                         SEQUENCE LISTING

<110>  H. LEE MOFFITT CANCER CENTER AND RESEARCH INSTITUTE, INC.
 
<120>  STAPLED PEPTIDES AS PYRIN-DOMAIN TARGETED NLRP3 INFLAMMASOME 
       INHIBITORS

<130>  10110-201WO1

<160>  45    

<170>  PatentIn version 3.5

<210>  1
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  X = B=betaA = beta-alanine

<220>
<221>  MISC_FEATURE
<222>  (3)..(3)
<223>  X= S5=(S)-2-(4-pentenyl)alanineS5, the two Xs are also directly 
       connected by a double bond

<220>
<221>  MISC_FEATURE
<222>  (7)..(7)
<223>  X= S5=(S)-2-(4-pentenyl)alanineS5, the two Xs are also directly 
       connected by a double bond

<220>
<221>  MISC_FEATURE
<222>  (8)..(8)
<223>  X =NL = norleucine

<400>  1

Xaa Glu Xaa Lys Lys Phe Xaa Xaa Lys Leu Gly Thr Val 
1               5                   10              


<210>  2
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  X = betaA = beta-alanine

<220>
<221>  MISC_FEATURE
<222>  (9)..(9)
<223>  X = NL = norleucine

<400>  2

Xaa Glu Glu Leu Lys Lys Phe Lys Xaa Lys Leu Gly Thr Val 
1               5                   10                  


<210>  3
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  X = betaA = beta-alanine

<220>
<221>  MISC_FEATURE
<222>  (6)..(6)
<223>  X= S5=(S)-2-(4-pentenyl)alanineS5, the two Xs are also directly 
       connected by a double bond

<220>
<221>  MISC_FEATURE
<222>  (8)..(8)
<223>  X = NL = norleucine

<220>
<221>  MISC_FEATURE
<222>  (10)..(10)
<223>  X= S5=(S)-2-(4-pentenyl)alanineS5, the two Xs are also directly 
       connected by a double bond

<400>  3

Xaa Glu Leu Lys Lys Xaa Lys Xaa Lys Xaa Gly Thr Val 
1               5                   10              


<210>  4
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  X = betaA = beta-alanine

<220>
<221>  MISC_FEATURE
<222>  (3)..(3)
<223>  X= S5=(S)-2-(4-pentenyl)alanineS5, the two Xs are also directly 
       connected by a double bond

<220>
<221>  MISC_FEATURE
<222>  (7)..(7)
<223>  X= S5=(S)-2-(4-pentenyl)alanineS5, the two Xs are also directly 
       connected by a double bond

<220>
<221>  MISC_FEATURE
<222>  (9)..(9)
<223>  X= NL = norleucine

<400>  4

Xaa Glu Xaa Leu Lys Lys Xaa Lys Xaa Lys Leu Gly Thr Val 
1               5                   10                  


<210>  5
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  X = betaA = beta-alanine

<220>
<221>  MISC_FEATURE
<222>  (3)..(3)
<223>  X= S5=(S)-2-(4-pentenyl)alanineS5, the two Xs are also directly 
       connected by a double bond

<220>
<221>  MISC_FEATURE
<222>  (7)..(7)
<223>  X= S5=(S)-2-(4-pentenyl)alanineS5, the two Xs are also directly 
       connected by a double bond

<220>
<221>  MISC_FEATURE
<222>  (9)..(9)
<223>  X= NL = norleucine

<400>  5

Xaa Gln Xaa Leu Lys Lys Xaa Lys Xaa Lys Leu Gly Thr Ala 
1               5                   10                  


<210>  6
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  X = betaA = beta-alanine

<220>
<221>  MISC_FEATURE
<222>  (3)..(3)
<223>  X = S5=(S)-2-(4-pentenyl)alanineS5, the two Xs are also directly 
       connected by a double bond

