                         SEQUENCE LISTING

<110>  The Jackson Laboratory
 
<120>  METHODS AND COMPOSITIONS FOR RECRUITING DNA REPAIR PROTEINS

<130>  J0227.70061WO00

<140>  Not Yet Assigned
<141>  2019-08-19

<150>  US 62/720,847
<151>  2018-08-21

<160>  91    

<170>  PatentIn version 3.5

<210>  1
<211>  1863
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  1

Met Asp Leu Ser Ala Leu Arg Val Glu Glu Val Gln Asn Val Ile Asn 
1               5                   10                  15      


Ala Met Gln Lys Ile Leu Glu Cys Pro Ile Cys Leu Glu Leu Ile Lys 
            20                  25                  30          


Glu Pro Val Ser Thr Lys Cys Asp His Ile Phe Cys Lys Phe Cys Met 
        35                  40                  45              


Leu Lys Leu Leu Asn Gln Lys Lys Gly Pro Ser Gln Cys Pro Leu Cys 
    50                  55                  60                  


Lys Asn Asp Ile Thr Lys Arg Ser Leu Gln Glu Ser Thr Arg Phe Ser 
65                  70                  75                  80  


Gln Leu Val Glu Glu Leu Leu Lys Ile Ile Cys Ala Phe Gln Leu Asp 
                85                  90                  95      


Thr Gly Leu Glu Tyr Ala Asn Ser Tyr Asn Phe Ala Lys Lys Glu Asn 
            100                 105                 110         


Asn Ser Pro Glu His Leu Lys Asp Glu Val Ser Ile Ile Gln Ser Met 
        115                 120                 125             


Gly Tyr Arg Asn Arg Ala Lys Arg Leu Leu Gln Ser Glu Pro Glu Asn 
    130                 135                 140                 


Pro Ser Leu Gln Glu Thr Ser Leu Ser Val Gln Leu Ser Asn Leu Gly 
145                 150                 155                 160 


Thr Val Arg Thr Leu Arg Thr Lys Gln Arg Ile Gln Pro Gln Lys Thr 
                165                 170                 175     


Ser Val Tyr Ile Glu Leu Gly Ser Asp Ser Ser Glu Asp Thr Val Asn 
            180                 185                 190         


Lys Ala Thr Tyr Cys Ser Val Gly Asp Gln Glu Leu Leu Gln Ile Thr 
        195                 200                 205             


Pro Gln Gly Thr Arg Asp Glu Ile Ser Leu Asp Ser Ala Lys Lys Ala 
    210                 215                 220                 


Ala Cys Glu Phe Ser Glu Thr Asp Val Thr Asn Thr Glu His His Gln 
225                 230                 235                 240 


Pro Ser Asn Asn Asp Leu Asn Thr Thr Glu Lys Arg Ala Ala Glu Arg 
                245                 250                 255     


His Pro Glu Lys Tyr Gln Gly Ser Ser Val Ser Asn Leu His Val Glu 
            260                 265                 270         


Pro Cys Gly Thr Asn Thr His Ala Ser Ser Leu Gln His Glu Asn Ser 
        275                 280                 285             


Ser Leu Leu Leu Thr Lys Asp Arg Met Asn Val Glu Lys Ala Glu Phe 
    290                 295                 300                 


Cys Asn Lys Ser Lys Gln Pro Gly Leu Ala Arg Ser Gln His Asn Arg 
305                 310                 315                 320 


Trp Ala Gly Ser Lys Glu Thr Cys Asn Asp Arg Arg Thr Pro Ser Thr 
                325                 330                 335     


Glu Lys Lys Val Asp Leu Asn Ala Asp Pro Leu Cys Glu Arg Lys Glu 
            340                 345                 350         


Trp Asn Lys Gln Lys Leu Pro Cys Ser Glu Asn Pro Arg Asp Thr Glu 
        355                 360                 365             


Asp Val Pro Trp Ile Thr Leu Asn Ser Ser Ile Gln Lys Val Asn Glu 
    370                 375                 380                 


Trp Phe Ser Arg Ser Asp Glu Leu Leu Gly Ser Asp Asp Ser His Asp 
385                 390                 395                 400 


Gly Glu Ser Glu Ser Asn Ala Lys Val Ala Asp Val Leu Asp Val Leu 
                405                 410                 415     


Asn Glu Val Asp Glu Tyr Ser Gly Ser Ser Glu Lys Ile Asp Leu Leu 
            420                 425                 430         


Ala Ser Asp Pro His Glu Ala Leu Ile Cys Lys Ser Glu Arg Val His 
        435                 440                 445             


Ser Lys Ser Val Glu Ser Asn Ile Glu Asp Lys Ile Phe Gly Lys Thr 
    450                 455                 460                 


Tyr Arg Lys Lys Ala Ser Leu Pro Asn Leu Ser His Val Thr Glu Asn 
465                 470                 475                 480 


Leu Ile Ile Gly Ala Phe Val Thr Glu Pro Gln Ile Ile Gln Glu Arg 
                485                 490                 495     


Pro Leu Thr Asn Lys Leu Lys Arg Lys Arg Arg Pro Thr Ser Gly Leu 
            500                 505                 510         


His Pro Glu Asp Phe Ile Lys Lys Ala Asp Leu Ala Val Gln Lys Thr 
        515                 520                 525             


Pro Glu Met Ile Asn Gln Gly Thr Asn Gln Thr Glu Gln Asn Gly Gln 
    530                 535                 540                 


Val Met Asn Ile Thr Asn Ser Gly His Glu Asn Lys Thr Lys Gly Asp 
545                 550                 555                 560 


Ser Ile Gln Asn Glu Lys Asn Pro Asn Pro Ile Glu Ser Leu Glu Lys 
                565                 570                 575     


Glu Ser Ala Phe Lys Thr Lys Ala Glu Pro Ile Ser Ser Ser Ile Ser 
            580                 585                 590         


Asn Met Glu Leu Glu Leu Asn Ile His Asn Ser Lys Ala Pro Lys Lys 
        595                 600                 605             


Asn Arg Leu Arg Arg Lys Ser Ser Thr Arg His Ile His Ala Leu Glu 
    610                 615                 620                 


Leu Val Val Ser Arg Asn Leu Ser Pro Pro Asn Cys Thr Glu Leu Gln 
625                 630                 635                 640 


Ile Asp Ser Cys Ser Ser Ser Glu Glu Ile Lys Lys Lys Lys Tyr Asn 
                645                 650                 655     


Gln Met Pro Val Arg His Ser Arg Asn Leu Gln Leu Met Glu Gly Lys 
            660                 665                 670         


Glu Pro Ala Thr Gly Ala Lys Lys Ser Asn Lys Pro Asn Glu Gln Thr 
        675                 680                 685             


Ser Lys Arg His Asp Ser Asp Thr Phe Pro Glu Leu Lys Leu Thr Asn 
    690                 695                 700                 


Ala Pro Gly Ser Phe Thr Lys Cys Ser Asn Thr Ser Glu Leu Lys Glu 
705                 710                 715                 720 


Phe Val Asn Pro Ser Leu Pro Arg Glu Glu Lys Glu Glu Lys Leu Glu 
                725                 730                 735     


Thr Val Lys Val Ser Asn Asn Ala Glu Asp Pro Lys Asp Leu Met Leu 
            740                 745                 750         


Ser Gly Glu Arg Val Leu Gln Thr Glu Arg Ser Val Glu Ser Ser Ser 
        755                 760                 765             


Ile Ser Leu Val Pro Gly Thr Asp Tyr Gly Thr Gln Glu Ser Ile Ser 
    770                 775                 780                 


Leu Leu Glu Val Ser Thr Leu Gly Lys Ala Lys Thr Glu Pro Asn Lys 
785                 790                 795                 800 


Cys Val Ser Gln Cys Ala Ala Phe Glu Asn Pro Lys Gly Leu Ile His 
                805                 810                 815     


Gly Cys Ser Lys Asp Asn Arg Asn Asp Thr Glu Gly Phe Lys Tyr Pro 
            820                 825                 830         


Leu Gly His Glu Val Asn His Ser Arg Glu Thr Ser Ile Glu Met Glu 
        835                 840                 845             


Glu Ser Glu Leu Asp Ala Gln Tyr Leu Gln Asn Thr Phe Lys Val Ser 
    850                 855                 860                 


Lys Arg Gln Ser Phe Ala Leu Phe Ser Asn Pro Gly Asn Ala Glu Glu 
865                 870                 875                 880 


Glu Cys Ala Thr Phe Ser Ala His Ser Gly Ser Leu Lys Lys Gln Ser 
                885                 890                 895     


Pro Lys Val Thr Phe Glu Cys Glu Gln Lys Glu Glu Asn Gln Gly Lys 
            900                 905                 910         


Asn Glu Ser Asn Ile Lys Pro Val Gln Thr Val Asn Ile Thr Ala Gly 
        915                 920                 925             


Phe Pro Val Val Gly Gln Lys Asp Lys Pro Val Asp Asn Ala Lys Cys 
    930                 935                 940                 


Ser Ile Lys Gly Gly Ser Arg Phe Cys Leu Ser Ser Gln Phe Arg Gly 
945                 950                 955                 960 


Asn Glu Thr Gly Leu Ile Thr Pro Asn Lys His Gly Leu Leu Gln Asn 
                965                 970                 975     


Pro Tyr Arg Ile Pro Pro Leu Phe Pro Ile Lys Ser Phe Val Lys Thr 
            980                 985                 990         


Lys Cys Lys Lys Asn Leu Leu Glu  Glu Asn Phe Glu Glu  His Ser Met 
        995                 1000                 1005             


Ser Pro  Glu Arg Glu Met Gly  Asn Glu Asn Ile Pro  Ser Thr Val 
    1010                 1015                 1020             


Ser Thr  Ile Ser Arg Asn Asn  Ile Arg Glu Asn Val  Phe Lys Gly 
    1025                 1030                 1035             


Ala Ser  Ser Ser Asn Ile Asn  Glu Val Gly Ser Ser  Thr Asn Glu 
    1040                 1045                 1050             


Val Gly  Ser Ser Ile Asn Glu  Ile Gly Ser Ser Asp  Glu Asn Ile 
    1055                 1060                 1065             


Gln Ala  Glu Leu Gly Arg Asn  Arg Gly Pro Lys Leu  Asn Ala Met 
    1070                 1075                 1080             


Leu Arg  Leu Gly Val Leu Gln  Pro Glu Val Tyr Lys  Gln Ser Leu 
    1085                 1090                 1095             


Pro Gly  Ser Asn Cys Lys His  Pro Glu Ile Lys Lys  Gln Glu Tyr 
    1100                 1105                 1110             


Glu Glu  Val Val Gln Thr Val  Asn Thr Asp Phe Ser  Pro Tyr Leu 
    1115                 1120                 1125             


Ile Ser  Asp Asn Leu Glu Gln  Pro Met Gly Ser Ser  His Thr Ser 
    1130                 1135                 1140             


Gln Val  Cys Ser Glu Thr Pro  Asp Asp Leu Leu Asp  Asp Gly Glu 
    1145                 1150                 1155             


Ile Lys  Glu Asp Thr Ser Phe  Ala Glu Asn Asp Ile  Lys Glu Ser 
    1160                 1165                 1170             


Ser Ala  Val Phe Ser Lys Ser  Val Gln Arg Gly Glu  Leu Ser Arg 
    1175                 1180                 1185             


Ser Pro  Ser Pro Phe Thr His  Thr His Leu Ala Gln  Gly Tyr Arg 
    1190                 1195                 1200             


Arg Gly  Ala Lys Lys Leu Glu  Ser Ser Glu Glu Asn  Leu Ser Ser 
    1205                 1210                 1215             


Glu Asp  Glu Glu Leu Pro Cys  Phe Gln His Leu Leu  Phe Gly Lys 
    1220                 1225                 1230             


Val Asn  Asn Ile Pro Ser Gln  Ser Thr Arg His Ser  Thr Val Ala 
    1235                 1240                 1245             


Thr Glu  Cys Leu Ser Lys Asn  Thr Glu Glu Asn Leu  Leu Ser Leu 
    1250                 1255                 1260             


Lys Asn  Ser Leu Asn Asp Cys  Ser Asn Gln Val Ile  Leu Ala Lys 
    1265                 1270                 1275             


Ala Ser  Gln Glu His His Leu  Ser Glu Glu Thr Lys  Cys Ser Ala 
    1280                 1285                 1290             


Ser Leu  Phe Ser Ser Gln Cys  Ser Glu Leu Glu Asp  Leu Thr Ala 
    1295                 1300                 1305             


Asn Thr  Asn Thr Gln Asp Pro  Phe Leu Ile Gly Ser  Ser Lys Gln 
    1310                 1315                 1320             


Met Arg  His Gln Ser Glu Ser  Gln Gly Val Gly Leu  Ser Asp Lys 
    1325                 1330                 1335             


Glu Leu  Val Ser Asp Asp Glu  Glu Arg Gly Thr Gly  Leu Glu Glu 
    1340                 1345                 1350             


Asn Asn  Gln Glu Glu Gln Ser  Met Asp Ser Asn Leu  Gly Glu Ala 
    1355                 1360                 1365             


Ala Ser  Gly Cys Glu Ser Glu  Thr Ser Val Ser Glu  Asp Cys Ser 
    1370                 1375                 1380             


Gly Leu  Ser Ser Gln Ser Asp  Ile Leu Thr Thr Gln  Gln Arg Asp 
    1385                 1390                 1395             


Thr Met  Gln His Asn Leu Ile  Lys Leu Gln Gln Glu  Met Ala Glu 
    1400                 1405                 1410             


Leu Glu  Ala Val Leu Glu Gln  His Gly Ser Gln Pro  Ser Asn Ser 
    1415                 1420                 1425             


Tyr Pro  Ser Ile Ile Ser Asp  Ser Ser Ala Leu Glu  Asp Leu Arg 
    1430                 1435                 1440             


Asn Pro  Glu Gln Ser Thr Ser  Glu Lys Ala Val Leu  Thr Ser Gln 
    1445                 1450                 1455             


Lys Ser  Ser Glu Tyr Pro Ile  Ser Gln Asn Pro Glu  Gly Leu Ser 
    1460                 1465                 1470             


Ala Asp  Lys Phe Glu Val Ser  Ala Asp Ser Ser Thr  Ser Lys Asn 
    1475                 1480                 1485             


Lys Glu  Pro Gly Val Glu Arg  Ser Ser Pro Ser Lys  Cys Pro Ser 
    1490                 1495                 1500             


Leu Asp  Asp Arg Trp Tyr Met  His Ser Cys Ser Gly  Ser Leu Gln 
    1505                 1510                 1515             


Asn Arg  Asn Tyr Pro Ser Gln  Glu Glu Leu Ile Lys  Val Val Asp 
    1520                 1525                 1530             


Val Glu  Glu Gln Gln Leu Glu  Glu Ser Gly Pro His  Asp Leu Thr 
    1535                 1540                 1545             


Glu Thr  Ser Tyr Leu Pro Arg  Gln Asp Leu Glu Gly  Thr Pro Tyr 
    1550                 1555                 1560             


Leu Glu  Ser Gly Ile Ser Leu  Phe Ser Asp Asp Pro  Glu Ser Asp 
    1565                 1570                 1575             


Pro Ser  Glu Asp Arg Ala Pro  Glu Ser Ala Arg Val  Gly Asn Ile 
    1580                 1585                 1590             


Pro Ser  Ser Thr Ser Ala Leu  Lys Val Pro Gln Leu  Lys Val Ala 
    1595                 1600                 1605             


Glu Ser  Ala Gln Gly Pro Ala  Ala Ala His Thr Thr  Asp Thr Ala 
    1610                 1615                 1620             


Gly Tyr  Asn Ala Met Glu Glu  Ser Val Ser Arg Glu  Lys Pro Glu 
    1625                 1630                 1635             


Leu Thr  Ala Ser Thr Glu Arg  Val Asn Lys Arg Met  Ser Met Val 
    1640                 1645                 1650             


Val Ser  Gly Leu Thr Pro Glu  Glu Phe Met Leu Val  Tyr Lys Phe 
    1655                 1660                 1665             


Ala Arg  Lys His His Ile Thr  Leu Thr Asn Leu Ile  Thr Glu Glu 
    1670                 1675                 1680             


Thr Thr  His Val Val Met Lys  Thr Asp Ala Glu Phe  Val Cys Glu 
    1685                 1690                 1695             


Arg Thr  Leu Lys Tyr Phe Leu  Gly Ile Ala Gly Gly  Lys Trp Val 
    1700                 1705                 1710             


Val Ser  Tyr Phe Trp Val Thr  Gln Ser Ile Lys Glu  Arg Lys Met 
    1715                 1720                 1725             


Leu Asn  Glu His Asp Phe Glu  Val Arg Gly Asp Val  Val Asn Gly 
    1730                 1735                 1740             


Arg Asn  His Gln Gly Pro Lys  Arg Ala Arg Glu Ser  Gln Asp Arg 
    1745                 1750                 1755             


Lys Ile  Phe Arg Gly Leu Glu  Ile Cys Cys Tyr Gly  Pro Phe Thr 
    1760                 1765                 1770             


Asn Met  Pro Thr Asp Gln Leu  Glu Trp Met Val Gln  Leu Cys Gly 
    1775                 1780                 1785             


Ala Ser  Val Val Lys Glu Leu  Ser Ser Phe Thr Leu  Gly Thr Gly 
    1790                 1795                 1800             


Val His  Pro Ile Val Val Val  Gln Pro Asp Ala Trp  Thr Glu Asp 
    1805                 1810                 1815             


Asn Gly  Phe His Ala Ile Gly  Gln Met Cys Glu Ala  Pro Val Val 
    1820                 1825                 1830             


Thr Arg  Glu Trp Val Leu Asp  Ser Val Ala Leu Tyr  Gln Cys Gln 
    1835                 1840                 1845             


Glu Leu  Asp Thr Tyr Leu Ile  Pro Gln Ile Pro His  Ser His Tyr 
    1850                 1855                 1860             


<210>  2
<211>  1862
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  2

Met Asp Leu Ser Ala Leu Arg Val Glu Glu Val Gln Asn Val Ile Asn 
1               5                   10                  15      


Ala Met Gln Lys Ile Leu Glu Cys Pro Ile Cys Leu Glu Leu Ile Lys 
            20                  25                  30          


Glu Pro Val Ser Thr Lys Cys Asp His Ile Phe Cys Lys Phe Cys Met 
        35                  40                  45              


Leu Lys Leu Leu Asn Gln Lys Lys Gly Pro Ser Gln Cys Pro Leu Cys 
    50                  55                  60                  


Lys Asn Asp Ile Thr Lys Arg Ser Leu Gln Glu Ser Thr Arg Phe Ser 
65                  70                  75                  80  


Gln Leu Val Glu Glu Leu Leu Lys Ile Ile Cys Ala Phe Gln Leu Asp 
                85                  90                  95      


Thr Gly Leu Glu Tyr Ala Asn Ser Tyr Asn Phe Ala Lys Lys Glu Asn 
            100                 105                 110         


Asn Ser Pro Glu His Leu Lys Asp Glu Val Ser Ile Ile Gln Ser Met 
        115                 120                 125             


Gly Tyr Arg Asn Arg Ala Lys Arg Leu Leu Gln Ser Glu Pro Glu Asn 
    130                 135                 140                 


Pro Ser Leu Gln Glu Thr Ser Leu Ser Val Gln Leu Ser Asn Leu Gly 
145                 150                 155                 160 


Thr Val Arg Thr Leu Arg Thr Lys Gln Arg Ile Gln Pro Gln Lys Thr 
                165                 170                 175     


Ser Val Tyr Ile Glu Leu Gly Ser Asp Ser Ser Glu Asp Thr Val Asn 
            180                 185                 190         


Lys Ala Thr Tyr Cys Ser Val Gly Asp Gln Glu Leu Leu Gln Ile Thr 
        195                 200                 205             


Pro Gln Gly Thr Arg Asp Glu Ile Ser Leu Asp Ser Ala Lys Lys Ala 
    210                 215                 220                 


Ala Cys Glu Phe Ser Glu Thr Asp Val Thr Asn Thr Glu His His Gln 
225                 230                 235                 240 


Pro Ser Asn Asn Asp Leu Asn Thr Thr Glu Lys Arg Ala Ala Glu Arg 
                245                 250                 255     


His Pro Glu Lys Tyr Gln Gly Ser Ser Val Ser Asn Leu His Val Glu 
            260                 265                 270         


Pro Cys Gly Thr Asn Thr His Ala Ser Ser Leu Gln His Glu Asn Ser 
        275                 280                 285             


Ser Leu Leu Leu Thr Lys Asp Arg Met Asn Val Glu Lys Ala Glu Phe 
    290                 295                 300                 


Cys Asn Lys Ser Lys Gln Pro Gly Ile Ala Arg Ser Gln His Asn Arg 
305                 310                 315                 320 


Trp Ala Gly Ser Lys Glu Thr Cys Asn Asp Arg Arg Thr Pro Ser Thr 
                325                 330                 335     


Glu Lys Lys Val Asp Leu Asn Ala Asp Pro Leu Cys Glu Arg Lys Glu 
            340                 345                 350         


Trp Asn Lys Gln Lys Leu Pro Cys Ser Glu Asn Pro Arg Asp Thr Glu 
        355                 360                 365             


Asp Val Pro Trp Ile Thr Leu Asn Ser Ser Ile Gln Lys Val Asn Glu 
    370                 375                 380                 


Trp Phe Ser Arg Ser Asp Glu Leu Leu Gly Ser Asp Asp Ser His Asp 
385                 390                 395                 400 


Gly Glu Ser Glu Ser Asn Ala Lys Val Ala Asp Val Leu Asp Val Leu 
                405                 410                 415     


Asn Glu Val Asp Glu Tyr Ser Gly Ser Ser Glu Lys Ile Asp Leu Leu 
            420                 425                 430         


Ala Ser Asp Pro His Glu Ala Leu Ile Cys Lys Ser Glu Arg Val His 
        435                 440                 445             


Ser Lys Ser Val Glu Ser Asn Ile Glu Asp Lys Ile Phe Gly Lys Thr 
    450                 455                 460                 


Tyr Arg Lys Lys Ala Ser Leu Pro Asn Leu Ser His Val Thr Glu Asn 
465                 470                 475                 480 


Leu Ile Ile Gly Ala Phe Val Thr Glu Pro Gln Ile Ile Gln Glu Arg 
                485                 490                 495     


Pro Leu Thr Asn Lys Leu Lys Arg Lys Arg Arg Pro Thr Ser Gly Leu 
            500                 505                 510         


His Pro Glu Asp Phe Ile Lys Lys Ala Asp Leu Ala Val Gln Lys Thr 
        515                 520                 525             


Pro Glu Met Ile Asn Gln Gly Thr Asn Gln Thr Glu Gln Asn Gly Gln 
    530                 535                 540                 


Val Met Asn Ile Thr Asn Ser Gly His Glu Asn Lys Thr Lys Gly Asp 
545                 550                 555                 560 


Ser Ile Gln Asn Glu Lys Asn Pro Asn Pro Ile Glu Ser Leu Glu Lys 
                565                 570                 575     


Glu Ser Ala Phe Lys Thr Lys Ala Glu Pro Ile Ser Ser Ser Ile Ser 
            580                 585                 590         


Asn Met Glu Leu Glu Leu Asn Ile His Asn Ser Lys Ala Pro Lys Lys 
        595                 600                 605             


Asn Arg Leu Arg Arg Lys Ser Ser Thr Arg His Ile His Ala Leu Glu 
    610                 615                 620                 


Leu Val Val Ser Arg Asn Leu Ser Pro Pro Asn Cys Thr Glu Leu Gln 
625                 630                 635                 640 


Ile Asp Ser Cys Ser Ser Ser Glu Glu Ile Lys Lys Lys Lys Tyr Asn 
                645                 650                 655     


Gln Met Pro Val Arg His Ser Arg Asn Leu Gln Leu Met Glu Gly Lys 
            660                 665                 670         


Glu Pro Ala Thr Gly Ala Lys Lys Ser Asn Lys Pro Asn Glu Gln Thr 
        675                 680                 685             


Ser Lys Arg His Asp Ser Asp Thr Phe Pro Glu Leu Lys Leu Thr Asn 
    690                 695                 700                 


Ala Pro Gly Ser Phe Thr Lys Cys Ser Asn Thr Ser Glu Leu Lys Glu 
705                 710                 715                 720 


Phe Val Asn Pro Ser Leu Pro Arg Glu Glu Lys Glu Glu Lys Leu Glu 
                725                 730                 735     


Thr Val Lys Val Ser Asn Asn Ala Glu Asp Pro Lys Asp Leu Met Leu 
            740                 745                 750         


Ser Gly Glu Arg Val Leu Gln Thr Glu Arg Ser Val Glu Ser Ser Ser 
        755                 760                 765             


Ile Ser Leu Val Pro Gly Thr Asp Tyr Gly Thr Gln Glu Ser Ile Ser 
    770                 775                 780                 


Leu Leu Glu Val Ser Thr Leu Gly Lys Ala Lys Thr Glu Pro Asn Lys 
785                 790                 795                 800 


Cys Val Ser Gln Cys Ala Ala Phe Glu Asn Pro Lys Gly Leu Ile His 
                805                 810                 815     


Gly Cys Ser Lys Asp Asn Arg Asn Asp Thr Glu Gly Phe Lys Tyr Pro 
            820                 825                 830         


Leu Gly His Glu Val Asn His Ser Arg Glu Thr Ser Ile Glu Met Glu 
        835                 840                 845             


Glu Ser Glu Leu Asp Ala Gln Tyr Leu Gln Asn Thr Phe Lys Val Ser 
    850                 855                 860                 


Lys Arg Gln Ser Phe Ala Pro Phe Ser Asn Pro Gly Asn Ala Glu Glu 
865                 870                 875                 880 


Glu Cys Ala Thr Phe Ser Ala His Ser Gly Ser Leu Lys Lys Gln Ser 
                885                 890                 895     


Pro Lys Val Thr Phe Glu Cys Glu Gln Lys Glu Glu Asn Gln Gly Lys 
            900                 905                 910         


Asn Glu Ser Asn Ile Lys Pro Val Gln Thr Val Asn Ile Thr Ala Gly 
        915                 920                 925             


Phe Pro Val Val Gly Gln Lys Asp Lys Pro Val Asp Asn Ala Lys Cys 
    930                 935                 940                 


Ser Ile Lys Gly Gly Ser Arg Phe Cys Leu Ser Ser Gln Phe Arg Gly 
945                 950                 955                 960 


Asn Glu Thr Gly Leu Ile Thr Pro Asn Lys His Gly Leu Leu Gln Asn 
                965                 970                 975     


Pro Tyr Arg Ile Pro Pro Leu Phe Pro Ile Lys Ser Phe Val Lys Thr 
            980                 985                 990         


Lys Cys Lys Lys Asn Leu Leu Glu  Glu Asn Phe Glu Glu  His Ser Met 
        995                 1000                 1005             


Ser Pro  Glu Arg Glu Met Gly  Asn Glu Asn Ile Pro  Ser Thr Val 
    1010                 1015                 1020             


Ser Thr  Ile Ser Arg Asn Asn  Ile Arg Glu Asn Val  Phe Lys Glu 
    1025                 1030                 1035             


Ala Ser  Ser Ser Asn Ile Asn  Glu Val Gly Ser Ser  Thr Asn Glu 
    1040                 1045                 1050             


Val Gly  Ser Ser Ile Asn Glu  Ile Gly Ser Ser Asp  Glu Asn Ile 
    1055                 1060                 1065             


Gln Ala  Glu Leu Gly Arg Asn  Arg Gly Pro Lys Leu  Asn Ala Met 
    1070                 1075                 1080             


Leu Arg  Leu Gly Val Leu Gln  Pro Glu Val Tyr Lys  Gln Ser Leu 
    1085                 1090                 1095             


Pro Gly  Ser Asn Cys Lys His  Pro Glu Ile Lys Lys  Gln Glu Tyr 
    1100                 1105                 1110             


Glu Glu  Val Val Gln Thr Val  Asn Thr Asp Phe Ser  Pro Tyr Leu 
    1115                 1120                 1125             


Ile Ser  Asp Asn Leu Glu Gln  Pro Met Gly Ser Ser  His Ala Ser 
    1130                 1135                 1140             


Gln Val  Cys Ser Glu Thr Pro  Asp Asp Leu Leu Asp  Asp Gly Glu 
    1145                 1150                 1155             


Ile Lys  Glu Asp Thr Ser Phe  Ala Glu Asn Asp Ile  Lys Glu Ser 
    1160                 1165                 1170             


Ser Ala  Val Phe Ser Lys Ser  Val Gln Lys Gly Glu  Leu Ser Arg 
    1175                 1180                 1185             


Ser Pro  Ser Pro Phe Thr His  Thr His Leu Ala Gln  Gly Tyr Arg 
    1190                 1195                 1200             


Arg Gly  Ala Lys Lys Leu Glu  Ser Ser Glu Glu Asn  Leu Ser Ser 
    1205                 1210                 1215             


Glu Asp  Glu Glu Leu Pro Cys  Phe Gln His Leu Leu  Phe Gly Lys 
    1220                 1225                 1230             


Val Asn  Asn Ile Pro Ser Gln  Ser Thr Arg His Ser  Thr Val Ala 
    1235                 1240                 1245             


Thr Glu  Cys Leu Ser Lys Asn  Thr Glu Glu Asn Leu  Leu Ser Leu 
    1250                 1255                 1260             


Lys Asn  Ser Leu Asn Asp Cys  Ser Asn Gln Val Ile  Leu Ala Lys 
    1265                 1270                 1275             


Ala Ser  Gln Glu His His Leu  Ser Glu Glu Thr Lys  Cys Ser Ala 
    1280                 1285                 1290             


Ser Leu  Phe Ser Ser Gln Cys  Ser Glu Leu Glu Asp  Leu Thr Ala 
    1295                 1300                 1305             


Asn Thr  Asn Thr Gln Asp Pro  Phe Leu Ile Gly Ser  Ser Lys Gln 
    1310                 1315                 1320             


Met Arg  His Gln Ser Glu Ser  Gln Gly Val Gly Leu  Ser Asp Lys 
    1325                 1330                 1335             


Glu Leu  Val Ser Asp Asp Glu  Glu Gly Gly Thr Gly  Leu Glu Glu 
    1340                 1345                 1350             


Asn Asn  Gln Glu Glu Gln Ser  Met Asp Ser Asn Leu  Gly Glu Ala 
    1355                 1360                 1365             


Ala Ser  Gly Cys Glu Ser Glu  Thr Ser Val Ser Glu  Asp Cys Ser 
    1370                 1375                 1380             


Gly Leu  Ser Ser Gln Ser Asp  Ile Leu Thr Thr Gln  Arg Asp Thr 
    1385                 1390                 1395             


Met Gln  His Asn Leu Ile Lys  Leu Gln Gln Glu Met  Ala Glu Leu 
    1400                 1405                 1410             


Glu Ala  Val Leu Glu Gln His  Gly Ser Gln Pro Ser  Asn Ser Tyr 
    1415                 1420                 1425             


Pro Ser  Ile Ile Ser Asp Ser  Ser Ala Leu Glu Asp  Leu Arg Asn 
    1430                 1435                 1440             


Pro Glu  Gln Ser Thr Ser Glu  Lys Ala Val Leu Thr  Ser Gln Lys 
    1445                 1450                 1455             


Ser Ser  Glu Tyr Pro Ile Ser  Gln Asn Pro Glu Gly  Leu Ser Ala 
    1460                 1465                 1470             


Asp Lys  Phe Glu Val Ser Ala  Asp Ser Ser Thr Ser  Lys Asn Lys 
    1475                 1480                 1485             


Glu Pro  Gly Val Glu Arg Ser  Ser Pro Ser Lys Cys  Pro Ser Leu 
    1490                 1495                 1500             


Asp Asp  Arg Trp Tyr Met His  Ser Cys Ser Gly Ser  Leu Gln Asn 
    1505                 1510                 1515             


Arg Asn  Tyr Pro Ser Gln Glu  Glu Leu Ile Lys Val  Val Asp Val 
    1520                 1525                 1530             


Glu Glu  Gln Gln Leu Glu Glu  Ser Gly Pro His Asp  Leu Thr Glu 
    1535                 1540                 1545             


Thr Ser  Tyr Leu Pro Arg Gln  Asp Leu Glu Gly Thr  Pro Tyr Leu 
    1550                 1555                 1560             


Glu Ser  Gly Ile Ser Leu Phe  Ser Asp Asp Pro Glu  Ser Asp Pro 
    1565                 1570                 1575             


Ser Glu  Asp Arg Ala Pro Glu  Ser Ala Arg Val Gly  Asn Ile Pro 
    1580                 1585                 1590             


Ser Ser  Thr Ser Ala Leu Lys  Val Pro Gln Leu Lys  Val Ala Glu 
    1595                 1600                 1605             


Ser Ala  Gln Ser Pro Ala Ala  Ala His Thr Thr Asp  Thr Ala Gly 
    1610                 1615                 1620             


Tyr Asn  Ala Met Glu Glu Ser  Val Ser Arg Glu Lys  Pro Glu Leu 
    1625                 1630                 1635             


Thr Ala  Ser Thr Glu Arg Val  Asn Lys Arg Met Ser  Met Val Val 
    1640                 1645                 1650             


Ser Gly  Leu Thr Pro Glu Glu  Phe Met Leu Val Tyr  Lys Phe Ala 
    1655                 1660                 1665             


Arg Lys  His His Ile Thr Leu  Thr Asn Leu Ile Thr  Glu Glu Thr 
    1670                 1675                 1680             


Thr His  Val Val Met Lys Thr  Asp Ala Glu Phe Val  Cys Glu Arg 
    1685                 1690                 1695             


Thr Leu  Lys Tyr Phe Leu Gly  Ile Ala Gly Gly Lys  Trp Val Val 
    1700                 1705                 1710             


Ser Tyr  Phe Trp Val Thr Gln  Ser Ile Lys Glu Arg  Lys Met Leu 
    1715                 1720                 1725             


Asn Glu  His Asp Phe Glu Val  Arg Gly Asp Val Val  Asn Gly Arg 
    1730                 1735                 1740             


Asn His  Gln Gly Pro Lys Arg  Ala Arg Glu Ser Gln  Asp Arg Lys 
    1745                 1750                 1755             


Ile Phe  Arg Gly Leu Glu Ile  Cys Cys Tyr Gly Pro  Phe Thr Asn 
    1760                 1765                 1770             


Met Pro  Thr Asp Gln Leu Glu  Trp Met Val Gln Leu  Cys Gly Ala 
    1775                 1780                 1785             


Ser Val  Val Lys Glu Leu Ser  Ser Phe Thr Leu Gly  Thr Gly Val 
    1790                 1795                 1800             


His Pro  Ile Val Val Val Gln  Pro Asp Ala Trp Thr  Glu Asp Asn 
    1805                 1810                 1815             


Gly Phe  His Ala Ile Gly Gln  Met Cys Glu Ala Pro  Val Val Thr 
    1820                 1825                 1830             


Arg Glu  Trp Val Leu Asp Ser  Val Ala Leu Tyr Gln  Cys Gln Glu 
    1835                 1840                 1845             


Leu Asp  Thr Tyr Leu Ile Pro  Gln Ile Pro His Ser  His Tyr 
    1850                 1855                 1860         


<210>  3
<211>  757
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  3

Met Arg Arg Ser Leu Ala Pro Ser Gln Leu Ala Lys Arg Lys Pro Glu 
1               5                   10                  15      


Gly Arg Ser Cys Asp Asp Glu Asp Trp Gln Pro Gly Leu Val Thr Pro 
            20                  25                  30          


Arg Lys Arg Lys Ser Ser Ser Glu Thr Gln Ile Gln Glu Cys Phe Leu 
        35                  40                  45              


Ser Pro Phe Arg Lys Pro Leu Ser Gln Leu Thr Asn Gln Pro Pro Cys 
    50                  55                  60                  


Leu Asp Ser Ser Gln His Glu Ala Phe Ile Arg Ser Ile Leu Ser Lys 
65                  70                  75                  80  


Pro Phe Lys Val Pro Ile Pro Asn Tyr Gln Gly Pro Leu Gly Ser Arg 
                85                  90                  95      


Ala Leu Gly Leu Lys Arg Ala Gly Val Arg Arg Ala Leu His Asp Pro 
            100                 105                 110         


Leu Glu Lys Asp Ala Leu Val Leu Tyr Glu Pro Pro Pro Leu Ser Ala 
        115                 120                 125             


His Asp Gln Leu Lys Leu Asp Lys Glu Lys Leu Pro Val His Val Val 
    130                 135                 140                 


Val Asp Pro Ile Leu Ser Lys Val Leu Arg Pro His Gln Arg Glu Gly 
145                 150                 155                 160 


Val Lys Phe Leu Trp Glu Cys Val Thr Ser Arg Arg Ile Pro Gly Ser 
                165                 170                 175     


His Gly Cys Ile Met Ala Asp Glu Met Gly Leu Gly Lys Thr Leu Gln 
            180                 185                 190         


Cys Ile Thr Leu Met Trp Thr Leu Leu Arg Gln Ser Pro Glu Cys Lys 
        195                 200                 205             


Pro Glu Ile Asp Lys Ala Val Val Val Ser Pro Ser Ser Leu Val Lys 
    210                 215                 220                 


Asn Trp Tyr Asn Glu Val Gly Lys Trp Leu Gly Gly Arg Ile Gln Pro 
225                 230                 235                 240 


Leu Ala Ile Asp Gly Gly Ser Lys Asp Glu Ile Asp Gln Lys Leu Glu 
                245                 250                 255     


Gly Phe Met Asn Gln Arg Gly Ala Arg Val Ser Ser Pro Ile Leu Ile 
            260                 265                 270         


Ile Ser Tyr Glu Thr Phe Arg Leu His Val Gly Val Leu Gln Lys Gly 
        275                 280                 285             


Ser Val Gly Leu Val Ile Cys Asp Glu Gly His Arg Leu Lys Asn Ser 
    290                 295                 300                 


Glu Asn Gln Thr Tyr Gln Ala Leu Asp Ser Leu Asn Thr Ser Arg Arg 
305                 310                 315                 320 


Val Leu Ile Ser Gly Thr Pro Ile Gln Asn Asp Leu Leu Glu Tyr Phe 
                325                 330                 335     


Ser Leu Val His Phe Val Asn Ser Gly Ile Leu Gly Thr Ala His Glu 
            340                 345                 350         


Phe Lys Lys His Phe Glu Leu Pro Ile Leu Lys Gly Arg Asp Ala Ala 
        355                 360                 365             


Ala Ser Glu Ala Asp Arg Gln Leu Gly Glu Glu Arg Leu Arg Glu Leu 
    370                 375                 380                 


Thr Ser Ile Val Asn Arg Cys Leu Ile Arg Arg Thr Ser Asp Ile Leu 
385                 390                 395                 400 


Ser Lys Tyr Leu Pro Val Lys Ile Glu Gln Val Val Cys Cys Arg Leu 
                405                 410                 415     


Thr Pro Leu Gln Thr Glu Leu Tyr Lys Arg Phe Leu Arg Gln Ala Lys 
            420                 425                 430         


Pro Ala Glu Glu Leu Leu Glu Gly Lys Met Ser Val Ser Ser Leu Ser 
        435                 440                 445             


Ser Ile Thr Ser Leu Lys Lys Leu Cys Asn His Pro Ala Leu Ile Tyr 
    450                 455                 460                 


Asp Lys Cys Val Glu Glu Glu Asp Gly Phe Val Gly Ala Leu Asp Leu 
465                 470                 475                 480 


Phe Pro Pro Gly Tyr Ser Ser Lys Ala Leu Glu Pro Gln Leu Ser Val 
                485                 490                 495     


Gly Asp Cys Trp Leu Leu Leu Phe Pro Gly Lys Met Leu Val Leu Asp 
            500                 505                 510         


Tyr Ile Leu Ala Val Thr Arg Ser Arg Ser Ser Asp Lys Val Val Leu 
        515                 520                 525             


Val Ser Asn Tyr Thr Gln Thr Leu Asp Leu Phe Glu Lys Leu Cys Arg 
    530                 535                 540                 


Ala Arg Arg Tyr Leu Tyr Val Arg Leu Asp Gly Thr Met Ser Ile Lys 
545                 550                 555                 560 


Lys Arg Ala Lys Val Val Glu Arg Phe Asn Ser Pro Ser Ser Pro Asp 
                565                 570                 575     


Phe Val Phe Met Leu Ser Ser Lys Ala Gly Gly Cys Gly Leu Asn Leu 
            580                 585                 590         


Ile Gly Ala Asn Arg Leu Val Met Phe Asp Pro Asp Trp Asn Pro Ala 
        595                 600                 605             


Asn Asp Glu Gln Ala Met Ala Arg Val Trp Arg Asp Gly Gln Lys Lys 
    610                 615                 620                 


Thr Cys Tyr Ile Tyr Arg Leu Leu Ser Ala Gly Thr Ile Glu Glu Lys 
625                 630                 635                 640 


Ile Phe Gln Arg Gln Ser His Lys Lys Ala Leu Ser Ser Cys Val Val 
                645                 650                 655     


Asp Glu Glu Gln Asp Val Glu Arg His Phe Ser Leu Gly Glu Leu Lys 
            660                 665                 670         


Glu Leu Phe Ile Leu Asp Glu Ala Ser Leu Ser Asp Thr His Asp Arg 
        675                 680                 685             


Leu His Cys Arg Arg Cys Val Asn Ser Arg Gln Ile Arg Pro Pro Pro 
    690                 695                 700                 


Asp Gly Ser Asp Cys Thr Ser Asp Leu Ala Gly Trp Asn His Cys Thr 
705                 710                 715                 720 


Asp Lys Trp Gly Leu Arg Asp Glu Val Leu Gln Ala Ala Trp Asp Ala 
                725                 730                 735     


Ala Ser Thr Ala Ile Thr Phe Val Phe His Gln Arg Ser His Glu Glu 
            740                 745                 750         


Gln Arg Gly Leu Arg 
        755         


<210>  4
<211>  897
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  4

Met Asn Ile Ser Gly Ser Ser Cys Gly Ser Pro Asn Ser Ala Asp Thr 
1               5                   10                  15      


Ser Ser Asp Phe Lys Asp Leu Trp Thr Lys Leu Lys Glu Cys His Asp 
            20                  25                  30          


Arg Glu Val Gln Gly Leu Gln Val Lys Val Thr Lys Leu Lys Gln Glu 
        35                  40                  45              


Arg Ile Leu Asp Ala Gln Arg Leu Glu Glu Phe Phe Thr Lys Asn Gln 
    50                  55                  60                  


Gln Leu Arg Glu Gln Gln Lys Val Leu His Glu Thr Ile Lys Val Leu 
65                  70                  75                  80  


Glu Asp Arg Leu Arg Ala Gly Leu Cys Asp Arg Cys Ala Val Thr Glu 
                85                  90                  95      


Glu His Met Arg Lys Lys Gln Gln Glu Phe Glu Asn Ile Arg Gln Gln 
            100                 105                 110         


Asn Leu Lys Leu Ile Thr Glu Leu Met Asn Glu Arg Asn Thr Leu Gln 
        115                 120                 125             


Glu Glu Asn Lys Lys Leu Ser Glu Gln Leu Gln Gln Lys Ile Glu Asn 
    130                 135                 140                 


Asp Gln Gln His Gln Ala Ala Glu Leu Glu Cys Glu Glu Asp Val Ile 
145                 150                 155                 160 


Pro Asp Ser Pro Ile Thr Ala Phe Ser Phe Ser Gly Val Asn Arg Leu 
                165                 170                 175     


Arg Arg Lys Glu Asn Pro His Val Arg Tyr Ile Glu Gln Thr His Thr 
            180                 185                 190         


Lys Leu Glu His Ser Val Cys Ala Asn Glu Met Arg Lys Val Ser Lys 
        195                 200                 205             


Ser Ser Thr His Pro Gln His Asn Pro Asn Glu Asn Glu Ile Leu Val 
    210                 215                 220                 


Ala Asp Thr Tyr Asp Gln Ser Gln Ser Pro Met Ala Lys Ala His Gly 
225                 230                 235                 240 


Thr Ser Ser Tyr Thr Pro Asp Lys Ser Ser Phe Asn Leu Ala Thr Val 
                245                 250                 255     


Val Ala Glu Thr Leu Gly Leu Gly Val Gln Glu Glu Ser Glu Thr Gln 
            260                 265                 270         


Gly Pro Met Ser Pro Leu Gly Asp Glu Leu Tyr His Cys Leu Glu Gly 
        275                 280                 285             


Asn His Lys Lys Gln Pro Phe Glu Glu Ser Thr Arg Asn Thr Glu Asp 
    290                 295                 300                 


Ser Leu Arg Phe Ser Asp Ser Thr Ser Lys Thr Pro Pro Gln Glu Glu 
305                 310                 315                 320 


Leu Pro Thr Arg Val Ser Ser Pro Val Phe Gly Ala Thr Ser Ser Ile 
                325                 330                 335     


Lys Ser Gly Leu Asp Leu Asn Thr Ser Leu Ser Pro Ser Leu Leu Gln 
            340                 345                 350         


Pro Gly Lys Lys Lys His Leu Lys Thr Leu Pro Phe Ser Asn Thr Cys 
        355                 360                 365             


Ile Ser Arg Leu Glu Lys Thr Arg Ser Lys Ser Glu Asp Ser Ala Leu 
    370                 375                 380                 


Phe Thr His His Ser Leu Gly Ser Glu Val Asn Lys Ile Ile Ile Gln 
385                 390                 395                 400 


Ser Ser Asn Lys Gln Ile Leu Ile Asn Lys Asn Ile Ser Glu Ser Leu 
                405                 410                 415     


Gly Glu Gln Asn Arg Thr Glu Tyr Gly Lys Asp Ser Asn Thr Asp Lys 
            420                 425                 430         


His Leu Glu Pro Leu Lys Ser Leu Gly Gly Arg Thr Ser Lys Arg Lys 
        435                 440                 445             


Lys Thr Glu Glu Glu Ser Glu His Glu Val Ser Cys Pro Gln Ala Ser 
    450                 455                 460                 


Phe Asp Lys Glu Asn Ala Phe Pro Phe Pro Met Asp Asn Gln Phe Ser 
465                 470                 475                 480 


Met Asn Gly Asp Cys Val Met Asp Lys Pro Leu Asp Leu Ser Asp Arg 
                485                 490                 495     


Phe Ser Ala Ile Gln Arg Gln Glu Lys Ser Gln Gly Ser Glu Thr Ser 
            500                 505                 510         


Lys Asn Lys Phe Arg Gln Val Thr Leu Tyr Glu Ala Leu Lys Thr Ile 
        515                 520                 525             


Pro Lys Gly Phe Ser Ser Ser Arg Lys Ala Ser Asp Gly Asn Cys Thr 
    530                 535                 540                 


Leu Pro Lys Asp Ser Pro Gly Glu Pro Cys Ser Gln Glu Cys Ile Ile 
545                 550                 555                 560 


Leu Gln Pro Leu Asn Lys Cys Ser Pro Asp Asn Lys Pro Ser Leu Gln 
                565                 570                 575     


Ile Lys Glu Glu Asn Ala Val Phe Lys Ile Pro Leu Arg Pro Arg Glu 
            580                 585                 590         


Ser Leu Glu Thr Glu Asn Val Leu Asp Asp Ile Lys Ser Ala Gly Ser 
        595                 600                 605             


His Glu Pro Ile Lys Ile Gln Thr Arg Ser Asp His Gly Gly Cys Glu 
    610                 615                 620                 


Leu Ala Ser Val Leu Gln Leu Asn Pro Cys Arg Thr Gly Lys Ile Lys 
625                 630                 635                 640 


Ser Leu Gln Asn Asn Gln Asp Val Ser Phe Glu Asn Ile Gln Trp Ser 
                645                 650                 655     


Ile Asp Pro Gly Ala Asp Leu Ser Gln Tyr Lys Met Asp Val Thr Val 
            660                 665                 670         


Ile Asp Thr Lys Asp Gly Ser Gln Ser Lys Leu Gly Gly Glu Thr Val 
        675                 680                 685             


Asp Met Asp Cys Thr Leu Val Ser Glu Thr Val Leu Leu Lys Met Lys 
    690                 695                 700                 


Lys Gln Glu Gln Lys Gly Glu Lys Ser Ser Asn Glu Glu Arg Lys Met 
705                 710                 715                 720 


Asn Asp Ser Leu Glu Asp Met Phe Asp Arg Thr Thr His Glu Glu Tyr 
                725                 730                 735     


Glu Ser Cys Leu Ala Asp Ser Phe Ser Gln Ala Ala Asp Glu Glu Glu 
            740                 745                 750         


Glu Leu Ser Thr Ala Thr Lys Lys Leu His Thr His Gly Asp Lys Gln 
        755                 760                 765             


Asp Lys Val Lys Gln Lys Ala Phe Val Glu Pro Tyr Phe Lys Gly Asp 
    770                 775                 780                 


Glu Arg Glu Thr Ser Leu Gln Asn Phe Pro His Ile Glu Val Val Arg 
785                 790                 795                 800 


Lys Lys Glu Glu Arg Arg Lys Leu Leu Gly His Thr Cys Lys Glu Cys 
                805                 810                 815     


Glu Ile Tyr Tyr Ala Asp Met Pro Ala Glu Glu Arg Glu Lys Lys Leu 
            820                 825                 830         


Ala Ser Cys Ser Arg His Arg Phe Arg Tyr Ile Pro Pro Asn Glu Pro 
        835                 840                 845             


Glu Asn Phe Trp Glu Val Gly Phe Pro Ser Thr Gln Thr Cys Met Glu 
    850                 855                 860                 


Arg Gly Tyr Ile Lys Glu Asp Leu Asp Pro Cys Pro Arg Pro Lys Arg 
865                 870                 875                 880 


Arg Gln Pro Tyr Asn Ala Ile Phe Ser Pro Lys Gly Lys Glu Gln Lys 
                885                 890                 895     


Thr 
    


<210>  5
<211>  1186
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  5

Met Asp Glu Pro Pro Gly Lys Pro Leu Ser Cys Glu Glu Arg Glu Arg 
1               5                   10                  15      


Leu Arg Glu Arg Leu Ala Phe Leu Arg Arg Glu Tyr Ser Arg Thr Leu 
            20                  25                  30          


Ala Arg Leu Gln Arg Ala Gln Arg Ala Glu Arg Ile Arg His Ser Ile 
        35                  40                  45              


Lys Lys Thr Val Glu Glu Gln Asp Cys Leu Ser Gln Gln Asp Leu Ser 
    50                  55                  60                  


Pro Gln Leu Lys His Ser Glu Pro Lys Asn Lys Ile Cys Val Tyr Asp 
65                  70                  75                  80  


Lys Leu His Ile Lys Thr His Leu Asp Glu Glu Thr Gly Glu Lys Thr 
                85                  90                  95      


Ser Ile Thr Leu Asp Val Gly Pro Glu Ser Phe Asn Pro Gly Asp Gly 
            100                 105                 110         


Pro Gly Gly Leu Pro Ile Gln Arg Thr Asp Asp Thr Gln Glu His Phe 
        115                 120                 125             


Pro His Arg Val Ser Asp Pro Ser Gly Glu Gln Lys Gln Lys Leu Pro 
    130                 135                 140                 


Ser Arg Arg Lys Lys Gln Gln Lys Arg Thr Phe Ile Ser Gln Glu Arg 
145                 150                 155                 160 


Asp Cys Val Phe Gly Thr Asp Ser Leu Arg Leu Ser Gly Lys Arg Leu 
                165                 170                 175     


Lys Glu Gln Glu Glu Ile Ser Ser Lys Asn Pro Ala Arg Ser Pro Val 
            180                 185                 190         


Thr Glu Ile Arg Thr His Leu Leu Ser Leu Lys Ser Glu Leu Pro Asp 
        195                 200                 205             


Ser Pro Glu Pro Val Thr Glu Ile Asn Glu Asp Ser Val Leu Ile Pro 
    210                 215                 220                 


Pro Thr Ala Gln Pro Glu Lys Gly Val Asp Thr Phe Leu Arg Arg Pro 
225                 230                 235                 240 


Asn Phe Thr Arg Ala Thr Thr Val Pro Leu Gln Thr Leu Ser Asp Ser 
                245                 250                 255     


Gly Ser Ser Gln His Leu Glu His Ile Pro Pro Lys Gly Ser Ser Glu 
            260                 265                 270         


Leu Thr Thr His Asp Leu Lys Asn Ile Arg Phe Thr Ser Pro Val Ser 
        275                 280                 285             


Leu Glu Ala Gln Gly Lys Lys Met Thr Val Ser Thr Asp Asn Leu Leu 
    290                 295                 300                 


Val Asn Lys Ala Ile Ser Lys Ser Gly Gln Leu Pro Thr Ser Ser Asn 
305                 310                 315                 320 


Leu Glu Ala Asn Ile Ser Cys Ser Leu Asn Glu Leu Thr Tyr Asn Asn 
                325                 330                 335     


Leu Pro Ala Asn Glu Asn Gln Asn Leu Lys Glu Gln Asn Gln Thr Glu 
            340                 345                 350         


Lys Ser Leu Lys Ser Pro Ser Asp Thr Leu Asp Gly Arg Asn Glu Asn 
        355                 360                 365             


Leu Gln Glu Ser Glu Ile Leu Ser Gln Pro Lys Ser Leu Ser Leu Glu 
    370                 375                 380                 


Ala Thr Ser Pro Leu Ser Ala Glu Lys His Ser Cys Thr Val Pro Glu 
385                 390                 395                 400 


Gly Leu Leu Phe Pro Ala Glu Tyr Tyr Val Arg Thr Thr Arg Ser Met 
                405                 410                 415     


Ser Asn Cys Gln Arg Lys Val Ala Val Glu Ala Val Ile Gln Ser His 
            420                 425                 430         


Leu Asp Val Lys Lys Lys Gly Phe Lys Asn Lys Asn Lys Asp Ala Ser 
        435                 440                 445             


Lys Asn Leu Asn Leu Ser Asn Glu Glu Thr Asp Gln Ser Glu Ile Arg 
    450                 455                 460                 


Met Ser Gly Thr Cys Thr Gly Gln Pro Ser Ser Arg Thr Ser Gln Lys 
465                 470                 475                 480 


Leu Leu Ser Leu Thr Lys Val Ser Ser Pro Ala Gly Pro Thr Glu Asp 
                485                 490                 495     


Asn Asp Leu Ser Arg Lys Ala Val Ala Gln Ala Pro Gly Arg Arg Tyr 
            500                 505                 510         


Thr Gly Lys Arg Lys Ser Ala Cys Thr Pro Ala Ser Asp His Cys Glu 
        515                 520                 525             


Pro Leu Leu Pro Thr Ser Ser Leu Ser Ile Val Asn Arg Ser Lys Glu 
    530                 535                 540                 


Glu Val Thr Ser His Lys Tyr Gln His Glu Lys Leu Phe Ile Gln Val 
545                 550                 555                 560 


Lys Gly Lys Lys Ser Arg His Gln Lys Glu Asp Ser Leu Ser Trp Ser 
                565                 570                 575     


Asn Ser Ala Tyr Leu Ser Leu Asp Asp Asp Ala Phe Thr Ala Pro Phe 
            580                 585                 590         


His Arg Asp Gly Met Leu Ser Leu Lys Gln Leu Leu Ser Phe Leu Ser 
        595                 600                 605             


Ile Thr Asp Phe Gln Leu Pro Asp Glu Asp Phe Gly Pro Leu Lys Leu 
    610                 615                 620                 


Glu Lys Val Lys Ser Cys Ser Glu Lys Pro Val Glu Pro Phe Glu Ser 
625                 630                 635                 640 


Lys Met Phe Gly Glu Arg His Leu Lys Glu Gly Ser Cys Ile Phe Pro 
                645                 650                 655     


Glu Glu Leu Ser Pro Lys Arg Met Asp Thr Glu Met Glu Asp Leu Glu 
            660                 665                 670         


Glu Asp Leu Ile Val Leu Pro Gly Lys Ser His Pro Lys Arg Pro Asn 
        675                 680                 685             


Ser Gln Ser Gln His Thr Lys Thr Gly Leu Ser Ser Ser Ile Leu Leu 
    690                 695                 700                 


Tyr Thr Pro Leu Asn Thr Val Ala Pro Asp Asp Asn Asp Arg Pro Thr 
705                 710                 715                 720 


Thr Asp Met Cys Ser Pro Ala Phe Pro Ile Leu Gly Thr Thr Pro Ala 
                725                 730                 735     


Phe Gly Pro Gln Gly Ser Tyr Glu Lys Ala Ser Thr Glu Val Ala Gly 
            740                 745                 750         


Arg Thr Cys Cys Thr Pro Gln Leu Ala His Leu Lys Asp Ser Val Cys 
        755                 760                 765             


Leu Ala Ser Asp Thr Lys Gln Phe Asp Ser Ser Gly Ser Pro Ala Lys 
    770                 775                 780                 


Pro His Thr Thr Leu Gln Val Ser Gly Arg Gln Gly Gln Pro Thr Cys 
785                 790                 795                 800 


Asp Cys Asp Ser Val Pro Pro Gly Thr Pro Pro Pro Ile Glu Ser Phe 
                805                 810                 815     


Thr Phe Lys Glu Asn Gln Leu Cys Arg Asn Thr Cys Gln Glu Leu His 
            820                 825                 830         


Lys His Ser Val Glu Gln Thr Glu Thr Ala Glu Leu Pro Ala Ser Asp 
        835                 840                 845             


Ser Ile Asn Pro Gly Asn Leu Gln Leu Val Ser Glu Leu Lys Asn Pro 
    850                 855                 860                 


Ser Gly Ser Cys Ser Val Asp Val Ser Ala Met Phe Trp Glu Arg Ala 
865                 870                 875                 880 


Gly Cys Lys Glu Pro Cys Ile Ile Thr Ala Cys Glu Asp Val Val Ser 
                885                 890                 895     


Leu Trp Lys Ala Leu Asp Ala Trp Gln Trp Glu Lys Leu Tyr Thr Trp 
            900                 905                 910         


His Phe Ala Glu Val Pro Val Leu Gln Ile Val Pro Val Pro Asp Val 
        915                 920                 925             


Tyr Asn Leu Val Cys Val Ala Leu Gly Asn Leu Glu Ile Arg Glu Ile 
    930                 935                 940                 


Arg Ala Leu Phe Cys Ser Ser Asp Asp Glu Ser Glu Lys Gln Val Leu 
945                 950                 955                 960 


Leu Lys Ser Gly Asn Ile Lys Ala Val Leu Gly Leu Thr Lys Arg Arg 
                965                 970                 975     


Leu Val Ser Ser Ser Gly Thr Leu Ser Asp Gln Gln Val Glu Val Met 
            980                 985                 990         


Thr Phe Ala Glu Asp Gly Gly Gly  Lys Glu Asn Gln Phe  Leu Met Pro 
        995                 1000                 1005             


Pro Glu  Glu Thr Ile Leu Thr  Phe Ala Glu Val Gln  Gly Met Gln 
    1010                 1015                 1020             


Glu Ala  Leu Leu Gly Thr Thr  Ile Met Asn Asn Ile  Val Ile Trp 
    1025                 1030                 1035             


Asn Leu  Lys Thr Gly Gln Leu  Leu Lys Lys Met His  Ile Asp Asp 
    1040                 1045                 1050             


Ser Tyr  Gln Ala Ser Val Cys  His Lys Ala Tyr Ser  Glu Met Gly 
    1055                 1060                 1065             


Leu Leu  Phe Ile Val Leu Ser  His Pro Cys Ala Lys  Glu Ser Glu 
    1070                 1075                 1080             


Ser Leu  Arg Ser Pro Val Phe  Gln Leu Ile Val Ile  Asn Pro Lys 
    1085                 1090                 1095             


Thr Thr  Leu Ser Val Gly Val  Met Leu Tyr Cys Leu  Pro Pro Gly 
    1100                 1105                 1110             


Gln Ala  Gly Arg Phe Leu Glu  Gly Asp Val Lys Asp  His Cys Ala 
    1115                 1120                 1125             


Ala Ala  Ile Leu Thr Ser Gly  Thr Ile Ala Ile Trp  Asp Leu Leu 
    1130                 1135                 1140             


Leu Gly  Gln Cys Thr Ala Leu  Leu Pro Pro Val Ser  Asp Gln His 
    1145                 1150                 1155             


Trp Ser  Phe Val Lys Trp Ser  Gly Thr Asp Ser His  Leu Leu Ala 
    1160                 1165                 1170             


Gly Gln  Lys Asp Gly Asn Ile  Phe Val Tyr His Tyr  Ser 
    1175                 1180                 1185     


<210>  6
<211>  339
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  6

Met Ala Met Gln Met Gln Leu Glu Ala Asn Ala Asp Thr Ser Val Glu 
1               5                   10                  15      


Glu Glu Ser Phe Gly Pro Gln Pro Ile Ser Arg Leu Glu Gln Cys Gly 
            20                  25                  30          


Ile Asn Ala Asn Asp Val Lys Lys Leu Glu Glu Ala Gly Phe His Thr 
        35                  40                  45              


Val Glu Ala Val Ala Tyr Ala Pro Lys Lys Glu Leu Ile Asn Ile Lys 
    50                  55                  60                  


Gly Ile Ser Glu Ala Lys Ala Asp Lys Ile Leu Ala Glu Ala Ala Lys 
65                  70                  75                  80  


Leu Val Pro Met Gly Phe Thr Thr Ala Thr Glu Phe His Gln Arg Arg 
                85                  90                  95      


Ser Glu Ile Ile Gln Ile Thr Thr Gly Ser Lys Glu Leu Asp Lys Leu 
            100                 105                 110         


Leu Gln Gly Gly Ile Glu Thr Gly Ser Ile Thr Glu Met Phe Gly Glu 
        115                 120                 125             


Phe Arg Thr Gly Lys Thr Gln Ile Cys His Thr Leu Ala Val Thr Cys 
    130                 135                 140                 


Gln Leu Pro Ile Asp Arg Gly Gly Gly Glu Gly Lys Ala Met Tyr Ile 
145                 150                 155                 160 


Asp Thr Glu Gly Thr Phe Arg Pro Glu Arg Leu Leu Ala Val Ala Glu 
                165                 170                 175     


Arg Tyr Gly Leu Ser Gly Ser Asp Val Leu Asp Asn Val Ala Tyr Ala 
            180                 185                 190         


Arg Ala Phe Asn Thr Asp His Gln Thr Gln Leu Leu Tyr Gln Ala Ser 
        195                 200                 205             


Ala Met Met Val Glu Ser Arg Tyr Ala Leu Leu Ile Val Asp Ser Ala 
    210                 215                 220                 


Thr Ala Leu Tyr Arg Thr Asp Tyr Ser Gly Arg Gly Glu Leu Ser Ala 
225                 230                 235                 240 


Arg Gln Met His Leu Ala Arg Phe Leu Arg Met Leu Leu Arg Leu Ala 
                245                 250                 255     


Asp Glu Phe Gly Val Ala Val Val Ile Thr Asn Gln Val Val Ala Gln 
            260                 265                 270         


Val Asp Gly Ala Ala Met Phe Ala Ala Asp Pro Lys Lys Pro Ile Gly 
        275                 280                 285             


Gly Asn Ile Ile Ala His Ala Ser Thr Thr Arg Leu Tyr Leu Arg Lys 
    290                 295                 300                 


Gly Arg Gly Glu Thr Arg Ile Cys Lys Ile Tyr Asp Ser Pro Cys Leu 
305                 310                 315                 320 


Pro Glu Ala Glu Ala Met Phe Ala Ile Asn Ala Asp Gly Val Gly Asp 
                325                 330                 335     


Ala Lys Asp 
            


<210>  7
<211>  346
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  7

Met Asp Leu Asp Leu Leu Asp Leu Asn Pro Arg Ile Ile Ala Ala Ile 
1               5                   10                  15      


Lys Lys Ala Lys Leu Lys Ser Val Lys Glu Val Leu His Phe Ser Gly 
            20                  25                  30          


Pro Asp Leu Lys Arg Leu Thr Asn Leu Ser Ser Pro Glu Val Trp His 
        35                  40                  45              


Leu Leu Arg Thr Ala Ser Leu His Leu Arg Gly Ser Ser Ile Leu Thr 
    50                  55                  60                  


Ala Leu Gln Leu His Gln Gln Lys Glu Arg Phe Pro Thr Gln His Gln 
65                  70                  75                  80  


Arg Leu Ser Leu Gly Cys Pro Val Leu Asp Ala Leu Leu Arg Gly Gly 
                85                  90                  95      


Leu Pro Leu Asp Gly Ile Thr Glu Leu Ala Gly Arg Ser Ser Ala Gly 
            100                 105                 110         


Lys Thr Gln Leu Ala Leu Gln Leu Cys Leu Ala Val Gln Phe Pro Arg 
        115                 120                 125             


Gln His Gly Gly Leu Glu Ala Gly Ala Val Tyr Ile Cys Thr Glu Asp 
    130                 135                 140                 


Ala Phe Pro His Lys Arg Leu Gln Gln Leu Met Ala Gln Gln Pro Arg 
145                 150                 155                 160 


Leu Arg Thr Asp Val Pro Gly Glu Leu Leu Gln Lys Leu Arg Phe Gly 
                165                 170                 175     


Ser Gln Ile Phe Ile Glu His Val Ala Asp Val Asp Thr Leu Leu Glu 
            180                 185                 190         


Cys Val Asn Lys Lys Val Pro Val Leu Leu Ser Arg Gly Met Ala Arg 
        195                 200                 205             


Leu Val Val Ile Asp Ser Val Ala Ala Pro Phe Arg Cys Glu Phe Asp 
    210                 215                 220                 


Ser Gln Ala Ser Ala Pro Arg Ala Arg His Leu Gln Ser Leu Gly Ala 
225                 230                 235                 240 


Thr Leu Arg Glu Leu Ser Ser Ala Phe Gln Ser Pro Val Leu Cys Ile 
                245                 250                 255     


Asn Gln Val Thr Glu Ala Met Glu Glu Gln Gly Ala Ala His Gly Pro 
            260                 265                 270         


Leu Gly Phe Trp Asp Glu Arg Val Ser Pro Ala Leu Gly Ile Thr Trp 
        275                 280                 285             


Ala Asn Gln Leu Leu Val Arg Leu Leu Ala Asp Arg Leu Arg Glu Glu 
    290                 295                 300                 


Glu Ala Ala Leu Gly Cys Pro Ala Arg Thr Leu Arg Val Leu Ser Ala 
305                 310                 315                 320 


Pro His Leu Pro Pro Ser Ser Cys Ser Tyr Thr Ile Ser Ala Glu Gly 
                325                 330                 335     


Val Arg Gly Thr Pro Gly Thr Gln Ser His 
            340                 345     


<210>  8
<211>  991
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  8

Met Ser Ser His His Thr Thr Phe Pro Phe Asp Pro Glu Arg Arg Val 
1               5                   10                  15      


Arg Ser Thr Leu Lys Lys Val Phe Gly Phe Asp Ser Phe Lys Thr Pro 
            20                  25                  30          


Leu Gln Glu Ser Ala Thr Met Ala Val Val Lys Gly Asn Lys Asp Val 
        35                  40                  45              


Phe Val Cys Met Pro Thr Gly Ala Gly Lys Ser Leu Cys Tyr Gln Leu 
    50                  55                  60                  


Pro Ala Leu Leu Ala Lys Gly Ile Thr Ile Val Val Ser Pro Leu Ile 
65                  70                  75                  80  


Ala Leu Ile Gln Asp Gln Val Asp His Leu Leu Thr Leu Lys Val Arg 
                85                  90                  95      


Val Ser Ser Leu Asn Ser Lys Leu Ser Ala Gln Glu Arg Lys Glu Leu 
            100                 105                 110         


Leu Ala Asp Leu Glu Arg Glu Lys Pro Gln Thr Lys Ile Leu Tyr Ile 
        115                 120                 125             


Thr Pro Glu Met Ala Ala Ser Ser Ser Phe Gln Pro Thr Leu Asn Ser 
    130                 135                 140                 


Leu Val Ser Arg His Leu Leu Ser Tyr Leu Val Val Asp Glu Ala His 
145                 150                 155                 160 


Cys Val Ser Gln Trp Gly His Asp Phe Arg Pro Asp Tyr Leu Arg Leu 
                165                 170                 175     


Gly Ala Leu Arg Ser Arg Leu Gly His Ala Pro Cys Val Ala Leu Thr 
            180                 185                 190         


Ala Thr Ala Thr Pro Gln Val Gln Glu Asp Val Phe Ala Ala Leu His 
        195                 200                 205             


Leu Lys Lys Pro Val Ala Ile Phe Lys Thr Pro Cys Phe Arg Ala Asn 
    210                 215                 220                 


Leu Phe Tyr Asp Val Gln Phe Lys Glu Leu Ile Ser Asp Pro Tyr Gly 
225                 230                 235                 240 


Asn Leu Lys Asp Phe Cys Leu Lys Ala Leu Gly Gln Glu Ala Asp Lys 
                245                 250                 255     


Gly Leu Ser Gly Cys Gly Ile Val Tyr Cys Arg Thr Arg Glu Ala Cys 
            260                 265                 270         


Glu Gln Leu Ala Ile Glu Leu Ser Cys Arg Gly Val Asn Ala Lys Ala 
        275                 280                 285             


Tyr His Ala Gly Leu Lys Ala Ser Glu Arg Thr Leu Val Gln Asn Asp 
    290                 295                 300                 


Trp Met Glu Glu Lys Val Pro Val Ile Val Ala Thr Ile Ser Phe Gly 
305                 310                 315                 320 


Met Gly Val Asp Lys Ala Asn Val Arg Phe Val Ala His Trp Asn Ile 
                325                 330                 335     


Ala Lys Ser Met Ala Gly Tyr Tyr Gln Glu Ser Gly Arg Ala Gly Arg 
            340                 345                 350         


Asp Gly Lys Pro Ser Trp Cys Arg Leu Tyr Tyr Ser Arg Asn Asp Arg 
        355                 360                 365             


Asp Gln Val Ser Phe Leu Ile Arg Lys Glu Val Ala Lys Leu Gln Glu 
    370                 375                 380                 


Lys Arg Gly Asn Lys Ala Ser Asp Lys Ala Thr Ile Met Ala Phe Asp 
385                 390                 395                 400 


Ala Leu Val Thr Phe Cys Glu Glu Leu Gly Cys Arg His Ala Ala Ile 
                405                 410                 415     


Ala Lys Tyr Phe Gly Asp Ala Leu Pro Ala Cys Ala Lys Gly Cys Asp 
            420                 425                 430         


His Cys Gln Asn Pro Thr Ala Val Arg Arg Arg Leu Glu Ala Leu Glu 
        435                 440                 445             


Arg Ser Ser Ser Trp Ser Lys Thr Cys Ile Gly Pro Ser Gln Gly Asn 
    450                 455                 460                 


Gly Phe Asp Pro Glu Leu Tyr Glu Gly Gly Arg Lys Gly Tyr Gly Asp 
465                 470                 475                 480 


Phe Ser Arg Tyr Asp Glu Gly Ser Gly Gly Ser Gly Asp Glu Gly Arg 
                485                 490                 495     


Asp Glu Ala His Lys Arg Glu Trp Asn Leu Phe Tyr Gln Lys Gln Met 
            500                 505                 510         


Gln Leu Arg Lys Gly Lys Asp Pro Lys Ile Glu Glu Phe Val Pro Pro 
        515                 520                 525             


Asp Glu Asn Cys Pro Leu Lys Glu Ala Ser Ser Arg Arg Ile Pro Arg 
    530                 535                 540                 


Leu Thr Val Lys Ala Arg Glu His Cys Leu Arg Leu Leu Glu Glu Ala 
545                 550                 555                 560 


Leu Ser Ser Asn Arg Gln Ser Thr Arg Thr Ala Asp Glu Ala Asp Leu 
                565                 570                 575     


Arg Ala Lys Ala Val Glu Leu Glu His Glu Thr Phe Arg Asn Ala Lys 
            580                 585                 590         


Val Ala Asn Leu Tyr Lys Ala Ser Val Leu Lys Lys Val Ala Asp Ile 
        595                 600                 605             


His Arg Ala Ser Lys Asp Gly Gln Pro Tyr Asp Met Gly Gly Ser Ala 
    610                 615                 620                 


Lys Ser Cys Ser Ala Gln Ala Glu Pro Pro Glu Pro Asn Glu Tyr Asp 
625                 630                 635                 640 


Ile Pro Pro Ala Ser His Val Tyr Ser Leu Lys Pro Lys Arg Val Gly 
                645                 650                 655     


Ala Gly Phe Pro Lys Gly Ser Cys Pro Phe Gln Thr Ala Thr Glu Leu 
            660                 665                 670         


Met Glu Thr Thr Arg Ile Arg Glu Gln Ala Pro Gln Pro Glu Arg Gly 
        675                 680                 685             


Gly Glu His Glu Pro Pro Ser Arg Pro Cys Gly Leu Leu Asp Glu Asp 
    690                 695                 700                 


Gly Ser Glu Pro Leu Pro Gly Pro Arg Gly Glu Val Pro Gly Gly Ser 
705                 710                 715                 720 


Ala His Tyr Gly Gly Pro Ser Pro Glu Lys Lys Ala Lys Ser Ser Ser 
                725                 730                 735     


Gly Gly Ser Ser Leu Ala Lys Gly Arg Ala Ser Lys Lys Gln Gln Leu 
            740                 745                 750         


Leu Ala Thr Ala Ala His Lys Asp Ser Gln Ser Ile Ala Arg Phe Phe 
        755                 760                 765             


Cys Arg Arg Val Glu Ser Pro Ala Leu Leu Ala Ser Ala Pro Glu Ala 
    770                 775                 780                 


Glu Gly Ala Cys Pro Ser Cys Glu Gly Val Gln Gly Pro Pro Met Ala 
785                 790                 795                 800 


Pro Glu Lys Tyr Thr Gly Glu Glu Asp Gly Ala Gly Gly His Ser Pro 
                805                 810                 815     


Ala Pro Pro Gln Thr Glu Glu Cys Leu Arg Glu Arg Pro Ser Thr Cys 
            820                 825                 830         


Pro Pro Arg Asp Gln Gly Thr Pro Glu Val Gln Pro Thr Pro Ala Lys 
        835                 840                 845             


Asp Thr Trp Lys Gly Lys Arg Pro Arg Ser Gln Gln Glu Asn Pro Glu 
    850                 855                 860                 


Ser Gln Pro Gln Lys Arg Pro Arg Pro Ser Ala Lys Pro Ser Val Val 
865                 870                 875                 880 


Ala Glu Val Lys Gly Ser Val Ser Ala Ser Glu Gln Gly Thr Leu Asn 
                885                 890                 895     


Pro Thr Ala Gln Asp Pro Phe Gln Leu Ser Ala Pro Gly Val Ser Leu 
            900                 905                 910         


Lys Glu Ala Ala Asn Val Val Val Lys Cys Leu Thr Pro Phe Tyr Lys 
        915                 920                 925             


Glu Gly Lys Phe Ala Ser Lys Glu Leu Phe Lys Gly Phe Ala Arg His 
    930                 935                 940                 


Leu Ser His Leu Leu Thr Gln Lys Thr Ser Pro Gly Arg Ser Val Lys 
945                 950                 955                 960 


Glu Glu Ala Gln Asn Leu Ile Arg His Phe Phe His Gly Arg Ala Arg 
                965                 970                 975     


Cys Glu Ser Glu Ala Asp Trp His Gly Leu Cys Gly Pro Gln Arg 
            980                 985                 990     


<210>  9
<211>  380
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  9

Met Gly Ile Gln Gly Leu Ala Lys Leu Ile Ala Asp Val Ala Pro Ser 
1               5                   10                  15      


Ala Ile Arg Glu Asn Asp Ile Lys Ser Tyr Phe Gly Arg Lys Val Ala 
            20                  25                  30          


Ile Asp Ala Ser Met Ser Ile Tyr Gln Phe Leu Ile Ala Val Arg Gln 
        35                  40                  45              


Gly Gly Asp Val Leu Gln Asn Glu Glu Gly Glu Thr Thr Ser His Leu 
    50                  55                  60                  


Met Gly Met Phe Tyr Arg Thr Ile Arg Met Met Glu Asn Gly Ile Lys 
65                  70                  75                  80  


Pro Val Tyr Val Phe Asp Gly Lys Pro Pro Gln Leu Lys Ser Gly Glu 
                85                  90                  95      


Leu Ala Lys Arg Ser Glu Arg Arg Ala Glu Ala Glu Lys Gln Leu Gln 
            100                 105                 110         


Gln Ala Gln Ala Ala Gly Ala Glu Gln Glu Val Glu Lys Phe Thr Lys 
        115                 120                 125             


Arg Leu Val Lys Val Thr Lys Gln His Asn Asp Glu Cys Lys His Leu 
    130                 135                 140                 


Leu Ser Leu Met Gly Ile Pro Tyr Leu Asp Ala Pro Ser Glu Ala Glu 
145                 150                 155                 160 


Ala Ser Cys Ala Ala Leu Val Lys Ala Gly Lys Val Tyr Ala Ala Ala 
                165                 170                 175     


Thr Glu Asp Met Asp Cys Leu Thr Phe Gly Ser Pro Val Leu Met Arg 
            180                 185                 190         


His Leu Thr Ala Ser Glu Ala Lys Lys Leu Pro Ile Gln Glu Phe His 
        195                 200                 205             


Leu Ser Arg Ile Leu Gln Glu Leu Gly Leu Asn Gln Glu Gln Phe Val 
    210                 215                 220                 


Asp Leu Cys Ile Leu Leu Gly Ser Asp Tyr Cys Glu Ser Ile Arg Gly 
225                 230                 235                 240 


Ile Gly Pro Lys Arg Ala Val Asp Leu Ile Gln Lys His Lys Ser Ile 
                245                 250                 255     


Glu Glu Ile Val Arg Arg Leu Asp Pro Asn Lys Tyr Pro Val Pro Glu 
            260                 265                 270         


Asn Trp Leu His Lys Glu Ala His Gln Leu Phe Leu Glu Pro Glu Val 
        275                 280                 285             


Leu Asp Pro Glu Ser Val Glu Leu Lys Trp Ser Glu Pro Asn Glu Glu 
    290                 295                 300                 


Glu Leu Ile Lys Phe Met Cys Gly Glu Lys Gln Phe Ser Glu Glu Arg 
305                 310                 315                 320 


Ile Arg Ser Gly Val Lys Arg Leu Ser Lys Ser Arg Gln Gly Ser Thr 
                325                 330                 335     


Gln Gly Arg Leu Asp Asp Phe Phe Lys Val Thr Gly Ser Leu Ser Ser 
            340                 345                 350         


Ala Lys Arg Lys Glu Pro Glu Pro Lys Gly Ser Thr Lys Lys Lys Ala 
        355                 360                 365             


Lys Thr Gly Ala Ala Gly Lys Phe Lys Arg Gly Lys 
    370                 375                 380 


<210>  10
<211>  859
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  10

Met Thr Ser Lys Gln Ala Met Ser Ser Asn Glu Gln Glu Arg Leu Leu 
1               5                   10                  15      


Cys Tyr Asn Gly Glu Val Leu Val Phe Gln Leu Ser Lys Gly Asn Phe 
            20                  25                  30          


Ala Asp Lys Glu Pro Thr Lys Thr Pro Ile Leu His Val Arg Arg Met 
        35                  40                  45              


Val Phe Asp Arg Gly Thr Lys Val Phe Val Gln Lys Ser Thr Gly Phe 
    50                  55                  60                  


Phe Thr Ile Lys Glu Glu Asn Ser His Leu Lys Ile Met Cys Cys Asn 
65                  70                  75                  80  


Cys Val Ser Asp Phe Arg Thr Gly Ile Asn Leu Pro Tyr Ile Val Ile 
                85                  90                  95      


Glu Lys Asn Lys Lys Asn Asn Val Phe Glu Tyr Phe Leu Leu Ile Leu 
            100                 105                 110         


His Ser Thr Asn Lys Phe Glu Met Arg Leu Ser Phe Lys Leu Gly Tyr 
        115                 120                 125             


Glu Met Lys Asp Gly Leu Arg Val Leu Asn Gly Pro Leu Ile Leu Trp 
    130                 135                 140                 


Arg His Val Lys Ala Phe Phe Phe Ile Ser Ser Gln Thr Gly Lys Val 
145                 150                 155                 160 


Val Ser Val Ser Gly Asn Phe Ser Ser Ile Gln Trp Ala Gly Glu Ile 
                165                 170                 175     


Glu Asn Leu Gly Met Val Leu Leu Gly Leu Lys Glu Cys Cys Leu Ser 
            180                 185                 190         


Glu Glu Glu Cys Thr Gln Glu Pro Ser Lys Ser Asp Tyr Ala Ile Trp 
        195                 200                 205             


Asn Thr Lys Phe Cys Val Tyr Ser Leu Glu Ser Gln Glu Val Leu Ser 
    210                 215                 220                 


Asp Ile Tyr Ile Ile Pro Pro Ala Tyr Ser Ser Val Val Thr Tyr Val 
225                 230                 235                 240 


His Ile Cys Ala Thr Glu Ile Ile Lys Asn Gln Leu Arg Ile Ser Leu 
                245                 250                 255     


Ile Ala Leu Thr Arg Lys Asn Gln Leu Ile Ser Phe Gln Asn Gly Thr 
            260                 265                 270         


Pro Lys Asn Val Cys Gln Leu Pro Phe Gly Asp Pro Cys Ala Val Gln 
        275                 280                 285             


Leu Met Asp Ser Gly Gly Gly Asn Leu Phe Phe Val Val Ser Phe Ile 
    290                 295                 300                 


Ser Asn Asn Ala Cys Ala Val Trp Lys Glu Ser Phe Gln Val Ala Ala 
305                 310                 315                 320 


Lys Trp Glu Lys Leu Ser Leu Val Leu Ile Asp Asp Phe Ile Gly Ser 
                325                 330                 335     


Gly Thr Glu Gln Val Leu Leu Leu Phe Lys Asp Ser Leu Asn Ser Asp 
            340                 345                 350         


Cys Leu Thr Ser Phe Lys Ile Thr Asp Leu Gly Lys Ile Asn Tyr Ser 
        355                 360                 365             


Ser Glu Pro Ser Asp Cys Asn Glu Asp Asp Leu Phe Glu Asp Lys Gln 
    370                 375                 380                 


Glu Asn Arg Tyr Leu Val Val Pro Pro Leu Glu Thr Gly Leu Lys Val 
385                 390                 395                 400 


Cys Phe Ser Ser Phe Arg Glu Leu Arg Gln His Leu Leu Leu Lys Glu 
                405                 410                 415     


Lys Ile Ile Ser Lys Ser Tyr Lys Ala Leu Ile Asn Leu Val Gln Gly 
            420                 425                 430         


Lys Asp Asp Asn Thr Ser Ser Ala Glu Glu Lys Glu Cys Leu Val Pro 
        435                 440                 445             


Leu Cys Gly Glu Glu Glu Asn Ser Val His Ile Leu Asp Glu Lys Leu 
    450                 455                 460                 


Ser Asp Asn Phe Gln Asp Ser Glu Gln Leu Val Glu Lys Ile Trp Tyr 
465                 470                 475                 480 


Arg Val Ile Asp Asp Ser Leu Val Val Gly Val Lys Thr Thr Ser Ser 
                485                 490                 495     


Leu Lys Leu Ser Leu Asn Asp Val Thr Leu Ser Leu Leu Met Asp Gln 
            500                 505                 510         


Ala His Asp Ser Arg Phe Arg Leu Leu Lys Cys Gln Asn Arg Val Ile 
        515                 520                 525             


Lys Leu Ser Thr Asn Pro Phe Pro Ala Pro Tyr Leu Met Pro Cys Glu 
    530                 535                 540                 


Ile Gly Leu Glu Ala Lys Arg Val Thr Leu Thr Pro Asp Ser Lys Lys 
545                 550                 555                 560 


Glu Glu Ser Phe Val Cys Glu His Pro Ser Lys Lys Glu Cys Val Gln 
                565                 570                 575     


Ile Ile Thr Ala Val Thr Ser Leu Ser Pro Leu Leu Thr Phe Ser Lys 
            580                 585                 590         


Phe Cys Cys Thr Val Leu Leu Gln Ile Met Glu Arg Glu Ser Gly Asn 
        595                 600                 605             


Cys Pro Lys Asp Arg Tyr Val Val Cys Gly Arg Val Phe Leu Ser Leu 
    610                 615                 620                 


Glu Asp Leu Ser Thr Gly Lys Tyr Leu Leu Thr Phe Pro Lys Lys Lys 
625                 630                 635                 640 


Pro Ile Glu His Met Glu Asp Leu Phe Ala Leu Leu Ala Ala Phe His 
                645                 650                 655     


Lys Ser Cys Phe Gln Ile Thr Ser Pro Gly Tyr Ala Leu Asn Ser Met 
            660                 665                 670         


Lys Val Trp Leu Leu Glu His Met Lys Cys Glu Ile Ile Lys Glu Phe 
        675                 680                 685             


Pro Glu Val Tyr Phe Cys Glu Arg Pro Gly Ser Phe Tyr Gly Thr Leu 
    690                 695                 700                 


Phe Thr Trp Lys Gln Arg Thr Pro Phe Glu Gly Ile Leu Ile Ile Tyr 
705                 710                 715                 720 


Ser Arg Asn Gln Thr Val Met Phe Gln Cys Leu His Asn Leu Ile Arg 
                725                 730                 735     


Ile Leu Pro Ile Asn Cys Phe Leu Lys Asn Leu Lys Ser Gly Ser Glu 
            740                 745                 750         


Asn Phe Leu Ile Asp Asn Met Ala Phe Thr Leu Glu Lys Glu Leu Val 
        755                 760                 765             


Thr Leu Ser Ser Leu Ser Ser Ala Ile Ala Lys His Glu Ser Asn Phe 
    770                 775                 780                 


Met Gln Arg Cys Glu Val Ser Lys Gly Lys Ser Ser Val Val Ala Ala 
785                 790                 795                 800 


Ala Leu Ser Asp Arg Arg Glu Asn Ile His Pro Tyr Arg Lys Glu Leu 
                805                 810                 815     


Gln Arg Glu Lys Lys Lys Met Leu Gln Thr Asn Leu Lys Val Ser Gly 
            820                 825                 830         


Ala Leu Tyr Arg Glu Ile Thr Leu Lys Val Ala Glu Val Gln Leu Lys 
        835                 840                 845             


Ser Asp Phe Ala Ala Gln Lys Leu Ser Asn Leu 
    850                 855                 


<210>  11
<211>  374
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  11

Met Glu Ser Leu Leu Gln His Leu Asp Arg Phe Ser Glu Leu Leu Ala 
1               5                   10                  15      


Val Ser Ser Thr Thr Tyr Val Ser Thr Trp Asp Pro Ala Thr Val Arg 
            20                  25                  30          


Arg Ala Leu Gln Trp Ala Arg Tyr Leu Arg His Ile His Arg Arg Phe 
        35                  40                  45              


Gly Arg His Gly Pro Ile Arg Thr Ala Leu Glu Arg Arg Leu His Asn 
    50                  55                  60                  


Gln Trp Arg Gln Glu Gly Gly Phe Gly Arg Gly Pro Val Pro Gly Leu 
65                  70                  75                  80  


Ala Asn Phe Gln Ala Leu Gly His Cys Asp Val Leu Leu Ser Leu Arg 
                85                  90                  95      


Leu Leu Glu Asn Arg Ala Leu Gly Asp Ala Ala Arg Tyr His Leu Val 
            100                 105                 110         


Gln Gln Leu Phe Pro Gly Pro Gly Val Arg Asp Ala Asp Glu Glu Thr 
        115                 120                 125             


Leu Gln Glu Ser Leu Ala Arg Leu Ala Arg Arg Arg Ser Ala Val His 
    130                 135                 140                 


Met Leu Arg Phe Asn Gly Tyr Arg Glu Asn Pro Asn Leu Gln Glu Asp 
145                 150                 155                 160 


Ser Leu Met Lys Thr Gln Ala Glu Leu Leu Leu Glu Arg Leu Gln Glu 
                165                 170                 175     


Val Gly Lys Ala Glu Ala Glu Arg Pro Ala Arg Phe Leu Ser Ser Leu 
            180                 185                 190         


Trp Glu Arg Leu Pro Gln Asn Asn Phe Leu Lys Val Ile Ala Val Ala 
        195                 200                 205             


Leu Leu Gln Pro Pro Leu Ser Arg Arg Pro Gln Glu Glu Leu Glu Pro 
    210                 215                 220                 


Gly Ile His Lys Ser Pro Gly Glu Gly Ser Gln Val Leu Val His Trp 
225                 230                 235                 240 


Leu Leu Gly Asn Ser Glu Val Phe Ala Ala Phe Cys Arg Ala Leu Pro 
                245                 250                 255     


Ala Gly Leu Leu Thr Leu Val Thr Ser Arg His Pro Ala Leu Ser Pro 
            260                 265                 270         


Val Tyr Leu Gly Leu Leu Thr Asp Trp Gly Gln Arg Leu His Tyr Asp 
        275                 280                 285             


Leu Gln Lys Gly Ile Trp Val Gly Thr Glu Ser Gln Asp Val Pro Trp 
    290                 295                 300                 


Glu Glu Leu His Asn Arg Phe Gln Ser Leu Cys Gln Ala Pro Pro Pro 
305                 310                 315                 320 


Leu Lys Asp Lys Val Leu Thr Ala Leu Glu Thr Cys Lys Ala Gln Asp 
                325                 330                 335     


Gly Asp Phe Glu Val Pro Gly Leu Ser Ile Trp Thr Asp Leu Leu Leu 
            340                 345                 350         


Ala Leu Arg Ser Gly Ala Phe Arg Lys Arg Gln Val Leu Gly Leu Ser 
        355                 360                 365             


Ala Gly Leu Ser Ser Val 
    370                 


<210>  12
<211>  622
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  12

Met Ser Arg Gln Thr Thr Ser Val Gly Ser Ser Cys Leu Asp Leu Trp 
1               5                   10                  15      


Arg Glu Lys Asn Asp Arg Leu Val Arg Gln Ala Lys Val Ala Gln Asn 
            20                  25                  30          


Ser Gly Leu Thr Leu Arg Arg Gln Gln Leu Ala Gln Asp Ala Leu Glu 
        35                  40                  45              


Gly Leu Arg Gly Leu Leu His Ser Leu Gln Gly Leu Pro Ala Ala Val 
    50                  55                  60                  


Pro Val Leu Pro Leu Glu Leu Thr Val Thr Cys Asn Phe Ile Ile Leu 
65                  70                  75                  80  


Arg Ala Ser Leu Ala Gln Gly Phe Thr Glu Asp Gln Ala Gln Asp Ile 
                85                  90                  95      


Gln Arg Ser Leu Glu Arg Val Leu Glu Thr Gln Glu Gln Gln Gly Pro 
            100                 105                 110         


Arg Leu Glu Gln Gly Leu Arg Glu Leu Trp Asp Ser Val Leu Arg Ala 
        115                 120                 125             


Ser Cys Leu Leu Pro Glu Leu Leu Ser Ala Leu His Arg Leu Val Gly 
    130                 135                 140                 


Leu Gln Ala Ala Leu Trp Leu Ser Ala Asp Arg Leu Gly Asp Leu Ala 
145                 150                 155                 160 


Leu Leu Leu Glu Thr Leu Asn Gly Ser Gln Ser Gly Ala Ser Lys Asp 
                165                 170                 175     


Leu Leu Leu Leu Leu Lys Thr Trp Ser Pro Pro Ala Glu Glu Leu Asp 
            180                 185                 190         


Ala Pro Leu Thr Leu Gln Asp Ala Gln Gly Leu Lys Asp Val Leu Leu 
        195                 200                 205             


Thr Ala Phe Ala Tyr Arg Gln Gly Leu Gln Glu Leu Ile Thr Gly Asn 
    210                 215                 220                 


Pro Asp Lys Ala Leu Ser Ser Leu His Glu Ala Ala Ser Gly Leu Cys 
225                 230                 235                 240 


Pro Arg Pro Val Leu Val Gln Val Tyr Thr Ala Leu Gly Ser Cys His 
                245                 250                 255     


Arg Lys Met Gly Asn Pro Gln Arg Ala Leu Leu Tyr Leu Val Ala Ala 
            260                 265                 270         


Leu Lys Glu Gly Ser Ala Trp Gly Pro Pro Leu Leu Glu Ala Ser Arg 
        275                 280                 285             


Leu Tyr Gln Gln Leu Gly Asp Thr Thr Ala Glu Leu Glu Ser Leu Glu 
    290                 295                 300                 


Leu Leu Val Glu Ala Leu Asn Val Pro Cys Ser Ser Lys Ala Pro Gln 
305                 310                 315                 320 


Phe Leu Ile Glu Val Glu Leu Leu Leu Pro Pro Pro Asp Leu Ala Ser 
                325                 330                 335     


Pro Leu His Cys Gly Thr Gln Ser Gln Thr Lys His Ile Leu Ala Ser 
            340                 345                 350         


Arg Cys Leu Gln Thr Gly Arg Ala Gly Asp Ala Ala Glu His Tyr Leu 
        355                 360                 365             


Asp Leu Leu Ala Leu Leu Leu Asp Ser Ser Glu Pro Arg Phe Ser Pro 
    370                 375                 380                 


Pro Pro Ser Pro Pro Gly Pro Cys Met Pro Glu Val Phe Leu Glu Ala 
385                 390                 395                 400 


Ala Val Ala Leu Ile Gln Ala Gly Arg Ala Gln Asp Ala Leu Thr Leu 
                405                 410                 415     


Cys Glu Glu Leu Leu Ser Arg Thr Ser Ser Leu Leu Pro Lys Met Ser 
            420                 425                 430         


Arg Leu Trp Glu Asp Ala Arg Lys Gly Thr Lys Glu Leu Pro Tyr Cys 
        435                 440                 445             


Pro Leu Trp Val Ser Ala Thr His Leu Leu Gln Gly Gln Ala Trp Val 
    450                 455                 460                 


Gln Leu Gly Ala Gln Lys Val Ala Ile Ser Glu Phe Ser Arg Cys Leu 
465                 470                 475                 480 


Glu Leu Leu Phe Arg Ala Thr Pro Glu Glu Lys Glu Gln Gly Ala Ala 
                485                 490                 495     


Phe Asn Cys Glu Gln Gly Cys Lys Ser Asp Ala Ala Leu Gln Gln Leu 
            500                 505                 510         


Arg Ala Ala Ala Leu Ile Ser Arg Gly Leu Glu Trp Val Ala Ser Gly 
        515                 520                 525             


Gln Asp Thr Lys Ala Leu Gln Asp Phe Leu Leu Ser Val Gln Met Cys 
    530                 535                 540                 


