val Lys Ala Gln Leu Pro Arg Glu 
        35                  40                  45              


Leu Pro Glu Gln Pro Ser Gln Ala Leu Gly Asp Asp Leu Ile Ala Leu 
    50                  55                  60                  


Leu Asn Asp Val Val Val Pro Ser Ser Leu His Trp Gln His Pro Gly 
65                  70                  75                  80  


Phe Phe Gly Tyr Phe Pro Ala Asn Ala Ser Leu Leu Ser Leu Leu Gly 
                85                  90                  95      


Asp Ile Ala Ser Gly Gly Ile Gly Ala Gln Gly Met Leu Trp Ser Thr 
            100                 105                 110         


Ser Pro Ala Gly Thr Glu Ile Glu Gln Val Leu Leu Asp Gly Leu Ala 
        115                 120                 125             


Asp Ala Leu Gly Leu Gly Arg Glu Phe Thr Phe Ala Gly Gly Gly Gly 
    130                 135                 140                 


Gly Ser Leu Gln Asp Ser Ala Ser Ser Ala Ser Leu Ala Ala Leu Leu 
145                 150                 155                 160 


Ala Ala Leu Gln Arg Ser Asn Pro Asp Trp Arg Glu His Gly Val Asp 
                165                 170                 175     


Gly Thr Glu Thr Val Tyr Val Thr Ala Glu Thr His Ser Ser Leu Ala 
            180                 185                 190         


Lys Ala Val Arg Val Ala Gly Leu Gly Ala Arg Ala Leu Arg Ile Val 
        195                 200                 205             


Pro Phe Thr Gln Gly Thr Leu Ser Met Ser Ala Asp Ala Leu Ala Asp 
    210                 215                 220                 


Met Leu Ala Lys Asp Thr Ala Ala Gly Lys Arg Pro Val Met Val Cys 
225                 230                 235                 240 


Pro Thr Val Gly Thr Thr Gly Thr Gly Ala Ile Asp Pro Val Arg Glu 
                245                 250                 255     


Val Ala Leu Ala Ala Arg Thr Tyr Glu Ala Trp Val His Val Asp Ala 
            260                 265                 270         


Ala Trp Ala Gly Val Ala Ala Leu Cys Pro Glu Phe Arg Trp Leu Leu 
        275                 280                 285             


Asp Gly Val Asn Leu Val Asp Ser Phe Cys Thr Asp Ala His Lys Trp 
    290                 295                 300                 


Phe Tyr Thr Ala Phe Asp Ala Ser Phe Met Trp Val Arg Asp Ala Arg 
305                 310                 315                 320 


Ala Leu Pro Thr Ala Leu Ser Ile Thr Pro Glu Tyr Leu Arg Asn Ala 
                325                 330                 335     


Ala Thr Glu Ser Gly Glu Val Ile Asp Tyr Arg Asp Trp Gln Val Pro 
            340                 345                 350         


Leu Gly Arg Arg Met Arg Ala Leu Lys Ile Trp Ser Val Val His Gly 
        355                 360                 365             


Ala Gly Leu Glu Gly Leu Arg Glu Ser Ile Arg Gly His Val Ala Met 
    370                 375                 380                 


Ala Asn Ser Leu Ala Gly Arg Ile Glu Ser Glu Ser Gly Phe Ala Leu 
385                 390                 395                 400 


Ala Thr Pro Pro Ser Leu Ala Leu Val Cys Leu Tyr Leu Val Asp Gln 
                405                 410                 415     


Glu Gly Arg Pro Asp Asp Ala Ala Thr Lys Ala Ala Met Glu Ala Val 
            420                 425                 430         


Asn Ala Glu Gly His Ser Phe Leu Thr His Thr Ser Val Asn Gly His 
        435                 440                 445             


Phe Ala Ile Arg Val Ala Ile Gly Ala Thr Thr Thr Leu Pro Asp His 
    450                 455                 460                 


Ile Asp Thr Leu Trp Asp Ser Leu Cys Lys Ala Ala Arg Gln Ser Gly 
465                 470                 475                 480 


