                         SEQUENCE LISTING

<110>  Genentech Inc.
 
<120>  DIAGNOSTIC AND THERAPEUTIC METHODS FOR THE TREATMENT OF BREAST 
       CANCER

<130>  048893-517001WO

<150>  US 62/719,545
<151>  2018-08-17

<160>  90    

<170>  PatentIn version 3.5

<210>  1
<211>  767
<212>  DNA
<213>  Homo sapiens

<400>  1
agaaacatcc agaatacatt tccaacaaga gcactggcca agtcagcttc ttctgagaga       60

gtctctagaa gacatgatgc tacactcagc tttgggtctc tgcctcttac tcgtcacagt      120

ttcttccaac cttgccattg caataaaaaa ggaaaagagg cctcctcaga cactctcaag      180

aggatgggga gatgacatca cttgggtaca aacttatgaa gaaggtctct tttatgctca      240

aaaaagtaag aagccattaa tggttattca tcacctggag gattgtcaat actctcaagc      300

actaaagaaa gtatttgccc aaaatgaaga aatacaagaa atggctcaga ataagttcat      360

catgctaaac cttatgcatg aaaccactga taagaattta tcacctgatg ggcaatatgt      420

gcctagaatc atgtttgtag acccttcttt aacagttaga gctgacatag ctggaagata      480

ctctaacaga ttgtacacat atgagcctcg ggatttaccc ctattgatag aaaacatgaa      540

gaaagcatta agacttattc agtcagagct ataagagatg atggaaaaaa gccttcactt      600

caaagaagtc aaatttcatg aagaaaacct ctggcacatt gacaaatact aaatgtgcaa      660

gtatatagat tttgtaatat tactatttag tttttttaat gtgtttgcaa tagtcttatt      720

aaaataaatg ttttttaaat ctgagactga aaaaaaaaaa aaaaaaa                    767


<210>  2
<211>  166
<212>  PRT
<213>  Homo sapiens

<400>  2

Met Met Leu His Ser Ala Leu Gly Leu Cys Leu Leu Leu Val Thr Val 
1               5                   10                  15      


Ser Ser Asn Leu Ala Ile Ala Ile Lys Lys Glu Lys Arg Pro Pro Gln 
            20                  25                  30          


Thr Leu Ser Arg Gly Trp Gly Asp Asp Ile Thr Trp Val Gln Thr Tyr 
        35                  40                  45              


Glu Glu Gly Leu Phe Tyr Ala Gln Lys Ser Lys Lys Pro Leu Met Val 
    50                  55                  60                  


Ile His His Leu Glu Asp Cys Gln Tyr Ser Gln Ala Leu Lys Lys Val 
65                  70                  75                  80  


Phe Ala Gln Asn Glu Glu Ile Gln Glu Met Ala Gln Asn Lys Phe Ile 
                85                  90                  95      


Met Leu Asn Leu Met His Glu Thr Thr Asp Lys Asn Leu Ser Pro Asp 
            100                 105                 110         


Gly Gln Tyr Val Pro Arg Ile Met Phe Val Asp Pro Ser Leu Thr Val 
        115                 120                 125             


Arg Ala Asp Ile Ala Gly Arg Tyr Ser Asn Arg Leu Tyr Thr Tyr Glu 
    130                 135                 140                 


Pro Arg Asp Leu Pro Leu Leu Ile Glu Asn Met Lys Lys Ala Leu Arg 
145                 150                 155                 160 


Leu Ile Gln Ser Glu Leu 
                165     


<210>  3
<211>  5531
<212>  DNA
<213>  Homo sapiens

<400>  3
gattggtgct gtgacctgcg gcagcacagc cgcctgcgtt gagcgcccac ggtgggctgg       60

actttgcact aggtgctgac aggaccggca gaggtggcca ctgccctcgt ccccagcctg      120

cactcctggg cgaaggctga cgctgaacag ggtgctgtgg gcccagaagc gcccatgcct      180

gagagcgtcc aggaccaggc agagctgggc cttaagggcc cttggaccag tgtctgtctg      240

cagggagccc ccggtagcca ctcggatcag cccgagggaa gattctggac gagaccgtgg      300

ccgtcccccg ggtggcccat ggacagcagc aggggctccc aggagtggcc aggccctgcc      360

cgcccaccat gctgcagtgt agacccgcac aggagttcag cttcgggccc cgggccttga      420

aggacgctct ggtctccact gacgcagccc tgcagcagct gtatgtgtcc gccttctccc      480

ctgccgagcg gctcttcctg gccgaggcct acaacccgca gaggacgctc ttctgcaccc      540

tgctcatccg cacgggcttc gactggctcc tgagccgacc cgaggctccc gaggacttcc      600

agaccttcca cgcctccctg cagcaccgga agccccgcct ggctcggaag cacatctacc      660

tacagccgat agacctgagc gaggagccgg tgggaagctc cctgctgcac cagctgtgca      720

gctgcacaga ggccttcttc ctgggcctgc gcgtcaagtg cctgccgtcg gtggcagccg      780

cgtccatccg ctgctcctcg cggcccagcc gggactctga caggctccag ctccacacag      840

acggcatcct gtccttcttg aagaacaaca agccagggga cgcgctgtgt gtgctgggcc      900

tcacactgtc tgacctgtac ccccatgagg cctggagctt caccttcagc aagttccttc      960

cagggcacga agtgggcgtc tgcagcttcg cccggttctc aggggaattc ccgaagtcgg     1020

ggcccagcgc ccctgatctg gccctggtag aggcagcagc agacggcccc gaggcccccc     1080

tgcaggacag gggctgggcc ctgtgcttca gtgccctggg gatggttcag tgctgcaagg     1140

tcacgtgcca cgagctctgc caccttctgg gcctggggaa ctgccgctgg ctccgctgcc     1200

tcatgcaggg tgcgctcagc ctggacgagg ccctgcggcg gcccctggac ctctgtccca     1260

tctgcctgag gaagctgcag catgtcctgg gtttcaggct catcgagagg taccagagac     1320

tctacacctg gactcaggcg gtggtgggga cgtggcccag ccaggaggcg ggggagccgt     1380

cagtgtggga ggacaccccg cctgccagcg ccgactcggg catgtgctgt gagagtgact     1440

cggagcccgg caccagtgtg tcggagcccc tcacccctga tgccgggagt cacaccttcg     1500

cctcggggcc agaggaaggg ctgagctacc tggcagcctc agaggctccg ctgccacctg     1560

ggggccctgc ggaggccatc aaggagcatg aacggtggct ggccatgtgc atccaggccc     1620

tgcagcggga agtggcagag gaggacctgg tgcaggtgga cagagccgtg gacgccctcg     1680

accgctggga gatgttcacg ggccagctcc cggccaccag gcaggaccca cccagcagca     1740

gggacagcgt ggggctgcgc aaggtgctgg gggacaagtt ctcctccctg aggaggaagc     1800

tgagtgcccg aaaactcgcc agagcagagt cggccccccg tccctgggat ggggaagaga     1860

gttagtacag caggggctgc cctacgtctc cttccctaag gatgctggcc agcactgtcc     1920

agtagctgag gccactactg acctgccagg gataaagagg aagggtctgc ctgggtggtg     1980

gctcaggcct gtcatcccat cactttgaga ggccaggagt ttgagaccag actgggcaac     2040

atggtgagac tctgcctcta caaaagaaaa attaaaaaat tagctggatg aagtggttca     2100

tgcctgtgtt cccagctatt caggaggctg aggtgggagg attgcttgag cctaggaggt     2160

cgaggctgca gtgggatgtg atcataccac tgtactgcag tctgggccac acagaaagac     2220

tgtctccaga aaaaaaaaag ttctttggag aagccacaga ccacctgtct tcaggcgcct     2280

ccttcaactc ctgagtccca gccagccgct cccaggggcc tgcacacatg gagaggcctc     2340

cctgatcctg ggtgcttctc gtggagtaca agccggactg tgctgaggtt gggacagagc     2400

cccctcccct gcagaggcag aaggaagcag cgtgcgtcct gtctccttcc aggctgtggg     2460

cctgcccttc agttatttat agctggagct ggagaggctg gctcagatga ggagtgaccc     2520

cgggggcaca caggctccac actgccaccc agcttccaag gctgagtctc ctccctaacg     2580

gggaagtgac ggggttttgt ctctatcatc tcaggcgtca accacatgca cacacacact     2640

gtcacgttct gtggcgctaa cagcatcctg atcctgacgg acttcaccgg ggctctccag     2700

gcatctcttc tgacaaacac tgcaggaggt gagggtgtct gacgtgcact gagggcagag     2760

gcccccttat tcctgaggcg gctacagctc accgtgggga agatcaactg tggtgatgtt     2820

tttgggacag tttcttggca aaggtggccg cgctgtcagt accaagtagc tggaggtggt     2880

gatcagatga tctgtctttc cttttttttt cggtctagtt ctgtcagttg ctgagagagg     2940

ggtattattg ccatggctgg gcgtttgatc tgtctccctt tagttttgcc ggattttgct     3000

tcctgcactt tgaagctcct ttacgtccct gcacatttga ttgttgtgtc ttcctgagga     3060

attgaccctt ttattgtcac acgtaccccc tcagcctgtg gtggagggtc tctgggagag     3120

agacttccgg ttctgacagc ggaatccctt cggagtgacg agggcggggt cacagctcgc     3180

gcaccctcat ctggagagag gcaagaacag ggcagcttgg accttttgtg ggtgggtggc     3240

tcacacggtt atggagggct tctaagaaaa acaaaataca aaactaaaac tagaagggct     3300

atgcaggtga ggtgggctga ggcttccttg tgaatctgac attggtggag gccgactgaa     3360

ggctcccggt cctggtccca ctccgtgttg acttcagaga agcaaagatg cagctcagaa     3420

gtagcattag gatcttcgtc ccgttctctt ttgcgtagct tcaaaaaggc gtaacagtga     3480

cctgggaggg gagatgaaga gctaggcctt tcagaaagtg accaatggaa ggtgccggca     3540

gagcaccctg cagtaacaga aggtgaaagc cggagcctgg tggctgttgc tgcaaacaac     3600

cacccaaaac ttagtggctt aaaatcacca cagtctagct catgaatctg taacttgggc     3660

agagctcggt ggagacggtt tgcccctgtg gctcgactgg agtgttcgtt cacacggctg     3720

ccaagtggaa tttggctggg aatctcaggc cttggttcct gcccacgtga gactctccat     3780

ggaggagggg catcttctta ggaaggcagc tgccataccg tgaggaaacc cgacaaacag     3840

ggcagccaga gccagacagc aggctcctgg tcccagtccc ggaaaatgca aagggacaag     3900

tatgtgttga tttcagagaa gctcagatgt agcattagga ccttcatcca tacccttctc     3960

ttttgcatgg cttctaaagg gcatgacagt gacctgggag gtaactgtgc cagaataaag     4020

aggggagacg aaaaaaagag ggtcactttc agaaagggac ctgggcttcc tcacaatatg     4080

gcggttgccc tcctaaggtg gacatcggga gggtcagatg gaagctctgt ggcctttcct     4140

aactcggcct cacgtcacag agcgtcacct ttcctgcact ccacggcggc agtgacaagg     4200

accccacccc aggttcacgg ggaggggacg tggcagggaa tgtgagacaa cacaatattg     4260

ctgtggccat tcatgaacag tcagtcagcc ccactcggcg ttcactgtgg ggatttggct     4320

ggtgcacctg cgaggtggcc tgacctgttt tccgatttcc ttcatcttct gcaaaaggtt     4380

aaccgctgga gtgatgcgag attaaacaga ggtgataaaa atagaatgcc tggctcatgc     4440

tgagggtggg agcccactgg ggttatgacc aaagcctcgg cgctctctgt acccgtgtcc     4500

tttgaccctc agctgtgatg tgtgtcccaa aaaagcgttt tgaagtggga aggagcaaac     4560

cactaaaaaa aactcctttt atccgcagcg tttaccaact tgcagatgtc agtgaaattt     4620

tttaagacag ctgttagaag gactgttttg aaatgcaact ttgaggaaga gaaattggtt     4680

tccctcctct cccccgtgtt agccccaggt tctgtctgtg ctgtggtgaa gagtgacttg     4740

ggacagtcac caggaaagac gcaaggcaga ggagagagaa tgagggctgc cttctcgagg     4800

aaggtcacag ctcacgaatc tttctaaact taagtgctgc agaagttgaa ctgagattaa     4860

atttagagat gatggtttcc aagacacaca gggccacggt tctttcagtt tttaaacacg     4920

tgcaaagtcc actgaattgc tttctcgtct catctgtcag aagcccctgc attcacaagg     4980

atgggtcttc cagcttgacg atgacctctc ttcggagagc ctcacccatc ttggtaagcc     5040

aagtcagcgg ggcctcatgg agctaaaaat agtttcaggt catgacagat gttatctgta     5100

ttgctgtgtg tgcgatgagt ctggggaagc taacacatgc cttctgaagt ggctagaata     5160

cacactccca cgtcacagcc atgctatgat gaaggggtga gaagcagtgt cccctctgag     5220

gcaaatctct cttcaggcag ccccgcagtc ctcttccgaa atctcattct tttccctctc     5280

ttcctcccca aaaagcccaa actcattgtc agagtgggga gaggggagaa gcagcatcct     5340

gactcctgtc catggtgtga accctgaggg cacgggacag tgagtggagc tctgccacca     5400

cccgtttcca gagcatgggt gaggagggag ggatgccgac ctgttaatat ttgcttcaga     5460

cctttccccg atgaacgaaa tctccaaaag ccttaaacat aaaatggctt agtcaaaaaa     5520

aaaaaaaaaa a                                                          5531


<210>  4
<211>  498
<212>  PRT
<213>  Homo sapiens

<400>  4

Met Leu Gln Cys Arg Pro Ala Gln Glu Phe Ser Phe Gly Pro Arg Ala 
1               5                   10                  15      


Leu Lys Asp Ala Leu Val Ser Thr Asp Ala Ala Leu Gln Gln Leu Tyr 
            20                  25                  30          


Val Ser Ala Phe Ser Pro Ala Glu Arg Leu Phe Leu Ala Glu Ala Tyr 
        35                  40                  45              


Asn Pro Gln Arg Thr Leu Phe Cys Thr Leu Leu Ile Arg Thr Gly Phe 
    50                  55                  60                  


Asp Trp Leu Leu Ser Arg Pro Glu Ala Pro Glu Asp Phe Gln Thr Phe 
65                  70                  75                  80  


His Ala Ser Leu Gln His Arg Lys Pro Arg Leu Ala Arg Lys His Ile 
                85                  90                  95      


Tyr Leu Gln Pro Ile Asp Leu Ser Glu Glu Pro Val Gly Ser Ser Leu 
            100                 105                 110         


Leu His Gln Leu Cys Ser Cys Thr Glu Ala Phe Phe Leu Gly Leu Arg 
        115                 120                 125             


Val Lys Cys Leu Pro Ser Val Ala Ala Ala Ser Ile Arg Cys Ser Ser 
    130                 135                 140                 


Arg Pro Ser Arg Asp Ser Asp Arg Leu Gln Leu His Thr Asp Gly Ile 
145                 150                 155                 160 


Leu Ser Phe Leu Lys Asn Asn Lys Pro Gly Asp Ala Leu Cys Val Leu 
                165                 170                 175     


Gly Leu Thr Leu Ser Asp Leu Tyr Pro His Glu Ala Trp Ser Phe Thr 
            180                 185                 190         


Phe Ser Lys Phe Leu Pro Gly His Glu Val Gly Val Cys Ser Phe Ala 
        195                 200                 205             


Arg Phe Ser Gly Glu Phe Pro Lys Ser Gly Pro Ser Ala Pro Asp Leu 
    210                 215                 220                 


Ala Leu Val Glu Ala Ala Ala Asp Gly Pro Glu Ala Pro Leu Gln Asp 
225                 230                 235                 240 


Arg Gly Trp Ala Leu Cys Phe Ser Ala Leu Gly Met Val Gln Cys Cys 
                245                 250                 255     


Lys Val Thr Cys His Glu Leu Cys His Leu Leu Gly Leu Gly Asn Cys 
            260                 265                 270         


Arg Trp Leu Arg Cys Leu Met Gln Gly Ala Leu Ser Leu Asp Glu Ala 
        275                 280                 285             


Leu Arg Arg Pro Leu Asp Leu Cys Pro Ile Cys Leu Arg Lys Leu Gln 
    290                 295                 300                 


His Val Leu Gly Phe Arg Leu Ile Glu Arg Tyr Gln Arg Leu Tyr Thr 
305                 310                 315                 320 


Trp Thr Gln Ala Val Val Gly Thr Trp Pro Ser Gln Glu Ala Gly Glu 
                325                 330                 335     


Pro Ser Val Trp Glu Asp Thr Pro Pro Ala Ser Ala Asp Ser Gly Met 
            340                 345                 350         


Cys Cys Glu Ser Asp Ser Glu Pro Gly Thr Ser Val Ser Glu Pro Leu 
        355                 360                 365             


Thr Pro Asp Ala Gly Ser His Thr Phe Ala Ser Gly Pro Glu Glu Gly 
    370                 375                 380                 


Leu Ser Tyr Leu Ala Ala Ser Glu Ala Pro Leu Pro Pro Gly Gly Pro 
385                 390                 395                 400 


Ala Glu Ala Ile Lys Glu His Glu Arg Trp Leu Ala Met Cys Ile Gln 
                405                 410                 415     


Ala Leu Gln Arg Glu Val Ala Glu Glu Asp Leu Val Gln Val Asp Arg 
            420                 425                 430         


Ala Val Asp Ala Leu Asp Arg Trp Glu Met Phe Thr Gly Gln Leu Pro 
        435                 440                 445             


Ala Thr Arg Gln Asp Pro Pro Ser Ser Arg Asp Ser Val Gly Leu Arg 
    450                 455                 460                 


Lys Val Leu Gly Asp Lys Phe Ser Ser Leu Arg Arg Lys Leu Ser Ala 
465                 470                 475                 480 


Arg Lys Leu Ala Arg Ala Glu Ser Ala Pro Arg Pro Trp Asp Gly Glu 
                485                 490                 495     


Glu Ser 
        


<210>  5
<211>  1290
<212>  DNA
<213>  Homo sapiens

<400>  5
ggctgagcct ataaagcggc aggtgcgcgc cgccctacag acgttcgcac acctgggtgc       60

cagcgcccca gaggtcccgg gacagcccga ggcgccgcgc ccgccgcccc gagctcccca      120

agccttcgag agcggcgcac actcccggtc tccactcgct cttccaacac ccgctcgttt      180

tggcggcagc tcgtgtccca gagaccgagt tgccccagag accgagacgc cgccgctgcg      240

aaggaccaat gagagccccg ctgctaccgc cggcgccggt ggtgctgtcg ctcttgatac      300

tcggctcagg ccattatgct gctggattgg acctcaatga cacctactct gggaagcgtg      360

aaccattttc tggggaccac agtgctgatg gatttgaggt tacctcaaga agtgagatgt      420

cttcagggag tgagatttcc cctgtgagtg aaatgccttc tagtagtgaa ccgtcctcgg      480

gagccgacta tgactactca gaagagtatg ataacgaacc acaaatacct ggctatattg      540

tcgatgattc agtcagagtt gaacaggtag ttaagccccc ccaaaacaag acggaaagtg      600

aaaatacttc agataaaccc aaaagaaaga aaaagggagg caaaaatgga aaaaatagaa      660

gaaacagaaa gaagaaaaat ccatgtaatg cagaatttca aaatttctgc attcacggag      720

aatgcaaata tatagagcac ctggaagcag taacatgcaa atgtcagcaa gaatatttcg      780

gtgaacggtg tggggaaaag tccatgaaaa ctcacagcat gattgacagt agtttatcaa      840

aaattgcatt agcagccata gctgccttta tgtctgctgt gatcctcaca gctgttgctg      900

ttattacagt ccagcttaga agacaatacg tcaggaaata tgaaggagaa gctgaggaac      960

gaaagaaact tcgacaagag aatggaaatg tacatgctat agcataactg aagataaaat     1020

tacaggatat cacattggag tcactgccaa gtcatagcca taaatgatga gtcggtcctc     1080

tttccagtgg atcataagac aatggaccct ttttgttatg atggttttaa actttcaatt     1140

gtcacttttt atgctatttc tgtatataaa ggtgcacgaa ggtaaaaagt attttttcaa     1200

gttgtaaata atttatttaa tatttaatgg aagtgtattt attttacagc tcattaaact     1260

tttttaacca aacagaaaaa aaaaaaaaaa                                      1290


<210>  6
<211>  252
<212>  PRT
<213>  Homo sapiens

<400>  6

Met Arg Ala Pro Leu Leu Pro Pro Ala Pro Val Val Leu Ser Leu Leu 
1               5                   10                  15      


Ile Leu Gly Ser Gly His Tyr Ala Ala Gly Leu Asp Leu Asn Asp Thr 
            20                  25                  30          


Tyr Ser Gly Lys Arg Glu Pro Phe Ser Gly Asp His Ser Ala Asp Gly 
        35                  40                  45              


Phe Glu Val Thr Ser Arg Ser Glu Met Ser Ser Gly Ser Glu Ile Ser 
    50                  55                  60                  


Pro Val Ser Glu Met Pro Ser Ser Ser Glu Pro Ser Ser Gly Ala Asp 
65                  70                  75                  80  


Tyr Asp Tyr Ser Glu Glu Tyr Asp Asn Glu Pro Gln Ile Pro Gly Tyr 
                85                  90                  95      


Ile Val Asp Asp Ser Val Arg Val Glu Gln Val Val Lys Pro Pro Gln 
            100                 105                 110         


Asn Lys Thr Glu Ser Glu Asn Thr Ser Asp Lys Pro Lys Arg Lys Lys 
        115                 120                 125             


Lys Gly Gly Lys Asn Gly Lys Asn Arg Arg Asn Arg Lys Lys Lys Asn 
    130                 135                 140                 


Pro Cys Asn Ala Glu Phe Gln Asn Phe Cys Ile His Gly Glu Cys Lys 
145                 150                 155                 160 


Tyr Ile Glu His Leu Glu Ala Val Thr Cys Lys Cys Gln Gln Glu Tyr 
                165                 170                 175     


Phe Gly Glu Arg Cys Gly Glu Lys Ser Met Lys Thr His Ser Met Ile 
            180                 185                 190         


Asp Ser Ser Leu Ser Lys Ile Ala Leu Ala Ala Ile Ala Ala Phe Met 
        195                 200                 205             


Ser Ala Val Ile Leu Thr Ala Val Ala Val Ile Thr Val Gln Leu Arg 
    210                 215                 220                 


Arg Gln Tyr Val Arg Lys Tyr Glu Gly Glu Ala Glu Glu Arg Lys Lys 
225                 230                 235                 240 


Leu Arg Gln Glu Asn Gly Asn Val His Ala Ile Ala 
                245                 250         


<210>  7
<211>  1434
<212>  DNA
<213>  Homo sapiens

<400>  7
tataaagatt cactgggact ggtgaggtgg cagtgctcag cagcatccga caggagccct       60

ggcaaacagg acggatttcc aggactctac cagctgccag acacggcagg gagagacccc      120

agacctcctg ggtcctggct gtgggcccgg attgggctcc caagtggcgt ttgactcacg      180

tggggacact cttggaagag acgacaccag gagcctgaat ggggaacgat tctgtcagct      240

acgagtatgg ggattacagc gacctctcgg accgccctgt ggactgcctg gatggcgcct      300

gcctggccat cgacccgctg cgcgtggccc cgctcccact gtatgccgcc atcttcctgg      360

tgggggtgcc gggcaatgcc atggtggcct gggtggctgg gaaggtggcc cgccggaggg      420

tgggtgccac ctggttgctc cacctggccg tggcggattt gctgtgctgt ttgtctctgc      480

ccatcctggc agtgcccatt gcccgtggag gccactggcc gtatggtgca gtgggctgtc      540

gggcgctgcc ctccatcatc ctgctgacca tgtatgccag cgtcctgctc ctggcagctc      600

tcagtgccga cctctgcttc ctggctctcg ggcctgcctg gtggtctacg gttcagcggg      660

cgtgcggggt gcaggtggcc tgtggggcag cctggacact ggccttgctg ctcaccgtgc      720

cctccgccat ctaccgccgg ctgcaccagg agcacttccc agcccggctg cagtgtgtgg      780

tggactacgg cggctcctcc agcaccgaga atgcggtgac tgccatccgg tttctttttg      840

gcttcctggg gcccctggtg gccgtggcca gctgccacag tgccctcctg tgctgggcag      900

cccgacgctg ccggccgctg ggcacagcca ttgtggtggg gttttttgtc tgctgggcac      960

cctaccacct gctggggctg gtgctcactg tggcggcccc gaactccgca ctcctggcca     1020

gggccctgcg ggctgaaccc ctcatcgtgg gccttgccct cgctcacagc tgcctcaatc     1080

ccatgctctt cctgtatttt gggagggctc aactccgccg gtcactgcca gctgcctgtc     1140

actgggccct gagggagtcc cagggccagg acgaaagtgt ggacagcaag aaatccacca     1200

gccatgacct ggtctcggag atggaggtgt aggctggaga gacattgtgg gtgtgtatct     1260

tcttatctca tttcacaaga ctggcttcag gcatagctgg atccaggagc tcaatgatgt     1320

cttcatttta ttccttcctt cattcaacag atatccatca tgcacttgct atgtgcaagg     1380

cctttttagg cactagagat atagcagtga ccaaaacaga cacaaatcct gccc           1434


<210>  8
<211>  337
<212>  PRT
<213>  Homo sapiens

<400>  8

Met Gly Asn Asp Ser Val Ser Tyr Glu Tyr Gly Asp Tyr Ser Asp Leu 
1               5                   10                  15      


Ser Asp Arg Pro Val Asp Cys Leu Asp Gly Ala Cys Leu Ala Ile Asp 
            20                  25                  30          


Pro Leu Arg Val Ala Pro Leu Pro Leu Tyr Ala Ala Ile Phe Leu Val 
        35                  40                  45              


Gly Val Pro Gly Asn Ala Met Val Ala Trp Val Ala Gly Lys Val Ala 
    50                  55                  60                  


Arg Arg Arg Val Gly Ala Thr Trp Leu Leu His Leu Ala Val Ala Asp 
65                  70                  75                  80  


Leu Leu Cys Cys Leu Ser Leu Pro Ile Leu Ala Val Pro Ile Ala Arg 
                85                  90                  95      


Gly Gly His Trp Pro Tyr Gly Ala Val Gly Cys Arg Ala Leu Pro Ser 
            100                 105                 110         


Ile Ile Leu Leu Thr Met Tyr Ala Ser Val Leu Leu Leu Ala Ala Leu 
        115                 120                 125             


Ser Ala Asp Leu Cys Phe Leu Ala Leu Gly Pro Ala Trp Trp Ser Thr 
    130                 135                 140                 


Val Gln Arg Ala Cys Gly Val Gln Val Ala Cys Gly Ala Ala Trp Thr 
145                 150                 155                 160 


Leu Ala Leu Leu Leu Thr Val Pro Ser Ala Ile Tyr Arg Arg Leu His 
                165                 170                 175     


Gln Glu His Phe Pro Ala Arg Leu Gln Cys Val Val Asp Tyr Gly Gly 
            180                 185                 190         


Ser Ser Ser Thr Glu Asn Ala Val Thr Ala Ile Arg Phe Leu Phe Gly 
        195                 200                 205             


Phe Leu Gly Pro Leu Val Ala Val Ala Ser Cys His Ser Ala Leu Leu 
    210                 215                 220                 


Cys Trp Ala Ala Arg Arg Cys Arg Pro Leu Gly Thr Ala Ile Val Val 
225                 230                 235                 240 


Gly Phe Phe Val Cys Trp Ala Pro Tyr His Leu Leu Gly Leu Val Leu 
                245                 250                 255     


Thr Val Ala Ala Pro Asn Ser Ala Leu Leu Ala Arg Ala Leu Arg Ala 
            260                 265                 270         


Glu Pro Leu Ile Val Gly Leu Ala Leu Ala His Ser Cys Leu Asn Pro 
        275                 280                 285             


Met Leu Phe Leu Tyr Phe Gly Arg Ala Gln Leu Arg Arg Ser Leu Pro 
    290                 295                 300                 


Ala Ala Cys His Trp Ala Leu Arg Glu Ser Gln Gly Gln Asp Glu Ser 
305                 310                 315                 320 


Val Asp Ser Lys Lys Ser Thr Ser His Asp Leu Val Ser Glu Met Glu 
                325                 330                 335     


Val 
    


<210>  9
<211>  10540
<212>  DNA
<213>  Homo sapiens

<400>  9
aggagccgga ggaggagccg ccgccgccgt tgacccggcc gccggccggg agctgggaga       60

gatgcggagc ccggccaccg gcgtccccct cccaacgccg ccgccgccgc tgctgctgct      120

gttgctgctg ctgctgccgc cgccactatt gggagaccaa gtggggccct gtcgttcctt      180

ggggtccagg ggacgaggct cttcgggggc ctgcgccccc atgggctggc tctgtccatc      240

ctcagcgtcg aacctctggc tctacaccag ccgctgcagg gatgcgggca ctgagctgac      300

tggccacctg gtaccccacc acgatggcct gagggtttgg tgtccagaat ccgaggccca      360

tattccccta ccaccagctc ctgaaggctg cccctggagc tgtcgcctcc tgggcattgg      420

aggccacctt tccccacagg gcaagctcac actgcccgag gagcacccgt gcttaaaggc      480

tccacggctc agatgccagt cctgcaagct ggcacaggcc cccgggctca gggcagggga      540

aaggtcacca gaagagtccc tgggtgggcg tcggaaaagg aatgtaaata cagcccccca      600

gttccagccc cccagctacc aggccacagt gccggagaac cagccagcag gcacccctgt      660

tgcatccctg agggccatcg acccggacga gggtgaggca ggtcgactgg agtacaccat      720

ggatgccctc tttgatagcc gctccaacca gttcttctcc ctggacccag tcactggtgc      780

agtaaccaca gccgaggagc tggatcgtga gaccaagagc acccacgtct tcagggtcac      840

ggcgcaggac cacggcatgc cccgacgaag tgccctggct acactcacca tcttggttac      900

tgacaccaat gaccatgacc ctgtgttcga gcagcaggag tacaaggaga gcctcaggga      960

gaacctggag gttggctatg aggtgctcac tgtcagggcc acggatggtg atgcccctcc     1020

caatgccaat attctgtacc gcctgctgga ggggtctggg ggcagcccct ctgaagtctt     1080

tgagatcgac cctcgctctg gggtgatccg aacccgtggc cctgtggatc gggaagaggt     1140

ggaatcctac cagctgacgg tagaggcaag tgaccagggt cgggacccgg gtcctcggag     1200

taccacagcc gctgttttcc tttctgtgga ggatgacaat gataatgccc cccagtttag     1260

tgagaagcgc tatgtggtcc aggtgaggga ggatgtgact ccaggggccc cagtactccg     1320

agtcacagcc tcggatcgag acaaggggag caatgccgtg gtgcactata gcatcatgag     1380

tggcaatgct cggggacagt tttatctgga tgcccagact ggagctctgg atgtggtgag     1440

ccctcttgac tatgagacga ccaaggagta caccctacgg gtgcgagcac aggatggtgg     1500

ccgtccccca ctctctaatg tctctggctt ggtgacagta caggtcctgg atatcaacga     1560

caatgccccc atcttcgtca gcaccccttt ccaggctact gtcctggaga gtgtcccctt     1620

aggctacctg gttctccatg tccaggctat cgacgctgat gctggtgaca atgcccgcct     1680

ggaataccgc cttgctgggg tgggacatga cttccccttc accatcaaca atggcacagg     1740

ctggatctct gtggctgctg aactggaccg ggaggaagtt gatttctaca gctttggggt     1800

agaagctcga gaccatggca ctccagcact cactgcctcg gccagtgtca gcgtgactgt     1860

cctggatgtc aacgacaaca atccaacctt tacccaacca gagtacacag tgcggctcaa     1920

tgaggatgca gctgtgggca ccagcgtggt gacggtgtca gctgtggacc gtgatgctca     1980

tagtgtcatc acctaccaga tcaccagtgg caatactcga aaccgcttct ccatcaccag     2040

ccaaagtggt ggtgggctgg tatcccttgc cctgccactg gactacaaac ttgagcggca     2100

gtatgtgttg gctgttaccg cctccgatgg cactcggcag gacacggcac agattgtggt     2160

gaatgtcacc gacgccaaca cccatcgtcc tgtctttcag agctcccact atacagtgaa     2220

tgttaatgag gaccggccgg caggcaccac ggtggtgctg atcagcgcca cggatgagga     2280

cacaggtgag aatgcccgca tcacctactt catggaggac agcatccccc agttccgcat     2340

cgatgcagac acgggggctg tcaccaccca ggctgagctg gactatgaag accaagtgtc     2400

ttacaccctg gccattactg ctcgggacaa tggcattccc cagaagtccg acaccaccta     2460

cctggagatc ctggtgaacg acgtgaatga caatgcccct cagttcctgc gagactccta     2520

ccagggcagt gtctatgagg atgtgccacc cttcactagc gtcctgcaga tctcagccac     2580

tgatcgtgat tctggactta atggcagggt cttctacacc ttccaaggag gcgacgatgg     2640

agacggtgac tttattgttg agtccacgtc aggcatcgtg cgaacgctac ggaggctgga     2700

tcgagagaac gtggcccagt atgtcttgcg ggcatatgca gtggacaagg ggatgccccc     2760

agcccgcaca cctatggaag tgacagtcac tgtgttggat gtgaatgaca atccccctgt     2820

ctttgagcag gatgagtttg atgtgtttgt ggaagagaac agccccattg ggctagccgt     2880

ggcccgggtc acagccactg accccgatga aggcaccaat gcccagatta tgtaccagat     2940

tgtggagggc aacatccctg aggtctttca gctggacatc ttctccgggg agctgacagc     3000

cctggtagac ttagactacg aggaccggcc tgagtacgtc ctggtcatcc aggccacgtc     3060

agctcctctg gtgagccggg ctacagtcca cgtccgcctc cttgaccgca atgacaaccc     3120

accagtgctg ggcaactttg agatcctttt caacaactat gtcaccaatc gctcaagcag     3180

cttccctggg ggtgccattg gccgagtacc tgcccatgac cctgatatct cagatagtct     3240

gacttacagc tttgagcggg gaaatgaact cagcctggtc ctgctcaatg cctccacggg     3300

tgagctgaag ctaagccgcg cactggacaa caaccggcct ctggaggcca tcatgagcgt     3360

gctggtgtca gacggcgtac acagcgtgac cgcccagtgc gcgctgcgtg tgaccatcat     3420

caccgatgag atgctcaccc acagcatcac gctgcgcctg gaggacatgt cacccgagcg     3480

cttcctgtca ccactgctag gcctcttcat ccaggcggtg gccgccacgc tggccacgcc     3540

accggaccac gtggtggtct tcaacgtaca gcgggacacc gacgcccccg ggggccacat     3600

cctcaacgtg agcctgtcgg tgggccagcc gccagggccc gggggcgggc cgcccttcct     3660

gccctctgag gacctgcagg agcgcctata cctcaaccgc agcctgctga cggccatctc     3720

ggcacagcgc gtgctgccct tcgacgacaa catctgcctg cgggagccct gcgagaacta     3780

catgcgctgc gtgtcggtgc tgcgcttcga ctcctccgcg cccttcatcg cctcctcctc     3840

cgtgctcttc cggcccatcc accccgtcgg agggctgcgc tgccgctgcc cgcccggctt     3900

cacgggtgac tactgcgaga ccgaggtgga cctctgctac tcgcggccct gtggccccca     3960

cgggcgctgc cgcagccgcg agggcggcta cacctgcctc tgtcgtgatg gctacacggg     4020

tgagcactgt gaggtgagtg ctcgctcagg ccgttgcacc ccgggtgtct gcaagaatgg     4080

gggcacctgt gtcaacctgc tggtgggcgg tttcaagtgc gattgcccat ctggagactt     4140

cgagaagccc tactgccagg tgaccacgcg cagcttcccc gcccactcct tcatcacctt     4200

tcgcggcctg cgccagcgtt tccacttcac cctggccctc tcgtttgcca caaaggagcg     4260

cgacgggttg ctgttgtaca atgggcgttt caatgagaag catgactttg tggccctcga     4320

ggtgatccag gagcaggtcc agctcacctt ctctgcaggg gagtcaacca ccacggtgtc     4380

cccattcgtg cccggaggag tcagtgatgg ccagtggcat acggtgcagc tgaaatacta     4440

caataagcca ctgttgggtc agacagggct cccacagggc ccatcagagc agaaggtggc     4500

tgtggtgacc gtggatggct gtgacacagg agtggccttg cgcttcggat ctgtcctggg     4560

caactactcc tgtgctgccc agggcaccca gggtggcagc aagaagtctc tggatctgac     4620

ggggcccctg ctactaggcg gggtgcctga cctgcccgag agcttcccag tccgaatgcg     4680

gcagttcgtg ggctgcatgc ggaacctgca ggtggacagc cggcacatag acatggctga     4740

cttcattgcc aacaatggca ccgtgcctgg ctgccctgcc aagaagaacg tgtgtgacag     4800

caacacttgc cacaatgggg gcacttgcgt gaaccagtgg gacgcgttca gctgcgagtg     4860

ccccctgggc tttgggggca agagctgcgc ccaggaaatg gccaatccac agcacttcct     4920

gggcagcagc ctggtggcct ggcatggcct ctcgctgccc atctcccaac cctggtacct     4980

cagcctcatg ttccgcacgc gccaggccga cggtgtcctg ctgcaggcca tcaccagggg     5040

gcgcagcacc atcaccctac agctacgaga gggccacgtg atgctgagcg tggagggcac     5100

agggcttcag gcctcctctc tccgtctgga gccaggccgg gccaatgacg gtgactggca     5160

ccatgcacag ctggcactgg gagccagcgg ggggcccggc catgccattc tgtccttcga     5220

ttatgggcag cagagagcag agggcaacct gggcccccgg ctgcatggtc tgcacctgag     5280

caacataaca gtgggcggaa tacctgggcc agccggcggt gtggcccgtg gctttcgggg     5340

ctgtttgcag ggtgtgcggg tgagcgatac gccggagggg gttaacagcc tggatcccag     5400

ccatggggag agcatcaacg tggagcaagg ctgtagcctg cctgaccctt gtgactcaaa     5460

cccgtgtcct gctaacagct attgcagcaa cgactgggac agctattcct gcagctgtga     5520

tccaggttac tatggtgaca actgtactaa tgtgtgtgac ctgaacccgt gtgagcacca     5580

gtctgtgtgt acccgcaagc ccagtgcccc ccatggctat acctgcgagt gtcccccaaa     5640

ttaccttggg ccatactgtg agaccaggat tgaccagcct tgtccccgtg gctggtgggg     5700

acatcccaca tgtggcccat gcaactgtga tgtcagcaaa ggctttgacc cagactgcaa     5760

caagacaagc ggcgagtgcc actgcaagga gaaccactac cggcccccag gcagccccac     5820

ctgcctcttg tgtgactgct accccacagg ctccttgtcc agagtctgtg accctgagga     5880

tggccagtgt ccatgcaagc caggtgtcat cgggcgtcag tgtgaccgct gtgacaaccc     5940

ttttgctgag gtcaccacca atggctgtga agtgaattat gacagctgcc cacgagcgat     6000

tgaggctggg atctggtggc cccgtacccg cttcgggctg cctgctgctg ctccctgtcc     6060

caaaggctcc tttgggactg ctgtgcgcca ctgtgatgag cacagggggt ggctcccccc     6120

aaacctcttc aactgcacgt ccatcacctt ctcagaactg aagggcttcg ctgagcggct     6180

acagcggaat gagtcaggcc tagactcagg gcgctcccag cagctagccc tgctcctgcg     6240

caacgccacg cagcacacag ctggctactt cggcagcgac gtcaaggtgg cctaccagct     6300

ggccacgcgg ctgctggccc acgagagcac ccagcggggc tttgggctgt ctgccacaca     6360

ggacgtgcac ttcactgaga atctgctgcg ggtgggcagc gccctcctgg acacagccaa     6420

caagcggcac tgggagctga tccagcagac agagggtggc accgcctggc tgctccagca     6480

ctatgaggcc tacgccagtg ccctggccca gaacatgcgg cacacctacc taagcccctt     6540

caccatcgtc acgcccaaca ttgtcatctc cgtagtgcgc ttggacaaag ggaactttgc     6600

tggggccaag ctgccccgct acgaggccct gcgtggggag cagcccccgg accttgagac     6660

aacagtcatt ctgcctgagt ctgtcttcag agagacgccc cccgtggtca ggcccgcagg     6720

ccccggagag gcccaggagc cagaggagct ggcacggcga cagcgacggc acccggagct     6780

gagccagggt gaggctgtgg ccagcgtcat catctaccgc accctggccg ggctactgcc     6840

tcataactat gaccctgaca agcgcagctt gagagtcccc aaacgcccga tcatcaacac     6900

acccgtggtg agcatcagcg tccatgatga tgaggagctt ctgccccggg ccctggacaa     6960

acccgtcacg gtgcagttcc gcctgctgga gacagaggag cggaccaagc ccatctgtgt     7020

cttctggaac cattcaatcc tggtcagtgg cacaggtggc tggtcggcca gaggctgtga     7080

agtcgtcttc cgcaatgaga gccacgtcag ctgccagtgc aaccacatga cgagcttcgc     7140

tgtgctcatg gacgtttctc ggcgggagaa tggggagatc ctgccactga agacactgac     7200

atacgtggct ctaggtgtca ccttggctgc ccttctgctc accttcttct tcctcactct     7260

cttgcgtatc ctgcgctcca accaacacgg catccgacgt aacctgacag ctgccctggg     7320

cctggctcag ctggtcttcc tcctgggaat caaccaggct gacctccctt ttgcctgcac     7380

agtcattgcc atcctgctgc acttcctgta cctctgcacc ttttcctggg ctctgctgga     7440

ggccttgcac ctgtaccggg cactcactga ggtgcgcgat gtcaacaccg gccccatgcg     7500

cttctactac atgctgggct ggggcgtgcc tgccttcatc acagggctag ccgtgggcct     7560

ggaccccgag ggctacggga accctgactt ctgctggctc tccatctatg acacgctcat     7620

ctggagtttt gctggcccgg tggcctttgc cgtctcgatg agtgtcttcc tgtacatcct     7680

ggcggcccgg gcctcctgtg ctgcccagcg gcagggcttt gagaagaaag gtcctgtctc     7740

gggcctgcag ccctccttcg ccgtcctcct gctgctgagc gccacgtggc tgctggcact     7800

gctctctgtc aacagcgaca ccctcctctt ccactacctc tttgctacct gcaattgcat     7860

ccagggcccc ttcatcttcc tctcctatgt ggtgcttagc aaggaggtcc ggaaagcact     7920

caagcttgcc tgcagccgca agcccagccc tgaccctgct ctgaccacca agtccaccct     7980

gacctcgtcc tacaactgcc ccagccccta cgcagatggg cggctgtacc agccctacgg     8040

agactcggcc ggctctctgc acagcaccag tcgctcgggc aagagtcagc ccagctacat     8100

ccccttcttg ctgagggagg agtccgcact gaaccctggc caagggcccc ctggcctggg     8160

ggatccaggc agcctgttcc tggaaggtca agaccagcag catgatcctg acacggactc     8220

cgacagtgac ctgtccttag aagacgacca gagtggctcc tatgcctcta cccactcatc     8280

agacagtgag gaggaagaag aggaggagga agaggaggcc gccttccctg gagagcaggg     8340

ctgggatagc ctgctggggc ctggagcaga gagactgccc ctgcacagta ctcccaagga     8400

tgggggccca gggcctggca aggccccctg gccaggagac tttgggacca cagcaaaaga     8460

gagtagtggc aacggggccc ctgaggagcg gctgcgggag aatggagatg ccctgtctcg     8520

agaggggtcc ctaggccccc ttccaggctc ttctgcccag cctcacaaag gcatccttaa     8580

gaagaagtgt ctgcccacca tcagcgagaa gagcagcctc ctgcggctcc ccctggagca     8640

atgcacaggg tcttcccggg gctcctccgc tagtgagggc agccggggag gcccccctcc     8700

ccgcccaccg ccccggcaga gcctccagga gcagctgaac ggggtcatgc ccatcgccat     8760

gagcatcaag gcaggcacgg tggatgagga ctcgtcaggc tccgaatttc tcttctttaa     8820

cttcctgcat taaccctggg ccgtggttcc tacgcccgag gctcccttcc cttccccagc     8880

cgcactcatg ccctgctcct gtcttgtgct ttatcctgcc ccgctcccca tcgcctgccc     8940

gcagcagcga cgaaacgtcc atctgaggag cctgggcctt gccgggaggg gtactcaccc     9000

cacctaaggc catctagtgc caactccccc cccaccattc ccctcactgc actttggacc     9060

cctggggcca acatctccaa gacaaagttt ttcagaaaag aggaaaaaaa gaatttaaaa     9120

aaggatctcc actcttcatg acttcaggga ttcatttttt ttatacgctg gaaattgact     9180

cccctttccc ttcccaaaga ggataggacc tcccaggatg cttcccagcc tctcctcagt     9240

ttcccatctg ctgtgcctct gggaggagag ggactcctgg ggggcctgcc cctcatacgc     9300

catcaccaaa aggaaaggac aaagccacac gcagccaggg cttcacaccc ttcaggctgc     9360

acccgggcag gcctcagaac ggtgaggggc cagggcaaag ggtgtgcctc gtcctgcccg     9420

cactgcctct cccaggaact ggaaaagccc tgtccggtga gggggcagaa ggactcagcg     9480

cccctggacc cccaaatgct gcatgaacac attttcaggg gagcctgtgc ccccaggcgg     9540

gggtcgggca gccccagccc ctctcctttt cctggactct ggccgtgcgc ggcagcccag     9600

gtgtttgctc agttgctgac ccaaaagtgc ttcatttttc gtgcccgccc cgcgccccgg     9660

gcaggccagt catgtgttaa gttgcgcttc tttgctgtga tgtgggtggg ggaggaagag     9720

taaacacagt gctggctcgg ctgccctgag ggtgctcaat caagcacagg tttcaagtct     9780

gggttctggt gtccactcac ccaccccacc ccccaaaatc agacaaatgc tactttgtct     9840

aacctgctgt ggcctctgag acatgttcta tttttaaccc cttcttggaa ttggctctct     9900

tcttcaaagg accaggtcct gttcctcttt ctccccgact ccaccccagc tccctgtgaa     9960

gagagagtta atatatttgt tttatttatt tgctttttgt gttgggatgg gttcgtgtcc    10020

agtcccgggg gtctgatatg gccatcacag gctgggtgtt cccagcagcc ctggcttggg    10080

ggcttgacgc ccttcccctt gccccaggcc atcatctccc cacctctcct cccctctcct    10140

cagttttgcc gactgctttt catctgagtc accatttact ccaagcatgt attccagact    10200

tgtcactgac tttccttctg gagcaggtgg ctagaaaaag aggctgtggg caggaaagaa    10260

aggctcctgt ttctcatttg tgaggccagc ctctggcttt tctgccgtgg attctccccc    10320

gtcttctccc ctcagcaatt cctgcaaagg gttaaaaatt taactggttt ttactactga    10380

tgacttgatt taaaaaaaat acaaagatgc tggatgctaa cttggtacta accatcagat    10440

tgtacagttt ggttgttgct gtaaataggg tagcgttttg ttgttgttgt tttttcatgc    10500

cccatactac tgaataaact agttctgtgc gggtacagca                          10540


<210>  10
<211>  2923
<212>  PRT
<213>  Homo sapiens

<400>  10

Met Arg Ser Pro Ala Thr Gly Val Pro Leu Pro Thr Pro Pro Pro Pro 
1               5                   10                  15      


Leu Leu Leu Leu Leu Leu Leu Leu Leu Pro Pro Pro Leu Leu Gly Asp 
            20                  25                  30          


Gln Val Gly Pro Cys Arg Ser Leu Gly Ser Arg Gly Arg Gly Ser Ser 
        35                  40                  45              


Gly Ala Cys Ala Pro Met Gly Trp Leu Cys Pro Ser Ser Ala Ser Asn 
    50                  55                  60                  


Leu Trp Leu Tyr Thr Ser Arg Cys Arg Asp Ala Gly Thr Glu Leu Thr 
65                  70                  75                  80  


Gly His Leu Val Pro His His Asp Gly Leu Arg Val Trp Cys Pro Glu 
                85                  90                  95      


Ser Glu Ala His Ile Pro Leu Pro Pro Ala Pro Glu Gly Cys Pro Trp 
            100                 105                 110         


Ser Cys Arg Leu Leu Gly Ile Gly Gly His Leu Ser Pro Gln Gly Lys 
        115                 120                 125             


Leu Thr Leu Pro Glu Glu His Pro Cys Leu Lys Ala Pro Arg Leu Arg 
    130                 135                 140                 


Cys Gln Ser Cys Lys Leu Ala Gln Ala Pro Gly Leu Arg Ala Gly Glu 
145                 150                 155                 160 


Arg Ser Pro Glu Glu Ser Leu Gly Gly Arg Arg Lys Arg Asn Val Asn 
                165                 170                 175     


Thr Ala Pro Gln Phe Gln Pro Pro Ser Tyr Gln Ala Thr Val Pro Glu 
            180                 185                 190         


Asn Gln Pro Ala Gly Thr Pro Val Ala Ser Leu Arg Ala Ile Asp Pro 
        195                 200                 205             


Asp Glu Gly Glu Ala Gly Arg Leu Glu Tyr Thr Met Asp Ala Leu Phe 
    210                 215                 220                 


Asp Ser Arg Ser Asn Gln Phe Phe Ser Leu Asp Pro Val Thr Gly Ala 
225                 230                 235                 240 


Val Thr Thr Ala Glu Glu Leu Asp Arg Glu Thr Lys Ser Thr His Val 
                245                 250                 255     


Phe Arg Val Thr Ala Gln Asp His Gly Met Pro Arg Arg Ser Ala Leu 
            260                 265                 270         


Ala Thr Leu Thr Ile Leu Val Thr Asp Thr Asn Asp His Asp Pro Val 
        275                 280                 285             


Phe Glu Gln Gln Glu Tyr Lys Glu Ser Leu Arg Glu Asn Leu Glu Val 
    290                 295                 300                 


Gly Tyr Glu Val Leu Thr Val Arg Ala Thr Asp Gly Asp Ala Pro Pro 
305                 310                 315                 320 


Asn Ala Asn Ile Leu Tyr Arg Leu Leu Glu Gly Ser Gly Gly Ser Pro 
                325                 330                 335     


Ser Glu Val Phe Glu Ile Asp Pro Arg Ser Gly Val Ile Arg Thr Arg 
            340                 345                 350         


Gly Pro Val Asp Arg Glu Glu Val Glu Ser Tyr Gln Leu Thr Val Glu 
        355                 360                 365             


Ala Ser Asp Gln Gly Arg Asp Pro Gly Pro Arg Ser Thr Thr Ala Ala 
    370                 375                 380                 


Val Phe Leu Ser Val Glu Asp Asp Asn Asp Asn Ala Pro Gln Phe Ser 
385                 390                 395                 400 


Glu Lys Arg Tyr Val Val Gln Val Arg Glu Asp Val Thr Pro Gly Ala 
                405                 410                 415     


Pro Val Leu Arg Val Thr Ala Ser Asp Arg Asp Lys Gly Ser Asn Ala 
            420                 425                 430         


Val Val His Tyr Ser Ile Met Ser Gly Asn Ala Arg Gly Gln Phe Tyr 
        435                 440                 445             


Leu Asp Ala Gln Thr Gly Ala Leu Asp Val Val Ser Pro Leu Asp Tyr 
    450                 455                 460                 


Glu Thr Thr Lys Glu Tyr Thr Leu Arg Val Arg Ala Gln Asp Gly Gly 
465                 470                 475                 480 


Arg Pro Pro Leu Ser Asn Val Ser Gly Leu Val Thr Val Gln Val Leu 
                485                 490                 495     


Asp Ile Asn Asp Asn Ala Pro Ile Phe Val Ser Thr Pro Phe Gln Ala 
            500                 505                 510         


Thr Val Leu Glu Ser Val Pro Leu Gly Tyr Leu Val Leu His Val Gln 
        515                 520                 525             


Ala Ile Asp Ala Asp Ala Gly Asp Asn Ala Arg Leu Glu Tyr Arg Leu 
    530                 535                 540                 


Ala Gly Val Gly His Asp Phe Pro Phe Thr Ile Asn Asn Gly Thr Gly 
545                 550                 555                 560 


Trp Ile Ser Val Ala Ala Glu Leu Asp Arg Glu Glu Val Asp Phe Tyr 
                565                 570                 575     


Ser Phe Gly Val Glu Ala Arg Asp His Gly Thr Pro Ala Leu Thr Ala 
            580                 585                 590         


Ser Ala Ser Val Ser Val Thr Val Leu Asp Val Asn Asp Asn Asn Pro 
        595                 600                 605             


Thr Phe Thr Gln Pro Glu Tyr Thr Val Arg Leu Asn Glu Asp Ala Ala 
    610                 615                 620                 


Val Gly Thr Ser Val Val Thr Val Ser Ala Val Asp Arg Asp Ala His 
625                 630                 635                 640 


Ser Val Ile Thr Tyr Gln Ile Thr Ser Gly Asn Thr Arg Asn Arg Phe 
                645                 650                 655     


Ser Ile Thr Ser Gln Ser Gly Gly Gly Leu Val Ser Leu Ala Leu Pro 
            660                 665                 670         


Leu Asp Tyr Lys Leu Glu Arg Gln Tyr Val Leu Ala Val Thr Ala Ser 
        675                 680                 685             


Asp Gly Thr Arg Gln Asp Thr Ala Gln Ile Val Val Asn Val Thr Asp 
    690                 695                 700                 


Ala Asn Thr His Arg Pro Val Phe Gln Ser Ser His Tyr Thr Val Asn 
705                 710                 715                 720 


Val Asn Glu Asp Arg Pro Ala Gly Thr Thr Val Val Leu Ile Ser Ala 
                725                 730                 735     


Thr Asp Glu Asp Thr Gly Glu Asn Ala Arg Ile Thr Tyr Phe Met Glu 
            740                 745                 750         


Asp Ser Ile Pro Gln Phe Arg Ile Asp Ala Asp Thr Gly Ala Val Thr 
        755                 760                 765             


Thr Gln Ala Glu Leu Asp Tyr Glu Asp Gln Val Ser Tyr Thr Leu Ala 
    770                 775                 780                 


Ile Thr Ala Arg Asp Asn Gly Ile Pro Gln Lys Ser Asp Thr Thr Tyr 
785                 790                 795                 800 


Leu Glu Ile Leu Val Asn Asp Val Asn Asp Asn Ala Pro Gln Phe Leu 
                805                 810                 815     


Arg Asp Ser Tyr Gln Gly Ser Val Tyr Glu Asp Val Pro Pro Phe Thr 
            820                 825                 830         


Ser Val Leu Gln Ile Ser Ala Thr Asp Arg Asp Ser Gly Leu Asn Gly 
        835                 840                 845             


Arg Val Phe Tyr Thr Phe Gln Gly Gly Asp Asp Gly Asp Gly Asp Phe 
    850                 855                 860                 


Ile Val Glu Ser Thr Ser Gly Ile Val Arg Thr Leu Arg Arg Leu Asp 
865                 870                 875                 880 


Arg Glu Asn Val Ala Gln Tyr Val Leu Arg Ala Tyr Ala Val Asp Lys 
                885                 890                 895     


Gly Met Pro Pro Ala Arg Thr Pro Met Glu Val Thr Val Thr Val Leu 
            900                 905                 910         


Asp Val Asn Asp Asn Pro Pro Val Phe Glu Gln Asp Glu Phe Asp Val 
        915                 920                 925             


Phe Val Glu Glu Asn Ser Pro Ile Gly Leu Ala Val Ala Arg Val Thr 
    930                 935                 940                 


Ala Thr Asp Pro Asp Glu Gly Thr Asn Ala Gln Ile Met Tyr Gln Ile 
945                 950                 955                 960 


Val Glu Gly Asn Ile Pro Glu Val Phe Gln Leu Asp Ile Phe Ser Gly 
                965                 970                 975     


Glu Leu Thr Ala Leu Val Asp Leu Asp Tyr Glu Asp Arg Pro Glu Tyr 
            980                 985                 990         


Val Leu Val Ile Gln Ala Thr Ser  Ala Pro Leu Val Ser  Arg Ala Thr 
        995                 1000                 1005             


Val His  Val Arg Leu Leu Asp  Arg Asn Asp Asn Pro  Pro Val Leu 
    1010                 1015                 1020             


Gly Asn  Phe Glu Ile Leu Phe  Asn Asn Tyr Val Thr  Asn Arg Ser 
    1025                 1030                 1035             


Ser Ser  Phe Pro Gly Gly Ala  Ile Gly Arg Val Pro  Ala His Asp 
    1040                 1045                 1050             


Pro Asp  Ile Ser Asp Ser Leu  Thr Tyr Ser Phe Glu  Arg Gly Asn 
    1055                 1060                 1065             


Glu Leu  Ser Leu Val Leu Leu  Asn Ala Ser Thr Gly  Glu Leu Lys 
    1070                 1075                 1080             


Leu Ser  Arg Ala Leu Asp Asn  Asn Arg Pro Leu Glu  Ala Ile Met 
    1085                 1090                 1095             


Ser Val  Leu Val Ser Asp Gly  Val His Ser Val Thr  Ala Gln Cys 
    1100                 1105                 1110             


Ala Leu  Arg Val Thr Ile Ile  Thr Asp Glu Met Leu  Thr His Ser 
    1115                 1120                 1125             


Ile Thr  Leu Arg Leu Glu Asp  Met Ser Pro Glu Arg  Phe Leu Ser 
    1130                 1135                 1140             


Pro Leu  Leu Gly Leu Phe Ile  Gln Ala Val Ala Ala  Thr Leu Ala 
    1145                 1150                 1155             


Thr Pro  Pro Asp His Val Val  Val Phe Asn Val Gln  Arg Asp Thr 
    1160                 1165                 1170             


Asp Ala  Pro Gly Gly His Ile  Leu Asn Val Ser Leu  Ser Val Gly 
    1175                 1180                 1185             


Gln Pro  Pro Gly Pro Gly Gly  Gly Pro Pro Phe Leu  Pro Ser Glu 
    1190                 1195                 1200             


Asp Leu  Gln Glu Arg Leu Tyr  Leu Asn Arg Ser Leu  Leu Thr Ala 
    1205                 1210                 1215             


Ile Ser  Ala Gln Arg Val Leu  Pro Phe Asp Asp Asn  Ile Cys Leu 
    1220                 1225                 1230             


Arg Glu  Pro Cys Glu Asn Tyr  Met Arg Cys Val Ser  Val Leu Arg 
    1235                 1240                 1245             


Phe Asp  Ser Ser Ala Pro Phe  Ile Ala Ser Ser Ser  Val Leu Phe 
    1250                 1255                 1260             


Arg Pro  Ile His Pro Val Gly  Gly Leu Arg Cys Arg  Cys Pro Pro 
    1265                 1270                 1275             


Gly Phe  Thr Gly Asp Tyr Cys  Glu Thr Glu Val Asp  Leu Cys Tyr 
    1280                 1285                 1290             


Ser Arg  Pro Cys Gly Pro His  Gly Arg Cys Arg Ser  Arg Glu Gly 
    1295                 1300                 1305             


Gly Tyr  Thr Cys Leu Cys Arg  Asp Gly Tyr Thr Gly  Glu His Cys 
    1310                 1315                 1320             


Glu Val  Ser Ala Arg Ser Gly  Arg Cys Thr Pro Gly  Val Cys Lys 
    1325                 1330                 1335             


Asn Gly  Gly Thr Cys Val Asn  Leu Leu Val Gly Gly  Phe Lys Cys 
    1340                 1345                 1350             


Asp Cys  Pro Ser Gly Asp Phe  Glu Lys Pro Tyr Cys  Gln Val Thr 
    1355                 1360                 1365             


Thr Arg  Ser Phe Pro Ala His  Ser Phe Ile Thr Phe  Arg Gly Leu 
    1370                 1375                 1380             


Arg Gln  Arg Phe His Phe Thr  Leu Ala Leu Ser Phe  Ala Thr Lys 
    1385                 1390                 1395             


Glu Arg  Asp Gly Leu Leu Leu  Tyr Asn Gly Arg Phe  Asn Glu Lys 
    1400                 1405                 1410             


His Asp  Phe Val Ala Leu Glu  Val Ile Gln Glu Gln  Val Gln Leu 
    1415                 1420                 1425             


Thr Phe  Ser Ala Gly Glu Ser  Thr Thr Thr Val Ser  Pro Phe Val 
    1430                 1435                 1440             


Pro Gly  Gly Val Ser Asp Gly  Gln Trp His Thr Val  Gln Leu Lys 
    1445                 1450                 1455             


Tyr Tyr  Asn Lys Pro Leu Leu  Gly Gln Thr Gly Leu  Pro Gln Gly 
    1460                 1465                 1470             


Pro Ser  Glu Gln Lys Val Ala  Val Val Thr Val Asp  Gly Cys Asp 
    1475                 1480                 1485             


Thr Gly  Val Ala Leu Arg Phe  Gly Ser Val Leu Gly  Asn Tyr Ser 
    1490                 1495                 1500             


Cys Ala  Ala Gln Gly Thr Gln  Gly Gly Ser Lys Lys  Ser Leu Asp 
    1505                 1510                 1515             


Leu Thr  Gly Pro Leu Leu Leu  Gly Gly Val Pro Asp  Leu Pro Glu 
    1520                 1525                 1530             


Ser Phe  Pro Val Arg Met Arg  Gln Phe Val Gly Cys  Met Arg Asn 
    1535                 1540                 1545             


Leu Gln  Val Asp Ser Arg His  Ile Asp Met Ala Asp  Phe Ile Ala 
    1550                 1555                 1560             


Asn Asn  Gly Thr Val Pro Gly  Cys Pro Ala Lys Lys  Asn Val Cys 
    1565                 1570                 1575             


Asp Ser  Asn Thr Cys His Asn  Gly Gly Thr Cys Val  Asn Gln Trp 
    1580                 1585                 1590             


Asp Ala  Phe Ser Cys Glu Cys  Pro Leu Gly Phe Gly  Gly Lys Ser 
    1595                 1600                 1605             


Cys Ala  Gln Glu Met Ala Asn  Pro Gln His Phe Leu  Gly Ser Ser 
    1610                 1615                 1620             


Leu Val  Ala Trp His Gly Leu  Ser Leu Pro Ile Ser  Gln Pro Trp 
    1625                 1630                 1635             


Tyr Leu  Ser Leu Met Phe Arg  Thr Arg Gln Ala Asp  Gly Val Leu 
    1640                 1645                 1650             


Leu Gln  Ala Ile Thr Arg Gly  Arg Ser Thr Ile Thr  Leu Gln Leu 
    1655                 1660                 1665             


Arg Glu  Gly His Val Met Leu  Ser Val Glu Gly Thr  Gly Leu Gln 
    1670                 1675                 1680             


Ala Ser  Ser Leu Arg Leu Glu  Pro Gly Arg Ala Asn  Asp Gly Asp 
    1685                 1690                 1695             


Trp His  His Ala Gln Leu Ala  Leu Gly Ala Ser Gly  Gly Pro Gly 
    1700                 1705                 1710             


His Ala  Ile Leu Ser Phe Asp  Tyr Gly Gln Gln Arg  Ala Glu Gly 
    1715                 1720                 1725             


Asn Leu  Gly Pro Arg Leu His  Gly Leu His Leu Ser  Asn Ile Thr 
    1730                 1735                 1740             


Val Gly  Gly Ile Pro Gly Pro  Ala Gly Gly Val Ala  Arg Gly Phe 
    1745                 1750                 1755             


Arg Gly  Cys Leu Gln Gly Val  Arg Val Ser Asp Thr  Pro Glu Gly 
    1760                 1765                 1770             


Val Asn  Ser Leu Asp Pro Ser  His Gly Glu Ser Ile  Asn Val Glu 
    1775                 1780                 1785             


Gln Gly  Cys Ser Leu Pro Asp  Pro Cys Asp Ser Asn  Pro Cys Pro 
    1790                 1795                 1800             


Ala Asn  Ser Tyr Cys Ser Asn  Asp Trp Asp Ser Tyr  Ser Cys Ser 
    1805                 1810                 1815             


Cys Asp  Pro Gly Tyr Tyr Gly  Asp Asn Cys Thr Asn  Val Cys Asp 
    1820                 1825                 1830             


Leu Asn  Pro Cys Glu His Gln  Ser Val Cys Thr Arg  Lys Pro Ser 
    1835                 1840                 1845             


Ala Pro  His Gly Tyr Thr Cys  Glu Cys Pro Pro Asn  Tyr Leu Gly 
    1850                 1855                 1860             


Pro Tyr  Cys Glu Thr Arg Ile  Asp Gln Pro Cys Pro  Arg Gly Trp 
    1865                 1870                 1875             


Trp Gly  His Pro Thr Cys Gly  Pro Cys Asn Cys Asp  Val Ser Lys 
    1880                 1885                 1890             


Gly Phe  Asp Pro Asp Cys Asn  Lys Thr Ser Gly Glu  Cys His Cys 
    1895                 1900                 1905             


Lys Glu  Asn His Tyr Arg Pro  Pro Gly Ser Pro Thr  Cys Leu Leu 
    1910                 1915                 1920             


Cys Asp  Cys Tyr Pro Thr Gly  Ser Leu Ser Arg Val  Cys Asp Pro 
    1925                 1930                 1935             


Glu Asp  Gly Gln Cys Pro Cys  Lys Pro Gly Val Ile  Gly Arg Gln 
    1940                 1945                 1950             


Cys Asp  Arg Cys Asp Asn Pro  Phe Ala Glu Val Thr  Thr Asn Gly 
    1955                 1960                 1965             


Cys Glu  Val Asn Tyr Asp Ser  Cys Pro Arg Ala Ile  Glu Ala Gly 
    1970                 1975                 1980             


Ile Trp  Trp Pro Arg Thr Arg  Phe Gly Leu Pro Ala  Ala Ala Pro 
    1985                 1990                 1995             


Cys Pro  Lys Gly Ser Phe Gly  Thr Ala Val Arg His  Cys Asp Glu 
    2000                 2005                 2010             


His Arg  Gly Trp Leu Pro Pro  Asn Leu Phe Asn Cys  Thr Ser Ile 
    2015                 2020                 2025             


Thr Phe  Ser Glu Leu Lys Gly  Phe Ala Glu Arg Leu  Gln Arg Asn 
    2030                 2035                 2040             


Glu Ser  Gly Leu Asp Ser Gly  Arg Ser Gln Gln Leu  Ala Leu Leu 
    2045                 2050                 2055             


Leu Arg  Asn Ala Thr Gln His  Thr Ala Gly Tyr Phe  Gly Ser Asp 
    2060                 2065                 2070             


Val Lys  Val Ala Tyr Gln Leu  Ala Thr Arg Leu Leu  Ala His Glu 
    2075                 2080                 2085             


Ser Thr  Gln Arg Gly Phe Gly  Leu Ser Ala Thr Gln  Asp Val His 
    2090                 2095                 2100             


Phe Thr  Glu Asn Leu Leu Arg  Val Gly Ser Ala Leu  Leu Asp Thr 
    2105                 2110                 2115             


Ala Asn  Lys Arg His Trp Glu  Leu Ile Gln Gln Thr  Glu Gly Gly 
    2120                 2125                 2130             


Thr Ala  Trp Leu Leu Gln His  Tyr Glu Ala Tyr Ala  Ser Ala Leu 
    2135                 2140                 2145             


Ala Gln  Asn Met Arg His Thr  Tyr Leu Ser Pro Phe  Thr Ile Val 
    2150                 2155                 2160             


Thr Pro  Asn Ile Val Ile Ser  Val Val Arg Leu Asp  Lys Gly Asn 
    2165                 2170                 2175             


Phe Ala  Gly Ala Lys Leu Pro  Arg Tyr Glu Ala Leu  Arg Gly Glu 
    2180                 2185                 2190             


Gln Pro  Pro Asp Leu Glu Thr  Thr Val Ile Leu Pro  Glu Ser Val 
    2195                 2200                 2205             


Phe Arg  Glu Thr Pro Pro Val  Val Arg Pro Ala Gly  Pro Gly Glu 
    2210                 2215                 2220             


Ala Gln  Glu Pro Glu Glu Leu  Ala Arg Arg Gln Arg  Arg His Pro 
    2225                 2230                 2235             


Glu Leu  Ser Gln Gly Glu Ala  Val Ala Ser Val Ile  Ile Tyr Arg 
    2240                 2245                 2250             


Thr Leu  Ala Gly Leu Leu Pro  His Asn Tyr Asp Pro  Asp Lys Arg 
    2255                 2260                 2265             


Ser Leu  Arg Val Pro Lys Arg  Pro Ile Ile Asn Thr  Pro Val Val 
    2270                 2275                 2280             


Ser Ile  Ser Val His Asp Asp  Glu Glu Leu Leu Pro  Arg Ala Leu 
    2285                 2290                 2295             


Asp Lys  Pro Val Thr Val Gln  Phe Arg Leu Leu Glu  Thr Glu Glu 
    2300                 2305                 2310             


Arg Thr  Lys Pro Ile Cys Val  Phe Trp Asn His Ser  Ile Leu Val 
    2315                 2320                 2325             


Ser Gly  Thr Gly Gly Trp Ser  Ala Arg Gly Cys Glu  Val Val Phe 
    2330                 2335                 2340             


Arg Asn  Glu Ser His Val Ser  Cys Gln Cys Asn His  Met Thr Ser 
    2345                 2350                 2355             


Phe Ala  Val Leu Met Asp Val  Ser Arg Arg Glu Asn  Gly Glu Ile 
    2360                 2365                 2370             


Leu Pro  Leu Lys Thr Leu Thr  Tyr Val Ala Leu Gly  Val Thr Leu 
    2375                 2380                 2385             


Ala Ala  Leu Leu Leu Thr Phe  Phe Phe Leu Thr Leu  Leu Arg Ile 
    2390                 2395                 2400             


Leu Arg  Ser Asn Gln His Gly  Ile Arg Arg Asn Leu  Thr Ala Ala 
    2405                 2410                 2415             


Leu Gly  Leu Ala Gln Leu Val  Phe Leu Leu Gly Ile  Asn Gln Ala 
    2420                 2425                 2430             


Asp Leu  Pro Phe Ala Cys Thr  Val Ile Ala Ile Leu  Leu His Phe 
    2435                 2440                 2445             


Leu Tyr  Leu Cys Thr Phe Ser  Trp Ala Leu Leu Glu  Ala Leu His 
    2450                 2455                 2460             


Leu Tyr  Arg Ala Leu Thr Glu  Val Arg Asp Val Asn  Thr Gly Pro 
    2465                 2470                 2475             


Met Arg  Phe Tyr Tyr Met Leu  Gly Trp Gly Val Pro  Ala Phe Ile 
    2480                 2485                 2490             


Thr Gly  Leu Ala Val Gly Leu  Asp Pro Glu Gly Tyr  Gly Asn Pro 
    2495                 2500                 2505             


Asp Phe  Cys Trp Leu Ser Ile  Tyr Asp Thr Leu Ile  Trp Ser Phe 
    2510                 2515                 2520             


Ala Gly  Pro Val Ala Phe Ala  Val Ser Met Ser Val  Phe Leu Tyr 
    2525                 2530                 2535             


Ile Leu  Ala Ala Arg Ala Ser  Cys Ala Ala Gln Arg  Gln Gly Phe 
    2540                 2545                 2550             


Glu Lys  Lys Gly Pro Val Ser  Gly Leu Gln Pro Ser  Phe Ala Val 
    2555                 2560                 2565             


Leu Leu  Leu Leu Ser Ala Thr  Trp Leu Leu Ala Leu  Leu Ser Val 
    2570                 2575                 2580             


Asn Ser  Asp Thr Leu Leu Phe  His Tyr Leu Phe Ala  Thr Cys Asn 
    2585                 2590                 2595             


Cys Ile  Gln Gly Pro Phe Ile  Phe Leu Ser Tyr Val  Val Leu Ser 
    2600                 2605                 2610             


Lys Glu  Val Arg Lys Ala Leu  Lys Leu Ala Cys Ser  Arg Lys Pro 
    2615                 2620                 2625             


Ser Pro  Asp Pro Ala Leu Thr  Thr Lys Ser Thr Leu  Thr Ser Ser 
    2630                 2635                 2640             


Tyr Asn  Cys Pro Ser Pro Tyr  Ala Asp Gly Arg Leu  Tyr Gln Pro 
    2645                 2650                 2655             


Tyr Gly  Asp Ser Ala Gly Ser  Leu His Ser Thr Ser  Arg Ser Gly 
    2660                 2665                 2670             


Lys Ser  Gln Pro Ser Tyr Ile  Pro Phe Leu Leu Arg  Glu Glu Ser 
    2675                 2680                 2685             


Ala Leu  Asn Pro Gly Gln Gly  Pro Pro Gly Leu Gly  Asp Pro Gly 
    2690                 2695                 2700             


Ser Leu  Phe Leu Glu Gly Gln  Asp Gln Gln His Asp  Pro Asp Thr 
    2705                 2710                 2715             


Asp Ser  Asp Ser Asp Leu Ser  Leu Glu Asp Asp Gln  Ser Gly Ser 
    2720                 2725                 2730             


Tyr Ala  Ser Thr His Ser Ser  Asp Ser Glu Glu Glu  Glu Glu Glu 
    2735                 2740                 2745             


Glu Glu  Glu Glu Ala Ala Phe  Pro Gly Glu Gln Gly  Trp Asp Ser 
    2750                 2755                 2760             


Leu Leu  Gly Pro Gly Ala Glu  Arg Leu Pro Leu His  Ser Thr Pro 
    2765                 2770                 2775             


Lys Asp  Gly Gly Pro Gly Pro  Gly Lys Ala Pro Trp  Pro Gly Asp 
    2780                 2785                 2790             


Phe Gly  Thr Thr Ala Lys Glu  Ser Ser Gly Asn Gly  Ala Pro Glu 
    2795                 2800                 2805             


Glu Arg  Leu Arg Glu Asn Gly  Asp Ala Leu Ser Arg  Glu Gly Ser 
    2810                 2815                 2820             


Leu Gly  Pro Leu Pro Gly Ser  Ser Ala Gln Pro His  Lys Gly Ile 
    2825                 2830                 2835             


Leu Lys  Lys Lys Cys Leu Pro  Thr Ile Ser Glu Lys  Ser Ser Leu 
    2840                 2845                 2850             


Leu Arg  Leu Pro Leu Glu Gln  Cys Thr Gly Ser Ser  Arg Gly Ser 
    2855                 2860                 2865             


Ser Ala  Ser Glu Gly Ser Arg  Gly Gly Pro Pro Pro  Arg Pro Pro 
    2870                 2875                 2880             


Pro Arg  Gln Ser Leu Gln Glu  Gln Leu Asn Gly Val  Met Pro Ile 
    2885                 2890                 2895             


Ala Met  Ser Ile Lys Ala Gly  Thr Val Asp Glu Asp  Ser Ser Gly 
    2900                 2905                 2910             


Ser Glu  Phe Leu Phe Phe Asn  Phe Leu His 
    2915                 2920             


<210>  11
<211>  2091
<212>  DNA
<213>  Homo sapiens

<400>  11
cgctgtgccc cgattccgcg tcgggctgcg cgggcggcca gcggttcagg cgcgcgcgga       60

gagctctggc tcagagtttg cgatccgaga gcgggatccg cgctccctcg gtccttcctc      120

cctcccctct tgcggcctcc cgctgtcatc tggagccgct cctgccgccc cctggcggcg      180

accgcgggaa gggccggccc ccatccgcac ccctgacccc ggaggtcaac aacgggatgg      240

tccctgggtc ccaggggaag agacatcacc cagtaggagg gagtacggtc tagacagagg      300

ccacgagggc gggagggggc gagagtggag agtggcccag ctggccaggg tcgtctaagt      360

gagaggaaaa gggagagggc ggttgagacc aggccctgaa ttccgcgttc atcttatcct      420

gaggtctgtg gggacctgtt gaaggactgg ggcaggggac ggacgcgggc atccttccat      480

ttggaacagc cattccggca gcatcaggat ggggcggagg caaagcgggg agtgggcgag      540

gcaagtggtg ctgtaaacct gtgcgagaag ggggcggtga ctctaagggc aggaaggagc      600

cctggtcaca cacacactcc cacgcaaggt attcagtgcc gagtgtggcc ttggtgctag      660

gattcaaaga ggaaaggaag aaaactttcc attctaaaag aaactccacg tgaggcgaag      720

aagatgaaat atagtcagaa aaccatacca gtaggtggta gttaagttga taaatgatgc      780

atacgacatc ctatagaaga ctgtcaccac cccacctcac tgatcagccc tctgcctaca      840

gccacaccca cagaacattc agccatttct cctgtggttc ccagcctgca gcacagcgtc      900

tgcacgtgga actctggaat gctgacctac agtctgagtt cctgtgccct tgcctggggc      960

tgactctcta cttgacctgt aacccacaac tgggcaagag aaaattctgc agccacagct     1020

ctgaggacat gagcaaaatg gtttccagac ggaatgtcaa ggattcccat gaagtgtcag     1080

ggagtcttca ggccacactt caggttatct ccttctcttt cccttttctg cttcacactt     1140

gctctcatcc tctttctcac cccacatctg gtcagaggag ataggaaggt tcttgttacc     1200

tggtacaaga caacttttgg aatcccagat attcagatta tttccccttt tcctctttgc     1260

aaatgataat actcacagcc aagaggcatc acccggatcc gaggctgctt ctccttagga     1320

catgcagaca gaaggagaag gcggggctgg cagcctccag tccacagcct ccctttcttc     1380

ttccggcgat gattaactag gcctagacaa tggagatcta cggcatacgc ccagggcctc     1440

ctcttctcaa gcatggctga tcagtcactt tcccgtctat ccttcattta ttgaagccaa     1500

ctatgaacga ctaaaggaag gatgagaaaa gtcacccaaa gtcaaagggg acagcgtggg     1560

agactgttct agacagaagg aaacaccttt gcaaagaccc tgaggaaggc aggggactct     1620

ccaggagcag aagggctgtg tggcttcaga gtccacaaaa gagagcagat acaggacact     1680

ggctagagca ggccctggag cccgctgctg tcctggaggc cttggggagg cccagtgttc     1740

ccagggtgga agaagtaggg gacagcttga cgtagtggct gttgatcagc tgatatggaa     1800

gtatgtcatt ttattaacaa ttgagaaagg agtgctgtgc aattccattc aatgccagtg     1860

atgcttatgg ccgtttttat gagttctgtc attttcaaat gagcaagagg aagcctctaa     1920

gggggtttaa gcagggactg acgtaatcag atctgtgttt ttccaaaggg agagggagaa     1980

aaagaacatt tcttattttt caaaaaaggt aatgcaaaag catcattcca caattctctt     2040

gtaatgaaaa aaataaatgc aaacttaagc aaatccatca ttctgaaaga a              2091


<210>  12
<211>  136
<212>  PRT
<213>  Homo sapiens

<400>  12

Met Met His Thr Thr Ser Tyr Arg Arg Leu Ser Pro Pro His Leu Thr 
1               5                   10                  15      


Asp Gln Pro Ser Ala Tyr Ser His Thr His Arg Thr Phe Ser His Phe 
            20                  25                  30          


Ser Cys Gly Ser Gln Pro Ala Ala Gln Arg Leu His Val Glu Leu Trp 
        35                  40                  45              


Asn Ala Asp Leu Gln Ser Glu Phe Leu Cys Pro Cys Leu Gly Leu Thr 
    50                  55                  60                  


Leu Tyr Leu Thr Cys Asn Pro Gln Leu Gly Lys Arg Lys Phe Cys Ser 
65                  70                  75                  80  


His Ser Ser Glu Asp Met Ser Lys Met Val Ser Arg Arg Asn Val Lys 
                85                  90                  95      


Asp Ser His Glu Val Ser Gly Ser Leu Gln Ala Thr Leu Gln Val Ile 
            100                 105                 110         


Ser Phe Ser Phe Pro Phe Leu Leu His Thr Cys Ser His Pro Leu Ser 
        115                 120                 125             


His Pro Thr Ser Gly Gln Arg Arg 
    130                 135     


<210>  13
<211>  3715
<212>  DNA
<213>  Homo sapiens

<400>  13
cctaccccag ctctcgcgcc gcgtgcagag gtgctcaagc ctcctcgcgg tccgcagtca       60

gtgccgccgc gcccggcctc ccgcacgccc cgcaggtagc gcccccgccc gcggcccaga      120

gtgcgctcgc gccggcacca gctcccggat aaacggcgcg ccgcgcggag atgacagccg      180

aggagatgaa ggcgaccgag agcggggcgc agtcggcgcc gctgcccatg gagggagtgg      240

acatcagccc caaacaggac gaaggcgtgc tgaaggtcat caagagagag ggcacaggta      300

cagagatgcc catgattggg gaccgagtct ttgtccacta cactggctgg ctattagatg      360

gcacaaagtt tgactccagt ctggatcgca aggacaaatt ctcctttgac ctgggaaaag      420

gggaggtcat caaggcttgg gacattgcca tagccaccat gaaggtgggg gaggtgtgcc      480

acatcacctg caaaccagaa tatgcctacg gttcagcagg cagtcctcca aagattcccc      540

ccaatgccac gcttgtattt gaggtggagt tgtttgagtt taagggagaa gatctgacgg      600

aagaggaaga tggcggaatc attcgcagaa tacagactcg cggtgaaggc tatgctaagc      660

ccaatgaggg tgctatcgtg gaggttgcac tggaagggta ctacaaggac aagctctttg      720

accagcggga gctccgcttt gagattggcg agggggagaa cctggatctg ccttatggtc      780

tggagagggc cattcagcgc atggagaaag gagaacattc catcgtgtac ctcaagccca      840

gctatgcttt tggcagtgtt gggaaggaaa agttccaaat cccaccaaat gctgagctga      900

aatatgaatt acacctcaag agttttgaaa aggccaagga gtcttgggag atgaattcag      960

aagagaagct ggaacagagc accatagtga aagagcgggg cactgtgtac ttcaaggaag     1020

gtaaatacaa gcaagcttta ctacagtata agaagatcgt gtcttggctg gaatatgagt     1080

ctagtttttc caatgaggaa gcacagaaag cacaggccct tcgactggcc tctcacctca     1140

acctggccat gtgtcatctg aaactacagg ccttctctgc tgccattgaa agctgtaaca     1200

aggccctaga actggacagc aacaacgaga agggcctctt ccgccgggga gaggcccacc     1260

tggccgtgaa tgactttgaa ctggcacggg ctgatttcca gaaggtcctg cagctctacc     1320

ccaacaacaa agccgccaag acccagctgg ctgtgtgcca gcagcggatc cgaaggcagc     1380

ttgcccggga gaagaagctc tatgccaata tgtttgagag gctggctgag gaggagaaca     1440

aggccaaggc agaggcttcc tcaggagacc atcccactga cacagagatg aaggaggagc     1500

agaagagcaa cacggcaggg agccagtctc aggtggagac agaagcatag cccctctcca     1560

ccagccctac tcctgcggct gcctgccccc cagtctcccc actccaccct gttagttttg     1620

taaaaactga agaattttga gtgaattaga cctttatttt tctatctggt tggatggtgg     1680

ctttagggga agggggaaag gtgtaggctg ggggattgag gtggggaatc attttagctg     1740

gtgtcagccc ctcttccctt cctccattgc acatgaacat atgtccatcc atatatattc     1800

atcagaatgt taatttattt tgctccctct gttaggtcca ttttctaagg gtagaagagg     1860

caagtggtag ggatgaggtc tgataagaac ccagggtgga gagggagact cctgggcagc     1920

cgttttcctc atcctttccc tctcccagtc catttccaaa tgtggcctcc atgtgggtgc     1980

tagggacatg ggaaaaacca ctgctatgcc atttcttctc tctgttccct tcctcacccc     2040

cgacggtgtg gctgatgatg tcttctggtg tcatggtgac caccccctgt tccctgttct     2100

ggtatttccc ctgtcagttt cccctctcgg ccaggttgtg tcccaaaatc ccctcagcct     2160

cttctctgca cgttgctgaa ggtccaggct tgcctcaagt tccatgcttg agcaataaag     2220

tggaaacaat aaaacctggg tgtcagacaa ccctttctgt tcagccttgg agtggtgggt     2280

atgggtgggt acataatggg tagtagcaca atcaaggggt cacccactta gttccagttg     2340

agcttaaata agtgagcatc tcatgtagat gccatagttg ggcaggaagc agccccacca     2400

tgcatggctt cctgagcact gcacaggctg ccgctgggat ttgtgtctat ggcttcgccc     2460

aaggttccca gcactccctc cctccagcaa cctggcagtt ttagtgcctc tggttttctt     2520

ccctgacact taggaagacg aaagtataaa gatctagaag actgggacac catgcatgtt     2580

cattttgaag ttggaattgg tcttctgcct acctctgatc tggcagaggt atctgcattt     2640

tggtttgtta acaaggtaaa actcctggtg tcactgacct cctcctgtca gataacttac     2700

atgattaagg ttaagagtaa agcagagtgt tcacgtccag cttccttctc agccttaaca     2760

ggaaaaggct tgtgcttttt ttctaactat gctttgaccc ttaactccta tggcatgatg     2820

gggccctggg agaagccagg cagcacaagc cagtcatgct gagctgcctc cagataatcc     2880

tggctccagg ccagagcccg tgtctgccct catccctctc tcctactgtg agctctccag     2940

tcctttccca acagcgatgt ggttgtctgc ttagccacat gcctgtatag ttccttccag     3000

aagaaatgta taatggtgga agatgtattt ctgtgtgaaa attttcacca agtcatacaa     3060

cacagctgat gctggagcca ggattaaaat tggggtgtac aagtctccca gtgtgagtat     3120

cccttgagcc caagacacca aggatgcaga gaactgtgac tgtgccactg cacgccagcc     3180

tgggcaagag agtgagacca tctctttttt aaaaaagtcc ctgtgtaact gctttcttac     3240

tgggcttacc tcacatcaca gccctgtgtt tgtggtttgt gtctgggtcc tcttggtatt     3300

tcaaaagtag tagattctta cgcctgcagc caacaataat cactaactca agcatttatg     3360

gagtaagcct agcactgtac tgacagcatc acatgagtga aactgaatcc ttgcaaccat     3420

cctacaaaga aggtataact ttaataaccc tatttacaga taagaaaacc aagactcaga     3480

agttaaatgg aaaggtgagg tctctgaact aatccagact ctcccatgag gttcctttgg     3540

caagtcctgg gcttctgtcc tcatctgcaa aatcgaaagc attcctgagg tttcttccag     3600

ctctgcatcc tgtaggattc caagaatgta aaactgcatg taaccgtgga acatctagag     3660

ataagtctta gtttatgtaa cattaaaact gtctagtgag gatgttttgt taaaa          3715


<210>  14
<211>  459
<212>  PRT
<213>  Homo sapiens

<400>  14

Met Thr Ala Glu Glu Met Lys Ala Thr Glu Ser Gly Ala Gln Ser Ala 
1               5                   10                  15      


