                         SEQUENCE LISTING

<110>  SymThera Canada Ltd.
       EZERZER, Chai
 
<120>  Ca2+ REGULATED BINDING AGENTS

<130>  035159-0506567

<140>  PCT/IB2019/057162
<141>  2019-08-26

<150>  62/722,521
<151>  2018-08-24

<160>  96    

<170>  PatentIn version 3.5

<210>  1
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  1

Glu Ala Leu Asp Lys Tyr Ala Cys Asn Cys 
1               5                   10  


<210>  2
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  2

Asp Gly Tyr Cys Leu His Asp Gly Val Cys 
1               5                   10  


<210>  3
<211>  11
<212>  PRT
<213>  Homo sapiens

<400>  3

Met Tyr Ile Glu Leu Ala Leu Asp Lys Tyr Ala 
1               5                   10      


<210>  4
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  4

Cys Asn Cys Val Val Gly Tyr Ile Gly Glu 
1               5                   10  


<210>  5
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  5

Arg Cys Gln Tyr Arg Asp Leu Lys Trp Trp 
1               5                   10  


<210>  6
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  6

Tyr Arg Asp Leu Lys Trp Trp Glu Leu Arg 
1               5                   10  


<210>  7
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  7

Val Val Gly Tyr Ile Gly Glu Arg Cys Gln 
1               5                   10  


<210>  8
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  8

Cys Leu His Asp Gly Val Cys Met Tyr Ile 
1               5                   10  


<210>  9
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  9

Ser Glu Cys Pro Leu Ser His Asp Gly Tyr 
1               5                   10  


<210>  10
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  10

Asn Ser Asp Ser Glu Cys Pro Leu Ser His 
1               5                   10  


<210>  11
<211>  12
<212>  PRT
<213>  Homo sapiens

<400>  11

Asp Lys Asp Gly Asp Gly Thr Ile Thr Thr Lys Glu 
1               5                   10          


<210>  12
<211>  12
<212>  PRT
<213>  Homo sapiens

<400>  12

Asp Lys Asp Gly Asp Gly Cys Ile Thr Thr Arg Glu 
1               5                   10          


<210>  13
<211>  12
<212>  PRT
<213>  Homo sapiens

<400>  13

Asp Ala Asp Gly Gly Gly Asp Ile Ser Val Lys Glu 
1               5                   10          


<210>  14
<211>  12
<212>  PRT
<213>  Homo sapiens

<400>  14

Val Leu Gly Ala Glu Asp Gly Cys Ile Ser Thr Lys 
1               5                   10          


<210>  15
<211>  12
<212>  PRT
<213>  Homo sapiens

<400>  15

Asp Lys Gln Gln Arg Gly Lys Ile Lys Ala Thr Asp 
1               5                   10          


<210>  16
<211>  12
<212>  PRT
<213>  Homo sapiens

<400>  16

Asp Glu Glu Gly Asn Gly Glu Val Lys Thr Gly Glu 
1               5                   10          


<210>  17
<211>  12
<212>  PRT
<213>  Homo sapiens

<400>  17

Asp Lys Asp Gly Asn Gly Tyr Ile Ser Ala Ala Glu 
1               5                   10          


<210>  18
<211>  12
<212>  PRT
<213>  Homo sapiens

<400>  18

Asp Lys Asp Gly Asn Gly Phe Val Ser Ala Ala Glu 
1               5                   10          


<210>  19
<211>  12
<212>  PRT
<213>  Homo sapiens

<400>  19

Asp Lys Glu Lys Lys Gly Tyr Val Met Ala Ser Asp 
1               5                   10          


<210>  20
<211>  12
<212>  PRT
<213>  Homo sapiens

<400>  20

Asp Arg Asn Ala Asp Gly Tyr Ile Asp Pro Glu Glu 
1               5                   10          


<210>  21
<211>  12
<212>  PRT
<213>  Homo sapiens

<400>  21

Asp Lys Asn Ala Asp Gly Tyr Ile Asp Leu Asp Glu 
1               5                   10          


<210>  22
<211>  12
<212>  PRT
<213>  Homo sapiens

<400>  22

Asp Lys Glu Gly Lys Gly Tyr Ile Asp Trp Asn Thr 
1               5                   10          


<210>  23
<211>  12
<212>  PRT
<213>  Homo sapiens

<400>  23

Asp Gln Asp Gly Asp Gly His Ile Thr Val Asp Glu 
1               5                   10          