Gly 
    


<210> 4
<211> 470
<212> PRT
<213> Pseudomonas putida

<400> 4
Met Thr Pro Glu Gln Phe Arg Gln Tyr Gly His Gln Leu Ile Asp Leu 
1               5                   10                  15      


Ile Ala Asp Tyr Arg Gln Thr Val Gly Glu Arg Pro Val Met Ala Gln 
            20                  25                  30          


Val Glu Pro Gly Tyr Leu Lys Ala Ala Leu Pro Ala Thr Ala Pro Gln 
        35                  40                  45              


Gln Gly Glu Pro Phe Ala Ala Ile Leu Asp Asp Val Asn Asn Leu Val 
    50                  55                  60                  


Met Pro Gly Leu Ser His Trp Gln His Pro Asp Phe Tyr Gly Tyr Phe 
65                  70                  75                  80  


Pro Ser Asn Gly Thr Leu Ser Ser Val Leu Gly Asp Phe Leu Ser Thr 
                85                  90                  95      


Gly Leu Gly Val Leu Gly Leu Ser Trp Gln Ser Ser Pro Ala Leu Ser 
            100                 105                 110         


Glu Leu Glu Glu Thr Thr Leu Asp Trp Leu Arg Gln Leu Leu Gly Leu 
        115                 120                 125             


Ser Gly Gln Trp Ser Gly Val Ile Gln Asp Thr Ala Ser Thr Ser Thr 
    130                 135                 140                 


Leu Val Ala Leu Ile Ser Ala Arg Glu Arg Ala Thr Asp Tyr Ala Leu 
145                 150                 155                 160 


Val Arg Gly Gly Leu Gln Ala Glu Pro Lys Pro Leu Ile Val Tyr Val 
                165                 170                 175     


Ser Ala His Ala His Ser Ser Val Asp Lys Ala Ala Leu Leu Ala Gly 
            180                 185                 190         


Phe Gly Arg Asp Asn Ile Arg Leu Ile Pro Thr Asp Glu Arg Tyr Ala 
        195                 200                 205             


Leu Arg Pro Glu Ala Leu Gln Ala Ala Ile Glu Gln Asp Leu Ala Ala 
    210                 215                 220                 


Gly Asn Gln Pro Cys Ala Val Val Ala Thr Thr Gly Thr Thr Thr Thr 
225                 230                 235                 240 


Thr Ala Leu Asp Pro Leu Arg Pro Val Gly Glu Ile Ala Gln Ala Asn 
                245                 250                 255     


Gly Leu Trp Leu His Val Asp Ser Ala Met Ala Gly Ser Ala Met Ile 
            260                 265                 270         


Leu Pro Glu Cys Arg Trp Met Trp Asp Gly Ile Glu Leu Ala Asp Ser 
        275                 280                 285             


Val Val Val Asn Ala His Lys Trp Leu Gly Val Ala Phe Asp Cys Ser 
    290                 295                 300                 


Ile Tyr Tyr Val Arg Asp Pro Gln His Leu Ile Arg Val Met Ser Thr 
305                 310                 315                 320 


Asn Pro Ser Tyr Leu Gln Ser Ala Val Asp Gly Glu Val Lys Asn Leu 
                325                 330                 335     


Arg Asp Trp Gly Ile Pro Leu Gly Arg Arg Phe Arg Ala Leu Lys Leu 
            340                 345                 350         


Trp Phe Met Leu Arg Ser Glu Gly Val Asp Ala Leu Gln Ala Arg Leu 
        355                 360                 365             


Arg Arg Asp Leu Asp Asn Ala Gln Trp Leu Ala Gly Gln Val Glu Ala 
    370                 375                 380                 


Ala Ala Glu Trp Glu Val Leu Ala Pro Val Gln Leu Gln Thr Leu Cys 
385                 390                 395                 400 


Ile Arg His Arg Pro Ala Gly Leu Glu Gly Glu Ala Leu Asp Ala His 
                405                 410                 415     