Pro Leu Pro Met Glu Gly Val Asp Ile Ser Pro Lys Gln Asp Glu Gly 
            20                  25                  30          


Val Leu Lys Val Ile Lys Arg Glu Gly Thr Gly Thr Glu Met Pro Met 
        35                  40                  45              


Ile Gly Asp Arg Val Phe Val His Tyr Thr Gly Trp Leu Leu Asp Gly 
    50                  55                  60                  


Thr Lys Phe Asp Ser Ser Leu Asp Arg Lys Asp Lys Phe Ser Phe Asp 
65                  70                  75                  80  


Leu Gly Lys Gly Glu Val Ile Lys Ala Trp Asp Ile Ala Ile Ala Thr 
                85                  90                  95      


Met Lys Val Gly Glu Val Cys His Ile Thr Cys Lys Pro Glu Tyr Ala 
            100                 105                 110         


Tyr Gly Ser Ala Gly Ser Pro Pro Lys Ile Pro Pro Asn Ala Thr Leu 
        115                 120                 125             


Val Phe Glu Val Glu Leu Phe Glu Phe Lys Gly Glu Asp Leu Thr Glu 
    130                 135                 140                 


Glu Glu Asp Gly Gly Ile Ile Arg Arg Ile Gln Thr Arg Gly Glu Gly 
145                 150                 155                 160 


Tyr Ala Lys Pro Asn Glu Gly Ala Ile Val Glu Val Ala Leu Glu Gly 
                165                 170                 175     


Tyr Tyr Lys Asp Lys Leu Phe Asp Gln Arg Glu Leu Arg Phe Glu Ile 
            180                 185                 190         


Gly Glu Gly Glu Asn Leu Asp Leu Pro Tyr Gly Leu Glu Arg Ala Ile 
        195                 200                 205             


Gln Arg Met Glu Lys Gly Glu His Ser Ile Val Tyr Leu Lys Pro Ser 
    210                 215                 220                 


Tyr Ala Phe Gly Ser Val Gly Lys Glu Lys Phe Gln Ile Pro Pro Asn 
225                 230                 235                 240 


Ala Glu Leu Lys Tyr Glu Leu His Leu Lys Ser Phe Glu Lys Ala Lys 
                245                 250                 255     


Glu Ser Trp Glu Met Asn Ser Glu Glu Lys Leu Glu Gln Ser Thr Ile 
            260                 265                 270         


Val Lys Glu Arg Gly Thr Val Tyr Phe Lys Glu Gly Lys Tyr Lys Gln 
        275                 280                 285             


Ala Leu Leu Gln Tyr Lys Lys Ile Val Ser Trp Leu Glu Tyr Glu Ser 
    290                 295                 300                 


Ser Phe Ser Asn Glu Glu Ala Gln Lys Ala Gln Ala Leu Arg Leu Ala 
305                 310                 315                 320 


Ser His Leu Asn Leu Ala Met Cys His Leu Lys Leu Gln Ala Phe Ser 
                325                 330                 335     


Ala Ala Ile Glu Ser Cys Asn Lys Ala Leu Glu Leu Asp Ser Asn Asn 
            340                 345                 350         


Glu Lys Gly Leu Phe Arg Arg Gly Glu Ala His Leu Ala Val Asn Asp 
        355                 360                 365             


Phe Glu Leu Ala Arg Ala Asp Phe Gln Lys Val Leu Gln Leu Tyr Pro 
    370                 375                 380                 


Asn Asn Lys Ala Ala Lys Thr Gln Leu Ala Val Cys Gln Gln Arg Ile 
385                 390                 395                 400 


Arg Arg Gln Leu Ala Arg Glu Lys Lys Leu Tyr Ala Asn Met Phe Glu 
                405                 410                 415     


Arg Leu Ala Glu Glu Glu Asn Lys Ala Lys Ala Glu Ala Ser Ser Gly 
            420                 425                 430         


Asp His Pro Thr Asp Thr Glu Met Lys Glu Glu Gln Lys Ser Asn Thr 
        435                 440                 445             


Ala Gly Ser Gln Ser Gln Val Glu Thr Glu Ala 
    450                 455                 


<210>  15
<211>  13546
<212>  DNA
<213>  Homo sapiens

<400>  15
ggaggtcggc gcagctgccc ctttgggctt tggctctgga ctggagcgca gcatccttcg       60

aggctgcagc cgccacggct gttgccgtaa gcaatcctcc tgcctcagcc tcccgagtag      120

ctgggactcg ggaccagcct cccgagtatt ggtcagatga catttaccat caccgttttc      180

ttcttctttc atcatcatca tcatcaccat tgccactacc accacctcca aggccactac      240

caccacagca tctctgttcc tccatcagag ctcttcaagt tctgtaaagg cagattctct      300

aaaggcatgc ctggtggcat cacgtttttc acatctccgc atctggaccc tgcccaagcg      360

aaggctgatc taggcagtct cattgctgga gatgactgtc agctgctttc tctgcatagc      420

caccatcaca tgcctcacca ctggagcctg ggaagcctga ccacaaaccg gcatctccaa      480

ggcatgaata attaggtagg cataatggaa ggcactcatt gtaccctcca attgcataag      540

cccattacgg aactctgcta catcagcttc tgtcttccaa agggggaagt cagaggattt      600

tcatacaagg gcactgtaac tctagacaga tccaataaag gttttcataa ctgctaccaa      660

gtcagggagg agtcagacat catcagcctc agccaggagc cggacgaaca tccaggcgac      720

atatttttca agcagactcc cacgaaagac attctaactg agctgtacaa actcacaaca      780

gagagggaga gactgctaac caatctcctg agctcagacc acatcctggg gatcacgatg      840

gggaaccagg aggggaagct gcaagagctg tccgtgagcc tggcccccga ggatgactgt      900

ttccagagtg ctggtgactg gcagggagag ctccccgtgg gccctctcaa taagaggagc      960

acccacggga acaaaaagcc tcggaggtct agtggaagga gagagagctt tggggccctt     1020

ccacagaaga ggaccaaaag aaaagggcgt ggaggccgag aatcagctcc tctgatgggc     1080

aaggacaaga tctgttccag ccactccctt cctctttcta gaacaaggcc taacctttgg     1140

gtactagagg agaaaggaaa tctgctcccg aatggggcac ttgcctgctc cctgcagagg     1200

agagagagct gccccccaga tattcccaag acgccagaca cagaccttgg ctttgggagc     1260

tttgagacgg ctttcaagga cactgggctt ggaagagaag tgctgccccc tgactgcagc     1320

tccacagagg caggagggga tggcattcgg aggccgccga gcgggctgga gcatcagcaa     1380

acaggtttgt ctgaaagtca ccaggaccct gagaagcatc cagaggcaga aaaggatgag     1440

atggagaagc cggctaagcg gacttgcaag cagaaacctg tctccaaagt ggtggccaaa     1500

gttcaggacc tgtcctccca ggtacaaaga gtagttaaaa cgcattctaa gggtaaggag     1560

acgattgcca ttcgcccagc agcccacgct gagtttgtac ccaaagccga cttgctcacc     1620

ctcccgggag ctgaggctgg ggctcatggc tccaggcggc agggcaagga gcggcaaggg     1680

gataggtcat cgcagtcgcc agccggggaa acagcctcca tttctagtgt gtcggccagt     1740

gccgaggggg ccgtgaacaa ggtccccctg aaggtgatag agagtgagaa gttagatgaa     1800

gcccctgagg ggaaaagact gggcttccct gtccacacga gtgtccctca cactcgccca     1860

gaaacgagaa acaagaggag agccgggttg ccccttggtg gccacaagtc cttgtttctg     1920

gatctgcccc acaaagtagg tcctgactcc tcacaaccca gaggtgataa gaagaagcca     1980

tccccaccag caccggcagc tcttggcaag gtgtttaata attcagcctc gcagtccagc     2040

acacacaaac agacgtcacc tgttccctcg cctctgtctc caaggctccc cagccctcag     2100

cagcatcaca ggatcctccg gctccctgca ttgcctggtg agagggaagc tgctcttaat     2160

gactctcctt gtagaaagag ccgtgtcttc tctgggtgcg tctctgctga caccttggag     2220

ccaccatcct ctgcaaaggt cacggagacc aaaggagcca gcccggcctt cctcagagca     2280

ggccaacctc ggttggtgcc tggggaaact ttggaaaaga gcttggggcc agggaagacc     2340

acagctgagc cccagcacca gtcacctcca ggtatctcct ctgagggctt tccctgggac     2400

ggcttcaatg agcagacacc taaagacctt cccaacagag atggaggcgc gtgggttctg     2460

ggctacagag cgggaccagc ctgtccattt ttgcttcatg aggaaaggga gaagtcaaac     2520

aggagcgaat tgtacttgga tctccatcct gaccacagcc tgactgagca ggatgacagg     2580

actcctggca gacttcaagc tgtctggcca cccccaaaga caaaagacac agaagaaaaa     2640

gtgggactga agtacactga agcagaatac caagctgcta ttttacactt gaagagggag     2700

cacaaagaag aaattgaaaa cctgcaggca cagtttgaac ttcgggcatt tcatatccgg     2760

ggcgagcatg caatgataac agcgagacta gaagaaacca ttgaaaatct gaaacacgag     2820

ctagaacaca gatggcgagg gggttgtgaa gagaggaaag atgtgtgcat ttccaccgat     2880

gatgactgcc ctccaaagac cttcagaaat gtgtgcgtcc agacagacag agagaccttc     2940

ctcaagccct gtgaaagtga aagcaagaca accagaagta atcaattagt acccaaaaag     3000

ctgaatatct cctctttaag ccagctctca cccccaaatg accacaaaga catccatgca     3060

gcactccagc caatggaggg catggcatca aatcagcaga aggcattgcc tccgcctccc     3120

gcatccatcc ctccccctcc gcccctcccc tcaggacttg gatctttgtc tcccgcacct     3180

ccaatgccac ctgtgagtgc tgggccaccg ctaccacctc cgcctcctcc accgccacct     3240

ctacctccac cttcaagtgc tggacctcca ccacccccac ccccaccccc acttcctaac     3300

tcccctgccc cacccaaccc tggagggcct cctcctgctc caccaccccc aggacttgca     3360

cccccacctc cccctggact cttctttgga cttggctctt cttccagtca atgtcctcga     3420

aaaccagcca tcgagcccag ttgtcccatg aagcctttat attggactag gatacaaata     3480

agtgatagga gccaaaatgc tacaccaacc ttatgggact ccttagaaga acctgacatt     3540

cgggacccca gtgaatttga gtatttattc tccaaagaca caactcaaca gaagaaaaaa     3600

cctctgtcag agacttatga gaagaaaaac aaggtcaaaa agatcatcaa attgttggat     3660

ggaaaacgat ctcaaactgt gggaatcttg atatctagtt tacatttaga aatgaaggat     3720

atccaacagg ccattttcaa tgtggatgac tccgtggttg atctggagac cctggcagcc     3780

ttatatgaaa acagagccca agaggatgag ctggttaaaa taagaaagta ttacgagaca     3840

tccaaagaag aagaactgaa gctgctggat aaacctgagc aatttttaca tgagttagcc     3900

cagattccta attttgctga acgtgcccag tgcataatct tcagatctgt cttttctgag     3960

ggtatcacct ccttgcacag aaaggtagag atcatcacgc gagcttctaa ggacttgctg     4020

cacgtgaaga gcgtgaagga tattttagct ctcatcttgg cttttggaaa ttatatgaat     4080

ggaggaaata ggactcgggg acaagccgat ggatatagct tagaaattct gcccaaactc     4140

aaggatgtca aaagtcggga taatgggatt aatctggtgg actacgttgt taagtattac     4200

ctgcgttact atgatcagga agctggaaca gaaaagagtg ttttcccctt gccggaacca     4260

caggatttct ttctggcctc ccaagtcaag tttgaagacc tcataaaaga tttgagaaaa     4320

ctgaagaggc aactagaagc aagtgagaaa cagatggtgg tggtgtgcaa ggagtcccca     4380

aaggagtatc tccagccttt caaggacaaa ctagaggagt tcttccaaaa agccaaaaaa     4440

gagcataaga tggaagaaag tcacttggag aatgcacaga aaagttttga aacaacagta     4500

cgatattttg ggatgaagcc aaagtctggt gagaaggaga tcacacccag ctacgtgttt     4560

atggtgtggt atgagttctg cagtgacttc aagacaattt ggaaacggga gagtaaaaac     4620

atatctaaag aaagattgaa aatggctcag gaatcagtca gcaagttgac ttcagagaag     4680

aaagtggaga caaagaaaat caatcccact gctagcctga aagaaagact gcgtcagaag     4740

gaagccagtg tgaccactaa ctaagatgaa gacacatgga aatgatggca ctggaggtgg     4800

aggaccttgc acgcatactc tttgtgacca cagggttgca ggacgttctt gaaagatgtg     4860

tcactaaatg tttgtttttg ctcatctctt tctgaggtca tctgcagaga gtgccccatg     4920

ccttctttaa gaagtccctc attaagccgc aggaacaatg gaaaactatt taagggaaca     4980

ttgcagaaat atttgatgac tgtttcttgt ggaagcccaa agtccactct aagagcagaa     5040

gaaataccaa aatgtttcca aaattttttt aaaagctgag atttccagct ttataaccaa     5100

agcttgatat atgtcacatt gtcacagaag agagaaaaga tcattgagga cagttgcctt     5160

gggagagttc aagtctttgt cgttacacac tgctgttttg attattggtc ttagttttga     5220

tcctgttgca gcaaaatcct gcagcatctt tctctccaat aatgttgcaa ctcaccaaaa     5280

ctattcttga agaggtccaa gaacatgtat tatccagact aaaaaaatga ttttttgttg     5340

ttatggttta cgtgatgaaa aggagaaaaa acagaatcat acctgggtgg agagagggag     5400

acaaatagcc ataaacttca tcctggagaa caagttacca tgcaaggagt tgacatcagt     5460

tgttaagtga ggcccattct tgtttttaca tcggtccttt gtggtttttc tgggccagca     5520

gagattctgc accccaactc ccaggagaaa atgtaatacc tgagcaagca cagccttggg     5580

tgtgcttgga caagagaccc agcggcagag caccttttac attttggacc gttcatgaat     5640

gggcaatgtt gtgttgatac gcagccgagt tctacgttat gtgctgtgac tgtgcagctg     5700

gacgaccccc atccccagga ggcagtttcc agacaggaga gcaaatgcaa ctcacagcac     5760

ctgctcatga ccttggctga taggcatgtg aagtaggatg aagcaggact ctttaatgtc     5820

aaaaaaactg aagggcagaa aaaaggttcc ttacatcaaa atgaaagtaa ttacattaat     5880

agaaaacttc caagtggaat attgttcaca ggcagctctt tctgaccctg gctcttgagt     5940

cacataagga aaccaccttt gacctctctg acacttttgt ctttaagcca cgtctctgaa     6000

atcttgtgag gggtgaagaa agaggactgg agatgaatgg acaatatgat caaagactca     6060

tttttaggcc ttgaagaggc cgagctttct ccccccaatt ggtggaggac agtccagaga     6120

tgagcagaaa tcttaaattc cttcctgatc cagcctccac atgtggcctg ccccttgccc     6180

cagcatcttt ccagaacccc tggacttgcc aggtgcctga gcatcttccc aggatatgcc     6240

tgccagccag cagcccctca ggaatgcttc tataatagat ccagtaatga aagcagcacc     6300

atatcctaat ctaatgtcag cttcgagaat gaagactgca gtcaggatca aatcaagtca     6360

cagaagccat attcatgcag gtgctaaccg ccttttctac tggtgcaact gaaaggaata     6420

tggtaacatg gttggatttt taaaattcac aatgaaggaa cgagacaagc aaaacagaaa     6480

agccgagaag gaacatgcat gactaaaaag gcttgaagtt gcttgtgagc aagaagcttt     6540

ttatgctgct ttcttacata gtttctcttc attttcactt aactctgaag acaaccaaaa     6600

gaacggatca attaaaaact gattccactt ataaccattg tatgctcctt ctagtgttat     6660

catgcacaag aaaagtgcca gttttaccca tgccatataa ttcagctctt ttgagttatg     6720

tggggccagc agaagtctca atccttatag gcttgatggt gagagcagcg ggaggtttga     6780

ggtgtactca ttgcagtcca ctttggtctg taagtaggat gcttacgaga aatcagtgaa     6840

ggtaagcagg gctgccactg tggccacgta acccttcagg aaccagtgct gaagaataat     6900

gagtgagaac acttaatttg agagttagac aaatacagcc cactttggat ttcatcctag     6960

tgaacagact aaaactttgc agtaaaatac ctatttctac aaagcaaggt ttgcctgcct     7020

cggttgggga aacctagtgg ttttgtcaca ctagtcgatg tatgatgtta gtgttgtaag     7080

acaccatggc agaatcttca ttattctcac ctattctgaa ccctgcatca tgtatctggg     7140

atgccccctc ccaagtccac caatgtacca cgttgctgac acagccttca tttttaactc     7200

aaattgatgc tcagtaaagg tcaatgacaa tttgttcaag gaagttcatc taaaataatc     7260

tggaggcctt gaaaatgatc cctctaaaat gctgttgagc ttgtgttcag tgtagcagga     7320

ggatctgaac ttttcctgga gaggaggtga tcgggatgcc atttggcagc ttaagcacat     7380

cctgccagca ggctttaagt ggctgttcta ggcatagccc tccctgaact agaaaggaga     7440

gtaaccagtt tgctatgctg catctaacca gacacacctg acttagtagt aactctaaga     7500

acccttaact tacaaacaac tttgtctcct cttagacaat attcattaaa tctgaggaca     7560

cagtttgaca gtagttcaga ttcttgcatg agcaattgac agcatcagag cacacaatat     7620

cataagttac ataaattaca caaagtacat cataaattac actacagaca cgttaggtaa     7680

aaagcatcag gcccgggccg ggcgtggtgg ctcatgccta taatcccagc actttgggag     7740

gccaagcggg ggcggatcac gaggtcagga gattgagacc atcctggcta acacggtgaa     7800

accccatctc tactaaaaat acaaaaaatt agccgggcgt ggtggtgggc gcctgtagtc     7860

ccagctactc gggaggctga ggcaggagaa tggcgtgaac ccaggaggtg gagcttgcag     7920

ctagccgaga tagcaccact gcactccagc ctgggcgaca gtgagactcc gtttcaaaaa     7980

aaaaagcatc aggcccatga agtatcaaaa accaggttag gaggtgtgct gtatggcttt     8040

tatctcaata agtggcagct tactggggaa aaagaaataa gaaaaagtgt ggccaagcag     8100

aagtggatgt ttatgatgac ggtgggggcc cagaggtcat aggtgatggt cctactgccc     8160

aacagttgcc ttttgaatcc ttatgttgat gatggtgtct ttctacacac tcactgcaac     8220

tactcaggaa ttataaagat tttctgaaat ctgagaagtg gaataaggaa acccagtgga     8280

gctattacac ttttaaatgt tctagccaaa acaaattgcc agtatggttg aggaattgaa     8340

tatcagatgg catgcagtct cccctcccct cccctatcaa ggacagtaga agctgcaaac     8400

ctcttctcag cctccttcag gcacctcctg ttttcataag caccatgaag aatggtgttt     8460

cctaaatgaa aagttcagat actgctggta aagaaactgg aaaaactgaa ggaaggaata     8520

aaatatgttg gtggtattaa cacctccagt aagataagtc attggtacgg tttttctaag     8580

ggccgcagtg agatgtagca gaagaaatat gtttattttg ggcaaagatt tgcttattgg     8640

cctgggattg cacattttct ctatgatgtt tgcaacagag aaattttcat tttaatgata     8700

ctcttccttt cttgaaagtt acatgtcctc atttctgttt ctgcttctcc cttggccagt     8760

gtcattgatg cagatcattg catacaacag cacagcaaat tgcgccaagt cagtgtgtga     8820

atgggaatta gcaatgcacg cttgcaggct ctttttccag gaaccaggct gtaacattga     8880

ccggggaacc tcttcattcc ctgacatact aaattggtca attttgtagt actcatctcc     8940

atccacaaaa acaacaaaga taaaatcaat ttggagcttt atatgacaaa aaggaagaag     9000

tccaaaaata tatagccttc ccccctccca catatctgat ccaaatatta aatatctgat     9060

tttataaaac agtttaaatt gtctttttaa attgctaaca agcatcagtt atatttgagc     9120

ttcatttttc ttttatcctg tctgtcctaa taaaaacaaa aatggccaaa aagtggagag     9180

gaaagaaaaa gcttccactt tttaaaattt gttttgtatt agttatttta cctttaggga     9240

ccctacaact gaagagagtg gagagaataa agaagtgaac tttcattcat gtctgctact     9300

ttgacctcat aaagaaatct gcaacacaga tgaaaccagt ctgtgtggcc aagctgatgg     9360

gatttgaaaa gagtggataa tttttagcct ttccaaaatg caaataactt ggatatattt     9420

ccattttcca gctatagaga gaaacaatcc agctgcctgg aaactgttat tagtatagaa     9480

gtggcttaaa gaaaagcatc ttcaaatact tgacttagca tatctttctt ctttagactt     9540

acataatgat attcatctct ccattagcaa ttgaatccag gcataaccgg gctcagttac     9600

acagcttgtc tgtgactggg aagcccattt tgtgtcattt ctgcacacct gtccgctgtt     9660

gacaccttat tagaggcact gcattttggt ttcacaattc ttcatctccc ttcccaagga     9720

atgggcaatc tactgaactt ccagatcaat gctttgttgg aaagtgatga atttaagaga     9780

gttttaacat gtcaaatttg aagccaattc agtatcctta tttgttccaa gactcttaac     9840

caatactgtg atataaagtt aggatttggg aaacgtgtag ttaacaactt ggaaacatga     9900

agatattaaa atggcagctg gctaactgtc tcttaagcca ctatgcaatt tctaccaatg     9960

gagagattag ggaagcaaat taagcctcat tcagtaggtc tgctgtctgg tggaacttac    10020

ggaactcatt tcctcctcta tccccagccc ttctcctaac tatggtgata accagggcca    10080

tagaagacct tttctctctt acctttctct gataggatcg tgtccttcag tcaagagctc    10140

atgtgaactc cagactttat attacatctc tgaagttctt gatgtgggga agattgactt    10200

ttattccatt tttatatgaa ggtgttagat atagccatca atttattttt ctacattccc    10260

tctacgctta tgtaattttc tatttttaaa tcttctctta aatatactga gaatctctag    10320

tctccttttc taaaggctga tccaactaca cttgtgggct atttttccaa gctttgtgtg    10380

aaacttgatg acattgggcc agcaaaatgc aaagaagact atagtttcag gcagaaaatc    10440

acgtccaaag aatttggcat ggattaaaca acctctacca cactatagct ctcacatagg    10500

ctgaacattt tcctaaattc tacctgtgca gacactgagg ggctctctac ctttgaaact    10560

atgagaacgt cttaaattaa tatgaatatt tctctccatg tatagtgtga gctgccaatg    10620

cattatctta atacatcaag aaggaaatca gatttcaggc acacattagc aattgtttgt    10680

taatgtcctt ggcaaacgtg tacctgcttt ccttcattgt tctcttcagg ggctttcttc    10740

cactttcctc ttatgaaacg aatgtgtttt tgactgttaa ctgggttcgc tttccagatc    10800

tgtctttccc aaatgaaagg ttagtcccat agaccactgg ctattcaggg aaattactct    10860

ctacctcccc atgacatgga tgataagtgt tgagggatga acactctgga aactcttagc    10920

atggattttg aattccagat ttctttatag gagatgtata aaaaggagtt tatagcatac    10980

aaaaattata ctgctcttcc cagtaaggga ctaaaaggac atttgaaatc tttacatttt    11040

agatgttttt gtgaattata aatatctcct ttttcctcgc ttcatgctaa cttgtctcta    11100

gataaaatct tatttcttca tacattggac cacaaggcat aaagaaggta gctcagcgcc    11160

actgagattg tgttctgcat aatatttgga aggcttccat ttccattgaa aacaaatcca    11220

tgagtgagag ggaaagtcta gtatcaattc ttctgtttgc tcgcaatgac acaaataggt    11280

tttggggatc tacctaaggg ataggtctac tccaaaatta ttaaatttat aattgtgcaa    11340

ttctgtaatt tcccaaggca taagtaatat gaccctactg tcagctagat gtcttatctt    11400

caaagagagt atgcattaat aaaaagaact tccctttaaa gaaccaatct aaaatactaa    11460

aaaggcagaa acttttaaaa ttagaaattg gataattttt aagaatcttt agagaaaaca    11520

ttggtttatc atagtctttt tctttcattg agttttcatt tagactagca tggcaagcag    11580

ggtggccttg gactttgatt taggggatcg tgctttggcc tggaaaataa gcactggcct    11640

gcatgcctag aacctgagtg aaggcagtca acatcctagt atgaatcaga cctagcagaa    11700

atgtaaatta tttcaagtac ttcagggttt agttttctta gtgacaccct ggaccctgga    11760

tgctgctttc taaagtgcac ctgatccatg cagttttatg tcttcatata actggtatct    11820

tgtgagtttg caagcaatgg gatgagcaag aaaaaaagga cgcatggagg agaaaaattt    11880

gaacgaggct agtgcaatgt tttgctgata gattacattg ttagggagct ggtgattttt    11940

tgccatggtc gtatcgtgga cagcttttcc gtggaaattc aaggcatctg tattaggcaa    12000

atgtgagtgc ccttgatctt gtattgatca gtgccaatgt actgggaaag caggtacccc    12060

agtgaaactg gtctgtgctt ggtttaacag ctccaacaat ttcagatcca tggggctgct    12120

tgaccataga ccctgtttac tccatgcctg ttcaaaagtc attttgactt ctagctttgt    12180

ttcactttct tctttcaata cttctgtttc ctcgtccttt tccttcatat tccatggcta    12240

tttctttcct actttacagt ttcccccaga cccagatttt ttcacacctc tgcatcatag    12300

acaactgagt agctcccttg gcccctcctc catcctctca caccctgtgc tccgttcctc    12360

agccgtttgg acagggagct ccgctgtcac caaggagccc atgtgagaca cactgctgtg    12420

actgcctctt gttaatgtca gcatcacctc atcacttaag caaaaaggaa aatccataaa    12480

agagatggaa aatacgtctc tttttatttt attttaagaa gattgggcgg ggtggggggg    12540

gggttcttat tctaggcctt ctcaatttct catagatttt accttaaact aattaaggcc    12600

attctcttga taaatttgta catcagaccg ggtcaccagc tatgatgcag aacgccagat    12660

ttttgaatct caagtaactt tctgtggtgc tggacaaatt gacttaattc tgtgcaggca    12720

aacactttga atcataagga tttttattgc cgctccattc ttactactat tcatgattca    12780

aacatctacc cctgttctga atcaggatgt tgacacttct tggttatttt cagatgaaca    12840

gtaactgcta cactcttgaa agcacttaaa agtgcaagca tgtcctaaat agccatttaa    12900

cctggtaaaa cataggcttt tctgtttaat taagtattag accagtctgt agatataatc    12960

tgaaaagatt gtaggcagta atgaagacag ttggggaaag gagaaggccc tttaaagaca    13020

tgaaacctta cacgctcttg ggatattttt aagcataata agctcattgg attcaggtat    13080

ttttcccttt gcatttttaa aaatacgtat ttctaatttg tttgcatatt taattttgtc    13140

aaagctgaga aatgctcatg agttgaattt ataaatgtca tttgcaacca aatgaagtat    13200

ttatttttaa aaagagagtg aaggaaccaa cactgatttg tacataataa aaatgtgtgt    13260

attatatata tatatttttt cctccttgac agtacttggt cacaatatca agtgtatttt    13320

tgtacataat atatattgat tagaaaaacg tcaattgtct attcaaaaaa ttctatctct    13380

gtgatagatt atatttatcc taatctgttg atacctctgt taatttgttt taagagaatt    13440

atattttttg gaatttacag agaattgcat tcatggcttt caattgtaaa tatgctaagg    13500

gtattttaat aaatcttggt ttcatgtcca aaaaaaaaaa aaaaaa                   13546


<210>  16
<211>  1419
<212>  PRT
<213>  Homo sapiens

<400>  16

Met Glu Gly Thr His Cys Thr Leu Gln Leu His Lys Pro Ile Thr Glu 
1               5                   10                  15      


Leu Cys Tyr Ile Ser Phe Cys Leu Pro Lys Gly Glu Val Arg Gly Phe 
            20                  25                  30          


Ser Tyr Lys Gly Thr Val Thr Leu Asp Arg Ser Asn Lys Gly Phe His 
        35                  40                  45              


Asn Cys Tyr Gln Val Arg Glu Glu Ser Asp Ile Ile Ser Leu Ser Gln 
    50                  55                  60                  


Glu Pro Asp Glu His Pro Gly Asp Ile Phe Phe Lys Gln Thr Pro Thr 
65                  70                  75                  80  


Lys Asp Ile Leu Thr Glu Leu Tyr Lys Leu Thr Thr Glu Arg Glu Arg 
                85                  90                  95      


Leu Leu Thr Asn Leu Leu Ser Ser Asp His Ile Leu Gly Ile Thr Met 
            100                 105                 110         


Gly Asn Gln Glu Gly Lys Leu Gln Glu Leu Ser Val Ser Leu Ala Pro 
        115                 120                 125             


Glu Asp Asp Cys Phe Gln Ser Ala Gly Asp Trp Gln Gly Glu Leu Pro 
    130                 135                 140                 


Val Gly Pro Leu Asn Lys Arg Ser Thr His Gly Asn Lys Lys Pro Arg 
145                 150                 155                 160 


Arg Ser Ser Gly Arg Arg Glu Ser Phe Gly Ala Leu Pro Gln Lys Arg 
                165                 170                 175     


Thr Lys Arg Lys Gly Arg Gly Gly Arg Glu Ser Ala Pro Leu Met Gly 
            180                 185                 190         


Lys Asp Lys Ile Cys Ser Ser His Ser Leu Pro Leu Ser Arg Thr Arg 
        195                 200                 205             


Pro Asn Leu Trp Val Leu Glu Glu Lys Gly Asn Leu Leu Pro Asn Gly 
    210                 215                 220                 


Ala Leu Ala Cys Ser Leu Gln Arg Arg Glu Ser Cys Pro Pro Asp Ile 
225                 230                 235                 240 


Pro Lys Thr Pro Asp Thr Asp Leu Gly Phe Gly Ser Phe Glu Thr Ala 
                245                 250                 255     


Phe Lys Asp Thr Gly Leu Gly Arg Glu Val Leu Pro Pro Asp Cys Ser 
            260                 265                 270         


Ser Thr Glu Ala Gly Gly Asp Gly Ile Arg Arg Pro Pro Ser Gly Leu 
        275                 280                 285             


Glu His Gln Gln Thr Gly Leu Ser Glu Ser His Gln Asp Pro Glu Lys 
    290                 295                 300                 


His Pro Glu Ala Glu Lys Asp Glu Met Glu Lys Pro Ala Lys Arg Thr 
305                 310                 315                 320 


Cys Lys Gln Lys Pro Val Ser Lys Val Val Ala Lys Val Gln Asp Leu 
                325                 330                 335     


Ser Ser Gln Val Gln Arg Val Val Lys Thr His Ser Lys Gly Lys Glu 
            340                 345                 350         


Thr Ile Ala Ile Arg Pro Ala Ala His Ala Glu Phe Val Pro Lys Ala 
        355                 360                 365             


Asp Leu Leu Thr Leu Pro Gly Ala Glu Ala Gly Ala His Gly Ser Arg 
    370                 375                 380                 


Arg Gln Gly Lys Glu Arg Gln Gly Asp Arg Ser Ser Gln Ser Pro Ala 
385                 390                 395                 400 


Gly Glu Thr Ala Ser Ile Ser Ser Val Ser Ala Ser Ala Glu Gly Ala 
                405                 410                 415     


Val Asn Lys Val Pro Leu Lys Val Ile Glu Ser Glu Lys Leu Asp Glu 
            420                 425                 430         


Ala Pro Glu Gly Lys Arg Leu Gly Phe Pro Val His Thr Ser Val Pro 
        435                 440                 445             


His Thr Arg Pro Glu Thr Arg Asn Lys Arg Arg Ala Gly Leu Pro Leu 
    450                 455                 460                 


Gly Gly His Lys Ser Leu Phe Leu Asp Leu Pro His Lys Val Gly Pro 
465                 470                 475                 480 


Asp Ser Ser Gln Pro Arg Gly Asp Lys Lys Lys Pro Ser Pro Pro Ala 
                485                 490                 495     


Pro Ala Ala Leu Gly Lys Val Phe Asn Asn Ser Ala Ser Gln Ser Ser 
            500                 505                 510         


Thr His Lys Gln Thr Ser Pro Val Pro Ser Pro Leu Ser Pro Arg Leu 
        515                 520                 525             


Pro Ser Pro Gln Gln His His Arg Ile Leu Arg Leu Pro Ala Leu Pro 
    530                 535                 540                 


Gly Glu Arg Glu Ala Ala Leu Asn Asp Ser Pro Cys Arg Lys Ser Arg 
545                 550                 555                 560 


Val Phe Ser Gly Cys Val Ser Ala Asp Thr Leu Glu Pro Pro Ser Ser 
                565                 570                 575     


Ala Lys Val Thr Glu Thr Lys Gly Ala Ser Pro Ala Phe Leu Arg Ala 
            580                 585                 590         


Gly Gln Pro Arg Leu Val Pro Gly Glu Thr Leu Glu Lys Ser Leu Gly 
        595                 600                 605             


Pro Gly Lys Thr Thr Ala Glu Pro Gln His Gln Ser Pro Pro Gly Ile 
    610                 615                 620                 


Ser Ser Glu Gly Phe Pro Trp Asp Gly Phe Asn Glu Gln Thr Pro Lys 
625                 630                 635                 640 


Asp Leu Pro Asn Arg Asp Gly Gly Ala Trp Val Leu Gly Tyr Arg Ala 
                645                 650                 655     


Gly Pro Ala Cys Pro Phe Leu Leu His Glu Glu Arg Glu Lys Ser Asn 
            660                 665                 670         


Arg Ser Glu Leu Tyr Leu Asp Leu His Pro Asp His Ser Leu Thr Glu 
        675                 680                 685             


Gln Asp Asp Arg Thr Pro Gly Arg Leu Gln Ala Val Trp Pro Pro Pro 
    690                 695                 700                 


Lys Thr Lys Asp Thr Glu Glu Lys Val Gly Leu Lys Tyr Thr Glu Ala 
705                 710                 715                 720 


Glu Tyr Gln Ala Ala Ile Leu His Leu Lys Arg Glu His Lys Glu Glu 
                725                 730                 735     


Ile Glu Asn Leu Gln Ala Gln Phe Glu Leu Arg Ala Phe His Ile Arg 
            740                 745                 750         


Gly Glu His Ala Met Ile Thr Ala Arg Leu Glu Glu Thr Ile Glu Asn 
        755                 760                 765             


Leu Lys His Glu Leu Glu His Arg Trp Arg Gly Gly Cys Glu Glu Arg 
    770                 775                 780                 


Lys Asp Val Cys Ile Ser Thr Asp Asp Asp Cys Pro Pro Lys Thr Phe 
785                 790                 795                 800 


Arg Asn Val Cys Val Gln Thr Asp Arg Glu Thr Phe Leu Lys Pro Cys 
                805                 810                 815     


Glu Ser Glu Ser Lys Thr Thr Arg Ser Asn Gln Leu Val Pro Lys Lys 
            820                 825                 830         


Leu Asn Ile Ser Ser Leu Ser Gln Leu Ser Pro Pro Asn Asp His Lys 
        835                 840                 845             


Asp Ile His Ala Ala Leu Gln Pro Met Glu Gly Met Ala Ser Asn Gln 
    850                 855                 860                 


Gln Lys Ala Leu Pro Pro Pro Pro Ala Ser Ile Pro Pro Pro Pro Pro 
865                 870                 875                 880 


Leu Pro Ser Gly Leu Gly Ser Leu Ser Pro Ala Pro Pro Met Pro Pro 
                885                 890                 895     


Val Ser Ala Gly Pro Pro Leu Pro Pro Pro Pro Pro Pro Pro Pro Pro 
            900                 905                 910         


Leu Pro Pro Pro Ser Ser Ala Gly Pro Pro Pro Pro Pro Pro Pro Pro 
        915                 920                 925             


Pro Leu Pro Asn Ser Pro Ala Pro Pro Asn Pro Gly Gly Pro Pro Pro 
    930                 935                 940                 


Ala Pro Pro Pro Pro Gly Leu Ala Pro Pro Pro Pro Pro Gly Leu Phe 
945                 950                 955                 960 


Phe Gly Leu Gly Ser Ser Ser Ser Gln Cys Pro Arg Lys Pro Ala Ile 
                965                 970                 975     


Glu Pro Ser Cys Pro Met Lys Pro Leu Tyr Trp Thr Arg Ile Gln Ile 
            980                 985                 990         


Ser Asp Arg Ser Gln Asn Ala Thr  Pro Thr Leu Trp Asp  Ser Leu Glu 
        995                 1000                 1005             


Glu Pro  Asp Ile Arg Asp Pro  Ser Glu Phe Glu Tyr  Leu Phe Ser 
    1010                 1015                 1020             


Lys Asp  Thr Thr Gln Gln Lys  Lys Lys Pro Leu Ser  Glu Thr Tyr 
    1025                 1030                 1035             


Glu Lys  Lys Asn Lys Val Lys  Lys Ile Ile Lys Leu  Leu Asp Gly 
    1040                 1045                 1050             


Lys Arg  Ser Gln Thr Val Gly  Ile Leu Ile Ser Ser  Leu His Leu 
    1055                 1060                 1065             


Glu Met  Lys Asp Ile Gln Gln  Ala Ile Phe Asn Val  Asp Asp Ser 
    1070                 1075                 1080             


Val Val  Asp Leu Glu Thr Leu  Ala Ala Leu Tyr Glu  Asn Arg Ala 
    1085                 1090                 1095             


Gln Glu  Asp Glu Leu Val Lys  Ile Arg Lys Tyr Tyr  Glu Thr Ser 
    1100                 1105                 1110             


Lys Glu  Glu Glu Leu Lys Leu  Leu Asp Lys Pro Glu  Gln Phe Leu 
    1115                 1120                 1125             


His Glu  Leu Ala Gln Ile Pro  Asn Phe Ala Glu Arg  Ala Gln Cys 
    1130                 1135                 1140             


Ile Ile  Phe Arg Ser Val Phe  Ser Glu Gly Ile Thr  Ser Leu His 
    1145                 1150                 1155             


Arg Lys  Val Glu Ile Ile Thr  Arg Ala Ser Lys Asp  Leu Leu His 
    1160                 1165                 1170             


Val Lys  Ser Val Lys Asp Ile  Leu Ala Leu Ile Leu  Ala Phe Gly 
    1175                 1180                 1185             


Asn Tyr  Met Asn Gly Gly Asn  Arg Thr Arg Gly Gln  Ala Asp Gly 
    1190                 1195                 1200             


Tyr Ser  Leu Glu Ile Leu Pro  Lys Leu Lys Asp Val  Lys Ser Arg 
    1205                 1210                 1215             


Asp Asn  Gly Ile Asn Leu Val  Asp Tyr Val Val Lys  Tyr Tyr Leu 
    1220                 1225                 1230             


Arg Tyr  Tyr Asp Gln Glu Ala  Gly Thr Glu Lys Ser  Val Phe Pro 
    1235                 1240                 1245             


Leu Pro  Glu Pro Gln Asp Phe  Phe Leu Ala Ser Gln  Val Lys Phe 
    1250                 1255                 1260             


Glu Asp  Leu Ile Lys Asp Leu  Arg Lys Leu Lys Arg  Gln Leu Glu 
    1265                 1270                 1275             


Ala Ser  Glu Lys Gln Met Val  Val Val Cys Lys Glu  Ser Pro Lys 
    1280                 1285                 1290             


Glu Tyr  Leu Gln Pro Phe Lys  Asp Lys Leu Glu Glu  Phe Phe Gln 
    1295                 1300                 1305             


Lys Ala  Lys Lys Glu His Lys  Met Glu Glu Ser His  Leu Glu Asn 
    1310                 1315                 1320             


Ala Gln  Lys Ser Phe Glu Thr  Thr Val Arg Tyr Phe  Gly Met Lys 
    1325                 1330                 1335             


Pro Lys  Ser Gly Glu Lys Glu  Ile Thr Pro Ser Tyr  Val Phe Met 
    1340                 1345                 1350             


Val Trp  Tyr Glu Phe Cys Ser  Asp Phe Lys Thr Ile  Trp Lys Arg 
    1355                 1360                 1365             


Glu Ser  Lys Asn Ile Ser Lys  Glu Arg Leu Lys Met  Ala Gln Glu 
    1370                 1375                 1380             


Ser Val  Ser Lys Leu Thr Ser  Glu Lys Lys Val Glu  Thr Lys Lys 
    1385                 1390                 1395             


Ile Asn  Pro Thr Ala Ser Leu  Lys Glu Arg Leu Arg  Gln Lys Glu 
    1400                 1405                 1410             


Ala Ser  Val Thr Thr Asn 
    1415                 


<210>  17
<211>  8555
<212>  DNA
<213>  Homo sapiens

<400>  17
gctaaatggt taagagatac ataaatactg cagtagagat gggattttac ctcaaagtgc       60

aaaggtaaat gaaataaagt tttttcaatg gaaggcttgc agctcttgag gacctgccaa      120

atggaagaag gacagagacc tggagcccta tggaaagttc tgacaccatg tgtggaagga      180

catggctttt aacacgtgtg gtgactggag tagctgcagc tgaggacagc caccctttct      240

tcgtctctgc tgagcgaagg ctacacggcc cttcctcctt gcagctgttt caccttctac      300

cttgcgtgga gccaggcttt tgcaccgaat ctgagatgcc attttaaaca gaagactcca      360

tcctcttgaa gatgggaaat tcttacgctg gacagctgaa gacgacacgc tttgaagagg      420

tcttgcacaa ttccatcgag gcatccctgc ggtccaacaa cctggtgccc aggcccatct      480

tttcccagct gtacctggaa gctgagcagc agcttgccgc tctagaaggt ggtagccgag      540

tggacaatga ggaagaggaa gaagagggag aaggagggct ggaaacaaat ggccccccaa      600

accctttcca gctgcaccct ctgcctgaag gatgctgtac cacagacggg ttttgccagg      660

ccgggaagga cctgcgcctt gtctccattt ccaacgagcc catggatgtc cctgcgggct      720

ttctcctcgt gggggtcaag tcccccagcc tgccggacca tctcctggtg tgcgccgttg      780

acaagaggtt cttgccagat gacaatggcc acaatgctct tcttggtttc tctgggaatt      840

gtgttggctg tggaaagaaa ggcttctgtt acttcacgga attctccaat catataaatc      900

tgaaactgac cactcaaccc aagaagcaga aacacttgaa gtattacctg gtccgtaatg      960

cacaagggac tctaaccaaa ggacctttaa tctgttggaa aggctcagag tttagaagcc     1020

ggcagatccc cgccagtact tgttccagtt ccctcttccc agccctggag agcacggctg     1080

ccttccccag cgagcccgtt cctgggacga accccagcat cctgatggga gctcagcagg     1140

caggaccagc ttctgatcac ccctcactaa acgcagcaat gggtccggct gttttcaacg     1200

gcaaagattc cccgaagtgc caacaactgg caaagaataa cctgttggcc ctgccgcgac     1260

catcggcttt aggtatcttg tcaaactccg ggccccccaa aaaacgccac aaagggtggt     1320

ctccagaatc tccatcagct ccagatggtg gctgccccca aggtggtggg aacagagcta     1380

agtatgagag cgcaggcatg tcctgcgtgc cgcaggttgg cttggtggga ccagcttcag     1440

tcacctttcc agtggtggcc tctggagaac cagtgtctgt tcctgacaac ttgctgaaaa     1500

tatgcaaggc caagccagtg atatttaaag gccatgggaa cttcccttac ctctgtggga     1560

acctgaatga cgtcgtggtc agccccctct tgtacacgtg ctaccagaat tcccagtctg     1620

tctcacgggc atacgagcag tacggcgcct ctgccatcca gcccatctcc gaggagatgc     1680

agctcctgct taccgtctac tacctggtcc agctggccgc ggaccaggtg cccttgatgg     1740

aggacctgga gcagatcttc ctgcgctctt ggcgcgagtc gcacctgacc gagatccggc     1800

agtaccagca ggcgccgccg cagcccttcc cgcccgcgcc cagcgccgcg gcacccgtga     1860

cctccgcgca gctgccctgg ctggccagcc tggccgccag ctcctgcaac gacagcgtgc     1920

acgtcatcga gtgtgcttac tccctggccg agggcctctc cgagatgttc cggctgttgg     1980

tcgagggcaa gcttgccaag accaactacg tggtcatcat ctgcgcctgc cgcagcgcgg     2040

ccatcgactc ctgcatcgcc gtcaccggaa aataccaagc ccggattctt tccgagagcc     2100

ttctcactcc tgcggagtac cagaaggaag tcaattacga gctggttacg gggaaggtag     2160

actcgctggg ggccttcttt agcaccctct gtccagaggg tgacattgac attttgctgg     2220

acaaatttca ccaggaaaat caaggccata tttcttcctc actcgctgcc tcttctgtca     2280

ctaaagcagc atccctggat gtcagtggga caccggtgtg cacaagttac aatctggagc     2340

cacacagcat ccggcccttc cagctggcag tagcgcagaa gctcctctcc catgtgtgtt     2400

ccattgcgga ttccagcacc caaaatctgg acctgggatc ctttgagaag gtggactttc     2460

tcatttgcat tcccccctca gaagtgacct accagcagac tctgctccat gtgtggcatt     2520

caggggtttt gctggagctt ggtctgaaga aagagcacat gacgaagcag agggtggaac     2580

agtatgttct gaagctagac acggaggcac agacaaaatt taaggctttt ctgcaaaact     2640

ccttccagaa cccgcataca ctttttgtcc taatccatga ccatgcgcac tgggatcttg     2700

tgagtagcac tgttcataac ctctattctc aaagtgaccc gtcggtggga ttggtggacc     2760

gattgctcaa ctgcagggag gtgaaggagg cccccaacat tgtgacactt cacgtgacct     2820

ccttcccgta tgcactgcag acacagcaca ccctcatcag cccctacaac gagatccact     2880

ggcctgcctc ctgcagtaat ggagtggact tatatcatga aaataagaag tacttcgggc     2940

tgtcggagtt tattgaatcc accctttcag gacacagcct ccccttgctc agatacgata     3000

gctcctttga ggccatggtc actgcattag gaaaaaggtt cccccgcctg cacagcgcgg     3060

tgatcaggac ctttgttctc gtgcagcact acgcggccgc cctgatggcc gtaagcggcc     3120

tcccgcagat gaagaactac acgtcggtgg agacgctgga gatcacgcag aacctcctca     3180

actccccgaa gcagtgcccc tgcggccacg ggctcatggt cctgctgcgg gtgccctgtt     3240

cgcccctggc ggtggtggcc tatgagcggc tggcccacgt gcgggcccgg ctggcgctgg     3300

aggagcactt tgagatcatc ctgggcagtc ccagctcagg cgtcaccgtg gggaagcact     3360

tcgtaaagca gctcaggatg tggcagaaaa ttgaggatgt ggagtggaga ccccagactt     3420

acttggagct ggagggtctg ccttgcatcc tgatcttcag tgggatggac ccgcatgggg     3480

agtccttgcc gaggtctttg aggtactgtg acctgcgatt gataaactcc tcctgcttgg     3540

tgagaacagc cttggagcag gagctgggcc tggctgccta ctttgtgagc aacgaggttc     3600

ccttggagaa gggggctagg aacgaggcct tggagagtga tgctgagaag ctgagcagca     3660

cagacaacga ggatgaggag ctggggacag aaggctctac ctcggagaag agaagcccca     3720

tgaaaaggga gaggtcccgc tcccacgact cagcatcctc atccctctcc tccaaggctt     3780

ccggttcagc gctcggtggc gagtcctcgg ctcagcccac agcactcccc cagggagagc     3840

atgccaggtc gccccagccc cgtggccccg cagaggaggg cagagcccct ggtgagaaac     3900

agaggccccg ggcaagtcag gggccaccct cggccatcag caggcacagt cccgggccga     3960

cgccccagcc cgactgtagc ctcaggaccg gccagaggag cgtccaggtg tcggtcacct     4020

cgtcgtgctc ccagctgtcc tcctcctcgg gctcatcctc ctcatccgtg gcgcccgctg     4080

ccggcacgtg ggtcctgcag gcctcccagt gctccttgac caaggcctgc cgccagccac     4140

ccattgtctt cttgcccaag ctcgtgtacg acatggttgt gtccactgac agcagtggcc     4200

tgcccaaggc cgcctccctc ctgccctccc cctcggtcat gtgggccagc tctttccgcc     4260

ccctgctcag caagaccatg acatccaccg agcagtccct ctactaccgg cagtggacgg     4320

tgccccggcc cagccacatg gactacggca accgggccga gggccgcgtg gacggcttcc     4380

acccccgcag gctgctgctc agcggccccc ctcagatcgg gaagacaggt gcctacctgc     4440

agttcctcag tgtcctgtcc aggatgcttg ttcggctcac agaagtggat gtctatgacg     4500

aggaggagat caatatcaac ctcagagaag aatctgactg gcattatctc cagcttagcg     4560

acccctggcc agacctggag ctgttcaaga agttgccctt tgactacatc attcacgacc     4620

cgaagtatga agatgccagc ctgatttgtt cgcactatca gggtataaag agtgaagaca     4680

gagggatgtc ccggaagccg gaggaccttt atgtgcggcg tcagacggca cggatgagac     4740

tgtccaagta cgcagcgtac aacacttacc accactgtga gcagtgccac cagtacatgg     4800

gcttccaccc ccgctaccag ctgtatgagt ccaccctgca cgcctttgcc ttctcttact     4860

ccatgctagg agaggagatc cagctgcact tcatcatccc caagtccaag gagcaccact     4920

ttgtcttcag ccaacctgga ggccagctgg agagcatgcg actacccctc gtgacagaca     4980

agagccatga atatataaaa agtccgacat tcactccaac caccggccgt cacgaacatg     5040

ggctctttaa tctgtaccac gcaatggacg gtgccagcca tttgcacgtg ctggttgtca     5100

aggaatacga gatggcaatt tataagaaat attggcccaa ccacatcatg ctggtgctcc     5160

ccagtatctt caacagtgct ggagttggtg ctgctcattt cctcatcaag gagctgtcct     5220

accataacct ggagctcgag cggaaccggc aggaggagct gggaatcaag ccgcaggaca     5280

tctggccttt cattgtgatc tctgatgact cctgcgtgat gtggaacgtg gtggatgtca     5340

actctgctgg ggagagaagc agggagttct cctggtcgga aaggaacgtg tctttgaagc     5400

acatcatgca gcacatcgag gcggcccccg acatcatgca ctacgccctg ctgggcctgc     5460

ggaagtggtc cagcaagacc cgggccagcg aggtgcaaga gcccttctcc cgctgccacg     5520

tgcacaactt catcatcctg aacgtggacc tgacccagaa cgtgcagtac aaccagaacc     5580

ggttcctgtg tgacgatgta gacttcaacc tgcgggtgca cagcgccggc ctcctgctct     5640

gccggttcaa ccgcttcagc gtgatgaaga agcagatcgt ggtgggcggc cacaggtcct     5700

tccacatcac atccaaggtg tctgataact ctgccgcggt cgtgccggcc cagtacatct     5760

gtgccccgga cagcaagcac acgttcctcg cagcgcccgc ccagctcctg ctggagaagt     5820

tcctgcagca ccacagccac ctcttcttcc cgctgtccct gaagaaccat gaccacccag     5880

tgctgtctgt cgactgttac ctgaacctgg gatctcagat ttctgtttgc tatgtgagct     5940

ccaggcccca ctctttaaac atcagctgct cggacttgct gttcagtggg ctgctgctgt     6000

acctctgtga ctcttttgtg ggagctagct ttttgaaaaa gtttcatttt ctgaaaggtg     6060

cgacgttgtg tgtcatctgt caggaccgga gctcactgcg ccagacggtc gtccgcctgg     6120

agctcgagga cgagtggcag ttccggctgc gcgatgagtt ccagaccgcc aatgccaggg     6180

aagaccggcc gctctttttt ctgacgggac gacacatctg aggaagacag cggcgagttt     6240

tctgaagaga tgagtgctca gagccctcat gctgttgagg ctaaagggag gcctggaacg     6300

gtggggcgtt tgactggaat ggaccccagg gactgtccag gtgcagcccc tcctagtaca     6360

catgggcccc cgaggccgtg gtcctgggag ccaggaagac tccgcagtgg gtgagaatga     6420

aaacttgaga ctcccaagtt ctgggccagc ccattgctct gggctgtttt aaagcccatt     6480

tcacgaggaa caaagattta cttcctgtcc tgccattcgt gtgcttccat ggacaaacct     6540

gatttttttc tcttagttct aaagaatctt gggttatttt gtagcggtgc cagtatttca     6600

gtagatggga tttcagccaa gtaggttccc ctgtaacctc ctacaaagca atattccaaa     6660

ggaacatttt aactgtaaag gctggagaca agaaaaaata agtagatcgt tttaataaca     6720

attatttaat tgcctataag tttgctgttt cagaggctag cccaaaggca tcaaatttaa     6780

taaagttaaa caaattgatt tacttcagag caaatatgat cctattaaaa taatataggg     6840

taaataccct acctcttaga aagggcaaaa atgcaaagaa gctttcttta aaactaaaag     6900

ggttttttgg ggggggagtt ggcggggagg aaataaggct aacagaggtt gacctaaaat     6960

tagccttaca aaggagaaag gaccacattg cttacttgaa acagacaatg aaaacaacca     7020

aagtgatata taaaatagtt gatgagaact agacttatga ctgtagttta ctagagttta     7080

gttttcagtt gctgaagtag ctcattttct cttactaatg tttggttcct cagggaagaa     7140

tctcacttga ctagagagga ggtgggaaca gaagagagaa ggaggcaggg agatgtattt     7200

cttagggctc accccttcac agactgacag aatggttttg ttttgttttg ttttgttttg     7260

ttttgttttt gagatggact ctagctctgt cacccaggct ggagtgcagt ggtgcgatct     7320

cggctcactg caagctccgc ctcccgggtt ctcaccattc tcctgcctca gcctcccgag     7380

tagctgggac tacaggcgcc caccaccacg cccggctaat tttttgtatt ttttagtaga     7440

gacggggttt caccatgtta gccaggatgg tctcgatctc ctgacctcgt gatccgcccg     7500

cctcggcctc ccaaagtgct gggattacag gcgtgagcca ccgtgcctgc cccagaatgg     7560

tttttaaagc cacagttgag aggccaccca ttgcccggcg cctggacagt gatcatcttg     7620

ttcatcttgt tcagtccttt cttgtgtgat tggaattatt catccccttt gaaagatgag     7680

aaggttgaga tgcaaagagt ctacctttcc aagttctcac tgctggaaag agctagaagc     7740

acagttcaaa gttctggctt ctggactctg cagtccaggt ctcccttctc ccacttgcct     7800

accctcaatg ccacactgtt tttgaagtgg cccataactt gaaggaaaag tttaaagaca     7860

gttcaattta atcatcagaa tgcattcttt tttttttcgg agacggagtt tcactcttgc     7920

tgcccaggct ggagtgcaat ggtgcaatga cctcggctca ctgcaacctc tgcctcctgg     7980

gttcaagtga ttctccagcc tcagcctccc gagtagctgg gattatgggc gcccaccacc     8040

atgcccagct aatttttgta tttttttttt ttagtagaga tggggtttcg ccaggttggc     8100

caggctggtc ttgtgaactc ctggcctcag gtgatctgcc cacctcatcc tccaaaagtg     8160

ctgggattac aggcatgagc cactgcgcct ggcctcagaa tgcattctta cacatctatc     8220

ctagacattt ataagcactc taatggataa caatccaaga ataaatgatt gtaaaagatg     8280

atgccgaaga gttgatgtca atcttttttt cctaagaaaa aaagtccgcg agtattaaat     8340

atttagatca atgtttataa aatgattact ttgtatatct cattattcct attttggaat     8400

aaaaactgac cttctttaat catatacttg tcttttgtaa atagcagctt ttgtgtcatt     8460

ctccccactt tattagttaa tttaaattgg aaaaaaccct caaactaata ttcttgtctg     8520

ttccagtctt ataaataaaa cttataatgc atgta                                8555


<210>  18
<211>  1949
<212>  PRT
<213>  Homo sapiens

<400>  18

Met Gly Asn Ser Tyr Ala Gly Gln Leu Lys Thr Thr Arg Phe Glu Glu 
1               5                   10                  15      


Val Leu His Asn Ser Ile Glu Ala Ser Leu Arg Ser Asn Asn Leu Val 
            20                  25                  30          


Pro Arg Pro Ile Phe Ser Gln Leu Tyr Leu Glu Ala Glu Gln Gln Leu 
        35                  40                  45              


Ala Ala Leu Glu Gly Gly Ser Arg Val Asp Asn Glu Glu Glu Glu Glu 
    50                  55                  60                  


Glu Gly Glu Gly Gly Leu Glu Thr Asn Gly Pro Pro Asn Pro Phe Gln 
65                  70                  75                  80  


Leu His Pro Leu Pro Glu Gly Cys Cys Thr Thr Asp Gly Phe Cys Gln 
                85                  90                  95      


Ala Gly Lys Asp Leu Arg Leu Val Ser Ile Ser Asn Glu Pro Met Asp 
            100                 105                 110         


Val Pro Ala Gly Phe Leu Leu Val Gly Val Lys Ser Pro Ser Leu Pro 
        115                 120                 125             


Asp His Leu Leu Val Cys Ala Val Asp Lys Arg Phe Leu Pro Asp Asp 
    130                 135                 140                 


Asn Gly His Asn Ala Leu Leu Gly Phe Ser Gly Asn Cys Val Gly Cys 
145                 150                 155                 160 


Gly Lys Lys Gly Phe Cys Tyr Phe Thr Glu Phe Ser Asn His Ile Asn 
                165                 170                 175     


Leu Lys Leu Thr Thr Gln Pro Lys Lys Gln Lys His Leu Lys Tyr Tyr 
            180                 185                 190         


Leu Val Arg Asn Ala Gln Gly Thr Leu Thr Lys Gly Pro Leu Ile Cys 
        195                 200                 205             


Trp Lys Gly Ser Glu Phe Arg Ser Arg Gln Ile Pro Ala Ser Thr Cys 
    210                 215                 220                 


Ser Ser Ser Leu Phe Pro Ala Leu Glu Ser Thr Ala Ala Phe Pro Ser 
225                 230                 235                 240 


Glu Pro Val Pro Gly Thr Asn Pro Ser Ile Leu Met Gly Ala Gln Gln 
                245                 250                 255     


Ala Gly Pro Ala Ser Asp His Pro Ser Leu Asn Ala Ala Met Gly Pro 
            260                 265                 270         


Ala Val Phe Asn Gly Lys Asp Ser Pro Lys Cys Gln Gln Leu Ala Lys 
        275                 280                 285             


Asn Asn Leu Leu Ala Leu Pro Arg Pro Ser Ala Leu Gly Ile Leu Ser 
    290                 295                 300                 


Asn Ser Gly Pro Pro Lys Lys Arg His Lys Gly Trp Ser Pro Glu Ser 
305                 310                 315                 320 


Pro Ser Ala Pro Asp Gly Gly Cys Pro Gln Gly Gly Gly Asn Arg Ala 
                325                 330                 335     


Lys Tyr Glu Ser Ala Gly Met Ser Cys Val Pro Gln Val Gly Leu Val 
            340                 345                 350         


Gly Pro Ala Ser Val Thr Phe Pro Val Val Ala Ser Gly Glu Pro Val 
        355                 360                 365             


Ser Val Pro Asp Asn Leu Leu Lys Ile Cys Lys Ala Lys Pro Val Ile 
    370                 375                 380                 


Phe Lys Gly His Gly Asn Phe Pro Tyr Leu Cys Gly Asn Leu Asn Asp 
385                 390                 395                 400 


Val Val Val Ser Pro Leu Leu Tyr Thr Cys Tyr Gln Asn Ser Gln Ser 
                405                 410                 415     


Val Ser Arg Ala Tyr Glu Gln Tyr Gly Ala Ser Ala Ile Gln Pro Ile 
            420                 425                 430         


Ser Glu Glu Met Gln Leu Leu Leu Thr Val Tyr Tyr Leu Val Gln Leu 
        435                 440                 445             


Ala Ala Asp Gln Val Pro Leu Met Glu Asp Leu Glu Gln Ile Phe Leu 
    450                 455                 460                 


Arg Ser Trp Arg Glu Ser His Leu Thr Glu Ile Arg Gln Tyr Gln Gln 
465                 470                 475                 480 


Ala Pro Pro Gln Pro Phe Pro Pro Ala Pro Ser Ala Ala Ala Pro Val 
                485                 490                 495     


Thr Ser Ala Gln Leu Pro Trp Leu Ala Ser Leu Ala Ala Ser Ser Cys 
            500                 505                 510         


Asn Asp Ser Val His Val Ile Glu Cys Ala Tyr Ser Leu Ala Glu Gly 
        515                 520                 525             


Leu Ser Glu Met Phe Arg Leu Leu Val Glu Gly Lys Leu Ala Lys Thr 
    530                 535                 540                 


Asn Tyr Val Val Ile Ile Cys Ala Cys Arg Ser Ala Ala Ile Asp Ser 
545                 550                 555                 560 


Cys Ile Ala Val Thr Gly Lys Tyr Gln Ala Arg Ile Leu Ser Glu Ser 
                565                 570                 575     


Leu Leu Thr Pro Ala Glu Tyr Gln Lys Glu Val Asn Tyr Glu Leu Val 
            580                 585                 590         


Thr Gly Lys Val Asp Ser Leu Gly Ala Phe Phe Ser Thr Leu Cys Pro 
        595                 600                 605             


Glu Gly Asp Ile Asp Ile Leu Leu Asp Lys Phe His Gln Glu Asn Gln 
    610                 615                 620                 


Gly His Ile Ser Ser Ser Leu Ala Ala Ser Ser Val Thr Lys Ala Ala 
625                 630                 635                 640 


Ser Leu Asp Val Ser Gly Thr Pro Val Cys Thr Ser Tyr Asn Leu Glu 
                645                 650                 655     


Pro His Ser Ile Arg Pro Phe Gln Leu Ala Val Ala Gln Lys Leu Leu 
            660                 665                 670         


Ser His Val Cys Ser Ile Ala Asp Ser Ser Thr Gln Asn Leu Asp Leu 
        675                 680                 685             


Gly Ser Phe Glu Lys Val Asp Phe Leu Ile Cys Ile Pro Pro Ser Glu 
    690                 695                 700                 


Val Thr Tyr Gln Gln Thr Leu Leu His Val Trp His Ser Gly Val Leu 
705                 710                 715                 720 


Leu Glu Leu Gly Leu Lys Lys Glu His Met Thr Lys Gln Arg Val Glu 
                725                 730                 735     


Gln Tyr Val Leu Lys Leu Asp Thr Glu Ala Gln Thr Lys Phe Lys Ala 
            740                 745                 750         


Phe Leu Gln Asn Ser Phe Gln Asn Pro His Thr Leu Phe Val Leu Ile 
        755                 760                 765             


His Asp His Ala His Trp Asp Leu Val Ser Ser Thr Val His Asn Leu 
    770                 775                 780                 


Tyr Ser Gln Ser Asp Pro Ser Val Gly Leu Val Asp Arg Leu Leu Asn 
785                 790                 795                 800 


Cys Arg Glu Val Lys Glu Ala Pro Asn Ile Val Thr Leu His Val Thr 
                805                 810                 815     


Ser Phe Pro Tyr Ala Leu Gln Thr Gln His Thr Leu Ile Ser Pro Tyr 
            820                 825                 830         


Asn Glu Ile His Trp Pro Ala Ser Cys Ser Asn Gly Val Asp Leu Tyr 
        835                 840                 845             


His Glu Asn Lys Lys Tyr Phe Gly Leu Ser Glu Phe Ile Glu Ser Thr 
    850                 855                 860                 


Leu Ser Gly His Ser Leu Pro Leu Leu Arg Tyr Asp Ser Ser Phe Glu 
865                 870                 875                 880 


Ala Met Val Thr Ala Leu Gly Lys Arg Phe Pro Arg Leu His Ser Ala 
                885                 890                 895     


Val Ile Arg Thr Phe Val Leu Val Gln His Tyr Ala Ala Ala Leu Met 
            900                 905                 910         


Ala Val Ser Gly Leu Pro Gln Met Lys Asn Tyr Thr Ser Val Glu Thr 
        915                 920                 925             


Leu Glu Ile Thr Gln Asn Leu Leu Asn Ser Pro Lys Gln Cys Pro Cys 
    930                 935                 940                 


Gly His Gly Leu Met Val Leu Leu Arg Val Pro Cys Ser Pro Leu Ala 
945                 950                 955                 960 


Val Val Ala Tyr Glu Arg Leu Ala His Val Arg Ala Arg Leu Ala Leu 
                965                 970                 975     


Glu Glu His Phe Glu Ile Ile Leu Gly Ser Pro Ser Ser Gly Val Thr 
            980                 985                 990         


Val Gly Lys His Phe Val Lys Gln  Leu Arg Met Trp Gln  Lys Ile Glu 
        995                 1000                 1005             


Asp Val  Glu Trp Arg Pro Gln  Thr Tyr Leu Glu Leu  Glu Gly Leu 
    1010                 1015                 1020             


Pro Cys  Ile Leu Ile Phe Ser  Gly Met Asp Pro His  Gly Glu Ser 
    1025                 1030                 1035             


Leu Pro  Arg Ser Leu Arg Tyr  Cys Asp Leu Arg Leu  Ile Asn Ser 
    1040                 1045                 1050             


Ser Cys  Leu Val Arg Thr Ala  Leu Glu Gln Glu Leu  Gly Leu Ala 
    1055                 1060                 1065             


Ala Tyr  Phe Val Ser Asn Glu  Val Pro Leu Glu Lys  Gly Ala Arg 
    1070                 1075                 1080             


Asn Glu  Ala Leu Glu Ser Asp  Ala Glu Lys Leu Ser  Ser Thr Asp 
    1085                 1090                 1095             


Asn Glu  Asp Glu Glu Leu Gly  Thr Glu Gly Ser Thr  Ser Glu Lys 
    1100                 1105                 1110             


Arg Ser  Pro Met Lys Arg Glu  Arg Ser Arg Ser His  Asp Ser Ala 
    1115                 1120                 1125             


Ser Ser  Ser Leu Ser Ser Lys  Ala Ser Gly Ser Ala  Leu Gly Gly 
    1130                 1135                 1140             


Glu Ser  Ser Ala Gln Pro Thr  Ala Leu Pro Gln Gly  Glu His Ala 
    1145                 1150                 1155             


Arg Ser  Pro Gln Pro Arg Gly  Pro Ala Glu Glu Gly  Arg Ala Pro 
    1160                 1165                 1170             


Gly Glu  Lys Gln Arg Pro Arg  Ala Ser Gln Gly Pro  Pro Ser Ala 
    1175                 1180                 1185             


Ile Ser  Arg His Ser Pro Gly  Pro Thr Pro Gln Pro  Asp Cys Ser 
    1190                 1195                 1200             


Leu Arg  Thr Gly Gln Arg Ser  Val Gln Val Ser Val  Thr Ser Ser 
    1205                 1210                 1215             


Cys Ser  Gln Leu Ser Ser Ser  Ser Gly Ser Ser Ser  Ser Ser Val 
    1220                 1225                 1230             


Ala Pro  Ala Ala Gly Thr Trp  Val Leu Gln Ala Ser  Gln Cys Ser 
    1235                 1240                 1245             


Leu Thr  Lys Ala Cys Arg Gln  Pro Pro Ile Val Phe  Leu Pro Lys 
    1250                 1255                 1260             


Leu Val  Tyr Asp Met Val Val  Ser Thr Asp Ser Ser  Gly Leu Pro 
    1265                 1270                 1275             


Lys Ala  Ala Ser Leu Leu Pro  Ser Pro Ser Val Met  Trp Ala Ser 
    1280                 1285                 1290             


Ser Phe  Arg Pro Leu Leu Ser  Lys Thr Met Thr Ser  Thr Glu Gln 
    1295                 1300                 1305             


Ser Leu  Tyr Tyr Arg Gln Trp  Thr Val Pro Arg Pro  Ser His Met 
    1310                 1315                 1320             


Asp Tyr  Gly Asn Arg Ala Glu  Gly Arg Val Asp Gly  Phe His Pro 
    1325                 1330                 1335             


Arg Arg  Leu Leu Leu Ser Gly  Pro Pro Gln Ile Gly  Lys Thr Gly 
    1340                 1345                 1350             


Ala Tyr  Leu Gln Phe Leu Ser  Val Leu Ser Arg Met  Leu Val Arg 
    1355                 1360                 1365             


Leu Thr  Glu Val Asp Val Tyr  Asp Glu Glu Glu Ile  Asn Ile Asn 
    1370                 1375                 1380             


Leu Arg  Glu Glu Ser Asp Trp  His Tyr Leu Gln Leu  Ser Asp Pro 
    1385                 1390                 1395             


Trp Pro  Asp Leu Glu Leu Phe  Lys Lys Leu Pro Phe  Asp Tyr Ile 
    1400                 1405                 1410             


Ile His  Asp Pro Lys Tyr Glu  Asp Ala Ser Leu Ile  Cys Ser His 
    1415                 1420                 1425             


Tyr Gln  Gly Ile Lys Ser Glu  Asp Arg Gly Met Ser  Arg Lys Pro 
    1430                 1435                 1440             


Glu Asp  Leu Tyr Val Arg Arg  Gln Thr Ala Arg Met  Arg Leu Ser 
    1445                 1450                 1455             


Lys Tyr  Ala Ala Tyr Asn Thr  Tyr His His Cys Glu  Gln Cys His 
    1460                 1465                 1470             


Gln Tyr  Met Gly Phe His Pro  Arg Tyr Gln Leu Tyr  Glu Ser Thr 
    1475                 1480                 1485             


Leu His  Ala Phe Ala Phe Ser  Tyr Ser Met Leu Gly  Glu Glu Ile 
    1490                 1495                 1500             


Gln Leu  His Phe Ile Ile Pro  Lys Ser Lys Glu His  His Phe Val 
    1505                 1510                 1515             


Phe Ser  Gln Pro Gly Gly Gln  Leu Glu Ser Met Arg  Leu Pro Leu 
    1520                 1525                 1530             


Val Thr  Asp Lys Ser His Glu  Tyr Ile Lys Ser Pro  Thr Phe Thr 
    1535                 1540                 1545             


Pro Thr  Thr Gly Arg His Glu  His Gly Leu Phe Asn  Leu Tyr His 
    1550                 1555                 1560             


Ala Met  Asp Gly Ala Ser His  Leu His Val Leu Val  Val Lys Glu 
    1565                 1570                 1575             


Tyr Glu  Met Ala Ile Tyr Lys  Lys Tyr Trp Pro Asn  His Ile Met 
    1580                 1585                 1590             


Leu Val  Leu Pro Ser Ile Phe  Asn Ser Ala Gly Val  Gly Ala Ala 
    1595                 1600                 1605             


His Phe  Leu Ile Lys Glu Leu  Ser Tyr His Asn Leu  Glu Leu Glu 
    1610                 1615                 1620             


Arg Asn  Arg Gln Glu Glu Leu  Gly Ile Lys Pro Gln  Asp Ile Trp 
    1625                 1630                 1635             


Pro Phe  Ile Val Ile Ser Asp  Asp Ser Cys Val Met  Trp Asn Val 
    1640                 1645                 1650             


Val Asp  Val Asn Ser Ala Gly  Glu Arg Ser Arg Glu  Phe Ser Trp 
    1655                 1660                 1665             


Ser Glu  Arg Asn Val Ser Leu  Lys His Ile Met Gln  His Ile Glu 
    1670                 1675                 1680             


Ala Ala  Pro Asp Ile Met His  Tyr Ala Leu Leu Gly  Leu Arg Lys 
    1685                 1690                 1695             


Trp Ser  Ser Lys Thr Arg Ala  Ser Glu Val Gln Glu  Pro Phe Ser 
    1700                 1705                 1710             


Arg Cys  His Val His Asn Phe  Ile Ile Leu Asn Val  Asp Leu Thr 
    1715                 1720                 1725             


Gln Asn  Val Gln Tyr Asn Gln  Asn Arg Phe Leu Cys  Asp Asp Val 
    1730                 1735                 1740             


Asp Phe  Asn Leu Arg Val His  Ser Ala Gly Leu Leu  Leu Cys Arg 
    1745                 1750                 1755             


Phe Asn  Arg Phe Ser Val Met  Lys Lys Gln Ile Val  Val Gly Gly 
    1760                 1765                 1770             


His Arg  Ser Phe His Ile Thr  Ser Lys Val Ser Asp  Asn Ser Ala 
    1775                 1780                 1785             


Ala Val  Val Pro Ala Gln Tyr  Ile Cys Ala Pro Asp  Ser Lys His 
    1790                 1795                 1800             


Thr Phe  Leu Ala Ala Pro Ala  Gln Leu Leu Leu Glu  Lys Phe Leu 
    1805                 1810                 1815             


Gln His  His Ser His Leu Phe  Phe Pro Leu Ser Leu  Lys Asn His 
    1820                 1825                 1830             


Asp His  Pro Val Leu Ser Val  Asp Cys Tyr Leu Asn  Leu Gly Ser 
    1835                 1840                 1845             


Gln Ile  Ser Val Cys Tyr Val  Ser Ser Arg Pro His  Ser Leu Asn 
    1850                 1855                 1860             


Ile Ser  Cys Ser Asp Leu Leu  Phe Ser Gly Leu Leu  Leu Tyr Leu 
    1865                 1870                 1875             


Cys Asp  Ser Phe Val Gly Ala  Ser Phe Leu Lys Lys  Phe His Phe 
    1880                 1885                 1890             


Leu Lys  Gly Ala Thr Leu Cys  Val Ile Cys Gln Asp  Arg Ser Ser 
    1895                 1900                 1905             


Leu Arg  Gln Thr Val Val Arg  Leu Glu Leu Glu Asp  Glu Trp Gln 
    1910                 1915                 1920             


Phe Arg  Leu Arg Asp Glu Phe  Gln Thr Ala Asn Ala  Arg Glu Asp 
    1925                 1930                 1935             


Arg Pro  Leu Phe Phe Leu Thr  Gly Arg His Ile 
    1940                 1945                 


<210>  19
<211>  2246
<212>  DNA
<213>  Homo sapiens

<400>  19
aaagtccggg ggagccggtc ccgggcagcc gctcagcccc ctgcccctcg ccgcccgccg       60

cctgcctggg ccgggccgag gatgcggcgc agcgcctcgg cggccaggct tgctcccctc      120

cggcacgcct gctaacttcc cccgctacgt ccccgttcgc ccgccgggcc gccccgtctc      180

cccgcgccct ccgggtcggg tcctccagga gcgccaggcg ctgccgccgt gtgccctccg      240

ccgctcgccc gcgcgcccgc gctccccgcc tgcgcccagc gccccgcgcc cgcgcccagt      300

cctcgggcgg tcatgctgcc cctctgcctc gtggccgccc tgctgctggc cgccgggccc      360

gggccgagcc tgggcgacga agccatccac tgcccgccct gctccgagga gaagctggcg      420

cgctgccgcc cccccgtggg ctgcgaggag ctggtgcgag agccgggctg cggctgttgc      480

gccacttgcg ccctgggctt ggggatgccc tgcggggtgt acaccccccg ttgcggctcg      540

ggcctgcgct gctacccgcc ccgaggggtg gagaagcccc tgcacacact gatgcacggg      600

caaggcgtgt gcatggagct ggcggagatc gaggccatcc aggaaagcct gcagccctct      660

gacaaggacg agggtgacca ccccaacaac agcttcagcc cctgtagcgc ccatgaccgc      720

aggtgcctgc agaagcactt cgccaaaatt cgagaccgga gcaccagtgg gggcaagatg      780

aaggtcaatg gggcgccccg ggaggatgcc cggcctgtgc cccagggctc ctgccagagc      840

gagctgcacc gggcgctgga gcggctggcc gcttcacaga gccgcaccca cgaggacctc      900

tacatcatcc ccatccccaa ctgcgaccgc aacggcaact tccaccccaa gcagtgtcac      960

ccagctctgg atgggcagcg tggcaagtgc tggtgtgtgg accggaagac gggggtgaag     1020

cttccggggg gcctggagcc aaagggggag ctggactgcc accagctggc tgacagcttt     1080

cgagagtgag gcctgccagc aggccaggga ctcagcgtcc cctgctactc ctgtgctctg     1140

gaggctgcag agctgaccca gagtggagtc tgagtctgag tcctgtctct gcctgcggcc     1200

cagaagtttc cctcaaatgc gcgtgtgcac gtgtgcgtgt gcgtgcgtgt gtgtgtgttt     1260

gtgagcatgg gtgtgccctt ggggtaagcc agagcctggg gtgttctctt tggtgttaca     1320

cagcccaaga ggactgagac tggcacttag cccaagaggt ctgagccctg gtgtgtttcc     1380

agatcgatcc tggattcact cactcactca ttccttcact catccagcca cctaaaaaca     1440

tttactgacc atgtactacg tgccagctct agttttcagc cttgggaggt tttattctga     1500

cttcctctga ttttggcatg tggagacact cctataagga gagttcaagc ctgtgggagt     1560

agaaaaatct cattcccaga gtcagaggag aagagacatg taccttgacc atcgtccttc     1620

ctctcaagct agccagaggg tgggagccta aggaagcgtg gggtagcaga tggagtaatg     1680

gtcacgaggt ccagacccac tcccaaagct cagacttgcc aggctccctt tctcttcttc     1740

cccaggtcct tcctttaggt ctggttgttg caccatctgc ttggttggct ggcagctgag     1800

agccctgctg tgggagagcg aagggggtca aaggaagact tgaagcacag agggctaggg     1860

aggtggggta catttctctg agcagtcagg gtgggaagaa agaatgcaag agtggactga     1920

atgtgcctaa tggagaagac ccacgtgcta ggggatgagg ggcttcctgg gtcctgttcc     1980

ctaccccatt tgtggtcaca gccatgaagt caccgggatg aacctatcct tccagtggct     2040

cgctccctgt agctctgcct ccctctccat atctccttcc cctacacctc cctccccaca     2100

cctccctact cccctgggca tcttctggct tgactggatg gaaggagact taggaaccta     2160

ccagttggcc atgatgtctt ttcttctttt tctttttttt aacaaaacag aacaaaacca     2220

aaaaatgtcc agatgaaaaa aaaaaa                                          2246


<210>  20
<211>  258
<212>  PRT
<213>  Homo sapiens

<400>  20

Met Leu Pro Leu Cys Leu Val Ala Ala Leu Leu Leu Ala Ala Gly Pro 
1               5                   10                  15      


Gly Pro Ser Leu Gly Asp Glu Ala Ile His Cys Pro Pro Cys Ser Glu 
            20                  25                  30          


Glu Lys Leu Ala Arg Cys Arg Pro Pro Val Gly Cys Glu Glu Leu Val 
        35                  40                  45              


Arg Glu Pro Gly Cys Gly Cys Cys Ala Thr Cys Ala Leu Gly Leu Gly 
    50                  55                  60                  


Met Pro Cys Gly Val Tyr Thr Pro Arg Cys Gly Ser Gly Leu Arg Cys 
65                  70                  75                  80  


Tyr Pro Pro Arg Gly Val Glu Lys Pro Leu His Thr Leu Met His Gly 
                85                  90                  95      


Gln Gly Val Cys Met Glu Leu Ala Glu Ile Glu Ala Ile Gln Glu Ser 
            100                 105                 110         


Leu Gln Pro Ser Asp Lys Asp Glu Gly Asp His Pro Asn Asn Ser Phe 
        115                 120                 125             


Ser Pro Cys Ser Ala His Asp Arg Arg Cys Leu Gln Lys His Phe Ala 
    130                 135                 140                 


Lys Ile Arg Asp Arg Ser Thr Ser Gly Gly Lys Met Lys Val Asn Gly 
145                 150                 155                 160 


Ala Pro Arg Glu Asp Ala Arg Pro Val Pro Gln Gly Ser Cys Gln Ser 
                165                 170                 175     


Glu Leu His Arg Ala Leu Glu Arg Leu Ala Ala Ser Gln Ser Arg Thr 
            180                 185                 190         


His Glu Asp Leu Tyr Ile Ile Pro Ile Pro Asn Cys Asp Arg Asn Gly 
        195                 200                 205             


Asn Phe His Pro Lys Gln Cys His Pro Ala Leu Asp Gly Gln Arg Gly 
    210                 215                 220                 


Lys Cys Trp Cys Val Asp Arg Lys Thr Gly Val Lys Leu Pro Gly Gly 
225                 230                 235                 240 


Leu Glu Pro Lys Gly Glu Leu Asp Cys His Gln Leu Ala Asp Ser Phe 
                245                 250                 255     