<210>  24
<211>  12
<212>  PRT
<213>  Homo sapiens

<400>  24

Asp Thr Asp Gly Asn Gly Thr Ile Asn Ala Gln Glu 
1               5                   10          


<210>  25
<211>  12
<212>  PRT
<213>  Homo sapiens

<400>  25

Asp Ser Asp Gly Asp Gly Glu Ile Ser Phe Gln Glu 
1               5                   10          


<210>  26
<211>  12
<212>  PRT
<213>  Homo sapiens

<400>  26

Asp Ala Asp Gly Asn Gly Thr Ile Asp Phe Pro Glu 
1               5                   10          


<210>  27
<211>  12
<212>  PRT
<213>  Homo sapiens

<400>  27

Asp Arg Asp Gly Asn Gly Thr Val Asp Phe Pro Glu 
1               5                   10          


<210>  28
<211>  12
<212>  PRT
<213>  Homo sapiens

<400>  28

Asp Glu Asp Gly Ser Gly Thr Ile Asp Phe Glu Glu 
1               5                   10          


<210>  29
<211>  12
<212>  PRT
<213>  Homo sapiens

<400>  29

Asp Glu Asp Gly Ser Gly Thr Val Asp Phe Asp Glu 
1               5                   10          


<210>  30
<211>  12
<212>  PRT
<213>  Homo sapiens

<400>  30

Gly Ile Asp Gly Asn Gly Glu Leu Asp Phe Ser Thr 
1               5                   10          


<210>  31
<211>  12
<212>  PRT
<213>  Homo sapiens

<400>  31

Asp Lys Asn Asn Asp Gly Arg Ile Asp Phe Asp Glu 
1               5                   10          


<210>  32
<211>  12
<212>  PRT
<213>  Homo sapiens

<400>  32

Asp Lys Asn Asn Asp Gly Arg Ile Asp Tyr Asp Glu 
1               5                   10          


<210>  33
<211>  12
<212>  PRT
<213>  Homo sapiens

<400>  33

Asp Arg Asp Asn Lys Gly Phe Phe Asn Cys Asp Gly 
1               5                   10          


<210>  34
<211>  12
<212>  PRT
<213>  Homo sapiens

<400>  34

Asp Ile Asp Gly Asp Gly Gln Val Asn Tyr Glu Glu 
1               5                   10          


<210>  35
<211>  12
<212>  PRT
<213>  Homo sapiens

<400>  35

Asp Thr Asp Gly Asp Gly Gln Val Asn Tyr Glu Glu 
1               5                   10          


<210>  36
<211>  12
<212>  PRT
<213>  Homo sapiens

<400>  36

Asp Val Asp Gln Asp Gly Arg Val Asn Tyr Glu Glu 
1               5                   10          


<210>  37
<211>  12
<212>  PRT
<213>  Homo sapiens

<400>  37

Asp Lys Asp Gly Asp Arg Thr Ile Asp Tyr Glu Glu 
1               5                   10          


<210>  38
<211>  12
<212>  PRT
<213>  Homo sapiens

<400>  38

Asp Ile Glu Pro Asn Gly Lys Val Lys Tyr Asp Glu 
1               5                   10          


<210>  39
<211>  12
<212>  PRT
<213>  Homo sapiens

<400>  39

Asp Lys Asp Gly Asp Gly Lys Ile Gly Val Asp Glu 
1               5                   10          


<210>  40
<211>  11
<212>  PRT
<213>  Homo sapiens

<400>  40

Leu Gly Thr Val Met Arg Ser Leu Gly Gln Asn 
1               5                   10      


<210>  41
<211>  11
<212>  PRT
<213>  Homo sapiens

<400>  41

Leu Gly Thr Val Met Arg Met Leu Gly Gln Thr 
1               5                   10      


<210>  42
<211>  12
<212>  PRT
<213>  Homo sapiens

<400>  42

Glu Leu Gly Lys Val Met Arg Met Leu Gly Gln Asn 
1               5                   10          


<210>  43
<211>  11
<212>  PRT
<213>  Homo sapiens

<400>  43

Leu Met Val Ala Met Arg Cys Leu Gly Ala Ser 
1               5                   10      


<210>  44
<211>  11
<212>  PRT
<213>  Homo sapiens

<400>  44

Leu Glu Trp Leu Met Ser Leu Leu Gly Ile Asn 
1               5                   10      