<220>
<221>  MISC_FEATURE
<222>  (7)..(7)
<223>  X = S5=(S)-2-(4-pentenyl)alanineS5, the two Xs are also directly 
       connected by a double bond

<220>
<221>  MISC_FEATURE
<222>  (9)..(9)
<223>  X = NL = norleucine

<400>  6

Xaa Gln Xaa Leu Lys Lys Xaa Lys Xaa Lys Leu Trp Thr Ala 
1               5                   10                  


<210>  7
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  X = betaA = beta-alanine

<220>
<221>  MISC_FEATURE
<222>  (3)..(3)
<223>  X = S5=(S)-2-(4-pentenyl)alanineS5, the two Xs are also directly 
       connected by a double bond

<220>
<221>  MISC_FEATURE
<222>  (7)..(7)
<223>  X = S5=(S)-2-(4-pentenyl)alanineS5, the two Xs are also directly 
       connected by a double bond

<220>
<221>  MISC_FEATURE
<222>  (9)..(9)
<223>  X = NL = norleucine

<400>  7

Xaa Gln Xaa Leu Lys Lys Xaa Lys Xaa Lys Leu Gln Thr Ala 
1               5                   10                  


<210>  8
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  X = betaA = beta-alanine

<220>
<221>  MISC_FEATURE
<222>  (3)..(3)
<223>  X= S5=(S)-2-(4-pentenyl)alanineS5, the two Xs are also directly 
       connected by a double bond

<220>
<221>  MISC_FEATURE
<222>  (7)..(7)
<223>  X= S5=(S)-2-(4-pentenyl)alanineS5, the two Xs are also directly 
       connected by a double bond

<220>
<221>  MISC_FEATURE
<222>  (9)..(9)
<223>  X= NL = norleucine

<400>  8

Xaa Gln Xaa Leu Lys Lys Xaa Lys Xaa Lys Gln Trp Thr Ala 
1               5                   10                  


<210>  9
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  X = betaA = beta-alanine

<220>
<221>  MISC_FEATURE
<222>  (3)..(3)
<223>  X = S5=(S)-2-(4-pentenyl)alanineS5, the two Xs are also directly 
       connected by a double bond

<220>
<221>  MISC_FEATURE
<222>  (7)..(7)
<223>  X = S5=(S)-2-(4-pentenyl)alanineS5, the two Xs are also directly 
       connected by a double bond

<220>
<221>  MISC_FEATURE
<222>  (9)..(9)
<223>  X = NL = norleucine

<400>  9

Xaa Gln Xaa Leu Lys Lys Xaa Gln Xaa Lys Leu Trp Thr Ala 
1               5                   10                  


<210>  10
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  X = betaA = beta-alanine

<220>
<221>  MISC_FEATURE
<222>  (3)..(3)
<223>  X= S5=(S)-2-(4-pentenyl)alanineS5, the two Xs are also directly 
       connected by a double bond

<220>
<221>  MISC_FEATURE
<222>  (7)..(7)
<223>  X= S5=(S)-2-(4-pentenyl)alanineS5, the two Xs are also directly 
       connected by a double bond

<220>
<221>  MISC_FEATURE
<222>  (9)..(9)
<223>  X= NL = norleucine

<400>  10

Xaa Gln Xaa Leu Arg Lys Xaa Gln Xaa Lys Leu Trp Thr Ala 
1               5                   10                  


<210>  11
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  X = betaA = beta-alanine

<220>
<221>  MISC_FEATURE
<222>  (3)..(3)
<223>  X= S5=(S)-2-(4-pentenyl)alanineS5, the two Xs are also directly 
       connected by a double bond

<220>
<221>  MISC_FEATURE
<222>  (7)..(7)
<223>  X= S5=(S)-2-(4-pentenyl)alanineS5, the two Xs are also directly 
       connected by a double bond

<400>  11

Xaa Gln Xaa Leu Arg Lys Xaa Gln Phe Lys Leu Trp Thr Ala 
1               5                   10                  


<210>  12
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  X = betaA = beta-alanine