Arg Glu 
        


<210>  21
<211>  5016
<212>  DNA
<213>  Homo sapiens

<400>  21
acaggaggag ccgctcgctg gcggctgatc cagcgtctcc gtgacaggca ccctgctccg       60

ccgccaccgc caccgccacc gccaccgtcg ccttttcttc ttcgtcccgg gcggtgcgtt      120

ccactgctct ggggccggcg ccgcgcccag tcccgcttcg ggccgcaagc cccaccgctc      180

ccctccccgg gcaggggcgc cgcgcagccc gctcccgccg ccacctcctc ccctgccgcc      240

ctcctagccg gcaggaattg cgcgaccaca gcgccgctcg cgtcgcccgc atcagctcag      300

cccgctgccg ctcggccctc ggcaccgctc cgggtccggc cgccgcgcgg ccagggctcc      360

ccctgcccag cgctcccagg ccccgccacg cgtcgccgcg cccagctcca gtctcccctc      420

cccggggtct cgccagcccc ttcctgcagc cgccgcctcc gaaggagcgg gtccgccgcg      480

ggtaaccatg cctagcaaaa ccaagtacaa ccttgtggac gatgggcacg acctgcggat      540

ccccttgcac aacgaggacg ccttccagca cggcatctgc tttgaggcca agtacgtagg      600

aagcctggac gtgccaaggc ccaacagcag ggtggagatc gtggctgcca tgcgccggat      660

acggtatgag tttaaagcca agaacatcaa gaagaagaaa gtgagcatta tggtttcagt      720

ggatggagtg aaagtgattc tgaagaagaa gaaaaagctt cttttattgc agaaaaagga      780

atggacgtgg gatgagagca agatgctggt gatgcaggac cccatctaca ggatcttcta      840

tgtctctcat gattcccaag acttgaagat cttcagctat atcgctcgag atggtgccag      900

caatatcttc aggtgtaacg tctttaaatc caagaagaag agccaagcta tgagaatcgt      960

tcggacggtg gggcaggcct ttgaggtctg ccacaagctg agcctgcagc acacgcagca     1020

gaatgcagat ggccaggaag atggagagag cgagaggaac agcaacagct caggagaccc     1080

aggccgccag ctcactggag ccgagagggc ctccacggcc actgcagagg agactgacat     1140

cgatgcggtg gaggtcccac ttccagggaa tgatgtcctg gaattcagcc gaggtgtgac     1200

tgatctagat gctgtaggga aggaaggagg ctctcacaca ggctccaagg tttcgcaccc     1260

ccaggagccc atgctgacag cctcacccag gatgctgctc ccttcttctt cctcgaagcc     1320

tccaggcctg ggcacagaga caccgctgtc cactcaccac cagatgcagc tcctccagca     1380

gctcctccag cagcagcagc agcagacaca agtggctgtg gcccaggtac acttgctgaa     1440

ggaccagttg gctgctgagg ctgcggcgcg gctggaggcc caggctcgcg tgcatcagct     1500

tttgctgcag aacaaggaca tgctccagca catctccctg ctggtcaagc aggtgcaaga     1560

gctggaactg aagctgtcag gacagaacgc catgggctcc caggacagct tgctggagat     1620

caccttccgc tccggagccc tgcccgtgct ctgtgacccc acgaccccta agccagagga     1680

cctgcattcg ccgccgctgg gcgcgggctt ggctgacttt gcccaccctg cgggcagccc     1740

cttaggtagg cgcgactgct tggtgaagct ggagtgcttt cgctttcttc cgcccgagga     1800

caccccgccc ccagcgcagg gcgaggcgct cctgggcggt ctggagctca tcaagttccg     1860

agagtcaggc atcgcctcgg agtacgagtc caacacggac gagagcgagg agcgcgactc     1920

gtggtcccag gaggagctgc cgcgcctgct gaatgtcctg cagaggcagg aactgggcga     1980

cggcctggat gatgagatcg ccgtgtaggt gccgagggcg aggagatgga ggcggcggcg     2040

tggctggagg ggccgtgtct ggctgctgcc cgggtagggg atgcccagtg aatgtgcact     2100

gccgaggaga atgccagcca gggcccggga gagtgtgagg tttcaggaaa gtattgagat     2160

tctgctttgg agggtaaagt ggggaagaaa tcggattccc agaggtgaat cagctcctct     2220

cctacttgtg actagagggt ggtggaggta aggccttcca gagcccatgg cttcaggaga     2280

gggtctctct ccaggactgc caggctgctg gaggacctgc ccctacctgc tgcatcgtca     2340

ggctcccacg ctttgtccgt gatgcccccc taccccctca ctctccccgt ctccatggtc     2400

ccgaccagga agggaagcca tcggtacctt ctcaggtact ttgtttctgg atatcacgat     2460

gctgcgagtt gcctaaccct ccccctacct ttatgagagg aattccttct ccaggccctt     2520

gctgagattg tagagattga gtgctctgga ccgcaaaagc caggctagtc cttgtagggt     2580

gagcatggaa ttggaatgtg tcacagtgga taagctttta gaggaactga atccaaacat     2640

tttctccagc cggacattga atgttgctac aaagggagcc ttgaagcttt aacatggttc     2700

aggcccttgg tgtgagagcc cagggggagg acagcttgtc tgctgctcca aatcacttag     2760

atctgattcc tgttttgaaa gtcctgccct gccttcctcc tgcctgtagc ccagcccatc     2820

taaatggaag ctgggaattg cccctcacct cccctgtgtc ctgtccagct gaagcttttg     2880

cagcacttta cctctctgaa agccccagag gaccagagcc cccagcctta cctctcaacc     2940

tgtcccctcc actgggcagt ggtggtcagt ttttactgca aaaaaaaaaa aagaaaaaag     3000

agaaagaaaa aaaagaatga atgcaagctg atagctgaga ctgtgagact gtttttgtcc     3060

actcttctga atcactgcca cttgggtcag ggaccacagc cattgccacc cttggcccat     3120

ctctctgcgt gcgtgccttg agcacacata taaaaagtgc catgtgcaat tgtcttatct     3180

tttatgatct aggctttgcc tagggatcac tactccttaa cgggctggct ggggcaatga     3240

ggaaaagctc ctttgctcct gtaaggccat aagtggctgt taacagattt tcaaatgcct     3300

gaagagattg ctgagacctg ctagagtcat atgttcgggg aattaagtct ttatcctaga     3360

caacaaggta cagatgcaaa ctgcagtgtt attggagggt caatcggcaa ggatatgatt     3420

atcccaaaat ggagttcatc gaccctagct ttcctttaga ttatatataa ataaaagtgc     3480

agtcctcttc taatggccac agttggtttt cttgtagccc agaaagtcca aattaaagga     3540

aataaattca gttttatgtt agccttcctt ggtgcatcag ggtgtcagtg gaaataggat     3600

caggtggtgt gtgtgtgtgt gttttgtgtg tgtgtgtaca catgtgttta tatatacatg     3660

tgtgagggaa agtgtgtaca tatatgtagg attgtaacca gacggaaaag aacgaggatc     3720

tccagggtgt ttgaatcagc aacagatttg tgttttctaa catgcattta gttggagagg     3780

catggttctg tttgttttgt tttgatctaa tttgccattg gaaataggta cagttacaca     3840

gagaaggaag aaccaggaaa gtgagatcca tgaaactaaa tgagcagctg tcagaatcca     3900

gtgtggctga gcctacctag cttatgaaat ctaacccagg gttccctgag tccaagacca     3960

cttagattat taagattttg aacgtccaga ggagtgaaaa gtctgttttc tgacgtaagc     4020

cggagctgag gataaagcca gaggccagtg gattaggtgt atggaatgtg gatggagagg     4080

gcttgtgtgg gatgtggcca gggagtgggt gaggaaggcc gcttctaaat ggcctgtaaa     4140

aacttgagat tggatagacg aaaggaaatg gagaaattaa agaattggag aaactagtta     4200

tctgtgttgc tgactttggg acccatccaa gactcctgcc cttggggtgt tccatggtgg     4260

tttcttcctg cctgggcgcc accctttccc cagttcaggc cctccctgga ggactagttt     4320

gtgtattggt atcctcccca gtggacccaa accagcgcat acttggtgtg tggagatggg     4380

agacaaagga cagatctagg agccttgaag gatcaccagc caccgaccct ccatcagggc     4440

caactgggca ggaaagggaa cattgcagac ctgatttccc gacgatgtca ccctgtcctc     4500

cctccttgct tcttgctctg ctaactcaac tctgccttcc tctttttcat tcttctactc     4560

tgccctatat ggaggacaaa tggacaccag gggtgctaac cttattggtg cctgccccag     4620

cctaccccag gtgccagcag actctcgtgc acaggaggct cccacagtta tggagccagg     4680

aaagaatttc tctgcactgg atggactgta tattgagatt aaaaattata ttccttatat     4740

tcctgcttat atcaatgctc tctctgtaaa acctcttcct agcctcattt ctctcaactg     4800

atcttgttta ggcgttgtat tccttttatt tactctttgc ttgactgctt cctcctaacc     4860

ctctacccac tagcactcta cttcctaaag ctgttgtgtc attaactctg ttggatcaac     4920

tctctgggaa aagattctgt taatgtaagt gcacttactc cctggatgtt gtcactagtc     4980

tagtggcttt tgctaaataa acctttctta tttcta                               5016


<210>  22
<211>  506
<212>  PRT
<213>  Homo sapiens

<400>  22

Met Pro Ser Lys Thr Lys Tyr Asn Leu Val Asp Asp Gly His Asp Leu 
1               5                   10                  15      


Arg Ile Pro Leu His Asn Glu Asp Ala Phe Gln His Gly Ile Cys Phe 
            20                  25                  30          


Glu Ala Lys Tyr Val Gly Ser Leu Asp Val Pro Arg Pro Asn Ser Arg 
        35                  40                  45              


Val Glu Ile Val Ala Ala Met Arg Arg Ile Arg Tyr Glu Phe Lys Ala 
    50                  55                  60                  


Lys Asn Ile Lys Lys Lys Lys Val Ser Ile Met Val Ser Val Asp Gly 
65                  70                  75                  80  


Val Lys Val Ile Leu Lys Lys Lys Lys Lys Leu Leu Leu Leu Gln Lys 
                85                  90                  95      


Lys Glu Trp Thr Trp Asp Glu Ser Lys Met Leu Val Met Gln Asp Pro 
            100                 105                 110         


Ile Tyr Arg Ile Phe Tyr Val Ser His Asp Ser Gln Asp Leu Lys Ile 
        115                 120                 125             


Phe Ser Tyr Ile Ala Arg Asp Gly Ala Ser Asn Ile Phe Arg Cys Asn 
    130                 135                 140                 


Val Phe Lys Ser Lys Lys Lys Ser Gln Ala Met Arg Ile Val Arg Thr 
145                 150                 155                 160 


Val Gly Gln Ala Phe Glu Val Cys His Lys Leu Ser Leu Gln His Thr 
                165                 170                 175     


Gln Gln Asn Ala Asp Gly Gln Glu Asp Gly Glu Ser Glu Arg Asn Ser 
            180                 185                 190         


Asn Ser Ser Gly Asp Pro Gly Arg Gln Leu Thr Gly Ala Glu Arg Ala 
        195                 200                 205             


Ser Thr Ala Thr Ala Glu Glu Thr Asp Ile Asp Ala Val Glu Val Pro 
    210                 215                 220                 


Leu Pro Gly Asn Asp Val Leu Glu Phe Ser Arg Gly Val Thr Asp Leu 
225                 230                 235                 240 


Asp Ala Val Gly Lys Glu Gly Gly Ser His Thr Gly Ser Lys Val Ser 
                245                 250                 255     


His Pro Gln Glu Pro Met Leu Thr Ala Ser Pro Arg Met Leu Leu Pro 
            260                 265                 270         


Ser Ser Ser Ser Lys Pro Pro Gly Leu Gly Thr Glu Thr Pro Leu Ser 
        275                 280                 285             


Thr His His Gln Met Gln Leu Leu Gln Gln Leu Leu Gln Gln Gln Gln 
    290                 295                 300                 


Gln Gln Thr Gln Val Ala Val Ala Gln Val His Leu Leu Lys Asp Gln 
305                 310                 315                 320 


Leu Ala Ala Glu Ala Ala Ala Arg Leu Glu Ala Gln Ala Arg Val His 
                325                 330                 335     


Gln Leu Leu Leu Gln Asn Lys Asp Met Leu Gln His Ile Ser Leu Leu 
            340                 345                 350         


Val Lys Gln Val Gln Glu Leu Glu Leu Lys Leu Ser Gly Gln Asn Ala 
        355                 360                 365             


Met Gly Ser Gln Asp Ser Leu Leu Glu Ile Thr Phe Arg Ser Gly Ala 
    370                 375                 380                 


Leu Pro Val Leu Cys Asp Pro Thr Thr Pro Lys Pro Glu Asp Leu His 
385                 390                 395                 400 


Ser Pro Pro Leu Gly Ala Gly Leu Ala Asp Phe Ala His Pro Ala Gly 
                405                 410                 415     


Ser Pro Leu Gly Arg Arg Asp Cys Leu Val Lys Leu Glu Cys Phe Arg 
            420                 425                 430         


Phe Leu Pro Pro Glu Asp Thr Pro Pro Pro Ala Gln Gly Glu Ala Leu 
        435                 440                 445             


Leu Gly Gly Leu Glu Leu Ile Lys Phe Arg Glu Ser Gly Ile Ala Ser 
    450                 455                 460                 


Glu Tyr Glu Ser Asn Thr Asp Glu Ser Glu Glu Arg Asp Ser Trp Ser 
465                 470                 475                 480 


Gln Glu Glu Leu Pro Arg Leu Leu Asn Val Leu Gln Arg Gln Glu Leu 
                485                 490                 495     


Gly Asp Gly Leu Asp Asp Glu Ile Ala Val 
            500                 505     


<210>  23
<211>  5618
<212>  DNA
<213>  Homo sapiens

<400>  23
agcacatctg ggcgagagcg gcgccgctgg agccgagggg ggcgccgagc gcagatctgg       60

agcagcagag ccacggcgca gctggggccc ttcgaggcgc tcggggcgca catctgggac      120

ctcgagcggg ggccgtgccg cgcgcagctg gaccagggga ggggggcggc ggctgcacag      180

ctggaccgaa gggggcgggg tcggccctgg gcgacccgct gaggggaggg ccgcgggccg      240

ccggggactg gagcatggga cggcgcgcct gaaggagcag gaaggggaag gaggcctggg      300

accccgaaaa gagaagggga gagcgagggg acgagagcgg aggaggaaga tgcaactgac      360

tcgctgctgc ttcgtgttcc tggtgcaggg tagcctctat ctggtcatct gtggccagga      420

tgatggtcct cccggctcag aggaccctga gcgtgatgac cacgagggcc agccccggcc      480

ccgggtgcct cggaagcggg gccacatctc acctaagtcc cgccccatgg ccaattccac      540

tctcctaggg ctgctggccc cgcctgggga ggcttggggc attcttgggc agccccccaa      600

ccgcccgaac cacagccccc caccctcagc caaggtgaag aaaatctttg gctggggcga      660

cttctactcc aacatcaaga cggtggccct gaacctgctc gtcacaggga agattgtgga      720

ccatggcaat gggaccttca gcgtccactt ccaacacaat gccacaggcc agggaaacat      780

ctccatcagc ctcgtgcccc ccagtaaagc tgtagagttc caccaggaac agcagatctt      840

catcgaagcc aaggcctcca aaatcttcaa ctgccggatg gagtgggaga aggtagaacg      900

gggccgccgg acctcgcttt gcacccacga cccagccaag atctgctccc gagaccacgc      960

tcagagctca gccacctgga gctgctccca gcccttcaaa gtcgtctgtg tctacatcgc     1020

cttctacagc acggactatc ggctggtcca gaaggtgtgc ccagattaca actaccatag     1080

tgataccccc tactacccat ctgggtgacc cggggcaggc cacagaggcc aggccagggc     1140

tggaaggaca ggcctgccca tgcaggagac catctggaca ccgggcaggg aaggggttgg     1200

gcctcaggca gggagggggg tggagacgag gagatgccaa gtggggccag ggccaagtct     1260

caagtggcag agaaagggtc ccaagtgctg gtcccaacct gaagctgtgg agtgactaga     1320

tcacaggagc actggaggag gagtgggctc tctgtgcagc ctcacagggc tttgccacgg     1380

agccacagag agatgctggg tccccgaggc ctgtgggcag gccgatcagt gtggccccag     1440

atcaagtcat gggaggaagc taagcccttg gttcttgcca tcctgaggaa agatagcaac     1500

agggaggggg agatttcatc agtgtggaca gcctgtcaac ttaggatgga tggctgagag     1560

ggcttcctag gagccagtca gcagggtggg gtggggccag aggagctctc cagccctgcc     1620

tagtgggcgc cctcagcccc ttgtcgtgtg ctgagcatgg catgaggctg aagtggcaac     1680

cctggggtct ttgatgtctt gacagattga ccatctgtct ccagccaggc cacccctttc     1740

caaaattccc tcttctgcca gtactccccc tgtaccaccc attgctgatg gcacacccat     1800

ccttaagcta agacaggacg attgtggtcc tcccacacta aggccacagc ccatccgcgt     1860

gctgtgtgtc cctcttccac cccaacccct gctggctcct ctgggagcat ccatgtcccg     1920

gagaggggtc cctcaacagt cagcctcacc tgtcagaccg gggttctccc ggatctggat     1980

ggcgccgccc tctcagcagc gggcacgggt ggggcggggc cgggccgcag agcatgtgct     2040

ggatctgttc tgtgtgtctg tctgtgggtg gggggagggg agggaagtct tgtgaaaccg     2100

ctgattgctg acttttgtgt gaagaatcgt gttcttggag caggaaataa agcttgcccc     2160

ggggcactgg agtcagagtt gtccaaggaa agggcctcag gcatcccttg gtccaggaag     2220

aatttctctg atggccgcag gacatttgct tgagacccaa gtggcaggga tccaaccgcc     2280

cttggcgctg atgtttgctg agggctcagg gcttccctct ccagccccgg ttccaagctg     2340

tctgatcccc cacgaggaaa cttgagcaaa caccctgggc tcggtgctgg aggagggcgt     2400

agcatcttca agaacagctc agggagggag agctagcagg tagaatgggc caatgagggt     2460

gttccttggt gtcctccctg aactgccatc tgcagaccca gcagggtcct agccccgtca     2520

ttttgctgcg tggccttggc catgtccatt ctcctctctg gctttctttc tttgtttctt     2580

cctctatgac atgaagggct tgcccagacc aggggttctc aaacgcggat cacccagagg     2640

gtttgttaac acacagattt ctgggtccta cccacatttc taattcagca ggcctgggtg     2700

gggcctaaga attagaattt ctaacgagtg cccaggtcta tgctgatgct gctgctccag     2760

ggcccatgct gggagaccca ctcaaaggac cttgaagttc atctctggct atggctccgc     2820

aggaggggga gacacctcgg atgtgatttc ccagctgtaa tttccatctg cttctcctgg     2880

ggaaggggcc tttcagagaa tcggggctat tgtattggat tttcaatctg accacatgcc     2940

agtgaaggaa caggctggag tggggtgtgg acacagggcc tgcgtcagtc actcccctcc     3000

tgcagctagt aagaggcctc agaatggcca gctgccagtg gcaccttgtc tgggagttag     3060

ttgggccctt tgggactctg tgaagggaag acactaccaa ggtcacagtg ccttctggag     3120

gtcattctaa gtcggctctc ttgggagggc agcactcagg gccctttggg ccctcttgag     3180

gagaggagag tcctggcagt aaggtaagat gggcttgcca ccccccacct ttcgcccctg     3240

cccaccagcg ctccgcgcaa actggtcccc tcatactgca gcgcagagtt gggtggggct     3300

gagaagccat ctggttacag cccaccttgt aggaaatgac ccagcttgtt tcccccacat     3360

catgcttcca ggggccgtct ctcctgagtg gagatgtgag acacacaccc ctcctccaga     3420

ccaccctccg ctccccaccc tggaggcttg agactgctgg cactggagca gcccaccaat     3480

ggacacccac cgtgtgccgt tcagcctccc acagtgctgt ggagactgca ggaaggagga     3540

ggaagcaatg gggccagagg ccctgggcgc cctccccacc tcccctggct gaactctcag     3600

caggcactgg gggcactttg acccccctcc tgctcctctc ctcctgtgga gagccagatg     3660

ctggcgacag ctggagggcc cggccttcct ggcacacagt tctgcctgca ccagggatgg     3720

attcatttta ataacttcat ttcaccctca tgcacactgc cgcctcatcc ctcctttcca     3780

ccttccccag tagcctggct gctctcctca gctaggactt cgctaacaga tttcctccca     3840

aaccttaatt ctttggaata gccctctggt ccctactgtt cttgccagat acttctgtgc     3900

ccgcttggtc ctcacaaggg caaggggtcc atccaacttc ctctggctaa gaagacgtca     3960

cctctgcccc attggcgagc agtgtcccca tggtgatgcc cccccaccat cacgacgaag     4020

tgcgctggcc tcccactctt gccatgcaca cactcacagg agattcctct gaagaaacct     4080

gtccccactc tgcccagacc ccaaagggcc aggtcctact cacactccaa cccgttgacc     4140

ttccccatcc actgcccttc aaggcagtct gaaatgccct cagaccgttt agcggtcccg     4200

tggtcctcca ccctaacccc tcagcccagc tgggggctgc cgggggcctt gtctcctcca     4260

tcagtggagc ctctgggaca agtttaccag gctgggggtt ctttaaggac acagcttgga     4320

tctccccatc aggctgggga acacctaggg ccgggggcca tgcctccctc atcagactga     4380

ggacaccctg atgtcagggg ctggatggcc ccttagactg ggggtccctg agggcagaag     4440

ctatgcctcc cctcatcaga ctggagtctc cctgagggca agaactgtgc tatggatggg     4500

agggggacag cttgcctttt cctaggcatc agagcacctg gaggctgcct ctgcccttca     4560

gctttgctca aaggcgctgt ctgggtctca gcattccttt ctcaagtagg gtgaatctcc     4620

tagcactctg tgaagctaat aagggggatt acccgttagg tcaactggta gcaatgcccg     4680

agtctccttc tcgatgaagc ttaaggcaaa agcaaatgaa tatctaggtc ccttcccccc     4740

cttcccccct tccctttcct gggatgagca agcgggaact gagtcaccct gttccccatc     4800

cttggcagga atgctggtga ccttgcattg tggcagattc aggtggcgag gcccattgct     4860

cgagatgcac ctggtgggtg ggtggcaggg atcctggggg agtgtttatg gggacggagg     4920

cagctgaagg gcagggaggg gtgaccaggt gctgggatca tcgagtgagt atgtgcagga     4980

gggattgtag agacacaatg aaacagttgc tctgtgttgg gaagtgatcc agtgtcatcg     5040

ctgggagtgg gagacagaaa tgttacttcc aaagattccg agtcctgtgg tactgccagg     5100

agaaccgggg gctggggtga tgggtaagga gaggcaccat tagccccgcc aggcagaggc     5160

aagatggggt gggggcggca cctgccaatt atgccaaagt cttggagtgg cagctggcac     5220

catcaccaag gcacaaatgc cagcagagac ctggcactca cctgggttgt gattccatag     5280

ggcccctgtc tcctgttggt ctcccaggct caaaggctga cctgataatt caagtgaagg     5340

atgcctagtt caaggcctcc cagttcctca tcccaggcca cctggtcagg tggtcccaag     5400

ggacaagcta ggtcctcctg aactgcagag gctgccaata aactggcaac acaggtgttg     5460

caggaagata tagctgggtc ctcatcctgg gtctgtaatt tattagacgt gtggctttgg     5520

acaaatgaca taatttccca gagcctcctt agataaaaaa ctagggcttt gcttaccttg     5580

gcgtattgtt aggaaaatta aatgagttgc tcaataaa                             5618


<210>  24
<211>  252
<212>  PRT
<213>  Homo sapiens

<400>  24

Met Gln Leu Thr Arg Cys Cys Phe Val Phe Leu Val Gln Gly Ser Leu 
1               5                   10                  15      


Tyr Leu Val Ile Cys Gly Gln Asp Asp Gly Pro Pro Gly Ser Glu Asp 
            20                  25                  30          


Pro Glu Arg Asp Asp His Glu Gly Gln Pro Arg Pro Arg Val Pro Arg 
        35                  40                  45              


Lys Arg Gly His Ile Ser Pro Lys Ser Arg Pro Met Ala Asn Ser Thr 
    50                  55                  60                  


Leu Leu Gly Leu Leu Ala Pro Pro Gly Glu Ala Trp Gly Ile Leu Gly 
65                  70                  75                  80  


Gln Pro Pro Asn Arg Pro Asn His Ser Pro Pro Pro Ser Ala Lys Val 
                85                  90                  95      


Lys Lys Ile Phe Gly Trp Gly Asp Phe Tyr Ser Asn Ile Lys Thr Val 
            100                 105                 110         


Ala Leu Asn Leu Leu Val Thr Gly Lys Ile Val Asp His Gly Asn Gly 
        115                 120                 125             


Thr Phe Ser Val His Phe Gln His Asn Ala Thr Gly Gln Gly Asn Ile 
    130                 135                 140                 


Ser Ile Ser Leu Val Pro Pro Ser Lys Ala Val Glu Phe His Gln Glu 
145                 150                 155                 160 


Gln Gln Ile Phe Ile Glu Ala Lys Ala Ser Lys Ile Phe Asn Cys Arg 
                165                 170                 175     


Met Glu Trp Glu Lys Val Glu Arg Gly Arg Arg Thr Ser Leu Cys Thr 
            180                 185                 190         


His Asp Pro Ala Lys Ile Cys Ser Arg Asp His Ala Gln Ser Ser Ala 
        195                 200                 205             


Thr Trp Ser Cys Ser Gln Pro Phe Lys Val Val Cys Val Tyr Ile Ala 
    210                 215                 220                 


Phe Tyr Ser Thr Asp Tyr Arg Leu Val Gln Lys Val Cys Pro Asp Tyr 
225                 230                 235                 240 


Asn Tyr His Ser Asp Thr Pro Tyr Tyr Pro Ser Gly 
                245                 250         


<210>  25
<211>  2608
<212>  DNA
<213>  Homo sapiens

<400>  25
agacgcgccg gaaccgggac gcgataaata tgcagagcgg aggcttcgcg cagcagagcc       60

cgcgcgccgc ccgctccggg tgctgaatcc aggcgtgggg acacgagcca ggcgccgccg      120

ccggagccag cggagccggg gccagagccg gagcgcgtcc gcgtccacgc agccgccggc      180

cggccagcac ccagggccct gcatgccagg tcgttggagg tggcagcgag acatgcaccc      240

ggcccggaag ctcctcagcc tcctcttcct catcctgatg ggcactgaac tcactcaagt      300

gctgcccacc aaccctgagg agagctggca ggtgtacagc tctgcccagg acagcgaggg      360

caggtgtatc tgcacagtgg tcgctccaca gcagaccatg tgttcacggg atgcccgcac      420

aaaacagctg aggcagctac tggagaaggt gcagaacatg tctcaatcca tagaggtctt      480

ggacaggcgg acccagagag acttgcagta cgtggagaag atggagaacc aaatgaaagg      540

actggagtcc aagttcaaac aggtggagga gagtcataag caacacctgg ccaggcagtt      600

taaggcgata aaagcgaaaa tggatgaact taggcctttg atacctgtgt tggaagagta      660

caaggccgat gccaaattgg tattgcagtt taaagaggag gtccagaatc tgacgtcagt      720

gcttaacgag ctgcaagagg aaattggcgc ctatgactac gatgaacttc agagcagagt      780

gtccaatctt gaagaaaggc tccgtgcatg catgcaaaaa ctagcttgcg ggaagttgac      840

gggcatcagt gaccccgtga ctgtcaagac ctccggctcg aggttcggat cctggatgac      900

agaccctctc gcccctgaag gcgataaccg ggtgtggtac atggacggct atcacaacaa      960

ccgcttcgta cgtgagtaca agtccatggt tgacttcatg aacacggaca atttcacctc     1020

ccaccgtctc ccccacccct ggtcgggcac ggggcaggtg gtctacaacg gttctatcta     1080

cttcaacaag ttccagagcc acatcatcat caggtttgac ctgaagacag agaccatcct     1140

caagacccgc agcctggact atgccggtta caacaacatg taccactacg cctggggtgg     1200

ccactcggac atcgacctca tggtggacga gagcgggctg tgggccgtgt acgccaccaa     1260

ccagaacgct ggcaacatcg tggtcagtag gctggacccc gtgtccctgc agaccctgca     1320

gacctggaac acgagctacc ccaagcgcag cgccggggag gccttcatca tctgcggcac     1380

gctgtacgtc accaacggct actcaggggg taccaaggtc cactatgcat accagaccaa     1440

tgcctccacc tatgaataca tcgacatccc attccagaac aaatactccc acatctccat     1500

gctggactac aaccccaagg accgggccct gtatgcctgg aacaacggcc accagatcct     1560

ctacaacgtg accctcttcc acgtcatccg ctccgacgag ttgtagctcc ctcctcctgg     1620

aagccaaggg cccacgtcct caccacaaag ggactcctgt gaaactgctg ccaaaaagat     1680

accaataaca ctaacaatac cgatcttgaa aaatcatcag cagtgcggat tctgacatcg     1740

agggatggca ttacctccgt gtttctccct ttcgagccgg cgggccacag acgtcggaag     1800

aaactcccgt atttgcagct ggaactgcag cccacggcgc cccggttttc ctccccgccc     1860

tgtccctctc tggtcaaaca acatactaaa gaggcgaggc aatgactgtt ggccagttct     1920

caccggggaa aaacccactg ttaggatggc atgaacattt ccttagatcg tggtcagctc     1980

cgaggaatgt ggcgtccagg ctctttgaga gccatgggct gcacccggcc gtaggctagt     2040

gtaactcgca tcccattgca gtgccgtttc ttgactgtgt tgctgtctct tagattaacc     2100

gtgctgaggc tccacatagc tcctggacct gtgtctagta catactgaag cgatggtcag     2160

agtgtgtaga gtgaagttgc tgtgcccaca ttgtttgaac tcgcgtaccc cgtagataca     2220

ttgtgcaacg ttcttctgtt attcccttga ggtggtaact tcgtatgttc agtttatgcg     2280

atgattgttg taaatgcaat gccgtagttt ggattaataa gtggatggtt tttgtttcta     2340

aaaagaaaaa aaaaatcagt gttcaccctt atagagacat agtcaagttc atgttgataa     2400

taatcaaagg aattactctc ttcttgttaa attagctaaa tcatgtaacc gcagatagga     2460

agggctcgcc tggggaaact ctggtttccg atgggacagg aaagtcatac gggcaacagt     2520

atgcggaaag tacgtttttt aagtaaaaaa caaaggcaaa ctttgtacta tccagttatc     2580

taaggaacaa taaaaacatt aggagatc                                        2608


<210>  26
<211>  485
<212>  PRT
<213>  Homo sapiens

<400>  26

Met Ser Val Pro Leu Leu Lys Ile Gly Val Val Leu Ser Thr Met Ala 
1               5                   10                  15      


Met Ile Thr Asn Trp Met Ser Gln Thr Leu Pro Ser Leu Val Gly Leu 
            20                  25                  30          


Asn Thr Thr Lys Leu Ser Ala Ala Gly Gly Gly Thr Leu Asp Arg Ser 
        35                  40                  45              


Thr Gly Val Leu Pro Thr Asn Pro Glu Glu Ser Trp Gln Val Tyr Ser 
    50                  55                  60                  


Ser Ala Gln Asp Ser Glu Gly Arg Cys Ile Cys Thr Val Val Ala Pro 
65                  70                  75                  80  


Gln Gln Thr Met Cys Ser Arg Asp Ala Arg Thr Lys Gln Leu Arg Gln 
                85                  90                  95      


Leu Leu Glu Lys Val Gln Asn Met Ser Gln Ser Ile Glu Val Leu Asp 
            100                 105                 110         


Arg Arg Thr Gln Arg Asp Leu Gln Tyr Val Glu Lys Met Glu Asn Gln 
        115                 120                 125             


Met Lys Gly Leu Glu Ser Lys Phe Lys Gln Val Glu Glu Ser His Lys 
    130                 135                 140                 


Gln His Leu Ala Arg Gln Phe Lys Ala Ile Lys Ala Lys Met Asp Glu 
145                 150                 155                 160 


Leu Arg Pro Leu Ile Pro Val Leu Glu Glu Tyr Lys Ala Asp Ala Lys 
                165                 170                 175     


Leu Val Leu Gln Phe Lys Glu Glu Val Gln Asn Leu Thr Ser Val Leu 
            180                 185                 190         


Asn Glu Leu Gln Glu Glu Ile Gly Ala Tyr Asp Tyr Asp Glu Leu Gln 
        195                 200                 205             


Ser Arg Val Ser Asn Leu Glu Glu Arg Leu Arg Ala Cys Met Gln Lys 
    210                 215                 220                 


Leu Ala Cys Gly Lys Leu Thr Gly Ile Ser Asp Pro Val Thr Val Lys 
225                 230                 235                 240 


Thr Ser Gly Ser Arg Phe Gly Ser Trp Met Thr Asp Pro Leu Ala Pro 
                245                 250                 255     


Glu Gly Asp Asn Arg Val Trp Tyr Met Asp Gly Tyr His Asn Asn Arg 
            260                 265                 270         


Phe Val Arg Glu Tyr Lys Ser Met Val Asp Phe Met Asn Thr Asp Asn 
        275                 280                 285             


Phe Thr Ser His Arg Leu Pro His Pro Trp Ser Gly Thr Gly Gln Val 
    290                 295                 300                 


Val Tyr Asn Gly Ser Ile Tyr Phe Asn Lys Phe Gln Ser His Ile Ile 
305                 310                 315                 320 


Ile Arg Phe Asp Leu Lys Thr Glu Thr Ile Leu Lys Thr Arg Ser Leu 
                325                 330                 335     


Asp Tyr Ala Gly Tyr Asn Asn Met Tyr His Tyr Ala Trp Gly Gly His 
            340                 345                 350         


Ser Asp Ile Asp Leu Met Val Asp Glu Ser Gly Leu Trp Ala Val Tyr 
        355                 360                 365             


Ala Thr Asn Gln Asn Ala Gly Asn Ile Val Val Ser Arg Leu Asp Pro 
    370                 375                 380                 


Val Ser Leu Gln Thr Leu Gln Thr Trp Asn Thr Ser Tyr Pro Lys Arg 
385                 390                 395                 400 


Ser Ala Gly Glu Ala Phe Ile Ile Cys Gly Thr Leu Tyr Val Thr Asn 
                405                 410                 415     


Gly Tyr Ser Gly Gly Thr Lys Val His Tyr Ala Tyr Gln Thr Asn Ala 
            420                 425                 430         


Ser Thr Tyr Glu Tyr Ile Asp Ile Pro Phe Gln Asn Lys Tyr Ser His 
        435                 440                 445             


Ile Ser Met Leu Asp Tyr Asn Pro Lys Asp Arg Ala Leu Tyr Ala Trp 
    450                 455                 460                 


Asn Asn Gly His Gln Ile Leu Tyr Asn Val Thr Leu Phe His Val Ile 
465                 470                 475                 480 


Arg Ser Asp Glu Leu 
                485 


<210>  27
<211>  13037
<212>  DNA
<213>  Homo sapiens

<400>  27
agtccacagc tgtcactaat cggggtaagc cttgttgtat ttgtgcgtgt gggtggcatt       60

ctcaatgaga actagcttca cttgtcattt gagtgaaatc tacaacccga ggcggctagt      120

gctcccgcac tactgggatc tgagatcttc ggagatgact gtcgcccgca gtacggagcc      180

agcagaagtc cgacccttcc tgggaatggg ctgtaccgag aggtccgact agccccaggg      240

ttttagtgag ggggcagtgg aactcagcga gggactgaga gcttcacagc atgcacgagt      300

ttgatgccag agaaaaagtc gggagataaa ggagccgcgt gtcactaaat tgccgtcgca      360

gccgcagcca ctcaagtgcc ggacttgtga gtactctgcg tctccagtcc tcggacagaa      420

gttggagaac tctcttggag aactccccga gttaggagac gagatctcct aacaattact      480

actttttctt gcgctcccca cttgccgctc gctgggacaa acgacagcca cagttcccct      540

gacgacagga tggaggccaa gggcaggagc tgaccagcgc cgccctcccc cgcccccgac      600

ccaggaggtg gagatccctc cggtccagcc acattcaaca cccactttct cctccctctg      660

cccctatatt cccgaaaccc cctcctcctt cccttttccc tcctcctgga gacgggggag      720

gagaaaaggg gagtccagtc gtcatgactg agctgaaggc aaagggtccc cgggctcccc      780

acgtggcggg cggcccgccc tcccccgagg tcggatcccc actgctgtgt cgcccagccg      840

caggtccgtt cccggggagc cagacctcgg acaccttgcc tgaagtttcg gccataccta      900

tctccctgga cgggctactc ttccctcggc cctgccaggg acaggacccc tccgacgaaa      960

agacgcagga ccagcagtcg ctgtcggacg tggagggcgc atattccaga gctgaagcta     1020

caaggggtgc tggaggcagc agttctagtc ccccagaaaa ggacagcgga ctgctggaca     1080

gtgtcttgga cactctgttg gcgccctcag gtcccgggca gagccaaccc agccctcccg     1140

cctgcgaggt caccagctct tggtgcctgt ttggccccga acttcccgaa gatccaccgg     1200

ctgcccccgc cacccagcgg gtgttgtccc cgctcatgag ccggtccggg tgcaaggttg     1260

gagacagctc cgggacggca gctgcccata aagtgctgcc ccggggcctg tcaccagccc     1320

ggcagctgct gctcccggcc tctgagagcc ctcactggtc cggggcccca gtgaagccgt     1380

ctccgcaggc cgctgcggtg gaggttgagg aggaggatgg ctctgagtcc gaggagtctg     1440

cgggtccgct tctgaagggc aaacctcggg ctctgggtgg cgcggcggct ggaggaggag     1500

ccgcggctgt cccgccgggg gcggcagcag gaggcgtcgc cctggtcccc aaggaagatt     1560

cccgcttctc agcgcccagg gtcgccctgg tggagcagga cgcgccgatg gcgcccgggc     1620

gctccccgct ggccaccacg gtgatggatt tcatccacgt gcctatcctg cctctcaatc     1680

acgccttatt ggcagcccgc actcggcagc tgctggaaga cgaaagttac gacggcgggg     1740

ccggggctgc cagcgccttt gccccgccgc ggagttcacc ctgtgcctcg tccaccccgg     1800

tcgctgtagg cgacttcccc gactgcgcgt acccgcccga cgccgagccc aaggacgacg     1860

cgtaccctct ctatagcgac ttccagccgc ccgctctaaa gataaaggag gaggaggaag     1920

gcgcggaggc ctccgcgcgc tccccgcgtt cctaccttgt ggccggtgcc aaccccgcag     1980

ccttcccgga tttcccgttg gggccaccgc ccccgctgcc gccgcgagcg accccatcca     2040

gacccgggga agcggcggtg acggccgcac ccgccagtgc ctcagtctcg tctgcgtcct     2100

cctcggggtc gaccctggag tgcatcctgt acaaagcgga gggcgcgccg ccccagcagg     2160

gcccgttcgc gccgccgccc tgcaaggcgc cgggcgcgag cggctgcctg ctcccgcggg     2220

acggcctgcc ctccacctcc gcctctgccg ccgccgccgg ggcggccccc gcgctctacc     2280

ctgcactcgg cctcaacggg ctcccgcagc tcggctacca ggccgccgtg ctcaaggagg     2340

gcctgccgca ggtctacccg ccctatctca actacctgag gccggattca gaagccagcc     2400

agagcccaca atacagcttc gagtcattac ctcagaagat ttgtttaatc tgtggggatg     2460

aagcatcagg ctgtcattat ggtgtcctta cctgtgggag ctgtaaggtc ttctttaaga     2520

gggcaatgga agggcagcac aactacttat gtgctggaag aaatgactgc atcgttgata     2580

aaatccgcag aaaaaactgc ccagcatgtc gccttagaaa gtgctgtcag gctggcatgg     2640

tccttggagg tcgaaaattt aaaaagttca ataaagtcag agttgtgaga gcactggatg     2700

ctgttgctct cccacagcca gtgggcgttc caaatgaaag ccaagcccta agccagagat     2760

tcactttttc accaggtcaa gacatacagt tgattccacc actgatcaac ctgttaatga     2820

gcattgaacc agatgtgatc tatgcaggac atgacaacac aaaacctgac acctccagtt     2880

ctttgctgac aagtcttaat caactaggcg agaggcaact tctttcagta gtcaagtggt     2940

ctaaatcatt gccaggtttt cgaaacttac atattgatga ccagataact ctcattcagt     3000

attcttggat gagcttaatg gtgtttggtc taggatggag atcctacaaa cacgtcagtg     3060

ggcagatgct gtattttgca cctgatctaa tactaaatga acagcggatg aaagaatcat     3120

cattctattc attatgcctt accatgtggc agatcccaca ggagtttgtc aagcttcaag     3180

ttagccaaga agagttcctc tgtatgaaag tattgttact tcttaataca attcctttgg     3240

aagggctacg aagtcaaacc cagtttgagg agatgaggtc aagctacatt agagagctca     3300

tcaaggcaat tggtttgagg caaaaaggag ttgtgtcgag ctcacagcgt ttctatcaac     3360

ttacaaaact tcttgataac ttgcatgatc ttgtcaaaca acttcatctg tactgcttga     3420

atacatttat ccagtcccgg gcactgagtg ttgaatttcc agaaatgatg tctgaagtta     3480

ttgctgcaca attacccaag atattggcag ggatggtgaa accccttctc tttcataaaa     3540

agtgaatgtc atctttttct tttaaagaat taaattttgt ggtatgtctt tttgttttgg     3600

tcaggattat gaggtcttga gtttttataa tgttcttctg aaagccttac atttataaca     3660

tcatagtgtg taaatttaaa agaaaaattg tgaggttcta attattttct tttataaagt     3720

ataattagaa tgtttaactg ttttgtttac ccatattttc ttgaagaatt tacaagattg     3780

aaaaagtact aaaattgtta aagtaaacta tcttatccat attatttcat accatgtagg     3840

tgaggatttt taacttttgc atctaacaaa tcatcgactt aagagaaaaa atcttacatg     3900

taataacaca aagctattat atgttatttc taggtaactc cctttgtgtc aattatattt     3960

ccaaaaatga acctttaaaa tggtatgcaa aattttgtct atatatattt gtgtgaggag     4020

gaaattcata actttcctca gattttcaaa agtattttta atgcaaaaaa tgtagaaaga     4080

gtttaaaacc actaaaatag attgatgttc ttcaaactag gcaaaacaac tcatatgtta     4140

agaccatttt ccagattgga aacacaaatc tcttaggaag ttaataagta gattcatatc     4200

attatgcaaa tagtattgtg ggttttgtag gtttttaaaa taaccttttt tggggagaga     4260

attgtcctct aatgaggtat tgcgagtgga cataagaaat cagaagatta tggcctaact     4320

gtactcctta ccaactgtgg catgctgaaa gttagtcact cttactgatt ctcaattctc     4380

tcacctttga aagtagtaaa atatctttcc tgccaattgc tcctttgggt cagagcttat     4440

taacatcttt tcaaatcaaa ggaaagaaga aagggagagg aggaggaggg aggtatcaat     4500

tcacatacct ttctcctctt tatcctccac tatcatgaat tcatattatg tttcagccat     4560

gcaaatcttt ttaccatgaa atttcttcca gaattttccc cctttgacac aaattccatg     4620

catgtttcaa ccttcgagac tcagccaaat gtcatttctg taaaatcttc cctgagtctt     4680

ccaagcagta atttgccttc tcctagagtt tacctgccat tttgtgcaca tttgagttac     4740

agtagcatgt tattttacaa ttgtgactct cctgggagtc tgggagccat ataaagtggt     4800

caatagtgtt tgctgactga gagttgaatg acattttctc tctgtcttgg tattactgta     4860

gatttcgatc attctttggt tacatttctg catatttctg tacccatgac tttatcactt     4920

tcttctccca tgctttatct ccatcaatta tcttcattac ttttaaattt tccacctttg     4980

cttcctactt tgtgagatct ctccctttac tgactataac atagaagaat agaagtgtat     5040

tttatgtgtc ttaaggacaa tactttagat tccttgttct aagtttttaa actgaatgaa     5100

tggaatatta tttctctccc taagcaaaat tccacaaaac aattatttct tatgtttatg     5160

tagccttaaa ttgttttgta ctgtaaacct cagcataaaa actttcttca tttctaattt     5220

cattcaacaa atattgattg aatacctggt attagcacaa gaaaaatgtg ctaataagcc     5280

ttatgagaat ttggagctga agaaagacat ataactcagg aaagttacag tccagtagta     5340

ggtataaatt acagtgcctg ataaataggc attttaatat ttgtacactc aacgtatact     5400

aggtaggtgc aaaacattta catataattt tactgatacc catgcagcac aaaggtacta     5460

actttaaata ttaaataaca cctttatgtg tcagtaattc atttgcatta aatcttattg     5520

aaaaggcttt caatatattt tccccacaaa tgtcatccca agaaaaaagt atttttaaca     5580

tctcccaaat ataatagtta caggaaatct acctctgtga gagtgacacc tctcagaatg     5640

aactgtgtga cacaagaaaa tgaatgtagg tctatccaaa aaaaacccca agaaacaaaa     5700

acaatattat tagcccttta tgcttaagtg atggactcag ggaacagttg atgttgtgat     5760

cattttatta tctgattctt gttactttga attaaaccaa tattttgatg atataaatca     5820

tttccaccag catatattta atttccataa taactttaaa attttctaat ttcactcaac     5880

tatgagggaa tagaatgtgg tggccacagg tttggctttt gttaaaatgt ttgatatctt     5940

cgatgttgat ctctgtctgc aatgtagatg tctaaacact aggatttaat atttaaggct     6000

aagctttaaa aataaagtac ctttttaaaa agaatatggc ttcaccaaat ggaaaatacc     6060

taatttctaa atctttttct ctacaaagtc ctatctacta atgtctccat tactatttag     6120

tcatcataac cattatcttc attttacatg tcgtgttctt tctggtagct ctaaaatgac     6180

actaaatcat aagaagacag gttacatatc aggaaatact tgaaggttac tgaaatagat     6240

tcttgagtta atgaaaatat tttctgtaaa aaggtttgaa aagccatttg agtctaaagc     6300

attatacctc cattatcagt agttatgtga caattgtgtg tgtgtttaat gtttaaagat     6360

gtggcacttt ttaataaggc aatgctatgc tattttttcc catttaacat taagataatt     6420

tattgctata cagatgatat ggaaatatga tgaacaatat tttttttgcc aaaactatgc     6480

cttgtaagta gccatggaat gtcaacctgt aacttaaatt atccacagat agtcatgtgt     6540

ttgatgatgg gcactgtgga gataactgac ataggactgt gccccccttc tctgccactt     6600

actagctgga tgagattaag caagtcattt aactgctctg attaaacctg cctttcccaa     6660

gtgctttgta atgaatagaa atggaaacca aaaaaaacgt atacaggcct tcagaaatag     6720

taattgctac tattttgttt tcattaagcc atagttctgg ctataatttt atcaaactca     6780

ccagctatat tctacagtga aagcaggatt ctagaaagtc tcactgtttt atttatgtca     6840

ccatgtgcta tgatatattt ggttgaattc atttgaaatt agggctggaa gtattcaagt     6900

aatttcttct gctgaaaaaa tacagtgttt tgagtttagg gcctgtttta tcaaagttct     6960

aaagagccta tcactcttcc attgtagaca ttttaaaata atgacactga ttttaacatt     7020

tttaagtgtc tttttagaac agagagcctg actagaacac agcccctcca aaaacccatg     7080

ctcaaattat ttttactatg gcagcaattc cacaaaaggg aacaatgggt ttagaaatta     7140

caatgaagtc atcaacccaa aaaacatccc tatccctaag aaggttatga tataaaatgc     7200

ccacaagaaa tctatgtctg ctttaatctg tcttttattg ctttggaagg atggctatta     7260

catttttagt ttttgctgtg aatacctgag cagtttctct catccatact tatccttcac     7320

acatcagaag tcaggataga atatgaatca ttttaaaaac ttttacaact ccagagccat     7380

gtgcataaga agcattcaaa acttgccaaa acatacattt tttttcaaat ttaaagatac     7440

tctatttttg tattcaatag ctcaacaact gtggtcccca ctgataaagt gaagtggaca     7500

aggagacaag taatggcata agtttgtttt tcccaaagta tgcctgttca atagccattg     7560

gatgtgggaa atttctacat ctcttaaaat tttacagaaa atacatagcc agatagtcta     7620

gcaaaagttc accaagtcct aaattgctta tccttacttc actaagtcat gaaatcattt     7680

taatgaaaag aacatcacct aggttttgtg gtttcttttt ttcttattca tggctgagtg     7740

aaaacaacaa tctctgtttc tccctagcat ctgtggacta tttaatgtac cattattcca     7800

cactctatgg tccttactaa atacaaaatt gaacaaaaag cagtaaaaca actgactctt     7860

cacccatatt ataaaatata atccaagcca gattagtcaa catccataag atgaatccaa     7920

gctgaactgg gcctagatta ttgagttcag gttggatcac atccctattt attaataaac     7980

ttaggaaaga aggccttaca gaccatcagt tagctggagc taatagaacc tacacttcta     8040

aagttcggcc tagaatcaat gtggccttaa aagctgaaaa gaagcaggaa agaacagttt     8100

tcttcaataa tttgtccacc ctgtcactgg agaaaattta agaatttggg ggtgttggta     8160

gtaagttaaa cacagcagct gttcatggca gaaattattc aatacatacc ttctctgaat     8220

atcctataac caaagcaaag aaaaacacca aggggtttgt tctcctcctt ggagttgacc     8280

tcattccaag gcagagctca ggtcacaggc acaggggctg cgcccaagct tgtccgcagc     8340

cttatgcagc tgtggagtct ggaagactgt tgcaggactg ctggcctagt cccagaatgt     8400

cagcctcatt ttcgatttac tggctcttgt tgctgtatgt catgctgacc ttattgttaa     8460

acacaggttt gtttgctttt tttccactca tggagacatg ggagaggcat tatttttaag     8520

ctggttgaaa gctttaaccg ataaagcatt tttagagaaa tgtgaatcag gcagctaaga     8580

aagcatactc tgtccattac ggtaaagaaa atgcacagat tattaactct gcagtgtggc     8640

attagtgtcc tggtcaatat tcggatagat atgaataaaa tatttaaatg gtattgtaaa     8700

tagttttcag gacatatgct atagcttatt tttattatct tttgaaattg ctcttaatac     8760

atcaaatcct gatgtattca atttatcaga tataaattat tctaaatgaa gcccagttaa     8820

atgtttttgt cttgtcagtt atatgttaag tttctgatct ctttgtctat gacgtttact     8880

aatctgcatt tttactgtta tgaattattt tagacagcag tggtttcaag ctttttgcca     8940

ctaaaaatac cttttatttt ctcctccccc agaaaagtct ataccttgaa gtatctatcc     9000

accaaactgt acttctatta agaaatagtt attgtgtttt cttaatgttt tgttattcaa     9060

agacatatca atgaaagctg ctgagcagca tgaataacaa ttatatccac acagatttga     9120

tatattttgt gcagccttaa cttgatagta taaaatgtca ttgcttttta aataatagtt     9180

agtcaatgga cttctatcat agctttccta aactaggtta agatccagag ctttggggtc     9240

ataatatatt acatacaatt aagttatctt tttctaaggg ctttaaaatt catgagaata     9300

accaaaaaag gtatgtggag agttaataca aacataccat attcttgttg aaacagagat     9360

gtggctctgc ttgttctcca taaggtagaa atactttcca gaatttgcct aaactagtaa     9420

gccctgaatt tgctatgatt agggatagga agagattttc acatggcaga ctttagaatt     9480

cttcacttta gccagtaaag tatctccttt tgatcttagt attctgtgta ttttaacttt     9540

tctgagttgt gcatgtttat aagaaaaatc agcacaaagg gtttaagtta aagccttttt     9600

actgaaattt gaaagaaaca gaagaaaata tcaaagttct ttgtattttg agaggattaa     9660

atatgattta caaaagttac atggagggct ctctaaaaca ttaaattaat tattttttgt     9720

tgaaaagtct tactttaggc atcattttat tcctcagcaa ctagctgtga agcctttact     9780

gtgctgtatg ccagtcactc tgctagattg tggagattac cagtgttccc gtcttctccg     9840

agcttagagt tggatgggga ataaagacag gtaaacagat agctacaata ttgtactgtg     9900

aatgcttatg ctggaggaag tacagggaac tattggagca cctaagagga gcacctacct     9960

tgaatttagg ggttagcaga ggcatcctga aaaaagtcaa agctaagcca caatctataa    10020

gcagtttagg aattagcaga acgtgcgtgg tgaggagatg ccaaaggcaa gaagagaaga    10080

gtattccaaa caggagggat tccaaagaga gaagagtatc ccaaacaaca tttgcacaaa    10140

cctgatgggg agagagaatg tggggtgggg atggatgatg agactgaaga agaaagccag    10200

gtctagataa tcagtggcct tgtacaccat gttaaagagt gtagacttga ttctgttgta    10260

aacaggaaag cagcacaatt catatgaata ttttagaaga ctcccactgg aatatggaga    10320

ataaagttgg agatgactaa tcctggaagc agggagaaca tttttgagga agttgcacta    10380

ttttggtgaa aatgatgatc ataaacatga agaattgtag gtgatcatga cctcctctct    10440

aattttccag aagggttttg gaagatataa cataggaaca ttgacaggac tgacgaaagg    10500

agatgaaata caccatataa attgtcaaac acaaggccag atgtctaatt attttgctta    10560

tgtgttgaaa ttacaaattt ttcatcagga aaccaaaaac tacaaaactt agttttccca    10620

agtcccagaa ttctatctgt ccaaacaatc tgtaccactc cacctatatc cctacctttg    10680

catgtctgtc caacctcaaa gtccaggtct atacacacgg gtaagactag agcagttcaa    10740

gtttcagaaa atgagaaaga ggaactgagt tgtgctgaac ccatacaaaa taaacacatt    10800

ctttgtatag attcttggaa cctcgagagg aattcaccta actcataggt atttgatggt    10860

atgaatccat ggctgggctc ggcttttaaa aagccttatc tgggattcct tctatggaac    10920

caagttccat caaagcccat ttaaaagcct acattaaaaa caaaattctt gctgcattgt    10980

atacaaataa tgatgtcatg atcaaataat cagatgccat tatcaagtgg aattacaaaa    11040

tggtataccc actccaaaaa aaaaaaaaaa gctaaattct cagtagaaca ttgtgacttc    11100

atgagccctc cacagccttg gagctgagga gggagcactg gtgagcagta ggttgaagag    11160

aaaacttggc gcttaataat ctatccatgt tttttcatct aaaagagcct tctttttgga    11220

ttaccttatt caatttccat caaggaaatt gttagttcca ctaaccagac agcagctggg    11280

aaggcagaag cttactgtat gtacatggta gctgtgggaa ggaggtttct ttctccaggt    11340

cctcactggc catacaccag tcccttgtta gttatgcctg gtcatagacc cccgttgcta    11400

tcatctcata tttaagtctt tggcttgtga atttatctat tctttcagct tcagcactgc    11460

agagtgctgg gactttgcta acttccattt cttgctggct tagcacattc ctcataggcc    11520

cagctctttt ctcatctggc cctgctgtgg agtcaccttg ccccttcagg agagccatgg    11580

cttaccactg cctgctaagc ctccactcag ctgccaccac actaaatcca agcttctcta    11640

agatgttgca gactttacag gcaagcataa aaggcttgat cttcctggac ttccctttac    11700

ttgtctgaat ctcacctcct tcaactttca gtctcagaat gtaggcattt gtcctctttg    11760

ccctacatct tccttcttct gaatcatgaa agcctctcac ttcctcttgc tatgtgctgg    11820

aggcttctgt caggttttag aatgagttct catctagtcc tagtagcttt tgatgcttaa    11880

gtccaccttt taaggatacc tttgagattt agaccatgtt tttcgcttga gaaagcccta    11940

atctccagac ttgcctttct gtggatttca aagaccaact gaggaagtca aaagctgaat    12000

gttgactttc tttgaacatt tccgctataa caattccaat tctcctcaga gcaatatgcc    12060

tgcctccaac tgaccaggag aaaggtccag tgccaaagag aaaaacacaa agattaatta    12120

tttcagttga gcacatactt tcaaagtggt ttgggtattc atatgaggtt ttctgtcaag    12180

agggtgagac tcttcatcta tccatgtgtg cctgacagtt ctcctggcac tggctggtaa    12240

cagatgcaaa actgtaaaaa ttaagtgatc atgtatttta acgatatcat cacatactta    12300

ttttctatgt aatgttttaa atttccccta acatactttg actgttttgc acatggtaga    12360

tattcacatt tttttgtgtt gaagttgatg caatcttcaa agttatctac cccgttgctt    12420

attagtaaaa ctagtgttaa tacttggcaa gagatgcagg gaatctttct catgactcac    12480

gccctattta gttattaatg ctactaccct attttgagta agtagtaggt ccctaagtac    12540

attgtccaga gttatacttt taaagatatt tagccccata tacttcttga atctaaagtc    12600

atacaccttg ctcctcattt ctgagtggga aagacatttg agagtatgtt gacaattgtt    12660

ctgaaggttt ttgccaagaa ggtgaaactg tcctttcatc tgtgtatgcc tggggctggg    12720

tccctggcag tgatggggtg acaatgcaaa gctgtaaaaa ctaggtgcta gtgggcacct    12780

aatatcatca tcatatactt attttcaagc taatatgcaa aatcccatct ctgtttttaa    12840

actaagtgta gatttcagag aaaatatttt gtggttcaca taagaaaaca gtctactcag    12900

cttgacaagt gttttatgtt aaattggctg gtggtttgaa atgaatcatc ttcacataat    12960

gttttcttta aaaatattgt gaatttaact ctaattcttg ttattctgtg tgataataaa    13020

gaataaacta atttcta                                                   13037


<210>  28
<211>  933
<212>  PRT
<213>  Homo sapiens

<400>  28

Met Thr Glu Leu Lys Ala Lys Gly Pro Arg Ala Pro His Val Ala Gly 
1               5                   10                  15      


Gly Pro Pro Ser Pro Glu Val Gly Ser Pro Leu Leu Cys Arg Pro Ala 
            20                  25                  30          


Ala Gly Pro Phe Pro Gly Ser Gln Thr Ser Asp Thr Leu Pro Glu Val 
        35                  40                  45              


Ser Ala Ile Pro Ile Ser Leu Asp Gly Leu Leu Phe Pro Arg Pro Cys 
    50                  55                  60                  


Gln Gly Gln Asp Pro Ser Asp Glu Lys Thr Gln Asp Gln Gln Ser Leu 
65                  70                  75                  80  


Ser Asp Val Glu Gly Ala Tyr Ser Arg Ala Glu Ala Thr Arg Gly Ala 
                85                  90                  95      


Gly Gly Ser Ser Ser Ser Pro Pro Glu Lys Asp Ser Gly Leu Leu Asp 
            100                 105                 110         


Ser Val Leu Asp Thr Leu Leu Ala Pro Ser Gly Pro Gly Gln Ser Gln 
        115                 120                 125             


Pro Ser Pro Pro Ala Cys Glu Val Thr Ser Ser Trp Cys Leu Phe Gly 
    130                 135                 140                 


Pro Glu Leu Pro Glu Asp Pro Pro Ala Ala Pro Ala Thr Gln Arg Val 
145                 150                 155                 160 


Leu Ser Pro Leu Met Ser Arg Ser Gly Cys Lys Val Gly Asp Ser Ser 
                165                 170                 175     


Gly Thr Ala Ala Ala His Lys Val Leu Pro Arg Gly Leu Ser Pro Ala 
            180                 185                 190         


Arg Gln Leu Leu Leu Pro Ala Ser Glu Ser Pro His Trp Ser Gly Ala 
        195                 200                 205             


Pro Val Lys Pro Ser Pro Gln Ala Ala Ala Val Glu Val Glu Glu Glu 
    210                 215                 220                 


Asp Gly Ser Glu Ser Glu Glu Ser Ala Gly Pro Leu Leu Lys Gly Lys 
225                 230                 235                 240 


Pro Arg Ala Leu Gly Gly Ala Ala Ala Gly Gly Gly Ala Ala Ala Val 
                245                 250                 255     


Pro Pro Gly Ala Ala Ala Gly Gly Val Ala Leu Val Pro Lys Glu Asp 
            260                 265                 270         


Ser Arg Phe Ser Ala Pro Arg Val Ala Leu Val Glu Gln Asp Ala Pro 
        275                 280                 285             


Met Ala Pro Gly Arg Ser Pro Leu Ala Thr Thr Val Met Asp Phe Ile 
    290                 295                 300                 


His Val Pro Ile Leu Pro Leu Asn His Ala Leu Leu Ala Ala Arg Thr 
305                 310                 315                 320 


Arg Gln Leu Leu Glu Asp Glu Ser Tyr Asp Gly Gly Ala Gly Ala Ala 
                325                 330                 335     


Ser Ala Phe Ala Pro Pro Arg Ser Ser Pro Cys Ala Ser Ser Thr Pro 
            340                 345                 350         


Val Ala Val Gly Asp Phe Pro Asp Cys Ala Tyr Pro Pro Asp Ala Glu 
        355                 360                 365             


Pro Lys Asp Asp Ala Tyr Pro Leu Tyr Ser Asp Phe Gln Pro Pro Ala 
    370                 375                 380                 


Leu Lys Ile Lys Glu Glu Glu Glu Gly Ala Glu Ala Ser Ala Arg Ser 
385                 390                 395                 400 


Pro Arg Ser Tyr Leu Val Ala Gly Ala Asn Pro Ala Ala Phe Pro Asp 
                405                 410                 415     


Phe Pro Leu Gly Pro Pro Pro Pro Leu Pro Pro Arg Ala Thr Pro Ser 
            420                 425                 430         


Arg Pro Gly Glu Ala Ala Val Thr Ala Ala Pro Ala Ser Ala Ser Val 
        435                 440                 445             


Ser Ser Ala Ser Ser Ser Gly Ser Thr Leu Glu Cys Ile Leu Tyr Lys 
    450                 455                 460                 


Ala Glu Gly Ala Pro Pro Gln Gln Gly Pro Phe Ala Pro Pro Pro Cys 
465                 470                 475                 480 


Lys Ala Pro Gly Ala Ser Gly Cys Leu Leu Pro Arg Asp Gly Leu Pro 
                485                 490                 495     


Ser Thr Ser Ala Ser Ala Ala Ala Ala Gly Ala Ala Pro Ala Leu Tyr 
            500                 505                 510         


Pro Ala Leu Gly Leu Asn Gly Leu Pro Gln Leu Gly Tyr Gln Ala Ala 
        515                 520                 525             


Val Leu Lys Glu Gly Leu Pro Gln Val Tyr Pro Pro Tyr Leu Asn Tyr 
    530                 535                 540                 


Leu Arg Pro Asp Ser Glu Ala Ser Gln Ser Pro Gln Tyr Ser Phe Glu 
545                 550                 555                 560 


Ser Leu Pro Gln Lys Ile Cys Leu Ile Cys Gly Asp Glu Ala Ser Gly 
                565                 570                 575     


Cys His Tyr Gly Val Leu Thr Cys Gly Ser Cys Lys Val Phe Phe Lys 
            580                 585                 590         


Arg Ala Met Glu Gly Gln His Asn Tyr Leu Cys Ala Gly Arg Asn Asp 
        595                 600                 605             


Cys Ile Val Asp Lys Ile Arg Arg Lys Asn Cys Pro Ala Cys Arg Leu 
    610                 615                 620                 


Arg Lys Cys Cys Gln Ala Gly Met Val Leu Gly Gly Arg Lys Phe Lys 
625                 630                 635                 640 


Lys Phe Asn Lys Val Arg Val Val Arg Ala Leu Asp Ala Val Ala Leu 
                645                 650                 655     


Pro Gln Pro Val Gly Val Pro Asn Glu Ser Gln Ala Leu Ser Gln Arg 
            660                 665                 670         


Phe Thr Phe Ser Pro Gly Gln Asp Ile Gln Leu Ile Pro Pro Leu Ile 
        675                 680                 685             


Asn Leu Leu Met Ser Ile Glu Pro Asp Val Ile Tyr Ala Gly His Asp 
    690                 695                 700                 


Asn Thr Lys Pro Asp Thr Ser Ser Ser Leu Leu Thr Ser Leu Asn Gln 
705                 710                 715                 720 


Leu Gly Glu Arg Gln Leu Leu Ser Val Val Lys Trp Ser Lys Ser Leu 
                725                 730                 735     


Pro Gly Phe Arg Asn Leu His Ile Asp Asp Gln Ile Thr Leu Ile Gln 
            740                 745                 750         


Tyr Ser Trp Met Ser Leu Met Val Phe Gly Leu Gly Trp Arg Ser Tyr 
        755                 760                 765             


Lys His Val Ser Gly Gln Met Leu Tyr Phe Ala Pro Asp Leu Ile Leu 
    770                 775                 780                 


Asn Glu Gln Arg Met Lys Glu Ser Ser Phe Tyr Ser Leu Cys Leu Thr 
785                 790                 795                 800 


Met Trp Gln Ile Pro Gln Glu Phe Val Lys Leu Gln Val Ser Gln Glu 
                805                 810                 815     


Glu Phe Leu Cys Met Lys Val Leu Leu Leu Leu Asn Thr Ile Pro Leu 
            820                 825                 830         


Glu Gly Leu Arg Ser Gln Thr Gln Phe Glu Glu Met Arg Ser Ser Tyr 
        835                 840                 845             


Ile Arg Glu Leu Ile Lys Ala Ile Gly Leu Arg Gln Lys Gly Val Val 
    850                 855                 860                 


Ser Ser Ser Gln Arg Phe Tyr Gln Leu Thr Lys Leu Leu Asp Asn Leu 
865                 870                 875                 880 


His Asp Leu Val Lys Gln Leu His Leu Tyr Cys Leu Asn Thr Phe Ile 
                885                 890                 895     


Gln Ser Arg Ala Leu Ser Val Glu Phe Pro Glu Met Met Ser Glu Val 
            900                 905                 910         


Ile Ala Ala Gln Leu Pro Lys Ile Leu Ala Gly Met Val Lys Pro Leu 
        915                 920                 925             


Leu Phe His Lys Lys 
    930             


<210>  29
<211>  1762
<212>  DNA
<213>  Homo sapiens

<400>  29
cggccgaggg cggggcaggg aggcagcatg ctaaaccggg tgcgctcggc cgtggcgcac       60

ctggtgagct ccgggggcgc tccgcctccg cgccccaaat ccccggacct gcccaacgcc      120

gcctcggcgc cgcccgccgc cgctccagaa gcgcccagga gccctcccgc gaaggctggg      180

agcgggagcg cgacgcccgc gaaggctgtt gaggctcgag cgagcttctc cagaccgacc      240

tttctgcagc tgagccccgg ggggctgcga cgcgccgatg accacgcggg ccgggctgtg      300

caaagccccc cggacacggg ccgccgcctg ccctggagca caggctacgc cgaggtcatc      360

aatgctggca agagtcggca caatgaggac caggcttgct gtgaagtggt gtatgtggaa      420

ggtcggagga gtgttacagg agtacctagg gagcctagcc gaggccaggg actctgcttc      480

tactactggg gcctatttga tgggcatgca gggggcggag ctgctgaaat ggcctcacgg      540

ctcctgcatc gccatatccg agagcagcta aaggacctgg tagagatact tcaggaccct      600

tcgccaccac ccctctgcct cccaaccact ccggggaccc cagattcctc cgatccctct      660

cacttgcttg gccctcagtc ctgctggtct tcacagaagg aagtgagcca cgagagcctg      720

gtagtggggg ccgttgagaa tgccttccag ctcatggatg agcagatggc ccgggagcgg      780

cgtggccacc aagtggaggg gggctgctgt gcactggttg tgatctacct gctaggcaag      840

gtgtacgtgg ccaatgcagg cgatagcagg gccatcattg tccggaatgg tgaaatcatt      900

ccaatgtccc gggagtttac cccggagact gagcgccagc gtcttcagct gcttggcttc      960

ctgaaaccag agctgctagg cagtgaattc acccaccttg agttcccccg cagagttctg     1020

cccaaggagc tggggcagag gatgttgtac cgggaccaga acatgaccgg ctgggcctac     1080

aaaaagatcg agctggagga tctcaggttt cctctggtct gtggggaggg caaaaaggct     1140

cgggtgatgg ccaccattgg ggtgacccga ggcttgggag accacagcct taaggtctgc     1200

agttccaccc tgcccatcaa gccctttctc tcctgcttcc ctgaggtacg agtgtatgac     1260

ctgacacaat atgagcactg cccagatgat gtgctagtcc tgggaacaga tggcctgtgg     1320

gatgtcacta ctgactgtga ggtagctgcc actgtggaca gggtgctgtc ggcctatgag     1380

cctaatgacc acagcaggta tacagctctg gcccaagctc tggtcctggg ggcccggggt     1440

accccccgag accgtggctg gcgtctcccc aacaacaagc tgggttccgg ggatgacatc     1500

tctgtcttcg tcatccccct gggagggcca ggcagttact cctgaggggc tgaacaccat     1560

ccctcccact agcctctcca tacttactcc tctcacagcc caaattctga agttgtctcc     1620

ctgacccttc tttagtggca acttaactga agaagggatg tccgctatat ccaaaattac     1680

agctattggc aaataaacga gatggataaa ggtgaaaaaa aaaaaaaaaa aaaaaaaaaa     1740

aaaaaaaaaa aaaaaaaaaa aa                                              1762


<210>  30
<211>  505
<212>  PRT
<213>  Homo sapiens

<400>  30

Met Leu Asn Arg Val Arg Ser Ala Val Ala His Leu Val Ser Ser Gly 
1               5                   10                  15      


Gly Ala Pro Pro Pro Arg Pro Lys Ser Pro Asp Leu Pro Asn Ala Ala 
            20                  25                  30          


Ser Ala Pro Pro Ala Ala Ala Pro Glu Ala Pro Arg Ser Pro Pro Ala 
        35                  40                  45              


Lys Ala Gly Ser Gly Ser Ala Thr Pro Ala Lys Ala Val Glu Ala Arg 
    50                  55                  60                  


Ala Ser Phe Ser Arg Pro Thr Phe Leu Gln Leu Ser Pro Gly Gly Leu 
65                  70                  75                  80  


Arg Arg Ala Asp Asp His Ala Gly Arg Ala Val Gln Ser Pro Pro Asp 
                85                  90                  95      


Thr Gly Arg Arg Leu Pro Trp Ser Thr Gly Tyr Ala Glu Val Ile Asn 
            100                 105                 110         


Ala Gly Lys Ser Arg His Asn Glu Asp Gln Ala Cys Cys Glu Val Val 
        115                 120                 125             


Tyr Val Glu Gly Arg Arg Ser Val Thr Gly Val Pro Arg Glu Pro Ser 
    130                 135                 140                 


Arg Gly Gln Gly Leu Cys Phe Tyr Tyr Trp Gly Leu Phe Asp Gly His 
145                 150                 155                 160 


Ala Gly Gly Gly Ala Ala Glu Met Ala Ser Arg Leu Leu His Arg His 
                165                 170                 175     


Ile Arg Glu Gln Leu Lys Asp Leu Val Glu Ile Leu Gln Asp Pro Ser 
            180                 185                 190         


Pro Pro Pro Leu Cys Leu Pro Thr Thr Pro Gly Thr Pro Asp Ser Ser 
        195                 200                 205             


Asp Pro Ser His Leu Leu Gly Pro Gln Ser Cys Trp Ser Ser Gln Lys 
    210                 215                 220                 


Glu Val Ser His Glu Ser Leu Val Val Gly Ala Val Glu Asn Ala Phe 
225                 230                 235                 240 


Gln Leu Met Asp Glu Gln Met Ala Arg Glu Arg Arg Gly His Gln Val 
                245                 250                 255     


Glu Gly Gly Cys Cys Ala Leu Val Val Ile Tyr Leu Leu Gly Lys Val 
            260                 265                 270         


Tyr Val Ala Asn Ala Gly Asp Ser Arg Ala Ile Ile Val Arg Asn Gly 
        275                 280                 285             


Glu Ile Ile Pro Met Ser Arg Glu Phe Thr Pro Glu Thr Glu Arg Gln 
    290                 295                 300                 


Arg Leu Gln Leu Leu Gly Phe Leu Lys Pro Glu Leu Leu Gly Ser Glu 
305                 310                 315                 320 


Phe Thr His Leu Glu Phe Pro Arg Arg Val Leu Pro Lys Glu Leu Gly 
                325                 330                 335     


Gln Arg Met Leu Tyr Arg Asp Gln Asn Met Thr Gly Trp Ala Tyr Lys 
            340                 345                 350         


Lys Ile Glu Leu Glu Asp Leu Arg Phe Pro Leu Val Cys Gly Glu Gly 
        355                 360                 365             


Lys Lys Ala Arg Val Met Ala Thr Ile Gly Val Thr Arg Gly Leu Gly 
    370                 375                 380                 


Asp His Ser Leu Lys Val Cys Ser Ser Thr Leu Pro Ile Lys Pro Phe 
385                 390                 395                 400 


Leu Ser Cys Phe Pro Glu Val Arg Val Tyr Asp Leu Thr Gln Tyr Glu 
                405                 410                 415     


His Cys Pro Asp Asp Val Leu Val Leu Gly Thr Asp Gly Leu Trp Asp 
            420                 425                 430         


Val Thr Thr Asp Cys Glu Val Ala Ala Thr Val Asp Arg Val Leu Ser 
        435                 440                 445             


Ala Tyr Glu Pro Asn Asp His Ser Arg Tyr Thr Ala Leu Ala Gln Ala 
    450                 455                 460                 


Leu Val Leu Gly Ala Arg Gly Thr Pro Arg Asp Arg Gly Trp Arg Leu 
465                 470                 475                 480 


Pro Asn Asn Lys Leu Gly Ser Gly Asp Asp Ile Ser Val Phe Val Ile 
                485                 490                 495     


Pro Leu Gly Gly Pro Gly Ser Tyr Ser 
            500                 505 


<210>  31
<211>  3468
<212>  DNA
<213>  Homo sapiens

<400>  31
attgtgccct accagagagg acagatgggc accgcctcca gtggcaatgc taattcaccc       60

aagaggcctt cccagctctt ctcacagaag gaagataaac tccacatatt tctatatcct      120

gctggatgac attgtcctta cccattctct cttcctcccg acggagaaat ttctgcagga      180

gctacaccag tactttgttc gggcaggagg catggagggc cctgaagggc tgggccggaa      240

gcaagcctgt ctagccatgc ttctccattt cttggacacc taccaggggc tgcttcaaga      300

ggaagagggg gccggccaca tcatcaagga tctatacctg ctaattatga aggacgagtc      360

cctttaccag ggcctccgag aggacactct gaggctgcac cagctggtgg agacggtgga      420

actaaagatt ccagaggaga accagccacc cagcaagcag gtgaagccac tcttccgcca      480

cttccgccgg atagactcct gtctgcagac ccgggtggcc ttccggggct ctgatgagat      540

cttctgccgt gtatacatgc ctgaccactc ttatgtgacc atacgcagcc gcctttcagc      600

atctgtgcag gacattctgg gctctgtgac ggagaaactt caatattcag aggagcccgc      660

ggggcgtgag gattccctca tcctggtagc tgtgtcctcc tctggagaga aggtccttct      720

ccagcccact gaggactgtg ttttcaccgc actgggcatc aacagccacc tgtttgcctg      780

tactcgggac agctatgagg ctctggtgcc cctccccgag gagatccagg tctcccctgg      840

agacacagag atccaccgag tggagcctga ggacgttgcc aaccacctaa ctgccttcca      900

ctgggagctg ttccgatgtg tgcatgagct ggagttcgtg gactacgtgt tccacgggga      960

gcgcggccgc cgggagacgg ccaacttgga gctgctgctg cagcgctgca gcgaggtcac     1020

gcactgggtg gccaccgaag tgctgctctg cgaggccccg ggcaagcgcg cgcagctgct     1080

caagaagttc atcaagatcg cggccctctg caagcagaac caggacctgc tgtctttcta     1140

cgccgtggtc atggggctgg acaacgccgc tgtcagccgc cttcgactca cctgggagaa     1200

gctgccaggg aaattcaaga acttgtttcg caaatttgag aacctgacgg acccctgcag     1260

gaaccacaaa agctaccgag aagtgatctc caaaatgaag ccccctgtga ttcccttcgt     1320

gcctctgatc ctcaaagacc tgactttcct gcacgaaggg agtaagaccc ttgtagatgg     1380

tttggtgaac atcgagaagc tgcattcagt ggccgaaaaa gtgaggacaa tccgcaaata     1440

ccggagccgg cccctttgcc tggacatgga ggcatccccc aatcacctgc agaccaaggc     1500

ctatgtgcgc cagtttcagg tcatcgacaa ccagaacctc ctcttcgagc tctcctacaa     1560

gctggaggca aacagtcagt gagagtggag gctccagtca gacccgccag atccttgggc     1620

acctggcact caagcacttt gcacgatgtc tcaaccaaca tctgacatct ttcccgtgga     1680

gcaacttcct gctccacggg aaagaggtcg atggatttac ccctggaccc ataagtctgt     1740

tcatcctgct gaagtcccct ccccattgct ccttcaagcc aaaactacac tttgctggtt     1800

cctgtcccct ctgagaaagg ggatagaaag ctccttcctc tatgtcctcc catcgagatc     1860

tgttctgggg atggagcttc caacttcctc ttgcagcagg aaagaatgct gctcaccctt     1920

ctgtcttgca gagtgggatt gtgggaggga ttggcagcct tcttctccac cacctgtcca     1980

gcttcttcct ggtcagggct gggaccccca ggaatattat gttgccgtgt gtgtgtgtgt     2040

gtgtgtgtgt gtgtgtgtgt gtgtgtgtgt gtgtgtgtgt gtgtcttctt ttagggagca     2100

ggagtgcatc tggtaattga gggtggatgt tgtgtgtgct ggggaggggt ccttctgttt     2160

ggtgctaccc ttgtctactc tgcccctgga tggtgcgggg tgctttctcc acccccacac     2220

tccctgctca gctcctcgtg ctgccctgca tgcccaggct tgtgagccaa gctgcttttt     2280

ggggcaggga gtagcagcag gtgggagggg ttacccatca gcccttgcaa gtcccccact     2340

caggcctctg gaaggtccag ggatgggctc tgatgagagg gtaaaagatg ctcagggaaa     2400

cacaggcctc agctgcctag aggaccctcc ccctgccttg cagtgggctc gggtagagca     2460

gtatcaggag ctagggttgt ctgctgccca cactcctgct ttttgggata tctaactgct     2520

aaggagggag ttgacatccc ccttctggct catgtgtctg acaccaacaa catggtctct     2580

gtccctctct ctttgactct ccctttgtcc tccccataga gctggggtgg ggtggatccc     2640

tatacctggg gcaggcagcc ccaaagtggg ggagggggat ggcagagact gtaaaggcgc     2700

cactggactc tggcaaggcc tttattacct ttactcccct ccctctccca tcaccagcct     2760

caaggcctga ggggtgcagg ggctcctggc agctactggg tgaggtttcc tggcacagac     2820

tcacccttct ttctggcacc acctctttcc cttttgaaga gacagcaaca gccgtagcaa     2880

aagcagctgc tgctcctgct atgagggtgt atatattttt tacccaaagc tctggaattg     2940

tacatttatt ttttaaaact caaagaggga aagagccttg tatcatatgt gaacattgta     3000

tcataggtaa tgttgtacag acccttttat acagtgatct gtcttgttcc tgcagcaaaa     3060

atcctctatg gacataggag gtgctgtgtc ccatgccctc ttgccctgac agtgtcccat     3120

gggccccctt ctgctccctg ccccctccct gctactgctg atgcactctc ctctccctgc     3180

agcccctggc ttcccagcct tcctcctgac cccttccaac agccttggaa ctccagctgc     3240

caccaccctc tgggtcggac actgggaccc actggcccag tcttggctgc tgcttacccc     3300

tagccttgat gcctgcccag ggacccccag ccccctcccg ttgccctgca gctttaacag     3360

agtgaaccat gtgtattgta caggcgcggt tgtcattgca gaaaccgctg ggtggagaag     3420

aagccgataa agtctatgaa tcaacctgcc aaaaaaaaaa aaaaaaaa                  3468


<210>  32
<211>  662
<212>  PRT
<213>  Homo sapiens

<400>  32

Met Lys Pro Leu Glu Lys Phe Leu Lys Lys Gln Thr Ser Gln Leu Ala 
1               5                   10                  15      


Gly Arg Thr Val Ala Gly Gly Pro Gly Gly Gly Leu Gly Ser Cys Gly 
            20                  25                  30          


Gly Pro Gly Gly Gly Gly Gly Pro Gly Gly Gly Gly Gly Pro Ala Gly 
        35                  40                  45              


Gly Gln Arg Ser Leu Gln Arg Arg Gln Ser Val Ser Arg Leu Leu Leu 
    50                  55                  60                  


Pro Ala Phe Leu Arg Glu Pro Pro Ala Glu Pro Gly Leu Glu Pro Pro 
65                  70                  75                  80  


Val Pro Glu Glu Gly Gly Glu Pro Ala Gly Val Ala Glu Glu Pro Gly 
                85                  90                  95      


Ser Gly Gly Pro Cys Trp Leu Gln Leu Glu Glu Val Pro Gly Pro Gly 
            100                 105                 110         


Pro Leu Gly Gly Gly Gly Pro Leu Arg Ser Pro Ser Ser Tyr Ser Ser 
        115                 120                 125             


Asp Glu Leu Ser Pro Gly Glu Pro Leu Thr Ser Pro Pro Trp Ala Pro 
    130                 135                 140                 


Leu Gly Ala Pro Glu Arg Pro Glu His Leu Leu Asn Arg Val Leu Glu 
145                 150                 155                 160 


Arg Leu Ala Gly Gly Ala Thr Arg Asp Ser Ala Ala Ser Asp Ile Leu 
                165                 170                 175     


Leu Asp Asp Ile Val Leu Thr His Ser Leu Phe Leu Pro Thr Glu Lys 
            180                 185                 190         


Phe Leu Gln Glu Leu His Gln Tyr Phe Val Arg Ala Gly Gly Met Glu 
        195                 200                 205             


Gly Pro Glu Gly Leu Gly Arg Lys Gln Ala Cys Leu Ala Met Leu Leu 
    210                 215                 220                 


His Phe Leu Asp Thr Tyr Gln Gly Leu Leu Gln Glu Glu Glu Gly Ala 
225                 230                 235                 240 


Gly His Ile Ile Lys Asp Leu Tyr Leu Leu Ile Met Lys Asp Glu Ser 
                245                 250                 255     


Leu Tyr Gln Gly Leu Arg Glu Asp Thr Leu Arg Leu His Gln Leu Val 
            260                 265                 270         


Glu Thr Val Glu Leu Lys Ile Pro Glu Glu Asn Gln Pro Pro Ser Lys 
        275                 280                 285             


Gln Val Lys Pro Leu Phe Arg His Phe Arg Arg Ile Asp Ser Cys Leu 
    290                 295                 300                 


Gln Thr Arg Val Ala Phe Arg Gly Ser Asp Glu Ile Phe Cys Arg Val 
305                 310                 315                 320 


Tyr Met Pro Asp His Ser Tyr Val Thr Ile Arg Ser Arg Leu Ser Ala 
                325                 330                 335     


Ser Val Gln Asp Ile Leu Gly Ser Val Thr Glu Lys Leu Gln Tyr Ser 
            340                 345                 350         


Glu Glu Pro Ala Gly Arg Glu Asp Ser Leu Ile Leu Val Ala Val Ser 
        355                 360                 365             


Ser Ser Gly Glu Lys Val Leu Leu Gln Pro Thr Glu Asp Cys Val Phe 
    370                 375                 380                 


Thr Ala Leu Gly Ile Asn Ser His Leu Phe Ala Cys Thr Arg Asp Ser 
385                 390                 395                 400 


Tyr Glu Ala Leu Val Pro Leu Pro Glu Glu Ile Gln Val Ser Pro Gly 
                405                 410                 415     