<210>  45
<211>  11
<212>  PRT
<213>  Homo sapiens

<400>  45

Leu Arg His Val Met Thr Asn Leu Gly Glu Lys 
1               5                   10      


<210>  46
<211>  11
<212>  PRT
<213>  Homo sapiens

<400>  46

Leu Arg His Val Met Thr Arg Leu Gly Glu Lys 
1               5                   10      


<210>  47
<211>  11
<212>  PRT
<213>  Homo sapiens

<400>  47

Leu Arg Ser Lys Leu Thr Ser Leu Gly Glu Lys 
1               5                   10      


<210>  48
<211>  11
<212>  PRT
<213>  Homo sapiens

<400>  48

Leu Ala Glu Ile Phe Arg Ala Ser Gly Glu His 
1               5                   10      


<210>  49
<211>  11
<212>  PRT
<213>  Homo sapiens

<400>  49

Leu Lys Ile Met Leu Gln Ala Thr Gly Glu Thr 
1               5                   10      


<210>  50
<211>  11
<212>  PRT
<213>  Homo sapiens

<400>  50

Leu Lys Tyr Val Leu Met Asn Ala Gly Glu Pro 
1               5                   10      


<210>  51
<211>  11
<212>  PRT
<213>  Homo sapiens

<400>  51

Leu Arg Arg Ala Met Ala Gly Leu Gly Gln Pro 
1               5                   10      


<210>  52
<211>  11
<212>  PRT
<213>  Homo sapiens

<400>  52

Leu Gly Ala Ala Leu Lys Ala Thr Gly Lys Asn 
1               5                   10      


<210>  53
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  53

Phe Leu Thr Ala Ala Lys Lys Ala Arg 
1               5                   


<210>  54
<211>  11
<212>  PRT
<213>  Homo sapiens

<400>  54

Phe Leu Thr Met Met Ala Arg Lys Met Lys Asp 
1               5                   10      


<210>  55
<211>  11
<212>  PRT
<213>  Homo sapiens

<400>  55

Phe Leu Gly Met Met Ala Arg Lys Met Lys Asp 
1               5                   10      


<210>  56
<211>  11
<212>  PRT
<213>  Homo sapiens

<400>  56

Phe Leu Val Met Met Val Arg Gln Met Lys Glu 
1               5                   10      


<210>  57
<211>  11
<212>  PRT
<213>  Homo sapiens

<400>  57

Phe Leu Val Met Met Val Arg Cys Met Lys Asp 
1               5                   10      


<210>  58
<211>  11
<212>  PRT
<213>  Homo sapiens

<400>  58

Phe Leu Thr Ile Met His Met Gln Ile Lys Gln 
1               5                   10      


<210>  59
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  59

Phe Leu Lys Met Met Glu Gly Val Gln 
1               5                   


<210>  60
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  60

Phe Leu Glu Phe Met Lys Gly Val Glu 
1               5                   


<210>  61
<211>  11
<212>  PRT
<213>  Homo sapiens

<400>  61

Phe Leu Ala Leu Met Gly Val Tyr His Glu Lys 
1               5                   10      


<210>  62
<211>  8
<212>  PRT
<213>  Homo sapiens

<400>  62

Phe Val Gln Met Met Thr Ala Lys 
1               5               


<210>  63
<211>  7
<212>  PRT
<213>  Homo sapiens

<400>  63

Phe Val Arg Val Leu Ser Lys 
1               5           


<210>  64
<211>  8
<212>  PRT
<213>  Homo sapiens

<400>  64

Phe Ala Arg Met Leu Ala Gln Glu 
1               5               


<210>  65
<211>  11
<212>  PRT
<213>  Homo sapiens

<400>  65

Phe Val Ala Met Met Thr Gly Glu Ser Phe Lys 
1               5                   10      


<210>  66
<211>  11
<212>  PRT
<213>  Homo sapiens

<400>  66

Phe Ile His Lys Ile Thr Leu Pro Gly Arg Asp 
1               5                   10      


<210>  67
<211>  8
<212>  PRT
<213>  Homo sapiens

<400>  67

Phe Ser Thr Leu Val Ala Glu Ser 
1               5               


<210>  68
<211>  23
<212>  PRT
<213>  Homo sapiens

<400>  68

Asp Lys Asp Gly Asp Gly Thr Ile Thr Thr Lys Glu Leu Gly Thr Val 
1               5                   10                  15      