<220>
<221>  MISC_FEATURE
<222>  (3)..(3)
<223>  X= S5=(S)-2-(4-pentenyl)alanineS5, the two Xs are also directly 
       connected by a double bond

<220>
<221>  MISC_FEATURE
<222>  (7)..(7)
<223>  X= S5=(S)-2-(4-pentenyl)alanineS5, the two Xs are also directly 
       connected by a double bond

<400>  12

Xaa Gln Xaa Leu Arg Lys Xaa Gln Trp Lys Leu Trp Thr Ala 
1               5                   10                  


<210>  13
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  X = betaA = beta-alanine

<220>
<221>  MISC_FEATURE
<222>  (3)..(3)
<223>  X= S5=(S)-2-(4-pentenyl)alanineS5, the two Xs are also directly 
       connected by a double bond

<220>
<221>  MISC_FEATURE
<222>  (7)..(7)
<223>  X= S5=(S)-2-(4-pentenyl)alanineS5, the two Xs are also directly 
       connected by a double bond

<400>  13

Xaa Gln Xaa Leu Arg Arg Xaa Gln Trp Lys Leu Trp Thr Ala 
1               5                   10                  


<210>  14
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  X = betaA = beta-alanine

<220>
<221>  MISC_FEATURE
<222>  (3)..(3)
<223>  X= S5=(S)-2-(4-pentenyl)alanineS5, the two Xs are also directly 
       connected by a double bond

<220>
<221>  MISC_FEATURE
<222>  (7)..(7)
<223>  X= S5=(S)-2-(4-pentenyl)alanineS5, the two Xs are also directly 
       connected by a double bond

<400>  14

Xaa Gln Xaa Leu Arg Arg Xaa Gln Trp Lys Leu Trp Asn Ala 
1               5                   10                  


<210>  15
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  X = betaA = beta-alanine

<220>
<221>  MISC_FEATURE
<222>  (3)..(3)
<223>  X= S5=(S)-2-(4-pentenyl)alanineS5, the two Xs are also directly 
       connected by a double bond

<220>
<221>  MISC_FEATURE
<222>  (7)..(7)
<223>  X= S5=(S)-2-(4-pentenyl)alanineS5, the two Xs are also directly 
       connected by a double bond

<400>  15

Xaa Gln Xaa Leu Arg Arg Xaa Gln Trp Lys Leu Trp Gln Ala 
1               5                   10                  


<210>  16
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  X = betaA = beta-alanine

<220>
<221>  MISC_FEATURE
<222>  (3)..(3)
<223>  X= S5=(S)-2-(4-pentenyl)alanineS5, the two Xs are also directly 
       connected by a double bond

<220>
<221>  MISC_FEATURE
<222>  (7)..(7)
<223>  X= S5=(S)-2-(4-pentenyl)alanineS5, the two Xs are also directly 
       connected by a double bond

<400>  16

Xaa Gln Xaa Leu Arg Arg Xaa Gln Trp Lys Leu Trp Thr Ser 
1               5                   10                  


<210>  17
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  X = betaA = beta-alanine

<220>
<221>  MISC_FEATURE
<222>  (3)..(3)
<223>  X= S5=(S)-2-(4-pentenyl)alanineS5, the two Xs are also directly 
       connected by a double bond

<220>
<221>  MISC_FEATURE
<222>  (7)..(7)
<223>  X= S5=(S)-2-(4-pentenyl)alanineS5, the two Xs are also directly 
       connected by a double bond

<220>
<221>  MISC_FEATURE
<222>  (10)..(10)
<223>  X= NL = norleucine

<400>  17

Xaa Gln Xaa Leu Arg Arg Xaa Gln Trp Xaa Leu Trp Thr Ala 
1               5                   10                  


<210>  18
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  X = betaA = beta-alanine

<220>
<221>  MISC_FEATURE
<222>  (3)..(3)
<223>  X= S5=(S)-2-(4-pentenyl)alanineS5, the two Xs are also directly 
       connected by a double bond