Asp Thr Glu Ile His Arg Val Glu Pro Glu Asp Val Ala Asn His Leu 
            420                 425                 430         


Thr Ala Phe His Trp Glu Leu Phe Arg Cys Val His Glu Leu Glu Phe 
        435                 440                 445             


Val Asp Tyr Val Phe His Gly Glu Arg Gly Arg Arg Glu Thr Ala Asn 
    450                 455                 460                 


Leu Glu Leu Leu Leu Gln Arg Cys Ser Glu Val Thr His Trp Val Ala 
465                 470                 475                 480 


Thr Glu Val Leu Leu Cys Glu Ala Pro Gly Lys Arg Ala Gln Leu Leu 
                485                 490                 495     


Lys Lys Phe Ile Lys Ile Ala Ala Leu Cys Lys Gln Asn Gln Asp Leu 
            500                 505                 510         


Leu Ser Phe Tyr Ala Val Val Met Gly Leu Asp Asn Ala Ala Val Ser 
        515                 520                 525             


Arg Leu Arg Leu Thr Trp Glu Lys Leu Pro Gly Lys Phe Lys Asn Leu 
    530                 535                 540                 


Phe Arg Lys Phe Glu Asn Leu Thr Asp Pro Cys Arg Asn His Lys Ser 
545                 550                 555                 560 


Tyr Arg Glu Val Ile Ser Lys Met Lys Pro Pro Val Ile Pro Phe Val 
                565                 570                 575     


Pro Leu Ile Leu Lys Asp Leu Thr Phe Leu His Glu Gly Ser Lys Thr 
            580                 585                 590         


Leu Val Asp Gly Leu Val Asn Ile Glu Lys Leu His Ser Val Ala Glu 
        595                 600                 605             


Lys Val Arg Thr Ile Arg Lys Tyr Arg Ser Arg Pro Leu Cys Leu Asp 
    610                 615                 620                 


Met Glu Ala Ser Pro Asn His Leu Gln Thr Lys Ala Tyr Val Arg Gln 
625                 630                 635                 640 


Phe Gln Val Ile Asp Asn Gln Asn Leu Leu Phe Glu Leu Ser Tyr Lys 
                645                 650                 655     


Leu Glu Ala Asn Ser Gln 
            660         


<210>  33
<211>  2467
<212>  DNA
<213>  Homo sapiens

<400>  33
gaagatgcac acgacccaga aggacacgac gtacaccaag atcttcgtcg gggggctgcc       60

ctaccacacc accgacgcca gcctgcgcaa gtacttcgag gtcttcggcg agatcgagga      120

ggcggtggtc atcaccgacc ggcagacggg caagtcccgg ggctatggat ttgtcaccat      180

ggctgaccgg gctgctgccg aaagggcctg caaggatccc aatcccatca ttgatggcag      240

aaaggccaac gtgaacctgg catacttagg agcaaaacca aggatcatgc aaccaggttt      300

tgcctttggt gttcaacaac ttcatccagc ccttatacaa agacctttcg ggatacctgc      360

ccactatgtc tatccgcagg cttttgtgca gccgggagtg gtcattccac acgtccagcc      420

gacagcagct gccgcctcca ccacccctta cattgattac actggagctg catacgcaca      480

atactcagca gctgctgctg ctgccgccgc cgctgctgcc tatgaccagt acccctatgc      540

agcctctcca gctgctgcag gatatgttac tgctgggggc tatggctacg cagtccagca      600

gccaatcacc gcagcggcac ctgggacagc tgccgccgcc gctgcagcag ctgctgccgc      660

tgcagcattt ggccagtacc agcctcagca gctgcagaca gaccgaatgc aatagaccag      720

ccatctgatc aaagttgaat tgttttctct ttccctccca attttccaat ttttagtagc      780

taataagaga gttaacattg acttaacagc tttaaaaaaa aaaacagcca tgctattgtg      840

aagcagagtt attatttttt ttatactcca ggtagtgttc tagatgagaa agaggtaaga      900

atgaggggaa tgggcacaat tttggaaatc aatcccaaag agcctgagta aatgaaaggc      960

cactacgaaa tgacgccagg agtaacaacg gaacttcact tttgtaacgg gatttttatt     1020

tttgctcttt ttatagtatc agggaagcaa actgcctttt acaagttaga aaatgctgtt     1080

tgaatctagt tgaaccaggg aatacagagc gagcaatatg tagcttgaat tacatttaaa     1140

agcagatttt ttacaaacaa aatggcgaaa gcactgattg tcatttttag cagtcactta     1200

aggcctatag aacttttttc aagtcggaag gtcctgttct tactatctca aaaatgggca     1260

tcgaacaatc aatctaggag cgtggcagtg ggtaaaatgg tggacaggca ccaaagctat     1320

tttctcatct gtcctgtgga tgagtggaac tgtggaacaa gtgatgtgga attaatgggt     1380

gcaacagctg tacagacaat caataacaca cacagttctg gaaagaacac atcacttgtg     1440

cttgtttgat gagcttgtca cattctaatc cctctcccca tcctgtttca attttgggaa     1500

acttgtatct gctggtgtca gcaattctga ttctgaaata ggatcaggct tttactacaa     1560

cagccttctc tttctattta ttgtgtcgac tcgtggctta tgaataaagg caggcaaagt     1620

ttgcagaact gtcttaagga catttatttt ttttcccttt ttaagtaatt ttacacttta     1680

gtatctattt cagagtcata tttaaaacta tttattagtg actacagtac atgagacaac     1740

aaggttactg agattacaat tcttcaaagg ttaatgataa tgtggtttat actgtgcctt     1800

aatagtaatg ctatttaaga tatttatttt taagttttac tatgctgcac tctaaagaaa     1860

ggaactttag atgtgacact gtaaaattat gtattcatct catggcataa attatttagt     1920

aagtctagat gtagcgtatt aaatattaac ctattcaact aaagatgttg acttggattt     1980

atttaaattc atatgtgcac tgtataagag agtactctta cattaacaca ttttagttta     2040

gtttttagat ttttttttaa acgatatatt gctagtttca tgcttcctcc tctgattttg     2100

cctgtgtaga tttcatttat tggtaattca ttagtttaac actattatgt agtttttaaa     2160

tgctgcttta catttttctt ctgaaactgc aatacttgca atttttattc ttaaactaaa     2220

ttgaatacta ttttacactg tattggattt ttatacttga acaatttcat acaagggaag     2280

acaggttagc atttttatgg actttctcca ttatcactgg atttacttta agtattccca     2340

tactagacag tgttatgtaa tgtagacatg actctcctgt gcaaattatt tattcgttgt     2400

gtatattgct ttataacatt tcagatcttc taatctattc acttgtatta aatataattt     2460

ttaaaaa                                                               2467


<210>  34
<211>  236
<212>  PRT
<213>  Homo sapiens

<400>  34

Met His Thr Thr Gln Lys Asp Thr Thr Tyr Thr Lys Ile Phe Val Gly 
1               5                   10                  15      


Gly Leu Pro Tyr His Thr Thr Asp Ala Ser Leu Arg Lys Tyr Phe Glu 
            20                  25                  30          


Val Phe Gly Glu Ile Glu Glu Ala Val Val Ile Thr Asp Arg Gln Thr 
        35                  40                  45              


Gly Lys Ser Arg Gly Tyr Gly Phe Val Thr Met Ala Asp Arg Ala Ala 
    50                  55                  60                  


Ala Glu Arg Ala Cys Lys Asp Pro Asn Pro Ile Ile Asp Gly Arg Lys 
65                  70                  75                  80  


Ala Asn Val Asn Leu Ala Tyr Leu Gly Ala Lys Pro Arg Ile Met Gln 
                85                  90                  95      


Pro Gly Phe Ala Phe Gly Val Gln Gln Leu His Pro Ala Leu Ile Gln 
            100                 105                 110         


Arg Pro Phe Gly Ile Pro Ala His Tyr Val Tyr Pro Gln Ala Phe Val 
        115                 120                 125             


Gln Pro Gly Val Val Ile Pro His Val Gln Pro Thr Ala Ala Ala Ala 
    130                 135                 140                 


Ser Thr Thr Pro Tyr Ile Asp Tyr Thr Gly Ala Ala Tyr Ala Gln Tyr 
145                 150                 155                 160 


Ser Ala Ala Ala Ala Ala Ala Ala Ala Ala Ala Ala Tyr Asp Gln Tyr 
                165                 170                 175     


Pro Tyr Ala Ala Ser Pro Ala Ala Ala Gly Tyr Val Thr Ala Gly Gly 
            180                 185                 190         


Tyr Gly Tyr Ala Val Gln Gln Pro Ile Thr Ala Ala Ala Pro Gly Thr 
        195                 200                 205             


Ala Ala Ala Ala Ala Ala Ala Ala Ala Ala Ala Ala Ala Phe Gly Gln 
    210                 215                 220                 


Tyr Gln Pro Gln Gln Leu Gln Thr Asp Arg Met Gln 
225                 230                 235     


<210>  35
<211>  2264
<212>  DNA
<213>  Homo sapiens

<400>  35
gcagtccctc cgccgctagt cggagcgagc gcgagtgagg agacccccgc cgggccactg       60

gcacttgctt ctgcggcgag tcccacccac gaccgcagcc cagcaactcg caaacgcaac      120

ctgaagcctg ggctgcgcag tgtgggaggg cttcgcgatc ttgggggacc cattccgaac      180

ttgcagagga ccgtagctct cctggcctgg agagtgtgaa caggattgtg gactcttcca      240

agattcacaa tgatatggtg aatccaaaga ctggaaccaa aaagatttac tcagtgcttt      300

agttttaaca acagtaaatt gtctaccaac acccatcatg gctaaaagtg cggaggtcaa      360

actggcaata tttgggagag caggcgtggg caagtcagct cttgtagtga gatttctgac      420

caaacggttc atctgggaat atgatcccac cctcgaatca acctaccgac accaagcaac      480

catcgatgat gaagttgttt ccatggagat actagacact gctggtcagg aagataccat      540

tcagagggag gggcacatgc gatgggggga aggctttgtg ctggtctacg acattactga      600

ccgaggaagt tttgaggaag tgctgccact taagaacatc ctagatgaga tcaaaaagcc      660

caagaatgtg actctcatct tggttggaaa caaagctgac ttggaccact ccaggcaggt      720

tagcacagaa gaaggagaga agctggccac agaattggct tgtgcttttt acgagtgctc      780

tgcctgcact ggagaaggga acatcacaga gatattctat gaattgtgtc gagaggtgcg      840

tcgccggagg atggtgcagg gcaagacgag gcgacgcagc tccaccacgc atgtcaagca      900

agccattaac aagatgctca ccaaaatcag tagttaggca gcccagctga ggtggaccaa      960

ctaattggaa acactcttcc ccttctgttc ccctttcaaa aataaaacaa aatattgcat     1020

tctttgtttg gattctgaga aatgtctggg cttcccattg tttctggcct ctaataggtt     1080

gggaagtttt agcgtgtttt atgcaatttc agtgctaaca atttcttcct ttcctgcttg     1140

aataagatac actctaatgg catttgaaca tgtaatcacc agagattctg aaatgactgg     1200

tttatgttaa gctattttta ggcatcttca ccttgcttta agtaggttga agtttttgca     1260

aaggcattta aaaattcaat ttcttgtcag atactacaaa taattttctt aaaagtctaa     1320

gatagcagaa aatacagtaa aaacacagga gaagaagctg agctattgga acaggaaata     1380

gaaggaactc tagtttctgt ttgaagtgag gattttctga attatctaat atcatctagg     1440

ttttctttaa aattttattt tgttcttcag ttcaagcatc ttctcactaa tgtttttcac     1500

tataacagag aattcatttc aatttgagtt ggttctctca atgatctatt gatcattaca     1560

ccctaactct ccttccttgg ctcaaacaat attttcccta taacaaaggc aataggacac     1620

aaaattcaca tcctgctggg ccttttttca tcaagtcagg gtgatataaa aacattggaa     1680

gtcttttcac caaaccctga ctttattgaa tgctagtaga agatgtagaa ttagagacat     1740

ctgatttgtt tatcacctta gcagaaaaac cacagtccaa aagacaagca aattaagaat     1800

ggagcttaac catgcctcca ttgggaagtc tagactttga gccaggtaca gtaagaaaaa     1860

ttagcctctg attcattaag tttgccacat gacttatttt gatattttgg atacattaac     1920

tcacttagga gaattcagaa aagaatgggt gattaaagtt cattacagct gaataaatgt     1980

gtctaaaaca gactcttgta ttctgaaagt acagtctaca actgataaaa ccttatgatt     2040

cttttctccc ccattatgcc cctatatata tcaagatttg ggtactttat tttagtagaa     2100

aatatatatc ttttacatat gtatgtattt ataaatgcat agatatatgt ataaaaattt     2160

gtaagcgtta gcggcattaa ttcaccaatg catttggaca acttgatgta actgacttta     2220

ttttatgtga ctataataaa aagcataatt ttctcattct gtca                      2264


<210>  36
<211>  199
<212>  PRT
<213>  Homo sapiens

<400>  36

Met Ala Lys Ser Ala Glu Val Lys Leu Ala Ile Phe Gly Arg Ala Gly 
1               5                   10                  15      


Val Gly Lys Ser Ala Leu Val Val Arg Phe Leu Thr Lys Arg Phe Ile 
            20                  25                  30          


Trp Glu Tyr Asp Pro Thr Leu Glu Ser Thr Tyr Arg His Gln Ala Thr 
        35                  40                  45              


Ile Asp Asp Glu Val Val Ser Met Glu Ile Leu Asp Thr Ala Gly Gln 
    50                  55                  60                  


Glu Asp Thr Ile Gln Arg Glu Gly His Met Arg Trp Gly Glu Gly Phe 
65                  70                  75                  80  


Val Leu Val Tyr Asp Ile Thr Asp Arg Gly Ser Phe Glu Glu Val Leu 
                85                  90                  95      


Pro Leu Lys Asn Ile Leu Asp Glu Ile Lys Lys Pro Lys Asn Val Thr 
            100                 105                 110         


Leu Ile Leu Val Gly Asn Lys Ala Asp Leu Asp His Ser Arg Gln Val 
        115                 120                 125             


Ser Thr Glu Glu Gly Glu Lys Leu Ala Thr Glu Leu Ala Cys Ala Phe 
    130                 135                 140                 


Tyr Glu Cys Ser Ala Cys Thr Gly Glu Gly Asn Ile Thr Glu Ile Phe 
145                 150                 155                 160 


Tyr Glu Leu Cys Arg Glu Val Arg Arg Arg Arg Met Val Gln Gly Lys 
                165                 170                 175     


Thr Arg Arg Arg Ser Ser Thr Thr His Val Lys Gln Ala Ile Asn Lys 
            180                 185                 190         


Met Leu Thr Lys Ile Ser Ser 
        195                 


<210>  37
<211>  5617
<212>  DNA
<213>  Homo sapiens

<400>  37
agtcccgcga ccgaagcagg gcgcgcagca gcgctgagtg ccccggaacg tgcgtcgcgc       60

ccccagtgtc cgtcgcgtcc gccgcgcccc gggcggggat ggggcggcca gactgagcgc      120

cgcacccgcc atccagaccc gccggcccta gccgcagtcc ctccagccgt ggccccagcg      180

cgcacgggcg atggcgaagg cgacgtccgg tgccgcgggg ctgcgtctgc tgttgctgct      240

gctgctgccg ctgctaggca aagtggcatt gggcctctac ttctcgaggg atgcttactg      300

ggagaagctg tatgtggacc aggcagccgg cacgcccttg ctgtacgtcc atgccctgcg      360

ggacgcccct gaggaggtgc ccagcttccg cctgggccag catctctacg gcacgtaccg      420

cacacggctg catgagaaca actggatctg catccaggag gacaccggcc tcctctacct      480

taaccggagc ctggaccata gctcctggga gaagctcagt gtccgcaacc gcggctttcc      540

cctgctcacc gtctacctca aggtcttcct gtcacccaca tcccttcgtg agggcgagtg      600

ccagtggcca ggctgtgccc gcgtatactt ctccttcttc aacacctcct ttccagcctg      660

cagctccctc aagccccggg agctctgctt cccagagaca aggccctcct tccgcattcg      720

ggagaaccga cccccaggca ccttccacca gttccgcctg ctgcctgtgc agttcttgtg      780

ccccaacatc agcgtggcct acaggctcct ggagggtgag ggtctgccct tccgctgcgc      840

cccggacagc ctggaggtga gcacgcgctg ggccctggac cgcgagcagc gggagaagta      900

cgagctggtg gccgtgtgca ccgtgcacgc cggcgcgcgc gaggaggtgg tgatggtgcc      960

cttcccggtg accgtgtacg acgaggacga ctcggcgccc accttccccg cgggcgtcga     1020

caccgccagc gccgtggtgg agttcaagcg gaaggaggac accgtggtgg ccacgctgcg     1080

tgtcttcgat gcagacgtgg tacctgcatc aggggagctg gtgaggcggt acacaagcac     1140

gctgctcccc ggggacacct gggcccagca gaccttccgg gtggaacact ggcccaacga     1200

gacctcggtc caggccaacg gcagcttcgt gcgggcgacc gtacatgact ataggctggt     1260

tctcaaccgg aacctctcca tctcggagaa ccgcaccatg cagctggcgg tgctggtcaa     1320

tgactcagac ttccagggcc caggagcggg cgtcctcttg ctccacttca acgtgtcggt     1380

gctgccggtc agcctgcacc tgcccagtac ctactccctc tccgtgagca ggagggctcg     1440

ccgatttgcc cagatcggga aagtctgtgt ggaaaactgc caggcattca gtggcatcaa     1500

cgtccagtac aagctgcatt cctctggtgc caactgcagc acgctagggg tggtcacctc     1560

agccgaggac acctcgggga tcctgtttgt gaatgacacc aaggccctgc ggcggcccaa     1620

gtgtgccgaa cttcactaca tggtggtggc caccgaccag cagacctcta ggcaggccca     1680

ggcccagctg cttgtaacag tggaggggtc atatgtggcc gaggaggcgg gctgccccct     1740

gtcctgtgca gtcagcaaga gacggctgga gtgtgaggag tgtggcggcc tgggctcccc     1800

aacaggcagg tgtgagtgga ggcaaggaga tggcaaaggg atcaccagga acttctccac     1860

ctgctctccc agcaccaaga cctgccccga cggccactgc gatgttgtgg agacccaaga     1920

catcaacatt tgccctcagg actgcctccg gggcagcatt gttgggggac acgagcctgg     1980

ggagccccgg gggattaaag ctggctatgg cacctgcaac tgcttccctg aggaggagaa     2040

gtgcttctgc gagcccgaag acatccagga tccactgtgc gacgagctgt gccgcacggt     2100

gatcgcagcc gctgtcctct tctccttcat cgtctcggtg ctgctgtctg ccttctgcat     2160

ccactgctac cacaagtttg cccacaagcc acccatctcc tcagctgaga tgaccttccg     2220

gaggcccgcc caggccttcc cggtcagcta ctcctcttcc ggtgcccgcc ggccctcgct     2280

ggactccatg gagaaccagg tctccgtgga tgccttcaag atcctggagg atccaaagtg     2340

ggaattccct cggaagaact tggttcttgg aaaaactcta ggagaaggcg aatttggaaa     2400

agtggtcaag gcaacggcct tccatctgaa aggcagagca gggtacacca cggtggccgt     2460

gaagatgctg aaagagaacg cctccccgag tgagctgcga gacctgctgt cagagttcaa     2520

cgtcctgaag caggtcaacc acccacatgt catcaaattg tatggggcct gcagccagga     2580

tggcccgctc ctcctcatcg tggagtacgc caaatacggc tccctgcggg gcttcctccg     2640

cgagagccgc aaagtggggc ctggctacct gggcagtgga ggcagccgca actccagctc     2700

cctggaccac ccggatgagc gggccctcac catgggcgac ctcatctcat ttgcctggca     2760

gatctcacag gggatgcagt atctggccga gatgaagctc gttcatcggg acttggcagc     2820

cagaaacatc ctggtagctg aggggcggaa gatgaagatt tcggatttcg gcttgtcccg     2880

agatgtttat gaagaggatt cctacgtgaa gaggagccag ggtcggattc cagttaaatg     2940

gatggcaatt gaatcccttt ttgatcatat ctacaccacg caaagtgatg tatggtcttt     3000

tggtgtcctg ctgtgggaga tcgtgaccct agggggaaac ccctatcctg ggattcctcc     3060

tgagcggctc ttcaaccttc tgaagaccgg ccaccggatg gagaggccag acaactgcag     3120

cgaggagatg taccgcctga tgctgcaatg ctggaagcag gagccggaca aaaggccggt     3180

gtttgcggac atcagcaaag acctggagaa gatgatggtt aagaggagag actacttgga     3240

ccttgcggcg tccactccat ctgactccct gatttatgac gacggcctct cagaggagga     3300

gacaccgctg gtggactgta ataatgcccc cctccctcga gccctccctt ccacatggat     3360

tgaaaacaaa ctctatggca tgtcagaccc gaactggcct ggagagagtc ctgtaccact     3420

cacgagagct gatggcacta acactgggtt tccaagatat ccaaatgata gtgtatatgc     3480

taactggatg ctttcaccct cagcggcaaa attaatggac acgtttgata gttaacattt     3540

ctttgtgaaa ggtaatggac tcacaagggg aagaaacatg ctgagaatgg aaagtctacc     3600

ggccctttct ttgtgaacgt cacattggcc gagccgtgtt cagttcccag gtggcagact     3660

cgtttttggt agtttgtttt aacttccaag gtggttttac ttctgatagc cggtgatttt     3720

ccctcctagc agacatgcca caccgggtaa gagctctgag tcttagtggt taagcattcc     3780

tttctcttca gtgcccagca gcacccagtg ttggtctgtg tccatcagtg accaccaaca     3840

ttctgtgttc acatgtgtgg gtccaacact tactacctgg tgtatgaaat tggacctgaa     3900

ctgttggatt tttctagttg ccgccaaaca aggcaaaaaa atttaaacat gaagcacaca     3960

cacaaaaaag gcagtaggaa aaatgctggc cctgatgacc tgtccttatt cagaatgaga     4020

gactgcgggg ggggcctggg ggtagtgtca atgcccctcc agggctggag gggaagaggg     4080

gccccgagga tgggcctggg ctcagcattc gagatcttga gaatgatttt ttttaaatca     4140

tgcaaccttt ccttaggaag acatttggtt ttcatcatga ttaagatgat tcctagattt     4200

agcacaatgg agagattcca tgccatcttt actatgtgga tggtggtatc agggaagagg     4260

gctcacaaga cacatttgtc ccccgggccc accacatcat cctcacgtgt tcggtactga     4320

gcagccacta cccctgatga gaacagtatg aagaaagggg gctgttggag tcccagaatt     4380

gctgacagca gaggctttgc tgctgtgaat cccacctgcc accagcctgc agcacacccc     4440

acagccaagt agaggcgaaa gcagtggctc atcctacctg ttaggagcag gtagggcttg     4500

tactcacttt aatttgaatc ttatcaactt actcataaag ggacaggcta gctagctgtg     4560

ttagaagtag caatgacaat gaccaaggac tgctacacct ctgattacaa ttctgatgtg     4620

aaaaagatgg tgtttggctc ttatagagcc tgtgtgaaag gcccatggat cagctcttcc     4680

tgtgtttgta atttaatgct gctacaagat gtttctgttt cttagattct gaccatgact     4740

cataagcttc ttgtcattct tcattgcttg tttgtggtca cagatgcaca acactcctcc     4800

agtcttgtgg gggcagcttt tgggaagtct cagcagctct tctggctgtg ttgtcagcac     4860

tgtaacttcg cagaaaagag tcggattacc aaaacactgc ctgctcttca gacttaaagc     4920

actgatagga cttaaaatag tctcattcaa atactgtatt ttatataggc atttcacaaa     4980

aacagcaaaa ttgtggcatt ttgtgaggcc aaggcttgga tgcgtgtgta atagagcctt     5040

gtggtgtgtg cgcacacacc cagagggaga gtttgaaaaa tgcttattgg acacgtaacc     5100

tggctctaat ttgggctgtt tttcagatac actgtgataa gttcttttac aaatatctat     5160

agacatggta aacttttggt tttcagatat gcttaatgat agtcttacta aatgcagaaa     5220

taagaataaa ctttctcaaa ttattaaaaa tgcctacaca gtaagtgtga attgctgcaa     5280

caggtttgtt ctcaggaggg taagaactcc aggtctaaac agctgaccca gtgatgggga     5340

atttatcctt gaccaattta tccttgacca ataacctaat tgtctattcc tgagttataa     5400

aagtccccat ccttattagc tctactggaa ttttcataca cgtaaatgca gaagttacta     5460

agtattaagt attactgagt attaagtagt aatctgtcag ttattaaaat ttgtaaaatc     5520

tatttatgaa aggtcattaa accagatcat gttccttttt ttgtaatcaa ggtgactaag     5580

aaaatcagtt gtgtaaataa aatcatgtat cataaaa                              5617


<210>  38
<211>  1114
<212>  PRT
<213>  Homo sapiens

<400>  38

Met Ala Lys Ala Thr Ser Gly Ala Ala Gly Leu Arg Leu Leu Leu Leu 
1               5                   10                  15      


Leu Leu Leu Pro Leu Leu Gly Lys Val Ala Leu Gly Leu Tyr Phe Ser 
            20                  25                  30          


Arg Asp Ala Tyr Trp Glu Lys Leu Tyr Val Asp Gln Ala Ala Gly Thr 
        35                  40                  45              


Pro Leu Leu Tyr Val His Ala Leu Arg Asp Ala Pro Glu Glu Val Pro 
    50                  55                  60                  


Ser Phe Arg Leu Gly Gln His Leu Tyr Gly Thr Tyr Arg Thr Arg Leu 
65                  70                  75                  80  


His Glu Asn Asn Trp Ile Cys Ile Gln Glu Asp Thr Gly Leu Leu Tyr 
                85                  90                  95      


Leu Asn Arg Ser Leu Asp His Ser Ser Trp Glu Lys Leu Ser Val Arg 
            100                 105                 110         


Asn Arg Gly Phe Pro Leu Leu Thr Val Tyr Leu Lys Val Phe Leu Ser 
        115                 120                 125             


Pro Thr Ser Leu Arg Glu Gly Glu Cys Gln Trp Pro Gly Cys Ala Arg 
    130                 135                 140                 


Val Tyr Phe Ser Phe Phe Asn Thr Ser Phe Pro Ala Cys Ser Ser Leu 
145                 150                 155                 160 


Lys Pro Arg Glu Leu Cys Phe Pro Glu Thr Arg Pro Ser Phe Arg Ile 
                165                 170                 175     


Arg Glu Asn Arg Pro Pro Gly Thr Phe His Gln Phe Arg Leu Leu Pro 
            180                 185                 190         


Val Gln Phe Leu Cys Pro Asn Ile Ser Val Ala Tyr Arg Leu Leu Glu 
        195                 200                 205             


Gly Glu Gly Leu Pro Phe Arg Cys Ala Pro Asp Ser Leu Glu Val Ser 
    210                 215                 220                 


Thr Arg Trp Ala Leu Asp Arg Glu Gln Arg Glu Lys Tyr Glu Leu Val 
225                 230                 235                 240 


Ala Val Cys Thr Val His Ala Gly Ala Arg Glu Glu Val Val Met Val 
                245                 250                 255     


Pro Phe Pro Val Thr Val Tyr Asp Glu Asp Asp Ser Ala Pro Thr Phe 
            260                 265                 270         


Pro Ala Gly Val Asp Thr Ala Ser Ala Val Val Glu Phe Lys Arg Lys 
        275                 280                 285             


Glu Asp Thr Val Val Ala Thr Leu Arg Val Phe Asp Ala Asp Val Val 
    290                 295                 300                 


Pro Ala Ser Gly Glu Leu Val Arg Arg Tyr Thr Ser Thr Leu Leu Pro 
305                 310                 315                 320 


Gly Asp Thr Trp Ala Gln Gln Thr Phe Arg Val Glu His Trp Pro Asn 
                325                 330                 335     


Glu Thr Ser Val Gln Ala Asn Gly Ser Phe Val Arg Ala Thr Val His 
            340                 345                 350         


Asp Tyr Arg Leu Val Leu Asn Arg Asn Leu Ser Ile Ser Glu Asn Arg 
        355                 360                 365             


Thr Met Gln Leu Ala Val Leu Val Asn Asp Ser Asp Phe Gln Gly Pro 
    370                 375                 380                 


Gly Ala Gly Val Leu Leu Leu His Phe Asn Val Ser Val Leu Pro Val 
385                 390                 395                 400 


Ser Leu His Leu Pro Ser Thr Tyr Ser Leu Ser Val Ser Arg Arg Ala 
                405                 410                 415     


Arg Arg Phe Ala Gln Ile Gly Lys Val Cys Val Glu Asn Cys Gln Ala 
            420                 425                 430         


Phe Ser Gly Ile Asn Val Gln Tyr Lys Leu His Ser Ser Gly Ala Asn 
        435                 440                 445             


Cys Ser Thr Leu Gly Val Val Thr Ser Ala Glu Asp Thr Ser Gly Ile 
    450                 455                 460                 


Leu Phe Val Asn Asp Thr Lys Ala Leu Arg Arg Pro Lys Cys Ala Glu 
465                 470                 475                 480 


Leu His Tyr Met Val Val Ala Thr Asp Gln Gln Thr Ser Arg Gln Ala 
                485                 490                 495     


Gln Ala Gln Leu Leu Val Thr Val Glu Gly Ser Tyr Val Ala Glu Glu 
            500                 505                 510         


Ala Gly Cys Pro Leu Ser Cys Ala Val Ser Lys Arg Arg Leu Glu Cys 
        515                 520                 525             


Glu Glu Cys Gly Gly Leu Gly Ser Pro Thr Gly Arg Cys Glu Trp Arg 
    530                 535                 540                 


Gln Gly Asp Gly Lys Gly Ile Thr Arg Asn Phe Ser Thr Cys Ser Pro 
545                 550                 555                 560 


Ser Thr Lys Thr Cys Pro Asp Gly His Cys Asp Val Val Glu Thr Gln 
                565                 570                 575     


Asp Ile Asn Ile Cys Pro Gln Asp Cys Leu Arg Gly Ser Ile Val Gly 
            580                 585                 590         


Gly His Glu Pro Gly Glu Pro Arg Gly Ile Lys Ala Gly Tyr Gly Thr 
        595                 600                 605             


Cys Asn Cys Phe Pro Glu Glu Glu Lys Cys Phe Cys Glu Pro Glu Asp 
    610                 615                 620                 


Ile Gln Asp Pro Leu Cys Asp Glu Leu Cys Arg Thr Val Ile Ala Ala 
625                 630                 635                 640 


Ala Val Leu Phe Ser Phe Ile Val Ser Val Leu Leu Ser Ala Phe Cys 
                645                 650                 655     


Ile His Cys Tyr His Lys Phe Ala His Lys Pro Pro Ile Ser Ser Ala 
            660                 665                 670         


Glu Met Thr Phe Arg Arg Pro Ala Gln Ala Phe Pro Val Ser Tyr Ser 
        675                 680                 685             


Ser Ser Gly Ala Arg Arg Pro Ser Leu Asp Ser Met Glu Asn Gln Val 
    690                 695                 700                 


Ser Val Asp Ala Phe Lys Ile Leu Glu Asp Pro Lys Trp Glu Phe Pro 
705                 710                 715                 720 


Arg Lys Asn Leu Val Leu Gly Lys Thr Leu Gly Glu Gly Glu Phe Gly 
                725                 730                 735     


Lys Val Val Lys Ala Thr Ala Phe His Leu Lys Gly Arg Ala Gly Tyr 
            740                 745                 750         


Thr Thr Val Ala Val Lys Met Leu Lys Glu Asn Ala Ser Pro Ser Glu 
        755                 760                 765             


Leu Arg Asp Leu Leu Ser Glu Phe Asn Val Leu Lys Gln Val Asn His 
    770                 775                 780                 


Pro His Val Ile Lys Leu Tyr Gly Ala Cys Ser Gln Asp Gly Pro Leu 
785                 790                 795                 800 


Leu Leu Ile Val Glu Tyr Ala Lys Tyr Gly Ser Leu Arg Gly Phe Leu 
                805                 810                 815     


Arg Glu Ser Arg Lys Val Gly Pro Gly Tyr Leu Gly Ser Gly Gly Ser 
            820                 825                 830         


Arg Asn Ser Ser Ser Leu Asp His Pro Asp Glu Arg Ala Leu Thr Met 
        835                 840                 845             


Gly Asp Leu Ile Ser Phe Ala Trp Gln Ile Ser Gln Gly Met Gln Tyr 
    850                 855                 860                 


Leu Ala Glu Met Lys Leu Val His Arg Asp Leu Ala Ala Arg Asn Ile 
865                 870                 875                 880 


Leu Val Ala Glu Gly Arg Lys Met Lys Ile Ser Asp Phe Gly Leu Ser 
                885                 890                 895     


Arg Asp Val Tyr Glu Glu Asp Ser Tyr Val Lys Arg Ser Gln Gly Arg 
            900                 905                 910         


Ile Pro Val Lys Trp Met Ala Ile Glu Ser Leu Phe Asp His Ile Tyr 
        915                 920                 925             


Thr Thr Gln Ser Asp Val Trp Ser Phe Gly Val Leu Leu Trp Glu Ile 
    930                 935                 940                 


Val Thr Leu Gly Gly Asn Pro Tyr Pro Gly Ile Pro Pro Glu Arg Leu 
945                 950                 955                 960 


Phe Asn Leu Leu Lys Thr Gly His Arg Met Glu Arg Pro Asp Asn Cys 
                965                 970                 975     


Ser Glu Glu Met Tyr Arg Leu Met Leu Gln Cys Trp Lys Gln Glu Pro 
            980                 985                 990         


Asp Lys Arg Pro Val Phe Ala Asp  Ile Ser Lys Asp Leu  Glu Lys Met 
        995                 1000                 1005             


Met Val  Lys Arg Arg Asp Tyr  Leu Asp Leu Ala Ala  Ser Thr Pro 
    1010                 1015                 1020             


Ser Asp  Ser Leu Ile Tyr Asp  Asp Gly Leu Ser Glu  Glu Glu Thr 
    1025                 1030                 1035             


Pro Leu  Val Asp Cys Asn Asn  Ala Pro Leu Pro Arg  Ala Leu Pro 
    1040                 1045                 1050             


Ser Thr  Trp Ile Glu Asn Lys  Leu Tyr Gly Met Ser  Asp Pro Asn 
    1055                 1060                 1065             


Trp Pro  Gly Glu Ser Pro Val  Pro Leu Thr Arg Ala  Asp Gly Thr 
    1070                 1075                 1080             


Asn Thr  Gly Phe Pro Arg Tyr  Pro Asn Asp Ser Val  Tyr Ala Asn 
    1085                 1090                 1095             


Trp Met  Leu Ser Pro Ser Ala  Ala Lys Leu Met Asp  Thr Phe Asp 
    1100                 1105                 1110             


Ser 
    


<210>  39
<211>  4483
<212>  DNA
<213>  Homo sapiens

<400>  39
actgcgggcg gagcagaggg aaacaccaga gtctgtgact ccagacagga cccactgtgt       60

cctcttgaac tttgcacagc gcgtgacggg ggcagacggt gcaccgtggc ccggcctttc      120

gcgggggtcc tcggggaaga gagaggagcg cgggtttcct cggaggcctg agcgggacgc      180

agcctgcagc ccctccccgc acgggctgcc cccggcccgc cgctcgcgcc gctctgctgg      240

gatccggcgc cttccccggc tgtcctcggc ctcccgcgcg ctccgcggga ggagccgcca      300

gcggccgtga cgcgtcaagg aggaaacgcc ggcgcccggc ggccctgccg ggaaggagga      360

agcgcagtgc gttcggctcc gcgcccgccg cgccgggagc agcaccgcgg ggccaggttg      420

catgatggaa tttgaacatt acttcaagag gttttgtatt ttggattagt taattgggtt      480

tgtcctctgc tgactgtttc ttcggatgca ttttttggtg tgctcttgag ggattaaatg      540

caaagagatc acaccatgga ctacaaggaa agctgcccaa gtgtaagcat tcccagctcc      600

gatgaacaca gagagaaaaa gaagaggttt actgtttata aagttctggt ttcagtggga      660

agaagtgaat ggtttgtctt caggagatat gcagagtttg ataaacttta taacacttta      720

aaaaaacagt ttcctgctat ggccctgaag attcctgcca agagaatatt tggtgataat      780

tttgatccag attttattaa acaaagacga gcaggactaa acgaattcat tcagaaccta      840

gttaggtatc cagaacttta taaccatcca gatgtcagag cattccttca aatggacagt      900

ccaaaacacc agtcagatcc atctgaagat gaggatgaaa gaagttctca gaagctacac      960

tctacctcac agaacatcaa cctgggaccg tctggaaatc ctcatgccaa accaactgac     1020

tttgatttct taaaagttat tggaaaaggc agctttggca aggttcttct tgcaaaacgg     1080

aaactggatg gaaaatttta tgctgtcaaa gtgttacaga aaaaaatagt tctcaacaga     1140

aaagagcaaa aacatattat ggctgaacgt aatgtgctct tgaaaaatgt gaaacatccg     1200

tttttggttg gattgcatta ttccttccaa acaactgaaa agctttattt tgttctggat     1260

tttgttaatg gaggggagct ttttttccac ttacaaagag aacggtcctt tcctgagcac     1320

agagctaggt tttacgctgc tgaaattgct agtgcattgg gttacttaca ttccatcaaa     1380

atagtataca gagacttgaa accagaaaat attcttttgg attcagtagg acatgttgtc     1440

ttaacagatt ttgggctttg taaagaagga attgctattt ctgacaccac taccacattt     1500

tgtgggacac cagagtatct tgcacctgaa gtaattagaa aacagcccta tgacaatact     1560

gtagattggt ggtgccttgg ggctgttctg tatgaaatgc tgtatggatt gcctcctttt     1620

tattgccgag atgttgctga aatgtatgac aatatccttc acaaacccct aagtttgagg     1680

ccaggagtga gtcttacagc ctggtccatt ctggaagaac tcctagaaaa agacaggcaa     1740

aatcgacttg gtgccaagga agactttctt gaaattcaga atcatccttt ttttgaatca     1800

ctcagctggg ctgaccttgt acaaaagaag attccaccac catttaatcc taatgtggct     1860

ggaccagatg atatcagaaa ctttgacaca gcatttacag aagaaacagt tccatattct     1920

gtgtgtgtat cttctgacta ttctatagtg aatgccagtg tattggaggc agatgatgca     1980

ttcgttggtt tctcttatgc acctccttca gaagacttat ttttgtgagc agtttgccat     2040

tcagaaacca ttgagcaaaa taagtctata gatgggactg aaacttctat ttgtgtgaat     2100

atattcaaat atgtataact agtgcctcat ttttatatgt aatgatgaaa actatgaaaa     2160

aatgtatttt cttctatgtg caagaaaaat agggcatttc aaagagctgt tttgattaaa     2220

atttatattc ttgtttaata agcttatttt taaacaattt aaaagctatt attcttagca     2280

ttaacctatt tttaaagaaa ccttttttgc tattgactgt tttttccctc taagtttaca     2340

ctaacatcta cccaagatag actgtttttt aacagtcaat ttcagttcag ctaacatata     2400

ttaatacctt tgtaactctt tgctatggct tttgttatca caccaaaact atgcaattgg     2460

tacatggttg tttaagaaga aaccgtattt ttccatgata aatcactgtt tgaaatattt     2520

ggttcatggt atgatcgaaa tgtaaaagca taattaacac attggctgct agttaacaat     2580

tggaataact ttattctgca gatcatttaa gaagtaacag gccgggcgcg gtggctcacg     2640

cctgtaatcc cagcactttg ggaggctgag gcgggcagat cacctgaggt caggagttgg     2700

agaccagcct gaccaacatg gacaaacccc gtctctacta aaaatacaaa attggcaggg     2760

tgtggtggca catgcctata atcccagcta cttgggaggc taaggcagga gaatcgcttg     2820

aacccgggag gcggaggttg cagtgagccg agatcgcacc attgcactcc tgcctgggca     2880

acaagagtga aactccatct ccaaaaaaaa aaagaaaaag taacaaaagg aaattatttg     2940

tttttgaaat accagttcaa ctttgtggat tatttttcct ctgaaggaaa agaaaaggct     3000

taatggttag gatttttaag tattcccaaa gatctgaagg gtaataaaat gtactggatt     3060

ttttaaggtg gtaccaaaaa tgaatgtctg tcatatattt atattacaaa tacattatat     3120

ttatgttcta ttcatctttt gaatgtttag tatgctatta agtcattctg aatctttgta     3180

tttgcttttg caaataggta tttcaaagct cttttcctaa ctggttaagt aaaataaaaa     3240

attgagcttt ctagaatatt tgcctaattg ggaattaaaa agtaaaataa taggccaggc     3300

atggtggctc atgcctataa gcaccctggg aggccgaggc aggcagatta tttgagctca     3360

ggagtttgag accatcctgg gcaacatggc gaaaccctat ctctacaaaa aatacaaaaa     3420

ttagccagac atggtggcac atgcctttag tcccagctac tctggaggct gaagttggag     3480

gatggcttga gcccacgaga tggaagttgc agtgaactga aattgtgcca ctgcactttt     3540

cagcctgggt gccacagcga gaccctagtt aagagaaaaa aaaagtaaaa acaaattgtg     3600

ggtcaaagta aatgtataca gttttattac aatgtaacaa aagttgaaaa tcaggcagat     3660

gtgtattcag tatccaattc aatatatctt agaaaaagca caggaaacag accttaaaat     3720

tgtaacctac caactaactt acatgcttat aaaagtaaag gagaataact ggccgggcac     3780

ggtggctcat gcctataaaa ttccagcact ttgggaggcc aaggcaggag gatcacttga     3840

gcctatgagt tcaagaccag cctaggcaat gtagtgacac ctcatttcta tttattttaa     3900

aaaaaagaga gagtaactac agaagaactt taaaaaataa aaaataagct taccttggat     3960

tcttggctta gagtagaggt tttttttaag ttatggagga aacatttttg taaaagttta     4020

atgacccact ttagatgctc caagaacaag catcccttcc atgtatgtct tgagaaagaa     4080

atcacagaag catttctcac caatactctt tggcttaaaa tgttcagcag aattgggcag     4140

tgggggtgac ttttcttata ttaataatat ttacatccaa tacactgaat cttcctttag     4200

aggtaagact ttaatatcta tactgtaaat atttggttta tttggcacta ctgtaagttt     4260

tgtttttcac aaagctctta ttatgaagca aaataaaaat tctagtttct tgtatgattt     4320

tttgtactca ttcattcctg ttaagctgcc aaaaattaaa gtgcaatatt gtatattttt     4380

aagaacaaat ttaaaataga attttgatgt ttctcagatc acaagaaata caaatctata     4440

tagtataata aaatcagcaa aaagatcaaa aaaaaaaaaa aaa                       4483


<210>  40
<211>  496
<212>  PRT
<213>  Homo sapiens

<400>  40

Met Gln Arg Asp His Thr Met Asp Tyr Lys Glu Ser Cys Pro Ser Val 
1               5                   10                  15      


Ser Ile Pro Ser Ser Asp Glu His Arg Glu Lys Lys Lys Arg Phe Thr 
            20                  25                  30          


Val Tyr Lys Val Leu Val Ser Val Gly Arg Ser Glu Trp Phe Val Phe 
        35                  40                  45              


Arg Arg Tyr Ala Glu Phe Asp Lys Leu Tyr Asn Thr Leu Lys Lys Gln 
    50                  55                  60                  


Phe Pro Ala Met Ala Leu Lys Ile Pro Ala Lys Arg Ile Phe Gly Asp 
65                  70                  75                  80  


Asn Phe Asp Pro Asp Phe Ile Lys Gln Arg Arg Ala Gly Leu Asn Glu 
                85                  90                  95      


Phe Ile Gln Asn Leu Val Arg Tyr Pro Glu Leu Tyr Asn His Pro Asp 
            100                 105                 110         


Val Arg Ala Phe Leu Gln Met Asp Ser Pro Lys His Gln Ser Asp Pro 
        115                 120                 125             


Ser Glu Asp Glu Asp Glu Arg Ser Ser Gln Lys Leu His Ser Thr Ser 
    130                 135                 140                 


Gln Asn Ile Asn Leu Gly Pro Ser Gly Asn Pro His Ala Lys Pro Thr 
145                 150                 155                 160 


Asp Phe Asp Phe Leu Lys Val Ile Gly Lys Gly Ser Phe Gly Lys Val 
                165                 170                 175     


Leu Leu Ala Lys Arg Lys Leu Asp Gly Lys Phe Tyr Ala Val Lys Val 
            180                 185                 190         


Leu Gln Lys Lys Ile Val Leu Asn Arg Lys Glu Gln Lys His Ile Met 
        195                 200                 205             


Ala Glu Arg Asn Val Leu Leu Lys Asn Val Lys His Pro Phe Leu Val 
    210                 215                 220                 


Gly Leu His Tyr Ser Phe Gln Thr Thr Glu Lys Leu Tyr Phe Val Leu 
225                 230                 235                 240 


Asp Phe Val Asn Gly Gly Glu Leu Phe Phe His Leu Gln Arg Glu Arg 
                245                 250                 255     


Ser Phe Pro Glu His Arg Ala Arg Phe Tyr Ala Ala Glu Ile Ala Ser 
            260                 265                 270         


Ala Leu Gly Tyr Leu His Ser Ile Lys Ile Val Tyr Arg Asp Leu Lys 
        275                 280                 285             


Pro Glu Asn Ile Leu Leu Asp Ser Val Gly His Val Val Leu Thr Asp 
    290                 295                 300                 


Phe Gly Leu Cys Lys Glu Gly Ile Ala Ile Ser Asp Thr Thr Thr Thr 
305                 310                 315                 320 


Phe Cys Gly Thr Pro Glu Tyr Leu Ala Pro Glu Val Ile Arg Lys Gln 
                325                 330                 335     


Pro Tyr Asp Asn Thr Val Asp Trp Trp Cys Leu Gly Ala Val Leu Tyr 
            340                 345                 350         


Glu Met Leu Tyr Gly Leu Pro Pro Phe Tyr Cys Arg Asp Val Ala Glu 
        355                 360                 365             


Met Tyr Asp Asn Ile Leu His Lys Pro Leu Ser Leu Arg Pro Gly Val 
    370                 375                 380                 


Ser Leu Thr Ala Trp Ser Ile Leu Glu Glu Leu Leu Glu Lys Asp Arg 
385                 390                 395                 400 


Gln Asn Arg Leu Gly Ala Lys Glu Asp Phe Leu Glu Ile Gln Asn His 
                405                 410                 415     


Pro Phe Phe Glu Ser Leu Ser Trp Ala Asp Leu Val Gln Lys Lys Ile 
            420                 425                 430         


Pro Pro Pro Phe Asn Pro Asn Val Ala Gly Pro Asp Asp Ile Arg Asn 
        435                 440                 445             


Phe Asp Thr Ala Phe Thr Glu Glu Thr Val Pro Tyr Ser Val Cys Val 
    450                 455                 460                 


Ser Ser Asp Tyr Ser Ile Val Asn Ala Ser Val Leu Glu Ala Asp Asp 
465                 470                 475                 480 


Ala Phe Val Gly Phe Ser Tyr Ala Pro Pro Ser Glu Asp Leu Phe Leu 
                485                 490                 495     


<210>  41
<211>  2032
<212>  DNA
<213>  Homo sapiens

<400>  41
ggactctggg acgctcagac gccgcgcggg gcggggattg gtctgtggtc ctctctcggc       60

tcctcgcggc tcgcggcggc cgacggttcc tgggacacct gcttgcttgg cccgtccggc      120

ggctcagggc ttctctgctg cgctcccggt tcgctggacg ggaagaaggg ctgggccgtc      180

ccgtcccgtc cccatcggaa ccccaagtcg cgccgctgac ccgtcgcagg gcgagatgag      240

cgcggacgca gcggccgggg cgcccctgcc ccggctctgc tgcctggaga agggtccgaa      300

cggctacggc ttccacctgc acggggagaa gggcaagttg ggccagtaca tccggctggt      360

ggagcccggc tcgccggccg agaaggcggg gctgctggcg ggggaccggc tggtggaggt      420

gaacggcgaa aacgtggaga aggagaccca ccagcaggtg gtgagccgca tccgcgccgc      480

actcaacgcc gtgcgcctgc tggtggtcga ccccgagacg gacgagcagc tgcagaagct      540

cggcgtccag gtccgagagg agctgctgcg cgcccaggaa gcgccggggc aggccgagcc      600

gccggccgcc gccgaggtgc agggggctgg caacgaaaat gagcctcgcg aggccgacaa      660

gagccacccg gagcagcgcg agcttcggcc tcggctctgt accatgaaga agggccccag      720

tggctatggc ttcaacctgc acagcgacaa gtccaagcca ggccagttca tccggtcagt      780

ggacccagac tccccggctg aggcttcagg gctccgggcc caggatcgca ttgtggaggt      840

gaacggggtc tgcatggagg ggaagcagca tggggacgtg gtgtccgcca tcagggctgg      900

cggggacgag accaagctgc tggtggtgga cagggaaact gacgagttct tcaagaaatg      960

cagagtgatc ccatctcagg agcacctgaa tggtcccctg cctgtgccct tcaccaatgg     1020

ggagatacag aaggagaaca gtcgtgaagc cctggcagag gcagccttgg agagccccag     1080

gccagccctg gtgagatccg cctccagtga caccagcgag gagctgaatt cccaagacag     1140

ccccccaaaa caggactcca cagcgccctc gtctacctcc tcctccgacc ccatcctaga     1200

cttcaacatc tccctggcca tggccaaaga gagggcccac cagaaacgca gcagcaaacg     1260

ggccccgcag atggactgga gcaagaaaaa cgaactcttc agcaacctct gagcgccctg     1320

ctgccaccca gtgactggca gggccgagcc agcattccac cccacctttt tccttctccc     1380

caattactcc cctgaatcaa tgtacaaatc agcacccaca tcccctttct tgacaaatga     1440

tttttctaga gaactatgtt cttccctgac tttagggaag gtgaatgtgt tcccgtcctc     1500

ccgcagtcag aaaggagact ctgcctccct cctcctcact gagtgcctca tcctaccggg     1560

tgtccctttg ccaccctgcc tgggacatcg ctggaacctg caccatgcca ggatcatggg     1620

accaggcgag agggcaccct cccttcctcc cccatgtgat aaatgggtcc agggctgatc     1680

aaagaactct gactgcagaa ctgccgctct cagtggacag ggcatctgtt accctgagac     1740

ctgtggcaga cacgtcttgt tttcatttga tttttgttaa gagtgcagta ttgcagagtc     1800

tagaggaatt tttgtttcct tgattaacat gattttcctg gttgttacat ccagggcatg     1860

gcagtggcct cagccttaaa cttttgttcc tactcccacc ctcagcgaac tgggcagcac     1920

ggggagggtt tggctacccc tgcccatccc tgagccaggt accaccattg taaggaaaca     1980

ctttcagaaa ttcagctggt tcctccaaac ccttcaaaaa aaaaaaaaaa aa             2032


<210>  42
<211>  358
<212>  PRT
<213>  Homo sapiens

<400>  42

Met Ser Ala Asp Ala Ala Ala Gly Ala Pro Leu Pro Arg Leu Cys Cys 
1               5                   10                  15      


Leu Glu Lys Gly Pro Asn Gly Tyr Gly Phe His Leu His Gly Glu Lys 
            20                  25                  30          


Gly Lys Leu Gly Gln Tyr Ile Arg Leu Val Glu Pro Gly Ser Pro Ala 
        35                  40                  45              


Glu Lys Ala Gly Leu Leu Ala Gly Asp Arg Leu Val Glu Val Asn Gly 
    50                  55                  60                  


Glu Asn Val Glu Lys Glu Thr His Gln Gln Val Val Ser Arg Ile Arg 
65                  70                  75                  80  


Ala Ala Leu Asn Ala Val Arg Leu Leu Val Val Asp Pro Glu Thr Asp 
                85                  90                  95      


Glu Gln Leu Gln Lys Leu Gly Val Gln Val Arg Glu Glu Leu Leu Arg 
            100                 105                 110         


Ala Gln Glu Ala Pro Gly Gln Ala Glu Pro Pro Ala Ala Ala Glu Val 
        115                 120                 125             


Gln Gly Ala Gly Asn Glu Asn Glu Pro Arg Glu Ala Asp Lys Ser His 
    130                 135                 140                 


Pro Glu Gln Arg Glu Leu Arg Pro Arg Leu Cys Thr Met Lys Lys Gly 
145                 150                 155                 160 


Pro Ser Gly Tyr Gly Phe Asn Leu His Ser Asp Lys Ser Lys Pro Gly 
                165                 170                 175     


Gln Phe Ile Arg Ser Val Asp Pro Asp Ser Pro Ala Glu Ala Ser Gly 
            180                 185                 190         


Leu Arg Ala Gln Asp Arg Ile Val Glu Val Asn Gly Val Cys Met Glu 
        195                 200                 205             


Gly Lys Gln His Gly Asp Val Val Ser Ala Ile Arg Ala Gly Gly Asp 
    210                 215                 220                 


Glu Thr Lys Leu Leu Val Val Asp Arg Glu Thr Asp Glu Phe Phe Lys 
225                 230                 235                 240 


Lys Cys Arg Val Ile Pro Ser Gln Glu His Leu Asn Gly Pro Leu Pro 
                245                 250                 255     


Val Pro Phe Thr Asn Gly Glu Ile Gln Lys Glu Asn Ser Arg Glu Ala 
            260                 265                 270         


Leu Ala Glu Ala Ala Leu Glu Ser Pro Arg Pro Ala Leu Val Arg Ser 
        275                 280                 285             


Ala Ser Ser Asp Thr Ser Glu Glu Leu Asn Ser Gln Asp Ser Pro Pro 
    290                 295                 300                 


Lys Gln Asp Ser Thr Ala Pro Ser Ser Thr Ser Ser Ser Asp Pro Ile 
305                 310                 315                 320 


Leu Asp Phe Asn Ile Ser Leu Ala Met Ala Lys Glu Arg Ala His Gln 
                325                 330                 335     


Lys Arg Ser Ser Lys Arg Ala Pro Gln Met Asp Trp Ser Lys Lys Asn 
            340                 345                 350         


Glu Leu Phe Ser Asn Leu 
        355             


<210>  43
<211>  492
<212>  DNA
<213>  Homo sapiens

<400>  43
atccctgact cggggtcgcc tttggagcag agaggaggca atggccacca tggagaacaa       60

ggtgatctgc gccctggtcc tggtgtccat gctggccctc ggcaccctgg ccgaggccca      120

gacagagacg tgtacagtgg ccccccgtga aagacagaat tgtggttttc ctggtgtcac      180

gccctcccag tgtgcaaata agggctgctg tttcgacgac accgttcgtg gggtcccctg      240

gtgcttctat cctaatacca tcgacgtccc tccagaagag gagtgtgaat tttagacact      300

tctgcaggga tctgcctgca tcctgacgcg gtgccgtccc cagcacggtg attagtccca      360

gagctcggct gccacctcca ccggacacct cagacacgct tctgcagctg tgcctcggct      420

cacaacacag attgactgct ctgactttga ctactcaaaa ttggcctaaa aattaaaaga      480

gatcgatatt aa                                                          492


<210>  44
<211>  84
<212>  PRT
<213>  Homo sapiens

<400>  44

Met Ala Thr Met Glu Asn Lys Val Ile Cys Ala Leu Val Leu Val Ser 
1               5                   10                  15      


Met Leu Ala Leu Gly Thr Leu Ala Glu Ala Gln Thr Glu Thr Cys Thr 
            20                  25                  30          


Val Ala Pro Arg Glu Arg Gln Asn Cys Gly Phe Pro Gly Val Thr Pro 
        35                  40                  45              


Ser Gln Cys Ala Asn Lys Gly Cys Cys Phe Asp Asp Thr Val Arg Gly 
    50                  55                  60                  


Val Pro Trp Cys Phe Tyr Pro Asn Thr Ile Asp Val Pro Pro Glu Glu 
65                  70                  75                  80  


Glu Cys Glu Phe 
                


<210>  45
<211>  3316
<212>  DNA
<213>  Homo sapiens

<400>  45
ggtttttgtg ttgctagccg gggccagcgg cggtggcggc ggcggcggag gcgtcggtgg       60

aggaggggag gcggcgagga ggcgcagctc ccgctgcacc gcgatcgacg ctgcggagcg      120

agcccacccg ccccgggagc tcgcctcccc ggtgctcccc cgccctcccc gcccccccag      180

cggcgctgcc tcctccaaat gagcgattcg cccgctggat ctaacccaag gacacccgaa      240

agcagcggca gcggcagcgg cggcggcggg aagaggccgg cggtgccggc agcggtgtcc      300

ctcttgccac cggcggaccc cctgcgccag gcgaaccggc tcccgatcag ggtcctgaag      360

atgctgagcg ctcacaccgg tcacctcctg cacccggagt acctgcagcc gctgtcctcc      420

actcccgtca gccccattga gctggacgcc aagaagagcc ccttggcgct gctggctcag      480

acctgctcgc agatcggcaa gccggacccg ccgccctcct ccaaactcaa ctcggtggcg      540

gcggcggcca acgggctggg agcggagaag gaccccggcc gctcagcccc gggcgccgcc      600

tccgcagccg cggccctgaa gcagctgggg gactcaccgg ccgaggacaa gtccagcttc      660

aagccctact ccaagggctc cggcggcggc gactcccgca aagacagcgg ctcctcctcg      720

gtgtcttcca cctcctcctc gtcctcctcg tccccgggag acaaggcggg cttcagggtc      780

cccagcgccg cctgcccgcc ctttcccccg catggagcgc cggtctccgc atcctcgtcc      840

tcgtcgtcgc ccggcggctc ccgcggcggc tccccgcacc actctgactg caagaacggc      900

ggcggggttg gcggcgggga gctggacaag aaagaccagg agcccaagcc cagcccggag      960

ccggcagccg tgagccgcgg cggcggtggg gagcccgggg cgcacggtgg cgccgagtcc     1020

ggggcctccg ggcgcaagtc cgagccgccc tcggcgctgg tgggggccgg ccacgtggcg     1080

ccggtgtctc cctacaagcc gggccactcg gtgttcccgc tgccgccctc cagcattggc     1140

taccacggct ccatcgtggg cgcctacgcc ggctacccgt ctcagttcgt gcctggcctg     1200

gatcctagca agtccggcct cgtgggaggc cagctgtctg ggggcctggg cctgccgccg     1260

ggcaagcccc ccagctccag cccgctcacc ggggcctccc cgccctcctt cctgcaggga     1320

ttatgccgcg acccctattg cttgggaggt taccacggcg cctcgcacct cggcggctcc     1380

agctgctcca cctgcagcgc gcacgaccct gccgggccca gcctgaaggc ggggggctac     1440

ccgctggtgt accccgggca cccgctgcag cccgccgcgc tctcgtccag cgccgcccag     1500

gccgcgctcc ccggccaccc gctctacacc tacggcttca tgctgcagaa cgaaccgctg     1560

ccgcacagct gcaactgggt ggcagccagt gggccgtgcg acaagcgctt cgccacctcg     1620

gaggagctgc tcagccacct acggacccac acggccctgc cgggagccga gaaacttctg     1680

gccgcctacc ccggggcctc gggcctgggc agcgccgccg ccgccgccgc cgccgccgcc     1740

tcctgccatc tgcacctccc cccgcccgcc gcccccggca gccccgggtc gctgtccttg     1800

cggaatccac acactttggg cctaagccgg taccacccct atggcaagag ccacttatcc     1860

acagcggggg gcctggccgt gccgtccctc cccacagccg gaccctacta ttcgccatac     1920

gcgctgtatg gacagagact agcttcagcc tcggcgctgg gataccagta actacagctc     1980

ttcctccacc ccagccccct caccctcctc cctctccctc ctcctccctc cccacctgcc     2040

gtcgccgctg caacctccac tactgcttga ccctgccggg attccccacc cagcccttcc     2100

ccaccggact gtgtatttat ttactataat gttagcttac aagctgggaa tataagtgca     2160

ttaacggccc acatgagtca atggtatgca aaaagtctgt gttctcccaa ataataatat     2220

taatcccaca aataacgaca tgatccccgc ccctgttcct ttctgttatt ttttcttaga     2280

tataagtttt acatttttta ttccttttcc tctttttttg gttttgattg gtttggtttg     2340

agggagagtt ggggtctttg ggttcttcta gacgttttgt tttcccttcc tggggagttt     2400

cttgcatgag tcttaactta aaactacgtt tccgccttct ctttttccct cttccccctt     2460

cattccctct tgtttccttc catttgcggt tctgtttttg ttttttgttt tgttttgttt     2520

tgttttttcc tttgttgtac aagtaacaga gaggaggttt tttttgtaac tcattttggg     2580

ggtggagggg gccacctggg tggcaggggc cctggagctc tattgacctg gtacactgct     2640

ccgggactcc tcccccgcca ccctccgcgc atagggtcct tggtctggac cctgcccccc     2700

aaaagtaggg ccttgctcct ctaccttgct ctgagcacgg agagccctga ccccaccagt     2760

aggctcgccc ccagaagggc ccaagtggcc gtctaccgtc accttccaga ctcccgcccc     2820

taacacccag tggctacagt gcgcctgtcg gggcacctgg agcgctcacc tggttgaatt     2880

caaagtccca gaaggccccg ctggcgtgaa gccggcccct tacattttgc gaagtgcatt     2940

atagtccttg tttttctctc cctcgtgggg gcaacgaccc ctcccctggc agtaggggtg     3000

gggtaggtga ctctcgctag atccctccaa agcagaccgg tggcgatgtc agcggatgtc     3060

acgagctcgt tagctgcgtt cggggaaggt tggggcgtca gggagctctc ggatcacagc     3120

agcccccgcc ctctcctagg cctggcccgg cagagccccc agagtggacc ccccagcgac     3180

tggggtcttc tccccactcc tccctccttc tggtctgatg cggcagcgcg ggggctgcgg     3240

ggcctgtttg ggacgaacag agctctccct tggtaagact tattttgtta ataaatggaa     3300

tacttggcta tattca                                                     3316


<210>  46
<211>  590
<212>  PRT
<213>  Homo sapiens

<400>  46

Met Ser Asp Ser Pro Ala Gly Ser Asn Pro Arg Thr Pro Glu Ser Ser 
1               5                   10                  15      


Gly Ser Gly Ser Gly Gly Gly Gly Lys Arg Pro Ala Val Pro Ala Ala 
            20                  25                  30          


Val Ser Leu Leu Pro Pro Ala Asp Pro Leu Arg Gln Ala Asn Arg Leu 
        35                  40                  45              


Pro Ile Arg Val Leu Lys Met Leu Ser Ala His Thr Gly His Leu Leu 
    50                  55                  60                  


His Pro Glu Tyr Leu Gln Pro Leu Ser Ser Thr Pro Val Ser Pro Ile 
65                  70                  75                  80  


Glu Leu Asp Ala Lys Lys Ser Pro Leu Ala Leu Leu Ala Gln Thr Cys 
                85                  90                  95      


Ser Gln Ile Gly Lys Pro Asp Pro Pro Pro Ser Ser Lys Leu Asn Ser 
            100                 105                 110         


Val Ala Ala Ala Ala Asn Gly Leu Gly Ala Glu Lys Asp Pro Gly Arg 
        115                 120                 125             


Ser Ala Pro Gly Ala Ala Ser Ala Ala Ala Ala Leu Lys Gln Leu Gly 
    130                 135                 140                 


Asp Ser Pro Ala Glu Asp Lys Ser Ser Phe Lys Pro Tyr Ser Lys Gly 
145                 150                 155                 160 


Ser Gly Gly Gly Asp Ser Arg Lys Asp Ser Gly Ser Ser Ser Val Ser 
                165                 170                 175     


Ser Thr Ser Ser Ser Ser Ser Ser Ser Pro Gly Asp Lys Ala Gly Phe 
            180                 185                 190         


Arg Val Pro Ser Ala Ala Cys Pro Pro Phe Pro Pro His Gly Ala Pro 
        195                 200                 205             


Val Ser Ala Ser Ser Ser Ser Ser Ser Pro Gly Gly Ser Arg Gly Gly 
    210                 215                 220                 


Ser Pro His His Ser Asp Cys Lys Asn Gly Gly Gly Val Gly Gly Gly 
225                 230                 235                 240 


Glu Leu Asp Lys Lys Asp Gln Glu Pro Lys Pro Ser Pro Glu Pro Ala 
                245                 250                 255     


Ala Val Ser Arg Gly Gly Gly Gly Glu Pro Gly Ala His Gly Gly Ala 
            260                 265                 270         


Glu Ser Gly Ala Ser Gly Arg Lys Ser Glu Pro Pro Ser Ala Leu Val 
        275                 280                 285             


Gly Ala Gly His Val Ala Pro Val Ser Pro Tyr Lys Pro Gly His Ser 
    290                 295                 300                 


Val Phe Pro Leu Pro Pro Ser Ser Ile Gly Tyr His Gly Ser Ile Val 
305                 310                 315                 320 


Gly Ala Tyr Ala Gly Tyr Pro Ser Gln Phe Val Pro Gly Leu Asp Pro 
                325                 330                 335     


Ser Lys Ser Gly Leu Val Gly Gly Gln Leu Ser Gly Gly Leu Gly Leu 
            340                 345                 350         


Pro Pro Gly Lys Pro Pro Ser Ser Ser Pro Leu Thr Gly Ala Ser Pro 
        355                 360                 365             


Pro Ser Phe Leu Gln Gly Leu Cys Arg Asp Pro Tyr Cys Leu Gly Gly 
    370                 375                 380                 


Tyr His Gly Ala Ser His Leu Gly Gly Ser Ser Cys Ser Thr Cys Ser 
385                 390                 395                 400 


Ala His Asp Pro Ala Gly Pro Ser Leu Lys Ala Gly Gly Tyr Pro Leu 
                405                 410                 415     


Val Tyr Pro Gly His Pro Leu Gln Pro Ala Ala Leu Ser Ser Ser Ala 
            420                 425                 430         


Ala Gln Ala Ala Leu Pro Gly His Pro Leu Tyr Thr Tyr Gly Phe Met 
        435                 440                 445             


Leu Gln Asn Glu Pro Leu Pro His Ser Cys Asn Trp Val Ala Ala Ser 
    450                 455                 460                 


Gly Pro Cys Asp Lys Arg Phe Ala Thr Ser Glu Glu Leu Leu Ser His 
465                 470                 475                 480 


Leu Arg Thr His Thr Ala Leu Pro Gly Ala Glu Lys Leu Leu Ala Ala 
                485                 490                 495     


Tyr Pro Gly Ala Ser Gly Leu Gly Ser Ala Ala Ala Ala Ala Ala Ala 
            500                 505                 510         


Ala Ala Ser Cys His Leu His Leu Pro Pro Pro Ala Ala Pro Gly Ser 
        515                 520                 525             


Pro Gly Ser Leu Ser Leu Arg Asn Pro His Thr Leu Gly Leu Ser Arg 
    530                 535                 540                 


Tyr His Pro Tyr Gly Lys Ser His Leu Ser Thr Ala Gly Gly Leu Ala 
545                 550                 555                 560 


Val Pro Ser Leu Pro Thr Ala Gly Pro Tyr Tyr Ser Pro Tyr Ala Leu 
                565                 570                 575     


Tyr Gly Gln Arg Leu Ala Ser Ala Ser Ala Leu Gly Tyr Gln 
            580                 585                 590 


<210>  47
<211>  1691
<212>  DNA
<213>  Homo sapiens

<400>  47
gggctggcgc gggcgggagc tgcggcggat acccttgcgt gctgtggaga ccctactctc       60

ttcgctgaga acggccgcta gcggggactg aaggccggga gcccactccc gacccggggc      120

tagcgtgcgt ccctagagtc gagcggggca agggagccag tggccgccga cgggggaccg      180

ggaaactttt ctgggctcct gggcgcgccc tgtagccgcg ctccatgctc cggcagcggc      240

ccgaaaccca gccccgccgc tgacggcgcc cgccgctccg ggcagggccc atgccctgcg      300

cgctccgggg gtcgtaggct gccgccgagc cggggctccg gaagccggcg ggggcgccgc      360

ggccgtgcgg ggcgtcaatg gatcgccact ccagctacat cttcatctgg ctgcagctgg      420

agctctgcgc catggccgtg ctgctcacca aaggtgaaat tcgatgctac tgtgatgctg      480

cccactgtgt agccactggt tatatgtgta aatctgagct cagcgcctgc ttctctagac      540

ttcttgatcc tcagaactca aattccccac tcacccatgg ctgcctggac tctcttgcaa      600

gcacgacaga catctgccaa gccaaacagg cccgaaacca ctctggcacc accataccca      660

cattggaatg ctgtcatgaa gacatgtgca attacagagg gctgcacgat gttctctctc      720

ctcccagggg tgaggcctca ggacaaggaa acaggtatca gcatgatggt agcagaaacc      780

ttatcaccaa ggtgcaggag ctgacttctt ccaaagagtt gtggttccgg gcagcggtca      840

ttgccgtgcc cattgctgga gggctgattt tagtgttgct tattatgttg gccctgagga      900

tgcttcgaag tgaaaataag aggctgcagg atcagcggca acagatgctc tcccgtttgc      960

actacagctt tcacggacac cattccaaaa aggggcaggt tgcaaagtta gacttggaat     1020

gcatggtgcc ggtcagtggg cacgagaact gctgtctgac ctgtgataaa atgagacaag     1080

cagacctcag caacgataag atcctctcgc ttgttcactg gggcatgtac agtgggcacg     1140

ggaagctgga attcgtatga cggagtctta tctgaactac acttactgaa cagcttgaag     1200

gccttttgag ttctgctgga caggagcact ttatctgaag acaaactcat ttaatcatct     1260

ttgagagaca aaatgacctc tgcaaacaga atcttggata tttcttctga aggattattt     1320

gcacagactt aaatacagtt aaatgtgtta tttgctttta aaattataaa aagcaaagag     1380

aagactttgt acacactgtc accagggtta tttgcatcca agggagctgg aattgagtac     1440

ctaaataaac aaaaatgtgc cctatgtaag cttctacatc ttgatttatt gtaaagattt     1500

aaaagaaata tatatatttt gtctgaaatt taatagtgtc tttcataaat ttaactggga     1560

aacgtgagac agtacatgtt aattatacaa atggccattt gctgttaata atttgttctc     1620

aactctagga tgtggcttgg tttttttttt tctcttttct tttttaaaca agaccaagat     1680

cttgcttatt c                                                          1691


<210>  48
<211>  260
<212>  PRT
<213>  Homo sapiens

<400>  48

Met Asp Arg His Ser Ser Tyr Ile Phe Ile Trp Leu Gln Leu Glu Leu 
1               5                   10                  15      


Cys Ala Met Ala Val Leu Leu Thr Lys Gly Glu Ile Arg Cys Tyr Cys 
            20                  25                  30          


Asp Ala Ala His Cys Val Ala Thr Gly Tyr Met Cys Lys Ser Glu Leu 
        35                  40                  45              


Ser Ala Cys Phe Ser Arg Leu Leu Asp Pro Gln Asn Ser Asn Ser Pro 
    50                  55                  60                  


Leu Thr His Gly Cys Leu Asp Ser Leu Ala Ser Thr Thr Asp Ile Cys 
65                  70                  75                  80  


Gln Ala Lys Gln Ala Arg Asn His Ser Gly Thr Thr Ile Pro Thr Leu 
                85                  90                  95      


Glu Cys Cys His Glu Asp Met Cys Asn Tyr Arg Gly Leu His Asp Val 
            100                 105                 110         


Leu Ser Pro Pro Arg Gly Glu Ala Ser Gly Gln Gly Asn Arg Tyr Gln 
        115                 120                 125             


His Asp Gly Ser Arg Asn Leu Ile Thr Lys Val Gln Glu Leu Thr Ser 
    130                 135                 140                 


Ser Lys Glu Leu Trp Phe Arg Ala Ala Val Ile Ala Val Pro Ile Ala 
145                 150                 155                 160 


Gly Gly Leu Ile Leu Val Leu Leu Ile Met Leu Ala Leu Arg Met Leu 
                165                 170                 175     


Arg Ser Glu Asn Lys Arg Leu Gln Asp Gln Arg Gln Gln Met Leu Ser 
            180                 185                 190         


Arg Leu His Tyr Ser Phe His Gly His His Ser Lys Lys Gly Gln Val 
        195                 200                 205             


Ala Lys Leu Asp Leu Glu Cys Met Val Pro Val Ser Gly His Glu Asn 
    210                 215                 220                 


Cys Cys Leu Thr Cys Asp Lys Met Arg Gln Ala Asp Leu Ser Asn Asp 
225                 230                 235                 240 


Lys Ile Leu Ser Leu Val His Trp Gly Met Tyr Ser Gly His Gly Lys 
                245                 250                 255     


Leu Glu Phe Val 
            260 


<210>  49
<211>  3490
<212>  DNA
<213>  Homo sapiens

<400>  49
actgggtaga atacttgggg tgccagggag gcattaatgc gagaggagtc aggtgctcag       60

tttttattgg agttgggagg gcagccccac atcaggaaga gaacctgttt ctgcaggatg      120

gtccggggag aagggaggac tccacccagg cttgtgtttg ccctgctctg tgtattcagc      180

cagcaggctc tgcacaagga agcaaagtgc agggagccag gctccaccga cagccaggca      240

ctgggcagca cgcactggag acccaggacc ctgtgcagga gcagctccgg gtgacacgag      300

gggactgaag atactcccac aggggctcag caggagcaat gggtaaccaa atgagtgttc      360

cccaaagagt tgaagaccaa gagaatgaac cagaagcaga gacttaccag gacaacgcgt      420

ctgctctgaa cggggttcca gtggtggtgt cgacccacac agttcagcac ttagaggaag      480

tcgacttggg aataagtgtc aagacggata atgtggccac ttcttccccc gagacaacgg      540

agataagtgc tgttgcggat gccaacggaa agaatcttgg gaaagaggcc aaacccgagg      600

caccagctgc taaatctcgt tttttcttga tgctctctcg gcctgtacca ggacgtaccg      660

gagaccaagc cgcagattca tcccttggat cagtgaagct tgatgtcagc tccaataaag      720

ctccagcgaa caaagaccca agtgagagct ggacacttcc ggtggcagct ggaccggggc      780

aggacacaga taaaacccca gggcacgccc cggcccaaga caaggtcctc tctgccgcca      840

gggatcccac gcttctccca cctgagacag ggggagcagg aggagaagct ccctccaagc      900

ccaaggactc cagctttttt gacaaattct tcaagctgga caagggacag gaaaaggtgc      960

caggtgacag ccaacaggaa gccaagaggg cagagcatca agacaaggtg gatgaggttc     1020

ctggcttatc agggcagtcc gatgatgtcc ctgcagggaa ggacatagtt gacggcaagg     1080

aaaaagaagg acaagaactt ggaactgcgg attgctctgt ccctggggac ccagaaggac     1140

tggagactgc aaaggacgat tcccaggcag cagctatagc agagaataat aattccatca     1200

tgagtttctt taaaactctg gtttcaccta acaaagctga aacaaaaaag gacccagaag     1260

acacgggtgc tgaaaagtca cccaccactt cagctgacct taagtcagac aaagccaact     1320

ttacatccca ggagacccaa ggggctggca agaattccaa aggatgcaac ccatcggggc     1380

acacacagtc cgtgacaacc cctgaacctg cgaaggaagg caccaaggag aaatcaggac     1440

ccacctctct gcctctgggc aaactgtttt ggaaaaagtc agttaaagag gactcagtcc     1500

ccacaggtgc ggaggagaat gtggtgtgtg agtcaccagt agagattata aagtccaagg     1560

aagtagaatc agccttacaa acagtggacc tcaacgaagg agatgctgca cctgaaccca     1620

cagaagcgaa actcaaaaga gaagaaagca aaccaagaac ctctctgatg gcgtttctca     1680

gacaaatgtc agtgaaaggg gatggaggga tcacccactc agaagaaata aatgggaaag     1740

actccagctg ccaaacatca gactccacag aaaagactat cacaccgcca gagcctgaac     1800

caacaggagc accacagaag ggtaaagagg gctcctcgaa ggacaagaag tcagcagccg     1860

agatgaacaa gcagaagagc aacaagcagg aagccaaaga accagcccag tgcacagagc     1920

aggccacggt ggacacgaac tcactgcaga atggggacaa gctccaaaag agacctgaga     1980

agcggcagca gtcccttggg ggcttcttta aaggcctggg accaaagcgg atgttggatg     2040

ctcaagtgca aacagaccca gtatccatcg gaccagttgg caaatccaag taaacaaatc     2100

agcacggttc ccaccaggtt ctcctgccac caagatgtgt tctccttact ccatctcctc     2160

cccaaacacg ctccatgtat atattcttct gatggccagc aaatgaaatt ctgcctagaa     2220

attaagcccg agctgttgta tattgaggtg tattatttac gtctctggtc cagtcttttc     2280

tggcaaataa cagtaaagat ggtttagcag gtcacctagt tgggtcagaa gagtcgatga     2340

tcaccaagca ggaaagggag ggaatagagg aatgtgttcg ggttaagtga tgaaaatggc     2400

agtggtggcc gggcgtggtg gctctcgcct gtaatctcag cactttggga ggccgaggca     2460

ggtggatcac ctgaggtcag gagttcaaga ctagcctggc caacatcatg aaaccccgtc     2520

tctactaaaa atacaaaaat tagccaggca tggtggcaca cacctgtagt cccagctact     2580

cgggagccca acgcacgaga accgcttgta cccaggaggt ggaggttgca gtgagccgaa     2640

gttgcaccat tgcactccac cctgggcgac agagcaagat tctatcaaaa aaaaaaaaag     2700

gcagtggcaa gtaagttata gaagagaaat gctgctagaa ggaattaagc gttgtagtaa     2760

atgcgtgctt atcctctaag cttgaagaag ggagacgaaa atccatttgt ttaaattcac     2820

atctcaagga gggagaaccc gggctgtgtt gggtggttgc caatttccta gaacggaatg     2880

tgtggggtat agaaaaagga atgaataagc gttgtttttc aaatagggtc cttgtaagtt     2940

attgatgaga gggaaaagat tgactgggga gggcttaaaa tgatttggga aaacaattgc     3000

ttttgaggct cagtgacaac ggcaaagatt acaacttaaa aaaaaaaaat aaataaaaaa     3060

taaaggaagt tgcacggtta ttttgcaaca caagggggcg gcaaggtccc catttttatc     3120

ctgtaatact gtatccctaa caaagatttg gtctctgcta tcttacatta ttaatgtttc     3180

tcagatggct gaggggctcg cttcatctgt tccgtctgac acttatctca agtgtgtctg     3240

tcattcctaa tgttctcagg atgtgctctg ataaaaccct ccccataacc tcagttaata     3300

aaaatttaca gaagacttct caaatacctg agttgttttt aatacctgta caaaggagta     3360

aataggaccc tgagtctatt aaaatgtaat tcaaagtagc atatgattga ctgacagtca     3420

tgtaaactgt atctttcttt ttctgattta ataaaaaata catttacttc taaagtaaaa     3480

aaaaaaaaaa                                                            3490


<210>  50
<211>  584
<212>  PRT
<213>  Homo sapiens

<400>  50

Met Gly Asn Gln Met Ser Val Pro Gln Arg Val Glu Asp Gln Glu Asn 
1               5                   10                  15      


Glu Pro Glu Ala Glu Thr Tyr Gln Asp Asn Ala Ser Ala Leu Asn Gly 
            20                  25                  30          


Val Pro Val Val Val Ser Thr His Thr Val Gln His Leu Glu Glu Val 
        35                  40                  45              


Asp Leu Gly Ile Ser Val Lys Thr Asp Asn Val Ala Thr Ser Ser Pro 
    50                  55                  60                  


Glu Thr Thr Glu Ile Ser Ala Val Ala Asp Ala Asn Gly Lys Asn Leu 
65                  70                  75                  80  


Gly Lys Glu Ala Lys Pro Glu Ala Pro Ala Ala Lys Ser Arg Phe Phe 
                85                  90                  95      


Leu Met Leu Ser Arg Pro Val Pro Gly Arg Thr Gly Asp Gln Ala Ala 
            100                 105                 110         


Asp Ser Ser Leu Gly Ser Val Lys Leu Asp Val Ser Ser Asn Lys Ala 
        115                 120                 125             


Pro Ala Asn Lys Asp Pro Ser Glu Ser Trp Thr Leu Pro Val Ala Ala 
    130                 135                 140                 


Gly Pro Gly Gln Asp Thr Asp Lys Thr Pro Gly His Ala Pro Ala Gln 
145                 150                 155                 160 


Asp Lys Val Leu Ser Ala Ala Arg Asp Pro Thr Leu Leu Pro Pro Glu 
                165                 170                 175     


Thr Gly Gly Ala Gly Gly Glu Ala Pro Ser Lys Pro Lys Asp Ser Ser 
            180                 185                 190         


Phe Phe Asp Lys Phe Phe Lys Leu Asp Lys Gly Gln Glu Lys Val Pro 
        195                 200                 205             


Gly Asp Ser Gln Gln Glu Ala Lys Arg Ala Glu His Gln Asp Lys Val 
    210                 215                 220                 


Asp Glu Val Pro Gly Leu Ser Gly Gln Ser Asp Asp Val Pro Ala Gly 
225                 230                 235                 240 


Lys Asp Ile Val Asp Gly Lys Glu Lys Glu Gly Gln Glu Leu Gly Thr 
                245                 250                 255     


Ala Asp Cys Ser Val Pro Gly Asp Pro Glu Gly Leu Glu Thr Ala Lys 
            260                 265                 270         


Asp Asp Ser Gln Ala Ala Ala Ile Ala Glu Asn Asn Asn Ser Ile Met 
        275                 280                 285             


Ser Phe Phe Lys Thr Leu Val Ser Pro Asn Lys Ala Glu Thr Lys Lys 
    290                 295                 300                 


Asp Pro Glu Asp Thr Gly Ala Glu Lys Ser Pro Thr Thr Ser Ala Asp 
305                 310                 315                 320 


Leu Lys Ser Asp Lys Ala Asn Phe Thr Ser Gln Glu Thr Gln Gly Ala 
                325                 330                 335     


Gly Lys Asn Ser Lys Gly Cys Asn Pro Ser Gly His Thr Gln Ser Val 
            340                 345                 350         


Thr Thr Pro Glu Pro Ala Lys Glu Gly Thr Lys Glu Lys Ser Gly Pro 
        355                 360                 365             


Thr Ser Leu Pro Leu Gly Lys Leu Phe Trp Lys Lys Ser Val Lys Glu 
    370                 375                 380                 


Asp Ser Val Pro Thr Gly Ala Glu Glu Asn Val Val Cys Glu Ser Pro 
385                 390                 395                 400 


Val Glu Ile Ile Lys Ser Lys Glu Val Glu Ser Ala Leu Gln Thr Val 
                405                 410                 415     


Asp Leu Asn Glu Gly Asp Ala Ala Pro Glu Pro Thr Glu Ala Lys Leu 
            420                 425                 430         


Lys Arg Glu Glu Ser Lys Pro Arg Thr Ser Leu Met Ala Phe Leu Arg 
        435                 440                 445             


Gln Met Ser Val Lys Gly Asp Gly Gly Ile Thr His Ser Glu Glu Ile 
    450                 455                 460                 


Asn Gly Lys Asp Ser Ser Cys Gln Thr Ser Asp Ser Thr Glu Lys Thr 
465                 470                 475                 480 


Ile Thr Pro Pro Glu Pro Glu Pro Thr Gly Ala Pro Gln Lys Gly Lys 
                485                 490                 495     


Glu Gly Ser Ser Lys Asp Lys Lys Ser Ala Ala Glu Met Asn Lys Gln 
            500                 505                 510         


Lys Ser Asn Lys Gln Glu Ala Lys Glu Pro Ala Gln Cys Thr Glu Gln 
        515                 520                 525             


Ala Thr Val Asp Thr Asn Ser Leu Gln Asn Gly Asp Lys Leu Gln Lys 
    530                 535                 540                 


Arg Pro Glu Lys Arg Gln Gln Ser Leu Gly Gly Phe Phe Lys Gly Leu 
545                 550                 555                 560 