Thr Lys Gly Trp Ala Glu Arg Leu Asn Ala Ser Gly Ala Ala Tyr Val 
            420                 425                 430         


Thr Pro Ala Thr Leu Asp Gly Arg Trp Met Val Arg Val Ser Ile Gly 
        435                 440                 445             


Ala Leu Pro Thr Glu Arg Gly Asp Val Gln Arg Leu Trp Ala Arg Leu 
    450                 455                 460                 


Gln Asp Val Ile Lys Gly 
465                 470 


<210> 5
<211> 384
<212> PRT
<213> Propionibacterium sp.

<400> 5
Met Gly Met Asp Ile Ser Ser Arg Pro Val Glu Trp Ala Ser Leu Ser 
1               5                   10                  15      


Glu Ile Thr Ala Ser Asp Val Ser Phe Glu Gly Gly Ala Ile Phe Asn 
            20                  25                  30          


Ser Ile Cys Thr Arg Pro His Pro Leu Ala Ala Gln Val Met Ala Asp 
        35                  40                  45              


Asn Leu His Leu Asn Ala Gly Asp Gly Arg Leu Phe Pro Ser Val Ala 
    50                  55                  60                  


Arg Cys Glu Ser Glu Ile Thr Asn Phe Leu Gly Gly Leu Met Gly Leu 
65                  70                  75                  80  


Pro Arg Ala Val Gly Met Cys Thr Ser Gly Ala Thr Glu Ala Asn Leu 
                85                  90                  95      


Ile Ala Val His Ser Ala Ile Glu Asn Trp Arg Arg Lys Gly Gly Gln 
            100                 105                 110         


Gly Arg Pro Gln Val Ile Leu Gly Arg Gly Gly His Phe Ser Phe Asp 
        115                 120                 125             


Lys Ile Ser Val Leu Leu Gly Val Glu Leu Val Leu Ala Trp Ser Asp 
    130                 135                 140                 


Ile Asp Thr Leu Lys Val Asp Pro Glu Ser Val Ser Glu Leu Ile Ser 
145                 150                 155                 160 


Pro Arg Thr Ala Leu Ile Val Ala Thr Ala Gly Ser Ser Glu Thr Gly 
                165                 170                 175     


Ala Val Asp Asp Val Glu Trp Leu Ser Arg Val Ala Leu Ser Lys Gly 
            180                 185                 190         


Val Pro Leu His Val Asp Ala Ala Ser Gly Gly Leu Leu Ile Pro Phe 
        195                 200                 205             


Leu Arg Asp Leu Gly Gly Ala Leu Pro Asp Ile Gly Phe Arg Asn Asp 
    210                 215                 220                 


Gly Val Thr Thr Ile Ala Ile Asp Pro His Lys Phe Gly Ser Ala Pro 
225                 230                 235                 240 


Ile Pro Ser Gly His Leu Val Ala Arg Glu Trp Thr Trp Ile Glu Gly 
                245                 250                 255     


Leu Arg Thr Glu Ser His Tyr Gln Gly Thr Ala Arg His Leu Thr Phe 
            260                 265                 270         


Leu Gly Thr Arg Ser Gly Gly Ser Ile Leu Ala Thr Tyr Ala Leu Phe 
        275                 280                 285             


Gly His Leu Gly Glu Lys Gly Leu Arg Gly Met Ala Glu Gln Leu Lys 
    290                 295                 300                 


Ala Leu Arg Ser His Leu Val Asp Arg Leu Arg Lys Ala Gly Ala Thr 
305                 310                 315                 320 


Leu Ala Tyr Val Pro Glu Leu Met Val Val Ala Leu Lys Ala Asp Ser 
                325                 330                 335     


Asp Ala Val Lys Val Leu Glu Arg Arg Gly Ile Phe Thr Ser Tyr Ala 
            340                 345                 350         


Lys Arg Leu Gly Tyr Leu Arg Ile Val Val Gln Leu His Met Ser Glu 
        355                 360                 365             