Pro Gly Asn Arg Asp Thr Tyr Phe His Leu Leu Gln Thr Leu Lys Arg 
545                 550                 555                 560 


Leu Asp Arg Arg Asp Glu Ala Thr Ala Leu Trp Trp Arg Leu Glu Ala 
                565                 570                 575     


Gln Thr Lys Gly Ser His Glu Asp Ala Leu Trp Ser Leu Pro Leu Tyr 
            580                 585                 590         


Leu Glu Ser Tyr Leu Ser Trp Ile Arg Pro Ser Asp Arg Asp Ala Phe 
        595                 600                 605             


Leu Glu Glu Phe Arg Thr Ser Leu Pro Lys Ser Cys Asp Leu 
    610                 615                 620         


<210>  13
<211>  2048
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  13

Met Ser Gly Arg Gln Arg Thr Leu Phe Gln Thr Trp Gly Ser Ser Ile 
1               5                   10                  15      


Ser Arg Ser Ser Gly Thr Pro Gly Cys Ser Ser Gly Thr Glu Arg Pro 
            20                  25                  30          


Gln Ser Pro Gly Ser Ser Lys Ala Pro Leu Pro Ala Ala Ala Glu Ala 
        35                  40                  45              


Gln Leu Glu Ser Asp Asp Asp Val Leu Leu Val Ala Ala Tyr Glu Ala 
    50                  55                  60                  


Glu Arg Gln Leu Cys Leu Glu Asn Gly Gly Phe Cys Thr Ser Ala Gly 
65                  70                  75                  80  


Ala Leu Trp Ile Tyr Pro Thr Asn Cys Pro Val Arg Asp Tyr Gln Leu 
                85                  90                  95      


His Ile Ser Arg Ala Ala Leu Phe Cys Asn Thr Leu Val Cys Leu Pro 
            100                 105                 110         


Thr Gly Leu Gly Lys Thr Phe Ile Ala Ala Val Val Met Tyr Asn Phe 
        115                 120                 125             


Tyr Arg Trp Phe Pro Ser Gly Lys Val Val Phe Met Ala Pro Thr Lys 
    130                 135                 140                 


Pro Leu Val Thr Gln Gln Ile Glu Ala Cys Tyr Gln Val Met Gly Ile 
145                 150                 155                 160 


Pro Gln Ser His Met Ala Glu Met Thr Gly Ser Thr Gln Ala Ser Thr 
                165                 170                 175     


Arg Lys Glu Ile Trp Cys Ser Lys Arg Val Leu Phe Leu Thr Pro Gln 
            180                 185                 190         


Val Met Val Asn Asp Leu Ser Arg Gly Ala Cys Pro Ala Ala Glu Ile 
        195                 200                 205             


Lys Cys Leu Val Ile Asp Glu Ala His Lys Ala Leu Gly Asn Tyr Ala 
    210                 215                 220                 


Tyr Cys Gln Val Val Arg Glu Leu Val Lys Tyr Thr Asn His Phe Arg 
225                 230                 235                 240 


Ile Leu Ala Leu Ser Ala Thr Pro Gly Ser Asp Ile Lys Ala Val Gln 
                245                 250                 255     


Gln Val Ile Thr Asn Leu Leu Ile Gly Gln Ile Glu Leu Arg Ser Glu 
            260                 265                 270         


Asp Ser Pro Asp Ile Leu Thr Tyr Ser His Glu Arg Lys Val Glu Lys 
        275                 280                 285             


Leu Ile Val Pro Leu Gly Glu Glu Leu Ala Ala Ile Gln Lys Thr Tyr 
    290                 295                 300                 


Ile Gln Ile Leu Glu Ser Phe Ala Arg Ser Leu Ile Gln Arg Asn Val 
305                 310                 315                 320 


Leu Met Arg Arg Asp Ile Pro Asn Leu Thr Lys Tyr Gln Ile Ile Leu 
                325                 330                 335     


Ala Arg Asp Gln Phe Arg Lys Asn Pro Ser Pro Asn Ile Val Gly Ile 
            340                 345                 350         


Gln Gln Gly Ile Ile Glu Gly Glu Phe Ala Ile Cys Ile Ser Leu Tyr 
        355                 360                 365             


His Gly Tyr Glu Leu Leu Gln Gln Met Gly Met Arg Ser Leu Tyr Phe 
    370                 375                 380                 


Phe Leu Cys Gly Ile Met Asp Gly Thr Lys Gly Met Thr Arg Ser Lys 
385                 390                 395                 400 


Asn Glu Leu Gly Arg Asn Glu Asp Phe Met Lys Leu Tyr Asn His Leu 
                405                 410                 415     


Glu Cys Met Phe Ala Arg Thr Arg Ser Thr Ser Ala Asn Gly Ile Ser 
            420                 425                 430         


Ala Ile Gln Gln Gly Asp Lys Asn Lys Lys Phe Val Tyr Ser His Pro 
        435                 440                 445             


Lys Leu Lys Lys Leu Glu Glu Val Val Ile Glu His Phe Lys Ser Trp 
    450                 455                 460                 


Asn Ala Glu Asn Thr Thr Glu Lys Lys Arg Asp Glu Thr Arg Val Met 
465                 470                 475                 480 


Ile Phe Ser Ser Phe Arg Asp Ser Val Gln Glu Ile Ala Glu Met Leu 
                485                 490                 495     


Ser Gln His Gln Pro Ile Ile Arg Val Met Thr Phe Val Gly His Ala 
            500                 505                 510         


Ser Gly Lys Ser Thr Lys Gly Phe Thr Gln Lys Glu Gln Leu Glu Val 
        515                 520                 525             


Val Lys Gln Phe Arg Asp Gly Gly Tyr Asn Thr Leu Val Ser Thr Cys 
    530                 535                 540                 


Val Gly Glu Glu Gly Leu Asp Ile Gly Glu Val Asp Leu Ile Ile Cys 
545                 550                 555                 560 


Phe Asp Ser Gln Lys Ser Pro Ile Arg Leu Val Gln Arg Met Gly Arg 
                565                 570                 575     


Thr Gly Arg Lys Arg Gln Gly Arg Ile Val Ile Ile Leu Ser Glu Gly 
            580                 585                 590         


Arg Glu Glu Arg Ile Tyr Asn Gln Ser Gln Ser Asn Lys Arg Ser Ile 
        595                 600                 605             


Tyr Lys Ala Ile Ser Ser Asn Arg Gln Val Leu His Phe Tyr Gln Arg 
    610                 615                 620                 


Ser Pro Arg Met Val Pro Asp Gly Ile Asn Pro Lys Leu His Lys Met 
625                 630                 635                 640 


Phe Ile Thr His Gly Val Tyr Glu Pro Glu Lys Pro Ser Arg Asn Leu 
                645                 650                 655     


Gln Arg Lys Ser Ser Ile Phe Ser Tyr Arg Asp Gly Met Arg Gln Ser 
            660                 665                 670         


Ser Leu Lys Lys Asp Trp Phe Leu Ser Glu Glu Glu Phe Lys Leu Trp 
        675                 680                 685             


Asn Arg Leu Tyr Arg Leu Arg Asp Ser Asp Glu Ile Lys Glu Ile Thr 
    690                 695                 700                 


Leu Pro Gln Val Gln Phe Ser Ser Leu Gln Asn Glu Glu Asn Lys Pro 
705                 710                 715                 720 


Ala Gln Glu Ser Thr Thr Gly Ile His Gln Leu Ser Leu Ser Glu Trp 
                725                 730                 735     


Arg Leu Trp Gln Asp His Pro Leu Pro Thr His Gln Val Asp His Ser 
            740                 745                 750         


Asp Arg Cys Arg His Phe Ile Gly Leu Met Gln Met Ile Glu Gly Met 
        755                 760                 765             


Arg His Glu Glu Gly Glu Cys Ser Tyr Glu Leu Glu Val Glu Ser Tyr 
    770                 775                 780                 


Leu Gln Met Glu Asp Val Thr Ser Thr Phe Ile Ala Pro Arg Asn Glu 
785                 790                 795                 800 


Ser Asn Asn Leu Ala Ser Asp Thr Phe Ile Thr His Lys Lys Ser Ser 
                805                 810                 815     


Phe Ile Lys Asn Ile Asn Gln Gly Ser Ser Ser Ser Val Ile Glu Ser 
            820                 825                 830         


Asp Glu Glu Cys Ala Glu Ile Val Lys Gln Thr His Ile Lys Pro Thr 
        835                 840                 845             


Lys Ile Val Ser Leu Lys Lys Lys Val Ser Lys Glu Ile Lys Lys Asp 
    850                 855                 860                 


Gln Leu Lys Lys Glu Asn Asn His Gly Ile Ile Asp Ser Val Asp Asn 
865                 870                 875                 880 


Asp Arg Asn Ser Thr Val Glu Asn Ile Phe Gln Glu Asp Leu Pro Asn 
                885                 890                 895     


Asp Lys Arg Thr Ser Asp Thr Asp Glu Ile Ala Ala Thr Cys Thr Ile 
            900                 905                 910         


Asn Glu Asn Val Ile Lys Glu Pro Cys Val Leu Leu Thr Glu Cys Gln 
        915                 920                 925             


Phe Thr Asn Lys Ser Thr Ser Ser Leu Ala Gly Asn Val Leu Asp Ser 
    930                 935                 940                 


Gly Tyr Asn Ser Phe Asn Asp Glu Lys Ser Val Ser Ser Asn Leu Phe 
945                 950                 955                 960 


Leu Pro Phe Glu Glu Glu Leu Tyr Ile Val Arg Thr Asp Asp Gln Phe 
                965                 970                 975     


Tyr Asn Cys His Ser Leu Thr Lys Glu Val Leu Ala Asn Val Glu Arg 
            980                 985                 990         


Phe Leu Ser Tyr Ser Pro Pro Pro  Leu Ser Gly Leu Ser  Asp Leu Glu 
        995                 1000                 1005             


Tyr Glu  Ile Ala Lys Gly Thr  Ala Leu Glu Asn Leu  Leu Phe Leu 
    1010                 1015                 1020             


Pro Cys  Ala Glu His Leu Arg  Ser Asp Lys Cys Thr  Cys Leu Leu 
    1025                 1030                 1035             


Ser His  Ser Ala Val Asn Ser  Gln Gln Asn Leu Glu  Leu Asn Ser 
    1040                 1045                 1050             


Leu Lys  Cys Ile Asn Tyr Pro  Ser Glu Lys Ser Cys  Leu Tyr Asp 
    1055                 1060                 1065             


Ile Pro  Asn Asp Asn Ile Ser  Asp Glu Pro Ser Leu  Cys Asp Cys 
    1070                 1075                 1080             


Asp Val  His Lys His Asn Gln  Asn Glu Asn Leu Val  Pro Asn Asn 
    1085                 1090                 1095             


Arg Val  Gln Ile His Arg Ser  Pro Ala Gln Asn Leu  Val Gly Glu 
    1100                 1105                 1110             


Asn Asn  His Asp Val Asp Asn  Ser Asp Leu Pro Val  Leu Ser Thr 
    1115                 1120                 1125             


Asp Gln  Asp Glu Ser Leu Leu  Leu Phe Glu Asp Val  Asn Thr Glu 
    1130                 1135                 1140             


Phe Asp  Asp Val Ser Leu Ser  Pro Leu Asn Ser Lys  Ser Glu Ser 
    1145                 1150                 1155             


Leu Pro  Val Ser Asp Lys Thr  Ala Ile Ser Glu Thr  Pro Leu Val 
    1160                 1165                 1170             


Ser Gln  Phe Leu Ile Ser Asp  Glu Leu Leu Leu Asp  Asn Asn Ser 
    1175                 1180                 1185             


Glu Leu  Gln Asp Gln Ile Thr  Arg Asp Ala Asn Ser  Phe Lys Ser 
    1190                 1195                 1200             


Arg Asp  Gln Arg Gly Val Gln  Glu Glu Lys Val Lys  Asn His Glu 
    1205                 1210                 1215             


Asp Ile  Phe Asp Cys Ser Arg  Asp Leu Phe Ser Val  Thr Phe Asp 
    1220                 1225                 1230             


Leu Gly  Phe Cys Ser Pro Asp  Ser Asp Asp Glu Ile  Leu Glu His 
    1235                 1240                 1245             


Thr Ser  Asp Ser Asn Arg Pro  Leu Asp Asp Leu Tyr  Gly Arg Tyr 
    1250                 1255                 1260             


Leu Glu  Ile Lys Glu Ile Ser  Asp Ala Asn Tyr Val  Ser Asn Gln 
    1265                 1270                 1275             


Ala Leu  Ile Pro Arg Asp His  Ser Lys Asn Phe Thr  Ser Gly Thr 
    1280                 1285                 1290             


Val Ile  Ile Pro Ser Asn Glu  Asp Met Gln Asn Pro  Asn Tyr Val 
    1295                 1300                 1305             


His Leu  Pro Leu Ser Ala Ala  Lys Asn Glu Glu Leu  Leu Ser Pro 
    1310                 1315                 1320             


Gly Tyr  Ser Gln Phe Ser Leu  Pro Val Gln Lys Lys  Val Met Ser 
    1325                 1330                 1335             


Thr Pro  Leu Ser Lys Ser Asn  Thr Leu Asn Ser Phe  Ser Lys Ile 
    1340                 1345                 1350             


Arg Lys  Glu Ile Leu Lys Thr  Pro Asp Ser Ser Lys  Glu Lys Val 
    1355                 1360                 1365             


Asn Leu  Gln Arg Phe Lys Glu  Ala Leu Asn Ser Thr  Phe Asp Tyr 
    1370                 1375                 1380             


Ser Glu  Phe Ser Leu Glu Lys  Ser Lys Ser Ser Gly  Pro Met Tyr 
    1385                 1390                 1395             


Leu His  Lys Ser Cys His Ser  Val Glu Asp Gly Gln  Leu Leu Thr 
    1400                 1405                 1410             


Ser Asn  Glu Ser Glu Asp Asp  Glu Ile Phe Arg Arg  Lys Val Lys 
    1415                 1420                 1425             


Arg Ala  Lys Gly Asn Val Leu  Asn Ser Pro Glu Asp  Gln Lys Asn 
    1430                 1435                 1440             


Ser Glu  Val Asp Ser Pro Leu  His Ala Val Lys Lys  Arg Arg Phe 
    1445                 1450                 1455             


Pro Ile  Asn Arg Ser Glu Leu  Ser Ser Ser Asp Glu  Ser Glu Asn 
    1460                 1465                 1470             


Phe Pro  Lys Pro Cys Ser Gln  Leu Glu Asp Phe Lys  Val Cys Asn 
    1475                 1480                 1485             


Gly Asn  Ala Arg Arg Gly Ile  Lys Val Pro Lys Arg  Gln Ser His 
    1490                 1495                 1500             


Leu Lys  His Val Ala Arg Lys  Phe Leu Asp Asp Glu  Ala Glu Leu 
    1505                 1510                 1515             


Ser Glu  Glu Asp Ala Glu Tyr  Val Ser Ser Asp Glu  Asn Asp Glu 
    1520                 1525                 1530             


Ser Glu  Asn Glu Gln Asp Ser  Ser Leu Leu Asp Phe  Leu Asn Asp 
    1535                 1540                 1545             


Glu Thr  Gln Leu Ser Gln Ala  Ile Asn Asp Ser Glu  Met Arg Ala 
    1550                 1555                 1560             


Ile Tyr  Met Lys Ser Leu Arg  Ser Pro Met Met Asn  Asn Lys Tyr 
    1565                 1570                 1575             


Lys Met  Ile His Lys Thr His  Lys Asn Ile Asn Ile  Phe Ser Gln 
    1580                 1585                 1590             


Ile Pro  Glu Gln Asp Glu Thr  Tyr Leu Glu Asp Ser  Phe Cys Val 
    1595                 1600                 1605             


Asp Glu  Glu Glu Ser Cys Lys  Gly Gln Ser Ser Glu  Glu Glu Val 
    1610                 1615                 1620             


Cys Val  Asp Phe Asn Leu Ile  Thr Asp Asp Cys Phe  Ala Asn Ser 
    1625                 1630                 1635             


Lys Lys  Tyr Lys Thr Arg Arg  Ala Val Met Leu Lys  Glu Met Met 
    1640                 1645                 1650             


Glu Gln  Asn Cys Ala His Ser  Lys Lys Lys Leu Ser  Arg Ile Ile 
    1655                 1660                 1665             


Leu Pro  Asp Asp Ser Ser Glu  Glu Glu Asn Asn Val  Asn Asp Lys 
    1670                 1675                 1680             


Arg Glu  Ser Asn Ile Ala Val  Asn Pro Ser Thr Val  Lys Lys Asn 
    1685                 1690                 1695             


Lys Gln  Gln Asp His Cys Leu  Asn Ser Val Pro Ser  Gly Ser Ser 
    1700                 1705                 1710             


Ala Gln  Ser Lys Val Arg Ser  Thr Pro Arg Val Asn  Pro Leu Ala 
    1715                 1720                 1725             


Lys Gln  Ser Lys Gln Thr Ser  Leu Asn Leu Lys Asp  Thr Ile Ser 
    1730                 1735                 1740             


Glu Val  Ser Asp Phe Lys Pro  Gln Asn His Asn Glu  Val Gln Ser 
    1745                 1750                 1755             


Thr Thr  Pro Pro Phe Thr Thr  Val Asp Ser Gln Lys  Asp Cys Arg 
    1760                 1765                 1770             


Lys Phe  Pro Val Pro Gln Lys  Asp Gly Ser Ala Leu  Glu Asp Ser 
    1775                 1780                 1785             


Ser Thr  Ser Gly Ala Ser Cys  Ser Lys Ser Arg Pro  His Leu Ala 
    1790                 1795                 1800             


Gly Thr  His Thr Ser Leu Arg  Leu Pro Gln Glu Gly  Lys Gly Thr 
    1805                 1810                 1815             


Cys Ile  Leu Val Gly Gly His  Glu Ile Thr Ser Gly  Leu Glu Val 
    1820                 1825                 1830             


Ile Ser  Ser Leu Arg Ala Ile  His Gly Leu Gln Val  Glu Val Cys 
    1835                 1840                 1845             


Pro Leu  Asn Gly Cys Asp Tyr  Ile Val Ser Asn Arg  Met Val Val 
    1850                 1855                 1860             


Glu Arg  Arg Ser Gln Ser Glu  Met Leu Asn Ser Val  Asn Lys Asn 
    1865                 1870                 1875             


Lys Phe  Ile Glu Gln Ile Gln  His Leu Gln Ser Met  Phe Glu Arg 
    1880                 1885                 1890             


Ile Cys  Val Ile Val Glu Lys  Asp Arg Glu Lys Thr  Gly Asp Thr 
    1895                 1900                 1905             


Ser Arg  Met Phe Arg Arg Thr  Lys Ser Tyr Asp Ser  Leu Leu Thr 
    1910                 1915                 1920             


Thr Leu  Ile Gly Ala Gly Ile  Arg Ile Leu Phe Ser  Ser Cys Gln 
    1925                 1930                 1935             


Glu Glu  Thr Ala Asp Leu Leu  Lys Glu Leu Ser Leu  Val Glu Gln 
    1940                 1945                 1950             


Arg Lys  Asn Val Gly Ile His  Val Pro Thr Val Val  Asn Ser Asn 
    1955                 1960                 1965             


Lys Ser  Glu Ala Leu Gln Phe  Tyr Leu Ser Ile Pro  Asn Ile Ser 
    1970                 1975                 1980             


Tyr Ile  Thr Ala Leu Asn Met  Cys His Gln Phe Ser  Ser Val Lys 
    1985                 1990                 1995             


Arg Met  Ala Asn Ser Ser Leu  Gln Glu Ile Ser Met  Tyr Ala Gln 
    2000                 2005                 2010             


Val Thr  His Gln Lys Ala Glu  Glu Ile Tyr Arg Tyr  Ile His Tyr 
    2015                 2020                 2025             


Val Phe  Asp Ile Gln Met Leu  Pro Asn Asp Leu Asn  Gln Asp Arg 
    2030                 2035                 2040             


Leu Lys  Ser Asp Ile 
    2045             


<210>  14
<211>  1186
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  14

Met Asp Glu Pro Pro Gly Lys Pro Leu Ser Cys Glu Glu Lys Glu Lys 
1               5                   10                  15      


Leu Lys Glu Lys Leu Ala Phe Leu Lys Arg Glu Tyr Ser Lys Thr Leu 
            20                  25                  30          


Ala Arg Leu Gln Arg Ala Gln Arg Ala Glu Lys Ile Lys His Ser Ile 
        35                  40                  45              


Lys Lys Thr Val Glu Glu Gln Asp Cys Leu Ser Gln Gln Asp Leu Ser 
    50                  55                  60                  


Pro Gln Leu Lys His Ser Glu Pro Lys Asn Lys Ile Cys Val Tyr Asp 
65                  70                  75                  80  


Lys Leu His Ile Lys Thr His Leu Asp Glu Glu Thr Gly Glu Lys Thr 
                85                  90                  95      


Ser Ile Thr Leu Asp Val Gly Pro Glu Ser Phe Asn Pro Gly Asp Gly 
            100                 105                 110         


Pro Gly Gly Leu Pro Ile Gln Arg Thr Asp Asp Thr Gln Glu His Phe 
        115                 120                 125             


Pro His Arg Val Ser Asp Pro Ser Gly Glu Gln Lys Gln Lys Leu Pro 
    130                 135                 140                 


Ser Arg Arg Lys Lys Gln Gln Lys Arg Thr Phe Ile Ser Gln Glu Arg 
145                 150                 155                 160 


Asp Cys Val Phe Gly Thr Asp Ser Leu Arg Leu Ser Gly Lys Arg Leu 
                165                 170                 175     


Lys Glu Gln Glu Glu Ile Ser Ser Lys Asn Pro Ala Arg Ser Pro Val 
            180                 185                 190         


Thr Glu Ile Arg Thr His Leu Leu Ser Leu Lys Ser Glu Leu Pro Asp 
        195                 200                 205             


Ser Pro Glu Pro Val Thr Glu Ile Asn Glu Asp Ser Val Leu Ile Pro 
    210                 215                 220                 


Pro Thr Ala Gln Pro Glu Lys Gly Val Asp Thr Phe Leu Arg Arg Pro 
225                 230                 235                 240 


Asn Phe Thr Arg Ala Thr Thr Val Pro Leu Gln Thr Leu Ser Asp Ser 
                245                 250                 255     


Gly Ser Ser Gln His Leu Glu His Ile Pro Pro Lys Gly Ser Ser Glu 
            260                 265                 270         


Leu Thr Thr His Asp Leu Lys Asn Ile Arg Phe Thr Ser Pro Val Ser 
        275                 280                 285             


Leu Glu Ala Gln Gly Lys Lys Met Thr Val Ser Thr Asp Asn Leu Leu 
    290                 295                 300                 


Val Asn Lys Ala Ile Ser Lys Ser Gly Gln Leu Pro Thr Ser Ser Asn 
305                 310                 315                 320 


Leu Glu Ala Asn Ile Ser Cys Ser Leu Asn Glu Leu Thr Tyr Asn Asn 
                325                 330                 335     


Leu Pro Ala Asn Glu Asn Gln Asn Leu Lys Glu Gln Asn Gln Thr Glu 
            340                 345                 350         


Lys Ser Leu Lys Ser Pro Ser Asp Thr Leu Asp Gly Arg Asn Glu Asn 
        355                 360                 365             


Leu Gln Glu Ser Glu Ile Leu Ser Gln Pro Lys Ser Leu Ser Leu Glu 
    370                 375                 380                 


Ala Thr Ser Pro Leu Ser Ala Glu Lys His Ser Cys Thr Val Pro Glu 
385                 390                 395                 400 


Gly Leu Leu Phe Pro Ala Glu Tyr Tyr Val Arg Thr Thr Arg Ser Met 
                405                 410                 415     


Ser Asn Cys Gln Arg Lys Val Ala Val Glu Ala Val Ile Gln Ser His 
            420                 425                 430         


Leu Asp Val Lys Lys Lys Gly Phe Lys Asn Lys Asn Lys Asp Ala Ser 
        435                 440                 445             


Lys Asn Leu Asn Leu Ser Asn Glu Glu Thr Asp Gln Ser Glu Ile Arg 
    450                 455                 460                 


Met Ser Gly Thr Cys Thr Gly Gln Pro Ser Ser Arg Thr Ser Gln Lys 
465                 470                 475                 480 


Leu Leu Ser Leu Thr Lys Val Ser Ser Pro Ala Gly Pro Thr Glu Asp 
                485                 490                 495     


Asn Asp Leu Ser Arg Lys Ala Val Ala Gln Ala Pro Gly Arg Arg Tyr 
            500                 505                 510         


Thr Gly Lys Arg Lys Ser Ala Cys Thr Pro Ala Ser Asp His Cys Glu 
        515                 520                 525             


Pro Leu Leu Pro Thr Ser Ser Leu Ser Ile Val Asn Arg Ser Lys Glu 
    530                 535                 540                 


Glu Val Thr Ser His Lys Tyr Gln His Glu Lys Leu Phe Ile Gln Val 
545                 550                 555                 560 


Lys Gly Lys Lys Ser Arg His Gln Lys Glu Asp Ser Leu Ser Trp Ser 
                565                 570                 575     


Asn Ser Ala Tyr Leu Ser Leu Asp Asp Asp Ala Phe Thr Ala Pro Phe 
            580                 585                 590         


His Arg Asp Gly Met Leu Ser Leu Lys Gln Leu Leu Ser Phe Leu Ser 
        595                 600                 605             


Ile Thr Asp Phe Gln Leu Pro Asp Glu Asp Phe Gly Pro Leu Lys Leu 
    610                 615                 620                 


Glu Lys Val Lys Ser Cys Ser Glu Lys Pro Val Glu Pro Phe Glu Ser 
625                 630                 635                 640 


Lys Met Phe Gly Glu Arg His Leu Lys Glu Gly Ser Cys Ile Phe Pro 
                645                 650                 655     


Glu Glu Leu Ser Pro Lys Arg Met Asp Thr Glu Met Glu Asp Leu Glu 
            660                 665                 670         


Glu Asp Leu Ile Val Leu Pro Gly Lys Ser His Pro Lys Arg Pro Asn 
        675                 680                 685             


Ser Gln Ser Gln His Thr Lys Thr Gly Leu Ser Ser Ser Ile Leu Leu 
    690                 695                 700                 


Tyr Thr Pro Leu Asn Thr Val Ala Pro Asp Asp Asn Asp Arg Pro Thr 
705                 710                 715                 720 


Thr Asp Met Cys Ser Pro Ala Phe Pro Ile Leu Gly Thr Thr Pro Ala 
                725                 730                 735     


Phe Gly Pro Gln Gly Ser Tyr Glu Lys Ala Ser Thr Glu Val Ala Gly 
            740                 745                 750         


Arg Thr Cys Cys Thr Pro Gln Leu Ala His Leu Lys Asp Ser Val Cys 
        755                 760                 765             


Leu Ala Ser Asp Thr Lys Gln Phe Asp Ser Ser Gly Ser Pro Ala Lys 
    770                 775                 780                 


Pro His Thr Thr Leu Gln Val Ser Gly Arg Gln Gly Gln Pro Thr Cys 
785                 790                 795                 800 


Asp Cys Asp Ser Val Pro Pro Gly Thr Pro Pro Pro Ile Glu Ser Phe 
                805                 810                 815     


Thr Phe Lys Glu Asn Gln Leu Cys Arg Asn Thr Cys Gln Glu Leu His 
            820                 825                 830         


Lys His Ser Val Glu Gln Thr Glu Thr Ala Glu Leu Pro Ala Ser Asp 
        835                 840                 845             


Ser Ile Asn Pro Gly Asn Leu Gln Leu Val Ser Glu Leu Lys Asn Pro 
    850                 855                 860                 


Ser Gly Ser Cys Ser Val Asp Val Ser Ala Met Phe Trp Glu Arg Ala 
865                 870                 875                 880 


Gly Cys Lys Glu Pro Cys Ile Ile Thr Ala Cys Glu Asp Val Val Ser 
                885                 890                 895     


Leu Trp Lys Ala Leu Asp Ala Trp Gln Trp Glu Lys Leu Tyr Thr Trp 
            900                 905                 910         


His Phe Ala Glu Val Pro Val Leu Gln Ile Val Pro Val Pro Asp Val 
        915                 920                 925             


Tyr Asn Leu Val Cys Val Ala Leu Gly Asn Leu Glu Ile Arg Glu Ile 
    930                 935                 940                 


Arg Ala Leu Phe Cys Ser Ser Asp Asp Glu Ser Glu Lys Gln Val Leu 
945                 950                 955                 960 


Leu Lys Ser Gly Asn Ile Lys Ala Val Leu Gly Leu Thr Lys Arg Arg 
                965                 970                 975     


Leu Val Ser Ser Ser Gly Thr Leu Ser Asp Gln Gln Val Glu Val Met 
            980                 985                 990         


Thr Phe Ala Glu Asp Gly Gly Gly  Lys Glu Asn Gln Phe  Leu Met Pro 
        995                 1000                 1005             


Pro Glu  Glu Thr Ile Leu Thr  Phe Ala Glu Val Gln  Gly Met Gln 
    1010                 1015                 1020             


Glu Ala  Leu Leu Gly Thr Thr  Ile Met Asn Asn Ile  Val Ile Trp 
    1025                 1030                 1035             


Asn Leu  Lys Thr Gly Gln Leu  Leu Lys Lys Met His  Ile Asp Asp 
    1040                 1045                 1050             


Ser Tyr  Gln Ala Ser Val Cys  His Lys Ala Tyr Ser  Glu Met Gly 
    1055                 1060                 1065             


Leu Leu  Phe Ile Val Leu Ser  His Pro Cys Ala Lys  Glu Ser Glu 
    1070                 1075                 1080             


Ser Leu  Arg Ser Pro Val Phe  Gln Leu Ile Val Ile  Asn Pro Lys 
    1085                 1090                 1095             


Thr Thr  Leu Ser Val Gly Val  Met Leu Tyr Cys Leu  Pro Pro Gly 
    1100                 1105                 1110             


Gln Ala  Gly Arg Phe Leu Glu  Gly Asp Val Lys Asp  His Cys Ala 
    1115                 1120                 1125             


Ala Ala  Ile Leu Thr Ser Gly  Thr Ile Ala Ile Trp  Asp Leu Leu 
    1130                 1135                 1140             


Leu Gly  Gln Cys Thr Ala Leu  Leu Pro Pro Val Ser  Asp Gln His 
    1145                 1150                 1155             


Trp Ser  Phe Val Lys Trp Ser  Gly Thr Asp Ser His  Leu Leu Ala 
    1160                 1165                 1170             


Gly Gln  Lys Asp Gly Asn Ile  Phe Val Tyr His Tyr  Ser 
    1175                 1180                 1185     


<210>  15
<211>  708
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  15

Met Ser Thr Ala Asp Ala Leu Asp Asp Glu Asn Thr Phe Lys Ile Leu 
1               5                   10                  15      


Val Ala Thr Asp Ile His Leu Gly Phe Met Glu Lys Asp Ala Val Arg 
            20                  25                  30          


Gly Asn Asp Thr Phe Val Thr Leu Asp Glu Ile Leu Arg Leu Ala Gln 
        35                  40                  45              


Glu Asn Glu Val Asp Phe Ile Leu Leu Gly Gly Asp Leu Phe His Glu 
    50                  55                  60                  


Asn Lys Pro Ser Arg Lys Thr Leu His Thr Cys Leu Glu Leu Leu Arg 
65                  70                  75                  80  


Lys Tyr Cys Met Gly Asp Arg Pro Val Gln Phe Glu Ile Leu Ser Asp 
                85                  90                  95      


Gln Ser Val Asn Phe Gly Phe Ser Lys Phe Pro Trp Val Asn Tyr Gln 
            100                 105                 110         


Asp Gly Asn Leu Asn Ile Ser Ile Pro Val Phe Ser Ile His Gly Asn 
        115                 120                 125             


His Asp Asp Pro Thr Gly Ala Asp Ala Leu Cys Ala Leu Asp Ile Leu 
    130                 135                 140                 


Ser Cys Ala Gly Phe Val Asn His Phe Gly Arg Ser Met Ser Val Glu 
145                 150                 155                 160 


Lys Ile Asp Ile Ser Pro Val Leu Leu Gln Lys Gly Ser Thr Lys Ile 
                165                 170                 175     


Ala Leu Tyr Gly Leu Gly Ser Ile Pro Asp Glu Arg Leu Tyr Arg Met 
            180                 185                 190         


Phe Val Asn Lys Lys Val Thr Met Leu Arg Pro Lys Glu Asp Glu Asn 
        195                 200                 205             


Ser Trp Phe Asn Leu Phe Val Ile His Gln Asn Arg Ser Lys His Gly 
    210                 215                 220                 


Ser Thr Asn Phe Ile Pro Glu Gln Phe Leu Asp Asp Phe Ile Asp Leu 
225                 230                 235                 240 


Val Ile Trp Gly His Glu His Glu Cys Lys Ile Ala Pro Thr Lys Asn 
                245                 250                 255     


Glu Gln Gln Leu Phe Tyr Ile Ser Gln Pro Gly Ser Ser Val Val Thr 
            260                 265                 270         


Ser Leu Ser Pro Gly Glu Ala Val Lys Lys His Val Gly Leu Leu Arg 
        275                 280                 285             


Ile Lys Gly Arg Lys Met Asn Met His Lys Ile Pro Leu His Thr Val 
    290                 295                 300                 


Arg Gln Phe Phe Met Glu Asp Ile Val Leu Ala Asn His Pro Asp Ile 
305                 310                 315                 320 


Phe Asn Pro Asp Asn Pro Lys Val Thr Gln Ala Ile Gln Ser Phe Cys 
                325                 330                 335     


Leu Glu Lys Ile Glu Glu Met Leu Glu Asn Ala Glu Arg Glu Arg Leu 
            340                 345                 350         


Gly Asn Ser His Gln Pro Glu Lys Pro Leu Val Arg Leu Arg Val Asp 
        355                 360                 365             


Tyr Ser Gly Gly Phe Glu Pro Phe Ser Val Leu Arg Phe Ser Gln Lys 
    370                 375                 380                 


Phe Val Asp Arg Val Ala Asn Pro Lys Asp Ile Ile His Phe Phe Arg 
385                 390                 395                 400 


His Arg Glu Gln Lys Glu Lys Thr Gly Glu Glu Ile Asn Phe Gly Lys 
                405                 410                 415     


Leu Ile Thr Lys Pro Ser Glu Gly Thr Thr Leu Arg Val Glu Asp Leu 
            420                 425                 430         


Val Lys Gln Tyr Phe Gln Thr Ala Glu Lys Asn Val Gln Leu Ser Leu 
        435                 440                 445             


Leu Thr Glu Arg Gly Met Gly Glu Ala Val Gln Glu Phe Val Asp Lys 
    450                 455                 460                 


Glu Glu Lys Asp Ala Ile Glu Glu Leu Val Lys Tyr Gln Leu Glu Lys 
465                 470                 475                 480 


Thr Gln Arg Phe Leu Lys Glu Arg His Ile Asp Ala Leu Glu Asp Lys 
                485                 490                 495     


Ile Asp Glu Glu Val Arg Arg Phe Arg Glu Thr Arg Gln Lys Asn Thr 
            500                 505                 510         


Asn Glu Glu Asp Asp Glu Val Arg Glu Ala Met Thr Arg Ala Arg Ala 
        515                 520                 525             


Leu Arg Ser Gln Ser Glu Glu Ser Ala Ser Ala Phe Ser Ala Asp Asp 
    530                 535                 540                 


Leu Met Ser Ile Asp Leu Ala Glu Gln Met Ala Asn Asp Ser Asp Asp 
545                 550                 555                 560 


Ser Ile Ser Ala Ala Thr Asn Lys Gly Arg Gly Arg Gly Arg Gly Arg 
                565                 570                 575     


Arg Gly Gly Arg Gly Gln Asn Ser Ala Ser Arg Gly Gly Ser Gln Arg 
            580                 585                 590         


Gly Arg Ala Asp Thr Gly Leu Glu Thr Ser Thr Arg Ser Arg Asn Ser 
        595                 600                 605             


Lys Thr Ala Val Ser Ala Ser Arg Asn Met Ser Ile Ile Asp Ala Phe 
    610                 615                 620                 


Lys Ser Thr Arg Gln Gln Pro Ser Arg Asn Val Thr Thr Lys Asn Tyr 
625                 630                 635                 640 


Ser Glu Val Ile Glu Val Asp Glu Ser Asp Val Glu Glu Asp Ile Phe 
                645                 650                 655     


Pro Thr Thr Ser Lys Thr Asp Gln Arg Trp Ser Ser Thr Ser Ser Ser 
            660                 665                 670         


Lys Ile Met Ser Gln Ser Gln Val Ser Lys Gly Val Asp Phe Glu Ser 
        675                 680                 685             


Ser Glu Asp Asp Asp Asp Asp Pro Phe Met Asn Thr Ser Ser Leu Arg 
    690                 695                 700                 


Arg Asn Arg Arg 
705             


<210>  16
<211>  1182
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  16

Met Asp Glu Pro Pro Gly Lys Pro Leu Ser Cys Glu Glu Lys Glu Lys 
1               5                   10                  15      


Leu Lys Glu Lys Leu Ala Phe Leu Lys Arg Glu Tyr Ser Lys Thr Leu 
            20                  25                  30          


Ala Arg Leu Gln Arg Ala Gln Arg Ala Glu Lys Ile Lys His Ser Ile 
        35                  40                  45              


Lys Lys Thr Val Glu Glu Gln Asp Cys Leu Ser Gln Gln Asp Leu Ser 
    50                  55                  60                  


Pro Gln Leu Lys His Ser Glu Pro Lys Asn Lys Ile Cys Val Tyr Asp 
65                  70                  75                  80  


Lys Leu His Ile Lys Thr His Leu Asp Glu Lys Thr Ser Ile Thr Leu 
                85                  90                  95      


Asp Val Gly Pro Glu Ser Phe Asn Pro Gly Asp Gly Pro Gly Gly Leu 
            100                 105                 110         


Pro Ile Gln Arg Thr Asp Asp Thr Gln Glu His Phe Pro His Arg Val 
        115                 120                 125             


Ser Asp Pro Ser Gly Glu Gln Lys Gln Lys Leu Pro Ser Arg Arg Lys 
    130                 135                 140                 


Lys Gln Gln Lys Arg Thr Phe Ile Ser Gln Glu Arg Asp Cys Val Phe 
145                 150                 155                 160 


Gly Thr Asp Ser Leu Arg Leu Ser Gly Lys Arg Leu Lys Glu Gln Glu 
                165                 170                 175     


Glu Ile Ser Ser Lys Asn Pro Ala Arg Ser Pro Val Thr Glu Ile Arg 
            180                 185                 190         


Thr His Leu Leu Ser Leu Lys Ser Glu Leu Pro Asp Ser Pro Glu Pro 
        195                 200                 205             


Val Thr Glu Ile Asn Glu Asp Ser Val Leu Ile Pro Pro Thr Ala Gln 
    210                 215                 220                 


Pro Glu Lys Gly Val Asp Thr Phe Leu Arg Arg Pro Asn Phe Thr Arg 
225                 230                 235                 240 


Ala Thr Thr Val Pro Leu Gln Thr Leu Ser Asp Ser Gly Ser Ser Gln 
                245                 250                 255     


His Leu Glu His Ile Pro Pro Lys Gly Ser Ser Glu Leu Thr Thr His 
            260                 265                 270         


Asp Leu Lys Asn Ile Arg Phe Thr Ser Pro Val Ser Leu Glu Ala Gln 
        275                 280                 285             


Gly Lys Lys Met Thr Val Ser Thr Asp Asn Leu Leu Val Asn Lys Ala 
    290                 295                 300                 


Ile Ser Lys Ser Gly Gln Leu Pro Thr Ser Ser Asn Leu Glu Ala Asn 
305                 310                 315                 320 


Ile Ser Cys Ser Leu Asn Glu Leu Thr Tyr Asn Asn Leu Pro Ala Asn 
                325                 330                 335     


Glu Asn Gln Asn Leu Lys Glu Gln Asn Gln Thr Glu Lys Ser Leu Lys 
            340                 345                 350         


Ser Pro Ser Asp Thr Leu Asp Gly Arg Asn Glu Asn Leu Gln Glu Ser 
        355                 360                 365             


Glu Ile Leu Ser Gln Pro Lys Ser Leu Ser Leu Glu Ala Thr Ser Pro 
    370                 375                 380                 


Leu Ser Ala Glu Lys His Ser Cys Thr Val Pro Glu Gly Leu Leu Phe 
385                 390                 395                 400 


Pro Ala Glu Tyr Tyr Val Arg Thr Thr Arg Ser Met Ser Asn Cys Gln 
                405                 410                 415     


Arg Lys Val Ala Val Glu Ala Val Ile Gln Ser His Leu Asp Val Lys 
            420                 425                 430         


Lys Lys Gly Phe Lys Asn Lys Asn Lys Asp Ala Ser Lys Asn Leu Asn 
        435                 440                 445             


Leu Ser Asn Glu Glu Thr Asp Gln Ser Glu Ile Arg Met Ser Gly Thr 
    450                 455                 460                 


Cys Thr Gly Gln Pro Ser Ser Arg Thr Ser Gln Lys Leu Leu Ser Leu 
465                 470                 475                 480 


Thr Lys Val Ser Ser Pro Ala Gly Pro Thr Glu Asp Asn Asp Leu Ser 
                485                 490                 495     


Arg Lys Ala Val Ala Gln Ala Pro Gly Arg Arg Tyr Thr Gly Lys Arg 
            500                 505                 510         


Lys Ser Ala Cys Thr Pro Ala Ser Asp His Cys Glu Pro Leu Leu Pro 
        515                 520                 525             


Thr Ser Ser Leu Ser Ile Val Asn Arg Ser Lys Glu Glu Val Thr Ser 
    530                 535                 540                 


His Lys Tyr Gln His Glu Lys Leu Phe Ile Gln Val Lys Gly Lys Lys 
545                 550                 555                 560 


Ser Arg His Gln Lys Glu Asp Ser Leu Ser Trp Ser Asn Ser Ala Tyr 
                565                 570                 575     


Leu Ser Leu Asp Asp Asp Ala Phe Thr Ala Pro Phe His Arg Asp Gly 
            580                 585                 590         


Met Leu Ser Leu Lys Gln Leu Leu Ser Phe Leu Ser Ile Thr Asp Phe 
        595                 600                 605             


Gln Leu Pro Asp Glu Asp Phe Gly Pro Leu Lys Leu Glu Lys Val Lys 
    610                 615                 620                 


Ser Cys Ser Glu Lys Pro Val Glu Pro Phe Glu Ser Lys Met Phe Gly 
625                 630                 635                 640 


Glu Arg His Leu Lys Glu Gly Ser Cys Ile Phe Pro Glu Glu Leu Ser 
                645                 650                 655     


Pro Lys Arg Met Asp Thr Glu Met Glu Asp Leu Glu Glu Asp Leu Ile 
            660                 665                 670         


Val Leu Pro Gly Lys Ser His Pro Lys Arg Pro Asn Ser Gln Ser Gln 
        675                 680                 685             


His Thr Lys Thr Gly Leu Ser Ser Ser Ile Leu Leu Tyr Thr Pro Leu 
    690                 695                 700                 


Asn Thr Val Ala Pro Asp Asp Asn Asp Arg Pro Thr Thr Asp Met Cys 
705                 710                 715                 720 


Ser Pro Ala Phe Pro Ile Leu Gly Thr Thr Pro Ala Phe Gly Pro Gln 
                725                 730                 735     


Gly Ser Tyr Glu Lys Ala Ser Thr Glu Val Ala Gly Arg Thr Cys Cys 
            740                 745                 750         


Thr Pro Gln Leu Ala His Leu Lys Asp Ser Val Cys Leu Ala Ser Asp 
        755                 760                 765             


Thr Lys Gln Phe Asp Ser Ser Gly Ser Pro Ala Lys Pro His Thr Thr 
    770                 775                 780                 


Leu Gln Val Ser Gly Arg Gln Gly Gln Pro Thr Cys Asp Cys Asp Ser 
785                 790                 795                 800 


Val Pro Pro Gly Thr Pro Pro Pro Ile Glu Ser Phe Thr Phe Lys Glu 
                805                 810                 815     


Asn Gln Leu Cys Arg Asn Thr Cys Gln Glu Leu His Lys His Ser Val 
            820                 825                 830         


Glu Gln Thr Glu Thr Ala Glu Leu Pro Ala Ser Asp Ser Ile Asn Pro 
        835                 840                 845             


Gly Asn Leu Gln Leu Val Ser Glu Leu Lys Asn Pro Ser Gly Ser Cys 
    850                 855                 860                 


Ser Val Asp Val Ser Ala Met Phe Trp Glu Arg Ala Gly Cys Lys Glu 
865                 870                 875                 880 


Pro Cys Ile Ile Thr Ala Cys Glu Asp Val Val Ser Leu Trp Lys Ala 
                885                 890                 895     


Leu Asp Ala Trp Gln Trp Glu Lys Leu Tyr Thr Trp His Phe Ala Glu 
            900                 905                 910         


Val Pro Val Leu Gln Ile Val Pro Val Pro Asp Val Tyr Asn Leu Val 
        915                 920                 925             


Cys Val Ala Leu Gly Asn Leu Glu Ile Arg Glu Ile Arg Ala Leu Phe 
    930                 935                 940                 


Cys Ser Ser Asp Asp Glu Ser Glu Lys Gln Val Leu Leu Lys Ser Gly 
945                 950                 955                 960 


Asn Ile Lys Ala Val Leu Gly Leu Thr Lys Arg Arg Leu Val Ser Ser 
                965                 970                 975     


Ser Gly Thr Leu Ser Asp Gln Gln Val Glu Val Met Thr Phe Ala Glu 
            980                 985                 990         


Asp Gly Gly Gly Lys Glu Asn Gln  Phe Leu Met Pro Pro  Glu Glu Thr 
        995                 1000                 1005             


Ile Leu  Thr Phe Ala Glu Val  Gln Gly Met Gln Glu  Ala Leu Leu 
    1010                 1015                 1020             


Gly Thr  Thr Ile Met Asn Asn  Ile Val Ile Trp Asn  Leu Lys Thr 
    1025                 1030                 1035             


Gly Gln  Leu Leu Lys Lys Met  His Ile Asp Asp Ser  Tyr Gln Ala 
    1040                 1045                 1050             


Ser Val  Cys His Lys Ala Tyr  Ser Glu Met Gly Leu  Leu Phe Ile 
    1055                 1060                 1065             


Val Leu  Ser His Pro Cys Ala  Lys Glu Ser Glu Ser  Leu Arg Ser 
    1070                 1075                 1080             


Pro Val  Phe Gln Leu Ile Val  Ile Asn Pro Lys Thr  Thr Leu Ser 
    1085                 1090                 1095             


Val Gly  Val Met Leu Tyr Cys  Leu Pro Pro Gly Gln  Ala Gly Arg 
    1100                 1105                 1110             


Phe Leu  Glu Gly Asp Val Lys  Asp His Cys Ala Ala  Ala Ile Leu 
    1115                 1120                 1125             


Thr Ser  Gly Thr Ile Ala Ile  Trp Asp Leu Leu Leu  Gly Gln Cys 
    1130                 1135                 1140             


Thr Ala  Leu Leu Pro Pro Val  Ser Asp Gln His Trp  Ser Phe Val 
    1145                 1150                 1155             


Lys Trp  Ser Gly Thr Asp Ser  His Leu Leu Ala Gly  Gln Lys Asp 
    1160                 1165                 1170             


Gly Asn  Ile Phe Val Tyr His  Tyr Ser 
    1175                 1180         


<210>  17
<211>  197
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  17

Met Gln Arg Ala Ser Arg Leu Lys Arg Glu Leu His Met Leu Ala Thr 
1               5                   10                  15      


Glu Pro Pro Pro Gly Ile Thr Cys Trp Gln Asp Lys Asp Gln Met Asp 
            20                  25                  30          


Asp Leu Arg Ala Gln Ile Leu Gly Gly Ala Asn Thr Pro Tyr Glu Lys 
        35                  40                  45              


Gly Val Phe Lys Leu Glu Val Ile Ile Pro Glu Arg Tyr Pro Phe Glu 
    50                  55                  60                  


Pro Pro Gln Ile Arg Phe Leu Thr Pro Ile Tyr His Pro Asn Ile Asp 
65                  70                  75                  80  


Ser Ala Gly Arg Ile Cys Leu Asp Val Leu Lys Leu Pro Pro Lys Gly 
                85                  90                  95      


Ala Trp Arg Pro Ser Leu Asn Ile Ala Thr Val Leu Thr Ser Ile Gln 
            100                 105                 110         


Leu Leu Met Ser Glu Pro Asn Pro Asp Asp Pro Leu Met Ala Asp Ile 
        115                 120                 125             


Ser Ser Glu Phe Lys Tyr Asn Lys Pro Ala Phe Leu Lys Asn Ala Arg 
    130                 135                 140                 


Gln Trp Thr Glu Lys His Ala Arg Gln Lys Gln Lys Ala Asp Glu Glu 
145                 150                 155                 160 


Glu Met Leu Asp Asn Leu Pro Glu Ala Gly Asp Ser Arg Val His Asn 
                165                 170                 175     


Ser Thr Gln Lys Arg Lys Ala Ser Gln Leu Val Gly Ile Glu Lys Lys 
            180                 185                 190         


Phe His Pro Asp Val 
        195         


<210>  18
<211>  897
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  18

Met Asn Ile Ser Gly Ser Ser Cys Gly Ser Pro Asn Ser Ala Asp Thr 
1               5                   10                  15      


Ser Ser Asp Phe Lys Asp Leu Trp Thr Lys Leu Lys Glu Cys His Asp 
            20                  25                  30          


Arg Glu Val Gln Gly Leu Gln Val Lys Val Thr Lys Leu Lys Gln Glu 
        35                  40                  45              


Arg Ile Leu Asp Ala Gln Arg Leu Glu Glu Phe Phe Thr Lys Asn Gln 
    50                  55                  60                  


Gln Leu Arg Glu Gln Gln Lys Val Leu His Glu Thr Ile Lys Val Leu 
65                  70                  75                  80  


Glu Asp Arg Leu Arg Ala Gly Leu Cys Asp Arg Cys Ala Val Thr Glu 
                85                  90                  95      


Glu His Met Arg Lys Lys Gln Gln Glu Phe Glu Asn Ile Arg Gln Gln 
            100                 105                 110         


Asn Leu Lys Leu Ile Thr Glu Leu Met Asn Glu Arg Asn Thr Leu Gln 
        115                 120                 125             


Glu Glu Asn Lys Lys Leu Ser Glu Gln Leu Gln Gln Lys Ile Glu Asn 
    130                 135                 140                 


Asp Gln Gln His Gln Ala Ala Glu Leu Glu Cys Glu Glu Asp Val Ile 
145                 150                 155                 160 


Pro Asp Ser Pro Ile Thr Ala Phe Ser Phe Ser Gly Val Asn Arg Leu 
                165                 170                 175     


Arg Arg Lys Glu Asn Pro His Val Arg Tyr Ile Glu Gln Thr His Thr 
            180                 185                 190         


Lys Leu Glu His Ser Val Cys Ala Asn Glu Met Arg Lys Val Ser Lys 
        195                 200                 205             


Ser Ser Thr His Pro Gln His Asn Pro Asn Glu Asn Glu Ile Leu Val 
    210                 215                 220                 


Ala Asp Thr Tyr Asp Gln Ser Gln Ser Pro Met Ala Lys Ala His Gly 
225                 230                 235                 240 


Thr Ser Ser Tyr Thr Pro Asp Lys Ser Ser Phe Asn Leu Ala Thr Val 
                245                 250                 255     


Val Ala Glu Thr Leu Gly Leu Gly Val Gln Glu Glu Ser Glu Thr Gln 
            260                 265                 270         


Gly Pro Met Ser Pro Leu Gly Asp Glu Leu Tyr His Cys Leu Glu Gly 
        275                 280                 285             


Asn His Lys Lys Gln Pro Phe Glu Glu Ser Thr Arg Asn Thr Glu Asp 
    290                 295                 300                 


Ser Leu Arg Phe Ser Asp Ser Thr Ser Lys Thr Pro Pro Gln Glu Glu 
305                 310                 315                 320 


Leu Pro Thr Arg Val Ser Ser Pro Val Phe Gly Ala Thr Ser Ser Ile 
                325                 330                 335     


Lys Ser Gly Leu Asp Leu Asn Thr Ser Leu Ser Pro Ser Leu Leu Gln 
            340                 345                 350         


Pro Gly Lys Lys Lys His Leu Lys Thr Leu Pro Phe Ser Asn Thr Cys 
        355                 360                 365             


Ile Ser Arg Leu Glu Lys Thr Arg Ser Lys Ser Glu Asp Ser Ala Leu 
    370                 375                 380                 


Phe Thr His His Ser Leu Gly Ser Glu Val Asn Lys Ile Ile Ile Gln 
385                 390                 395                 400 


Ser Ser Asn Lys Gln Ile Leu Ile Asn Lys Asn Ile Ser Glu Ser Leu 
                405                 410                 415     


Gly Glu Gln Asn Arg Thr Glu Tyr Gly Lys Asp Ser Asn Thr Asp Lys 
            420                 425                 430         


His Leu Glu Pro Leu Lys Ser Leu Gly Gly Arg Thr Ser Lys Arg Lys 
        435                 440                 445             


Lys Thr Glu Glu Glu Ser Glu His Glu Val Ser Cys Pro Gln Ala Ser 
    450                 455                 460                 


Phe Asp Lys Glu Asn Ala Phe Pro Phe Pro Met Asp Asn Gln Phe Ser 
465                 470                 475                 480 


Met Asn Gly Asp Cys Val Met Asp Lys Pro Leu Asp Leu Ser Asp Arg 
                485                 490                 495     


Phe Ser Ala Ile Gln Arg Gln Glu Lys Ser Gln Gly Ser Glu Thr Ser 
            500                 505                 510         


Lys Asn Lys Phe Arg Gln Val Thr Leu Tyr Glu Ala Leu Lys Thr Ile 
        515                 520                 525             


Pro Lys Gly Phe Ser Ser Ser Arg Lys Ala Ser Asp Gly Asn Cys Thr 
    530                 535                 540                 


Leu Pro Lys Asp Ser Pro Gly Glu Pro Cys Ser Gln Glu Cys Ile Ile 
545                 550                 555                 560 


Leu Gln Pro Leu Asn Lys Cys Ser Pro Asp Asn Lys Pro Ser Leu Gln 
                565                 570                 575     


Ile Lys Glu Glu Asn Ala Val Phe Lys Ile Pro Leu Arg Pro Arg Glu 
            580                 585                 590         


Ser Leu Glu Thr Glu Asn Val Leu Asp Asp Ile Lys Ser Ala Gly Ser 
        595                 600                 605             


His Glu Pro Ile Lys Ile Gln Thr Arg Ser Asp His Gly Gly Cys Glu 
    610                 615                 620                 


Leu Ala Ser Val Leu Gln Leu Asn Pro Cys Arg Thr Gly Lys Ile Lys 
625                 630                 635                 640 


Ser Leu Gln Asn Asn Gln Asp Val Ser Phe Glu Asn Ile Gln Trp Ser 
                645                 650                 655     


Ile Asp Pro Gly Ala Asp Leu Ser Gln Tyr Lys Met Asp Val Thr Val 
            660                 665                 670         


Ile Asp Thr Lys Asp Gly Ser Gln Ser Lys Leu Gly Gly Glu Thr Val 
        675                 680                 685             


Asp Met Asp Cys Thr Leu Val Ser Glu Thr Val Leu Leu Lys Met Lys 
    690                 695                 700                 


Lys Gln Glu Gln Lys Gly Glu Lys Ser Ser Asn Glu Glu Arg Lys Met 
705                 710                 715                 720 


Asn Asp Ser Leu Glu Asp Met Phe Asp Arg Thr Thr His Glu Glu Tyr 
                725                 730                 735     


Glu Ser Cys Leu Ala Asp Ser Phe Ser Gln Ala Ala Asp Glu Glu Glu 
            740                 745                 750         


Glu Leu Ser Thr Ala Thr Lys Lys Leu His Thr His Gly Asp Lys Gln 
        755                 760                 765             


Asp Lys Val Lys Gln Lys Ala Phe Val Glu Pro Tyr Phe Lys Gly Asp 
    770                 775                 780                 


Glu Arg Glu Thr Ser Leu Gln Asn Phe Pro His Ile Glu Val Val Arg 
785                 790                 795                 800 


Lys Lys Glu Glu Arg Arg Lys Leu Leu Gly His Thr Cys Lys Glu Cys 
                805                 810                 815     


Glu Ile Tyr Tyr Ala Asp Met Pro Ala Glu Glu Arg Glu Lys Lys Leu 
            820                 825                 830         


Ala Ser Cys Ser Arg His Arg Phe Arg Tyr Ile Pro Pro Asn Thr Pro 
        835                 840                 845             


Glu Asn Phe Trp Glu Val Gly Phe Pro Ser Thr Gln Thr Cys Met Glu 
    850                 855                 860                 


Arg Gly Tyr Ile Lys Glu Asp Leu Asp Pro Cys Pro Arg Pro Lys Arg 
865                 870                 875                 880 


Arg Gln Pro Tyr Asn Ala Ile Phe Ser Pro Lys Gly Lys Glu Gln Lys 
                885                 890                 895     


Thr 
    


<210>  19
<211>  785
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  19

Met Pro Gly Val Ile Pro Ser Glu Ser Asn Gly Leu Ser Arg Gly Ser 
1               5                   10                  15      


Pro Ser Lys Lys Asn Arg Leu Ser Leu Lys Phe Phe Gln Lys Lys Glu 
            20                  25                  30          


Thr Lys Arg Ala Leu Asp Phe Thr Asp Ser Gln Glu Asn Glu Glu Lys 
        35                  40                  45              


Ala Ser Glu Tyr Arg Ala Ser Glu Ile Asp Gln Val Val Pro Ala Ala 
    50                  55                  60                  


Gln Ser Ser Pro Ile Asn Cys Glu Lys Arg Glu Asn Leu Leu Pro Phe 
65                  70                  75                  80  


Val Gly Leu Asn Asn Leu Gly Asn Thr Cys Tyr Leu Asn Ser Ile Leu 
                85                  90                  95      


Gln Val Leu Tyr Phe Cys Pro Gly Phe Lys Ser Gly Val Lys His Leu 
            100                 105                 110         


Phe Asn Ile Ile Ser Arg Lys Lys Glu Ala Leu Lys Asp Glu Ala Asn 
        115                 120                 125             


Gln Lys Asp Lys Gly Asn Cys Lys Glu Asp Ser Leu Ala Ser Tyr Glu 
    130                 135                 140                 


Leu Ile Cys Ser Leu Gln Ser Leu Ile Ile Ser Val Glu Gln Leu Gln 
145                 150                 155                 160 


Ala Ser Phe Leu Leu Asn Pro Glu Lys Tyr Thr Asp Glu Leu Ala Thr 
                165                 170                 175     


Gln Pro Arg Arg Leu Leu Asn Thr Leu Arg Glu Leu Asn Pro Met Tyr 
            180                 185                 190         


Glu Gly Tyr Leu Gln His Asp Ala Gln Glu Val Leu Gln Cys Ile Leu 
        195                 200                 205             


Gly Asn Ile Gln Glu Thr Cys Gln Leu Leu Lys Lys Glu Glu Val Lys 
    210                 215                 220                 


Asn Val Ala Glu Leu Pro Thr Lys Val Glu Glu Ile Pro His Pro Lys 
225                 230                 235                 240 


Glu Glu Met Asn Gly Ile Asn Ser Ile Glu Met Asp Ser Met Arg His 
                245                 250                 255     


Ser Glu Asp Phe Lys Glu Lys Leu Pro Lys Gly Asn Gly Lys Arg Lys 
            260                 265                 270         


Ser Asp Thr Glu Phe Gly Asn Met Lys Lys Lys Val Lys Leu Ser Lys 
        275                 280                 285             


Glu His Gln Ser Leu Glu Glu Asn Gln Arg Gln Thr Arg Ser Lys Arg 
    290                 295                 300                 


Lys Ala Thr Ser Asp Thr Leu Glu Ser Pro Pro Lys Ile Ile Pro Lys 
305                 310                 315                 320 


Tyr Ile Ser Glu Asn Glu Ser Pro Arg Pro Ser Gln Lys Lys Ser Arg 
                325                 330                 335     


Val Lys Ile Asn Trp Leu Lys Ser Ala Thr Lys Gln Pro Ser Ile Leu 
            340                 345                 350         


Ser Lys Phe Cys Ser Leu Gly Lys Ile Thr Thr Asn Gln Gly Val Lys 
        355                 360                 365             


Gly Gln Ser Lys Glu Asn Glu Cys Asp Pro Glu Glu Asp Leu Gly Lys 
    370                 375                 380                 


Cys Glu Ser Asp Asn Thr Thr Asn Gly Cys Gly Leu Glu Ser Pro Gly 
385                 390                 395                 400 


Asn Thr Val Thr Pro Val Asn Val Asn Glu Val Lys Pro Ile Asn Lys 
                405                 410                 415     


Gly Glu Glu Gln Ile Gly Phe Glu Leu Val Glu Lys Leu Phe Gln Gly 
            420                 425                 430         


Gln Leu Val Leu Arg Thr Arg Cys Leu Glu Cys Glu Ser Leu Thr Glu 
        435                 440                 445             


Arg Arg Glu Asp Phe Gln Asp Ile Ser Val Pro Val Gln Glu Asp Glu 
    450                 455                 460                 


Leu Ser Lys Val Glu Glu Ser Ser Glu Ile Ser Pro Glu Pro Lys Thr 
465                 470                 475                 480 


Glu Met Lys Thr Leu Arg Trp Ala Ile Ser Gln Phe Ala Ser Val Glu 
                485                 490                 495     


Arg Ile Val Gly Glu Asp Lys Tyr Phe Cys Glu Asn Cys His His Tyr 
            500                 505                 510         


Thr Glu Ala Glu Arg Ser Leu Leu Phe Asp Lys Met Pro Glu Val Ile 
        515                 520                 525             


Thr Ile His Leu Lys Cys Phe Ala Ala Ser Gly Leu Glu Phe Asp Cys 
    530                 535                 540                 


Tyr Gly Gly Gly Leu Ser Lys Ile Asn Thr Pro Leu Leu Thr Pro Leu 
545                 550                 555                 560 


Lys Leu Ser Leu Glu Glu Trp Ser Thr Lys Pro Thr Asn Asp Ser Tyr 
                565                 570                 575     


Gly Leu Phe Ala Val Val Met His Ser Gly Ile Thr Ile Ser Ser Gly 
            580                 585                 590         


His Tyr Thr Ala Ser Val Lys Val Thr Asp Leu Asn Ser Leu Glu Leu 
        595                 600                 605             


Asp Lys Gly Asn Phe Val Val Asp Gln Met Cys Glu Ile Gly Lys Pro 
    610                 615                 620                 


Glu Pro Leu Asn Glu Glu Glu Ala Arg Gly Val Val Glu Asn Tyr Asn 
625                 630                 635                 640 


Asp Glu Glu Val Ser Ile Arg Val Gly Gly Asn Thr Gln Pro Ser Lys 
                645                 650                 655     


Val Leu Asn Lys Lys Asn Val Glu Ala Ile Gly Leu Leu Gly Gly Gln 
            660                 665                 670         


Lys Ser Lys Ala Asp Tyr Glu Leu Tyr Asn Lys Ala Ser Asn Pro Asp 
        675                 680                 685             


Lys Val Ala Ser Thr Ala Phe Ala Glu Asn Arg Asn Ser Glu Thr Ser 
    690                 695                 700                 


Asp Thr Thr Gly Thr His Glu Ser Asp Arg Asn Lys Glu Ser Ser Asp 
705                 710                 715                 720 


Gln Thr Gly Ile Asn Ile Ser Gly Phe Glu Asn Lys Ile Ser Tyr Val 
                725                 730                 735     


Val Gln Ser Leu Lys Glu Tyr Glu Gly Lys Trp Leu Leu Phe Asp Asp 
            740                 745                 750         


Ser Glu Val Lys Val Thr Glu Glu Lys Asp Phe Leu Asn Ser Leu Ser 
        755                 760                 765             


Pro Ser Thr Ser Pro Thr Ser Thr Pro Tyr Leu Leu Phe Tyr Lys Lys 
    770                 775                 780                 


Leu 
785 


<210>  20
<211>  270
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  20

Met Trp Asn Ser Gly Phe Glu Ser Tyr Gly Ser Ser Ser Tyr Gly Gly 
1               5                   10                  15      


Ala Gly Gly Tyr Thr Gln Ser Pro Gly Gly Phe Gly Ser Pro Ala Pro 
            20                  25                  30          


Ser Gln Ala Glu Lys Lys Ser Arg Ala Arg Ala Gln His Ile Val Pro 
        35                  40                  45              


Cys Thr Ile Ser Gln Leu Leu Ser Ala Thr Leu Val Asp Glu Val Phe 
    50                  55                  60                  


Arg Ile Gly Asn Val Glu Ile Ser Gln Val Thr Ile Val Gly Ile Ile 
65                  70                  75                  80  


Arg His Ala Glu Lys Ala Pro Thr Asn Ile Val Tyr Lys Ile Asp Asp 
                85                  90                  95      


Met Thr Ala Ala Pro Met Asp Val Arg Gln Trp Val Asp Thr Asp Asp 
            100                 105                 110         


Thr Ser Ser Glu Asn Thr Val Val Pro Pro Glu Thr Tyr Val Lys Val 
        115                 120                 125             


Ala Gly His Leu Arg Ser Phe Gln Asn Lys Lys Ser Leu Val Ala Phe 
    130                 135                 140                 


Lys Ile Met Pro Leu Glu Asp Met Asn Glu Phe Thr Thr His Ile Leu 
145                 150                 155                 160 


Glu Val Ile Asn Ala His Met Val Leu Ser Lys Ala Asn Ser Gln Pro 
                165                 170                 175     


Ser Ala Gly Arg Ala Pro Ile Ser Asn Pro Gly Met Ser Glu Ala Gly 
            180                 185                 190         


Asn Phe Gly Gly Asn Ser Phe Met Pro Ala Asn Gly Leu Thr Val Ala 
        195                 200                 205             


Gln Asn Gln Val Leu Asn Leu Ile Lys Ala Cys Pro Arg Pro Glu Gly 
    210                 215                 220                 


Leu Asn Phe Gln Asp Leu Lys Asn Gln Leu Lys His Met Ser Val Ser 
225                 230                 235                 240 


Ser Ile Lys Gln Ala Val Asp Phe Leu Ser Asn Glu Gly His Ile Tyr 
                245                 250                 255     


Ser Thr Val Asp Asp Asp His Phe Lys Ser Thr Asp Ala Glu 
            260                 265                 270 


<210>  21
<211>  69
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  21

Glu Gln Asn Ile Lys Asp Phe Glu Thr Ser Asp Thr Phe Phe Gln Thr 
1               5                   10                  15      


Ala Ser Gly Lys Asn Ile Ser Val Ala Lys Glu Ser Phe Asn Lys Ile 
            20                  25                  30          


Val Asn Phe Phe Asp Gln Lys Pro Glu Glu Leu His Asn Phe Ser Leu 
        35                  40                  45              


Asn Ser Glu Leu His Ser Asp Ile Arg Lys Asn Lys Met Asp Ile Leu 
    50                  55                  60                  


Ser Tyr Glu Glu Thr 
65                  


<210>  22
<211>  121
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  22

Met Val Asp Met Met Asp Leu Pro Arg Ser Arg Ile Asn Ala Gly Met 
1               5                   10                  15      


Leu Ala Gln Phe Ile Asp Lys Pro Val Cys Phe Val Gly Arg Leu Glu 
            20                  25                  30          


Lys Ile His Pro Thr Gly Lys Met Phe Ile Leu Ser Asp Gly Glu Gly 
        35                  40                  45              


Lys Asn Gly Thr Ile Glu Leu Met Glu Pro Leu Asp Glu Glu Ile Ser 
    50                  55                  60                  


Gly Ile Val Glu Val Val Gly Arg Val Thr Ala Lys Ala Thr Ile Leu 
65                  70                  75                  80  


Cys Thr Ser Tyr Val Gln Phe Lys Glu Asp Ser His Pro Phe Asp Leu 
                85                  90                  95      


Gly Leu Tyr Asn Glu Ala Val Lys Ile Ile His Asp Phe Pro Gln Phe 
            100                 105                 110         


Tyr Pro Leu Gly Ile Val Gln His Asp 
        115                 120     


<210>  23
<211>  69
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  23

Glu Arg Asp Glu Lys Ile Lys Glu Pro Thr Leu Leu Gly Phe His Thr 
1               5                   10                  15      


Ala Ser Gly Lys Lys Val Lys Ile Ala Lys Glu Ser Leu Asp Lys Val 
            20                  25                  30          


Lys Asn Leu Phe Asp Glu Lys Glu Gln Gly Thr Ser Glu Ile Thr Ser 
        35                  40                  45              


Phe Ser His Gln Trp Ala Lys Thr Leu Lys Tyr Arg Glu Ala Cys Lys 
    50                  55                  60                  


Asp Leu Glu Leu Ala 
65                  


<210>  24
<211>  616
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  24

Met Val Gly Gln Leu Ser Glu Gly Ala Ile Ala Ala Ile Met Gln Lys 
1               5                   10                  15      


Gly Asp Thr Asn Ile Lys Pro Ile Leu Gln Val Ile Asn Ile Arg Pro 
            20                  25                  30          


Ile Thr Thr Gly Asn Ser Pro Pro Arg Tyr Arg Leu Leu Met Ser Asp 
        35                  40                  45              


Gly Leu Asn Thr Leu Ser Ser Phe Met Leu Ala Thr Gln Leu Asn Pro 
    50                  55                  60                  


Leu Val Glu Glu Glu Gln Leu Ser Ser Asn Cys Val Cys Gln Ile His 
65                  70                  75                  80  


Arg Phe Ile Val Asn Thr Leu Lys Asp Gly Arg Arg Val Val Ile Leu 
                85                  90                  95      


Met Glu Leu Glu Val Leu Lys Ser Ala Glu Ala Val Gly Val Lys Ile 
            100                 105                 110         


Gly Asn Pro Val Pro Tyr Asn Glu Gly Leu Gly Gln Pro Gln Val Ala 
        115                 120                 125             


Pro Pro Ala Pro Ala Ala Ser Pro Ala Ala Ser Ser Arg Pro Gln Pro 
    130                 135                 140                 


Gln Asn Gly Ser Ser Gly Met Gly Ser Thr Val Ser Lys Ala Tyr Gly 
145                 150                 155                 160 


Ala Ser Lys Thr Phe Gly Lys Ala Ala Gly Pro Ser Leu Ser His Thr 
                165                 170                 175     


Ser Gly Gly Thr Gln Ser Lys Val Val Pro Ile Ala Ser Leu Thr Pro 
            180                 185                 190         


Tyr Gln Ser Lys Trp Thr Ile Cys Ala Arg Val Thr Asn Lys Ser Gln 
        195                 200                 205             


Ile Arg Thr Trp Ser Asn Ser Arg Gly Glu Gly Lys Leu Phe Ser Leu 
    210                 215                 220                 


Glu Leu Val Asp Glu Ser Gly Glu Ile Arg Ala Thr Ala Phe Asn Glu 
225                 230                 235                 240 


Gln Val Asp Lys Phe Phe Pro Leu Ile Glu Val Asn Lys Val Tyr Tyr 
                245                 250                 255     


Phe Ser Lys Gly Thr Leu Lys Ile Ala Asn Lys Gln Phe Thr Ala Val 
            260                 265                 270         


Lys Asn Asp Tyr Glu Met Thr Phe Asn Asn Glu Thr Ser Val Met Pro 
        275                 280                 285             


Cys Glu Asp Asp His His Leu Pro Thr Val Gln Phe Asp Phe Thr Gly 
    290                 295                 300                 


Ile Asp Asp Leu Glu Asn Lys Ser Lys Asp Ser Leu Val Asp Ile Ile 
305                 310                 315                 320 


Gly Ile Cys Lys Ser Tyr Glu Asp Ala Thr Lys Ile Thr Val Arg Ser 
                325                 330                 335     


Asn Asn Arg Glu Val Ala Lys Arg Asn Ile Tyr Leu Met Asp Thr Ser 
            340                 345                 350         


Gly Lys Val Val Thr Ala Thr Leu Trp Gly Glu Asp Ala Asp Lys Phe 
        355                 360                 365             


Asp Gly Ser Arg Gln Pro Val Leu Ala Ile Lys Gly Ala Arg Val Ser 
    370                 375                 380                 


Asp Phe Gly Gly Arg Ser Leu Ser Val Leu Ser Ser Ser Thr Ile Ile 
385                 390                 395                 400 


Ala Asn Pro Asp Ile Pro Glu Ala Tyr Lys Leu Arg Gly Trp Phe Asp 
                405                 410                 415     


Ala Glu Gly Gln Ala Leu Asp Gly Val Ser Ile Ser Asp Leu Lys Ser 
            420                 425                 430         


Gly Gly Val Gly Gly Ser Asn Thr Asn Trp Lys Thr Leu Tyr Glu Val 
        435                 440                 445             


Lys Ser Glu Asn Leu Gly Gln Gly Asp Lys Pro Asp Tyr Phe Ser Ser 
    450                 455                 460                 


Val Ala Thr Val Val Tyr Leu Arg Lys Glu Asn Cys Met Tyr Gln Ala 
465                 470                 475                 480 


Cys Pro Thr Gln Asp Cys Asn Lys Lys Val Ile Asp Gln Gln Asn Gly 
                485                 490                 495     


Leu Tyr Arg Cys Glu Lys Cys Asp Thr Glu Phe Pro Asn Phe Lys Tyr 
            500                 505                 510         


Arg Met Ile Leu Ser Val Asn Ile Ala Asp Phe Gln Glu Asn Gln Trp 
        515                 520                 525             


Val Thr Cys Phe Gln Glu Ser Ala Glu Ala Ile Leu Gly Gln Asn Ala 
    530                 535                 540                 


Ala Tyr Leu Gly Glu Leu Lys Asp Lys Asn Glu Gln Ala Phe Glu Glu 
545                 550                 555                 560 


Val Phe Gln Asn Ala Asn Phe Arg Ser Phe Ile Phe Arg Val Arg Val 
                565                 570                 575     


Lys Val Glu Thr Tyr Asn Asp Glu Ser Arg Ile Lys Ala Thr Val Met 
            580                 585                 590         


Asp Val Lys Pro Val Asp Tyr Arg Glu Tyr Gly Arg Arg Leu Val Met 
        595                 600                 605             


Ser Ile Arg Arg Ser Ala Leu Met 
    610                 615     


<210>  25
<211>  1435
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  25

Met Ile Asp Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
1               5                   10                  15      


Gly Ser Met Tyr Pro Tyr Asp Val Pro Asp Tyr Ala Ser Pro Lys Lys 
            20                  25                  30          


Lys Arg Lys Val Glu Ala Ser Asp Lys Lys Tyr Ser Ile Gly Leu Asp 
        35                  40                  45              


Ile Gly Thr Asn Ser Val Gly Trp Ala Val Ile Thr Asp Glu Tyr Lys 
    50                  55                  60                  


Val Pro Ser Lys Lys Phe Lys Val Leu Gly Asn Thr Asp Arg His Ser 
65                  70                  75                  80  


Ile Lys Lys Asn Leu Ile Gly Ala Leu Leu Phe Asp Ser Gly Glu Thr 
                85                  90                  95      


Ala Glu Ala Thr Arg Leu Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg 
            100                 105                 110         


Arg Lys Asn Arg Ile Cys Tyr Leu Gln Glu Ile Phe Ser Asn Glu Met 
        115                 120                 125             


Ala Lys Val Asp Asp Ser Phe Phe His Arg Leu Glu Glu Ser Phe Leu 
    130                 135                 140                 


Val Glu Glu Asp Lys Lys His Glu Arg His Pro Ile Phe Gly Asn Ile 
145                 150                 155                 160 


Val Asp Glu Val Ala Tyr His Glu Lys Tyr Pro Thr Ile Tyr His Leu 
                165                 170                 175     


Arg Lys Lys Leu Val Asp Ser Thr Asp Lys Ala Asp Leu Arg Leu Ile 
            180                 185                 190         


Tyr Leu Ala Leu Ala His Met Ile Lys Phe Arg Gly His Phe Leu Ile 
        195                 200                 205             


Glu Gly Asp Leu Asn Pro Asp Asn Ser Asp Val Asp Lys Leu Phe Ile 
    210                 215                 220                 


Gln Leu Val Gln Thr Tyr Asn Gln Leu Phe Glu Glu Asn Pro Ile Asn 
225                 230                 235                 240 


Ala Ser Gly Val Asp Ala Lys Ala Ile Leu Ser Ala Arg Leu Ser Lys 
                245                 250                 255     


Ser Arg Arg Leu Glu Asn Leu Ile Ala Gln Leu Pro Gly Glu Lys Lys 
            260                 265                 270         


Asn Gly Leu Phe Gly Asn Leu Ile Ala Leu Ser Leu Gly Leu Thr Pro 
        275                 280                 285             


Asn Phe Lys Ser Asn Phe Asp Leu Ala Glu Asp Ala Lys Leu Gln Leu 
    290                 295                 300                 


Ser Lys Asp Thr Tyr Asp Asp Asp Leu Asp Asn Leu Leu Ala Gln Ile 
305                 310                 315                 320 


Gly Asp Gln Tyr Ala Asp Leu Phe Leu Ala Ala Lys Asn Leu Ser Asp 
                325                 330                 335     


Ala Ile Leu Leu Ser Asp Ile Leu Arg Val Asn Thr Glu Ile Thr Lys 
            340                 345                 350         


Ala Pro Leu Ser Ala Ser Met Ile Lys Arg Tyr Asp Glu His His Gln 
        355                 360                 365             


Asp Leu Thr Leu Leu Lys Ala Leu Val Arg Gln Gln Leu Pro Glu Lys 
    370                 375                 380                 


Tyr Lys Glu Ile Phe Phe Asp Gln Ser Lys Asn Gly Tyr Ala Gly Tyr 
385                 390                 395                 400 


Ile Asp Gly Gly Ala Ser Gln Glu Glu Phe Tyr Lys Phe Ile Lys Pro 
                405                 410                 415     


Ile Leu Glu Lys Met Asp Gly Thr Glu Glu Leu Leu Val Lys Leu Asn 
            420                 425                 430         


Arg Glu Asp Leu Leu Arg Lys Gln Arg Thr Phe Asp Asn Gly Ser Ile 
        435                 440                 445             


Pro His Gln Ile His Leu Gly Glu Leu His Ala Ile Leu Arg Arg Gln 
    450                 455                 460                 


Glu Asp Phe Tyr Pro Phe Leu Lys Asp Asn Arg Glu Lys Ile Glu Lys 
465                 470                 475                 480 


Ile Leu Thr Phe Arg Ile Pro Tyr Tyr Val Gly Pro Leu Ala Arg Gly 
                485                 490                 495     


Asn Ser Arg Phe Ala Trp Met Thr Arg Lys Ser Glu Glu Thr Ile Thr 
            500                 505                 510         


Pro Trp Asn Phe Glu Glu Val Val Asp Lys Gly Ala Ser Ala Gln Ser 
        515                 520                 525             


Phe Ile Glu Arg Met Thr Asn Phe Asp Lys Asn Leu Pro Asn Glu Lys 
    530                 535                 540                 


Val Leu Pro Lys His Ser Leu Leu Tyr Glu Tyr Phe Thr Val Tyr Asn 
545                 550                 555                 560 


Glu Leu Thr Lys Val Lys Tyr Val Thr Glu Gly Met Arg Lys Pro Ala 
                565                 570                 575     


Phe Leu Ser Gly Glu Gln Lys Lys Ala Ile Val Asp Leu Leu Phe Lys 
            580                 585                 590         


Thr Asn Arg Lys Val Thr Val Lys Gln Leu Lys Glu Asp Tyr Phe Lys 
        595                 600                 605             


Lys Ile Glu Cys Phe Asp Ser Val Glu Ile Ser Gly Val Glu Asp Arg 
    610                 615                 620                 


Phe Asn Ala Ser Leu Gly Thr Tyr His Asp Leu Leu Lys Ile Ile Lys 
625                 630                 635                 640 


Asp Lys Asp Phe Leu Asp Asn Glu Glu Asn Glu Asp Ile Leu Glu Asp 
                645                 650                 655     


Ile Val Leu Thr Leu Thr Leu Phe Glu Asp Arg Glu Met Ile Glu Glu 
            660                 665                 670         


Arg Leu Lys Thr Tyr Ala His Leu Phe Asp Asp Lys Val Met Lys Gln 
        675                 680                 685             


Leu Lys Arg Arg Arg Tyr Thr Gly Trp Gly Arg Leu Ser Arg Lys Leu 
    690                 695                 700                 


Ile Asn Gly Ile Arg Asp Lys Gln Ser Gly Lys Thr Ile Leu Asp Phe 
705                 710                 715                 720 


Leu Lys Ser Asp Gly Phe Ala Asn Arg Asn Phe Met Gln Leu Ile His 
                725                 730                 735     


Asp Asp Ser Leu Thr Phe Lys Glu Asp Ile Gln Lys Ala Gln Val Ser 
            740                 745                 750         


Gly Gln Gly Asp Ser Leu His Glu His Ile Ala Asn Leu Ala Gly Ser 
        755                 760                 765             


Pro Ala Ile Lys Lys Gly Ile Leu Gln Thr Val Lys Val Val Asp Glu 
    770                 775                 780                 


Leu Val Lys Val Met Gly Arg His Lys Pro Glu Asn Ile Val Ile Glu 
785                 790                 795                 800 


Met Ala Arg Glu Asn Gln Thr Thr Gln Lys Gly Gln Lys Asn Ser Arg 
                805                 810                 815     


Glu Arg Met Lys Arg Ile Glu Glu Gly Ile Lys Glu Leu Gly Ser Gln 
            820                 825                 830         


Ile Leu Lys Glu His Pro Val Glu Asn Thr Gln Leu Gln Asn Glu Lys 
        835                 840                 845             


Leu Tyr Leu Tyr Tyr Leu Gln Asn Gly Arg Asp Met Tyr Val Asp Gln 
    850                 855                 860                 


Glu Leu Asp Ile Asn Arg Leu Ser Asp Tyr Asp Val Asp His Ile Val 
865                 870                 875                 880 


Pro Gln Ser Phe Leu Lys Asp Asp Ser Ile Asp Asn Lys Val Leu Thr 
                885                 890                 895     


Arg Ser Asp Lys Asn Arg Gly Lys Ser Asp Asn Val Pro Ser Glu Glu 
            900                 905                 910         


Val Val Lys Lys Met Lys Asn Tyr Trp Arg Gln Leu Leu Asn Ala Lys 
        915                 920                 925             


Leu Ile Thr Gln Arg Lys Phe Asp Asn Leu Thr Lys Ala Glu Arg Gly 
    930                 935                 940                 


Gly Leu Ser Glu Leu Asp Lys Ala Gly Phe Ile Lys Arg Gln Leu Val 
945                 950                 955                 960 


Glu Thr Arg Gln Ile Thr Lys His Val Ala Gln Ile Leu Asp Ser Arg 
                965                 970                 975     


Met Asn Thr Lys Tyr Asp Glu Asn Asp Lys Leu Ile Arg Glu Val Lys 
            980                 985                 990         


Val Ile Thr Leu Lys Ser Lys Leu  Val Ser Asp Phe Arg  Lys Asp Phe 
        995                 1000                 1005             


Gln Phe  Tyr Lys Val Arg Glu  Ile Asn Asn Tyr His  His Ala His 
    1010                 1015                 1020             


Asp Ala  Tyr Leu Asn Ala Val  Val Gly Thr Ala Leu  Ile Lys Lys 
    1025                 1030                 1035             


Tyr Pro  Lys Leu Glu Ser Glu  Phe Val Tyr Gly Asp  Tyr Lys Val 
    1040                 1045                 1050             


Tyr Asp  Val Arg Lys Met Ile  Ala Lys Ser Glu Gln  Glu Ile Gly 
    1055                 1060                 1065             


Lys Ala  Thr Ala Lys Tyr Phe  Phe Tyr Ser Asn Ile  Met Asn Phe 
    1070                 1075                 1080             


Phe Lys  Thr Glu Ile Thr Leu  Ala Asn Gly Glu Ile  Arg Lys Arg 
    1085                 1090                 1095             


Pro Leu  Ile Glu Thr Asn Gly  Glu Thr Gly Glu Ile  Val Trp Asp 
    1100                 1105                 1110             


Lys Gly  Arg Asp Phe Ala Thr  Val Arg Lys Val Leu  Ser Met Pro 
    1115                 1120                 1125             


Gln Val  Asn Ile Val Lys Lys  Thr Glu Val Gln Thr  Gly Gly Phe 
    1130                 1135                 1140             


Ser Lys  Glu Ser Ile Leu Pro  Lys Arg Asn Ser Asp  Lys Leu Ile 
    1145                 1150                 1155             


Ala Arg  Lys Lys Asp Trp Asp  Pro Lys Lys Tyr Gly  Gly Phe Asp 
    1160                 1165                 1170             


Ser Pro  Thr Val Ala Tyr Ser  Val Leu Val Val Ala  Lys Val Glu 
    1175                 1180                 1185             


Lys Gly  Lys Ser Lys Lys Leu  Lys Ser Val Lys Glu  Leu Leu Gly 
    1190                 1195                 1200             


Ile Thr  Ile Met Glu Arg Ser  Ser Phe Glu Lys Asn  Pro Ile Asp 
    1205                 1210                 1215             


Phe Leu  Glu Ala Lys Gly Tyr  Lys Glu Val Lys Lys  Asp Leu Ile 
    1220                 1225                 1230             


Ile Lys  Leu Pro Lys Tyr Ser  Leu Phe Glu Leu Glu  Asn Gly Arg 
    1235                 1240                 1245             


Lys Arg  Met Leu Ala Ser Ala  Gly Glu Leu Gln Lys  Gly Asn Glu 
    1250                 1255                 1260             


Leu Ala  Leu Pro Ser Lys Tyr  Val Asn Phe Leu Tyr  Leu Ala Ser 
    1265                 1270                 1275             


His Tyr  Glu Lys Leu Lys Gly  Ser Pro Glu Asp Asn  Glu Gln Lys 
    1280                 1285                 1290             


Gln Leu  Phe Val Glu Gln His  Lys His Tyr Leu Asp  Glu Ile Ile 
    1295                 1300                 1305             


Glu Gln  Ile Ser Glu Phe Ser  Lys Arg Val Ile Leu  Ala Asp Ala 
    1310                 1315                 1320             


Asn Leu  Asp Lys Val Leu Ser  Ala Tyr Asn Lys His  Arg Asp Lys 
    1325                 1330                 1335             


Pro Ile  Arg Glu Gln Ala Glu  Asn Ile Ile His Leu  Phe Thr Leu 
    1340                 1345                 1350             


Thr Asn  Leu Gly Ala Pro Ala  Ala Phe Lys Tyr Phe  Asp Thr Thr 
    1355                 1360                 1365             


Ile Asp  Arg Lys Arg Tyr Thr  Ser Thr Lys Glu Val  Leu Asp Ala 
    1370                 1375                 1380             


Thr Leu  Ile His Gln Ser Ile  Thr Gly Leu Tyr Glu  Thr Arg Ile 
    1385                 1390                 1395             


Asp Leu  Ser Gln Leu Gly Gly  Asp Ser Pro Lys Lys  Lys Arg Lys 
    1400                 1405                 1410             


Val Glu  Ala Ser Gly Gly Gly  Gly Ser Gly Gly Gly  Gly Ser Gly 
    1415                 1420                 1425             


Gly Gly  Gly Ser Gly Pro Ala  
    1430                 1435 


<210>  26
<211>  1435
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  26

Met Ile Asp Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
1               5                   10                  15      


Gly Ser Met Tyr Pro Tyr Asp Val Pro Asp Tyr Ala Ser Pro Lys Lys 
            20                  25                  30          


Lys Arg Lys Val Glu Ala Ser Asp Lys Lys Tyr Ser Ile Gly Leu Ala 
        35                  40                  45              


Ile Gly Thr Asn Ser Val Gly Trp Ala Val Ile Thr Asp Glu Tyr Lys 
    50                  55                  60                  


Val Pro Ser Lys Lys Phe Lys Val Leu Gly Asn Thr Asp Arg His Ser 
65                  70                  75                  80  


Ile Lys Lys Asn Leu Ile Gly Ala Leu Leu Phe Asp Ser Gly Glu Thr 
                85                  90                  95      


Ala Glu Ala Thr Arg Leu Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg 
            100                 105                 110         


Arg Lys Asn Arg Ile Cys Tyr Leu Gln Glu Ile Phe Ser Asn Glu Met 
        115                 120                 125             


Ala Lys Val Asp Asp Ser Phe Phe His Arg Leu Glu Glu Ser Phe Leu 
    130                 135                 140                 


Val Glu Glu Asp Lys Lys His Glu Arg His Pro Ile Phe Gly Asn Ile 
145                 150                 155                 160 


Val Asp Glu Val Ala Tyr His Glu Lys Tyr Pro Thr Ile Tyr His Leu 
                165                 170                 175     


Arg Lys Lys Leu Val Asp Ser Thr Asp Lys Ala Asp Leu Arg Leu Ile 
            180                 185                 190         


Tyr Leu Ala Leu Ala His Met Ile Lys Phe Arg Gly His Phe Leu Ile 
        195                 200                 205             


Glu Gly Asp Leu Asn Pro Asp Asn Ser Asp Val Asp Lys Leu Phe Ile 
    210                 215                 220                 


Gln Leu Val Gln Thr Tyr Asn Gln Leu Phe Glu Glu Asn Pro Ile Asn 
225                 230                 235                 240 


Ala Ser Gly Val Asp Ala Lys Ala Ile Leu Ser Ala Arg Leu Ser Lys 
                245                 250                 255     


Ser Arg Arg Leu Glu Asn Leu Ile Ala Gln Leu Pro Gly Glu Lys Lys 
            260                 265                 270         


Asn Gly Leu Phe Gly Asn Leu Ile Ala Leu Ser Leu Gly Leu Thr Pro 
        275                 280                 285             


Asn Phe Lys Ser Asn Phe Asp Leu Ala Glu Asp Ala Lys Leu Gln Leu 
    290                 295                 300                 


Ser Lys Asp Thr Tyr Asp Asp Asp Leu Asp Asn Leu Leu Ala Gln Ile 
305                 310                 315                 320 


Gly Asp Gln Tyr Ala Asp Leu Phe Leu Ala Ala Lys Asn Leu Ser Asp 
                325                 330                 335     


Ala Ile Leu Leu Ser Asp Ile Leu Arg Val Asn Thr Glu Ile Thr Lys 
            340                 345                 350         


Ala Pro Leu Ser Ala Ser Met Ile Lys Arg Tyr Asp Glu His His Gln 
        355                 360                 365             


Asp Leu Thr Leu Leu Lys Ala Leu Val Arg Gln Gln Leu Pro Glu Lys 
    370                 375                 380                 


Tyr Lys Glu Ile Phe Phe Asp Gln Ser Lys Asn Gly Tyr Ala Gly Tyr 
385                 390                 395                 400 


Ile Asp Gly Gly Ala Ser Gln Glu Glu Phe Tyr Lys Phe Ile Lys Pro 
                405                 410                 415     


Ile Leu Glu Lys Met Asp Gly Thr Glu Glu Leu Leu Val Lys Leu Asn 
            420                 425                 430         


Arg Glu Asp Leu Leu Arg Lys Gln Arg Thr Phe Asp Asn Gly Ser Ile 
        435                 440                 445             


Pro His Gln Ile His Leu Gly Glu Leu His Ala Ile Leu Arg Arg Gln 
    450                 455                 460                 


Glu Asp Phe Tyr Pro Phe Leu Lys Asp Asn Arg Glu Lys Ile Glu Lys 
465                 470                 475                 480 


Ile Leu Thr Phe Arg Ile Pro Tyr Tyr Val Gly Pro Leu Ala Arg Gly 
                485                 490                 495     


Asn Ser Arg Phe Ala Trp Met Thr Arg Lys Ser Glu Glu Thr Ile Thr 
            500                 505                 510         


Pro Trp Asn Phe Glu Glu Val Val Asp Lys Gly Ala Ser Ala Gln Ser 
        515                 520                 525             


Phe Ile Glu Arg Met Thr Asn Phe Asp Lys Asn Leu Pro Asn Glu Lys 
    530                 535                 540                 


Val Leu Pro Lys His Ser Leu Leu Tyr Glu Tyr Phe Thr Val Tyr Asn 
545                 550                 555                 560 


Glu Leu Thr Lys Val Lys Tyr Val Thr Glu Gly Met Arg Lys Pro Ala 
                565                 570                 575     


Phe Leu Ser Gly Glu Gln Lys Lys Ala Ile Val Asp Leu Leu Phe Lys 
            580                 585                 590         


Thr Asn Arg Lys Val Thr Val Lys Gln Leu Lys Glu Asp Tyr Phe Lys 
        595                 600                 605             


Lys Ile Glu Cys Phe Asp Ser Val Glu Ile Ser Gly Val Glu Asp Arg 
    610                 615                 620                 


Phe Asn Ala Ser Leu Gly Thr Tyr His Asp Leu Leu Lys Ile Ile Lys 
625                 630                 635                 640 


Asp Lys Asp Phe Leu Asp Asn Glu Glu Asn Glu Asp Ile Leu Glu Asp 
                645                 650                 655     


Ile Val Leu Thr Leu Thr Leu Phe Glu Asp Arg Glu Met Ile Glu Glu 
            660                 665                 670         


Arg Leu Lys Thr Tyr Ala His Leu Phe Asp Asp Lys Val Met Lys Gln 
        675                 680                 685             


Leu Lys Arg Arg Arg Tyr Thr Gly Trp Gly Arg Leu Ser Arg Lys Leu 
    690                 695                 700                 


Ile Asn Gly Ile Arg Asp Lys Gln Ser Gly Lys Thr Ile Leu Asp Phe 
705                 710                 715                 720 


Leu Lys Ser Asp Gly Phe Ala Asn Arg Asn Phe Met Gln Leu Ile His 
                725                 730                 735     


Asp Asp Ser Leu Thr Phe Lys Glu Asp Ile Gln Lys Ala Gln Val Ser 
            740                 745                 750         


Gly Gln Gly Asp Ser Leu His Glu His Ile Ala Asn Leu Ala Gly Ser 
        755                 760                 765             


Pro Ala Ile Lys Lys Gly Ile Leu Gln Thr Val Lys Val Val Asp Glu 
    770                 775                 780                 


Leu Val Lys Val Met Gly Arg His Lys Pro Glu Asn Ile Val Ile Glu 
785                 790                 795                 800 