<220>
<221>  MISC_FEATURE
<222>  (7)..(7)
<223>  X= S5=(S)-2-(4-pentenyl)alanineS5, the two Xs are also directly 
       connected by a double bond

<400>  18

Xaa Gln Xaa Leu Arg Arg Xaa Gln Trp Phe Leu Trp Thr Ala 
1               5                   10                  


<210>  19
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  X = betaA = beta-alanine

<220>
<221>  MISC_FEATURE
<222>  (3)..(3)
<223>  X= S5=(S)-2-(4-pentenyl)alanineS5, the two Xs are also directly 
       connected by a double bond

<220>
<221>  MISC_FEATURE
<222>  (7)..(7)
<223>  X= S5=(S)-2-(4-pentenyl)alanineS5, the two Xs are also directly 
       connected by a double bond

<220>
<221>  MISC_FEATURE
<222>  (9)..(9)
<223>  X = (1-Nal)

<400>  19

Xaa Gln Xaa Leu Arg Arg Xaa Gln Xaa Lys Leu Trp Thr Ala 
1               5                   10                  


<210>  20
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  X = betaA = beta-alanine

<220>
<221>  MISC_FEATURE
<222>  (3)..(3)
<223>  X= S5=(S)-2-(4-pentenyl)alanineS5, the two Xs are also directly 
       connected by a double bond

<220>
<221>  MISC_FEATURE
<222>  (7)..(7)
<223>  X= S5=(S)-2-(4-pentenyl)alanineS5, the two Xs are also directly 
       connected by a double bond

<220>
<221>  MISC_FEATURE
<222>  (9)..(9)
<223>  X = (2-Nal)

<400>  20

Xaa Gln Xaa Leu Arg Arg Xaa Gln Xaa Lys Leu Trp Thr Ala 
1               5                   10                  


<210>  21
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  X = betaA = beta-alanine

<220>
<221>  MISC_FEATURE
<222>  (3)..(3)
<223>  X= S5=(S)-2-(4-pentenyl)alanineS5, the two Xs are also directly 
       connected by a double bond

<220>
<221>  MISC_FEATURE
<222>  (7)..(7)
<223>  X= S5=(S)-2-(4-pentenyl)alanineS5, the two Xs are also directly 
       connected by a double bond

<220>
<221>  MISC_FEATURE
<222>  (9)..(9)
<223>  X = (1-Nal)

<220>
<221>  MISC_FEATURE
<222>  (10)..(10)
<223>  X = NL = norleucine

<400>  21

Xaa Gln Xaa Leu Arg Arg Xaa Gln Xaa Xaa Leu Trp Thr Ala 
1               5                   10                  


<210>  22
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  X = betaA = beta-alanine

<220>
<221>  MISC_FEATURE
<222>  (3)..(3)
<223>  X= S5=(S)-2-(4-pentenyl)alanineS5, the two Xs are also directly 
       connected by a double bond

<220>
<221>  MISC_FEATURE
<222>  (7)..(7)
<223>  X= S5=(S)-2-(4-pentenyl)alanineS5, the two Xs are also directly 
       connected by a double bond

<220>
<221>  MISC_FEATURE
<222>  (9)..(9)
<223>  X= (2-Nal)

<220>
<221>  MISC_FEATURE
<222>  (10)..(10)
<223>  X= NL = norleucine

<400>  22

Xaa Gln Xaa Leu Arg Arg Xaa Gln Xaa Leu Trp Thr Ala 
1               5                   10              


<210>  23
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  X = betaA = beta-alanine

<220>
<221>  MISC_FEATURE
<222>  (3)..(3)
<223>  X= S5=(S)-2-(4-pentenyl)alanineS5, the two Xs are also directly 
       connected by a double bond

<220>
<221>  MISC_FEATURE
<222>  (7)..(7)
<223>  X= S5=(S)-2-(4-pentenyl)alanineS5, the two Xs are also directly 
       connected by a double bond

