                         SEQUENCE LISTING

<110>  Lead Discovery Center GmbH
 
<120>  4-Substituted pyrrolo[2,3-b]pyridine as ErbB modulators useful 
       for treating cancer

<130>  LDC-P03722WO

<160>  7     

<170>  PatentIn version 3.5

<210>  1
<211>  345
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  EGFR p.D770_N771insSVD mutation in BaF3

<400>  1
ttcaaaaaga tcaaagtgct gggctccggt gcgttcggca cggtgtataa gggactctgg       60

atcccagaag gtgagaaagt taaaattccc gtcgctatca aggaattaag agaagcaaca      120

tctccgaaag ccaacaagga aatcctcgat gaagcctacg tgatggccag cgtggactca      180

gtagacaacc cccacgtgtg ccgcctgctg ggcatctgcc tcacctccac cgtgcagctc      240

atcacgcagc tcatgccctt cggctgcctc ctggactatg tccgggaaca caaagacaat      300

attggctccc agtacctgct caactggtgt gtgcagatcg caaag                      345


<210>  2
<211>  345
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  EGFR p.H773_V774insNPH mutation in BaF3

<400>  2
ttcaaaaaga tcaaagtgct gggctccggt gcgttcggca cggtgtataa gggactctgg       60

atcccagaag gtgagaaagt taaaattccc gtcgctatca aggaattaag agaagcaaca      120

tctccgaaag ccaacaagga aatcctcgat gaagcctacg tgatggccag cgtggacaac      180

ccccacaatc cacatgtgtg ccgcctgctg ggcatctgcc tcacctccac cgtgcagctc      240

atcacgcagc tcatgccctt cggctgcctc ctggactatg tccgggaaca caaagacaat      300

attggctccc agtacctgct caactggtgt gtgcagatcg caaag                      345


<210>  3
<211>  345
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  EGFR p.V769_D770insASV mutation in BaF3

<400>  3
ttcaaaaaga tcaaagtgct gggctccggt gcgttcggca cggtgtataa gggactctgg       60

atcccagaag gtgagaaagt taaaattccc gtcgctatca aggaattaag agaagcaaca      120

tctccgaaag ccaacaagga aatcctcgat gaagcctacg tgatggccag cgtggcctca      180

gtcgacaacc cccacgtgtg ccgcctgctg ggcatctgcc tcacctccac cgtgcagctc      240

atcacgcagc tcatgccctt cggctgcctc ctggactatg tccgggaaca caaagacaat      300

attggctccc agtacctgct caactggtgt gtgcagatcg caaag                      345


<210>  4
<211>  342
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  EGFR p.P772_H773insPR mutation in BaF3

<400>  4
ttcaaaaaga tcaaagtgct gggctccggt gcgttcggca cggtgtataa gggactctgg       60

atcccagaag gtgagaaagt taaaattccc gtcgctatca aggaattaag agaagcaaca      120

tctccgaaag ccaacaagga aatcctcgat gaagcctacg tgatggccag cgtggacaac      180

cccccgcgtc acgtgtgccg cctgctgggc atctgcctca cctccaccgt gcagctcatc      240

acgcagctca tgcccttcgg ctgcctcctg gactatgtcc gggaacacaa agacaatatt      300

ggctcccagt acctgctcaa ctggtgtgtg cagatcgcaa ag                         342


<210>  5
<211>  501
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HER2 INS8 INS YVMA mutation BaF3

<400>  5
acacctagcg gagcgatgcc caaccaggcg cagatgcgga tcctgaaaga gacggagctg       60

aggaaggtga aggtgcttgg atctggcgct tttggcacag tctacaaggg catctggatc      120

cctgatgggg agaatgtgaa aattccagtg gccatcaaag tgttgaggga aaacacatcc      180

cccaaagcca acaaagaaat cttagacgaa gcatacgtga tggcttacgt gatggctggt      240

gtgggctccc catatgtctc ccgccttctg ggcatctgcc tgacatccac ggtgcagctg      300

gtgacacagc ttatgcccta tggctgcctc ttagaccatg tccgggaaaa ccgcggacgc      360

ctgggctccc aggacctgct gaactggtgt atgcagattg ccaaggggat gagctacctg      420

gaggatgtgc ggctcgtaca cagggacttg gccgctcgga acgtgctggt caagagtccc      480

aaccatgtca aaattacaga c                                                501


<210>  6
<211>  980
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  EGFR T790M mutation in BaF3