Met Ala Arg Glu Asn Gln Thr Thr Gln Lys Gly Gln Lys Asn Ser Arg 
                805                 810                 815     


Glu Arg Met Lys Arg Ile Glu Glu Gly Ile Lys Glu Leu Gly Ser Gln 
            820                 825                 830         


Ile Leu Lys Glu His Pro Val Glu Asn Thr Gln Leu Gln Asn Glu Lys 
        835                 840                 845             


Leu Tyr Leu Tyr Tyr Leu Gln Asn Gly Arg Asp Met Tyr Val Asp Gln 
    850                 855                 860                 


Glu Leu Asp Ile Asn Arg Leu Ser Asp Tyr Asp Val Asp His Ile Val 
865                 870                 875                 880 


Pro Gln Ser Phe Leu Lys Asp Asp Ser Ile Asp Asn Lys Val Leu Thr 
                885                 890                 895     


Arg Ser Asp Lys Asn Arg Gly Lys Ser Asp Asn Val Pro Ser Glu Glu 
            900                 905                 910         


Val Val Lys Lys Met Lys Asn Tyr Trp Arg Gln Leu Leu Asn Ala Lys 
        915                 920                 925             


Leu Ile Thr Gln Arg Lys Phe Asp Asn Leu Thr Lys Ala Glu Arg Gly 
    930                 935                 940                 


Gly Leu Ser Glu Leu Asp Lys Ala Gly Phe Ile Lys Arg Gln Leu Val 
945                 950                 955                 960 


Glu Thr Arg Gln Ile Thr Lys His Val Ala Gln Ile Leu Asp Ser Arg 
                965                 970                 975     


Met Asn Thr Lys Tyr Asp Glu Asn Asp Lys Leu Ile Arg Glu Val Lys 
            980                 985                 990         


Val Ile Thr Leu Lys Ser Lys Leu  Val Ser Asp Phe Arg  Lys Asp Phe 
        995                 1000                 1005             


Gln Phe  Tyr Lys Val Arg Glu  Ile Asn Asn Tyr His  His Ala His 
    1010                 1015                 1020             


Asp Ala  Tyr Leu Asn Ala Val  Val Gly Thr Ala Leu  Ile Lys Lys 
    1025                 1030                 1035             


Tyr Pro  Lys Leu Glu Ser Glu  Phe Val Tyr Gly Asp  Tyr Lys Val 
    1040                 1045                 1050             


Tyr Asp  Val Arg Lys Met Ile  Ala Lys Ser Glu Gln  Glu Ile Gly 
    1055                 1060                 1065             


Lys Ala  Thr Ala Lys Tyr Phe  Phe Tyr Ser Asn Ile  Met Asn Phe 
    1070                 1075                 1080             


Phe Lys  Thr Glu Ile Thr Leu  Ala Asn Gly Glu Ile  Arg Lys Arg 
    1085                 1090                 1095             


Pro Leu  Ile Glu Thr Asn Gly  Glu Thr Gly Glu Ile  Val Trp Asp 
    1100                 1105                 1110             


Lys Gly  Arg Asp Phe Ala Thr  Val Arg Lys Val Leu  Ser Met Pro 
    1115                 1120                 1125             


Gln Val  Asn Ile Val Lys Lys  Thr Glu Val Gln Thr  Gly Gly Phe 
    1130                 1135                 1140             


Ser Lys  Glu Ser Ile Leu Pro  Lys Arg Asn Ser Asp  Lys Leu Ile 
    1145                 1150                 1155             


Ala Arg  Lys Lys Asp Trp Asp  Pro Lys Lys Tyr Gly  Gly Phe Asp 
    1160                 1165                 1170             


Ser Pro  Thr Val Ala Tyr Ser  Val Leu Val Val Ala  Lys Val Glu 
    1175                 1180                 1185             


Lys Gly  Lys Ser Lys Lys Leu  Lys Ser Val Lys Glu  Leu Leu Gly 
    1190                 1195                 1200             


Ile Thr  Ile Met Glu Arg Ser  Ser Phe Glu Lys Asn  Pro Ile Asp 
    1205                 1210                 1215             


Phe Leu  Glu Ala Lys Gly Tyr  Lys Glu Val Lys Lys  Asp Leu Ile 
    1220                 1225                 1230             


Ile Lys  Leu Pro Lys Tyr Ser  Leu Phe Glu Leu Glu  Asn Gly Arg 
    1235                 1240                 1245             


Lys Arg  Met Leu Ala Ser Ala  Gly Glu Leu Gln Lys  Gly Asn Glu 
    1250                 1255                 1260             


Leu Ala  Leu Pro Ser Lys Tyr  Val Asn Phe Leu Tyr  Leu Ala Ser 
    1265                 1270                 1275             


His Tyr  Glu Lys Leu Lys Gly  Ser Pro Glu Asp Asn  Glu Gln Lys 
    1280                 1285                 1290             


Gln Leu  Phe Val Glu Gln His  Lys His Tyr Leu Asp  Glu Ile Ile 
    1295                 1300                 1305             


Glu Gln  Ile Ser Glu Phe Ser  Lys Arg Val Ile Leu  Ala Asp Ala 
    1310                 1315                 1320             


Asn Leu  Asp Lys Val Leu Ser  Ala Tyr Asn Lys His  Arg Asp Lys 
    1325                 1330                 1335             


Pro Ile  Arg Glu Gln Ala Glu  Asn Ile Ile His Leu  Phe Thr Leu 
    1340                 1345                 1350             


Thr Asn  Leu Gly Ala Pro Ala  Ala Phe Lys Tyr Phe  Asp Thr Thr 
    1355                 1360                 1365             


Ile Asp  Arg Lys Arg Tyr Thr  Ser Thr Lys Glu Val  Leu Asp Ala 
    1370                 1375                 1380             


Thr Leu  Ile His Gln Ser Ile  Thr Gly Leu Tyr Glu  Thr Arg Ile 
    1385                 1390                 1395             


Asp Leu  Ser Gln Leu Gly Gly  Asp Ser Pro Lys Lys  Lys Arg Lys 
    1400                 1405                 1410             


Val Glu  Ala Ser Gly Gly Gly  Gly Ser Gly Gly Gly  Gly Ser Gly 
    1415                 1420                 1425             


Gly Gly  Gly Ser Gly Pro Ala  
    1430                 1435 


<210>  27
<211>  351
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  27

Ser Arg Gly Arg Ser Arg Leu Leu Glu Asp Phe Arg Asn Asn Arg Tyr 
1               5                   10                  15      


Pro Asn Leu Gln Leu Arg Glu Ile Ala Gly His Ile Met Glu Phe Ser 
            20                  25                  30          


Gln Asp Gln His Gly Ser Arg Phe Ile Gln Leu Lys Leu Glu Arg Ala 
        35                  40                  45              


Thr Pro Ala Glu Arg Gln Leu Val Phe Asn Glu Ile Leu Gln Ala Ala 
    50                  55                  60                  


Tyr Gln Leu Met Val Asp Val Phe Gly Asn Tyr Val Ile Gln Lys Phe 
65                  70                  75                  80  


Phe Glu Phe Gly Ser Leu Glu Gln Lys Leu Ala Leu Ala Glu Arg Ile 
                85                  90                  95      


Arg Gly His Val Leu Ser Leu Ala Leu Gln Met Tyr Gly Ser Arg Val 
            100                 105                 110         


Ile Glu Lys Ala Leu Glu Phe Ile Pro Ser Asp Gln Gln Asn Glu Met 
        115                 120                 125             


Val Arg Glu Leu Asp Gly His Val Leu Lys Cys Val Lys Asp Gln Asn 
    130                 135                 140                 


Gly Asn His Val Val Gln Lys Cys Ile Glu Cys Val Gln Pro Gln Ser 
145                 150                 155                 160 


Leu Gln Phe Ile Ile Asp Ala Phe Lys Gly Gln Val Phe Ala Leu Ser 
                165                 170                 175     


Thr His Pro Tyr Gly Cys Arg Val Ile Gln Arg Ile Leu Glu His Cys 
            180                 185                 190         


Leu Pro Asp Gln Thr Leu Pro Ile Leu Glu Glu Leu His Gln His Thr 
        195                 200                 205             


Glu Gln Leu Val Gln Asp Gln Tyr Gly Asn Tyr Val Ile Gln His Val 
    210                 215                 220                 


Leu Glu His Gly Arg Pro Glu Asp Lys Ser Lys Ile Val Ala Glu Ile 
225                 230                 235                 240 


Arg Gly Asn Val Leu Val Leu Ser Gln His Lys Phe Ala Ser Asn Val 
                245                 250                 255     


Val Glu Lys Cys Val Thr His Ala Ser Arg Thr Glu Arg Ala Val Leu 
            260                 265                 270         


Ile Asp Glu Val Cys Thr Met Asn Asp Gly Pro His Ser Ala Leu Tyr 
        275                 280                 285             


Thr Met Met Lys Asp Gln Tyr Ala Asn Tyr Val Val Gln Lys Met Ile 
    290                 295                 300                 


Asp Val Ala Glu Pro Gly Gln Arg Lys Ile Val Met His Lys Ile Arg 
305                 310                 315                 320 


Pro His Ile Ala Thr Leu Arg Lys Tyr Thr Tyr Gly Lys His Ile Leu 
                325                 330                 335     


Ala Lys Leu Glu Lys Tyr Tyr Met Lys Asn Gly Val Asp Leu Gly 
            340                 345                 350     


<210>  28
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  28

Asp Pro Lys Lys Lys Arg Lys Val 
1               5               


<210>  29
<211>  24
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  29

Asp Pro Lys Lys Lys Arg Lys Val Asp Pro Lys Lys Lys Arg Lys Val 
1               5                   10                  15      


Asp Pro Lys Lys Lys Arg Lys Val 
            20                  


<210>  30
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  30

Gly Gly Gly Gly Ser 
1               5   


<210>  31
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  31

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
1               5                   10                  15  


<210>  32
<211>  23
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  32

Met Asp Tyr Lys Asp His Asp Gly Asp Tyr Lys Asp His Asp Ile Asp 
1               5                   10                  15      


Tyr Lys Asp Asp Asp Asp Lys 
            20              


<210>  33
<211>  7301
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide

<400>  33
tcaatattgg ccattagcca tattattcat tggttatata gcataaatca atattggcta       60

ttggccattg catacgttgt atctatatca taatatgtac atttatattg gctcatgtcc      120

aatatgaccg ccatgttggc attgattatt gactagttat taatagtaat caattacggg      180

gtcattagtt catagcccat atatggagtt ccgcgttaca taacttacgg taaatggccc      240

gcctggctga ccgcccaacg acccccgccc attgacgtca ataatgacgt atgttcccat      300

agtaacgcca atagggactt tccattgacg tcaatgggtg gagtatttac ggtaaactgc      360

ccacttggca gtacatcaag tgtatcatat gccaagtccg ccccctattg acgtcaatga      420

cggtaaatgg cccgcctggc attatgccca gtacatgacc ttacgggact ttcctacttg      480

gcagtacatc tacgtattag tcatcgctat taccatggtg atgcggtttt ggcagtacac      540

caatgggcgt ggatagcggt ttgactcacg gggatttcca agtctccacc ccattgacgt      600

caatgggagt ttgttttggc accaaaatca acgggacttt ccaaaatgtc gtaataaccc      660

cgccccgttg acgcaaatgg gcggtaggcg tgtacggtgg gaggtctata taagcagagg      720

tcgtttagtg aaccgtcaga tcactagtag ctttattgcg gtagtttatc acagttaaat      780

tgctaacgca gtcagtgctc gactgatcac aggtaagtat caaggttaca agacaggttt      840

aaggaggcca atagaaactg ggcttgtcga gacagagaag attcttgcgt ttctgatagg      900

cacctattgg tcttactgac atccactttg cctttctctc cacagggaaa aaacaattga      960

caagtttgta caaaaaagca ggctccgaat tcaccggtgc cgccaccatg atcgatggtg     1020

gcggtggtag cgggggaggc ggctccgggg gcggaggcag tatgtaccca tacgatgttc     1080

cagattacgc ttcgccgaag aaaaagcgca aggtcgaagc gtccgacaag aagtacagca     1140

tcggcctgga catcggcacc aactctgtgg gctgggccgt gatcaccgac gagtacaagg     1200

tgcccagcaa gaaattcaag gtgctgggca acaccgaccg gcacagcatc aagaagaacc     1260

tgatcggagc cctgctgttc gacagcggcg aaacagccga ggccacccgg ctgaagagaa     1320

ccgccagaag aagatacacc agacggaaga accggatctg ctatctgcaa gagatcttca     1380

gcaacgagat ggccaaggtg gacgacagct tcttccacag actggaagag tccttcctgg     1440

tggaagagga taagaagcac gagcggcacc ccatcttcgg caacatcgtg gacgaggtgg     1500

cctaccacga gaagtacccc accatctacc acctgagaaa gaaactggtg gacagcaccg     1560

acaaggccga cctgcggctg atctatctgg ccctggccca catgatcaag ttccggggcc     1620

acttcctgat cgagggcgac ctgaaccccg acaacagcga cgtggacaag ctgttcatcc     1680

agctggtgca gacctacaac cagctgttcg aggaaaaccc catcaacgcc agcggcgtgg     1740

acgccaaggc catcctgtct gccagactga gcaagagcag acggctggaa aatctgatcg     1800

cccagctgcc cggcgagaag aagaatggcc tgttcggcaa cctgattgcc ctgagcctgg     1860

gcctgacccc caacttcaag agcaacttcg acctggccga ggatgccaaa ctgcagctga     1920

gcaaggacac ctacgacgac gacctggaca acctgctggc ccagatcggc gaccagtacg     1980

ccgacctgtt tctggccgcc aagaacctgt ccgacgccat cctgctgagc gacatcctga     2040

gagtgaacac cgagatcacc aaggcccccc tgagcgcctc tatgatcaag agatacgacg     2100

agcaccacca ggacctgacc ctgctgaaag ctctcgtgcg gcagcagctg cctgagaagt     2160

acaaagagat tttcttcgac cagagcaaga acggctacgc cggctacatt gacggcggag     2220

ccagccagga agagttctac aagttcatca agcccatcct ggaaaagatg gacggcaccg     2280

aggaactgct cgtgaagctg aacagagagg acctgctgcg gaagcagcgg accttcgaca     2340

acggcagcat cccccaccag atccacctgg gagagctgca cgccattctg cggcggcagg     2400

aagattttta cccattcctg aaggacaacc gggaaaagat cgagaagatc ctgaccttcc     2460

gcatccccta ctacgtgggc cctctggcca ggggaaacag cagattcgcc tggatgacca     2520

gaaagagcga ggaaaccatc accccctgga acttcgagga agtggtggac aagggcgctt     2580

ccgcccagag cttcatcgag cggatgacca acttcgataa gaacctgccc aacgagaagg     2640

tgctgcccaa gcacagcctg ctgtacgagt acttcaccgt gtataacgag ctgaccaaag     2700

tgaaatacgt gaccgaggga atgagaaagc ccgccttcct gagcggcgag cagaaaaagg     2760

ccatcgtgga cctgctgttc aagaccaacc ggaaagtgac cgtgaagcag ctgaaagagg     2820

actacttcaa gaaaatcgag tgcttcgact ccgtggaaat ctccggcgtg gaagatcggt     2880

tcaacgcctc cctgggcaca taccacgatc tgctgaaaat tatcaaggac aaggacttcc     2940

tggacaatga ggaaaacgag gacattctgg aagatatcgt gctgaccctg acactgtttg     3000

aggacagaga gatgatcgag gaacggctga aaacctatgc ccacctgttc gacgacaaag     3060

tgatgaagca gctgaagcgg cggagataca ccggctgggg caggctgagc cggaagctga     3120

tcaacggcat ccgggacaag cagtccggca agacaatcct ggatttcctg aagtccgacg     3180

gcttcgccaa cagaaacttc atgcagctga tccacgacga cagcctgacc tttaaagagg     3240

acatccagaa agcccaggtg tccggccagg gcgatagcct gcacgagcac attgccaatc     3300

tggccggcag ccccgccatt aagaagggca tcctgcagac agtgaaggtg gtggacgagc     3360

tcgtgaaagt gatgggccgg cacaagcccg agaacatcgt gatcgaaatg gccagagaga     3420

accagaccac ccagaaggga cagaagaaca gccgcgagag aatgaagcgg atcgaagagg     3480

gcatcaaaga gctgggcagc cagatcctga aagaacaccc cgtggaaaac acccagctgc     3540

agaacgagaa gctgtacctg tactacctgc agaatgggcg ggatatgtac gtggaccagg     3600

aactggacat caaccggctg tccgactacg atgtggacca tatcgtgcct cagagctttc     3660

tgaaggacga ctccatcgac aacaaggtgc tgaccagaag cgacaagaac cggggcaaga     3720

gcgacaacgt gccctccgaa gaggtcgtga agaagatgaa gaactactgg cggcagctgc     3780

tgaacgccaa gctgattacc cagagaaagt tcgacaatct gaccaaggcc gagagaggcg     3840

gcctgagcga actggataag gccggcttca tcaagagaca gctggtggaa acccggcaga     3900

tcacaaagca cgtggcacag atcctggact cccggatgaa cactaagtac gacgagaatg     3960

acaagctgat ccgggaagtg aaagtgatca ccctgaagtc caagctggtg tccgatttcc     4020

ggaaggattt ccagttttac aaagtgcgcg agatcaacaa ctaccaccac gcccacgacg     4080

cctacctgaa cgccgtcgtg ggaaccgccc tgatcaaaaa gtaccctaag ctggaaagcg     4140

agttcgtgta cggcgactac aaggtgtacg acgtgcggaa gatgatcgcc aagagcgagc     4200

aggaaatcgg caaggctacc gccaagtact tcttctacag caacatcatg aactttttca     4260

agaccgagat taccctggcc aacggcgaga tccggaagcg gcctctgatc gagacaaacg     4320

gcgaaaccgg ggagatcgtg tgggataagg gccgggattt tgccaccgtg cggaaagtgc     4380

tgagcatgcc ccaagtgaat atcgtgaaaa agaccgaggt gcagacaggc ggcttcagca     4440

aagagtctat cctgcccaag aggaacagcg ataagctgat cgccagaaag aaggactggg     4500

accctaagaa gtacggcggc ttcgacagcc ccaccgtggc ctattctgtg ctggtggtgg     4560

ccaaagtgga aaagggcaag tccaagaaac tgaagagtgt gaaagagctg ctggggatca     4620

ccatcatgga aagaagcagc ttcgagaaga atcccatcga ctttctggaa gccaagggct     4680

acaaagaagt gaaaaaggac ctgatcatca agctgcctaa gtactccctg ttcgagctgg     4740

aaaacggccg gaagagaatg ctggcctctg ccggcgaact gcagaaggga aacgaactgg     4800

ccctgccctc caaatatgtg aacttcctgt acctggccag ccactatgag aagctgaagg     4860

gctcccccga ggataatgag cagaaacagc tgtttgtgga acagcacaag cactacctgg     4920

acgagatcat cgagcagatc agcgagttct ccaagagagt gatcctggcc gacgctaatc     4980

tggacaaagt gctgtccgcc tacaacaagc accgggataa gcccatcaga gagcaggccg     5040

agaatatcat ccacctgttt accctgacca atctgggagc ccctgccgcc ttcaagtact     5100

ttgacaccac catcgaccgg aagaggtaca ccagcaccaa agaggtgctg gacgccaccc     5160

tgatccacca gagcatcacc ggcctgtacg agacacggat cgacctgtct cagctgggag     5220

gcgacagccc caagaagaag agaaaggtgg aggccagcgg aggcggcggt agcggaggag     5280

gcgggtccgg cggcggcggt agtgggccgg cctgattaat taagaattcg acccagcttt     5340

cttgtacaaa gtggttgata tccagcacag tggcggccgc tcgagtctag agggcccgcg     5400

gttcgaaggt aagcctatcc ctaaccctct cctcggtctc gattctacgc gtaccggtta     5460

gcaattgttt tttcgatgag tttggacaaa ccacaactag aatgcagtga aaaaaatgct     5520

ttatttgtga aatttgtgat gctattgctt tatttgtaac cattataagc tgcaataaac     5580

aagttaacaa caacaattgc attcatttta tgtttcaggt tcagggggag gtgtgggagg     5640

ttttttaaag caagtaaaac ctctacaaat gtggtactta agagggggag accaaagggc     5700

gagacgttaa ggcctcacgt gacatgtgag caaaaggcca gcaaaaggcc aggaaccgta     5760

aaaaggccgc gttgctggcg tttttccata ggctccgccc ccctgacgag catcacaaaa     5820

atcgacgctc aagtcagagg tggcgaaacc cgacaggact ataaagatac caggcgtttc     5880

cccctggaag ctccctcgtg cgctctcctg ttccgaccct gccgcttacc ggatacctgt     5940

ccgcctttct cccttcggga agcgtggcgc tttctcatag ctcacgctgt aggtatctca     6000

gttcggtgta ggtcgttcgc tccaagctgg gctgtgtgca cgaacccccc gttcagcccg     6060

accgctgcgc cttatccggt aactatcgtc ttgagtccaa cccggtaaga cacgacttat     6120

cgccactggc agcagccact ggtaacagga ttagcagagc gaggtatgta ggcggtgcta     6180

cagagttctt gaagtggtgg cctaactacg gctacactag aaggacagta tttggtatct     6240

gcgctctgct gaagccagtt accttcggaa aaagagttgg tagctcttga tccggcaaac     6300

aaaccacgct ggtagcggtg gtttttttgt ttgcaagcag cagattacgc gcagaaaaaa     6360

aggatctcaa gaagatcctt tgatcttttc tacggggtct gacgctcagt ggaacgaaaa     6420

ctcacgttaa gggattttgg tcatgccgtc tcagaagaac tcgtcaagaa ggcgatagaa     6480

ggcgatgcgc tgcgaatcgg gagcggcgat accgtaaagc acgaggaagc ggtcagccca     6540

ttcgccgcca agctcttcag caatatcacg ggtagccaac gctatgtcct gatagcggtc     6600

cgccacaccc agccggccac agtcgatgaa tccagaaaag cggccatttt ccaccatgat     6660

attcggcaag caggcatcgc catgggtcac gacgagatcc tcgccgtcgg gcatgctcgc     6720

cttgagcctg gcgaacagtt cggctggcgc gagcccctga tgctcttcgt ccagatcatc     6780

ctgatcgaca agaccggctt ccatccgagt acgtgctcgc tcgatgcgat gtttcgcttg     6840

gtggtcgaat gggcaggtag ccggatcaag cgtatgcagc cgccgcattg catcagccat     6900

gatggatact ttctcggcag gagcaaggtg agatgacagg agatcctgcc ccggcacttc     6960

gcccaatagc agccagtccc ttcccgcttc agtgacaacg tcgagcacag ctgcgcaagg     7020

aacgcccgtc gtggccagcc acgatagccg cgctgcctcg tcttgcagtt cattcagggc     7080

accggacagg tcggtcttga caaaaagaac cgggcgcccc tgcgctgaca gccggaacac     7140

ggcggcatca gagcagccga ttgtctgttg tgcccagtca tagccgaata gcctctccac     7200

ccaagcggcc ggagaacctg cgtgcaatcc atcttgttca atcataatat tattgaagca     7260

tttatcaggg ttcgtctcgt cccggtctcc tcccatgcat g                         7301


<210>  34
<211>  7301
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide

<400>  34
tcaatattgg ccattagcca tattattcat tggttatata gcataaatca atattggcta       60

ttggccattg catacgttgt atctatatca taatatgtac atttatattg gctcatgtcc      120

aatatgaccg ccatgttggc attgattatt gactagttat taatagtaat caattacggg      180

gtcattagtt catagcccat atatggagtt ccgcgttaca taacttacgg taaatggccc      240

gcctggctga ccgcccaacg acccccgccc attgacgtca ataatgacgt atgttcccat      300

agtaacgcca atagggactt tccattgacg tcaatgggtg gagtatttac ggtaaactgc      360

ccacttggca gtacatcaag tgtatcatat gccaagtccg ccccctattg acgtcaatga      420

cggtaaatgg cccgcctggc attatgccca gtacatgacc ttacgggact ttcctacttg      480

gcagtacatc tacgtattag tcatcgctat taccatggtg atgcggtttt ggcagtacac      540

caatgggcgt ggatagcggt ttgactcacg gggatttcca agtctccacc ccattgacgt      600

caatgggagt ttgttttggc accaaaatca acgggacttt ccaaaatgtc gtaataaccc      660

cgccccgttg acgcaaatgg gcggtaggcg tgtacggtgg gaggtctata taagcagagg      720

tcgtttagtg aaccgtcaga tcactagtag ctttattgcg gtagtttatc acagttaaat      780

tgctaacgca gtcagtgctc gactgatcac aggtaagtat caaggttaca agacaggttt      840

aaggaggcca atagaaactg ggcttgtcga gacagagaag attcttgcgt ttctgatagg      900

cacctattgg tcttactgac atccactttg cctttctctc cacagggaaa aaacaattga      960

caagtttgta caaaaaagca ggctccgaat tcaccggtgc cgccaccatg atcgatggtg     1020

gcggtggtag cgggggaggc ggctccgggg gcggaggcag tatgtaccca tacgatgttc     1080

cagattacgc ttcgccgaag aaaaagcgca aggtcgaagc gtccgacaag aagtacagca     1140

tcggcctggc catcggcacc aactctgtgg gctgggccgt gatcaccgac gagtacaagg     1200

tgcccagcaa gaaattcaag gtgctgggca acaccgaccg gcacagcatc aagaagaacc     1260

tgatcggagc cctgctgttc gacagcggcg aaacagccga ggccacccgg ctgaagagaa     1320

ccgccagaag aagatacacc agacggaaga accggatctg ctatctgcaa gagatcttca     1380

gcaacgagat ggccaaggtg gacgacagct tcttccacag actggaagag tccttcctgg     1440

tggaagagga taagaagcac gagcggcacc ccatcttcgg caacatcgtg gacgaggtgg     1500

cctaccacga gaagtacccc accatctacc acctgagaaa gaaactggtg gacagcaccg     1560

acaaggccga cctgcggctg atctatctgg ccctggccca catgatcaag ttccggggcc     1620

acttcctgat cgagggcgac ctgaaccccg acaacagcga cgtggacaag ctgttcatcc     1680

agctggtgca gacctacaac cagctgttcg aggaaaaccc catcaacgcc agcggcgtgg     1740

acgccaaggc catcctgtct gccagactga gcaagagcag acggctggaa aatctgatcg     1800

cccagctgcc cggcgagaag aagaatggcc tgttcggcaa cctgattgcc ctgagcctgg     1860

gcctgacccc caacttcaag agcaacttcg acctggccga ggatgccaaa ctgcagctga     1920

gcaaggacac ctacgacgac gacctggaca acctgctggc ccagatcggc gaccagtacg     1980

ccgacctgtt tctggccgcc aagaacctgt ccgacgccat cctgctgagc gacatcctga     2040

gagtgaacac cgagatcacc aaggcccccc tgagcgcctc tatgatcaag agatacgacg     2100

agcaccacca ggacctgacc ctgctgaaag ctctcgtgcg gcagcagctg cctgagaagt     2160

acaaagagat tttcttcgac cagagcaaga acggctacgc cggctacatt gacggcggag     2220

ccagccagga agagttctac aagttcatca agcccatcct ggaaaagatg gacggcaccg     2280

aggaactgct cgtgaagctg aacagagagg acctgctgcg gaagcagcgg accttcgaca     2340

acggcagcat cccccaccag atccacctgg gagagctgca cgccattctg cggcggcagg     2400

aagattttta cccattcctg aaggacaacc gggaaaagat cgagaagatc ctgaccttcc     2460

gcatccccta ctacgtgggc cctctggcca ggggaaacag cagattcgcc tggatgacca     2520

gaaagagcga ggaaaccatc accccctgga acttcgagga agtggtggac aagggcgctt     2580

ccgcccagag cttcatcgag cggatgacca acttcgataa gaacctgccc aacgagaagg     2640

tgctgcccaa gcacagcctg ctgtacgagt acttcaccgt gtataacgag ctgaccaaag     2700

tgaaatacgt gaccgaggga atgagaaagc ccgccttcct gagcggcgag cagaaaaagg     2760

ccatcgtgga cctgctgttc aagaccaacc ggaaagtgac cgtgaagcag ctgaaagagg     2820

actacttcaa gaaaatcgag tgcttcgact ccgtggaaat ctccggcgtg gaagatcggt     2880

tcaacgcctc cctgggcaca taccacgatc tgctgaaaat tatcaaggac aaggacttcc     2940

tggacaatga ggaaaacgag gacattctgg aagatatcgt gctgaccctg acactgtttg     3000

aggacagaga gatgatcgag gaacggctga aaacctatgc ccacctgttc gacgacaaag     3060

tgatgaagca gctgaagcgg cggagataca ccggctgggg caggctgagc cggaagctga     3120

tcaacggcat ccgggacaag cagtccggca agacaatcct ggatttcctg aagtccgacg     3180

gcttcgccaa cagaaacttc atgcagctga tccacgacga cagcctgacc tttaaagagg     3240

acatccagaa agcccaggtg tccggccagg gcgatagcct gcacgagcac attgccaatc     3300

tggccggcag ccccgccatt aagaagggca tcctgcagac agtgaaggtg gtggacgagc     3360

tcgtgaaagt gatgggccgg cacaagcccg agaacatcgt gatcgaaatg gccagagaga     3420

accagaccac ccagaaggga cagaagaaca gccgcgagag aatgaagcgg atcgaagagg     3480

gcatcaaaga gctgggcagc cagatcctga aagaacaccc cgtggaaaac acccagctgc     3540

agaacgagaa gctgtacctg tactacctgc agaatgggcg ggatatgtac gtggaccagg     3600

aactggacat caaccggctg tccgactacg atgtggacca tatcgtgcct cagagctttc     3660

tgaaggacga ctccatcgac aacaaggtgc tgaccagaag cgacaagaac cggggcaaga     3720

gcgacaacgt gccctccgaa gaggtcgtga agaagatgaa gaactactgg cggcagctgc     3780

tgaacgccaa gctgattacc cagagaaagt tcgacaatct gaccaaggcc gagagaggcg     3840

gcctgagcga actggataag gccggcttca tcaagagaca gctggtggaa acccggcaga     3900

tcacaaagca cgtggcacag atcctggact cccggatgaa cactaagtac gacgagaatg     3960

acaagctgat ccgggaagtg aaagtgatca ccctgaagtc caagctggtg tccgatttcc     4020

ggaaggattt ccagttttac aaagtgcgcg agatcaacaa ctaccaccac gcccacgacg     4080

cctacctgaa cgccgtcgtg ggaaccgccc tgatcaaaaa gtaccctaag ctggaaagcg     4140

agttcgtgta cggcgactac aaggtgtacg acgtgcggaa gatgatcgcc aagagcgagc     4200

aggaaatcgg caaggctacc gccaagtact tcttctacag caacatcatg aactttttca     4260

agaccgagat taccctggcc aacggcgaga tccggaagcg gcctctgatc gagacaaacg     4320

gcgaaaccgg ggagatcgtg tgggataagg gccgggattt tgccaccgtg cggaaagtgc     4380

tgagcatgcc ccaagtgaat atcgtgaaaa agaccgaggt gcagacaggc ggcttcagca     4440

aagagtctat cctgcccaag aggaacagcg ataagctgat cgccagaaag aaggactggg     4500

accctaagaa gtacggcggc ttcgacagcc ccaccgtggc ctattctgtg ctggtggtgg     4560

ccaaagtgga aaagggcaag tccaagaaac tgaagagtgt gaaagagctg ctggggatca     4620

ccatcatgga aagaagcagc ttcgagaaga atcccatcga ctttctggaa gccaagggct     4680

acaaagaagt gaaaaaggac ctgatcatca agctgcctaa gtactccctg ttcgagctgg     4740

aaaacggccg gaagagaatg ctggcctctg ccggcgaact gcagaaggga aacgaactgg     4800

ccctgccctc caaatatgtg aacttcctgt acctggccag ccactatgag aagctgaagg     4860

gctcccccga ggataatgag cagaaacagc tgtttgtgga acagcacaag cactacctgg     4920

acgagatcat cgagcagatc agcgagttct ccaagagagt gatcctggcc gacgctaatc     4980

tggacaaagt gctgtccgcc tacaacaagc accgggataa gcccatcaga gagcaggccg     5040

agaatatcat ccacctgttt accctgacca atctgggagc ccctgccgcc ttcaagtact     5100

ttgacaccac catcgaccgg aagaggtaca ccagcaccaa agaggtgctg gacgccaccc     5160

tgatccacca gagcatcacc ggcctgtacg agacacggat cgacctgtct cagctgggag     5220

gcgacagccc caagaagaag agaaaggtgg aggccagcgg aggcggcggt agcggaggag     5280

gcgggtccgg cggcggcggt agtgggccgg cctgattaat taagaattcg acccagcttt     5340

cttgtacaaa gtggttgata tccagcacag tggcggccgc tcgagtctag agggcccgcg     5400

gttcgaaggt aagcctatcc ctaaccctct cctcggtctc gattctacgc gtaccggtta     5460

gcaattgttt tttcgatgag tttggacaaa ccacaactag aatgcagtga aaaaaatgct     5520

ttatttgtga aatttgtgat gctattgctt tatttgtaac cattataagc tgcaataaac     5580

aagttaacaa caacaattgc attcatttta tgtttcaggt tcagggggag gtgtgggagg     5640

ttttttaaag caagtaaaac ctctacaaat gtggtactta agagggggag accaaagggc     5700

gagacgttaa ggcctcacgt gacatgtgag caaaaggcca gcaaaaggcc aggaaccgta     5760

aaaaggccgc gttgctggcg tttttccata ggctccgccc ccctgacgag catcacaaaa     5820

atcgacgctc aagtcagagg tggcgaaacc cgacaggact ataaagatac caggcgtttc     5880

cccctggaag ctccctcgtg cgctctcctg ttccgaccct gccgcttacc ggatacctgt     5940

ccgcctttct cccttcggga agcgtggcgc tttctcatag ctcacgctgt aggtatctca     6000

gttcggtgta ggtcgttcgc tccaagctgg gctgtgtgca cgaacccccc gttcagcccg     6060

accgctgcgc cttatccggt aactatcgtc ttgagtccaa cccggtaaga cacgacttat     6120

cgccactggc agcagccact ggtaacagga ttagcagagc gaggtatgta ggcggtgcta     6180

cagagttctt gaagtggtgg cctaactacg gctacactag aaggacagta tttggtatct     6240

gcgctctgct gaagccagtt accttcggaa aaagagttgg tagctcttga tccggcaaac     6300

aaaccacgct ggtagcggtg gtttttttgt ttgcaagcag cagattacgc gcagaaaaaa     6360

aggatctcaa gaagatcctt tgatcttttc tacggggtct gacgctcagt ggaacgaaaa     6420

ctcacgttaa gggattttgg tcatgccgtc tcagaagaac tcgtcaagaa ggcgatagaa     6480

ggcgatgcgc tgcgaatcgg gagcggcgat accgtaaagc acgaggaagc ggtcagccca     6540

ttcgccgcca agctcttcag caatatcacg ggtagccaac gctatgtcct gatagcggtc     6600

cgccacaccc agccggccac agtcgatgaa tccagaaaag cggccatttt ccaccatgat     6660

attcggcaag caggcatcgc catgggtcac gacgagatcc tcgccgtcgg gcatgctcgc     6720

cttgagcctg gcgaacagtt cggctggcgc gagcccctga tgctcttcgt ccagatcatc     6780

ctgatcgaca agaccggctt ccatccgagt acgtgctcgc tcgatgcgat gtttcgcttg     6840

gtggtcgaat gggcaggtag ccggatcaag cgtatgcagc cgccgcattg catcagccat     6900

gatggatact ttctcggcag gagcaaggtg agatgacagg agatcctgcc ccggcacttc     6960

gcccaatagc agccagtccc ttcccgcttc agtgacaacg tcgagcacag ctgcgcaagg     7020

aacgcccgtc gtggccagcc acgatagccg cgctgcctcg tcttgcagtt cattcagggc     7080

accggacagg tcggtcttga caaaaagaac cgggcgcccc tgcgctgaca gccggaacac     7140

ggcggcatca gagcagccga ttgtctgttg tgcccagtca tagccgaata gcctctccac     7200

ccaagcggcc ggagaacctg cgtgcaatcc atcttgttca atcataatat tattgaagca     7260

tttatcaggg ttcgtctcgt cccggtctcc tcccatgcat g                         7301


<210>  35
<211>  12899
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide

<400>  35
tcaatattgg ccattagcca tattattcat tggttatata gcataaatca atattggcta       60

ttggccattg catacgttgt atctatatca taatatgtac atttatattg gctcatgtcc      120

aatatgaccg ccatgttggc attgattatt gactagttat taatagtaat caattacggg      180

gtcattagtt catagcccat atatggagtt ccgcgttaca taacttacgg taaatggccc      240

gcctggctga ccgcccaacg acccccgccc attgacgtca ataatgacgt atgttcccat      300

agtaacgcca atagggactt tccattgacg tcaatgggtg gagtatttac ggtaaactgc      360

ccacttggca gtacatcaag tgtatcatat gccaagtccg ccccctattg acgtcaatga      420

cggtaaatgg cccgcctggc attatgccca gtacatgacc ttacgggact ttcctacttg      480

gcagtacatc tacgtattag tcatcgctat taccatggtg atgcggtttt ggcagtacac      540

caatgggcgt ggatagcggt ttgactcacg gggatttcca agtctccacc ccattgacgt      600

caatgggagt ttgttttggc accaaaatca acgggacttt ccaaaatgtc gtaataaccc      660

cgccccgttg acgcaaatgg gcggtaggcg tgtacggtgg gaggtctata taagcagagg      720

tcgtttagtg aaccgtcaga tcactagtag ctttattgcg gtagtttatc acagttaaat      780

tgctaacgca gtcagtgctc gactgatcac aggtaagtat caaggttaca agacaggttt      840

aaggaggcca atagaaactg ggcttgtcga gacagagaag attcttgcgt ttctgatagg      900

cacctattgg tcttactgac atccactttg cctttctctc cacagggaaa aaacaattga      960

caagtttgta caaaaaagca ggctccgaat tcaccggtgc cgccaccatg gggccggcca     1020

tggatttatc tgctcttcgc gttgaagaag tacaaaatgt cattaatgct atgcagaaaa     1080

tcttagagtg tcccatctgt ctggagttga tcaaggaacc tgtctccaca aagtgtgacc     1140

acatattttg caaattttgc atgctgaaac ttctcaacca gaagaaaggg ccttcacagt     1200

gtcctttatg taagaatgat ataaccaaaa ggagcctaca agaaagtacg agatttagtc     1260

aacttgttga agagctattg aaaatcattt gtgcttttca gcttgacaca ggtttggagt     1320

atgcaaacag ctataatttt gcaaaaaagg aaaataactc tcctgaacat ctaaaagatg     1380

aagtttctat catccaaagt atgggctaca gaaaccgtgc caaaagactt ctacagagtg     1440

aacccgaaaa tccttccttg caggaaacca gtctcagtgt ccaactctct aaccttggaa     1500

ctgtgagaac tctgaggaca aagcagcgga tacaacctca aaagacgtct gtctacattg     1560

aattgggatc tgattcttct gaagataccg ttaataaggc aacttattgc agtgtgggag     1620

atcaagaatt gttacaaatc acccctcaag gaaccaggga tgaaatcagt ttggattctg     1680

caaaaaaggc tgcttgtgaa ttttctgaga cggatgtaac aaatactgaa catcatcaac     1740

ccagtaataa tgatttgaac accactgaga agcgtgcagc tgagaggcat ccagaaaagt     1800

atcagggtag ttctgtttca aacttgcatg tggagccatg tggcacaaat actcatgcca     1860

gctcattaca gcatgagaac agcagtttat tactcactaa agacagaatg aatgtagaaa     1920

aggctgaatt ctgtaataaa agcaaacagc ctggcttagc aaggagccaa cataacagat     1980

gggctggaag taaggaaaca tgtaatgata ggcggactcc cagcacagaa aaaaaggtag     2040

atctgaatgc tgatcccctg tgtgagagaa aagaatggaa taagcagaaa ctgccatgct     2100

cagagaatcc tagagatact gaagatgttc cttggataac actaaatagc agcattcaga     2160

aagttaatga gtggttttcc agaagtgatg aactgttagg ttctgatgac tcacatgatg     2220

gggagtctga atcaaatgcc aaagtagctg atgtattgga cgttctaaat gaggtagatg     2280

aatattctgg ttcttcagag aaaatagact tactggccag tgatcctcat gaggctttaa     2340

tatgtaaaag tgaaagagtt cactccaaat cagtagagag taatattgaa gacaaaatat     2400

ttgggaaaac ctatcggaag aaggcaagcc tccccaactt aagccatgta actgaaaatc     2460

taattatagg agcatttgtt actgagccac agataataca agagcgtccc ctcacaaata     2520

aattaaagcg taaaaggaga cctacatcag gccttcatcc tgaggatttt atcaagaaag     2580

cagatttggc agttcaaaag actcctgaaa tgataaatca gggaactaac caaacggagc     2640

agaatggtca agtgatgaat attactaata gtggtcatga gaataaaaca aaaggtgatt     2700

ctattcagaa tgagaaaaat cctaacccaa tagaatcact cgaaaaagaa tctgctttca     2760

aaacgaaagc tgaacctata agcagcagta taagcaatat ggaactcgaa ttaaatatcc     2820

acaattcaaa agcacctaaa aagaataggc tgaggaggaa gtcttctacc aggcatattc     2880

atgcgcttga actagtagtc agtagaaatc taagcccacc taattgtact gaattgcaaa     2940

ttgatagttg ttctagcagt gaagagataa agaaaaaaaa gtacaaccaa atgccagtca     3000

ggcacagcag aaacctacaa ctcatggaag gtaaagaacc tgcaactgga gccaagaaga     3060

gtaacaagcc aaatgaacag acaagtaaaa gacatgacag tgatactttc ccagagctga     3120

agttaacaaa tgcacctggt tcttttacta agtgttcaaa taccagtgaa cttaaagaat     3180

ttgtcaatcc tagccttcca agagaagaaa aagaagagaa actagaaaca gttaaagtgt     3240

ctaataatgc tgaagacccc aaagatctca tgttaagtgg agaaagggtt ttgcaaactg     3300

aaagatctgt agagagtagc agtatttcac tggtacctgg tactgattat ggcactcagg     3360

aaagtatctc gttactggaa gttagcactc tagggaaggc aaaaacagaa ccaaataaat     3420

gtgtgagtca gtgtgcagca tttgaaaacc ccaagggact aattcatggt tgttccaaag     3480

ataatagaaa tgacacagaa ggctttaagt atccattggg acatgaagtt aaccacagtc     3540

gggaaacaag catagaaatg gaagaaagtg aacttgatgc tcagtatttg cagaatacat     3600

tcaaggtttc aaagcgccag tcatttgctc tgttttcaaa tccaggaaat gcagaagagg     3660

aatgtgcaac attctctgcc cactctgggt ccttaaagaa acaaagtcca aaagtcactt     3720

ttgaatgtga acaaaaggaa gaaaatcaag gaaagaatga gtctaatatc aagcctgtac     3780

agacagttaa tatcactgca ggctttcctg tggttggtca gaaagataag ccagttgata     3840

atgccaaatg tagtatcaaa ggaggctcta ggttttgtct atcatctcag ttcagaggca     3900

acgaaactgg actcattact ccaaataaac atggactttt acaaaaccca tatcgtatac     3960

caccactttt tcccatcaag tcatttgtta aaactaaatg taagaaaaat ctgctagagg     4020

aaaactttga ggaacattca atgtcacctg aaagagaaat gggaaatgag aacattccaa     4080

gtacagtgag cacaattagc cgtaataaca ttagagaaaa tgtttttaaa ggagccagct     4140

caagcaatat taatgaagta ggttccagta ctaatgaagt gggctccagt attaatgaaa     4200

taggttccag tgatgaaaac attcaagcag aactaggtag aaacagaggg ccaaaattga     4260

atgctatgct tagattaggg gttttgcaac ctgaggtcta taaacaaagt cttcctggaa     4320

gtaattgtaa gcatcctgaa ataaaaaagc aagaatatga agaagtagtt cagactgtta     4380

atacagattt ctctccatat ctgatttcag ataacttaga acagcctatg ggaagtagtc     4440

atacatctca ggtttgttct gagacacctg atgacctgtt agatgatggt gaaataaagg     4500

aagatactag ttttgctgaa aatgacatta aggaaagttc tgctgttttt agcaaaagcg     4560

tccagagagg agagcttagc aggagtccta gccctttcac ccatacacat ttggctcagg     4620

gttaccgaag aggggccaag aaattagagt cctcagaaga gaacttatct agtgaggatg     4680

aagagcttcc ctgcttccaa cacttgttat ttggtaaagt aaacaatata ccttctcagt     4740

ctactaggca tagcaccgtt gctaccgagt gtctgtctaa gaacacagag gagaatttat     4800

tatcattgaa gaatagctta aatgactgca gtaaccaggt aatattggca aaggcatctc     4860

aggaacatca ccttagtgag gaaacaaaat gttctgctag cttgttttct tcacagtgca     4920

gtgaattgga agacttgact gcaaatacaa acacccagga tcctttcttg attggttctt     4980

ccaaacaaat gaggcatcag tctgaaagcc agggagttgg tctgagtgac aaggaattgg     5040

tttcagatga tgaagaaaga ggaacgggct tggaagaaaa taatcaagaa gagcaaagca     5100

tggattcaaa cttaggtgaa gcagcatctg ggtgtgagag tgaaacaagc gtctctgaag     5160

actgctcagg gctatcctct cagagtgaca ttttaaccac tcagcagagg gataccatgc     5220

aacataacct gataaagctc cagcaggaaa tggctgaact agaagctgtg ttagaacagc     5280

atgggagcca gccttctaac agctacccta gtataatcag tgactcttct gcccttgagg     5340

acctgcgaaa tccagaacaa agcacatcag aaaaagcagt attaacttca cagaaaagta     5400

gtgaataccc tataagccag aatccagaag gcctttctgc tgacaagttt gaggtgtctg     5460

cagatagttc taccagtaaa aataaagaac caggagtgga aaggtcatcc ccttctaaat     5520

gcccatcatt agatgatagg tggtacatgc acagttgctc tgggagtctt cagaatagaa     5580

actacccatc tcaagaggag ctcattaagg ttgttgatgt ggaggagcaa cagctggaag     5640

agtctgggcc acacgatttg acggaaacat cttacttgcc aaggcaagat ctagagggaa     5700

ccccttacct ggaatctgga atcagcctct tctctgatga ccctgaatct gatccttctg     5760

aagacagagc cccagagtca gctcgtgttg gcaacatacc atcttcaacc tctgcattga     5820

aagttcccca attgaaagtt gcagaatctg cccagggtcc agctgctgct catactactg     5880

atactgctgg gtataatgca atggaagaaa gtgtgagcag ggagaagcca gaattgacag     5940

cttcaacaga aagggtcaac aaaagaatgt ccatggtggt gtctggcctg accccagaag     6000

aatttatgct cgtgtacaag tttgccagaa aacaccacat cactttaact aatctaatta     6060

ctgaagagac tactcatgtt gttatgaaaa cagatgctga gtttgtgtgt gaacggacac     6120

tgaaatattt tctaggaatt gcgggaggaa aatgggtagt tagctatttc tgggtgaccc     6180

agtctattaa agaaagaaaa atgctgaatg agcatgattt tgaagtcaga ggagatgtgg     6240

tcaatggaag aaaccaccaa ggtccaaagc gagcaagaga atcccaggac agaaagatct     6300

tcagggggct agaaatctgt tgctatgggc ccttcaccaa catgcccaca gatcaactgg     6360

aatggatggt acagctgtgt ggtgcttctg tggtgaagga gctttcatca ttcacccttg     6420

gcacaggtgt ccacccaatt gtggttgtgc agccagatgc ctggacagag gacaatggct     6480

tccatgcaat tgggcagatg tgtgaggcac ctgtggtgac ccgagagtgg gtgttggaca     6540

gtgtagcact ctaccagtgc caggagctgg acacctacct gataccccag atcccccaca     6600

gccactacat cgatggtggc ggtggtagcg ggggaggcgg ctccgggggc ggaggcagta     6660

tgtacccata cgatgttcca gattacgctt cgccgaagaa aaagcgcaag gtcgaagcgt     6720

ccgacaagaa gtacagcatc ggcctggaca tcggcaccaa ctctgtgggc tgggccgtga     6780

tcaccgacga gtacaaggtg cccagcaaga aattcaaggt gctgggcaac accgaccggc     6840

acagcatcaa gaagaacctg atcggagccc tgctgttcga cagcggcgaa acagccgagg     6900

ccacccggct gaagagaacc gccagaagaa gatacaccag acggaagaac cggatctgct     6960

atctgcaaga gatcttcagc aacgagatgg ccaaggtgga cgacagcttc ttccacagac     7020

tggaagagtc cttcctggtg gaagaggata agaagcacga gcggcacccc atcttcggca     7080

acatcgtgga cgaggtggcc taccacgaga agtaccccac catctaccac ctgagaaaga     7140

aactggtgga cagcaccgac aaggccgacc tgcggctgat ctatctggcc ctggcccaca     7200

tgatcaagtt ccggggccac ttcctgatcg agggcgacct gaaccccgac aacagcgacg     7260

tggacaagct gttcatccag ctggtgcaga cctacaacca gctgttcgag gaaaacccca     7320

tcaacgccag cggcgtggac gccaaggcca tcctgtctgc cagactgagc aagagcagac     7380

ggctggaaaa tctgatcgcc cagctgcccg gcgagaagaa gaatggcctg ttcggcaacc     7440

tgattgccct gagcctgggc ctgaccccca acttcaagag caacttcgac ctggccgagg     7500

atgccaaact gcagctgagc aaggacacct acgacgacga cctggacaac ctgctggccc     7560

agatcggcga ccagtacgcc gacctgtttc tggccgccaa gaacctgtcc gacgccatcc     7620

tgctgagcga catcctgaga gtgaacaccg agatcaccaa ggcccccctg agcgcctcta     7680

tgatcaagag atacgacgag caccaccagg acctgaccct gctgaaagct ctcgtgcggc     7740

agcagctgcc tgagaagtac aaagagattt tcttcgacca gagcaagaac ggctacgccg     7800

gctacattga cggcggagcc agccaggaag agttctacaa gttcatcaag cccatcctgg     7860

aaaagatgga cggcaccgag gaactgctcg tgaagctgaa cagagaggac ctgctgcgga     7920

agcagcggac cttcgacaac ggcagcatcc cccaccagat ccacctggga gagctgcacg     7980

ccattctgcg gcggcaggaa gatttttacc cattcctgaa ggacaaccgg gaaaagatcg     8040

agaagatcct gaccttccgc atcccctact acgtgggccc tctggccagg ggaaacagca     8100

gattcgcctg gatgaccaga aagagcgagg aaaccatcac cccctggaac ttcgaggaag     8160

tggtggacaa gggcgcttcc gcccagagct tcatcgagcg gatgaccaac ttcgataaga     8220

acctgcccaa cgagaaggtg ctgcccaagc acagcctgct gtacgagtac ttcaccgtgt     8280

ataacgagct gaccaaagtg aaatacgtga ccgagggaat gagaaagccc gccttcctga     8340

gcggcgagca gaaaaaggcc atcgtggacc tgctgttcaa gaccaaccgg aaagtgaccg     8400

tgaagcagct gaaagaggac tacttcaaga aaatcgagtg cttcgactcc gtggaaatct     8460

ccggcgtgga agatcggttc aacgcctccc tgggcacata ccacgatctg ctgaaaatta     8520

tcaaggacaa ggacttcctg gacaatgagg aaaacgagga cattctggaa gatatcgtgc     8580

tgaccctgac actgtttgag gacagagaga tgatcgagga acggctgaaa acctatgccc     8640

acctgttcga cgacaaagtg atgaagcagc tgaagcggcg gagatacacc ggctggggca     8700

ggctgagccg gaagctgatc aacggcatcc gggacaagca gtccggcaag acaatcctgg     8760

atttcctgaa gtccgacggc ttcgccaaca gaaacttcat gcagctgatc cacgacgaca     8820

gcctgacctt taaagaggac atccagaaag cccaggtgtc cggccagggc gatagcctgc     8880

acgagcacat tgccaatctg gccggcagcc ccgccattaa gaagggcatc ctgcagacag     8940

tgaaggtggt ggacgagctc gtgaaagtga tgggccggca caagcccgag aacatcgtga     9000

tcgaaatggc cagagagaac cagaccaccc agaagggaca gaagaacagc cgcgagagaa     9060

tgaagcggat cgaagagggc atcaaagagc tgggcagcca gatcctgaaa gaacaccccg     9120

tggaaaacac ccagctgcag aacgagaagc tgtacctgta ctacctgcag aatgggcggg     9180

atatgtacgt ggaccaggaa ctggacatca accggctgtc cgactacgat gtggaccata     9240

tcgtgcctca gagctttctg aaggacgact ccatcgacaa caaggtgctg accagaagcg     9300

acaagaaccg gggcaagagc gacaacgtgc cctccgaaga ggtcgtgaag aagatgaaga     9360

actactggcg gcagctgctg aacgccaagc tgattaccca gagaaagttc gacaatctga     9420

ccaaggccga gagaggcggc ctgagcgaac tggataaggc cggcttcatc aagagacagc     9480

tggtggaaac ccggcagatc acaaagcacg tggcacagat cctggactcc cggatgaaca     9540

ctaagtacga cgagaatgac aagctgatcc gggaagtgaa agtgatcacc ctgaagtcca     9600

agctggtgtc cgatttccgg aaggatttcc agttttacaa agtgcgcgag atcaacaact     9660

accaccacgc ccacgacgcc tacctgaacg ccgtcgtggg aaccgccctg atcaaaaagt     9720

accctaagct ggaaagcgag ttcgtgtacg gcgactacaa ggtgtacgac gtgcggaaga     9780

tgatcgccaa gagcgagcag gaaatcggca aggctaccgc caagtacttc ttctacagca     9840

acatcatgaa ctttttcaag accgagatta ccctggccaa cggcgagatc cggaagcggc     9900

ctctgatcga gacaaacggc gaaaccgggg agatcgtgtg ggataagggc cgggattttg     9960

ccaccgtgcg gaaagtgctg agcatgcccc aagtgaatat cgtgaaaaag accgaggtgc    10020

agacaggcgg cttcagcaaa gagtctatcc tgcccaagag gaacagcgat aagctgatcg    10080

ccagaaagaa ggactgggac cctaagaagt acggcggctt cgacagcccc accgtggcct    10140

attctgtgct ggtggtggcc aaagtggaaa agggcaagtc caagaaactg aagagtgtga    10200

aagagctgct ggggatcacc atcatggaaa gaagcagctt cgagaagaat cccatcgact    10260

ttctggaagc caagggctac aaagaagtga aaaaggacct gatcatcaag ctgcctaagt    10320

actccctgtt cgagctggaa aacggccgga agagaatgct ggcctctgcc ggcgaactgc    10380

agaagggaaa cgaactggcc ctgccctcca aatatgtgaa cttcctgtac ctggccagcc    10440

actatgagaa gctgaagggc tcccccgagg ataatgagca gaaacagctg tttgtggaac    10500

agcacaagca ctacctggac gagatcatcg agcagatcag cgagttctcc aagagagtga    10560

tcctggccga cgctaatctg gacaaagtgc tgtccgccta caacaagcac cgggataagc    10620

ccatcagaga gcaggccgag aatatcatcc acctgtttac cctgaccaat ctgggagccc    10680

ctgccgcctt caagtacttt gacaccacca tcgaccggaa gaggtacacc agcaccaaag    10740

aggtgctgga cgccaccctg atccaccaga gcatcaccgg cctgtacgag acacggatcg    10800

acctgtctca gctgggaggc gacagcccca agaagaagag aaaggtggag gccagcggag    10860

gcggcggtag cggaggaggc gggtccggcg gcggcggtag tgggccggcc tgattaatta    10920

agaattcgac ccagctttct tgtacaaagt ggttgatatc cagcacagtg gcggccgctc    10980

gagtctagag ggcccgcggt tcgaaggtaa gcctatccct aaccctctcc tcggtctcga    11040

ttctacgcgt accggttagc aattgttttt tcgatgagtt tggacaaacc acaactagaa    11100

tgcagtgaaa aaaatgcttt atttgtgaaa tttgtgatgc tattgcttta tttgtaacca    11160

ttataagctg caataaacaa gttaacaaca acaattgcat tcattttatg tttcaggttc    11220

agggggaggt gtgggaggtt ttttaaagca agtaaaacct ctacaaatgt ggtacttaag    11280

agggggagac caaagggcga gacgttaagg cctcacgtga catgtgagca aaaggccagc    11340

aaaaggccag gaaccgtaaa aaggccgcgt tgctggcgtt tttccatagg ctccgccccc    11400

ctgacgagca tcacaaaaat cgacgctcaa gtcagaggtg gcgaaacccg acaggactat    11460

aaagatacca ggcgtttccc cctggaagct ccctcgtgcg ctctcctgtt ccgaccctgc    11520

cgcttaccgg atacctgtcc gcctttctcc cttcgggaag cgtggcgctt tctcatagct    11580

cacgctgtag gtatctcagt tcggtgtagg tcgttcgctc caagctgggc tgtgtgcacg    11640

aaccccccgt tcagcccgac cgctgcgcct tatccggtaa ctatcgtctt gagtccaacc    11700

cggtaagaca cgacttatcg ccactggcag cagccactgg taacaggatt agcagagcga    11760

ggtatgtagg cggtgctaca gagttcttga agtggtggcc taactacggc tacactagaa    11820

ggacagtatt tggtatctgc gctctgctga agccagttac cttcggaaaa agagttggta    11880

gctcttgatc cggcaaacaa accacgctgg tagcggtggt ttttttgttt gcaagcagca    11940

gattacgcgc agaaaaaaag gatctcaaga agatcctttg atcttttcta cggggtctga    12000

cgctcagtgg aacgaaaact cacgttaagg gattttggtc atgccgtctc agaagaactc    12060

gtcaagaagg cgatagaagg cgatgcgctg cgaatcggga gcggcgatac cgtaaagcac    12120

gaggaagcgg tcagcccatt cgccgccaag ctcttcagca atatcacggg tagccaacgc    12180

tatgtcctga tagcggtccg ccacacccag ccggccacag tcgatgaatc cagaaaagcg    12240

gccattttcc accatgatat tcggcaagca ggcatcgcca tgggtcacga cgagatcctc    12300

gccgtcgggc atgctcgcct tgagcctggc gaacagttcg gctggcgcga gcccctgatg    12360

ctcttcgtcc agatcatcct gatcgacaag accggcttcc atccgagtac gtgctcgctc    12420

gatgcgatgt ttcgcttggt ggtcgaatgg gcaggtagcc ggatcaagcg tatgcagccg    12480

ccgcattgca tcagccatga tggatacttt ctcggcagga gcaaggtgag atgacaggag    12540

atcctgcccc ggcacttcgc ccaatagcag ccagtccctt cccgcttcag tgacaacgtc    12600

gagcacagct gcgcaaggaa cgcccgtcgt ggccagccac gatagccgcg ctgcctcgtc    12660

ttgcagttca ttcagggcac cggacaggtc ggtcttgaca aaaagaaccg ggcgcccctg    12720

cgctgacagc cggaacacgg cggcatcaga gcagccgatt gtctgttgtg cccagtcata    12780

gccgaatagc ctctccaccc aagcggccgg agaacctgcg tgcaatccat cttgttcaat    12840

cataatatta ttgaagcatt tatcagggtt cgtctcgtcc cggtctcctc ccatgcatg     12899


<210>  36
<211>  3301
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  36

Met Gly Pro Ala Met Asp Leu Ser Ala Leu Arg Val Glu Glu Val Gln 
1               5                   10                  15      


Asn Val Ile Asn Ala Met Gln Lys Ile Leu Glu Cys Pro Ile Cys Leu 
            20                  25                  30          


Glu Leu Ile Lys Glu Pro Val Ser Thr Lys Cys Asp His Ile Phe Cys 
        35                  40                  45              


Lys Phe Cys Met Leu Lys Leu Leu Asn Gln Lys Lys Gly Pro Ser Gln 
    50                  55                  60                  


Cys Pro Leu Cys Lys Asn Asp Ile Thr Lys Arg Ser Leu Gln Glu Ser 
65                  70                  75                  80  


Thr Arg Phe Ser Gln Leu Val Glu Glu Leu Leu Lys Ile Ile Cys Ala 
                85                  90                  95      


Phe Gln Leu Asp Thr Gly Leu Glu Tyr Ala Asn Ser Tyr Asn Phe Ala 
            100                 105                 110         


Lys Lys Glu Asn Asn Ser Pro Glu His Leu Lys Asp Glu Val Ser Ile 
        115                 120                 125             


Ile Gln Ser Met Gly Tyr Arg Asn Arg Ala Lys Arg Leu Leu Gln Ser 
    130                 135                 140                 


Glu Pro Glu Asn Pro Ser Leu Gln Glu Thr Ser Leu Ser Val Gln Leu 
145                 150                 155                 160 


Ser Asn Leu Gly Thr Val Arg Thr Leu Arg Thr Lys Gln Arg Ile Gln 
                165                 170                 175     


Pro Gln Lys Thr Ser Val Tyr Ile Glu Leu Gly Ser Asp Ser Ser Glu 
            180                 185                 190         


Asp Thr Val Asn Lys Ala Thr Tyr Cys Ser Val Gly Asp Gln Glu Leu 
        195                 200                 205             


Leu Gln Ile Thr Pro Gln Gly Thr Arg Asp Glu Ile Ser Leu Asp Ser 
    210                 215                 220                 


Ala Lys Lys Ala Ala Cys Glu Phe Ser Glu Thr Asp Val Thr Asn Thr 
225                 230                 235                 240 


Glu His His Gln Pro Ser Asn Asn Asp Leu Asn Thr Thr Glu Lys Arg 
                245                 250                 255     


Ala Ala Glu Arg His Pro Glu Lys Tyr Gln Gly Ser Ser Val Ser Asn 
            260                 265                 270         


Leu His Val Glu Pro Cys Gly Thr Asn Thr His Ala Ser Ser Leu Gln 
        275                 280                 285             


His Glu Asn Ser Ser Leu Leu Leu Thr Lys Asp Arg Met Asn Val Glu 
    290                 295                 300                 


Lys Ala Glu Phe Cys Asn Lys Ser Lys Gln Pro Gly Leu Ala Arg Ser 
305                 310                 315                 320 


Gln His Asn Arg Trp Ala Gly Ser Lys Glu Thr Cys Asn Asp Arg Arg 
                325                 330                 335     


Thr Pro Ser Thr Glu Lys Lys Val Asp Leu Asn Ala Asp Pro Leu Cys 
            340                 345                 350         


Glu Arg Lys Glu Trp Asn Lys Gln Lys Leu Pro Cys Ser Glu Asn Pro 
        355                 360                 365             


Arg Asp Thr Glu Asp Val Pro Trp Ile Thr Leu Asn Ser Ser Ile Gln 
    370                 375                 380                 


Lys Val Asn Glu Trp Phe Ser Arg Ser Asp Glu Leu Leu Gly Ser Asp 
385                 390                 395                 400 


Asp Ser His Asp Gly Glu Ser Glu Ser Asn Ala Lys Val Ala Asp Val 
                405                 410                 415     


Leu Asp Val Leu Asn Glu Val Asp Glu Tyr Ser Gly Ser Ser Glu Lys 
            420                 425                 430         


Ile Asp Leu Leu Ala Ser Asp Pro His Glu Ala Leu Ile Cys Lys Ser 
        435                 440                 445             


Glu Arg Val His Ser Lys Ser Val Glu Ser Asn Ile Glu Asp Lys Ile 
    450                 455                 460                 


Phe Gly Lys Thr Tyr Arg Lys Lys Ala Ser Leu Pro Asn Leu Ser His 
465                 470                 475                 480 


Val Thr Glu Asn Leu Ile Ile Gly Ala Phe Val Thr Glu Pro Gln Ile 
                485                 490                 495     


Ile Gln Glu Arg Pro Leu Thr Asn Lys Leu Lys Arg Lys Arg Arg Pro 
            500                 505                 510         


Thr Ser Gly Leu His Pro Glu Asp Phe Ile Lys Lys Ala Asp Leu Ala 
        515                 520                 525             


Val Gln Lys Thr Pro Glu Met Ile Asn Gln Gly Thr Asn Gln Thr Glu 
    530                 535                 540                 


Gln Asn Gly Gln Val Met Asn Ile Thr Asn Ser Gly His Glu Asn Lys 
545                 550                 555                 560 


Thr Lys Gly Asp Ser Ile Gln Asn Glu Lys Asn Pro Asn Pro Ile Glu 
                565                 570                 575     


Ser Leu Glu Lys Glu Ser Ala Phe Lys Thr Lys Ala Glu Pro Ile Ser 
            580                 585                 590         


Ser Ser Ile Ser Asn Met Glu Leu Glu Leu Asn Ile His Asn Ser Lys 
        595                 600                 605             


Ala Pro Lys Lys Asn Arg Leu Arg Arg Lys Ser Ser Thr Arg His Ile 
    610                 615                 620                 


His Ala Leu Glu Leu Val Val Ser Arg Asn Leu Ser Pro Pro Asn Cys 
625                 630                 635                 640 


Thr Glu Leu Gln Ile Asp Ser Cys Ser Ser Ser Glu Glu Ile Lys Lys 
                645                 650                 655     


Lys Lys Tyr Asn Gln Met Pro Val Arg His Ser Arg Asn Leu Gln Leu 
            660                 665                 670         


Met Glu Gly Lys Glu Pro Ala Thr Gly Ala Lys Lys Ser Asn Lys Pro 
        675                 680                 685             


Asn Glu Gln Thr Ser Lys Arg His Asp Ser Asp Thr Phe Pro Glu Leu 
    690                 695                 700                 


Lys Leu Thr Asn Ala Pro Gly Ser Phe Thr Lys Cys Ser Asn Thr Ser 
705                 710                 715                 720 


Glu Leu Lys Glu Phe Val Asn Pro Ser Leu Pro Arg Glu Glu Lys Glu 
                725                 730                 735     


Glu Lys Leu Glu Thr Val Lys Val Ser Asn Asn Ala Glu Asp Pro Lys 
            740                 745                 750         


Asp Leu Met Leu Ser Gly Glu Arg Val Leu Gln Thr Glu Arg Ser Val 
        755                 760                 765             


Glu Ser Ser Ser Ile Ser Leu Val Pro Gly Thr Asp Tyr Gly Thr Gln 
    770                 775                 780                 


Glu Ser Ile Ser Leu Leu Glu Val Ser Thr Leu Gly Lys Ala Lys Thr 
785                 790                 795                 800 


Glu Pro Asn Lys Cys Val Ser Gln Cys Ala Ala Phe Glu Asn Pro Lys 
                805                 810                 815     


Gly Leu Ile His Gly Cys Ser Lys Asp Asn Arg Asn Asp Thr Glu Gly 
            820                 825                 830         


Phe Lys Tyr Pro Leu Gly His Glu Val Asn His Ser Arg Glu Thr Ser 
        835                 840                 845             


Ile Glu Met Glu Glu Ser Glu Leu Asp Ala Gln Tyr Leu Gln Asn Thr 
    850                 855                 860                 


Phe Lys Val Ser Lys Arg Gln Ser Phe Ala Leu Phe Ser Asn Pro Gly 
865                 870                 875                 880 


Asn Ala Glu Glu Glu Cys Ala Thr Phe Ser Ala His Ser Gly Ser Leu 
                885                 890                 895     


Lys Lys Gln Ser Pro Lys Val Thr Phe Glu Cys Glu Gln Lys Glu Glu 
            900                 905                 910         


Asn Gln Gly Lys Asn Glu Ser Asn Ile Lys Pro Val Gln Thr Val Asn 
        915                 920                 925             


Ile Thr Ala Gly Phe Pro Val Val Gly Gln Lys Asp Lys Pro Val Asp 
    930                 935                 940                 


Asn Ala Lys Cys Ser Ile Lys Gly Gly Ser Arg Phe Cys Leu Ser Ser 
945                 950                 955                 960 


Gln Phe Arg Gly Asn Glu Thr Gly Leu Ile Thr Pro Asn Lys His Gly 
                965                 970                 975     


Leu Leu Gln Asn Pro Tyr Arg Ile Pro Pro Leu Phe Pro Ile Lys Ser 
            980                 985                 990         


Phe Val Lys Thr Lys Cys Lys Lys  Asn Leu Leu Glu Glu  Asn Phe Glu 
        995                 1000                 1005             


Glu His  Ser Met Ser Pro Glu  Arg Glu Met Gly Asn  Glu Asn Ile 
    1010                 1015                 1020             


Pro Ser  Thr Val Ser Thr Ile  Ser Arg Asn Asn Ile  Arg Glu Asn 
    1025                 1030                 1035             


Val Phe  Lys Gly Ala Ser Ser  Ser Asn Ile Asn Glu  Val Gly Ser 
    1040                 1045                 1050             


Ser Thr  Asn Glu Val Gly Ser  Ser Ile Asn Glu Ile  Gly Ser Ser 
    1055                 1060                 1065             


Asp Glu  Asn Ile Gln Ala Glu  Leu Gly Arg Asn Arg  Gly Pro Lys 
    1070                 1075                 1080             


Leu Asn  Ala Met Leu Arg Leu  Gly Val Leu Gln Pro  Glu Val Tyr 
    1085                 1090                 1095             


Lys Gln  Ser Leu Pro Gly Ser  Asn Cys Lys His Pro  Glu Ile Lys 
    1100                 1105                 1110             


Lys Gln  Glu Tyr Glu Glu Val  Val Gln Thr Val Asn  Thr Asp Phe 
    1115                 1120                 1125             


Ser Pro  Tyr Leu Ile Ser Asp  Asn Leu Glu Gln Pro  Met Gly Ser 
    1130                 1135                 1140             


Ser His  Thr Ser Gln Val Cys  Ser Glu Thr Pro Asp  Asp Leu Leu 
    1145                 1150                 1155             


Asp Asp  Gly Glu Ile Lys Glu  Asp Thr Ser Phe Ala  Glu Asn Asp 
    1160                 1165                 1170             


Ile Lys  Glu Ser Ser Ala Val  Phe Ser Lys Ser Val  Gln Arg Gly 
    1175                 1180                 1185             


Glu Leu  Ser Arg Ser Pro Ser  Pro Phe Thr His Thr  His Leu Ala 
    1190                 1195                 1200             


Gln Gly  Tyr Arg Arg Gly Ala  Lys Lys Leu Glu Ser  Ser Glu Glu 
    1205                 1210                 1215             


Asn Leu  Ser Ser Glu Asp Glu  Glu Leu Pro Cys Phe  Gln His Leu 
    1220                 1225                 1230             


Leu Phe  Gly Lys Val Asn Asn  Ile Pro Ser Gln Ser  Thr Arg His 
    1235                 1240                 1245             


Ser Thr  Val Ala Thr Glu Cys  Leu Ser Lys Asn Thr  Glu Glu Asn 
    1250                 1255                 1260             


Leu Leu  Ser Leu Lys Asn Ser  Leu Asn Asp Cys Ser  Asn Gln Val 
    1265                 1270                 1275             


Ile Leu  Ala Lys Ala Ser Gln  Glu His His Leu Ser  Glu Glu Thr 
    1280                 1285                 1290             


Lys Cys  Ser Ala Ser Leu Phe  Ser Ser Gln Cys Ser  Glu Leu Glu 
    1295                 1300                 1305             


Asp Leu  Thr Ala Asn Thr Asn  Thr Gln Asp Pro Phe  Leu Ile Gly 
    1310                 1315                 1320             


Ser Ser  Lys Gln Met Arg His  Gln Ser Glu Ser Gln  Gly Val Gly 
    1325                 1330                 1335             


Leu Ser  Asp Lys Glu Leu Val  Ser Asp Asp Glu Glu  Arg Gly Thr 
    1340                 1345                 1350             


Gly Leu  Glu Glu Asn Asn Gln  Glu Glu Gln Ser Met  Asp Ser Asn 
    1355                 1360                 1365             


Leu Gly  Glu Ala Ala Ser Gly  Cys Glu Ser Glu Thr  Ser Val Ser 
    1370                 1375                 1380             


Glu Asp  Cys Ser Gly Leu Ser  Ser Gln Ser Asp Ile  Leu Thr Thr 
    1385                 1390                 1395             


Gln Gln  Arg Asp Thr Met Gln  His Asn Leu Ile Lys  Leu Gln Gln 
    1400                 1405                 1410             


Glu Met  Ala Glu Leu Glu Ala  Val Leu Glu Gln His  Gly Ser Gln 
    1415                 1420                 1425             


Pro Ser  Asn Ser Tyr Pro Ser  Ile Ile Ser Asp Ser  Ser Ala Leu 
    1430                 1435                 1440             


Glu Asp  Leu Arg Asn Pro Glu  Gln Ser Thr Ser Glu  Lys Ala Val 
    1445                 1450                 1455             


Leu Thr  Ser Gln Lys Ser Ser  Glu Tyr Pro Ile Ser  Gln Asn Pro 
    1460                 1465                 1470             


Glu Gly  Leu Ser Ala Asp Lys  Phe Glu Val Ser Ala  Asp Ser Ser 
    1475                 1480                 1485             


Thr Ser  Lys Asn Lys Glu Pro  Gly Val Glu Arg Ser  Ser Pro Ser 
    1490                 1495                 1500             


Lys Cys  Pro Ser Leu Asp Asp  Arg Trp Tyr Met His  Ser Cys Ser 
    1505                 1510                 1515             


Gly Ser  Leu Gln Asn Arg Asn  Tyr Pro Ser Gln Glu  Glu Leu Ile 
    1520                 1525                 1530             


Lys Val  Val Asp Val Glu Glu  Gln Gln Leu Glu Glu  Ser Gly Pro 
    1535                 1540                 1545             


His Asp  Leu Thr Glu Thr Ser  Tyr Leu Pro Arg Gln  Asp Leu Glu 
    1550                 1555                 1560             


Gly Thr  Pro Tyr Leu Glu Ser  Gly Ile Ser Leu Phe  Ser Asp Asp 
    1565                 1570                 1575             


Pro Glu  Ser Asp Pro Ser Glu  Asp Arg Ala Pro Glu  Ser Ala Arg 
    1580                 1585                 1590             


Val Gly  Asn Ile Pro Ser Ser  Thr Ser Ala Leu Lys  Val Pro Gln 
    1595                 1600                 1605             


Leu Lys  Val Ala Glu Ser Ala  Gln Gly Pro Ala Ala  Ala His Thr 
    1610                 1615                 1620             


Thr Asp  Thr Ala Gly Tyr Asn  Ala Met Glu Glu Ser  Val Ser Arg 
    1625                 1630                 1635             


Glu Lys  Pro Glu Leu Thr Ala  Ser Thr Glu Arg Val  Asn Lys Arg 
    1640                 1645                 1650             


Met Ser  Met Val Val Ser Gly  Leu Thr Pro Glu Glu  Phe Met Leu 
    1655                 1660                 1665             


Val Tyr  Lys Phe Ala Arg Lys  His His Ile Thr Leu  Thr Asn Leu 
    1670                 1675                 1680             


Ile Thr  Glu Glu Thr Thr His  Val Val Met Lys Thr  Asp Ala Glu 
    1685                 1690                 1695             


Phe Val  Cys Glu Arg Thr Leu  Lys Tyr Phe Leu Gly  Ile Ala Gly 
    1700                 1705                 1710             


Gly Lys  Trp Val Val Ser Tyr  Phe Trp Val Thr Gln  Ser Ile Lys 
    1715                 1720                 1725             


Glu Arg  Lys Met Leu Asn Glu  His Asp Phe Glu Val  Arg Gly Asp 
    1730                 1735                 1740             


Val Val  Asn Gly Arg Asn His  Gln Gly Pro Lys Arg  Ala Arg Glu 
    1745                 1750                 1755             


Ser Gln  Asp Arg Lys Ile Phe  Arg Gly Leu Glu Ile  Cys Cys Tyr 
    1760                 1765                 1770             


Gly Pro  Phe Thr Asn Met Pro  Thr Asp Gln Leu Glu  Trp Met Val 
    1775                 1780                 1785             


Gln Leu  Cys Gly Ala Ser Val  Val Lys Glu Leu Ser  Ser Phe Thr 
    1790                 1795                 1800             


Leu Gly  Thr Gly Val His Pro  Ile Val Val Val Gln  Pro Asp Ala 
    1805                 1810                 1815             


Trp Thr  Glu Asp Asn Gly Phe  His Ala Ile Gly Gln  Met Cys Glu 
    1820                 1825                 1830             


Ala Pro  Val Val Thr Arg Glu  Trp Val Leu Asp Ser  Val Ala Leu 
    1835                 1840                 1845             


Tyr Gln  Cys Gln Glu Leu Asp  Thr Tyr Leu Ile Pro  Gln Ile Pro 
    1850                 1855                 1860             


His Ser  His Tyr Ile Asp Gly  Gly Gly Gly Ser Gly  Gly Gly Gly 
    1865                 1870                 1875             


Ser Gly  Gly Gly Gly Ser Met  Tyr Pro Tyr Asp Val  Pro Asp Tyr 
    1880                 1885                 1890             


Ala Ser  Pro Lys Lys Lys Arg  Lys Val Glu Ala Ser  Asp Lys Lys 
    1895                 1900                 1905             


Tyr Ser  Ile Gly Leu Asp Ile  Gly Thr Asn Ser Val  Gly Trp Ala 
    1910                 1915                 1920             


Val Ile  Thr Asp Glu Tyr Lys  Val Pro Ser Lys Lys  Phe Lys Val 
    1925                 1930                 1935             


Leu Gly  Asn Thr Asp Arg His  Ser Ile Lys Lys Asn  Leu Ile Gly 
    1940                 1945                 1950             


Ala Leu  Leu Phe Asp Ser Gly  Glu Thr Ala Glu Ala  Thr Arg Leu 
    1955                 1960                 1965             


Lys Arg  Thr Ala Arg Arg Arg  Tyr Thr Arg Arg Lys  Asn Arg Ile 
    1970                 1975                 1980             


Cys Tyr  Leu Gln Glu Ile Phe  Ser Asn Glu Met Ala  Lys Val Asp 
    1985                 1990                 1995             


Asp Ser  Phe Phe His Arg Leu  Glu Glu Ser Phe Leu  Val Glu Glu 
    2000                 2005                 2010             


Asp Lys  Lys His Glu Arg His  Pro Ile Phe Gly Asn  Ile Val Asp 
    2015                 2020                 2025             


Glu Val  Ala Tyr His Glu Lys  Tyr Pro Thr Ile Tyr  His Leu Arg 
    2030                 2035                 2040             


Lys Lys  Leu Val Asp Ser Thr  Asp Lys Ala Asp Leu  Arg Leu Ile 
    2045                 2050                 2055             


Tyr Leu  Ala Leu Ala His Met  Ile Lys Phe Arg Gly  His Phe Leu 
    2060                 2065                 2070             


Ile Glu  Gly Asp Leu Asn Pro  Asp Asn Ser Asp Val  Asp Lys Leu 
    2075                 2080                 2085             


Phe Ile  Gln Leu Val Gln Thr  Tyr Asn Gln Leu Phe  Glu Glu Asn 
    2090                 2095                 2100             


Pro Ile  Asn Ala Ser Gly Val  Asp Ala Lys Ala Ile  Leu Ser Ala 
    2105                 2110                 2115             


Arg Leu  Ser Lys Ser Arg Arg  Leu Glu Asn Leu Ile  Ala Gln Leu 
    2120                 2125                 2130             


Pro Gly  Glu Lys Lys Asn Gly  Leu Phe Gly Asn Leu  Ile Ala Leu 
    2135                 2140                 2145             


Ser Leu  Gly Leu Thr Pro Asn  Phe Lys Ser Asn Phe  Asp Leu Ala 
    2150                 2155                 2160             


Glu Asp  Ala Lys Leu Gln Leu  Ser Lys Asp Thr Tyr  Asp Asp Asp 
    2165                 2170                 2175             


Leu Asp  Asn Leu Leu Ala Gln  Ile Gly Asp Gln Tyr  Ala Asp Leu 
    2180                 2185                 2190             


Phe Leu  Ala Ala Lys Asn Leu  Ser Asp Ala Ile Leu  Leu Ser Asp 
    2195                 2200                 2205             


Ile Leu  Arg Val Asn Thr Glu  Ile Thr Lys Ala Pro  Leu Ser Ala 
    2210                 2215                 2220             


Ser Met  Ile Lys Arg Tyr Asp  Glu His His Gln Asp  Leu Thr Leu 
    2225                 2230                 2235             


Leu Lys  Ala Leu Val Arg Gln  Gln Leu Pro Glu Lys  Tyr Lys Glu 
    2240                 2245                 2250             


Ile Phe  Phe Asp Gln Ser Lys  Asn Gly Tyr Ala Gly  Tyr Ile Asp 
    2255                 2260                 2265             


Gly Gly  Ala Ser Gln Glu Glu  Phe Tyr Lys Phe Ile  Lys Pro Ile 
    2270                 2275                 2280             


Leu Glu  Lys Met Asp Gly Thr  Glu Glu Leu Leu Val  Lys Leu Asn 
    2285                 2290                 2295             


Arg Glu  Asp Leu Leu Arg Lys  Gln Arg Thr Phe Asp  Asn Gly Ser 
    2300                 2305                 2310             


Ile Pro  His Gln Ile His Leu  Gly Glu Leu His Ala  Ile Leu Arg 
    2315                 2320                 2325             


Arg Gln  Glu Asp Phe Tyr Pro  Phe Leu Lys Asp Asn  Arg Glu Lys 
    2330                 2335                 2340             


Ile Glu  Lys Ile Leu Thr Phe  Arg Ile Pro Tyr Tyr  Val Gly Pro 
    2345                 2350                 2355             


Leu Ala  Arg Gly Asn Ser Arg  Phe Ala Trp Met Thr  Arg Lys Ser 
    2360                 2365                 2370             


Glu Glu  Thr Ile Thr Pro Trp  Asn Phe Glu Glu Val  Val Asp Lys 
    2375                 2380                 2385             


Gly Ala  Ser Ala Gln Ser Phe  Ile Glu Arg Met Thr  Asn Phe Asp 
    2390                 2395                 2400             


Lys Asn  Leu Pro Asn Glu Lys  Val Leu Pro Lys His  Ser Leu Leu 
    2405                 2410                 2415             


Tyr Glu  Tyr Phe Thr Val Tyr  Asn Glu Leu Thr Lys  Val Lys Tyr 
    2420                 2425                 2430             


Val Thr  Glu Gly Met Arg Lys  Pro Ala Phe Leu Ser  Gly Glu Gln 
    2435                 2440                 2445             


Lys Lys  Ala Ile Val Asp Leu  Leu Phe Lys Thr Asn  Arg Lys Val 
    2450                 2455                 2460             


Thr Val  Lys Gln Leu Lys Glu  Asp Tyr Phe Lys Lys  Ile Glu Cys 
    2465                 2470                 2475             


Phe Asp  Ser Val Glu Ile Ser  Gly Val Glu Asp Arg  Phe Asn Ala 
    2480                 2485                 2490             


Ser Leu  Gly Thr Tyr His Asp  Leu Leu Lys Ile Ile  Lys Asp Lys 
    2495                 2500                 2505             


Asp Phe  Leu Asp Asn Glu Glu  Asn Glu Asp Ile Leu  Glu Asp Ile 
    2510                 2515                 2520             


Val Leu  Thr Leu Thr Leu Phe  Glu Asp Arg Glu Met  Ile Glu Glu 
    2525                 2530                 2535             


Arg Leu  Lys Thr Tyr Ala His  Leu Phe Asp Asp Lys  Val Met Lys 
    2540                 2545                 2550             


Gln Leu  Lys Arg Arg Arg Tyr  Thr Gly Trp Gly Arg  Leu Ser Arg 
    2555                 2560                 2565             


Lys Leu  Ile Asn Gly Ile Arg  Asp Lys Gln Ser Gly  Lys Thr Ile 
    2570                 2575                 2580             


Leu Asp  Phe Leu Lys Ser Asp  Gly Phe Ala Asn Arg  Asn Phe Met 
    2585                 2590                 2595             


Gln Leu  Ile His Asp Asp Ser  Leu Thr Phe Lys Glu  Asp Ile Gln 
    2600                 2605                 2610             


Lys Ala  Gln Val Ser Gly Gln  Gly Asp Ser Leu His  Glu His Ile 
    2615                 2620                 2625             


Ala Asn  Leu Ala Gly Ser Pro  Ala Ile Lys Lys Gly  Ile Leu Gln 
    2630                 2635                 2640             


Thr Val  Lys Val Val Asp Glu  Leu Val Lys Val Met  Gly Arg His 
    2645                 2650                 2655             


Lys Pro  Glu Asn Ile Val Ile  Glu Met Ala Arg Glu  Asn Gln Thr 
    2660                 2665                 2670             


Thr Gln  Lys Gly Gln Lys Asn  Ser Arg Glu Arg Met  Lys Arg Ile 
    2675                 2680                 2685             


Glu Glu  Gly Ile Lys Glu Leu  Gly Ser Gln Ile Leu  Lys Glu His 
    2690                 2695                 2700             


Pro Val  Glu Asn Thr Gln Leu  Gln Asn Glu Lys Leu  Tyr Leu Tyr 
    2705                 2710                 2715             


Tyr Leu  Gln Asn Gly Arg Asp  Met Tyr Val Asp Gln  Glu Leu Asp 
    2720                 2725                 2730             


Ile Asn  Arg Leu Ser Asp Tyr  Asp Val Asp His Ile  Val Pro Gln 
    2735                 2740                 2745             


Ser Phe  Leu Lys Asp Asp Ser  Ile Asp Asn Lys Val  Leu Thr Arg 
    2750                 2755                 2760             


Ser Asp  Lys Asn Arg Gly Lys  Ser Asp Asn Val Pro  Ser Glu Glu 
    2765                 2770                 2775             


Val Val  Lys Lys Met Lys Asn  Tyr Trp Arg Gln Leu  Leu Asn Ala 
    2780                 2785                 2790             


Lys Leu  Ile Thr Gln Arg Lys  Phe Asp Asn Leu Thr  Lys Ala Glu 
    2795                 2800                 2805             


Arg Gly  Gly Leu Ser Glu Leu  Asp Lys Ala Gly Phe  Ile Lys Arg 
    2810                 2815                 2820             


Gln Leu  Val Glu Thr Arg Gln  Ile Thr Lys His Val  Ala Gln Ile 
    2825                 2830                 2835             


Leu Asp  Ser Arg Met Asn Thr  Lys Tyr Asp Glu Asn  Asp Lys Leu 
    2840                 2845                 2850             


Ile Arg  Glu Val Lys Val Ile  Thr Leu Lys Ser Lys  Leu Val Ser 
    2855                 2860                 2865             


Asp Phe  Arg Lys Asp Phe Gln  Phe Tyr Lys Val Arg  Glu Ile Asn 
    2870                 2875                 2880             


Asn Tyr  His His Ala His Asp  Ala Tyr Leu Asn Ala  Val Val Gly 
    2885                 2890                 2895             


Thr Ala  Leu Ile Lys Lys Tyr  Pro Lys Leu Glu Ser  Glu Phe Val 
    2900                 2905                 2910             


Tyr Gly  Asp Tyr Lys Val Tyr  Asp Val Arg Lys Met  Ile Ala Lys 
    2915                 2920                 2925             


Ser Glu  Gln Glu Ile Gly Lys  Ala Thr Ala Lys Tyr  Phe Phe Tyr 
    2930                 2935                 2940             


Ser Asn  Ile Met Asn Phe Phe  Lys Thr Glu Ile Thr  Leu Ala Asn 
    2945                 2950                 2955             


Gly Glu  Ile Arg Lys Arg Pro  Leu Ile Glu Thr Asn  Gly Glu Thr 
    2960                 2965                 2970             


Gly Glu  Ile Val Trp Asp Lys  Gly Arg Asp Phe Ala  Thr Val Arg 
    2975                 2980                 2985             


Lys Val  Leu Ser Met Pro Gln  Val Asn Ile Val Lys  Lys Thr Glu 
    2990                 2995                 3000             


Val Gln  Thr Gly Gly Phe Ser  Lys Glu Ser Ile Leu  Pro Lys Arg 
    3005                 3010                 3015             


Asn Ser  Asp Lys Leu Ile Ala  Arg Lys Lys Asp Trp  Asp Pro Lys 
    3020                 3025                 3030             


Lys Tyr  Gly Gly Phe Asp Ser  Pro Thr Val Ala Tyr  Ser Val Leu 
    3035                 3040                 3045             


Val Val  Ala Lys Val Glu Lys  Gly Lys Ser Lys Lys  Leu Lys Ser 
    3050                 3055                 3060             


Val Lys  Glu Leu Leu Gly Ile  Thr Ile Met Glu Arg  Ser Ser Phe 
    3065                 3070                 3075             


Glu Lys  Asn Pro Ile Asp Phe  Leu Glu Ala Lys Gly  Tyr Lys Glu 
    3080                 3085                 3090             


Val Lys  Lys Asp Leu Ile Ile  Lys Leu Pro Lys Tyr  Ser Leu Phe 
    3095                 3100                 3105             


Glu Leu  Glu Asn Gly Arg Lys  Arg Met Leu Ala Ser  Ala Gly Glu 
    3110                 3115                 3120             


Leu Gln  Lys Gly Asn Glu Leu  Ala Leu Pro Ser Lys  Tyr Val Asn 
    3125                 3130                 3135             


Phe Leu  Tyr Leu Ala Ser His  Tyr Glu Lys Leu Lys  Gly Ser Pro 
    3140                 3145                 3150             


Glu Asp  Asn Glu Gln Lys Gln  Leu Phe Val Glu Gln  His Lys His 
    3155                 3160                 3165             


Tyr Leu  Asp Glu Ile Ile Glu  Gln Ile Ser Glu Phe  Ser Lys Arg 
    3170                 3175                 3180             


Val Ile  Leu Ala Asp Ala Asn  Leu Asp Lys Val Leu  Ser Ala Tyr 
    3185                 3190                 3195             


Asn Lys  His Arg Asp Lys Pro  Ile Arg Glu Gln Ala  Glu Asn Ile 
    3200                 3205                 3210             


Ile His  Leu Phe Thr Leu Thr  Asn Leu Gly Ala Pro  Ala Ala Phe 
    3215                 3220                 3225             


Lys Tyr  Phe Asp Thr Thr Ile  Asp Arg Lys Arg Tyr  Thr Ser Thr 
    3230                 3235                 3240             


Lys Glu  Val Leu Asp Ala Thr  Leu Ile His Gln Ser  Ile Thr Gly 
    3245                 3250                 3255             


Leu Tyr  Glu Thr Arg Ile Asp  Leu Ser Gln Leu Gly  Gly Asp Ser 
    3260                 3265                 3270             


Pro Lys  Lys Lys Arg Lys Val  Glu Ala Ser Gly Gly  Gly Gly Ser 
    3275                 3280                 3285             


Gly Gly  Gly Gly Ser Gly Gly  Gly Gly Ser Gly Pro  Ala 
    3290                 3295                 3300     