Gly Gln Val Asp Gly Leu Val Asp Ala Leu Leu Met Glu Gly Ile Val 
    370                 375                 380                 


<210> 6
<211> 361
<212> PRT
<213> Enterococcus faecium

<400> 6
Thr Lys Leu Gln Asn Asn Glu Leu Lys Arg Gly Trp Gly His Ile Val 
1               5                   10                  15      


Ala Asp Gly Ser Leu Ala Asn Leu Glu Gly Leu Trp Tyr Ala Arg Asn 
            20                  25                  30          


Ile Lys Ser Leu Pro Leu Ala Met Lys Glu Val Thr Pro Glu Leu Val 
        35                  40                  45              


Ala Gly Lys Ser Asp Trp Glu Leu Met Asn Leu Ser Thr Glu Glu Ile 
    50                  55                  60                  


Met Asn Leu Leu Asp Ser Val Pro Glu Lys Ile Asp Glu Ile Lys Ala 
65                  70                  75                  80  


His Ser Ala Arg Ser Gly Lys His Leu Glu Lys Leu Gly Lys Trp Leu 
                85                  90                  95      


Val Pro Gln Thr Lys His Tyr Ser Trp Leu Lys Ala Ala Asp Ile Ile 
            100                 105                 110         


Gly Ile Gly Leu Asp Gln Val Ile Pro Val Pro Val Asp His Asn Tyr 
        115                 120                 125             


Arg Met Asp Ile Asn Glu Leu Glu Lys Ile Val Arg Gly Leu Ala Ala 
    130                 135                 140                 


Glu Lys Thr Pro Ile Leu Gly Val Val Gly Val Val Gly Ser Thr Glu 
145                 150                 155                 160 


Glu Gly Ala Ile Asp Gly Ile Asp Lys Ile Val Ala Leu Arg Arg Val 
                165                 170                 175     


Leu Glu Lys Asp Gly Ile Tyr Phe Tyr Leu His Val Asp Ala Ala Tyr 
            180                 185                 190         


Gly Gly Tyr Gly Arg Ala Ile Phe Leu Asp Glu Asp Asn Asn Phe Ile 
        195                 200                 205             


Pro Phe Glu Asp Leu Lys Asp Val His Tyr Lys Tyr Asn Val Phe Thr 
    210                 215                 220                 


Glu Asn Lys Asp Tyr Ile Leu Glu Glu Val His Ser Ala Tyr Lys Ala 
225                 230                 235                 240 


Ile Glu Glu Ala Glu Ser Val Thr Ile Asp Pro His Lys Met Gly Tyr 
                245                 250                 255     


Val Pro Tyr Ser Ala Gly Gly Ile Val Ile Lys Asp Ile Arg Met Arg 
            260                 265                 270         


Asp Val Ile Ser Tyr Phe Ala Thr Tyr Val Phe Glu Lys Gly Ala Asp 
        275                 280                 285             


Ile Pro Ala Leu Leu Gly Ala Tyr Ile Leu Glu Gly Ser Lys Ala Gly 
    290                 295                 300                 


Ala Thr Ala Ala Ser Val Trp Ala Ala His His Val Leu Pro Leu Asn 
305                 310                 315                 320 


Val Thr Gly Tyr Gly Lys Leu Met Gly Ala Ser Ile Glu Gly Ala His 
                325                 330                 335     


Arg Phe Tyr Asn Phe Leu Lys Asp Leu Ser Phe Lys Val Gly Thr Lys 
            340                 345                 350         


Asn Arg Ser Ser Ser Ile Thr Thr His 
        355                 360     


<210> 7
<211> 363
<212> PRT
<213> Methanosphaerula palustris

<400> 7
Met Leu Asn Lys Gly Leu Ala Glu Glu Glu Leu Phe Ser Phe Leu Ser 
1               5                   10                  15      


Lys Lys Arg Glu Glu Asp Leu Cys His Ser His Ile Leu Ser Ser Met 
            20                  25                  30          