<220>
<221>  MISC_FEATURE
<222>  (10)..(10)
<223>  X= NL = norleucine

<400>  23

Xaa Gln Xaa Leu Arg Arg Xaa Gln Trp Xaa Arg Trp Thr Ala 
1               5                   10                  


<210>  24
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  X = betaA = beta-alanine

<220>
<221>  MISC_FEATURE
<222>  (3)..(3)
<223>  X= S5=(S)-2-(4-pentenyl)alanineS5, the two Xs are also directly 
       connected by a double bond

<220>
<221>  MISC_FEATURE
<222>  (7)..(7)
<223>  X= S5=(S)-2-(4-pentenyl)alanineS5, the two Xs are also directly 
       connected by a double bond

<220>
<221>  MISC_FEATURE
<222>  (10)..(10)
<223>  X= NL = norleucine

<400>  24

Xaa Gln Xaa Ser Arg Arg Xaa Gln Trp Xaa Arg Trp Thr Ala 
1               5                   10                  


<210>  25
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  X = betaA = beta-alanine

<220>
<221>  MISC_FEATURE
<222>  (3)..(3)
<223>  X= S5=(S)-2-(4-pentenyl)alanineS5, the two Xs are also directly 
       connected by a double bond

<220>
<221>  MISC_FEATURE
<222>  (7)..(7)
<223>  X= S5=(S)-2-(4-pentenyl)alanineS5, the two Xs are also directly 
       connected by a double bond

<220>
<221>  MISC_FEATURE
<222>  (10)..(10)
<223>  X= NL = norleucine

<400>  25

Xaa Gln Xaa Leu Arg Arg Xaa Gln Trp Xaa Gln Trp Thr Ala 
1               5                   10                  


<210>  26
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  X = betaA = beta-alanine

<220>
<221>  MISC_FEATURE
<222>  (3)..(3)
<223>  X= S5=(S)-2-(4-pentenyl)alanineS5, the two Xs are also directly 
       connected by a double bond

<220>
<221>  MISC_FEATURE
<222>  (7)..(7)
<223>  X= S5=(S)-2-(4-pentenyl)alanineS5, the two Xs are also directly 
       connected by a double bond

<220>
<221>  MISC_FEATURE
<222>  (10)..(10)
<223>  X= NL = norleucine

<400>  26

Xaa Gln Xaa Ser Arg Arg Xaa Gln Trp Xaa Gln Trp Thr Ala 
1               5                   10                  


<210>  27
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  X = betaA = beta-alanine

<220>
<221>  MISC_FEATURE
<222>  (3)..(3)
<223>  X= S5=(S)-2-(4-pentenyl)alanineS5, the two Xs are also directly 
       connected by a double bond

<220>
<221>  MISC_FEATURE
<222>  (7)..(7)
<223>  X= S5=(S)-2-(4-pentenyl)alanineS5, the two Xs are also directly 
       connected by a double bond

<220>
<221>  MISC_FEATURE
<222>  (10)..(10)
<223>  X= NL = norleucine

<400>  27

Xaa Gln Xaa Ser Arg Arg Xaa Lys Trp Xaa Gln Trp Thr Ala 
1               5                   10                  


<210>  28
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  X = betaA = beta-alanine

<220>
<221>  MISC_FEATURE
<222>  (3)..(3)
<223>  X= S5=(S)-2-(4-pentenyl)alanineS5, the two Xs are also directly 
       connected by a double bond

<220>
<221>  MISC_FEATURE
<222>  (7)..(7)
<223>  X= S5=(S)-2-(4-pentenyl)alanineS5, the two Xs are also directly 
       connected by a double bond

<220>
<221>  MISC_FEATURE
<222>  (10)..(10)
<223>  X= NL = norleucine

<400>  28

Xaa Gln Xaa Leu Arg Arg Xaa Gln Trp Xaa Leu Gly Thr Ala 
1               5                   10                  