<210>  37
<211>  12896
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide

<400>  37
tcaatattgg ccattagcca tattattcat tggttatata gcataaatca atattggcta       60

ttggccattg catacgttgt atctatatca taatatgtac atttatattg gctcatgtcc      120

aatatgaccg ccatgttggc attgattatt gactagttat taatagtaat caattacggg      180

gtcattagtt catagcccat atatggagtt ccgcgttaca taacttacgg taaatggccc      240

gcctggctga ccgcccaacg acccccgccc attgacgtca ataatgacgt atgttcccat      300

agtaacgcca atagggactt tccattgacg tcaatgggtg gagtatttac ggtaaactgc      360

ccacttggca gtacatcaag tgtatcatat gccaagtccg ccccctattg acgtcaatga      420

cggtaaatgg cccgcctggc attatgccca gtacatgacc ttacgggact ttcctacttg      480

gcagtacatc tacgtattag tcatcgctat taccatggtg atgcggtttt ggcagtacac      540

caatgggcgt ggatagcggt ttgactcacg gggatttcca agtctccacc ccattgacgt      600

caatgggagt ttgttttggc accaaaatca acgggacttt ccaaaatgtc gtaataaccc      660

cgccccgttg acgcaaatgg gcggtaggcg tgtacggtgg gaggtctata taagcagagg      720

tcgtttagtg aaccgtcaga tcactagtag ctttattgcg gtagtttatc acagttaaat      780

tgctaacgca gtcagtgctc gactgatcac aggtaagtat caaggttaca agacaggttt      840

aaggaggcca atagaaactg ggcttgtcga gacagagaag attcttgcgt ttctgatagg      900

cacctattgg tcttactgac atccactttg cctttctctc cacagggaaa aaacaattga      960

caagtttgta caaaaaagca ggctccgaat tcaccggtgc cgccaccatg atcgatggtg     1020

gcggtggtag cgggggaggc ggctccgggg gcggaggcag tatgtaccca tacgatgttc     1080

cagattacgc ttcgccgaag aaaaagcgca aggtcgaagc gtccgacaag aagtacagca     1140

tcggcctgga catcggcacc aactctgtgg gctgggccgt gatcaccgac gagtacaagg     1200

tgcccagcaa gaaattcaag gtgctgggca acaccgaccg gcacagcatc aagaagaacc     1260

tgatcggagc cctgctgttc gacagcggcg aaacagccga ggccacccgg ctgaagagaa     1320

ccgccagaag aagatacacc agacggaaga accggatctg ctatctgcaa gagatcttca     1380

gcaacgagat ggccaaggtg gacgacagct tcttccacag actggaagag tccttcctgg     1440

tggaagagga taagaagcac gagcggcacc ccatcttcgg caacatcgtg gacgaggtgg     1500

cctaccacga gaagtacccc accatctacc acctgagaaa gaaactggtg gacagcaccg     1560

acaaggccga cctgcggctg atctatctgg ccctggccca catgatcaag ttccggggcc     1620

acttcctgat cgagggcgac ctgaaccccg acaacagcga cgtggacaag ctgttcatcc     1680

agctggtgca gacctacaac cagctgttcg aggaaaaccc catcaacgcc agcggcgtgg     1740

acgccaaggc catcctgtct gccagactga gcaagagcag acggctggaa aatctgatcg     1800

cccagctgcc cggcgagaag aagaatggcc tgttcggcaa cctgattgcc ctgagcctgg     1860

gcctgacccc caacttcaag agcaacttcg acctggccga ggatgccaaa ctgcagctga     1920

gcaaggacac ctacgacgac gacctggaca acctgctggc ccagatcggc gaccagtacg     1980

ccgacctgtt tctggccgcc aagaacctgt ccgacgccat cctgctgagc gacatcctga     2040

gagtgaacac cgagatcacc aaggcccccc tgagcgcctc tatgatcaag agatacgacg     2100

agcaccacca ggacctgacc ctgctgaaag ctctcgtgcg gcagcagctg cctgagaagt     2160

acaaagagat tttcttcgac cagagcaaga acggctacgc cggctacatt gacggcggag     2220

ccagccagga agagttctac aagttcatca agcccatcct ggaaaagatg gacggcaccg     2280

aggaactgct cgtgaagctg aacagagagg acctgctgcg gaagcagcgg accttcgaca     2340

acggcagcat cccccaccag atccacctgg gagagctgca cgccattctg cggcggcagg     2400

aagattttta cccattcctg aaggacaacc gggaaaagat cgagaagatc ctgaccttcc     2460

gcatccccta ctacgtgggc cctctggcca ggggaaacag cagattcgcc tggatgacca     2520

gaaagagcga ggaaaccatc accccctgga acttcgagga agtggtggac aagggcgctt     2580

ccgcccagag cttcatcgag cggatgacca acttcgataa gaacctgccc aacgagaagg     2640

tgctgcccaa gcacagcctg ctgtacgagt acttcaccgt gtataacgag ctgaccaaag     2700

tgaaatacgt gaccgaggga atgagaaagc ccgccttcct gagcggcgag cagaaaaagg     2760

ccatcgtgga cctgctgttc aagaccaacc ggaaagtgac cgtgaagcag ctgaaagagg     2820

actacttcaa gaaaatcgag tgcttcgact ccgtggaaat ctccggcgtg gaagatcggt     2880

tcaacgcctc cctgggcaca taccacgatc tgctgaaaat tatcaaggac aaggacttcc     2940

tggacaatga ggaaaacgag gacattctgg aagatatcgt gctgaccctg acactgtttg     3000

aggacagaga gatgatcgag gaacggctga aaacctatgc ccacctgttc gacgacaaag     3060

tgatgaagca gctgaagcgg cggagataca ccggctgggg caggctgagc cggaagctga     3120

tcaacggcat ccgggacaag cagtccggca agacaatcct ggatttcctg aagtccgacg     3180

gcttcgccaa cagaaacttc atgcagctga tccacgacga cagcctgacc tttaaagagg     3240

acatccagaa agcccaggtg tccggccagg gcgatagcct gcacgagcac attgccaatc     3300

tggccggcag ccccgccatt aagaagggca tcctgcagac agtgaaggtg gtggacgagc     3360

tcgtgaaagt gatgggccgg cacaagcccg agaacatcgt gatcgaaatg gccagagaga     3420

accagaccac ccagaaggga cagaagaaca gccgcgagag aatgaagcgg atcgaagagg     3480

gcatcaaaga gctgggcagc cagatcctga aagaacaccc cgtggaaaac acccagctgc     3540

agaacgagaa gctgtacctg tactacctgc agaatgggcg ggatatgtac gtggaccagg     3600

aactggacat caaccggctg tccgactacg atgtggacca tatcgtgcct cagagctttc     3660

tgaaggacga ctccatcgac aacaaggtgc tgaccagaag cgacaagaac cggggcaaga     3720

gcgacaacgt gccctccgaa gaggtcgtga agaagatgaa gaactactgg cggcagctgc     3780

tgaacgccaa gctgattacc cagagaaagt tcgacaatct gaccaaggcc gagagaggcg     3840

gcctgagcga actggataag gccggcttca tcaagagaca gctggtggaa acccggcaga     3900

tcacaaagca cgtggcacag atcctggact cccggatgaa cactaagtac gacgagaatg     3960

acaagctgat ccgggaagtg aaagtgatca ccctgaagtc caagctggtg tccgatttcc     4020

ggaaggattt ccagttttac aaagtgcgcg agatcaacaa ctaccaccac gcccacgacg     4080

cctacctgaa cgccgtcgtg ggaaccgccc tgatcaaaaa gtaccctaag ctggaaagcg     4140

agttcgtgta cggcgactac aaggtgtacg acgtgcggaa gatgatcgcc aagagcgagc     4200

aggaaatcgg caaggctacc gccaagtact tcttctacag caacatcatg aactttttca     4260

agaccgagat taccctggcc aacggcgaga tccggaagcg gcctctgatc gagacaaacg     4320

gcgaaaccgg ggagatcgtg tgggataagg gccgggattt tgccaccgtg cggaaagtgc     4380

tgagcatgcc ccaagtgaat atcgtgaaaa agaccgaggt gcagacaggc ggcttcagca     4440

aagagtctat cctgcccaag aggaacagcg ataagctgat cgccagaaag aaggactggg     4500

accctaagaa gtacggcggc ttcgacagcc ccaccgtggc ctattctgtg ctggtggtgg     4560

ccaaagtgga aaagggcaag tccaagaaac tgaagagtgt gaaagagctg ctggggatca     4620

ccatcatgga aagaagcagc ttcgagaaga atcccatcga ctttctggaa gccaagggct     4680

acaaagaagt gaaaaaggac ctgatcatca agctgcctaa gtactccctg ttcgagctgg     4740

aaaacggccg gaagagaatg ctggcctctg ccggcgaact gcagaaggga aacgaactgg     4800

ccctgccctc caaatatgtg aacttcctgt acctggccag ccactatgag aagctgaagg     4860

gctcccccga ggataatgag cagaaacagc tgtttgtgga acagcacaag cactacctgg     4920

acgagatcat cgagcagatc agcgagttct ccaagagagt gatcctggcc gacgctaatc     4980

tggacaaagt gctgtccgcc tacaacaagc accgggataa gcccatcaga gagcaggccg     5040

agaatatcat ccacctgttt accctgacca atctgggagc ccctgccgcc ttcaagtact     5100

ttgacaccac catcgaccgg aagaggtaca ccagcaccaa agaggtgctg gacgccaccc     5160

tgatccacca gagcatcacc ggcctgtacg agacacggat cgacctgtct cagctgggag     5220

gcgacagccc caagaagaag agaaaggtgg aggccagcgg aggcggcggt agcggaggag     5280

gcgggtccgg cggcggcggt agtgggccgg ccatggattt atctgctctt cgcgttgaag     5340

aagtacaaaa tgtcattaat gctatgcaga aaatcttaga gtgtcccatc tgtctggagt     5400

tgatcaagga acctgtctcc acaaagtgtg accacatatt ttgcaaattt tgcatgctga     5460

aacttctcaa ccagaagaaa gggccttcac agtgtccttt atgtaagaat gatataacca     5520

aaaggagcct acaagaaagt acgagattta gtcaacttgt tgaagagcta ttgaaaatca     5580

tttgtgcttt tcagcttgac acaggtttgg agtatgcaaa cagctataat tttgcaaaaa     5640

aggaaaataa ctctcctgaa catctaaaag atgaagtttc tatcatccaa agtatgggct     5700

acagaaaccg tgccaaaaga cttctacaga gtgaacccga aaatccttcc ttgcaggaaa     5760

ccagtctcag tgtccaactc tctaaccttg gaactgtgag aactctgagg acaaagcagc     5820

ggatacaacc tcaaaagacg tctgtctaca ttgaattggg atctgattct tctgaagata     5880

ccgttaataa ggcaacttat tgcagtgtgg gagatcaaga attgttacaa atcacccctc     5940

aaggaaccag ggatgaaatc agtttggatt ctgcaaaaaa ggctgcttgt gaattttctg     6000

agacggatgt aacaaatact gaacatcatc aacccagtaa taatgatttg aacaccactg     6060

agaagcgtgc agctgagagg catccagaaa agtatcaggg tagttctgtt tcaaacttgc     6120

atgtggagcc atgtggcaca aatactcatg ccagctcatt acagcatgag aacagcagtt     6180

tattactcac taaagacaga atgaatgtag aaaaggctga attctgtaat aaaagcaaac     6240

agcctggctt agcaaggagc caacataaca gatgggctgg aagtaaggaa acatgtaatg     6300

ataggcggac tcccagcaca gaaaaaaagg tagatctgaa tgctgatccc ctgtgtgaga     6360

gaaaagaatg gaataagcag aaactgccat gctcagagaa tcctagagat actgaagatg     6420

ttccttggat aacactaaat agcagcattc agaaagttaa tgagtggttt tccagaagtg     6480

atgaactgtt aggttctgat gactcacatg atggggagtc tgaatcaaat gccaaagtag     6540

ctgatgtatt ggacgttcta aatgaggtag atgaatattc tggttcttca gagaaaatag     6600

acttactggc cagtgatcct catgaggctt taatatgtaa aagtgaaaga gttcactcca     6660

aatcagtaga gagtaatatt gaagacaaaa tatttgggaa aacctatcgg aagaaggcaa     6720

gcctccccaa cttaagccat gtaactgaaa atctaattat aggagcattt gttactgagc     6780

cacagataat acaagagcgt cccctcacaa ataaattaaa gcgtaaaagg agacctacat     6840

caggccttca tcctgaggat tttatcaaga aagcagattt ggcagttcaa aagactcctg     6900

aaatgataaa tcagggaact aaccaaacgg agcagaatgg tcaagtgatg aatattacta     6960

atagtggtca tgagaataaa acaaaaggtg attctattca gaatgagaaa aatcctaacc     7020

caatagaatc actcgaaaaa gaatctgctt tcaaaacgaa agctgaacct ataagcagca     7080

gtataagcaa tatggaactc gaattaaata tccacaattc aaaagcacct aaaaagaata     7140

ggctgaggag gaagtcttct accaggcata ttcatgcgct tgaactagta gtcagtagaa     7200

atctaagccc acctaattgt actgaattgc aaattgatag ttgttctagc agtgaagaga     7260

taaagaaaaa aaagtacaac caaatgccag tcaggcacag cagaaaccta caactcatgg     7320

aaggtaaaga acctgcaact ggagccaaga agagtaacaa gccaaatgaa cagacaagta     7380

aaagacatga cagtgatact ttcccagagc tgaagttaac aaatgcacct ggttctttta     7440

ctaagtgttc aaataccagt gaacttaaag aatttgtcaa tcctagcctt ccaagagaag     7500

aaaaagaaga gaaactagaa acagttaaag tgtctaataa tgctgaagac cccaaagatc     7560

tcatgttaag tggagaaagg gttttgcaaa ctgaaagatc tgtagagagt agcagtattt     7620

cactggtacc tggtactgat tatggcactc aggaaagtat ctcgttactg gaagttagca     7680

ctctagggaa ggcaaaaaca gaaccaaata aatgtgtgag tcagtgtgca gcatttgaaa     7740

accccaaggg actaattcat ggttgttcca aagataatag aaatgacaca gaaggcttta     7800

agtatccatt gggacatgaa gttaaccaca gtcgggaaac aagcatagaa atggaagaaa     7860

gtgaacttga tgctcagtat ttgcagaata cattcaaggt ttcaaagcgc cagtcatttg     7920

ctctgttttc aaatccagga aatgcagaag aggaatgtgc aacattctct gcccactctg     7980

ggtccttaaa gaaacaaagt ccaaaagtca cttttgaatg tgaacaaaag gaagaaaatc     8040

aaggaaagaa tgagtctaat atcaagcctg tacagacagt taatatcact gcaggctttc     8100

ctgtggttgg tcagaaagat aagccagttg ataatgccaa atgtagtatc aaaggaggct     8160

ctaggttttg tctatcatct cagttcagag gcaacgaaac tggactcatt actccaaata     8220

aacatggact tttacaaaac ccatatcgta taccaccact ttttcccatc aagtcatttg     8280

ttaaaactaa atgtaagaaa aatctgctag aggaaaactt tgaggaacat tcaatgtcac     8340

ctgaaagaga aatgggaaat gagaacattc caagtacagt gagcacaatt agccgtaata     8400

acattagaga aaatgttttt aaaggagcca gctcaagcaa tattaatgaa gtaggttcca     8460

gtactaatga agtgggctcc agtattaatg aaataggttc cagtgatgaa aacattcaag     8520

cagaactagg tagaaacaga gggccaaaat tgaatgctat gcttagatta ggggttttgc     8580

aacctgaggt ctataaacaa agtcttcctg gaagtaattg taagcatcct gaaataaaaa     8640

agcaagaata tgaagaagta gttcagactg ttaatacaga tttctctcca tatctgattt     8700

cagataactt agaacagcct atgggaagta gtcatacatc tcaggtttgt tctgagacac     8760

ctgatgacct gttagatgat ggtgaaataa aggaagatac tagttttgct gaaaatgaca     8820

ttaaggaaag ttctgctgtt tttagcaaaa gcgtccagag aggagagctt agcaggagtc     8880

ctagcccttt cacccataca catttggctc agggttaccg aagaggggcc aagaaattag     8940

agtcctcaga agagaactta tctagtgagg atgaagagct tccctgcttc caacacttgt     9000

tatttggtaa agtaaacaat ataccttctc agtctactag gcatagcacc gttgctaccg     9060

agtgtctgtc taagaacaca gaggagaatt tattatcatt gaagaatagc ttaaatgact     9120

gcagtaacca ggtaatattg gcaaaggcat ctcaggaaca tcaccttagt gaggaaacaa     9180

aatgttctgc tagcttgttt tcttcacagt gcagtgaatt ggaagacttg actgcaaata     9240

caaacaccca ggatcctttc ttgattggtt cttccaaaca aatgaggcat cagtctgaaa     9300

gccagggagt tggtctgagt gacaaggaat tggtttcaga tgatgaagaa agaggaacgg     9360

gcttggaaga aaataatcaa gaagagcaaa gcatggattc aaacttaggt gaagcagcat     9420

ctgggtgtga gagtgaaaca agcgtctctg aagactgctc agggctatcc tctcagagtg     9480

acattttaac cactcagcag agggatacca tgcaacataa cctgataaag ctccagcagg     9540

aaatggctga actagaagct gtgttagaac agcatgggag ccagccttct aacagctacc     9600

ctagtataat cagtgactct tctgcccttg aggacctgcg aaatccagaa caaagcacat     9660

cagaaaaagc agtattaact tcacagaaaa gtagtgaata ccctataagc cagaatccag     9720

aaggcctttc tgctgacaag tttgaggtgt ctgcagatag ttctaccagt aaaaataaag     9780

aaccaggagt ggaaaggtca tccccttcta aatgcccatc attagatgat aggtggtaca     9840

tgcacagttg ctctgggagt cttcagaata gaaactaccc atctcaagag gagctcatta     9900

aggttgttga tgtggaggag caacagctgg aagagtctgg gccacacgat ttgacggaaa     9960

catcttactt gccaaggcaa gatctagagg gaacccctta cctggaatct ggaatcagcc    10020

tcttctctga tgaccctgaa tctgatcctt ctgaagacag agccccagag tcagctcgtg    10080

ttggcaacat accatcttca acctctgcat tgaaagttcc ccaattgaaa gttgcagaat    10140

ctgcccaggg tccagctgct gctcatacta ctgatactgc tgggtataat gcaatggaag    10200

aaagtgtgag cagggagaag ccagaattga cagcttcaac agaaagggtc aacaaaagaa    10260

tgtccatggt ggtgtctggc ctgaccccag aagaatttat gctcgtgtac aagtttgcca    10320

gaaaacacca catcacttta actaatctaa ttactgaaga gactactcat gttgttatga    10380

aaacagatgc tgagtttgtg tgtgaacgga cactgaaata ttttctagga attgcgggag    10440

gaaaatgggt agttagctat ttctgggtga cccagtctat taaagaaaga aaaatgctga    10500

atgagcatga ttttgaagtc agaggagatg tggtcaatgg aagaaaccac caaggtccaa    10560

agcgagcaag agaatcccag gacagaaaga tcttcagggg gctagaaatc tgttgctatg    10620

ggcccttcac caacatgccc acagatcaac tggaatggat ggtacagctg tgtggtgctt    10680

ctgtggtgaa ggagctttca tcattcaccc ttggcacagg tgtccaccca attgtggttg    10740

tgcagccaga tgcctggaca gaggacaatg gcttccatgc aattgggcag atgtgtgagg    10800

cacctgtggt gacccgagag tgggtgttgg acagtgtagc actctaccag tgccaggagc    10860

tggacaccta cctgataccc cagatccccc acagccacta catcgattga ttaattaaga    10920

attcgaccca gctttcttgt acaaagtggt tgatatccag cacagtggcg gccgctcgag    10980

tctagagggc ccgcggttcg aaggtaagcc tatccctaac cctctcctcg gtctcgattc    11040

tacgcgtacc ggttagcaat tgttttttcg atgagtttgg acaaaccaca actagaatgc    11100

agtgaaaaaa atgctttatt tgtgaaattt gtgatgctat tgctttattt gtaaccatta    11160

taagctgcaa taaacaagtt aacaacaaca attgcattca ttttatgttt caggttcagg    11220

gggaggtgtg ggaggttttt taaagcaagt aaaacctcta caaatgtggt acttaagagg    11280

gggagaccaa agggcgagac gttaaggcct cacgtgacat gtgagcaaaa ggccagcaaa    11340

aggccaggaa ccgtaaaaag gccgcgttgc tggcgttttt ccataggctc cgcccccctg    11400

acgagcatca caaaaatcga cgctcaagtc agaggtggcg aaacccgaca ggactataaa    11460

gataccaggc gtttccccct ggaagctccc tcgtgcgctc tcctgttccg accctgccgc    11520

ttaccggata cctgtccgcc tttctccctt cgggaagcgt ggcgctttct catagctcac    11580

gctgtaggta tctcagttcg gtgtaggtcg ttcgctccaa gctgggctgt gtgcacgaac    11640

cccccgttca gcccgaccgc tgcgccttat ccggtaacta tcgtcttgag tccaacccgg    11700

taagacacga cttatcgcca ctggcagcag ccactggtaa caggattagc agagcgaggt    11760

atgtaggcgg tgctacagag ttcttgaagt ggtggcctaa ctacggctac actagaagga    11820

cagtatttgg tatctgcgct ctgctgaagc cagttacctt cggaaaaaga gttggtagct    11880

cttgatccgg caaacaaacc acgctggtag cggtggtttt tttgtttgca agcagcagat    11940

tacgcgcaga aaaaaaggat ctcaagaaga tcctttgatc ttttctacgg ggtctgacgc    12000

tcagtggaac gaaaactcac gttaagggat tttggtcatg ccgtctcaga agaactcgtc    12060

aagaaggcga tagaaggcga tgcgctgcga atcgggagcg gcgataccgt aaagcacgag    12120

gaagcggtca gcccattcgc cgccaagctc ttcagcaata tcacgggtag ccaacgctat    12180

gtcctgatag cggtccgcca cacccagccg gccacagtcg atgaatccag aaaagcggcc    12240

attttccacc atgatattcg gcaagcaggc atcgccatgg gtcacgacga gatcctcgcc    12300

gtcgggcatg ctcgccttga gcctggcgaa cagttcggct ggcgcgagcc cctgatgctc    12360

ttcgtccaga tcatcctgat cgacaagacc ggcttccatc cgagtacgtg ctcgctcgat    12420

gcgatgtttc gcttggtggt cgaatgggca ggtagccgga tcaagcgtat gcagccgccg    12480

cattgcatca gccatgatgg atactttctc ggcaggagca aggtgagatg acaggagatc    12540

ctgccccggc acttcgccca atagcagcca gtcccttccc gcttcagtga caacgtcgag    12600

cacagctgcg caaggaacgc ccgtcgtggc cagccacgat agccgcgctg cctcgtcttg    12660

cagttcattc agggcaccgg acaggtcggt cttgacaaaa agaaccgggc gcccctgcgc    12720

tgacagccgg aacacggcgg catcagagca gccgattgtc tgttgtgccc agtcatagcc    12780

gaatagcctc tccacccaag cggccggaga acctgcgtgc aatccatctt gttcaatcat    12840

aatattattg aagcatttat cagggttcgt ctcgtcccgg tctcctccca tgcatg        12896


<210>  38
<211>  3300
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  38

Met Ile Asp Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
1               5                   10                  15      


Gly Ser Met Tyr Pro Tyr Asp Val Pro Asp Tyr Ala Ser Pro Lys Lys 
            20                  25                  30          


Lys Arg Lys Val Glu Ala Ser Asp Lys Lys Tyr Ser Ile Gly Leu Asp 
        35                  40                  45              


Ile Gly Thr Asn Ser Val Gly Trp Ala Val Ile Thr Asp Glu Tyr Lys 
    50                  55                  60                  


Val Pro Ser Lys Lys Phe Lys Val Leu Gly Asn Thr Asp Arg His Ser 
65                  70                  75                  80  


Ile Lys Lys Asn Leu Ile Gly Ala Leu Leu Phe Asp Ser Gly Glu Thr 
                85                  90                  95      


Ala Glu Ala Thr Arg Leu Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg 
            100                 105                 110         


Arg Lys Asn Arg Ile Cys Tyr Leu Gln Glu Ile Phe Ser Asn Glu Met 
        115                 120                 125             


Ala Lys Val Asp Asp Ser Phe Phe His Arg Leu Glu Glu Ser Phe Leu 
    130                 135                 140                 


Val Glu Glu Asp Lys Lys His Glu Arg His Pro Ile Phe Gly Asn Ile 
145                 150                 155                 160 


Val Asp Glu Val Ala Tyr His Glu Lys Tyr Pro Thr Ile Tyr His Leu 
                165                 170                 175     


Arg Lys Lys Leu Val Asp Ser Thr Asp Lys Ala Asp Leu Arg Leu Ile 
            180                 185                 190         


Tyr Leu Ala Leu Ala His Met Ile Lys Phe Arg Gly His Phe Leu Ile 
        195                 200                 205             


Glu Gly Asp Leu Asn Pro Asp Asn Ser Asp Val Asp Lys Leu Phe Ile 
    210                 215                 220                 


Gln Leu Val Gln Thr Tyr Asn Gln Leu Phe Glu Glu Asn Pro Ile Asn 
225                 230                 235                 240 


Ala Ser Gly Val Asp Ala Lys Ala Ile Leu Ser Ala Arg Leu Ser Lys 
                245                 250                 255     


Ser Arg Arg Leu Glu Asn Leu Ile Ala Gln Leu Pro Gly Glu Lys Lys 
            260                 265                 270         


Asn Gly Leu Phe Gly Asn Leu Ile Ala Leu Ser Leu Gly Leu Thr Pro 
        275                 280                 285             


Asn Phe Lys Ser Asn Phe Asp Leu Ala Glu Asp Ala Lys Leu Gln Leu 
    290                 295                 300                 


Ser Lys Asp Thr Tyr Asp Asp Asp Leu Asp Asn Leu Leu Ala Gln Ile 
305                 310                 315                 320 


Gly Asp Gln Tyr Ala Asp Leu Phe Leu Ala Ala Lys Asn Leu Ser Asp 
                325                 330                 335     


Ala Ile Leu Leu Ser Asp Ile Leu Arg Val Asn Thr Glu Ile Thr Lys 
            340                 345                 350         


Ala Pro Leu Ser Ala Ser Met Ile Lys Arg Tyr Asp Glu His His Gln 
        355                 360                 365             


Asp Leu Thr Leu Leu Lys Ala Leu Val Arg Gln Gln Leu Pro Glu Lys 
    370                 375                 380                 


Tyr Lys Glu Ile Phe Phe Asp Gln Ser Lys Asn Gly Tyr Ala Gly Tyr 
385                 390                 395                 400 


Ile Asp Gly Gly Ala Ser Gln Glu Glu Phe Tyr Lys Phe Ile Lys Pro 
                405                 410                 415     


Ile Leu Glu Lys Met Asp Gly Thr Glu Glu Leu Leu Val Lys Leu Asn 
            420                 425                 430         


Arg Glu Asp Leu Leu Arg Lys Gln Arg Thr Phe Asp Asn Gly Ser Ile 
        435                 440                 445             


Pro His Gln Ile His Leu Gly Glu Leu His Ala Ile Leu Arg Arg Gln 
    450                 455                 460                 


Glu Asp Phe Tyr Pro Phe Leu Lys Asp Asn Arg Glu Lys Ile Glu Lys 
465                 470                 475                 480 


Ile Leu Thr Phe Arg Ile Pro Tyr Tyr Val Gly Pro Leu Ala Arg Gly 
                485                 490                 495     


Asn Ser Arg Phe Ala Trp Met Thr Arg Lys Ser Glu Glu Thr Ile Thr 
            500                 505                 510         


Pro Trp Asn Phe Glu Glu Val Val Asp Lys Gly Ala Ser Ala Gln Ser 
        515                 520                 525             


Phe Ile Glu Arg Met Thr Asn Phe Asp Lys Asn Leu Pro Asn Glu Lys 
    530                 535                 540                 


Val Leu Pro Lys His Ser Leu Leu Tyr Glu Tyr Phe Thr Val Tyr Asn 
545                 550                 555                 560 


Glu Leu Thr Lys Val Lys Tyr Val Thr Glu Gly Met Arg Lys Pro Ala 
                565                 570                 575     


Phe Leu Ser Gly Glu Gln Lys Lys Ala Ile Val Asp Leu Leu Phe Lys 
            580                 585                 590         


Thr Asn Arg Lys Val Thr Val Lys Gln Leu Lys Glu Asp Tyr Phe Lys 
        595                 600                 605             


Lys Ile Glu Cys Phe Asp Ser Val Glu Ile Ser Gly Val Glu Asp Arg 
    610                 615                 620                 


Phe Asn Ala Ser Leu Gly Thr Tyr His Asp Leu Leu Lys Ile Ile Lys 
625                 630                 635                 640 


Asp Lys Asp Phe Leu Asp Asn Glu Glu Asn Glu Asp Ile Leu Glu Asp 
                645                 650                 655     


Ile Val Leu Thr Leu Thr Leu Phe Glu Asp Arg Glu Met Ile Glu Glu 
            660                 665                 670         


Arg Leu Lys Thr Tyr Ala His Leu Phe Asp Asp Lys Val Met Lys Gln 
        675                 680                 685             


Leu Lys Arg Arg Arg Tyr Thr Gly Trp Gly Arg Leu Ser Arg Lys Leu 
    690                 695                 700                 


Ile Asn Gly Ile Arg Asp Lys Gln Ser Gly Lys Thr Ile Leu Asp Phe 
705                 710                 715                 720 


Leu Lys Ser Asp Gly Phe Ala Asn Arg Asn Phe Met Gln Leu Ile His 
                725                 730                 735     


Asp Asp Ser Leu Thr Phe Lys Glu Asp Ile Gln Lys Ala Gln Val Ser 
            740                 745                 750         


Gly Gln Gly Asp Ser Leu His Glu His Ile Ala Asn Leu Ala Gly Ser 
        755                 760                 765             


Pro Ala Ile Lys Lys Gly Ile Leu Gln Thr Val Lys Val Val Asp Glu 
    770                 775                 780                 


Leu Val Lys Val Met Gly Arg His Lys Pro Glu Asn Ile Val Ile Glu 
785                 790                 795                 800 


Met Ala Arg Glu Asn Gln Thr Thr Gln Lys Gly Gln Lys Asn Ser Arg 
                805                 810                 815     


Glu Arg Met Lys Arg Ile Glu Glu Gly Ile Lys Glu Leu Gly Ser Gln 
            820                 825                 830         


Ile Leu Lys Glu His Pro Val Glu Asn Thr Gln Leu Gln Asn Glu Lys 
        835                 840                 845             


Leu Tyr Leu Tyr Tyr Leu Gln Asn Gly Arg Asp Met Tyr Val Asp Gln 
    850                 855                 860                 


Glu Leu Asp Ile Asn Arg Leu Ser Asp Tyr Asp Val Asp His Ile Val 
865                 870                 875                 880 


Pro Gln Ser Phe Leu Lys Asp Asp Ser Ile Asp Asn Lys Val Leu Thr 
                885                 890                 895     


Arg Ser Asp Lys Asn Arg Gly Lys Ser Asp Asn Val Pro Ser Glu Glu 
            900                 905                 910         


Val Val Lys Lys Met Lys Asn Tyr Trp Arg Gln Leu Leu Asn Ala Lys 
        915                 920                 925             


Leu Ile Thr Gln Arg Lys Phe Asp Asn Leu Thr Lys Ala Glu Arg Gly 
    930                 935                 940                 


Gly Leu Ser Glu Leu Asp Lys Ala Gly Phe Ile Lys Arg Gln Leu Val 
945                 950                 955                 960 


Glu Thr Arg Gln Ile Thr Lys His Val Ala Gln Ile Leu Asp Ser Arg 
                965                 970                 975     


Met Asn Thr Lys Tyr Asp Glu Asn Asp Lys Leu Ile Arg Glu Val Lys 
            980                 985                 990         


Val Ile Thr Leu Lys Ser Lys Leu  Val Ser Asp Phe Arg  Lys Asp Phe 
        995                 1000                 1005             


Gln Phe  Tyr Lys Val Arg Glu  Ile Asn Asn Tyr His  His Ala His 
    1010                 1015                 1020             


Asp Ala  Tyr Leu Asn Ala Val  Val Gly Thr Ala Leu  Ile Lys Lys 
    1025                 1030                 1035             


Tyr Pro  Lys Leu Glu Ser Glu  Phe Val Tyr Gly Asp  Tyr Lys Val 
    1040                 1045                 1050             


Tyr Asp  Val Arg Lys Met Ile  Ala Lys Ser Glu Gln  Glu Ile Gly 
    1055                 1060                 1065             


Lys Ala  Thr Ala Lys Tyr Phe  Phe Tyr Ser Asn Ile  Met Asn Phe 
    1070                 1075                 1080             


Phe Lys  Thr Glu Ile Thr Leu  Ala Asn Gly Glu Ile  Arg Lys Arg 
    1085                 1090                 1095             


Pro Leu  Ile Glu Thr Asn Gly  Glu Thr Gly Glu Ile  Val Trp Asp 
    1100                 1105                 1110             


Lys Gly  Arg Asp Phe Ala Thr  Val Arg Lys Val Leu  Ser Met Pro 
    1115                 1120                 1125             


Gln Val  Asn Ile Val Lys Lys  Thr Glu Val Gln Thr  Gly Gly Phe 
    1130                 1135                 1140             


Ser Lys  Glu Ser Ile Leu Pro  Lys Arg Asn Ser Asp  Lys Leu Ile 
    1145                 1150                 1155             


Ala Arg  Lys Lys Asp Trp Asp  Pro Lys Lys Tyr Gly  Gly Phe Asp 
    1160                 1165                 1170             


Ser Pro  Thr Val Ala Tyr Ser  Val Leu Val Val Ala  Lys Val Glu 
    1175                 1180                 1185             


Lys Gly  Lys Ser Lys Lys Leu  Lys Ser Val Lys Glu  Leu Leu Gly 
    1190                 1195                 1200             


Ile Thr  Ile Met Glu Arg Ser  Ser Phe Glu Lys Asn  Pro Ile Asp 
    1205                 1210                 1215             


Phe Leu  Glu Ala Lys Gly Tyr  Lys Glu Val Lys Lys  Asp Leu Ile 
    1220                 1225                 1230             


Ile Lys  Leu Pro Lys Tyr Ser  Leu Phe Glu Leu Glu  Asn Gly Arg 
    1235                 1240                 1245             


Lys Arg  Met Leu Ala Ser Ala  Gly Glu Leu Gln Lys  Gly Asn Glu 
    1250                 1255                 1260             


Leu Ala  Leu Pro Ser Lys Tyr  Val Asn Phe Leu Tyr  Leu Ala Ser 
    1265                 1270                 1275             


His Tyr  Glu Lys Leu Lys Gly  Ser Pro Glu Asp Asn  Glu Gln Lys 
    1280                 1285                 1290             


Gln Leu  Phe Val Glu Gln His  Lys His Tyr Leu Asp  Glu Ile Ile 
    1295                 1300                 1305             


Glu Gln  Ile Ser Glu Phe Ser  Lys Arg Val Ile Leu  Ala Asp Ala 
    1310                 1315                 1320             


Asn Leu  Asp Lys Val Leu Ser  Ala Tyr Asn Lys His  Arg Asp Lys 
    1325                 1330                 1335             


Pro Ile  Arg Glu Gln Ala Glu  Asn Ile Ile His Leu  Phe Thr Leu 
    1340                 1345                 1350             


Thr Asn  Leu Gly Ala Pro Ala  Ala Phe Lys Tyr Phe  Asp Thr Thr 
    1355                 1360                 1365             


Ile Asp  Arg Lys Arg Tyr Thr  Ser Thr Lys Glu Val  Leu Asp Ala 
    1370                 1375                 1380             


Thr Leu  Ile His Gln Ser Ile  Thr Gly Leu Tyr Glu  Thr Arg Ile 
    1385                 1390                 1395             


Asp Leu  Ser Gln Leu Gly Gly  Asp Ser Pro Lys Lys  Lys Arg Lys 
    1400                 1405                 1410             


Val Glu  Ala Ser Gly Gly Gly  Gly Ser Gly Gly Gly  Gly Ser Gly 
    1415                 1420                 1425             


Gly Gly  Gly Ser Gly Pro Ala  Met Asp Leu Ser Ala  Leu Arg Val 
    1430                 1435                 1440             


Glu Glu  Val Gln Asn Val Ile  Asn Ala Met Gln Lys  Ile Leu Glu 
    1445                 1450                 1455             


Cys Pro  Ile Cys Leu Glu Leu  Ile Lys Glu Pro Val  Ser Thr Lys 
    1460                 1465                 1470             


Cys Asp  His Ile Phe Cys Lys  Phe Cys Met Leu Lys  Leu Leu Asn 
    1475                 1480                 1485             


Gln Lys  Lys Gly Pro Ser Gln  Cys Pro Leu Cys Lys  Asn Asp Ile 
    1490                 1495                 1500             


Thr Lys  Arg Ser Leu Gln Glu  Ser Thr Arg Phe Ser  Gln Leu Val 
    1505                 1510                 1515             


Glu Glu  Leu Leu Lys Ile Ile  Cys Ala Phe Gln Leu  Asp Thr Gly 
    1520                 1525                 1530             


Leu Glu  Tyr Ala Asn Ser Tyr  Asn Phe Ala Lys Lys  Glu Asn Asn 
    1535                 1540                 1545             


Ser Pro  Glu His Leu Lys Asp  Glu Val Ser Ile Ile  Gln Ser Met 
    1550                 1555                 1560             


Gly Tyr  Arg Asn Arg Ala Lys  Arg Leu Leu Gln Ser  Glu Pro Glu 
    1565                 1570                 1575             


Asn Pro  Ser Leu Gln Glu Thr  Ser Leu Ser Val Gln  Leu Ser Asn 
    1580                 1585                 1590             


Leu Gly  Thr Val Arg Thr Leu  Arg Thr Lys Gln Arg  Ile Gln Pro 
    1595                 1600                 1605             


Gln Lys  Thr Ser Val Tyr Ile  Glu Leu Gly Ser Asp  Ser Ser Glu 
    1610                 1615                 1620             


Asp Thr  Val Asn Lys Ala Thr  Tyr Cys Ser Val Gly  Asp Gln Glu 
    1625                 1630                 1635             


Leu Leu  Gln Ile Thr Pro Gln  Gly Thr Arg Asp Glu  Ile Ser Leu 
    1640                 1645                 1650             


Asp Ser  Ala Lys Lys Ala Ala  Cys Glu Phe Ser Glu  Thr Asp Val 
    1655                 1660                 1665             


Thr Asn  Thr Glu His His Gln  Pro Ser Asn Asn Asp  Leu Asn Thr 
    1670                 1675                 1680             


Thr Glu  Lys Arg Ala Ala Glu  Arg His Pro Glu Lys  Tyr Gln Gly 
    1685                 1690                 1695             


Ser Ser  Val Ser Asn Leu His  Val Glu Pro Cys Gly  Thr Asn Thr 
    1700                 1705                 1710             


His Ala  Ser Ser Leu Gln His  Glu Asn Ser Ser Leu  Leu Leu Thr 
    1715                 1720                 1725             


Lys Asp  Arg Met Asn Val Glu  Lys Ala Glu Phe Cys  Asn Lys Ser 
    1730                 1735                 1740             


Lys Gln  Pro Gly Leu Ala Arg  Ser Gln His Asn Arg  Trp Ala Gly 
    1745                 1750                 1755             


Ser Lys  Glu Thr Cys Asn Asp  Arg Arg Thr Pro Ser  Thr Glu Lys 
    1760                 1765                 1770             


Lys Val  Asp Leu Asn Ala Asp  Pro Leu Cys Glu Arg  Lys Glu Trp 
    1775                 1780                 1785             


Asn Lys  Gln Lys Leu Pro Cys  Ser Glu Asn Pro Arg  Asp Thr Glu 
    1790                 1795                 1800             


Asp Val  Pro Trp Ile Thr Leu  Asn Ser Ser Ile Gln  Lys Val Asn 
    1805                 1810                 1815             


Glu Trp  Phe Ser Arg Ser Asp  Glu Leu Leu Gly Ser  Asp Asp Ser 
    1820                 1825                 1830             


His Asp  Gly Glu Ser Glu Ser  Asn Ala Lys Val Ala  Asp Val Leu 
    1835                 1840                 1845             


Asp Val  Leu Asn Glu Val Asp  Glu Tyr Ser Gly Ser  Ser Glu Lys 
    1850                 1855                 1860             


Ile Asp  Leu Leu Ala Ser Asp  Pro His Glu Ala Leu  Ile Cys Lys 
    1865                 1870                 1875             


Ser Glu  Arg Val His Ser Lys  Ser Val Glu Ser Asn  Ile Glu Asp 
    1880                 1885                 1890             


Lys Ile  Phe Gly Lys Thr Tyr  Arg Lys Lys Ala Ser  Leu Pro Asn 
    1895                 1900                 1905             


Leu Ser  His Val Thr Glu Asn  Leu Ile Ile Gly Ala  Phe Val Thr 
    1910                 1915                 1920             


Glu Pro  Gln Ile Ile Gln Glu  Arg Pro Leu Thr Asn  Lys Leu Lys 
    1925                 1930                 1935             


Arg Lys  Arg Arg Pro Thr Ser  Gly Leu His Pro Glu  Asp Phe Ile 
    1940                 1945                 1950             


Lys Lys  Ala Asp Leu Ala Val  Gln Lys Thr Pro Glu  Met Ile Asn 
    1955                 1960                 1965             


Gln Gly  Thr Asn Gln Thr Glu  Gln Asn Gly Gln Val  Met Asn Ile 
    1970                 1975                 1980             


Thr Asn  Ser Gly His Glu Asn  Lys Thr Lys Gly Asp  Ser Ile Gln 
    1985                 1990                 1995             


Asn Glu  Lys Asn Pro Asn Pro  Ile Glu Ser Leu Glu  Lys Glu Ser 
    2000                 2005                 2010             


Ala Phe  Lys Thr Lys Ala Glu  Pro Ile Ser Ser Ser  Ile Ser Asn 
    2015                 2020                 2025             


Met Glu  Leu Glu Leu Asn Ile  His Asn Ser Lys Ala  Pro Lys Lys 
    2030                 2035                 2040             


Asn Arg  Leu Arg Arg Lys Ser  Ser Thr Arg His Ile  His Ala Leu 
    2045                 2050                 2055             


Glu Leu  Val Val Ser Arg Asn  Leu Ser Pro Pro Asn  Cys Thr Glu 
    2060                 2065                 2070             


Leu Gln  Ile Asp Ser Cys Ser  Ser Ser Glu Glu Ile  Lys Lys Lys 
    2075                 2080                 2085             


Lys Tyr  Asn Gln Met Pro Val  Arg His Ser Arg Asn  Leu Gln Leu 
    2090                 2095                 2100             


Met Glu  Gly Lys Glu Pro Ala  Thr Gly Ala Lys Lys  Ser Asn Lys 
    2105                 2110                 2115             


Pro Asn  Glu Gln Thr Ser Lys  Arg His Asp Ser Asp  Thr Phe Pro 
    2120                 2125                 2130             


Glu Leu  Lys Leu Thr Asn Ala  Pro Gly Ser Phe Thr  Lys Cys Ser 
    2135                 2140                 2145             


Asn Thr  Ser Glu Leu Lys Glu  Phe Val Asn Pro Ser  Leu Pro Arg 
    2150                 2155                 2160             


Glu Glu  Lys Glu Glu Lys Leu  Glu Thr Val Lys Val  Ser Asn Asn 
    2165                 2170                 2175             


Ala Glu  Asp Pro Lys Asp Leu  Met Leu Ser Gly Glu  Arg Val Leu 
    2180                 2185                 2190             


Gln Thr  Glu Arg Ser Val Glu  Ser Ser Ser Ile Ser  Leu Val Pro 
    2195                 2200                 2205             


Gly Thr  Asp Tyr Gly Thr Gln  Glu Ser Ile Ser Leu  Leu Glu Val 
    2210                 2215                 2220             


Ser Thr  Leu Gly Lys Ala Lys  Thr Glu Pro Asn Lys  Cys Val Ser 
    2225                 2230                 2235             


Gln Cys  Ala Ala Phe Glu Asn  Pro Lys Gly Leu Ile  His Gly Cys 
    2240                 2245                 2250             


Ser Lys  Asp Asn Arg Asn Asp  Thr Glu Gly Phe Lys  Tyr Pro Leu 
    2255                 2260                 2265             


Gly His  Glu Val Asn His Ser  Arg Glu Thr Ser Ile  Glu Met Glu 
    2270                 2275                 2280             


Glu Ser  Glu Leu Asp Ala Gln  Tyr Leu Gln Asn Thr  Phe Lys Val 
    2285                 2290                 2295             


Ser Lys  Arg Gln Ser Phe Ala  Leu Phe Ser Asn Pro  Gly Asn Ala 
    2300                 2305                 2310             


Glu Glu  Glu Cys Ala Thr Phe  Ser Ala His Ser Gly  Ser Leu Lys 
    2315                 2320                 2325             


Lys Gln  Ser Pro Lys Val Thr  Phe Glu Cys Glu Gln  Lys Glu Glu 
    2330                 2335                 2340             


Asn Gln  Gly Lys Asn Glu Ser  Asn Ile Lys Pro Val  Gln Thr Val 
    2345                 2350                 2355             


Asn Ile  Thr Ala Gly Phe Pro  Val Val Gly Gln Lys  Asp Lys Pro 
    2360                 2365                 2370             


Val Asp  Asn Ala Lys Cys Ser  Ile Lys Gly Gly Ser  Arg Phe Cys 
    2375                 2380                 2385             


Leu Ser  Ser Gln Phe Arg Gly  Asn Glu Thr Gly Leu  Ile Thr Pro 
    2390                 2395                 2400             


Asn Lys  His Gly Leu Leu Gln  Asn Pro Tyr Arg Ile  Pro Pro Leu 
    2405                 2410                 2415             


Phe Pro  Ile Lys Ser Phe Val  Lys Thr Lys Cys Lys  Lys Asn Leu 
    2420                 2425                 2430             


Leu Glu  Glu Asn Phe Glu Glu  His Ser Met Ser Pro  Glu Arg Glu 
    2435                 2440                 2445             


Met Gly  Asn Glu Asn Ile Pro  Ser Thr Val Ser Thr  Ile Ser Arg 
    2450                 2455                 2460             


Asn Asn  Ile Arg Glu Asn Val  Phe Lys Gly Ala Ser  Ser Ser Asn 
    2465                 2470                 2475             


Ile Asn  Glu Val Gly Ser Ser  Thr Asn Glu Val Gly  Ser Ser Ile 
    2480                 2485                 2490             


Asn Glu  Ile Gly Ser Ser Asp  Glu Asn Ile Gln Ala  Glu Leu Gly 
    2495                 2500                 2505             


Arg Asn  Arg Gly Pro Lys Leu  Asn Ala Met Leu Arg  Leu Gly Val 
    2510                 2515                 2520             


Leu Gln  Pro Glu Val Tyr Lys  Gln Ser Leu Pro Gly  Ser Asn Cys 
    2525                 2530                 2535             


Lys His  Pro Glu Ile Lys Lys  Gln Glu Tyr Glu Glu  Val Val Gln 
    2540                 2545                 2550             


Thr Val  Asn Thr Asp Phe Ser  Pro Tyr Leu Ile Ser  Asp Asn Leu 
    2555                 2560                 2565             


Glu Gln  Pro Met Gly Ser Ser  His Thr Ser Gln Val  Cys Ser Glu 
    2570                 2575                 2580             


Thr Pro  Asp Asp Leu Leu Asp  Asp Gly Glu Ile Lys  Glu Asp Thr 
    2585                 2590                 2595             


Ser Phe  Ala Glu Asn Asp Ile  Lys Glu Ser Ser Ala  Val Phe Ser 
    2600                 2605                 2610             


Lys Ser  Val Gln Arg Gly Glu  Leu Ser Arg Ser Pro  Ser Pro Phe 
    2615                 2620                 2625             


Thr His  Thr His Leu Ala Gln  Gly Tyr Arg Arg Gly  Ala Lys Lys 
    2630                 2635                 2640             


Leu Glu  Ser Ser Glu Glu Asn  Leu Ser Ser Glu Asp  Glu Glu Leu 
    2645                 2650                 2655             


Pro Cys  Phe Gln His Leu Leu  Phe Gly Lys Val Asn  Asn Ile Pro 
    2660                 2665                 2670             


Ser Gln  Ser Thr Arg His Ser  Thr Val Ala Thr Glu  Cys Leu Ser 
    2675                 2680                 2685             


Lys Asn  Thr Glu Glu Asn Leu  Leu Ser Leu Lys Asn  Ser Leu Asn 
    2690                 2695                 2700             


Asp Cys  Ser Asn Gln Val Ile  Leu Ala Lys Ala Ser  Gln Glu His 
    2705                 2710                 2715             


His Leu  Ser Glu Glu Thr Lys  Cys Ser Ala Ser Leu  Phe Ser Ser 
    2720                 2725                 2730             


Gln Cys  Ser Glu Leu Glu Asp  Leu Thr Ala Asn Thr  Asn Thr Gln 
    2735                 2740                 2745             


Asp Pro  Phe Leu Ile Gly Ser  Ser Lys Gln Met Arg  His Gln Ser 
    2750                 2755                 2760             


Glu Ser  Gln Gly Val Gly Leu  Ser Asp Lys Glu Leu  Val Ser Asp 
    2765                 2770                 2775             


Asp Glu  Glu Arg Gly Thr Gly  Leu Glu Glu Asn Asn  Gln Glu Glu 
    2780                 2785                 2790             


Gln Ser  Met Asp Ser Asn Leu  Gly Glu Ala Ala Ser  Gly Cys Glu 
    2795                 2800                 2805             


Ser Glu  Thr Ser Val Ser Glu  Asp Cys Ser Gly Leu  Ser Ser Gln 
    2810                 2815                 2820             


Ser Asp  Ile Leu Thr Thr Gln  Gln Arg Asp Thr Met  Gln His Asn 
    2825                 2830                 2835             


Leu Ile  Lys Leu Gln Gln Glu  Met Ala Glu Leu Glu  Ala Val Leu 
    2840                 2845                 2850             


Glu Gln  His Gly Ser Gln Pro  Ser Asn Ser Tyr Pro  Ser Ile Ile 
    2855                 2860                 2865             


Ser Asp  Ser Ser Ala Leu Glu  Asp Leu Arg Asn Pro  Glu Gln Ser 
    2870                 2875                 2880             


Thr Ser  Glu Lys Ala Val Leu  Thr Ser Gln Lys Ser  Ser Glu Tyr 
    2885                 2890                 2895             


Pro Ile  Ser Gln Asn Pro Glu  Gly Leu Ser Ala Asp  Lys Phe Glu 
    2900                 2905                 2910             


Val Ser  Ala Asp Ser Ser Thr  Ser Lys Asn Lys Glu  Pro Gly Val 
    2915                 2920                 2925             


Glu Arg  Ser Ser Pro Ser Lys  Cys Pro Ser Leu Asp  Asp Arg Trp 
    2930                 2935                 2940             


Tyr Met  His Ser Cys Ser Gly  Ser Leu Gln Asn Arg  Asn Tyr Pro 
    2945                 2950                 2955             


Ser Gln  Glu Glu Leu Ile Lys  Val Val Asp Val Glu  Glu Gln Gln 
    2960                 2965                 2970             


Leu Glu  Glu Ser Gly Pro His  Asp Leu Thr Glu Thr  Ser Tyr Leu 
    2975                 2980                 2985             


Pro Arg  Gln Asp Leu Glu Gly  Thr Pro Tyr Leu Glu  Ser Gly Ile 
    2990                 2995                 3000             


Ser Leu  Phe Ser Asp Asp Pro  Glu Ser Asp Pro Ser  Glu Asp Arg 
    3005                 3010                 3015             


Ala Pro  Glu Ser Ala Arg Val  Gly Asn Ile Pro Ser  Ser Thr Ser 
    3020                 3025                 3030             


Ala Leu  Lys Val Pro Gln Leu  Lys Val Ala Glu Ser  Ala Gln Gly 
    3035                 3040                 3045             


Pro Ala  Ala Ala His Thr Thr  Asp Thr Ala Gly Tyr  Asn Ala Met 
    3050                 3055                 3060             


Glu Glu  Ser Val Ser Arg Glu  Lys Pro Glu Leu Thr  Ala Ser Thr 
    3065                 3070                 3075             


Glu Arg  Val Asn Lys Arg Met  Ser Met Val Val Ser  Gly Leu Thr 
    3080                 3085                 3090             


Pro Glu  Glu Phe Met Leu Val  Tyr Lys Phe Ala Arg  Lys His His 
    3095                 3100                 3105             


Ile Thr  Leu Thr Asn Leu Ile  Thr Glu Glu Thr Thr  His Val Val 
    3110                 3115                 3120             


Met Lys  Thr Asp Ala Glu Phe  Val Cys Glu Arg Thr  Leu Lys Tyr 
    3125                 3130                 3135             


Phe Leu  Gly Ile Ala Gly Gly  Lys Trp Val Val Ser  Tyr Phe Trp 
    3140                 3145                 3150             


Val Thr  Gln Ser Ile Lys Glu  Arg Lys Met Leu Asn  Glu His Asp 
    3155                 3160                 3165             


Phe Glu  Val Arg Gly Asp Val  Val Asn Gly Arg Asn  His Gln Gly 
    3170                 3175                 3180             


Pro Lys  Arg Ala Arg Glu Ser  Gln Asp Arg Lys Ile  Phe Arg Gly 
    3185                 3190                 3195             


Leu Glu  Ile Cys Cys Tyr Gly  Pro Phe Thr Asn Met  Pro Thr Asp 
    3200                 3205                 3210             


Gln Leu  Glu Trp Met Val Gln  Leu Cys Gly Ala Ser  Val Val Lys 
    3215                 3220                 3225             


Glu Leu  Ser Ser Phe Thr Leu  Gly Thr Gly Val His  Pro Ile Val 
    3230                 3235                 3240             


Val Val  Gln Pro Asp Ala Trp  Thr Glu Asp Asn Gly  Phe His Ala 
    3245                 3250                 3255             


Ile Gly  Gln Met Cys Glu Ala  Pro Val Val Thr Arg  Glu Trp Val 
    3260                 3265                 3270             


Leu Asp  Ser Val Ala Leu Tyr  Gln Cys Gln Glu Leu  Asp Thr Tyr 
    3275                 3280                 3285             


Leu Ile  Pro Gln Ile Pro His  Ser His Tyr Ile Asp  
    3290                 3295                 3300 


<210>  39
<211>  9965
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide

<400>  39
tcaatattgg ccattagcca tattattcat tggttatata gcataaatca atattggcta       60

ttggccattg catacgttgt atctatatca taatatgtac atttatattg gctcatgtcc      120

aatatgaccg ccatgttggc attgattatt gactagttat taatagtaat caattacggg      180

gtcattagtt catagcccat atatggagtt ccgcgttaca taacttacgg taaatggccc      240

gcctggctga ccgcccaacg acccccgccc attgacgtca ataatgacgt atgttcccat      300

agtaacgcca atagggactt tccattgacg tcaatgggtg gagtatttac ggtaaactgc      360

ccacttggca gtacatcaag tgtatcatat gccaagtccg ccccctattg acgtcaatga      420

cggtaaatgg cccgcctggc attatgccca gtacatgacc ttacgggact ttcctacttg      480

gcagtacatc tacgtattag tcatcgctat taccatggtg atgcggtttt ggcagtacac      540

caatgggcgt ggatagcggt ttgactcacg gggatttcca agtctccacc ccattgacgt      600

caatgggagt ttgttttggc accaaaatca acgggacttt ccaaaatgtc gtaataaccc      660

cgccccgttg acgcaaatgg gcggtaggcg tgtacggtgg gaggtctata taagcagagg      720

tcgtttagtg aaccgtcaga tcactagtag ctttattgcg gtagtttatc acagttaaat      780

tgctaacgca gtcagtgctc gactgatcac aggtaagtat caaggttaca agacaggttt      840

aaggaggcca atagaaactg ggcttgtcga gacagagaag attcttgcgt ttctgatagg      900

cacctattgg tcttactgac atccactttg cctttctctc cacagggaaa aaacaattga      960

caagtttgta caaaaaagca ggctccgaat tcaccggtgc cgccaccatg gggccggcca     1020

tggatttatc tgctcttcgc gttgaagaag tacaaaatgt cattaatgct atgcagaaaa     1080

tcttagagtg tcccatctgt ctggagttga tcaaggaacc tgtctccaca aagtgtgacc     1140

acatattttg caaattttgc atgctgaaac ttctcaacca gaagaaaggg ccttcacagt     1200

gtcctttatg taagaatgat ataaccaaaa ggagcctaca agaaagtacg agatttagtc     1260

aacttgttga agagctattg aaaatcattt gtgcttttca gcttgacaca ggtttggagt     1320

atgcaaacag ctataatttt gcaaaaaagg aaaataactc tcctgaacat ctaaaagatg     1380

aagtttctat catccaaagt atgggctaca gaaaccgtgc caaaagactt ctacagagtg     1440

aacccgaaaa tccttccttg caggaaacca gtctcagtgt ccaactctct aaccttggaa     1500

ctgtgagaac tctgaggaca aagcagcgga tacaacctca aaagacgtct gtctacattg     1560

aattgggatc tgattcttct gaagataccg ttaataaggc aacttattgc agtgtgggag     1620

atcaagaatt gttacaaatc acccctcaag gaaccaggga tgaaatcagt ttggattctg     1680

caaaaaaggc tgcttgtgaa ttttctgaga cggatgtaac aaatactgaa catcatcaac     1740

ccagtaataa tgatttgaac accactgaga agcgtgcagc tgagaggcat ccagaaaagt     1800

atcagggtag ttctgtttca aacttgcatg tggagccatg tggcacaaat actcatgcca     1860

gctcattaca gcatgagaac agcagtttat tactcactaa agacagaatg aatgtagaaa     1920

aggctgaatt ctgtaataaa agcaaacagc ctggcttagc aaggagccaa cataacagat     1980

gggctggaag taaggaaaca tgtaatgata ggcggactcc cagcacagaa aaaaaggtag     2040

atctgaatgc tgatcccctg tgtgagagaa aagaatggaa taagcagaaa ctgccatgct     2100

cagagaatcc tagagatact gaagatgttc cttggataac actaaatagc agcattcaga     2160

aagttaatga gtggttttcc agaagtgatg aactgttagg ttctgatgac tcacatgatg     2220

gggagtctga atcaaatgcc aaagtagctg atgtattgga cgttctaaat gaggtagatg     2280

aatattctgg ttcttcagag aaaatagact tactggccag tgatcctcat gaggctttaa     2340

tatgtaaaag tgaaagagtt cactccaaat cagtagagag taatattgaa gacaaaatat     2400

ttgggaaaac ctatcggaag aaggcaagcc tccccaactt aagccatgta actgaaaatc     2460

taattatagg agcatttgtt actgagccac agataataca agagcgtccc ctcacaaata     2520

aattaaagcg taaaaggaga cctacatcag gccttcatcc tgaggatttt atcaagaaag     2580

cagatttggc agttcaaaag actcctgaaa tgataaatca gggaactaac caaacggagc     2640

agaatggtca agtgatgaat attactaata gtggtcatga gaataaaaca aaaggtgatt     2700

ctattcagaa tgagaaaaat cctaacccaa tagaatcact cgaaaaagaa tctgctttca     2760

aaacgaaagc tgaacctata agcagcagta taagcaatat ggaactcgaa ttaaatatcc     2820

acaattcaaa agcacctaaa aagaataggc tgaggaggaa gtcttctacc aggcatattc     2880

atgcgcttga actagtagtc agtagaaatc taagcccacc taattgtact gaattgcaaa     2940

ttgatagttg ttctagcagt gaagagataa agaaaaaaaa gtacaaccaa atgccagtca     3000

ggcacagcag aaacctacaa ctcatggaag gtaaagaacc tgcaactgga gccaagaaga     3060

gtaacaagcc aaatgaacag acaagtaaaa gacatgacag tgatactttc ccagagctga     3120

agttaacaaa tgcacctggt tcttttacta agtgttcaaa taccagtgaa cttaaagaat     3180

ttgtcaatcc tagccttcca agagaagaaa aagaagagaa actagaaaca gttaaagtgt     3240

ctaataatgc tgaagacccc aaagatctca tgttaagtgg agaaagggtt ttgcaaactg     3300

aaagatctgt agagagtagc agtatttcac tggtacctgg tactgattat ggcactcagg     3360

aaagtatctc gttactggaa gttagcactc tagggaaggc aaaaacagaa ccaaataaat     3420

gtgtgagtca gtgtgcagca tttgaaaacc ccaagggact aattcatggt tgttccaaag     3480

ataatagaaa tgacacagaa ggctttaagt atccattggg acatgaagtt aaccacagtc     3540

gggaaacaag catagaaatg gaagaaagtg aacttgatgc tcagtatttg cagaatacat     3600

tcaaggtttc aaagcgccag tcatttgctc tgttttcaaa tccaggaaat gcagaagagg     3660

aatgtgcaac attctctgcc cactctgggt ccttaaagaa acaaagtcca aaagtcactt     3720

ttgaatgtga acaaaaggaa gaaaatcaag gaaagaatga gtctaatatc aagcctgtac     3780

agacagttaa tatcactgca ggctttcctg tggttggtca gaaagataag ccagttgata     3840

atgccaaatg tagtatcaaa ggaggctcta ggttttgtct atcatctcag ttcagaggca     3900

acgaaactgg actcattact ccaaataaac atggactttt acaaaaccca tatcgtatac     3960

caccactttt tcccatcaag tcatttgtta aaactaaatg taagaaaaat ctgctagagg     4020

aaaactttga ggaacattca atgtcacctg aaagagaaat gggaaatgag aacattccaa     4080

gtacagtgag cacaattagc cgtaataaca ttagagaaaa tgtttttaaa ggagccagct     4140

caagcaatat taatgaagta ggttccagta ctaatgaagt gggctccagt attaatgaaa     4200

taggttccag tgatgaaaac attcaagcag aactaggtag aaacagaggg ccaaaattga     4260

atgctatgct tagattaggg gttttgcaac ctgaggtcta taaacaaagt cttcctggaa     4320

gtaattgtaa gcatcctgaa ataaaaaagc aagaatatga agaagtagtt cagactgtta     4380

atacagattt ctctccatat ctgatttcag ataacttaga acagcctatg ggaagtagtc     4440

atacatctca ggtttgttct gagacacctg atgacctgtt agatgatggt gaaataaagg     4500

aagatactag ttttgctgaa aatgacatta aggaaagttc tgctgttttt agcaaaagcg     4560

tccagagagg agagcttagc aggagtccta gccctttcac ccatacacat ttggctcagg     4620

gttaccgaag aggggccaag aaattagagt cctcagaaga gaacttatct agtgaggatg     4680

aagagcttcc ctgcttccaa cacttgttat ttggtaaagt aaacaatata ccttctcagt     4740

ctactaggca tagcaccgtt gctaccgagt gtctgtctaa gaacacagag gagaatttat     4800

tatcattgaa gaatagctta aatgactgca gtaaccaggt aatattggca aaggcatctc     4860

aggaacatca ccttagtgag gaaacaaaat gttctgctag cttgttttct tcacagtgca     4920

gtgaattgga agacttgact gcaaatacaa acacccagga tcctttcttg attggttctt     4980

ccaaacaaat gaggcatcag tctgaaagcc agggagttgg tctgagtgac aaggaattgg     5040

tttcagatga tgaagaaaga ggaacgggct tggaagaaaa taatcaagaa gagcaaagca     5100

tggattcaaa cttaggtgaa gcagcatctg ggtgtgagag tgaaacaagc gtctctgaag     5160

actgctcagg gctatcctct cagagtgaca ttttaaccac tcagcagagg gataccatgc     5220

aacataacct gataaagctc cagcaggaaa tggctgaact agaagctgtg ttagaacagc     5280

atgggagcca gccttctaac agctacccta gtataatcag tgactcttct gcccttgagg     5340

acctgcgaaa tccagaacaa agcacatcag aaaaagcagt attaacttca cagaaaagta     5400

gtgaataccc tataagccag aatccagaag gcctttctgc tgacaagttt gaggtgtctg     5460

cagatagttc taccagtaaa aataaagaac caggagtgga aaggtcatcc ccttctaaat     5520

gcccatcatt agatgatagg tggtacatgc acagttgctc tgggagtctt cagaatagaa     5580

actacccatc tcaagaggag ctcattaagg ttgttgatgt ggaggagcaa cagctggaag     5640

agtctgggcc acacgatttg acggaaacat cttacttgcc aaggcaagat ctagagggaa     5700

ccccttacct ggaatctgga atcagcctct tctctgatga ccctgaatct gatccttctg     5760

aagacagagc cccagagtca gctcgtgttg gcaacatacc atcttcaacc tctgcattga     5820

aagttcccca attgaaagtt gcagaatctg cccagggtcc agctgctgct catactactg     5880

atactgctgg gtataatgca atggaagaaa gtgtgagcag ggagaagcca gaattgacag     5940

cttcaacaga aagggtcaac aaaagaatgt ccatggtggt gtctggcctg accccagaag     6000

aatttatgct cgtgtacaag tttgccagaa aacaccacat cactttaact aatctaatta     6060

ctgaagagac tactcatgtt gttatgaaaa cagatgctga gtttgtgtgt gaacggacac     6120

tgaaatattt tctaggaatt gcgggaggaa aatgggtagt tagctatttc tgggtgaccc     6180

agtctattaa agaaagaaaa atgctgaatg agcatgattt tgaagtcaga ggagatgtgg     6240

tcaatggaag aaaccaccaa ggtccaaagc gagcaagaga atcccaggac agaaagatct     6300

tcagggggct agaaatctgt tgctatgggc ccttcaccaa catgcccaca gatcaactgg     6360

aatggatggt acagctgtgt ggtgcttctg tggtgaagga gctttcatca ttcacccttg     6420

gcacaggtgt ccacccaatt gtggttgtgc agccagatgc ctggacagag gacaatggct     6480

tccatgcaat tgggcagatg tgtgaggcac ctgtggtgac ccgagagtgg gtgttggaca     6540

gtgtagcact ctaccagtgc caggagctgg acacctacct gataccccag atcccccaca     6600

gccactacat cgatggcgga ggcggatctg atccaaaaaa gaagagaaag gtagatccaa     6660

aaaagaagag aaaggtagat ccaaaaaaga agagaaaggt aggatctacc ggatctagaa     6720

acgatggtgg tggtggaagc gggggtgggg gcagcggtgg agggggaagc gggcgcgccg     6780

ggatcctccc ccccaagaaa aagaggaagg tatctagagg ccgcagccgc cttttggaag     6840

attttcgaaa caaccggtac cccaatttac aactgcggga gattgctgga catataatgg     6900

aattttccca agaccagcat gggtccagat tcattcagct gaaactggag cgtgccacac     6960

cagctgagcg ccagcttgtc ttcaatgaaa tcctccaggc tgcctaccaa ctcatggtgg     7020

atgtgtttgg taattacgtc attcagaagt tctttgaatt tggcagtctt gaacagaagc     7080

tggctttggc agaacggatt cgaggccacg tcctgtcatt ggcactacag atgtatggca     7140

gccgtgttat cgagaaagct cttgagttta ttccttcaga ccagcagaat gagatggttc     7200

gggaactaga tggccatgtc ttgaagtgtg tgaaagatca gaatggcaat cacgtggttc     7260

agaaatgcat tgaatgtgta cagccccagt ctttgcaatt tatcatcgac gcgtttaagg     7320

gacaggtatt tgccttatcc acacatcctt atggctgccg agtgattcag agaatcctgg     7380

agcactgtct ccctgaccag acactcccta ttttagagga gcttcaccag cacacagagc     7440

agctggtaca ggatcaatat ggaaattatg taatccaaca tgtactggag cacggtcgtc     7500

ctgaggataa aagcaaaatt gtagcagaaa tccgaggcaa tgtacttgta ttgagtcagc     7560

acaaatttgc aagcaatgtt gtggagaagt gtgttactca cgcctcacgt acggagcgcg     7620

ctgtgctcat cgacgaggtg tgcaccatga acgacggtcc ccacagtgcc ttatacacca     7680

tgatgaagga ccagtatgcc aactacgtgg tccagaagat gattgacgtg gcggagccag     7740

gccagcggaa gatcgtcatg cataagatcc ggccccacat cgcaactctt cgtaagtaca     7800

cctatggcaa gcacattctg gccaagctgg agaagtacta catgaagaac ggtgttgact     7860

taggggaccc aaagaagaag cgcaaagtgg atcctaaaaa gaaaagaaag gtaggcggcc     7920

gcgggggagg cggttccggt ggcggcggaa gcggaggtgg aggatcaggg ccggcctgat     7980

taattaagaa ttcgacccag ctttcttgta caaagtggtt gatatccagc acagtggcgg     8040

ccgctcgagt ctagagggcc cgcggttcga aggtaagcct atccctaacc ctctcctcgg     8100

tctcgattct acgcgtaccg gttagcaatt gttttttcga tgagtttgga caaaccacaa     8160

ctagaatgca gtgaaaaaaa tgctttattt gtgaaatttg tgatgctatt gctttatttg     8220

taaccattat aagctgcaat aaacaagtta acaacaacaa ttgcattcat tttatgtttc     8280

aggttcaggg ggaggtgtgg gaggtttttt aaagcaagta aaacctctac aaatgtggta     8340

cttaagaggg ggagaccaaa gggcgagacg ttaaggcctc acgtgacatg tgagcaaaag     8400

gccagcaaaa ggccaggaac cgtaaaaagg ccgcgttgct ggcgtttttc cataggctcc     8460

gcccccctga cgagcatcac aaaaatcgac gctcaagtca gaggtggcga aacccgacag     8520

gactataaag ataccaggcg tttccccctg gaagctccct cgtgcgctct cctgttccga     8580

ccctgccgct taccggatac ctgtccgcct ttctcccttc gggaagcgtg gcgctttctc     8640

atagctcacg ctgtaggtat ctcagttcgg tgtaggtcgt tcgctccaag ctgggctgtg     8700

tgcacgaacc ccccgttcag cccgaccgct gcgccttatc cggtaactat cgtcttgagt     8760

ccaacccggt aagacacgac ttatcgccac tggcagcagc cactggtaac aggattagca     8820

gagcgaggta tgtaggcggt gctacagagt tcttgaagtg gtggcctaac tacggctaca     8880

ctagaaggac agtatttggt atctgcgctc tgctgaagcc agttaccttc ggaaaaagag     8940

ttggtagctc ttgatccggc aaacaaacca cgctggtagc ggtggttttt ttgtttgcaa     9000

gcagcagatt acgcgcagaa aaaaaggatc tcaagaagat cctttgatct tttctacggg     9060

gtctgacgct cagtggaacg aaaactcacg ttaagggatt ttggtcatgc cgtctcagaa     9120

gaactcgtca agaaggcgat agaaggcgat gcgctgcgaa tcgggagcgg cgataccgta     9180

aagcacgagg aagcggtcag cccattcgcc gccaagctct tcagcaatat cacgggtagc     9240

caacgctatg tcctgatagc ggtccgccac acccagccgg ccacagtcga tgaatccaga     9300

aaagcggcca ttttccacca tgatattcgg caagcaggca tcgccatggg tcacgacgag     9360

atcctcgccg tcgggcatgc tcgccttgag cctggcgaac agttcggctg gcgcgagccc     9420

ctgatgctct tcgtccagat catcctgatc gacaagaccg gcttccatcc gagtacgtgc     9480

tcgctcgatg cgatgtttcg cttggtggtc gaatgggcag gtagccggat caagcgtatg     9540

cagccgccgc attgcatcag ccatgatgga tactttctcg gcaggagcaa ggtgagatga     9600

caggagatcc tgccccggca cttcgcccaa tagcagccag tcccttcccg cttcagtgac     9660

aacgtcgagc acagctgcgc aaggaacgcc cgtcgtggcc agccacgata gccgcgctgc     9720

ctcgtcttgc agttcattca gggcaccgga caggtcggtc ttgacaaaaa gaaccgggcg     9780

cccctgcgct gacagccgga acacggcggc atcagagcag ccgattgtct gttgtgccca     9840

gtcatagccg aatagcctct ccacccaagc ggccggagaa cctgcgtgca atccatcttg     9900

ttcaatcata atattattga agcatttatc agggttcgtc tcgtcccggt ctcctcccat     9960

gcatg                                                                 9965


<210>  40
<211>  2323
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  40

Met Gly Pro Ala Met Asp Leu Ser Ala Leu Arg Val Glu Glu Val Gln 
1               5                   10                  15      


Asn Val Ile Asn Ala Met Gln Lys Ile Leu Glu Cys Pro Ile Cys Leu 
            20                  25                  30          


Glu Leu Ile Lys Glu Pro Val Ser Thr Lys Cys Asp His Ile Phe Cys 
        35                  40                  45              


Lys Phe Cys Met Leu Lys Leu Leu Asn Gln Lys Lys Gly Pro Ser Gln 
    50                  55                  60                  


Cys Pro Leu Cys Lys Asn Asp Ile Thr Lys Arg Ser Leu Gln Glu Ser 
65                  70                  75                  80  


Thr Arg Phe Ser Gln Leu Val Glu Glu Leu Leu Lys Ile Ile Cys Ala 
                85                  90                  95      


Phe Gln Leu Asp Thr Gly Leu Glu Tyr Ala Asn Ser Tyr Asn Phe Ala 
            100                 105                 110         


Lys Lys Glu Asn Asn Ser Pro Glu His Leu Lys Asp Glu Val Ser Ile 
        115                 120                 125             


Ile Gln Ser Met Gly Tyr Arg Asn Arg Ala Lys Arg Leu Leu Gln Ser 
    130                 135                 140                 


Glu Pro Glu Asn Pro Ser Leu Gln Glu Thr Ser Leu Ser Val Gln Leu 
145                 150                 155                 160 


Ser Asn Leu Gly Thr Val Arg Thr Leu Arg Thr Lys Gln Arg Ile Gln 
                165                 170                 175     


Pro Gln Lys Thr Ser Val Tyr Ile Glu Leu Gly Ser Asp Ser Ser Glu 
            180                 185                 190         


Asp Thr Val Asn Lys Ala Thr Tyr Cys Ser Val Gly Asp Gln Glu Leu 
        195                 200                 205             


Leu Gln Ile Thr Pro Gln Gly Thr Arg Asp Glu Ile Ser Leu Asp Ser 
    210                 215                 220                 


Ala Lys Lys Ala Ala Cys Glu Phe Ser Glu Thr Asp Val Thr Asn Thr 
225                 230                 235                 240 


Glu His His Gln Pro Ser Asn Asn Asp Leu Asn Thr Thr Glu Lys Arg 
                245                 250                 255     


Ala Ala Glu Arg His Pro Glu Lys Tyr Gln Gly Ser Ser Val Ser Asn 
            260                 265                 270         


Leu His Val Glu Pro Cys Gly Thr Asn Thr His Ala Ser Ser Leu Gln 
        275                 280                 285             


His Glu Asn Ser Ser Leu Leu Leu Thr Lys Asp Arg Met Asn Val Glu 
    290                 295                 300                 


Lys Ala Glu Phe Cys Asn Lys Ser Lys Gln Pro Gly Leu Ala Arg Ser 
305                 310                 315                 320 


Gln His Asn Arg Trp Ala Gly Ser Lys Glu Thr Cys Asn Asp Arg Arg 
                325                 330                 335     


Thr Pro Ser Thr Glu Lys Lys Val Asp Leu Asn Ala Asp Pro Leu Cys 
            340                 345                 350         


Glu Arg Lys Glu Trp Asn Lys Gln Lys Leu Pro Cys Ser Glu Asn Pro 
        355                 360                 365             


Arg Asp Thr Glu Asp Val Pro Trp Ile Thr Leu Asn Ser Ser Ile Gln 
    370                 375                 380                 


Lys Val Asn Glu Trp Phe Ser Arg Ser Asp Glu Leu Leu Gly Ser Asp 
385                 390                 395                 400 


Asp Ser His Asp Gly Glu Ser Glu Ser Asn Ala Lys Val Ala Asp Val 
                405                 410                 415     


Leu Asp Val Leu Asn Glu Val Asp Glu Tyr Ser Gly Ser Ser Glu Lys 
            420                 425                 430         


Ile Asp Leu Leu Ala Ser Asp Pro His Glu Ala Leu Ile Cys Lys Ser 
        435                 440                 445             


Glu Arg Val His Ser Lys Ser Val Glu Ser Asn Ile Glu Asp Lys Ile 
    450                 455                 460                 


Phe Gly Lys Thr Tyr Arg Lys Lys Ala Ser Leu Pro Asn Leu Ser His 
465                 470                 475                 480 


Val Thr Glu Asn Leu Ile Ile Gly Ala Phe Val Thr Glu Pro Gln Ile 
                485                 490                 495     


Ile Gln Glu Arg Pro Leu Thr Asn Lys Leu Lys Arg Lys Arg Arg Pro 
            500                 505                 510         


Thr Ser Gly Leu His Pro Glu Asp Phe Ile Lys Lys Ala Asp Leu Ala 
        515                 520                 525             


Val Gln Lys Thr Pro Glu Met Ile Asn Gln Gly Thr Asn Gln Thr Glu 
    530                 535                 540                 


Gln Asn Gly Gln Val Met Asn Ile Thr Asn Ser Gly His Glu Asn Lys 
545                 550                 555                 560 


Thr Lys Gly Asp Ser Ile Gln Asn Glu Lys Asn Pro Asn Pro Ile Glu 
                565                 570                 575     


Ser Leu Glu Lys Glu Ser Ala Phe Lys Thr Lys Ala Glu Pro Ile Ser 
            580                 585                 590         


Ser Ser Ile Ser Asn Met Glu Leu Glu Leu Asn Ile His Asn Ser Lys 
        595                 600                 605             


Ala Pro Lys Lys Asn Arg Leu Arg Arg Lys Ser Ser Thr Arg His Ile 
    610                 615                 620                 


His Ala Leu Glu Leu Val Val Ser Arg Asn Leu Ser Pro Pro Asn Cys 
625                 630                 635                 640 


Thr Glu Leu Gln Ile Asp Ser Cys Ser Ser Ser Glu Glu Ile Lys Lys 
                645                 650                 655     


Lys Lys Tyr Asn Gln Met Pro Val Arg His Ser Arg Asn Leu Gln Leu 
            660                 665                 670         


Met Glu Gly Lys Glu Pro Ala Thr Gly Ala Lys Lys Ser Asn Lys Pro 
        675                 680                 685             


Asn Glu Gln Thr Ser Lys Arg His Asp Ser Asp Thr Phe Pro Glu Leu 
    690                 695                 700                 


Lys Leu Thr Asn Ala Pro Gly Ser Phe Thr Lys Cys Ser Asn Thr Ser 
705                 710                 715                 720 


Glu Leu Lys Glu Phe Val Asn Pro Ser Leu Pro Arg Glu Glu Lys Glu 
                725                 730                 735     


Glu Lys Leu Glu Thr Val Lys Val Ser Asn Asn Ala Glu Asp Pro Lys 
            740                 745                 750         


Asp Leu Met Leu Ser Gly Glu Arg Val Leu Gln Thr Glu Arg Ser Val 
        755                 760                 765             


Glu Ser Ser Ser Ile Ser Leu Val Pro Gly Thr Asp Tyr Gly Thr Gln 
    770                 775                 780                 


Glu Ser Ile Ser Leu Leu Glu Val Ser Thr Leu Gly Lys Ala Lys Thr 
785                 790                 795                 800 


Glu Pro Asn Lys Cys Val Ser Gln Cys Ala Ala Phe Glu Asn Pro Lys 
                805                 810                 815     


Gly Leu Ile His Gly Cys Ser Lys Asp Asn Arg Asn Asp Thr Glu Gly 
            820                 825                 830         


Phe Lys Tyr Pro Leu Gly His Glu Val Asn His Ser Arg Glu Thr Ser 
        835                 840                 845             


Ile Glu Met Glu Glu Ser Glu Leu Asp Ala Gln Tyr Leu Gln Asn Thr 
    850                 855                 860                 


Phe Lys Val Ser Lys Arg Gln Ser Phe Ala Leu Phe Ser Asn Pro Gly 
865                 870                 875                 880 


Asn Ala Glu Glu Glu Cys Ala Thr Phe Ser Ala His Ser Gly Ser Leu 
                885                 890                 895     


Lys Lys Gln Ser Pro Lys Val Thr Phe Glu Cys Glu Gln Lys Glu Glu 
            900                 905                 910         


Asn Gln Gly Lys Asn Glu Ser Asn Ile Lys Pro Val Gln Thr Val Asn 
        915                 920                 925             


Ile Thr Ala Gly Phe Pro Val Val Gly Gln Lys Asp Lys Pro Val Asp 
    930                 935                 940                 


Asn Ala Lys Cys Ser Ile Lys Gly Gly Ser Arg Phe Cys Leu Ser Ser 
945                 950                 955                 960 


Gln Phe Arg Gly Asn Glu Thr Gly Leu Ile Thr Pro Asn Lys His Gly 
                965                 970                 975     


Leu Leu Gln Asn Pro Tyr Arg Ile Pro Pro Leu Phe Pro Ile Lys Ser 
            980                 985                 990         


Phe Val Lys Thr Lys Cys Lys Lys  Asn Leu Leu Glu Glu  Asn Phe Glu 
        995                 1000                 1005             


Glu His  Ser Met Ser Pro Glu  Arg Glu Met Gly Asn  Glu Asn Ile 
    1010                 1015                 1020             


Pro Ser  Thr Val Ser Thr Ile  Ser Arg Asn Asn Ile  Arg Glu Asn 
    1025                 1030                 1035             


Val Phe  Lys Gly Ala Ser Ser  Ser Asn Ile Asn Glu  Val Gly Ser 
    1040                 1045                 1050             


Ser Thr  Asn Glu Val Gly Ser  Ser Ile Asn Glu Ile  Gly Ser Ser 
    1055                 1060                 1065             


Asp Glu  Asn Ile Gln Ala Glu  Leu Gly Arg Asn Arg  Gly Pro Lys 
    1070                 1075                 1080             


Leu Asn  Ala Met Leu Arg Leu  Gly Val Leu Gln Pro  Glu Val Tyr 
    1085                 1090                 1095             


Lys Gln  Ser Leu Pro Gly Ser  Asn Cys Lys His Pro  Glu Ile Lys 
    1100                 1105                 1110             


Lys Gln  Glu Tyr Glu Glu Val  Val Gln Thr Val Asn  Thr Asp Phe 
    1115                 1120                 1125             


Ser Pro  Tyr Leu Ile Ser Asp  Asn Leu Glu Gln Pro  Met Gly Ser 
    1130                 1135                 1140             


Ser His  Thr Ser Gln Val Cys  Ser Glu Thr Pro Asp  Asp Leu Leu 
    1145                 1150                 1155             


Asp Asp  Gly Glu Ile Lys Glu  Asp Thr Ser Phe Ala  Glu Asn Asp 
    1160                 1165                 1170             


Ile Lys  Glu Ser Ser Ala Val  Phe Ser Lys Ser Val  Gln Arg Gly 
    1175                 1180                 1185             


Glu Leu  Ser Arg Ser Pro Ser  Pro Phe Thr His Thr  His Leu Ala 
    1190                 1195                 1200             


Gln Gly  Tyr Arg Arg Gly Ala  Lys Lys Leu Glu Ser  Ser Glu Glu 
    1205                 1210                 1215             


Asn Leu  Ser Ser Glu Asp Glu  Glu Leu Pro Cys Phe  Gln His Leu 
    1220                 1225                 1230             


Leu Phe  Gly Lys Val Asn Asn  Ile Pro Ser Gln Ser  Thr Arg His 
    1235                 1240                 1245             


Ser Thr  Val Ala Thr Glu Cys  Leu Ser Lys Asn Thr  Glu Glu Asn 
    1250                 1255                 1260             


Leu Leu  Ser Leu Lys Asn Ser  Leu Asn Asp Cys Ser  Asn Gln Val 
    1265                 1270                 1275             


Ile Leu  Ala Lys Ala Ser Gln  Glu His His Leu Ser  Glu Glu Thr 
    1280                 1285                 1290             


Lys Cys  Ser Ala Ser Leu Phe  Ser Ser Gln Cys Ser  Glu Leu Glu 
    1295                 1300                 1305             


Asp Leu  Thr Ala Asn Thr Asn  Thr Gln Asp Pro Phe  Leu Ile Gly 
    1310                 1315                 1320             


Ser Ser  Lys Gln Met Arg His  Gln Ser Glu Ser Gln  Gly Val Gly 
    1325                 1330                 1335             


Leu Ser  Asp Lys Glu Leu Val  Ser Asp Asp Glu Glu  Arg Gly Thr 
    1340                 1345                 1350             


Gly Leu  Glu Glu Asn Asn Gln  Glu Glu Gln Ser Met  Asp Ser Asn 
    1355                 1360                 1365             


Leu Gly  Glu Ala Ala Ser Gly  Cys Glu Ser Glu Thr  Ser Val Ser 
    1370                 1375                 1380             


Glu Asp  Cys Ser Gly Leu Ser  Ser Gln Ser Asp Ile  Leu Thr Thr 
    1385                 1390                 1395             


Gln Gln  Arg Asp Thr Met Gln  His Asn Leu Ile Lys  Leu Gln Gln 
    1400                 1405                 1410             


Glu Met  Ala Glu Leu Glu Ala  Val Leu Glu Gln His  Gly Ser Gln 
    1415                 1420                 1425             


Pro Ser  Asn Ser Tyr Pro Ser  Ile Ile Ser Asp Ser  Ser Ala Leu 
    1430                 1435                 1440             


Glu Asp  Leu Arg Asn Pro Glu  Gln Ser Thr Ser Glu  Lys Ala Val 
    1445                 1450                 1455             


Leu Thr  Ser Gln Lys Ser Ser  Glu Tyr Pro Ile Ser  Gln Asn Pro 
    1460                 1465                 1470             


Glu Gly  Leu Ser Ala Asp Lys  Phe Glu Val Ser Ala  Asp Ser Ser 
    1475                 1480                 1485             


Thr Ser  Lys Asn Lys Glu Pro  Gly Val Glu Arg Ser  Ser Pro Ser 
    1490                 1495                 1500             


Lys Cys  Pro Ser Leu Asp Asp  Arg Trp Tyr Met His  Ser Cys Ser 
    1505                 1510                 1515             


Gly Ser  Leu Gln Asn Arg Asn  Tyr Pro Ser Gln Glu  Glu Leu Ile 
    1520                 1525                 1530             


Lys Val  Val Asp Val Glu Glu  Gln Gln Leu Glu Glu  Ser Gly Pro 
    1535                 1540                 1545             


His Asp  Leu Thr Glu Thr Ser  Tyr Leu Pro Arg Gln  Asp Leu Glu 
    1550                 1555                 1560             


Gly Thr  Pro Tyr Leu Glu Ser  Gly Ile Ser Leu Phe  Ser Asp Asp 
    1565                 1570                 1575             


Pro Glu  Ser Asp Pro Ser Glu  Asp Arg Ala Pro Glu  Ser Ala Arg 
    1580                 1585                 1590             


Val Gly  Asn Ile Pro Ser Ser  Thr Ser Ala Leu Lys  Val Pro Gln 
    1595                 1600                 1605             


Leu Lys  Val Ala Glu Ser Ala  Gln Gly Pro Ala Ala  Ala His Thr 
    1610                 1615                 1620             


Thr Asp  Thr Ala Gly Tyr Asn  Ala Met Glu Glu Ser  Val Ser Arg 
    1625                 1630                 1635             


Glu Lys  Pro Glu Leu Thr Ala  Ser Thr Glu Arg Val  Asn Lys Arg 
    1640                 1645                 1650             


Met Ser  Met Val Val Ser Gly  Leu Thr Pro Glu Glu  Phe Met Leu 
    1655                 1660                 1665             


Val Tyr  Lys Phe Ala Arg Lys  His His Ile Thr Leu  Thr Asn Leu 
    1670                 1675                 1680             


Ile Thr  Glu Glu Thr Thr His  Val Val Met Lys Thr  Asp Ala Glu 
    1685                 1690                 1695             


Phe Val  Cys Glu Arg Thr Leu  Lys Tyr Phe Leu Gly  Ile Ala Gly 
    1700                 1705                 1710             


Gly Lys  Trp Val Val Ser Tyr  Phe Trp Val Thr Gln  Ser Ile Lys 
    1715                 1720                 1725             


Glu Arg  Lys Met Leu Asn Glu  His Asp Phe Glu Val  Arg Gly Asp 
    1730                 1735                 1740             


Val Val  Asn Gly Arg Asn His  Gln Gly Pro Lys Arg  Ala Arg Glu 
    1745                 1750                 1755             


Ser Gln  Asp Arg Lys Ile Phe  Arg Gly Leu Glu Ile  Cys Cys Tyr 
    1760                 1765                 1770             


Gly Pro  Phe Thr Asn Met Pro  Thr Asp Gln Leu Glu  Trp Met Val 
    1775                 1780                 1785             


Gln Leu  Cys Gly Ala Ser Val  Val Lys Glu Leu Ser  Ser Phe Thr 
    1790                 1795                 1800             


Leu Gly  Thr Gly Val His Pro  Ile Val Val Val Gln  Pro Asp Ala 
    1805                 1810                 1815             


Trp Thr  Glu Asp Asn Gly Phe  His Ala Ile Gly Gln  Met Cys Glu 
    1820                 1825                 1830             


Ala Pro  Val Val Thr Arg Glu  Trp Val Leu Asp Ser  Val Ala Leu 
    1835                 1840                 1845             


Tyr Gln  Cys Gln Glu Leu Asp  Thr Tyr Leu Ile Pro  Gln Ile Pro 
    1850                 1855                 1860             


His Ser  His Tyr Ile Asp Gly  Gly Gly Gly Ser Asp  Pro Lys Lys 
    1865                 1870                 1875             


Lys Arg  Lys Val Asp Pro Lys  Lys Lys Arg Lys Val  Asp Pro Lys 
    1880                 1885                 1890             


Lys Lys  Arg Lys Val Gly Ser  Thr Gly Ser Arg Asn  Asp Gly Gly 
    1895                 1900                 1905             


Gly Gly  Ser Gly Gly Gly Gly  Ser Gly Gly Gly Gly  Ser Gly Arg 
    1910                 1915                 1920             


Ala Gly  Ile Leu Pro Pro Lys  Lys Lys Arg Lys Val  Ser Arg Gly 
    1925                 1930                 1935             


Arg Ser  Arg Leu Leu Glu Asp  Phe Arg Asn Asn Arg  Tyr Pro Asn 
    1940                 1945                 1950             


Leu Gln  Leu Arg Glu Ile Ala  Gly His Ile Met Glu  Phe Ser Gln 
    1955                 1960                 1965             


Asp Gln  His Gly Ser Arg Phe  Ile Gln Leu Lys Leu  Glu Arg Ala 
    1970                 1975                 1980             


Thr Pro  Ala Glu Arg Gln Leu  Val Phe Asn Glu Ile  Leu Gln Ala 
    1985                 1990                 1995             


Ala Tyr  Gln Leu Met Val Asp  Val Phe Gly Asn Tyr  Val Ile Gln 
    2000                 2005                 2010             


Lys Phe  Phe Glu Phe Gly Ser  Leu Glu Gln Lys Leu  Ala Leu Ala 
    2015                 2020                 2025             


Glu Arg  Ile Arg Gly His Val  Leu Ser Leu Ala Leu  Gln Met Tyr 
    2030                 2035                 2040             


Gly Ser  Arg Val Ile Glu Lys  Ala Leu Glu Phe Ile  Pro Ser Asp 
    2045                 2050                 2055             


Gln Gln  Asn Glu Met Val Arg  Glu Leu Asp Gly His  Val Leu Lys 
    2060                 2065                 2070             


Cys Val  Lys Asp Gln Asn Gly  Asn His Val Val Gln  Lys Cys Ile 
    2075                 2080                 2085             


Glu Cys  Val Gln Pro Gln Ser  Leu Gln Phe Ile Ile  Asp Ala Phe 
    2090                 2095                 2100             


Lys Gly  Gln Val Phe Ala Leu  Ser Thr His Pro Tyr  Gly Cys Arg 
    2105                 2110                 2115             


Val Ile  Gln Arg Ile Leu Glu  His Cys Leu Pro Asp  Gln Thr Leu 
    2120                 2125                 2130             


Pro Ile  Leu Glu Glu Leu His  Gln His Thr Glu Gln  Leu Val Gln 
    2135                 2140                 2145             


Asp Gln  Tyr Gly Asn Tyr Val  Ile Gln His Val Leu  Glu His Gly 
    2150                 2155                 2160             


Arg Pro  Glu Asp Lys Ser Lys  Ile Val Ala Glu Ile  Arg Gly Asn 
    2165                 2170                 2175             


Val Leu  Val Leu Ser Gln His  Lys Phe Ala Ser Asn  Val Val Glu 
    2180                 2185                 2190             


Lys Cys  Val Thr His Ala Ser  Arg Thr Glu Arg Ala  Val Leu Ile 
    2195                 2200                 2205             


Asp Glu  Val Cys Thr Met Asn  Asp Gly Pro His Ser  Ala Leu Tyr 
    2210                 2215                 2220             


Thr Met  Met Lys Asp Gln Tyr  Ala Asn Tyr Val Val  Gln Lys Met 
    2225                 2230                 2235             


Ile Asp  Val Ala Glu Pro Gly  Gln Arg Lys Ile Val  Met His Lys 
    2240                 2245                 2250             


Ile Arg  Pro His Ile Ala Thr  Leu Arg Lys Tyr Thr  Tyr Gly Lys 
    2255                 2260                 2265             


His Ile  Leu Ala Lys Leu Glu  Lys Tyr Tyr Met Lys  Asn Gly Val 
    2270                 2275                 2280             


Asp Leu  Gly Asp Pro Lys Lys  Lys Arg Lys Val Asp  Pro Lys Lys 
    2285                 2290                 2295             


Lys Arg  Lys Val Gly Gly Arg  Gly Gly Gly Gly Ser  Gly Gly Gly 
    2300                 2305                 2310             