Gly Pro Lys Arg Met Leu Asp Ala Gln Val Gln Thr Asp Pro Val Ser 
                565                 570                 575     


Ile Gly Pro Val Gly Lys Ser Lys 
            580                 


<210>  51
<211>  2767
<212>  DNA
<213>  Homo sapiens

<400>  51
cgccgtgggt ttctttgttc gtggtgggga ctgtgggctt tgaggaggtt ggtaccatgc       60

gagtgcctcg gtgctgcctg ctcctcatcc gctggagcga ccagggtgct gccctcagcc      120

ccagccccgg ggggagctgg cgcccgcgat ggacagatag atgctcgtgg ggtggaagga      180

ggttgcgact aggttaaggg cagtctccgc ctcggtgccc cccgcccccg ctcgtgttgt      240

cacggggact tgctggcgtg gtgcttctcg aattgacagc cccggggctc tgcagagttg      300

tggggccccg gcatcagtgg gtggacgggt gttgtcccta cgggcgcggg gcgggcgggc      360

tggactggac ttctctcccc ggaccgtagc cgggtgtgcc gcgccacccc agggctcctg      420

ggacgggggt atccgcctct cggatgaagg atttgggggc agagcacttg gcaggtcatg      480

aaggggtcca acttctcggg ttgttgaacg tctacctgga acaagaagag agattccaac      540

ctcgagaaaa agggctgagt ttgattgagg ctaccccgga gaatgataac actttgtgtc      600

caggattgag aaatgccaaa gttgaagatt taaggagttt agccaacttt tttggatctt      660

gcactgaaac ttttgtcctg gctgtcaata ttttggacag gttcttggct cttatgaagg      720

tgaaacctaa acatttgtct tgcattggag tctgttcttt tttgctggct gctagaatag      780

ttgaagaaga ctgcaatatt ccatccactc atgatgtgat ccggattagt cagtgtaaat      840

gtactgcttc tgacataaaa cggatggaaa aaataatttc agaaaaattg cactatgaat      900

tggaagctac tactgcctta aactttttgc acttatacca tactattata ctttgtcata      960

cttcagaaag gaaagaaata ctgagccttg ataaactaga agctcagctg aaagcttgca     1020

actgccgact catcttttca aaagcaaaac catctgtatt agccttgtgc cttctcaatt     1080

tggaagtgga aactttgaaa tctgttgaat tactggaaat tctcttgcta gttaaaaaac     1140

attccaagat taatgacact gagttcttct actggagaga gttggtttct aaatgcctag     1200

ccgagtattc ttctcctgaa tgttgcaaac cagatcttaa gaagttggtt tggatcgttt     1260

caaggcgcac agcccagaac ctccacaaca gctactatag tgttcctgag ctgccaacga     1320

tacctgaggg gggttgtttt gatgaaagtg aaagtgagga ctcttgtgaa gatatgagtt     1380

gtggagagga gagtctcagc agctctcctc ccagtgatca agagtgcacc ttctttttca     1440

acttcaaagt ggcacaaaca ctgtgctttc catcttagaa atctgattgt tctgtcagaa     1500

tttatattta caggtttcaa agcaataaat gggggaatag gtagtttcct ggtttagccc     1560

ccatctagtc aggaattaat atactggaat acctaccttc tatttgttat tcagatcaga     1620

tctggcctat tttcatattt atcctaagcc atcaaatggg gtagtgcctc ttaaaccatt     1680

aacagtactt tagacattgg cactttattt ttctcgtaga tctttagcta ctttggggag     1740

gagggaaggt gctgatacct tcaatttgtt acttttcaag atttttaaaa ataactagtg     1800

tagcttatct taaacatttt ataaaacctt cagatgtctt taagcagatt ggaagtatgc     1860

aagtgcttcc ttagcaggga cagtggataa tccttaatgg tttatcatag atttcaccct     1920

ccccccttct cagaagagtg agtatgctct taaatgtcaa acacattttt gttgttttgt     1980

tttttaaatg atcagtgtct atttgatgtg atgcagatct tataaatttg ggaattataa     2040

tattgacatt tctgtgattt ttatatatgt aatgtcttaa ttgagatttc tgttaaggca     2100

gaaataatta ggctagggct cttagttttc attcctattg cccaagtatt gtcaaactat     2160

ggtattattt taatgttact ttaaaaatcc ataatctgct agttttgcat gtacttatat     2220

gaaaacagtg cagtaagttg aaaactcagt atctatggaa ttgataaatg ttgatctggt     2280

gtagtatatt ttatcgcatt ttcttatatt aaaaaatgtc tgcatgatta cattttattt     2340

cctttgtaat ttacatttca gaatagtgta ttgctatatg ggtgccaaga ttgaatatga     2400

agaacccgag tgtttgtagt attatagttt taagcaaatc tgtgtggtga tacagccata     2460

agaatggggc ttatataaac tctgtacatg taagattttg tacagagaat ttttaacttt     2520

ataaattgta tatgaacatg taaatctttt aaaatgtaca taaaatactg tattttttta     2580

ccttgtgtgt gatagtctag tcattgcatg taaatataat ttattatgta ttctgtagta     2640

taaatcatac attgatgact tacattttta ctggtaagtc aacatccgtt ggatgttttc     2700

tgaagtggct ctttttgaag tgataataga ttgtaattca aaataaaatt attaatgaat     2760

tctcctt                                                               2767


<210>  52
<211>  344
<212>  PRT
<213>  Homo sapiens

<400>  52

Met Lys Asp Leu Gly Ala Glu His Leu Ala Gly His Glu Gly Val Gln 
1               5                   10                  15      


Leu Leu Gly Leu Leu Asn Val Tyr Leu Glu Gln Glu Glu Arg Phe Gln 
            20                  25                  30          


Pro Arg Glu Lys Gly Leu Ser Leu Ile Glu Ala Thr Pro Glu Asn Asp 
        35                  40                  45              


Asn Thr Leu Cys Pro Gly Leu Arg Asn Ala Lys Val Glu Asp Leu Arg 
    50                  55                  60                  


Ser Leu Ala Asn Phe Phe Gly Ser Cys Thr Glu Thr Phe Val Leu Ala 
65                  70                  75                  80  


Val Asn Ile Leu Asp Arg Phe Leu Ala Leu Met Lys Val Lys Pro Lys 
                85                  90                  95      


His Leu Ser Cys Ile Gly Val Cys Ser Phe Leu Leu Ala Ala Arg Ile 
            100                 105                 110         


Val Glu Glu Asp Cys Asn Ile Pro Ser Thr His Asp Val Ile Arg Ile 
        115                 120                 125             


Ser Gln Cys Lys Cys Thr Ala Ser Asp Ile Lys Arg Met Glu Lys Ile 
    130                 135                 140                 


Ile Ser Glu Lys Leu His Tyr Glu Leu Glu Ala Thr Thr Ala Leu Asn 
145                 150                 155                 160 


Phe Leu His Leu Tyr His Thr Ile Ile Leu Cys His Thr Ser Glu Arg 
                165                 170                 175     


Lys Glu Ile Leu Ser Leu Asp Lys Leu Glu Ala Gln Leu Lys Ala Cys 
            180                 185                 190         


Asn Cys Arg Leu Ile Phe Ser Lys Ala Lys Pro Ser Val Leu Ala Leu 
        195                 200                 205             


Cys Leu Leu Asn Leu Glu Val Glu Thr Leu Lys Ser Val Glu Leu Leu 
    210                 215                 220                 


Glu Ile Leu Leu Leu Val Lys Lys His Ser Lys Ile Asn Asp Thr Glu 
225                 230                 235                 240 


Phe Phe Tyr Trp Arg Glu Leu Val Ser Lys Cys Leu Ala Glu Tyr Ser 
                245                 250                 255     


Ser Pro Glu Cys Cys Lys Pro Asp Leu Lys Lys Leu Val Trp Ile Val 
            260                 265                 270         


Ser Arg Arg Thr Ala Gln Asn Leu His Asn Ser Tyr Tyr Ser Val Pro 
        275                 280                 285             


Glu Leu Pro Thr Ile Pro Glu Gly Gly Cys Phe Asp Glu Ser Glu Ser 
    290                 295                 300                 


Glu Asp Ser Cys Glu Asp Met Ser Cys Gly Glu Glu Ser Leu Ser Ser 
305                 310                 315                 320 


Ser Pro Pro Ser Asp Gln Glu Cys Thr Phe Phe Phe Asn Phe Lys Val 
                325                 330                 335     


Ala Gln Thr Leu Cys Phe Pro Ser 
            340                 


<210>  53
<211>  1744
<212>  DNA
<213>  Homo sapiens

<400>  53
gcagcaggcc aagggggagg tgcgagcgtg gacctgggac gggtctgggc ggctctcggt       60

ggttggcacg ggttcgcaca cccattcaag cggcaggacg cacttgtctt agcagttctc      120

gctgaccgcg ctagctgcgg cttctacgct ccggcactct gagttcatca gcaaacgccc      180

tggcgtctgt cctcaccatg cctagccttt gggaccgctt ctcgtcgtcg tccacctcct      240

cttcgccctc gtccttgccc cgaactccca ccccagatcg gccgccgcgc tcagcctggg      300

ggtcggcgac ccgggaggag gggtttgacc gctccacgag cctggagagc tcggactgcg      360

agtccctgga cagcagcaac agtggcttcg ggccggagga agacacggct tacctggatg      420

gggtgtcgtt gcccgacttc gagctgctca gtgaccctga ggatgaacac ttgtgtgcca      480

acctgatgca gctgctgcag gagagcctgg cccaggcgcg gctgggctct cgacgccctg      540

cgcgcctgct gatgcctagc cagttggtaa gccaggtggg caaagaacta ctgcgcctgg      600

cctacagcga gccgtgcggc ctgcgggggg cgctgctgga cgtctgcgtg gagcagggca      660

agagctgcca cagcgtgggc cagctggcac tcgaccccag cctggtgccc accttccagc      720

tgaccctcgt gctgcgcctg gactcacgac tctggcccaa gatccagggg ctgtttagct      780

ccgccaactc tcccttcctc cctggcttca gccagtccct gacgctgagc actggcttcc      840

gagtcatcaa gaagaagctg tacagctcgg aacagctgct cattgaggag tgttgaactt      900

caacctgagg gggccgacag tgccctccaa gacagagacg actgaacttt tggggtggag      960

actagaggca ggagctgagg gactgattcc tgtggttgga aaactgaggc agccacctaa     1020

ggtggaggtg ggggaatagt gtttcccagg aagctcattg agttgtgtgc gggtggctgt     1080

gcattgggga cacatacccc tcagtactgt agcatgaaac aaaggcttag gggccaacaa     1140

ggcttccagc tggatgtgtg tgtagcatgt accttattat ttttgttact gacagttaac     1200

agtggtgtga catccagaga gcagctgggc tgctcccgcc ccagcccggc ccagggtgaa     1260

ggaagaggca cgtgctcctc agagcagccg gagggagggg ggaggtcgga ggtcgtggag     1320

gtggtttgtg tatcttactg gtctgaaggg accaagtgtg tttgttgttt gttttgtatc     1380

ttgtttttct gatcggagca tcactactga cctgttgtag gcagctatct tacagacgca     1440

tgaatgtaag agtaggaagg ggtgggtgtc agggatcact tgggatcttt gacacttgaa     1500

aaattacacc tggcagctgc gtttaagcct tcccccatcg tgtactgcag agttgagctg     1560

gcaggggagg ggctgagagg gtgggggctg gaacccctcc ccgggaggag tgccatctgg     1620

gtcttccatc tagaactgtt tacatgaaga taagatactc actgttcatg aatacacttg     1680

atgttcaagt attaagacct atgcaatatt ttttactttt ctaataaaca tgtttgttaa     1740

aaca                                                                  1744


<210>  54
<211>  232
<212>  PRT
<213>  Homo sapiens

<400>  54

Met Pro Ser Leu Trp Asp Arg Phe Ser Ser Ser Ser Thr Ser Ser Ser 
1               5                   10                  15      


Pro Ser Ser Leu Pro Arg Thr Pro Thr Pro Asp Arg Pro Pro Arg Ser 
            20                  25                  30          


Ala Trp Gly Ser Ala Thr Arg Glu Glu Gly Phe Asp Arg Ser Thr Ser 
        35                  40                  45              


Leu Glu Ser Ser Asp Cys Glu Ser Leu Asp Ser Ser Asn Ser Gly Phe 
    50                  55                  60                  


Gly Pro Glu Glu Asp Thr Ala Tyr Leu Asp Gly Val Ser Leu Pro Asp 
65                  70                  75                  80  


Phe Glu Leu Leu Ser Asp Pro Glu Asp Glu His Leu Cys Ala Asn Leu 
                85                  90                  95      


Met Gln Leu Leu Gln Glu Ser Leu Ala Gln Ala Arg Leu Gly Ser Arg 
            100                 105                 110         


Arg Pro Ala Arg Leu Leu Met Pro Ser Gln Leu Val Ser Gln Val Gly 
        115                 120                 125             


Lys Glu Leu Leu Arg Leu Ala Tyr Ser Glu Pro Cys Gly Leu Arg Gly 
    130                 135                 140                 


Ala Leu Leu Asp Val Cys Val Glu Gln Gly Lys Ser Cys His Ser Val 
145                 150                 155                 160 


Gly Gln Leu Ala Leu Asp Pro Ser Leu Val Pro Thr Phe Gln Leu Thr 
                165                 170                 175     


Leu Val Leu Arg Leu Asp Ser Arg Leu Trp Pro Lys Ile Gln Gly Leu 
            180                 185                 190         


Phe Ser Ser Ala Asn Ser Pro Phe Leu Pro Gly Phe Ser Gln Ser Leu 
        195                 200                 205             


Thr Leu Ser Thr Gly Phe Arg Val Ile Lys Lys Lys Leu Tyr Ser Ser 
    210                 215                 220                 


Glu Gln Leu Leu Ile Glu Glu Cys 
225                 230         


<210>  55
<211>  2722
<212>  DNA
<213>  Homo sapiens

<400>  55
gagtctggcc gcagtcgcgg cagtggtggc ttcccatccc caaaaggcgc cctccgactc       60

cttgcgccgc actgctcgcc gggccagtcc ggaaacgggt cgtggagctc cgcaccactc      120

ccgctggttc ccgaaggcag atcccttctc ccgagagttg cgagaaactt tcccttgtcc      180

ccgacgctgc agcggctcgg gtaccgtggc agccgcaggt ttctgaaccc cgggccacgc      240

tccccgcgcc tcggcttcgc gctcgtgtag atcgttccct ctctggttgc acgctgggga      300

tcccggacct cgattctgcg ggcgagatgc ccctgggaca catcatgagg ctggacctgg      360

agaaaattgc cctggagtac atcgtgccct gtctgcacga ggtgggcttc tgctacctgg      420

acaacttcct gggcgaggtg gtgggcgact gcgtcctgga gcgcgtcaag cagctgcact      480

gcaccggggc cctgcgggac ggccagctgg cggggccgcg cgccggcgtc tccaagcgac      540

acctgcgggg cgaccagatc acgtggatcg ggggcaacga ggagggctgc gaggccatca      600

gcttcctcct gtccctcatc gacaggctgg tcctctactg cgggagccgg ctgggcaaat      660

actacgtcaa ggagaggtct aaggcaatgg tggcttgcta tccgggaaat ggaacaggtt      720

atgttcgcca cgtggacaac cccaacggtg atggtcgctg catcacctgc atctactatc      780

tgaacaagaa ttgggatgcc aagctacatg gtgggatcct gcggatattt ccagagggga      840

aatcattcat agcagatgtg gagcccattt ttgacagact cctgttcttc tggtcagatc      900

gtaggaaccc acacgaagtg cagccctctt acgcaaccag atatgctatg actgtctggt      960

actttgatgc tgaagaaagg gcagaagcca aaaagaaatt caggaattta actaggaaaa     1020

ctgaatctgc cctcactgaa gactgaccgt gctctgaaat ctgctggcct tgttcatttt     1080

agtaacggtt cctgaattct cttaaattct ttgagatcca aagatggcct cttcagtgac     1140

aacaatctcc ctgctacttc ttgcatcctt cacatccctg tcttgtgtgt ggtacttcat     1200

gttttcttgc caagactgtg ttgatcttca gatactctct ttgccagatg aagttacttg     1260

ctaactccag aaattcctgc agacatccta ctcggccagc ggtttacctg atagattcgg     1320

taatactatc aagagaagag cctaggagca cagcgaggga atgaacctta cttgcacttt     1380

atgtatactt cctgatttga aaggaggagg tttgaaaaga aaaaaatgga ggtggtagat     1440

gccacagaga ggcatcacgg aagccttaac agcaggaaac agagaaattt gtgtcatctg     1500

aacaatttcc agatgttctt aatccagggc tgttggggtt tctggagaat tatcacaacc     1560

taatgacatt aatacctcta gaaagggctg ctgtcatagt gaacaattta taagtgtccc     1620

atggggcaga cactcctttt ttcccagtcc tgcaacctgg attttctgcc tcagccccat     1680

tttgctgaaa ataatgactt tctgaataaa gatggcaaca caattttttc tccattttca     1740

gttcttacct gggaacctaa ttccccagaa gctaaaaaac tagacattag ttgttttggt     1800

tgctttgttg gaatggaatt taaatttaaa tgaaaggaaa aatatatccc tggtagtttt     1860

gtgttaacca ctgataactg tggaaagagc taggtctact gatatacaat aaacatgtgt     1920

gcatcttgaa caatttgaga ggggaggtgg agttggaaat gtgggtgttc ctgttttttt     1980

tttttttttt tttttagttt tcctttttaa tgagctcacc ctttaacaca aaaaaagcaa     2040

ggtgatgtat tttaaaaaag gaagtggaaa taaaaaaatc tcaaagctat ttgagttctc     2100

gtctgtccct agcagtcttt cttcagctca cttggctctc tagatccact gtggttggca     2160

gtatgaccag aatcatggaa tttgctagaa ctgtggaagc ttctactcct gcagtaagca     2220

cagatcgcac tgcctcaata acttggtatt gagcacgtat tttgcaaaag ctacttttcc     2280

tagttttcag tattactttc atgttttaaa aatcccttta atttcttgct tgaaaatccc     2340

atgaacatta aagagccaga aatattttcc tttgttatgt acggatatat atatatatag     2400

tcttccaaga tagaagttta ctttttcctc ttctggtttt ggaaaatttc cagataagac     2460

atgtcaccat taattctcaa cgactgctct attttgttgt acggtaatag ttatcacctt     2520

ctaaattact atgtaattta ttcacttatt atgtttattg tcttgtatcc tttctctgga     2580

gtgtaagcac aatgaagaca ggaattttgt atatttttaa ccaatgcaac atactctcag     2640

cacctaaaat agtgccggga acatagtaag ggctcagtaa atacttgttg aataaactca     2700

gtctcctaca ttagcattct aa                                              2722


<210>  56
<211>  239
<212>  PRT
<213>  Homo sapiens

<400>  56

Met Pro Leu Gly His Ile Met Arg Leu Asp Leu Glu Lys Ile Ala Leu 
1               5                   10                  15      


Glu Tyr Ile Val Pro Cys Leu His Glu Val Gly Phe Cys Tyr Leu Asp 
            20                  25                  30          


Asn Phe Leu Gly Glu Val Val Gly Asp Cys Val Leu Glu Arg Val Lys 
        35                  40                  45              


Gln Leu His Cys Thr Gly Ala Leu Arg Asp Gly Gln Leu Ala Gly Pro 
    50                  55                  60                  


Arg Ala Gly Val Ser Lys Arg His Leu Arg Gly Asp Gln Ile Thr Trp 
65                  70                  75                  80  


Ile Gly Gly Asn Glu Glu Gly Cys Glu Ala Ile Ser Phe Leu Leu Ser 
                85                  90                  95      


Leu Ile Asp Arg Leu Val Leu Tyr Cys Gly Ser Arg Leu Gly Lys Tyr 
            100                 105                 110         


Tyr Val Lys Glu Arg Ser Lys Ala Met Val Ala Cys Tyr Pro Gly Asn 
        115                 120                 125             


Gly Thr Gly Tyr Val Arg His Val Asp Asn Pro Asn Gly Asp Gly Arg 
    130                 135                 140                 


Cys Ile Thr Cys Ile Tyr Tyr Leu Asn Lys Asn Trp Asp Ala Lys Leu 
145                 150                 155                 160 


His Gly Gly Ile Leu Arg Ile Phe Pro Glu Gly Lys Ser Phe Ile Ala 
                165                 170                 175     


Asp Val Glu Pro Ile Phe Asp Arg Leu Leu Phe Phe Trp Ser Asp Arg 
            180                 185                 190         


Arg Asn Pro His Glu Val Gln Pro Ser Tyr Ala Thr Arg Tyr Ala Met 
        195                 200                 205             


Thr Val Trp Tyr Phe Asp Ala Glu Glu Arg Ala Glu Ala Lys Lys Lys 
    210                 215                 220                 


Phe Arg Asn Leu Thr Arg Lys Thr Glu Ser Ala Leu Thr Glu Asp 
225                 230                 235                 


<210>  57
<211>  5731
<212>  DNA
<213>  Homo sapiens

<400>  57
gcagattgcg cgagggggag cgagcgagcg ggcgctgcca ggagcccgca gccctggcgc       60

ccgccgccgc ccggagcccc gcaatatgcc gccgcggccc tctggctcta ggccatggcg      120

aggctctgcc ggcgtgtccc ctgcaccctg cttctcggcc tggccgtggt gctgctgaaa      180

gcgcggctgg tccccgcggc cgccagagcg gaactcagcc gctccgacct cagcctcatc      240

caacagcagc agcagcagca gcaacaacaa caacaacagc aaaagcagct ggaggaggct      300

gaggaggaga ggacagaggt gcctggggca acctccacct tgacggttcc agtgtctgta      360

tttatgttga aagtccaggt gaatgacatc atcagtcgtc agtacctgag ccaagcagtt      420

gtagaagtgt ttgtaaacta cacgaagaca aattccacag taactaaaag caatggagca      480

gtgctgataa aagtacccta caaattagga cttagtttaa ctattattgc ttacaaagat      540

ggctacgtgt tgacccctct gccttggaaa accagaagaa tgccaatata ttcatcagtt      600

acactttcac tgttcccgca aagccaagca aatatatggc tatttgaaga cactgtttta      660

attactggaa aattagctga tgccaagtct caaccaagtg ttcagttttc aaaagcctta      720

attaaacttc ctgacaacca tcatattagc aacgttactg gctatcttac agttctacaa      780

cagtttttga aagtggacaa ttttctgcat acaactggaa ttactctcaa taaaccaggt      840

tttgaaaaca ttgaattgac tcctcttgct gcaatatgtg tgaaaatata ttctggagga      900

aaagaactaa aggtcaatgg ctctattcaa gtttctcttc ctcttctacg tctgaatgat      960

ataagtgcag gggatcgcat acctgcttgg acatttgata tgaacacagg tgcttgggta     1020

aatcatggtc ggggaatggt caaggaacat aacaatcatt taatctggac atatgatgca     1080

ccacatttgg ggtactggat agcagctcca cttccaggaa ctagaggttc aggtataaat     1140

gaagattcca aggacataac tgcctaccac acagtgtttc ttacagccat attaggagga     1200

acaatagtca ttgtcattgg attttttgct gtactacttt gttattgcag ggacaagtgt     1260

ggtactccac agaaaagaga aagaaatatc actaaacttg aggtcctcaa gagagaccag     1320

acaacttcaa caacacacat aaatcatatc agtacagtta aagttgcatt aaaagctgag     1380

gacaagtcgc agttattcaa tgccaaaaac tcctcatata gtcctcagaa aaaggaacca     1440

tcaaaggcag aaacagaaga aagagtttcc atggtaaaaa ctcgggacga ttttaaaatc     1500

tacaatgaag atgtttcatt tctatcagtc aatcaaaata attactcaag aaacccaaca     1560

cagtctttgg agcccaatgt agggtccaaa caacctaaac atattaacaa caatctatct     1620

tcatctctag gtgatgctca agatgaaaag aggtatctca caggtaatga ggaggcgtat     1680

gggcgttccc atattcctga acagcttatg catatttaca gccaacccat tgccatcctt     1740

caaacatctg accttttctc cacaccggaa caattacata ctgctaagtc agctactttg     1800

ccaagaaagg gacagttagt ctatggccaa ttgatggaac cagtaaatcg agagaacttt     1860

acgcagacct tgcccaaaat gccaattcat tctcatgcac agcccccaga tgccagggaa     1920

gaggatatca tacttgaagg tcaacagagc ctgccatccc aggcttcaga ttggagccga     1980

tactcaagca gcttactgga atccgtctct gttcctggaa cactaaatga ggctgttgta     2040

atgactccat tttcatcgga acttcaagga atttcagaac agaccctcct ggagctgtcc     2100

aaaggaaagc cctccccgca tcccagagcc tggtttgtgt ctcttgatgg aaagccagtt     2160

gcacaagtga ggcactcctt tatagacctg aaaaagggca agagaaccca gagcaatgac     2220

accagtctgg actctggggt ggacatgaat gagcttcact caagtagaaa gctcgagagg     2280

gagaaaacat tcatcaaaag catgcatcag cccaagatcc tttacttaga agatttagac     2340

ctaagcagca gtgagagtgg aaccaccgtc tgttcccctg aggacccagc tttaaggcac     2400

atcctagatg gagggagtgg agtgatcatg gagcaccctg gagaagagtc gccaggaagg     2460

aaaagcactg ttgaagattt tgaagctaat acatccccca ctaaaagaag gggcagacca     2520

ccactagcca aaagagatag caagactaac atctggaaga agcgagagga acgcccactg     2580

attcccataa attaactcca atggggattg tgtgtctgct gtctcgtgct gtttattctt     2640

gcttcttgtt gtaaattgca gtacgaactt aagaaaatga gactgagcaa tctcatggtt     2700

cttggacatg tctcaagcag agtaaatggt aattcagtaa tcagagagaa agataccaag     2760

gaatgctttt tctggcctat tcatttattt ttgggtgatg aatttacagt atctaagttt     2820

tcaaaatgta aaatagcttc aagatgttag ttatctgaaa atgttgctca gccagccagt     2880

ttggccttga ctctcttaag aataacagtg aaatatatac tcctcaagtt gcctccaaaa     2940

atgttgcctc taccatggtg actaccccat ggaacattta gaaacaaaac tgacttcagg     3000

catcatatta ttttaaatgt tactattacg tcttcttctg cctatactta aaaataactt     3060

gataaatgac ttggactgat gttactctgg agttatcaca aagaaaatgt tgtttggtct     3120

ttaaagagca tgtgtattgt atcatcccaa acgtaaatcc tacatttata taagatgggc     3180

aagaagctac ttggtcatta gagagggaga caccagctct ttggttgttt ttggatataa     3240

ctttacaaaa taagtaagat gttaatttag aaatttgaga aattaatgct ctaatactga     3300

gtttttattt aaaaattatt ttttcttccc ctcaacaatg aagcaagctt agctgtcaag     3360

ggaaactttt tacaaatctg aaaaaaacaa tctatgactt tggtttaagg ctcactgata     3420

cttttaggct aaattggttt taatatattt cttctattct aaaaacctga actcagtcac     3480

ttaaaggcta tgaaatttaa aaaaaaagtc gatgtgaaag tttcttttga acactaaaat     3540

aaaatatgtg cagataaaat atacattgat ttgtttttct taaatgttga tgagaagaaa     3600

aagagatgcc attttcctga ggctcaaaaa taccttcagg atagttgtat atccagttat     3660

tgattttctt aaaagatgtg taaggaaaac agtttcaatt tcaggggaaa agtaaaagtt     3720

tttccctaag tcacttaaag cctttgcaac ttcttttttc agttttgtaa gtaatatatc     3780

tatgttcttt tcattatagc aagcattcaa tgtgaacaac tttttaatta actctgaatt     3840

accattcata catcctaaaa ataaaagctc gttattcatt aaaatcaact gatcccattt     3900

ttcttaaaat ttccctgaag gcaaatgtct gaagcacctt tcccttgtgg gggtaaaaat     3960

cctaaattgc tttatttttc attccctcct attcaacatg ggagcagcat agagacccaa     4020

accatgtaaa caagttcagt gaaccaaaac agccacatta gcttcagtaa aattatagct     4080

agatgtgcaa ttttttcctc caacttctaa cgtgtcaaat aaccttccta ctgttctgtg     4140

ttaactgaaa gaacataaag accctaggca aatatttgct atatattacc ccaatccata     4200

gaagaaataa tgttttgggt aatacctagg cttccttttt tttttttttt tttttttttt     4260

agtgataagg ctcataacaa ttaattagag aaggcttctt attggtctta cacagaaaga     4320

tacatcaaaa gcagcatgac tcaaaatgat ttggaaaagg ttaaagttag tgctctgctg     4380

aagtgccttt gatatagact tgcattatta gaaggatata acatcttttt taagtgtgca     4440

ttttctttca gttaaccaaa ttaaacagat gtgcagtttt attaaaaata tagacctagt     4500

gtttcatgtt ggaacaataa atattgcatg tgagtagtat ttcttgtttt ttgaatacag     4560

tatatattga taaattgttt atgttggaat gaagttagaa actatatagc aaaacattat     4620

attttaagtg tttatttttc ccacctttaa ataaaaatgt ttcatctcag cttggtaatg     4680

aaatacacat attggtataa gggtatacca ttcaggtatg ccacttattt tattcatttt     4740

tgtgtaaggg aaatgagatg atgtatccca agggcttttc tagaactact tgtttgcttt     4800

cagaataaaa ccttattatt ttttacactg cacatgctgt tctcaattgg taattatagg     4860

caatttatct tttctaatga tcaaaagagt gtgacttctc atttgtgagt agttcacaaa     4920

tttcctgtta aaaagctgaa accatctact ttttcttaac ccaagtgata ataaacaata     4980

ttcacaactt tcttaaattt ttaaattgaa aaccaaggtt ttttcaaata taaacctaga     5040

tgattttggt cacaaattgt taacatttgt cgatcctttg tatatacttt ggatatatat     5100

taaaggcaaa actatctctt gactaactga tggattcatt tactaaagca cagctgtatg     5160

tatttttgaa tacatattat gatcttgaga ctttataaat caatttttat gactttatgc     5220

agttgtatag ggattatgcc ctttcagttc tatagggatt atgccctttt ataatacata     5280

atataccaca gagattacaa atgttgagga atgaaagcac ttctttgctt tggcaatcat     5340

tttcagacca ctatgtgttt gaatcctctg gtatcaatac gtattatagg gttttagaga     5400

tctgtgggtc aaatgatgtc cctcaaaact tcctaaaaag gtgaagctca aagtcacaca     5460

ttcttataag gcgcatgagt ttctcatttt cccatgtacg agcattgtaa aggaattcag     5520

ctgtattaat ttctatttca gatctagaat tgacattttg ccttcttgtt tccaggtgtt     5580

tctatttttt gtattctttc agagaaatct catatttcgg tgtatttatt gctgttacta     5640

ctatatttac tgctgaaaac tgtaacaacc tgaagatttg taaaatgtta aacatagttc     5700

attaaaaata ataaaataaa tctaaaatgt a                                    5731


<210>  58
<211>  826
<212>  PRT
<213>  Homo sapiens

<400>  58

Met Ala Arg Leu Cys Arg Arg Val Pro Cys Thr Leu Leu Leu Gly Leu 
1               5                   10                  15      


Ala Val Val Leu Leu Lys Ala Arg Leu Val Pro Ala Ala Ala Arg Ala 
            20                  25                  30          


Glu Leu Ser Arg Ser Asp Leu Ser Leu Ile Gln Gln Gln Gln Gln Gln 
        35                  40                  45              


Gln Gln Gln Gln Gln Gln Gln Gln Lys Gln Leu Glu Glu Ala Glu Glu 
    50                  55                  60                  


Glu Arg Thr Glu Val Pro Gly Ala Thr Ser Thr Leu Thr Val Pro Val 
65                  70                  75                  80  


Ser Val Phe Met Leu Lys Val Gln Val Asn Asp Ile Ile Ser Arg Gln 
                85                  90                  95      


Tyr Leu Ser Gln Ala Val Val Glu Val Phe Val Asn Tyr Thr Lys Thr 
            100                 105                 110         


Asn Ser Thr Val Thr Lys Ser Asn Gly Ala Val Leu Ile Lys Val Pro 
        115                 120                 125             


Tyr Lys Leu Gly Leu Ser Leu Thr Ile Ile Ala Tyr Lys Asp Gly Tyr 
    130                 135                 140                 


Val Leu Thr Pro Leu Pro Trp Lys Thr Arg Arg Met Pro Ile Tyr Ser 
145                 150                 155                 160 


Ser Val Thr Leu Ser Leu Phe Pro Gln Ser Gln Ala Asn Ile Trp Leu 
                165                 170                 175     


Phe Glu Asp Thr Val Leu Ile Thr Gly Lys Leu Ala Asp Ala Lys Ser 
            180                 185                 190         


Gln Pro Ser Val Gln Phe Ser Lys Ala Leu Ile Lys Leu Pro Asp Asn 
        195                 200                 205             


His His Ile Ser Asn Val Thr Gly Tyr Leu Thr Val Leu Gln Gln Phe 
    210                 215                 220                 


Leu Lys Val Asp Asn Phe Leu His Thr Thr Gly Ile Thr Leu Asn Lys 
225                 230                 235                 240 


Pro Gly Phe Glu Asn Ile Glu Leu Thr Pro Leu Ala Ala Ile Cys Val 
                245                 250                 255     


Lys Ile Tyr Ser Gly Gly Lys Glu Leu Lys Val Asn Gly Ser Ile Gln 
            260                 265                 270         


Val Ser Leu Pro Leu Leu Arg Leu Asn Asp Ile Ser Ala Gly Asp Arg 
        275                 280                 285             


Ile Pro Ala Trp Thr Phe Asp Met Asn Thr Gly Ala Trp Val Asn His 
    290                 295                 300                 


Gly Arg Gly Met Val Lys Glu His Asn Asn His Leu Ile Trp Thr Tyr 
305                 310                 315                 320 


Asp Ala Pro His Leu Gly Tyr Trp Ile Ala Ala Pro Leu Pro Gly Thr 
                325                 330                 335     


Arg Gly Ser Gly Ile Asn Glu Asp Ser Lys Asp Ile Thr Ala Tyr His 
            340                 345                 350         


Thr Val Phe Leu Thr Ala Ile Leu Gly Gly Thr Ile Val Ile Val Ile 
        355                 360                 365             


Gly Phe Phe Ala Val Leu Leu Cys Tyr Cys Arg Asp Lys Cys Gly Thr 
    370                 375                 380                 


Pro Gln Lys Arg Glu Arg Asn Ile Thr Lys Leu Glu Val Leu Lys Arg 
385                 390                 395                 400 


Asp Gln Thr Thr Ser Thr Thr His Ile Asn His Ile Ser Thr Val Lys 
                405                 410                 415     


Val Ala Leu Lys Ala Glu Asp Lys Ser Gln Leu Phe Asn Ala Lys Asn 
            420                 425                 430         


Ser Ser Tyr Ser Pro Gln Lys Lys Glu Pro Ser Lys Ala Glu Thr Glu 
        435                 440                 445             


Glu Arg Val Ser Met Val Lys Thr Arg Asp Asp Phe Lys Ile Tyr Asn 
    450                 455                 460                 


Glu Asp Val Ser Phe Leu Ser Val Asn Gln Asn Asn Tyr Ser Arg Asn 
465                 470                 475                 480 


Pro Thr Gln Ser Leu Glu Pro Asn Val Gly Ser Lys Gln Pro Lys His 
                485                 490                 495     


Ile Asn Asn Asn Leu Ser Ser Ser Leu Gly Asp Ala Gln Asp Glu Lys 
            500                 505                 510         


Arg Tyr Leu Thr Gly Asn Glu Glu Ala Tyr Gly Arg Ser His Ile Pro 
        515                 520                 525             


Glu Gln Leu Met His Ile Tyr Ser Gln Pro Ile Ala Ile Leu Gln Thr 
    530                 535                 540                 


Ser Asp Leu Phe Ser Thr Pro Glu Gln Leu His Thr Ala Lys Ser Ala 
545                 550                 555                 560 


Thr Leu Pro Arg Lys Gly Gln Leu Val Tyr Gly Gln Leu Met Glu Pro 
                565                 570                 575     


Val Asn Arg Glu Asn Phe Thr Gln Thr Leu Pro Lys Met Pro Ile His 
            580                 585                 590         


Ser His Ala Gln Pro Pro Asp Ala Arg Glu Glu Asp Ile Ile Leu Glu 
        595                 600                 605             


Gly Gln Gln Ser Leu Pro Ser Gln Ala Ser Asp Trp Ser Arg Tyr Ser 
    610                 615                 620                 


Ser Ser Leu Leu Glu Ser Val Ser Val Pro Gly Thr Leu Asn Glu Ala 
625                 630                 635                 640 


Val Val Met Thr Pro Phe Ser Ser Glu Leu Gln Gly Ile Ser Glu Gln 
                645                 650                 655     


Thr Leu Leu Glu Leu Ser Lys Gly Lys Pro Ser Pro His Pro Arg Ala 
            660                 665                 670         


Trp Phe Val Ser Leu Asp Gly Lys Pro Val Ala Gln Val Arg His Ser 
        675                 680                 685             


Phe Ile Asp Leu Lys Lys Gly Lys Arg Thr Gln Ser Asn Asp Thr Ser 
    690                 695                 700                 


Leu Asp Ser Gly Val Asp Met Asn Glu Leu His Ser Ser Arg Lys Leu 
705                 710                 715                 720 


Glu Arg Glu Lys Thr Phe Ile Lys Ser Met His Gln Pro Lys Ile Leu 
                725                 730                 735     


Tyr Leu Glu Asp Leu Asp Leu Ser Ser Ser Glu Ser Gly Thr Thr Val 
            740                 745                 750         


Cys Ser Pro Glu Asp Pro Ala Leu Arg His Ile Leu Asp Gly Gly Ser 
        755                 760                 765             


Gly Val Ile Met Glu His Pro Gly Glu Glu Ser Pro Gly Arg Lys Ser 
    770                 775                 780                 


Thr Val Glu Asp Phe Glu Ala Asn Thr Ser Pro Thr Lys Arg Arg Gly 
785                 790                 795                 800 


Arg Pro Pro Leu Ala Lys Arg Asp Ser Lys Thr Asn Ile Trp Lys Lys 
                805                 810                 815     


Arg Glu Glu Arg Pro Leu Ile Pro Ile Asn 
            820                 825     


<210>  59
<211>  7368
<212>  DNA
<213>  Homo sapiens

<400>  59
gctgtacttt tctgggtgtg tgttagggag gctatgttcc tgaccctccc cctctggggt       60

gagaaggggt ccccgccatg tcctcggggt tggtaggagg agaggattgg agctgttttc      120

tccttgatgc caagatacgc caagctagga gcattctgcc ctttccacag tcatccaccg      180

agaacaggcc tgcaggacgg gacaaggatc agagccttcc tgcaaccccg gccactgcct      240

gctgtctgtg ggcctggact gtgcgggcaa ctgtgcttgg cccgagtgac aaggaggtgg      300

gagagggtag cagcatgggc tacgcggttg gctgccctca gtccccctgc tgctgaagct      360

gccctgccca tgcccaccca ggccgtgggg ccaggggcct gccagggcta ggagtgggcc      420

tgccgttcat gggtctctag ggatttccga gatgcctggg aagagaggct tgggctggtg      480

gtgggcccgg ctgccccttt gcctgctcct cagcctttac ggcccctgga tgccttcctc      540

cctgggaaag cccaaaggcc accctcacat gaattccatc cgcatagatg gggacatcac      600

actgggaggc ctgttcccgg tgcatggccg gggctcagag ggcaagccct gtggagaact      660

taagaaggaa aagggcatcc accggctgga ggccatgctg ttcgccctgg atcgcatcaa      720

caacgacccg gacctgctgc ctaacatcac gctgggcgcc cgcattctgg acacctgctc      780

cagggacacc catgccctcg agcagtcgct gacctttgtg caggcgctca tcgagaagga      840

tggcacagag gtccgctgtg gcagtggcgg cccacccatc atcaccaagc ctgaacgtgt      900

ggtgggtgtc atcggtgctt cagggagctc ggtctccatc atggtggcca acatccttcg      960

cctcttcaag ataccccaga tcagctacgc ctccacagcg ccagacctga gtgacaacag     1020

ccgctacgac ttcttctccc gcgtggtgcc ctcggacacg taccaggccc aggccatggt     1080

ggacatcgtc cgtgccctca agtggaacta tgtgtccaca gtggcctcgg agggcagcta     1140

tggtgagagc ggtgtggagg ccttcatcca gaagtcccgt gaggacgggg gcgtgtgcat     1200

cgcccagtcg gtgaagatac cacgggagcc caaggcaggc gagttcgaca agatcatccg     1260

ccgcctcctg gagacttcga acgccagggc agtcatcatc tttgccaacg aggatgacat     1320

caggcgtgtg ctggaggcag cacgaagggc caaccagaca ggccatttct tctggatggg     1380

ctctgacagc tggggctcca agattgcacc tgtgctgcac ctggaggagg tggctgaggg     1440

tgctgtcacg atcctcccca agaggatgtc cgtacgaggc ttcgaccgct acttctccag     1500

ccgcacgctg gacaacaacc ggcgcaacat ctggtttgcc gagttctggg aggacaactt     1560

ccactgcaag ctgagccgcc acgccctcaa gaagggcagc cacgtcaaga agtgcaccaa     1620

ccgtgagcga attgggcagg attcagctta tgagcaggag gggaaggtgc agtttgtgat     1680

cgatgccgtg tacgccatgg gccacgcgct gcacgccatg caccgtgacc tgtgtcccgg     1740

ccgcgtgggg ctctgcccgc gcatggaccc tgtagatggc acccagctgc ttaagtacat     1800

ccgaaacgtc aacttctcag gcatcgcagg gaaccctgtg accttcaatg agaatggaga     1860

tgcgcctggg cgctatgaca tctaccaata ccagctgcgc aacgattctg ccgagtacaa     1920

ggtcattggc tcctggactg accacctgca ccttagaata gagcggatgc actggccggg     1980

gagcgggcag cagctgcccc gctccatctg cagcctgccc tgccaaccgg gtgagcggaa     2040

gaagacagtg aagggcatgc cttgctgctg gcactgcgag ccttgcacag ggtaccagta     2100

ccaggtggac cgctacacct gtaagacgtg tccctatgac atgcggccca cagagaaccg     2160

cacgggctgc cggcccatcc ccatcatcaa gcttgagtgg ggctcgccct gggccgtgct     2220

gcccctcttc ctggccgtgg tgggcatcgc tgccacgttg ttcgtggtga tcacctttgt     2280

gcgctacaac gacacgccca tcgtcaaggc ctcgggccgt gaactgagct acgtgctgct     2340

ggcaggcatc ttcctgtgct atgccaccac cttcctcatg atcgctgagc ccgaccttgg     2400

cacctgctcg ctgcgccgaa tcttcctggg actagggatg agcatcagct atgcagccct     2460

gctcaccaag accaaccgca tctaccgcat cttcgagcag ggcaagcgct cggtcagtgc     2520

cccacgcttc atcagccccg cctcacagct ggccatcacc ttcagcctca tctcgctgca     2580

gctgctgggc atctgtgtgt ggtttgtggt ggacccctcc cactcggtgg tggacttcca     2640

ggaccagcgg acactcgacc cccgcttcgc caggggtgtg ctcaagtgtg acatctcgga     2700

cctgtcgctc atctgcctgc tgggctacag catgctgctc atggtcacgt gcaccgtgta     2760

tgccatcaag acacgcggcg tgcccgagac cttcaatgag gccaagccca ttggcttcac     2820

catgtacacc acttgcatcg tctggctggc cttcatcccc atcttctttg gcacctcgca     2880

gtcggccgac aagctgtaca tccagacgac gacgctgacg gtctcggtga gtctgagcgc     2940

ctcggtgtcc ctgggaatgc tctacatgcc caaagtctac atcatcctct tccacccgga     3000

gcagaacgtg cccaagcgca agcgcagcct caaagccgtc gttacggcgg ccaccatgtc     3060

caacaagttc acgcagaagg gcaacttccg gcccaacgga gaggccaagt ctgagctctg     3120

cgagaacctt gaggccccag cgctggccac caaacagact tacgtcactt acaccaacca     3180

tgcaatctag cgagtccatg gagctgagca gcaggaggag gagccgtgac cctgtggaag     3240

gtgcgtcggg ccagggccac acccaagggc ccagctgtct tgcctgcccg tgggcaccca     3300

cggacgtggc ttggtgctga ggatagcaga gcccccagcc atcactgctg gcagcctggg     3360

caaaccgggt gagcaacagg aggacgaggg gccggggcgg tgccaggcta ccacaagaac     3420

ctgcgtcttg gaccattgcc cctcccggcc ccaaaccaca ggggctcagg tcgtgtgggc     3480

cccagtgcta gatctctccc tcccttcgtc tctgtctgtg ctgttggcga cccctctgtc     3540

tgtctccagc cctgtctttc tgttctctta tctctttgtt tcaccttttc cctctctggc     3600

gtccccggct gcttgtactc ttggcctttt ctgtgtctcc tttctggctc ttgcctccgc     3660

ctctctctct catcctcttt gtcctcagct cctcctgctt tcttgggtcc caccagtgtc     3720

acttttctgc cgttttcttt cctgttctcc tctgcttcat tctcgtccag ccattgctcc     3780

cctctccctg ccacccttcc ccagttcacc aaaccttaca tgttgcaaaa gagaaaaaag     3840

gaaaaaaaat caaaacacaa aaaagccaaa acgaaaacaa atctcgagtg tgttgccaag     3900

tgctgcgtcc tcctggtggc ctctgtgtgt gtccctgtgg cccgcagcct gcccgcctgc     3960

cccgcccatc tgccgtgtgt cttgcccgcc tgccccgccc gtctgccgtc tgtcttgccc     4020

gcctgcccgc ctgcccctcc tgccgaccac acggagttca gtgcctgggt gtttggtgat     4080

ggttattgac gacaatgtgt agcgcatgat tgtttttata ccaagaacat ttctaataaa     4140

aataaacaca tggttttgca cccgggctcc acatccactg agggtcctgc catgggacca     4200

caggctcagc ctgcagctgg agggcttaga cctagaggga agcgggaact gggctctgga     4260

gacccagggc ttgggggctg tggagactgc tccctaggct gggatctagt gtggtgtggt     4320

gaggccttgg gcatggaggg gccagattcc caggtaaggg gcagggacat tgcaggaaat     4380

tccaggaatc agcacctagt agtcccctaa ttagggggta tgctctgtcc cctgccctgc     4440

agccctggga gggtaacatt tctgccttgc ctgtcctctg tctcacaccc ctcacacctg     4500

ggactgccct tccacccctg cccccataac ctgtgcctct ctccttccag ccaggaagtc     4560

ctcttcttga gaagttagct tcccgggctg ccagcactca tagccgtccc ctcctgcttg     4620

tgttggctcc aggctcgggt gctaagaaga tgtgtgtctg tcctggagat cagtgtgttg     4680

ttatgtgtcc acgtgggccc acaagtgcac ggcacaggca tggccgtgtg gctgtgttgg     4740

ctgtgttggc tgtgtgtctg tgtgcacgtc cagcgcctcc atgcgcatgc gtgcctgtct     4800

tgtttgcgtg tctgatcatc tgtttgggcc ccggtggctc atgcagatgc ctgtctcagg     4860

cccatggcga gtgttcacct cagctggctt ccctggcagg ttgggaggtg ggaaacagga     4920

gcgcttaggg gctgggctct ggctggggta aattatagag ccagaaacac aatgaggcca     4980

taggcagcag ctggagcctg ggctgcctgt gccgtcccct cctgccctgc ccctgggtcc     5040

tgcaccccct cccacctcca ggctagctga cagcgctatg gagcacagtg gaagggactg     5100

gaggaaccct aggcaggggg ccacgcaggg acagagtatg agagtgtgtg tataactgag     5160

gctgggacat tgaatcatgc caggtatgtc ttctccatca gcccactctt actcctggcc     5220

tgggcatctc acacatctgt gcataggaaa tctcttcttc cctggggtct gtgtgcagca     5280

cctagtagat gctcaataaa tgtttgtgtg agggaaggag acaggaaagg aagtgtctcg     5340

ctgatcatct tgcggaatgg ttcctaagac ctctgcccag gaaagattcc acccagtgct     5400

ccagcccggt caggcagaac taggttgcca gatcaagggt atctcccaaa agcttccagg     5460

gcagttgggg gtgggggggt ggggggtagg gatggggaat gcagaagcgg gtgcagccag     5520

ctctccccca gggtgactct ggcagcaccc ccatcctggg caccctgcct gctctgtggc     5580

tcacgcccct cctgaagtga ctgatgctct gaggcccaag gctaggtcca gggcagggcc     5640

tgcaggggtt tcatgctcag tccaggactt gcctaggtcc ccctacatct gtggggcccc     5700

catctaggtt ctaacaggag aatcacctct ccaaggggga tgctgcccct cggctcccct     5760

tggctctcag gaggggccct cagggactac cagtcccctg ccagtgggaa gaaatagccc     5820

tgccctcagg gagcttccag tgtgatgggg gagatacagc agactgtgtc ccaaagtaaa     5880

atgactgtta gaatgaggtg ggtggaggag ggaagccttg ggtgggtgtg actttgggca     5940

tctgagcctg gggtgcagag gtgggctctg tgggcctgag gtggacagga gggaaccagg     6000

ccctagcaag acttttgcca gctagacctg ctgcagcagt tgggagggtg ggtgctgctg     6060

gagtcctggg tccatcacct agaaggctca ggccagtgca gccagggctg gggcccacag     6120

ctggcctggg tgggacctgc cctgatgccc atggcaggag ggacgcctgg cccttcacaa     6180

ttggcttggc tgctcacctt tgctctcatc ctcaattatt aatgactgga gaaagctgct     6240

aagtatcttc agaatgttag atttcaacaa gatggggggt tcagggtccc tggcaccctg     6300

gatagggagc cagcggcccc tagagacctt tgctgtgtgc agggggtatg tgctcacccc     6360

cgtggcctca gcctcctcaa tgtctgaatg aaggattggg ctagcagaca tcccacccca     6420

cagcacactt tctaaccagc aggggaactt ctagacaata gagacgctgg gctccctcca     6480

gaacactgga cctgaacttc tggggggagg gctgggcacg ggcatatttt aaaagctccc     6540

cagcagatgg gccgtgcagt caagtgggcc aagagtggca ccagactttg gggcttgtga     6600

agtcaggagg gagcaacagt gcccactcga gcttgcctgg ggctcaagcc caaggctggg     6660

ctgctgccag cctgagcaga cacccaggag cttccaggcc agctggatgc acagggcacc     6720

tttgtggaac tcctaggacc ctggggagac ccacctcagg agcagagtct caggtccctt     6780

ccggctctga ggggctgttc tgagctctaa tgtcttatgg tctgcccctc ccatccttac     6840

ttctcaggcc ctggaggcag aggcatagag ccaggcagga cagaggtctc agtgggccac     6900

atgccagctg cccccacact gcctcagcct ccaggcctcc aaggggtcct ggggagcccc     6960

tgagaagatg ctgagcctgc ataaggctgg gcgcccctct ttctgacacc ctcactggct     7020

ccacggctcc cccttcccat cccaggtttc catctgccca ctgaacaggg aggggaaact     7080

gaggcactcc cctggcactg agggctcctt ctgtcatcct gcctgccctg gatggtcctg     7140

gctgcccctc agggcttggc cctggcactg tgagcctcac agggctcaga cccccacccc     7200

caacccagca ctaaatggca ctcggcacca gaatctcact tcagttggca aaagcagcaa     7260

ttagcatgta atgaggcttc ttgctttatt tttaggtaac ctccaaggcc ctgcctgtgt     7320

aattcagccc gccattgctc ggtggataat taaagcatgt caccataa                  7368


<210>  60
<211>  912
<212>  PRT
<213>  Homo sapiens

<400>  60

Met Pro Gly Lys Arg Gly Leu Gly Trp Trp Trp Ala Arg Leu Pro Leu 
1               5                   10                  15      


Cys Leu Leu Leu Ser Leu Tyr Gly Pro Trp Met Pro Ser Ser Leu Gly 
            20                  25                  30          


Lys Pro Lys Gly His Pro His Met Asn Ser Ile Arg Ile Asp Gly Asp 
        35                  40                  45              


Ile Thr Leu Gly Gly Leu Phe Pro Val His Gly Arg Gly Ser Glu Gly 
    50                  55                  60                  


Lys Pro Cys Gly Glu Leu Lys Lys Glu Lys Gly Ile His Arg Leu Glu 
65                  70                  75                  80  


Ala Met Leu Phe Ala Leu Asp Arg Ile Asn Asn Asp Pro Asp Leu Leu 
                85                  90                  95      


Pro Asn Ile Thr Leu Gly Ala Arg Ile Leu Asp Thr Cys Ser Arg Asp 
            100                 105                 110         


Thr His Ala Leu Glu Gln Ser Leu Thr Phe Val Gln Ala Leu Ile Glu 
        115                 120                 125             


Lys Asp Gly Thr Glu Val Arg Cys Gly Ser Gly Gly Pro Pro Ile Ile 
    130                 135                 140                 


Thr Lys Pro Glu Arg Val Val Gly Val Ile Gly Ala Ser Gly Ser Ser 
145                 150                 155                 160 


Val Ser Ile Met Val Ala Asn Ile Leu Arg Leu Phe Lys Ile Pro Gln 
                165                 170                 175     


Ile Ser Tyr Ala Ser Thr Ala Pro Asp Leu Ser Asp Asn Ser Arg Tyr 
            180                 185                 190         


Asp Phe Phe Ser Arg Val Val Pro Ser Asp Thr Tyr Gln Ala Gln Ala 
        195                 200                 205             


Met Val Asp Ile Val Arg Ala Leu Lys Trp Asn Tyr Val Ser Thr Val 
    210                 215                 220                 


Ala Ser Glu Gly Ser Tyr Gly Glu Ser Gly Val Glu Ala Phe Ile Gln 
225                 230                 235                 240 


Lys Ser Arg Glu Asp Gly Gly Val Cys Ile Ala Gln Ser Val Lys Ile 
                245                 250                 255     


Pro Arg Glu Pro Lys Ala Gly Glu Phe Asp Lys Ile Ile Arg Arg Leu 
            260                 265                 270         


Leu Glu Thr Ser Asn Ala Arg Ala Val Ile Ile Phe Ala Asn Glu Asp 
        275                 280                 285             


Asp Ile Arg Arg Val Leu Glu Ala Ala Arg Arg Ala Asn Gln Thr Gly 
    290                 295                 300                 


His Phe Phe Trp Met Gly Ser Asp Ser Trp Gly Ser Lys Ile Ala Pro 
305                 310                 315                 320 


Val Leu His Leu Glu Glu Val Ala Glu Gly Ala Val Thr Ile Leu Pro 
                325                 330                 335     


Lys Arg Met Ser Val Arg Gly Phe Asp Arg Tyr Phe Ser Ser Arg Thr 
            340                 345                 350         


Leu Asp Asn Asn Arg Arg Asn Ile Trp Phe Ala Glu Phe Trp Glu Asp 
        355                 360                 365             


Asn Phe His Cys Lys Leu Ser Arg His Ala Leu Lys Lys Gly Ser His 
    370                 375                 380                 


Val Lys Lys Cys Thr Asn Arg Glu Arg Ile Gly Gln Asp Ser Ala Tyr 
385                 390                 395                 400 


Glu Gln Glu Gly Lys Val Gln Phe Val Ile Asp Ala Val Tyr Ala Met 
                405                 410                 415     


Gly His Ala Leu His Ala Met His Arg Asp Leu Cys Pro Gly Arg Val 
            420                 425                 430         


Gly Leu Cys Pro Arg Met Asp Pro Val Asp Gly Thr Gln Leu Leu Lys 
        435                 440                 445             


Tyr Ile Arg Asn Val Asn Phe Ser Gly Ile Ala Gly Asn Pro Val Thr 
    450                 455                 460                 


Phe Asn Glu Asn Gly Asp Ala Pro Gly Arg Tyr Asp Ile Tyr Gln Tyr 
465                 470                 475                 480 


Gln Leu Arg Asn Asp Ser Ala Glu Tyr Lys Val Ile Gly Ser Trp Thr 
                485                 490                 495     


Asp His Leu His Leu Arg Ile Glu Arg Met His Trp Pro Gly Ser Gly 
            500                 505                 510         


Gln Gln Leu Pro Arg Ser Ile Cys Ser Leu Pro Cys Gln Pro Gly Glu 
        515                 520                 525             


Arg Lys Lys Thr Val Lys Gly Met Pro Cys Cys Trp His Cys Glu Pro 
    530                 535                 540                 


Cys Thr Gly Tyr Gln Tyr Gln Val Asp Arg Tyr Thr Cys Lys Thr Cys 
545                 550                 555                 560 


Pro Tyr Asp Met Arg Pro Thr Glu Asn Arg Thr Gly Cys Arg Pro Ile 
                565                 570                 575     


Pro Ile Ile Lys Leu Glu Trp Gly Ser Pro Trp Ala Val Leu Pro Leu 
            580                 585                 590         


Phe Leu Ala Val Val Gly Ile Ala Ala Thr Leu Phe Val Val Ile Thr 
        595                 600                 605             


Phe Val Arg Tyr Asn Asp Thr Pro Ile Val Lys Ala Ser Gly Arg Glu 
    610                 615                 620                 


Leu Ser Tyr Val Leu Leu Ala Gly Ile Phe Leu Cys Tyr Ala Thr Thr 
625                 630                 635                 640 


Phe Leu Met Ile Ala Glu Pro Asp Leu Gly Thr Cys Ser Leu Arg Arg 
                645                 650                 655     


Ile Phe Leu Gly Leu Gly Met Ser Ile Ser Tyr Ala Ala Leu Leu Thr 
            660                 665                 670         


Lys Thr Asn Arg Ile Tyr Arg Ile Phe Glu Gln Gly Lys Arg Ser Val 
        675                 680                 685             


Ser Ala Pro Arg Phe Ile Ser Pro Ala Ser Gln Leu Ala Ile Thr Phe 
    690                 695                 700                 


Ser Leu Ile Ser Leu Gln Leu Leu Gly Ile Cys Val Trp Phe Val Val 
705                 710                 715                 720 


Asp Pro Ser His Ser Val Val Asp Phe Gln Asp Gln Arg Thr Leu Asp 
                725                 730                 735     


Pro Arg Phe Ala Arg Gly Val Leu Lys Cys Asp Ile Ser Asp Leu Ser 
            740                 745                 750         


Leu Ile Cys Leu Leu Gly Tyr Ser Met Leu Leu Met Val Thr Cys Thr 
        755                 760                 765             


Val Tyr Ala Ile Lys Thr Arg Gly Val Pro Glu Thr Phe Asn Glu Ala 
    770                 775                 780                 


Lys Pro Ile Gly Phe Thr Met Tyr Thr Thr Cys Ile Val Trp Leu Ala 
785                 790                 795                 800 


Phe Ile Pro Ile Phe Phe Gly Thr Ser Gln Ser Ala Asp Lys Leu Tyr 
                805                 810                 815     


Ile Gln Thr Thr Thr Leu Thr Val Ser Val Ser Leu Ser Ala Ser Val 
            820                 825                 830         


Ser Leu Gly Met Leu Tyr Met Pro Lys Val Tyr Ile Ile Leu Phe His 
        835                 840                 845             


Pro Glu Gln Asn Val Pro Lys Arg Lys Arg Ser Leu Lys Ala Val Val 
    850                 855                 860                 


Thr Ala Ala Thr Met Ser Asn Lys Phe Thr Gln Lys Gly Asn Phe Arg 
865                 870                 875                 880 


Pro Asn Gly Glu Ala Lys Ser Glu Leu Cys Glu Asn Leu Glu Ala Pro 
                885                 890                 895     


Ala Leu Ala Thr Lys Gln Thr Tyr Val Thr Tyr Thr Asn His Ala Ile 
            900                 905                 910         


<210>  61
<211>  4959
<212>  DNA
<213>  Homo sapiens

<400>  61
acttgtatct tttcatatca aaaatgggag gtgacaccca gtttaaggaa aattccaagg       60

catttgtctc gactaatgtg aaagatgatt acagtggcca gaggactgcc aaggctcctt      120

ctcaagctgc ttgagtcaat gagggtagac gcaccctctg aagatggtga ctccctcctg      180

agaagctgga ccccttggta aaagacaagg ccttctccaa gaagaatatg aaagtgttac      240

tcagacttat ttgtttcata gctctactga tttcttctct ggaggctgat aaatgcaagg      300

aacgtgaaga aaaaataatt ttagtgtcat ctgcaaatga aattgatgtt cgtccctgtc      360

ctcttaaccc aaatgaacac aaaggcacta taacttggta taaagatgac agcaagacac      420

ctgtatctac agaacaagcc tccaggattc atcaacacaa agagaaactt tggtttgttc      480

ctgctaaggt ggaggattca ggacattact attgcgtggt aagaaattca tcttactgcc      540

tcagaattaa aataagtgca aaatttgtgg agaatgagcc taacttatgt tataatgcac      600

aagccatatt taagcagaaa ctacccgttg caggagacgg aggacttgtg tgcccttata      660

tggagttttt taaaaatgaa aataatgagt tacctaaatt acagtggtat aaggattgca      720

aacctctact tcttgacaat atacacttta gtggagtcaa agataggctc atcgtgatga      780

atgtggctga aaagcataga gggaactata cttgtcatgc atcctacaca tacttgggca      840

agcaatatcc tattacccgg gtaatagaat ttattactct agaggaaaac aaacccacaa      900

ggcctgtgat tgtgagccca gctaatgaga caatggaagt agacttggga tcccagatac      960

aattgatctg taatgtcacc ggccagttga gtgacattgc ttactggaag tggaatgggt     1020

cagtaattga tgaagatgac ccagtgctag gggaagacta ttacagtgtg gaaaatcctg     1080

caaacaaaag aaggagtacc ctcatcacag tgcttaatat atcggaaatt gaaagtagat     1140

tttataaaca tccatttacc tgttttgcca agaatacaca tggtatagat gcagcatata     1200

tccagttaat atatccagtc actaatttcc agaagcacat gattggtata tgtgtcacgt     1260

tgacagtcat aattgtgtgt tctgttttca tctataaaat cttcaagatt gacattgtgc     1320

tttggtacag ggattcctgc tatgattttc tcccaataaa agtcttgcct gaggtcttgg     1380

aaaaacagtg tggatataag ctgttcattt atggaaggga tgactacgtt ggggaagaca     1440

ttgttgaggt cattaatgaa aacgtaaaga aaagcagaag actgattatc attttagtca     1500

gagaaacatc aggcttcagc tggctgggtg gttcatctga agagcaaata gccatgtata     1560

atgctcttgt tcaggatgga attaaagttg tcctgcttga gctggagaaa atccaagact     1620

atgagaaaat gccagaatcg attaaattca ttaagcagaa acatggggct atccgctggt     1680

caggggactt tacacaggga ccacagtctg caaagacaag gttctggaag aatgtcaggt     1740

accacatgcc agtccagcga cggtcacctt catctaaaca ccagttactg tcaccagcca     1800

ctaaggagaa actgcaaaga gaggctcacg tgcctctcgg gtagcatgga gaagttgcca     1860

agagttcttt aggtgcctcc tgtcttatgg cgttgcaggc caggttatgc ctcatgctga     1920

cttgcagagt tcatggaatg taactatatc atcctttatc cctgaggtca cctggaatca     1980

gattattaag ggaataagcc atgacgtcaa tagcagccca gggcacttca gagtagaggg     2040

cttgggaaga tcttttaaaa aggcagtagg cccggtgtgg tggctcacgc ctataatccc     2100

agcactttgg gaggctgaag tgggtggatc accagaggtc aggagttcga gaccagccca     2160

gccaacatgg caaaacccca tctctactaa aaatacaaaa atgagctagg catggtggca     2220

cacgcctgta atcccagcta cacctgaggc tgaggcagga gaattgcttg aaccggggag     2280

acggaggttg cagtgagccg agtttgggcc actgcactct agcctggcaa cagagcaaga     2340

ctccgtctca aaaaaagggc aataaatgcc ctctctgaat gtttgaactg ccaagaaaag     2400

gcatggagac agcgaactag aagaaagggc aagaaggaaa tagccaccgt ctacagatgg     2460

cttagttaag tcatccacag cccaagggcg gggctatgcc ttgtctgggg accctgtaga     2520

gtcactgacc ctggagcggc tctcctgaga ggtgctgcag gcaaagtgag actgacacct     2580

cactgaggaa gggagacata ttcttggaga actttccatc tgcttgtatt ttccatacac     2640

atccccagcc agaagttagt gtccgaagac cgaattttat tttacagagc ttgaaaactc     2700

acttcaatga acaaagggat tctccaggat tccaaagttt tgaagtcatc ttagctttcc     2760

acaggaggga gagaacttaa aaaagcaaca gtagcaggga attgatccac ttcttaatgc     2820

tttcctccct ggcatgacca tcctgtcctt tgttattatc ctgcatttta cgtctttgga     2880

ggaacagctc cctagtggct tcctccgtct gcaatgtccc ttgcacagcc cacacatgaa     2940

ccatccttcc catgatgccg ctcttctgtc atcccgctcc tgctgaaaca cctcccaggg     3000

gctccacctg ttcaggagct gaagcccatg ctttcccacc agcatgtcac tcccagacca     3060

cctccctgcc ctgtcctcca gcttcccctc gctgtcctgc tgtgtgaatt cccaggttgg     3120

cctggtggcc atgtcgcctg cccccagcac tcctctgtct ctgctcttgc ctgcaccctt     3180

cctcctcctt tgcctaggag gccttctcgc attttctcta gctgatcaga attttaccaa     3240

aattcagaac atcctccaat tccacagtct ctgggagact ttccctaaga ggcgacttcc     3300

tctccagcct tctctctctg gtcaggccca ctgcagagat ggtggtgagc acatctggga     3360

ggctggtctc cctccagctg gaattgctgc tctctgaggg agaggctgtg gtggctgtct     3420

ctgtccctca ctgccttcca ggagcaattt gcacatgtaa catagattta tgtaatgctt     3480

tatgtttaaa aacattcccc aattatctta tttaattttt gcaattattc taattttata     3540

tatagagaaa gtgacctatt ttttaaaaaa atcacactct aagttctatt gaacctagga     3600

cttgagcctc catttctggc ttctagtctg gtgttctgag tacttgattt caggtcaata     3660

acggtccccc ctcactccac actggcacgt ttgtgagaag aaatgacatt ttgctaggaa     3720

gtgaccgagt ctaggaatgc ttttattcaa gacaccaaat tccaaacttc taaatgttgg     3780

aattttcaaa aattgtgttt agattttatg aaaaactctt ctactttcat ctattctttc     3840

cctagaggca aacatttctt aaaatgtttc attttcatta aaaatgaaag ccaaatttat     3900

atgccaccga ttgcaggaca caagcacagt tttaagagtt gtatgaacat ggagaggact     3960

tttggttttt atatttctcg tatttaatat gggtgaacac caacttttat ttggaataat     4020

aattttcctc ctaaacaaaa acacattgag tttaagtctc tgactcttgc ctttccacct     4080

gctttctcct gggcccgctt tgcctgcttg aaggaacagt gctgttctgg agctgctgtt     4140

ccaacagaca gggcctagct ttcatttgac acacagacta cagccagaag cccatggagc     4200

agggatgtca cgtcttgaaa agcctattag atgttttaca aatttaattt tgcagattat     4260

tttagtctgt catccagaaa atgtgtcagc atgcatagtg ctaagaaagc aagccaattt     4320

ggaaacttag gttagtgaca aaattggcca gagagtgggg gtgatgatga ccaagaatta     4380

caagtagaat ggcagctgga atttaaggag ggacaagaat caatggataa gcgtgggtgg     4440

aggaagatcc aaacagaaaa gtgcaaagtt attccccatc ttccaagggt tgaattctgg     4500

aggaagaaga cacattccta gttccccgtg aacttccttt gacttattgt ccccactaaa     4560

acaaaacaaa aaacttttaa tgccttccac attaattaga ttttcttgca gtttttttat     4620

ggcatttttt taaagatgcc ctaagtgttg aagaagagtt tgcaaatgca acaaaatatt     4680

taattaccgg ttgttaaaac tggtttagca caatttatat tttccctctc ttgcctttct     4740

tatttgcaat aaaaggtatt gagccatttt ttaaatgaca tttttgataa attatgtttg     4800

tactagttga tgaaggagtt ttttttaacc tgtttatata attttgcagc agaagccaaa     4860

ttttttgtat attaaagcac caaattcatg tacagcatgc atcacggatc aatagactgt     4920

acttattttc caataaaatt ttcaaacttt gtactgtta                            4959


<210>  62
<211>  569
<212>  PRT
<213>  Homo sapiens

<400>  62

Met Lys Val Leu Leu Arg Leu Ile Cys Phe Ile Ala Leu Leu Ile Ser 
1               5                   10                  15      


Ser Leu Glu Ala Asp Lys Cys Lys Glu Arg Glu Glu Lys Ile Ile Leu 
            20                  25                  30          


Val Ser Ser Ala Asn Glu Ile Asp Val Arg Pro Cys Pro Leu Asn Pro 
        35                  40                  45              


Asn Glu His Lys Gly Thr Ile Thr Trp Tyr Lys Asp Asp Ser Lys Thr 
    50                  55                  60                  


Pro Val Ser Thr Glu Gln Ala Ser Arg Ile His Gln His Lys Glu Lys 
65                  70                  75                  80  


Leu Trp Phe Val Pro Ala Lys Val Glu Asp Ser Gly His Tyr Tyr Cys 
                85                  90                  95      


Val Val Arg Asn Ser Ser Tyr Cys Leu Arg Ile Lys Ile Ser Ala Lys 
            100                 105                 110         


Phe Val Glu Asn Glu Pro Asn Leu Cys Tyr Asn Ala Gln Ala Ile Phe 
        115                 120                 125             


Lys Gln Lys Leu Pro Val Ala Gly Asp Gly Gly Leu Val Cys Pro Tyr 
    130                 135                 140                 


Met Glu Phe Phe Lys Asn Glu Asn Asn Glu Leu Pro Lys Leu Gln Trp 
145                 150                 155                 160 


Tyr Lys Asp Cys Lys Pro Leu Leu Leu Asp Asn Ile His Phe Ser Gly 
                165                 170                 175     


Val Lys Asp Arg Leu Ile Val Met Asn Val Ala Glu Lys His Arg Gly 
            180                 185                 190         


Asn Tyr Thr Cys His Ala Ser Tyr Thr Tyr Leu Gly Lys Gln Tyr Pro 
        195                 200                 205             


Ile Thr Arg Val Ile Glu Phe Ile Thr Leu Glu Glu Asn Lys Pro Thr 
    210                 215                 220                 


Arg Pro Val Ile Val Ser Pro Ala Asn Glu Thr Met Glu Val Asp Leu 
225                 230                 235                 240 


Gly Ser Gln Ile Gln Leu Ile Cys Asn Val Thr Gly Gln Leu Ser Asp 
                245                 250                 255     


Ile Ala Tyr Trp Lys Trp Asn Gly Ser Val Ile Asp Glu Asp Asp Pro 
            260                 265                 270         


Val Leu Gly Glu Asp Tyr Tyr Ser Val Glu Asn Pro Ala Asn Lys Arg 
        275                 280                 285             


Arg Ser Thr Leu Ile Thr Val Leu Asn Ile Ser Glu Ile Glu Ser Arg 
    290                 295                 300                 


Phe Tyr Lys His Pro Phe Thr Cys Phe Ala Lys Asn Thr His Gly Ile 
305                 310                 315                 320 


Asp Ala Ala Tyr Ile Gln Leu Ile Tyr Pro Val Thr Asn Phe Gln Lys 
                325                 330                 335     


His Met Ile Gly Ile Cys Val Thr Leu Thr Val Ile Ile Val Cys Ser 
            340                 345                 350         


Val Phe Ile Tyr Lys Ile Phe Lys Ile Asp Ile Val Leu Trp Tyr Arg 
        355                 360                 365             


Asp Ser Cys Tyr Asp Phe Leu Pro Ile Lys Ala Ser Asp Gly Lys Thr 
    370                 375                 380                 


Tyr Asp Ala Tyr Ile Leu Tyr Pro Lys Thr Val Gly Glu Gly Ser Thr 
385                 390                 395                 400 


Ser Asp Cys Asp Ile Phe Val Phe Lys Val Leu Pro Glu Val Leu Glu 
                405                 410                 415     


Lys Gln Cys Gly Tyr Lys Leu Phe Ile Tyr Gly Arg Asp Asp Tyr Val 
            420                 425                 430         


Gly Glu Asp Ile Val Glu Val Ile Asn Glu Asn Val Lys Lys Ser Arg 
        435                 440                 445             


Arg Leu Ile Ile Ile Leu Val Arg Glu Thr Ser Gly Phe Ser Trp Leu 
    450                 455                 460                 


Gly Gly Ser Ser Glu Glu Gln Ile Ala Met Tyr Asn Ala Leu Val Gln 
465                 470                 475                 480 


Asp Gly Ile Lys Val Val Leu Leu Glu Leu Glu Lys Ile Gln Asp Tyr 
                485                 490                 495     


Glu Lys Met Pro Glu Ser Ile Lys Phe Ile Lys Gln Lys His Gly Ala 
            500                 505                 510         


Ile Arg Trp Ser Gly Asp Phe Thr Gln Gly Pro Gln Ser Ala Lys Thr 
        515                 520                 525             


Arg Phe Trp Lys Asn Val Arg Tyr His Met Pro Val Gln Arg Arg Ser 
    530                 535                 540                 


Pro Ser Ser Lys His Gln Leu Leu Ser Pro Ala Thr Lys Glu Lys Leu 
545                 550                 555                 560 


Gln Arg Glu Ala His Val Pro Leu Gly 
                565                 


<210>  63
<211>  3142
<212>  DNA
<213>  Homo sapiens

<400>  63
aacttcctgt tgtcaccaca cctctgagtc gtctgagctc actgtgagca aaatcccaca       60

gtggaaactc ttaagcctct gcgaagtaaa tcattcttgt gaatgtgaca cacgatctct      120

ccagtttcca tatgttgaga ttctacttat tcatcagttt gttgtgcttg tcaagatcag      180

acgcagaaga aacatgtcct tcattcacca ggctgagctt tcacagtgca gtggttggta      240

cgggactaaa tgtgaggctg atgctctaca caaggaaaaa cctgacctgc gcacaaacca      300

tcaactcctc agcttttggg aacttgaatg tgaccaagaa aaccaccttc attgtccatg      360

gattcaggcc aacaggctcc cctcctgttt ggatggatga cttagtaaag ggtttgctct      420

ctgttgaaga catgaacgta gttgttgttg attggaatcg aggagctaca actttaatat      480

atacccatgc ctctagtaag accagaaaag tagccatggt cttgaaggaa tttattgacc      540

agatgttggc agaaggagct tctcttgatg acatttacat gatcggagta agtctaggag      600

cccacatatc tgggtttgtt ggagagatgt acgatggatg gctggggaga attacaggcc      660

tcgaccctgc aggcccttta ttcaacggga aacctcacca agacagatta gatcccagtg      720

atgcgcagtt tgttgatgtc atccattccg acactgatgg atttcagtat tttaaatgtg      780

accaccagag gtctgtatac ctgtacctgt cttccctgag agagagctgc accatcactg      840

cgtatccctg tgactcctac caggattata ggaatggcaa gtgtgtcagc tgcggcacgt      900

cacaaaaaga gtcctgtccc cttctgggct attatgctga taattggaaa gaccatctaa      960

gggggaaaga tcctccaatg acgaaggcat tctttgacac agctgaggag agcccattct     1020

gcatgtatca ttactttgtg gatattataa catggaacaa gaatgtaaga agaggggaca     1080

ttaccatcaa attgagagac aaagctggaa acaccacaga atccaaaatc aatcatgaac     1140

ccaccacatt tcagaaatat caccaagtga gtctacttgc aagatttaat caagatctgg     1200

ataaagtggc tgcaatttcc ttgatgttct ctacaggatc tctaataggc ccaaggtaca     1260

agctcaggat tctccgaatg aagttaaggt cccttgccca tccggagagg cctcagctgt     1320

gtcggtatga tcttgtcctg atggaaaacg ttgaaacagt cttccaacct attctttgcc     1380

cagagttgca gttgtaactg ttgccaggac acatggccat aaataataga aagaaagcta     1440

caaccacagg ctgtttgaaa gcttcacctc acctttctgc aaggcagaaa aagtatgaaa     1500

aaaaccaagg cttttttcag tagcgtccta tggatgtcac attgtacatc aaacaacctt     1560

gtgattataa aacgatcctg ggaaggagcc cctaactagg gcaagtcaga aatagccagg     1620

ctcgcagcag cgcagcgctg tgtctgctgt gtcctggggc ctcccttgtt ccgacctgtc     1680

aattctgctg cctgtcacgc gggtggttct gcccatcgcg gctgcgggtc aagcatcttc     1740

aagggaagga cggactggag gcctcaccgt ggactcaact ctgcattctc cgtgccacat     1800

tcctccagtt cccacacgta gaagggaacg aaactgacgt ctacctcatg gggctgctgt     1860

gtgggtttgg gaggcaaaaa tctatgaagg gttttttgaa atcccatagg tgccacatct     1920

atgagatgtt tgataaatgt gaatatgctt ttacatttgg gcttatctaa tttgcaataa     1980

gagagcctct ctctatcaac accagcttct ctctcgggct gtttgctcag ggaaggcaag     2040

aaagccacgt gctggccctc tgccttctct aaagtgctgt tggagcatgg aggagctgga     2100

ggagatgggg atggactgac agctaagagg gcggctgctg ggactagata gtggatgaag     2160

aaagaaggac gaggaagccg tggggcagcc tcttcacatg gggacagggg atggagcatg     2220

aggcaaggga aggaaaagca gagcttattt ttcacctaag gtggagaagg atcactttac     2280

aggcaacgct cattttaagc aacccttaag aaatgtttat gtttctttat taccaatgta     2340

atctatgatt attgaaggaa atttagaaaa tgcgtagata caaaattaaa aaaaaatact     2400

gtccacgatc ctattagagg taattaatgt tagccttttg gaacaaggct gtcacctatt     2460

ttgccaacac gtgaattcaa aacatgaacc ggtttgcttt tggagaatct gaagactcca     2520

gtttgaggaa tcctttgctt ccctggaggt agatgctgtc tgcaaatcta gaatgacagc     2580

aggagtccag tcaagaggtc ctgtcaggcc aaggccagaa agaagggagg acaatccctg     2640

gggccagatg cccagtgtga ggggaggcat gatctgtccc atggctgtgg ccactgcagg     2700

aaggtctgtg aaaaggaggt gacaggccca gtcacctcct cttcacccaa gtgattgctc     2760

cttcaactgc tatctgtgaa aatagccttt gttatgaaga aattgactct ctctctcttt     2820

tttttttttt ggagttgcct aggctggagt gcaatggtac gatctcagct cactgcaacc     2880

tccacctccc aggttcaatt gattctcctg cctcagcctc ctgagtagct gggattacag     2940

gcatgtgcca ccacacccgg ctaatttttg tatttttatt agagacaggg tttcaccacg     3000

ttagccaggc tcgtctcgaa ctcctgtcct caggtgacta cccgtctcgg cctcccaaag     3060

tgctgggatt acaggcatga gccaccacac ccggccaaaa atggattctc tatgtcataa     3120

attaaagaaa tctataaatg ta                                              3142


<210>  64
<211>  451
<212>  PRT
<213>  Homo sapiens

<400>  64

Met Leu Arg Phe Tyr Leu Phe Ile Ser Leu Leu Cys Leu Ser Arg Ser 
1               5                   10                  15      


Asp Ala Glu Glu Thr Cys Pro Ser Phe Thr Arg Leu Ser Phe His Ser 
            20                  25                  30          


Ala Val Val Gly Thr Gly Leu Asn Val Arg Leu Met Leu Tyr Thr Arg 
        35                  40                  45              


Lys Asn Leu Thr Cys Ala Gln Thr Ile Asn Ser Ser Ala Phe Gly Asn 
    50                  55                  60                  


Leu Asn Val Thr Lys Lys Thr Thr Phe Ile Val His Gly Phe Arg Pro 
65                  70                  75                  80  


Thr Gly Ser Pro Pro Val Trp Met Asp Asp Leu Val Lys Gly Leu Leu 
                85                  90                  95      


Ser Val Glu Asp Met Asn Val Val Val Val Asp Trp Asn Arg Gly Ala 
            100                 105                 110         


Thr Thr Leu Ile Tyr Thr His Ala Ser Ser Lys Thr Arg Lys Val Ala 
        115                 120                 125             


Met Val Leu Lys Glu Phe Ile Asp Gln Met Leu Ala Glu Gly Ala Ser 
    130                 135                 140                 


Leu Asp Asp Ile Tyr Met Ile Gly Val Ser Leu Gly Ala His Ile Ser 
145                 150                 155                 160 


Gly Phe Val Gly Glu Met Tyr Asp Gly Trp Leu Gly Arg Ile Thr Gly 
                165                 170                 175     


Leu Asp Pro Ala Gly Pro Leu Phe Asn Gly Lys Pro His Gln Asp Arg 
            180                 185                 190         


Leu Asp Pro Ser Asp Ala Gln Phe Val Asp Val Ile His Ser Asp Thr 
        195                 200                 205             


Asp Ala Leu Gly Tyr Lys Glu Pro Leu Gly Asn Ile Asp Phe Tyr Pro 
    210                 215                 220                 


Asn Gly Gly Leu Asp Gln Pro Gly Cys Pro Lys Thr Ile Leu Gly Gly 
225                 230                 235                 240 


Phe Gln Tyr Phe Lys Cys Asp His Gln Arg Ser Val Tyr Leu Tyr Leu 
                245                 250                 255     


Ser Ser Leu Arg Glu Ser Cys Thr Ile Thr Ala Tyr Pro Cys Asp Ser 
            260                 265                 270         


Tyr Gln Asp Tyr Arg Asn Gly Lys Cys Val Ser Cys Gly Thr Ser Gln 
        275                 280                 285             


Lys Glu Ser Cys Pro Leu Leu Gly Tyr Tyr Ala Asp Asn Trp Lys Asp 
    290                 295                 300                 


His Leu Arg Gly Lys Asp Pro Pro Met Thr Lys Ala Phe Phe Asp Thr 
305                 310                 315                 320 


Ala Glu Glu Ser Pro Phe Cys Met Tyr His Tyr Phe Val Asp Ile Ile 
                325                 330                 335     


Thr Trp Asn Lys Asn Val Arg Arg Gly Asp Ile Thr Ile Lys Leu Arg 
            340                 345                 350         


Asp Lys Ala Gly Asn Thr Thr Glu Ser Lys Ile Asn His Glu Pro Thr 
        355                 360                 365             


Thr Phe Gln Lys Tyr His Gln Val Ser Leu Leu Ala Arg Phe Asn Gln 
    370                 375                 380                 


Asp Leu Asp Lys Val Ala Ala Ile Ser Leu Met Phe Ser Thr Gly Ser 
385                 390                 395                 400 


Leu Ile Gly Pro Arg Tyr Lys Leu Arg Ile Leu Arg Met Lys Leu Arg 
                405                 410                 415     


Ser Leu Ala His Pro Glu Arg Pro Gln Leu Cys Arg Tyr Asp Leu Val 
            420                 425                 430         


Leu Met Glu Asn Val Glu Thr Val Phe Gln Pro Ile Leu Cys Pro Glu 
        435                 440                 445             