Cys Thr Val Pro His Pro Ile Ala Val Lys Ala His Leu Met Phe Met 
        35                  40                  45              


Glu Thr Asn Leu Gly Asp Pro Gly Leu Phe Pro Gly Thr Ala Ser Leu 
    50                  55                  60                  


Glu Arg Leu Leu Ile Glu Arg Leu Gly Asp Leu Phe His His Arg Glu 
65                  70                  75                  80  


Ala Gly Gly Tyr Ala Thr Ser Gly Gly Thr Glu Ser Asn Ile Gln Ala 
                85                  90                  95      


Leu Arg Ile Ala Lys Ala Gln Lys Lys Val Asp Lys Pro Asn Val Val 
            100                 105                 110         


Ile Pro Glu Thr Ser His Phe Ser Phe Lys Lys Ala Cys Asp Ile Leu 
        115                 120                 125             


Gly Ile Gln Met Lys Thr Val Pro Ala Asp Arg Ser Met Arg Thr Asp 
    130                 135                 140                 


Ile Ser Glu Val Ser Asp Ala Ile Asp Lys Asn Thr Ile Ala Leu Val 
145                 150                 155                 160 


Gly Ile Ala Gly Ser Thr Glu Tyr Gly Met Val Asp Asp Ile Gly Ala 
                165                 170                 175     


Leu Ala Thr Ile Ala Glu Glu Glu Asp Leu Tyr Leu His Val Asp Ala 
            180                 185                 190         


Ala Phe Gly Gly Leu Val Ile Pro Phe Leu Pro Asn Pro Pro Ala Phe 
        195                 200                 205             


Asp Phe Ala Leu Pro Gly Val Ser Ser Ile Ala Val Asp Pro His Lys 
    210                 215                 220                 


Met Gly Met Ser Thr Leu Pro Ala Gly Ala Leu Leu Val Arg Glu Pro 
225                 230                 235                 240 


Gln Met Leu Gly Leu Leu Asn Ile Asp Thr Pro Tyr Leu Thr Val Lys 
                245                 250                 255     


Gln Glu Tyr Thr Leu Ala Gly Thr Arg Pro Gly Ala Ser Val Ala Gly 
            260                 265                 270         


Ala Leu Ala Val Leu Asp Tyr Met Gly Arg Asp Gly Met Glu Ala Val 
        275                 280                 285             


Val Ala Gly Cys Met Lys Asn Thr Ser Arg Leu Ile Arg Gly Met Glu 
    290                 295                 300                 


Thr Leu Gly Phe Pro Arg Ala Val Thr Pro Asp Val Asn Val Ala Thr 
305                 310                 315                 320 


Phe Ile Thr Asn His Pro Ala Pro Lys Asn Trp Val Val Ser Gln Thr 
                325                 330                 335     


Arg Arg Gly His Met Arg Ile Ile Cys Met Pro His Val Thr Ala Asp 
            340                 345                 350         


Met Ile Glu Gln Phe Leu Ile Asp Ile Gly Glu 
        355                 360             


<210> 8
<211> 432
<212> PRT
<213> Petroselinum crispum

<400> 8
Glu Phe Arg Arg Gln Gly His Leu Met Ile Asp Phe Leu Ala Asp Tyr 
1               5                   10                  15      


Tyr Arg Lys Val Glu Asn Tyr Pro Val Arg Ser Gln Val Ser Pro Gly 
            20                  25                  30          


Tyr Leu Arg Glu Ile Leu Pro Glu Ser Ala Pro Tyr Asn Pro Glu Ser 
        35                  40                  45              


Leu Glu Thr Ile Leu Gln Asp Val Gln Thr Lys Ile Ile Pro Gly Ile 
    50                  55                  60                  


Thr His Trp Gln Ser Pro Asn Phe Phe Ala Tyr Phe Pro Ser Ser Gly 
65                  70                  75                  80  


Ser Thr Ala Gly Phe Leu Gly Glu Met Leu Ser Thr Gly Phe Asn Val 
                85                  90                  95      