Gly Ser  Gly Gly Gly Gly Ser  Gly Pro Ala 
    2315                 2320             


<210>  41
<211>  9962
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide

<400>  41
tcaatattgg ccattagcca tattattcat tggttatata gcataaatca atattggcta       60

ttggccattg catacgttgt atctatatca taatatgtac atttatattg gctcatgtcc      120

aatatgaccg ccatgttggc attgattatt gactagttat taatagtaat caattacggg      180

gtcattagtt catagcccat atatggagtt ccgcgttaca taacttacgg taaatggccc      240

gcctggctga ccgcccaacg acccccgccc attgacgtca ataatgacgt atgttcccat      300

agtaacgcca atagggactt tccattgacg tcaatgggtg gagtatttac ggtaaactgc      360

ccacttggca gtacatcaag tgtatcatat gccaagtccg ccccctattg acgtcaatga      420

cggtaaatgg cccgcctggc attatgccca gtacatgacc ttacgggact ttcctacttg      480

gcagtacatc tacgtattag tcatcgctat taccatggtg atgcggtttt ggcagtacac      540

caatgggcgt ggatagcggt ttgactcacg gggatttcca agtctccacc ccattgacgt      600

caatgggagt ttgttttggc accaaaatca acgggacttt ccaaaatgtc gtaataaccc      660

cgccccgttg acgcaaatgg gcggtaggcg tgtacggtgg gaggtctata taagcagagg      720

tcgtttagtg aaccgtcaga tcactagtag ctttattgcg gtagtttatc acagttaaat      780

tgctaacgca gtcagtgctc gactgatcac aggtaagtat caaggttaca agacaggttt      840

aaggaggcca atagaaactg ggcttgtcga gacagagaag attcttgcgt ttctgatagg      900

cacctattgg tcttactgac atccactttg cctttctctc cacagggaaa aaacaattga      960

caagtttgta caaaaaagca ggctccgaat tcaccggtgc cgccaccatg atcgatggcg     1020

gaggcggatc tgatccaaaa aagaagagaa aggtagatcc aaaaaagaag agaaaggtag     1080

atccaaaaaa gaagagaaag gtaggatcta ccggatctag aaacgatggt ggtggtggaa     1140

gcgggggtgg gggcagcggt ggagggggaa gcgggcgcgc cgggatcctc ccccccaaga     1200

aaaagaggaa ggtatctaga ggccgcagcc gccttttgga agattttcga aacaaccggt     1260

accccaattt acaactgcgg gagattgctg gacatataat ggaattttcc caagaccagc     1320

atgggtccag attcattcag ctgaaactgg agcgtgccac accagctgag cgccagcttg     1380

tcttcaatga aatcctccag gctgcctacc aactcatggt ggatgtgttt ggtaattacg     1440

tcattcagaa gttctttgaa tttggcagtc ttgaacagaa gctggctttg gcagaacgga     1500

ttcgaggcca cgtcctgtca ttggcactac agatgtatgg cagccgtgtt atcgagaaag     1560

ctcttgagtt tattccttca gaccagcaga atgagatggt tcgggaacta gatggccatg     1620

tcttgaagtg tgtgaaagat cagaatggca atcacgtggt tcagaaatgc attgaatgtg     1680

tacagcccca gtctttgcaa tttatcatcg acgcgtttaa gggacaggta tttgccttat     1740

ccacacatcc ttatggctgc cgagtgattc agagaatcct ggagcactgt ctccctgacc     1800

agacactccc tattttagag gagcttcacc agcacacaga gcagctggta caggatcaat     1860

atggaaatta tgtaatccaa catgtactgg agcacggtcg tcctgaggat aaaagcaaaa     1920

ttgtagcaga aatccgaggc aatgtacttg tattgagtca gcacaaattt gcaagcaatg     1980

ttgtggagaa gtgtgttact cacgcctcac gtacggagcg cgctgtgctc atcgacgagg     2040

tgtgcaccat gaacgacggt ccccacagtg ccttatacac catgatgaag gaccagtatg     2100

ccaactacgt ggtccagaag atgattgacg tggcggagcc aggccagcgg aagatcgtca     2160

tgcataagat ccggccccac atcgcaactc ttcgtaagta cacctatggc aagcacattc     2220

tggccaagct ggagaagtac tacatgaaga acggtgttga cttaggggac ccaaagaaga     2280

agcgcaaagt ggatcctaaa aagaaaagaa aggtaggcgg ccgcggggga ggcggttccg     2340

gtggcggcgg aagcggaggt ggaggatcag ggccggccat ggatttatct gctcttcgcg     2400

ttgaagaagt acaaaatgtc attaatgcta tgcagaaaat cttagagtgt cccatctgtc     2460

tggagttgat caaggaacct gtctccacaa agtgtgacca catattttgc aaattttgca     2520

tgctgaaact tctcaaccag aagaaagggc cttcacagtg tcctttatgt aagaatgata     2580

taaccaaaag gagcctacaa gaaagtacga gatttagtca acttgttgaa gagctattga     2640

aaatcatttg tgcttttcag cttgacacag gtttggagta tgcaaacagc tataattttg     2700

caaaaaagga aaataactct cctgaacatc taaaagatga agtttctatc atccaaagta     2760

tgggctacag aaaccgtgcc aaaagacttc tacagagtga acccgaaaat ccttccttgc     2820

aggaaaccag tctcagtgtc caactctcta accttggaac tgtgagaact ctgaggacaa     2880

agcagcggat acaacctcaa aagacgtctg tctacattga attgggatct gattcttctg     2940

aagataccgt taataaggca acttattgca gtgtgggaga tcaagaattg ttacaaatca     3000

cccctcaagg aaccagggat gaaatcagtt tggattctgc aaaaaaggct gcttgtgaat     3060

tttctgagac ggatgtaaca aatactgaac atcatcaacc cagtaataat gatttgaaca     3120

ccactgagaa gcgtgcagct gagaggcatc cagaaaagta tcagggtagt tctgtttcaa     3180

acttgcatgt ggagccatgt ggcacaaata ctcatgccag ctcattacag catgagaaca     3240

gcagtttatt actcactaaa gacagaatga atgtagaaaa ggctgaattc tgtaataaaa     3300

gcaaacagcc tggcttagca aggagccaac ataacagatg ggctggaagt aaggaaacat     3360

gtaatgatag gcggactccc agcacagaaa aaaaggtaga tctgaatgct gatcccctgt     3420

gtgagagaaa agaatggaat aagcagaaac tgccatgctc agagaatcct agagatactg     3480

aagatgttcc ttggataaca ctaaatagca gcattcagaa agttaatgag tggttttcca     3540

gaagtgatga actgttaggt tctgatgact cacatgatgg ggagtctgaa tcaaatgcca     3600

aagtagctga tgtattggac gttctaaatg aggtagatga atattctggt tcttcagaga     3660

aaatagactt actggccagt gatcctcatg aggctttaat atgtaaaagt gaaagagttc     3720

actccaaatc agtagagagt aatattgaag acaaaatatt tgggaaaacc tatcggaaga     3780

aggcaagcct ccccaactta agccatgtaa ctgaaaatct aattatagga gcatttgtta     3840

ctgagccaca gataatacaa gagcgtcccc tcacaaataa attaaagcgt aaaaggagac     3900

ctacatcagg ccttcatcct gaggatttta tcaagaaagc agatttggca gttcaaaaga     3960

ctcctgaaat gataaatcag ggaactaacc aaacggagca gaatggtcaa gtgatgaata     4020

ttactaatag tggtcatgag aataaaacaa aaggtgattc tattcagaat gagaaaaatc     4080

ctaacccaat agaatcactc gaaaaagaat ctgctttcaa aacgaaagct gaacctataa     4140

gcagcagtat aagcaatatg gaactcgaat taaatatcca caattcaaaa gcacctaaaa     4200

agaataggct gaggaggaag tcttctacca ggcatattca tgcgcttgaa ctagtagtca     4260

gtagaaatct aagcccacct aattgtactg aattgcaaat tgatagttgt tctagcagtg     4320

aagagataaa gaaaaaaaag tacaaccaaa tgccagtcag gcacagcaga aacctacaac     4380

tcatggaagg taaagaacct gcaactggag ccaagaagag taacaagcca aatgaacaga     4440

caagtaaaag acatgacagt gatactttcc cagagctgaa gttaacaaat gcacctggtt     4500

cttttactaa gtgttcaaat accagtgaac ttaaagaatt tgtcaatcct agccttccaa     4560

gagaagaaaa agaagagaaa ctagaaacag ttaaagtgtc taataatgct gaagacccca     4620

aagatctcat gttaagtgga gaaagggttt tgcaaactga aagatctgta gagagtagca     4680

gtatttcact ggtacctggt actgattatg gcactcagga aagtatctcg ttactggaag     4740

ttagcactct agggaaggca aaaacagaac caaataaatg tgtgagtcag tgtgcagcat     4800

ttgaaaaccc caagggacta attcatggtt gttccaaaga taatagaaat gacacagaag     4860

gctttaagta tccattggga catgaagtta accacagtcg ggaaacaagc atagaaatgg     4920

aagaaagtga acttgatgct cagtatttgc agaatacatt caaggtttca aagcgccagt     4980

catttgctct gttttcaaat ccaggaaatg cagaagagga atgtgcaaca ttctctgccc     5040

actctgggtc cttaaagaaa caaagtccaa aagtcacttt tgaatgtgaa caaaaggaag     5100

aaaatcaagg aaagaatgag tctaatatca agcctgtaca gacagttaat atcactgcag     5160

gctttcctgt ggttggtcag aaagataagc cagttgataa tgccaaatgt agtatcaaag     5220

gaggctctag gttttgtcta tcatctcagt tcagaggcaa cgaaactgga ctcattactc     5280

caaataaaca tggactttta caaaacccat atcgtatacc accacttttt cccatcaagt     5340

catttgttaa aactaaatgt aagaaaaatc tgctagagga aaactttgag gaacattcaa     5400

tgtcacctga aagagaaatg ggaaatgaga acattccaag tacagtgagc acaattagcc     5460

gtaataacat tagagaaaat gtttttaaag gagccagctc aagcaatatt aatgaagtag     5520

gttccagtac taatgaagtg ggctccagta ttaatgaaat aggttccagt gatgaaaaca     5580

ttcaagcaga actaggtaga aacagagggc caaaattgaa tgctatgctt agattagggg     5640

ttttgcaacc tgaggtctat aaacaaagtc ttcctggaag taattgtaag catcctgaaa     5700

taaaaaagca agaatatgaa gaagtagttc agactgttaa tacagatttc tctccatatc     5760

tgatttcaga taacttagaa cagcctatgg gaagtagtca tacatctcag gtttgttctg     5820

agacacctga tgacctgtta gatgatggtg aaataaagga agatactagt tttgctgaaa     5880

atgacattaa ggaaagttct gctgttttta gcaaaagcgt ccagagagga gagcttagca     5940

ggagtcctag ccctttcacc catacacatt tggctcaggg ttaccgaaga ggggccaaga     6000

aattagagtc ctcagaagag aacttatcta gtgaggatga agagcttccc tgcttccaac     6060

acttgttatt tggtaaagta aacaatatac cttctcagtc tactaggcat agcaccgttg     6120

ctaccgagtg tctgtctaag aacacagagg agaatttatt atcattgaag aatagcttaa     6180

atgactgcag taaccaggta atattggcaa aggcatctca ggaacatcac cttagtgagg     6240

aaacaaaatg ttctgctagc ttgttttctt cacagtgcag tgaattggaa gacttgactg     6300

caaatacaaa cacccaggat cctttcttga ttggttcttc caaacaaatg aggcatcagt     6360

ctgaaagcca gggagttggt ctgagtgaca aggaattggt ttcagatgat gaagaaagag     6420

gaacgggctt ggaagaaaat aatcaagaag agcaaagcat ggattcaaac ttaggtgaag     6480

cagcatctgg gtgtgagagt gaaacaagcg tctctgaaga ctgctcaggg ctatcctctc     6540

agagtgacat tttaaccact cagcagaggg ataccatgca acataacctg ataaagctcc     6600

agcaggaaat ggctgaacta gaagctgtgt tagaacagca tgggagccag ccttctaaca     6660

gctaccctag tataatcagt gactcttctg cccttgagga cctgcgaaat ccagaacaaa     6720

gcacatcaga aaaagcagta ttaacttcac agaaaagtag tgaataccct ataagccaga     6780

atccagaagg cctttctgct gacaagtttg aggtgtctgc agatagttct accagtaaaa     6840

ataaagaacc aggagtggaa aggtcatccc cttctaaatg cccatcatta gatgataggt     6900

ggtacatgca cagttgctct gggagtcttc agaatagaaa ctacccatct caagaggagc     6960

tcattaaggt tgttgatgtg gaggagcaac agctggaaga gtctgggcca cacgatttga     7020

cggaaacatc ttacttgcca aggcaagatc tagagggaac cccttacctg gaatctggaa     7080

tcagcctctt ctctgatgac cctgaatctg atccttctga agacagagcc ccagagtcag     7140

ctcgtgttgg caacatacca tcttcaacct ctgcattgaa agttccccaa ttgaaagttg     7200

cagaatctgc ccagggtcca gctgctgctc atactactga tactgctggg tataatgcaa     7260

tggaagaaag tgtgagcagg gagaagccag aattgacagc ttcaacagaa agggtcaaca     7320

aaagaatgtc catggtggtg tctggcctga ccccagaaga atttatgctc gtgtacaagt     7380

ttgccagaaa acaccacatc actttaacta atctaattac tgaagagact actcatgttg     7440

ttatgaaaac agatgctgag tttgtgtgtg aacggacact gaaatatttt ctaggaattg     7500

cgggaggaaa atgggtagtt agctatttct gggtgaccca gtctattaaa gaaagaaaaa     7560

tgctgaatga gcatgatttt gaagtcagag gagatgtggt caatggaaga aaccaccaag     7620

gtccaaagcg agcaagagaa tcccaggaca gaaagatctt cagggggcta gaaatctgtt     7680

gctatgggcc cttcaccaac atgcccacag atcaactgga atggatggta cagctgtgtg     7740

gtgcttctgt ggtgaaggag ctttcatcat tcacccttgg cacaggtgtc cacccaattg     7800

tggttgtgca gccagatgcc tggacagagg acaatggctt ccatgcaatt gggcagatgt     7860

gtgaggcacc tgtggtgacc cgagagtggg tgttggacag tgtagcactc taccagtgcc     7920

aggagctgga cacctacctg ataccccaga tcccccacag ccactacatc gattgattaa     7980

ttaagaattc gacccagctt tcttgtacaa agtggttgat atccagcaca gtggcggccg     8040

ctcgagtcta gagggcccgc ggttcgaagg taagcctatc cctaaccctc tcctcggtct     8100

cgattctacg cgtaccggtt agcaattgtt ttttcgatga gtttggacaa accacaacta     8160

gaatgcagtg aaaaaaatgc tttatttgtg aaatttgtga tgctattgct ttatttgtaa     8220

ccattataag ctgcaataaa caagttaaca acaacaattg cattcatttt atgtttcagg     8280

ttcaggggga ggtgtgggag gttttttaaa gcaagtaaaa cctctacaaa tgtggtactt     8340

aagaggggga gaccaaaggg cgagacgtta aggcctcacg tgacatgtga gcaaaaggcc     8400

agcaaaaggc caggaaccgt aaaaaggccg cgttgctggc gtttttccat aggctccgcc     8460

cccctgacga gcatcacaaa aatcgacgct caagtcagag gtggcgaaac ccgacaggac     8520

tataaagata ccaggcgttt ccccctggaa gctccctcgt gcgctctcct gttccgaccc     8580

tgccgcttac cggatacctg tccgcctttc tcccttcggg aagcgtggcg ctttctcata     8640

gctcacgctg taggtatctc agttcggtgt aggtcgttcg ctccaagctg ggctgtgtgc     8700

acgaaccccc cgttcagccc gaccgctgcg ccttatccgg taactatcgt cttgagtcca     8760

acccggtaag acacgactta tcgccactgg cagcagccac tggtaacagg attagcagag     8820

cgaggtatgt aggcggtgct acagagttct tgaagtggtg gcctaactac ggctacacta     8880

gaaggacagt atttggtatc tgcgctctgc tgaagccagt taccttcgga aaaagagttg     8940

gtagctcttg atccggcaaa caaaccacgc tggtagcggt ggtttttttg tttgcaagca     9000

gcagattacg cgcagaaaaa aaggatctca agaagatcct ttgatctttt ctacggggtc     9060

tgacgctcag tggaacgaaa actcacgtta agggattttg gtcatgccgt ctcagaagaa     9120

ctcgtcaaga aggcgataga aggcgatgcg ctgcgaatcg ggagcggcga taccgtaaag     9180

cacgaggaag cggtcagccc attcgccgcc aagctcttca gcaatatcac gggtagccaa     9240

cgctatgtcc tgatagcggt ccgccacacc cagccggcca cagtcgatga atccagaaaa     9300

gcggccattt tccaccatga tattcggcaa gcaggcatcg ccatgggtca cgacgagatc     9360

ctcgccgtcg ggcatgctcg ccttgagcct ggcgaacagt tcggctggcg cgagcccctg     9420

atgctcttcg tccagatcat cctgatcgac aagaccggct tccatccgag tacgtgctcg     9480

ctcgatgcga tgtttcgctt ggtggtcgaa tgggcaggta gccggatcaa gcgtatgcag     9540

ccgccgcatt gcatcagcca tgatggatac tttctcggca ggagcaaggt gagatgacag     9600

gagatcctgc cccggcactt cgcccaatag cagccagtcc cttcccgctt cagtgacaac     9660

gtcgagcaca gctgcgcaag gaacgcccgt cgtggccagc cacgatagcc gcgctgcctc     9720

gtcttgcagt tcattcaggg caccggacag gtcggtcttg acaaaaagaa ccgggcgccc     9780

ctgcgctgac agccggaaca cggcggcatc agagcagccg attgtctgtt gtgcccagtc     9840

atagccgaat agcctctcca cccaagcggc cggagaacct gcgtgcaatc catcttgttc     9900

aatcataata ttattgaagc atttatcagg gttcgtctcg tcccggtctc ctcccatgca     9960

tg                                                                    9962


<210>  42
<211>  2322
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  42

Met Ile Asp Gly Gly Gly Gly Ser Asp Pro Lys Lys Lys Arg Lys Val 
1               5                   10                  15      


Asp Pro Lys Lys Lys Arg Lys Val Asp Pro Lys Lys Lys Arg Lys Val 
            20                  25                  30          


Gly Ser Thr Gly Ser Arg Asn Asp Gly Gly Gly Gly Ser Gly Gly Gly 
        35                  40                  45              


Gly Ser Gly Gly Gly Gly Ser Gly Arg Ala Gly Ile Leu Pro Pro Lys 
    50                  55                  60                  


Lys Lys Arg Lys Val Ser Arg Gly Arg Ser Arg Leu Leu Glu Asp Phe 
65                  70                  75                  80  


Arg Asn Asn Arg Tyr Pro Asn Leu Gln Leu Arg Glu Ile Ala Gly His 
                85                  90                  95      


Ile Met Glu Phe Ser Gln Asp Gln His Gly Ser Arg Phe Ile Gln Leu 
            100                 105                 110         


Lys Leu Glu Arg Ala Thr Pro Ala Glu Arg Gln Leu Val Phe Asn Glu 
        115                 120                 125             


Ile Leu Gln Ala Ala Tyr Gln Leu Met Val Asp Val Phe Gly Asn Tyr 
    130                 135                 140                 


Val Ile Gln Lys Phe Phe Glu Phe Gly Ser Leu Glu Gln Lys Leu Ala 
145                 150                 155                 160 


Leu Ala Glu Arg Ile Arg Gly His Val Leu Ser Leu Ala Leu Gln Met 
                165                 170                 175     


Tyr Gly Ser Arg Val Ile Glu Lys Ala Leu Glu Phe Ile Pro Ser Asp 
            180                 185                 190         


Gln Gln Asn Glu Met Val Arg Glu Leu Asp Gly His Val Leu Lys Cys 
        195                 200                 205             


Val Lys Asp Gln Asn Gly Asn His Val Val Gln Lys Cys Ile Glu Cys 
    210                 215                 220                 


Val Gln Pro Gln Ser Leu Gln Phe Ile Ile Asp Ala Phe Lys Gly Gln 
225                 230                 235                 240 


Val Phe Ala Leu Ser Thr His Pro Tyr Gly Cys Arg Val Ile Gln Arg 
                245                 250                 255     


Ile Leu Glu His Cys Leu Pro Asp Gln Thr Leu Pro Ile Leu Glu Glu 
            260                 265                 270         


Leu His Gln His Thr Glu Gln Leu Val Gln Asp Gln Tyr Gly Asn Tyr 
        275                 280                 285             


Val Ile Gln His Val Leu Glu His Gly Arg Pro Glu Asp Lys Ser Lys 
    290                 295                 300                 


Ile Val Ala Glu Ile Arg Gly Asn Val Leu Val Leu Ser Gln His Lys 
305                 310                 315                 320 


Phe Ala Ser Asn Val Val Glu Lys Cys Val Thr His Ala Ser Arg Thr 
                325                 330                 335     


Glu Arg Ala Val Leu Ile Asp Glu Val Cys Thr Met Asn Asp Gly Pro 
            340                 345                 350         


His Ser Ala Leu Tyr Thr Met Met Lys Asp Gln Tyr Ala Asn Tyr Val 
        355                 360                 365             


Val Gln Lys Met Ile Asp Val Ala Glu Pro Gly Gln Arg Lys Ile Val 
    370                 375                 380                 


Met His Lys Ile Arg Pro His Ile Ala Thr Leu Arg Lys Tyr Thr Tyr 
385                 390                 395                 400 


Gly Lys His Ile Leu Ala Lys Leu Glu Lys Tyr Tyr Met Lys Asn Gly 
                405                 410                 415     


Val Asp Leu Gly Asp Pro Lys Lys Lys Arg Lys Val Asp Pro Lys Lys 
            420                 425                 430         


Lys Arg Lys Val Gly Gly Arg Gly Gly Gly Gly Ser Gly Gly Gly Gly 
        435                 440                 445             


Ser Gly Gly Gly Gly Ser Gly Pro Ala Met Asp Leu Ser Ala Leu Arg 
    450                 455                 460                 


Val Glu Glu Val Gln Asn Val Ile Asn Ala Met Gln Lys Ile Leu Glu 
465                 470                 475                 480 


Cys Pro Ile Cys Leu Glu Leu Ile Lys Glu Pro Val Ser Thr Lys Cys 
                485                 490                 495     


Asp His Ile Phe Cys Lys Phe Cys Met Leu Lys Leu Leu Asn Gln Lys 
            500                 505                 510         


Lys Gly Pro Ser Gln Cys Pro Leu Cys Lys Asn Asp Ile Thr Lys Arg 
        515                 520                 525             


Ser Leu Gln Glu Ser Thr Arg Phe Ser Gln Leu Val Glu Glu Leu Leu 
    530                 535                 540                 


Lys Ile Ile Cys Ala Phe Gln Leu Asp Thr Gly Leu Glu Tyr Ala Asn 
545                 550                 555                 560 


Ser Tyr Asn Phe Ala Lys Lys Glu Asn Asn Ser Pro Glu His Leu Lys 
                565                 570                 575     


Asp Glu Val Ser Ile Ile Gln Ser Met Gly Tyr Arg Asn Arg Ala Lys 
            580                 585                 590         


Arg Leu Leu Gln Ser Glu Pro Glu Asn Pro Ser Leu Gln Glu Thr Ser 
        595                 600                 605             


Leu Ser Val Gln Leu Ser Asn Leu Gly Thr Val Arg Thr Leu Arg Thr 
    610                 615                 620                 


Lys Gln Arg Ile Gln Pro Gln Lys Thr Ser Val Tyr Ile Glu Leu Gly 
625                 630                 635                 640 


Ser Asp Ser Ser Glu Asp Thr Val Asn Lys Ala Thr Tyr Cys Ser Val 
                645                 650                 655     


Gly Asp Gln Glu Leu Leu Gln Ile Thr Pro Gln Gly Thr Arg Asp Glu 
            660                 665                 670         


Ile Ser Leu Asp Ser Ala Lys Lys Ala Ala Cys Glu Phe Ser Glu Thr 
        675                 680                 685             


Asp Val Thr Asn Thr Glu His His Gln Pro Ser Asn Asn Asp Leu Asn 
    690                 695                 700                 


Thr Thr Glu Lys Arg Ala Ala Glu Arg His Pro Glu Lys Tyr Gln Gly 
705                 710                 715                 720 


Ser Ser Val Ser Asn Leu His Val Glu Pro Cys Gly Thr Asn Thr His 
                725                 730                 735     


Ala Ser Ser Leu Gln His Glu Asn Ser Ser Leu Leu Leu Thr Lys Asp 
            740                 745                 750         


Arg Met Asn Val Glu Lys Ala Glu Phe Cys Asn Lys Ser Lys Gln Pro 
        755                 760                 765             


Gly Leu Ala Arg Ser Gln His Asn Arg Trp Ala Gly Ser Lys Glu Thr 
    770                 775                 780                 


Cys Asn Asp Arg Arg Thr Pro Ser Thr Glu Lys Lys Val Asp Leu Asn 
785                 790                 795                 800 


Ala Asp Pro Leu Cys Glu Arg Lys Glu Trp Asn Lys Gln Lys Leu Pro 
                805                 810                 815     


Cys Ser Glu Asn Pro Arg Asp Thr Glu Asp Val Pro Trp Ile Thr Leu 
            820                 825                 830         


Asn Ser Ser Ile Gln Lys Val Asn Glu Trp Phe Ser Arg Ser Asp Glu 
        835                 840                 845             


Leu Leu Gly Ser Asp Asp Ser His Asp Gly Glu Ser Glu Ser Asn Ala 
    850                 855                 860                 


Lys Val Ala Asp Val Leu Asp Val Leu Asn Glu Val Asp Glu Tyr Ser 
865                 870                 875                 880 


Gly Ser Ser Glu Lys Ile Asp Leu Leu Ala Ser Asp Pro His Glu Ala 
                885                 890                 895     


Leu Ile Cys Lys Ser Glu Arg Val His Ser Lys Ser Val Glu Ser Asn 
            900                 905                 910         


Ile Glu Asp Lys Ile Phe Gly Lys Thr Tyr Arg Lys Lys Ala Ser Leu 
        915                 920                 925             


Pro Asn Leu Ser His Val Thr Glu Asn Leu Ile Ile Gly Ala Phe Val 
    930                 935                 940                 


Thr Glu Pro Gln Ile Ile Gln Glu Arg Pro Leu Thr Asn Lys Leu Lys 
945                 950                 955                 960 


Arg Lys Arg Arg Pro Thr Ser Gly Leu His Pro Glu Asp Phe Ile Lys 
                965                 970                 975     


Lys Ala Asp Leu Ala Val Gln Lys Thr Pro Glu Met Ile Asn Gln Gly 
            980                 985                 990         


Thr Asn Gln Thr Glu Gln Asn Gly  Gln Val Met Asn Ile  Thr Asn Ser 
        995                 1000                 1005             


Gly His  Glu Asn Lys Thr Lys  Gly Asp Ser Ile Gln  Asn Glu Lys 
    1010                 1015                 1020             


Asn Pro  Asn Pro Ile Glu Ser  Leu Glu Lys Glu Ser  Ala Phe Lys 
    1025                 1030                 1035             


Thr Lys  Ala Glu Pro Ile Ser  Ser Ser Ile Ser Asn  Met Glu Leu 
    1040                 1045                 1050             


Glu Leu  Asn Ile His Asn Ser  Lys Ala Pro Lys Lys  Asn Arg Leu 
    1055                 1060                 1065             


Arg Arg  Lys Ser Ser Thr Arg  His Ile His Ala Leu  Glu Leu Val 
    1070                 1075                 1080             


Val Ser  Arg Asn Leu Ser Pro  Pro Asn Cys Thr Glu  Leu Gln Ile 
    1085                 1090                 1095             


Asp Ser  Cys Ser Ser Ser Glu  Glu Ile Lys Lys Lys  Lys Tyr Asn 
    1100                 1105                 1110             


Gln Met  Pro Val Arg His Ser  Arg Asn Leu Gln Leu  Met Glu Gly 
    1115                 1120                 1125             


Lys Glu  Pro Ala Thr Gly Ala  Lys Lys Ser Asn Lys  Pro Asn Glu 
    1130                 1135                 1140             


Gln Thr  Ser Lys Arg His Asp  Ser Asp Thr Phe Pro  Glu Leu Lys 
    1145                 1150                 1155             


Leu Thr  Asn Ala Pro Gly Ser  Phe Thr Lys Cys Ser  Asn Thr Ser 
    1160                 1165                 1170             


Glu Leu  Lys Glu Phe Val Asn  Pro Ser Leu Pro Arg  Glu Glu Lys 
    1175                 1180                 1185             


Glu Glu  Lys Leu Glu Thr Val  Lys Val Ser Asn Asn  Ala Glu Asp 
    1190                 1195                 1200             


Pro Lys  Asp Leu Met Leu Ser  Gly Glu Arg Val Leu  Gln Thr Glu 
    1205                 1210                 1215             


Arg Ser  Val Glu Ser Ser Ser  Ile Ser Leu Val Pro  Gly Thr Asp 
    1220                 1225                 1230             


Tyr Gly  Thr Gln Glu Ser Ile  Ser Leu Leu Glu Val  Ser Thr Leu 
    1235                 1240                 1245             


Gly Lys  Ala Lys Thr Glu Pro  Asn Lys Cys Val Ser  Gln Cys Ala 
    1250                 1255                 1260             


Ala Phe  Glu Asn Pro Lys Gly  Leu Ile His Gly Cys  Ser Lys Asp 
    1265                 1270                 1275             


Asn Arg  Asn Asp Thr Glu Gly  Phe Lys Tyr Pro Leu  Gly His Glu 
    1280                 1285                 1290             


Val Asn  His Ser Arg Glu Thr  Ser Ile Glu Met Glu  Glu Ser Glu 
    1295                 1300                 1305             


Leu Asp  Ala Gln Tyr Leu Gln  Asn Thr Phe Lys Val  Ser Lys Arg 
    1310                 1315                 1320             


Gln Ser  Phe Ala Leu Phe Ser  Asn Pro Gly Asn Ala  Glu Glu Glu 
    1325                 1330                 1335             


Cys Ala  Thr Phe Ser Ala His  Ser Gly Ser Leu Lys  Lys Gln Ser 
    1340                 1345                 1350             


Pro Lys  Val Thr Phe Glu Cys  Glu Gln Lys Glu Glu  Asn Gln Gly 
    1355                 1360                 1365             


Lys Asn  Glu Ser Asn Ile Lys  Pro Val Gln Thr Val  Asn Ile Thr 
    1370                 1375                 1380             


Ala Gly  Phe Pro Val Val Gly  Gln Lys Asp Lys Pro  Val Asp Asn 
    1385                 1390                 1395             


Ala Lys  Cys Ser Ile Lys Gly  Gly Ser Arg Phe Cys  Leu Ser Ser 
    1400                 1405                 1410             


Gln Phe  Arg Gly Asn Glu Thr  Gly Leu Ile Thr Pro  Asn Lys His 
    1415                 1420                 1425             


Gly Leu  Leu Gln Asn Pro Tyr  Arg Ile Pro Pro Leu  Phe Pro Ile 
    1430                 1435                 1440             


Lys Ser  Phe Val Lys Thr Lys  Cys Lys Lys Asn Leu  Leu Glu Glu 
    1445                 1450                 1455             


Asn Phe  Glu Glu His Ser Met  Ser Pro Glu Arg Glu  Met Gly Asn 
    1460                 1465                 1470             


Glu Asn  Ile Pro Ser Thr Val  Ser Thr Ile Ser Arg  Asn Asn Ile 
    1475                 1480                 1485             


Arg Glu  Asn Val Phe Lys Gly  Ala Ser Ser Ser Asn  Ile Asn Glu 
    1490                 1495                 1500             


Val Gly  Ser Ser Thr Asn Glu  Val Gly Ser Ser Ile  Asn Glu Ile 
    1505                 1510                 1515             


Gly Ser  Ser Asp Glu Asn Ile  Gln Ala Glu Leu Gly  Arg Asn Arg 
    1520                 1525                 1530             


Gly Pro  Lys Leu Asn Ala Met  Leu Arg Leu Gly Val  Leu Gln Pro 
    1535                 1540                 1545             


Glu Val  Tyr Lys Gln Ser Leu  Pro Gly Ser Asn Cys  Lys His Pro 
    1550                 1555                 1560             


Glu Ile  Lys Lys Gln Glu Tyr  Glu Glu Val Val Gln  Thr Val Asn 
    1565                 1570                 1575             


Thr Asp  Phe Ser Pro Tyr Leu  Ile Ser Asp Asn Leu  Glu Gln Pro 
    1580                 1585                 1590             


Met Gly  Ser Ser His Thr Ser  Gln Val Cys Ser Glu  Thr Pro Asp 
    1595                 1600                 1605             


Asp Leu  Leu Asp Asp Gly Glu  Ile Lys Glu Asp Thr  Ser Phe Ala 
    1610                 1615                 1620             


Glu Asn  Asp Ile Lys Glu Ser  Ser Ala Val Phe Ser  Lys Ser Val 
    1625                 1630                 1635             


Gln Arg  Gly Glu Leu Ser Arg  Ser Pro Ser Pro Phe  Thr His Thr 
    1640                 1645                 1650             


His Leu  Ala Gln Gly Tyr Arg  Arg Gly Ala Lys Lys  Leu Glu Ser 
    1655                 1660                 1665             


Ser Glu  Glu Asn Leu Ser Ser  Glu Asp Glu Glu Leu  Pro Cys Phe 
    1670                 1675                 1680             


Gln His  Leu Leu Phe Gly Lys  Val Asn Asn Ile Pro  Ser Gln Ser 
    1685                 1690                 1695             


Thr Arg  His Ser Thr Val Ala  Thr Glu Cys Leu Ser  Lys Asn Thr 
    1700                 1705                 1710             


Glu Glu  Asn Leu Leu Ser Leu  Lys Asn Ser Leu Asn  Asp Cys Ser 
    1715                 1720                 1725             


Asn Gln  Val Ile Leu Ala Lys  Ala Ser Gln Glu His  His Leu Ser 
    1730                 1735                 1740             


Glu Glu  Thr Lys Cys Ser Ala  Ser Leu Phe Ser Ser  Gln Cys Ser 
    1745                 1750                 1755             


Glu Leu  Glu Asp Leu Thr Ala  Asn Thr Asn Thr Gln  Asp Pro Phe 
    1760                 1765                 1770             


Leu Ile  Gly Ser Ser Lys Gln  Met Arg His Gln Ser  Glu Ser Gln 
    1775                 1780                 1785             


Gly Val  Gly Leu Ser Asp Lys  Glu Leu Val Ser Asp  Asp Glu Glu 
    1790                 1795                 1800             


Arg Gly  Thr Gly Leu Glu Glu  Asn Asn Gln Glu Glu  Gln Ser Met 
    1805                 1810                 1815             


Asp Ser  Asn Leu Gly Glu Ala  Ala Ser Gly Cys Glu  Ser Glu Thr 
    1820                 1825                 1830             


Ser Val  Ser Glu Asp Cys Ser  Gly Leu Ser Ser Gln  Ser Asp Ile 
    1835                 1840                 1845             


Leu Thr  Thr Gln Gln Arg Asp  Thr Met Gln His Asn  Leu Ile Lys 
    1850                 1855                 1860             


Leu Gln  Gln Glu Met Ala Glu  Leu Glu Ala Val Leu  Glu Gln His 
    1865                 1870                 1875             


Gly Ser  Gln Pro Ser Asn Ser  Tyr Pro Ser Ile Ile  Ser Asp Ser 
    1880                 1885                 1890             


Ser Ala  Leu Glu Asp Leu Arg  Asn Pro Glu Gln Ser  Thr Ser Glu 
    1895                 1900                 1905             


Lys Ala  Val Leu Thr Ser Gln  Lys Ser Ser Glu Tyr  Pro Ile Ser 
    1910                 1915                 1920             


Gln Asn  Pro Glu Gly Leu Ser  Ala Asp Lys Phe Glu  Val Ser Ala 
    1925                 1930                 1935             


Asp Ser  Ser Thr Ser Lys Asn  Lys Glu Pro Gly Val  Glu Arg Ser 
    1940                 1945                 1950             


Ser Pro  Ser Lys Cys Pro Ser  Leu Asp Asp Arg Trp  Tyr Met His 
    1955                 1960                 1965             


Ser Cys  Ser Gly Ser Leu Gln  Asn Arg Asn Tyr Pro  Ser Gln Glu 
    1970                 1975                 1980             


Glu Leu  Ile Lys Val Val Asp  Val Glu Glu Gln Gln  Leu Glu Glu 
    1985                 1990                 1995             


Ser Gly  Pro His Asp Leu Thr  Glu Thr Ser Tyr Leu  Pro Arg Gln 
    2000                 2005                 2010             


Asp Leu  Glu Gly Thr Pro Tyr  Leu Glu Ser Gly Ile  Ser Leu Phe 
    2015                 2020                 2025             


Ser Asp  Asp Pro Glu Ser Asp  Pro Ser Glu Asp Arg  Ala Pro Glu 
    2030                 2035                 2040             


Ser Ala  Arg Val Gly Asn Ile  Pro Ser Ser Thr Ser  Ala Leu Lys 
    2045                 2050                 2055             


Val Pro  Gln Leu Lys Val Ala  Glu Ser Ala Gln Gly  Pro Ala Ala 
    2060                 2065                 2070             


Ala His  Thr Thr Asp Thr Ala  Gly Tyr Asn Ala Met  Glu Glu Ser 
    2075                 2080                 2085             


Val Ser  Arg Glu Lys Pro Glu  Leu Thr Ala Ser Thr  Glu Arg Val 
    2090                 2095                 2100             


Asn Lys  Arg Met Ser Met Val  Val Ser Gly Leu Thr  Pro Glu Glu 
    2105                 2110                 2115             


Phe Met  Leu Val Tyr Lys Phe  Ala Arg Lys His His  Ile Thr Leu 
    2120                 2125                 2130             


Thr Asn  Leu Ile Thr Glu Glu  Thr Thr His Val Val  Met Lys Thr 
    2135                 2140                 2145             


Asp Ala  Glu Phe Val Cys Glu  Arg Thr Leu Lys Tyr  Phe Leu Gly 
    2150                 2155                 2160             


Ile Ala  Gly Gly Lys Trp Val  Val Ser Tyr Phe Trp  Val Thr Gln 
    2165                 2170                 2175             


Ser Ile  Lys Glu Arg Lys Met  Leu Asn Glu His Asp  Phe Glu Val 
    2180                 2185                 2190             


Arg Gly  Asp Val Val Asn Gly  Arg Asn His Gln Gly  Pro Lys Arg 
    2195                 2200                 2205             


Ala Arg  Glu Ser Gln Asp Arg  Lys Ile Phe Arg Gly  Leu Glu Ile 
    2210                 2215                 2220             


Cys Cys  Tyr Gly Pro Phe Thr  Asn Met Pro Thr Asp  Gln Leu Glu 
    2225                 2230                 2235             


Trp Met  Val Gln Leu Cys Gly  Ala Ser Val Val Lys  Glu Leu Ser 
    2240                 2245                 2250             


Ser Phe  Thr Leu Gly Thr Gly  Val His Pro Ile Val  Val Val Gln 
    2255                 2260                 2265             


Pro Asp  Ala Trp Thr Glu Asp  Asn Gly Phe His Ala  Ile Gly Gln 
    2270                 2275                 2280             


Met Cys  Glu Ala Pro Val Val  Thr Arg Glu Trp Val  Leu Asp Ser 
    2285                 2290                 2295             


Val Ala  Leu Tyr Gln Cys Gln  Glu Leu Asp Thr Tyr  Leu Ile Pro 
    2300                 2305                 2310             


Gln Ile  Pro His Ser His Tyr  Ile Asp 
    2315                 2320         


<210>  43
<211>  6647
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide

<400>  43
tcaatattgg ccattagcca tattattcat tggttatata gcataaatca atattggcta       60

ttggccattg catacgttgt atctatatca taatatgtac atttatattg gctcatgtcc      120

aatatgaccg ccatgttggc attgattatt gactagttat taatagtaat caattacggg      180

gtcattagtt catagcccat atatggagtt ccgcgttaca taacttacgg taaatggccc      240

gcctggctga ccgcccaacg acccccgccc attgacgtca ataatgacgt atgttcccat      300

agtaacgcca atagggactt tccattgacg tcaatgggtg gagtatttac ggtaaactgc      360

ccacttggca gtacatcaag tgtatcatat gccaagtccg ccccctattg acgtcaatga      420

cggtaaatgg cccgcctggc attatgccca gtacatgacc ttacgggact ttcctacttg      480

gcagtacatc tacgtattag tcatcgctat taccatggtg atgcggtttt ggcagtacac      540

caatgggcgt ggatagcggt ttgactcacg gggatttcca agtctccacc ccattgacgt      600

caatgggagt ttgttttggc accaaaatca acgggacttt ccaaaatgtc gtaataaccc      660

cgccccgttg acgcaaatgg gcggtaggcg tgtacggtgg gaggtctata taagcagagg      720

tcgtttagtg aaccgtcaga tcactagtag ctttattgcg gtagtttatc acagttaaat      780

tgctaacgca gtcagtgctc gactgatcac aggtaagtat caaggttaca agacaggttt      840

aaggaggcca atagaaactg ggcttgtcga gacagagaag attcttgcgt ttctgatagg      900

cacctattgg tcttactgac atccactttg cctttctctc cacagggaaa aaacaattga      960

caagtttgta caaaaaagca ggctccgaat tcaccggtgc cgccaccatg gggccggcca     1020

tgaggaggag cttggctccc agccagctgg ccaagagaaa acctgaaggc aggtcctgtg     1080

atgatgaaga ctggcaacct ggcctagtga ctcctaggaa acggaaatcc agcagtgaga     1140

cccagatcca ggagtgtttc ctgtctcctt ttcggaaacc tttgagtcag ctaaccaatc     1200

aaccaccttg tctggacagc agtcagcatg aagcatttat tcgaagcatt ttgtcaaagc     1260

ctttcaaagt ccccattcca aattatcaag gtcctctggg ctctcgagca ttgggcctga     1320

aaagggctgg ggtccgccgg gccctccatg accccctgga aaaagatgcc ttggttctgt     1380

atgagcctcc cccgctgagc gctcatgacc agctgaagct tgacaaggag aaactccctg     1440

tccatgtggt tgttgaccct attctcagta aggttttgcg gcctcatcag agagagggag     1500

tgaaattcct gtgggagtgt gtcaccagtc ggcgcatccc tggcagccat ggctgcatca     1560

tggctgatga gatgggccta ggaaagacgc tgcagtgcat cacattgatg tggacacttt     1620

tacgccagag tccagagtgc aagccagaaa ttgacaaggc agtggtggtg tcgccttcca     1680

gcctggtgaa gaactggtac aatgaggttg ggaaatggct cggagggagg atccaacctc     1740

tggccatcga tggaggatct aaggatgaaa tagaccaaaa gctggaagga ttcatgaacc     1800

agcgtggagc cagggtgtct tctcccatcc tcatcatttc ctatgagacc ttccgccttc     1860

atgttggagt cctccagaaa ggaagtgttg gtctggtcat atgtgacgag ggacacaggc     1920

tcaagaactc tgagaatcag acttaccaag ccctggacag cttgaacacc agccggcggg     1980

tgctcatctc cggaactccc atccagaatg atctgcttga gtatttcagc ttggtacatt     2040

ttgttaattc cggcatccta gggactgccc atgaattcaa gaagcatttt gaattgccaa     2100

ttttgaaggg tcgagacgct gctgctagtg aggcagacag gcagctagga gaggagcggc     2160

tgcgggagct caccagcatt gtgaatagat gcctgatacg gaggacttct gatatccttt     2220

ctaaatatct gcctgtgaag attgagcagg tcgtttgttg taggctgaca ccccttcaga     2280

ctgagttata caagaggttt ctgagacaag ccaaaccggc agaagaattg cttgagggca     2340

agatgagtgt gtcttccctt tcttccatca cctcgctaaa gaagctttgt aatcatccag     2400

ctctaatcta tgataagtgt gtggaagagg aggatggctt tgtgggtgcc ttggacctct     2460

tccctcctgg ttacagctct aaggccctgg agccccagct gtcagtaggg gactgctggt     2520

tgctgctctt cccaggtaag atgctggtcc tggattatat tctggcggtg acccgaagcc     2580

gtagcagtga caaagtagtg ctggtgtcga attacaccca gactttggat ctctttgaga     2640

agctgtgccg tgcccgaagg tacttatacg tccgcctgga tggcacgatg tccattaaga     2700

agcgagccaa ggttgtagaa cgcttcaata gtccatcgag ccctgacttt gtcttcatgc     2760

tgagcagcaa agctgggggc tgtggcctca atctcattgg ggctaaccgg ctggtcatgt     2820

ttgaccctga ctggaaccca gccaatgatg aacaagccat ggcccgggtc tggcgagatg     2880

gtcaaaagaa gacttgctat atctaccgcc tgctgtctgc agggaccatt gaggagaaga     2940

tcttccagcg tcagagccac aagaaggcac tgagcagctg tgtggtggat gaggagcagg     3000

atgtagagcg ccacttctct ctgggcgagt tgaaggagct gtttatcctg gatgaagcta     3060

gcctcagtga cacacatgac aggttgcact gccgacgttg tgtcaacagc cgtcagatcc     3120

ggccaccccc tgatggttct gactgcactt cagacctggc agggtggaac cactgcactg     3180

ataagtgggg gctccgggat gaggtactcc aggctgcctg ggatgctgcc tccactgcca     3240

tcaccttcgt cttccaccag cgttctcatg aggagcagcg gggcctccgc aacgatggcg     3300

gaggcggatc tgatccaaaa aagaagagaa aggtagatcc aaaaaagaag agaaaggtag     3360

atccaaaaaa gaagagaaag gtaggatcta ccggatctag aaacgatggt ggtggtggaa     3420

gcgggggtgg gggcagcggt ggagggggaa gcgggcgcgc cgggatcctc ccccccaaga     3480

aaaagaggaa ggtatctaga ggccgcagcc gccttttgga agattttcga aacaaccggt     3540

accccaattt acaactgcgg gagattgctg gacatataat ggaattttcc caagaccagc     3600

atgggtccag attcattcag ctgaaactgg agcgtgccac accagctgag cgccagcttg     3660

tcttcaatga aatcctccag gctgcctacc aactcatggt ggatgtgttt ggtaattacg     3720

tcattcagaa gttctttgaa tttggcagtc ttgaacagaa gctggctttg gcagaacgga     3780

ttcgaggcca cgtcctgtca ttggcactac agatgtatgg cagccgtgtt atcgagaaag     3840

ctcttgagtt tattccttca gaccagcaga atgagatggt tcgggaacta gatggccatg     3900

tcttgaagtg tgtgaaagat cagaatggca atcacgtggt tcagaaatgc attgaatgtg     3960

tacagcccca gtctttgcaa tttatcatcg acgcgtttaa gggacaggta tttgccttat     4020

ccacacatcc ttatggctgc cgagtgattc agagaatcct ggagcactgt ctccctgacc     4080

agacactccc tattttagag gagcttcacc agcacacaga gcagctggta caggatcaat     4140

atggaaatta tgtaatccaa catgtactgg agcacggtcg tcctgaggat aaaagcaaaa     4200

ttgtagcaga aatccgaggc aatgtacttg tattgagtca gcacaaattt gcaagcaatg     4260

ttgtggagaa gtgtgttact cacgcctcac gtacggagcg cgctgtgctc atcgacgagg     4320

tgtgcaccat gaacgacggt ccccacagtg ccttatacac catgatgaag gaccagtatg     4380

ccaactacgt ggtccagaag atgattgacg tggcggagcc aggccagcgg aagatcgtca     4440

tgcataagat ccggccccac atcgcaactc ttcgtaagta cacctatggc aagcacattc     4500

tggccaagct ggagaagtac tacatgaaga acggtgttga cttaggggac ccaaagaaga     4560

agcgcaaagt ggatcctaaa aagaaaagaa aggtaggcgg ccgcggggga ggcggttccg     4620

gtggcggcgg aagcggaggt ggaggatcag ggccggcctg attaattaag aattcgaccc     4680

agctttcttg tacaaagtgg ttgatatcca gcacagtggc ggccgctcga gtctagaggg     4740

cccgcggttc gaaggtaagc ctatccctaa ccctctcctc ggtctcgatt ctacgcgtac     4800

cggttagcaa ttgttttttc gatgagtttg gacaaaccac aactagaatg cagtgaaaaa     4860

aatgctttat ttgtgaaatt tgtgatgcta ttgctttatt tgtaaccatt ataagctgca     4920

ataaacaagt taacaacaac aattgcattc attttatgtt tcaggttcag ggggaggtgt     4980

gggaggtttt ttaaagcaag taaaacctct acaaatgtgg tacttaagag ggggagacca     5040

aagggcgaga cgttaaggcc tcacgtgaca tgtgagcaaa aggccagcaa aaggccagga     5100

accgtaaaaa ggccgcgttg ctggcgtttt tccataggct ccgcccccct gacgagcatc     5160

acaaaaatcg acgctcaagt cagaggtggc gaaacccgac aggactataa agataccagg     5220

cgtttccccc tggaagctcc ctcgtgcgct ctcctgttcc gaccctgccg cttaccggat     5280

acctgtccgc ctttctccct tcgggaagcg tggcgctttc tcatagctca cgctgtaggt     5340

atctcagttc ggtgtaggtc gttcgctcca agctgggctg tgtgcacgaa ccccccgttc     5400

agcccgaccg ctgcgcctta tccggtaact atcgtcttga gtccaacccg gtaagacacg     5460

acttatcgcc actggcagca gccactggta acaggattag cagagcgagg tatgtaggcg     5520

gtgctacaga gttcttgaag tggtggccta actacggcta cactagaagg acagtatttg     5580

gtatctgcgc tctgctgaag ccagttacct tcggaaaaag agttggtagc tcttgatccg     5640

gcaaacaaac cacgctggta gcggtggttt ttttgtttgc aagcagcaga ttacgcgcag     5700

aaaaaaagga tctcaagaag atcctttgat cttttctacg gggtctgacg ctcagtggaa     5760

cgaaaactca cgttaaggga ttttggtcat gccgtctcag aagaactcgt caagaaggcg     5820

atagaaggcg atgcgctgcg aatcgggagc ggcgataccg taaagcacga ggaagcggtc     5880

agcccattcg ccgccaagct cttcagcaat atcacgggta gccaacgcta tgtcctgata     5940

gcggtccgcc acacccagcc ggccacagtc gatgaatcca gaaaagcggc cattttccac     6000

catgatattc ggcaagcagg catcgccatg ggtcacgacg agatcctcgc cgtcgggcat     6060

gctcgccttg agcctggcga acagttcggc tggcgcgagc ccctgatgct cttcgtccag     6120

atcatcctga tcgacaagac cggcttccat ccgagtacgt gctcgctcga tgcgatgttt     6180

cgcttggtgg tcgaatgggc aggtagccgg atcaagcgta tgcagccgcc gcattgcatc     6240

agccatgatg gatactttct cggcaggagc aaggtgagat gacaggagat cctgccccgg     6300

cacttcgccc aatagcagcc agtcccttcc cgcttcagtg acaacgtcga gcacagctgc     6360

gcaaggaacg cccgtcgtgg ccagccacga tagccgcgct gcctcgtctt gcagttcatt     6420

cagggcaccg gacaggtcgg tcttgacaaa aagaaccggg cgcccctgcg ctgacagccg     6480

gaacacggcg gcatcagagc agccgattgt ctgttgtgcc cagtcatagc cgaatagcct     6540

ctccacccaa gcggccggag aacctgcgtg caatccatct tgttcaatca taatattatt     6600

gaagcattta tcagggttcg tctcgtcccg gtctcctccc atgcatg                   6647


<210>  44
<211>  1217
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  44

Met Gly Pro Ala Met Arg Arg Ser Leu Ala Pro Ser Gln Leu Ala Lys 
1               5                   10                  15      


Arg Lys Pro Glu Gly Arg Ser Cys Asp Asp Glu Asp Trp Gln Pro Gly 
            20                  25                  30          


Leu Val Thr Pro Arg Lys Arg Lys Ser Ser Ser Glu Thr Gln Ile Gln 
        35                  40                  45              


Glu Cys Phe Leu Ser Pro Phe Arg Lys Pro Leu Ser Gln Leu Thr Asn 
    50                  55                  60                  


Gln Pro Pro Cys Leu Asp Ser Ser Gln His Glu Ala Phe Ile Arg Ser 
65                  70                  75                  80  


Ile Leu Ser Lys Pro Phe Lys Val Pro Ile Pro Asn Tyr Gln Gly Pro 
                85                  90                  95      


Leu Gly Ser Arg Ala Leu Gly Leu Lys Arg Ala Gly Val Arg Arg Ala 
            100                 105                 110         


Leu His Asp Pro Leu Glu Lys Asp Ala Leu Val Leu Tyr Glu Pro Pro 
        115                 120                 125             


Pro Leu Ser Ala His Asp Gln Leu Lys Leu Asp Lys Glu Lys Leu Pro 
    130                 135                 140                 


Val His Val Val Val Asp Pro Ile Leu Ser Lys Val Leu Arg Pro His 
145                 150                 155                 160 


Gln Arg Glu Gly Val Lys Phe Leu Trp Glu Cys Val Thr Ser Arg Arg 
                165                 170                 175     


Ile Pro Gly Ser His Gly Cys Ile Met Ala Asp Glu Met Gly Leu Gly 
            180                 185                 190         


Lys Thr Leu Gln Cys Ile Thr Leu Met Trp Thr Leu Leu Arg Gln Ser 
        195                 200                 205             


Pro Glu Cys Lys Pro Glu Ile Asp Lys Ala Val Val Val Ser Pro Ser 
    210                 215                 220                 


Ser Leu Val Lys Asn Trp Tyr Asn Glu Val Gly Lys Trp Leu Gly Gly 
225                 230                 235                 240 


Arg Ile Gln Pro Leu Ala Ile Asp Gly Gly Ser Lys Asp Glu Ile Asp 
                245                 250                 255     


Gln Lys Leu Glu Gly Phe Met Asn Gln Arg Gly Ala Arg Val Ser Ser 
            260                 265                 270         


Pro Ile Leu Ile Ile Ser Tyr Glu Thr Phe Arg Leu His Val Gly Val 
        275                 280                 285             


Leu Gln Lys Gly Ser Val Gly Leu Val Ile Cys Asp Glu Gly His Arg 
    290                 295                 300                 


Leu Lys Asn Ser Glu Asn Gln Thr Tyr Gln Ala Leu Asp Ser Leu Asn 
305                 310                 315                 320 


Thr Ser Arg Arg Val Leu Ile Ser Gly Thr Pro Ile Gln Asn Asp Leu 
                325                 330                 335     


Leu Glu Tyr Phe Ser Leu Val His Phe Val Asn Ser Gly Ile Leu Gly 
            340                 345                 350         


Thr Ala His Glu Phe Lys Lys His Phe Glu Leu Pro Ile Leu Lys Gly 
        355                 360                 365             


Arg Asp Ala Ala Ala Ser Glu Ala Asp Arg Gln Leu Gly Glu Glu Arg 
    370                 375                 380                 


Leu Arg Glu Leu Thr Ser Ile Val Asn Arg Cys Leu Ile Arg Arg Thr 
385                 390                 395                 400 


Ser Asp Ile Leu Ser Lys Tyr Leu Pro Val Lys Ile Glu Gln Val Val 
                405                 410                 415     


Cys Cys Arg Leu Thr Pro Leu Gln Thr Glu Leu Tyr Lys Arg Phe Leu 
            420                 425                 430         


Arg Gln Ala Lys Pro Ala Glu Glu Leu Leu Glu Gly Lys Met Ser Val 
        435                 440                 445             


Ser Ser Leu Ser Ser Ile Thr Ser Leu Lys Lys Leu Cys Asn His Pro 
    450                 455                 460                 


Ala Leu Ile Tyr Asp Lys Cys Val Glu Glu Glu Asp Gly Phe Val Gly 
465                 470                 475                 480 


Ala Leu Asp Leu Phe Pro Pro Gly Tyr Ser Ser Lys Ala Leu Glu Pro 
                485                 490                 495     


Gln Leu Ser Val Gly Asp Cys Trp Leu Leu Leu Phe Pro Gly Lys Met 
            500                 505                 510         


Leu Val Leu Asp Tyr Ile Leu Ala Val Thr Arg Ser Arg Ser Ser Asp 
        515                 520                 525             


Lys Val Val Leu Val Ser Asn Tyr Thr Gln Thr Leu Asp Leu Phe Glu 
    530                 535                 540                 


Lys Leu Cys Arg Ala Arg Arg Tyr Leu Tyr Val Arg Leu Asp Gly Thr 
545                 550                 555                 560 


Met Ser Ile Lys Lys Arg Ala Lys Val Val Glu Arg Phe Asn Ser Pro 
                565                 570                 575     


Ser Ser Pro Asp Phe Val Phe Met Leu Ser Ser Lys Ala Gly Gly Cys 
            580                 585                 590         


Gly Leu Asn Leu Ile Gly Ala Asn Arg Leu Val Met Phe Asp Pro Asp 
        595                 600                 605             


Trp Asn Pro Ala Asn Asp Glu Gln Ala Met Ala Arg Val Trp Arg Asp 
    610                 615                 620                 


Gly Gln Lys Lys Thr Cys Tyr Ile Tyr Arg Leu Leu Ser Ala Gly Thr 
625                 630                 635                 640 


Ile Glu Glu Lys Ile Phe Gln Arg Gln Ser His Lys Lys Ala Leu Ser 
                645                 650                 655     


Ser Cys Val Val Asp Glu Glu Gln Asp Val Glu Arg His Phe Ser Leu 
            660                 665                 670         


Gly Glu Leu Lys Glu Leu Phe Ile Leu Asp Glu Ala Ser Leu Ser Asp 
        675                 680                 685             


Thr His Asp Arg Leu His Cys Arg Arg Cys Val Asn Ser Arg Gln Ile 
    690                 695                 700                 


Arg Pro Pro Pro Asp Gly Ser Asp Cys Thr Ser Asp Leu Ala Gly Trp 
705                 710                 715                 720 


Asn His Cys Thr Asp Lys Trp Gly Leu Arg Asp Glu Val Leu Gln Ala 
                725                 730                 735     


Ala Trp Asp Ala Ala Ser Thr Ala Ile Thr Phe Val Phe His Gln Arg 
            740                 745                 750         


Ser His Glu Glu Gln Arg Gly Leu Arg Asn Asp Gly Gly Gly Gly Ser 
        755                 760                 765             


Asp Pro Lys Lys Lys Arg Lys Val Asp Pro Lys Lys Lys Arg Lys Val 
    770                 775                 780                 


Asp Pro Lys Lys Lys Arg Lys Val Gly Ser Thr Gly Ser Arg Asn Asp 
785                 790                 795                 800 


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
                805                 810                 815     


Arg Ala Gly Ile Leu Pro Pro Lys Lys Lys Arg Lys Val Ser Arg Gly 
            820                 825                 830         


Arg Ser Arg Leu Leu Glu Asp Phe Arg Asn Asn Arg Tyr Pro Asn Leu 
        835                 840                 845             


Gln Leu Arg Glu Ile Ala Gly His Ile Met Glu Phe Ser Gln Asp Gln 
    850                 855                 860                 


His Gly Ser Arg Phe Ile Gln Leu Lys Leu Glu Arg Ala Thr Pro Ala 
865                 870                 875                 880 


Glu Arg Gln Leu Val Phe Asn Glu Ile Leu Gln Ala Ala Tyr Gln Leu 
                885                 890                 895     


Met Val Asp Val Phe Gly Asn Tyr Val Ile Gln Lys Phe Phe Glu Phe 
            900                 905                 910         


Gly Ser Leu Glu Gln Lys Leu Ala Leu Ala Glu Arg Ile Arg Gly His 
        915                 920                 925             


Val Leu Ser Leu Ala Leu Gln Met Tyr Gly Ser Arg Val Ile Glu Lys 
    930                 935                 940                 


Ala Leu Glu Phe Ile Pro Ser Asp Gln Gln Asn Glu Met Val Arg Glu 
945                 950                 955                 960 


Leu Asp Gly His Val Leu Lys Cys Val Lys Asp Gln Asn Gly Asn His 
                965                 970                 975     


Val Val Gln Lys Cys Ile Glu Cys Val Gln Pro Gln Ser Leu Gln Phe 
            980                 985                 990         


Ile Ile Asp Ala Phe Lys Gly Gln  Val Phe Ala Leu Ser  Thr His Pro 
        995                 1000                 1005             


Tyr Gly  Cys Arg Val Ile Gln  Arg Ile Leu Glu His  Cys Leu Pro 
    1010                 1015                 1020             


Asp Gln  Thr Leu Pro Ile Leu  Glu Glu Leu His Gln  His Thr Glu 
    1025                 1030                 1035             


Gln Leu  Val Gln Asp Gln Tyr  Gly Asn Tyr Val Ile  Gln His Val 
    1040                 1045                 1050             


Leu Glu  His Gly Arg Pro Glu  Asp Lys Ser Lys Ile  Val Ala Glu 
    1055                 1060                 1065             


Ile Arg  Gly Asn Val Leu Val  Leu Ser Gln His Lys  Phe Ala Ser 
    1070                 1075                 1080             


Asn Val  Val Glu Lys Cys Val  Thr His Ala Ser Arg  Thr Glu Arg 
    1085                 1090                 1095             


Ala Val  Leu Ile Asp Glu Val  Cys Thr Met Asn Asp  Gly Pro His 
    1100                 1105                 1110             


Ser Ala  Leu Tyr Thr Met Met  Lys Asp Gln Tyr Ala  Asn Tyr Val 
    1115                 1120                 1125             


Val Gln  Lys Met Ile Asp Val  Ala Glu Pro Gly Gln  Arg Lys Ile 
    1130                 1135                 1140             


Val Met  His Lys Ile Arg Pro  His Ile Ala Thr Leu  Arg Lys Tyr 
    1145                 1150                 1155             


Thr Tyr  Gly Lys His Ile Leu  Ala Lys Leu Glu Lys  Tyr Tyr Met 
    1160                 1165                 1170             


Lys Asn  Gly Val Asp Leu Gly  Asp Pro Lys Lys Lys  Arg Lys Val 
    1175                 1180                 1185             


Asp Pro  Lys Lys Lys Arg Lys  Val Gly Gly Arg Gly  Gly Gly Gly 
    1190                 1195                 1200             


Ser Gly  Gly Gly Gly Ser Gly  Gly Gly Gly Ser Gly  Pro Ala 
    1205                 1210                 1215         


<210>  45
<211>  7067
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide

<400>  45
tcaatattgg ccattagcca tattattcat tggttatata gcataaatca atattggcta       60

ttggccattg catacgttgt atctatatca taatatgtac atttatattg gctcatgtcc      120

aatatgaccg ccatgttggc attgattatt gactagttat taatagtaat caattacggg      180

gtcattagtt catagcccat atatggagtt ccgcgttaca taacttacgg taaatggccc      240

gcctggctga ccgcccaacg acccccgccc attgacgtca ataatgacgt atgttcccat      300

agtaacgcca atagggactt tccattgacg tcaatgggtg gagtatttac ggtaaactgc      360

ccacttggca gtacatcaag tgtatcatat gccaagtccg ccccctattg acgtcaatga      420

cggtaaatgg cccgcctggc attatgccca gtacatgacc ttacgggact ttcctacttg      480

gcagtacatc tacgtattag tcatcgctat taccatggtg atgcggtttt ggcagtacac      540

caatgggcgt ggatagcggt ttgactcacg gggatttcca agtctccacc ccattgacgt      600

caatgggagt ttgttttggc accaaaatca acgggacttt ccaaaatgtc gtaataaccc      660

cgccccgttg acgcaaatgg gcggtaggcg tgtacggtgg gaggtctata taagcagagg      720

tcgtttagtg aaccgtcaga tcactagtag ctttattgcg gtagtttatc acagttaaat      780

tgctaacgca gtcagtgctc gactgatcac aggtaagtat caaggttaca agacaggttt      840

aaggaggcca atagaaactg ggcttgtcga gacagagaag attcttgcgt ttctgatagg      900

cacctattgg tcttactgac atccactttg cctttctctc cacagggaaa aaacaattga      960

caagtttgta caaaaaagca ggctccgaat tcaccggtgc cgccaccatg gggccggcca     1020

tgaacatctc gggaagcagc tgtggaagcc ctaactctgc agatacatct agtgacttta     1080

aggacctttg gacaaaacta aaagaatgtc atgatagaga agtacaaggt ttacaagtaa     1140

aagtaaccaa gctaaaacag gaacgaatct tagatgcaca aagactagaa gaattcttca     1200

ccaaaaatca acagctgagg gaacagcaga aagtccttca tgaaaccatt aaagttttag     1260

aagatcggtt aagagcaggc ttatgtgatc gctgtgcagt aactgaagaa catatgcgga     1320

aaaaacagca agagtttgaa aatatccggc agcagaatct taaacttatt acagaactta     1380

tgaatgaaag gaatactcta caggaagaaa ataaaaagct ttctgaacaa ctccagcaga     1440

aaattgagaa tgatcaacag catcaagcag ctgagcttga atgtgaggaa gacgttattc     1500

cagattcacc gataacagcc ttctcatttt ctggcgttaa ccggctacga agaaaggaga     1560

acccccatgt ccgatacata gaacaaacac atactaaatt ggagcactct gtgtgtgcaa     1620

atgaaatgag aaaagtttcc aagtcttcaa ctcatccaca acataatcct aatgaaaatg     1680

aaattctagt agctgacact tatgaccaaa gtcaatctcc aatggccaaa gcacatggaa     1740

caagcagcta tacccctgat aagtcatctt ttaatttagc tacagttgtt gctgaaacac     1800

ttggacttgg tgttcaagaa gaatctgaaa ctcaaggtcc catgagcccc cttggtgatg     1860

agctctacca ctgtctggaa ggaaatcaca agaaacagcc ttttgaggaa tctacaagaa     1920

atactgaaga tagtttaaga ttttcagatt ctacttcaaa gactcctcct caagaagaat     1980

tacctactcg agtgtcatct cctgtatttg gagctacctc tagtatcaaa agtggtttag     2040

atttgaatac aagtttgtcc ccttctcttt tacagcctgg gaaaaaaaaa catctgaaaa     2100

cactcccttt tagcaacact tgtatatcta gattagaaaa aactagatca aaatctgaag     2160

atagtgccct tttcacacat cacagtcttg ggtctgaagt gaacaagatc attatccagt     2220

catctaataa acagatactt ataaataaaa atataagtga atccctaggt gaacagaata     2280

ggactgagta cggtaaagat tctaacactg ataaacattt ggagcccctg aaatcattgg     2340

gaggccgaac atccaaaagg aagaaaactg aggaagaaag tgaacatgaa gtaagctgcc     2400

cccaagcttc ttttgataaa gaaaatgctt tcccttttcc aatggataat cagttttcca     2460

tgaatggaga ctgtgtgatg gataaacctc tggatctgtc tgatcgattt tcagctattc     2520

agcgtcaaga gaaaagccaa ggaagtgaga cttctaaaaa caaatttagg caagtgactc     2580

tttatgaggc tttgaagacc attccaaagg gcttttcctc aagccgtaag gcctcagatg     2640

gcaactgcac gttgcccaaa gattccccag gggagccctg ttcacaggaa tgcatcatcc     2700

ttcagccctt gaataaatgc tctccagaca ataaaccatc attacaaata aaagaagaaa     2760

atgctgtctt taaaattcct ctacgtccac gtgaaagttt ggagactgag aatgttttag     2820

atgacataaa gagtgctggt tctcatgagc caataaaaat acaaaccagg tcagaccatg     2880

gaggatgtga acttgcatca gttcttcagt taaatccatg tagaactggt aaaataaagt     2940

ctctacaaaa caaccaagat gtatcctttg aaaatatcca gtggagtata gatccgggag     3000

cagacctttc tcagtataaa atggatgtta ctgtaataga tacaaaggat ggcagtcagt     3060

caaaattagg aggagagaca gtggacatgg actgtacatt ggttagtgaa accgttctct     3120

taaaaatgaa gaagcaagag cagaagggag aaaaaagttc aaatgaagaa agaaaaatga     3180

atgatagctt ggaagatatg tttgatcgga caacacatga agagtatgaa tcctgtttgg     3240

cagacagttt ctcccaagca gcagatgaag aggaggaatt gtctactgcc acaaagaaac     3300

tacacactca tggtgataaa caagacaaag tcaagcagaa agcgtttgtg gagccgtatt     3360

ttaaaggtga tgaaagagag actagcttgc aaaattttcc tcatattgag gtggttcgga     3420

aaaaagagga gagaagaaaa ctgcttgggc acacgtgtaa ggaatgtgaa atttattatg     3480

cagatatgcc agcagaagaa agagaaaaga aattggcttc ctgctcaaga caccgattcc     3540

gctacattcc acccaacgag ccagagaatt tttgggaagt tggttttcct tccactcaga     3600

cttgtatgga aagaggttat attaaggaag atcttgatcc ttgtcctcgt ccaaaaagac     3660

gtcagcctta caacgcaata ttttctccaa aaggcaagga gcagaagaca aacgatggcg     3720

gaggcggatc tgatccaaaa aagaagagaa aggtagatcc aaaaaagaag agaaaggtag     3780

atccaaaaaa gaagagaaag gtaggatcta ccggatctag aaacgatggt ggtggtggaa     3840

gcgggggtgg gggcagcggt ggagggggaa gcgggcgcgc cgggatcctc ccccccaaga     3900

aaaagaggaa ggtatctaga ggccgcagcc gccttttgga agattttcga aacaaccggt     3960

accccaattt acaactgcgg gagattgctg gacatataat ggaattttcc caagaccagc     4020

atgggtccag attcattcag ctgaaactgg agcgtgccac accagctgag cgccagcttg     4080

tcttcaatga aatcctccag gctgcctacc aactcatggt ggatgtgttt ggtaattacg     4140

tcattcagaa gttctttgaa tttggcagtc ttgaacagaa gctggctttg gcagaacgga     4200

ttcgaggcca cgtcctgtca ttggcactac agatgtatgg cagccgtgtt atcgagaaag     4260

ctcttgagtt tattccttca gaccagcaga atgagatggt tcgggaacta gatggccatg     4320

tcttgaagtg tgtgaaagat cagaatggca atcacgtggt tcagaaatgc attgaatgtg     4380

tacagcccca gtctttgcaa tttatcatcg acgcgtttaa gggacaggta tttgccttat     4440

ccacacatcc ttatggctgc cgagtgattc agagaatcct ggagcactgt ctccctgacc     4500

agacactccc tattttagag gagcttcacc agcacacaga gcagctggta caggatcaat     4560

atggaaatta tgtaatccaa catgtactgg agcacggtcg tcctgaggat aaaagcaaaa     4620

ttgtagcaga aatccgaggc aatgtacttg tattgagtca gcacaaattt gcaagcaatg     4680

ttgtggagaa gtgtgttact cacgcctcac gtacggagcg cgctgtgctc atcgacgagg     4740

tgtgcaccat gaacgacggt ccccacagtg ccttatacac catgatgaag gaccagtatg     4800

ccaactacgt ggtccagaag atgattgacg tggcggagcc aggccagcgg aagatcgtca     4860

tgcataagat ccggccccac atcgcaactc ttcgtaagta cacctatggc aagcacattc     4920

tggccaagct ggagaagtac tacatgaaga acggtgttga cttaggggac ccaaagaaga     4980

agcgcaaagt ggatcctaaa aagaaaagaa aggtaggcgg ccgcggggga ggcggttccg     5040

gtggcggcgg aagcggaggt ggaggatcag ggccggcctg attaattaag aattcgaccc     5100

agctttcttg tacaaagtgg ttgatatcca gcacagtggc ggccgctcga gtctagaggg     5160

cccgcggttc gaaggtaagc ctatccctaa ccctctcctc ggtctcgatt ctacgcgtac     5220

cggttagcaa ttgttttttc gatgagtttg gacaaaccac aactagaatg cagtgaaaaa     5280

aatgctttat ttgtgaaatt tgtgatgcta ttgctttatt tgtaaccatt ataagctgca     5340

ataaacaagt taacaacaac aattgcattc attttatgtt tcaggttcag ggggaggtgt     5400

gggaggtttt ttaaagcaag taaaacctct acaaatgtgg tacttaagag ggggagacca     5460

aagggcgaga cgttaaggcc tcacgtgaca tgtgagcaaa aggccagcaa aaggccagga     5520

accgtaaaaa ggccgcgttg ctggcgtttt tccataggct ccgcccccct gacgagcatc     5580

acaaaaatcg acgctcaagt cagaggtggc gaaacccgac aggactataa agataccagg     5640

cgtttccccc tggaagctcc ctcgtgcgct ctcctgttcc gaccctgccg cttaccggat     5700

acctgtccgc ctttctccct tcgggaagcg tggcgctttc tcatagctca cgctgtaggt     5760

atctcagttc ggtgtaggtc gttcgctcca agctgggctg tgtgcacgaa ccccccgttc     5820

agcccgaccg ctgcgcctta tccggtaact atcgtcttga gtccaacccg gtaagacacg     5880

acttatcgcc actggcagca gccactggta acaggattag cagagcgagg tatgtaggcg     5940

gtgctacaga gttcttgaag tggtggccta actacggcta cactagaagg acagtatttg     6000

gtatctgcgc tctgctgaag ccagttacct tcggaaaaag agttggtagc tcttgatccg     6060

gcaaacaaac cacgctggta gcggtggttt ttttgtttgc aagcagcaga ttacgcgcag     6120

aaaaaaagga tctcaagaag atcctttgat cttttctacg gggtctgacg ctcagtggaa     6180

cgaaaactca cgttaaggga ttttggtcat gccgtctcag aagaactcgt caagaaggcg     6240

atagaaggcg atgcgctgcg aatcgggagc ggcgataccg taaagcacga ggaagcggtc     6300

agcccattcg ccgccaagct cttcagcaat atcacgggta gccaacgcta tgtcctgata     6360

gcggtccgcc acacccagcc ggccacagtc gatgaatcca gaaaagcggc cattttccac     6420

catgatattc ggcaagcagg catcgccatg ggtcacgacg agatcctcgc cgtcgggcat     6480

gctcgccttg agcctggcga acagttcggc tggcgcgagc ccctgatgct cttcgtccag     6540

atcatcctga tcgacaagac cggcttccat ccgagtacgt gctcgctcga tgcgatgttt     6600

cgcttggtgg tcgaatgggc aggtagccgg atcaagcgta tgcagccgcc gcattgcatc     6660

agccatgatg gatactttct cggcaggagc aaggtgagat gacaggagat cctgccccgg     6720

cacttcgccc aatagcagcc agtcccttcc cgcttcagtg acaacgtcga gcacagctgc     6780

gcaaggaacg cccgtcgtgg ccagccacga tagccgcgct gcctcgtctt gcagttcatt     6840

cagggcaccg gacaggtcgg tcttgacaaa aagaaccggg cgcccctgcg ctgacagccg     6900

gaacacggcg gcatcagagc agccgattgt ctgttgtgcc cagtcatagc cgaatagcct     6960

ctccacccaa gcggccggag aacctgcgtg caatccatct tgttcaatca taatattatt     7020

gaagcattta tcagggttcg tctcgtcccg gtctcctccc atgcatg                   7067


<210>  46
<211>  1357
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  46

Met Gly Pro Ala Met Asn Ile Ser Gly Ser Ser Cys Gly Ser Pro Asn 
1               5                   10                  15      


Ser Ala Asp Thr Ser Ser Asp Phe Lys Asp Leu Trp Thr Lys Leu Lys 
            20                  25                  30          


Glu Cys His Asp Arg Glu Val Gln Gly Leu Gln Val Lys Val Thr Lys 
        35                  40                  45              


Leu Lys Gln Glu Arg Ile Leu Asp Ala Gln Arg Leu Glu Glu Phe Phe 
    50                  55                  60                  


Thr Lys Asn Gln Gln Leu Arg Glu Gln Gln Lys Val Leu His Glu Thr 
65                  70                  75                  80  


Ile Lys Val Leu Glu Asp Arg Leu Arg Ala Gly Leu Cys Asp Arg Cys 
                85                  90                  95      


Ala Val Thr Glu Glu His Met Arg Lys Lys Gln Gln Glu Phe Glu Asn 
            100                 105                 110         


Ile Arg Gln Gln Asn Leu Lys Leu Ile Thr Glu Leu Met Asn Glu Arg 
        115                 120                 125             


Asn Thr Leu Gln Glu Glu Asn Lys Lys Leu Ser Glu Gln Leu Gln Gln 
    130                 135                 140                 


Lys Ile Glu Asn Asp Gln Gln His Gln Ala Ala Glu Leu Glu Cys Glu 
145                 150                 155                 160 


Glu Asp Val Ile Pro Asp Ser Pro Ile Thr Ala Phe Ser Phe Ser Gly 
                165                 170                 175     


Val Asn Arg Leu Arg Arg Lys Glu Asn Pro His Val Arg Tyr Ile Glu 
            180                 185                 190         


Gln Thr His Thr Lys Leu Glu His Ser Val Cys Ala Asn Glu Met Arg 
        195                 200                 205             


Lys Val Ser Lys Ser Ser Thr His Pro Gln His Asn Pro Asn Glu Asn 
    210                 215                 220                 


Glu Ile Leu Val Ala Asp Thr Tyr Asp Gln Ser Gln Ser Pro Met Ala 
225                 230                 235                 240 


Lys Ala His Gly Thr Ser Ser Tyr Thr Pro Asp Lys Ser Ser Phe Asn 
                245                 250                 255     


Leu Ala Thr Val Val Ala Glu Thr Leu Gly Leu Gly Val Gln Glu Glu 
            260                 265                 270         


Ser Glu Thr Gln Gly Pro Met Ser Pro Leu Gly Asp Glu Leu Tyr His 
        275                 280                 285             


Cys Leu Glu Gly Asn His Lys Lys Gln Pro Phe Glu Glu Ser Thr Arg 
    290                 295                 300                 


Asn Thr Glu Asp Ser Leu Arg Phe Ser Asp Ser Thr Ser Lys Thr Pro 
305                 310                 315                 320 


Pro Gln Glu Glu Leu Pro Thr Arg Val Ser Ser Pro Val Phe Gly Ala 
                325                 330                 335     


Thr Ser Ser Ile Lys Ser Gly Leu Asp Leu Asn Thr Ser Leu Ser Pro 
            340                 345                 350         


Ser Leu Leu Gln Pro Gly Lys Lys Lys His Leu Lys Thr Leu Pro Phe 
        355                 360                 365             


Ser Asn Thr Cys Ile Ser Arg Leu Glu Lys Thr Arg Ser Lys Ser Glu 
    370                 375                 380                 


Asp Ser Ala Leu Phe Thr His His Ser Leu Gly Ser Glu Val Asn Lys 
385                 390                 395                 400 


Ile Ile Ile Gln Ser Ser Asn Lys Gln Ile Leu Ile Asn Lys Asn Ile 
                405                 410                 415     


Ser Glu Ser Leu Gly Glu Gln Asn Arg Thr Glu Tyr Gly Lys Asp Ser 
            420                 425                 430         


Asn Thr Asp Lys His Leu Glu Pro Leu Lys Ser Leu Gly Gly Arg Thr 
        435                 440                 445             


Ser Lys Arg Lys Lys Thr Glu Glu Glu Ser Glu His Glu Val Ser Cys 
    450                 455                 460                 


Pro Gln Ala Ser Phe Asp Lys Glu Asn Ala Phe Pro Phe Pro Met Asp 
465                 470                 475                 480 


Asn Gln Phe Ser Met Asn Gly Asp Cys Val Met Asp Lys Pro Leu Asp 
                485                 490                 495     


Leu Ser Asp Arg Phe Ser Ala Ile Gln Arg Gln Glu Lys Ser Gln Gly 
            500                 505                 510         


Ser Glu Thr Ser Lys Asn Lys Phe Arg Gln Val Thr Leu Tyr Glu Ala 
        515                 520                 525             


Leu Lys Thr Ile Pro Lys Gly Phe Ser Ser Ser Arg Lys Ala Ser Asp 
    530                 535                 540                 


Gly Asn Cys Thr Leu Pro Lys Asp Ser Pro Gly Glu Pro Cys Ser Gln 
545                 550                 555                 560 


Glu Cys Ile Ile Leu Gln Pro Leu Asn Lys Cys Ser Pro Asp Asn Lys 
                565                 570                 575     


Pro Ser Leu Gln Ile Lys Glu Glu Asn Ala Val Phe Lys Ile Pro Leu 
            580                 585                 590         


Arg Pro Arg Glu Ser Leu Glu Thr Glu Asn Val Leu Asp Asp Ile Lys 
        595                 600                 605             


Ser Ala Gly Ser His Glu Pro Ile Lys Ile Gln Thr Arg Ser Asp His 
    610                 615                 620                 


Gly Gly Cys Glu Leu Ala Ser Val Leu Gln Leu Asn Pro Cys Arg Thr 
625                 630                 635                 640 


Gly Lys Ile Lys Ser Leu Gln Asn Asn Gln Asp Val Ser Phe Glu Asn 
                645                 650                 655     


Ile Gln Trp Ser Ile Asp Pro Gly Ala Asp Leu Ser Gln Tyr Lys Met 
            660                 665                 670         


Asp Val Thr Val Ile Asp Thr Lys Asp Gly Ser Gln Ser Lys Leu Gly 
        675                 680                 685             


Gly Glu Thr Val Asp Met Asp Cys Thr Leu Val Ser Glu Thr Val Leu 
    690                 695                 700                 


Leu Lys Met Lys Lys Gln Glu Gln Lys Gly Glu Lys Ser Ser Asn Glu 
705                 710                 715                 720 


Glu Arg Lys Met Asn Asp Ser Leu Glu Asp Met Phe Asp Arg Thr Thr 
                725                 730                 735     


His Glu Glu Tyr Glu Ser Cys Leu Ala Asp Ser Phe Ser Gln Ala Ala 
            740                 745                 750         


Asp Glu Glu Glu Glu Leu Ser Thr Ala Thr Lys Lys Leu His Thr His 
        755                 760                 765             


Gly Asp Lys Gln Asp Lys Val Lys Gln Lys Ala Phe Val Glu Pro Tyr 
    770                 775                 780                 


Phe Lys Gly Asp Glu Arg Glu Thr Ser Leu Gln Asn Phe Pro His Ile 
785                 790                 795                 800 


Glu Val Val Arg Lys Lys Glu Glu Arg Arg Lys Leu Leu Gly His Thr 
                805                 810                 815     


Cys Lys Glu Cys Glu Ile Tyr Tyr Ala Asp Met Pro Ala Glu Glu Arg 
            820                 825                 830         


Glu Lys Lys Leu Ala Ser Cys Ser Arg His Arg Phe Arg Tyr Ile Pro 
        835                 840                 845             


Pro Asn Glu Pro Glu Asn Phe Trp Glu Val Gly Phe Pro Ser Thr Gln 
    850                 855                 860                 


Thr Cys Met Glu Arg Gly Tyr Ile Lys Glu Asp Leu Asp Pro Cys Pro 
865                 870                 875                 880 


Arg Pro Lys Arg Arg Gln Pro Tyr Asn Ala Ile Phe Ser Pro Lys Gly 
                885                 890                 895     


Lys Glu Gln Lys Thr Asn Asp Gly Gly Gly Gly Ser Asp Pro Lys Lys 
            900                 905                 910         


Lys Arg Lys Val Asp Pro Lys Lys Lys Arg Lys Val Asp Pro Lys Lys 
        915                 920                 925             


Lys Arg Lys Val Gly Ser Thr Gly Ser Arg Asn Asp Gly Gly Gly Gly 
    930                 935                 940                 


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Arg Ala Gly Ile 
945                 950                 955                 960 


Leu Pro Pro Lys Lys Lys Arg Lys Val Ser Arg Gly Arg Ser Arg Leu 
                965                 970                 975     


Leu Glu Asp Phe Arg Asn Asn Arg Tyr Pro Asn Leu Gln Leu Arg Glu 
            980                 985                 990         


Ile Ala Gly His Ile Met Glu Phe  Ser Gln Asp Gln His  Gly Ser Arg 
        995                 1000                 1005             


Phe Ile  Gln Leu Lys Leu Glu  Arg Ala Thr Pro Ala  Glu Arg Gln 
    1010                 1015                 1020             


Leu Val  Phe Asn Glu Ile Leu  Gln Ala Ala Tyr Gln  Leu Met Val 
    1025                 1030                 1035             


Asp Val  Phe Gly Asn Tyr Val  Ile Gln Lys Phe Phe  Glu Phe Gly 
    1040                 1045                 1050             


Ser Leu  Glu Gln Lys Leu Ala  Leu Ala Glu Arg Ile  Arg Gly His 
    1055                 1060                 1065             


Val Leu  Ser Leu Ala Leu Gln  Met Tyr Gly Ser Arg  Val Ile Glu 
    1070                 1075                 1080             


Lys Ala  Leu Glu Phe Ile Pro  Ser Asp Gln Gln Asn  Glu Met Val 
    1085                 1090                 1095             


Arg Glu  Leu Asp Gly His Val  Leu Lys Cys Val Lys  Asp Gln Asn 
    1100                 1105                 1110             


Gly Asn  His Val Val Gln Lys  Cys Ile Glu Cys Val  Gln Pro Gln 
    1115                 1120                 1125             


Ser Leu  Gln Phe Ile Ile Asp  Ala Phe Lys Gly Gln  Val Phe Ala 
    1130                 1135                 1140             


Leu Ser  Thr His Pro Tyr Gly  Cys Arg Val Ile Gln  Arg Ile Leu 
    1145                 1150                 1155             


Glu His  Cys Leu Pro Asp Gln  Thr Leu Pro Ile Leu  Glu Glu Leu 
    1160                 1165                 1170             


His Gln  His Thr Glu Gln Leu  Val Gln Asp Gln Tyr  Gly Asn Tyr 
    1175                 1180                 1185             


Val Ile  Gln His Val Leu Glu  His Gly Arg Pro Glu  Asp Lys Ser 
    1190                 1195                 1200             


Lys Ile  Val Ala Glu Ile Arg  Gly Asn Val Leu Val  Leu Ser Gln 
    1205                 1210                 1215             


His Lys  Phe Ala Ser Asn Val  Val Glu Lys Cys Val  Thr His Ala 
    1220                 1225                 1230             


Ser Arg  Thr Glu Arg Ala Val  Leu Ile Asp Glu Val  Cys Thr Met 
    1235                 1240                 1245             


Asn Asp  Gly Pro His Ser Ala  Leu Tyr Thr Met Met  Lys Asp Gln 
    1250                 1255                 1260             


Tyr Ala  Asn Tyr Val Val Gln  Lys Met Ile Asp Val  Ala Glu Pro 
    1265                 1270                 1275             


Gly Gln  Arg Lys Ile Val Met  His Lys Ile Arg Pro  His Ile Ala 
    1280                 1285                 1290             


Thr Leu  Arg Lys Tyr Thr Tyr  Gly Lys His Ile Leu  Ala Lys Leu 
    1295                 1300                 1305             


Glu Lys  Tyr Tyr Met Lys Asn  Gly Val Asp Leu Gly  Asp Pro Lys 
    1310                 1315                 1320             


Lys Lys  Arg Lys Val Asp Pro  Lys Lys Lys Arg Lys  Val Gly Gly 
    1325                 1330                 1335             


Arg Gly  Gly Gly Gly Ser Gly  Gly Gly Gly Ser Gly  Gly Gly Gly 
    1340                 1345                 1350             


Ser Gly  Pro Ala 
    1355         


<210>  47
<211>  7934
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide

<400>  47
tcaatattgg ccattagcca tattattcat tggttatata gcataaatca atattggcta       60

ttggccattg catacgttgt atctatatca taatatgtac atttatattg gctcatgtcc      120

aatatgaccg ccatgttggc attgattatt gactagttat taatagtaat caattacggg      180

gtcattagtt catagcccat atatggagtt ccgcgttaca taacttacgg taaatggccc      240

gcctggctga ccgcccaacg acccccgccc attgacgtca ataatgacgt atgttcccat      300

agtaacgcca atagggactt tccattgacg tcaatgggtg gagtatttac ggtaaactgc      360

ccacttggca gtacatcaag tgtatcatat gccaagtccg ccccctattg acgtcaatga      420

cggtaaatgg cccgcctggc attatgccca gtacatgacc ttacgggact ttcctacttg      480

gcagtacatc tacgtattag tcatcgctat taccatggtg atgcggtttt ggcagtacac      540

caatgggcgt ggatagcggt ttgactcacg gggatttcca agtctccacc ccattgacgt      600

caatgggagt ttgttttggc accaaaatca acgggacttt ccaaaatgtc gtaataaccc      660

cgccccgttg acgcaaatgg gcggtaggcg tgtacggtgg gaggtctata taagcagagg      720

tcgtttagtg aaccgtcaga tcactagtag ctttattgcg gtagtttatc acagttaaat      780

tgctaacgca gtcagtgctc gactgatcac aggtaagtat caaggttaca agacaggttt      840

aaggaggcca atagaaactg ggcttgtcga gacagagaag attcttgcgt ttctgatagg      900

cacctattgg tcttactgac atccactttg cctttctctc cacagggaaa aaacaattga      960

caagtttgta caaaaaagca ggctccgaat tcaccggtgc cgccaccatg gggccggcca     1020

tggacgagcc tcccgggaag cccctcagct gtgaggagag agagagactt cgagagaggc     1080

tcgctttcct tcggcgggag tattcacgaa cacttgcccg attgcaacgg gcgcaaaggg     1140

ccgaacgcat cagacattct attaagaaaa cagtagaaga acaagattgt ttgtctcagc     1200

aggatctctc accgcagcta aaacactcag aacctaaaaa taaaatatgt gtttatgaca     1260

agttacacat caaaacccat cttgatgaag aaactggaga aaagacatct atcacacttg     1320

atgttgggcc tgagtccttt aaccctggag atggcccagg aggattacct atacaaagaa     1380

cagatgacac ccaagaacat tttccccaca gggtcagtga ccctagtggt gagcaaaagc     1440

agaagctgcc aagcagaaga aagaagcagc agaagaggac atttatttca caggagagag     1500

actgtgtctt tggcactgat tcactcagat tgtctgggaa aagactaaag gaacaggaag     1560

aaatcagtag caaaaatcct gctagatcac cagtaactga aataagaact caccttttaa     1620

gtcttaaatc tgaacttcca gattctccag aaccagttac agaaattaat gaagacagtg     1680

tattaattcc accaactgcc caaccagaaa aaggtgttga tacattccta agaagaccta     1740

atttcaccag ggcgactaca gttcctttac agactctatc agatagcggt agtagtcagc     1800

accttgaaca cattcctcct aaaggtagca gtgaacttac tactcacgac ctaaaaaaca     1860

ttagatttac ttcacctgta agtttggagg cacaaggcaa aaaaatgact gtctctacag     1920

ataacctcct tgtaaataaa gctataagta aaagtggcca actgcccaca agttctaatt     1980

tagaggcaaa tatttcatgt tctctaaatg aactcaccta caataactta ccagcaaatg     2040

aaaaccaaaa cttaaaagaa caaaatcaaa cagagaaatc tttaaaatct cccagtgaca     2100

ctcttgatgg caggaatgaa aatcttcagg aaagtgagat tctaagtcaa cctaagagtc     2160

ttagcctgga agcaacctct cctctttctg cagaaaaaca ttcttgcaca gtgcctgaag     2220

gccttctgtt tcctgcagaa tattatgtta gaacaacacg aagcatgtcc aattgccaga     2280

ggaaagtagc cgtggaggct gtcattcaga gtcatttgga tgtcaagaaa aaagggttta     2340

aaaataaaaa taaggatgca agtaaaaatt taaacctttc caatgaggaa actgaccaaa     2400

gtgaaattag gatgtctggc acatgcacag gacaaccaag ttcaagaacc tctcagaaac     2460

ttctctcatt aactaaagtc agctctcccg ctgggcccac tgaagataat gacttgtcta     2520

ggaaggcagt tgcccaagca cctggtagaa gatacacagg aaaaagaaaa tcagcctgca     2580

ccccagcatc agatcattgt gaaccacttt tgccaacttc tagcctgtcg attgttaaca     2640

ggtccaagga agaagtcacc tcacacaaat atcagcacga aaaattattt attcaagtga     2700

aagggaagaa aagtcgtcat caaaaagagg attccctttc ttggagtaat agtgcttatt     2760

tatccttgga tgatgatgct ttcacggctc catttcatag ggatggaatg ctgagtttaa     2820

agcaactact gtcttttctc agtatcacag actttcagtt acctgatgaa gactttggac     2880

ctcttaagct tgaaaaagtg aagtcctgct cagaaaaacc agtggagccc tttgagtcaa     2940

aaatgtttgg agagagacat cttaaagagg gaagctgtat ttttccagag gaactgagtc     3000

ctaaacgcat ggatacagaa atggaggact tagaagagga ccttattgtt ctaccaggaa     3060

aatcacatcc caaaaggcca aactcgcaaa gccagcatac aaagacgggc ctttcttcat     3120

ccatattact ttatactcct ttaaatacgg ttgcgcctga tgataatgac aggcctacca     3180

cagacatgtg ttcacctgct ttccccatct taggtactac tccagccttt ggccctcaag     3240

gctcctatga aaaagcatct acagaagttg ctggacgaac ttgctgcaca ccccaacttg     3300

ctcatttgaa agactcagtc tgtcttgcca gtgatactaa acaattcgac agttcaggca     3360

gcccagcaaa accacatacc accctgcaag tgtcaggcag gcaaggacaa cctacctgtg     3420

actgtgactc tgtcccgcca ggaacacctc cacccattga gtcattcact tttaaagaaa     3480

atcagctctg tagaaacaca tgccaggagc tgcataaaca ttccgtcgaa cagactgaaa     3540

cagcagagct tcctgcttct gatagcataa acccaggcaa cctacaattg gtttcagagt     3600

taaagaatcc ttcaggttcc tgttccgtag atgtgagtgc catgttttgg gaaagagccg     3660

gttgtaaaga gccatgtatc ataactgctt gcgaagatgt agtttctctt tggaaagctc     3720

tggatgcttg gcagtgggaa aaactttata cctggcactt cgcagaggtt ccagtattac     3780

agatagttcc agtgcctgat gtgtataatc tcgtgtgtgt agctttggga aatttggaaa     3840

tcagagagat cagggcattg ttttgttcct ctgatgatga aagtgaaaag caagtactac     3900

tgaagtctgg aaatataaaa gctgtgcttg gcctgacaaa gaggaggcta gttagtagca     3960

gtgggaccct ttctgatcaa caagtagaag tcatgacgtt tgcagaagat ggaggaggca     4020

aagaaaacca atttttgatg ccccctgagg agactatact aacttttgct gaggtccaag     4080

ggatgcaaga agctctgctt ggtactacta ttatgaacaa cattgttatt tggaatttaa     4140

aaactggtca actcctgaaa aagatgcaca ttgatgattc ttaccaagct tcagtctgtc     4200

acaaagccta ttctgaaatg gggcttctct ttattgtcct gagtcatccc tgtgccaaag     4260

agagtgagtc gttgcgaagc cctgtgtttc agctcattgt gattaaccct aagacgactc     4320

tcagcgtggg tgtgatgctg tactgtcttc ctccagggca ggctggcagg ttcctggaag     4380

gtgacgtgaa agatcactgt gcagcagcaa tcttgacttc tggaacaatt gccatttggg     4440

acttacttct cggtcagtgt actgccctcc tcccacctgt ctctgaccaa cattggtctt     4500

ttgtgaaatg gtcgggtaca gactctcatt tgctggctgg acaaaaagat ggaaatatat     4560

ttgtatacca ctattcaaac gatggcggag gcggatctga tccaaaaaag aagagaaagg     4620

tagatccaaa aaagaagaga aaggtagatc caaaaaagaa gagaaaggta ggatctaccg     4680

gatctagaaa cgatggtggt ggtggaagcg ggggtggggg cagcggtgga gggggaagcg     4740

ggcgcgccgg gatcctcccc cccaagaaaa agaggaaggt atctagaggc cgcagccgcc     4800

ttttggaaga ttttcgaaac aaccggtacc ccaatttaca actgcgggag attgctggac     4860

atataatgga attttcccaa gaccagcatg ggtccagatt cattcagctg aaactggagc     4920

gtgccacacc agctgagcgc cagcttgtct tcaatgaaat cctccaggct gcctaccaac     4980

tcatggtgga tgtgtttggt aattacgtca ttcagaagtt ctttgaattt ggcagtcttg     5040

aacagaagct ggctttggca gaacggattc gaggccacgt cctgtcattg gcactacaga     5100

tgtatggcag ccgtgttatc gagaaagctc ttgagtttat tccttcagac cagcagaatg     5160

agatggttcg ggaactagat ggccatgtct tgaagtgtgt gaaagatcag aatggcaatc     5220

acgtggttca gaaatgcatt gaatgtgtac agccccagtc tttgcaattt atcatcgacg     5280

cgtttaaggg acaggtattt gccttatcca cacatcctta tggctgccga gtgattcaga     5340

gaatcctgga gcactgtctc cctgaccaga cactccctat tttagaggag cttcaccagc     5400

acacagagca gctggtacag gatcaatatg gaaattatgt aatccaacat gtactggagc     5460

acggtcgtcc tgaggataaa agcaaaattg tagcagaaat ccgaggcaat gtacttgtat     5520

tgagtcagca caaatttgca agcaatgttg tggagaagtg tgttactcac gcctcacgta     5580

cggagcgcgc tgtgctcatc gacgaggtgt gcaccatgaa cgacggtccc cacagtgcct     5640

tatacaccat gatgaaggac cagtatgcca actacgtggt ccagaagatg attgacgtgg     5700

cggagccagg ccagcggaag atcgtcatgc ataagatccg gccccacatc gcaactcttc     5760

gtaagtacac ctatggcaag cacattctgg ccaagctgga gaagtactac atgaagaacg     5820

gtgttgactt aggggaccca aagaagaagc gcaaagtgga tcctaaaaag aaaagaaagg     5880

taggcggccg cgggggaggc ggttccggtg gcggcggaag cggaggtgga ggatcagggc     5940

cggcctgatt aattaagaat tcgacccagc tttcttgtac aaagtggttg atatccagca     6000

cagtggcggc cgctcgagtc tagagggccc gcggttcgaa ggtaagccta tccctaaccc     6060

tctcctcggt ctcgattcta cgcgtaccgg ttagcaattg ttttttcgat gagtttggac     6120

aaaccacaac tagaatgcag tgaaaaaaat gctttatttg tgaaatttgt gatgctattg     6180

ctttatttgt aaccattata agctgcaata aacaagttaa caacaacaat tgcattcatt     6240

ttatgtttca ggttcagggg gaggtgtggg aggtttttta aagcaagtaa aacctctaca     6300

aatgtggtac ttaagagggg gagaccaaag ggcgagacgt taaggcctca cgtgacatgt     6360

gagcaaaagg ccagcaaaag gccaggaacc gtaaaaaggc cgcgttgctg gcgtttttcc     6420

ataggctccg cccccctgac gagcatcaca aaaatcgacg ctcaagtcag aggtggcgaa     6480

acccgacagg actataaaga taccaggcgt ttccccctgg aagctccctc gtgcgctctc     6540

ctgttccgac cctgccgctt accggatacc tgtccgcctt tctcccttcg ggaagcgtgg     6600

cgctttctca tagctcacgc tgtaggtatc tcagttcggt gtaggtcgtt cgctccaagc     6660

tgggctgtgt gcacgaaccc cccgttcagc ccgaccgctg cgccttatcc ggtaactatc     6720

gtcttgagtc caacccggta agacacgact tatcgccact ggcagcagcc actggtaaca     6780

ggattagcag agcgaggtat gtaggcggtg ctacagagtt cttgaagtgg tggcctaact     6840

acggctacac tagaaggaca gtatttggta tctgcgctct gctgaagcca gttaccttcg     6900

gaaaaagagt tggtagctct tgatccggca aacaaaccac gctggtagcg gtggtttttt     6960

tgtttgcaag cagcagatta cgcgcagaaa aaaaggatct caagaagatc ctttgatctt     7020

ttctacgggg tctgacgctc agtggaacga aaactcacgt taagggattt tggtcatgcc     7080

gtctcagaag aactcgtcaa gaaggcgata gaaggcgatg cgctgcgaat cgggagcggc     7140

gataccgtaa agcacgagga agcggtcagc ccattcgccg ccaagctctt cagcaatatc     7200

acgggtagcc aacgctatgt cctgatagcg gtccgccaca cccagccggc cacagtcgat     7260

gaatccagaa aagcggccat tttccaccat gatattcggc aagcaggcat cgccatgggt     7320

cacgacgaga tcctcgccgt cgggcatgct cgccttgagc ctggcgaaca gttcggctgg     7380

cgcgagcccc tgatgctctt cgtccagatc atcctgatcg acaagaccgg cttccatccg     7440

agtacgtgct cgctcgatgc gatgtttcgc ttggtggtcg aatgggcagg tagccggatc     7500

aagcgtatgc agccgccgca ttgcatcagc catgatggat actttctcgg caggagcaag     7560

gtgagatgac aggagatcct gccccggcac ttcgcccaat agcagccagt cccttcccgc     7620

ttcagtgaca acgtcgagca cagctgcgca aggaacgccc gtcgtggcca gccacgatag     7680

ccgcgctgcc tcgtcttgca gttcattcag ggcaccggac aggtcggtct tgacaaaaag     7740

aaccgggcgc ccctgcgctg acagccggaa cacggcggca tcagagcagc cgattgtctg     7800

ttgtgcccag tcatagccga atagcctctc cacccaagcg gccggagaac ctgcgtgcaa     7860

tccatcttgt tcaatcataa tattattgaa gcatttatca gggttcgtct cgtcccggtc     7920

tcctcccatg catg                                                       7934


<210>  48
<211>  1646
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  48

Met Gly Pro Ala Met Asp Glu Pro Pro Gly Lys Pro Leu Ser Cys Glu 
1               5                   10                  15      