Met Arg Ser Leu Gly Gln Asn 
            20              


<210>  69
<211>  23
<212>  PRT
<213>  Homo sapiens

<400>  69

Asp Lys Asp Gly Asp Gly Cys Ile Thr Thr Arg Glu Leu Gly Thr Val 
1               5                   10                  15      


Met Arg Ser Leu Gly Gln Asn 
            20              


<210>  70
<211>  23
<212>  PRT
<213>  Homo sapiens

<400>  70

Asp Ala Asp Gly Gly Gly Asp Ile Ser Val Lys Glu Leu Gly Thr Val 
1               5                   10                  15      


Met Arg Met Leu Gly Gln Thr 
            20              


<210>  71
<211>  24
<212>  PRT
<213>  Homo sapiens

<400>  71

Val Leu Gly Ala Glu Asp Gly Cys Ile Ser Thr Lys Glu Leu Gly Lys 
1               5                   10                  15      


Val Met Arg Met Leu Gly Gln Asn 
            20                  


<210>  72
<211>  23
<212>  PRT
<213>  Homo sapiens

<400>  72

Asp Lys Gln Gln Arg Gly Lys Ile Lys Ala Thr Asp Leu Met Val Ala 
1               5                   10                  15      


Met Arg Cys Leu Gly Ala Ser 
            20              


<210>  73
<211>  23
<212>  PRT
<213>  Homo sapiens

<400>  73

Asp Glu Glu Gly Asn Gly Glu Val Lys Thr Gly Glu Leu Glu Trp Leu 
1               5                   10                  15      


Met Ser Leu Leu Gly Ile Asn 
            20              


<210>  74
<211>  23
<212>  PRT
<213>  Homo sapiens

<400>  74

Asp Lys Asp Gly Asn Gly Tyr Ile Ser Ala Ala Glu Leu Arg His Val 
1               5                   10                  15      


Met Thr Asn Leu Gly Glu Lys 
            20              


<210>  75
<211>  23
<212>  PRT
<213>  Homo sapiens

<400>  75

Asp Lys Asp Gly Asn Gly Phe Val Ser Ala Ala Glu Leu Arg His Val 
1               5                   10                  15      


Met Thr Arg Leu Gly Glu Lys 
            20              


<210>  76
<211>  23
<212>  PRT
<213>  Homo sapiens

<400>  76

Asp Lys Glu Lys Lys Gly Tyr Val Met Ala Ser Asp Leu Arg Ser Lys 
1               5                   10                  15      


Leu Thr Ser Leu Gly Glu Lys 
            20              


<210>  77
<211>  23
<212>  PRT
<213>  Homo sapiens

<400>  77

Asp Arg Asn Ala Asp Gly Tyr Ile Asp Pro Glu Glu Leu Ala Glu Ile 
1               5                   10                  15      


Phe Arg Ala Ser Gly Glu His 
            20              


<210>  78
<211>  23
<212>  PRT
<213>  Homo sapiens

<400>  78

Asp Lys Asn Ala Asp Gly Tyr Ile Asp Leu Asp Glu Leu Lys Ile Met 
1               5                   10                  15      


Leu Gln Ala Thr Gly Glu Thr 
            20              


<210>  79
<211>  23
<212>  PRT
<213>  Homo sapiens

<400>  79

Asp Lys Glu Gly Lys Gly Tyr Ile Asp Trp Asn Thr Leu Lys Tyr Val 
1               5                   10                  15      


Leu Met Asn Ala Gly Glu Pro 
            20              


<210>  80
<211>  23
<212>  PRT
<213>  Homo sapiens

<400>  80

Asp Gln Asp Gly Asp Gly His Ile Thr Val Asp Glu Leu Arg Arg Ala 
1               5                   10                  15      


Met Ala Gly Leu Gly Gln Pro 
            20              


<210>  81
<211>  23
<212>  PRT
<213>  Homo sapiens

<400>  81

Asp Thr Asp Gly Asn Gly Thr Ile Asn Ala Gln Glu Leu Gly Ala Ala 
1               5                   10                  15      


Leu Lys Ala Thr Gly Lys Asn 
            20              


<210>  82
<211>  21
<212>  PRT
<213>  Homo sapiens

<400>  82

Asp Ser Asp Gly Asp Gly Glu Ile Ser Phe Gln Glu Phe Leu Thr Ala 
1               5                   10                  15      