Val Gly Phe Asn Trp Met Val Ser Pro Ala Ala Thr Glu Leu Glu Asn 
            100                 105                 110         


Val Val Thr Asp Trp Phe Gly Lys Met Leu Gln Leu Pro Lys Ser Phe 
        115                 120                 125             


Leu Phe Ser Gly Gly Gly Gly Gly Val Leu Gln Gly Thr Thr Cys Glu 
    130                 135                 140                 


Ala Ile Leu Cys Thr Leu Val Ala Ala Arg Asp Lys Asn Leu Arg Gln 
145                 150                 155                 160 


His Gly Met Asp Asn Ile Gly Lys Leu Val Val Tyr Cys Ser Asp Gln 
                165                 170                 175     


Thr His Ser Ala Leu Gln Lys Ala Ala Lys Ile Ala Gly Ile Asp Pro 
            180                 185                 190         


Lys Asn Phe Arg Ala Ile Glu Thr Ser Lys Ser Ser Asn Phe Lys Leu 
        195                 200                 205             


Cys Pro Lys Arg Leu Glu Ser Ala Ile Leu Tyr Asp Leu Gln Asn Gly 
    210                 215                 220                 


Leu Ile Pro Leu Tyr Leu Cys Ala Thr Val Gly Thr Thr Ser Ser Thr 
225                 230                 235                 240 


Thr Val Asp Pro Leu Pro Ala Leu Thr Glu Val Ala Lys Lys Tyr Lys 
                245                 250                 255     


Leu Trp Val His Val Asp Ala Ala Tyr Ala Gly Ser Ala Cys Ile Cys 
            260                 265                 270         


Pro Glu Phe Arg Gln Tyr Leu Asp Gly Val Glu Asn Ala Asp Ser Phe 
        275                 280                 285             


Ser Leu Asn Ala His Lys Trp Phe Leu Thr Thr Leu Asp Cys Cys Cys 
    290                 295                 300                 


Leu Trp Val Arg Asp Pro Ser Ala Leu Ile Lys Ser Leu Ser Thr Tyr 
305                 310                 315                 320 


Pro Glu Phe Leu Lys Asn Asn Ala Ser Glu Thr Asn Lys Val Val Asp 
                325                 330                 335     


Tyr Lys Asp Trp Gln Ile Met Leu Ser Arg Arg Phe Arg Ala Leu Lys 
            340                 345                 350         


Leu Trp Phe Val Leu Arg Ser Tyr Gly Val Gly Gln Leu Arg Glu Phe 
        355                 360                 365             


Ile Arg Gly His Val Gly Met Ala Lys Tyr Phe Glu Gly Leu Val Gly 
    370                 375                 380                 


Met Asp Asn Arg Phe Glu Val Val Ala Pro Arg Leu Phe Ser Met Val 
385                 390                 395                 400 


Cys Phe Arg Ile Lys Pro Ser Ala Met Ile Gly Lys Asn Asp Glu Asp 
                405                 410                 415     


Glu Val Asn Glu Ile Asn Arg Lys Leu Leu Glu Ser Val Asn Asp Ser 
            420                 425                 430         


<210> 9
<211> 396
<212> PRT
<213> Methanocaldococcus jannaschii

<400> 9
Met Arg Asn Met Gln Glu Lys Gly Val Ser Glu Lys Glu Ile Leu Glu 
1               5                   10                  15      


Glu Leu Lys Lys Tyr Arg Ser Leu Asp Leu Lys Tyr Glu Asp Gly Asn 
            20                  25                  30          


Ile Phe Gly Ser Met Cys Ser Asn Val Leu Pro Ile Thr Arg Lys Ile 
        35                  40                  45              


Val Asp Ile Phe Leu Glu Thr Asn Leu Gly Asp Pro Gly Leu Phe Lys 
    50                  55                  60                  


Gly Thr Lys Leu Leu Glu Glu Lys Ala Val Ala Leu Leu Gly Ser Leu 
65                  70                  75                  80  