Glu Arg Glu Arg Leu Arg Glu Arg Leu Ala Phe Leu Arg Arg Glu Tyr 
            20                  25                  30          


Ser Arg Thr Leu Ala Arg Leu Gln Arg Ala Gln Arg Ala Glu Arg Ile 
        35                  40                  45              


Arg His Ser Ile Lys Lys Thr Val Glu Glu Gln Asp Cys Leu Ser Gln 
    50                  55                  60                  


Gln Asp Leu Ser Pro Gln Leu Lys His Ser Glu Pro Lys Asn Lys Ile 
65                  70                  75                  80  


Cys Val Tyr Asp Lys Leu His Ile Lys Thr His Leu Asp Glu Glu Thr 
                85                  90                  95      


Gly Glu Lys Thr Ser Ile Thr Leu Asp Val Gly Pro Glu Ser Phe Asn 
            100                 105                 110         


Pro Gly Asp Gly Pro Gly Gly Leu Pro Ile Gln Arg Thr Asp Asp Thr 
        115                 120                 125             


Gln Glu His Phe Pro His Arg Val Ser Asp Pro Ser Gly Glu Gln Lys 
    130                 135                 140                 


Gln Lys Leu Pro Ser Arg Arg Lys Lys Gln Gln Lys Arg Thr Phe Ile 
145                 150                 155                 160 


Ser Gln Glu Arg Asp Cys Val Phe Gly Thr Asp Ser Leu Arg Leu Ser 
                165                 170                 175     


Gly Lys Arg Leu Lys Glu Gln Glu Glu Ile Ser Ser Lys Asn Pro Ala 
            180                 185                 190         


Arg Ser Pro Val Thr Glu Ile Arg Thr His Leu Leu Ser Leu Lys Ser 
        195                 200                 205             


Glu Leu Pro Asp Ser Pro Glu Pro Val Thr Glu Ile Asn Glu Asp Ser 
    210                 215                 220                 


Val Leu Ile Pro Pro Thr Ala Gln Pro Glu Lys Gly Val Asp Thr Phe 
225                 230                 235                 240 


Leu Arg Arg Pro Asn Phe Thr Arg Ala Thr Thr Val Pro Leu Gln Thr 
                245                 250                 255     


Leu Ser Asp Ser Gly Ser Ser Gln His Leu Glu His Ile Pro Pro Lys 
            260                 265                 270         


Gly Ser Ser Glu Leu Thr Thr His Asp Leu Lys Asn Ile Arg Phe Thr 
        275                 280                 285             


Ser Pro Val Ser Leu Glu Ala Gln Gly Lys Lys Met Thr Val Ser Thr 
    290                 295                 300                 


Asp Asn Leu Leu Val Asn Lys Ala Ile Ser Lys Ser Gly Gln Leu Pro 
305                 310                 315                 320 


Thr Ser Ser Asn Leu Glu Ala Asn Ile Ser Cys Ser Leu Asn Glu Leu 
                325                 330                 335     


Thr Tyr Asn Asn Leu Pro Ala Asn Glu Asn Gln Asn Leu Lys Glu Gln 
            340                 345                 350         


Asn Gln Thr Glu Lys Ser Leu Lys Ser Pro Ser Asp Thr Leu Asp Gly 
        355                 360                 365             


Arg Asn Glu Asn Leu Gln Glu Ser Glu Ile Leu Ser Gln Pro Lys Ser 
    370                 375                 380                 


Leu Ser Leu Glu Ala Thr Ser Pro Leu Ser Ala Glu Lys His Ser Cys 
385                 390                 395                 400 


Thr Val Pro Glu Gly Leu Leu Phe Pro Ala Glu Tyr Tyr Val Arg Thr 
                405                 410                 415     


Thr Arg Ser Met Ser Asn Cys Gln Arg Lys Val Ala Val Glu Ala Val 
            420                 425                 430         


Ile Gln Ser His Leu Asp Val Lys Lys Lys Gly Phe Lys Asn Lys Asn 
        435                 440                 445             


Lys Asp Ala Ser Lys Asn Leu Asn Leu Ser Asn Glu Glu Thr Asp Gln 
    450                 455                 460                 


Ser Glu Ile Arg Met Ser Gly Thr Cys Thr Gly Gln Pro Ser Ser Arg 
465                 470                 475                 480 


Thr Ser Gln Lys Leu Leu Ser Leu Thr Lys Val Ser Ser Pro Ala Gly 
                485                 490                 495     


Pro Thr Glu Asp Asn Asp Leu Ser Arg Lys Ala Val Ala Gln Ala Pro 
            500                 505                 510         


Gly Arg Arg Tyr Thr Gly Lys Arg Lys Ser Ala Cys Thr Pro Ala Ser 
        515                 520                 525             


Asp His Cys Glu Pro Leu Leu Pro Thr Ser Ser Leu Ser Ile Val Asn 
    530                 535                 540                 


Arg Ser Lys Glu Glu Val Thr Ser His Lys Tyr Gln His Glu Lys Leu 
545                 550                 555                 560 


Phe Ile Gln Val Lys Gly Lys Lys Ser Arg His Gln Lys Glu Asp Ser 
                565                 570                 575     


Leu Ser Trp Ser Asn Ser Ala Tyr Leu Ser Leu Asp Asp Asp Ala Phe 
            580                 585                 590         


Thr Ala Pro Phe His Arg Asp Gly Met Leu Ser Leu Lys Gln Leu Leu 
        595                 600                 605             


Ser Phe Leu Ser Ile Thr Asp Phe Gln Leu Pro Asp Glu Asp Phe Gly 
    610                 615                 620                 


Pro Leu Lys Leu Glu Lys Val Lys Ser Cys Ser Glu Lys Pro Val Glu 
625                 630                 635                 640 


Pro Phe Glu Ser Lys Met Phe Gly Glu Arg His Leu Lys Glu Gly Ser 
                645                 650                 655     


Cys Ile Phe Pro Glu Glu Leu Ser Pro Lys Arg Met Asp Thr Glu Met 
            660                 665                 670         


Glu Asp Leu Glu Glu Asp Leu Ile Val Leu Pro Gly Lys Ser His Pro 
        675                 680                 685             


Lys Arg Pro Asn Ser Gln Ser Gln His Thr Lys Thr Gly Leu Ser Ser 
    690                 695                 700                 


Ser Ile Leu Leu Tyr Thr Pro Leu Asn Thr Val Ala Pro Asp Asp Asn 
705                 710                 715                 720 


Asp Arg Pro Thr Thr Asp Met Cys Ser Pro Ala Phe Pro Ile Leu Gly 
                725                 730                 735     


Thr Thr Pro Ala Phe Gly Pro Gln Gly Ser Tyr Glu Lys Ala Ser Thr 
            740                 745                 750         


Glu Val Ala Gly Arg Thr Cys Cys Thr Pro Gln Leu Ala His Leu Lys 
        755                 760                 765             


Asp Ser Val Cys Leu Ala Ser Asp Thr Lys Gln Phe Asp Ser Ser Gly 
    770                 775                 780                 


Ser Pro Ala Lys Pro His Thr Thr Leu Gln Val Ser Gly Arg Gln Gly 
785                 790                 795                 800 


Gln Pro Thr Cys Asp Cys Asp Ser Val Pro Pro Gly Thr Pro Pro Pro 
                805                 810                 815     


Ile Glu Ser Phe Thr Phe Lys Glu Asn Gln Leu Cys Arg Asn Thr Cys 
            820                 825                 830         


Gln Glu Leu His Lys His Ser Val Glu Gln Thr Glu Thr Ala Glu Leu 
        835                 840                 845             


Pro Ala Ser Asp Ser Ile Asn Pro Gly Asn Leu Gln Leu Val Ser Glu 
    850                 855                 860                 


Leu Lys Asn Pro Ser Gly Ser Cys Ser Val Asp Val Ser Ala Met Phe 
865                 870                 875                 880 


Trp Glu Arg Ala Gly Cys Lys Glu Pro Cys Ile Ile Thr Ala Cys Glu 
                885                 890                 895     


Asp Val Val Ser Leu Trp Lys Ala Leu Asp Ala Trp Gln Trp Glu Lys 
            900                 905                 910         


Leu Tyr Thr Trp His Phe Ala Glu Val Pro Val Leu Gln Ile Val Pro 
        915                 920                 925             


Val Pro Asp Val Tyr Asn Leu Val Cys Val Ala Leu Gly Asn Leu Glu 
    930                 935                 940                 


Ile Arg Glu Ile Arg Ala Leu Phe Cys Ser Ser Asp Asp Glu Ser Glu 
945                 950                 955                 960 


Lys Gln Val Leu Leu Lys Ser Gly Asn Ile Lys Ala Val Leu Gly Leu 
                965                 970                 975     


Thr Lys Arg Arg Leu Val Ser Ser Ser Gly Thr Leu Ser Asp Gln Gln 
            980                 985                 990         


Val Glu Val Met Thr Phe Ala Glu  Asp Gly Gly Gly Lys  Glu Asn Gln 
        995                 1000                 1005             


Phe Leu  Met Pro Pro Glu Glu  Thr Ile Leu Thr Phe  Ala Glu Val 
    1010                 1015                 1020             


Gln Gly  Met Gln Glu Ala Leu  Leu Gly Thr Thr Ile  Met Asn Asn 
    1025                 1030                 1035             


Ile Val  Ile Trp Asn Leu Lys  Thr Gly Gln Leu Leu  Lys Lys Met 
    1040                 1045                 1050             


His Ile  Asp Asp Ser Tyr Gln  Ala Ser Val Cys His  Lys Ala Tyr 
    1055                 1060                 1065             


Ser Glu  Met Gly Leu Leu Phe  Ile Val Leu Ser His  Pro Cys Ala 
    1070                 1075                 1080             


Lys Glu  Ser Glu Ser Leu Arg  Ser Pro Val Phe Gln  Leu Ile Val 
    1085                 1090                 1095             


Ile Asn  Pro Lys Thr Thr Leu  Ser Val Gly Val Met  Leu Tyr Cys 
    1100                 1105                 1110             


Leu Pro  Pro Gly Gln Ala Gly  Arg Phe Leu Glu Gly  Asp Val Lys 
    1115                 1120                 1125             


Asp His  Cys Ala Ala Ala Ile  Leu Thr Ser Gly Thr  Ile Ala Ile 
    1130                 1135                 1140             


Trp Asp  Leu Leu Leu Gly Gln  Cys Thr Ala Leu Leu  Pro Pro Val 
    1145                 1150                 1155             


Ser Asp  Gln His Trp Ser Phe  Val Lys Trp Ser Gly  Thr Asp Ser 
    1160                 1165                 1170             


His Leu  Leu Ala Gly Gln Lys  Asp Gly Asn Ile Phe  Val Tyr His 
    1175                 1180                 1185             


Tyr Ser  Asn Asp Gly Gly Gly  Gly Ser Asp Pro Lys  Lys Lys Arg 
    1190                 1195                 1200             


Lys Val  Asp Pro Lys Lys Lys  Arg Lys Val Asp Pro  Lys Lys Lys 
    1205                 1210                 1215             


Arg Lys  Val Gly Ser Thr Gly  Ser Arg Asn Asp Gly  Gly Gly Gly 
    1220                 1225                 1230             


Ser Gly  Gly Gly Gly Ser Gly  Gly Gly Gly Ser Gly  Arg Ala Gly 
    1235                 1240                 1245             


Ile Leu  Pro Pro Lys Lys Lys  Arg Lys Val Ser Arg  Gly Arg Ser 
    1250                 1255                 1260             


Arg Leu  Leu Glu Asp Phe Arg  Asn Asn Arg Tyr Pro  Asn Leu Gln 
    1265                 1270                 1275             


Leu Arg  Glu Ile Ala Gly His  Ile Met Glu Phe Ser  Gln Asp Gln 
    1280                 1285                 1290             


His Gly  Ser Arg Phe Ile Gln  Leu Lys Leu Glu Arg  Ala Thr Pro 
    1295                 1300                 1305             


Ala Glu  Arg Gln Leu Val Phe  Asn Glu Ile Leu Gln  Ala Ala Tyr 
    1310                 1315                 1320             


Gln Leu  Met Val Asp Val Phe  Gly Asn Tyr Val Ile  Gln Lys Phe 
    1325                 1330                 1335             


Phe Glu  Phe Gly Ser Leu Glu  Gln Lys Leu Ala Leu  Ala Glu Arg 
    1340                 1345                 1350             


Ile Arg  Gly His Val Leu Ser  Leu Ala Leu Gln Met  Tyr Gly Ser 
    1355                 1360                 1365             


Arg Val  Ile Glu Lys Ala Leu  Glu Phe Ile Pro Ser  Asp Gln Gln 
    1370                 1375                 1380             


Asn Glu  Met Val Arg Glu Leu  Asp Gly His Val Leu  Lys Cys Val 
    1385                 1390                 1395             


Lys Asp  Gln Asn Gly Asn His  Val Val Gln Lys Cys  Ile Glu Cys 
    1400                 1405                 1410             


Val Gln  Pro Gln Ser Leu Gln  Phe Ile Ile Asp Ala  Phe Lys Gly 
    1415                 1420                 1425             


Gln Val  Phe Ala Leu Ser Thr  His Pro Tyr Gly Cys  Arg Val Ile 
    1430                 1435                 1440             


Gln Arg  Ile Leu Glu His Cys  Leu Pro Asp Gln Thr  Leu Pro Ile 
    1445                 1450                 1455             


Leu Glu  Glu Leu His Gln His  Thr Glu Gln Leu Val  Gln Asp Gln 
    1460                 1465                 1470             


Tyr Gly  Asn Tyr Val Ile Gln  His Val Leu Glu His  Gly Arg Pro 
    1475                 1480                 1485             


Glu Asp  Lys Ser Lys Ile Val  Ala Glu Ile Arg Gly  Asn Val Leu 
    1490                 1495                 1500             


Val Leu  Ser Gln His Lys Phe  Ala Ser Asn Val Val  Glu Lys Cys 
    1505                 1510                 1515             


Val Thr  His Ala Ser Arg Thr  Glu Arg Ala Val Leu  Ile Asp Glu 
    1520                 1525                 1530             


Val Cys  Thr Met Asn Asp Gly  Pro His Ser Ala Leu  Tyr Thr Met 
    1535                 1540                 1545             


Met Lys  Asp Gln Tyr Ala Asn  Tyr Val Val Gln Lys  Met Ile Asp 
    1550                 1555                 1560             


Val Ala  Glu Pro Gly Gln Arg  Lys Ile Val Met His  Lys Ile Arg 
    1565                 1570                 1575             


Pro His  Ile Ala Thr Leu Arg  Lys Tyr Thr Tyr Gly  Lys His Ile 
    1580                 1585                 1590             


Leu Ala  Lys Leu Glu Lys Tyr  Tyr Met Lys Asn Gly  Val Asp Leu 
    1595                 1600                 1605             


Gly Asp  Pro Lys Lys Lys Arg  Lys Val Asp Pro Lys  Lys Lys Arg 
    1610                 1615                 1620             


Lys Val  Gly Gly Arg Gly Gly  Gly Gly Ser Gly Gly  Gly Gly Ser 
    1625                 1630                 1635             


Gly Gly  Gly Gly Ser Gly Pro  Ala 
    1640                 1645     


<210>  49
<211>  7064
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide

<400>  49
tcaatattgg ccattagcca tattattcat tggttatata gcataaatca atattggcta       60

ttggccattg catacgttgt atctatatca taatatgtac atttatattg gctcatgtcc      120

aatatgaccg ccatgttggc attgattatt gactagttat taatagtaat caattacggg      180

gtcattagtt catagcccat atatggagtt ccgcgttaca taacttacgg taaatggccc      240

gcctggctga ccgcccaacg acccccgccc attgacgtca ataatgacgt atgttcccat      300

agtaacgcca atagggactt tccattgacg tcaatgggtg gagtatttac ggtaaactgc      360

ccacttggca gtacatcaag tgtatcatat gccaagtccg ccccctattg acgtcaatga      420

cggtaaatgg cccgcctggc attatgccca gtacatgacc ttacgggact ttcctacttg      480

gcagtacatc tacgtattag tcatcgctat taccatggtg atgcggtttt ggcagtacac      540

caatgggcgt ggatagcggt ttgactcacg gggatttcca agtctccacc ccattgacgt      600

caatgggagt ttgttttggc accaaaatca acgggacttt ccaaaatgtc gtaataaccc      660

cgccccgttg acgcaaatgg gcggtaggcg tgtacggtgg gaggtctata taagcagagg      720

tcgtttagtg aaccgtcaga tcactagtag ctttattgcg gtagtttatc acagttaaat      780

tgctaacgca gtcagtgctc gactgatcac aggtaagtat caaggttaca agacaggttt      840

aaggaggcca atagaaactg ggcttgtcga gacagagaag attcttgcgt ttctgatagg      900

cacctattgg tcttactgac atccactttg cctttctctc cacagggaaa aaacaattga      960

caagtttgta caaaaaagca ggctccgaat tcaccggtgc cgccaccatg atcgatggcg     1020

gaggcggatc tgatccaaaa aagaagagaa aggtagatcc aaaaaagaag agaaaggtag     1080

atccaaaaaa gaagagaaag gtaggatcta ccggatctag aaacgatggt ggtggtggaa     1140

gcgggggtgg gggcagcggt ggagggggaa gcgggcgcgc cgggatcctc ccccccaaga     1200

aaaagaggaa ggtatctaga ggccgcagcc gccttttgga agattttcga aacaaccggt     1260

accccaattt acaactgcgg gagattgctg gacatataat ggaattttcc caagaccagc     1320

atgggtccag attcattcag ctgaaactgg agcgtgccac accagctgag cgccagcttg     1380

tcttcaatga aatcctccag gctgcctacc aactcatggt ggatgtgttt ggtaattacg     1440

tcattcagaa gttctttgaa tttggcagtc ttgaacagaa gctggctttg gcagaacgga     1500

ttcgaggcca cgtcctgtca ttggcactac agatgtatgg cagccgtgtt atcgagaaag     1560

ctcttgagtt tattccttca gaccagcaga atgagatggt tcgggaacta gatggccatg     1620

tcttgaagtg tgtgaaagat cagaatggca atcacgtggt tcagaaatgc attgaatgtg     1680

tacagcccca gtctttgcaa tttatcatcg acgcgtttaa gggacaggta tttgccttat     1740

ccacacatcc ttatggctgc cgagtgattc agagaatcct ggagcactgt ctccctgacc     1800

agacactccc tattttagag gagcttcacc agcacacaga gcagctggta caggatcaat     1860

atggaaatta tgtaatccaa catgtactgg agcacggtcg tcctgaggat aaaagcaaaa     1920

ttgtagcaga aatccgaggc aatgtacttg tattgagtca gcacaaattt gcaagcaatg     1980

ttgtggagaa gtgtgttact cacgcctcac gtacggagcg cgctgtgctc atcgacgagg     2040

tgtgcaccat gaacgacggt ccccacagtg ccttatacac catgatgaag gaccagtatg     2100

ccaactacgt ggtccagaag atgattgacg tggcggagcc aggccagcgg aagatcgtca     2160

tgcataagat ccggccccac atcgcaactc ttcgtaagta cacctatggc aagcacattc     2220

tggccaagct ggagaagtac tacatgaaga acggtgttga cttaggggac ccaaagaaga     2280

agcgcaaagt ggatcctaaa aagaaaagaa aggtaggcgg ccgcggggga ggcggttccg     2340

gtggcggcgg aagcggaggt ggaggatcag ggccggccat gaacatctcg ggaagcagct     2400

gtggaagccc taactctgca gatacatcta gtgactttaa ggacctttgg acaaaactaa     2460

aagaatgtca tgatagagaa gtacaaggtt tacaagtaaa agtaaccaag ctaaaacagg     2520

aacgaatctt agatgcacaa agactagaag aattcttcac caaaaatcaa cagctgaggg     2580

aacagcagaa agtccttcat gaaaccatta aagttttaga agatcggtta agagcaggct     2640

tatgtgatcg ctgtgcagta actgaagaac atatgcggaa aaaacagcaa gagtttgaaa     2700

atatccggca gcagaatctt aaacttatta cagaacttat gaatgaaagg aatactctac     2760

aggaagaaaa taaaaagctt tctgaacaac tccagcagaa aattgagaat gatcaacagc     2820

atcaagcagc tgagcttgaa tgtgaggaag acgttattcc agattcaccg ataacagcct     2880

tctcattttc tggcgttaac cggctacgaa gaaaggagaa cccccatgtc cgatacatag     2940

aacaaacaca tactaaattg gagcactctg tgtgtgcaaa tgaaatgaga aaagtttcca     3000

agtcttcaac tcatccacaa cataatccta atgaaaatga aattctagta gctgacactt     3060

atgaccaaag tcaatctcca atggccaaag cacatggaac aagcagctat acccctgata     3120

agtcatcttt taatttagct acagttgttg ctgaaacact tggacttggt gttcaagaag     3180

aatctgaaac tcaaggtccc atgagccccc ttggtgatga gctctaccac tgtctggaag     3240

gaaatcacaa gaaacagcct tttgaggaat ctacaagaaa tactgaagat agtttaagat     3300

tttcagattc tacttcaaag actcctcctc aagaagaatt acctactcga gtgtcatctc     3360

ctgtatttgg agctacctct agtatcaaaa gtggtttaga tttgaataca agtttgtccc     3420

cttctctttt acagcctggg aaaaaaaaac atctgaaaac actccctttt agcaacactt     3480

gtatatctag attagaaaaa actagatcaa aatctgaaga tagtgccctt ttcacacatc     3540

acagtcttgg gtctgaagtg aacaagatca ttatccagtc atctaataaa cagatactta     3600

taaataaaaa tataagtgaa tccctaggtg aacagaatag gactgagtac ggtaaagatt     3660

ctaacactga taaacatttg gagcccctga aatcattggg aggccgaaca tccaaaagga     3720

agaaaactga ggaagaaagt gaacatgaag taagctgccc ccaagcttct tttgataaag     3780

aaaatgcttt cccttttcca atggataatc agttttccat gaatggagac tgtgtgatgg     3840

ataaacctct ggatctgtct gatcgatttt cagctattca gcgtcaagag aaaagccaag     3900

gaagtgagac ttctaaaaac aaatttaggc aagtgactct ttatgaggct ttgaagacca     3960

ttccaaaggg cttttcctca agccgtaagg cctcagatgg caactgcacg ttgcccaaag     4020

attccccagg ggagccctgt tcacaggaat gcatcatcct tcagcccttg aataaatgct     4080

ctccagacaa taaaccatca ttacaaataa aagaagaaaa tgctgtcttt aaaattcctc     4140

tacgtccacg tgaaagtttg gagactgaga atgttttaga tgacataaag agtgctggtt     4200

ctcatgagcc aataaaaata caaaccaggt cagaccatgg aggatgtgaa cttgcatcag     4260

ttcttcagtt aaatccatgt agaactggta aaataaagtc tctacaaaac aaccaagatg     4320

tatcctttga aaatatccag tggagtatag atccgggagc agacctttct cagtataaaa     4380

tggatgttac tgtaatagat acaaaggatg gcagtcagtc aaaattagga ggagagacag     4440

tggacatgga ctgtacattg gttagtgaaa ccgttctctt aaaaatgaag aagcaagagc     4500

agaagggaga aaaaagttca aatgaagaaa gaaaaatgaa tgatagcttg gaagatatgt     4560

ttgatcggac aacacatgaa gagtatgaat cctgtttggc agacagtttc tcccaagcag     4620

cagatgaaga ggaggaattg tctactgcca caaagaaact acacactcat ggtgataaac     4680

aagacaaagt caagcagaaa gcgtttgtgg agccgtattt taaaggtgat gaaagagaga     4740

ctagcttgca aaattttcct catattgagg tggttcggaa aaaagaggag agaagaaaac     4800

tgcttgggca cacgtgtaag gaatgtgaaa tttattatgc agatatgcca gcagaagaaa     4860

gagaaaagaa attggcttcc tgctcaagac accgattccg ctacattcca cccaacgagc     4920

cagagaattt ttgggaagtt ggttttcctt ccactcagac ttgtatggaa agaggttata     4980

ttaaggaaga tcttgatcct tgtcctcgtc caaaaagacg tcagccttac aacgcaatat     5040

tttctccaaa aggcaaggag cagaagacaa acgtttgatt aattaagaat tcgacccagc     5100

tttcttgtac aaagtggttg atatccagca cagtggcggc cgctcgagtc tagagggccc     5160

gcggttcgaa ggtaagccta tccctaaccc tctcctcggt ctcgattcta cgcgtaccgg     5220

ttagcaattg ttttttcgat gagtttggac aaaccacaac tagaatgcag tgaaaaaaat     5280

gctttatttg tgaaatttgt gatgctattg ctttatttgt aaccattata agctgcaata     5340

aacaagttaa caacaacaat tgcattcatt ttatgtttca ggttcagggg gaggtgtggg     5400

aggtttttta aagcaagtaa aacctctaca aatgtggtac ttaagagggg gagaccaaag     5460

ggcgagacgt taaggcctca cgtgacatgt gagcaaaagg ccagcaaaag gccaggaacc     5520

gtaaaaaggc cgcgttgctg gcgtttttcc ataggctccg cccccctgac gagcatcaca     5580

aaaatcgacg ctcaagtcag aggtggcgaa acccgacagg actataaaga taccaggcgt     5640

ttccccctgg aagctccctc gtgcgctctc ctgttccgac cctgccgctt accggatacc     5700

tgtccgcctt tctcccttcg ggaagcgtgg cgctttctca tagctcacgc tgtaggtatc     5760

tcagttcggt gtaggtcgtt cgctccaagc tgggctgtgt gcacgaaccc cccgttcagc     5820

ccgaccgctg cgccttatcc ggtaactatc gtcttgagtc caacccggta agacacgact     5880

tatcgccact ggcagcagcc actggtaaca ggattagcag agcgaggtat gtaggcggtg     5940

ctacagagtt cttgaagtgg tggcctaact acggctacac tagaaggaca gtatttggta     6000

tctgcgctct gctgaagcca gttaccttcg gaaaaagagt tggtagctct tgatccggca     6060

aacaaaccac gctggtagcg gtggtttttt tgtttgcaag cagcagatta cgcgcagaaa     6120

aaaaggatct caagaagatc ctttgatctt ttctacgggg tctgacgctc agtggaacga     6180

aaactcacgt taagggattt tggtcatgcc gtctcagaag aactcgtcaa gaaggcgata     6240

gaaggcgatg cgctgcgaat cgggagcggc gataccgtaa agcacgagga agcggtcagc     6300

ccattcgccg ccaagctctt cagcaatatc acgggtagcc aacgctatgt cctgatagcg     6360

gtccgccaca cccagccggc cacagtcgat gaatccagaa aagcggccat tttccaccat     6420

gatattcggc aagcaggcat cgccatgggt cacgacgaga tcctcgccgt cgggcatgct     6480

cgccttgagc ctggcgaaca gttcggctgg cgcgagcccc tgatgctctt cgtccagatc     6540

atcctgatcg acaagaccgg cttccatccg agtacgtgct cgctcgatgc gatgtttcgc     6600

ttggtggtcg aatgggcagg tagccggatc aagcgtatgc agccgccgca ttgcatcagc     6660

catgatggat actttctcgg caggagcaag gtgagatgac aggagatcct gccccggcac     6720

ttcgcccaat agcagccagt cccttcccgc ttcagtgaca acgtcgagca cagctgcgca     6780

aggaacgccc gtcgtggcca gccacgatag ccgcgctgcc tcgtcttgca gttcattcag     6840

ggcaccggac aggtcggtct tgacaaaaag aaccgggcgc ccctgcgctg acagccggaa     6900

cacggcggca tcagagcagc cgattgtctg ttgtgcccag tcatagccga atagcctctc     6960

cacccaagcg gccggagaac ctgcgtgcaa tccatcttgt tcaatcataa tattattgaa     7020

gcatttatca gggttcgtct cgtcccggtc tcctcccatg catg                      7064


<210>  50
<211>  1356
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  50

Met Ile Asp Gly Gly Gly Gly Ser Asp Pro Lys Lys Lys Arg Lys Val 
1               5                   10                  15      


Asp Pro Lys Lys Lys Arg Lys Val Asp Pro Lys Lys Lys Arg Lys Val 
            20                  25                  30          


Gly Ser Thr Gly Ser Arg Asn Asp Gly Gly Gly Gly Ser Gly Gly Gly 
        35                  40                  45              


Gly Ser Gly Gly Gly Gly Ser Gly Arg Ala Gly Ile Leu Pro Pro Lys 
    50                  55                  60                  


Lys Lys Arg Lys Val Ser Arg Gly Arg Ser Arg Leu Leu Glu Asp Phe 
65                  70                  75                  80  


Arg Asn Asn Arg Tyr Pro Asn Leu Gln Leu Arg Glu Ile Ala Gly His 
                85                  90                  95      


Ile Met Glu Phe Ser Gln Asp Gln His Gly Ser Arg Phe Ile Gln Leu 
            100                 105                 110         


Lys Leu Glu Arg Ala Thr Pro Ala Glu Arg Gln Leu Val Phe Asn Glu 
        115                 120                 125             


Ile Leu Gln Ala Ala Tyr Gln Leu Met Val Asp Val Phe Gly Asn Tyr 
    130                 135                 140                 


Val Ile Gln Lys Phe Phe Glu Phe Gly Ser Leu Glu Gln Lys Leu Ala 
145                 150                 155                 160 


Leu Ala Glu Arg Ile Arg Gly His Val Leu Ser Leu Ala Leu Gln Met 
                165                 170                 175     


Tyr Gly Ser Arg Val Ile Glu Lys Ala Leu Glu Phe Ile Pro Ser Asp 
            180                 185                 190         


Gln Gln Asn Glu Met Val Arg Glu Leu Asp Gly His Val Leu Lys Cys 
        195                 200                 205             


Val Lys Asp Gln Asn Gly Asn His Val Val Gln Lys Cys Ile Glu Cys 
    210                 215                 220                 


Val Gln Pro Gln Ser Leu Gln Phe Ile Ile Asp Ala Phe Lys Gly Gln 
225                 230                 235                 240 


Val Phe Ala Leu Ser Thr His Pro Tyr Gly Cys Arg Val Ile Gln Arg 
                245                 250                 255     


Ile Leu Glu His Cys Leu Pro Asp Gln Thr Leu Pro Ile Leu Glu Glu 
            260                 265                 270         


Leu His Gln His Thr Glu Gln Leu Val Gln Asp Gln Tyr Gly Asn Tyr 
        275                 280                 285             


Val Ile Gln His Val Leu Glu His Gly Arg Pro Glu Asp Lys Ser Lys 
    290                 295                 300                 


Ile Val Ala Glu Ile Arg Gly Asn Val Leu Val Leu Ser Gln His Lys 
305                 310                 315                 320 


Phe Ala Ser Asn Val Val Glu Lys Cys Val Thr His Ala Ser Arg Thr 
                325                 330                 335     


Glu Arg Ala Val Leu Ile Asp Glu Val Cys Thr Met Asn Asp Gly Pro 
            340                 345                 350         


His Ser Ala Leu Tyr Thr Met Met Lys Asp Gln Tyr Ala Asn Tyr Val 
        355                 360                 365             


Val Gln Lys Met Ile Asp Val Ala Glu Pro Gly Gln Arg Lys Ile Val 
    370                 375                 380                 


Met His Lys Ile Arg Pro His Ile Ala Thr Leu Arg Lys Tyr Thr Tyr 
385                 390                 395                 400 


Gly Lys His Ile Leu Ala Lys Leu Glu Lys Tyr Tyr Met Lys Asn Gly 
                405                 410                 415     


Val Asp Leu Gly Asp Pro Lys Lys Lys Arg Lys Val Asp Pro Lys Lys 
            420                 425                 430         


Lys Arg Lys Val Gly Gly Arg Gly Gly Gly Gly Ser Gly Gly Gly Gly 
        435                 440                 445             


Ser Gly Gly Gly Gly Ser Gly Pro Ala Met Asn Ile Ser Gly Ser Ser 
    450                 455                 460                 


Cys Gly Ser Pro Asn Ser Ala Asp Thr Ser Ser Asp Phe Lys Asp Leu 
465                 470                 475                 480 


Trp Thr Lys Leu Lys Glu Cys His Asp Arg Glu Val Gln Gly Leu Gln 
                485                 490                 495     


Val Lys Val Thr Lys Leu Lys Gln Glu Arg Ile Leu Asp Ala Gln Arg 
            500                 505                 510         


Leu Glu Glu Phe Phe Thr Lys Asn Gln Gln Leu Arg Glu Gln Gln Lys 
        515                 520                 525             


Val Leu His Glu Thr Ile Lys Val Leu Glu Asp Arg Leu Arg Ala Gly 
    530                 535                 540                 


Leu Cys Asp Arg Cys Ala Val Thr Glu Glu His Met Arg Lys Lys Gln 
545                 550                 555                 560 


Gln Glu Phe Glu Asn Ile Arg Gln Gln Asn Leu Lys Leu Ile Thr Glu 
                565                 570                 575     


Leu Met Asn Glu Arg Asn Thr Leu Gln Glu Glu Asn Lys Lys Leu Ser 
            580                 585                 590         


Glu Gln Leu Gln Gln Lys Ile Glu Asn Asp Gln Gln His Gln Ala Ala 
        595                 600                 605             


Glu Leu Glu Cys Glu Glu Asp Val Ile Pro Asp Ser Pro Ile Thr Ala 
    610                 615                 620                 


Phe Ser Phe Ser Gly Val Asn Arg Leu Arg Arg Lys Glu Asn Pro His 
625                 630                 635                 640 


Val Arg Tyr Ile Glu Gln Thr His Thr Lys Leu Glu His Ser Val Cys 
                645                 650                 655     


Ala Asn Glu Met Arg Lys Val Ser Lys Ser Ser Thr His Pro Gln His 
            660                 665                 670         


Asn Pro Asn Glu Asn Glu Ile Leu Val Ala Asp Thr Tyr Asp Gln Ser 
        675                 680                 685             


Gln Ser Pro Met Ala Lys Ala His Gly Thr Ser Ser Tyr Thr Pro Asp 
    690                 695                 700                 


Lys Ser Ser Phe Asn Leu Ala Thr Val Val Ala Glu Thr Leu Gly Leu 
705                 710                 715                 720 


Gly Val Gln Glu Glu Ser Glu Thr Gln Gly Pro Met Ser Pro Leu Gly 
                725                 730                 735     


Asp Glu Leu Tyr His Cys Leu Glu Gly Asn His Lys Lys Gln Pro Phe 
            740                 745                 750         


Glu Glu Ser Thr Arg Asn Thr Glu Asp Ser Leu Arg Phe Ser Asp Ser 
        755                 760                 765             


Thr Ser Lys Thr Pro Pro Gln Glu Glu Leu Pro Thr Arg Val Ser Ser 
    770                 775                 780                 


Pro Val Phe Gly Ala Thr Ser Ser Ile Lys Ser Gly Leu Asp Leu Asn 
785                 790                 795                 800 


Thr Ser Leu Ser Pro Ser Leu Leu Gln Pro Gly Lys Lys Lys His Leu 
                805                 810                 815     


Lys Thr Leu Pro Phe Ser Asn Thr Cys Ile Ser Arg Leu Glu Lys Thr 
            820                 825                 830         


Arg Ser Lys Ser Glu Asp Ser Ala Leu Phe Thr His His Ser Leu Gly 
        835                 840                 845             


Ser Glu Val Asn Lys Ile Ile Ile Gln Ser Ser Asn Lys Gln Ile Leu 
    850                 855                 860                 


Ile Asn Lys Asn Ile Ser Glu Ser Leu Gly Glu Gln Asn Arg Thr Glu 
865                 870                 875                 880 


Tyr Gly Lys Asp Ser Asn Thr Asp Lys His Leu Glu Pro Leu Lys Ser 
                885                 890                 895     


Leu Gly Gly Arg Thr Ser Lys Arg Lys Lys Thr Glu Glu Glu Ser Glu 
            900                 905                 910         


His Glu Val Ser Cys Pro Gln Ala Ser Phe Asp Lys Glu Asn Ala Phe 
        915                 920                 925             


Pro Phe Pro Met Asp Asn Gln Phe Ser Met Asn Gly Asp Cys Val Met 
    930                 935                 940                 


Asp Lys Pro Leu Asp Leu Ser Asp Arg Phe Ser Ala Ile Gln Arg Gln 
945                 950                 955                 960 


Glu Lys Ser Gln Gly Ser Glu Thr Ser Lys Asn Lys Phe Arg Gln Val 
                965                 970                 975     


Thr Leu Tyr Glu Ala Leu Lys Thr Ile Pro Lys Gly Phe Ser Ser Ser 
            980                 985                 990         


Arg Lys Ala Ser Asp Gly Asn Cys  Thr Leu Pro Lys Asp  Ser Pro Gly 
        995                 1000                 1005             


Glu Pro  Cys Ser Gln Glu Cys  Ile Ile Leu Gln Pro  Leu Asn Lys 
    1010                 1015                 1020             


Cys Ser  Pro Asp Asn Lys Pro  Ser Leu Gln Ile Lys  Glu Glu Asn 
    1025                 1030                 1035             


Ala Val  Phe Lys Ile Pro Leu  Arg Pro Arg Glu Ser  Leu Glu Thr 
    1040                 1045                 1050             


Glu Asn  Val Leu Asp Asp Ile  Lys Ser Ala Gly Ser  His Glu Pro 
    1055                 1060                 1065             


Ile Lys  Ile Gln Thr Arg Ser  Asp His Gly Gly Cys  Glu Leu Ala 
    1070                 1075                 1080             


Ser Val  Leu Gln Leu Asn Pro  Cys Arg Thr Gly Lys  Ile Lys Ser 
    1085                 1090                 1095             


Leu Gln  Asn Asn Gln Asp Val  Ser Phe Glu Asn Ile  Gln Trp Ser 
    1100                 1105                 1110             


Ile Asp  Pro Gly Ala Asp Leu  Ser Gln Tyr Lys Met  Asp Val Thr 
    1115                 1120                 1125             


Val Ile  Asp Thr Lys Asp Gly  Ser Gln Ser Lys Leu  Gly Gly Glu 
    1130                 1135                 1140             


Thr Val  Asp Met Asp Cys Thr  Leu Val Ser Glu Thr  Val Leu Leu 
    1145                 1150                 1155             


Lys Met  Lys Lys Gln Glu Gln  Lys Gly Glu Lys Ser  Ser Asn Glu 
    1160                 1165                 1170             


Glu Arg  Lys Met Asn Asp Ser  Leu Glu Asp Met Phe  Asp Arg Thr 
    1175                 1180                 1185             


Thr His  Glu Glu Tyr Glu Ser  Cys Leu Ala Asp Ser  Phe Ser Gln 
    1190                 1195                 1200             


Ala Ala  Asp Glu Glu Glu Glu  Leu Ser Thr Ala Thr  Lys Lys Leu 
    1205                 1210                 1215             


His Thr  His Gly Asp Lys Gln  Asp Lys Val Lys Gln  Lys Ala Phe 
    1220                 1225                 1230             


Val Glu  Pro Tyr Phe Lys Gly  Asp Glu Arg Glu Thr  Ser Leu Gln 
    1235                 1240                 1245             


Asn Phe  Pro His Ile Glu Val  Val Arg Lys Lys Glu  Glu Arg Arg 
    1250                 1255                 1260             


Lys Leu  Leu Gly His Thr Cys  Lys Glu Cys Glu Ile  Tyr Tyr Ala 
    1265                 1270                 1275             


Asp Met  Pro Ala Glu Glu Arg  Glu Lys Lys Leu Ala  Ser Cys Ser 
    1280                 1285                 1290             


Arg His  Arg Phe Arg Tyr Ile  Pro Pro Asn Glu Pro  Glu Asn Phe 
    1295                 1300                 1305             


Trp Glu  Val Gly Phe Pro Ser  Thr Gln Thr Cys Met  Glu Arg Gly 
    1310                 1315                 1320             


Tyr Ile  Lys Glu Asp Leu Asp  Pro Cys Pro Arg Pro  Lys Arg Arg 
    1325                 1330                 1335             


Gln Pro  Tyr Asn Ala Ile Phe  Ser Pro Lys Gly Lys  Glu Gln Lys 
    1340                 1345                 1350             


Thr Asn  Val 
    1355     


<210>  51
<211>  7931
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide

<400>  51
tcaatattgg ccattagcca tattattcat tggttatata gcataaatca atattggcta       60

ttggccattg catacgttgt atctatatca taatatgtac atttatattg gctcatgtcc      120

aatatgaccg ccatgttggc attgattatt gactagttat taatagtaat caattacggg      180

gtcattagtt catagcccat atatggagtt ccgcgttaca taacttacgg taaatggccc      240

gcctggctga ccgcccaacg acccccgccc attgacgtca ataatgacgt atgttcccat      300

agtaacgcca atagggactt tccattgacg tcaatgggtg gagtatttac ggtaaactgc      360

ccacttggca gtacatcaag tgtatcatat gccaagtccg ccccctattg acgtcaatga      420

cggtaaatgg cccgcctggc attatgccca gtacatgacc ttacgggact ttcctacttg      480

gcagtacatc tacgtattag tcatcgctat taccatggtg atgcggtttt ggcagtacac      540

caatgggcgt ggatagcggt ttgactcacg gggatttcca agtctccacc ccattgacgt      600

caatgggagt ttgttttggc accaaaatca acgggacttt ccaaaatgtc gtaataaccc      660

cgccccgttg acgcaaatgg gcggtaggcg tgtacggtgg gaggtctata taagcagagg      720

tcgtttagtg aaccgtcaga tcactagtag ctttattgcg gtagtttatc acagttaaat      780

tgctaacgca gtcagtgctc gactgatcac aggtaagtat caaggttaca agacaggttt      840

aaggaggcca atagaaactg ggcttgtcga gacagagaag attcttgcgt ttctgatagg      900

cacctattgg tcttactgac atccactttg cctttctctc cacagggaaa aaacaattga      960

caagtttgta caaaaaagca ggctccgaat tcaccggtgc cgccaccatg atcgatggcg     1020

gaggcggatc tgatccaaaa aagaagagaa aggtagatcc aaaaaagaag agaaaggtag     1080

atccaaaaaa gaagagaaag gtaggatcta ccggatctag aaacgatggt ggtggtggaa     1140

gcgggggtgg gggcagcggt ggagggggaa gcgggcgcgc cgggatcctc ccccccaaga     1200

aaaagaggaa ggtatctaga ggccgcagcc gccttttgga agattttcga aacaaccggt     1260

accccaattt acaactgcgg gagattgctg gacatataat ggaattttcc caagaccagc     1320

atgggtccag attcattcag ctgaaactgg agcgtgccac accagctgag cgccagcttg     1380

tcttcaatga aatcctccag gctgcctacc aactcatggt ggatgtgttt ggtaattacg     1440

tcattcagaa gttctttgaa tttggcagtc ttgaacagaa gctggctttg gcagaacgga     1500

ttcgaggcca cgtcctgtca ttggcactac agatgtatgg cagccgtgtt atcgagaaag     1560

ctcttgagtt tattccttca gaccagcaga atgagatggt tcgggaacta gatggccatg     1620

tcttgaagtg tgtgaaagat cagaatggca atcacgtggt tcagaaatgc attgaatgtg     1680

tacagcccca gtctttgcaa tttatcatcg acgcgtttaa gggacaggta tttgccttat     1740

ccacacatcc ttatggctgc cgagtgattc agagaatcct ggagcactgt ctccctgacc     1800

agacactccc tattttagag gagcttcacc agcacacaga gcagctggta caggatcaat     1860

atggaaatta tgtaatccaa catgtactgg agcacggtcg tcctgaggat aaaagcaaaa     1920

ttgtagcaga aatccgaggc aatgtacttg tattgagtca gcacaaattt gcaagcaatg     1980

ttgtggagaa gtgtgttact cacgcctcac gtacggagcg cgctgtgctc atcgacgagg     2040

tgtgcaccat gaacgacggt ccccacagtg ccttatacac catgatgaag gaccagtatg     2100

ccaactacgt ggtccagaag atgattgacg tggcggagcc aggccagcgg aagatcgtca     2160

tgcataagat ccggccccac atcgcaactc ttcgtaagta cacctatggc aagcacattc     2220

tggccaagct ggagaagtac tacatgaaga acggtgttga cttaggggac ccaaagaaga     2280

agcgcaaagt ggatcctaaa aagaaaagaa aggtaggcgg ccgcggggga ggcggttccg     2340

gtggcggcgg aagcggaggt ggaggatcag ggccggccat ggacgagcct cccgggaagc     2400

ccctcagctg tgaggagaga gagagacttc gagagaggct cgctttcctt cggcgggagt     2460

attcacgaac acttgcccga ttgcaacggg cgcaaagggc cgaacgcatc agacattcta     2520

ttaagaaaac agtagaagaa caagattgtt tgtctcagca ggatctctca ccgcagctaa     2580

aacactcaga acctaaaaat aaaatatgtg tttatgacaa gttacacatc aaaacccatc     2640

ttgatgaaga aactggagaa aagacatcta tcacacttga tgttgggcct gagtccttta     2700

accctggaga tggcccagga ggattaccta tacaaagaac agatgacacc caagaacatt     2760

ttccccacag ggtcagtgac cctagtggtg agcaaaagca gaagctgcca agcagaagaa     2820

agaagcagca gaagaggaca tttatttcac aggagagaga ctgtgtcttt ggcactgatt     2880

cactcagatt gtctgggaaa agactaaagg aacaggaaga aatcagtagc aaaaatcctg     2940

ctagatcacc agtaactgaa ataagaactc accttttaag tcttaaatct gaacttccag     3000

attctccaga accagttaca gaaattaatg aagacagtgt attaattcca ccaactgccc     3060

aaccagaaaa aggtgttgat acattcctaa gaagacctaa tttcaccagg gcgactacag     3120

ttcctttaca gactctatca gatagcggta gtagtcagca ccttgaacac attcctccta     3180

aaggtagcag tgaacttact actcacgacc taaaaaacat tagatttact tcacctgtaa     3240

gtttggaggc acaaggcaaa aaaatgactg tctctacaga taacctcctt gtaaataaag     3300

ctataagtaa aagtggccaa ctgcccacaa gttctaattt agaggcaaat atttcatgtt     3360

ctctaaatga actcacctac aataacttac cagcaaatga aaaccaaaac ttaaaagaac     3420

aaaatcaaac agagaaatct ttaaaatctc ccagtgacac tcttgatggc aggaatgaaa     3480

atcttcagga aagtgagatt ctaagtcaac ctaagagtct tagcctggaa gcaacctctc     3540

ctctttctgc agaaaaacat tcttgcacag tgcctgaagg ccttctgttt cctgcagaat     3600

attatgttag aacaacacga agcatgtcca attgccagag gaaagtagcc gtggaggctg     3660

tcattcagag tcatttggat gtcaagaaaa aagggtttaa aaataaaaat aaggatgcaa     3720

gtaaaaattt aaacctttcc aatgaggaaa ctgaccaaag tgaaattagg atgtctggca     3780

catgcacagg acaaccaagt tcaagaacct ctcagaaact tctctcatta actaaagtca     3840

gctctcccgc tgggcccact gaagataatg acttgtctag gaaggcagtt gcccaagcac     3900

ctggtagaag atacacagga aaaagaaaat cagcctgcac cccagcatca gatcattgtg     3960

aaccactttt gccaacttct agcctgtcga ttgttaacag gtccaaggaa gaagtcacct     4020

cacacaaata tcagcacgaa aaattattta ttcaagtgaa agggaagaaa agtcgtcatc     4080

aaaaagagga ttccctttct tggagtaata gtgcttattt atccttggat gatgatgctt     4140

tcacggctcc atttcatagg gatggaatgc tgagtttaaa gcaactactg tcttttctca     4200

gtatcacaga ctttcagtta cctgatgaag actttggacc tcttaagctt gaaaaagtga     4260

agtcctgctc agaaaaacca gtggagccct ttgagtcaaa aatgtttgga gagagacatc     4320

ttaaagaggg aagctgtatt tttccagagg aactgagtcc taaacgcatg gatacagaaa     4380

tggaggactt agaagaggac cttattgttc taccaggaaa atcacatccc aaaaggccaa     4440

actcgcaaag ccagcataca aagacgggcc tttcttcatc catattactt tatactcctt     4500

taaatacggt tgcgcctgat gataatgaca ggcctaccac agacatgtgt tcacctgctt     4560

tccccatctt aggtactact ccagcctttg gccctcaagg ctcctatgaa aaagcatcta     4620

cagaagttgc tggacgaact tgctgcacac cccaacttgc tcatttgaaa gactcagtct     4680

gtcttgccag tgatactaaa caattcgaca gttcaggcag cccagcaaaa ccacatacca     4740

ccctgcaagt gtcaggcagg caaggacaac ctacctgtga ctgtgactct gtcccgccag     4800

gaacacctcc acccattgag tcattcactt ttaaagaaaa tcagctctgt agaaacacat     4860

gccaggagct gcataaacat tccgtcgaac agactgaaac agcagagctt cctgcttctg     4920

atagcataaa cccaggcaac ctacaattgg tttcagagtt aaagaatcct tcaggttcct     4980

gttccgtaga tgtgagtgcc atgttttggg aaagagccgg ttgtaaagag ccatgtatca     5040

taactgcttg cgaagatgta gtttctcttt ggaaagctct ggatgcttgg cagtgggaaa     5100

aactttatac ctggcacttc gcagaggttc cagtattaca gatagttcca gtgcctgatg     5160

tgtataatct cgtgtgtgta gctttgggaa atttggaaat cagagagatc agggcattgt     5220

tttgttcctc tgatgatgaa agtgaaaagc aagtactact gaagtctgga aatataaaag     5280

ctgtgcttgg cctgacaaag aggaggctag ttagtagcag tgggaccctt tctgatcaac     5340

aagtagaagt catgacgttt gcagaagatg gaggaggcaa agaaaaccaa tttttgatgc     5400

cccctgagga gactatacta acttttgctg aggtccaagg gatgcaagaa gctctgcttg     5460

gtactactat tatgaacaac attgttattt ggaatttaaa aactggtcaa ctcctgaaaa     5520

agatgcacat tgatgattct taccaagctt cagtctgtca caaagcctat tctgaaatgg     5580

ggcttctctt tattgtcctg agtcatccct gtgccaaaga gagtgagtcg ttgcgaagcc     5640

ctgtgtttca gctcattgtg attaacccta agacgactct cagcgtgggt gtgatgctgt     5700

actgtcttcc tccagggcag gctggcaggt tcctggaagg tgacgtgaaa gatcactgtg     5760

cagcagcaat cttgacttct ggaacaattg ccatttggga cttacttctc ggtcagtgta     5820

ctgccctcct cccacctgtc tctgaccaac attggtcttt tgtgaaatgg tcgggtacag     5880

actctcattt gctggctgga caaaaagatg gaaatatatt tgtataccac tattcaaacg     5940

tttgattaat taagaattcg acccagcttt cttgtacaaa gtggttgata tccagcacag     6000

tggcggccgc tcgagtctag agggcccgcg gttcgaaggt aagcctatcc ctaaccctct     6060

cctcggtctc gattctacgc gtaccggtta gcaattgttt tttcgatgag tttggacaaa     6120

ccacaactag aatgcagtga aaaaaatgct ttatttgtga aatttgtgat gctattgctt     6180

tatttgtaac cattataagc tgcaataaac aagttaacaa caacaattgc attcatttta     6240

tgtttcaggt tcagggggag gtgtgggagg ttttttaaag caagtaaaac ctctacaaat     6300

gtggtactta agagggggag accaaagggc gagacgttaa ggcctcacgt gacatgtgag     6360

caaaaggcca gcaaaaggcc aggaaccgta aaaaggccgc gttgctggcg tttttccata     6420

ggctccgccc ccctgacgag catcacaaaa atcgacgctc aagtcagagg tggcgaaacc     6480

cgacaggact ataaagatac caggcgtttc cccctggaag ctccctcgtg cgctctcctg     6540

ttccgaccct gccgcttacc ggatacctgt ccgcctttct cccttcggga agcgtggcgc     6600

tttctcatag ctcacgctgt aggtatctca gttcggtgta ggtcgttcgc tccaagctgg     6660

gctgtgtgca cgaacccccc gttcagcccg accgctgcgc cttatccggt aactatcgtc     6720

ttgagtccaa cccggtaaga cacgacttat cgccactggc agcagccact ggtaacagga     6780

ttagcagagc gaggtatgta ggcggtgcta cagagttctt gaagtggtgg cctaactacg     6840

gctacactag aaggacagta tttggtatct gcgctctgct gaagccagtt accttcggaa     6900

aaagagttgg tagctcttga tccggcaaac aaaccacgct ggtagcggtg gtttttttgt     6960

ttgcaagcag cagattacgc gcagaaaaaa aggatctcaa gaagatcctt tgatcttttc     7020

tacggggtct gacgctcagt ggaacgaaaa ctcacgttaa gggattttgg tcatgccgtc     7080

tcagaagaac tcgtcaagaa ggcgatagaa ggcgatgcgc tgcgaatcgg gagcggcgat     7140

accgtaaagc acgaggaagc ggtcagccca ttcgccgcca agctcttcag caatatcacg     7200

ggtagccaac gctatgtcct gatagcggtc cgccacaccc agccggccac agtcgatgaa     7260

tccagaaaag cggccatttt ccaccatgat attcggcaag caggcatcgc catgggtcac     7320

gacgagatcc tcgccgtcgg gcatgctcgc cttgagcctg gcgaacagtt cggctggcgc     7380

gagcccctga tgctcttcgt ccagatcatc ctgatcgaca agaccggctt ccatccgagt     7440

acgtgctcgc tcgatgcgat gtttcgcttg gtggtcgaat gggcaggtag ccggatcaag     7500

cgtatgcagc cgccgcattg catcagccat gatggatact ttctcggcag gagcaaggtg     7560

agatgacagg agatcctgcc ccggcacttc gcccaatagc agccagtccc ttcccgcttc     7620

agtgacaacg tcgagcacag ctgcgcaagg aacgcccgtc gtggccagcc acgatagccg     7680

cgctgcctcg tcttgcagtt cattcagggc accggacagg tcggtcttga caaaaagaac     7740

cgggcgcccc tgcgctgaca gccggaacac ggcggcatca gagcagccga ttgtctgttg     7800

tgcccagtca tagccgaata gcctctccac ccaagcggcc ggagaacctg cgtgcaatcc     7860

atcttgttca atcataatat tattgaagca tttatcaggg ttcgtctcgt cccggtctcc     7920

tcccatgcat g                                                          7931


<210>  52
<211>  1645
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  52

Met Ile Asp Gly Gly Gly Gly Ser Asp Pro Lys Lys Lys Arg Lys Val 
1               5                   10                  15      


Asp Pro Lys Lys Lys Arg Lys Val Asp Pro Lys Lys Lys Arg Lys Val 
            20                  25                  30          


Gly Ser Thr Gly Ser Arg Asn Asp Gly Gly Gly Gly Ser Gly Gly Gly 
        35                  40                  45              


Gly Ser Gly Gly Gly Gly Ser Gly Arg Ala Gly Ile Leu Pro Pro Lys 
    50                  55                  60                  


Lys Lys Arg Lys Val Ser Arg Gly Arg Ser Arg Leu Leu Glu Asp Phe 
65                  70                  75                  80  


Arg Asn Asn Arg Tyr Pro Asn Leu Gln Leu Arg Glu Ile Ala Gly His 
                85                  90                  95      


Ile Met Glu Phe Ser Gln Asp Gln His Gly Ser Arg Phe Ile Gln Leu 
            100                 105                 110         


Lys Leu Glu Arg Ala Thr Pro Ala Glu Arg Gln Leu Val Phe Asn Glu 
        115                 120                 125             


Ile Leu Gln Ala Ala Tyr Gln Leu Met Val Asp Val Phe Gly Asn Tyr 
    130                 135                 140                 


Val Ile Gln Lys Phe Phe Glu Phe Gly Ser Leu Glu Gln Lys Leu Ala 
145                 150                 155                 160 


Leu Ala Glu Arg Ile Arg Gly His Val Leu Ser Leu Ala Leu Gln Met 
                165                 170                 175     


Tyr Gly Ser Arg Val Ile Glu Lys Ala Leu Glu Phe Ile Pro Ser Asp 
            180                 185                 190         


Gln Gln Asn Glu Met Val Arg Glu Leu Asp Gly His Val Leu Lys Cys 
        195                 200                 205             


Val Lys Asp Gln Asn Gly Asn His Val Val Gln Lys Cys Ile Glu Cys 
    210                 215                 220                 


Val Gln Pro Gln Ser Leu Gln Phe Ile Ile Asp Ala Phe Lys Gly Gln 
225                 230                 235                 240 


Val Phe Ala Leu Ser Thr His Pro Tyr Gly Cys Arg Val Ile Gln Arg 
                245                 250                 255     


Ile Leu Glu His Cys Leu Pro Asp Gln Thr Leu Pro Ile Leu Glu Glu 
            260                 265                 270         


Leu His Gln His Thr Glu Gln Leu Val Gln Asp Gln Tyr Gly Asn Tyr 
        275                 280                 285             


Val Ile Gln His Val Leu Glu His Gly Arg Pro Glu Asp Lys Ser Lys 
    290                 295                 300                 


Ile Val Ala Glu Ile Arg Gly Asn Val Leu Val Leu Ser Gln His Lys 
305                 310                 315                 320 


Phe Ala Ser Asn Val Val Glu Lys Cys Val Thr His Ala Ser Arg Thr 
                325                 330                 335     


Glu Arg Ala Val Leu Ile Asp Glu Val Cys Thr Met Asn Asp Gly Pro 
            340                 345                 350         


His Ser Ala Leu Tyr Thr Met Met Lys Asp Gln Tyr Ala Asn Tyr Val 
        355                 360                 365             


Val Gln Lys Met Ile Asp Val Ala Glu Pro Gly Gln Arg Lys Ile Val 
    370                 375                 380                 


Met His Lys Ile Arg Pro His Ile Ala Thr Leu Arg Lys Tyr Thr Tyr 
385                 390                 395                 400 


Gly Lys His Ile Leu Ala Lys Leu Glu Lys Tyr Tyr Met Lys Asn Gly 
                405                 410                 415     


Val Asp Leu Gly Asp Pro Lys Lys Lys Arg Lys Val Asp Pro Lys Lys 
            420                 425                 430         


Lys Arg Lys Val Gly Gly Arg Gly Gly Gly Gly Ser Gly Gly Gly Gly 
        435                 440                 445             


Ser Gly Gly Gly Gly Ser Gly Pro Ala Met Asp Glu Pro Pro Gly Lys 
    450                 455                 460                 


Pro Leu Ser Cys Glu Glu Arg Glu Arg Leu Arg Glu Arg Leu Ala Phe 
465                 470                 475                 480 


Leu Arg Arg Glu Tyr Ser Arg Thr Leu Ala Arg Leu Gln Arg Ala Gln 
                485                 490                 495     


Arg Ala Glu Arg Ile Arg His Ser Ile Lys Lys Thr Val Glu Glu Gln 
            500                 505                 510         


Asp Cys Leu Ser Gln Gln Asp Leu Ser Pro Gln Leu Lys His Ser Glu 
        515                 520                 525             


Pro Lys Asn Lys Ile Cys Val Tyr Asp Lys Leu His Ile Lys Thr His 
    530                 535                 540                 


Leu Asp Glu Glu Thr Gly Glu Lys Thr Ser Ile Thr Leu Asp Val Gly 
545                 550                 555                 560 


Pro Glu Ser Phe Asn Pro Gly Asp Gly Pro Gly Gly Leu Pro Ile Gln 
                565                 570                 575     


Arg Thr Asp Asp Thr Gln Glu His Phe Pro His Arg Val Ser Asp Pro 
            580                 585                 590         


Ser Gly Glu Gln Lys Gln Lys Leu Pro Ser Arg Arg Lys Lys Gln Gln 
        595                 600                 605             


Lys Arg Thr Phe Ile Ser Gln Glu Arg Asp Cys Val Phe Gly Thr Asp 
    610                 615                 620                 


Ser Leu Arg Leu Ser Gly Lys Arg Leu Lys Glu Gln Glu Glu Ile Ser 
625                 630                 635                 640 


Ser Lys Asn Pro Ala Arg Ser Pro Val Thr Glu Ile Arg Thr His Leu 
                645                 650                 655     


Leu Ser Leu Lys Ser Glu Leu Pro Asp Ser Pro Glu Pro Val Thr Glu 
            660                 665                 670         


Ile Asn Glu Asp Ser Val Leu Ile Pro Pro Thr Ala Gln Pro Glu Lys 
        675                 680                 685             


Gly Val Asp Thr Phe Leu Arg Arg Pro Asn Phe Thr Arg Ala Thr Thr 
    690                 695                 700                 


Val Pro Leu Gln Thr Leu Ser Asp Ser Gly Ser Ser Gln His Leu Glu 
705                 710                 715                 720 


His Ile Pro Pro Lys Gly Ser Ser Glu Leu Thr Thr His Asp Leu Lys 
                725                 730                 735     


Asn Ile Arg Phe Thr Ser Pro Val Ser Leu Glu Ala Gln Gly Lys Lys 
            740                 745                 750         


Met Thr Val Ser Thr Asp Asn Leu Leu Val Asn Lys Ala Ile Ser Lys 
        755                 760                 765             


Ser Gly Gln Leu Pro Thr Ser Ser Asn Leu Glu Ala Asn Ile Ser Cys 
    770                 775                 780                 


Ser Leu Asn Glu Leu Thr Tyr Asn Asn Leu Pro Ala Asn Glu Asn Gln 
785                 790                 795                 800 


Asn Leu Lys Glu Gln Asn Gln Thr Glu Lys Ser Leu Lys Ser Pro Ser 
                805                 810                 815     


Asp Thr Leu Asp Gly Arg Asn Glu Asn Leu Gln Glu Ser Glu Ile Leu 
            820                 825                 830         


Ser Gln Pro Lys Ser Leu Ser Leu Glu Ala Thr Ser Pro Leu Ser Ala 
        835                 840                 845             


Glu Lys His Ser Cys Thr Val Pro Glu Gly Leu Leu Phe Pro Ala Glu 
    850                 855                 860                 


Tyr Tyr Val Arg Thr Thr Arg Ser Met Ser Asn Cys Gln Arg Lys Val 
865                 870                 875                 880 


Ala Val Glu Ala Val Ile Gln Ser His Leu Asp Val Lys Lys Lys Gly 
                885                 890                 895     


Phe Lys Asn Lys Asn Lys Asp Ala Ser Lys Asn Leu Asn Leu Ser Asn 
            900                 905                 910         


Glu Glu Thr Asp Gln Ser Glu Ile Arg Met Ser Gly Thr Cys Thr Gly 
        915                 920                 925             


Gln Pro Ser Ser Arg Thr Ser Gln Lys Leu Leu Ser Leu Thr Lys Val 
    930                 935                 940                 


Ser Ser Pro Ala Gly Pro Thr Glu Asp Asn Asp Leu Ser Arg Lys Ala 
945                 950                 955                 960 


Val Ala Gln Ala Pro Gly Arg Arg Tyr Thr Gly Lys Arg Lys Ser Ala 
                965                 970                 975     


Cys Thr Pro Ala Ser Asp His Cys Glu Pro Leu Leu Pro Thr Ser Ser 
            980                 985                 990         


Leu Ser Ile Val Asn Arg Ser Lys  Glu Glu Val Thr Ser  His Lys Tyr 
        995                 1000                 1005             


Gln His  Glu Lys Leu Phe Ile  Gln Val Lys Gly Lys  Lys Ser Arg 
    1010                 1015                 1020             


His Gln  Lys Glu Asp Ser Leu  Ser Trp Ser Asn Ser  Ala Tyr Leu 
    1025                 1030                 1035             


Ser Leu  Asp Asp Asp Ala Phe  Thr Ala Pro Phe His  Arg Asp Gly 
    1040                 1045                 1050             


Met Leu  Ser Leu Lys Gln Leu  Leu Ser Phe Leu Ser  Ile Thr Asp 
    1055                 1060                 1065             


Phe Gln  Leu Pro Asp Glu Asp  Phe Gly Pro Leu Lys  Leu Glu Lys 
    1070                 1075                 1080             


Val Lys  Ser Cys Ser Glu Lys  Pro Val Glu Pro Phe  Glu Ser Lys 
    1085                 1090                 1095             


Met Phe  Gly Glu Arg His Leu  Lys Glu Gly Ser Cys  Ile Phe Pro 
    1100                 1105                 1110             


Glu Glu  Leu Ser Pro Lys Arg  Met Asp Thr Glu Met  Glu Asp Leu 
    1115                 1120                 1125             


Glu Glu  Asp Leu Ile Val Leu  Pro Gly Lys Ser His  Pro Lys Arg 
    1130                 1135                 1140             


Pro Asn  Ser Gln Ser Gln His  Thr Lys Thr Gly Leu  Ser Ser Ser 
    1145                 1150                 1155             


Ile Leu  Leu Tyr Thr Pro Leu  Asn Thr Val Ala Pro  Asp Asp Asn 
    1160                 1165                 1170             


Asp Arg  Pro Thr Thr Asp Met  Cys Ser Pro Ala Phe  Pro Ile Leu 
    1175                 1180                 1185             


Gly Thr  Thr Pro Ala Phe Gly  Pro Gln Gly Ser Tyr  Glu Lys Ala 
    1190                 1195                 1200             


Ser Thr  Glu Val Ala Gly Arg  Thr Cys Cys Thr Pro  Gln Leu Ala 
    1205                 1210                 1215             


His Leu  Lys Asp Ser Val Cys  Leu Ala Ser Asp Thr  Lys Gln Phe 
    1220                 1225                 1230             


Asp Ser  Ser Gly Ser Pro Ala  Lys Pro His Thr Thr  Leu Gln Val 
    1235                 1240                 1245             


Ser Gly  Arg Gln Gly Gln Pro  Thr Cys Asp Cys Asp  Ser Val Pro 
    1250                 1255                 1260             


Pro Gly  Thr Pro Pro Pro Ile  Glu Ser Phe Thr Phe  Lys Glu Asn 
    1265                 1270                 1275             


Gln Leu  Cys Arg Asn Thr Cys  Gln Glu Leu His Lys  His Ser Val 
    1280                 1285                 1290             


Glu Gln  Thr Glu Thr Ala Glu  Leu Pro Ala Ser Asp  Ser Ile Asn 
    1295                 1300                 1305             


Pro Gly  Asn Leu Gln Leu Val  Ser Glu Leu Lys Asn  Pro Ser Gly 
    1310                 1315                 1320             


Ser Cys  Ser Val Asp Val Ser  Ala Met Phe Trp Glu  Arg Ala Gly 
    1325                 1330                 1335             


Cys Lys  Glu Pro Cys Ile Ile  Thr Ala Cys Glu Asp  Val Val Ser 
    1340                 1345                 1350             


Leu Trp  Lys Ala Leu Asp Ala  Trp Gln Trp Glu Lys  Leu Tyr Thr 
    1355                 1360                 1365             


Trp His  Phe Ala Glu Val Pro  Val Leu Gln Ile Val  Pro Val Pro 
    1370                 1375                 1380             


Asp Val  Tyr Asn Leu Val Cys  Val Ala Leu Gly Asn  Leu Glu Ile 
    1385                 1390                 1395             


Arg Glu  Ile Arg Ala Leu Phe  Cys Ser Ser Asp Asp  Glu Ser Glu 
    1400                 1405                 1410             


Lys Gln  Val Leu Leu Lys Ser  Gly Asn Ile Lys Ala  Val Leu Gly 
    1415                 1420                 1425             


Leu Thr  Lys Arg Arg Leu Val  Ser Ser Ser Gly Thr  Leu Ser Asp 
    1430                 1435                 1440             


Gln Gln  Val Glu Val Met Thr  Phe Ala Glu Asp Gly  Gly Gly Lys 
    1445                 1450                 1455             


Glu Asn  Gln Phe Leu Met Pro  Pro Glu Glu Thr Ile  Leu Thr Phe 
    1460                 1465                 1470             


Ala Glu  Val Gln Gly Met Gln  Glu Ala Leu Leu Gly  Thr Thr Ile 
    1475                 1480                 1485             


Met Asn  Asn Ile Val Ile Trp  Asn Leu Lys Thr Gly  Gln Leu Leu 
    1490                 1495                 1500             


Lys Lys  Met His Ile Asp Asp  Ser Tyr Gln Ala Ser  Val Cys His 
    1505                 1510                 1515             


Lys Ala  Tyr Ser Glu Met Gly  Leu Leu Phe Ile Val  Leu Ser His 
    1520                 1525                 1530             


Pro Cys  Ala Lys Glu Ser Glu  Ser Leu Arg Ser Pro  Val Phe Gln 
    1535                 1540                 1545             


Leu Ile  Val Ile Asn Pro Lys  Thr Thr Leu Ser Val  Gly Val Met 
    1550                 1555                 1560             


Leu Tyr  Cys Leu Pro Pro Gly  Gln Ala Gly Arg Phe  Leu Glu Gly 
    1565                 1570                 1575             


Asp Val  Lys Asp His Cys Ala  Ala Ala Ile Leu Thr  Ser Gly Thr 
    1580                 1585                 1590             


Ile Ala  Ile Trp Asp Leu Leu  Leu Gly Gln Cys Thr  Ala Leu Leu 
    1595                 1600                 1605             


Pro Pro  Val Ser Asp Gln His  Trp Ser Phe Val Lys  Trp Ser Gly 
    1610                 1615                 1620             


Thr Asp  Ser His Leu Leu Ala  Gly Gln Lys Asp Gly  Asn Ile Phe 
    1625                 1630                 1635             


Val Tyr  His Tyr Ser Asn Val  
    1640                 1645 


<210>  53
<211>  5393
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide

<400>  53
tcaatattgg ccattagcca tattattcat tggttatata gcataaatca atattggcta       60

ttggccattg catacgttgt atctatatca taatatgtac atttatattg gctcatgtcc      120

aatatgaccg ccatgttggc attgattatt gactagttat taatagtaat caattacggg      180

gtcattagtt catagcccat atatggagtt ccgcgttaca taacttacgg taaatggccc      240

gcctggctga ccgcccaacg acccccgccc attgacgtca ataatgacgt atgttcccat      300

agtaacgcca atagggactt tccattgacg tcaatgggtg gagtatttac ggtaaactgc      360

ccacttggca gtacatcaag tgtatcatat gccaagtccg ccccctattg acgtcaatga      420

cggtaaatgg cccgcctggc attatgccca gtacatgacc ttacgggact ttcctacttg      480

gcagtacatc tacgtattag tcatcgctat taccatggtg atgcggtttt ggcagtacac      540

caatgggcgt ggatagcggt ttgactcacg gggatttcca agtctccacc ccattgacgt      600

caatgggagt ttgttttggc accaaaatca acgggacttt ccaaaatgtc gtaataaccc      660

cgccccgttg acgcaaatgg gcggtaggcg tgtacggtgg gaggtctata taagcagagg      720

tcgtttagtg aaccgtcaga tcactagtag ctttattgcg gtagtttatc acagttaaat      780

tgctaacgca gtcagtgctc gactgatcac aggtaagtat caaggttaca agacaggttt      840

aaggaggcca atagaaactg ggcttgtcga gacagagaag attcttgcgt ttctgatagg      900

cacctattgg tcttactgac atccactttg cctttctctc cacagggaaa aaacaattga      960

caagtttgta caaaaaagca ggctccgaat tcaccggtgc cgccaccatg gggccggcca     1020

tggcaatgca gatgcagctt gaagcaaatg cagatacttc agtggaagaa gaaagctttg     1080

gcccacaacc catttcacgg ttagagcagt gtggcataaa tgccaacgat gtgaagaaat     1140

tggaagaagc tggattccat actgtggagg ctgttgccta tgcgccaaag aaggagctaa     1200

taaatattaa gggaattagt gaagccaaag ctgataaaat tctggctgag gcagctaaat     1260

tagttccaat gggtttcacc actgcaactg aattccacca aaggcggtca gagatcatac     1320

agattactac tggctccaaa gagcttgaca aactacttca aggtggaatt gagactggat     1380

ctatcacaga aatgtttgga gaattccgaa ctgggaagac ccagatctgt catacgctag     1440

ctgtcacctg ccagcttccc attgaccggg gtggaggtga aggaaaggcc atgtacattg     1500

acactgaggg tacctttagg ccagaacggc tgctggcagt ggctgagagg tatggtctct     1560

ctggcagtga tgtcctggat aatgtagcat atgctcgagc gttcaacaca gaccaccaga     1620

cccagctcct ttatcaagca tcagccatga tggtagaatc taggtatgca ctgcttattg     1680

tagacagtgc caccgccctt tacagaacag actactcggg tcgaggtgag ctttcagcca     1740

ggcagatgca cttggccagg tttctgcgga tgcttctgcg actcgctgat gagtttggtg     1800

tagcagtggt aatcactaat caggtggtag ctcaagtgga tggagcagcg atgtttgctg     1860

ctgatcccaa aaaacctatt ggaggaaata tcatcgccca tgcatcaaca accagattgt     1920

atctgaggaa aggaagaggg gaaaccagaa tctgcaaaat ctacgactct ccctgtcttc     1980

ctgaagctga agctatgttc gccattaatg cagatggagt gggagatgcc aaagacatcg     2040

atggcggagg cggatctgat ccaaaaaaga agagaaaggt agatccaaaa aagaagagaa     2100

aggtagatcc aaaaaagaag agaaaggtag gatctaccgg atctagaaac gatggtggtg     2160

gtggaagcgg gggtgggggc agcggtggag ggggaagcgg gcgcgccggg atcctccccc     2220

ccaagaaaaa gaggaaggta tctagaggcc gcagccgcct tttggaagat tttcgaaaca     2280

accggtaccc caatttacaa ctgcgggaga ttgctggaca tataatggaa ttttcccaag     2340

accagcatgg gtccagattc attcagctga aactggagcg tgccacacca gctgagcgcc     2400

agcttgtctt caatgaaatc ctccaggctg cctaccaact catggtggat gtgtttggta     2460

attacgtcat tcagaagttc tttgaatttg gcagtcttga acagaagctg gctttggcag     2520

aacggattcg aggccacgtc ctgtcattgg cactacagat gtatggcagc cgtgttatcg     2580

agaaagctct tgagtttatt ccttcagacc agcagaatga gatggttcgg gaactagatg     2640

gccatgtctt gaagtgtgtg aaagatcaga atggcaatca cgtggttcag aaatgcattg     2700

aatgtgtaca gccccagtct ttgcaattta tcatcgacgc gtttaaggga caggtatttg     2760

ccttatccac acatccttat ggctgccgag tgattcagag aatcctggag cactgtctcc     2820

ctgaccagac actccctatt ttagaggagc ttcaccagca cacagagcag ctggtacagg     2880

atcaatatgg aaattatgta atccaacatg tactggagca cggtcgtcct gaggataaaa     2940

gcaaaattgt agcagaaatc cgaggcaatg tacttgtatt gagtcagcac aaatttgcaa     3000

gcaatgttgt ggagaagtgt gttactcacg cctcacgtac ggagcgcgct gtgctcatcg     3060

acgaggtgtg caccatgaac gacggtcccc acagtgcctt atacaccatg atgaaggacc     3120

agtatgccaa ctacgtggtc cagaagatga ttgacgtggc ggagccaggc cagcggaaga     3180

tcgtcatgca taagatccgg ccccacatcg caactcttcg taagtacacc tatggcaagc     3240

acattctggc caagctggag aagtactaca tgaagaacgg tgttgactta ggggacccaa     3300

agaagaagcg caaagtggat cctaaaaaga aaagaaaggt aggcggccgc gggggaggcg     3360

gttccggtgg cggcggaagc ggaggtggag gatcagggcc ggcctgatta attaagaatt     3420

cgacccagct ttcttgtaca aagtggttga tatccagcac agtggcggcc gctcgagtct     3480

agagggcccg cggttcgaag gtaagcctat ccctaaccct ctcctcggtc tcgattctac     3540

gcgtaccggt tagcaattgt tttttcgatg agtttggaca aaccacaact agaatgcagt     3600

gaaaaaaatg ctttatttgt gaaatttgtg atgctattgc tttatttgta accattataa     3660

gctgcaataa acaagttaac aacaacaatt gcattcattt tatgtttcag gttcaggggg     3720

aggtgtggga ggttttttaa agcaagtaaa acctctacaa atgtggtact taagaggggg     3780

agaccaaagg gcgagacgtt aaggcctcac gtgacatgtg agcaaaaggc cagcaaaagg     3840

ccaggaaccg taaaaaggcc gcgttgctgg cgtttttcca taggctccgc ccccctgacg     3900

agcatcacaa aaatcgacgc tcaagtcaga ggtggcgaaa cccgacagga ctataaagat     3960

accaggcgtt tccccctgga agctccctcg tgcgctctcc tgttccgacc ctgccgctta     4020

ccggatacct gtccgccttt ctcccttcgg gaagcgtggc gctttctcat agctcacgct     4080

gtaggtatct cagttcggtg taggtcgttc gctccaagct gggctgtgtg cacgaacccc     4140

ccgttcagcc cgaccgctgc gccttatccg gtaactatcg tcttgagtcc aacccggtaa     4200

gacacgactt atcgccactg gcagcagcca ctggtaacag gattagcaga gcgaggtatg     4260

taggcggtgc tacagagttc ttgaagtggt ggcctaacta cggctacact agaaggacag     4320

tatttggtat ctgcgctctg ctgaagccag ttaccttcgg aaaaagagtt ggtagctctt     4380

gatccggcaa acaaaccacg ctggtagcgg tggttttttt gtttgcaagc agcagattac     4440

gcgcagaaaa aaaggatctc aagaagatcc tttgatcttt tctacggggt ctgacgctca     4500

gtggaacgaa aactcacgtt aagggatttt ggtcatgccg tctcagaaga actcgtcaag     4560

aaggcgatag aaggcgatgc gctgcgaatc gggagcggcg ataccgtaaa gcacgaggaa     4620

gcggtcagcc cattcgccgc caagctcttc agcaatatca cgggtagcca acgctatgtc     4680

ctgatagcgg tccgccacac ccagccggcc acagtcgatg aatccagaaa agcggccatt     4740

ttccaccatg atattcggca agcaggcatc gccatgggtc acgacgagat cctcgccgtc     4800

gggcatgctc gccttgagcc tggcgaacag ttcggctggc gcgagcccct gatgctcttc     4860

gtccagatca tcctgatcga caagaccggc ttccatccga gtacgtgctc gctcgatgcg     4920

atgtttcgct tggtggtcga atgggcaggt agccggatca agcgtatgca gccgccgcat     4980

tgcatcagcc atgatggata ctttctcggc aggagcaagg tgagatgaca ggagatcctg     5040

ccccggcact tcgcccaata gcagccagtc ccttcccgct tcagtgacaa cgtcgagcac     5100

agctgcgcaa ggaacgcccg tcgtggccag ccacgatagc cgcgctgcct cgtcttgcag     5160

ttcattcagg gcaccggaca ggtcggtctt gacaaaaaga accgggcgcc cctgcgctga     5220

cagccggaac acggcggcat cagagcagcc gattgtctgt tgtgcccagt catagccgaa     5280

tagcctctcc acccaagcgg ccggagaacc tgcgtgcaat ccatcttgtt caatcataat     5340

attattgaag catttatcag ggttcgtctc gtcccggtct cctcccatgc atg            5393


<210>  54
<211>  799
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  54

Met Gly Pro Ala Met Ala Met Gln Met Gln Leu Glu Ala Asn Ala Asp 
1               5                   10                  15      


Thr Ser Val Glu Glu Glu Ser Phe Gly Pro Gln Pro Ile Ser Arg Leu 
            20                  25                  30          


Glu Gln Cys Gly Ile Asn Ala Asn Asp Val Lys Lys Leu Glu Glu Ala 
        35                  40                  45              


Gly Phe His Thr Val Glu Ala Val Ala Tyr Ala Pro Lys Lys Glu Leu 
    50                  55                  60                  


Ile Asn Ile Lys Gly Ile Ser Glu Ala Lys Ala Asp Lys Ile Leu Ala 
65                  70                  75                  80  


Glu Ala Ala Lys Leu Val Pro Met Gly Phe Thr Thr Ala Thr Glu Phe 
                85                  90                  95      


His Gln Arg Arg Ser Glu Ile Ile Gln Ile Thr Thr Gly Ser Lys Glu 
            100                 105                 110         


Leu Asp Lys Leu Leu Gln Gly Gly Ile Glu Thr Gly Ser Ile Thr Glu 
        115                 120                 125             


Met Phe Gly Glu Phe Arg Thr Gly Lys Thr Gln Ile Cys His Thr Leu 
    130                 135                 140                 


Ala Val Thr Cys Gln Leu Pro Ile Asp Arg Gly Gly Gly Glu Gly Lys 
145                 150                 155                 160 


Ala Met Tyr Ile Asp Thr Glu Gly Thr Phe Arg Pro Glu Arg Leu Leu 
                165                 170                 175     


Ala Val Ala Glu Arg Tyr Gly Leu Ser Gly Ser Asp Val Leu Asp Asn 
            180                 185                 190         


Val Ala Tyr Ala Arg Ala Phe Asn Thr Asp His Gln Thr Gln Leu Leu 
        195                 200                 205             


Tyr Gln Ala Ser Ala Met Met Val Glu Ser Arg Tyr Ala Leu Leu Ile 
    210                 215                 220                 


Val Asp Ser Ala Thr Ala Leu Tyr Arg Thr Asp Tyr Ser Gly Arg Gly 
225                 230                 235                 240 


Glu Leu Ser Ala Arg Gln Met His Leu Ala Arg Phe Leu Arg Met Leu 
                245                 250                 255     


Leu Arg Leu Ala Asp Glu Phe Gly Val Ala Val Val Ile Thr Asn Gln 
            260                 265                 270         


Val Val Ala Gln Val Asp Gly Ala Ala Met Phe Ala Ala Asp Pro Lys 
        275                 280                 285             


Lys Pro Ile Gly Gly Asn Ile Ile Ala His Ala Ser Thr Thr Arg Leu 
    290                 295                 300                 


Tyr Leu Arg Lys Gly Arg Gly Glu Thr Arg Ile Cys Lys Ile Tyr Asp 
305                 310                 315                 320 


Ser Pro Cys Leu Pro Glu Ala Glu Ala Met Phe Ala Ile Asn Ala Asp 
                325                 330                 335     


Gly Val Gly Asp Ala Lys Asp Ile Asp Gly Gly Gly Gly Ser Asp Pro 
            340                 345                 350         


Lys Lys Lys Arg Lys Val Asp Pro Lys Lys Lys Arg Lys Val Asp Pro 
        355                 360                 365             


Lys Lys Lys Arg Lys Val Gly Ser Thr Gly Ser Arg Asn Asp Gly Gly 
    370                 375                 380                 


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Arg Ala 
385                 390                 395                 400 


Gly Ile Leu Pro Pro Lys Lys Lys Arg Lys Val Ser Arg Gly Arg Ser 
                405                 410                 415     


Arg Leu Leu Glu Asp Phe Arg Asn Asn Arg Tyr Pro Asn Leu Gln Leu 
            420                 425                 430         


Arg Glu Ile Ala Gly His Ile Met Glu Phe Ser Gln Asp Gln His Gly 
        435                 440                 445             


Ser Arg Phe Ile Gln Leu Lys Leu Glu Arg Ala Thr Pro Ala Glu Arg 
    450                 455                 460                 


Gln Leu Val Phe Asn Glu Ile Leu Gln Ala Ala Tyr Gln Leu Met Val 
465                 470                 475                 480 


Asp Val Phe Gly Asn Tyr Val Ile Gln Lys Phe Phe Glu Phe Gly Ser 
                485                 490                 495     


Leu Glu Gln Lys Leu Ala Leu Ala Glu Arg Ile Arg Gly His Val Leu 
            500                 505                 510         


Ser Leu Ala Leu Gln Met Tyr Gly Ser Arg Val Ile Glu Lys Ala Leu 
        515                 520                 525             


Glu Phe Ile Pro Ser Asp Gln Gln Asn Glu Met Val Arg Glu Leu Asp 
    530                 535                 540                 


Gly His Val Leu Lys Cys Val Lys Asp Gln Asn Gly Asn His Val Val 
545                 550                 555                 560 


Gln Lys Cys Ile Glu Cys Val Gln Pro Gln Ser Leu Gln Phe Ile Ile 
                565                 570                 575     


Asp Ala Phe Lys Gly Gln Val Phe Ala Leu Ser Thr His Pro Tyr Gly 
            580                 585                 590         


Cys Arg Val Ile Gln Arg Ile Leu Glu His Cys Leu Pro Asp Gln Thr 
        595                 600                 605             


Leu Pro Ile Leu Glu Glu Leu His Gln His Thr Glu Gln Leu Val Gln 
    610                 615                 620                 


Asp Gln Tyr Gly Asn Tyr Val Ile Gln His Val Leu Glu His Gly Arg 
625                 630                 635                 640 


Pro Glu Asp Lys Ser Lys Ile Val Ala Glu Ile Arg Gly Asn Val Leu 
                645                 650                 655     


Val Leu Ser Gln His Lys Phe Ala Ser Asn Val Val Glu Lys Cys Val 
            660                 665                 670         


Thr His Ala Ser Arg Thr Glu Arg Ala Val Leu Ile Asp Glu Val Cys 
        675                 680                 685             


Thr Met Asn Asp Gly Pro His Ser Ala Leu Tyr Thr Met Met Lys Asp 
    690                 695                 700                 


Gln Tyr Ala Asn Tyr Val Val Gln Lys Met Ile Asp Val Ala Glu Pro 
705                 710                 715                 720 


Gly Gln Arg Lys Ile Val Met His Lys Ile Arg Pro His Ile Ala Thr 
                725                 730                 735     


Leu Arg Lys Tyr Thr Tyr Gly Lys His Ile Leu Ala Lys Leu Glu Lys 
            740                 745                 750         


Tyr Tyr Met Lys Asn Gly Val Asp Leu Gly Asp Pro Lys Lys Lys Arg 
        755                 760                 765             


Lys Val Asp Pro Lys Lys Lys Arg Lys Val Gly Gly Arg Gly Gly Gly 
    770                 775                 780                 


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Pro Ala 
785                 790                 795                 


<210>  55
<211>  5414
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide

<400>  55
tcaatattgg ccattagcca tattattcat tggttatata gcataaatca atattggcta       60

ttggccattg catacgttgt atctatatca taatatgtac atttatattg gctcatgtcc      120

aatatgaccg ccatgttggc attgattatt gactagttat taatagtaat caattacggg      180

gtcattagtt catagcccat atatggagtt ccgcgttaca taacttacgg taaatggccc      240

gcctggctga ccgcccaacg acccccgccc attgacgtca ataatgacgt atgttcccat      300

agtaacgcca atagggactt tccattgacg tcaatgggtg gagtatttac ggtaaactgc      360

ccacttggca gtacatcaag tgtatcatat gccaagtccg ccccctattg acgtcaatga      420

cggtaaatgg cccgcctggc attatgccca gtacatgacc ttacgggact ttcctacttg      480

gcagtacatc tacgtattag tcatcgctat taccatggtg atgcggtttt ggcagtacac      540

caatgggcgt ggatagcggt ttgactcacg gggatttcca agtctccacc ccattgacgt      600

caatgggagt ttgttttggc accaaaatca acgggacttt ccaaaatgtc gtaataaccc      660

cgccccgttg acgcaaatgg gcggtaggcg tgtacggtgg gaggtctata taagcagagg      720

tcgtttagtg aaccgtcaga tcactagtag ctttattgcg gtagtttatc acagttaaat      780

tgctaacgca gtcagtgctc gactgatcac aggtaagtat caaggttaca agacaggttt      840

aaggaggcca atagaaactg ggcttgtcga gacagagaag attcttgcgt ttctgatagg      900

cacctattgg tcttactgac atccactttg cctttctctc cacagggaaa aaacaattga      960

caagtttgta caaaaaagca ggctccgaat tcaccggtgc cgccaccatg gggccggcca     1020

tggatttgga tctactggac ctgaatccca gaattattgc tgcaattaag aaagccaaac     1080

tgaaatcggt aaaggaggtt ttacactttt ctggaccaga cttgaagaga ctgaccaacc     1140

tctccagccc cgaggtctgg cacttgctga gaacggcctc cttacacttg cggggaagca     1200

gcatccttac agcactgcag ctgcaccagc agaaggagcg gttccccacg cagcaccagc     1260

gcctgagcct gggctgcccg gtgctggacg cgctgctccg cggtggcctg cccctggacg     1320

gcatcactga gctggccgga cgcagctcgg cagggaagac ccagctggcg ctgcagctct     1380

gcctggctgt gcagttcccg cggcagcacg gaggcctgga ggctggagcc gtctacatct     1440

gcacggaaga cgccttcccg cacaagcgcc tgcagcagct catggcccag cagccgcggc     1500

tgcgcactga cgttccagga gagctgcttc agaagctccg atttggcagc cagatcttca     1560

tcgagcacgt ggccgatgtg gacaccttgt tggagtgtgt gaataagaag gtccccgtac     1620

tgctgtctcg gggcatggct cgcctggtgg tcatcgactc ggtggcagcc ccattccgct     1680

gtgaatttga cagccaggcc tccgccccca gggccaggca tctgcagtcc ctgggggcca     1740

cgctgcgtga gctgagcagt gccttccaga gccctgtgct gtgcatcaac caggtgacag     1800

aggccatgga ggagcagggc gcagcacacg ggccgctggg gttctgggac gaacgtgttt     1860

ccccagccct tggcataacc tgggctaacc agctcctggt gagactgctg gctgaccggc     1920

tccgcgagga agaggctgcc ctcggctgcc cagcccggac cctgcgggtg ctctctgccc     1980

cccacctgcc cccctcctcc tgttcctaca cgatcagtgc cgaaggggtg cgagggacac     2040

ctgggaccca gtcccacatc gatggcggag gcggatctga tccaaaaaag aagagaaagg     2100

tagatccaaa aaagaagaga aaggtagatc caaaaaagaa gagaaaggta ggatctaccg     2160

gatctagaaa cgatggtggt ggtggaagcg ggggtggggg cagcggtgga gggggaagcg     2220

ggcgcgccgg gatcctcccc cccaagaaaa agaggaaggt atctagaggc cgcagccgcc     2280

ttttggaaga ttttcgaaac aaccggtacc ccaatttaca actgcgggag attgctggac     2340

atataatgga attttcccaa gaccagcatg ggtccagatt cattcagctg aaactggagc     2400

gtgccacacc agctgagcgc cagcttgtct tcaatgaaat cctccaggct gcctaccaac     2460

tcatggtgga tgtgtttggt aattacgtca ttcagaagtt ctttgaattt ggcagtcttg     2520

aacagaagct ggctttggca gaacggattc gaggccacgt cctgtcattg gcactacaga     2580

tgtatggcag ccgtgttatc gagaaagctc ttgagtttat tccttcagac cagcagaatg     2640

agatggttcg ggaactagat ggccatgtct tgaagtgtgt gaaagatcag aatggcaatc     2700

acgtggttca gaaatgcatt gaatgtgtac agccccagtc tttgcaattt atcatcgacg     2760

cgtttaaggg acaggtattt gccttatcca cacatcctta tggctgccga gtgattcaga     2820

gaatcctgga gcactgtctc cctgaccaga cactccctat tttagaggag cttcaccagc     2880

acacagagca gctggtacag gatcaatatg gaaattatgt aatccaacat gtactggagc     2940

acggtcgtcc tgaggataaa agcaaaattg tagcagaaat ccgaggcaat gtacttgtat     3000

tgagtcagca caaatttgca agcaatgttg tggagaagtg tgttactcac gcctcacgta     3060

cggagcgcgc tgtgctcatc gacgaggtgt gcaccatgaa cgacggtccc cacagtgcct     3120

tatacaccat gatgaaggac cagtatgcca actacgtggt ccagaagatg attgacgtgg     3180

cggagccagg ccagcggaag atcgtcatgc ataagatccg gccccacatc gcaactcttc     3240

gtaagtacac ctatggcaag cacattctgg ccaagctgga gaagtactac atgaagaacg     3300

gtgttgactt aggggaccca aagaagaagc gcaaagtgga tcctaaaaag aaaagaaagg     3360

taggcggccg cgggggaggc ggttccggtg gcggcggaag cggaggtgga ggatcagggc     3420

cggcctgatt aattaagaat tcgacccagc tttcttgtac aaagtggttg atatccagca     3480

cagtggcggc cgctcgagtc tagagggccc gcggttcgaa ggtaagccta tccctaaccc     3540

tctcctcggt ctcgattcta cgcgtaccgg ttagcaattg ttttttcgat gagtttggac     3600

aaaccacaac tagaatgcag tgaaaaaaat gctttatttg tgaaatttgt gatgctattg     3660

ctttatttgt aaccattata agctgcaata aacaagttaa caacaacaat tgcattcatt     3720

ttatgtttca ggttcagggg gaggtgtggg aggtttttta aagcaagtaa aacctctaca     3780

aatgtggtac ttaagagggg gagaccaaag ggcgagacgt taaggcctca cgtgacatgt     3840

gagcaaaagg ccagcaaaag gccaggaacc gtaaaaaggc cgcgttgctg gcgtttttcc     3900

ataggctccg cccccctgac gagcatcaca aaaatcgacg ctcaagtcag aggtggcgaa     3960

acccgacagg actataaaga taccaggcgt ttccccctgg aagctccctc gtgcgctctc     4020

ctgttccgac cctgccgctt accggatacc tgtccgcctt tctcccttcg ggaagcgtgg     4080

cgctttctca tagctcacgc tgtaggtatc tcagttcggt gtaggtcgtt cgctccaagc     4140

tgggctgtgt gcacgaaccc cccgttcagc ccgaccgctg cgccttatcc ggtaactatc     4200

gtcttgagtc caacccggta agacacgact tatcgccact ggcagcagcc actggtaaca     4260

ggattagcag agcgaggtat gtaggcggtg ctacagagtt cttgaagtgg tggcctaact     4320

acggctacac tagaaggaca gtatttggta tctgcgctct gctgaagcca gttaccttcg     4380

gaaaaagagt tggtagctct tgatccggca aacaaaccac gctggtagcg gtggtttttt     4440

tgtttgcaag cagcagatta cgcgcagaaa aaaaggatct caagaagatc ctttgatctt     4500

ttctacgggg tctgacgctc agtggaacga aaactcacgt taagggattt tggtcatgcc     4560

gtctcagaag aactcgtcaa gaaggcgata gaaggcgatg cgctgcgaat cgggagcggc     4620

gataccgtaa agcacgagga agcggtcagc ccattcgccg ccaagctctt cagcaatatc     4680

acgggtagcc aacgctatgt cctgatagcg gtccgccaca cccagccggc cacagtcgat     4740

gaatccagaa aagcggccat tttccaccat gatattcggc aagcaggcat cgccatgggt     4800

cacgacgaga tcctcgccgt cgggcatgct cgccttgagc ctggcgaaca gttcggctgg     4860

cgcgagcccc tgatgctctt cgtccagatc atcctgatcg acaagaccgg cttccatccg     4920

agtacgtgct cgctcgatgc gatgtttcgc ttggtggtcg aatgggcagg tagccggatc     4980

aagcgtatgc agccgccgca ttgcatcagc catgatggat actttctcgg caggagcaag     5040

gtgagatgac aggagatcct gccccggcac ttcgcccaat agcagccagt cccttcccgc     5100

ttcagtgaca acgtcgagca cagctgcgca aggaacgccc gtcgtggcca gccacgatag     5160

ccgcgctgcc tcgtcttgca gttcattcag ggcaccggac aggtcggtct tgacaaaaag     5220

aaccgggcgc ccctgcgctg acagccggaa cacggcggca tcagagcagc cgattgtctg     5280

ttgtgcccag tcatagccga atagcctctc cacccaagcg gccggagaac ctgcgtgcaa     5340

tccatcttgt tcaatcataa tattattgaa gcatttatca gggttcgtct cgtcccggtc     5400

tcctcccatg catg                                                       5414


<210>  56
<211>  806
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  56

Met Gly Pro Ala Met Asp Leu Asp Leu Leu Asp Leu Asn Pro Arg Ile 
1               5                   10                  15      