Leu Gln Leu 
    450     


<210>  65
<211>  11140
<212>  DNA
<213>  Homo sapiens

<400>  65
aggcaggggg cggcaacatg gcggagtgag cggcggcgtc ggggcttcac aacaacagtg       60

gtggccgtag cagcggcggc agcagcgtca atagcatcgg ccacagcctg agcttcagca      120

ccggccagcg tcgtggccag ctgctcgcgt cctcgggctt ctcggagcgg ctgcagcatc      180

tccgcggggg gcgggccggg ccggacagac cgggagaggg agagagcaga ggcagcggcg      240

gcggcagcgg cagcggcagc ggcacacctg ctgggcgggc acagccgctt gcccggcagc      300

ggttagcggt accgccaccg ccgagaataa gcctgcggat cccccgccgc ctccgcgggg      360

gagagcgccg gagcgggccg ggctgaggcg caggcgggga gcgggcccgg cgccgcggcg      420

ctggtggatg ctggggctcc gaggcgacgg ccggggggcg ggggccgagg caggtataac      480

ggtaccggcg gcggcagcgc cgctgctctt cccttctcct caggaggggg gccaatggct      540

agcgagaagc cgggcccggg cccggggctc gagcctcagc ccgtggggct cattgccgtc      600

ggggccgctg gcggaggcgg cgggggcagc ggtggtggcg gcaccggggg cagcgggatg      660

ggggagctaa ggggggcgtc cggctccggc tcggtgatgc tccccgcggg gatgattaac      720

ccttcggtgc cgatccgcaa catccggatg aaattcgcag tgttgattgg actcatacag      780

gtcggagagg tcagcaacag ggacatcgtg gagacggtgc tcaacctgct ggttggtgga      840

gaatttgact tggagatgaa ctttattatc caggatgctg agagtataac atgtatgaca      900

gagcttttgg agcactgtga tgtaacatgt caagcagaaa tatggagcat gtttacagcc      960

attctacgaa aaagtgttcg gaatttacag actagcacag aagttgggct aattgaacaa     1020

gtattgctga aaatgagtgc tgtagatgac atgatagcag atcttctagt tgatatgttg     1080

ggggttcttg ccagctacag catcactgtc aaggagttga agcttttgtt cagcatgctt     1140

cgaggagaaa gtggaatctg gccaagacat gcagtaaaat tattatcagt tcttaatcag     1200

atgccacaga gacacggtcc tgatactttt ttcaatttcc ctggttgtag cgctgcggca     1260

attgccttgc ctcctattgc aaagtggcct tatcagaatg gcttcacctt aaacacttgg     1320

tttcgtatgg atccattaaa taatattaat gttgataagg ataaacctta tctttattgt     1380

tttcgtacta gcaaaggagt tggttactct gctcattttg ttggcaactg tttaatagtc     1440

acatcattga agtccaaagg aaaaggtttt cagcattgtg tgaaatatga ttttcaacca     1500

cgcaagtggt acatgatcag cattgtccac atttacaatc gatggaggaa cagtgaaatt     1560

cggtgttatg ttaatggaca actggtatct tatggtgata tggcttggca tgttaacaca     1620

aatgatagct atgacaagtg ctttcttgga tcatcagaaa ctgctgatgc aaatagggta     1680

ttctgtggtc aacttggtgc cgtgtatgtg ttcagtgaag cactcaaccc agcacagata     1740

tttgcaattc atcagttagg acctggatat aagagtacct tcaagtttaa atctgagagt     1800

gatattcatt tggcagaaca tcataaacag gtgttatatg atgggaaact tgcaagtagc     1860

attgccttta catataatgc taaggccact gatgctcagc tctgcctgga atcatcacca     1920

aaagagaatg catcaatttt tgtgcattcc ccacatgctc taatgcttca ggatgtgaaa     1980

gcgatagtaa cacattcaat tcatagtgca attcattcaa ttggagggat tcaagtgctt     2040

tttccacttt ttgcccaatt ggataatagg cagctcaatg acagtcaagt ggaaacaact     2100

gtctgtgcta ctctgttggc attcctggtt gaactactta aaagttcagt agccatgcaa     2160

gaacagatgc tgggtggaaa aggcttttta gtcattggct acttacttga aaagtcatca     2220

agagttcata taactagagc tgtcctggag caatttttat cttttgcaaa ataccttgat     2280

ggtttatctc atggagcacc tttgctgaag cagctttgtg atcacatttt atttaaccca     2340

gccatctgga tacatacacc tgcaaaggtt cagctttccc tatacacata tttgtctgct     2400

gaatttattg gaactgctac catctacacc accatacgca gagtaggaac agtattacag     2460

ctaatgcaca ccttaaaata ttactactgg gttattaatc ctgctgacag tagtggcatt     2520

acacctaaag gattagatgg tccccggcca tcacaaaaag aaattatatc actgagggca     2580

tttatgctac tttttctgaa acagctgata ctaaaggatc gaggggtcaa ggaagatgaa     2640

cttcagagta tattaaatta cctacttacg atgcatgagg atgaaaatat tcatgatgtg     2700

ctacagttac tggtggcttt aatgtcggaa cacccagcct caatgatacc agcatttgat     2760

caaagaaatg gaataagggt gatctacaaa ttattggctt ctaaaagtga aagtatttgg     2820

gttcaagctt tgaaggttct gggatacttt ctgaagcatt taggtcacaa gagaaaagtt     2880

gaaattatgc acacccatag tcttttcact cttcttggag aaaggctgat gttgcataca     2940

aacactgtga ctgtcaccac atacaacaca ctttatgaga tcttgacaga acaagtatgt     3000

actcaggtcg tacacaaacc acatccagag ccagattcta cagtgaaaat tcagaatcca     3060

atgattctta aagtggtggc aactttgtta aaaaactcta caccaagtgc agagctgatg     3120

gaagttcgtc gtttattttt atctgatatg ataaaacttt tcagtaacag ccgtgaaaat     3180

agaagatgct tattgcagtg ttcagtgtgg caggattgga tgttttctct tggctatatc     3240

aatcctaaaa attctgagga acagaagatt accgaaatgg tctacaatat cttccggatt     3300

cttttgtatc atgcaataaa atatgaatgg ggaggctgga gagtctgggt ggataccctc     3360

tcaatagccc attccaaggt cacttatgaa gctcataagg aatacctagc caaaatgtat     3420

gaggaatatc aaagacaaga ggaggaaaac attaaaaagg gaaagaaagg gaatgtgagc     3480

accatctctg gtctttcatc acagacaaca ggagcaaaag gtggaatgga aattcgagag     3540

atagaagatc tttcacaaag ccagagccca gaaagtgaga ccgattaccc tgtcagcaca     3600

gatactcgag acttactcat gtcaacaaaa gtgtcagatg atattcttgg aaattcagat     3660

agaccaggaa gtggtgtaca tgtggaagta catgatcttt tagtagatat aaaagcagag     3720

aaagtggaag caacagaagt aaagctcgat gatatggatt tatcaccgga gactttagta     3780

ggtggagaga atggtgccct tgtggaggtt gaatctctgt tggataatgt atatagtgct     3840

gctgttgaga aactccagaa caatgtacat ggaagtgttg gtatcattaa aaaaaatgaa     3900

gaaaaggata atggtccatt gataacatta gcagatgaga aagaagacct tcccaatagt     3960

agtacatcat ttctctttga taaaataccc aaacaggagg aaaaactact tcctgaactt     4020

tctagcaatc acattattcc aaatattcag gacacacaag tacatcttgg tgttagtgat     4080

gatcttggat tgcttgctca catgaccggt agcgtagact taacttgtac atccagtata     4140

atagaagaaa aagaattcaa aatccataca acttcagatg gaatgagcag tatttctgaa     4200

agagacttag cgtcatcaac taaggggctg gagtatgctg aaatgactgc tacaactctg     4260

gaaactgagt cttctagtag caaaattgta ccaaatattg atgcaggaag tataatttca     4320

gatactgaaa ggtctgacga tggcaaagaa tcaggaaaag aaatccgaaa aatccaaaca     4380

actactacga cacaagctgt gcagggtcgg tctatcaccc aacaagaccg agatctccga     4440

gttgatttag gatttcgagg aatgccaatg actgaggaac agcgacgcca gtttagccca     4500

ggtccacgga ctacaatgtt tcgtattcct gagtttaaat ggtctccaat gcaccagcgg     4560

cttctcactg atttactatt tgcattagaa actgatgtac atgtttggag gagccattct     4620

acaaagtctg taatggattt tgtcaatagc aatgaaaata ttatttttgt acataacaca     4680

attcacctca tttcccaaat ggtagacaac atcatcattg cttgtggagg aattttacct     4740

ttgctctctg ctgctacatc accaactggt tctaagacgg aattggaaaa tattgaagtg     4800

acacaaggca tgtcagctga gacagcagta actttcctca gccggctgat ggctatggtt     4860

gatgtacttg tgtttgcaag ctctctaaat tttagtgaga ttgaagctga gaaaaacatg     4920

tcttctggag gtttaatgcg acagtgccta agattagttt gttgtgttgc tgtgagaaac     4980

tgtttagaat gtcggcaaag acagagagac aggggaaata aatcttccca tggaagcagt     5040

aaacctcagg aagttcctca aagtgtgact gctacagcag cttcgaagac tccattggaa     5100

aatgttccag gtaacctttc tcctattaag gatccggata gacttcttca ggatgttgat     5160

atcaatcgcc ttcgtgctgt tgtctttcgg gatgtggatg atagcaaaca agcacagttc     5220

ttagctctgg ctgttgttta cttcatttcg gttctgatgg tttccaagta tcgtgacata     5280

ttagaacccc agagagagac tacaagaact ggaagccaac caggtagaaa catcaggcaa     5340

gaaataaatt caccaacaag tacagttgtg gtcataccat ctatccctca tccaagtttg     5400

aaccatggat tccttgccaa gttaattcct gagcagagct ttggccactc attttacaaa     5460

gaaacacctg ctgcatttcc agacaccata aaagaaaaag aaacaccaac tcctggtgaa     5520

gatattcagg tagaaagttc aattccccat acagattcag gaattggaga ggagcaagtg     5580

gctagcatcc tgaatggggc agaattagaa acaagtacag gccctgatgc catgagtgaa     5640

ctcttatcca ctttgtcatc cgaagtgaag aaatcacaag agagcttaac tgaaaatcct     5700

agtgaaacgt tgaagcctgc aacatccata tctagcatta gtcaaaccaa aggcatcaat     5760

gtgaaggaaa tactgaaaag tcttgtggct gctccagttg aaatagcaga atgtggccct     5820

gaacctatcc catacccaga tccagcattg aagagagaaa cacaagctat tcttcctatg     5880

cagtttcatt cctttgacag gagtgttgtg gtgcctgtaa agaaaccacc tccaggtagt     5940

ttagctgtaa ccactgtggg agccactact gctggaagtg ggctgccaac aggcagtacc     6000

tctaatatat ttgctgctac tggagctaca ccaaaaagta tgattaatac aacaggtgcc     6060

gtggattcag ggtcctcctc ctcttcctcc tcttctagtt ttgtgaatgg tgctactagc     6120

aaaaaccttc cagctgtaca aactgttgct ccaatgccag aagattcagc tgaaaatatg     6180

agcatcactg caaaacttga aagagcgtta gaaaaagttg ctcctcttct tcgtgaaatt     6240

tttgtagact ttgccccatt cctatctcgt acacttcttg gcagtcatgg acaagagcta     6300

ttgatagaag gccttgtttg tatgaagtcc agcacatctg tggttgagct tgttatgctg     6360

ctttgttctc aggaatggca aaactctatt cagaagaatg caggacttgc atttattgag     6420

ctcatcaatg aaggaagatt actgtgccat gctatgaagg accatatagt ccgtgttgca     6480

aatgaagctg agtttatttt gaacagacaa agagccgagg atgtacataa acatgcagag     6540

tttgagtcac agtgtgccca atatgctgct gatagaagag aggaagaaaa gatgtgtgac     6600

catcttatca gtgctgctaa acatcgagat catgtaacag caaatcagct gaaacagaag     6660

attctcaata ttctcacaaa taaacatggt gcttggggag cagtttctca tagccaattg     6720

catgatttct ggcgtttgga ttactgggaa gatgatcttc gtcgaaggag acgatttgtt     6780

cgcaatgcat ttggctccac tcatgctgaa gcattgctga aagctgcaat agaatatggc     6840

acggaagaag atgtagtaaa gtcaaagaaa acattcagaa gtcaagcaat agtgaaccaa     6900

aatgcagaga cagaacttat gctggaagga gacgatgatg cagtcagtct gctacaggag     6960

aaagaaattg acaaccttgc aggcccagtg gttctcagca cccctgccca gctcatcgct     7020

cccgtggtgg tggccaaggg gactctctcc atcaccacga cagaaatcta cttcgaggta     7080

gatgaggatg attctgcctt caagaagatc gacacgaaag ttcttgcata cactgaggga     7140

cttcacggaa aatggatgtt cagcgagata cgagctgtat tttcaagacg ttaccttcta     7200

caaaacactg ctttggaagt atttatggca aaccgaacct cagttatgtt taatttccct     7260

gatcaagcaa cagtaaaaaa agttgtctat agcttgcctc gggttggagt agggaccagc     7320

tatggtctgc cacaagccag gaggatatca ttggccactc ctcgacagct ttataaatct     7380

tccaatatga ctcagcgctg gcaaagaagg gaaatttcaa acttcgaata tttgatgttc     7440

cttaatacta ttgcaggacg gacatataat gatctgaacc aatatccagt gtttccgtgg     7500

gtgttaacca actatgaatc agaagagttg gacctgactc ttccaggaaa cttcagggat     7560

ctatcaaagc caattggtgc tttgaacccc aagagagctg tgttttatgc agagcgttat     7620

gagacatggg aagatgatca aagcccaccc taccattata atacccatta ttcaacagca     7680

acatctactt tatcctggct tgttcgaatt gaacctttca caaccttctt cctcaatgca     7740

aatgatggaa aatttgatca tccagatcga accttctcat ccgttgcaag gtcttggaga     7800

actagtcaga gagatacttc tgatgtaaag gaactaattc cagagttcta ctacctacca     7860

gagatgtttg tcaacagtaa tggatataat cttggagtca gagaagatga agtagtggta     7920

aatgatgttg atcttccccc ttgggcaaaa aaacctgaag actttgtgcg gatcaacagg     7980

atggccctag aaagtgaatt tgtttcttgc caacttcatc agtggatcga ccttatattt     8040

ggctataagc agcgaggacc agaagcagtt cgtgctctga atgtttttca ctacttgact     8100

tatgaaggct ctgtgaacct ggatagtatc actgatcctg tgctcaggga ggccatggag     8160

gcacagatac agaactttgg acagacgcca tctcagttgc ttattgagcc acatccgcct     8220

cggagctctg ccatgcacct gtgtttcctt ccacagagtc cgctcatgtt taaagatcag     8280

atgcaacagg atgtgataat ggtgctgaag tttccttcaa attctccagt aacccatgtg     8340

gcagccaaca ctctgcccca cttgaccatc cccgcagtgg tgacagtgac ttgcagccga     8400

ctctttgcag tgaatagatg gcacaacaca gtaggcctca gaggagctcc aggatactcc     8460

ttggatcaag cccaccatct tcccattgaa atggatccat taatagccaa taattcaggt     8520

gtaaacaaac ggcagatcac agacctcgtt gaccagagta tacaaatcaa tgcacattgt     8580

tttgtggtaa cagcagataa tcgctatatt cttatctgtg gattctggga taagagcttc     8640

agagtttatt ctacagaaac agggaaattg actcagattg tatttggcca ttgggatgtg     8700

gtcacttgct tggccaggtc cgagtcatac attggtgggg actgctacat cgtgtccgga     8760

tctcgagatg ccaccctgct gctctggtac tggagtgggc ggcaccatat cataggagac     8820

aaccctaaca gcagtgacta tccggcacca agagccgtcc tcacaggcca tgaccatgaa     8880

gttgtctgtg tttctgtctg tgcagaactt gggcttgtta tcagtggtgc taaagagggc     8940

ccttgccttg tccacaccat cactggagat ttgctgagag cccttgaagg accagaaaac     9000

tgcttattcc cacgcttgat atctgtctcc agcgaaggcc actgtatcat atactatgaa     9060

cgagggcgat tcagtaattt cagcattaat gggaaacttt tggctcaaat ggagatcaat     9120

gattcaacac gggccattct cctgagcagt gacggccaga acctggtcac cggaggggac     9180

aatggggtag tagaggtctg gcaggcctgt gacttcaagc aactgtacat ttaccctgga     9240

tgtgatgctg gcattagagc aatggacttg tcccatgacc agaggactct gatcactggc     9300

atggcttctg gtagcattgt agcttttaat atagatttta atcggtggca ttatgagcat     9360

cagaacagat actgaagata aaggaagaac caaaagccaa gttaaagctg agagcacaag     9420

tgctgcatgg aaaggcaata tctctggtgg aaaaaactcg tctacatcga cctccgtttg     9480

tacattccat cacacccagc aatagctgta cattgtagtc agcaaccatt ttactttgtg     9540

tgttttttca cgactgaaca ccagctgcta tcaagcaagc ttatatcatg taaattatat     9600

gaattaggag atgttttggt aattatttca tatattgttg tttattgaga aaaggttgta     9660

ggatgtgtca caagagactt ttgacaattc tgaggaacct tgtgtccagt tgttacaaag     9720

tttaagcttt gaacctaacc tgcatcccat ttccagcctc ttttcaagct gagaaaaaaa     9780

aaaaaaaaca cgtttgatac tttgtacatc agatgcatct tatttaaaag ggatactttt     9840

gtaaaagtaa aaccttgtat aaagaacaaa atgtttctta attttattgt ggagttacaa     9900

cttgcatgtt ccttactcct gttggcttga tggaacaggt gcattcacac tatgaaacag     9960

aaagatctgt ccaaggacac agcttgtatg aaagggttga atttgggctc catcagtaat    10020

ttttgacatt ttcaccaaaa tatagtttgc actttttaat ctaaagtcat cccttctgag    10080

tgaaatttgc tcataaagca tttggatact aagccattat ttgccatttt gggtacttta    10140

tacaaagaaa attcagccct accctgcata atttgaagac acagcagaaa gggggcttag    10200

ggatgaggtc ctggtttttc ttgtataaat aggagtcatg ggcgttagtt ctgtagtaat    10260

aacttcccag cacctggaca tctcttccag agttatccca ctggcttggt gtgtatacat    10320

taggggagga taatctgatg ctaacttttt ttttctcttt ggttcttgaa tagcttagtt    10380

tctttaataa caagtcaaac tttattacaa caataactga agttattctt ttaggttctc    10440

gtgaaattct cactgaaagc cacattctta gcctaaggca tttcatcttt tatgatataa    10500

aatgatggct atcaaatgat tttccataca ttgtactgat caagttatac acccaggggt    10560

atatacactt tcttcatgtt tcttctttgt atatttggtg actgtatcgt catagatgta    10620

catattgtgt cggtagggct atgaggcatg ttacaggaat gtaattttct cagaatttac    10680

actcactcgc agtcatttat ttaaaaagat aaaacaagat aatgggttct ttgtattggc    10740

actttgcacc agaaacatat cattatttat tgatgtgatt acttatttgt tatccacctt    10800

gtactagtaa gttttagcac tgaattcctt cttcactgtt gtttgtattt atgaaattct    10860

gaaattatgg ggaatcagcg taatgattaa gttattcatc accaggctgt aagcaatatc    10920

ttgagtttgt agcttagaat tgggaggata cttaacatct ggaagacaag ttcatttcat    10980

cttgagatca tggtgaaata ttttggatat ataaattcct taagctattg taaccatgtt    11040

ttattgcaaa gatgtaaaat atgccagatg tgtgtgagtt ggaaatcaaa aaaagaaaaa    11100

taaaatatgc aaagaattca aaaaaaaaaa aaaaaaaaaa                          11140


<210>  66
<211>  2946
<212>  PRT
<213>  Homo sapiens

<400>  66

Met Ala Ser Glu Lys Pro Gly Pro Gly Pro Gly Leu Glu Pro Gln Pro 
1               5                   10                  15      


Val Gly Leu Ile Ala Val Gly Ala Ala Gly Gly Gly Gly Gly Gly Ser 
            20                  25                  30          


Gly Gly Gly Gly Thr Gly Gly Ser Gly Met Gly Glu Leu Arg Gly Ala 
        35                  40                  45              


Ser Gly Ser Gly Ser Val Met Leu Pro Ala Gly Met Ile Asn Pro Ser 
    50                  55                  60                  


Val Pro Ile Arg Asn Ile Arg Met Lys Phe Ala Val Leu Ile Gly Leu 
65                  70                  75                  80  


Ile Gln Val Gly Glu Val Ser Asn Arg Asp Ile Val Glu Thr Val Leu 
                85                  90                  95      


Asn Leu Leu Val Gly Gly Glu Phe Asp Leu Glu Met Asn Phe Ile Ile 
            100                 105                 110         


Gln Asp Ala Glu Ser Ile Thr Cys Met Thr Glu Leu Leu Glu His Cys 
        115                 120                 125             


Asp Val Thr Cys Gln Ala Glu Ile Trp Ser Met Phe Thr Ala Ile Leu 
    130                 135                 140                 


Arg Lys Ser Val Arg Asn Leu Gln Thr Ser Thr Glu Val Gly Leu Ile 
145                 150                 155                 160 


Glu Gln Val Leu Leu Lys Met Ser Ala Val Asp Asp Met Ile Ala Asp 
                165                 170                 175     


Leu Leu Val Asp Met Leu Gly Val Leu Ala Ser Tyr Ser Ile Thr Val 
            180                 185                 190         


Lys Glu Leu Lys Leu Leu Phe Ser Met Leu Arg Gly Glu Ser Gly Ile 
        195                 200                 205             


Trp Pro Arg His Ala Val Lys Leu Leu Ser Val Leu Asn Gln Met Pro 
    210                 215                 220                 


Gln Arg His Gly Pro Asp Thr Phe Phe Asn Phe Pro Gly Cys Ser Ala 
225                 230                 235                 240 


Ala Ala Ile Ala Leu Pro Pro Ile Ala Lys Trp Pro Tyr Gln Asn Gly 
                245                 250                 255     


Phe Thr Leu Asn Thr Trp Phe Arg Met Asp Pro Leu Asn Asn Ile Asn 
            260                 265                 270         


Val Asp Lys Asp Lys Pro Tyr Leu Tyr Cys Phe Arg Thr Ser Lys Gly 
        275                 280                 285             


Val Gly Tyr Ser Ala His Phe Val Gly Asn Cys Leu Ile Val Thr Ser 
    290                 295                 300                 


Leu Lys Ser Lys Gly Lys Gly Phe Gln His Cys Val Lys Tyr Asp Phe 
305                 310                 315                 320 


Gln Pro Arg Lys Trp Tyr Met Ile Ser Ile Val His Ile Tyr Asn Arg 
                325                 330                 335     


Trp Arg Asn Ser Glu Ile Arg Cys Tyr Val Asn Gly Gln Leu Val Ser 
            340                 345                 350         


Tyr Gly Asp Met Ala Trp His Val Asn Thr Asn Asp Ser Tyr Asp Lys 
        355                 360                 365             


Cys Phe Leu Gly Ser Ser Glu Thr Ala Asp Ala Asn Arg Val Phe Cys 
    370                 375                 380                 


Gly Gln Leu Gly Ala Val Tyr Val Phe Ser Glu Ala Leu Asn Pro Ala 
385                 390                 395                 400 


Gln Ile Phe Ala Ile His Gln Leu Gly Pro Gly Tyr Lys Ser Thr Phe 
                405                 410                 415     


Lys Phe Lys Ser Glu Ser Asp Ile His Leu Ala Glu His His Lys Gln 
            420                 425                 430         


Val Leu Tyr Asp Gly Lys Leu Ala Ser Ser Ile Ala Phe Thr Tyr Asn 
        435                 440                 445             


Ala Lys Ala Thr Asp Ala Gln Leu Cys Leu Glu Ser Ser Pro Lys Glu 
    450                 455                 460                 


Asn Ala Ser Ile Phe Val His Ser Pro His Ala Leu Met Leu Gln Asp 
465                 470                 475                 480 


Val Lys Ala Ile Val Thr His Ser Ile His Ser Ala Ile His Ser Ile 
                485                 490                 495     


Gly Gly Ile Gln Val Leu Phe Pro Leu Phe Ala Gln Leu Asp Asn Arg 
            500                 505                 510         


Gln Leu Asn Asp Ser Gln Val Glu Thr Thr Val Cys Ala Thr Leu Leu 
        515                 520                 525             


Ala Phe Leu Val Glu Leu Leu Lys Ser Ser Val Ala Met Gln Glu Gln 
    530                 535                 540                 


Met Leu Gly Gly Lys Gly Phe Leu Val Ile Gly Tyr Leu Leu Glu Lys 
545                 550                 555                 560 


Ser Ser Arg Val His Ile Thr Arg Ala Val Leu Glu Gln Phe Leu Ser 
                565                 570                 575     


Phe Ala Lys Tyr Leu Asp Gly Leu Ser His Gly Ala Pro Leu Leu Lys 
            580                 585                 590         


Gln Leu Cys Asp His Ile Leu Phe Asn Pro Ala Ile Trp Ile His Thr 
        595                 600                 605             


Pro Ala Lys Val Gln Leu Ser Leu Tyr Thr Tyr Leu Ser Ala Glu Phe 
    610                 615                 620                 


Ile Gly Thr Ala Thr Ile Tyr Thr Thr Ile Arg Arg Val Gly Thr Val 
625                 630                 635                 640 


Leu Gln Leu Met His Thr Leu Lys Tyr Tyr Tyr Trp Val Ile Asn Pro 
                645                 650                 655     


Ala Asp Ser Ser Gly Ile Thr Pro Lys Gly Leu Asp Gly Pro Arg Pro 
            660                 665                 670         


Ser Gln Lys Glu Ile Ile Ser Leu Arg Ala Phe Met Leu Leu Phe Leu 
        675                 680                 685             


Lys Gln Leu Ile Leu Lys Asp Arg Gly Val Lys Glu Asp Glu Leu Gln 
    690                 695                 700                 


Ser Ile Leu Asn Tyr Leu Leu Thr Met His Glu Asp Glu Asn Ile His 
705                 710                 715                 720 


Asp Val Leu Gln Leu Leu Val Ala Leu Met Ser Glu His Pro Ala Ser 
                725                 730                 735     


Met Ile Pro Ala Phe Asp Gln Arg Asn Gly Ile Arg Val Ile Tyr Lys 
            740                 745                 750         


Leu Leu Ala Ser Lys Ser Glu Ser Ile Trp Val Gln Ala Leu Lys Val 
        755                 760                 765             


Leu Gly Tyr Phe Leu Lys His Leu Gly His Lys Arg Lys Val Glu Ile 
    770                 775                 780                 


Met His Thr His Ser Leu Phe Thr Leu Leu Gly Glu Arg Leu Met Leu 
785                 790                 795                 800 


His Thr Asn Thr Val Thr Val Thr Thr Tyr Asn Thr Leu Tyr Glu Ile 
                805                 810                 815     


Leu Thr Glu Gln Val Cys Thr Gln Val Val His Lys Pro His Pro Glu 
            820                 825                 830         


Pro Asp Ser Thr Val Lys Ile Gln Asn Pro Met Ile Leu Lys Val Val 
        835                 840                 845             


Ala Thr Leu Leu Lys Asn Ser Thr Pro Ser Ala Glu Leu Met Glu Val 
    850                 855                 860                 


Arg Arg Leu Phe Leu Ser Asp Met Ile Lys Leu Phe Ser Asn Ser Arg 
865                 870                 875                 880 


Glu Asn Arg Arg Cys Leu Leu Gln Cys Ser Val Trp Gln Asp Trp Met 
                885                 890                 895     


Phe Ser Leu Gly Tyr Ile Asn Pro Lys Asn Ser Glu Glu Gln Lys Ile 
            900                 905                 910         


Thr Glu Met Val Tyr Asn Ile Phe Arg Ile Leu Leu Tyr His Ala Ile 
        915                 920                 925             


Lys Tyr Glu Trp Gly Gly Trp Arg Val Trp Val Asp Thr Leu Ser Ile 
    930                 935                 940                 


Ala His Ser Lys Val Thr Tyr Glu Ala His Lys Glu Tyr Leu Ala Lys 
945                 950                 955                 960 


Met Tyr Glu Glu Tyr Gln Arg Gln Glu Glu Glu Asn Ile Lys Lys Gly 
                965                 970                 975     


Lys Lys Gly Asn Val Ser Thr Ile Ser Gly Leu Ser Ser Gln Thr Thr 
            980                 985                 990         


Gly Ala Lys Gly Gly Met Glu Ile  Arg Glu Ile Glu Asp  Leu Ser Gln 
        995                 1000                 1005             


Ser Gln  Ser Pro Glu Ser Glu  Thr Asp Tyr Pro Val  Ser Thr Asp 
    1010                 1015                 1020             


Thr Arg  Asp Leu Leu Met Ser  Thr Lys Val Ser Asp  Asp Ile Leu 
    1025                 1030                 1035             


Gly Asn  Ser Asp Arg Pro Gly  Ser Gly Val His Val  Glu Val His 
    1040                 1045                 1050             


Asp Leu  Leu Val Asp Ile Lys  Ala Glu Lys Val Glu  Ala Thr Glu 
    1055                 1060                 1065             


Val Lys  Leu Asp Asp Met Asp  Leu Ser Pro Glu Thr  Leu Val Gly 
    1070                 1075                 1080             


Gly Glu  Asn Gly Ala Leu Val  Glu Val Glu Ser Leu  Leu Asp Asn 
    1085                 1090                 1095             


Val Tyr  Ser Ala Ala Val Glu  Lys Leu Gln Asn Asn  Val His Gly 
    1100                 1105                 1110             


Ser Val  Gly Ile Ile Lys Lys  Asn Glu Glu Lys Asp  Asn Gly Pro 
    1115                 1120                 1125             


Leu Ile  Thr Leu Ala Asp Glu  Lys Glu Asp Leu Pro  Asn Ser Ser 
    1130                 1135                 1140             


Thr Ser  Phe Leu Phe Asp Lys  Ile Pro Lys Gln Glu  Glu Lys Leu 
    1145                 1150                 1155             


Leu Pro  Glu Leu Ser Ser Asn  His Ile Ile Pro Asn  Ile Gln Asp 
    1160                 1165                 1170             


Thr Gln  Val His Leu Gly Val  Ser Asp Asp Leu Gly  Leu Leu Ala 
    1175                 1180                 1185             


His Met  Thr Gly Ser Val Asp  Leu Thr Cys Thr Ser  Ser Ile Ile 
    1190                 1195                 1200             


Glu Glu  Lys Glu Phe Lys Ile  His Thr Thr Ser Asp  Gly Met Ser 
    1205                 1210                 1215             


Ser Ile  Ser Glu Arg Asp Leu  Ala Ser Ser Thr Lys  Gly Leu Glu 
    1220                 1225                 1230             


Tyr Ala  Glu Met Thr Ala Thr  Thr Leu Glu Thr Glu  Ser Ser Ser 
    1235                 1240                 1245             


Ser Lys  Ile Val Pro Asn Ile  Asp Ala Gly Ser Ile  Ile Ser Asp 
    1250                 1255                 1260             


Thr Glu  Arg Ser Asp Asp Gly  Lys Glu Ser Gly Lys  Glu Ile Arg 
    1265                 1270                 1275             


Lys Ile  Gln Thr Thr Thr Thr  Thr Gln Ala Val Gln  Gly Arg Ser 
    1280                 1285                 1290             


Ile Thr  Gln Gln Asp Arg Asp  Leu Arg Val Asp Leu  Gly Phe Arg 
    1295                 1300                 1305             


Gly Met  Pro Met Thr Glu Glu  Gln Arg Arg Gln Phe  Ser Pro Gly 
    1310                 1315                 1320             


Pro Arg  Thr Thr Met Phe Arg  Ile Pro Glu Phe Lys  Trp Ser Pro 
    1325                 1330                 1335             


Met His  Gln Arg Leu Leu Thr  Asp Leu Leu Phe Ala  Leu Glu Thr 
    1340                 1345                 1350             


Asp Val  His Val Trp Arg Ser  His Ser Thr Lys Ser  Val Met Asp 
    1355                 1360                 1365             


Phe Val  Asn Ser Asn Glu Asn  Ile Ile Phe Val His  Asn Thr Ile 
    1370                 1375                 1380             


His Leu  Ile Ser Gln Met Val  Asp Asn Ile Ile Ile  Ala Cys Gly 
    1385                 1390                 1395             


Gly Ile  Leu Pro Leu Leu Ser  Ala Ala Thr Ser Pro  Thr Gly Ser 
    1400                 1405                 1410             


Lys Thr  Glu Leu Glu Asn Ile  Glu Val Thr Gln Gly  Met Ser Ala 
    1415                 1420                 1425             


Glu Thr  Ala Val Thr Phe Leu  Ser Arg Leu Met Ala  Met Val Asp 
    1430                 1435                 1440             


Val Leu  Val Phe Ala Ser Ser  Leu Asn Phe Ser Glu  Ile Glu Ala 
    1445                 1450                 1455             


Glu Lys  Asn Met Ser Ser Gly  Gly Leu Met Arg Gln  Cys Leu Arg 
    1460                 1465                 1470             


Leu Val  Cys Cys Val Ala Val  Arg Asn Cys Leu Glu  Cys Arg Gln 
    1475                 1480                 1485             


Arg Gln  Arg Asp Arg Gly Asn  Lys Ser Ser His Gly  Ser Ser Lys 
    1490                 1495                 1500             


Pro Gln  Glu Val Pro Gln Ser  Val Thr Ala Thr Ala  Ala Ser Lys 
    1505                 1510                 1515             


Thr Pro  Leu Glu Asn Val Pro  Gly Asn Leu Ser Pro  Ile Lys Asp 
    1520                 1525                 1530             


Pro Asp  Arg Leu Leu Gln Asp  Val Asp Ile Asn Arg  Leu Arg Ala 
    1535                 1540                 1545             


Val Val  Phe Arg Asp Val Asp  Asp Ser Lys Gln Ala  Gln Phe Leu 
    1550                 1555                 1560             


Ala Leu  Ala Val Val Tyr Phe  Ile Ser Val Leu Met  Val Ser Lys 
    1565                 1570                 1575             


Tyr Arg  Asp Ile Leu Glu Pro  Gln Arg Glu Thr Thr  Arg Thr Gly 
    1580                 1585                 1590             


Ser Gln  Pro Gly Arg Asn Ile  Arg Gln Glu Ile Asn  Ser Pro Thr 
    1595                 1600                 1605             


Ser Thr  Val Val Val Ile Pro  Ser Ile Pro His Pro  Ser Leu Asn 
    1610                 1615                 1620             


His Gly  Phe Leu Ala Lys Leu  Ile Pro Glu Gln Ser  Phe Gly His 
    1625                 1630                 1635             


Ser Phe  Tyr Lys Glu Thr Pro  Ala Ala Phe Pro Asp  Thr Ile Lys 
    1640                 1645                 1650             


Glu Lys  Glu Thr Pro Thr Pro  Gly Glu Asp Ile Gln  Val Glu Ser 
    1655                 1660                 1665             


Ser Ile  Pro His Thr Asp Ser  Gly Ile Gly Glu Glu  Gln Val Ala 
    1670                 1675                 1680             


Ser Ile  Leu Asn Gly Ala Glu  Leu Glu Thr Ser Thr  Gly Pro Asp 
    1685                 1690                 1695             


Ala Met  Ser Glu Leu Leu Ser  Thr Leu Ser Ser Glu  Val Lys Lys 
    1700                 1705                 1710             


Ser Gln  Glu Ser Leu Thr Glu  Asn Pro Ser Glu Thr  Leu Lys Pro 
    1715                 1720                 1725             


Ala Thr  Ser Ile Ser Ser Ile  Ser Gln Thr Lys Gly  Ile Asn Val 
    1730                 1735                 1740             


Lys Glu  Ile Leu Lys Ser Leu  Val Ala Ala Pro Val  Glu Ile Ala 
    1745                 1750                 1755             


Glu Cys  Gly Pro Glu Pro Ile  Pro Tyr Pro Asp Pro  Ala Leu Lys 
    1760                 1765                 1770             


Arg Glu  Thr Gln Ala Ile Leu  Pro Met Gln Phe His  Ser Phe Asp 
    1775                 1780                 1785             


Arg Ser  Val Val Val Pro Val  Lys Lys Pro Pro Pro  Gly Ser Leu 
    1790                 1795                 1800             


Ala Val  Thr Thr Val Gly Ala  Thr Thr Ala Gly Ser  Gly Leu Pro 
    1805                 1810                 1815             


Thr Gly  Ser Thr Ser Asn Ile  Phe Ala Ala Thr Gly  Ala Thr Pro 
    1820                 1825                 1830             


Lys Ser  Met Ile Asn Thr Thr  Gly Ala Val Asp Ser  Gly Ser Ser 
    1835                 1840                 1845             


Ser Ser  Ser Ser Ser Ser Ser  Phe Val Asn Gly Ala  Thr Ser Lys 
    1850                 1855                 1860             


Asn Leu  Pro Ala Val Gln Thr  Val Ala Pro Met Pro  Glu Asp Ser 
    1865                 1870                 1875             


Ala Glu  Asn Met Ser Ile Thr  Ala Lys Leu Glu Arg  Ala Leu Glu 
    1880                 1885                 1890             


Lys Val  Ala Pro Leu Leu Arg  Glu Ile Phe Val Asp  Phe Ala Pro 
    1895                 1900                 1905             


Phe Leu  Ser Arg Thr Leu Leu  Gly Ser His Gly Gln  Glu Leu Leu 
    1910                 1915                 1920             


Ile Glu  Gly Leu Val Cys Met  Lys Ser Ser Thr Ser  Val Val Glu 
    1925                 1930                 1935             


Leu Val  Met Leu Leu Cys Ser  Gln Glu Trp Gln Asn  Ser Ile Gln 
    1940                 1945                 1950             


Lys Asn  Ala Gly Leu Ala Phe  Ile Glu Leu Ile Asn  Glu Gly Arg 
    1955                 1960                 1965             


Leu Leu  Cys His Ala Met Lys  Asp His Ile Val Arg  Val Ala Asn 
    1970                 1975                 1980             


Glu Ala  Glu Phe Ile Leu Asn  Arg Gln Arg Ala Glu  Asp Val His 
    1985                 1990                 1995             


Lys His  Ala Glu Phe Glu Ser  Gln Cys Ala Gln Tyr  Ala Ala Asp 
    2000                 2005                 2010             


Arg Arg  Glu Glu Glu Lys Met  Cys Asp His Leu Ile  Ser Ala Ala 
    2015                 2020                 2025             


Lys His  Arg Asp His Val Thr  Ala Asn Gln Leu Lys  Gln Lys Ile 
    2030                 2035                 2040             


Leu Asn  Ile Leu Thr Asn Lys  His Gly Ala Trp Gly  Ala Val Ser 
    2045                 2050                 2055             


His Ser  Gln Leu His Asp Phe  Trp Arg Leu Asp Tyr  Trp Glu Asp 
    2060                 2065                 2070             


Asp Leu  Arg Arg Arg Arg Arg  Phe Val Arg Asn Ala  Phe Gly Ser 
    2075                 2080                 2085             


Thr His  Ala Glu Ala Leu Leu  Lys Ala Ala Ile Glu  Tyr Gly Thr 
    2090                 2095                 2100             


Glu Glu  Asp Val Val Lys Ser  Lys Lys Thr Phe Arg  Ser Gln Ala 
    2105                 2110                 2115             


Ile Val  Asn Gln Asn Ala Glu  Thr Glu Leu Met Leu  Glu Gly Asp 
    2120                 2125                 2130             


Asp Asp  Ala Val Ser Leu Leu  Gln Glu Lys Glu Ile  Asp Asn Leu 
    2135                 2140                 2145             


Ala Gly  Pro Val Val Leu Ser  Thr Pro Ala Gln Leu  Ile Ala Pro 
    2150                 2155                 2160             


Val Val  Val Ala Lys Gly Thr  Leu Ser Ile Thr Thr  Thr Glu Ile 
    2165                 2170                 2175             


Tyr Phe  Glu Val Asp Glu Asp  Asp Ser Ala Phe Lys  Lys Ile Asp 
    2180                 2185                 2190             


Thr Lys  Val Leu Ala Tyr Thr  Glu Gly Leu His Gly  Lys Trp Met 
    2195                 2200                 2205             


Phe Ser  Glu Ile Arg Ala Val  Phe Ser Arg Arg Tyr  Leu Leu Gln 
    2210                 2215                 2220             


Asn Thr  Ala Leu Glu Val Phe  Met Ala Asn Arg Thr  Ser Val Met 
    2225                 2230                 2235             


Phe Asn  Phe Pro Asp Gln Ala  Thr Val Lys Lys Val  Val Tyr Ser 
    2240                 2245                 2250             


Leu Pro  Arg Val Gly Val Gly  Thr Ser Tyr Gly Leu  Pro Gln Ala 
    2255                 2260                 2265             


Arg Arg  Ile Ser Leu Ala Thr  Pro Arg Gln Leu Tyr  Lys Ser Ser 
    2270                 2275                 2280             


Asn Met  Thr Gln Arg Trp Gln  Arg Arg Glu Ile Ser  Asn Phe Glu 
    2285                 2290                 2295             


Tyr Leu  Met Phe Leu Asn Thr  Ile Ala Gly Arg Thr  Tyr Asn Asp 
    2300                 2305                 2310             


Leu Asn  Gln Tyr Pro Val Phe  Pro Trp Val Leu Thr  Asn Tyr Glu 
    2315                 2320                 2325             


Ser Glu  Glu Leu Asp Leu Thr  Leu Pro Gly Asn Phe  Arg Asp Leu 
    2330                 2335                 2340             


Ser Lys  Pro Ile Gly Ala Leu  Asn Pro Lys Arg Ala  Val Phe Tyr 
    2345                 2350                 2355             


Ala Glu  Arg Tyr Glu Thr Trp  Glu Asp Asp Gln Ser  Pro Pro Tyr 
    2360                 2365                 2370             


His Tyr  Asn Thr His Tyr Ser  Thr Ala Thr Ser Thr  Leu Ser Trp 
    2375                 2380                 2385             


Leu Val  Arg Ile Glu Pro Phe  Thr Thr Phe Phe Leu  Asn Ala Asn 
    2390                 2395                 2400             


Asp Gly  Lys Phe Asp His Pro  Asp Arg Thr Phe Ser  Ser Val Ala 
    2405                 2410                 2415             


Arg Ser  Trp Arg Thr Ser Gln  Arg Asp Thr Ser Asp  Val Lys Glu 
    2420                 2425                 2430             


Leu Ile  Pro Glu Phe Tyr Tyr  Leu Pro Glu Met Phe  Val Asn Ser 
    2435                 2440                 2445             


Asn Gly  Tyr Asn Leu Gly Val  Arg Glu Asp Glu Val  Val Val Asn 
    2450                 2455                 2460             


Asp Val  Asp Leu Pro Pro Trp  Ala Lys Lys Pro Glu  Asp Phe Val 
    2465                 2470                 2475             


Arg Ile  Asn Arg Met Ala Leu  Glu Ser Glu Phe Val  Ser Cys Gln 
    2480                 2485                 2490             


Leu His  Gln Trp Ile Asp Leu  Ile Phe Gly Tyr Lys  Gln Arg Gly 
    2495                 2500                 2505             


Pro Glu  Ala Val Arg Ala Leu  Asn Val Phe His Tyr  Leu Thr Tyr 
    2510                 2515                 2520             


Glu Gly  Ser Val Asn Leu Asp  Ser Ile Thr Asp Pro  Val Leu Arg 
    2525                 2530                 2535             


Glu Ala  Met Glu Ala Gln Ile  Gln Asn Phe Gly Gln  Thr Pro Ser 
    2540                 2545                 2550             


Gln Leu  Leu Ile Glu Pro His  Pro Pro Arg Ser Ser  Ala Met His 
    2555                 2560                 2565             


Leu Cys  Phe Leu Pro Gln Ser  Pro Leu Met Phe Lys  Asp Gln Met 
    2570                 2575                 2580             


Gln Gln  Asp Val Ile Met Val  Leu Lys Phe Pro Ser  Asn Ser Pro 
    2585                 2590                 2595             


Val Thr  His Val Ala Ala Asn  Thr Leu Pro His Leu  Thr Ile Pro 
    2600                 2605                 2610             


Ala Val  Val Thr Val Thr Cys  Ser Arg Leu Phe Ala  Val Asn Arg 
    2615                 2620                 2625             


Trp His  Asn Thr Val Gly Leu  Arg Gly Ala Pro Gly  Tyr Ser Leu 
    2630                 2635                 2640             


Asp Gln  Ala His His Leu Pro  Ile Glu Met Asp Pro  Leu Ile Ala 
    2645                 2650                 2655             


Asn Asn  Ser Gly Val Asn Lys  Arg Gln Ile Thr Asp  Leu Val Asp 
    2660                 2665                 2670             


Gln Ser  Ile Gln Ile Asn Ala  His Cys Phe Val Val  Thr Ala Asp 
    2675                 2680                 2685             


Asn Arg  Tyr Ile Leu Ile Cys  Gly Phe Trp Asp Lys  Ser Phe Arg 
    2690                 2695                 2700             


Val Tyr  Ser Thr Glu Thr Gly  Lys Leu Thr Gln Ile  Val Phe Gly 
    2705                 2710                 2715             


His Trp  Asp Val Val Thr Cys  Leu Ala Arg Ser Glu  Ser Tyr Ile 
    2720                 2725                 2730             


Gly Gly  Asp Cys Tyr Ile Val  Ser Gly Ser Arg Asp  Ala Thr Leu 
    2735                 2740                 2745             


Leu Leu  Trp Tyr Trp Ser Gly  Arg His His Ile Ile  Gly Asp Asn 
    2750                 2755                 2760             


Pro Asn  Ser Ser Asp Tyr Pro  Ala Pro Arg Ala Val  Leu Thr Gly 
    2765                 2770                 2775             


His Asp  His Glu Val Val Cys  Val Ser Val Cys Ala  Glu Leu Gly 
    2780                 2785                 2790             


Leu Val  Ile Ser Gly Ala Lys  Glu Gly Pro Cys Leu  Val His Thr 
    2795                 2800                 2805             


Ile Thr  Gly Asp Leu Leu Arg  Ala Leu Glu Gly Pro  Glu Asn Cys 
    2810                 2815                 2820             


Leu Phe  Pro Arg Leu Ile Ser  Val Ser Ser Glu Gly  His Cys Ile 
    2825                 2830                 2835             


Ile Tyr  Tyr Glu Arg Gly Arg  Phe Ser Asn Phe Ser  Ile Asn Gly 
    2840                 2845                 2850             


Lys Leu  Leu Ala Gln Met Glu  Ile Asn Asp Ser Thr  Arg Ala Ile 
    2855                 2860                 2865             


Leu Leu  Ser Ser Asp Gly Gln  Asn Leu Val Thr Gly  Gly Asp Asn 
    2870                 2875                 2880             


Gly Val  Val Glu Val Trp Gln  Ala Cys Asp Phe Lys  Gln Leu Tyr 
    2885                 2890                 2895             


Ile Tyr  Pro Gly Cys Asp Ala  Gly Ile Arg Ala Met  Asp Leu Ser 
    2900                 2905                 2910             


His Asp  Gln Arg Thr Leu Ile  Thr Gly Met Ala Ser  Gly Ser Ile 
    2915                 2920                 2925             


Val Ala  Phe Asn Ile Asp Phe  Asn Arg Trp His Tyr  Glu His Gln 
    2930                 2935                 2940             


Asn Arg  Tyr 
    2945     


<210>  67
<211>  4675
<212>  DNA
<213>  Homo sapiens

<400>  67
agatgacaga cacttctcaa aagacagctt ttcttcctgg agaacagact ttttcagcag       60

gattttcctt tcagtgaaac ataatttgac ttgaaaggaa cccagggaaa agtgtccagg      120

tgtgagcatg agcgggtaga ggtgtgccct tgtttgcttc aggctgtctg cttttcgccc      180

ctgactgttt tttctgtttc tggccatgga ggaagagaaa gatgacagcc cacaggctga      240

cttctgcctg ggcaccgccc tgcactcttg gggactgtgg ttcacggagg aaggttcacc      300

gtccaccatg ctgacgggga ttgcagttgg agccctcctg gccctggcct tggttggtgt      360

cctcatcctt ttcatgttca gaaggcttag acaatttcga caagcacagc ccactcctca      420

gtaccggttc cggaagagag acaaagtgat gttttacggc cggaagatca tgaggaaggt      480

gaccacactc cccaacaccc ttgtggagaa cactgccctg ccccggcagc gggccaggaa      540

gaggaccaag gtgctgtctt tggccaagag gattctgcgt ttcaagaagg aatacccggc      600

cctgcagccc aaggagcccc cgccctccct gctggaggcc gacctcacgg agtttgacgt      660

gaagaattct cacctgccat cggaagttct gtacatgctg aaaaacgttc gggtcctggg      720

ccactttgag aagccgctgt tcctggagct ttgcaaacac atcgtctttg tgcagctgca      780

ggaaggggag cacgtcttcc agcccaggga gccggacccc agcatctgtg tggtgcagga      840

cgggcggctg gaggtctgca tccaggacac tgacggcacc gaggtggtgg tgaaagaggt      900

tctggcggga gacagcgtcc acagcctgct cagcatcctg gacatcatca ccggccatgc      960

tgcaccttac aaaacggtct ccgtccgcgc ggccatcccg tccaccatcc tccggcttcc     1020

agctgcggct tttcatggag tttttgagaa atatccggaa actctggtga gggtggtgca     1080

gatcatcatg gtgcggctgc agagggtgac ctttctggct ctgcacaact acctcggcct     1140

gaccacagag ctcttcaacg ctgagagcca ggccatccct ctcgtgtctg tagccagtgt     1200

ggctgccggg aaggccaaga agcaggtgtt ctatggcgaa gaagagcggc ttaaaaagcc     1260

accgcggctc caggagtcct gtgactcaga tcacgggggc ggccgcccgg cagctgctgg     1320

gcccctgctg aagaggagcc actccgtccc cgcgccttcc attcgcaaac agatcttgga     1380

ggagctggag aagcccgggg caggtgaccc tgacccttcg gccccacaag ggggcccagg     1440

cagtgccact tctgatctgg ggatggcatg tgaccgtgcc agggtcttcc tgcactcgga     1500

cgagcacccc gggagctccg tggccagcaa gtccaggaaa agcgtgatgg ttgcagagat     1560

accctccacg gtctcccagc actcagagag tcacacggat gagaccctgg ccagcaggaa     1620

gtcggatgcc atcttcagag ctgccaagaa ggacctgctc accctgatga agctggaaga     1680

ctcatctctg ttggatggcc gggtggcgct tctgcacgtt cctgcaggca cggtggtgtc     1740

aaggcaggga gaccaggacg ccagcatcct gttcgtggtc tcggggctgc tgcacgtgta     1800

ccagcggaag atcggcagcc aggaggacac ctgcttgttc ctcacgcgcc ccggggagat     1860

ggtgggccag ctggccgtgc tcaccgggga gcctctcatc ttcaccgtca aggccaacag     1920

ggactgcagc ttcctgtcca tctccaaggc ccacttctat gaaatcatgc ggaagcagcc     1980

gaccgtcgtc ctgggtgtgg cgcacactgt ggtgaagagg atgtcgtcct tcgtgcggca     2040

aatcgacttt gccctggact gggtggaggt ggaggccggg cgagcaatat acaggcaggg     2100

ggacaagtcc gactgcacgt acatcatgct cagcggccgg ctgcgctctg tgatccggaa     2160

ggatgatggg aagaagcgcc tggccgggga gtacggccga ggagacctcg tcggcgtggt     2220

ggagacactg acccaccagg cccgggcgac cacggtgcat gccgttcggg actcagaatt     2280

ggccaagctg ccggcaggag ccctcacgtc catcaagcgc aggtacccac aggtggtgac     2340

tcggctgatt catctcttgg gtgagaagat cctgggcagc ctccagcagg gacctgtgac     2400

aggccaccag cttgggctcc ccacggaggg cagcaagtgg gacttgggga acccggctgt     2460

caacctgtcc acggtggcag tgatgcccgt gtcagaggaa gtgcccctca ccgccttcgc     2520

cctggagctg gagcatgccc tcagcgccat cggcccgacc ctgctgctga ctagtgacaa     2580

cataaaacgg cgccttggct ccgctgccct ggacagtgtt cacgagtacc ggctgtccag     2640

ctggctgggg cagcaggagg acacccacag gatcgtgctc taccaggcag atggcacgct     2700

cacaccctgg acccagcgct gcgtgcgcca ggccgactgc atcctcatcg tgggcctggg     2760

tgaccaggag cccacagtgg gcgagctgga gcggatgctg gagagcacag ctgtgcgtgc     2820

ccagaagcag ctgatcctgc tgcacaggga ggagggcccg gcgccagcgc gcaccgtgga     2880

gtggctcaac atgcggagct ggtgctccgg ccacctgcac ctctgctgcc cgcgccgcgt     2940

cttctccagg aggagcctgc ccaagctggt ggagatgtac aagcatgtct tccagcggcc     3000

cccggaccga cactcagact tctcccgcct ggcgagggtg ctgacgggca acgccattgc     3060

cctggtgctt gggggagggg gagcaagagg ctgtgcccag gtgggcgttc tcaaggcctt     3120

ggcggagtgc ggcatccctg tggacatggt gggaggcacg tccatcgggg ccttcgtggg     3180

tgccctgtac tctgaggagc ggaactacag ccagatgcgg atccgggcca agcagtgggc     3240

cgagggcatg acgtccttga tgaaggccgc gctggacctc acctacccca tcacgtccat     3300

gttctccgga gccggcttca acagcagcat cttcagcgtc ttcaaggacc agcagatcga     3360

ggacctgtgg attccttatt tcgccatcac caccgacatc acagcctcgg ccatgcgggt     3420

ccacaccgac ggctccctgt ggtggtacgt gcgtgccagc atgtccctgt ccggttacat     3480

gccccctctc tgtgacccga aggacggaca cctgctgatg gacgggggct acatcaacaa     3540

cctcccagcg gatgtggccc ggtccatggg ggcaaaagtg gtgatcgcca ttgacgtggg     3600

cagccgagat gagacggacc tcaccaacta tggggatgcg ctgtctgggt ggtggctgct     3660

gtggaaacgc tggaacccct tggccacgaa agtcaaggtg ttgaacatgg cagagattca     3720

gacgcgcctg gcctacgtgt gttgcgtgcg gcagctggag gtggtgaaga gcagtgacta     3780

ctgcgagtac ctgcgccccc ccatcgacag ctacagcacc ctggacttcg gcaagttcaa     3840

cgagatctgc gaagtgggct accagcacgg gcgcacggtg tttgacatct ggggccgcag     3900

cggcgtgctg gagaagatgc tccgcgacca gcaggggccg agcaagaagc ccgcgagtgc     3960

ggtcctcacc tgtcccaacg cctccttcac ggaccttgcc gaaattgtgt ctcgcattga     4020

gcccgccaag cccgccatgg tggatgacga atctgactac cagacggagt acgaggagga     4080

gctgctggac gtccccaggg atgcatacgc agacttccag agcacctcag cccagcaggg     4140

ctcagacttg gaggacgagt cctcactgcg gcatcgacac cccagtctgg ctttcccaaa     4200

actgtctgag ggctcctctg accaggacgg gtagaggcct ctgctaaaga gcccggatgc     4260

agcgtcttcc gtgggactgt ccccaaggct gaggctcctg ccaagtccta ggggcctctg     4320

tacctgccct gctggaagcc ctgacttccc cggggcccca ggctgtgtta gggttctctg     4380

ggcctcttct ttgtaccagc agccctgcat acagggccct gtgagccccc ctgcagtcct     4440

gtgaggcccc tgaagctctg tgaggcccct gaagctctgt gaaccccctg cagccctgtg     4500

aggccccccg aagccctgtg aggccccccg aagccctgtg aaccacctgc tgccctgtga     4560

ggcccccaaa gccctgtgaa ctgcctgctg tcctgtgaac tgcctgctgc cctgtgaggt     4620

gtgggagccc tgatgctgcc gtgtgatgtt tcaataaagg tggatctcac tgttg          4675


<210>  68
<211>  1317
<212>  PRT
<213>  Homo sapiens

<400>  68

Met Glu Glu Glu Lys Asp Asp Ser Pro Gln Leu Thr Gly Ile Ala Val 
1               5                   10                  15      


Gly Ala Leu Leu Ala Leu Ala Leu Val Gly Val Leu Ile Leu Phe Met 
            20                  25                  30          


Phe Arg Arg Leu Arg Gln Phe Arg Gln Ala Gln Pro Thr Pro Gln Tyr 
        35                  40                  45              


Arg Phe Arg Lys Arg Asp Lys Val Met Phe Tyr Gly Arg Lys Ile Met 
    50                  55                  60                  


Arg Lys Val Thr Thr Leu Pro Asn Thr Leu Val Glu Asn Thr Ala Leu 
65                  70                  75                  80  


Pro Arg Gln Arg Ala Arg Lys Arg Thr Lys Val Leu Ser Leu Ala Lys 
                85                  90                  95      


Arg Ile Leu Arg Phe Lys Lys Glu Tyr Pro Ala Leu Gln Pro Lys Glu 
            100                 105                 110         


Pro Pro Pro Ser Leu Leu Glu Ala Asp Leu Thr Glu Phe Asp Val Lys 
        115                 120                 125             


Asn Ser His Leu Pro Ser Glu Val Leu Tyr Met Leu Lys Asn Val Arg 
    130                 135                 140                 


Val Leu Gly His Phe Glu Lys Pro Leu Phe Leu Glu Leu Cys Lys His 
145                 150                 155                 160 


Ile Val Phe Val Gln Leu Gln Glu Gly Glu His Val Phe Gln Pro Arg 
                165                 170                 175     


Glu Pro Asp Pro Ser Ile Cys Val Val Gln Asp Gly Arg Leu Glu Val 
            180                 185                 190         


Cys Ile Gln Asp Thr Asp Gly Thr Glu Val Val Val Lys Glu Val Leu 
        195                 200                 205             


Ala Gly Asp Ser Val His Ser Leu Leu Ser Ile Leu Asp Ile Ile Thr 
    210                 215                 220                 


Gly His Ala Ala Pro Tyr Lys Thr Val Ser Val Arg Ala Ala Ile Pro 
225                 230                 235                 240 


Ser Thr Ile Leu Arg Leu Pro Ala Ala Ala Phe His Gly Val Phe Glu 
                245                 250                 255     


Lys Tyr Pro Glu Thr Leu Val Arg Val Val Gln Ile Ile Met Val Arg 
            260                 265                 270         


Leu Gln Arg Val Thr Phe Leu Ala Leu His Asn Tyr Leu Gly Leu Thr 
        275                 280                 285             


Thr Glu Leu Phe Asn Ala Glu Ser Gln Ala Ile Pro Leu Val Ser Val 
    290                 295                 300                 


Ala Ser Val Ala Ala Gly Lys Ala Lys Lys Gln Val Phe Tyr Gly Glu 
305                 310                 315                 320 


Glu Glu Arg Leu Lys Lys Pro Pro Arg Leu Gln Glu Ser Cys Asp Ser 
                325                 330                 335     


Asp His Gly Gly Gly Arg Pro Ala Ala Ala Gly Pro Leu Leu Lys Arg 
            340                 345                 350         


Ser His Ser Val Pro Ala Pro Ser Ile Arg Lys Gln Ile Leu Glu Glu 
        355                 360                 365             


Leu Glu Lys Pro Gly Ala Gly Asp Pro Asp Pro Ser Ala Pro Gln Gly 
    370                 375                 380                 


Gly Pro Gly Ser Ala Thr Ser Asp Leu Gly Met Ala Cys Asp Arg Ala 
385                 390                 395                 400 


Arg Val Phe Leu His Ser Asp Glu His Pro Gly Ser Ser Val Ala Ser 
                405                 410                 415     


Lys Ser Arg Lys Ser Val Met Val Ala Glu Ile Pro Ser Thr Val Ser 
            420                 425                 430         


Gln His Ser Glu Ser His Thr Asp Glu Thr Leu Ala Ser Arg Lys Ser 
        435                 440                 445             


Asp Ala Ile Phe Arg Ala Ala Lys Lys Asp Leu Leu Thr Leu Met Lys 
    450                 455                 460                 


Leu Glu Asp Ser Ser Leu Leu Asp Gly Arg Val Ala Leu Leu His Val 
465                 470                 475                 480 


Pro Ala Gly Thr Val Val Ser Arg Gln Gly Asp Gln Asp Ala Ser Ile 
                485                 490                 495     


Leu Phe Val Val Ser Gly Leu Leu His Val Tyr Gln Arg Lys Ile Gly 
            500                 505                 510         


Ser Gln Glu Asp Thr Cys Leu Phe Leu Thr Arg Pro Gly Glu Met Val 
        515                 520                 525             


Gly Gln Leu Ala Val Leu Thr Gly Glu Pro Leu Ile Phe Thr Val Lys 
    530                 535                 540                 


Ala Asn Arg Asp Cys Ser Phe Leu Ser Ile Ser Lys Ala His Phe Tyr 
545                 550                 555                 560 


Glu Ile Met Arg Lys Gln Pro Thr Val Val Leu Gly Val Ala His Thr 
                565                 570                 575     


Val Val Lys Arg Met Ser Ser Phe Val Arg Gln Ile Asp Phe Ala Leu 
            580                 585                 590         


Asp Trp Val Glu Val Glu Ala Gly Arg Ala Ile Tyr Arg Gln Gly Asp 
        595                 600                 605             


Lys Ser Asp Cys Thr Tyr Ile Met Leu Ser Gly Arg Leu Arg Ser Val 
    610                 615                 620                 


Ile Arg Lys Asp Asp Gly Lys Lys Arg Leu Ala Gly Glu Tyr Gly Arg 
625                 630                 635                 640 


Gly Asp Leu Val Gly Val Val Glu Thr Leu Thr His Gln Ala Arg Ala 
                645                 650                 655     


Thr Thr Val His Ala Val Arg Asp Ser Glu Leu Ala Lys Leu Pro Ala 
            660                 665                 670         


Gly Ala Leu Thr Ser Ile Lys Arg Arg Tyr Pro Gln Val Val Thr Arg 
        675                 680                 685             


Leu Ile His Leu Leu Gly Glu Lys Ile Leu Gly Ser Leu Gln Gln Gly 
    690                 695                 700                 


Pro Val Thr Gly His Gln Leu Gly Leu Pro Thr Glu Gly Ser Lys Trp 
705                 710                 715                 720 


Asp Leu Gly Asn Pro Ala Val Asn Leu Ser Thr Val Ala Val Met Pro 
                725                 730                 735     


Val Ser Glu Glu Val Pro Leu Thr Ala Phe Ala Leu Glu Leu Glu His 
            740                 745                 750         


Ala Leu Ser Ala Ile Gly Pro Thr Leu Leu Leu Thr Ser Asp Asn Ile 
        755                 760                 765             


Lys Arg Arg Leu Gly Ser Ala Ala Leu Asp Ser Val His Glu Tyr Arg 
    770                 775                 780                 


Leu Ser Ser Trp Leu Gly Gln Gln Glu Asp Thr His Arg Ile Val Leu 
785                 790                 795                 800 


Tyr Gln Ala Asp Gly Thr Leu Thr Pro Trp Thr Gln Arg Cys Val Arg 
                805                 810                 815     


Gln Ala Asp Cys Ile Leu Ile Val Gly Leu Gly Asp Gln Glu Pro Thr 
            820                 825                 830         


Val Gly Glu Leu Glu Arg Met Leu Glu Ser Thr Ala Val Arg Ala Gln 
        835                 840                 845             


Lys Gln Leu Ile Leu Leu His Arg Glu Glu Gly Pro Ala Pro Ala Arg 
    850                 855                 860                 


Thr Val Glu Trp Leu Asn Met Arg Ser Trp Cys Ser Gly His Leu His 
865                 870                 875                 880 


Leu Cys Cys Pro Arg Arg Val Phe Ser Arg Arg Ser Leu Pro Lys Leu 
                885                 890                 895     


Val Glu Met Tyr Lys His Val Phe Gln Arg Pro Pro Asp Arg His Ser 
            900                 905                 910         


Asp Phe Ser Arg Leu Ala Arg Val Leu Thr Gly Asn Ala Ile Ala Leu 
        915                 920                 925             


Val Leu Gly Gly Gly Gly Ala Arg Gly Cys Ala Gln Val Gly Val Leu 
    930                 935                 940                 


Lys Ala Leu Ala Glu Cys Gly Ile Pro Val Asp Met Val Gly Gly Thr 
945                 950                 955                 960 


Ser Ile Gly Ala Phe Val Gly Ala Leu Tyr Ser Glu Glu Arg Asn Tyr 
                965                 970                 975     


Ser Gln Met Arg Ile Arg Ala Lys Gln Trp Ala Glu Gly Met Thr Ser 
            980                 985                 990         


Leu Met Lys Ala Ala Leu Asp Leu  Thr Tyr Pro Ile Thr  Ser Met Phe 
        995                 1000                 1005             


Ser Gly  Ala Gly Phe Asn Ser  Ser Ile Phe Ser Val  Phe Lys Asp 
    1010                 1015                 1020             


Gln Gln  Ile Glu Asp Leu Trp  Ile Pro Tyr Phe Ala  Ile Thr Thr 
    1025                 1030                 1035             


Asp Ile  Thr Ala Ser Ala Met  Arg Val His Thr Asp  Gly Ser Leu 
    1040                 1045                 1050             


Trp Trp  Tyr Val Arg Ala Ser  Met Ser Leu Ser Gly  Tyr Met Pro 
    1055                 1060                 1065             


Pro Leu  Cys Asp Pro Lys Asp  Gly His Leu Leu Met  Asp Gly Gly 
    1070                 1075                 1080             


Tyr Ile  Asn Asn Leu Pro Ala  Asp Val Ala Arg Ser  Met Gly Ala 
    1085                 1090                 1095             


Lys Val  Val Ile Ala Ile Asp  Val Gly Ser Arg Asp  Glu Thr Asp 
    1100                 1105                 1110             


Leu Thr  Asn Tyr Gly Asp Ala  Leu Ser Gly Trp Trp  Leu Leu Trp 
    1115                 1120                 1125             


Lys Arg  Trp Asn Pro Leu Ala  Thr Lys Val Lys Val  Leu Asn Met 
    1130                 1135                 1140             


Ala Glu  Ile Gln Thr Arg Leu  Ala Tyr Val Cys Cys  Val Arg Gln 
    1145                 1150                 1155             


Leu Glu  Val Val Lys Ser Ser  Asp Tyr Cys Glu Tyr  Leu Arg Pro 
    1160                 1165                 1170             


Pro Ile  Asp Ser Tyr Ser Thr  Leu Asp Phe Gly Lys  Phe Asn Glu 
    1175                 1180                 1185             


Ile Cys  Glu Val Gly Tyr Gln  His Gly Arg Thr Val  Phe Asp Ile 
    1190                 1195                 1200             


Trp Gly  Arg Ser Gly Val Leu  Glu Lys Met Leu Arg  Asp Gln Gln 
    1205                 1210                 1215             


Gly Pro  Ser Lys Lys Pro Ala  Ser Ala Val Leu Thr  Cys Pro Asn 
    1220                 1225                 1230             


Ala Ser  Phe Thr Asp Leu Ala  Glu Ile Val Ser Arg  Ile Glu Pro 
    1235                 1240                 1245             


Ala Lys  Pro Ala Met Val Asp  Asp Glu Ser Asp Tyr  Gln Thr Glu 
    1250                 1255                 1260             


Tyr Glu  Glu Glu Leu Leu Asp  Val Pro Arg Asp Ala  Tyr Ala Asp 
    1265                 1270                 1275             


Phe Gln  Ser Thr Ser Ala Gln  Gln Gly Ser Asp Leu  Glu Asp Glu 
    1280                 1285                 1290             


Ser Ser  Leu Arg His Arg His  Pro Ser Leu Ala Phe  Pro Lys Leu 
    1295                 1300                 1305             


Ser Glu  Gly Ser Ser Asp Gln  Asp Gly 
    1310                 1315         


<210>  69
<211>  982
<212>  DNA
<213>  Homo sapiens

<400>  69
acagcccacc agtgaccacg aaggctgtgc tgcttgccct gttgatggca ggcttggccc       60

tgcagccagg cactgccctg ctgtgctact cctgcaaagc ccaggtgagc aacgaggact      120

gcctgcaggt ggagaactgc acccagctgg gggagcagtg ctggaccgcg cgcatccgcg      180

cagttggcct cctgaccgtc atcagcaaag gctgcagctt gaactgcgtg gatgactcac      240

aggactacta cgtgggcaag aagaacatca cgtgctgtga caccgacttg tgcaacgcca      300

gcggggccca tgccctgcag ccggctgctg ccatccttgc gctgctccct gcactcggcc      360

tgctgctctg gggacccggc cagctctagg ctctgggggg ccccgctgca gcccacactg      420

ggtgtggtgc cccaggcctc tgtgccactc ctcacacacc cggcccagtg ggagcctgtc      480

ctggttcctg aggcacatcc taacgcaagt ctgaccatgt atgtctgcgc ccctgtcccc      540

caccctgacc ctcccatggc cctctccagg actcccaccc ggcagatcgg ctctattgac      600

acagatccgc ctgcagatgg cccctccaac cctctctgct gctgtttcca tggcccagca      660

ttctccaccc ttaaccctgt gctcaggcac ctcttccccc aggaagcctt ccctgcccac      720

cccatctatg acttgagcca ggtctggtcc gtggtgtccc ccgcacccag caggggacag      780

gcactcagga gggcccggta aaggctgaga tgaagtggac tgagtagaac tggaggacag      840

gagtcgacgt gagttcctgg gagtctccag agatggggcc tggaggcctg gaggaagggg      900

ccaggcctca cattcgtggg gctccctgaa tggcagcctc agcacagcgt aggcccttaa      960

taaacacctg ttggataagc ca                                               982


<210>  70
<211>  114
<212>  PRT
<213>  Homo sapiens

<400>  70

Met Ala Gly Leu Ala Leu Gln Pro Gly Thr Ala Leu Leu Cys Tyr Ser 
1               5                   10                  15      


Cys Lys Ala Gln Val Ser Asn Glu Asp Cys Leu Gln Val Glu Asn Cys 
            20                  25                  30          


Thr Gln Leu Gly Glu Gln Cys Trp Thr Ala Arg Ile Arg Ala Val Gly 
        35                  40                  45              


Leu Leu Thr Val Ile Ser Lys Gly Cys Ser Leu Asn Cys Val Asp Asp 
    50                  55                  60                  


Ser Gln Asp Tyr Tyr Val Gly Lys Lys Asn Ile Thr Cys Cys Asp Thr 
65                  70                  75                  80  


Asp Leu Cys Asn Ala Ser Gly Ala His Ala Leu Gln Pro Ala Ala Ala 
                85                  90                  95      


Ile Leu Ala Leu Leu Pro Ala Leu Gly Leu Leu Leu Trp Gly Pro Gly 
            100                 105                 110         


Gln Leu 
        


<210>  71
<211>  7273
<212>  DNA
<213>  Homo sapiens

<400>  71
aaccctgcct gaactttcct gtaaacagcc actgacagac tgcatccctg ctgggtggat       60

cctgcgactc ctagagggaa tggcacttct tgtttttaat tagcaaggtg aaaggtgaat      120

taaaactagc agtttggcaa gtcagtgcaa gaggctgact tctgagaggc ttccaggagc      180

ccgaagagag gacctccacg ggagaaggga gtgcgtgtgc tcggttttgt ttttttctct      240

cttttttttt tttttttctg aatgaacagc tttgcccaag tgactgaaaa atacagcttc      300

ttcctgaatc taccggcgta gttgctgaag agcgctctag acaggacatg gctctgaaga      360

ctcactcttt ggaatgtcct cttgctcccg gcttataaac aactgtcccg aggaaagaaa      420

ggttttacat agccaaatac agcctgacaa atggcacttc ggaactgtgc tttctgatga      480

caacgcgttc gatttctgac aaagcctctc gcacgctgcc cctggaggga agtcctaagt      540

aaaactcaga ccctccttaa agtgaggagc gagggcttgg acggtgaaca cggcagcatg      600

gcatccgcgg ggcacattat caccttgctc ctgtggggtt acttactgga gctttggaca      660

ggaggtcata cagctgatac tacccacccc cggttacgcc tgtcacataa agagctcttg      720

aatctgaaca gaacatcaat atttcatagc ccttttggat ttcttgatct ccatacaatg      780

ctgctggatg aatatcaaga gaggctcttc gtgggaggca gggaccttgt atattccctc      840

agcttggaga gaatcagtga cggctataaa gagatacact ggccgagtac agctctaaaa      900

atggaagaat gcataatgaa gggaaaagat gcgggtgaat gtgcaaatta tgttcgggtt      960

ttgcatcact ataacaggac acaccttctg acctgtggta ctggagcttt tgatccagtt     1020

tgtgccttca tcagagttgg atatcatttg gaggatcctc tgtttcacct ggaatcaccc     1080

agatctgaga gaggaagggg cagatgtcct tttgacccca gctcctcctt catctccact     1140

ttaattggta gtgaattgtt tgctggactc tacagtgact actggagcag agacgctgcg     1200

atcttccgca gcatggggcg actggcccat atccgcactg agcatgacga tgagcgtctg     1260

ttgaaagaac caaaatttgt aggttcatac atgattcctg acaatgaaga cagagatgac     1320

aacaaagtat atttcttttt tactgagaag gcactggagg cagaaaacaa tgctcacgca     1380

atttacacca gggtcgggcg actctgtgtg aatgatgtag gagggcagag aatactggtg     1440

aataagtgga gcactttcct aaaagcgaga ctcgtttgct cagtaccagg aatgaatgga     1500

attgacacat attttgatga attagaggac gtttttttgc tacctaccag agatcataag     1560

aatccagtga tatttggact ctttaacact accagtaata tttttcgagg gcatgctata     1620

tgtgtctatc acatgtctag cattcgggca gccttcaacg gaccatatgc acataaggaa     1680

ggacctgaat accactggtc agtctatgaa ggaaaagtcc cttatccaag gcctggttct     1740

tgtgccagca aagtaaatgg agggagatac ggaaccacca aggactatcc tgatgatgcc     1800

atccgatttg caagaagtca tccactaatg taccaggcca taaaacctgc ccataaaaaa     1860

ccaatattgg taaaaacaga tggaaaatat aacctgaaac aaatagcagt agatcgagtg     1920

gaagctgagg atggccaata tgacgtcttg tttattggga cagataatgg aattgtgctg     1980

aaagtaatca caatttacaa ccaagaaatg gaatcaatgg aagaagtaat tctagaagaa     2040

cttcagatat tcaaggatcc agttcctatt atttctatgg agatttcttc aaagcggcaa     2100

cagctgtata ttggatctgc ttctgctgtg gctcaagtca gattccatca ctgtgacatg     2160

tatggaagtg cttgtgctga ctgctgcctg gctcgagacc cttactgtgc ctgggatggc     2220

atatcctgct cccggtatta cccaacaggc acacatgcaa aaaggcgttt ccggagacaa     2280

gatgttcgac atggaaatgc agctcagcag tgctttggac aacagtttgt tggggatgct     2340

ttggataaga ctgaagaaca tctggcttat ggcatagaga acaacagtac tttgctggaa     2400

tgtaccccac gatctttaca agcgaaagtt atctggtttg tacagaaagg acgtgagaca     2460

agaaaagagg aggtgaagac agatgacaga gtggttaaga tggaccttgg tttactcttc     2520

ctaaggttac acaaatcaga tgctgggacc tatttttgcc agacagtaga gcatagcttt     2580

gtccatacgg tccgtaaaat caccttggag gtagtggaag aggagaaagt cgaggatatg     2640

tttaacaagg acgatgagga ggacaggcat cacaggatgc cttgtcctgc tcagagtagc     2700

atctcgcagg gagcaaaacc atggtacaag gaattcttgc agctgatcgg ttatagcaac     2760

ttccagagag tggaagaata ctgcgagaaa gtatggtgca cagatagaaa gaggaaaaag     2820

cttaaaatgt caccctccaa gtggaagtat gccaaccctc aggaaaagaa gctccgttcc     2880

aaacctgagc attaccgcct gcccaggcac acgctggact cctgatgggg tgagactatc     2940

tactgtcttt tgaagaattt atatttggaa agtaaaaaag taaaaaaata aatcatccaa     3000

cttctttgca ttacttaaaa gagatttctg taatacagga atgactatga aggtgttata     3060

ataaattatt ctacatactc atttgactgg ataaacttta cataaaatta actaattttt     3120

taaataaatg cattgcttaa tggtttctca ttatgtttat caaaaaacaa ctgtagctgt     3180

tattttcagt acttggctgc ttttctgtga aaattattat tttacttttg gaagacaaga     3240

ttattagaat attgaagaaa aattggagac ttataatcat ggtaaatata aaactaaata     3300

tgttttaata tttctgaatt tttcttttcc atcacaatgt aagatatgca gaatacaaga     3360

tactttggca ttctcatgtg aactttctgt actctttaag gattatttta ttagtgttgt     3420

ttaagccatg agtgttaagt agcaggtgtg ttgtgagtgc tgtaacccat gaaaggaaaa     3480

atgtcattct gaggcttgtg cccttcgtaa aatattcatt aaagtacatt cacactattt     3540

ttgctttata acacagtctt taattttcac tcactgtgga aataaaaact aaggtaactt     3600

ctcagaaaga tatcaaatct cagaaagaat gtcaaatcag atgaagttat agttaggatt     3660

ctaactactg taaaagattt ttgcttccct cttgtggtaa aaaaaattat attctcacac     3720

atttcttttt tctctacaga cggatatctg tttaggaaag atttgaaagc agattatcag     3780

taggtacatg gatacatcaa gttcatttgc agaaacaaat aactgaaata aaaaacatgt     3840

taatccttgt atcatacttt aatatgaaag tattgtttat agataattta tctcacaagt     3900

caaaaatgaa gattttgcag cactgaaaat ctattaaagc tccaaatttt aagtttctaa     3960

ataatcttcg ctgaaatcta aaatatacta taacaaccgt gttttatttg tgaaaaaaat     4020

attaaagtga tttgctctca aatatcaaat tttcttctct cttttatatt aagagacaga     4080

aaattgtttc atgagttcac ttaactactg agatattcag agcattttta cctctctctt     4140

aaatgttata aaaaacaatt gtatttttaa gaatgtttat ttatcaaagt ctttccttct     4200

tctattaaat atttagcaat tacctttcta aaatatgaaa ttttgtaaga tgttttcacc     4260

taaataaaaa ttgaaagcaa gtggattaca caggagaacc attatgaaca tttatttaga     4320

tattaatctt aaacagtgtt tatttcagtt ttcaaagtta gcttataggt tatacattta     4380

agttaaagtg ctcataatca cttgcaattt cattgtaaaa tgaacaaata cataaatatt     4440

ttaagaaaaa tttaagttta ttcagataag tcaccatgct tcaaaagatc taagaaatgc     4500

aaatatactg aaaattgaca tcctctgaaa attccacttg ctatttaccc aagaatccac     4560

tggaggtcat tactgccatt aaataataac tgaaaagact atgtagtgaa atgtattttt     4620

aaaaactata ttcagtaaaa gcctgctcaa tttggagaaa tagaaccaca aacacagatc     4680

acaggggcct tacaaagttt atgtctgaac aaataagtca attaagtaca ctttattgaa     4740

aattgccttc cattaacaca caagaaagaa agcaggattt tctcctgtat ctgaatttta     4800

aaattaaaaa ggcagataag acataaatag ttatcatttt aattgcaata acacagacaa     4860

gtagttaatg atgataacaa tggtgtaact tgtaaactaa atatttggta actgaagcaa     4920

taggcagagg aaaatagctt ttctatgaca caagtcataa gaagtccata tactgaagag     4980

cgtttgatta aaataaagtg actattaacc agaaaagaaa cattttacat aaaatgctaa     5040

aatttattat aggaaaataa atcaaaccca aagaaagttt attcaatgct aatttgaaag     5100

aaaattgata agaaaacttt gagggcccaa gtccacaatt tggtgagacc actaaatttt     5160

acatataatt atacacacac atatgtacat atatatgtat ataatcttgc ttcccgcctg     5220

tttatggcag tactgaagag aaatgggaaa gaagagggag ggagagagaa agacgaaggg     5280

agagagaaag cagtttccaa ggatatgttt catgtcccac cattttctca gtttctccct     5340

ctctctccca acacacacac acacacaccc ctcacatact ataaaataaa tcttcactgc     5400

cctatcaaaa tacaaataaa tcaatctatg ctgttctgtc cttcttgaga atctaaaaca     5460

taccacaaaa atacatcccc agtcttttgt tctgtctgag gttagaatta attcaaattc     5520

agaatctgtt gtgagaaatg cccaggcttt aaaaattaaa aatggatgga tcttctctga     5580

actcagggag ggcacatact tagataccta caagacttgg aggaattaag agttcaccct     5640

tcatctcacc aaattttccc catttttctc tttcttgtag aaggagagaa accatgctct     5700

ctagcaacat tgagcaaaaa tcataaccac tcatctaatt tctaagaggc acctccatcg     5760

agggccggtc tcctgcttct ttagacctct tctatctttg ttacaggaga ggacctgtgg     5820

atagacttag ttttgacata aaacaatgcc cattcacctc ctccttcagc acaacgtcac     5880

ccattgggca agagatccag atttgttaac aaaaaagatt ttacttcgtg attccacgtc     5940

tataattcta tattgctaat tttttctttt gtgtgaatta ctgaatattt cagagcaaag     6000

ctatcaactt ggagaaacag ggattaaaaa taaggataaa cactaataag agctctagaa     6060

aaaagggaac agaaagtctg cctgtttagt aagtggcaat tccatacata ttttagagtt     6120

ttttctatct aaaattagtt aaatacttag aatgtttgta atgagtgttc gatatttgct     6180

ataggtttta gggttttgta aatcttcata gtaattataa acatttgtaa aatttgtaaa     6240

atactataag tcattttgag tgttggtgtt aagcatgaaa caaacagcag ctgttgtcct     6300

taaaaatgaa ttgacctggc cgggcgcggt ggctcacgcc tgtaatccca gcactttggg     6360

aggccgaggc gggtggatca tgaggtcagg agatcgagac catcctggct aacaaggtga     6420

aaccccgtct ctactaaaaa tacaaaaaat tagccgggcg cggtggcggg cgcctgtagt     6480

cccagctact tgggaggctg aggcaggaga atggcgtgaa cccgggaagc ggagcttgca     6540

gtgagccgag attgcgccac tgcagtccgc agtccggcct gggcgacaga gcgagactcc     6600

gtctcaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa tgaattgacc     6660

tgtgacacct gtagcctaat aaacatatta agaaaagtac ttagtattgt atagatattt     6720

ggattccaag agaaaatgca acatttataa taagaagtcc atactctttt tcttacagca     6780

gagcgtcaca ctgagttcca ttttaaaaaa ggactcattt ttcaggccaa caactgttgc     6840

atttgaatca gatataaata atagattttc cacaaacact cagctgattg tagcagtgtt     6900

atttaagctg gtatgtttat tttttttttc ttggaaggat agctttatat tttggctttc     6960

attataaatt gtgttctgct tgtgtttaaa tggcttactt ataagctaga gcactatatg     7020

ggagtgttct tctctgtatg gtatcctttt atttgcttgg ctgggttcat aacagtgtgt     7080

gccatattct ttcttttcac tgattctaag ccatgagact tattagcatc tggtggcaag     7140

ctgcagggac cattaacagt gtgtctcttt gactacaacg tggatctgcc actacgcgct     7200

atgtaccatt atgtacaatc tctatttggc tcaacttcga tgaaaaagaa ataaatattt     7260

gctaaactct caa                                                        7273


<210>  72
<211>  775
<212>  PRT
<213>  Homo sapiens

<400>  72

Met Ala Ser Ala Gly His Ile Ile Thr Leu Leu Leu Trp Gly Tyr Leu 
1               5                   10                  15      


Leu Glu Leu Trp Thr Gly Gly His Thr Ala Asp Thr Thr His Pro Arg 
            20                  25                  30          


Leu Arg Leu Ser His Lys Glu Leu Leu Asn Leu Asn Arg Thr Ser Ile 
        35                  40                  45              


Phe His Ser Pro Phe Gly Phe Leu Asp Leu His Thr Met Leu Leu Asp 
    50                  55                  60                  


Glu Tyr Gln Glu Arg Leu Phe Val Gly Gly Arg Asp Leu Val Tyr Ser 
65                  70                  75                  80  


Leu Ser Leu Glu Arg Ile Ser Asp Gly Tyr Lys Glu Ile His Trp Pro 
                85                  90                  95      


Ser Thr Ala Leu Lys Met Glu Glu Cys Ile Met Lys Gly Lys Asp Ala 
            100                 105                 110         