<400>  6
ggtgttccgg accccacaca gattcctaca ggccctcatg atattttaaa acacagcatc       60

ctcaaccttg aggcggaggt cttcataaca aagatactat cagttcccaa actcagagat      120

caggtgactc cgactcctcc tttatccaat gtgctcctca tggccactgt tgcctgggcc      180

tctctgtcat ggggaatccc cagatgcacc caggaggggc cctctcccac tgcatctgtc      240

acttcacagc cctgcgtaaa cgtccctgtg ctaggtcttt tgcaggcaca gcttttcctc      300

catgagtacg tattttgaaa ctcaagatcg cattcatgcg tcttcacctg gaaggggtcc      360

atgtgcccct ccttctggcc accatgcgaa gccacactga cgtgcctctc cctccctcca      420

ggaagcctac gtgatggcca gcgtggacaa cccccacgtg tgccgcctgc tgggcatctg      480

cctcacctcc accgtgcagc tcatcatgca gctcatgccc ttcggctgcc tcctggacta      540

tgtccgggaa cacaaagaca atattggctc ccagtacctg ctcaactggt gtgtgcagat      600

cgcaaaggta atcagggaag ggagatacgg ggaggggaga taaggagcca ggatcctcac      660

atgcggtctg cgctcctggg atagcaagag tttgccatgg ggatatgtgt gtgcgtgcat      720

gcagcacaca cacattcctt tattttggat tcaatcaagt tgatcttctt gtgcacaaat      780

cagtgcctgt cccatctgca tgtggaaact ctcatcaatc agctaccttt gaagaatttt      840

ctctttattg agtgctcagt gtggtctgat gtctctgttc ttatttctct ggaattcttt      900

gtgaatactg tggtgatttg tagtggagaa ggaatattgc ttcccccatt caggacttga      960

taacaaggta agcaagccag                                                  980


<210>  7
<211>  980
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  EGFR T790ML858R mutantion in BaF3

<400>  7
tccaaactgc acctacggat gcactgggcc aggtcttgaa ggctgtccaa cgaatgggcc       60

taagatcccg tccatcgcca ctgggatggt gggggccctc ctcttgctgc tggtggtggc      120

cctggggatc ggcctcttca tgcgaaggcg ccacatcgtt cggaagcgca cgctgcggag      180

gctgctgcag gagagggagc ttgtggagcc tcttacaccc agtggagaag ctcccaacca      240

agctctcttg aggatcttga aggaaactga attcaaaaag atcaaagtgc tgggctccgg      300

tgcgttcggc acggtgtata agggactctg gatcccagaa ggtgagaaag ttaaaattcc      360

cgtcgctatc aaggaattaa gagaagcaac atctccgaaa gccaacaagg aaatcctcga      420

tgaagcctac gtgatggcca gcgtggacaa cccccacgtg tgccgcctgc tgggcatctg      480

cctcacctcc accgtgcagc tcatcatgca gctcatgccc ttcggctgcc tcctggacta      540

tgtccgggaa cacaaagaca atattggctc ccagtacctg ctcaactggt gtgtgcagat      600

cgcaaagggc atgaactact tggaggaccg tcgcttggtg caccgcgacc tggcagccag      660

gaacgtactg gtgaaaacac cgcagcatgt caagatcaca gattttgggc gggccaaact      720

gctgggtgcg gaagagaaag aataccatgc agaaggaggc aaagtgccta tcaagtggat      780

ggcattggaa tcaattttac acagaatcta tacccaccag agtgatgtct ggagctacgg      840

ggtgaccgtt tgggagttga tgacctttgg atccaagcca tatgacggaa tccctgccag      900

cgagatctcc tccatcctgg agaaaggaga acgcctccct cagccaccca tatgtaccat      960

cgatgtctac atgatcatgg                                                  980