Ile Ala Ala Ile Lys Lys Ala Lys Leu Lys Ser Val Lys Glu Val Leu 
            20                  25                  30          


His Phe Ser Gly Pro Asp Leu Lys Arg Leu Thr Asn Leu Ser Ser Pro 
        35                  40                  45              


Glu Val Trp His Leu Leu Arg Thr Ala Ser Leu His Leu Arg Gly Ser 
    50                  55                  60                  


Ser Ile Leu Thr Ala Leu Gln Leu His Gln Gln Lys Glu Arg Phe Pro 
65                  70                  75                  80  


Thr Gln His Gln Arg Leu Ser Leu Gly Cys Pro Val Leu Asp Ala Leu 
                85                  90                  95      


Leu Arg Gly Gly Leu Pro Leu Asp Gly Ile Thr Glu Leu Ala Gly Arg 
            100                 105                 110         


Ser Ser Ala Gly Lys Thr Gln Leu Ala Leu Gln Leu Cys Leu Ala Val 
        115                 120                 125             


Gln Phe Pro Arg Gln His Gly Gly Leu Glu Ala Gly Ala Val Tyr Ile 
    130                 135                 140                 


Cys Thr Glu Asp Ala Phe Pro His Lys Arg Leu Gln Gln Leu Met Ala 
145                 150                 155                 160 


Gln Gln Pro Arg Leu Arg Thr Asp Val Pro Gly Glu Leu Leu Gln Lys 
                165                 170                 175     


Leu Arg Phe Gly Ser Gln Ile Phe Ile Glu His Val Ala Asp Val Asp 
            180                 185                 190         


Thr Leu Leu Glu Cys Val Asn Lys Lys Val Pro Val Leu Leu Ser Arg 
        195                 200                 205             


Gly Met Ala Arg Leu Val Val Ile Asp Ser Val Ala Ala Pro Phe Arg 
    210                 215                 220                 


Cys Glu Phe Asp Ser Gln Ala Ser Ala Pro Arg Ala Arg His Leu Gln 
225                 230                 235                 240 


Ser Leu Gly Ala Thr Leu Arg Glu Leu Ser Ser Ala Phe Gln Ser Pro 
                245                 250                 255     


Val Leu Cys Ile Asn Gln Val Thr Glu Ala Met Glu Glu Gln Gly Ala 
            260                 265                 270         


Ala His Gly Pro Leu Gly Phe Trp Asp Glu Arg Val Ser Pro Ala Leu 
        275                 280                 285             


Gly Ile Thr Trp Ala Asn Gln Leu Leu Val Arg Leu Leu Ala Asp Arg 
    290                 295                 300                 


Leu Arg Glu Glu Glu Ala Ala Leu Gly Cys Pro Ala Arg Thr Leu Arg 
305                 310                 315                 320 


Val Leu Ser Ala Pro His Leu Pro Pro Ser Ser Cys Ser Tyr Thr Ile 
                325                 330                 335     


Ser Ala Glu Gly Val Arg Gly Thr Pro Gly Thr Gln Ser His Ile Asp 
            340                 345                 350         


Gly Gly Gly Gly Ser Asp Pro Lys Lys Lys Arg Lys Val Asp Pro Lys 
        355                 360                 365             


Lys Lys Arg Lys Val Asp Pro Lys Lys Lys Arg Lys Val Gly Ser Thr 
    370                 375                 380                 


Gly Ser Arg Asn Asp Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
385                 390                 395                 400 


Gly Gly Gly Ser Gly Arg Ala Gly Ile Leu Pro Pro Lys Lys Lys Arg 
                405                 410                 415     


Lys Val Ser Arg Gly Arg Ser Arg Leu Leu Glu Asp Phe Arg Asn Asn 
            420                 425                 430         


Arg Tyr Pro Asn Leu Gln Leu Arg Glu Ile Ala Gly His Ile Met Glu 
        435                 440                 445             


Phe Ser Gln Asp Gln His Gly Ser Arg Phe Ile Gln Leu Lys Leu Glu 
    450                 455                 460                 


Arg Ala Thr Pro Ala Glu Arg Gln Leu Val Phe Asn Glu Ile Leu Gln 
465                 470                 475                 480 


Ala Ala Tyr Gln Leu Met Val Asp Val Phe Gly Asn Tyr Val Ile Gln 
                485                 490                 495     


Lys Phe Phe Glu Phe Gly Ser Leu Glu Gln Lys Leu Ala Leu Ala Glu 
            500                 505                 510         


Arg Ile Arg Gly His Val Leu Ser Leu Ala Leu Gln Met Tyr Gly Ser 
        515                 520                 525             


Arg Val Ile Glu Lys Ala Leu Glu Phe Ile Pro Ser Asp Gln Gln Asn 
    530                 535                 540                 


Glu Met Val Arg Glu Leu Asp Gly His Val Leu Lys Cys Val Lys Asp 
545                 550                 555                 560 


Gln Asn Gly Asn His Val Val Gln Lys Cys Ile Glu Cys Val Gln Pro 
                565                 570                 575     


Gln Ser Leu Gln Phe Ile Ile Asp Ala Phe Lys Gly Gln Val Phe Ala 
            580                 585                 590         


Leu Ser Thr His Pro Tyr Gly Cys Arg Val Ile Gln Arg Ile Leu Glu 
        595                 600                 605             


His Cys Leu Pro Asp Gln Thr Leu Pro Ile Leu Glu Glu Leu His Gln 
    610                 615                 620                 


His Thr Glu Gln Leu Val Gln Asp Gln Tyr Gly Asn Tyr Val Ile Gln 
625                 630                 635                 640 


His Val Leu Glu His Gly Arg Pro Glu Asp Lys Ser Lys Ile Val Ala 
                645                 650                 655     


Glu Ile Arg Gly Asn Val Leu Val Leu Ser Gln His Lys Phe Ala Ser 
            660                 665                 670         


Asn Val Val Glu Lys Cys Val Thr His Ala Ser Arg Thr Glu Arg Ala 
        675                 680                 685             


Val Leu Ile Asp Glu Val Cys Thr Met Asn Asp Gly Pro His Ser Ala 
    690                 695                 700                 


Leu Tyr Thr Met Met Lys Asp Gln Tyr Ala Asn Tyr Val Val Gln Lys 
705                 710                 715                 720 


Met Ile Asp Val Ala Glu Pro Gly Gln Arg Lys Ile Val Met His Lys 
                725                 730                 735     


Ile Arg Pro His Ile Ala Thr Leu Arg Lys Tyr Thr Tyr Gly Lys His 
            740                 745                 750         


Ile Leu Ala Lys Leu Glu Lys Tyr Tyr Met Lys Asn Gly Val Asp Leu 
        755                 760                 765             


Gly Asp Pro Lys Lys Lys Arg Lys Val Asp Pro Lys Lys Lys Arg Lys 
    770                 775                 780                 


Val Gly Gly Arg Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
785                 790                 795                 800 


Gly Gly Ser Gly Pro Ala 
                805     


<210>  57
<211>  5411
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide

<400>  57
tcaatattgg ccattagcca tattattcat tggttatata gcataaatca atattggcta       60

ttggccattg catacgttgt atctatatca taatatgtac atttatattg gctcatgtcc      120

aatatgaccg ccatgttggc attgattatt gactagttat taatagtaat caattacggg      180

gtcattagtt catagcccat atatggagtt ccgcgttaca taacttacgg taaatggccc      240

gcctggctga ccgcccaacg acccccgccc attgacgtca ataatgacgt atgttcccat      300

agtaacgcca atagggactt tccattgacg tcaatgggtg gagtatttac ggtaaactgc      360

ccacttggca gtacatcaag tgtatcatat gccaagtccg ccccctattg acgtcaatga      420

cggtaaatgg cccgcctggc attatgccca gtacatgacc ttacgggact ttcctacttg      480

gcagtacatc tacgtattag tcatcgctat taccatggtg atgcggtttt ggcagtacac      540

caatgggcgt ggatagcggt ttgactcacg gggatttcca agtctccacc ccattgacgt      600

caatgggagt ttgttttggc accaaaatca acgggacttt ccaaaatgtc gtaataaccc      660

cgccccgttg acgcaaatgg gcggtaggcg tgtacggtgg gaggtctata taagcagagg      720

tcgtttagtg aaccgtcaga tcactagtag ctttattgcg gtagtttatc acagttaaat      780

tgctaacgca gtcagtgctc gactgatcac aggtaagtat caaggttaca agacaggttt      840

aaggaggcca atagaaactg ggcttgtcga gacagagaag attcttgcgt ttctgatagg      900

cacctattgg tcttactgac atccactttg cctttctctc cacagggaaa aaacaattga      960

caagtttgta caaaaaagca ggctccgaat tcaccggtgc cgccaccatg atcgatggcg     1020

gaggcggatc tgatccaaaa aagaagagaa aggtagatcc aaaaaagaag agaaaggtag     1080

atccaaaaaa gaagagaaag gtaggatcta ccggatctag aaacgatggt ggtggtggaa     1140

gcgggggtgg gggcagcggt ggagggggaa gcgggcgcgc cgggatcctc ccccccaaga     1200

aaaagaggaa ggtatctaga ggccgcagcc gccttttgga agattttcga aacaaccggt     1260

accccaattt acaactgcgg gagattgctg gacatataat ggaattttcc caagaccagc     1320

atgggtccag attcattcag ctgaaactgg agcgtgccac accagctgag cgccagcttg     1380

tcttcaatga aatcctccag gctgcctacc aactcatggt ggatgtgttt ggtaattacg     1440

tcattcagaa gttctttgaa tttggcagtc ttgaacagaa gctggctttg gcagaacgga     1500

ttcgaggcca cgtcctgtca ttggcactac agatgtatgg cagccgtgtt atcgagaaag     1560

ctcttgagtt tattccttca gaccagcaga atgagatggt tcgggaacta gatggccatg     1620

tcttgaagtg tgtgaaagat cagaatggca atcacgtggt tcagaaatgc attgaatgtg     1680

tacagcccca gtctttgcaa tttatcatcg acgcgtttaa gggacaggta tttgccttat     1740

ccacacatcc ttatggctgc cgagtgattc agagaatcct ggagcactgt ctccctgacc     1800

agacactccc tattttagag gagcttcacc agcacacaga gcagctggta caggatcaat     1860

atggaaatta tgtaatccaa catgtactgg agcacggtcg tcctgaggat aaaagcaaaa     1920

ttgtagcaga aatccgaggc aatgtacttg tattgagtca gcacaaattt gcaagcaatg     1980

ttgtggagaa gtgtgttact cacgcctcac gtacggagcg cgctgtgctc atcgacgagg     2040

tgtgcaccat gaacgacggt ccccacagtg ccttatacac catgatgaag gaccagtatg     2100

ccaactacgt ggtccagaag atgattgacg tggcggagcc aggccagcgg aagatcgtca     2160

tgcataagat ccggccccac atcgcaactc ttcgtaagta cacctatggc aagcacattc     2220

tggccaagct ggagaagtac tacatgaaga acggtgttga cttaggggac ccaaagaaga     2280

agcgcaaagt ggatcctaaa aagaaaagaa aggtaggcgg ccgcggggga ggcggttccg     2340

gtggcggcgg aagcggaggt ggaggatcag ggccggccat ggatttggat ctactggacc     2400

tgaatcccag aattattgct gcaattaaga aagccaaact gaaatcggta aaggaggttt     2460

tacacttttc tggaccagac ttgaagagac tgaccaacct ctccagcccc gaggtctggc     2520

acttgctgag aacggcctcc ttacacttgc ggggaagcag catccttaca gcactgcagc     2580

tgcaccagca gaaggagcgg ttccccacgc agcaccagcg cctgagcctg ggctgcccgg     2640

tgctggacgc gctgctccgc ggtggcctgc ccctggacgg catcactgag ctggccggac     2700

gcagctcggc agggaagacc cagctggcgc tgcagctctg cctggctgtg cagttcccgc     2760

ggcagcacgg aggcctggag gctggagccg tctacatctg cacggaagac gccttcccgc     2820

acaagcgcct gcagcagctc atggcccagc agccgcggct gcgcactgac gttccaggag     2880

agctgcttca gaagctccga tttggcagcc agatcttcat cgagcacgtg gccgatgtgg     2940

acaccttgtt ggagtgtgtg aataagaagg tccccgtact gctgtctcgg ggcatggctc     3000

gcctggtggt catcgactcg gtggcagccc cattccgctg tgaatttgac agccaggcct     3060

ccgcccccag ggccaggcat ctgcagtccc tgggggccac gctgcgtgag ctgagcagtg     3120

ccttccagag ccctgtgctg tgcatcaacc aggtgacaga ggccatggag gagcagggcg     3180

cagcacacgg gccgctgggg ttctgggacg aacgtgtttc cccagccctt ggcataacct     3240

gggctaacca gctcctggtg agactgctgg ctgaccggct ccgcgaggaa gaggctgccc     3300

tcggctgccc agcccggacc ctgcgggtgc tctctgcccc ccacctgccc ccctcctcct     3360

gttcctacac gatcagtgcc gaaggggtgc gagggacacc tgggacccag tcccacatcg     3420

attgattaat taagaattcg acccagcttt cttgtacaaa gtggttgata tccagcacag     3480

tggcggccgc tcgagtctag agggcccgcg gttcgaaggt aagcctatcc ctaaccctct     3540

cctcggtctc gattctacgc gtaccggtta gcaattgttt tttcgatgag tttggacaaa     3600

ccacaactag aatgcagtga aaaaaatgct ttatttgtga aatttgtgat gctattgctt     3660

tatttgtaac cattataagc tgcaataaac aagttaacaa caacaattgc attcatttta     3720

tgtttcaggt tcagggggag gtgtgggagg ttttttaaag caagtaaaac ctctacaaat     3780

gtggtactta agagggggag accaaagggc gagacgttaa ggcctcacgt gacatgtgag     3840

caaaaggcca gcaaaaggcc aggaaccgta aaaaggccgc gttgctggcg tttttccata     3900

ggctccgccc ccctgacgag catcacaaaa atcgacgctc aagtcagagg tggcgaaacc     3960

cgacaggact ataaagatac caggcgtttc cccctggaag ctccctcgtg cgctctcctg     4020

ttccgaccct gccgcttacc ggatacctgt ccgcctttct cccttcggga agcgtggcgc     4080

tttctcatag ctcacgctgt aggtatctca gttcggtgta ggtcgttcgc tccaagctgg     4140

gctgtgtgca cgaacccccc gttcagcccg accgctgcgc cttatccggt aactatcgtc     4200

ttgagtccaa cccggtaaga cacgacttat cgccactggc agcagccact ggtaacagga     4260

ttagcagagc gaggtatgta ggcggtgcta cagagttctt gaagtggtgg cctaactacg     4320

gctacactag aaggacagta tttggtatct gcgctctgct gaagccagtt accttcggaa     4380

aaagagttgg tagctcttga tccggcaaac aaaccacgct ggtagcggtg gtttttttgt     4440

ttgcaagcag cagattacgc gcagaaaaaa aggatctcaa gaagatcctt tgatcttttc     4500

tacggggtct gacgctcagt ggaacgaaaa ctcacgttaa gggattttgg tcatgccgtc     4560

tcagaagaac tcgtcaagaa ggcgatagaa ggcgatgcgc tgcgaatcgg gagcggcgat     4620

accgtaaagc acgaggaagc ggtcagccca ttcgccgcca agctcttcag caatatcacg     4680

ggtagccaac gctatgtcct gatagcggtc cgccacaccc agccggccac agtcgatgaa     4740

tccagaaaag cggccatttt ccaccatgat attcggcaag caggcatcgc catgggtcac     4800

gacgagatcc tcgccgtcgg gcatgctcgc cttgagcctg gcgaacagtt cggctggcgc     4860

gagcccctga tgctcttcgt ccagatcatc ctgatcgaca agaccggctt ccatccgagt     4920

acgtgctcgc tcgatgcgat gtttcgcttg gtggtcgaat gggcaggtag ccggatcaag     4980

cgtatgcagc cgccgcattg catcagccat gatggatact ttctcggcag gagcaaggtg     5040

agatgacagg agatcctgcc ccggcacttc gcccaatagc agccagtccc ttcccgcttc     5100

agtgacaacg tcgagcacag ctgcgcaagg aacgcccgtc gtggccagcc acgatagccg     5160

cgctgcctcg tcttgcagtt cattcagggc accggacagg tcggtcttga caaaaagaac     5220

cgggcgcccc tgcgctgaca gccggaacac ggcggcatca gagcagccga ttgtctgttg     5280

tgcccagtca tagccgaata gcctctccac ccaagcggcc ggagaacctg cgtgcaatcc     5340

atcttgttca atcataatat tattgaagca tttatcaggg ttcgtctcgt cccggtctcc     5400

tcccatgcat g                                                          5411


<210>  58
<211>  805
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  58

Met Ile Asp Gly Gly Gly Gly Ser Asp Pro Lys Lys Lys Arg Lys Val 
1               5                   10                  15      


Asp Pro Lys Lys Lys Arg Lys Val Asp Pro Lys Lys Lys Arg Lys Val 
            20                  25                  30          


Gly Ser Thr Gly Ser Arg Asn Asp Gly Gly Gly Gly Ser Gly Gly Gly 
        35                  40                  45              


Gly Ser Gly Gly Gly Gly Ser Gly Arg Ala Gly Ile Leu Pro Pro Lys 
    50                  55                  60                  


Lys Lys Arg Lys Val Ser Arg Gly Arg Ser Arg Leu Leu Glu Asp Phe 
65                  70                  75                  80  


Arg Asn Asn Arg Tyr Pro Asn Leu Gln Leu Arg Glu Ile Ala Gly His 
                85                  90                  95      


Ile Met Glu Phe Ser Gln Asp Gln His Gly Ser Arg Phe Ile Gln Leu 
            100                 105                 110         


Lys Leu Glu Arg Ala Thr Pro Ala Glu Arg Gln Leu Val Phe Asn Glu 
        115                 120                 125             


Ile Leu Gln Ala Ala Tyr Gln Leu Met Val Asp Val Phe Gly Asn Tyr 
    130                 135                 140                 


Val Ile Gln Lys Phe Phe Glu Phe Gly Ser Leu Glu Gln Lys Leu Ala 
145                 150                 155                 160 


Leu Ala Glu Arg Ile Arg Gly His Val Leu Ser Leu Ala Leu Gln Met 
                165                 170                 175     


Tyr Gly Ser Arg Val Ile Glu Lys Ala Leu Glu Phe Ile Pro Ser Asp 
            180                 185                 190         


Gln Gln Asn Glu Met Val Arg Glu Leu Asp Gly His Val Leu Lys Cys 
        195                 200                 205             


Val Lys Asp Gln Asn Gly Asn His Val Val Gln Lys Cys Ile Glu Cys 
    210                 215                 220                 


Val Gln Pro Gln Ser Leu Gln Phe Ile Ile Asp Ala Phe Lys Gly Gln 
225                 230                 235                 240 


Val Phe Ala Leu Ser Thr His Pro Tyr Gly Cys Arg Val Ile Gln Arg 
                245                 250                 255     


Ile Leu Glu His Cys Leu Pro Asp Gln Thr Leu Pro Ile Leu Glu Glu 
            260                 265                 270         


Leu His Gln His Thr Glu Gln Leu Val Gln Asp Gln Tyr Gly Asn Tyr 
        275                 280                 285             


Val Ile Gln His Val Leu Glu His Gly Arg Pro Glu Asp Lys Ser Lys 
    290                 295                 300                 


Ile Val Ala Glu Ile Arg Gly Asn Val Leu Val Leu Ser Gln His Lys 
305                 310                 315                 320 


Phe Ala Ser Asn Val Val Glu Lys Cys Val Thr His Ala Ser Arg Thr 
                325                 330                 335     


Glu Arg Ala Val Leu Ile Asp Glu Val Cys Thr Met Asn Asp Gly Pro 
            340                 345                 350         


His Ser Ala Leu Tyr Thr Met Met Lys Asp Gln Tyr Ala Asn Tyr Val 
        355                 360                 365             


Val Gln Lys Met Ile Asp Val Ala Glu Pro Gly Gln Arg Lys Ile Val 
    370                 375                 380                 


Met His Lys Ile Arg Pro His Ile Ala Thr Leu Arg Lys Tyr Thr Tyr 
385                 390                 395                 400 


Gly Lys His Ile Leu Ala Lys Leu Glu Lys Tyr Tyr Met Lys Asn Gly 
                405                 410                 415     


Val Asp Leu Gly Asp Pro Lys Lys Lys Arg Lys Val Asp Pro Lys Lys 
            420                 425                 430         


Lys Arg Lys Val Gly Gly Arg Gly Gly Gly Gly Ser Gly Gly Gly Gly 
        435                 440                 445             


Ser Gly Gly Gly Gly Ser Gly Pro Ala Met Asp Leu Asp Leu Leu Asp 
    450                 455                 460                 


Leu Asn Pro Arg Ile Ile Ala Ala Ile Lys Lys Ala Lys Leu Lys Ser 
465                 470                 475                 480 


Val Lys Glu Val Leu His Phe Ser Gly Pro Asp Leu Lys Arg Leu Thr 
                485                 490                 495     


Asn Leu Ser Ser Pro Glu Val Trp His Leu Leu Arg Thr Ala Ser Leu 
            500                 505                 510         


His Leu Arg Gly Ser Ser Ile Leu Thr Ala Leu Gln Leu His Gln Gln 
        515                 520                 525             


Lys Glu Arg Phe Pro Thr Gln His Gln Arg Leu Ser Leu Gly Cys Pro 
    530                 535                 540                 


Val Leu Asp Ala Leu Leu Arg Gly Gly Leu Pro Leu Asp Gly Ile Thr 
545                 550                 555                 560 


Glu Leu Ala Gly Arg Ser Ser Ala Gly Lys Thr Gln Leu Ala Leu Gln 
                565                 570                 575     


Leu Cys Leu Ala Val Gln Phe Pro Arg Gln His Gly Gly Leu Glu Ala 
            580                 585                 590         


Gly Ala Val Tyr Ile Cys Thr Glu Asp Ala Phe Pro His Lys Arg Leu 
        595                 600                 605             


Gln Gln Leu Met Ala Gln Gln Pro Arg Leu Arg Thr Asp Val Pro Gly 
    610                 615                 620                 


Glu Leu Leu Gln Lys Leu Arg Phe Gly Ser Gln Ile Phe Ile Glu His 
625                 630                 635                 640 


Val Ala Asp Val Asp Thr Leu Leu Glu Cys Val Asn Lys Lys Val Pro 
                645                 650                 655     


Val Leu Leu Ser Arg Gly Met Ala Arg Leu Val Val Ile Asp Ser Val 
            660                 665                 670         


Ala Ala Pro Phe Arg Cys Glu Phe Asp Ser Gln Ala Ser Ala Pro Arg 
        675                 680                 685             


Ala Arg His Leu Gln Ser Leu Gly Ala Thr Leu Arg Glu Leu Ser Ser 
    690                 695                 700                 


Ala Phe Gln Ser Pro Val Leu Cys Ile Asn Gln Val Thr Glu Ala Met 
705                 710                 715                 720 


Glu Glu Gln Gly Ala Ala His Gly Pro Leu Gly Phe Trp Asp Glu Arg 
                725                 730                 735     


Val Ser Pro Ala Leu Gly Ile Thr Trp Ala Asn Gln Leu Leu Val Arg 
            740                 745                 750         


Leu Leu Ala Asp Arg Leu Arg Glu Glu Glu Ala Ala Leu Gly Cys Pro 
        755                 760                 765             


Ala Arg Thr Leu Arg Val Leu Ser Ala Pro His Leu Pro Pro Ser Ser 
    770                 775                 780                 


Cys Ser Tyr Thr Ile Ser Ala Glu Gly Val Arg Gly Thr Pro Gly Thr 
785                 790                 795                 800 


Gln Ser His Ile Asp 
                805 


<210>  59
<211>  7349
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide

<400>  59
tcaatattgg ccattagcca tattattcat tggttatata gcataaatca atattggcta       60

ttggccattg catacgttgt atctatatca taatatgtac atttatattg gctcatgtcc      120

aatatgaccg ccatgttggc attgattatt gactagttat taatagtaat caattacggg      180

gtcattagtt catagcccat atatggagtt ccgcgttaca taacttacgg taaatggccc      240

gcctggctga ccgcccaacg acccccgccc attgacgtca ataatgacgt atgttcccat      300

agtaacgcca atagggactt tccattgacg tcaatgggtg gagtatttac ggtaaactgc      360

ccacttggca gtacatcaag tgtatcatat gccaagtccg ccccctattg acgtcaatga      420

cggtaaatgg cccgcctggc attatgccca gtacatgacc ttacgggact ttcctacttg      480

gcagtacatc tacgtattag tcatcgctat taccatggtg atgcggtttt ggcagtacac      540

caatgggcgt ggatagcggt ttgactcacg gggatttcca agtctccacc ccattgacgt      600

caatgggagt ttgttttggc accaaaatca acgggacttt ccaaaatgtc gtaataaccc      660

cgccccgttg acgcaaatgg gcggtaggcg tgtacggtgg gaggtctata taagcagagg      720

tcgtttagtg aaccgtcaga tcactagtag ctttattgcg gtagtttatc acagttaaat      780

tgctaacgca gtcagtgctc gactgatcac aggtaagtat caaggttaca agacaggttt      840

aaggaggcca atagaaactg ggcttgtcga gacagagaag attcttgcgt ttctgatagg      900

cacctattgg tcttactgac atccactttg cctttctctc cacagggaaa aaacaattga      960

caagtttgta caaaaaagca ggctccgaat tcaccggtgc cgccaccatg gggccggcca     1020

tgagcagcca ccataccacc tttccttttg accctgagcg gcgagtccgg agtacgctga     1080

agaaggtctt tgggtttgac tcttttaaga cgcctttaca ggagagtgcg accatggctg     1140

tagtaaaagg taacaaggac gtctttgtgt gcatgcccac aggggcagga aaatccctat     1200

gctatcagct ccctgctctg ttggccaaag gcatcaccat tgtagtctct cctctcattg     1260

ctttgattca ggaccaagtg gaccacttgc taaccctaaa ggtacgagta agttccctga     1320

actcgaagct ctctgcacag gaaaggaagg agctgcttgc tgacctggag cgagaaaagc     1380

cccagaccaa gattctgtac atcaccccag agatggcagc ttcatcctcc ttccagccca     1440

ccctgaactc cctggtgtcc cgccacctgc tgtcttactt ggtggtggat gaagctcatt     1500

gtgtttccca atgggggcat gactttcgtc ctgactactt gcgtctgggt gccctgcgct     1560

cccgcctggg acatgcccct tgtgtggctc tgaccgccac agccacccca caggtccaag     1620

aggacgtgtt tgctgccctg cacctgaaga aaccagttgc catcttcaag actccctgct     1680

tccgggccaa cctcttctat gatgtgcaat tcaaggaact gatttctgat ccctatggga     1740

acctgaagga cttctgcctt aaggctcttg gacaggaggc tgataaaggg ttatctggct     1800

gcggcattgt gtactgcagg actagagagg cttgtgaaca gctggccata gagctcagct     1860

gcaggggtgt gaacgccaag gcttaccatg cagggctgaa ggcctctgaa agaacgctgg     1920

tgcagaacga ctggatggag gagaaggtcc ctgtaattgt tgcaaccatt agttttggga     1980

tgggagtgga taaagccaat gtcaggtttg tcgcccattg gaatattgcc aagtctatgg     2040

ctgggtacta ccaggagtct ggccgggctg gcagggatgg gaagccttcc tggtgccgtc     2100

tctattactc caggaatgac cgggaccaag tcagcttcct gatcaggaag gaagtagcaa     2160

aactccagga aaagagagga aacaaagcat ctgataaagc cactatcatg gcctttgatg     2220

ccctggtgac cttctgtgaa gaactggggt gccgccatgc cgccattgcc aagtacttcg     2280

gggatgcgct gcctgcctgc gccaaaggct gcgaccactg ccagaacccc acggccgtgc     2340

ggaggcggct ggaggccttg gagcgcagca gcagctggag caagacctgc atcgggccct     2400

cccaggggaa cggctttgac cccgagctgt acgagggagg ccgcaagggc tacggggact     2460

tcagcaggta tgacgaaggt tctggaggca gcggggatga aggcagagat gaggcccaca     2520

agcgggagtg gaacctcttc tatcagaagc agatgcagct gcgcaagggc aaagacccca     2580

agatagaaga atttgtaccc ccagatgaga actgtcccct gaaagaggct tctagcagga     2640

ggatccccag gctgactgtg aaggcacggg agcactgcct gcggcttctg gaggaggcgc     2700

tgagcagcaa ccgccagtca acacgtaccg ctgatgaagc tgacctccgg gccaaggccg     2760

tggagctgga acatgagaca ttccggaacg ccaaggtggc caacctctac aaggccagcg     2820

tgctgaagaa ggtggccgat atccacagag cctccaagga tgggcagccc tatgacatgg     2880

gaggcagtgc caagagctgc agtgcccaag ctgagccccc ggagcccaat gagtatgaca     2940

ttccaccagc ctcccatgtg tactcgctca aacccaagcg ggtgggagct ggtttcccca     3000

aaggctcctg cccgttccag acggccacgg aactgatgga gacgactcgg atcagggagc     3060

aagcccccca gcccgagcgg ggaggcgagc atgagccccc gagccggccc tgtggcctcc     3120

tggatgagga tgggagtgag cccctccctg ggcccagagg ggaggtccct ggaggcagcg     3180

ctcactatgg ggggccctcc cctgagaaga aggcaaaaag ttcctctggg ggcagctccc     3240

ttgccaaggg ccgggctagc aagaaacagc agctcctagc cacagcggcc cacaaggatt     3300

ctcagagcat cgcccgcttc ttctgccgaa gggtggaaag cccagctctg ctggcatcag     3360

ccccagaggc agaaggtgcc tgcccctcct gtgagggggt tcagggaccc ccgatggccc     3420

cagagaagta cacaggggag gaagatggag ccgggggaca ttcgcctgcc cctccccaga     3480

ctgaggagtg cctcagggag aggccaagca cctgcccgcc cagagaccag ggcacccctg     3540

aagtccagcc cacccctgca aaggacacat ggaagggcaa gcggcctcga tcccagcagg     3600

agaacccaga gagccagcct cagaagaggc cacgcccctc agccaagccc tccgtcgtag     3660

ctgaggtcaa gggcagcgtc tcggccagcg aacagggcac cttgaatccc acggctcaag     3720

accccttcca gctctccgct cctggcgtct ccttgaagga ggctgcaaat gttgtggtca     3780

agtgcctcac ccctttctac aaggagggca agtttgcttc caaggagttg tttaaaggct     3840

ttgcccgcca cctctcacac ttgctgactc agaagacctc tcctggaagg agcgtgaaag     3900

aagaggccca gaacctcatc aggcacttct tccatggccg ggcccggtgc gagagcgaag     3960

ctgactggca tggcctgtgt ggcccccaga gaatcgatgg cggaggcgga tctgatccaa     4020

aaaagaagag aaaggtagat ccaaaaaaga agagaaaggt agatccaaaa aagaagagaa     4080

aggtaggatc taccggatct agaaacgatg gtggtggtgg aagcgggggt gggggcagcg     4140

gtggaggggg aagcgggcgc gccgggatcc tcccccccaa gaaaaagagg aaggtatcta     4200

gaggccgcag ccgccttttg gaagattttc gaaacaaccg gtaccccaat ttacaactgc     4260

gggagattgc tggacatata atggaatttt cccaagacca gcatgggtcc agattcattc     4320

agctgaaact ggagcgtgcc acaccagctg agcgccagct tgtcttcaat gaaatcctcc     4380

aggctgccta ccaactcatg gtggatgtgt ttggtaatta cgtcattcag aagttctttg     4440

aatttggcag tcttgaacag aagctggctt tggcagaacg gattcgaggc cacgtcctgt     4500

cattggcact acagatgtat ggcagccgtg ttatcgagaa agctcttgag tttattcctt     4560

cagaccagca gaatgagatg gttcgggaac tagatggcca tgtcttgaag tgtgtgaaag     4620

atcagaatgg caatcacgtg gttcagaaat gcattgaatg tgtacagccc cagtctttgc     4680

aatttatcat cgacgcgttt aagggacagg tatttgcctt atccacacat ccttatggct     4740

gccgagtgat tcagagaatc ctggagcact gtctccctga ccagacactc cctattttag     4800

aggagcttca ccagcacaca gagcagctgg tacaggatca atatggaaat tatgtaatcc     4860

aacatgtact ggagcacggt cgtcctgagg ataaaagcaa aattgtagca gaaatccgag     4920

gcaatgtact tgtattgagt cagcacaaat ttgcaagcaa tgttgtggag aagtgtgtta     4980

ctcacgcctc acgtacggag cgcgctgtgc tcatcgacga ggtgtgcacc atgaacgacg     5040

gtccccacag tgccttatac accatgatga aggaccagta tgccaactac gtggtccaga     5100

agatgattga cgtggcggag ccaggccagc ggaagatcgt catgcataag atccggcccc     5160

acatcgcaac tcttcgtaag tacacctatg gcaagcacat tctggccaag ctggagaagt     5220

actacatgaa gaacggtgtt gacttagggg acccaaagaa gaagcgcaaa gtggatccta     5280

aaaagaaaag aaaggtaggc ggccgcgggg gaggcggttc cggtggcggc ggaagcggag     5340

gtggaggatc agggccggcc tgattaatta agaattcgac ccagctttct tgtacaaagt     5400

ggttgatatc cagcacagtg gcggccgctc gagtctagag ggcccgcggt tcgaaggtaa     5460

gcctatccct aaccctctcc tcggtctcga ttctacgcgt accggttagc aattgttttt     5520

tcgatgagtt tggacaaacc acaactagaa tgcagtgaaa aaaatgcttt atttgtgaaa     5580

tttgtgatgc tattgcttta tttgtaacca ttataagctg caataaacaa gttaacaaca     5640

acaattgcat tcattttatg tttcaggttc agggggaggt gtgggaggtt ttttaaagca     5700

agtaaaacct ctacaaatgt ggtacttaag agggggagac caaagggcga gacgttaagg     5760

cctcacgtga catgtgagca aaaggccagc aaaaggccag gaaccgtaaa aaggccgcgt     5820

tgctggcgtt tttccatagg ctccgccccc ctgacgagca tcacaaaaat cgacgctcaa     5880

gtcagaggtg gcgaaacccg acaggactat aaagatacca ggcgtttccc cctggaagct     5940

ccctcgtgcg ctctcctgtt ccgaccctgc cgcttaccgg atacctgtcc gcctttctcc     6000

cttcgggaag cgtggcgctt tctcatagct cacgctgtag gtatctcagt tcggtgtagg     6060

tcgttcgctc caagctgggc tgtgtgcacg aaccccccgt tcagcccgac cgctgcgcct     6120

tatccggtaa ctatcgtctt gagtccaacc cggtaagaca cgacttatcg ccactggcag     6180

cagccactgg taacaggatt agcagagcga ggtatgtagg cggtgctaca gagttcttga     6240

agtggtggcc taactacggc tacactagaa ggacagtatt tggtatctgc gctctgctga     6300

agccagttac cttcggaaaa agagttggta gctcttgatc cggcaaacaa accacgctgg     6360

tagcggtggt ttttttgttt gcaagcagca gattacgcgc agaaaaaaag gatctcaaga     6420

agatcctttg atcttttcta cggggtctga cgctcagtgg aacgaaaact cacgttaagg     6480

gattttggtc atgccgtctc agaagaactc gtcaagaagg cgatagaagg cgatgcgctg     6540

cgaatcggga gcggcgatac cgtaaagcac gaggaagcgg tcagcccatt cgccgccaag     6600

ctcttcagca atatcacggg tagccaacgc tatgtcctga tagcggtccg ccacacccag     6660

ccggccacag tcgatgaatc cagaaaagcg gccattttcc accatgatat tcggcaagca     6720

ggcatcgcca tgggtcacga cgagatcctc gccgtcgggc atgctcgcct tgagcctggc     6780

gaacagttcg gctggcgcga gcccctgatg ctcttcgtcc agatcatcct gatcgacaag     6840

accggcttcc atccgagtac gtgctcgctc gatgcgatgt ttcgcttggt ggtcgaatgg     6900

gcaggtagcc ggatcaagcg tatgcagccg ccgcattgca tcagccatga tggatacttt     6960

ctcggcagga gcaaggtgag atgacaggag atcctgcccc ggcacttcgc ccaatagcag     7020

ccagtccctt cccgcttcag tgacaacgtc gagcacagct gcgcaaggaa cgcccgtcgt     7080

ggccagccac gatagccgcg ctgcctcgtc ttgcagttca ttcagggcac cggacaggtc     7140

ggtcttgaca aaaagaaccg ggcgcccctg cgctgacagc cggaacacgg cggcatcaga     7200

gcagccgatt gtctgttgtg cccagtcata gccgaatagc ctctccaccc aagcggccgg     7260

agaacctgcg tgcaatccat cttgttcaat cataatatta ttgaagcatt tatcagggtt     7320

cgtctcgtcc cggtctcctc ccatgcatg                                       7349


<210>  60
<211>  1451
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  60

Met Gly Pro Ala Met Ser Ser His His Thr Thr Phe Pro Phe Asp Pro 
1               5                   10                  15      


Glu Arg Arg Val Arg Ser Thr Leu Lys Lys Val Phe Gly Phe Asp Ser 
            20                  25                  30          


Phe Lys Thr Pro Leu Gln Glu Ser Ala Thr Met Ala Val Val Lys Gly 
        35                  40                  45              


Asn Lys Asp Val Phe Val Cys Met Pro Thr Gly Ala Gly Lys Ser Leu 
    50                  55                  60                  


Cys Tyr Gln Leu Pro Ala Leu Leu Ala Lys Gly Ile Thr Ile Val Val 
65                  70                  75                  80  


Ser Pro Leu Ile Ala Leu Ile Gln Asp Gln Val Asp His Leu Leu Thr 
                85                  90                  95      


Leu Lys Val Arg Val Ser Ser Leu Asn Ser Lys Leu Ser Ala Gln Glu 
            100                 105                 110         


Arg Lys Glu Leu Leu Ala Asp Leu Glu Arg Glu Lys Pro Gln Thr Lys 
        115                 120                 125             


Ile Leu Tyr Ile Thr Pro Glu Met Ala Ala Ser Ser Ser Phe Gln Pro 
    130                 135                 140                 


Thr Leu Asn Ser Leu Val Ser Arg His Leu Leu Ser Tyr Leu Val Val 
145                 150                 155                 160 


Asp Glu Ala His Cys Val Ser Gln Trp Gly His Asp Phe Arg Pro Asp 
                165                 170                 175     


Tyr Leu Arg Leu Gly Ala Leu Arg Ser Arg Leu Gly His Ala Pro Cys 
            180                 185                 190         


Val Ala Leu Thr Ala Thr Ala Thr Pro Gln Val Gln Glu Asp Val Phe 
        195                 200                 205             


Ala Ala Leu His Leu Lys Lys Pro Val Ala Ile Phe Lys Thr Pro Cys 
    210                 215                 220                 


Phe Arg Ala Asn Leu Phe Tyr Asp Val Gln Phe Lys Glu Leu Ile Ser 
225                 230                 235                 240 


Asp Pro Tyr Gly Asn Leu Lys Asp Phe Cys Leu Lys Ala Leu Gly Gln 
                245                 250                 255     


Glu Ala Asp Lys Gly Leu Ser Gly Cys Gly Ile Val Tyr Cys Arg Thr 
            260                 265                 270         


Arg Glu Ala Cys Glu Gln Leu Ala Ile Glu Leu Ser Cys Arg Gly Val 
        275                 280                 285             


Asn Ala Lys Ala Tyr His Ala Gly Leu Lys Ala Ser Glu Arg Thr Leu 
    290                 295                 300                 


Val Gln Asn Asp Trp Met Glu Glu Lys Val Pro Val Ile Val Ala Thr 
305                 310                 315                 320 


Ile Ser Phe Gly Met Gly Val Asp Lys Ala Asn Val Arg Phe Val Ala 
                325                 330                 335     


His Trp Asn Ile Ala Lys Ser Met Ala Gly Tyr Tyr Gln Glu Ser Gly 
            340                 345                 350         


Arg Ala Gly Arg Asp Gly Lys Pro Ser Trp Cys Arg Leu Tyr Tyr Ser 
        355                 360                 365             


Arg Asn Asp Arg Asp Gln Val Ser Phe Leu Ile Arg Lys Glu Val Ala 
    370                 375                 380                 


Lys Leu Gln Glu Lys Arg Gly Asn Lys Ala Ser Asp Lys Ala Thr Ile 
385                 390                 395                 400 


Met Ala Phe Asp Ala Leu Val Thr Phe Cys Glu Glu Leu Gly Cys Arg 
                405                 410                 415     


His Ala Ala Ile Ala Lys Tyr Phe Gly Asp Ala Leu Pro Ala Cys Ala 
            420                 425                 430         


Lys Gly Cys Asp His Cys Gln Asn Pro Thr Ala Val Arg Arg Arg Leu 
        435                 440                 445             


Glu Ala Leu Glu Arg Ser Ser Ser Trp Ser Lys Thr Cys Ile Gly Pro 
    450                 455                 460                 


Ser Gln Gly Asn Gly Phe Asp Pro Glu Leu Tyr Glu Gly Gly Arg Lys 
465                 470                 475                 480 


Gly Tyr Gly Asp Phe Ser Arg Tyr Asp Glu Gly Ser Gly Gly Ser Gly 
                485                 490                 495     


Asp Glu Gly Arg Asp Glu Ala His Lys Arg Glu Trp Asn Leu Phe Tyr 
            500                 505                 510         


Gln Lys Gln Met Gln Leu Arg Lys Gly Lys Asp Pro Lys Ile Glu Glu 
        515                 520                 525             


Phe Val Pro Pro Asp Glu Asn Cys Pro Leu Lys Glu Ala Ser Ser Arg 
    530                 535                 540                 


Arg Ile Pro Arg Leu Thr Val Lys Ala Arg Glu His Cys Leu Arg Leu 
545                 550                 555                 560 


Leu Glu Glu Ala Leu Ser Ser Asn Arg Gln Ser Thr Arg Thr Ala Asp 
                565                 570                 575     


Glu Ala Asp Leu Arg Ala Lys Ala Val Glu Leu Glu His Glu Thr Phe 
            580                 585                 590         


Arg Asn Ala Lys Val Ala Asn Leu Tyr Lys Ala Ser Val Leu Lys Lys 
        595                 600                 605             


Val Ala Asp Ile His Arg Ala Ser Lys Asp Gly Gln Pro Tyr Asp Met 
    610                 615                 620                 


Gly Gly Ser Ala Lys Ser Cys Ser Ala Gln Ala Glu Pro Pro Glu Pro 
625                 630                 635                 640 


Asn Glu Tyr Asp Ile Pro Pro Ala Ser His Val Tyr Ser Leu Lys Pro 
                645                 650                 655     


Lys Arg Val Gly Ala Gly Phe Pro Lys Gly Ser Cys Pro Phe Gln Thr 
            660                 665                 670         


Ala Thr Glu Leu Met Glu Thr Thr Arg Ile Arg Glu Gln Ala Pro Gln 
        675                 680                 685             


Pro Glu Arg Gly Gly Glu His Glu Pro Pro Ser Arg Pro Cys Gly Leu 
    690                 695                 700                 


Leu Asp Glu Asp Gly Ser Glu Pro Leu Pro Gly Pro Arg Gly Glu Val 
705                 710                 715                 720 


Pro Gly Gly Ser Ala His Tyr Gly Gly Pro Ser Pro Glu Lys Lys Ala 
                725                 730                 735     


Lys Ser Ser Ser Gly Gly Ser Ser Leu Ala Lys Gly Arg Ala Ser Lys 
            740                 745                 750         


Lys Gln Gln Leu Leu Ala Thr Ala Ala His Lys Asp Ser Gln Ser Ile 
        755                 760                 765             


Ala Arg Phe Phe Cys Arg Arg Val Glu Ser Pro Ala Leu Leu Ala Ser 
    770                 775                 780                 


Ala Pro Glu Ala Glu Gly Ala Cys Pro Ser Cys Glu Gly Val Gln Gly 
785                 790                 795                 800 


Pro Pro Met Ala Pro Glu Lys Tyr Thr Gly Glu Glu Asp Gly Ala Gly 
                805                 810                 815     


Gly His Ser Pro Ala Pro Pro Gln Thr Glu Glu Cys Leu Arg Glu Arg 
            820                 825                 830         


Pro Ser Thr Cys Pro Pro Arg Asp Gln Gly Thr Pro Glu Val Gln Pro 
        835                 840                 845             


Thr Pro Ala Lys Asp Thr Trp Lys Gly Lys Arg Pro Arg Ser Gln Gln 
    850                 855                 860                 


Glu Asn Pro Glu Ser Gln Pro Gln Lys Arg Pro Arg Pro Ser Ala Lys 
865                 870                 875                 880 


Pro Ser Val Val Ala Glu Val Lys Gly Ser Val Ser Ala Ser Glu Gln 
                885                 890                 895     


Gly Thr Leu Asn Pro Thr Ala Gln Asp Pro Phe Gln Leu Ser Ala Pro 
            900                 905                 910         


Gly Val Ser Leu Lys Glu Ala Ala Asn Val Val Val Lys Cys Leu Thr 
        915                 920                 925             


Pro Phe Tyr Lys Glu Gly Lys Phe Ala Ser Lys Glu Leu Phe Lys Gly 
    930                 935                 940                 


Phe Ala Arg His Leu Ser His Leu Leu Thr Gln Lys Thr Ser Pro Gly 
945                 950                 955                 960 


Arg Ser Val Lys Glu Glu Ala Gln Asn Leu Ile Arg His Phe Phe His 
                965                 970                 975     


Gly Arg Ala Arg Cys Glu Ser Glu Ala Asp Trp His Gly Leu Cys Gly 
            980                 985                 990         


Pro Gln Arg Ile Asp Gly Gly Gly  Gly Ser Asp Pro Lys  Lys Lys Arg 
        995                 1000                 1005             


Lys Val  Asp Pro Lys Lys Lys  Arg Lys Val Asp Pro  Lys Lys Lys 
    1010                 1015                 1020             


Arg Lys  Val Gly Ser Thr Gly  Ser Arg Asn Asp Gly  Gly Gly Gly 
    1025                 1030                 1035             


Ser Gly  Gly Gly Gly Ser Gly  Gly Gly Gly Ser Gly  Arg Ala Gly 
    1040                 1045                 1050             


Ile Leu  Pro Pro Lys Lys Lys  Arg Lys Val Ser Arg  Gly Arg Ser 
    1055                 1060                 1065             


Arg Leu  Leu Glu Asp Phe Arg  Asn Asn Arg Tyr Pro  Asn Leu Gln 
    1070                 1075                 1080             


Leu Arg  Glu Ile Ala Gly His  Ile Met Glu Phe Ser  Gln Asp Gln 
    1085                 1090                 1095             


His Gly  Ser Arg Phe Ile Gln  Leu Lys Leu Glu Arg  Ala Thr Pro 
    1100                 1105                 1110             


Ala Glu  Arg Gln Leu Val Phe  Asn Glu Ile Leu Gln  Ala Ala Tyr 
    1115                 1120                 1125             


Gln Leu  Met Val Asp Val Phe  Gly Asn Tyr Val Ile  Gln Lys Phe 
    1130                 1135                 1140             


Phe Glu  Phe Gly Ser Leu Glu  Gln Lys Leu Ala Leu  Ala Glu Arg 
    1145                 1150                 1155             


Ile Arg  Gly His Val Leu Ser  Leu Ala Leu Gln Met  Tyr Gly Ser 
    1160                 1165                 1170             


Arg Val  Ile Glu Lys Ala Leu  Glu Phe Ile Pro Ser  Asp Gln Gln 
    1175                 1180                 1185             


Asn Glu  Met Val Arg Glu Leu  Asp Gly His Val Leu  Lys Cys Val 
    1190                 1195                 1200             


Lys Asp  Gln Asn Gly Asn His  Val Val Gln Lys Cys  Ile Glu Cys 
    1205                 1210                 1215             


Val Gln  Pro Gln Ser Leu Gln  Phe Ile Ile Asp Ala  Phe Lys Gly 
    1220                 1225                 1230             


Gln Val  Phe Ala Leu Ser Thr  His Pro Tyr Gly Cys  Arg Val Ile 
    1235                 1240                 1245             


Gln Arg  Ile Leu Glu His Cys  Leu Pro Asp Gln Thr  Leu Pro Ile 
    1250                 1255                 1260             


Leu Glu  Glu Leu His Gln His  Thr Glu Gln Leu Val  Gln Asp Gln 
    1265                 1270                 1275             


Tyr Gly  Asn Tyr Val Ile Gln  His Val Leu Glu His  Gly Arg Pro 
    1280                 1285                 1290             


Glu Asp  Lys Ser Lys Ile Val  Ala Glu Ile Arg Gly  Asn Val Leu 
    1295                 1300                 1305             


Val Leu  Ser Gln His Lys Phe  Ala Ser Asn Val Val  Glu Lys Cys 
    1310                 1315                 1320             


Val Thr  His Ala Ser Arg Thr  Glu Arg Ala Val Leu  Ile Asp Glu 
    1325                 1330                 1335             


Val Cys  Thr Met Asn Asp Gly  Pro His Ser Ala Leu  Tyr Thr Met 
    1340                 1345                 1350             


Met Lys  Asp Gln Tyr Ala Asn  Tyr Val Val Gln Lys  Met Ile Asp 
    1355                 1360                 1365             


Val Ala  Glu Pro Gly Gln Arg  Lys Ile Val Met His  Lys Ile Arg 
    1370                 1375                 1380             


Pro His  Ile Ala Thr Leu Arg  Lys Tyr Thr Tyr Gly  Lys His Ile 
    1385                 1390                 1395             


Leu Ala  Lys Leu Glu Lys Tyr  Tyr Met Lys Asn Gly  Val Asp Leu 
    1400                 1405                 1410             


Gly Asp  Pro Lys Lys Lys Arg  Lys Val Asp Pro Lys  Lys Lys Arg 
    1415                 1420                 1425             


Lys Val  Gly Gly Arg Gly Gly  Gly Gly Ser Gly Gly  Gly Gly Ser 
    1430                 1435                 1440             


Gly Gly  Gly Gly Ser Gly Pro  Ala 
    1445                 1450     


<210>  61
<211>  7346
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide

<400>  61
tcaatattgg ccattagcca tattattcat tggttatata gcataaatca atattggcta       60

ttggccattg catacgttgt atctatatca taatatgtac atttatattg gctcatgtcc      120

aatatgaccg ccatgttggc attgattatt gactagttat taatagtaat caattacggg      180

gtcattagtt catagcccat atatggagtt ccgcgttaca taacttacgg taaatggccc      240

gcctggctga ccgcccaacg acccccgccc attgacgtca ataatgacgt atgttcccat      300

agtaacgcca atagggactt tccattgacg tcaatgggtg gagtatttac ggtaaactgc      360

ccacttggca gtacatcaag tgtatcatat gccaagtccg ccccctattg acgtcaatga      420

cggtaaatgg cccgcctggc attatgccca gtacatgacc ttacgggact ttcctacttg      480

gcagtacatc tacgtattag tcatcgctat taccatggtg atgcggtttt ggcagtacac      540

caatgggcgt ggatagcggt ttgactcacg gggatttcca agtctccacc ccattgacgt      600

caatgggagt ttgttttggc accaaaatca acgggacttt ccaaaatgtc gtaataaccc      660

cgccccgttg acgcaaatgg gcggtaggcg tgtacggtgg gaggtctata taagcagagg      720

tcgtttagtg aaccgtcaga tcactagtag ctttattgcg gtagtttatc acagttaaat      780

tgctaacgca gtcagtgctc gactgatcac aggtaagtat caaggttaca agacaggttt      840

aaggaggcca atagaaactg ggcttgtcga gacagagaag attcttgcgt ttctgatagg      900

cacctattgg tcttactgac atccactttg cctttctctc cacagggaaa aaacaattga      960

caagtttgta caaaaaagca ggctccgaat tcaccggtgc cgccaccatg atcgatggcg     1020

gaggcggatc tgatccaaaa aagaagagaa aggtagatcc aaaaaagaag agaaaggtag     1080

atccaaaaaa gaagagaaag gtaggatcta ccggatctag aaacgatggt ggtggtggaa     1140

gcgggggtgg gggcagcggt ggagggggaa gcgggcgcgc cgggatcctc ccccccaaga     1200

aaaagaggaa ggtatctaga ggccgcagcc gccttttgga agattttcga aacaaccggt     1260

accccaattt acaactgcgg gagattgctg gacatataat ggaattttcc caagaccagc     1320

atgggtccag attcattcag ctgaaactgg agcgtgccac accagctgag cgccagcttg     1380

tcttcaatga aatcctccag gctgcctacc aactcatggt ggatgtgttt ggtaattacg     1440

tcattcagaa gttctttgaa tttggcagtc ttgaacagaa gctggctttg gcagaacgga     1500

ttcgaggcca cgtcctgtca ttggcactac agatgtatgg cagccgtgtt atcgagaaag     1560

ctcttgagtt tattccttca gaccagcaga atgagatggt tcgggaacta gatggccatg     1620

tcttgaagtg tgtgaaagat cagaatggca atcacgtggt tcagaaatgc attgaatgtg     1680

tacagcccca gtctttgcaa tttatcatcg acgcgtttaa gggacaggta tttgccttat     1740

ccacacatcc ttatggctgc cgagtgattc agagaatcct ggagcactgt ctccctgacc     1800

agacactccc tattttagag gagcttcacc agcacacaga gcagctggta caggatcaat     1860

atggaaatta tgtaatccaa catgtactgg agcacggtcg tcctgaggat aaaagcaaaa     1920

ttgtagcaga aatccgaggc aatgtacttg tattgagtca gcacaaattt gcaagcaatg     1980

ttgtggagaa gtgtgttact cacgcctcac gtacggagcg cgctgtgctc atcgacgagg     2040

tgtgcaccat gaacgacggt ccccacagtg ccttatacac catgatgaag gaccagtatg     2100

ccaactacgt ggtccagaag atgattgacg tggcggagcc aggccagcgg aagatcgtca     2160

tgcataagat ccggccccac atcgcaactc ttcgtaagta cacctatggc aagcacattc     2220

tggccaagct ggagaagtac tacatgaaga acggtgttga cttaggggac ccaaagaaga     2280

agcgcaaagt ggatcctaaa aagaaaagaa aggtaggcgg ccgcggggga ggcggttccg     2340

gtggcggcgg aagcggaggt ggaggatcag ggccggccat gagcagccac cataccacct     2400

ttccttttga ccctgagcgg cgagtccgga gtacgctgaa gaaggtcttt gggtttgact     2460

cttttaagac gcctttacag gagagtgcga ccatggctgt agtaaaaggt aacaaggacg     2520

tctttgtgtg catgcccaca ggggcaggaa aatccctatg ctatcagctc cctgctctgt     2580

tggccaaagg catcaccatt gtagtctctc ctctcattgc tttgattcag gaccaagtgg     2640

accacttgct aaccctaaag gtacgagtaa gttccctgaa ctcgaagctc tctgcacagg     2700

aaaggaagga gctgcttgct gacctggagc gagaaaagcc ccagaccaag attctgtaca     2760

tcaccccaga gatggcagct tcatcctcct tccagcccac cctgaactcc ctggtgtccc     2820

gccacctgct gtcttacttg gtggtggatg aagctcattg tgtttcccaa tgggggcatg     2880

actttcgtcc tgactacttg cgtctgggtg ccctgcgctc ccgcctggga catgcccctt     2940

gtgtggctct gaccgccaca gccaccccac aggtccaaga ggacgtgttt gctgccctgc     3000

acctgaagaa accagttgcc atcttcaaga ctccctgctt ccgggccaac ctcttctatg     3060

atgtgcaatt caaggaactg atttctgatc cctatgggaa cctgaaggac ttctgcctta     3120

aggctcttgg acaggaggct gataaagggt tatctggctg cggcattgtg tactgcagga     3180

ctagagaggc ttgtgaacag ctggccatag agctcagctg caggggtgtg aacgccaagg     3240

cttaccatgc agggctgaag gcctctgaaa gaacgctggt gcagaacgac tggatggagg     3300

agaaggtccc tgtaattgtt gcaaccatta gttttgggat gggagtggat aaagccaatg     3360

tcaggtttgt cgcccattgg aatattgcca agtctatggc tgggtactac caggagtctg     3420

gccgggctgg cagggatggg aagccttcct ggtgccgtct ctattactcc aggaatgacc     3480

gggaccaagt cagcttcctg atcaggaagg aagtagcaaa actccaggaa aagagaggaa     3540

acaaagcatc tgataaagcc actatcatgg cctttgatgc cctggtgacc ttctgtgaag     3600

aactggggtg ccgccatgcc gccattgcca agtacttcgg ggatgcgctg cctgcctgcg     3660

ccaaaggctg cgaccactgc cagaacccca cggccgtgcg gaggcggctg gaggccttgg     3720

agcgcagcag cagctggagc aagacctgca tcgggccctc ccaggggaac ggctttgacc     3780

ccgagctgta cgagggaggc cgcaagggct acggggactt cagcaggtat gacgaaggtt     3840

ctggaggcag cggggatgaa ggcagagatg aggcccacaa gcgggagtgg aacctcttct     3900

atcagaagca gatgcagctg cgcaagggca aagaccccaa gatagaagaa tttgtacccc     3960

cagatgagaa ctgtcccctg aaagaggctt ctagcaggag gatccccagg ctgactgtga     4020

aggcacggga gcactgcctg cggcttctgg aggaggcgct gagcagcaac cgccagtcaa     4080

cacgtaccgc tgatgaagct gacctccggg ccaaggccgt ggagctggaa catgagacat     4140

tccggaacgc caaggtggcc aacctctaca aggccagcgt gctgaagaag gtggccgata     4200

tccacagagc ctccaaggat gggcagccct atgacatggg aggcagtgcc aagagctgca     4260

gtgcccaagc tgagcccccg gagcccaatg agtatgacat tccaccagcc tcccatgtgt     4320

actcgctcaa acccaagcgg gtgggagctg gtttccccaa aggctcctgc ccgttccaga     4380

cggccacgga actgatggag acgactcgga tcagggagca agccccccag cccgagcggg     4440

gaggcgagca tgagcccccg agccggccct gtggcctcct ggatgaggat gggagtgagc     4500

ccctccctgg gcccagaggg gaggtccctg gaggcagcgc tcactatggg gggccctccc     4560

ctgagaagaa ggcaaaaagt tcctctgggg gcagctccct tgccaagggc cgggctagca     4620

agaaacagca gctcctagcc acagcggccc acaaggattc tcagagcatc gcccgcttct     4680

tctgccgaag ggtggaaagc ccagctctgc tggcatcagc cccagaggca gaaggtgcct     4740

gcccctcctg tgagggggtt cagggacccc cgatggcccc agagaagtac acaggggagg     4800

aagatggagc cgggggacat tcgcctgccc ctccccagac tgaggagtgc ctcagggaga     4860

ggccaagcac ctgcccgccc agagaccagg gcacccctga agtccagccc acccctgcaa     4920

aggacacatg gaagggcaag cggcctcgat cccagcagga gaacccagag agccagcctc     4980

agaagaggcc acgcccctca gccaagccct ccgtcgtagc tgaggtcaag ggcagcgtct     5040

cggccagcga acagggcacc ttgaatccca cggctcaaga ccccttccag ctctccgctc     5100

ctggcgtctc cttgaaggag gctgcaaatg ttgtggtcaa gtgcctcacc cctttctaca     5160

aggagggcaa gtttgcttcc aaggagttgt ttaaaggctt tgcccgccac ctctcacact     5220

tgctgactca gaagacctct cctggaagga gcgtgaaaga agaggcccag aacctcatca     5280

ggcacttctt ccatggccgg gcccggtgcg agagcgaagc tgactggcat ggcctgtgtg     5340

gcccccagag aatcgattga ttaattaaga attcgaccca gctttcttgt acaaagtggt     5400

tgatatccag cacagtggcg gccgctcgag tctagagggc ccgcggttcg aaggtaagcc     5460

tatccctaac cctctcctcg gtctcgattc tacgcgtacc ggttagcaat tgttttttcg     5520

atgagtttgg acaaaccaca actagaatgc agtgaaaaaa atgctttatt tgtgaaattt     5580

gtgatgctat tgctttattt gtaaccatta taagctgcaa taaacaagtt aacaacaaca     5640

attgcattca ttttatgttt caggttcagg gggaggtgtg ggaggttttt taaagcaagt     5700

aaaacctcta caaatgtggt acttaagagg gggagaccaa agggcgagac gttaaggcct     5760

cacgtgacat gtgagcaaaa ggccagcaaa aggccaggaa ccgtaaaaag gccgcgttgc     5820

tggcgttttt ccataggctc cgcccccctg acgagcatca caaaaatcga cgctcaagtc     5880

agaggtggcg aaacccgaca ggactataaa gataccaggc gtttccccct ggaagctccc     5940

tcgtgcgctc tcctgttccg accctgccgc ttaccggata cctgtccgcc tttctccctt     6000

cgggaagcgt ggcgctttct catagctcac gctgtaggta tctcagttcg gtgtaggtcg     6060

ttcgctccaa gctgggctgt gtgcacgaac cccccgttca gcccgaccgc tgcgccttat     6120

ccggtaacta tcgtcttgag tccaacccgg taagacacga cttatcgcca ctggcagcag     6180

ccactggtaa caggattagc agagcgaggt atgtaggcgg tgctacagag ttcttgaagt     6240

ggtggcctaa ctacggctac actagaagga cagtatttgg tatctgcgct ctgctgaagc     6300

cagttacctt cggaaaaaga gttggtagct cttgatccgg caaacaaacc acgctggtag     6360

cggtggtttt tttgtttgca agcagcagat tacgcgcaga aaaaaaggat ctcaagaaga     6420

tcctttgatc ttttctacgg ggtctgacgc tcagtggaac gaaaactcac gttaagggat     6480

tttggtcatg ccgtctcaga agaactcgtc aagaaggcga tagaaggcga tgcgctgcga     6540

atcgggagcg gcgataccgt aaagcacgag gaagcggtca gcccattcgc cgccaagctc     6600

ttcagcaata tcacgggtag ccaacgctat gtcctgatag cggtccgcca cacccagccg     6660

gccacagtcg atgaatccag aaaagcggcc attttccacc atgatattcg gcaagcaggc     6720

atcgccatgg gtcacgacga gatcctcgcc gtcgggcatg ctcgccttga gcctggcgaa     6780

cagttcggct ggcgcgagcc cctgatgctc ttcgtccaga tcatcctgat cgacaagacc     6840

ggcttccatc cgagtacgtg ctcgctcgat gcgatgtttc gcttggtggt cgaatgggca     6900

ggtagccgga tcaagcgtat gcagccgccg cattgcatca gccatgatgg atactttctc     6960

ggcaggagca aggtgagatg acaggagatc ctgccccggc acttcgccca atagcagcca     7020

gtcccttccc gcttcagtga caacgtcgag cacagctgcg caaggaacgc ccgtcgtggc     7080

cagccacgat agccgcgctg cctcgtcttg cagttcattc agggcaccgg acaggtcggt     7140

cttgacaaaa agaaccgggc gcccctgcgc tgacagccgg aacacggcgg catcagagca     7200

gccgattgtc tgttgtgccc agtcatagcc gaatagcctc tccacccaag cggccggaga     7260

acctgcgtgc aatccatctt gttcaatcat aatattattg aagcatttat cagggttcgt     7320

ctcgtcccgg tctcctccca tgcatg                                          7346


<210>  62
<211>  1450
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  62

Met Ile Asp Gly Gly Gly Gly Ser Asp Pro Lys Lys Lys Arg Lys Val 
1               5                   10                  15      


Asp Pro Lys Lys Lys Arg Lys Val Asp Pro Lys Lys Lys Arg Lys Val 
            20                  25                  30          


Gly Ser Thr Gly Ser Arg Asn Asp Gly Gly Gly Gly Ser Gly Gly Gly 
        35                  40                  45              


Gly Ser Gly Gly Gly Gly Ser Gly Arg Ala Gly Ile Leu Pro Pro Lys 
    50                  55                  60                  


Lys Lys Arg Lys Val Ser Arg Gly Arg Ser Arg Leu Leu Glu Asp Phe 
65                  70                  75                  80  


Arg Asn Asn Arg Tyr Pro Asn Leu Gln Leu Arg Glu Ile Ala Gly His 
                85                  90                  95      


Ile Met Glu Phe Ser Gln Asp Gln His Gly Ser Arg Phe Ile Gln Leu 
            100                 105                 110         


Lys Leu Glu Arg Ala Thr Pro Ala Glu Arg Gln Leu Val Phe Asn Glu 
        115                 120                 125             


Ile Leu Gln Ala Ala Tyr Gln Leu Met Val Asp Val Phe Gly Asn Tyr 
    130                 135                 140                 


Val Ile Gln Lys Phe Phe Glu Phe Gly Ser Leu Glu Gln Lys Leu Ala 
145                 150                 155                 160 


Leu Ala Glu Arg Ile Arg Gly His Val Leu Ser Leu Ala Leu Gln Met 
                165                 170                 175     


Tyr Gly Ser Arg Val Ile Glu Lys Ala Leu Glu Phe Ile Pro Ser Asp 
            180                 185                 190         


Gln Gln Asn Glu Met Val Arg Glu Leu Asp Gly His Val Leu Lys Cys 
        195                 200                 205             


Val Lys Asp Gln Asn Gly Asn His Val Val Gln Lys Cys Ile Glu Cys 
    210                 215                 220                 


Val Gln Pro Gln Ser Leu Gln Phe Ile Ile Asp Ala Phe Lys Gly Gln 
225                 230                 235                 240 


Val Phe Ala Leu Ser Thr His Pro Tyr Gly Cys Arg Val Ile Gln Arg 
                245                 250                 255     


Ile Leu Glu His Cys Leu Pro Asp Gln Thr Leu Pro Ile Leu Glu Glu 
            260                 265                 270         


Leu His Gln His Thr Glu Gln Leu Val Gln Asp Gln Tyr Gly Asn Tyr 
        275                 280                 285             


Val Ile Gln His Val Leu Glu His Gly Arg Pro Glu Asp Lys Ser Lys 
    290                 295                 300                 


Ile Val Ala Glu Ile Arg Gly Asn Val Leu Val Leu Ser Gln His Lys 
305                 310                 315                 320 


Phe Ala Ser Asn Val Val Glu Lys Cys Val Thr His Ala Ser Arg Thr 
                325                 330                 335     


Glu Arg Ala Val Leu Ile Asp Glu Val Cys Thr Met Asn Asp Gly Pro 
            340                 345                 350         


His Ser Ala Leu Tyr Thr Met Met Lys Asp Gln Tyr Ala Asn Tyr Val 
        355                 360                 365             


Val Gln Lys Met Ile Asp Val Ala Glu Pro Gly Gln Arg Lys Ile Val 
    370                 375                 380                 


Met His Lys Ile Arg Pro His Ile Ala Thr Leu Arg Lys Tyr Thr Tyr 
385                 390                 395                 400 


Gly Lys His Ile Leu Ala Lys Leu Glu Lys Tyr Tyr Met Lys Asn Gly 
                405                 410                 415     


Val Asp Leu Gly Asp Pro Lys Lys Lys Arg Lys Val Asp Pro Lys Lys 
            420                 425                 430         


Lys Arg Lys Val Gly Gly Arg Gly Gly Gly Gly Ser Gly Gly Gly Gly 
        435                 440                 445             


Ser Gly Gly Gly Gly Ser Gly Pro Ala Met Ser Ser His His Thr Thr 
    450                 455                 460                 


Phe Pro Phe Asp Pro Glu Arg Arg Val Arg Ser Thr Leu Lys Lys Val 
465                 470                 475                 480 


Phe Gly Phe Asp Ser Phe Lys Thr Pro Leu Gln Glu Ser Ala Thr Met 
                485                 490                 495     


Ala Val Val Lys Gly Asn Lys Asp Val Phe Val Cys Met Pro Thr Gly 
            500                 505                 510         


Ala Gly Lys Ser Leu Cys Tyr Gln Leu Pro Ala Leu Leu Ala Lys Gly 
        515                 520                 525             


Ile Thr Ile Val Val Ser Pro Leu Ile Ala Leu Ile Gln Asp Gln Val 
    530                 535                 540                 


Asp His Leu Leu Thr Leu Lys Val Arg Val Ser Ser Leu Asn Ser Lys 
545                 550                 555                 560 


Leu Ser Ala Gln Glu Arg Lys Glu Leu Leu Ala Asp Leu Glu Arg Glu 
                565                 570                 575     


Lys Pro Gln Thr Lys Ile Leu Tyr Ile Thr Pro Glu Met Ala Ala Ser 
            580                 585                 590         


Ser Ser Phe Gln Pro Thr Leu Asn Ser Leu Val Ser Arg His Leu Leu 
        595                 600                 605             


Ser Tyr Leu Val Val Asp Glu Ala His Cys Val Ser Gln Trp Gly His 
    610                 615                 620                 


Asp Phe Arg Pro Asp Tyr Leu Arg Leu Gly Ala Leu Arg Ser Arg Leu 
625                 630                 635                 640 


Gly His Ala Pro Cys Val Ala Leu Thr Ala Thr Ala Thr Pro Gln Val 
                645                 650                 655     


Gln Glu Asp Val Phe Ala Ala Leu His Leu Lys Lys Pro Val Ala Ile 
            660                 665                 670         


Phe Lys Thr Pro Cys Phe Arg Ala Asn Leu Phe Tyr Asp Val Gln Phe 
        675                 680                 685             


Lys Glu Leu Ile Ser Asp Pro Tyr Gly Asn Leu Lys Asp Phe Cys Leu 
    690                 695                 700                 


Lys Ala Leu Gly Gln Glu Ala Asp Lys Gly Leu Ser Gly Cys Gly Ile 
705                 710                 715                 720 


Val Tyr Cys Arg Thr Arg Glu Ala Cys Glu Gln Leu Ala Ile Glu Leu 
                725                 730                 735     


Ser Cys Arg Gly Val Asn Ala Lys Ala Tyr His Ala Gly Leu Lys Ala 
            740                 745                 750         


Ser Glu Arg Thr Leu Val Gln Asn Asp Trp Met Glu Glu Lys Val Pro 
        755                 760                 765             


Val Ile Val Ala Thr Ile Ser Phe Gly Met Gly Val Asp Lys Ala Asn 
    770                 775                 780                 


Val Arg Phe Val Ala His Trp Asn Ile Ala Lys Ser Met Ala Gly Tyr 
785                 790                 795                 800 


Tyr Gln Glu Ser Gly Arg Ala Gly Arg Asp Gly Lys Pro Ser Trp Cys 
                805                 810                 815     


Arg Leu Tyr Tyr Ser Arg Asn Asp Arg Asp Gln Val Ser Phe Leu Ile 
            820                 825                 830         


Arg Lys Glu Val Ala Lys Leu Gln Glu Lys Arg Gly Asn Lys Ala Ser 
        835                 840                 845             


Asp Lys Ala Thr Ile Met Ala Phe Asp Ala Leu Val Thr Phe Cys Glu 
    850                 855                 860                 


Glu Leu Gly Cys Arg His Ala Ala Ile Ala Lys Tyr Phe Gly Asp Ala 
865                 870                 875                 880 


Leu Pro Ala Cys Ala Lys Gly Cys Asp His Cys Gln Asn Pro Thr Ala 
                885                 890                 895     


Val Arg Arg Arg Leu Glu Ala Leu Glu Arg Ser Ser Ser Trp Ser Lys 
            900                 905                 910         


Thr Cys Ile Gly Pro Ser Gln Gly Asn Gly Phe Asp Pro Glu Leu Tyr 
        915                 920                 925             


Glu Gly Gly Arg Lys Gly Tyr Gly Asp Phe Ser Arg Tyr Asp Glu Gly 
    930                 935                 940                 


Ser Gly Gly Ser Gly Asp Glu Gly Arg Asp Glu Ala His Lys Arg Glu 
945                 950                 955                 960 


Trp Asn Leu Phe Tyr Gln Lys Gln Met Gln Leu Arg Lys Gly Lys Asp 
                965                 970                 975     


Pro Lys Ile Glu Glu Phe Val Pro Pro Asp Glu Asn Cys Pro Leu Lys 
            980                 985                 990         


Glu Ala Ser Ser Arg Arg Ile Pro  Arg Leu Thr Val Lys  Ala Arg Glu 
        995                 1000                 1005             


His Cys  Leu Arg Leu Leu Glu  Glu Ala Leu Ser Ser  Asn Arg Gln 
    1010                 1015                 1020             


Ser Thr  Arg Thr Ala Asp Glu  Ala Asp Leu Arg Ala  Lys Ala Val 
    1025                 1030                 1035             


Glu Leu  Glu His Glu Thr Phe  Arg Asn Ala Lys Val  Ala Asn Leu 
    1040                 1045                 1050             


Tyr Lys  Ala Ser Val Leu Lys  Lys Val Ala Asp Ile  His Arg Ala 
    1055                 1060                 1065             


Ser Lys  Asp Gly Gln Pro Tyr  Asp Met Gly Gly Ser  Ala Lys Ser 
    1070                 1075                 1080             


Cys Ser  Ala Gln Ala Glu Pro  Pro Glu Pro Asn Glu  Tyr Asp Ile 
    1085                 1090                 1095             


Pro Pro  Ala Ser His Val Tyr  Ser Leu Lys Pro Lys  Arg Val Gly 
    1100                 1105                 1110             


Ala Gly  Phe Pro Lys Gly Ser  Cys Pro Phe Gln Thr  Ala Thr Glu 
    1115                 1120                 1125             


Leu Met  Glu Thr Thr Arg Ile  Arg Glu Gln Ala Pro  Gln Pro Glu 
    1130                 1135                 1140             


Arg Gly  Gly Glu His Glu Pro  Pro Ser Arg Pro Cys  Gly Leu Leu 
    1145                 1150                 1155             


Asp Glu  Asp Gly Ser Glu Pro  Leu Pro Gly Pro Arg  Gly Glu Val 
    1160                 1165                 1170             


Pro Gly  Gly Ser Ala His Tyr  Gly Gly Pro Ser Pro  Glu Lys Lys 
    1175                 1180                 1185             


Ala Lys  Ser Ser Ser Gly Gly  Ser Ser Leu Ala Lys  Gly Arg Ala 
    1190                 1195                 1200             


Ser Lys  Lys Gln Gln Leu Leu  Ala Thr Ala Ala His  Lys Asp Ser 
    1205                 1210                 1215             


Gln Ser  Ile Ala Arg Phe Phe  Cys Arg Arg Val Glu  Ser Pro Ala 
    1220                 1225                 1230             


Leu Leu  Ala Ser Ala Pro Glu  Ala Glu Gly Ala Cys  Pro Ser Cys 
    1235                 1240                 1245             


Glu Gly  Val Gln Gly Pro Pro  Met Ala Pro Glu Lys  Tyr Thr Gly 
    1250                 1255                 1260             


Glu Glu  Asp Gly Ala Gly Gly  His Ser Pro Ala Pro  Pro Gln Thr 
    1265                 1270                 1275             


Glu Glu  Cys Leu Arg Glu Arg  Pro Ser Thr Cys Pro  Pro Arg Asp 
    1280                 1285                 1290             


Gln Gly  Thr Pro Glu Val Gln  Pro Thr Pro Ala Lys  Asp Thr Trp 
    1295                 1300                 1305             


Lys Gly  Lys Arg Pro Arg Ser  Gln Gln Glu Asn Pro  Glu Ser Gln 
    1310                 1315                 1320             


Pro Gln  Lys Arg Pro Arg Pro  Ser Ala Lys Pro Ser  Val Val Ala 
    1325                 1330                 1335             


Glu Val  Lys Gly Ser Val Ser  Ala Ser Glu Gln Gly  Thr Leu Asn 
    1340                 1345                 1350             


Pro Thr  Ala Gln Asp Pro Phe  Gln Leu Ser Ala Pro  Gly Val Ser 
    1355                 1360                 1365             


Leu Lys  Glu Ala Ala Asn Val  Val Val Lys Cys Leu  Thr Pro Phe 
    1370                 1375                 1380             


Tyr Lys  Glu Gly Lys Phe Ala  Ser Lys Glu Leu Phe  Lys Gly Phe 
    1385                 1390                 1395             


Ala Arg  His Leu Ser His Leu  Leu Thr Gln Lys Thr  Ser Pro Gly 
    1400                 1405                 1410             


Arg Ser  Val Lys Glu Glu Ala  Gln Asn Leu Ile Arg  His Phe Phe 
    1415                 1420                 1425             


His Gly  Arg Ala Arg Cys Glu  Ser Glu Ala Asp Trp  His Gly Leu 
    1430                 1435                 1440             


Cys Gly  Pro Gln Arg Ile Asp  
    1445                 1450 


<210>  63
<211>  5591
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide

<400>  63
tcaatattgg ccattagcca tattattcat tggttatata gcataaatca atattggcta       60

ttggccattg catacgttgt atctatatca taatatgtac atttatattg gctcatgtcc      120

aatatgaccg ccatgttggc attgattatt gactagttat taatagtaat caattacggg      180

gtcattagtt catagcccat atatggagtt ccgcgttaca taacttacgg taaatggccc      240

gcctggctga ccgcccaacg acccccgccc attgacgtca ataatgacgt atgttcccat      300

agtaacgcca atagggactt tccattgacg tcaatgggtg gagtatttac ggtaaactgc      360

ccacttggca gtacatcaag tgtatcatat gccaagtccg ccccctattg acgtcaatga      420

cggtaaatgg cccgcctggc attatgccca gtacatgacc ttacgggact ttcctacttg      480

gcagtacatc tacgtattag tcatcgctat taccatggtg atgcggtttt ggcagtacac      540

caatgggcgt ggatagcggt ttgactcacg gggatttcca agtctccacc ccattgacgt      600

caatgggagt ttgttttggc accaaaatca acgggacttt ccaaaatgtc gtaataaccc      660

cgccccgttg acgcaaatgg gcggtaggcg tgtacggtgg gaggtctata taagcagagg      720

tcgtttagtg aaccgtcaga tcactagtag ctttattgcg gtagtttatc acagttaaat      780

tgctaacgca gtcagtgctc gactgatcac aggtaagtat caaggttaca agacaggttt      840

aaggaggcca atagaaactg ggcttgtcga gacagagaag attcttgcgt ttctgatagg      900

cacctattgg tcttactgac atccactttg cctttctctc cacagggaaa aaacaattga      960

caagtttgta caaaaaagca ggctccgaat tcaccggtgc cgccaccatg gggccggcca     1020

tgggaattca aggcctggcc aaactaattg ctgatgtggc ccccagtgcc atccgggaga     1080

atgacatcaa gagctacttt ggccgtaagg tggccattga tgcctctatg agcatttatc     1140

agttcctgat tgctgttcgc cagggtgggg atgtgctgca gaatgaggag ggtgagacca     1200

ccagccacct gatgggcatg ttctaccgca ccattcgcat gatggagaac ggcatcaagc     1260

ccgtgtatgt ctttgatggc aagccgccac agctcaagtc aggcgagctg gccaaacgca     1320

gtgagcggcg ggctgaggca gagaagcagc tgcagcaggc tcaggctgct ggggccgagc     1380

aggaggtgga aaaattcact aagcggctgg tgaaggtcac taagcagcac aatgatgagt     1440

gcaaacatct gctgagcctc atgggcatcc cttatcttga tgcacccagt gaggcagagg     1500

ccagctgtgc tgccctggtg aaggctggca aagtctatgc tgcggctacc gaggacatgg     1560

actgcctcac cttcggcagc cctgtgctaa tgcgacacct gactgccagt gaagccaaaa     1620

agctgccaat ccaggaattc cacctgagcc ggattctgca ggagctgggc ctgaaccagg     1680

aacagtttgt ggatctgtgc atcctgctag gcagtgacta ctgtgagagt atccggggta     1740

ttgggcccaa gcgggctgtg gacctcatcc agaagcacaa gagcatcgag gagatcgtgc     1800

ggcgacttga ccccaacaag taccctgtgc cagaaaattg gctccacaag gaggctcacc     1860

agctcttctt ggaacctgag gtgctggacc cagagtctgt ggagctgaag tggagcgagc     1920

caaatgaaga agagctgatc aagttcatgt gtggtgaaaa gcagttctct gaggagcgaa     1980

tccgcagtgg ggtcaagagg ctgagtaaga gccgccaagg cagcacccag ggccgcctgg     2040

atgatttctt caaggtgacc ggctcactct cttcagctaa gcgcaaggag ccagaaccca     2100

agggatccac taagaagaag gcaaagactg gggcagcagg gaagtttaaa aggggaaaaa     2160

acgttatcga tggcggaggc ggatctgatc caaaaaagaa gagaaaggta gatccaaaaa     2220

agaagagaaa ggtagatcca aaaaagaaga gaaaggtagg atctaccgga tctagaaacg     2280

atggtggtgg tggaagcggg ggtgggggca gcggtggagg gggaagcggg cgcgccggga     2340

tcctcccccc caagaaaaag aggaaggtat ctagaggccg cagccgcctt ttggaagatt     2400

ttcgaaacaa ccggtacccc aatttacaac tgcgggagat tgctggacat ataatggaat     2460

tttcccaaga ccagcatggg tccagattca ttcagctgaa actggagcgt gccacaccag     2520

ctgagcgcca gcttgtcttc aatgaaatcc tccaggctgc ctaccaactc atggtggatg     2580

tgtttggtaa ttacgtcatt cagaagttct ttgaatttgg cagtcttgaa cagaagctgg     2640

ctttggcaga acggattcga ggccacgtcc tgtcattggc actacagatg tatggcagcc     2700

gtgttatcga gaaagctctt gagtttattc cttcagacca gcagaatgag atggttcggg     2760

aactagatgg ccatgtcttg aagtgtgtga aagatcagaa tggcaatcac gtggttcaga     2820

aatgcattga atgtgtacag ccccagtctt tgcaatttat catcgacgcg tttaagggac     2880

aggtatttgc cttatccaca catccttatg gctgccgagt gattcagaga atcctggagc     2940

actgtctccc tgaccagaca ctccctattt tagaggagct tcaccagcac acagagcagc     3000

tggtacagga tcaatatgga aattatgtaa tccaacatgt actggagcac ggtcgtcctg     3060

aggataaaag caaaattgta gcagaaatcc gaggcaatgt acttgtattg agtcagcaca     3120

aatttgcaag caatgttgtg gagaagtgtg ttactcacgc ctcacgtacg gagcgcgctg     3180

tgctcatcga cgaggtgtgc accatgaacg acggtcccca cagtgcctta tacaccatga     3240

tgaaggacca gtatgccaac tacgtggtcc agaagatgat tgacgtggcg gagccaggcc     3300

agcggaagat cgtcatgcat aagatccggc cccacatcgc aactcttcgt aagtacacct     3360

atggcaagca cattctggcc aagctggaga agtactacat gaagaacggt gttgacttag     3420

gggacccaaa gaagaagcgc aaagtggatc ctaaaaagaa aagaaaggta ggcggccgcg     3480

ggggaggcgg ttccggtggc ggcggaagcg gaggtggagg atcagggccg gccatggact     3540

acaaggatca cgacggtgac tataaggatc atgacatcga ctataaggac gatgacgata     3600

agtgattaat taagaattcg acccagcttt cttgtacaaa gtggttgata tccagcacag     3660

tggcggccgc tcgagtctag agggcccgcg gttcgaaggt aagcctatcc ctaaccctct     3720

cctcggtctc gattctacgc gtaccggtta gcaattgttt tttcgatgag tttggacaaa     3780

ccacaactag aatgcagtga aaaaaatgct ttatttgtga aatttgtgat gctattgctt     3840

tatttgtaac cattataagc tgcaataaac aagttaacaa caacaattgc attcatttta     3900

tgtttcaggt tcagggggag gtgtgggagg ttttttaaag caagtaaaac ctctacaaat     3960

gtggtactta agagggggag accaaagggc gagacgttaa ggcctcacgt gacatgtgag     4020

caaaaggcca gcaaaaggcc aggaaccgta aaaaggccgc gttgctggcg tttttccata     4080

ggctccgccc ccctgacgag catcacaaaa atcgacgctc aagtcagagg tggcgaaacc     4140

cgacaggact ataaagatac caggcgtttc cccctggaag ctccctcgtg cgctctcctg     4200

ttccgaccct gccgcttacc ggatacctgt ccgcctttct cccttcggga agcgtggcgc     4260

tttctcatag ctcacgctgt aggtatctca gttcggtgta ggtcgttcgc tccaagctgg     4320

gctgtgtgca cgaacccccc gttcagcccg accgctgcgc cttatccggt aactatcgtc     4380

ttgagtccaa cccggtaaga cacgacttat cgccactggc agcagccact ggtaacagga     4440

ttagcagagc gaggtatgta ggcggtgcta cagagttctt gaagtggtgg cctaactacg     4500

gctacactag aaggacagta tttggtatct gcgctctgct gaagccagtt accttcggaa     4560

aaagagttgg tagctcttga tccggcaaac aaaccacgct ggtagcggtg gtttttttgt     4620

ttgcaagcag cagattacgc gcagaaaaaa aggatctcaa gaagatcctt tgatcttttc     4680

tacggggtct gacgctcagt ggaacgaaaa ctcacgttaa gggattttgg tcatgccgtc     4740

tcagaagaac tcgtcaagaa ggcgatagaa ggcgatgcgc tgcgaatcgg gagcggcgat     4800

accgtaaagc acgaggaagc ggtcagccca ttcgccgcca agctcttcag caatatcacg     4860

ggtagccaac gctatgtcct gatagcggtc cgccacaccc agccggccac agtcgatgaa     4920

tccagaaaag cggccatttt ccaccatgat attcggcaag caggcatcgc catgggtcac     4980

gacgagatcc tcgccgtcgg gcatgctcgc cttgagcctg gcgaacagtt cggctggcgc     5040

gagcccctga tgctcttcgt ccagatcatc ctgatcgaca agaccggctt ccatccgagt     5100

acgtgctcgc tcgatgcgat gtttcgcttg gtggtcgaat gggcaggtag ccggatcaag     5160

cgtatgcagc cgccgcattg catcagccat gatggatact ttctcggcag gagcaaggtg     5220

agatgacagg agatcctgcc ccggcacttc gcccaatagc agccagtccc ttcccgcttc     5280

agtgacaacg tcgagcacag ctgcgcaagg aacgcccgtc gtggccagcc acgatagccg     5340

cgctgcctcg tcttgcagtt cattcagggc accggacagg tcggtcttga caaaaagaac     5400

cgggcgcccc tgcgctgaca gccggaacac ggcggcatca gagcagccga ttgtctgttg     5460

tgcccagtca tagccgaata gcctctccac ccaagcggcc ggagaacctg cgtgcaatcc     5520

atcttgttca atcataatat tattgaagca tttatcaggg ttcgtctcgt cccggtctcc     5580

tcccatgcat g                                                          5591


<210>  64
<211>  865
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  64

Met Gly Pro Ala Met Gly Ile Gln Gly Leu Ala Lys Leu Ile Ala Asp 
1               5                   10                  15      


Val Ala Pro Ser Ala Ile Arg Glu Asn Asp Ile Lys Ser Tyr Phe Gly 
            20                  25                  30          


Arg Lys Val Ala Ile Asp Ala Ser Met Ser Ile Tyr Gln Phe Leu Ile 
        35                  40                  45              


Ala Val Arg Gln Gly Gly Asp Val Leu Gln Asn Glu Glu Gly Glu Thr 
    50                  55                  60                  


Thr Ser His Leu Met Gly Met Phe Tyr Arg Thr Ile Arg Met Met Glu 
65                  70                  75                  80  


Asn Gly Ile Lys Pro Val Tyr Val Phe Asp Gly Lys Pro Pro Gln Leu 
                85                  90                  95      


Lys Ser Gly Glu Leu Ala Lys Arg Ser Glu Arg Arg Ala Glu Ala Glu 
            100                 105                 110         


Lys Gln Leu Gln Gln Ala Gln Ala Ala Gly Ala Glu Gln Glu Val Glu 
        115                 120                 125             


Lys Phe Thr Lys Arg Leu Val Lys Val Thr Lys Gln His Asn Asp Glu 
    130                 135                 140                 


Cys Lys His Leu Leu Ser Leu Met Gly Ile Pro Tyr Leu Asp Ala Pro 
145                 150                 155                 160 


Ser Glu Ala Glu Ala Ser Cys Ala Ala Leu Val Lys Ala Gly Lys Val 
                165                 170                 175     


Tyr Ala Ala Ala Thr Glu Asp Met Asp Cys Leu Thr Phe Gly Ser Pro 
            180                 185                 190         


Val Leu Met Arg His Leu Thr Ala Ser Glu Ala Lys Lys Leu Pro Ile 
        195                 200                 205             


Gln Glu Phe His Leu Ser Arg Ile Leu Gln Glu Leu Gly Leu Asn Gln 
    210                 215                 220                 


Glu Gln Phe Val Asp Leu Cys Ile Leu Leu Gly Ser Asp Tyr Cys Glu 
225                 230                 235                 240 


Ser Ile Arg Gly Ile Gly Pro Lys Arg Ala Val Asp Leu Ile Gln Lys 
                245                 250                 255     


His Lys Ser Ile Glu Glu Ile Val Arg Arg Leu Asp Pro Asn Lys Tyr 
            260                 265                 270         


Pro Val Pro Glu Asn Trp Leu His Lys Glu Ala His Gln Leu Phe Leu 
        275                 280                 285             


Glu Pro Glu Val Leu Asp Pro Glu Ser Val Glu Leu Lys Trp Ser Glu 
    290                 295                 300                 


Pro Asn Glu Glu Glu Leu Ile Lys Phe Met Cys Gly Glu Lys Gln Phe 
305                 310                 315                 320 


Ser Glu Glu Arg Ile Arg Ser Gly Val Lys Arg Leu Ser Lys Ser Arg 
                325                 330                 335     


Gln Gly Ser Thr Gln Gly Arg Leu Asp Asp Phe Phe Lys Val Thr Gly 
            340                 345                 350         


Ser Leu Ser Ser Ala Lys Arg Lys Glu Pro Glu Pro Lys Gly Ser Thr 
        355                 360                 365             


Lys Lys Lys Ala Lys Thr Gly Ala Ala Gly Lys Phe Lys Arg Gly Lys 
    370                 375                 380                 