Gly Glu Cys Ala Asn Tyr Val Arg Val Leu His His Tyr Asn Arg Thr 
        115                 120                 125             


His Leu Leu Thr Cys Gly Thr Gly Ala Phe Asp Pro Val Cys Ala Phe 
    130                 135                 140                 


Ile Arg Val Gly Tyr His Leu Glu Asp Pro Leu Phe His Leu Glu Ser 
145                 150                 155                 160 


Pro Arg Ser Glu Arg Gly Arg Gly Arg Cys Pro Phe Asp Pro Ser Ser 
                165                 170                 175     


Ser Phe Ile Ser Thr Leu Ile Gly Ser Glu Leu Phe Ala Gly Leu Tyr 
            180                 185                 190         


Ser Asp Tyr Trp Ser Arg Asp Ala Ala Ile Phe Arg Ser Met Gly Arg 
        195                 200                 205             


Leu Ala His Ile Arg Thr Glu His Asp Asp Glu Arg Leu Leu Lys Glu 
    210                 215                 220                 


Pro Lys Phe Val Gly Ser Tyr Met Ile Pro Asp Asn Glu Asp Arg Asp 
225                 230                 235                 240 


Asp Asn Lys Val Tyr Phe Phe Phe Thr Glu Lys Ala Leu Glu Ala Glu 
                245                 250                 255     


Asn Asn Ala His Ala Ile Tyr Thr Arg Val Gly Arg Leu Cys Val Asn 
            260                 265                 270         


Asp Val Gly Gly Gln Arg Ile Leu Val Asn Lys Trp Ser Thr Phe Leu 
        275                 280                 285             


Lys Ala Arg Leu Val Cys Ser Val Pro Gly Met Asn Gly Ile Asp Thr 
    290                 295                 300                 


Tyr Phe Asp Glu Leu Glu Asp Val Phe Leu Leu Pro Thr Arg Asp His 
305                 310                 315                 320 


Lys Asn Pro Val Ile Phe Gly Leu Phe Asn Thr Thr Ser Asn Ile Phe 
                325                 330                 335     


Arg Gly His Ala Ile Cys Val Tyr His Met Ser Ser Ile Arg Ala Ala 
            340                 345                 350         


Phe Asn Gly Pro Tyr Ala His Lys Glu Gly Pro Glu Tyr His Trp Ser 
        355                 360                 365             


Val Tyr Glu Gly Lys Val Pro Tyr Pro Arg Pro Gly Ser Cys Ala Ser 
    370                 375                 380                 


Lys Val Asn Gly Gly Arg Tyr Gly Thr Thr Lys Asp Tyr Pro Asp Asp 
385                 390                 395                 400 


Ala Ile Arg Phe Ala Arg Ser His Pro Leu Met Tyr Gln Ala Ile Lys 
                405                 410                 415     


Pro Ala His Lys Lys Pro Ile Leu Val Lys Thr Asp Gly Lys Tyr Asn 
            420                 425                 430         


Leu Lys Gln Ile Ala Val Asp Arg Val Glu Ala Glu Asp Gly Gln Tyr 
        435                 440                 445             


Asp Val Leu Phe Ile Gly Thr Asp Asn Gly Ile Val Leu Lys Val Ile 
    450                 455                 460                 


Thr Ile Tyr Asn Gln Glu Met Glu Ser Met Glu Glu Val Ile Leu Glu 
465                 470                 475                 480 


Glu Leu Gln Ile Phe Lys Asp Pro Val Pro Ile Ile Ser Met Glu Ile 
                485                 490                 495     


Ser Ser Lys Arg Gln Gln Leu Tyr Ile Gly Ser Ala Ser Ala Val Ala 
            500                 505                 510         


Gln Val Arg Phe His His Cys Asp Met Tyr Gly Ser Ala Cys Ala Asp 
        515                 520                 525             


Cys Cys Leu Ala Arg Asp Pro Tyr Cys Ala Trp Asp Gly Ile Ser Cys 
    530                 535                 540                 


Ser Arg Tyr Tyr Pro Thr Gly Thr His Ala Lys Arg Arg Phe Arg Arg 
545                 550                 555                 560 


Gln Asp Val Arg His Gly Asn Ala Ala Gln Gln Cys Phe Gly Gln Gln 
                565                 570                 575     


Phe Val Gly Asp Ala Leu Asp Lys Thr Glu Glu His Leu Ala Tyr Gly 
            580                 585                 590         


Ile Glu Asn Asn Ser Thr Leu Leu Glu Cys Thr Pro Arg Ser Leu Gln 
        595                 600                 605             


Ala Lys Val Ile Trp Phe Val Gln Lys Gly Arg Glu Thr Arg Lys Glu 
    610                 615                 620                 


Glu Val Lys Thr Asp Asp Arg Val Val Lys Met Asp Leu Gly Leu Leu 
625                 630                 635                 640 


Phe Leu Arg Leu His Lys Ser Asp Ala Gly Thr Tyr Phe Cys Gln Thr 
                645                 650                 655     


Val Glu His Ser Phe Val His Thr Val Arg Lys Ile Thr Leu Glu Val 
            660                 665                 670         


Val Glu Glu Glu Lys Val Glu Asp Met Phe Asn Lys Asp Asp Glu Glu 
        675                 680                 685             


Asp Arg His His Arg Met Pro Cys Pro Ala Gln Ser Ser Ile Ser Gln 
    690                 695                 700                 


Gly Ala Lys Pro Trp Tyr Lys Glu Phe Leu Gln Leu Ile Gly Tyr Ser 
705                 710                 715                 720 


Asn Phe Gln Arg Val Glu Glu Tyr Cys Glu Lys Val Trp Cys Thr Asp 
                725                 730                 735     


Arg Lys Arg Lys Lys Leu Lys Met Ser Pro Ser Lys Trp Lys Tyr Ala 
            740                 745                 750         


Asn Pro Gln Glu Lys Lys Leu Arg Ser Lys Pro Glu His Tyr Arg Leu 
        755                 760                 765             


Pro Arg His Thr Leu Asp Ser 
    770                 775 


<210>  73
<211>  15580
<212>  DNA
<213>  Homo sapiens

<400>  73
atgctactcc ctgccctcct ctttgggatg gcgtgggccc tggctgacgg gcggtggtgt       60

gagtggacag agaccatccg tgtggaggag gaagtggcac cccgtcagga ggacctggta      120

ccctgtgcca gcctcgacca ttacagccgc ctgggctggc ggctggacct gccctggagt      180

ggccgctcgg ggcttacccg gtccccagcg cctgggctct gtcctatcta caaacctcca      240

gaaacccggc ctgccaagtg gaaccggaca gtgaggactt gttgcccagg ctgggggggc      300

gcccactgca ctgaggccct tgccaaagcc agtcctgaag gccactgctt tgccatgtgg      360

cagtgccagc tacaggcagg ctcagctaat gcctcagcag gaagcctgga ggagtgctgc      420

gcccggccct ggggacaaag ctggtgggat ggcagctccc aggcctgccg cagctgctcc      480

agccgacacc tgccaggcag tgcctcttct ccagccctcc tgcagcccct ggcaggggct      540

gtgggccagc tctggagcca gcaccagcgt ccctcggcca cctgtgcctc ctggtcgggc      600

ttccactacc gcacctttga tggccgccac tatcacttcc tgggccgctg cacctacctg      660

ctggcgggtg ctgcggactc cacctgggct gtccacctaa cacccgggga ccgctgcccc      720

cagcctggac actgtcagcg ggtgactatg ggacccgagg aggtgctgat ccaggctgga      780

aatgtgtctg tgaaggggca gctggtacct gaagggcagt cttggctgct ccacgggctg      840

agcctgcaat ggctggggga ctggctggtg ctgtcaggag gcctgggggt cgtggtgcgg      900

ctggacagga ctggctccat ctccatctct gtggaccacg agctctgggg acagacacaa      960

ggcctctgtg ggctctacaa tggctggcca gaggatgact tcatggagcc aggcggaggg     1020

ctggccatgt tagcagccac ctttggaaat tcctggaggc tccctggctc ggagtctggg     1080

tgtctggatg cagtggaggt ggcccagggc tgtgaccccc tggggctcat agacgcagat     1140

gtagaacctg gccacctgcg ggctgaagcc caggacgtgt gccatcagct gctggaaggt     1200

ccattcgggc agtgccatgc ccaggtttcc cctgctgagt accacgaggc ctgtctcttt     1260

gcctactgcg caggggccat ggcaggcagt gggcaagagg ggcggcagca ggctgtttgt     1320

gccacctttg ccagctatgt ccaggcctgt gccaggcggc acatccacat tcgctggagg     1380

aagcctggct tctgcgagcg cctgtgcccc gggggccagc tctactccga ctgcgtctcc     1440

ctctgcccac ccagctgcga ggcggtgggt cagggagagg aggagtcctg cagggaagag     1500

tgtgtgagtg gctgtgagtg cccgcgaggc ctcttctgga atggcaccct ctgtgtgcct     1560

gctgcccact gcccctgcta ctactgccgc cagcgctatg tacccggtga caccgtgcgc     1620

cagctgtgta acccctgcgt gtgcagggat ggccgctggc actgtgccca ggcactgtgc     1680

cccgccgagt gtgcagtggg tggggacggg cactacctca ccttcgatgg gcggagctac     1740

tccttctggg gtggtcaagg ttgccgctac agcctggtgc aggactatgt gaagggacag     1800

ctactgatcc tactggagca tggggcctgc gacgctggga gctgcctgca cgccatctcc     1860

gtctccctgg aggacaccca catccagctc agggactcag gagctgtgct ggtcaatggg     1920

caggatgtgg gcttgccctg gattggcgct gagggcctca gtgtgcgccg agcttcctct     1980

gcctttctgc tgctgcgctg gcctggggcc caggtgctct ggggactgtc tgaccctgta     2040

gcctacatca ccctggaccc ccgccatgcc caccaggtgc agggtctgtg tggcaccttc     2100

acccagaacc agcaggacga cttcctgaca ccagccggag atgtggaaac tagcattgct     2160

gcctttgcta gcaagttcca ggtggccggc aagggaagat gcccctctga ggacagtgcc     2220

ctgctgtctc cctgcaccac ccactcccag cgccacgcct tcgcagaggc ggcctgtgcc     2280

atcctgcaca gctctgtctt ccaggaatgc cacaggctgg tggacaaaga gccattctat     2340

ctgcgctgcc tggcagccgt gtgtggctgt gatcccggca gtgactgcct gtgcccggtg     2400

ctgtctgcct atgcgcgtcg ctgtgcccag gaaggtgcct cacctccctg gaggaaccag     2460

accctctgcc ctgttatgtg tcctggtggc caggagtacc gagagtgtgc cccagcatgc     2520

ggtcaacact gcgggaaacc agaggactgt ggagagctgg gcagctgtgt ggctggttgt     2580

aactgtcctc tggggctgct gtgggaccct gagggccagt gtgtgccccc cagcttgtgc     2640

ccctgccagc tcggagcccg tcgctatgcc cctggcagtg ccaccatgaa ggagtgcaac     2700

cgctgcatct gccaggaaag gggcctctgg aattgcacgg ctcgccactg cccttcacag     2760

gcattctgcc ccagggagct tgtctatgcc cctggtgcct gtctcctcac ctgtgacagc     2820

cccagcgcca atcactcctg ccctgcaggc agtactgatg gctgtgtctg tccaccaggc     2880

acggtgctgc tggacgagcg ctgtgtgcct cctgacctct gtccctgccg tcacagtggg     2940

cagtggtacc tgcccaacgc caccatccag gaagactgca acgtttgcgt gtgccggggc     3000

cggcagtggc actgcacagg ccagcggcgc agtgggcggt gccaggcatc aggcgccccc     3060

cactatgtga catttgacgg actggccttc acctatcctg gggcctgcga gtatctgctg     3120

gtgcgagagg ccagtggcct attcacagtc tctgcccaga acctgccctg tggggccagc     3180

ggtctcacct gcaccaaagc gctggccgtg cgtctggagg gcactgttgt gcacatgctc     3240

agaggccggg cagtgacggt gaatggggtg agcgtgacgc cccccaaggt ctacacaggc     3300

cctgggctga gcctgcgtcg tgctggcctc ttcctgctgc tctcgaccca cctgggcctc     3360

accctgctct gggatggagg gactcgggtc ctggtgcaac tgtcccctca gttccgtggt     3420

cgcgtggctg ggctgtgtgg tgactttgat ggagatgcca gtaatgatct gcggagccgc     3480

cagggcgtcc tggagcccac agctgaactg gctgcccact cctggcgcct cagccccctc     3540

tgccctgagc caggagacct gccacacccc tgcacgatga acacacaccg ggctggttgg     3600

gctcgggccc gctgtggggc gctgctgcag ccgctcttca cattatgcca cgcggaggtc     3660

cccccgcagc agcactatga gtggtgcctg tatgacgcct gcggctgcga ctcggggggt     3720

gactgtgagt gcctctgctc ggccattgcc acctatgcag atgagtgtgc ccggcatggg     3780

caccacgtgc gctggcgtag ccaggagctc tgctccctgc agtgtgaagg gggacaggta     3840

tatgaggcct gtggccccac gtgtcccccc acctgccatg agcagcatcc tgagcccggg     3900

tggcactgcc aggtggtggc ctgtgtggag ggctgcttct gccccgaggg gactctgctg     3960

cacggaggag cctgcttgga gccagcttcc tgcccctgtg agtggggccg caactccttc     4020

ccgccggggt ctgtgctgca aaaggactgc gggaactgca cgtgccagga aggtcaatgg     4080

cattgtgggg gtgacggtgg ccactgtgag gagcttgtgc ctgcctgtgc agagggagag     4140

gccctgtgcc aagagaatgg gcactgtgtg ccccatgggt ggctttgtga caaccaggac     4200

gactgtggcg atggctctga tgaggagggt tgtgccgccc caggctgtgg ggaggggcag     4260

atgacttgca gctccggcca ctgcctgccc ctggccctgc tctgtgaccg ccaggatgac     4320

tgtggagatg gcacggatga gccgagctat ccgtgccccc agggcttgct ggcctgtgcc     4380

gatggacgct gcctgccgcc ggccctgctc tgcgatgggc atcctgactg tctggatgcc     4440

gccgacgagg agtcctgtct ggggcaggtg acctgcgtcc ccggggaggt gtcctgtgtt     4500

gatggcacct gcctgggggc catccagctg tgtgacggag tctgggactg cccagatgga     4560

gccgatgagg ggccgggaca ctgcccccta ccttctctgc ccacacctcc tgccagcacc     4620

ttgcctggcc cctccccagg ctccctggac actgcgtcaa gtcccctggc cagcgccagc     4680

cctgcgccac cctgcggccc cttcgagttt cggtgcggca gcggcgagtg caccccgcgg     4740

ggctggcgct gcgaccagga ggaagactgc gccgacggca gcgacgagcg cggctgcgga     4800

gggccctgcg cgccgcacca cgcgccctgc gcccgcggcc ctcactgcgt gtcccccgag     4860

cagctgtgcg acggcgtgcg gcagtgtccc gacggctcgg acgagggccc cgacgcctgc     4920

ggggggctgc cagccctggg aggccccaac aggacagggc ttccctgccc agaatacacc     4980

tgccccaatg gcacctgcat aggcttccag ctggtgtgtg atgggcagcc tgactgtgga     5040

aggccagggc aggtgggccc ctccccagaa gagcagggtt gtggggcctg gggcccctgg     5100

agcccatggg ggccctgcag ccggacgtgt gggccctggg gccagggccg gagccgccgc     5160

tgctccccac tcggcctcct ggtgctacag aactgcccag ggcctgagca ccagtctcag     5220

gcctgcttca cggcagcctg cccagtggac ggtgaatgga gcacctggtc cccctggtct     5280

gtgtgctctg agccgtgcag gggcaccatg acgcggcaac ggcagtgcca ctcaccccag     5340

aatgggggcc gcacctgtgc tgcactgccc ggaggcctgc acagcacccg ccagaccaag     5400

ccttgccctc aggacggctg ccccaatgcc acttgctctg gggagctgat gttccagccc     5460

tgtgccccct gcccactgac ctgtgatgac atctctggcc aggtcacgtg cccacctgat     5520

tggccctgcg gcagcccggg ctgctggtgc ccagaagggc aggtgctggg cagcgagggg     5580

tggtgtgtgt ggccccggca gtgcccctgc ctggtggacg gtgcccgcta ctggcctggg     5640

caacgcatca aggccgactg ccagctctgc atctgccaag acggacggcc ccgacgctgc     5700

cgactcaacc cggactgcgc tgtggactgt ggctggtcct cctggtcacc ctgggccaag     5760

tgcctgggcc cctgtggaag ccagagcatc cagtggtcct tccggagctc caacaacccc     5820

cgcccctccg gccgaggtcg ccagtgccgt ggcatccacc gcaaggcacg caggtgccag     5880

acggagccct gtgaggggtg tgagcatcag ggccaggtcc accgtgtcgg ggaacgctgg     5940

catgggggcc cctgcagggt gtgccagtgt ctgcacaacc tcaccgcaca ctgctcaccc     6000

tactgcccgc tcggcagctg cccccagggc tgggtcttgg tggaggggac gggagaatca     6060

tgctgccact gtgccctacc tggagagaac cagacggtcc agcccatggc cactcctgcc     6120

gcagctccgg ctcccagtcc ccagatcaga ttccctttgg ccacttacat tctgcctccg     6180

tcaggagacc cctgctattc tcccctgggg ctggccggac tggctgaggg gagtctgcat     6240

gcatcgtccc agcagctgga acaccccacc caggctgccc tcctgggggc tcccacccag     6300

gggcccagcc ctcagggatg gcacgctgga ggggatgctt atgccaagtg gcacactcgg     6360

ccccattacc tgcagctgga cctgcttcag cctcggaacc tcactggcat cctagtgccg     6420

gagactggct cctccaacgc atatgccagc agcttctcac tccagttcag cagcaatggt     6480

ctacactggc atgactatcg tgacctcctg cctggcatct tgcccctgcc caagcttttc     6540

cccagaaact gggatgacct ggaccctgcc gtatggactt tcggccgcat ggtgcaggcg     6600

aggtttgtca gggtgtggcc ccacgatgtc caccacagcg atgtccccct gcaggtggag     6660

ctgctgggct gcgagccagg gtccccaccg gcacctctgt gcccaggggt tggactccgc     6720

tgtgccagtg gtgagtgtgt cctgagaggg ggcccttgtg acggtgttct ggactgcgag     6780

gatggctcgg atgaggaggg ctgtgtgttg ctgcctgagg gcactggcag attccattcc     6840

acagccaaga ccctggccct ctcctctgcc cagccggggc agctgctgca ctggcccagg     6900

gagggcctgg cagagactga gcactggccc cctgggcagg aatcccccac gtccccgaca     6960

gagacaaggc ccgtgagtcc tggcccagcc tccggggtgc ctcaccatgg ggaatctgtg     7020

cagatggtga ccaccacccc cataccccag atggaggcca ggaccctgcc accaggtatg     7080

gcagctgtga cggtggtgcc cccacaccct gtgactccag cgacccctgc tggccagagc     7140

gtcgccccag gacccttccc acctgtgcag tgtggccccg gccagacgcc ctgtgaggtg     7200

ctgggctgcg tggaacaggc gcaggtgtgt gatggcaggg aggattgcct cgacggctcc     7260

gacgagaggc actgcgccag gaatctactt atgtggctcc cttctctccc tgccttgtgg     7320

gcagcgagca ctgtgccctt catgatgcct accatggccc tgcctgggct tccagcctca     7380

agggccctct gttccccgag ccagctgagc tgtggcagcg gggagtgtct gtctgctgag     7440

cggcgctgtg acctgcggcc tgactgccag gatggctcgg acgaggatgg ctgtgtggac     7500

tgcgtgctgg ccccctggtc tgtctggagc agctgcagcc gcagctgtgg cctgggcctc     7560

accttccagc gccaggagct gctgcggcct cctctgccag ggggcagctg cccgcgtgac     7620

cggttccgaa gccagtcctg ctttgtgcag gcctgcccag tggctggggc atgggccatg     7680

tgggaggcct ggggaccctg cagcgtctcc tgcgggggtg gccatcagag tcgccagaga     7740

agctgtgtgg accccccacc caagaatggc ggtgccccct gccccggggc ctcccaagag     7800

agggcaccct gcggcttgca gccctgctca ggtggcacag actgcgagct gggccgtgtg     7860

tatgtgagtg ccgatctgtg ccagaagggg ctggtgcccc catgcccacc ctcctgcctg     7920

gatcccaagg ccaacagaag ctgcagtggg cattgtgtgg aaggatgccg ctgtcccccg     7980

gggctccttc tgcatgacac tcgctgcctg cccctctctg agtgcccctg cctggtgggc     8040

gaagagctga agtggccagg ggtgtccttc ctcctgggca actgcagcca atgcgtgtgt     8100

gagaaggggg agttgctgtg ccaaccaggg ggctgccccc tgccctgcgg ctggtcagcc     8160

tggtcctcct gggctccctg cgaccgctcc tgtggctctg gagtgagggc caggttcagg     8220

tctccctcca accctccggc agcctggggg ggtgccccgt gtgaaggtga ccggcaggaa     8280

ctgcagggct gccacacagt gtgtgggaca gaggtgttcg gctggacgcc ctggacttcc     8340

tggtcctcct gctcccaaag ctgccttgcc ccgggagggg gccctggctg gcgcagtcgt     8400

tcccgactct gccccagccc tggggattca tcctgcccag gagatgccac ccaggaggag     8460

ccctgcagcc cccctgtatg cccagtgcca agcatctggg gtctgtgggc tccctggtcc     8520

acttgctcag ccccctgtga tggaggcatc cagacacgtg ggcgcagctg ctccagcttg     8580

gctccagggg acaccacgtg cccaggaccc cacagtcaga ccagggactg caacacgcag     8640

ccctgcacag cccagtgccc agagaacatg ttgttccgct cagcagagca gtgtcaccag     8700

gaggggggtc cttgccctcg gctatgcctg acgcagggcc ccgggataga gtgtacgggc     8760

ttctgcgccc ccggctgcac ctgcccccct ggtcttttcc tgcacaatgc tagctgcctg     8820

ccccgcagcc agtgcccctg ccagctgcac gggcagctct atgcatcagg agcaatggct     8880

cgcctggact cctgcaacaa ctgcacctgt gtctctggta agatggcatg cacctcggag     8940

cgctgcccag tggcctgtgg ctggagtccc tggaccctgt ggagtctctg tagctgcagc     9000

tgcaacgtgg gcattcggcg ccgcttccgg gcaggcactg cacccccagc tgcctttggg     9060

ggtgctgagt gccaaggccc caccatggag gctgaattct gcagcctgcg gccatgtcca     9120

ggtcctggtg gggagtgggg cccttggtct ccgtgctccg tgccctgtgg tggtggctac     9180

aggaaccgca cccgaggcag cagccgcagc ctcatggagt tttccacctg tggcctgcag     9240

ccctgcgcag ggccagtgcc tggcatgtgt cccagggaca agcagtggct ggactgtgcc     9300

cagggccctg cctcttgtgc agagctcagc gccccaagag ggactaacca gacctgccac     9360

cctggctgcc actgcccctc tgggatgctt ctgctgaaca acgtgtgtgt gcccacccag     9420

gactgcccct gtgcccacga ggggcacctc taccccccgg gcagcactgt ggttcgtcca     9480

tgtgaaaact gctcctgtgt ctccgggctc atcgccaact gcagctcctg gccttgtgcg     9540

gagggtgagc ccacgtggtc accctggacc ccttggagcc agtgttcagc ctcctgtggc     9600

cctgcccggt gccatcggca ccggttctgt gccaggtccc ccagtgcagt gccatccacc     9660

gtggctccgc tgcccctgcc agccaccccc acacctctct gctcaggccc cgaggctgaa     9720

gaggagccat gtctcctgca ggggtgtgat cgagctgggg gatggggtcc atgggggccc     9780

tggtcccact gtagccggag ctgtggggga ggcctgcgga gccggacccg ggcctgtgac     9840

cagcccccac cccagggcct gggggattac tgcgaggggc cacgggcaca gggggaggtc     9900

tgccaggctc tgccctgccc agtgaccaac tgcactgcca ttgaaggggc cgagtatagc     9960

ccctgtggcc ctccgtgccc tcgctcctgt gatgacctag tgcactgcgt gtggcgctgc    10020

cagcctggct gctactgccc accaggccag gtactgagtt ccaacggggc catctgcgtg    10080

cagccgggtc actgcagctg cctggacctg ctgaccgggc agcggcacca tccgggtgct    10140

cggctggcaa ggcctgacgg ctgcaaccac tgcacctgcc tggaggggag gctgaactgc    10200

acagacctgc cctgcccagt gcccggaggc tggtgcccgt ggtcggagtg gacaatgtgc    10260

tcccagccct gcaggggcca gaccaggagc cgctccaggg cctgtgcctg ccccactcct    10320

cagcacggtg gtgccccgtg cactggagag gctggggagg caggggccca gcatcagagg    10380

gaggcctgcc ccagctacgc cacgtgccca gtggacggag cctggggccc atgggggcca    10440

tggtctccct gcgacatgtg cttggggcag tcccaccgga gccgggcgtg cagccggccc    10500

cccacccctg agggagggag gccctgccct gggaaccaca cgcagagtcg cccttgccag    10560

gaaaattcca cccagtgcac agactgcggg ggtggccaga gtctgcatcc ctgtgggcag    10620

ccctgccccc gctcctgcca ggacctgtcc cctgggagtg tgtgccagcc aggctctgtg    10680

ggctgccagc ccacttgtgg gtgccccctg ggccagctct cccaggacgg gctgtgcgtg    10740

cccccagccc actgccgctg ccagtaccag cctggagcca tggggatccc tgagaaccag    10800

agccgctcag cagggtctag gtttagctcc tgggagagcc tggaacccgg agaggtggtc    10860

actgggccat gtgacaactg cacctgtgtg gcaggcattc tgcaatgcca ggaggtgcct    10920

gactgcccgg accctggggt gtggagctct tggggccctt gggaagactg cagtgtttcg    10980

tgtgggggcg gggagcagct gcgctcccgg cgctgtgctc gtcctccctg cccagggcct    11040

gcccgccaga gccgcacatg cagcacacag gtctgcagag aggcaggctg cccggctggc    11100

cgcctgtacc gtgaatgcca gcccggcgag ggatgcccct tctcctgcgc ccacgtcacg    11160

cagcaggtgg gctgcttctc tgagggctgc gaggagggct gccactgccc cgagggcacc    11220

ttccagcacc gcctggcctg tgtgcaggag tgcccttgtg tgctgacagc ctggctgctg    11280

caggagctgg gagccaccat aggtgaccct ggtcagcccc tcgggcctgg agatgagctg    11340

gactcaggcc agacacttcg tacaagctgt ggcaactgct cgtgtgcaca cgggaagctg    11400

tcttgctccc tggacgactg cttcgaggcc gatggtggtt tcggtccctg gagcccgtgg    11460

ggcccgtgct cccgctcctg tggagggctg ggcacccgta cccgcagccg ccagtgtgtg    11520

ctcaccatgc ccaccctcag tggtcagggc tgccgtgggc cccgccagga cctcgagtgc    11580

cccagcccag actgccctgg ggctgaaggg tccacggtgg agccagtaac aggccttcca    11640

ggtggctggg gcccatggtc ctcctggtcc ccctgctcca gaagctgcac ggaccccgct    11700

cgccctgcat ggcgcagccg cacccgcctc tgcctggcta actgcaccat gggggaccca    11760

ttacaggagc gcccctgcaa cctgccctca tgcacagagc tgcccgtgtg ccctggccct    11820

ggctgtgggg ctgggaactg ttcctggacc tcctgggccc cgtgggaacc ttgctcccgc    11880

agctgcggag tgggccagca gcgccgcctg cgggcatacc gtccccctgg gcccggcggg    11940

cactggtgcc ccaacatcct tactgcctac caagagcgcc gcttctgcaa cctgcgagcc    12000

tgcccagtgc ccgggggctg gtcacgctgg agtccctggt cctggtgtga ccgcagctgt    12060

gggggaggcc aatccctgag aagccgcagc tgctcaagcc ccccatccaa gaacggggga    12120

gccccctgtg ctggggagcg gcaccaggcc cgcctctgca atcccatgcc ttgtgaggcc    12180

ggctgcccag caggcatgga ggtggtcacc tgtgccaacc gctgcccccg ccgctgctca    12240

gacctccagg agggaattgt gtgtcaggac gaccaggtct gccagaaggg ctgccgctgc    12300

ccaaaggggt ccctggagca ggatggtggc tgcgtgccaa ttgggcactg tgactgcacc    12360

gatgcccagg gccacagctg ggccccgggg agccagcacc aggatgcctg caacaactgc    12420

tcatgccaag ctgggcagct ctcctgcacg gctcagccct gcccgcctcc cacccactgt    12480

gcctggagcc actggtcggc ctggagtccc tgcagccact catgcgggcc cagagggcag    12540

cagagccgct tccggtcctc cacgtcgggc tcgtgggccc cagagtgtcg ggaggagcag    12600

tcccagagcc agccctgccc tcagccctcg tgcccacccc tgtgcctgca gggcactcgc    12660

tcccgcaccc tgggggacag ctggctgcag ggggagtgcc agcggtgctc ctgcaccccg    12720

gagggtgtga tctgcgaaga tacggagtgt gcagtgcctg aggcttggac gctgtggtcc    12780

tcctggtccg actgccctgt ctcctgtgga ggtggaaacc aggtccgaac ccgggcctgc    12840

agggccgcag cccctcacca caggagccca ccctgcctgg gccctgacac ccagaccagg    12900

cagcagcctt gcccagggct gctggaggcc tgctcctggg gcccgtgggg gccctgttcc    12960

cgcagctgcg gcccgggcct ggcctctcgc tctgggtcct gcccctgcct gatggccaag    13020

gccgacccca cctgcaacag caccttcctc cacctggaca cccagggctg ctactcaggg    13080

ccctgcccag aggagtgtgt gtggagcagc tggagcagct ggacgcgctg ctcttgccgg    13140

gtgctggtgc agcagcgcta ccgacaccag ggcccggcgt cccgaggggc cagggcaggc    13200

gccccctgca cgcggctgga tggccacttc cggccttgcc ttatcagcaa ctgctctgag    13260

gacagctgca cgcctccctt tgagttccat gcctgcggct ccccctgtgc tgggctctgt    13320

gccacacacc tgagccatca gctctgccag gacctgccac cctgccagcc gggctgctac    13380

tgccccaagg ggctgctgga gcaggctggg ggctgcattc ccccagagga gtgtaactgc    13440

tggcatacct cagcagcagg agccgggatg accctggccc ctggggaccg cctgcagctg    13500

ggctgtaagg agtgtgaatg ccggcgtggg gagctgcact gcaccagcca gggctgtcaa    13560

ggtcttctgc ctctgagtga gtggtccgag tggtcgccct gtgggccctg cctgccgccc    13620

agcgccctgg cccctgcctc caggactgcc ctagaggagc actggctccg agacccaact    13680

ggcctctccc ccaccttggc cccgctgctg gcttcagagc agcaccgcca ccggctctgt    13740

ctggatcctg cgacagggag gccctggact ggagcccctc acctctgcac cgcacccctc    13800

agccagcagc gcctctgccc tgaccctgga gcctgccctg actcatgcca gtggagtctg    13860

tgggggccat ggagcccctg ccaggtgccc tgcagtgggg ggttcaggct acgctggaga    13920

gaggcagagg ccctctgtgg aggaggctgc cgggagccat gggctcaaga aagctgcaac    13980

ggagggccct gcccagagtg cgaggcccaa gacactgtat tcaccctgga ctgtgccaac    14040

cagtgcccac acagctgtgc cgacctctgg gaccgcgttc agtgtctgca gggaccctgc    14100

cgcccaggct gccgctgtcc ccctggccag ctggtccagg atgggcgctg tgtgccgatc    14160

tcctcttgcc gctgtggcct ccccagtgcc aatgcctctt gggagctggc cccggcccag    14220

gcggtgcagc tggactgcca aaactgcacc tgtgtcaacg agtccctggt gtgcccacac    14280

caggagtgtc cagtccttgg gccttggtca gcctggagca gttgctcggc cccctgtggt    14340

gggggcacta tggagcgaca tcggacttgt gaggggggtc ctggggtggc accatgccag    14400

gcccaggaca cagagcaacg gcaggagtgt aacctgcagc cctgccctga gtgcccccct    14460

ggccaggtgc ttagtgcctg tgccacctca tgcccgtgcc tctgctggca tctgcagcct    14520

ggtgccatct gtgtgcagga gccctgccag cctggctgtg gctgccctgg agggcagctg    14580

ctgcacaatg gcacgtgtgt gcctcccact gcctgcccct gcacccagca ttctctgccc    14640

tggggcctca ccctgaccct ggaagagcag gcccaggagc tgcccccagg gactgtgctc    14700

acccggaact gcacccgctg tgtctgccac ggtggagcct tcagctgctc cctcgttgac    14760

tgtcaggtgc cccctgggga aacgtggcag caggtggccc cgggggagct ggggctctgc    14820

gagcagacgt gcctggagat gaacgccaca aagacccaga gtaactgcag ttcagctcga    14880

gcctcgggct gcgtgtgcca gcccgggcac ttccgcagcc aggcaggccc ctgcgtcccc    14940

gaagaccact gcgagtgctg gcaccttggg cgtccccacc tgcctggatc tgaatggcag    15000

gaggcctgtg agagctgcct ctgcctcagt gggaggcctg tctgcaccca gcactgctcc    15060

ccactcacct gtgctcaggg cgaggagatg gtgctggagc cagggagctg ctgtccctct    15120

tgccgcaggg aggctccgga ggagcagtcg ccctcctgcc agctcctcac ggagcttcga    15180

aacttcacca aagggacctg ttacctggac caggtagaag tgagctactg cagtgggtac    15240

tgcccatcca gcacccatgt catgccagag gagccatacc tgcagagcca gtgtgactgc    15300

tgcagctacc gtctagaccc ggagagccct gtgcggatcc tgaacctgcg ctgtctgggt    15360

ggccacacag agcccgtggt gctgccggtc atccacagct gccagtgcag ctcctgccag    15420

ggtggggact tctcaaagcg ctaacaggct ccgctgggtg agtccacagc tgtccctctt    15480

gtgatcatgg gactcagcag cactgaccac gtccttccac gctctctcac ctgcccccaa    15540

ctgggggccc atgacttggc attagcatgt tccaaataaa                          15580


<210>  74
<211>  5150
<212>  PRT
<213>  Homo sapiens

<400>  74

Met Leu Leu Pro Ala Leu Leu Phe Gly Met Ala Trp Ala Leu Ala Asp 
1               5                   10                  15      


Gly Arg Trp Cys Glu Trp Thr Glu Thr Ile Arg Val Glu Glu Glu Val 
            20                  25                  30          


Ala Pro Arg Gln Glu Asp Leu Val Pro Cys Ala Ser Leu Asp His Tyr 
        35                  40                  45              


Ser Arg Leu Gly Trp Arg Leu Asp Leu Pro Trp Ser Gly Arg Ser Gly 
    50                  55                  60                  


Leu Thr Arg Ser Pro Ala Pro Gly Leu Cys Pro Ile Tyr Lys Pro Pro 
65                  70                  75                  80  


Glu Thr Arg Pro Ala Lys Trp Asn Arg Thr Val Arg Thr Cys Cys Pro 
                85                  90                  95      


Gly Trp Gly Gly Ala His Cys Thr Glu Ala Leu Ala Lys Ala Ser Pro 
            100                 105                 110         


Glu Gly His Cys Phe Ala Met Trp Gln Cys Gln Leu Gln Ala Gly Ser 
        115                 120                 125             


Ala Asn Ala Ser Ala Gly Ser Leu Glu Glu Cys Cys Ala Arg Pro Trp 
    130                 135                 140                 


Gly Gln Ser Trp Trp Asp Gly Ser Ser Gln Ala Cys Arg Ser Cys Ser 
145                 150                 155                 160 


Ser Arg His Leu Pro Gly Ser Ala Ser Ser Pro Ala Leu Leu Gln Pro 
                165                 170                 175     


Leu Ala Gly Ala Val Gly Gln Leu Trp Ser Gln His Gln Arg Pro Ser 
            180                 185                 190         


Ala Thr Cys Ala Ser Trp Ser Gly Phe His Tyr Arg Thr Phe Asp Gly 
        195                 200                 205             


Arg His Tyr His Phe Leu Gly Arg Cys Thr Tyr Leu Leu Ala Gly Ala 
    210                 215                 220                 


Ala Asp Ser Thr Trp Ala Val His Leu Thr Pro Gly Asp Arg Cys Pro 
225                 230                 235                 240 


Gln Pro Gly His Cys Gln Arg Val Thr Met Gly Pro Glu Glu Val Leu 
                245                 250                 255     


Ile Gln Ala Gly Asn Val Ser Val Lys Gly Gln Leu Val Pro Glu Gly 
            260                 265                 270         


Gln Ser Trp Leu Leu His Gly Leu Ser Leu Gln Trp Leu Gly Asp Trp 
        275                 280                 285             


Leu Val Leu Ser Gly Gly Leu Gly Val Val Val Arg Leu Asp Arg Thr 
    290                 295                 300                 


Gly Ser Ile Ser Ile Ser Val Asp His Glu Leu Trp Gly Gln Thr Gln 
305                 310                 315                 320 


Gly Leu Cys Gly Leu Tyr Asn Gly Trp Pro Glu Asp Asp Phe Met Glu 
                325                 330                 335     


Pro Gly Gly Gly Leu Ala Met Leu Ala Ala Thr Phe Gly Asn Ser Trp 
            340                 345                 350         


Arg Leu Pro Gly Ser Glu Ser Gly Cys Leu Asp Ala Val Glu Val Ala 
        355                 360                 365             


Gln Gly Cys Asp Ser Pro Leu Gly Leu Ile Asp Ala Asp Val Glu Pro 
    370                 375                 380                 


Gly His Leu Arg Ala Glu Ala Gln Asp Val Cys His Gln Leu Leu Glu 
385                 390                 395                 400 


Gly Pro Phe Gly Gln Cys His Ala Gln Val Ser Pro Ala Glu Tyr His 
                405                 410                 415     


Glu Ala Cys Leu Phe Ala Tyr Cys Ala Gly Ala Met Ala Gly Ser Gly 
            420                 425                 430         


Gln Glu Gly Arg Gln Gln Ala Val Cys Ala Thr Phe Ala Ser Tyr Val 
        435                 440                 445             


Gln Ala Cys Ala Arg Arg His Ile His Ile Arg Trp Arg Lys Pro Gly 
    450                 455                 460                 


Phe Cys Glu Arg Leu Cys Pro Gly Gly Gln Leu Tyr Ser Asp Cys Val 
465                 470                 475                 480 


Ser Leu Cys Pro Pro Ser Cys Glu Ala Val Gly Gln Gly Glu Glu Glu 
                485                 490                 495     


Ser Cys Arg Glu Glu Cys Val Ser Gly Cys Glu Cys Pro Arg Gly Leu 
            500                 505                 510         


Phe Trp Asn Gly Thr Leu Cys Val Pro Ala Ala His Cys Pro Cys Tyr 
        515                 520                 525             


Tyr Cys Arg Gln Arg Tyr Val Pro Gly Asp Thr Val Arg Gln Leu Cys 
    530                 535                 540                 


Asn Pro Cys Val Cys Arg Asp Gly Arg Trp His Cys Ala Gln Ala Leu 
545                 550                 555                 560 


Cys Pro Ala Glu Cys Ala Val Gly Gly Asp Gly His Tyr Leu Thr Phe 
                565                 570                 575     


Asp Gly Arg Ser Tyr Ser Phe Trp Gly Gly Gln Gly Cys Arg Tyr Ser 
            580                 585                 590         


Leu Val Gln Asp Tyr Val Lys Gly Gln Leu Leu Ile Leu Leu Glu His 
        595                 600                 605             


Gly Ala Cys Asp Ala Gly Ser Cys Leu His Ala Ile Ser Val Ser Leu 
    610                 615                 620                 


Glu Asp Thr His Ile Gln Leu Arg Asp Ser Gly Ala Val Leu Val Asn 
625                 630                 635                 640 


Gly Gln Asp Val Gly Leu Pro Trp Ile Gly Ala Glu Gly Leu Ser Val 
                645                 650                 655     


Arg Arg Ala Ser Ser Ala Phe Leu Leu Leu Arg Trp Pro Gly Ala Gln 
            660                 665                 670         


Val Leu Trp Gly Leu Ser Asp Pro Val Ala Tyr Ile Thr Leu Asp Pro 
        675                 680                 685             


Arg His Ala His Gln Val Gln Gly Leu Cys Gly Thr Phe Thr Gln Asn 
    690                 695                 700                 


Gln Gln Asp Asp Phe Leu Thr Pro Ala Gly Asp Val Glu Thr Ser Ile 
705                 710                 715                 720 


Ala Ala Phe Ala Ser Lys Phe Gln Val Ala Gly Lys Gly Arg Cys Pro 
                725                 730                 735     


Ser Glu Asp Ser Ala Leu Leu Ser Pro Cys Thr Thr His Ser Gln Arg 
            740                 745                 750         


His Ala Phe Ala Glu Ala Ala Cys Ala Ile Leu His Ser Ser Val Phe 
        755                 760                 765             


Gln Glu Cys His Arg Leu Val Asp Lys Glu Pro Phe Tyr Leu Arg Cys 
    770                 775                 780                 


Leu Ala Ala Val Cys Gly Cys Asp Pro Gly Ser Asp Cys Leu Cys Pro 
785                 790                 795                 800 


Val Leu Ser Ala Tyr Ala Arg Arg Cys Ala Gln Glu Gly Ala Ser Pro 
                805                 810                 815     


Pro Trp Arg Asn Gln Thr Leu Cys Pro Val Met Cys Pro Gly Gly Gln 
            820                 825                 830         


Glu Tyr Arg Glu Cys Ala Pro Ala Cys Gly Gln His Cys Gly Lys Pro 
        835                 840                 845             


Glu Asp Cys Gly Glu Leu Gly Ser Cys Val Ala Gly Cys Asn Cys Pro 
    850                 855                 860                 


Leu Gly Leu Leu Trp Asp Pro Glu Gly Gln Cys Val Pro Pro Ser Leu 
865                 870                 875                 880 


Cys Pro Cys Gln Leu Gly Ala Arg Arg Tyr Ala Pro Gly Ser Ala Thr 
                885                 890                 895     


Met Lys Glu Cys Asn Arg Cys Ile Cys Gln Glu Arg Gly Leu Trp Asn 
            900                 905                 910         


Cys Thr Ala Arg His Cys Pro Ser Gln Ala Phe Cys Pro Arg Glu Leu 
        915                 920                 925             


Val Tyr Ala Pro Gly Ala Cys Leu Leu Thr Cys Asp Ser Pro Ser Ala 
    930                 935                 940                 


Asn His Ser Cys Pro Ala Gly Ser Thr Asp Gly Cys Val Cys Pro Pro 
945                 950                 955                 960 


Gly Thr Val Leu Leu Asp Glu Arg Cys Val Pro Pro Asp Leu Cys Pro 
                965                 970                 975     


Cys Arg His Ser Gly Gln Trp Tyr Leu Pro Asn Ala Thr Ile Gln Glu 
            980                 985                 990         


Asp Cys Asn Val Cys Val Cys Arg  Gly Arg Gln Trp His  Cys Thr Gly 
        995                 1000                 1005             


Gln Arg  Arg Ser Gly Arg Cys  Gln Ala Ser Gly Ala  Pro His Tyr 
    1010                 1015                 1020             


Val Thr  Phe Asp Gly Leu Ala  Phe Thr Tyr Pro Gly  Ala Cys Glu 
    1025                 1030                 1035             


Tyr Leu  Leu Val Arg Glu Ala  Ser Gly Leu Phe Thr  Val Ser Ala 
    1040                 1045                 1050             


Gln Asn  Leu Pro Cys Gly Ala  Ser Gly Leu Thr Cys  Thr Lys Ala 
    1055                 1060                 1065             


Leu Ala  Val Arg Leu Glu Gly  Thr Val Val His Met  Leu Arg Gly 
    1070                 1075                 1080             


Arg Ala  Val Thr Val Asn Gly  Val Ser Val Thr Pro  Pro Lys Val 
    1085                 1090                 1095             


Tyr Thr  Gly Pro Gly Leu Ser  Leu Arg Arg Ala Gly  Leu Phe Leu 
    1100                 1105                 1110             


Leu Leu  Ser Thr His Leu Gly  Leu Thr Leu Leu Trp  Asp Gly Gly 
    1115                 1120                 1125             


Thr Arg  Val Leu Val Gln Leu  Ser Pro Gln Phe Arg  Gly Arg Val 
    1130                 1135                 1140             


Ala Gly  Leu Cys Gly Asp Phe  Asp Gly Asp Ala Ser  Asn Asp Leu 
    1145                 1150                 1155             


Arg Ser  Arg Gln Gly Val Leu  Glu Pro Thr Ala Glu  Leu Ala Ala 
    1160                 1165                 1170             


His Ser  Trp Arg Leu Ser Pro  Leu Cys Pro Glu Pro  Gly Asp Leu 
    1175                 1180                 1185             


Pro His  Pro Cys Thr Met Asn  Thr His Arg Ala Gly  Trp Ala Arg 
    1190                 1195                 1200             


Ala Arg  Cys Gly Ala Leu Leu  Gln Pro Leu Phe Thr  Leu Cys His 
    1205                 1210                 1215             


Ala Glu  Val Pro Pro Gln Gln  His Tyr Glu Trp Cys  Leu Tyr Asp 
    1220                 1225                 1230             


Ala Cys  Gly Cys Asp Ser Gly  Gly Asp Cys Glu Cys  Leu Cys Ser 
    1235                 1240                 1245             


Ala Ile  Ala Thr Tyr Ala Asp  Glu Cys Ala Arg His  Gly His His 
    1250                 1255                 1260             


Val Arg  Trp Arg Ser Gln Glu  Leu Cys Ser Leu Gln  Cys Glu Gly 
    1265                 1270                 1275             


Gly Gln  Val Tyr Glu Ala Cys  Gly Pro Thr Cys Pro  Pro Thr Cys 
    1280                 1285                 1290             


His Glu  Gln His Pro Glu Pro  Gly Trp His Cys Gln  Val Val Ala 
    1295                 1300                 1305             


Cys Val  Glu Gly Cys Phe Cys  Pro Glu Gly Thr Leu  Leu His Gly 
    1310                 1315                 1320             


Gly Ala  Cys Leu Glu Pro Ala  Ser Cys Pro Cys Glu  Trp Gly Arg 
    1325                 1330                 1335             


Asn Ser  Phe Pro Pro Gly Ser  Val Leu Gln Lys Asp  Cys Gly Asn 
    1340                 1345                 1350             


Cys Thr  Cys Gln Glu Gly Gln  Trp His Cys Gly Gly  Asp Gly Gly 
    1355                 1360                 1365             


His Cys  Glu Glu Leu Val Pro  Ala Cys Ala Glu Gly  Glu Ala Leu 
    1370                 1375                 1380             


Cys Gln  Glu Asn Gly His Cys  Val Pro His Gly Trp  Leu Cys Asp 
    1385                 1390                 1395             


Asn Gln  Asp Asp Cys Gly Asp  Gly Ser Asp Glu Glu  Gly Cys Ala 
    1400                 1405                 1410             


Ala Pro  Gly Cys Gly Glu Gly  Gln Met Thr Cys Ser  Ser Gly His 
    1415                 1420                 1425             


Cys Leu  Pro Leu Ala Leu Leu  Cys Asp Arg Gln Asp  Asp Cys Gly 
    1430                 1435                 1440             


Asp Gly  Thr Asp Glu Pro Ser  Tyr Pro Cys Pro Gln  Gly Leu Leu 
    1445                 1450                 1455             


Ala Cys  Ala Asp Gly Arg Cys  Leu Pro Pro Ala Leu  Leu Cys Asp 
    1460                 1465                 1470             


Gly His  Pro Asp Cys Leu Asp  Ala Ala Asp Glu Glu  Ser Cys Leu 
    1475                 1480                 1485             


Gly Gln  Val Thr Cys Val Pro  Gly Glu Val Ser Cys  Val Asp Gly 
    1490                 1495                 1500             


Thr Cys  Leu Gly Ala Ile Gln  Leu Cys Asp Gly Val  Trp Asp Cys 
    1505                 1510                 1515             


Pro Asp  Gly Ala Asp Glu Gly  Pro Gly His Cys Pro  Leu Pro Ser 
    1520                 1525                 1530             


Leu Pro  Thr Pro Pro Ala Ser  Thr Leu Pro Gly Pro  Ser Pro Gly 
    1535                 1540                 1545             


Ser Leu  Asp Thr Ala Ser Ser  Pro Leu Ala Ser Ala  Ser Pro Ala 
    1550                 1555                 1560             


Pro Pro  Cys Gly Pro Phe Glu  Phe Arg Cys Gly Ser  Gly Glu Cys 
    1565                 1570                 1575             


Thr Pro  Arg Gly Trp Arg Cys  Asp Gln Glu Glu Asp  Cys Ala Asp 
    1580                 1585                 1590             


Gly Ser  Asp Glu Arg Gly Cys  Gly Gly Pro Cys Ala  Pro His His 
    1595                 1600                 1605             


Ala Pro  Cys Ala Arg Gly Pro  His Cys Val Ser Pro  Glu Gln Leu 
    1610                 1615                 1620             


Cys Asp  Gly Val Arg Gln Cys  Pro Asp Gly Ser Asp  Glu Gly Pro 
    1625                 1630                 1635             


Asp Ala  Cys Gly Gly Leu Pro  Ala Leu Gly Gly Pro  Asn Arg Thr 
    1640                 1645                 1650             


Gly Leu  Pro Cys Pro Glu Tyr  Thr Cys Pro Asn Gly  Thr Cys Ile 
    1655                 1660                 1665             


Gly Phe  Gln Leu Val Cys Asp  Gly Gln Pro Asp Cys  Gly Arg Pro 
    1670                 1675                 1680             


Gly Gln  Val Gly Pro Ser Pro  Glu Glu Gln Gly Cys  Gly Ala Trp 
    1685                 1690                 1695             


Gly Pro  Trp Ser Pro Trp Gly  Pro Cys Ser Arg Thr  Cys Gly Pro 
    1700                 1705                 1710             


Trp Gly  Gln Gly Arg Ser Arg  Arg Cys Ser Pro Leu  Gly Leu Leu 
    1715                 1720                 1725             


Val Leu  Gln Asn Cys Pro Gly  Pro Glu His Gln Ser  Gln Ala Cys 
    1730                 1735                 1740             


Phe Thr  Ala Ala Cys Pro Val  Asp Gly Glu Trp Ser  Thr Trp Ser 
    1745                 1750                 1755             


Pro Trp  Ser Val Cys Ser Glu  Pro Cys Arg Gly Thr  Met Thr Arg 
    1760                 1765                 1770             


Gln Arg  Gln Cys His Ser Pro  Gln Asn Gly Gly Arg  Thr Cys Ala 
    1775                 1780                 1785             


Ala Leu  Pro Gly Gly Leu His  Ser Thr Arg Gln Thr  Lys Pro Cys 
    1790                 1795                 1800             


Pro Gln  Asp Gly Cys Pro Asn  Ala Thr Cys Ser Gly  Glu Leu Met 
    1805                 1810                 1815             


Phe Gln  Pro Cys Ala Pro Cys  Pro Leu Thr Cys Asp  Asp Ile Ser 
    1820                 1825                 1830             


Gly Gln  Val Thr Cys Pro Pro  Asp Trp Pro Cys Gly  Ser Pro Gly 
    1835                 1840                 1845             


Cys Trp  Cys Pro Glu Gly Gln  Val Leu Gly Ser Glu  Gly Trp Cys 
    1850                 1855                 1860             


Val Trp  Pro Arg Gln Cys Pro  Cys Leu Val Asp Gly  Ala Arg Tyr 
    1865                 1870                 1875             


Trp Pro  Gly Gln Arg Ile Lys  Ala Asp Cys Gln Leu  Cys Ile Cys 
    1880                 1885                 1890             


Gln Asp  Gly Arg Pro Arg Arg  Cys Arg Leu Asn Pro  Asp Cys Ala 
    1895                 1900                 1905             


Val Asp  Cys Gly Trp Ser Ser  Trp Ser Pro Trp Ala  Lys Cys Leu 
    1910                 1915                 1920             


Gly Pro  Cys Gly Ser Gln Ser  Ile Gln Trp Ser Phe  Arg Ser Ser 
    1925                 1930                 1935             


Asn Asn  Pro Arg Pro Ser Gly  Arg Gly Arg Gln Cys  Arg Gly Ile 
    1940                 1945                 1950             


His Arg  Lys Ala Arg Arg Cys  Gln Thr Glu Pro Cys  Glu Gly Cys 
    1955                 1960                 1965             


Glu His  Gln Gly Gln Val His  Arg Val Gly Glu Arg  Trp His Gly 
    1970                 1975                 1980             


Gly Pro  Cys Arg Val Cys Gln  Cys Leu His Asn Leu  Thr Ala His 
    1985                 1990                 1995             


Cys Ser  Pro Tyr Cys Pro Leu  Gly Ser Cys Pro Gln  Gly Trp Val 
    2000                 2005                 2010             


Leu Val  Glu Gly Thr Gly Glu  Ser Cys Cys His Cys  Ala Leu Pro 
    2015                 2020                 2025             


Gly Glu  Asn Gln Thr Val Gln  Pro Met Ala Thr Pro  Ala Ala Ala 
    2030                 2035                 2040             


Pro Ala  Pro Ser Pro Gln Ile  Arg Phe Pro Leu Ala  Thr Tyr Ile 
    2045                 2050                 2055             


Leu Pro  Pro Ser Gly Asp Pro  Cys Tyr Ser Pro Leu  Gly Leu Ala 
    2060                 2065                 2070             


Gly Leu  Ala Glu Gly Ser Leu  His Ala Ser Ser Gln  Gln Leu Glu 
    2075                 2080                 2085             


His Pro  Thr Gln Ala Ala Leu  Leu Gly Ala Pro Thr  Gln Gly Pro 
    2090                 2095                 2100             


Ser Pro  Gln Gly Trp His Ala  Gly Gly Asp Ala Tyr  Ala Lys Trp 
    2105                 2110                 2115             


His Thr  Arg Pro His Tyr Leu  Gln Leu Asp Leu Leu  Gln Pro Arg 
    2120                 2125                 2130             


Asn Leu  Thr Gly Ile Leu Val  Pro Glu Thr Gly Ser  Ser Asn Ala 
    2135                 2140                 2145             


Tyr Ala  Ser Ser Phe Ser Leu  Gln Phe Ser Ser Asn  Gly Leu His 
    2150                 2155                 2160             


Trp His  Asp Tyr Arg Asp Leu  Leu Pro Gly Ile Leu  Pro Leu Pro 
    2165                 2170                 2175             


Lys Leu  Phe Pro Arg Asn Trp  Asp Asp Leu Asp Pro  Ala Val Trp 
    2180                 2185                 2190             


Thr Phe  Gly Arg Met Val Gln  Ala Arg Phe Val Arg  Val Trp Pro 
    2195                 2200                 2205             


His Asp  Val His His Ser Asp  Val Pro Leu Gln Val  Glu Leu Leu 
    2210                 2215                 2220             


Gly Cys  Glu Pro Gly Ser Pro  Pro Ala Pro Leu Cys  Pro Gly Val 
    2225                 2230                 2235             


Gly Leu  Arg Cys Ala Ser Gly  Glu Cys Val Leu Arg  Gly Gly Pro 
    2240                 2245                 2250             


Cys Asp  Gly Val Leu Asp Cys  Glu Asp Gly Ser Asp  Glu Glu Gly 
    2255                 2260                 2265             


Cys Val  Leu Leu Pro Glu Gly  Thr Gly Arg Phe His  Ser Thr Ala 
    2270                 2275                 2280             


Lys Thr  Leu Ala Leu Ser Ser  Ala Gln Pro Gly Gln  Leu Leu His 
    2285                 2290                 2295             


Trp Pro  Arg Glu Gly Leu Ala  Glu Thr Glu His Trp  Pro Pro Gly 
    2300                 2305                 2310             


Gln Glu  Ser Pro Thr Ser Pro  Thr Glu Thr Arg Pro  Val Ser Pro 
    2315                 2320                 2325             


Gly Pro  Ala Ser Gly Val Pro  His His Gly Glu Ser  Val Gln Met 
    2330                 2335                 2340             


Val Thr  Thr Thr Pro Ile Pro  Gln Met Glu Ala Arg  Thr Leu Pro 
    2345                 2350                 2355             


Pro Gly  Met Ala Ala Val Thr  Val Val Pro Pro His  Pro Val Thr 
    2360                 2365                 2370             


Pro Ala  Thr Pro Ala Gly Gln  Ser Val Ala Pro Gly  Pro Phe Pro 
    2375                 2380                 2385             


Pro Val  Gln Cys Gly Pro Gly  Gln Thr Pro Cys Glu  Val Leu Gly 
    2390                 2395                 2400             


Cys Val  Glu Gln Ala Gln Val  Cys Asp Gly Arg Glu  Asp Cys Leu 
    2405                 2410                 2415             


Asp Gly  Ser Asp Glu Arg His  Cys Ala Arg Asn Leu  Leu Met Trp 
    2420                 2425                 2430             


Leu Pro  Ser Leu Pro Ala Leu  Trp Ala Ala Ser Thr  Val Pro Phe 
    2435                 2440                 2445             


Met Met  Pro Thr Met Ala Leu  Pro Gly Leu Pro Ala  Ser Arg Ala 
    2450                 2455                 2460             


Leu Cys  Ser Pro Ser Gln Leu  Ser Cys Gly Ser Gly  Glu Cys Leu 
    2465                 2470                 2475             


Ser Ala  Glu Arg Arg Cys Asp  Leu Arg Pro Asp Cys  Gln Asp Gly 
    2480                 2485                 2490             


Ser Asp  Glu Asp Gly Cys Val  Asp Cys Val Leu Ala  Pro Trp Ser 
    2495                 2500                 2505             


Val Trp  Ser Ser Cys Ser Arg  Ser Cys Gly Leu Gly  Leu Thr Phe 
    2510                 2515                 2520             


Gln Arg  Gln Glu Leu Leu Arg  Pro Pro Leu Pro Gly  Gly Ser Cys 
    2525                 2530                 2535             


Pro Arg  Asp Arg Phe Arg Ser  Gln Ser Cys Phe Val  Gln Ala Cys 
    2540                 2545                 2550             


Pro Val  Ala Gly Ala Trp Ala  Met Trp Glu Ala Trp  Gly Pro Cys 
    2555                 2560                 2565             


Ser Val  Ser Cys Gly Gly Gly  His Gln Ser Arg Gln  Arg Ser Cys 
    2570                 2575                 2580             


Val Asp  Pro Pro Pro Lys Asn  Gly Gly Ala Pro Cys  Pro Gly Ala 
    2585                 2590                 2595             


Ser Gln  Glu Arg Ala Pro Cys  Gly Leu Gln Pro Cys  Ser Gly Gly 
    2600                 2605                 2610             


Thr Asp  Cys Glu Leu Gly Arg  Val Tyr Val Ser Ala  Asp Leu Cys 
    2615                 2620                 2625             


Gln Lys  Gly Leu Val Pro Pro  Cys Pro Pro Ser Cys  Leu Asp Pro 
    2630                 2635                 2640             


Lys Ala  Asn Arg Ser Cys Ser  Gly His Cys Val Glu  Gly Cys Arg 
    2645                 2650                 2655             


Cys Pro  Pro Gly Leu Leu Leu  His Asp Thr Arg Cys  Leu Pro Leu 
    2660                 2665                 2670             


Ser Glu  Cys Pro Cys Leu Val  Gly Glu Glu Leu Lys  Trp Pro Gly 
    2675                 2680                 2685             


Val Ser  Phe Leu Leu Gly Asn  Cys Ser Gln Cys Val  Cys Glu Lys 
    2690                 2695                 2700             


Gly Glu  Leu Leu Cys Gln Pro  Gly Gly Cys Pro Leu  Pro Cys Gly 
    2705                 2710                 2715             


Trp Ser  Ala Trp Ser Ser Trp  Ala Pro Cys Asp Arg  Ser Cys Gly 
    2720                 2725                 2730             


Ser Gly  Val Arg Ala Arg Phe  Arg Ser Pro Ser Asn  Pro Pro Ala 
    2735                 2740                 2745             


Ala Trp  Gly Gly Ala Pro Cys  Glu Gly Asp Arg Gln  Glu Leu Gln 
    2750                 2755                 2760             


Gly Cys  His Thr Val Cys Gly  Thr Glu Val Phe Gly  Trp Thr Pro 
    2765                 2770                 2775             


Trp Thr  Ser Trp Ser Ser Cys  Ser Gln Ser Cys Leu  Ala Pro Gly 
    2780                 2785                 2790             


Gly Gly  Pro Gly Trp Arg Ser  Arg Ser Arg Leu Cys  Pro Ser Pro 
    2795                 2800                 2805             


Gly Asp  Ser Ser Cys Pro Gly  Asp Ala Thr Gln Glu  Glu Pro Cys 
    2810                 2815                 2820             


Ser Pro  Pro Val Cys Pro Val  Pro Ser Ile Trp Gly  Leu Trp Ala 
    2825                 2830                 2835             


Pro Trp  Ser Thr Cys Ser Ala  Pro Cys Asp Gly Gly  Ile Gln Thr 
    2840                 2845                 2850             


Arg Gly  Arg Ser Cys Ser Ser  Leu Ala Pro Gly Asp  Thr Thr Cys 
    2855                 2860                 2865             


Pro Gly  Pro His Ser Gln Thr  Arg Asp Cys Asn Thr  Gln Pro Cys 
    2870                 2875                 2880             


Thr Ala  Gln Cys Pro Glu Asn  Met Leu Phe Arg Ser  Ala Glu Gln 
    2885                 2890                 2895             


Cys His  Gln Glu Gly Gly Pro  Cys Pro Arg Leu Cys  Leu Thr Gln 
    2900                 2905                 2910             


Gly Pro  Gly Ile Glu Cys Thr  Gly Phe Cys Ala Pro  Gly Cys Thr 
    2915                 2920                 2925             


Cys Pro  Pro Gly Leu Phe Leu  His Asn Ala Ser Cys  Leu Pro Arg 
    2930                 2935                 2940             


Ser Gln  Cys Pro Cys Gln Leu  His Gly Gln Leu Tyr  Ala Ser Gly 
    2945                 2950                 2955             


Ala Met  Ala Arg Leu Asp Ser  Cys Asn Asn Cys Thr  Cys Val Ser 
    2960                 2965                 2970             


Gly Lys  Met Ala Cys Thr Ser  Glu Arg Cys Pro Val  Ala Cys Gly 
    2975                 2980                 2985             


Trp Ser  Pro Trp Thr Leu Trp  Ser Leu Cys Ser Cys  Ser Cys Asn 
    2990                 2995                 3000             


Val Gly  Ile Arg Arg Arg Phe  Arg Ala Gly Thr Ala  Pro Pro Ala 
    3005                 3010                 3015             


Ala Phe  Gly Gly Ala Glu Cys  Gln Gly Pro Thr Met  Glu Ala Glu 
    3020                 3025                 3030             


Phe Cys  Ser Leu Arg Pro Cys  Pro Gly Pro Gly Gly  Glu Trp Gly 
    3035                 3040                 3045             


Pro Trp  Ser Pro Cys Ser Val  Pro Cys Gly Gly Gly  Tyr Arg Asn 
    3050                 3055                 3060             


Arg Thr  Arg Gly Ser Ser Arg  Ser Leu Met Glu Phe  Ser Thr Cys 
    3065                 3070                 3075             


Gly Leu  Gln Pro Cys Ala Gly  Pro Val Pro Gly Met  Cys Pro Arg 
    3080                 3085                 3090             


Asp Lys  Gln Trp Leu Asp Cys  Ala Gln Gly Pro Ala  Ser Cys Ala 
    3095                 3100                 3105             


Glu Leu  Ser Ala Pro Arg Gly  Thr Asn Gln Thr Cys  His Pro Gly 
    3110                 3115                 3120             


Cys His  Cys Pro Ser Gly Met  Leu Leu Leu Asn Asn  Val Cys Val 
    3125                 3130                 3135             


Pro Thr  Gln Asp Cys Pro Cys  Ala His Glu Gly His  Leu Tyr Pro 
    3140                 3145                 3150             


Pro Gly  Ser Thr Val Val Arg  Pro Cys Glu Asn Cys  Ser Cys Val 
    3155                 3160                 3165             


Ser Gly  Leu Ile Ala Asn Cys  Ser Ser Trp Pro Cys  Ala Glu Gly 
    3170                 3175                 3180             


Glu Pro  Thr Trp Ser Pro Trp  Thr Pro Trp Ser Gln  Cys Ser Ala 
    3185                 3190                 3195             


Ser Cys  Gly Pro Ala Arg Cys  His Arg His Arg Phe  Cys Ala Arg 
    3200                 3205                 3210             


Ser Pro  Ser Ala Val Pro Ser  Thr Val Ala Pro Leu  Pro Leu Pro 
    3215                 3220                 3225             


Ala Thr  Pro Thr Pro Leu Cys  Ser Gly Pro Glu Ala  Glu Glu Glu 
    3230                 3235                 3240             


Pro Cys  Leu Leu Gln Gly Cys  Asp Arg Ala Gly Gly  Trp Gly Pro 
    3245                 3250                 3255             


Trp Gly  Pro Trp Ser His Cys  Ser Arg Ser Cys Gly  Gly Gly Leu 
    3260                 3265                 3270             


Arg Ser  Arg Thr Arg Ala Cys  Asp Gln Pro Pro Pro  Gln Gly Leu 
    3275                 3280                 3285             


Gly Asp  Tyr Cys Glu Gly Pro  Arg Ala Gln Gly Glu  Val Cys Gln 
    3290                 3295                 3300             


Ala Leu  Pro Cys Pro Val Thr  Asn Cys Thr Ala Ile  Glu Gly Ala 
    3305                 3310                 3315             


Glu Tyr  Ser Pro Cys Gly Pro  Pro Cys Pro Arg Ser  Cys Asp Asp 
    3320                 3325                 3330             


Leu Val  His Cys Val Trp Arg  Cys Gln Pro Gly Cys  Tyr Cys Pro 
    3335                 3340                 3345             


Pro Gly  Gln Val Leu Ser Ser  Asn Gly Ala Ile Cys  Val Gln Pro 
    3350                 3355                 3360             


Gly His  Cys Ser Cys Leu Asp  Leu Leu Thr Gly Gln  Arg His His 
    3365                 3370                 3375             


Pro Gly  Ala Arg Leu Ala Arg  Pro Asp Gly Cys Asn  His Cys Thr 
    3380                 3385                 3390             


Cys Leu  Glu Gly Arg Leu Asn  Cys Thr Asp Leu Pro  Cys Pro Val 
    3395                 3400                 3405             


Pro Gly  Gly Trp Cys Pro Trp  Ser Glu Trp Thr Met  Cys Ser Gln 
    3410                 3415                 3420             


Pro Cys  Arg Gly Gln Thr Arg  Ser Arg Ser Arg Ala  Cys Ala Cys 
    3425                 3430                 3435             


Pro Thr  Pro Gln His Gly Gly  Ala Pro Cys Thr Gly  Glu Ala Gly 
    3440                 3445                 3450             


Glu Ala  Gly Ala Gln His Gln  Arg Glu Ala Cys Pro  Ser Tyr Ala 
    3455                 3460                 3465             


Thr Cys  Pro Val Asp Gly Ala  Trp Gly Pro Trp Gly  Pro Trp Ser 
    3470                 3475                 3480             


Pro Cys  Asp Met Cys Leu Gly  Gln Ser His Arg Ser  Arg Ala Cys 
    3485                 3490                 3495             


Ser Arg  Pro Pro Thr Pro Glu  Gly Gly Arg Pro Cys  Pro Gly Asn 
    3500                 3505                 3510             


His Thr  Gln Ser Arg Pro Cys  Gln Glu Asn Ser Thr  Gln Cys Thr 
    3515                 3520                 3525             


Asp Cys  Gly Gly Gly Gln Ser  Leu His Pro Cys Gly  Gln Pro Cys 
    3530                 3535                 3540             


Pro Arg  Ser Cys Gln Asp Leu  Ser Pro Gly Ser Val  Cys Gln Pro 
    3545                 3550                 3555             


Gly Ser  Val Gly Cys Gln Pro  Thr Cys Gly Cys Pro  Leu Gly Gln 
    3560                 3565                 3570             


Leu Ser  Gln Asp Gly Leu Cys  Val Pro Pro Ala His  Cys Arg Cys 
    3575                 3580                 3585             


Gln Tyr  Gln Pro Gly Ala Met  Gly Ile Pro Glu Asn  Gln Ser Arg 
    3590                 3595                 3600             


Ser Ala  Gly Ser Arg Phe Ser  Ser Trp Glu Ser Leu  Glu Pro Gly 
    3605                 3610                 3615             


Glu Val  Val Thr Gly Pro Cys  Asp Asn Cys Thr Cys  Val Ala Gly 
    3620                 3625                 3630             


Ile Leu  Gln Cys Gln Glu Val  Pro Asp Cys Pro Asp  Pro Gly Val 
    3635                 3640                 3645             


Trp Ser  Ser Trp Gly Pro Trp  Glu Asp Cys Ser Val  Ser Cys Gly 
    3650                 3655                 3660             


Gly Gly  Glu Gln Leu Arg Ser  Arg Arg Cys Ala Arg  Pro Pro Cys 
    3665                 3670                 3675             


Pro Gly  Pro Ala Arg Gln Ser  Arg Thr Cys Ser Thr  Gln Val Cys 
    3680                 3685                 3690             


Arg Glu  Ala Gly Cys Pro Ala  Gly Arg Leu Tyr Arg  Glu Cys Gln 
    3695                 3700                 3705             


Pro Gly  Glu Gly Cys Pro Phe  Ser Cys Ala His Val  Thr Gln Gln 
    3710                 3715                 3720             


Val Gly  Cys Phe Ser Glu Gly  Cys Glu Glu Gly Cys  His Cys Pro 
    3725                 3730                 3735             


Glu Gly  Thr Phe Gln His Arg  Leu Ala Cys Val Gln  Glu Cys Pro 
    3740                 3745                 3750             


Cys Val  Leu Thr Ala Trp Leu  Leu Gln Glu Leu Gly  Ala Thr Ile 
    3755                 3760                 3765             


Gly Asp  Pro Gly Gln Pro Leu  Gly Pro Gly Asp Glu  Leu Asp Ser 
    3770                 3775                 3780             


Gly Gln  Thr Leu Arg Thr Ser  Cys Gly Asn Cys Ser  Cys Ala His 
    3785                 3790                 3795             


Gly Lys  Leu Ser Cys Ser Leu  Asp Asp Cys Phe Glu  Ala Asp Gly 
    3800                 3805                 3810             


Gly Phe  Gly Pro Trp Ser Pro  Trp Gly Pro Cys Ser  Arg Ser Cys 
    3815                 3820                 3825             


Gly Gly  Leu Gly Thr Arg Thr  Arg Ser Arg Gln Cys  Val Leu Thr 
    3830                 3835                 3840             


Met Pro  Thr Leu Ser Gly Gln  Gly Cys Arg Gly Pro  Arg Gln Asp 
    3845                 3850                 3855             


Leu Glu  Tyr Cys Pro Ser Pro  Asp Cys Pro Gly Ala  Glu Gly Ser 
    3860                 3865                 3870             


Thr Val  Glu Pro Val Thr Gly  Leu Pro Gly Gly Trp  Gly Pro Trp 
    3875                 3880                 3885             


Ser Ser  Trp Ser Pro Cys Ser  Arg Ser Cys Thr Asp  Pro Ala Arg 
    3890                 3895                 3900             


Pro Ala  Trp Arg Ser Arg Thr  Arg Leu Cys Leu Ala  Asn Cys Thr 
    3905                 3910                 3915             


Met Gly  Asp Pro Leu Gln Glu  Arg Pro Cys Asn Leu  Pro Ser Cys 
    3920                 3925                 3930             


Thr Glu  Leu Pro Val Cys Pro  Gly Pro Gly Cys Gly  Ala Gly Asn 
    3935                 3940                 3945             


Cys Ser  Trp Thr Ser Trp Ala  Pro Trp Glu Pro Cys  Ser Arg Ser 
    3950                 3955                 3960             


Cys Gly  Val Gly Gln Gln Arg  Arg Leu Arg Ala Tyr  Arg Pro Pro 
    3965                 3970                 3975             


Gly Pro  Gly Gly His Trp Cys  Pro Asn Ile Leu Thr  Ala Tyr Gln 
    3980                 3985                 3990             


Glu Arg  Arg Phe Cys Asn Leu  Arg Ala Cys Pro Val  Pro Gly Gly 
    3995                 4000                 4005             


Trp Ser  Arg Trp Ser Pro Trp  Ser Trp Cys Asp Arg  Ser Cys Gly 
    4010                 4015                 4020             


Gly Gly  Gln Ser Leu Arg Ser  Arg Ser Cys Ser Ser  Pro Pro Ser 
    4025                 4030                 4035             


Lys Asn  Gly Gly Ala Pro Cys  Ala Gly Glu Arg His  Gln Ala Arg 
    4040                 4045                 4050             


Leu Cys  Asn Pro Met Pro Cys  Glu Ala Gly Cys Pro  Ala Gly Met 
    4055                 4060                 4065             


Glu Val  Val Thr Cys Ala Asn  Arg Cys Pro Arg Arg  Cys Ser Asp 
    4070                 4075                 4080             


Leu Gln  Glu Gly Ile Val Cys  Gln Asp Asp Gln Val  Cys Gln Lys 
    4085                 4090                 4095             


Gly Cys  Arg Cys Pro Lys Gly  Ser Leu Glu Gln Asp  Gly Gly Cys 
    4100                 4105                 4110             


Val Pro  Ile Gly His Cys Asp  Cys Thr Asp Ala Gln  Gly His Ser 
    4115                 4120                 4125             


Trp Ala  Pro Gly Ser Gln His  Gln Asp Ala Cys Asn  Asn Cys Ser 
    4130                 4135                 4140             


Cys Gln  Ala Gly Gln Leu Ser  Cys Thr Ala Gln Pro  Cys Pro Pro 
    4145                 4150                 4155             


Pro Thr  His Cys Ala Trp Ser  His Trp Ser Ala Trp  Ser Pro Cys 
    4160                 4165                 4170             


Ser His  Ser Cys Gly Pro Arg  Gly Gln Gln Ser Arg  Phe Arg Ser 
    4175                 4180                 4185             


Ser Thr  Ser Gly Ser Trp Ala  Pro Glu Cys Arg Glu  Glu Gln Ser 
    4190                 4195                 4200             


Gln Ser  Gln Pro Cys Pro Gln  Pro Ser Cys Pro Pro  Leu Cys Leu 
    4205                 4210                 4215             


Gln Gly  Thr Arg Ser Arg Thr  Leu Gly Asp Ser Trp  Leu Gln Gly 
    4220                 4225                 4230             


Glu Cys  Gln Arg Cys Ser Cys  Thr Pro Glu Gly Val  Ile Cys Glu 
    4235                 4240                 4245             


Asp Thr  Glu Cys Ala Val Pro  Glu Ala Trp Thr Leu  Trp Ser Ser 
    4250                 4255                 4260             


Trp Ser  Asp Cys Pro Val Ser  Cys Gly Gly Gly Asn  Gln Val Arg 
    4265                 4270                 4275             


Thr Arg  Ala Cys Arg Ala Ala  Ala Pro His His Arg  Ser Pro Pro 
    4280                 4285                 4290             


Cys Leu  Gly Pro Asp Thr Gln  Thr Arg Gln Gln Pro  Cys Pro Gly 
    4295                 4300                 4305             


Leu Leu  Glu Ala Cys Ser Trp  Gly Pro Trp Gly Pro  Cys Ser Arg 
    4310                 4315                 4320             


Ser Cys  Gly Pro Gly Leu Ala  Ser Arg Ser Gly Ser  Cys Pro Cys 
    4325                 4330                 4335             


Leu Met  Ala Lys Ala Asp Pro  Thr Cys Asn Ser Thr  Phe Leu His 
    4340                 4345                 4350             


Leu Asp  Thr Gln Gly Cys Tyr  Ser Gly Pro Cys Pro  Glu Glu Cys 
    4355                 4360                 4365             


Val Trp  Ser Ser Trp Ser Ser  Trp Thr Arg Cys Ser  Cys Arg Val 
    4370                 4375                 4380             


Leu Val  Gln Gln Arg Tyr Arg  His Gln Gly Pro Ala  Ser Arg Gly 
    4385                 4390                 4395             


Ala Arg  Ala Gly Ala Pro Cys  Thr Arg Leu Asp Gly  His Phe Arg 
    4400                 4405                 4410             


Pro Cys  Leu Ile Ser Asn Cys  Ser Glu Asp Ser Cys  Thr Pro Pro 
    4415                 4420                 4425             


Phe Glu  Phe His Ala Cys Gly  Ser Pro Cys Ala Gly  Leu Cys Ala 
    4430                 4435                 4440             


Thr His  Leu Ser His Gln Leu  Cys Gln Asp Leu Pro  Pro Cys Gln 
    4445                 4450                 4455             


Pro Gly  Cys Tyr Cys Pro Lys  Gly Leu Leu Glu Gln  Ala Gly Gly 
    4460                 4465                 4470             


Cys Ile  Pro Pro Glu Glu Cys  Asn Cys Trp His Thr  Ser Ala Ala 
    4475                 4480                 4485             


Gly Ala  Gly Met Thr Leu Ala  Pro Gly Asp Arg Leu  Gln Leu Gly 
    4490                 4495                 4500             


Cys Lys  Glu Cys Glu Cys Arg  Arg Gly Glu Leu His  Cys Thr Ser 
    4505                 4510                 4515             


Gln Gly  Cys Gln Gly Leu Leu  Pro Leu Ser Glu Trp  Ser Glu Trp 
    4520                 4525                 4530             


Ser Pro  Cys Gly Pro Cys Leu  Pro Pro Ser Ala Leu  Ala Pro Ala 
    4535                 4540                 4545             


Ser Arg  Thr Ala Leu Glu Glu  His Trp Leu Arg Asp  Pro Thr Gly 
    4550                 4555                 4560             


Leu Ser  Pro Thr Leu Ala Pro  Leu Leu Ala Ser Glu  Gln His Arg 
    4565                 4570                 4575             


His Arg  Leu Cys Leu Asp Pro  Ala Thr Gly Arg Pro  Trp Thr Gly 
    4580                 4585                 4590             


Ala Pro  His Leu Cys Thr Ala  Pro Leu Ser Gln Gln  Arg Leu Cys 
    4595                 4600                 4605             


Pro Asp  Pro Gly Ala Cys Pro  Asp Ser Cys Gln Trp  Ser Leu Trp 
    4610                 4615                 4620             


Gly Pro  Trp Ser Pro Cys Gln  Val Pro Cys Ser Gly  Gly Phe Arg 
    4625                 4630                 4635             


Leu Arg  Trp Arg Glu Ala Glu  Ala Leu Cys Gly Gly  Gly Cys Arg 
    4640                 4645                 4650             


Glu Pro  Trp Ala Gln Glu Ser  Cys Asn Gly Gly Pro  Cys Pro Glu 
    4655                 4660                 4665             


Ser Cys  Glu Ala Gln Asp Thr  Val Phe Thr Leu Asp  Cys Ala Asn 
    4670                 4675                 4680             


Gln Cys  Pro His Ser Cys Ala  Asp Leu Trp Asp Arg  Val Gln Cys 
    4685                 4690                 4695             


Leu Gln  Gly Pro Cys Arg Pro  Gly Cys Arg Cys Pro  Pro Gly Gln 
    4700                 4705                 4710             


Leu Val  Gln Asp Gly Arg Cys  Val Pro Ile Ser Ser  Cys Arg Cys 
    4715                 4720                 4725             


Gly Leu  Pro Ser Ala Asn Ala  Ser Trp Glu Leu Ala  Pro Ala Gln 
    4730                 4735                 4740             


Ala Val  Gln Leu Asp Cys Gln  Asn Cys Thr Cys Val  Asn Glu Ser 
    4745                 4750                 4755             


Leu Val  Cys Pro His Gln Glu  Cys Pro Val Leu Gly  Pro Trp Ser 
    4760                 4765                 4770             


Ala Trp  Ser Ser Cys Ser Ala  Pro Cys Gly Gly Gly  Thr Met Glu 
    4775                 4780                 4785             


Arg His  Arg Thr Cys Glu Gly  Gly Pro Gly Val Ala  Pro Cys Gln 
    4790                 4795                 4800             


Ala Gln  Asp Thr Glu Gln Arg  Gln Glu Cys Asn Leu  Gln Pro Cys 
    4805                 4810                 4815             


Pro Glu  Cys Pro Pro Gly Gln  Val Leu Ser Ala Cys  Ala Thr Ser 
    4820                 4825                 4830             


Cys Pro  Cys Leu Cys Trp His  Leu Gln Pro Gly Ala  Ile Cys Val 
    4835                 4840                 4845             


Gln Glu  Pro Cys Gln Pro Gly  Cys Gly Cys Pro Gly  Gly Gln Leu 
    4850                 4855                 4860             


Leu His  Asn Gly Thr Cys Val  Pro Pro Thr Ala Cys  Pro Cys Thr 
    4865                 4870                 4875             


Gln His  Ser Leu Pro Trp Gly  Leu Thr Leu Thr Leu  Glu Glu Gln 
    4880                 4885                 4890             


Ala Gln  Glu Leu Pro Pro Gly  Thr Val Leu Thr Arg  Asn Cys Thr 
    4895                 4900                 4905             


Arg Cys  Val Cys His Gly Gly  Ala Phe Ser Cys Ser  Leu Val Asp 
    4910                 4915                 4920             


Cys Gln  Val Pro Pro Gly Glu  Thr Trp Gln Gln Val  Ala Pro Gly 
    4925                 4930                 4935             


Glu Leu  Gly Leu Cys Glu Gln  Thr Cys Leu Glu Met  Asn Ala Thr 
    4940                 4945                 4950             


Lys Thr  Gln Ser Asn Cys Ser  Ser Ala Arg Ala Ser  Gly Cys Val 
    4955                 4960                 4965             


Cys Gln  Pro Gly His Phe Arg  Ser Gln Ala Gly Pro  Cys Val Pro 
    4970                 4975                 4980             


Glu Asp  His Cys Glu Cys Trp  His Leu Gly Arg Pro  His Leu Pro 
    4985                 4990                 4995             


Gly Ser  Glu Trp Gln Glu Ala  Cys Glu Ser Cys Leu  Cys Leu Ser 
    5000                 5005                 5010             


Gly Arg  Pro Val Cys Thr Gln  His Cys Ser Pro Leu  Thr Cys Ala 
    5015                 5020                 5025             


Gln Gly  Glu Glu Met Val Leu  Glu Pro Gly Ser Cys  Cys Pro Ser 
    5030                 5035                 5040             


Cys Arg  Arg Glu Ala Pro Glu  Glu Gln Ser Pro Ser  Cys Gln Leu 
    5045                 5050                 5055             


Leu Thr  Glu Leu Arg Asn Phe  Thr Lys Gly Thr Cys  Tyr Leu Asp 
    5060                 5065                 5070             


Gln Val  Glu Val Ser Tyr Cys  Ser Gly Tyr Cys Pro  Ser Ser Thr 
    5075                 5080                 5085             


His Val  Met Pro Glu Glu Pro  Tyr Leu Gln Ser Gln  Cys Asp Cys 
    5090                 5095                 5100             


Cys Ser  Tyr Arg Leu Asp Pro  Glu Ser Pro Val Arg  Ile Leu Asn 
    5105                 5110                 5115             


Leu Arg  Cys Leu Gly Gly His  Thr Glu Pro Val Val  Leu Pro Val 
    5120                 5125                 5130             


Ile His  Ser Cys Gln Cys Ser  Ser Cys Gln Gly Gly  Asp Phe Ser 
    5135                 5140                 5145             