<210>  29
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  X = betaA = beta-alanine

<220>
<221>  MISC_FEATURE
<222>  (3)..(3)
<223>  X= S5=(S)-2-(4-pentenyl)alanineS5, the two Xs are also directly 
       connected by a double bond

<220>
<221>  MISC_FEATURE
<222>  (7)..(7)
<223>  X= S5=(S)-2-(4-pentenyl)alanineS5, the two Xs are also directly 
       connected by a double bond

<220>
<221>  MISC_FEATURE
<222>  (10)..(10)
<223>  X= NL = norleucine

<400>  29

Xaa Gln Xaa Leu Arg Arg Xaa Gln Trp Xaa Leu Asp Thr Ala 
1               5                   10                  


<210>  30
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  X = betaA = beta-alanine

<220>
<221>  MISC_FEATURE
<222>  (3)..(3)
<223>  X= S5=(S)-2-(4-pentenyl)alanineS5, the two Xs are also directly 
       connected by a double bond

<220>
<221>  MISC_FEATURE
<222>  (7)..(7)
<223>  X= S5=(S)-2-(4-pentenyl)alanineS5, the two Xs are also directly 
       connected by a double bond

<220>
<221>  MISC_FEATURE
<222>  (10)..(10)
<223>  X= NL = norleucine

<400>  30

Xaa Gln Xaa Leu Arg Arg Xaa Gln Trp Xaa Leu Asn Thr Ala 
1               5                   10                  


<210>  31
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  X = betaA = beta-alanine

<220>
<221>  MISC_FEATURE
<222>  (3)..(3)
<223>  X= S5=(S)-2-(4-pentenyl)alanineS5, the two Xs are also directly 
       connected by a double bond

<220>
<221>  MISC_FEATURE
<222>  (7)..(7)
<223>  X= S5=(S)-2-(4-pentenyl)alanineS5, the two Xs are also directly 
       connected by a double bond

<220>
<221>  MISC_FEATURE
<222>  (10)..(10)
<223>  X= NL = norleucine

<400>  31

Xaa Gln Xaa Leu Arg Arg Xaa Gln Trp Xaa Leu Ser Thr Ala 
1               5                   10                  


<210>  32
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct


<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  X= S5=(S)-2-(4-pentenyl)alanineS5, the two Xs are also directly 
       connected by a double bond

<220>
<221>  MISC_FEATURE
<222>  (6)..(6)
<223>  X= S5=(S)-2-(4-pentenyl)alanineS5, the two Xs are also directly 
       connected by a double bond

<400>  32

Glu Xaa Lys Lys Phe Xaa Met Lys Leu Gly Thr Val 
1               5                   10          


<210>  33
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct


<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  X = R8 = Fmoc-(R)-2-(7-octenyl)alanine-OH, an O and an X are also
       directly connected by a double bond

<220>
<221>  MISC_FEATURE
<222>  (9)..(9)
<223>  X= S5=(S)-2-(4-pentenyl)alanineS5, the two Xs are also directly 
       connected by a double bond

<400>  33

Glu Xaa Lys Lys Phe Lys Met Lys Xaa Gly Thr Val 
1               5                   10          


<210>  34
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct


<220>
<221>  MISC_FEATURE
<222>  (5)..(5)
<223>  X= S5=(S)-2-(4-pentenyl)alanineS5, the two Xs are also directly 
       connected by a double bond

<220>
<221>  MISC_FEATURE
<222>  (9)..(9)
<223>  X= S5=(S)-2-(4-pentenyl)alanineS5, the two Xs are also directly 
       connected by a double bond

<400>  34

Glu Leu Lys Lys Xaa Lys Met Lys Xaa Gly Thr Val 
1               5                   10          


<210>  35
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct


<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  X= S5=(S)-2-(4-pentenyl)alanineS5, the two Xs are also directly 
       connected by a double bond