Leu Asn Asn Lys Asp Ala Tyr Gly His Ile Val Ser Gly Gly Thr Glu 
                85                  90                  95      


Ala Asn Leu Met Ala Leu Arg Cys Ile Lys Asn Ile Trp Arg Glu Lys 
            100                 105                 110         


Arg Arg Lys Gly Leu Ser Lys Asn Glu His Pro Lys Ile Ile Val Pro 
        115                 120                 125             


Ile Thr Ala His Phe Ser Phe Glu Lys Gly Arg Glu Met Met Asp Leu 
    130                 135                 140                 


Glu Tyr Ile Tyr Ala Pro Ile Lys Glu Asp Tyr Thr Ile Asp Glu Lys 
145                 150                 155                 160 


Phe Val Lys Asp Ala Val Glu Asp Tyr Asp Val Asp Gly Ile Ile Gly 
                165                 170                 175     


Ile Ala Gly Thr Thr Glu Leu Gly Thr Ile Asp Asn Ile Glu Glu Leu 
            180                 185                 190         


Ser Lys Ile Ala Lys Glu Asn Asn Ile Tyr Ile His Val Asp Ala Ala 
        195                 200                 205             


Phe Gly Gly Leu Val Ile Pro Phe Leu Asp Asp Lys Tyr Lys Lys Lys 
    210                 215                 220                 


Gly Val Asn Tyr Lys Phe Asp Phe Ser Leu Gly Val Asp Ser Ile Thr 
225                 230                 235                 240 


Ile Asp Pro His Lys Met Gly His Cys Pro Ile Pro Ser Gly Gly Ile 
                245                 250                 255     


Leu Phe Lys Asp Ile Gly Tyr Lys Arg Tyr Leu Asp Val Asp Ala Pro 
            260                 265                 270         


Tyr Leu Thr Glu Thr Arg Gln Ala Thr Ile Leu Gly Thr Arg Val Gly 
        275                 280                 285             


Phe Gly Gly Ala Cys Thr Tyr Ala Val Leu Arg Tyr Leu Gly Arg Glu 
    290                 295                 300                 


Gly Gln Arg Lys Ile Val Asn Glu Cys Met Glu Asn Thr Leu Tyr Leu 
305                 310                 315                 320 


Tyr Lys Lys Leu Lys Glu Asn Asn Phe Lys Pro Val Ile Glu Pro Ile 
                325                 330                 335     


Leu Asn Ile Val Ala Ile Glu Asp Glu Asp Tyr Lys Glu Val Cys Lys 
            340                 345                 350         


Lys Leu Arg Asp Arg Gly Ile Tyr Val Ser Val Cys Asn Cys Val Lys 
        355                 360                 365             


Ala Leu Arg Ile Val Val Met Pro His Ile Lys Arg Glu His Ile Asp 
    370                 375                 380                 


Asn Phe Ile Glu Ile Leu Asn Ser Ile Lys Arg Asp 
385                 390                 395     


<210> 10
<211> 531
<212> PRT
<213> Papaver somniferum

<400> 10
Met Gly Ser Leu Asn Thr Glu Asp Val Leu Glu Asn Ser Ser Ala Phe 
1               5                   10                  15      


Gly Val Thr Asn Pro Leu Asp Pro Glu Glu Phe Arg Arg Gln Gly His 
            20                  25                  30          


Met Ile Ile Asp Phe Leu Ala Asp Tyr Tyr Arg Asp Val Glu Lys Tyr 
        35                  40                  45              


Pro Val Arg Ser Gln Val Glu Pro Gly Tyr Leu Arg Lys Arg Leu Pro 
    50                  55                  60                  


Glu Thr Ala Pro Tyr Asn Pro Glu Ser Ile Glu Thr Ile Leu Gln Asp 
65                  70                  75                  80  


Val Thr Thr Glu Ile Ile Pro Gly Leu Thr His Trp Gln Ser Pro Asn 
                85                  90                  95      