Lys Arg  
    5150 


<210>  75
<211>  5651
<212>  DNA
<213>  Homo sapiens

<400>  75
ctggtgtggc tggctgcggc cagaatcgga gccccaaccg cgctgccgct cggaccttag       60

cctgtgcctg cagcccggag tcccctcctg ccctggaagg caaggagcca ggccacgggg      120

ccacagccgc gggggccacc acactggccc aaatatttcc tgcagagtca acctatttga      180

tttcttgaca agaccacaat ctgatcccaa agatgtgctc cacaaatcca ggcaaatggg      240

tcacctttga tgatgatcct gctgttcaat cttctcaaaa gtcaaagaat tttcctctgg      300

agaatcaagg tgtctgtaga ccaaatggac tgaagctgaa ccttcctggc ctcagggaat      360

ttcccagtgg atcttcctcc accagcagca ctcctctctc ctcccccatt gtagattttt      420

atttcagtcc aggacctcca agtaactctc ctctttctac acctaccaaa gacttcccag      480

gttttcctgg catccccaaa gcagggactc atgtgcttta tcctattcca gaatcatctt      540

cagacagccc actcgcaata tcaggaggag aatcttcctt actgcctacc agaccaacat      600

gtttatccca tgccttgtta cccagtgacc actcatgtac acatccaact cccaaagtag      660

gtcttccaga tgaagttaat cctcaacagg ctgaaagcct aggattccaa agtgatgatc      720

tcccccagtt tcagtatttt cgagaggact gtgctttttc aagtccattt tggaaagatg      780

aaggcagtga ttcccatttc acccttgacc caccaggaag caaaaagatg ttctcatcaa      840

gaaacaagga gatgcctatt gaccaaaaaa gcctaaataa gtgttcactc aactatatct      900

gtgagaagct tgaacatctc cagtcagctg agaaccaaga ctcacttaga agtttgtcta      960

tgcactgtct atgtgctgaa gaaaatgcct cttcctttgt cccccacaca ctcttcagga     1020

gtcagccaaa atccggatgg tctttcatgc tgagaattcc tgagaagaag aatatgatgt     1080

cttcccggca atggggacca atttttctga aagttttgcc tggaggaatt ttgcagatgt     1140

attatgaaca gggattagaa aaaccattta aagagataca gcttgatcca tattgtaggc     1200

tttctgaacc caaggttgag aacttcagtg tagcaggaaa aatccacact gtgaagattg     1260

aacatgtgtc ttacacagaa aaaaggaaat accattctaa gacagaagta gttcatgaac     1320

ctgacataga gcagatgctg aagttggggt ccacatcgta ccatgacttc cttgactttc     1380

tgactactgt ggaggaggag ctgatgaagt tgccagctgt ttcaaaacca aaaaagaact     1440

acgaggagca agaaatttcc ttggaaattg tggacaactt ttggggtaaa gtcacaaaag     1500

aaggaaaatt tgttgaaagt gctgtgataa ctcaaattta ttgcctctgc tttgtgaatg     1560

ggaacctgga atgcttttta accttgaatg accttgagtt gccgaagcga gatgaatcct     1620

attatgagaa ggactcagaa aaaaagggga ttgatattct tgactaccat tttcataagt     1680

gtgtgaatgt acaagaattt gagcaatcaa gaatcattaa gtttgtacct ctggatgcct     1740

gccggtttga gctgatgcgt ttcaagactt tgtataatgg ggataatctt cccttttcct     1800

tgaagtctgt agtggttgtc cagggagcat acgtggaact tcaggctttt gtcaacatgg     1860

cctcattggc gcagaggtca tcctatgctg gttccttaag gtcctgtgac aatataagga     1920

tacactttcc tgtcccatcg cagtggatca aggccctttg gaccatgaac ctccagaggc     1980

agaagtctct gaaagctaaa atgaaccgcc gagcatgtct ggggagttta caggaacttg     2040

aatctgaacc tgtcattcaa gtcactgtgg ggtcagcaaa atatgagagt gcctaccagg     2100

cagtggtatg gaagatagat cggcttccag acaaaaattc aagtctagat catccccatt     2160

gtctgtcata caaattagag cttggatcag accaagaaat tccctctgat tggtatccat     2220

ttgctactgt tcagttttcc gtgcctgaca cctgtgcctc aaggacagag gtcaggtctc     2280

tgggagtgga gagtgatgtc cagccacaga aacatgttca gcagcgagct tgctacaaca     2340

tccaggttga aatagaaaag aagtggatta aaatcgatgg agaagaccca gataaaattg     2400

gtgactgcat aactcagtag gagtagcaag agtttatgat gacagcccac ttgtcaaata     2460

tgtaattcac cgaaaccaca ccaagtcctg ctactgtaga gtggaaatga cttctgaata     2520

gcggttttag gacaggtctg atggctgtgt ttagagaagt ttagacctaa aaccgaacaa     2580

tctgtatttt ttgcttttca tgtgtttttg tcctaggggt tcgatctaaa atgtttctat     2640

aattcgtgtg atgttttgct tcctattgaa actcaaaggc actgttactc gttgtgtgac     2700

cccgcagcca gtatgatttt tgattactca gtggctgact gttttgctct ctggattact     2760

gaggtgccgt cttcatttct tcccatctct tcttgctgct tagtgtctgt actagagggt     2820

aagggaatca aaggagacat aaaccaaaat agttaatttt ccctctttct tgcctctgaa     2880

atgtggctag gtgtagaatg atgttgaaac cacaggctaa aatgtagatc tggaagtatc     2940

tgtgcttttg aattacttat ttacctgtcc tcttaccgtt ggtaaataat aattggctat     3000

atttggtacc tgtctctctc ctactgtatt gtcattttca aaatgtgttt gttttctggc     3060

gcgtgctgca aagaagctat ttctgttgtc ctacatattt tagtataaat cactaagaca     3120

tatttccttt cacttggcag gattcctttc aaaatggaat ctgagtatta gacactagtt     3180

aacatatttg tgtatattaa atatgaattt ttaaaattta taaatactat tttccaaaag     3240

tacagactct aaggacatat tttgataaag tattatttgt aatgaacaca agcctctctt     3300

gagtagaagt ctaaatcaca ttatgattat tttatactag ttctgctatc atgctgtttt     3360

atgctaattc tgcttatttt agagtatttt tcattaaaag gtgagcaaag tgaaagatac     3420

ttggtatttt acccagattt ctaagtggca acatttttat tcttcagagt caggtaaatg     3480

actataatag tttggtttct aatgaaaagt caatagcatt agcagttata attctgttta     3540

taatttcctt tcagcattta cagtgaaaag tgagaatttt aaaatttatg aaatctatat     3600

tccaggtatt gtttttagtc tgaaaaacaa actcccccat gtggtattaa tataccttca     3660

atttatgttg agtcttaaac ataattagga gatatttttc tctatttgct agatttgttt     3720

tgagtcaaaa ctgatttagt gttcttccaa acaacattta tgtgttggcc tacagagttt     3780

atttcatgtg ttttttttaa tatttaatat tatattacat tcattgaaat ctgttcaaaa     3840

acagattaag acaaacattt atgatggtct gtatcaatca gcagatttta ttgcttttca     3900

ttattttact gtaaaggcaa agaatgcaat aggtgatggt tggttgaaag gaattgttat     3960

tgctgttttt attttttact ttttttgaga cagagtctca ctctgttgcc cagcctggag     4020

tgcagtgtgt catcttggct cactgcaacc tccgcctcct gggttcaagg gattctcctg     4080

cctcagcctc caactagctg ggattacagg cacaagccac catgcctggc taaaattctt     4140

ttgtattttt actacagacg gagtttcccc atgttggccg ggctagtctc gaactcctga     4200

cctcaggtga tccaccagcc tcggcctccc aaagttctgg gattaaatgc gtgagccacc     4260

atgcccggcc gctattgctc tttttaactt catttgatgc cttgcttata atatcatatg     4320

cttgaggctc actgttgatg tagagtaggg caaatctgtg tgtgtatgtc attaaaaaaa     4380

ttctaccatc tttctttatc atctggtgtg ggcgcactct acagtgactt cagtctgctc     4440

agaacgaatg tggaggccgg ccgaaactga tgctgcccac agtcccagtg aagttaggtg     4500

ggttaattac tgccattcct ttctaagtgt gttttatggc atcctgccca caaagaactc     4560

acagtctgat taggatgaac ttaatgacta tttacacctc aaaatatatt cagcaaaggg     4620

ttcacttagt tgcccctcat gcttcacagg ttgactagta tctgtgggta cctccctgcc     4680

caggttattc actcacaagc caccgggcct tcaggacatc tcaagattca gtcttgacaa     4740

tataatagca aaagctggac taaagcccaa atggattgtc tgtggcaatg cagaagctga     4800

tagcattaac agcagggtgt tacagcataa ttgttaattc gcacatctat taggatcctt     4860

aaatattcat tacttaatgt taaattaaca ttctgtgtag ggaggggagg cttattcaat     4920

tcttctgacc tcagaactgg cagaaggtca gatgtgacta cagaactcta ggtgaaaaat     4980

caggtagggt tcaaattaag tagaactgcc cttgccggaa tagtgatctt caaaaaaccc     5040

ttgcttttag gggagggaag cggggaagga aaggaatgag ggaggaaata ttcctttcta     5100

gcattcattt tgcttagatc actccattgt gagtttgacc attttggagt caaatgagca     5160

gacttccaag gagttgacca gtttgtgact agtctggtca cctttccagt tacaggatca     5220

tattaactgt gtaaatgaat tcatgggtag atgatttgtg cagatctgaa tttaagaaca     5280

tttccttttt ctgtgggaat cacaagagtt tatccactaa aaaaagatat gtaaaaaaga     5340

tactttccag cacataaata aaggctggaa ttttacaacc tgatgtatat attagacagt     5400

tctaggatgt tagttccctt cattccagag ctatgcttgt gatacagccc cttttcttat     5460

aaagtcagtt agaaggactt ccttaacaat gactattata atgtcttact taaaatacag     5520

ttttgtattc tgtcaatgca aatataagac aggttgagcc ttaatcatgt aacaaaatat     5580

tttgtagatt acatattgat ttttcaaaaa ttaaaaatgt atttcaaact attaaaaaaa     5640

aaaaaaaaaa a                                                          5651


<210>  76
<211>  735
<212>  PRT
<213>  Homo sapiens

<400>  76

Met Cys Ser Thr Asn Pro Gly Lys Trp Val Thr Phe Asp Asp Asp Pro 
1               5                   10                  15      


Ala Val Gln Ser Ser Gln Lys Ser Lys Asn Phe Pro Leu Glu Asn Gln 
            20                  25                  30          


Gly Val Cys Arg Pro Asn Gly Leu Lys Leu Asn Leu Pro Gly Leu Arg 
        35                  40                  45              


Glu Phe Pro Ser Gly Ser Ser Ser Thr Ser Ser Thr Pro Leu Ser Ser 
    50                  55                  60                  


Pro Ile Val Asp Phe Tyr Phe Ser Pro Gly Pro Pro Ser Asn Ser Pro 
65                  70                  75                  80  


Leu Ser Thr Pro Thr Lys Asp Phe Pro Gly Phe Pro Gly Ile Pro Lys 
                85                  90                  95      


Ala Gly Thr His Val Leu Tyr Pro Ile Pro Glu Ser Ser Ser Asp Ser 
            100                 105                 110         


Pro Leu Ala Ile Ser Gly Gly Glu Ser Ser Leu Leu Pro Thr Arg Pro 
        115                 120                 125             


Thr Cys Leu Ser His Ala Leu Leu Pro Ser Asp His Ser Cys Thr His 
    130                 135                 140                 


Pro Thr Pro Lys Val Gly Leu Pro Asp Glu Val Asn Pro Gln Gln Ala 
145                 150                 155                 160 


Glu Ser Leu Gly Phe Gln Ser Asp Asp Leu Pro Gln Phe Gln Tyr Phe 
                165                 170                 175     


Arg Glu Asp Cys Ala Phe Ser Ser Pro Phe Trp Lys Asp Glu Gly Ser 
            180                 185                 190         


Asp Ser His Phe Thr Leu Asp Pro Pro Gly Ser Lys Lys Met Phe Ser 
        195                 200                 205             


Ser Arg Asn Lys Glu Met Pro Ile Asp Gln Lys Ser Leu Asn Lys Cys 
    210                 215                 220                 


Ser Leu Asn Tyr Ile Cys Glu Lys Leu Glu His Leu Gln Ser Ala Glu 
225                 230                 235                 240 


Asn Gln Asp Ser Leu Arg Ser Leu Ser Met His Cys Leu Cys Ala Glu 
                245                 250                 255     


Glu Asn Ala Ser Ser Phe Val Pro His Thr Leu Phe Arg Ser Gln Pro 
            260                 265                 270         


Lys Ser Gly Trp Ser Phe Met Leu Arg Ile Pro Glu Lys Lys Asn Met 
        275                 280                 285             


Met Ser Ser Arg Gln Trp Gly Pro Ile Phe Leu Lys Val Leu Pro Gly 
    290                 295                 300                 


Gly Ile Leu Gln Met Tyr Tyr Glu Gln Gly Leu Glu Lys Pro Phe Lys 
305                 310                 315                 320 


Glu Ile Gln Leu Asp Pro Tyr Cys Arg Leu Ser Glu Pro Lys Val Glu 
                325                 330                 335     


Asn Phe Ser Val Ala Gly Lys Ile His Thr Val Lys Ile Glu His Val 
            340                 345                 350         


Ser Tyr Thr Glu Lys Arg Lys Tyr His Ser Lys Thr Glu Val Val His 
        355                 360                 365             


Glu Pro Asp Ile Glu Gln Met Leu Lys Leu Gly Ser Thr Ser Tyr His 
    370                 375                 380                 


Asp Phe Leu Asp Phe Leu Thr Thr Val Glu Glu Glu Leu Met Lys Leu 
385                 390                 395                 400 


Pro Ala Val Ser Lys Pro Lys Lys Asn Tyr Glu Glu Gln Glu Ile Ser 
                405                 410                 415     


Leu Glu Ile Val Asp Asn Phe Trp Gly Lys Val Thr Lys Glu Gly Lys 
            420                 425                 430         


Phe Val Glu Ser Ala Val Ile Thr Gln Ile Tyr Cys Leu Cys Phe Val 
        435                 440                 445             


Asn Gly Asn Leu Glu Cys Phe Leu Thr Leu Asn Asp Leu Glu Leu Pro 
    450                 455                 460                 


Lys Arg Asp Glu Ser Tyr Tyr Glu Lys Asp Ser Glu Lys Lys Gly Ile 
465                 470                 475                 480 


Asp Ile Leu Asp Tyr His Phe His Lys Cys Val Asn Val Gln Glu Phe 
                485                 490                 495     


Glu Gln Ser Arg Ile Ile Lys Phe Val Pro Leu Asp Ala Cys Arg Phe 
            500                 505                 510         


Glu Leu Met Arg Phe Lys Thr Leu Tyr Asn Gly Asp Asn Leu Pro Phe 
        515                 520                 525             


Ser Leu Lys Ser Val Val Val Val Gln Gly Ala Tyr Val Glu Leu Gln 
    530                 535                 540                 


Ala Phe Val Asn Met Ala Ser Leu Ala Gln Arg Ser Ser Tyr Ala Gly 
545                 550                 555                 560 


Ser Leu Arg Ser Cys Asp Asn Ile Arg Ile His Phe Pro Val Pro Ser 
                565                 570                 575     


Gln Trp Ile Lys Ala Leu Trp Thr Met Asn Leu Gln Arg Gln Lys Ser 
            580                 585                 590         


Leu Lys Ala Lys Met Asn Arg Arg Ala Cys Leu Gly Ser Leu Gln Glu 
        595                 600                 605             


Leu Glu Ser Glu Pro Val Ile Gln Val Thr Val Gly Ser Ala Lys Tyr 
    610                 615                 620                 


Glu Ser Ala Tyr Gln Ala Val Val Trp Lys Ile Asp Arg Leu Pro Asp 
625                 630                 635                 640 


Lys Asn Ser Ser Leu Asp His Pro His Cys Leu Ser Tyr Lys Leu Glu 
                645                 650                 655     


Leu Gly Ser Asp Gln Glu Ile Pro Ser Asp Trp Tyr Pro Phe Ala Thr 
            660                 665                 670         


Val Gln Phe Ser Val Pro Asp Thr Cys Ala Ser Arg Thr Glu Val Arg 
        675                 680                 685             


Ser Leu Gly Val Glu Ser Asp Val Gln Pro Gln Lys His Val Gln Gln 
    690                 695                 700                 


Arg Ala Cys Tyr Asn Ile Gln Val Glu Ile Glu Lys Lys Trp Ile Lys 
705                 710                 715                 720 


Ile Asp Gly Glu Asp Pro Asp Lys Ile Gly Asp Cys Ile Thr Gln 
                725                 730                 735 


<210>  77
<211>  3510
<212>  DNA
<213>  Homo sapiens

<400>  77
aaaatttcag cagagagaaa tagagaaagc agtgtgtgtg catgtgtgtg tgtgtgagag       60

agagagggag aggagcgaga gggagaggga gagggagaga gagaaaggga gggaagcaga      120

gagtcaagtc caagggaatg agcgagagag gcagagacag gggaagaggc gtgcgagaga      180

aggaataaca gctttccgga gcaggcgtgc cgtgaactgg cttctatttt attttatttt      240

tttctccttt ttatttttta aagagaagca ggggacagaa gcaatggccg aggcagaaga      300

caagccgagg tgctggtgac cctgggcgtc tgagtggatg attggggctg ctgcgctcag      360

aggcctgcct ccctgccttc caatgcatat aaccccacac cccagccaat gaagacgaga      420

ggcagcgtga acaaagtcat ttagaaagcc cccgaggaag tgtaaacaaa agagaaagca      480

tgaatggagt gcctgagaga caagtgtgtc ctgtactgcc cccaccttta gctgggccag      540

caactgcccg gccctgcttc tccccaccta ctcactggtg atcttttttt ttttactttt      600

ttttcccttt tcttttccat tctcttttct tattttcttt caaggcaagg caaggatttt      660

gattttggga cccagccatg gtccttctgc ttcttcttta aaatacccac tttctcccca      720

tcgccaagcg gcgtttggca atatcagata tccactctat ttatttttac ctaaggaaaa      780

actccagctc ccttcccact cccagctgcc ttgccacccc tcccagccct ctgcttgccc      840

tccacctggc ctgctgggag tcagagccca gcaaaacctg tttagacaca tggacaagaa      900

tcccagcgct acaaggcaca cagtccgctt cttcgtcctc agggttgcca gcgcttcctg      960

gaagtcctga agctctcgca gtgcagtgag ttcatgcacc ttcttgccaa gcctcagtct     1020

ttgggatctg gggaggccgc ctggttttcc tccctccttc tgcacgtctg ctggggtctc     1080

ttcctctcca ggccttgccg tccccctggc ctctcttccc agctcacaca tgaagatgca     1140

cttgcaaagg gctctggtgg tcctggccct gctgaacttt gccacggtca gcctctctct     1200

gtccacttgc accaccttgg acttcggcca catcaagaag aagagggtgg aagccattag     1260

gggacagatc ttgagcaagc tcaggctcac cagcccccct gagccaacgg tgatgaccca     1320

cgtcccctat caggtcctgg ccctttacaa cagcacccgg gagctgctgg aggagatgca     1380

tggggagagg gaggaaggct gcacccagga aaacaccgag tcggaatact atgccaaaga     1440

aatccataaa ttcgacatga tccaggggct ggcggagcac aacgaactgg ctgtctgccc     1500

taaaggaatt acctccaagg ttttccgctt caatgtgtcc tcagtggaga aaaatagaac     1560

caacctattc cgagcagaat tccgggtctt gcgggtgccc aaccccagct ctaagcggaa     1620

tgagcagagg atcgagctct tccagatcct tcggccagat gagcacattg ccaaacagcg     1680

ctatatcggt ggcaagaatc tgcccacacg gggcactgcc gagtggctgt cctttgatgt     1740

cactgacact gtgcgtgagt ggctgttgag aagagagtcc aacttaggtc tagaaatcag     1800

cattcactgt ccatgtcaca cctttcagcc caatggagat atcctggaaa acattcacga     1860

ggtgatggaa atcaaattca aaggcgtgga caatgaggat gaccatggcc gtggagatct     1920

ggggcgcctc aagaagcaga aggatcacca caaccctcat ctaatcctca tgatgattcc     1980

cccacaccgg ctcgacaacc cgggccaggg gggtcagagg aagaagcggg ctttggacac     2040

caattactgc ttccgcaact tggaggagaa ctgctgtgtg cgccccctct acattgactt     2100

ccgacaggat ctgggctgga agtgggtcca tgaacctaag ggctactatg ccaacttctg     2160

ctcaggccct tgcccatacc tccgcagtgc agacacaacc cacagcacgg tgctgggact     2220

gtacaacact ctgaaccctg aagcatctgc ctcgccttgc tgcgtgcccc aggacctgga     2280

gcccctgacc atcctgtact atgttgggag gacccccaaa gtggagcagc tctccaacat     2340

ggtggtgaag tcttgtaaat gtagctgaga ccccacgtgc gacagagaga ggggagagag     2400

aaccaccact gcctgactgc ccgctcctcg ggaaacacac aagcaacaaa cctcactgag     2460

aggcctggag cccacaacct tcggctccgg gcaaatggct gagatggagg tttccttttg     2520

gaacatttct ttcttgctgg ctctgagaat cacggtggta aagaaagtgt gggtttggtt     2580

agaggaaggc tgaactcttc agaacacaca gactttctgt gacgcagaca gaggggatgg     2640

ggatagagga aagggatggt aagttgagat gttgtgtggc aatgggattt gggctaccct     2700

aaagggagaa ggaagggcag agaatggctg ggtcagggcc agactggaag acacttcaga     2760

tctgaggttg gatttgctca ttgctgtacc acatctgctc tagggaatct ggattatgtt     2820

atacaaggca agcatttttt tttttttttt aaagacaggt tacgaagaca aagtcccaga     2880

attgtatctc atactgtctg ggattaaggg caaatctatt acttttgcaa actgtcctct     2940

acatcaatta acatcgtggg tcactacagg gagaaaatcc aggtcatgca gttcctggcc     3000

catcaactgt attgggcctt ttggatatgc tgaacgcaga agaaagggtg gaaatcaacc     3060

ctctcctgtc tgccctctgg gtccctcctc tcacctctcc ctcgatcata tttccccttg     3120

gacacttggt tagacgcctt ccaggtcagg atgcacattt ctggattgtg gttccatgca     3180

gccttggggc attatgggtt cttcccccac ttcccctcca agaccctgtg ttcatttggt     3240

gttcctggaa gcaggtgcta caacatgtga ggcattcggg gaagctgcac atgtgccaca     3300

cagtgacttg gccccagacg catagactga ggtataaaga caagtatgaa tattactctc     3360

aaaatctttg tataaataaa tatttttggg gcatcctgga tgatttcatc ttctggaata     3420

ttgtttctag aacagtaaaa gccttattct aaggtgtatg tctgactcga taaatatcct     3480

tcaattaccc ttaaaaaaaa aaaaaaaaaa                                      3510


<210>  78
<211>  412
<212>  PRT
<213>  Homo sapiens

<400>  78

Met Lys Met His Leu Gln Arg Ala Leu Val Val Leu Ala Leu Leu Asn 
1               5                   10                  15      


Phe Ala Thr Val Ser Leu Ser Leu Ser Thr Cys Thr Thr Leu Asp Phe 
            20                  25                  30          


Gly His Ile Lys Lys Lys Arg Val Glu Ala Ile Arg Gly Gln Ile Leu 
        35                  40                  45              


Ser Lys Leu Arg Leu Thr Ser Pro Pro Glu Pro Thr Val Met Thr His 
    50                  55                  60                  


Val Pro Tyr Gln Val Leu Ala Leu Tyr Asn Ser Thr Arg Glu Leu Leu 
65                  70                  75                  80  


Glu Glu Met His Gly Glu Arg Glu Glu Gly Cys Thr Gln Glu Asn Thr 
                85                  90                  95      


Glu Ser Glu Tyr Tyr Ala Lys Glu Ile His Lys Phe Asp Met Ile Gln 
            100                 105                 110         


Gly Leu Ala Glu His Asn Glu Leu Ala Val Cys Pro Lys Gly Ile Thr 
        115                 120                 125             


Ser Lys Val Phe Arg Phe Asn Val Ser Ser Val Glu Lys Asn Arg Thr 
    130                 135                 140                 


Asn Leu Phe Arg Ala Glu Phe Arg Val Leu Arg Val Pro Asn Pro Ser 
145                 150                 155                 160 


Ser Lys Arg Asn Glu Gln Arg Ile Glu Leu Phe Gln Ile Leu Arg Pro 
                165                 170                 175     


Asp Glu His Ile Ala Lys Gln Arg Tyr Ile Gly Gly Lys Asn Leu Pro 
            180                 185                 190         


Thr Arg Gly Thr Ala Glu Trp Leu Ser Phe Asp Val Thr Asp Thr Val 
        195                 200                 205             


Arg Glu Trp Leu Leu Arg Arg Glu Ser Asn Leu Gly Leu Glu Ile Ser 
    210                 215                 220                 


Ile His Cys Pro Cys His Thr Phe Gln Pro Asn Gly Asp Ile Leu Glu 
225                 230                 235                 240 


Asn Ile His Glu Val Met Glu Ile Lys Phe Lys Gly Val Asp Asn Glu 
                245                 250                 255     


Asp Asp His Gly Arg Gly Asp Leu Gly Arg Leu Lys Lys Gln Lys Asp 
            260                 265                 270         


His His Asn Pro His Leu Ile Leu Met Met Ile Pro Pro His Arg Leu 
        275                 280                 285             


Asp Asn Pro Gly Gln Gly Gly Gln Arg Lys Lys Arg Ala Leu Asp Thr 
    290                 295                 300                 


Asn Tyr Cys Phe Arg Asn Leu Glu Glu Asn Cys Cys Val Arg Pro Leu 
305                 310                 315                 320 


Tyr Ile Asp Phe Arg Gln Asp Leu Gly Trp Lys Trp Val His Glu Pro 
                325                 330                 335     


Lys Gly Tyr Tyr Ala Asn Phe Cys Ser Gly Pro Cys Pro Tyr Leu Arg 
            340                 345                 350         


Ser Ala Asp Thr Thr His Ser Thr Val Leu Gly Leu Tyr Asn Thr Leu 
        355                 360                 365             


Asn Pro Glu Ala Ser Ala Ser Pro Cys Cys Val Pro Gln Asp Leu Glu 
    370                 375                 380                 


Pro Leu Thr Ile Leu Tyr Tyr Val Gly Arg Thr Pro Lys Val Glu Gln 
385                 390                 395                 400 


Leu Ser Asn Met Val Val Lys Ser Cys Lys Cys Ser 
                405                 410         


<210>  79
<211>  5605
<212>  DNA
<213>  Homo sapiens

<400>  79
gttgcgagcg ctgcacaaca acaaaaggac ttggactggc cggcctgggc gcagcgaccc       60

gagggctgga gccggccccg cgcctgccgt ctgggtacct gaacgaggtg cagcgcagcc      120

cggccccacc gcagctacct cagcagtccc gccccgcccg cgtccttccc cgccgagccg      180

gcggccgctc ccttccccgc gcagccccgc acggcccggg cccacgtaca atgactcttc      240

ttgcttttca cctaagttga ataagcaccc tgtgcacttt aatctcctgt cggtaccatt      300

gggccaacta aagacaaggt tttgaaatct cagctataaa agacatccag ccaaactctc      360

agtcttgcct taacaatgtt ccagaggctg aataaaatgt ttgtgggtga agtcagttct      420

tcctccaacc aagaaccaga attcaatgag aaagaagatg atgaatggat tcttgttgac      480

ttcatagata cttgcactgg tttctcagca gaagaagaag aagaagagga ggacatcagt      540

gaagagtcac ctactgagca cccttcagtc ttttcctgtt taccggcatc tcttgagtgc      600

ttggctgata caagtgattc ctgctttctc cagtttgagt catgtccaat ggaggagagc      660

tggtttatca ccccaccccc atgttttact gcaggtggat taaccactat caaggtggaa      720

acaagtccta tggaaaacct tctcattgaa catcccagca tgtctgtcta tgctgtgcat      780

aactcctgcc ctggtctcag tgaggccacc cgtgggactg atgaattaca tagcccaagt      840

agtcccagag tggaagctca aaatgaaatg gggcagcata ttcattgtta tgttgcagct      900

cttgctgctc atacaacttt tctggaacaa cccaagagct ttcgcccttc ccagtggata      960

aaagaacaca gtgaaagaca gcctcttaac agaaatagcc ttcgtcgcca aaatcttacc     1020

agggattgcc accctcggca agtcaagcac aatggctggg ttgttcatca gccctgcccg     1080

cgtcagtaca attactaata gtttcaagtt ttgttggttg gtttctcttg gtttgtgctt     1140

acatgtatgg atgtgtgtat atgtacagtg aaaatgttgt ctctttacaa ccaattgata     1200

accaatcaca tagttttatc agtgtattta gacactatct tgaaaatcag atttatatgc     1260

tgtgtatcac ataatgcctt gcctttaaca tttacttttt ttgtacactt tttcagatta     1320

tttctggaaa catatcaata taattacagt gtttgggggt gtctttaaat atattaggtt     1380

atacattagt cagcatttta aagacatttc ttcccaagta cgagaatagg catctttcat     1440

tttcatttta ttttgtatta cttaatcttt taagcaagca aaaatttatt ctcagggtca     1500

gctgtacact ttattgacca gtacttgata atctctctgt atatgatgaa tacattttta     1560

cacactaaca ttagcattaa caggtgatag ttgccatgga tataatggaa ttatggctgg     1620

actttctttt gaaagaaaac ttgatgtatt ctgtgtgtat ggtttttccc cagattagtc     1680

atacagttca tttggaattc aggtacatta agctttagtg aagagtgcat gcagtaattc     1740

caatgtgact gcatgacgtg gtacagacat tacaggtgtt gtagacagag gcacttgtct     1800

cgtgcagagg gattaaatta gacctgtgag attatatttg gaaaaattca tgtctgtaac     1860

taacccatta gtgcagtatt taatttgtta ctattccttc ccgccaattc tgtccactcc     1920

tcacctcgca tcagctataa atttggaagt acttgtccag gcactcaagt gacttcatat     1980

ttctctctgc ccatgggaaa agagataggc tttatatttc cacagagtga aaaatcctct     2040

gtcatggagc ctgtcctgcc aagtggcaag agtgtgggga ctgtctggtg atgatgtctt     2100

tcatggcatc tgagtgaaga gtgacaggtt ggctcaactt ttttcttttt ttttttttaa     2160

ttgccttgta ttgtaagtat tcttccctgc agtccaagtg acttttcatt ttttgtttta     2220

acttcaggca aaatctttaa ccactctggc ctctgtttcc cccaccaacg gggagcagtg     2280

acatttacct ccctcacaga gtcactgtga ggattctata ctgatttgaa gtggagctgt     2340

tcagaactga accttgtagg aaattccaag ggcctttcta ctgaatctgg tgatggggtg     2400

gggccgtggc actttctctg ccacagctgt tcttcacagt gttggtgcta atgaggccag     2460

ggtgcagggt tcgattcaca cgtaggccag ttaacttaga gaaaatctat ttccttacct     2520

ctagccagtc acttcctttt tccgcagttg tgatgggttt tgctgagcca tccactctga     2580

ctgatttcct ctgaagtaaa catatttaca atccaaagca attctactga cagaagtgtt     2640

gccttcataa tcaaacagct tgtttttcca tctcctctgc aaccctaatt aaatgagtac     2700

aggtctacaa aatgttttca aggagaaaag cagcatatcc ttaagtgaag tattatattt     2760

ttcaataacc ctgtagtggc ttgatgcagg gaaccctggg ggactttcag cgaagagctg     2820

tgctcttttc tgactagatt agagcgtttg gagtggaaga cgtcaaatgt gtagtgagat     2880

ggaggtttta cattgttctt ctactggctg tgatgaagtg ccagaatgtc tctttagaac     2940

aagagttaga ttcccccttt ctccttattg ccccttccgt tttgacttcc cctttattta     3000

tttgttgtct aattaggggc caagtctgta aagttttgtc aaagtgagtt agaagttgtt     3060

ttctcttact atttgtgttt accagagttg ggagataaga tagtttccat gaaggtgtgt     3120

atgttttata cgatgtttgt tatagggcca tgcattggta acttgaaaat agaccagctt     3180

aatgtcttca ggatgtaaaa ctctgaatac acggcgtctc tttttcatac attgcatgta     3240

agttgttagt acctcacaag ctacagaagt tcagccatga gattttgttt ggcaacatga     3300

acagatttgt gtataactgc aatggccttt ttttccagat ttccttattg actttttgtt     3360

tgccttacct ggggctagtt ttttatgctt tgtacctaga aaacaaaaaa ttacattcgt     3420

tgggcttttt ttcaaggttg ggattaccac accacctgga atatcatact gtggtttctg     3480

cctaaaattg gcacatgtaa gtattgaaga aaatggttat ataattcagt tgaaactctt     3540

ggttattaga tgttaggcat ctcctgtatg taagacacaa ggccaaccac aacacagaac     3600

gatgttgacc tgttaagtat tctctgaaac atggccaaaa tgcattttat gagctttttt     3660

ttttgctatt gtaaatatta gtggtttaca atgcgcttta gacatatttc tttaaaatgc     3720

aagcagtgag aaataagacc tctctgaatt agtagctcta aactgttaac atagaatgtt     3780

acttggaaaa agtctggaat atgtggtgta cacaagcagt gcttcgtgaa tgagtttctt     3840

agcttttata gtgcgccatg tttctcaaag tttgtttttg ttgacaaaac attttataat     3900

atatatctta tgtttatttt ttttctcaac taattgtgta ctgcactgta aggtgaaaat     3960

tagccatcca ttatttatct tctgtggcaa tgcatttata tggttgattg ggtggggaat     4020

tttttgcaga aagatgcaaa gtgattgggt tttcgacttc ctatcgcagg gagcttttaa     4080

gaaatattaa tttcctatac atttttccaa tccccatgca aactgttcct gtttacatac     4140

cttctctgtt gtatcagtac tttgagtgag aagacagttt atttaaaact tgagcaggct     4200

gttcagcatt gtttctgctt ctgaaatctg tatagtacac tggtttgtaa tcattatgtc     4260

ttcattgaaa tccttgctac ttctcttcct cctcaatgaa atacattata tattatcttt     4320

atgtactctt aagaaaaacg agcaaggaag agtatcttca ttattctcat tttctctgag     4380

ttggaaacaa aaacatgaag gactccaact agaagacaga tatttacatt taaatagatt     4440

agtgggaaaa ctttaagagt ttccacatat tagttttcat tttttgagtc aagagactgc     4500

tccttgtact gggagacact agtagtatat gtttgtaatg ttactttaaa attatctttt     4560

tattttataa ggcccataaa tactggttaa actctgttaa aagtgggcct tctatcttgg     4620

atggtttcac tgccatcagc catgctgata tattagaaat ggcatcccta tctacttact     4680

ttaatgctta aaattataca taaaatgctt tatttagaaa acctacatga tacagtggtg     4740

tcagccttgc catgtatcag tttcacttga aatttgagac caattaaatt tcaactgttt     4800

agggtggaga aagaggtact ggaaaacatg cagatgagga tatcttttat gtgcaacagt     4860

atcctttgca tgggaggaga gttactcttg aaaggcaggc agcttaagtg gacaatgttt     4920

tgtatatagt tgagaatttt acgacacttt taaaaattgt gtaattgtta aatgtccagt     4980

tttgctctgt tttgcctgaa gttttagtat ttgttttcta ggtggacctc tgaaaaccaa     5040

accagtacct ggggaggtta gatgtgtgtt tcaggcttgg agtgtatgag tggttttgct     5100

tgtattttcc tccagagatt ttgaacttta ataattgcgt gtgttttttt tttttttaag     5160

tggctttgtt tttttttctc aagtaaaatt gtgaacatat ttcctttata ggggcagggc     5220

atgagttagg gagactgaag agtattgtag actgtacatg tgccttctta atgtgtttct     5280

cgacacattt tttttcagta acttgaaaat tcaaaaggga catttggtta ggttactgta     5340

catcaatcta tgcataaatg gcagcttgtt ttcttgagcc acggtctaaa ttttgttttt     5400

atagaaattt tttatactga ttggttcata gatggtcagt tttgtacaca gactgaacaa     5460

tacagcactt tgccaaaaat gagtgtagca ttgtttaaac attgtgtgtt aacacctgtt     5520

ctttgtaatt gggttgtggt gcattttgca ctacctggag ttacagtttt caatctgtca     5580

gtaaataaag tgtcctttaa cttca                                           5605


<210>  80
<211>  240
<212>  PRT
<213>  Homo sapiens

<400>  80

Met Phe Gln Arg Leu Asn Lys Met Phe Val Gly Glu Val Ser Ser Ser 
1               5                   10                  15      


Ser Asn Gln Glu Pro Glu Phe Asn Glu Lys Glu Asp Asp Glu Trp Ile 
            20                  25                  30          


Leu Val Asp Phe Ile Asp Thr Cys Thr Gly Phe Ser Ala Glu Glu Glu 
        35                  40                  45              


Glu Glu Glu Glu Asp Ile Ser Glu Glu Ser Pro Thr Glu His Pro Ser 
    50                  55                  60                  


Val Phe Ser Cys Leu Pro Ala Ser Leu Glu Cys Leu Ala Asp Thr Ser 
65                  70                  75                  80  


Asp Ser Cys Phe Leu Gln Phe Glu Ser Cys Pro Met Glu Glu Ser Trp 
                85                  90                  95      


Phe Ile Thr Pro Pro Pro Cys Phe Thr Ala Gly Gly Leu Thr Thr Ile 
            100                 105                 110         


Lys Val Glu Thr Ser Pro Met Glu Asn Leu Leu Ile Glu His Pro Ser 
        115                 120                 125             


Met Ser Val Tyr Ala Val His Asn Ser Cys Pro Gly Leu Ser Glu Ala 
    130                 135                 140                 


Thr Arg Gly Thr Asp Glu Leu His Ser Pro Ser Ser Pro Arg Val Glu 
145                 150                 155                 160 


Ala Gln Asn Glu Met Gly Gln His Ile His Cys Tyr Val Ala Ala Leu 
                165                 170                 175     


Ala Ala His Thr Thr Phe Leu Glu Gln Pro Lys Ser Phe Arg Pro Ser 
            180                 185                 190         


Gln Trp Ile Lys Glu His Ser Glu Arg Gln Pro Leu Asn Arg Asn Ser 
        195                 200                 205             


Leu Arg Arg Gln Asn Leu Thr Arg Asp Cys His Pro Arg Gln Val Lys 
    210                 215                 220                 


His Asn Gly Trp Val Val His Gln Pro Cys Pro Arg Gln Tyr Asn Tyr 
225                 230                 235                 240 


<210>  81
<211>  4127
<212>  DNA
<213>  Homo sapiens

<400>  81
gcacagactc aaagccccgc gggcgagctc agcagcccgg agcgaccgcg gccccgccgc       60

ctcccccgcg agtcccggcg atgcggcccg gcctgtgagc ggccggcgac cctgggacgc      120

cccgccgcac aactacctca acgccgtgcc gcccccctcc cgcccccagg gaatctctgg      180

agattggttc accttttgtg gtcctgaccc cttctgtcct cactgtacct tgaagtccta      240

gagtccaata aaatcgctgc ctcccagctg tttggatcac agagaggttt ttgcactgcc      300

atagggcgcc cccgtgaggc gcttcgcccc ccaccatgtt ccagcgcctc tccagcctct      360

tcttcagcac cccctcgccc cccgaagacc ccgactgccc ccgcgccttc gtgtcggagg      420

aggatgaagt ggacggctgg ctcatcattg acctgccgga cagctacgcg gctccaccca      480

gccccggggc cgcccctgcc cccgcgggcc gccctccgcc cgcgccctcc ttgatggacg      540

agagctggtt tgttacccct cccgcctgtt ttacggcaga ggggcctgga ctcggtcccg      600

cccgcctcca gagcagtccc ctggaggacc tcctcatcga gcaccccagc atgtccgttt      660

acgtcaccgg cagcaccata gtgctagagc ccgggtcccc ttccccgctc ccggacgcgg      720

ccctgcctga cggcgacctc agcgaagggg aattgacgcc cgcccgccgc gagccgcggg      780

ccgcgcgcca cgccgctcct ctcccagcgc gggcggcgct gctggagaag gcgggccagg      840

tgcggcggct gcagcgggcc cggcagcggg cagagcgcca cgcgctgagc gccaaggcgg      900

tgcagcggca gaaccgagcc cgcgagagcc gtccgcgccg gtccaagaac cagagcagct      960

tcatctacca gccgtgccag cgccagttca actactgagc gtccaccggc cgcgccacga     1020

accccttgcc gatcccgatc cctgtcgggc tcctccgact cctcgggctg gacaccgaaa     1080

cctcccttct taaagcgtgt gaggttgggt gatagccgtt ccttccccga caccctcaat     1140

ttccccatct ctgatcctct aatctgcctc tgaacccatt cacccttcac cctcactcct     1200

ggtccccata cccagcatct aatcatccat gccccctact cctggcccct ccatcctttc     1260

ttctctggtc cccatccctg tctctccctt tcacccttgc cctccagtcc tctacctctg     1320

gcctgcccct atttctgaaa gcttcttcca gtccctgatc tggctcattc cccaccttca     1380

actcccacct tacatgtctc acactatccc atggttggca ttacactcac tcctgttccc     1440

ttattcttca ttcccagtaa ttccctacca aatggtgggg accctgagcc cagctctgac     1500

caggtagagc ctgtgcagcc tgggctgctg tcattgccct ccagtaaggg ctcagggttt     1560

tgcttttagt ctccccttcc ttctgccttg ggggcggtac tctgtggagc tgcttaggcc     1620

tggaaaggta cagtatgtag aagaggactg tgagacgtga gttagaggga gaagatggag     1680

ggaatctagg gaacgaggca gcctattgga gatgcggaca ggacagacac gttgagaagc     1740

tgcagggagc agggcaccaa gggagtgtgc actgtgcttg ctcagagagg ccaaaccctg     1800

ctcccaggct gaagcctgga gtctgccccc acttcccttt tctataatcc acccttctgc     1860

aggccctgaa atctgaaggg cttagttagt accttgccac tctaccccca acacgtcacc     1920

cgagtagaag ctgggcaagg ccctaccatc ctggccgtct gttcacaagc ccaaggtgct     1980

agaactagct taggagacat gcaggccaca gggcttctag gcagggaaag ggcacacacc     2040

ctaggtcagc gtgcagagca gtgatgctgg aggacacacc atggggtgaa gccatcccaa     2100

ggctgacagc tcagtcttca ccttgcctct ggccttgtat ttcacaccct gctcagtatg     2160

gctagccagc agtcctgagt aggagtccag gactcccact gtctcaatct gcaaattgtt     2220

cctatccagg ttcagggcct tcagggggcc tcttttcatt ttctcccaca ggcctctctt     2280

tctttctagg ttgctgggga gaaatgggta ccctatgatc cccctcccct tctcctccag     2340

taaatacctg gaagagggaa cctgaatccc tgggggagac agaaggggca ggggccacca     2400

gcctcccctt cttgtggtga gactgaattt tgggctcaga caccagcaac agcctcttgg     2460

gatgccctga gttgcttccc atttcctctt tctagccgtc cttttctagt gtgtgctcac     2520

tcttcctagg aacttttaag acttcttggt acctatgaac ataggtcctc ccctcacccc     2580

aactctaggt ttccaggcct cacagccaag ctgaagcttg gagaaaactc tgcattccca     2640

tgagggcaaa ggcagctgcc ctccctgacc ctatagcccc aggcctcatg gggggtatgt     2700

ggggaaggga tggggtatcc ccatggatgc tgggatgagg acagaggaag acctgatggg     2760

gtctcctatt ccagggaata agccaaatta acactaaaaa cggatcaaag ctcccacgcc     2820

agtccactag ggccccagta gttgacagcc ttgctcctct cccaagttct ccttcagaac     2880

ctagttgctt ttattcttcc agctaccact tgggcacttc acagccagcc tagggtcttc     2940

ggcacctcca agagctgaat ctccctccaa cccttcttgc ctactcctca ctgccagctg     3000

ggacctaggc tcagtcctgt gtggtgccca tgatccttct ggtgggggaa gagtttaagt     3060

tatagggcat ttggctcaaa ttttaaaagg ccttttgttt acctatattt ctggaggctc     3120

ctgtattcta gaacccaatc tctcacctgc ttggttgcaa ggctcatatt tttttgtacc     3180

tttcctatag attctgtagc atttgagtgt ggcaatattt taattgtgta tagatttcta     3240

agaaccaaca ctactcagtc tcctgctagt ctgactcctg aagcatcagc ccttgtcata     3300

ctgtattgac tgtgtacgtg cctttcacct tgagcatgct tcaggatttt tttttaaacc     3360

acagaacttg aatacatgag ggaaccagag ttcaaagtcc tatgcaacct taggaggggg     3420

ttagagagtc tgttttgatt gatgttttct gaggccctag aggagtttgt atcaatttgt     3480

gagtattaat gtcagtacta ccagcacttt gccaaaactg tcagagggac ccgtttctag     3540

agtgagtccc agttacatca aacagtgact tccagttatt ccccagtaag tctgagtggt     3600

tccttcaagc tgggtgtctt tccagccttt gccagtctag ccccagcagg gcaccgtgta     3660

tgaatgcagt ttggtgctgt tttagagtat gcctgctccc cagccccctg cctggaaccc     3720

tctgagcaac ttgctctgac ctataatgtc ttaggtgcaa cacggacccc accagagctc     3780

ttggataccc ccctagatcc atgtggcttt atgtgagggg actgaatgca gacacaccat     3840

agcccccttc tactactttc cctctcgccc tgccacctag ttccacatgg aaccaacaag     3900

ttgagtgcat ccctgttggg tgttttgtgt tgagactggc tgaaatgagg agactttgac     3960

catgtgacgt gtcaacagac tcaaggagac aaccacctca actgggtcat gtggcatgcc     4020

tgtgtatgtg tgtaacagaa ttctgattgt tagactgtaa tgctattcct ctatgggaga     4080

aaaaaattaa tataaagaaa aacaaataaa aatatattta aagcaca                   4127


<210>  82
<211>  220
<212>  PRT
<213>  Homo sapiens

<400>  82

Met Phe Gln Arg Leu Ser Ser Leu Phe Phe Ser Thr Pro Ser Pro Pro 
1               5                   10                  15      


Glu Asp Pro Asp Cys Pro Arg Ala Phe Val Ser Glu Glu Asp Glu Val 
            20                  25                  30          


Asp Gly Trp Leu Ile Ile Asp Leu Pro Asp Ser Tyr Ala Ala Pro Pro 
        35                  40                  45              


Ser Pro Gly Ala Ala Pro Ala Pro Ala Gly Arg Pro Pro Pro Ala Pro 
    50                  55                  60                  


Ser Leu Met Asp Glu Ser Trp Phe Val Thr Pro Pro Ala Cys Phe Thr 
65                  70                  75                  80  


Ala Glu Gly Pro Gly Leu Gly Pro Ala Arg Leu Gln Ser Ser Pro Leu 
                85                  90                  95      


Glu Asp Leu Leu Ile Glu His Pro Ser Met Ser Val Tyr Val Thr Gly 
            100                 105                 110         


Ser Thr Ile Val Leu Glu Pro Gly Ser Pro Ser Pro Leu Pro Asp Ala 
        115                 120                 125             


Ala Leu Pro Asp Gly Asp Leu Ser Glu Gly Glu Leu Thr Pro Ala Arg 
    130                 135                 140                 


Arg Glu Pro Arg Ala Ala Arg His Ala Ala Pro Leu Pro Ala Arg Ala 
145                 150                 155                 160 


Ala Leu Leu Glu Lys Ala Gly Gln Val Arg Arg Leu Gln Arg Ala Arg 
                165                 170                 175     


Gln Arg Ala Glu Arg His Ala Leu Ser Ala Lys Ala Val Gln Arg Gln 
            180                 185                 190         


Asn Arg Ala Arg Glu Ser Arg Pro Arg Arg Ser Lys Asn Gln Ser Ser 
        195                 200                 205             


Phe Ile Tyr Gln Pro Cys Gln Arg Gln Phe Asn Tyr 
    210                 215                 220 


<210>  83
<211>  2199
<212>  DNA
<213>  Homo sapiens

<400>  83
agacggtggc cgagcggggg accgggaagc atggcccggg ggtcggcggt tgcctgggcg       60

gcgctcgggc cgttgttgtg gggctgcgcg ctggggctgc agggcgggat gctgtacccc      120

caggagagcc cgtcgcggga gtgcaaggag ctggacggcc tctggagctt ccgcgccgac      180

ttctctgaca accgacgccg gggcttcgag gagcagtggt accggcggcc gctgtgggag      240

tcaggcccca ccgtggacat gccagttccc tccagcttca atgacatcag ccaggactgg      300

cgtctgcggc attttgtcgg ctgggtgtgg tacgaacggg aggtgatcct gccggagcga      360

tggacccagg acctgcgcac aagagtggtg ctgaggattg gcagtgccca ttcctatgcc      420

atcgtgtggg tgaatggggt cgacacgcta gagcatgagg ggggctacct ccccttcgag      480

gccgacatca gcaacctggt ccaggtgggg cccctgccct cccggctccg aatcactatc      540

gccatcaaca acacactcac ccccaccacc ctgccaccag ggaccatcca atacctgact      600

gacacctcca agtatcccaa gggttacttt gtccagaaca catattttga ctttttcaac      660

tacgctggac tgcagcggtc tgtacttctg tacacgacac ccaccaccta catcgatgac      720

atcaccgtca ccaccagcgt ggagcaagac agtgggctgg tgaattacca gatctctgtc      780

aagggcagta acctgttcaa gttggaagtg cgtcttttgg atgcagaaaa caaagtcgtg      840

gcgaatggga ctgggaccca gggccaactt aaggtgccag gtgtcagcct ctggtggccg      900

tacctgatgc acgaacgccc tgcctatctg tattcattgg aggtgcagct gactgcacag      960

acgtcactgg ggcctgtgtc tgacttctac acactccctg tggggatccg cactgtggct     1020

gtcaccaaga gccagttcct catcaatggg aaacctttct atttccacgg tgtcaacaag     1080

catgaggatg cggacatccg agggaagggc ttcgactggc cgctgctggt gaaggacttc     1140

aacctgcttc gctggcttgg tgccaacgct ttccgtacca gccactaccc ctatgcagag     1200

gaagtgatgc agatgtgtga ccgctatggg attgtggtca tcgatgagtg tcccggcgtg     1260

ggcctggcgc tgccgcagtt cttcaacaac gtttctctgc atcaccacat gcaggtgatg     1320

gaagaagtgg tgcgtaggga caagaaccac cccgcggtcg tgatgtggtc tgtggccaac     1380

gagcctgcgt cccacctaga atctgctggc tactacttga agatggtgat cgctcacacc     1440

aaatccttgg acccctcccg gcctgtgacc tttgtgagca actctaacta tgcagcagac     1500

aagggggctc cgtatgtgga tgtgatctgt ttgaacagct actactcttg gtatcacgac     1560

tacgggcacc tggagttgat tcagctgcag ctggccaccc agtttgagaa ctggtataag     1620

aagtatcaga agcccattat tcagagcgag tatggagcag aaacgattgc agggtttcac     1680

caggatccac ctctgatgtt cactgaagag taccagaaaa gtctgctaga gcagtaccat     1740

ctgggtctgg atcaaaaacg cagaaaatac gtggttggag agctcatttg gaattttgcc     1800

gatttcatga ctgaacagtc accgacgaga gtgctgggga ataaaaaggg gatcttcact     1860

cggcagagac aaccaaaaag tgcagcgttc cttttgcgag agagatactg gaagattgcc     1920

aatgaaacca ggtatcccca ctcagtagcc aagtcacaat gtttggaaaa cagcctgttt     1980

acttgagcaa gactgatacc acctgcgtgt cccttcctcc ccgagtcagg gcgacttcca     2040

cagcagcaga acaagtgcct cctggactgt tcacggcaga ccagaacgtt tctggcctgg     2100

gttttgtggt catctattct agcagggaac actaaaggtg gaaataaaag attttctatt     2160

atggaaataa agagttggca tgaaagtggc tactgaaaa                            2199


<210>  84
<211>  651
<212>  PRT
<213>  Homo sapiens

<400>  84

Met Ala Arg Gly Ser Ala Val Ala Trp Ala Ala Leu Gly Pro Leu Leu 
1               5                   10                  15      


Trp Gly Cys Ala Leu Gly Leu Gln Gly Gly Met Leu Tyr Pro Gln Glu 
            20                  25                  30          


Ser Pro Ser Arg Glu Cys Lys Glu Leu Asp Gly Leu Trp Ser Phe Arg 
        35                  40                  45              


Ala Asp Phe Ser Asp Asn Arg Arg Arg Gly Phe Glu Glu Gln Trp Tyr 
    50                  55                  60                  


Arg Arg Pro Leu Trp Glu Ser Gly Pro Thr Val Asp Met Pro Val Pro 
65                  70                  75                  80  


Ser Ser Phe Asn Asp Ile Ser Gln Asp Trp Arg Leu Arg His Phe Val 
                85                  90                  95      


Gly Trp Val Trp Tyr Glu Arg Glu Val Ile Leu Pro Glu Arg Trp Thr 
            100                 105                 110         


Gln Asp Leu Arg Thr Arg Val Val Leu Arg Ile Gly Ser Ala His Ser 
        115                 120                 125             


Tyr Ala Ile Val Trp Val Asn Gly Val Asp Thr Leu Glu His Glu Gly 
    130                 135                 140                 


Gly Tyr Leu Pro Phe Glu Ala Asp Ile Ser Asn Leu Val Gln Val Gly 
145                 150                 155                 160 


Pro Leu Pro Ser Arg Leu Arg Ile Thr Ile Ala Ile Asn Asn Thr Leu 
                165                 170                 175     


Thr Pro Thr Thr Leu Pro Pro Gly Thr Ile Gln Tyr Leu Thr Asp Thr 
            180                 185                 190         


Ser Lys Tyr Pro Lys Gly Tyr Phe Val Gln Asn Thr Tyr Phe Asp Phe 
        195                 200                 205             


Phe Asn Tyr Ala Gly Leu Gln Arg Ser Val Leu Leu Tyr Thr Thr Pro 
    210                 215                 220                 


Thr Thr Tyr Ile Asp Asp Ile Thr Val Thr Thr Ser Val Glu Gln Asp 
225                 230                 235                 240 


Ser Gly Leu Val Asn Tyr Gln Ile Ser Val Lys Gly Ser Asn Leu Phe 
                245                 250                 255     


Lys Leu Glu Val Arg Leu Leu Asp Ala Glu Asn Lys Val Val Ala Asn 
            260                 265                 270         


Gly Thr Gly Thr Gln Gly Gln Leu Lys Val Pro Gly Val Ser Leu Trp 
        275                 280                 285             


Trp Pro Tyr Leu Met His Glu Arg Pro Ala Tyr Leu Tyr Ser Leu Glu 
    290                 295                 300                 


Val Gln Leu Thr Ala Gln Thr Ser Leu Gly Pro Val Ser Asp Phe Tyr 
305                 310                 315                 320 


Thr Leu Pro Val Gly Ile Arg Thr Val Ala Val Thr Lys Ser Gln Phe 
                325                 330                 335     


Leu Ile Asn Gly Lys Pro Phe Tyr Phe His Gly Val Asn Lys His Glu 
            340                 345                 350         


Asp Ala Asp Ile Arg Gly Lys Gly Phe Asp Trp Pro Leu Leu Val Lys 
        355                 360                 365             


Asp Phe Asn Leu Leu Arg Trp Leu Gly Ala Asn Ala Phe Arg Thr Ser 
    370                 375                 380                 


His Tyr Pro Tyr Ala Glu Glu Val Met Gln Met Cys Asp Arg Tyr Gly 
385                 390                 395                 400 


Ile Val Val Ile Asp Glu Cys Pro Gly Val Gly Leu Ala Leu Pro Gln 
                405                 410                 415     


Phe Phe Asn Asn Val Ser Leu His His His Met Gln Val Met Glu Glu 
            420                 425                 430         


Val Val Arg Arg Asp Lys Asn His Pro Ala Val Val Met Trp Ser Val 
        435                 440                 445             


Ala Asn Glu Pro Ala Ser His Leu Glu Ser Ala Gly Tyr Tyr Leu Lys 
    450                 455                 460                 


Met Val Ile Ala His Thr Lys Ser Leu Asp Pro Ser Arg Pro Val Thr 
465                 470                 475                 480 


Phe Val Ser Asn Ser Asn Tyr Ala Ala Asp Lys Gly Ala Pro Tyr Val 
                485                 490                 495     


Asp Val Ile Cys Leu Asn Ser Tyr Tyr Ser Trp Tyr His Asp Tyr Gly 
            500                 505                 510         


His Leu Glu Leu Ile Gln Leu Gln Leu Ala Thr Gln Phe Glu Asn Trp 
        515                 520                 525             


Tyr Lys Lys Tyr Gln Lys Pro Ile Ile Gln Ser Glu Tyr Gly Ala Glu 
    530                 535                 540                 


Thr Ile Ala Gly Phe His Gln Asp Pro Pro Leu Met Phe Thr Glu Glu 
545                 550                 555                 560 


Tyr Gln Lys Ser Leu Leu Glu Gln Tyr His Leu Gly Leu Asp Gln Lys 
                565                 570                 575     


Arg Arg Lys Tyr Val Val Gly Glu Leu Ile Trp Asn Phe Ala Asp Phe 
            580                 585                 590         


Met Thr Glu Gln Ser Pro Thr Arg Val Leu Gly Asn Lys Lys Gly Ile 
        595                 600                 605             


Phe Thr Arg Gln Arg Gln Pro Lys Ser Ala Ala Phe Leu Leu Arg Glu 
    610                 615                 620                 


Arg Tyr Trp Lys Ile Ala Asn Glu Thr Arg Tyr Pro His Ser Val Ala 
625                 630                 635                 640 


Lys Ser Gln Cys Leu Glu Asn Ser Leu Phe Thr 
                645                 650     


<210>  85
<211>  2237
<212>  DNA
<213>  Homo sapiens

<400>  85
gttttgcaga cgccaccgcc gaggaaaacc gtgtactatt agccatggtc aaccccaccg       60

tgttcttcga cattgccgtc gacggcgagc ccttgggccg cgtctccttt gagctgtttg      120

cagacaaggt cccaaagaca gcagaaaatt ttcgtgctct gagcactgga gagaaaggat      180

ttggttataa gggttcctgc tttcacagaa ttattccagg gtttatgtgt cagggtggtg      240

acttcacacg ccataatggc actggtggca agtccatcta tggggagaaa tttgaagatg      300

agaacttcat cctaaagcat acgggtcctg gcatcttgtc catggcaaat gctggaccca      360

acacaaatgg ttcccagttt ttcatctgca ctgccaagac tgagtggttg gatggcaagc      420

atgtggtgtt tggcaaagtg aaagaaggca tgaatattgt ggaggccatg gagcgctttg      480

ggtccaggaa tggcaagacc agcaagaaga tcaccattgc tgactgtgga caactcgaat      540

aagtttgact tgtgttttat cttaaccacc agatcattcc ttctgtagct caggagagca      600

cccctccacc ccatttgctc gcagtatcct agaatctttg tgctctcgct gcagttccct      660

ttgggttcca tgttttcctt gttccctccc atgcctagct ggattgcaga gttaagttta      720

tgattatgaa ataaaaacta aataacaatt gtcctcgttt gagttaagag tgttgatgta      780

ggctttattt taagcagtaa tgggttactt ctgaaacatc acttgtttgc ttaattctac      840

acagtactta gatttttttt actttccagt cccaggaagt gtcaatgttt gttgagtgga      900

atattgaaaa tgtaggcagc aactgggcat ggtggctcac tgtctgtaat gtattacctg      960

aggcagaaga ccacctgagg gtaggagtca agatcagcct gggcaacata gtgagacgct     1020

gtctctacaa aaaataatta gcctggcctg gtggtgcatg cctagtccta gctgatctgg     1080

aggctgacgt gggaggattg cttgagccta gagtgagcta ttatcatgcc actgtacagc     1140

ctgggtgttc acagatcttg tgtctcaaag gtaggcagag gcaggaaaag caaggagcca     1200

gaattaagag gttgggtcag tctgcagtga gttcatgcat ttagaggtgt tcttcaagat     1260

gactaatgtc aaaaattgag acatctgttg cggttttttt tttttttttt tcccctggaa     1320

tgcagtggcg tgatctcagc tcactgcagc ctccgcctcc tgggttcaag tgattctagt     1380

gcctcagcct cctgagtagc tgggataatg ggcgtgtgcc accatgccca gctaattttt     1440

gtatttttag tatagatggg gtttcatcat tttgaccagg ctggtctcaa actcttgacc     1500

tcagctgatg cgcctgcctt ggcctcccaa actgctgaga ttacagatgt gagccaccgc     1560

accctacctc attttctgta acaaagctaa gcttgaacac tgttgatgtt cttgagggaa     1620

gcatattggg ctttaggctg taggtcaagt ttatacatct taattatggt ggaattccta     1680

tgtagagtct aaaaagccag gtacttggtg ctacagtcag tctccctgca gagggttaag     1740

gcgcagacta cctgcagtga ggaggtactg cttgtagcat atagagcctc tccctagctt     1800

tggttatgga ggctttgagg ttttgcaaac ctgaccaatt taagccataa gatctggtca     1860

aagggatacc cttcccacta aggacttggt ttctcaggaa attatatgta cagtgcttgc     1920

tggcagttag atgtcaggac aatctaagct gagaaaaccc cttctctgcc caccttaaca     1980

gacctctagg gttcttaacc cagcaatcaa gtttgcctat cctagaggtg gcggatttga     2040

tcatttggtg tgttgggcaa tttttgtttt actgtctggt tccttctgcg tgaattacca     2100

ccaccaccac ttgtgcatct cagtcttgtg tgttgtctgg ttacgtattc cctgggtgat     2160

accattcaat gtcttaatgt acttgtggct cagacctgag tgcaaggtgg aaataaacat     2220

caaacatctt ttcatta                                                    2237


<210>  86
<211>  165
<212>  PRT
<213>  Homo sapiens

<400>  86

Met Val Asn Pro Thr Val Phe Phe Asp Ile Ala Val Asp Gly Glu Pro 
1               5                   10                  15      


Leu Gly Arg Val Ser Phe Glu Leu Phe Ala Asp Lys Val Pro Lys Thr 
            20                  25                  30          


Ala Glu Asn Phe Arg Ala Leu Ser Thr Gly Glu Lys Gly Phe Gly Tyr 
        35                  40                  45              


Lys Gly Ser Cys Phe His Arg Ile Ile Pro Gly Phe Met Cys Gln Gly 
    50                  55                  60                  


Gly Asp Phe Thr Arg His Asn Gly Thr Gly Gly Lys Ser Ile Tyr Gly 
65                  70                  75                  80  


Glu Lys Phe Glu Asp Glu Asn Phe Ile Leu Lys His Thr Gly Pro Gly 
                85                  90                  95      


Ile Leu Ser Met Ala Asn Ala Gly Pro Asn Thr Asn Gly Ser Gln Phe 
            100                 105                 110         


Phe Ile Cys Thr Ala Lys Thr Glu Trp Leu Asp Gly Lys His Val Val 
        115                 120                 125             


Phe Gly Lys Val Lys Glu Gly Met Asn Ile Val Glu Ala Met Glu Arg 
    130                 135                 140                 


Phe Gly Ser Arg Asn Gly Lys Thr Ser Lys Lys Ile Thr Ile Ala Asp 
145                 150                 155                 160 


Cys Gly Gln Leu Glu 
                165 


<210>  87
<211>  2193
<212>  DNA
<213>  Homo sapiens

<400>  87
agttccgtcg cagccgggat ttgggtcgca gttcttgttt gtggatcgct gtgatcgtca       60

cttgacaatg cagatcttcg tgaagactct gactggtaag accatcaccc tcgaggttga      120

gcccagtgac accatcgaga atgtcaaggc aaagatccaa gataaggaag gcatccctcc      180

tgaccagcag aggctgatct ttgctggaaa acagctggaa gatgggcgca ccctgtctga      240

ctacaacatc cagaaagagt ccaccctgca cctggtgctc cgtctcagag gtgggatgca      300

aatcttcgtg aagacactca ctggcaagac catcaccctt gaggtcgagc ccagtgacac      360

catcgagaac gtcaaagcaa agatccagga caaggaaggc attcctcctg accagcagag      420

gttgatcttt gccggaaagc agctggaaga tgggcgcacc ctgtctgact acaacatcca      480

gaaagagtct accctgcacc tggtgctccg tctcagaggt gggatgcaga tcttcgtgaa      540

gaccctgact ggtaagacca tcaccctcga ggtggagccc agtgacacca tcgagaatgt      600

caaggcaaag atccaagata aggaaggcat tcctcctgat cagcagaggt tgatctttgc      660

cggaaaacag ctggaagatg gtcgtaccct gtctgactac aacatccaga aagagtccac      720

cttgcacctg gtactccgtc tcagaggtgg gatgcaaatc ttcgtgaaga cactcactgg      780

caagaccatc acccttgagg tcgagcccag tgacactatc gagaacgtca aagcaaagat      840

ccaagacaag gaaggcattc ctcctgacca gcagaggttg atctttgccg gaaagcagct      900

ggaagatggg cgcaccctgt ctgactacaa catccagaaa gagtctaccc tgcacctggt      960

gctccgtctc agaggtggga tgcagatctt cgtgaagacc ctgactggta agaccatcac     1020

tctcgaagtg gagccgagtg acaccattga gaatgtcaag gcaaagatcc aagacaagga     1080

aggcatccct cctgaccagc agaggttgat ctttgccgga aaacagctgg aagatggtcg     1140

taccctgtct gactacaaca tccagaaaga gtccaccttg cacctggtgc tccgtctcag     1200

aggtgggatg cagatcttcg tgaagaccct gactggtaag accatcactc tcgaggtgga     1260

gccgagtgac accattgaga atgtcaaggc aaagatccaa gacaaggaag gcatccctcc     1320

tgaccagcag aggttgatct ttgctgggaa acagctggaa gatggacgca ccctgtctga     1380

ctacaacatc cagaaagagt ccaccctgca cctggtgctc cgtcttagag gtgggatgca     1440

gatcttcgtg aagaccctga ctggtaagac catcactctc gaagtggagc cgagtgacac     1500

cattgagaat gtcaaggcaa agatccaaga caaggaaggc atccctcctg accagcagag     1560

gttgatcttt gctgggaaac agctggaaga tggacgcacc ctgtctgact acaacatcca     1620

gaaagagtcc accctgcacc tggtgctccg tcttagaggt gggatgcaga tcttcgtgaa     1680

gaccctgact ggtaagacca tcactctcga agtggagccg agtgacacca ttgagaatgt     1740

caaggcaaag atccaagaca aggaaggcat ccctcctgac cagcagaggt tgatctttgc     1800

tgggaaacag ctggaagatg gacgcaccct gtctgactac aacatccaga aagagtccac     1860

cctgcacctg gtgctccgtc tcagaggtgg gatgcaaatc ttcgtgaaga ccctgactgg     1920

taagaccatc accctcgagg tggagcccag tgacaccatc gagaatgtca aggcaaagat     1980

ccaagataag gaaggcatcc ctcctgatca gcagaggttg atctttgctg ggaaacagct     2040

ggaagatgga cgcaccctgt ctgactacaa catccagaaa gagtccactc tgcacttggt     2100

cctgcgcttg agggggggtg tctaagtttc cccttttaag gtttcaacaa atttcattgc     2160

actttccttt caataaagtt gttgcattcc caa                                  2193


<210>  88
<211>  685
<212>  PRT
<213>  Homo sapiens

<400>  88

Met Gln Ile Phe Val Lys Thr Leu Thr Gly Lys Thr Ile Thr Leu Glu 
1               5                   10                  15      


Val Glu Pro Ser Asp Thr Ile Glu Asn Val Lys Ala Lys Ile Gln Asp 
            20                  25                  30          


Lys Glu Gly Ile Pro Pro Asp Gln Gln Arg Leu Ile Phe Ala Gly Lys 
        35                  40                  45              


Gln Leu Glu Asp Gly Arg Thr Leu Ser Asp Tyr Asn Ile Gln Lys Glu 
    50                  55                  60                  


Ser Thr Leu His Leu Val Leu Arg Leu Arg Gly Gly Met Gln Ile Phe 
65                  70                  75                  80  


Val Lys Thr Leu Thr Gly Lys Thr Ile Thr Leu Glu Val Glu Pro Ser 
                85                  90                  95      


Asp Thr Ile Glu Asn Val Lys Ala Lys Ile Gln Asp Lys Glu Gly Ile 
            100                 105                 110         


Pro Pro Asp Gln Gln Arg Leu Ile Phe Ala Gly Lys Gln Leu Glu Asp 
        115                 120                 125             


Gly Arg Thr Leu Ser Asp Tyr Asn Ile Gln Lys Glu Ser Thr Leu His 
    130                 135                 140                 


Leu Val Leu Arg Leu Arg Gly Gly Met Gln Ile Phe Val Lys Thr Leu 
145                 150                 155                 160 


Thr Gly Lys Thr Ile Thr Leu Glu Val Glu Pro Ser Asp Thr Ile Glu 
                165                 170                 175     


Asn Val Lys Ala Lys Ile Gln Asp Lys Glu Gly Ile Pro Pro Asp Gln 
            180                 185                 190         


Gln Arg Leu Ile Phe Ala Gly Lys Gln Leu Glu Asp Gly Arg Thr Leu 
        195                 200                 205             


Ser Asp Tyr Asn Ile Gln Lys Glu Ser Thr Leu His Leu Val Leu Arg 
    210                 215                 220                 


Leu Arg Gly Gly Met Gln Ile Phe Val Lys Thr Leu Thr Gly Lys Thr 
225                 230                 235                 240 


Ile Thr Leu Glu Val Glu Pro Ser Asp Thr Ile Glu Asn Val Lys Ala 
                245                 250                 255     


Lys Ile Gln Asp Lys Glu Gly Ile Pro Pro Asp Gln Gln Arg Leu Ile 
            260                 265                 270         


Phe Ala Gly Lys Gln Leu Glu Asp Gly Arg Thr Leu Ser Asp Tyr Asn 
        275                 280                 285             


Ile Gln Lys Glu Ser Thr Leu His Leu Val Leu Arg Leu Arg Gly Gly 
    290                 295                 300                 


Met Gln Ile Phe Val Lys Thr Leu Thr Gly Lys Thr Ile Thr Leu Glu 
305                 310                 315                 320 


Val Glu Pro Ser Asp Thr Ile Glu Asn Val Lys Ala Lys Ile Gln Asp 
                325                 330                 335     


Lys Glu Gly Ile Pro Pro Asp Gln Gln Arg Leu Ile Phe Ala Gly Lys 
            340                 345                 350         


Gln Leu Glu Asp Gly Arg Thr Leu Ser Asp Tyr Asn Ile Gln Lys Glu 
        355                 360                 365             


Ser Thr Leu His Leu Val Leu Arg Leu Arg Gly Gly Met Gln Ile Phe 
    370                 375                 380                 


Val Lys Thr Leu Thr Gly Lys Thr Ile Thr Leu Glu Val Glu Pro Ser 
385                 390                 395                 400 


Asp Thr Ile Glu Asn Val Lys Ala Lys Ile Gln Asp Lys Glu Gly Ile 
                405                 410                 415     


Pro Pro Asp Gln Gln Arg Leu Ile Phe Ala Gly Lys Gln Leu Glu Asp 
            420                 425                 430         


Gly Arg Thr Leu Ser Asp Tyr Asn Ile Gln Lys Glu Ser Thr Leu His 
        435                 440                 445             


Leu Val Leu Arg Leu Arg Gly Gly Met Gln Ile Phe Val Lys Thr Leu 
    450                 455                 460                 


Thr Gly Lys Thr Ile Thr Leu Glu Val Glu Pro Ser Asp Thr Ile Glu 
465                 470                 475                 480 


Asn Val Lys Ala Lys Ile Gln Asp Lys Glu Gly Ile Pro Pro Asp Gln 
                485                 490                 495     


Gln Arg Leu Ile Phe Ala Gly Lys Gln Leu Glu Asp Gly Arg Thr Leu 
            500                 505                 510         


Ser Asp Tyr Asn Ile Gln Lys Glu Ser Thr Leu His Leu Val Leu Arg 
        515                 520                 525             


Leu Arg Gly Gly Met Gln Ile Phe Val Lys Thr Leu Thr Gly Lys Thr 
    530                 535                 540                 


Ile Thr Leu Glu Val Glu Pro Ser Asp Thr Ile Glu Asn Val Lys Ala 
545                 550                 555                 560 


Lys Ile Gln Asp Lys Glu Gly Ile Pro Pro Asp Gln Gln Arg Leu Ile 
                565                 570                 575     


Phe Ala Gly Lys Gln Leu Glu Asp Gly Arg Thr Leu Ser Asp Tyr Asn 
            580                 585                 590         


Ile Gln Lys Glu Ser Thr Leu His Leu Val Leu Arg Leu Arg Gly Gly 
        595                 600                 605             


Met Gln Ile Phe Val Lys Thr Leu Thr Gly Lys Thr Ile Thr Leu Glu 
    610                 615                 620                 


Val Glu Pro Ser Asp Thr Ile Glu Asn Val Lys Ala Lys Ile Gln Asp 
625                 630                 635                 640 


Lys Glu Gly Ile Pro Pro Asp Gln Gln Arg Leu Ile Phe Ala Gly Lys 
                645                 650                 655     


Gln Leu Glu Asp Gly Arg Thr Leu Ser Asp Tyr Asn Ile Gln Lys Glu 
            660                 665                 670         


Ser Thr Leu His Leu Val Leu Arg Leu Arg Gly Gly Val 
        675                 680                 685 


<210>  89
<211>  2547
<212>  DNA
<213>  Homo sapiens

<400>  89
actgcagccc cgctcgactc cggcgtggtg cgcaggcgcg gtatcccccc tcccccgcca       60

gctcgacccc ggtgtggtgc gcaggcgcag tctgcgcagg gactggcggg actgcgcggc      120

ggcaacagca gacatgtcgg gggtccgggg cctgtcgcgg ctgctgagcg ctcggcgcct      180

ggcgctggcc aaggcgtggc caacagtgtt gcaaacagga acccgaggtt ttcacttcac      240

tgttgatggg aacaagaggg catctgctaa agtttcagat tccatttctg ctcagtatcc      300

agtagtggat catgaatttg atgcagtggt ggtaggcgct ggaggggcag gcttgcgagc      360

tgcatttggc ctttctgagg cagggtttaa tacagcatgt gttaccaagc tgtttcctac      420

caggtcacac actgttgcag cacagggagg aatcaatgct gctctgggga acatggagga      480

ggacaactgg aggtggcatt tctacgacac cgtgaagggc tccgactggc tgggggacca      540

ggatgccatc cactacatga cggagcaggc ccccgccgcc gtggtcgagc tagaaaatta      600

tggcatgccg tttagcagaa ctgaagatgg gaagatttat cagcgtgcat ttggtggaca      660

gagcctcaag tttggaaagg gcgggcaggc ccatcggtgc tgctgtgtgg ctgatcggac      720

tggccactcg ctattgcaca ccttatatgg aaggtctctg cgatatgata ccagctattt      780

tgtggagtat tttgccttgg atctcctgat ggagaatggg gagtgccgtg gtgtcatcgc      840

actgtgcata gaggacgggt ccatccatcg cataagagca aagaacactg ttgttgccac      900

aggaggctac gggcgcacct acttcagctg cacgtctgcc cacaccagca ctggcgacgg      960

cacggccatg atcaccaggg caggccttcc ttgccaggac ctagagtttg ttcagttcca     1020

ccctacaggc atatatggtg ctggttgtct cattacggaa ggatgtcgtg gagagggagg     1080

cattctcatt aacagtcaag gcgaaaggtt tatggagcga tacgcccctg tcgcgaagga     1140

cctggcgtct agagatgtgg tgtctcggtc catgactctg gagatccgag aaggaagagg     1200

ctgtggccct gagaaagatc acgtctacct gcagctgcac cacctacctc cagagcagct     1260

ggccacgcgc ctgcctggca tttcagagac agccatgatc ttcgctggcg tggacgtcac     1320

gaaggagccg atccctgtcc tccccaccgt gcattataac atgggcggca ttcccaccaa     1380

ctacaagggg caggtcctga ggcacgtgaa tggccaggat cagattgtgc ccggcctgta     1440

cgcctgtggg gaggccgcct gtgcctcggt acatggtgcc aaccgcctcg gggcaaactc     1500

gctcttggac ctggttgtct ttggtcgggc atgtgccctg agcatcgaag agtcatgcag     1560

gcctggagat aaagtccctc caattaaacc aaacgctggg gaagaatctg tcatgaatct     1620

tgacaaattg agatttgctg atggaagcat aagaacatcg gaactgcgac tcagcatgca     1680

gaaggtgcgg attgatgagt acgattactc caagcccatc caggggcaac agaagaagcc     1740

ctttgaggag cactggagga agcacaccct gtcctatgtg gacgttggca ctgggaaggt     1800

cactctggaa tatagacccg tgatcgacaa aactttgaac gaggctgact gtgccaccgt     1860

cccgccagcc attcgctcct actgatgaga caagatgtgg tgatgacaga atcagctttt     1920

gtaattatgt ataatagctc atgcatgtgt ccatgtcata actgtcttca tacgcttctg     1980

cactctgggg aagaaggagt acattgaagg gagattggca cctagtggct gggagcttgc     2040

caggaaccca gtggccaggg agcgtggcac ttacctttgt cccttgcttc attcttgtga     2100

gatgataaaa ctgggcacag ctcttaaata aaatataaat gaacaaactt tcttttattt     2160

ccaaatccat ttgaaatatt ttactgttgt gactttagtc atatttgttg acctaaaaat     2220

caaatgtaat ctttgtattg tgttacatca aaatccagat attttgtata gtttcttttt     2280

tctttttctt ttcttttttt tttttgagac aggatcggtg cagtagtaca atcacagctc     2340

actgcagcct caaactcctg ggcagctcag gtgatcttcc tgactcagcc ttctgagtag     2400

ttggggctac aggtgtgcac caccatgccc agctcattta ttttgtaatt gtagggacag     2460

ggtctcactg tgttgcctag gctggtctca agtgatcctc cctccttggc ctcccaaggt     2520

gctggaatta taggtgtgaa caaacca                                         2547


<210>  90
<211>  664
<212>  PRT
<213>  Homo sapiens

<400>  90

Met Ser Gly Val Arg Gly Leu Ser Arg Leu Leu Ser Ala Arg Arg Leu 
1               5                   10                  15      


Ala Leu Ala Lys Ala Trp Pro Thr Val Leu Gln Thr Gly Thr Arg Gly 
            20                  25                  30          


Phe His Phe Thr Val Asp Gly Asn Lys Arg Ala Ser Ala Lys Val Ser 
        35                  40                  45              


Asp Ser Ile Ser Ala Gln Tyr Pro Val Val Asp His Glu Phe Asp Ala 
    50                  55                  60                  


Val Val Val Gly Ala Gly Gly Ala Gly Leu Arg Ala Ala Phe Gly Leu 
65                  70                  75                  80  


Ser Glu Ala Gly Phe Asn Thr Ala Cys Val Thr Lys Leu Phe Pro Thr 
                85                  90                  95      


Arg Ser His Thr Val Ala Ala Gln Gly Gly Ile Asn Ala Ala Leu Gly 
            100                 105                 110         


Asn Met Glu Glu Asp Asn Trp Arg Trp His Phe Tyr Asp Thr Val Lys 
        115                 120                 125             


Gly Ser Asp Trp Leu Gly Asp Gln Asp Ala Ile His Tyr Met Thr Glu 
    130                 135                 140                 


Gln Ala Pro Ala Ala Val Val Glu Leu Glu Asn Tyr Gly Met Pro Phe 
145                 150                 155                 160 


Ser Arg Thr Glu Asp Gly Lys Ile Tyr Gln Arg Ala Phe Gly Gly Gln 
                165                 170                 175     


Ser Leu Lys Phe Gly Lys Gly Gly Gln Ala His Arg Cys Cys Cys Val 
            180                 185                 190         


Ala Asp Arg Thr Gly His Ser Leu Leu His Thr Leu Tyr Gly Arg Ser 
        195                 200                 205             


Leu Arg Tyr Asp Thr Ser Tyr Phe Val Glu Tyr Phe Ala Leu Asp Leu 
    210                 215                 220                 


Leu Met Glu Asn Gly Glu Cys Arg Gly Val Ile Ala Leu Cys Ile Glu 
225                 230                 235                 240 


Asp Gly Ser Ile His Arg Ile Arg Ala Lys Asn Thr Val Val Ala Thr 
                245                 250                 255     


Gly Gly Tyr Gly Arg Thr Tyr Phe Ser Cys Thr Ser Ala His Thr Ser 
            260                 265                 270         


Thr Gly Asp Gly Thr Ala Met Ile Thr Arg Ala Gly Leu Pro Cys Gln 
        275                 280                 285             


Asp Leu Glu Phe Val Gln Phe His Pro Thr Gly Ile Tyr Gly Ala Gly 
    290                 295                 300                 


Cys Leu Ile Thr Glu Gly Cys Arg Gly Glu Gly Gly Ile Leu Ile Asn 
305                 310                 315                 320 


Ser Gln Gly Glu Arg Phe Met Glu Arg Tyr Ala Pro Val Ala Lys Asp 
                325                 330                 335     


Leu Ala Ser Arg Asp Val Val Ser Arg Ser Met Thr Leu Glu Ile Arg 
            340                 345                 350         


Glu Gly Arg Gly Cys Gly Pro Glu Lys Asp His Val Tyr Leu Gln Leu 
        355                 360                 365             


His His Leu Pro Pro Glu Gln Leu Ala Thr Arg Leu Pro Gly Ile Ser 
    370                 375                 380                 


Glu Thr Ala Met Ile Phe Ala Gly Val Asp Val Thr Lys Glu Pro Ile 
385                 390                 395                 400 


Pro Val Leu Pro Thr Val His Tyr Asn Met Gly Gly Ile Pro Thr Asn 
                405                 410                 415     


Tyr Lys Gly Gln Val Leu Arg His Val Asn Gly Gln Asp Gln Ile Val 
            420                 425                 430         


Pro Gly Leu Tyr Ala Cys Gly Glu Ala Ala Cys Ala Ser Val His Gly 
        435                 440                 445             


Ala Asn Arg Leu Gly Ala Asn Ser Leu Leu Asp Leu Val Val Phe Gly 
    450                 455                 460                 


Arg Ala Cys Ala Leu Ser Ile Glu Glu Ser Cys Arg Pro Gly Asp Lys 
465                 470                 475                 480 


Val Pro Pro Ile Lys Pro Asn Ala Gly Glu Glu Ser Val Met Asn Leu 
                485                 490                 495     


Asp Lys Leu Arg Phe Ala Asp Gly Ser Ile Arg Thr Ser Glu Leu Arg 
            500                 505                 510         


Leu Ser Met Gln Lys Ser Met Gln Asn His Ala Ala Val Phe Arg Val 
        515                 520                 525             


Gly Ser Val Leu Gln Glu Gly Cys Gly Lys Ile Ser Lys Leu Tyr Gly 
    530                 535                 540                 


Asp Leu Lys His Leu Lys Thr Phe Asp Arg Gly Met Val Trp Asn Thr 
545                 550                 555                 560 


Asp Leu Val Glu Thr Leu Glu Leu Gln Asn Leu Met Leu Cys Ala Leu 
                565                 570                 575     


Gln Thr Ile Tyr Gly Ala Glu Ala Arg Lys Glu Ser Arg Gly Ala His 
            580                 585                 590         


Ala Arg Glu Asp Tyr Lys Val Arg Ile Asp Glu Tyr Asp Tyr Ser Lys 
        595                 600                 605             


Pro Ile Gln Gly Gln Gln Lys Lys Pro Phe Glu Glu His Trp Arg Lys 
    610                 615                 620                 


His Thr Leu Ser Tyr Val Asp Val Gly Thr Gly Lys Val Thr Leu Glu 
625                 630                 635                 640 


Tyr Arg Pro Val Ile Asp Lys Thr Leu Asn Glu Ala Asp Cys Ala Thr 
                645                 650                 655     


Val Pro Pro Ala Ile Arg Ser Tyr 
            660                 