<220>
<221>  MISC_FEATURE
<222>  (6)..(6)
<223>  X= S5=(S)-2-(4-pentenyl)alanineS5, the two Xs are also directly 
       connected by a double bond

<400>  35

Glu Xaa Leu Lys Lys Xaa Lys Met Lys Leu Gly Thr Val 
1               5                   10              


<210>  36
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct


<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  X= S5=(S)-2-(4-pentenyl)alanineS5, the two Xs are also directly 
       connected by a double bond

<220>
<221>  MISC_FEATURE
<222>  (6)..(6)
<223>  X= S5=(S)-2-(4-pentenyl)alanineS5, the two Xs are also directly 
       connected by a double bond

<400>  36

Glu Xaa Leu Lys Lys Xaa Lys Trp Lys Leu Gly Thr Ala 
1               5                   10              


<210>  37
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  37

Glu Ser Leu Lys Lys Ser Lys Phe Lys Leu Gly Thr Ala 
1               5                   10              


<210>  38
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct


<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  X= S5=(S)-2-(4-pentenyl)alanineS5, the two Xs are also directly 
       connected by a double bond

<220>
<221>  MISC_FEATURE
<222>  (6)..(6)
<223>  X= S5=(S)-2-(4-pentenyl)alanineS5, the two Xs are also directly 
       connected by a double bond

<400>  38

Glu Xaa Leu Lys Lys Xaa Lys His Lys Leu Gly Thr Ala 
1               5                   10              


<210>  39
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct


<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  X= S5=(S)-2-(4-pentenyl)alanineS5, the two Xs are also directly 
       connected by a double bond

<220>
<221>  MISC_FEATURE
<222>  (6)..(6)
<223>  X= S5=(S)-2-(4-pentenyl)alanineS5, the two Xs are also directly 
       connected by a double bond

<400>  39

Glu Xaa Leu Lys Lys Xaa Lys Glx Lys Leu Gly Thr Ala 
1               5                   10              


<210>  40
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  40

Glu Glu Leu Lys Lys Phe Lys Met Lys Leu Gly Thr Val 
1               5                   10              


<210>  41
<211>  21
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  41

Leu Thr Ala Glu Glu Leu Lys Lys Phe Lys Leu Lys Leu Leu Ser Val 
1               5                   10                  15      


Pro Leu Arg Glu Gly 
            20      


<210>  42
<211>  21
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  42

Leu Glu Asp Val Asp Leu Lys Lys Phe Lys Met His Leu Glu Asp Tyr 
1               5                   10                  15      


Pro Pro Gln Lys Gly 
            20      


<210>  43
<211>  21
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  43

Leu Thr Pro Glu Glu Leu Lys Lys Phe Lys Met Lys Leu Gly Thr Val 
1               5                   10                  15      


Pro Leu Arg Glu Gly 
            20      


<210>  44
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct


<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  X= S5=(S)-2-(4-pentenyl)alanineS5, the two Xs are also directly 
       connected by a double bond

<220>
<221>  MISC_FEATURE
<222>  (6)..(6)
<223>  X= S5=(S)-2-(4-pentenyl)alanineS5, the two Xs are also directly 
       connected by a double bond

<220>
<221>  MISC_FEATURE
<222>  (9)..(9)
<223>  X= NL = norleucine

<400>  44

Gln Xaa Leu Arg Arg Xaa Gln Trp Xaa Leu Trp Thr Ala 
1               5                   10              


<210>  45
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct


<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  X= S5=(S)-2-(4-pentenyl)alanineS5, the two Xs are also directly 
       connected by a double bond

<220>
<221>  MISC_FEATURE
<222>  (6)..(6)
<223>  X= S5=(S)-2-(4-pentenyl)alanineS5, the two Xs are also directly 
       connected by a double bond

<400>  45

Gln Xaa Leu Arg Arg Xaa Gln Trp Phe Leu Trp Thr Ala 
1               5                   10              