Ala Lys Lys Ala Arg 
            20      


<210>  83
<211>  23
<212>  PRT
<213>  Homo sapiens

<400>  83

Asp Ala Asp Gly Asn Gly Thr Ile Asp Phe Pro Glu Phe Leu Thr Met 
1               5                   10                  15      


Met Ala Arg Lys Met Lys Asp 
            20              


<210>  84
<211>  23
<212>  PRT
<213>  Homo sapiens

<400>  84

Asp Arg Asp Gly Asn Gly Thr Val Asp Phe Pro Glu Phe Leu Gly Met 
1               5                   10                  15      


Met Ala Arg Lys Met Lys Asp 
            20              


<210>  85
<211>  23
<212>  PRT
<213>  Homo sapiens

<400>  85

Asp Glu Asp Gly Ser Gly Thr Ile Asp Phe Glu Glu Phe Leu Val Met 
1               5                   10                  15      


Met Val Arg Gln Met Lys Glu 
            20              


<210>  86
<211>  23
<212>  PRT
<213>  Homo sapiens

<400>  86

Asp Glu Asp Gly Ser Gly Thr Val Asp Phe Asp Glu Phe Leu Val Met 
1               5                   10                  15      


Met Val Arg Cys Met Lys Asp 
            20              


<210>  87
<211>  23
<212>  PRT
<213>  Homo sapiens

<400>  87

Gly Ile Asp Gly Asn Gly Glu Leu Asp Phe Ser Thr Phe Leu Thr Ile 
1               5                   10                  15      


Met His Met Gln Ile Lys Gln 
            20              


<210>  88
<211>  21
<212>  PRT
<213>  Homo sapiens

<400>  88

Asp Lys Asn Asn Asp Gly Arg Ile Asp Phe Asp Glu Phe Leu Lys Met 
1               5                   10                  15      


Met Glu Gly Val Gln 
            20      


<210>  89
<211>  21
<212>  PRT
<213>  Homo sapiens

<400>  89

Asp Lys Asn Asn Asp Gly Arg Ile Asp Tyr Asp Glu Phe Leu Glu Phe 
1               5                   10                  15      


Met Lys Gly Val Glu 
            20      


<210>  90
<211>  23
<212>  PRT
<213>  Homo sapiens

<400>  90

Asp Arg Asp Asn Lys Gly Phe Phe Asn Cys Asp Gly Phe Leu Ala Leu 
1               5                   10                  15      


Met Gly Val Tyr His Glu Lys 
            20              


<210>  91
<211>  20
<212>  PRT
<213>  Homo sapiens

<400>  91

Asp Ile Asp Gly Asp Gly Gln Val Asn Tyr Glu Glu Phe Val Gln Met 
1               5                   10                  15      


Met Thr Ala Lys 
            20  


<210>  92
<211>  19
<212>  PRT
<213>  Homo sapiens

<400>  92

Asp Thr Asp Gly Asp Gly Gln Val Asn Tyr Glu Glu Phe Val Arg Val 
1               5                   10                  15      


Leu Ser Lys 
            


<210>  93
<211>  20
<212>  PRT
<213>  Homo sapiens

<400>  93

Asp Val Asp Gln Asp Gly Arg Val Asn Tyr Glu Glu Phe Ala Arg Met 
1               5                   10                  15      


Leu Ala Gln Glu 
            20  


<210>  94
<211>  23
<212>  PRT
<213>  Homo sapiens

<400>  94

Asp Lys Asp Gly Asp Arg Thr Ile Asp Tyr Glu Glu Phe Val Ala Met 
1               5                   10                  15      


Met Thr Gly Glu Ser Phe Lys 
            20              


<210>  95
<211>  23
<212>  PRT
<213>  Homo sapiens

<400>  95

Asp Ile Glu Pro Asn Gly Lys Val Lys Tyr Asp Glu Phe Ile His Lys 
1               5                   10                  15      


Ile Thr Leu Pro Gly Arg Asp 
            20              


<210>  96
<211>  20
<212>  PRT
<213>  Homo sapiens

<400>  96

Asp Lys Asp Gly Asp Gly Lys Ile Gly Val Asp Glu Phe Ser Thr Leu 
1               5                   10                  15      


Val Ala Glu Ser 
            20  