Tyr Tyr Ala Tyr Phe Pro Ser Ser Gly Ser Val Ala Gly Phe Leu Gly 
            100                 105                 110         


Glu Met Leu Ser Thr Gly Phe Asn Val Val Gly Phe Asn Trp Met Ser 
        115                 120                 125             


Ser Pro Ala Ala Thr Glu Leu Glu Ser Val Val Met Asp Trp Phe Gly 
    130                 135                 140                 


Lys Met Leu Asn Leu Pro Glu Ser Phe Leu Phe Ser Gly Ser Gly Gly 
145                 150                 155                 160 


Gly Val Leu Gln Gly Thr Ser Cys Glu Ala Ile Leu Cys Thr Leu Thr 
                165                 170                 175     


Ala Ala Arg Asp Arg Lys Leu Asn Lys Ile Gly Arg Glu His Ile Gly 
            180                 185                 190         


Arg Leu Val Val Tyr Gly Ser Asp Gln Thr His Cys Ala Leu Gln Lys 
        195                 200                 205             


Ala Ala Gln Val Ala Gly Ile Asn Pro Lys Asn Phe Arg Ala Ile Lys 
    210                 215                 220                 


Thr Phe Lys Glu Asn Ser Phe Gly Leu Ser Ala Ala Thr Leu Arg Glu 
225                 230                 235                 240 


Val Ile Leu Glu Asp Ile Glu Ala Gly Leu Ile Pro Leu Phe Val Cys 
                245                 250                 255     


Pro Thr Val Gly Thr Thr Ser Ser Thr Ala Val Asp Pro Ile Ser Pro 
            260                 265                 270         


Ile Cys Glu Val Ala Lys Glu Tyr Glu Met Trp Val His Val Asp Ala 
        275                 280                 285             


Ala Tyr Ala Gly Ser Ala Cys Ile Cys Pro Glu Phe Arg His Phe Ile 
    290                 295                 300                 


Asp Gly Val Glu Glu Ala Asp Ser Phe Ser Leu Asn Ala His Lys Trp 
305                 310                 315                 320 


Phe Phe Thr Thr Leu Asp Cys Cys Cys Leu Trp Val Lys Asp Pro Ser 
                325                 330                 335     


Ala Leu Val Lys Ala Leu Ser Thr Asn Pro Glu Tyr Leu Arg Asn Lys 
            340                 345                 350         


Ala Thr Glu Ser Arg Gln Val Val Asp Tyr Lys Asp Trp Gln Ile Ala 
        355                 360                 365             


Leu Ser Arg Arg Phe Arg Ser Leu Lys Leu Trp Met Val Leu Arg Ser 
    370                 375                 380                 


Tyr Gly Val Thr Asn Leu Arg Asn Phe Leu Arg Ser His Val Lys Met 
385                 390                 395                 400 


Ala Lys Thr Phe Glu Gly Leu Ile Cys Met Asp Gly Arg Phe Glu Ile 
                405                 410                 415     


Thr Val Pro Arg Thr Phe Ala Met Val Cys Phe Arg Leu Leu Pro Pro 
            420                 425                 430         


Lys Thr Ile Lys Val Tyr Asp Asn Gly Val His Gln Asn Gly Asn Gly 
        435                 440                 445             


Val Val Pro Leu Arg Asp Glu Asn Glu Asn Leu Val Leu Ala Asn Lys 
    450                 455                 460                 


Leu Asn Gln Val Tyr Leu Glu Thr Val Asn Ala Thr Gly Ser Val Tyr 
465                 470                 475                 480 


Met Thr His Ala Val Val Gly Gly Val Tyr Met Ile Arg Phe Ala Val 
                485                 490                 495     


Gly Ser Thr Leu Thr Glu Glu Arg His Val Ile Tyr Ala Trp Lys Ile 
            500                 505                 510         


Leu Gln Glu His Ala Asp Leu Ile Leu Gly Lys Phe Ser Glu Ala Asp 
        515                 520                 525             


Phe Ser Ser 
    530     