Asn Val Ile Asp Gly Gly Gly Gly Ser Asp Pro Lys Lys Lys Arg Lys 
385                 390                 395                 400 


Val Asp Pro Lys Lys Lys Arg Lys Val Asp Pro Lys Lys Lys Arg Lys 
                405                 410                 415     


Val Gly Ser Thr Gly Ser Arg Asn Asp Gly Gly Gly Gly Ser Gly Gly 
            420                 425                 430         


Gly Gly Ser Gly Gly Gly Gly Ser Gly Arg Ala Gly Ile Leu Pro Pro 
        435                 440                 445             


Lys Lys Lys Arg Lys Val Ser Arg Gly Arg Ser Arg Leu Leu Glu Asp 
    450                 455                 460                 


Phe Arg Asn Asn Arg Tyr Pro Asn Leu Gln Leu Arg Glu Ile Ala Gly 
465                 470                 475                 480 


His Ile Met Glu Phe Ser Gln Asp Gln His Gly Ser Arg Phe Ile Gln 
                485                 490                 495     


Leu Lys Leu Glu Arg Ala Thr Pro Ala Glu Arg Gln Leu Val Phe Asn 
            500                 505                 510         


Glu Ile Leu Gln Ala Ala Tyr Gln Leu Met Val Asp Val Phe Gly Asn 
        515                 520                 525             


Tyr Val Ile Gln Lys Phe Phe Glu Phe Gly Ser Leu Glu Gln Lys Leu 
    530                 535                 540                 


Ala Leu Ala Glu Arg Ile Arg Gly His Val Leu Ser Leu Ala Leu Gln 
545                 550                 555                 560 


Met Tyr Gly Ser Arg Val Ile Glu Lys Ala Leu Glu Phe Ile Pro Ser 
                565                 570                 575     


Asp Gln Gln Asn Glu Met Val Arg Glu Leu Asp Gly His Val Leu Lys 
            580                 585                 590         


Cys Val Lys Asp Gln Asn Gly Asn His Val Val Gln Lys Cys Ile Glu 
        595                 600                 605             


Cys Val Gln Pro Gln Ser Leu Gln Phe Ile Ile Asp Ala Phe Lys Gly 
    610                 615                 620                 


Gln Val Phe Ala Leu Ser Thr His Pro Tyr Gly Cys Arg Val Ile Gln 
625                 630                 635                 640 


Arg Ile Leu Glu His Cys Leu Pro Asp Gln Thr Leu Pro Ile Leu Glu 
                645                 650                 655     


Glu Leu His Gln His Thr Glu Gln Leu Val Gln Asp Gln Tyr Gly Asn 
            660                 665                 670         


Tyr Val Ile Gln His Val Leu Glu His Gly Arg Pro Glu Asp Lys Ser 
        675                 680                 685             


Lys Ile Val Ala Glu Ile Arg Gly Asn Val Leu Val Leu Ser Gln His 
    690                 695                 700                 


Lys Phe Ala Ser Asn Val Val Glu Lys Cys Val Thr His Ala Ser Arg 
705                 710                 715                 720 


Thr Glu Arg Ala Val Leu Ile Asp Glu Val Cys Thr Met Asn Asp Gly 
                725                 730                 735     


Pro His Ser Ala Leu Tyr Thr Met Met Lys Asp Gln Tyr Ala Asn Tyr 
            740                 745                 750         


Val Val Gln Lys Met Ile Asp Val Ala Glu Pro Gly Gln Arg Lys Ile 
        755                 760                 765             


Val Met His Lys Ile Arg Pro His Ile Ala Thr Leu Arg Lys Tyr Thr 
    770                 775                 780                 


Tyr Gly Lys His Ile Leu Ala Lys Leu Glu Lys Tyr Tyr Met Lys Asn 
785                 790                 795                 800 


Gly Val Asp Leu Gly Asp Pro Lys Lys Lys Arg Lys Val Asp Pro Lys 
                805                 810                 815     


Lys Lys Arg Lys Val Gly Gly Arg Gly Gly Gly Gly Ser Gly Gly Gly 
            820                 825                 830         


Gly Ser Gly Gly Gly Gly Ser Gly Pro Ala Met Asp Tyr Lys Asp His 
        835                 840                 845             


Asp Gly Asp Tyr Lys Asp His Asp Ile Asp Tyr Lys Asp Asp Asp Asp 
    850                 855                 860                 


Lys 
865 


<210>  65
<211>  5579
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide

<400>  65
tcaatattgg ccattagcca tattattcat tggttatata gcataaatca atattggcta       60

ttggccattg catacgttgt atctatatca taatatgtac atttatattg gctcatgtcc      120

aatatgaccg ccatgttggc attgattatt gactagttat taatagtaat caattacggg      180

gtcattagtt catagcccat atatggagtt ccgcgttaca taacttacgg taaatggccc      240

gcctggctga ccgcccaacg acccccgccc attgacgtca ataatgacgt atgttcccat      300

agtaacgcca atagggactt tccattgacg tcaatgggtg gagtatttac ggtaaactgc      360

ccacttggca gtacatcaag tgtatcatat gccaagtccg ccccctattg acgtcaatga      420

cggtaaatgg cccgcctggc attatgccca gtacatgacc ttacgggact ttcctacttg      480

gcagtacatc tacgtattag tcatcgctat taccatggtg atgcggtttt ggcagtacac      540

caatgggcgt ggatagcggt ttgactcacg gggatttcca agtctccacc ccattgacgt      600

caatgggagt ttgttttggc accaaaatca acgggacttt ccaaaatgtc gtaataaccc      660

cgccccgttg acgcaaatgg gcggtaggcg tgtacggtgg gaggtctata taagcagagg      720

tcgtttagtg aaccgtcaga tcactagtag ctttattgcg gtagtttatc acagttaaat      780

tgctaacgca gtcagtgctc gactgatcac aggtaagtat caaggttaca agacaggttt      840

aaggaggcca atagaaactg ggcttgtcga gacagagaag attcttgcgt ttctgatagg      900

cacctattgg tcttactgac atccactttg cctttctctc cacagggaaa aaacaattga      960

caagtttgta caaaaaagca ggctccgaat tcaccggtgc cgccaccatg gactacaagg     1020

atcacgacgg tgactataag gatcatgaca tcgactataa ggacgatgac gataagatcg     1080

atggcggagg cggatctgat ccaaaaaaga agagaaaggt agatccaaaa aagaagagaa     1140

aggtagatcc aaaaaagaag agaaaggtag gatctaccgg atctagaaac gatggtggtg     1200

gtggaagcgg gggtgggggc agcggtggag ggggaagcgg gcgcgccggg atcctccccc     1260

ccaagaaaaa gaggaaggta tctagaggcc gcagccgcct tttggaagat tttcgaaaca     1320

accggtaccc caatttacaa ctgcgggaga ttgctggaca tataatggaa ttttcccaag     1380

accagcatgg gtccagattc attcagctga aactggagcg tgccacacca gctgagcgcc     1440

agcttgtctt caatgaaatc ctccaggctg cctaccaact catggtggat gtgtttggta     1500

attacgtcat tcagaagttc tttgaatttg gcagtcttga acagaagctg gctttggcag     1560

aacggattcg aggccacgtc ctgtcattgg cactacagat gtatggcagc cgtgttatcg     1620

agaaagctct tgagtttatt ccttcagacc agcagaatga gatggttcgg gaactagatg     1680

gccatgtctt gaagtgtgtg aaagatcaga atggcaatca cgtggttcag aaatgcattg     1740

aatgtgtaca gccccagtct ttgcaattta tcatcgacgc gtttaaggga caggtatttg     1800

ccttatccac acatccttat ggctgccgag tgattcagag aatcctggag cactgtctcc     1860

ctgaccagac actccctatt ttagaggagc ttcaccagca cacagagcag ctggtacagg     1920

atcaatatgg aaattatgta atccaacatg tactggagca cggtcgtcct gaggataaaa     1980

gcaaaattgt agcagaaatc cgaggcaatg tacttgtatt gagtcagcac aaatttgcaa     2040

gcaatgttgt ggagaagtgt gttactcacg cctcacgtac ggagcgcgct gtgctcatcg     2100

acgaggtgtg caccatgaac gacggtcccc acagtgcctt atacaccatg atgaaggacc     2160

agtatgccaa ctacgtggtc cagaagatga ttgacgtggc ggagccaggc cagcggaaga     2220

tcgtcatgca taagatccgg ccccacatcg caactcttcg taagtacacc tatggcaagc     2280

acattctggc caagctggag aagtactaca tgaagaacgg tgttgactta ggggacccaa     2340

agaagaagcg caaagtggat cctaaaaaga aaagaaaggt aggcggccgc gggggaggcg     2400

gttccggtgg cggcggaagc ggaggtggag gatcagggcc ggccatggga attcaaggcc     2460

tggccaaact aattgctgat gtggccccca gtgccatccg ggagaatgac atcaagagct     2520

actttggccg taaggtggcc attgatgcct ctatgagcat ttatcagttc ctgattgctg     2580

ttcgccaggg tggggatgtg ctgcagaatg aggagggtga gaccaccagc cacctgatgg     2640

gcatgttcta ccgcaccatt cgcatgatgg agaacggcat caagcccgtg tatgtctttg     2700

atggcaagcc gccacagctc aagtcaggcg agctggccaa acgcagtgag cggcgggctg     2760

aggcagagaa gcagctgcag caggctcagg ctgctggggc cgagcaggag gtggaaaaat     2820

tcactaagcg gctggtgaag gtcactaagc agcacaatga tgagtgcaaa catctgctga     2880

gcctcatggg catcccttat cttgatgcac ccagtgaggc agaggccagc tgtgctgccc     2940

tggtgaaggc tggcaaagtc tatgctgcgg ctaccgagga catggactgc ctcaccttcg     3000

gcagccctgt gctaatgcga cacctgactg ccagtgaagc caaaaagctg ccaatccagg     3060

aattccacct gagccggatt ctgcaggagc tgggcctgaa ccaggaacag tttgtggatc     3120

tgtgcatcct gctaggcagt gactactgtg agagtatccg gggtattggg cccaagcggg     3180

ctgtggacct catccagaag cacaagagca tcgaggagat cgtgcggcga cttgacccca     3240

acaagtaccc tgtgccagaa aattggctcc acaaggaggc tcaccagctc ttcttggaac     3300

ctgaggtgct ggacccagag tctgtggagc tgaagtggag cgagccaaat gaagaagagc     3360

tgatcaagtt catgtgtggt gaaaagcagt tctctgagga gcgaatccgc agtggggtca     3420

agaggctgag taagagccgc caaggcagca cccagggccg cctggatgat ttcttcaagg     3480

tgaccggctc actctcttca gctaagcgca aggagccaga acccaaggga tccactaaga     3540

agaaggcaaa gactggggca gcagggaagt ttaaaagggg aaaaaacgtt tgattaatta     3600

agaattcgac ccagctttct tgtacaaagt ggttgatatc cagcacagtg gcggccgctc     3660

gagtctagag ggcccgcggt tcgaaggtaa gcctatccct aaccctctcc tcggtctcga     3720

ttctacgcgt accggttagc aattgttttt tcgatgagtt tggacaaacc acaactagaa     3780

tgcagtgaaa aaaatgcttt atttgtgaaa tttgtgatgc tattgcttta tttgtaacca     3840

ttataagctg caataaacaa gttaacaaca acaattgcat tcattttatg tttcaggttc     3900

agggggaggt gtgggaggtt ttttaaagca agtaaaacct ctacaaatgt ggtacttaag     3960

agggggagac caaagggcga gacgttaagg cctcacgtga catgtgagca aaaggccagc     4020

aaaaggccag gaaccgtaaa aaggccgcgt tgctggcgtt tttccatagg ctccgccccc     4080

ctgacgagca tcacaaaaat cgacgctcaa gtcagaggtg gcgaaacccg acaggactat     4140

aaagatacca ggcgtttccc cctggaagct ccctcgtgcg ctctcctgtt ccgaccctgc     4200

cgcttaccgg atacctgtcc gcctttctcc cttcgggaag cgtggcgctt tctcatagct     4260

cacgctgtag gtatctcagt tcggtgtagg tcgttcgctc caagctgggc tgtgtgcacg     4320

aaccccccgt tcagcccgac cgctgcgcct tatccggtaa ctatcgtctt gagtccaacc     4380

cggtaagaca cgacttatcg ccactggcag cagccactgg taacaggatt agcagagcga     4440

ggtatgtagg cggtgctaca gagttcttga agtggtggcc taactacggc tacactagaa     4500

ggacagtatt tggtatctgc gctctgctga agccagttac cttcggaaaa agagttggta     4560

gctcttgatc cggcaaacaa accacgctgg tagcggtggt ttttttgttt gcaagcagca     4620

gattacgcgc agaaaaaaag gatctcaaga agatcctttg atcttttcta cggggtctga     4680

cgctcagtgg aacgaaaact cacgttaagg gattttggtc atgccgtctc agaagaactc     4740

gtcaagaagg cgatagaagg cgatgcgctg cgaatcggga gcggcgatac cgtaaagcac     4800

gaggaagcgg tcagcccatt cgccgccaag ctcttcagca atatcacggg tagccaacgc     4860

tatgtcctga tagcggtccg ccacacccag ccggccacag tcgatgaatc cagaaaagcg     4920

gccattttcc accatgatat tcggcaagca ggcatcgcca tgggtcacga cgagatcctc     4980

gccgtcgggc atgctcgcct tgagcctggc gaacagttcg gctggcgcga gcccctgatg     5040

ctcttcgtcc agatcatcct gatcgacaag accggcttcc atccgagtac gtgctcgctc     5100

gatgcgatgt ttcgcttggt ggtcgaatgg gcaggtagcc ggatcaagcg tatgcagccg     5160

ccgcattgca tcagccatga tggatacttt ctcggcagga gcaaggtgag atgacaggag     5220

atcctgcccc ggcacttcgc ccaatagcag ccagtccctt cccgcttcag tgacaacgtc     5280

gagcacagct gcgcaaggaa cgcccgtcgt ggccagccac gatagccgcg ctgcctcgtc     5340

ttgcagttca ttcagggcac cggacaggtc ggtcttgaca aaaagaaccg ggcgcccctg     5400

cgctgacagc cggaacacgg cggcatcaga gcagccgatt gtctgttgtg cccagtcata     5460

gccgaatagc ctctccaccc aagcggccgg agaacctgcg tgcaatccat cttgttcaat     5520

cataatatta ttgaagcatt tatcagggtt cgtctcgtcc cggtctcctc ccatgcatg      5579


<210>  66
<211>  861
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  66

Met Asp Tyr Lys Asp His Asp Gly Asp Tyr Lys Asp His Asp Ile Asp 
1               5                   10                  15      


Tyr Lys Asp Asp Asp Asp Lys Ile Asp Gly Gly Gly Gly Ser Asp Pro 
            20                  25                  30          


Lys Lys Lys Arg Lys Val Asp Pro Lys Lys Lys Arg Lys Val Asp Pro 
        35                  40                  45              


Lys Lys Lys Arg Lys Val Gly Ser Thr Gly Ser Arg Asn Asp Gly Gly 
    50                  55                  60                  


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Arg Ala 
65                  70                  75                  80  


Gly Ile Leu Pro Pro Lys Lys Lys Arg Lys Val Ser Arg Gly Arg Ser 
                85                  90                  95      


Arg Leu Leu Glu Asp Phe Arg Asn Asn Arg Tyr Pro Asn Leu Gln Leu 
            100                 105                 110         


Arg Glu Ile Ala Gly His Ile Met Glu Phe Ser Gln Asp Gln His Gly 
        115                 120                 125             


Ser Arg Phe Ile Gln Leu Lys Leu Glu Arg Ala Thr Pro Ala Glu Arg 
    130                 135                 140                 


Gln Leu Val Phe Asn Glu Ile Leu Gln Ala Ala Tyr Gln Leu Met Val 
145                 150                 155                 160 


Asp Val Phe Gly Asn Tyr Val Ile Gln Lys Phe Phe Glu Phe Gly Ser 
                165                 170                 175     


Leu Glu Gln Lys Leu Ala Leu Ala Glu Arg Ile Arg Gly His Val Leu 
            180                 185                 190         


Ser Leu Ala Leu Gln Met Tyr Gly Ser Arg Val Ile Glu Lys Ala Leu 
        195                 200                 205             


Glu Phe Ile Pro Ser Asp Gln Gln Asn Glu Met Val Arg Glu Leu Asp 
    210                 215                 220                 


Gly His Val Leu Lys Cys Val Lys Asp Gln Asn Gly Asn His Val Val 
225                 230                 235                 240 


Gln Lys Cys Ile Glu Cys Val Gln Pro Gln Ser Leu Gln Phe Ile Ile 
                245                 250                 255     


Asp Ala Phe Lys Gly Gln Val Phe Ala Leu Ser Thr His Pro Tyr Gly 
            260                 265                 270         


Cys Arg Val Ile Gln Arg Ile Leu Glu His Cys Leu Pro Asp Gln Thr 
        275                 280                 285             


Leu Pro Ile Leu Glu Glu Leu His Gln His Thr Glu Gln Leu Val Gln 
    290                 295                 300                 


Asp Gln Tyr Gly Asn Tyr Val Ile Gln His Val Leu Glu His Gly Arg 
305                 310                 315                 320 


Pro Glu Asp Lys Ser Lys Ile Val Ala Glu Ile Arg Gly Asn Val Leu 
                325                 330                 335     


Val Leu Ser Gln His Lys Phe Ala Ser Asn Val Val Glu Lys Cys Val 
            340                 345                 350         


Thr His Ala Ser Arg Thr Glu Arg Ala Val Leu Ile Asp Glu Val Cys 
        355                 360                 365             


Thr Met Asn Asp Gly Pro His Ser Ala Leu Tyr Thr Met Met Lys Asp 
    370                 375                 380                 


Gln Tyr Ala Asn Tyr Val Val Gln Lys Met Ile Asp Val Ala Glu Pro 
385                 390                 395                 400 


Gly Gln Arg Lys Ile Val Met His Lys Ile Arg Pro His Ile Ala Thr 
                405                 410                 415     


Leu Arg Lys Tyr Thr Tyr Gly Lys His Ile Leu Ala Lys Leu Glu Lys 
            420                 425                 430         


Tyr Tyr Met Lys Asn Gly Val Asp Leu Gly Asp Pro Lys Lys Lys Arg 
        435                 440                 445             


Lys Val Asp Pro Lys Lys Lys Arg Lys Val Gly Gly Arg Gly Gly Gly 
    450                 455                 460                 


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Pro Ala Met 
465                 470                 475                 480 


Gly Ile Gln Gly Leu Ala Lys Leu Ile Ala Asp Val Ala Pro Ser Ala 
                485                 490                 495     


Ile Arg Glu Asn Asp Ile Lys Ser Tyr Phe Gly Arg Lys Val Ala Ile 
            500                 505                 510         


Asp Ala Ser Met Ser Ile Tyr Gln Phe Leu Ile Ala Val Arg Gln Gly 
        515                 520                 525             


Gly Asp Val Leu Gln Asn Glu Glu Gly Glu Thr Thr Ser His Leu Met 
    530                 535                 540                 


Gly Met Phe Tyr Arg Thr Ile Arg Met Met Glu Asn Gly Ile Lys Pro 
545                 550                 555                 560 


Val Tyr Val Phe Asp Gly Lys Pro Pro Gln Leu Lys Ser Gly Glu Leu 
                565                 570                 575     


Ala Lys Arg Ser Glu Arg Arg Ala Glu Ala Glu Lys Gln Leu Gln Gln 
            580                 585                 590         


Ala Gln Ala Ala Gly Ala Glu Gln Glu Val Glu Lys Phe Thr Lys Arg 
        595                 600                 605             


Leu Val Lys Val Thr Lys Gln His Asn Asp Glu Cys Lys His Leu Leu 
    610                 615                 620                 


Ser Leu Met Gly Ile Pro Tyr Leu Asp Ala Pro Ser Glu Ala Glu Ala 
625                 630                 635                 640 


Ser Cys Ala Ala Leu Val Lys Ala Gly Lys Val Tyr Ala Ala Ala Thr 
                645                 650                 655     


Glu Asp Met Asp Cys Leu Thr Phe Gly Ser Pro Val Leu Met Arg His 
            660                 665                 670         


Leu Thr Ala Ser Glu Ala Lys Lys Leu Pro Ile Gln Glu Phe His Leu 
        675                 680                 685             


Ser Arg Ile Leu Gln Glu Leu Gly Leu Asn Gln Glu Gln Phe Val Asp 
    690                 695                 700                 


Leu Cys Ile Leu Leu Gly Ser Asp Tyr Cys Glu Ser Ile Arg Gly Ile 
705                 710                 715                 720 


Gly Pro Lys Arg Ala Val Asp Leu Ile Gln Lys His Lys Ser Ile Glu 
                725                 730                 735     


Glu Ile Val Arg Arg Leu Asp Pro Asn Lys Tyr Pro Val Pro Glu Asn 
            740                 745                 750         


Trp Leu His Lys Glu Ala His Gln Leu Phe Leu Glu Pro Glu Val Leu 
        755                 760                 765             


Asp Pro Glu Ser Val Glu Leu Lys Trp Ser Glu Pro Asn Glu Glu Glu 
    770                 775                 780                 


Leu Ile Lys Phe Met Cys Gly Glu Lys Gln Phe Ser Glu Glu Arg Ile 
785                 790                 795                 800 


Arg Ser Gly Val Lys Arg Leu Ser Lys Ser Arg Gln Gly Ser Thr Gln 
                805                 810                 815     


Gly Arg Leu Asp Asp Phe Phe Lys Val Thr Gly Ser Leu Ser Ser Ala 
            820                 825                 830         


Lys Arg Lys Glu Pro Glu Pro Lys Gly Ser Thr Lys Lys Lys Ala Lys 
        835                 840                 845             


Thr Gly Ala Ala Gly Lys Phe Lys Arg Gly Lys Asn Val 
    850                 855                 860     


<210>  67
<211>  7016
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide

<400>  67
tcaatattgg ccattagcca tattattcat tggttatata gcataaatca atattggcta       60

ttggccattg catacgttgt atctatatca taatatgtac atttatattg gctcatgtcc      120

aatatgaccg ccatgttggc attgattatt gactagttat taatagtaat caattacggg      180

gtcattagtt catagcccat atatggagtt ccgcgttaca taacttacgg taaatggccc      240

gcctggctga ccgcccaacg acccccgccc attgacgtca ataatgacgt atgttcccat      300

agtaacgcca atagggactt tccattgacg tcaatgggtg gagtatttac ggtaaactgc      360

ccacttggca gtacatcaag tgtatcatat gccaagtccg ccccctattg acgtcaatga      420

cggtaaatgg cccgcctggc attatgccca gtacatgacc ttacgggact ttcctacttg      480

gcagtacatc tacgtattag tcatcgctat taccatggtg atgcggtttt ggcagtacac      540

caatgggcgt ggatagcggt ttgactcacg gggatttcca agtctccacc ccattgacgt      600

caatgggagt ttgttttggc accaaaatca acgggacttt ccaaaatgtc gtaataaccc      660

cgccccgttg acgcaaatgg gcggtaggcg tgtacggtgg gaggtctata taagcagagg      720

tcgtttagtg aaccgtcaga tcactagtag ctttattgcg gtagtttatc acagttaaat      780

tgctaacgca gtcagtgctc gactgatcac aggtaagtat caaggttaca agacaggttt      840

aaggaggcca atagaaactg ggcttgtcga gacagagaag attcttgcgt ttctgatagg      900

cacctattgg tcttactgac atccactttg cctttctctc cacagggaaa aaacaattga      960

caagtttgta caaaaaagca ggctccgaat tcaccggtgc cgccaccatg gactacaagg     1020

atcacgacgg tgactataag gatcatgaca tcgactataa ggacgatgac gataagatcg     1080

atggcggagg cggatctgat ccaaaaaaga agagaaaggt agatccaaaa aagaagagaa     1140

aggtagatcc aaaaaagaag agaaaggtag gatctaccgg atctagaaac gatggtggtg     1200

gtggaagcgg gggtgggggc agcggtggag ggggaagcgg gcgcgccggg atcctccccc     1260

ccaagaaaaa gaggaaggta tctagaggcc gcagccgcct tttggaagat tttcgaaaca     1320

accggtaccc caatttacaa ctgcgggaga ttgctggaca tataatggaa ttttcccaag     1380

accagcatgg gtccagattc attcagctga aactggagcg tgccacacca gctgagcgcc     1440

agcttgtctt caatgaaatc ctccaggctg cctaccaact catggtggat gtgtttggta     1500

attacgtcat tcagaagttc tttgaatttg gcagtcttga acagaagctg gctttggcag     1560

aacggattcg aggccacgtc ctgtcattgg cactacagat gtatggcagc cgtgttatcg     1620

agaaagctct tgagtttatt ccttcagacc agcagaatga gatggttcgg gaactagatg     1680

gccatgtctt gaagtgtgtg aaagatcaga atggcaatca cgtggttcag aaatgcattg     1740

aatgtgtaca gccccagtct ttgcaattta tcatcgacgc gtttaaggga caggtatttg     1800

ccttatccac acatccttat ggctgccgag tgattcagag aatcctggag cactgtctcc     1860

ctgaccagac actccctatt ttagaggagc ttcaccagca cacagagcag ctggtacagg     1920

atcaatatgg aaattatgta atccaacatg tactggagca cggtcgtcct gaggataaaa     1980

gcaaaattgt agcagaaatc cgaggcaatg tacttgtatt gagtcagcac aaatttgcaa     2040

gcaatgttgt ggagaagtgt gttactcacg cctcacgtac ggagcgcgct gtgctcatcg     2100

acgaggtgtg caccatgaac gacggtcccc acagtgcctt atacaccatg atgaaggacc     2160

agtatgccaa ctacgtggtc cagaagatga ttgacgtggc ggagccaggc cagcggaaga     2220

tcgtcatgca taagatccgg ccccacatcg caactcttcg taagtacacc tatggcaagc     2280

acattctggc caagctggag aagtactaca tgaagaacgg tgttgactta ggggacccaa     2340

agaagaagcg caaagtggat cctaaaaaga aaagaaaggt aggcggccgc gggggaggcg     2400

gttccggtgg cggcggaagc ggaggtggag gatcagggcc ggccatgact agcaaacaag     2460

caatgtcatc taacgaacaa gaaaggctct tgtgttataa tggggaagtc cttgttttcc     2520

agttgtctaa aggaaatttt gcagataaag agcctacaaa aacacccata ttacatgtca     2580

gaagaatggt atttgacaga ggaacaaaag tatttgttca gaagtccact ggatttttta     2640

ccataaagga agaaaactct catttaaaaa tcatgtgttg caactgtgtg tcagatttca     2700

gaactggaat taacctccct tacattgtga tagaaaaaaa taaaaagaat aatgtttttg     2760

aatatttttt actaatcctt cacagtacta ataaatttga aatgcgtttg agttttaaac     2820

taggctatga gatgaaggat ggcctaaggg tccttaatgg ccctttaatt ttatggaggc     2880

atgtcaaagc attcttcttt atctcttctc aaactggcaa agttgttagt gtgtcaggta     2940

acttttcctc tattcagtgg gcaggggaga ttgaaaattt aggtatggtt ttattgggac     3000

taaaggaatg ttgtttatct gaggaagaat gtactcaaga gccttcaaaa tcagattatg     3060

caatttggaa taccaaattt tgtgtatatt ctcttgaaag tcaagaagta ttaagtgata     3120

tatacattat tcctcctgct tacagcagtg tggtgactta tgtacatatt tgtgcaactg     3180

agatcatcaa aaaccagtta agaatatctc tcattgccct tactcgaaag aatcagctga     3240

tttcatttca gaatggaact cctaaaaatg tgtgccagct tccatttgga gatccttgtg     3300

cagttcaact tatggattca ggtggaggaa acctcttttt cgttgtatcc tttatatcca     3360

ataatgcttg tgctgtatgg aaagagagct ttcaggttgc tgctaaatgg gaaaaactta     3420

gcttagtact gatagatgac tttattggaa gtggaactga acaagtactc ctacttttta     3480

aggactcctt gaactcagac tgcctgactt catttaaaat aacggatctt ggaaaaataa     3540

actattcgag tgaaccatca gattgcaatg aagatgactt atttgaagac aaacaagaga     3600

atcgttacct ggtggttcca cctctagaaa caggactgaa agtttgtttt tcttcttttc     3660

gggaattacg gcagcatctg ttgcttaagg aaaaaattat ttcaaaatct tacaaagctt     3720

taataaacct agttcaagga aaagatgata atacgtcaag tgcagaggag aaggaatgtc     3780

ttgttcctct ttgtggtgaa gaagaaaatt ctgtccatat cttagatgaa aagttatcag     3840

acaattttca agattcagaa cagctagtag agaagatatg gtatcgtgta atagatgata     3900

gcttggttgt tggagtgaaa actacatctt ctttgaagct gtccctgaat gatgtgactt     3960

tatcattgtt aatggatcaa gcccatgact ccagatttcg gcttctaaag tgtcaaaata     4020

gggtgattaa gttgagtaca aatcctttcc cagcaccata cttgatgcca tgtgaaatag     4080

gattggaagc aaaaagggtc acgttgaccc ctgatagcaa gaaagaggaa agctttgttt     4140

gtgaacaccc atctaagaaa gagtgtgtac agataattac tgctgtaaca tctctttcac     4200

cacttttaac attcagtaaa ttttgttgca ctgtactgct acaaattatg gagagagaaa     4260

gtggtaactg tcctaaagat cgttatgttg tgtgtggcag agttttttta agtctagaag     4320

atctttcaac tgggaagtac ctactgacat ttccaaagaa gaaacctata gagcacatgg     4380

aagatctttt tgcacttctt gcagcattcc ataaatcttg ttttcaaatc acatcacccg     4440

gctatgccct gaattcaatg aaggtgtggc tcttagaaca tatgaaatgt gaaataatca     4500

aagaatttcc agaagtgtac ttttgtgaaa gaccgggaag tttctatggg acactcttca     4560

cttggaaaca gagaacacca ttcgaaggga ttttaataat ctattccagg aatcaaacag     4620

ttatgttcca gtgccttcat aatctcatca gaattctccc tataaactgt ttcctcaaaa     4680

atctaaaatc aggaagtgag aatttcctaa ttgataatat ggcatttact ttggagaagg     4740

aactagtcac ccttagttct ctttcttctg ccatagctaa acatgaaagc aattttatgc     4800

agaggtgtga agtgagcaaa ggaaagagta gtgtcgtcgc ggctgcttta tcagacagaa     4860

gggaaaatat ccatccctac agaaaagaac ttcagagaga aaagaagaaa atgttgcaaa     4920

cgaacctaaa agtgagtggt gccctttaca gagaaataac tttgaaagta gctgaggttc     4980

agttgaaatc agactttgct gcacagaaac tgagtaattt aaacgtttga ttaattaaga     5040

attcgaccca gctttcttgt acaaagtggt tgatatccag cacagtggcg gccgctcgag     5100

tctagagggc ccgcggttcg aaggtaagcc tatccctaac cctctcctcg gtctcgattc     5160

tacgcgtacc ggttagcaat tgttttttcg atgagtttgg acaaaccaca actagaatgc     5220

agtgaaaaaa atgctttatt tgtgaaattt gtgatgctat tgctttattt gtaaccatta     5280

taagctgcaa taaacaagtt aacaacaaca attgcattca ttttatgttt caggttcagg     5340

gggaggtgtg ggaggttttt taaagcaagt aaaacctcta caaatgtggt acttaagagg     5400

gggagaccaa agggcgagac gttaaggcct cacgtgacat gtgagcaaaa ggccagcaaa     5460

aggccaggaa ccgtaaaaag gccgcgttgc tggcgttttt ccataggctc cgcccccctg     5520

acgagcatca caaaaatcga cgctcaagtc agaggtggcg aaacccgaca ggactataaa     5580

gataccaggc gtttccccct ggaagctccc tcgtgcgctc tcctgttccg accctgccgc     5640

ttaccggata cctgtccgcc tttctccctt cgggaagcgt ggcgctttct catagctcac     5700

gctgtaggta tctcagttcg gtgtaggtcg ttcgctccaa gctgggctgt gtgcacgaac     5760

cccccgttca gcccgaccgc tgcgccttat ccggtaacta tcgtcttgag tccaacccgg     5820

taagacacga cttatcgcca ctggcagcag ccactggtaa caggattagc agagcgaggt     5880

atgtaggcgg tgctacagag ttcttgaagt ggtggcctaa ctacggctac actagaagga     5940

cagtatttgg tatctgcgct ctgctgaagc cagttacctt cggaaaaaga gttggtagct     6000

cttgatccgg caaacaaacc acgctggtag cggtggtttt tttgtttgca agcagcagat     6060

tacgcgcaga aaaaaaggat ctcaagaaga tcctttgatc ttttctacgg ggtctgacgc     6120

tcagtggaac gaaaactcac gttaagggat tttggtcatg ccgtctcaga agaactcgtc     6180

aagaaggcga tagaaggcga tgcgctgcga atcgggagcg gcgataccgt aaagcacgag     6240

gaagcggtca gcccattcgc cgccaagctc ttcagcaata tcacgggtag ccaacgctat     6300

gtcctgatag cggtccgcca cacccagccg gccacagtcg atgaatccag aaaagcggcc     6360

attttccacc atgatattcg gcaagcaggc atcgccatgg gtcacgacga gatcctcgcc     6420

gtcgggcatg ctcgccttga gcctggcgaa cagttcggct ggcgcgagcc cctgatgctc     6480

ttcgtccaga tcatcctgat cgacaagacc ggcttccatc cgagtacgtg ctcgctcgat     6540

gcgatgtttc gcttggtggt cgaatgggca ggtagccgga tcaagcgtat gcagccgccg     6600

cattgcatca gccatgatgg atactttctc ggcaggagca aggtgagatg acaggagatc     6660

ctgccccggc acttcgccca atagcagcca gtcccttccc gcttcagtga caacgtcgag     6720

cacagctgcg caaggaacgc ccgtcgtggc cagccacgat agccgcgctg cctcgtcttg     6780

cagttcattc agggcaccgg acaggtcggt cttgacaaaa agaaccgggc gcccctgcgc     6840

tgacagccgg aacacggcgg catcagagca gccgattgtc tgttgtgccc agtcatagcc     6900

gaatagcctc tccacccaag cggccggaga acctgcgtgc aatccatctt gttcaatcat     6960

aatattattg aagcatttat cagggttcgt ctcgtcccgg tctcctccca tgcatg         7016


<210>  68
<211>  1340
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  68

Met Asp Tyr Lys Asp His Asp Gly Asp Tyr Lys Asp His Asp Ile Asp 
1               5                   10                  15      


Tyr Lys Asp Asp Asp Asp Lys Ile Asp Gly Gly Gly Gly Ser Asp Pro 
            20                  25                  30          


Lys Lys Lys Arg Lys Val Asp Pro Lys Lys Lys Arg Lys Val Asp Pro 
        35                  40                  45              


Lys Lys Lys Arg Lys Val Gly Ser Thr Gly Ser Arg Asn Asp Gly Gly 
    50                  55                  60                  


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Arg Ala 
65                  70                  75                  80  


Gly Ile Leu Pro Pro Lys Lys Lys Arg Lys Val Ser Arg Gly Arg Ser 
                85                  90                  95      


Arg Leu Leu Glu Asp Phe Arg Asn Asn Arg Tyr Pro Asn Leu Gln Leu 
            100                 105                 110         


Arg Glu Ile Ala Gly His Ile Met Glu Phe Ser Gln Asp Gln His Gly 
        115                 120                 125             


Ser Arg Phe Ile Gln Leu Lys Leu Glu Arg Ala Thr Pro Ala Glu Arg 
    130                 135                 140                 


Gln Leu Val Phe Asn Glu Ile Leu Gln Ala Ala Tyr Gln Leu Met Val 
145                 150                 155                 160 


Asp Val Phe Gly Asn Tyr Val Ile Gln Lys Phe Phe Glu Phe Gly Ser 
                165                 170                 175     


Leu Glu Gln Lys Leu Ala Leu Ala Glu Arg Ile Arg Gly His Val Leu 
            180                 185                 190         


Ser Leu Ala Leu Gln Met Tyr Gly Ser Arg Val Ile Glu Lys Ala Leu 
        195                 200                 205             


Glu Phe Ile Pro Ser Asp Gln Gln Asn Glu Met Val Arg Glu Leu Asp 
    210                 215                 220                 


Gly His Val Leu Lys Cys Val Lys Asp Gln Asn Gly Asn His Val Val 
225                 230                 235                 240 


Gln Lys Cys Ile Glu Cys Val Gln Pro Gln Ser Leu Gln Phe Ile Ile 
                245                 250                 255     


Asp Ala Phe Lys Gly Gln Val Phe Ala Leu Ser Thr His Pro Tyr Gly 
            260                 265                 270         


Cys Arg Val Ile Gln Arg Ile Leu Glu His Cys Leu Pro Asp Gln Thr 
        275                 280                 285             


Leu Pro Ile Leu Glu Glu Leu His Gln His Thr Glu Gln Leu Val Gln 
    290                 295                 300                 


Asp Gln Tyr Gly Asn Tyr Val Ile Gln His Val Leu Glu His Gly Arg 
305                 310                 315                 320 


Pro Glu Asp Lys Ser Lys Ile Val Ala Glu Ile Arg Gly Asn Val Leu 
                325                 330                 335     


Val Leu Ser Gln His Lys Phe Ala Ser Asn Val Val Glu Lys Cys Val 
            340                 345                 350         


Thr His Ala Ser Arg Thr Glu Arg Ala Val Leu Ile Asp Glu Val Cys 
        355                 360                 365             


Thr Met Asn Asp Gly Pro His Ser Ala Leu Tyr Thr Met Met Lys Asp 
    370                 375                 380                 


Gln Tyr Ala Asn Tyr Val Val Gln Lys Met Ile Asp Val Ala Glu Pro 
385                 390                 395                 400 


Gly Gln Arg Lys Ile Val Met His Lys Ile Arg Pro His Ile Ala Thr 
                405                 410                 415     


Leu Arg Lys Tyr Thr Tyr Gly Lys His Ile Leu Ala Lys Leu Glu Lys 
            420                 425                 430         


Tyr Tyr Met Lys Asn Gly Val Asp Leu Gly Asp Pro Lys Lys Lys Arg 
        435                 440                 445             


Lys Val Asp Pro Lys Lys Lys Arg Lys Val Gly Gly Arg Gly Gly Gly 
    450                 455                 460                 


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Pro Ala Met 
465                 470                 475                 480 


Thr Ser Lys Gln Ala Met Ser Ser Asn Glu Gln Glu Arg Leu Leu Cys 
                485                 490                 495     


Tyr Asn Gly Glu Val Leu Val Phe Gln Leu Ser Lys Gly Asn Phe Ala 
            500                 505                 510         


Asp Lys Glu Pro Thr Lys Thr Pro Ile Leu His Val Arg Arg Met Val 
        515                 520                 525             


Phe Asp Arg Gly Thr Lys Val Phe Val Gln Lys Ser Thr Gly Phe Phe 
    530                 535                 540                 


Thr Ile Lys Glu Glu Asn Ser His Leu Lys Ile Met Cys Cys Asn Cys 
545                 550                 555                 560 


Val Ser Asp Phe Arg Thr Gly Ile Asn Leu Pro Tyr Ile Val Ile Glu 
                565                 570                 575     


Lys Asn Lys Lys Asn Asn Val Phe Glu Tyr Phe Leu Leu Ile Leu His 
            580                 585                 590         


Ser Thr Asn Lys Phe Glu Met Arg Leu Ser Phe Lys Leu Gly Tyr Glu 
        595                 600                 605             


Met Lys Asp Gly Leu Arg Val Leu Asn Gly Pro Leu Ile Leu Trp Arg 
    610                 615                 620                 


His Val Lys Ala Phe Phe Phe Ile Ser Ser Gln Thr Gly Lys Val Val 
625                 630                 635                 640 


Ser Val Ser Gly Asn Phe Ser Ser Ile Gln Trp Ala Gly Glu Ile Glu 
                645                 650                 655     


Asn Leu Gly Met Val Leu Leu Gly Leu Lys Glu Cys Cys Leu Ser Glu 
            660                 665                 670         


Glu Glu Cys Thr Gln Glu Pro Ser Lys Ser Asp Tyr Ala Ile Trp Asn 
        675                 680                 685             


Thr Lys Phe Cys Val Tyr Ser Leu Glu Ser Gln Glu Val Leu Ser Asp 
    690                 695                 700                 


Ile Tyr Ile Ile Pro Pro Ala Tyr Ser Ser Val Val Thr Tyr Val His 
705                 710                 715                 720 


Ile Cys Ala Thr Glu Ile Ile Lys Asn Gln Leu Arg Ile Ser Leu Ile 
                725                 730                 735     


Ala Leu Thr Arg Lys Asn Gln Leu Ile Ser Phe Gln Asn Gly Thr Pro 
            740                 745                 750         


Lys Asn Val Cys Gln Leu Pro Phe Gly Asp Pro Cys Ala Val Gln Leu 
        755                 760                 765             


Met Asp Ser Gly Gly Gly Asn Leu Phe Phe Val Val Ser Phe Ile Ser 
    770                 775                 780                 


Asn Asn Ala Cys Ala Val Trp Lys Glu Ser Phe Gln Val Ala Ala Lys 
785                 790                 795                 800 


Trp Glu Lys Leu Ser Leu Val Leu Ile Asp Asp Phe Ile Gly Ser Gly 
                805                 810                 815     


Thr Glu Gln Val Leu Leu Leu Phe Lys Asp Ser Leu Asn Ser Asp Cys 
            820                 825                 830         


Leu Thr Ser Phe Lys Ile Thr Asp Leu Gly Lys Ile Asn Tyr Ser Ser 
        835                 840                 845             


Glu Pro Ser Asp Cys Asn Glu Asp Asp Leu Phe Glu Asp Lys Gln Glu 
    850                 855                 860                 


Asn Arg Tyr Leu Val Val Pro Pro Leu Glu Thr Gly Leu Lys Val Cys 
865                 870                 875                 880 


Phe Ser Ser Phe Arg Glu Leu Arg Gln His Leu Leu Leu Lys Glu Lys 
                885                 890                 895     


Ile Ile Ser Lys Ser Tyr Lys Ala Leu Ile Asn Leu Val Gln Gly Lys 
            900                 905                 910         


Asp Asp Asn Thr Ser Ser Ala Glu Glu Lys Glu Cys Leu Val Pro Leu 
        915                 920                 925             


Cys Gly Glu Glu Glu Asn Ser Val His Ile Leu Asp Glu Lys Leu Ser 
    930                 935                 940                 


Asp Asn Phe Gln Asp Ser Glu Gln Leu Val Glu Lys Ile Trp Tyr Arg 
945                 950                 955                 960 


Val Ile Asp Asp Ser Leu Val Val Gly Val Lys Thr Thr Ser Ser Leu 
                965                 970                 975     


Lys Leu Ser Leu Asn Asp Val Thr Leu Ser Leu Leu Met Asp Gln Ala 
            980                 985                 990         


His Asp Ser Arg Phe Arg Leu Leu  Lys Cys Gln Asn Arg  Val Ile Lys 
        995                 1000                 1005             


Leu Ser  Thr Asn Pro Phe Pro  Ala Pro Tyr Leu Met  Pro Cys Glu 
    1010                 1015                 1020             


Ile Gly  Leu Glu Ala Lys Arg  Val Thr Leu Thr Pro  Asp Ser Lys 
    1025                 1030                 1035             


Lys Glu  Glu Ser Phe Val Cys  Glu His Pro Ser Lys  Lys Glu Cys 
    1040                 1045                 1050             


Val Gln  Ile Ile Thr Ala Val  Thr Ser Leu Ser Pro  Leu Leu Thr 
    1055                 1060                 1065             


Phe Ser  Lys Phe Cys Cys Thr  Val Leu Leu Gln Ile  Met Glu Arg 
    1070                 1075                 1080             


Glu Ser  Gly Asn Cys Pro Lys  Asp Arg Tyr Val Val  Cys Gly Arg 
    1085                 1090                 1095             


Val Phe  Leu Ser Leu Glu Asp  Leu Ser Thr Gly Lys  Tyr Leu Leu 
    1100                 1105                 1110             


Thr Phe  Pro Lys Lys Lys Pro  Ile Glu His Met Glu  Asp Leu Phe 
    1115                 1120                 1125             


Ala Leu  Leu Ala Ala Phe His  Lys Ser Cys Phe Gln  Ile Thr Ser 
    1130                 1135                 1140             


Pro Gly  Tyr Ala Leu Asn Ser  Met Lys Val Trp Leu  Leu Glu His 
    1145                 1150                 1155             


Met Lys  Cys Glu Ile Ile Lys  Glu Phe Pro Glu Val  Tyr Phe Cys 
    1160                 1165                 1170             


Glu Arg  Pro Gly Ser Phe Tyr  Gly Thr Leu Phe Thr  Trp Lys Gln 
    1175                 1180                 1185             


Arg Thr  Pro Phe Glu Gly Ile  Leu Ile Ile Tyr Ser  Arg Asn Gln 
    1190                 1195                 1200             


Thr Val  Met Phe Gln Cys Leu  His Asn Leu Ile Arg  Ile Leu Pro 
    1205                 1210                 1215             


Ile Asn  Cys Phe Leu Lys Asn  Leu Lys Ser Gly Ser  Glu Asn Phe 
    1220                 1225                 1230             


Leu Ile  Asp Asn Met Ala Phe  Thr Leu Glu Lys Glu  Leu Val Thr 
    1235                 1240                 1245             


Leu Ser  Ser Leu Ser Ser Ala  Ile Ala Lys His Glu  Ser Asn Phe 
    1250                 1255                 1260             


Met Gln  Arg Cys Glu Val Ser  Lys Gly Lys Ser Ser  Val Val Ala 
    1265                 1270                 1275             


Ala Ala  Leu Ser Asp Arg Arg  Glu Asn Ile His Pro  Tyr Arg Lys 
    1280                 1285                 1290             


Glu Leu  Gln Arg Glu Lys Lys  Lys Met Leu Gln Thr  Asn Leu Lys 
    1295                 1300                 1305             


Val Ser  Gly Ala Leu Tyr Arg  Glu Ile Thr Leu Lys  Val Ala Glu 
    1310                 1315                 1320             


Val Gln  Leu Lys Ser Asp Phe  Ala Ala Gln Lys Leu  Ser Asn Leu 
    1325                 1330                 1335             


Asn Val  
    1340 


<210>  69
<211>  5573
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide

<400>  69
tcaatattgg ccattagcca tattattcat tggttatata gcataaatca atattggcta       60

ttggccattg catacgttgt atctatatca taatatgtac atttatattg gctcatgtcc      120

aatatgaccg ccatgttggc attgattatt gactagttat taatagtaat caattacggg      180

gtcattagtt catagcccat atatggagtt ccgcgttaca taacttacgg taaatggccc      240

gcctggctga ccgcccaacg acccccgccc attgacgtca ataatgacgt atgttcccat      300

agtaacgcca atagggactt tccattgacg tcaatgggtg gagtatttac ggtaaactgc      360

ccacttggca gtacatcaag tgtatcatat gccaagtccg ccccctattg acgtcaatga      420

cggtaaatgg cccgcctggc attatgccca gtacatgacc ttacgggact ttcctacttg      480

gcagtacatc tacgtattag tcatcgctat taccatggtg atgcggtttt ggcagtacac      540

caatgggcgt ggatagcggt ttgactcacg gggatttcca agtctccacc ccattgacgt      600

caatgggagt ttgttttggc accaaaatca acgggacttt ccaaaatgtc gtaataaccc      660

cgccccgttg acgcaaatgg gcggtaggcg tgtacggtgg gaggtctata taagcagagg      720

tcgtttagtg aaccgtcaga tcactagtag ctttattgcg gtagtttatc acagttaaat      780

tgctaacgca gtcagtgctc gactgatcac aggtaagtat caaggttaca agacaggttt      840

aaggaggcca atagaaactg ggcttgtcga gacagagaag attcttgcgt ttctgatagg      900

cacctattgg tcttactgac atccactttg cctttctctc cacagggaaa aaacaattga      960

caagtttgta caaaaaagca ggctccgaat tcaccggtgc cgccaccatg gggccggcca     1020

tggaatccct tctgcagcac ctggatcgct tttccgagct tctggcggtc tcaagcacta     1080

cctacgtcag cacctgggac cccgccaccg tgcgccgggc cttgcagtgg gcgcgctacc     1140

tgcgccacat ccatcggcgc tttggtcggc atggccccat tcgcacggct ctggagcggc     1200

ggctgcacaa ccagtggagg caagagggcg gctttgggcg gggtccagtt ccgggattag     1260

cgaacttcca ggccctcggt cactgtgacg tcctgctctc tctgcgcctg ctggagaacc     1320

gggccctcgg ggatgcagct cgttaccacc tggtgcagca actctttccc ggcccgggcg     1380

tccgggacgc cgatgaggag acactccaag agagcctggc ccgccttgcc cgccggcggt     1440

ctgcggtgca catgctgcgc ttcaatggct atagagagaa cccaaatctc caggaggact     1500

ctctgatgaa gacccaggcg gagctgctgc tggagcgtct gcaggaggtg gggaaggccg     1560

aagcggagcg tcccgccagg tttctcagca gcctgtggga gcgcttgcct cagaacaact     1620

tcctgaaggt gatagcggtg gcgctgttgc agccgccttt gtctcgtcgg ccccaagaag     1680

agttggaacc cggcatccac aaatcacctg gagaggggag ccaagtgcta gtccactggc     1740

ttctggggaa ttcggaagtc tttgctgcct tttgtcgcgc cctcccagcc gggcttttga     1800

ctttagtgac tagccgccac ccagcgctgt ctcctgtcta tctgggtctg ctaacagact     1860

ggggtcaacg gttgcactat gaccttcaga aaggcatttg ggttggaact gagtcccaag     1920

atgtgccctg ggaggagttg cacaataggt ttcaaagcct ctgtcaggcc cctccacctc     1980

tgaaagataa agttctaact gccctggaga cctgtaaagc gcaggatgga gattttgaag     2040

tacctggtct tagcatctgg acagacctct tattagctct tcgtagtggt gcatttagga     2100

aaagacaagt tttgggtctc agcgcaggcc tcagttctgt aaacgttatc gatggcggag     2160

gcggatctga tccaaaaaag aagagaaagg tagatccaaa aaagaagaga aaggtagatc     2220

caaaaaagaa gagaaaggta ggatctaccg gatctagaaa cgatggtggt ggtggaagcg     2280

ggggtggggg cagcggtgga gggggaagcg ggcgcgccgg gatcctcccc cccaagaaaa     2340

agaggaaggt atctagaggc cgcagccgcc ttttggaaga ttttcgaaac aaccggtacc     2400

ccaatttaca actgcgggag attgctggac atataatgga attttcccaa gaccagcatg     2460

ggtccagatt cattcagctg aaactggagc gtgccacacc agctgagcgc cagcttgtct     2520

tcaatgaaat cctccaggct gcctaccaac tcatggtgga tgtgtttggt aattacgtca     2580

ttcagaagtt ctttgaattt ggcagtcttg aacagaagct ggctttggca gaacggattc     2640

gaggccacgt cctgtcattg gcactacaga tgtatggcag ccgtgttatc gagaaagctc     2700

ttgagtttat tccttcagac cagcagaatg agatggttcg ggaactagat ggccatgtct     2760

tgaagtgtgt gaaagatcag aatggcaatc acgtggttca gaaatgcatt gaatgtgtac     2820

agccccagtc tttgcaattt atcatcgacg cgtttaaggg acaggtattt gccttatcca     2880

cacatcctta tggctgccga gtgattcaga gaatcctgga gcactgtctc cctgaccaga     2940

cactccctat tttagaggag cttcaccagc acacagagca gctggtacag gatcaatatg     3000

gaaattatgt aatccaacat gtactggagc acggtcgtcc tgaggataaa agcaaaattg     3060

tagcagaaat ccgaggcaat gtacttgtat tgagtcagca caaatttgca agcaatgttg     3120

tggagaagtg tgttactcac gcctcacgta cggagcgcgc tgtgctcatc gacgaggtgt     3180

gcaccatgaa cgacggtccc cacagtgcct tatacaccat gatgaaggac cagtatgcca     3240

actacgtggt ccagaagatg attgacgtgg cggagccagg ccagcggaag atcgtcatgc     3300

ataagatccg gccccacatc gcaactcttc gtaagtacac ctatggcaag cacattctgg     3360

ccaagctgga gaagtactac atgaagaacg gtgttgactt aggggaccca aagaagaagc     3420

gcaaagtgga tcctaaaaag aaaagaaagg taggcggccg cgggggaggc ggttccggtg     3480

gcggcggaag cggaggtgga ggatcagggc cggccatgga ctacaaggat cacgacggtg     3540

actataagga tcatgacatc gactataagg acgatgacga taagtgatta attaagaatt     3600

cgacccagct ttcttgtaca aagtggttga tatccagcac agtggcggcc gctcgagtct     3660

agagggcccg cggttcgaag gtaagcctat ccctaaccct ctcctcggtc tcgattctac     3720

gcgtaccggt tagcaattgt tttttcgatg agtttggaca aaccacaact agaatgcagt     3780

gaaaaaaatg ctttatttgt gaaatttgtg atgctattgc tttatttgta accattataa     3840

gctgcaataa acaagttaac aacaacaatt gcattcattt tatgtttcag gttcaggggg     3900

aggtgtggga ggttttttaa agcaagtaaa acctctacaa atgtggtact taagaggggg     3960

agaccaaagg gcgagacgtt aaggcctcac gtgacatgtg agcaaaaggc cagcaaaagg     4020

ccaggaaccg taaaaaggcc gcgttgctgg cgtttttcca taggctccgc ccccctgacg     4080

agcatcacaa aaatcgacgc tcaagtcaga ggtggcgaaa cccgacagga ctataaagat     4140

accaggcgtt tccccctgga agctccctcg tgcgctctcc tgttccgacc ctgccgctta     4200

ccggatacct gtccgccttt ctcccttcgg gaagcgtggc gctttctcat agctcacgct     4260

gtaggtatct cagttcggtg taggtcgttc gctccaagct gggctgtgtg cacgaacccc     4320

ccgttcagcc cgaccgctgc gccttatccg gtaactatcg tcttgagtcc aacccggtaa     4380

gacacgactt atcgccactg gcagcagcca ctggtaacag gattagcaga gcgaggtatg     4440

taggcggtgc tacagagttc ttgaagtggt ggcctaacta cggctacact agaaggacag     4500

tatttggtat ctgcgctctg ctgaagccag ttaccttcgg aaaaagagtt ggtagctctt     4560

gatccggcaa acaaaccacg ctggtagcgg tggttttttt gtttgcaagc agcagattac     4620

gcgcagaaaa aaaggatctc aagaagatcc tttgatcttt tctacggggt ctgacgctca     4680

gtggaacgaa aactcacgtt aagggatttt ggtcatgccg tctcagaaga actcgtcaag     4740

aaggcgatag aaggcgatgc gctgcgaatc gggagcggcg ataccgtaaa gcacgaggaa     4800

gcggtcagcc cattcgccgc caagctcttc agcaatatca cgggtagcca acgctatgtc     4860

ctgatagcgg tccgccacac ccagccggcc acagtcgatg aatccagaaa agcggccatt     4920

ttccaccatg atattcggca agcaggcatc gccatgggtc acgacgagat cctcgccgtc     4980

gggcatgctc gccttgagcc tggcgaacag ttcggctggc gcgagcccct gatgctcttc     5040

gtccagatca tcctgatcga caagaccggc ttccatccga gtacgtgctc gctcgatgcg     5100

atgtttcgct tggtggtcga atgggcaggt agccggatca agcgtatgca gccgccgcat     5160

tgcatcagcc atgatggata ctttctcggc aggagcaagg tgagatgaca ggagatcctg     5220

ccccggcact tcgcccaata gcagccagtc ccttcccgct tcagtgacaa cgtcgagcac     5280

agctgcgcaa ggaacgcccg tcgtggccag ccacgatagc cgcgctgcct cgtcttgcag     5340

ttcattcagg gcaccggaca ggtcggtctt gacaaaaaga accgggcgcc cctgcgctga     5400

cagccggaac acggcggcat cagagcagcc gattgtctgt tgtgcccagt catagccgaa     5460

tagcctctcc acccaagcgg ccggagaacc tgcgtgcaat ccatcttgtt caatcataat     5520

attattgaag catttatcag ggttcgtctc gtcccggtct cctcccatgc atg            5573


<210>  70
<211>  859
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  70

Met Gly Pro Ala Met Glu Ser Leu Leu Gln His Leu Asp Arg Phe Ser 
1               5                   10                  15      


Glu Leu Leu Ala Val Ser Ser Thr Thr Tyr Val Ser Thr Trp Asp Pro 
            20                  25                  30          


Ala Thr Val Arg Arg Ala Leu Gln Trp Ala Arg Tyr Leu Arg His Ile 
        35                  40                  45              


His Arg Arg Phe Gly Arg His Gly Pro Ile Arg Thr Ala Leu Glu Arg 
    50                  55                  60                  


Arg Leu His Asn Gln Trp Arg Gln Glu Gly Gly Phe Gly Arg Gly Pro 
65                  70                  75                  80  


Val Pro Gly Leu Ala Asn Phe Gln Ala Leu Gly His Cys Asp Val Leu 
                85                  90                  95      


Leu Ser Leu Arg Leu Leu Glu Asn Arg Ala Leu Gly Asp Ala Ala Arg 
            100                 105                 110         


Tyr His Leu Val Gln Gln Leu Phe Pro Gly Pro Gly Val Arg Asp Ala 
        115                 120                 125             


Asp Glu Glu Thr Leu Gln Glu Ser Leu Ala Arg Leu Ala Arg Arg Arg 
    130                 135                 140                 


Ser Ala Val His Met Leu Arg Phe Asn Gly Tyr Arg Glu Asn Pro Asn 
145                 150                 155                 160 


Leu Gln Glu Asp Ser Leu Met Lys Thr Gln Ala Glu Leu Leu Leu Glu 
                165                 170                 175     


Arg Leu Gln Glu Val Gly Lys Ala Glu Ala Glu Arg Pro Ala Arg Phe 
            180                 185                 190         


Leu Ser Ser Leu Trp Glu Arg Leu Pro Gln Asn Asn Phe Leu Lys Val 
        195                 200                 205             


Ile Ala Val Ala Leu Leu Gln Pro Pro Leu Ser Arg Arg Pro Gln Glu 
    210                 215                 220                 


Glu Leu Glu Pro Gly Ile His Lys Ser Pro Gly Glu Gly Ser Gln Val 
225                 230                 235                 240 


Leu Val His Trp Leu Leu Gly Asn Ser Glu Val Phe Ala Ala Phe Cys 
                245                 250                 255     


Arg Ala Leu Pro Ala Gly Leu Leu Thr Leu Val Thr Ser Arg His Pro 
            260                 265                 270         


Ala Leu Ser Pro Val Tyr Leu Gly Leu Leu Thr Asp Trp Gly Gln Arg 
        275                 280                 285             


Leu His Tyr Asp Leu Gln Lys Gly Ile Trp Val Gly Thr Glu Ser Gln 
    290                 295                 300                 


Asp Val Pro Trp Glu Glu Leu His Asn Arg Phe Gln Ser Leu Cys Gln 
305                 310                 315                 320 


Ala Pro Pro Pro Leu Lys Asp Lys Val Leu Thr Ala Leu Glu Thr Cys 
                325                 330                 335     


Lys Ala Gln Asp Gly Asp Phe Glu Val Pro Gly Leu Ser Ile Trp Thr 
            340                 345                 350         


Asp Leu Leu Leu Ala Leu Arg Ser Gly Ala Phe Arg Lys Arg Gln Val 
        355                 360                 365             


Leu Gly Leu Ser Ala Gly Leu Ser Ser Val Asn Val Ile Asp Gly Gly 
    370                 375                 380                 


Gly Gly Ser Asp Pro Lys Lys Lys Arg Lys Val Asp Pro Lys Lys Lys 
385                 390                 395                 400 


Arg Lys Val Asp Pro Lys Lys Lys Arg Lys Val Gly Ser Thr Gly Ser 
                405                 410                 415     


Arg Asn Asp Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
            420                 425                 430         


Gly Ser Gly Arg Ala Gly Ile Leu Pro Pro Lys Lys Lys Arg Lys Val 
        435                 440                 445             


Ser Arg Gly Arg Ser Arg Leu Leu Glu Asp Phe Arg Asn Asn Arg Tyr 
    450                 455                 460                 


Pro Asn Leu Gln Leu Arg Glu Ile Ala Gly His Ile Met Glu Phe Ser 
465                 470                 475                 480 


Gln Asp Gln His Gly Ser Arg Phe Ile Gln Leu Lys Leu Glu Arg Ala 
                485                 490                 495     


Thr Pro Ala Glu Arg Gln Leu Val Phe Asn Glu Ile Leu Gln Ala Ala 
            500                 505                 510         


Tyr Gln Leu Met Val Asp Val Phe Gly Asn Tyr Val Ile Gln Lys Phe 
        515                 520                 525             


Phe Glu Phe Gly Ser Leu Glu Gln Lys Leu Ala Leu Ala Glu Arg Ile 
    530                 535                 540                 


Arg Gly His Val Leu Ser Leu Ala Leu Gln Met Tyr Gly Ser Arg Val 
545                 550                 555                 560 


Ile Glu Lys Ala Leu Glu Phe Ile Pro Ser Asp Gln Gln Asn Glu Met 
                565                 570                 575     


Val Arg Glu Leu Asp Gly His Val Leu Lys Cys Val Lys Asp Gln Asn 
            580                 585                 590         


Gly Asn His Val Val Gln Lys Cys Ile Glu Cys Val Gln Pro Gln Ser 
        595                 600                 605             


Leu Gln Phe Ile Ile Asp Ala Phe Lys Gly Gln Val Phe Ala Leu Ser 
    610                 615                 620                 


Thr His Pro Tyr Gly Cys Arg Val Ile Gln Arg Ile Leu Glu His Cys 
625                 630                 635                 640 


Leu Pro Asp Gln Thr Leu Pro Ile Leu Glu Glu Leu His Gln His Thr 
                645                 650                 655     


Glu Gln Leu Val Gln Asp Gln Tyr Gly Asn Tyr Val Ile Gln His Val 
            660                 665                 670         


Leu Glu His Gly Arg Pro Glu Asp Lys Ser Lys Ile Val Ala Glu Ile 
        675                 680                 685             


Arg Gly Asn Val Leu Val Leu Ser Gln His Lys Phe Ala Ser Asn Val 
    690                 695                 700                 


Val Glu Lys Cys Val Thr His Ala Ser Arg Thr Glu Arg Ala Val Leu 
705                 710                 715                 720 


Ile Asp Glu Val Cys Thr Met Asn Asp Gly Pro His Ser Ala Leu Tyr 
                725                 730                 735     


Thr Met Met Lys Asp Gln Tyr Ala Asn Tyr Val Val Gln Lys Met Ile 
            740                 745                 750         


Asp Val Ala Glu Pro Gly Gln Arg Lys Ile Val Met His Lys Ile Arg 
        755                 760                 765             


Pro His Ile Ala Thr Leu Arg Lys Tyr Thr Tyr Gly Lys His Ile Leu 
    770                 775                 780                 


Ala Lys Leu Glu Lys Tyr Tyr Met Lys Asn Gly Val Asp Leu Gly Asp 
785                 790                 795                 800 


Pro Lys Lys Lys Arg Lys Val Asp Pro Lys Lys Lys Arg Lys Val Gly 
                805                 810                 815     


Gly Arg Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
            820                 825                 830         


Ser Gly Pro Ala Met Asp Tyr Lys Asp His Asp Gly Asp Tyr Lys Asp 
        835                 840                 845             


His Asp Ile Asp Tyr Lys Asp Asp Asp Asp Lys 
    850                 855                 


<210>  71
<211>  5561
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide

<400>  71
tcaatattgg ccattagcca tattattcat tggttatata gcataaatca atattggcta       60

ttggccattg catacgttgt atctatatca taatatgtac atttatattg gctcatgtcc      120

aatatgaccg ccatgttggc attgattatt gactagttat taatagtaat caattacggg      180

gtcattagtt catagcccat atatggagtt ccgcgttaca taacttacgg taaatggccc      240

gcctggctga ccgcccaacg acccccgccc attgacgtca ataatgacgt atgttcccat      300

agtaacgcca atagggactt tccattgacg tcaatgggtg gagtatttac ggtaaactgc      360

ccacttggca gtacatcaag tgtatcatat gccaagtccg ccccctattg acgtcaatga      420

cggtaaatgg cccgcctggc attatgccca gtacatgacc ttacgggact ttcctacttg      480

gcagtacatc tacgtattag tcatcgctat taccatggtg atgcggtttt ggcagtacac      540

caatgggcgt ggatagcggt ttgactcacg gggatttcca agtctccacc ccattgacgt      600

caatgggagt ttgttttggc accaaaatca acgggacttt ccaaaatgtc gtaataaccc      660

cgccccgttg acgcaaatgg gcggtaggcg tgtacggtgg gaggtctata taagcagagg      720

tcgtttagtg aaccgtcaga tcactagtag ctttattgcg gtagtttatc acagttaaat      780

tgctaacgca gtcagtgctc gactgatcac aggtaagtat caaggttaca agacaggttt      840

aaggaggcca atagaaactg ggcttgtcga gacagagaag attcttgcgt ttctgatagg      900

cacctattgg tcttactgac atccactttg cctttctctc cacagggaaa aaacaattga      960

caagtttgta caaaaaagca ggctccgaat tcaccggtgc cgccaccatg gactacaagg     1020

atcacgacgg tgactataag gatcatgaca tcgactataa ggacgatgac gataagatcg     1080

atggcggagg cggatctgat ccaaaaaaga agagaaaggt agatccaaaa aagaagagaa     1140

aggtagatcc aaaaaagaag agaaaggtag gatctaccgg atctagaaac gatggtggtg     1200

gtggaagcgg gggtgggggc agcggtggag ggggaagcgg gcgcgccggg atcctccccc     1260

ccaagaaaaa gaggaaggta tctagaggcc gcagccgcct tttggaagat tttcgaaaca     1320

accggtaccc caatttacaa ctgcgggaga ttgctggaca tataatggaa ttttcccaag     1380

accagcatgg gtccagattc attcagctga aactggagcg tgccacacca gctgagcgcc     1440

agcttgtctt caatgaaatc ctccaggctg cctaccaact catggtggat gtgtttggta     1500

attacgtcat tcagaagttc tttgaatttg gcagtcttga acagaagctg gctttggcag     1560

aacggattcg aggccacgtc ctgtcattgg cactacagat gtatggcagc cgtgttatcg     1620

agaaagctct tgagtttatt ccttcagacc agcagaatga gatggttcgg gaactagatg     1680

gccatgtctt gaagtgtgtg aaagatcaga atggcaatca cgtggttcag aaatgcattg     1740

aatgtgtaca gccccagtct ttgcaattta tcatcgacgc gtttaaggga caggtatttg     1800

ccttatccac acatccttat ggctgccgag tgattcagag aatcctggag cactgtctcc     1860

ctgaccagac actccctatt ttagaggagc ttcaccagca cacagagcag ctggtacagg     1920

atcaatatgg aaattatgta atccaacatg tactggagca cggtcgtcct gaggataaaa     1980

gcaaaattgt agcagaaatc cgaggcaatg tacttgtatt gagtcagcac aaatttgcaa     2040

gcaatgttgt ggagaagtgt gttactcacg cctcacgtac ggagcgcgct gtgctcatcg     2100

acgaggtgtg caccatgaac gacggtcccc acagtgcctt atacaccatg atgaaggacc     2160

agtatgccaa ctacgtggtc cagaagatga ttgacgtggc ggagccaggc cagcggaaga     2220

tcgtcatgca taagatccgg ccccacatcg caactcttcg taagtacacc tatggcaagc     2280

acattctggc caagctggag aagtactaca tgaagaacgg tgttgactta ggggacccaa     2340

agaagaagcg caaagtggat cctaaaaaga aaagaaaggt aggcggccgc gggggaggcg     2400

gttccggtgg cggcggaagc ggaggtggag gatcagggcc ggccatggaa tcccttctgc     2460

agcacctgga tcgcttttcc gagcttctgg cggtctcaag cactacctac gtcagcacct     2520

gggaccccgc caccgtgcgc cgggccttgc agtgggcgcg ctacctgcgc cacatccatc     2580

ggcgctttgg tcggcatggc cccattcgca cggctctgga gcggcggctg cacaaccagt     2640

ggaggcaaga gggcggcttt gggcggggtc cagttccggg attagcgaac ttccaggccc     2700

tcggtcactg tgacgtcctg ctctctctgc gcctgctgga gaaccgggcc ctcggggatg     2760

cagctcgtta ccacctggtg cagcaactct ttcccggccc gggcgtccgg gacgccgatg     2820

aggagacact ccaagagagc ctggcccgcc ttgcccgccg gcggtctgcg gtgcacatgc     2880

tgcgcttcaa tggctataga gagaacccaa atctccagga ggactctctg atgaagaccc     2940

aggcggagct gctgctggag cgtctgcagg aggtggggaa ggccgaagcg gagcgtcccg     3000

ccaggtttct cagcagcctg tgggagcgct tgcctcagaa caacttcctg aaggtgatag     3060

cggtggcgct gttgcagccg cctttgtctc gtcggcccca agaagagttg gaacccggca     3120

tccacaaatc acctggagag gggagccaag tgctagtcca ctggcttctg gggaattcgg     3180

aagtctttgc tgccttttgt cgcgccctcc cagccgggct tttgacttta gtgactagcc     3240

gccacccagc gctgtctcct gtctatctgg gtctgctaac agactggggt caacggttgc     3300

actatgacct tcagaaaggc atttgggttg gaactgagtc ccaagatgtg ccctgggagg     3360

agttgcacaa taggtttcaa agcctctgtc aggcccctcc acctctgaaa gataaagttc     3420

taactgccct ggagacctgt aaagcgcagg atggagattt tgaagtacct ggtcttagca     3480

tctggacaga cctcttatta gctcttcgta gtggtgcatt taggaaaaga caagttttgg     3540

gtctcagcgc aggcctcagt tctgtaaacg tttgattaat taagaattcg acccagcttt     3600

cttgtacaaa gtggttgata tccagcacag tggcggccgc tcgagtctag agggcccgcg     3660

gttcgaaggt aagcctatcc ctaaccctct cctcggtctc gattctacgc gtaccggtta     3720

gcaattgttt tttcgatgag tttggacaaa ccacaactag aatgcagtga aaaaaatgct     3780

ttatttgtga aatttgtgat gctattgctt tatttgtaac cattataagc tgcaataaac     3840

aagttaacaa caacaattgc attcatttta tgtttcaggt tcagggggag gtgtgggagg     3900

ttttttaaag caagtaaaac ctctacaaat gtggtactta agagggggag accaaagggc     3960

gagacgttaa ggcctcacgt gacatgtgag caaaaggcca gcaaaaggcc aggaaccgta     4020

aaaaggccgc gttgctggcg tttttccata ggctccgccc ccctgacgag catcacaaaa     4080

atcgacgctc aagtcagagg tggcgaaacc cgacaggact ataaagatac caggcgtttc     4140

cccctggaag ctccctcgtg cgctctcctg ttccgaccct gccgcttacc ggatacctgt     4200

ccgcctttct cccttcggga agcgtggcgc tttctcatag ctcacgctgt aggtatctca     4260

gttcggtgta ggtcgttcgc tccaagctgg gctgtgtgca cgaacccccc gttcagcccg     4320

accgctgcgc cttatccggt aactatcgtc ttgagtccaa cccggtaaga cacgacttat     4380

cgccactggc agcagccact ggtaacagga ttagcagagc gaggtatgta ggcggtgcta     4440

cagagttctt gaagtggtgg cctaactacg gctacactag aaggacagta tttggtatct     4500

gcgctctgct gaagccagtt accttcggaa aaagagttgg tagctcttga tccggcaaac     4560

aaaccacgct ggtagcggtg gtttttttgt ttgcaagcag cagattacgc gcagaaaaaa     4620

aggatctcaa gaagatcctt tgatcttttc tacggggtct gacgctcagt ggaacgaaaa     4680

ctcacgttaa gggattttgg tcatgccgtc tcagaagaac tcgtcaagaa ggcgatagaa     4740

ggcgatgcgc tgcgaatcgg gagcggcgat accgtaaagc acgaggaagc ggtcagccca     4800

ttcgccgcca agctcttcag caatatcacg ggtagccaac gctatgtcct gatagcggtc     4860

cgccacaccc agccggccac agtcgatgaa tccagaaaag cggccatttt ccaccatgat     4920

attcggcaag caggcatcgc catgggtcac gacgagatcc tcgccgtcgg gcatgctcgc     4980

cttgagcctg gcgaacagtt cggctggcgc gagcccctga tgctcttcgt ccagatcatc     5040

ctgatcgaca agaccggctt ccatccgagt acgtgctcgc tcgatgcgat gtttcgcttg     5100

gtggtcgaat gggcaggtag ccggatcaag cgtatgcagc cgccgcattg catcagccat     5160

gatggatact ttctcggcag gagcaaggtg agatgacagg agatcctgcc ccggcacttc     5220

gcccaatagc agccagtccc ttcccgcttc agtgacaacg tcgagcacag ctgcgcaagg     5280

aacgcccgtc gtggccagcc acgatagccg cgctgcctcg tcttgcagtt cattcagggc     5340

accggacagg tcggtcttga caaaaagaac cgggcgcccc tgcgctgaca gccggaacac     5400

ggcggcatca gagcagccga ttgtctgttg tgcccagtca tagccgaata gcctctccac     5460

ccaagcggcc ggagaacctg cgtgcaatcc atcttgttca atcataatat tattgaagca     5520

tttatcaggg ttcgtctcgt cccggtctcc tcccatgcat g                         5561


<210>  72
<211>  855
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  72

Met Asp Tyr Lys Asp His Asp Gly Asp Tyr Lys Asp His Asp Ile Asp 
1               5                   10                  15      


Tyr Lys Asp Asp Asp Asp Lys Ile Asp Gly Gly Gly Gly Ser Asp Pro 
            20                  25                  30          


Lys Lys Lys Arg Lys Val Asp Pro Lys Lys Lys Arg Lys Val Asp Pro 
        35                  40                  45              


Lys Lys Lys Arg Lys Val Gly Ser Thr Gly Ser Arg Asn Asp Gly Gly 
    50                  55                  60                  


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Arg Ala 
65                  70                  75                  80  


Gly Ile Leu Pro Pro Lys Lys Lys Arg Lys Val Ser Arg Gly Arg Ser 
                85                  90                  95      


Arg Leu Leu Glu Asp Phe Arg Asn Asn Arg Tyr Pro Asn Leu Gln Leu 
            100                 105                 110         


Arg Glu Ile Ala Gly His Ile Met Glu Phe Ser Gln Asp Gln His Gly 
        115                 120                 125             


Ser Arg Phe Ile Gln Leu Lys Leu Glu Arg Ala Thr Pro Ala Glu Arg 
    130                 135                 140                 


Gln Leu Val Phe Asn Glu Ile Leu Gln Ala Ala Tyr Gln Leu Met Val 
145                 150                 155                 160 


Asp Val Phe Gly Asn Tyr Val Ile Gln Lys Phe Phe Glu Phe Gly Ser 
                165                 170                 175     


Leu Glu Gln Lys Leu Ala Leu Ala Glu Arg Ile Arg Gly His Val Leu 
            180                 185                 190         


Ser Leu Ala Leu Gln Met Tyr Gly Ser Arg Val Ile Glu Lys Ala Leu 
        195                 200                 205             


Glu Phe Ile Pro Ser Asp Gln Gln Asn Glu Met Val Arg Glu Leu Asp 
    210                 215                 220                 


Gly His Val Leu Lys Cys Val Lys Asp Gln Asn Gly Asn His Val Val 
225                 230                 235                 240 


Gln Lys Cys Ile Glu Cys Val Gln Pro Gln Ser Leu Gln Phe Ile Ile 
                245                 250                 255     


Asp Ala Phe Lys Gly Gln Val Phe Ala Leu Ser Thr His Pro Tyr Gly 
            260                 265                 270         


Cys Arg Val Ile Gln Arg Ile Leu Glu His Cys Leu Pro Asp Gln Thr 
        275                 280                 285             


Leu Pro Ile Leu Glu Glu Leu His Gln His Thr Glu Gln Leu Val Gln 
    290                 295                 300                 


Asp Gln Tyr Gly Asn Tyr Val Ile Gln His Val Leu Glu His Gly Arg 
305                 310                 315                 320 


Pro Glu Asp Lys Ser Lys Ile Val Ala Glu Ile Arg Gly Asn Val Leu 
                325                 330                 335     


Val Leu Ser Gln His Lys Phe Ala Ser Asn Val Val Glu Lys Cys Val 
            340                 345                 350         


Thr His Ala Ser Arg Thr Glu Arg Ala Val Leu Ile Asp Glu Val Cys 
        355                 360                 365             


Thr Met Asn Asp Gly Pro His Ser Ala Leu Tyr Thr Met Met Lys Asp 
    370                 375                 380                 


Gln Tyr Ala Asn Tyr Val Val Gln Lys Met Ile Asp Val Ala Glu Pro 
385                 390                 395                 400 


Gly Gln Arg Lys Ile Val Met His Lys Ile Arg Pro His Ile Ala Thr 
                405                 410                 415     


Leu Arg Lys Tyr Thr Tyr Gly Lys His Ile Leu Ala Lys Leu Glu Lys 
            420                 425                 430         


Tyr Tyr Met Lys Asn Gly Val Asp Leu Gly Asp Pro Lys Lys Lys Arg 
        435                 440                 445             


Lys Val Asp Pro Lys Lys Lys Arg Lys Val Gly Gly Arg Gly Gly Gly 
    450                 455                 460                 


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Pro Ala Met 
465                 470                 475                 480 


Glu Ser Leu Leu Gln His Leu Asp Arg Phe Ser Glu Leu Leu Ala Val 
                485                 490                 495     


Ser Ser Thr Thr Tyr Val Ser Thr Trp Asp Pro Ala Thr Val Arg Arg 
            500                 505                 510         


Ala Leu Gln Trp Ala Arg Tyr Leu Arg His Ile His Arg Arg Phe Gly 
        515                 520                 525             


Arg His Gly Pro Ile Arg Thr Ala Leu Glu Arg Arg Leu His Asn Gln 
    530                 535                 540                 


Trp Arg Gln Glu Gly Gly Phe Gly Arg Gly Pro Val Pro Gly Leu Ala 
545                 550                 555                 560 


Asn Phe Gln Ala Leu Gly His Cys Asp Val Leu Leu Ser Leu Arg Leu 
                565                 570                 575     


Leu Glu Asn Arg Ala Leu Gly Asp Ala Ala Arg Tyr His Leu Val Gln 
            580                 585                 590         


Gln Leu Phe Pro Gly Pro Gly Val Arg Asp Ala Asp Glu Glu Thr Leu 
        595                 600                 605             


Gln Glu Ser Leu Ala Arg Leu Ala Arg Arg Arg Ser Ala Val His Met 
    610                 615                 620                 


Leu Arg Phe Asn Gly Tyr Arg Glu Asn Pro Asn Leu Gln Glu Asp Ser 
625                 630                 635                 640 


Leu Met Lys Thr Gln Ala Glu Leu Leu Leu Glu Arg Leu Gln Glu Val 
                645                 650                 655     


Gly Lys Ala Glu Ala Glu Arg Pro Ala Arg Phe Leu Ser Ser Leu Trp 
            660                 665                 670         


Glu Arg Leu Pro Gln Asn Asn Phe Leu Lys Val Ile Ala Val Ala Leu 
        675                 680                 685             


Leu Gln Pro Pro Leu Ser Arg Arg Pro Gln Glu Glu Leu Glu Pro Gly 
    690                 695                 700                 


Ile His Lys Ser Pro Gly Glu Gly Ser Gln Val Leu Val His Trp Leu 
705                 710                 715                 720 


Leu Gly Asn Ser Glu Val Phe Ala Ala Phe Cys Arg Ala Leu Pro Ala 
                725                 730                 735     


Gly Leu Leu Thr Leu Val Thr Ser Arg His Pro Ala Leu Ser Pro Val 
            740                 745                 750         


Tyr Leu Gly Leu Leu Thr Asp Trp Gly Gln Arg Leu His Tyr Asp Leu 
        755                 760                 765             


Gln Lys Gly Ile Trp Val Gly Thr Glu Ser Gln Asp Val Pro Trp Glu 
    770                 775                 780                 


Glu Leu His Asn Arg Phe Gln Ser Leu Cys Gln Ala Pro Pro Pro Leu 
785                 790                 795                 800 


Lys Asp Lys Val Leu Thr Ala Leu Glu Thr Cys Lys Ala Gln Asp Gly 
                805                 810                 815     


Asp Phe Glu Val Pro Gly Leu Ser Ile Trp Thr Asp Leu Leu Leu Ala 
            820                 825                 830         


Leu Arg Ser Gly Ala Phe Arg Lys Arg Gln Val Leu Gly Leu Ser Ala 
        835                 840                 845             


Gly Leu Ser Ser Val Asn Val 
    850                 855 


<210>  73
<211>  6317
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide

<400>  73
tcaatattgg ccattagcca tattattcat tggttatata gcataaatca atattggcta       60

ttggccattg catacgttgt atctatatca taatatgtac atttatattg gctcatgtcc      120

aatatgaccg ccatgttggc attgattatt gactagttat taatagtaat caattacggg      180

gtcattagtt catagcccat atatggagtt ccgcgttaca taacttacgg taaatggccc      240

gcctggctga ccgcccaacg acccccgccc attgacgtca ataatgacgt atgttcccat      300

agtaacgcca atagggactt tccattgacg tcaatgggtg gagtatttac ggtaaactgc      360

ccacttggca gtacatcaag tgtatcatat gccaagtccg ccccctattg acgtcaatga      420

cggtaaatgg cccgcctggc attatgccca gtacatgacc ttacgggact ttcctacttg      480

gcagtacatc tacgtattag tcatcgctat taccatggtg atgcggtttt ggcagtacac      540

caatgggcgt ggatagcggt ttgactcacg gggatttcca agtctccacc ccattgacgt      600

caatgggagt ttgttttggc accaaaatca acgggacttt ccaaaatgtc gtaataaccc      660

cgccccgttg acgcaaatgg gcggtaggcg tgtacggtgg gaggtctata taagcagagg      720

tcgtttagtg aaccgtcaga tcactagtag ctttattgcg gtagtttatc acagttaaat      780

tgctaacgca gtcagtgctc gactgatcac aggtaagtat caaggttaca agacaggttt      840

aaggaggcca atagaaactg ggcttgtcga gacagagaag attcttgcgt ttctgatagg      900

cacctattgg tcttactgac atccactttg cctttctctc cacagggaaa aaacaattga      960

caagtttgta caaaaaagca ggctccgaat tcaccggtgc cgccaccatg gggccggcca     1020

tgtcccgcca gaccacctct gtgggctcca gctgcctgga cctgtggagg gaaaagaatg     1080

accggctcgt tcgacaggcc aaggtggctc agaactccgg tctgactctg aggcgacagc     1140

agttggctca ggatgcactg gaagggctca gagggctcct ccatagtctg caagggctcc     1200

ctgcagctgt tcctgttctt cccttggagc tgactgtcac ctgcaacttc attatcctga     1260

gggcaagctt ggcccagggt ttcacagagg atcaggccca ggatatccag cggagcctag     1320

agagagtgct ggagacacag gagcagcagg ggcccaggtt ggaacagggg ctcagggagc     1380

tgtgggactc tgtccttcgt gcttcctgcc ttctgccgga gctgctgtct gccctgcacc     1440

gcctggttgg cctgcaggct gccctctggt tgagtgctga ccgtcttggg gacctggcct     1500

tgttactaga gaccctgaat ggcagccaga gtggagcctc taaggatctg ctgttacttc     1560

tgaaaacttg gagtccccca gctgaggaat tagatgctcc attgaccctg caggatgccc     1620

agggattgaa ggatgtcctc ctgacagcat ttgcctaccg ccaaggtctc caggagctga     1680

tcacagggaa cccagacaag gcactaagca gccttcatga agcggcctca ggcctgtgtc     1740

cacggcctgt gttggtccag gtgtacacag cactggggtc ctgtcaccgt aagatgggaa     1800

atccacagag agcactgttg tacttggttg cagccctgaa agagggatca gcctggggtc     1860

ctccacttct ggaggcctct aggctctatc agcaactggg ggacacaaca gcagagctgg     1920

agagtctgga gctgctagtt gaggccttga atgtcccatg cagttccaaa gccccgcagt     1980

ttctcattga ggtagaatta ctactgccac cacctgacct agcctcaccc cttcattgtg     2040

gcactcagag ccagaccaag cacatactag caagcaggtg cctacagacg gggagggcag     2100

gagacgctgc agagcattac ttggacctgc tggccctgtt gctggatagc tcggagccaa     2160

ggttctcccc acccccctcc cctccagggc cctgtatgcc tgaggtgttt ttggaggcag     2220

cggtagcact gatccaggca ggcagagccc aagatgcctt gactctatgt gaggagttgc     2280

tcagccgcac atcatctctg ctacccaaga tgtcccggct gtgggaagat gccagaaaag     2340

gaaccaagga actgccatac tgcccactct gggtctctgc cacccacctg cttcagggcc     2400

aggcctgggt tcaactgggt gcccaaaaag tggcaattag tgaatttagc aggtgcctcg     2460

agctgctctt ccgggccaca cctgaggaaa aagaacaagg ggcagctttc aactgtgagc     2520

agggatgtaa gtcagatgcg gcactgcagc agcttcgggc agccgcccta attagtcgtg     2580

gactggaatg ggtagccagc ggccaggata ccaaagcctt acaggacttc ctcctcagtg     2640

tgcagatgtg cccaggtaat cgagacactt actttcacct gcttcagact ctgaagaggc     2700

tagatcggag ggatgaggcc actgcactct ggtggaggct ggaggcccaa actaaggggt     2760

cacatgaaga tgctctgtgg tctctccccc tgtacctaga aagctatttg agctggatcc     2820

gtccctctga tcgtgacgcc ttccttgaag aatttcggac atctctgcca aagtcttgtg     2880

acctgaacgt tatcgatggc ggaggcggat ctgatccaaa aaagaagaga aaggtagatc     2940

caaaaaagaa gagaaaggta gatccaaaaa agaagagaaa ggtaggatct accggatcta     3000

gaaacgatgg tggtggtgga agcgggggtg ggggcagcgg tggaggggga agcgggcgcg     3060

ccgggatcct cccccccaag aaaaagagga aggtatctag aggccgcagc cgccttttgg     3120

aagattttcg aaacaaccgg taccccaatt tacaactgcg ggagattgct ggacatataa     3180

tggaattttc ccaagaccag catgggtcca gattcattca gctgaaactg gagcgtgcca     3240

caccagctga gcgccagctt gtcttcaatg aaatcctcca ggctgcctac caactcatgg     3300

tggatgtgtt tggtaattac gtcattcaga agttctttga atttggcagt cttgaacaga     3360

agctggcttt ggcagaacgg attcgaggcc acgtcctgtc attggcacta cagatgtatg     3420

gcagccgtgt tatcgagaaa gctcttgagt ttattccttc agaccagcag aatgagatgg     3480

ttcgggaact agatggccat gtcttgaagt gtgtgaaaga tcagaatggc aatcacgtgg     3540

ttcagaaatg cattgaatgt gtacagcccc agtctttgca atttatcatc gacgcgttta     3600

agggacaggt atttgcctta tccacacatc cttatggctg ccgagtgatt cagagaatcc     3660

tggagcactg tctccctgac cagacactcc ctattttaga ggagcttcac cagcacacag     3720

agcagctggt acaggatcaa tatggaaatt atgtaatcca acatgtactg gagcacggtc     3780

gtcctgagga taaaagcaaa attgtagcag aaatccgagg caatgtactt gtattgagtc     3840

agcacaaatt tgcaagcaat gttgtggaga agtgtgttac tcacgcctca cgtacggagc     3900

gcgctgtgct catcgacgag gtgtgcacca tgaacgacgg tccccacagt gccttataca     3960

ccatgatgaa ggaccagtat gccaactacg tggtccagaa gatgattgac gtggcggagc     4020

caggccagcg gaagatcgtc atgcataaga tccggcccca catcgcaact cttcgtaagt     4080

acacctatgg caagcacatt ctggccaagc tggagaagta ctacatgaag aacggtgttg     4140

acttagggga cccaaagaag aagcgcaaag tggatcctaa aaagaaaaga aaggtaggcg     4200

gccgcggggg aggcggttcc ggtggcggcg gaagcggagg tggaggatca gggccggcca     4260

tggactacaa ggatcacgac ggtgactata aggatcatga catcgactat aaggacgatg     4320

acgataagtg attaattaag aattcgaccc agctttcttg tacaaagtgg ttgatatcca     4380

gcacagtggc ggccgctcga gtctagaggg cccgcggttc gaaggtaagc ctatccctaa     4440

ccctctcctc ggtctcgatt ctacgcgtac cggttagcaa ttgttttttc gatgagtttg     4500

gacaaaccac aactagaatg cagtgaaaaa aatgctttat ttgtgaaatt tgtgatgcta     4560

ttgctttatt tgtaaccatt ataagctgca ataaacaagt taacaacaac aattgcattc     4620

attttatgtt tcaggttcag ggggaggtgt gggaggtttt ttaaagcaag taaaacctct     4680

acaaatgtgg tacttaagag ggggagacca aagggcgaga cgttaaggcc tcacgtgaca     4740

tgtgagcaaa aggccagcaa aaggccagga accgtaaaaa ggccgcgttg ctggcgtttt     4800

tccataggct ccgcccccct gacgagcatc acaaaaatcg acgctcaagt cagaggtggc     4860

gaaacccgac aggactataa agataccagg cgtttccccc tggaagctcc ctcgtgcgct     4920

ctcctgttcc gaccctgccg cttaccggat acctgtccgc ctttctccct tcgggaagcg     4980

tggcgctttc tcatagctca cgctgtaggt atctcagttc ggtgtaggtc gttcgctcca     5040

agctgggctg tgtgcacgaa ccccccgttc agcccgaccg ctgcgcctta tccggtaact     5100

atcgtcttga gtccaacccg gtaagacacg acttatcgcc actggcagca gccactggta     5160

acaggattag cagagcgagg tatgtaggcg gtgctacaga gttcttgaag tggtggccta     5220

actacggcta cactagaagg acagtatttg gtatctgcgc tctgctgaag ccagttacct     5280

tcggaaaaag agttggtagc tcttgatccg gcaaacaaac cacgctggta gcggtggttt     5340

ttttgtttgc aagcagcaga ttacgcgcag aaaaaaagga tctcaagaag atcctttgat     5400

cttttctacg gggtctgacg ctcagtggaa cgaaaactca cgttaaggga ttttggtcat     5460

gccgtctcag aagaactcgt caagaaggcg atagaaggcg atgcgctgcg aatcgggagc     5520

ggcgataccg taaagcacga ggaagcggtc agcccattcg ccgccaagct cttcagcaat     5580

atcacgggta gccaacgcta tgtcctgata gcggtccgcc acacccagcc ggccacagtc     5640

gatgaatcca gaaaagcggc cattttccac catgatattc ggcaagcagg catcgccatg     5700

ggtcacgacg agatcctcgc cgtcgggcat gctcgccttg agcctggcga acagttcggc     5760

tggcgcgagc ccctgatgct cttcgtccag atcatcctga tcgacaagac cggcttccat     5820

ccgagtacgt gctcgctcga tgcgatgttt cgcttggtgg tcgaatgggc aggtagccgg     5880

atcaagcgta tgcagccgcc gcattgcatc agccatgatg gatactttct cggcaggagc     5940

aaggtgagat gacaggagat cctgccccgg cacttcgccc aatagcagcc agtcccttcc     6000

cgcttcagtg acaacgtcga gcacagctgc gcaaggaacg cccgtcgtgg ccagccacga     6060

tagccgcgct gcctcgtctt gcagttcatt cagggcaccg gacaggtcgg tcttgacaaa     6120

aagaaccggg cgcccctgcg ctgacagccg gaacacggcg gcatcagagc agccgattgt     6180

ctgttgtgcc cagtcatagc cgaatagcct ctccacccaa gcggccggag aacctgcgtg     6240

caatccatct tgttcaatca taatattatt gaagcattta tcagggttcg tctcgtcccg     6300

gtctcctccc atgcatg                                                    6317


<210>  74
<211>  1107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  74

Met Gly Pro Ala Met Ser Arg Gln Thr Thr Ser Val Gly Ser Ser Cys 
1               5                   10                  15      


Leu Asp Leu Trp Arg Glu Lys Asn Asp Arg Leu Val Arg Gln Ala Lys 
            20                  25                  30          


Val Ala Gln Asn Ser Gly Leu Thr Leu Arg Arg Gln Gln Leu Ala Gln 
        35                  40                  45              


Asp Ala Leu Glu Gly Leu Arg Gly Leu Leu His Ser Leu Gln Gly Leu 
    50                  55                  60                  


Pro Ala Ala Val Pro Val Leu Pro Leu Glu Leu Thr Val Thr Cys Asn 
65                  70                  75                  80  


Phe Ile Ile Leu Arg Ala Ser Leu Ala Gln Gly Phe Thr Glu Asp Gln 
                85                  90                  95      


Ala Gln Asp Ile Gln Arg Ser Leu Glu Arg Val Leu Glu Thr Gln Glu 
            100                 105                 110         


Gln Gln Gly Pro Arg Leu Glu Gln Gly Leu Arg Glu Leu Trp Asp Ser 
        115                 120                 125             


Val Leu Arg Ala Ser Cys Leu Leu Pro Glu Leu Leu Ser Ala Leu His 
    130                 135                 140                 


Arg Leu Val Gly Leu Gln Ala Ala Leu Trp Leu Ser Ala Asp Arg Leu 
145                 150                 155                 160 


Gly Asp Leu Ala Leu Leu Leu Glu Thr Leu Asn Gly Ser Gln Ser Gly 
                165                 170                 175     


Ala Ser Lys Asp Leu Leu Leu Leu Leu Lys Thr Trp Ser Pro Pro Ala 
            180                 185                 190         


Glu Glu Leu Asp Ala Pro Leu Thr Leu Gln Asp Ala Gln Gly Leu Lys 
        195                 200                 205             


Asp Val Leu Leu Thr Ala Phe Ala Tyr Arg Gln Gly Leu Gln Glu Leu 
    210                 215                 220                 


Ile Thr Gly Asn Pro Asp Lys Ala Leu Ser Ser Leu His Glu Ala Ala 
225                 230                 235                 240 


Ser Gly Leu Cys Pro Arg Pro Val Leu Val Gln Val Tyr Thr Ala Leu 
                245                 250                 255     


Gly Ser Cys His Arg Lys Met Gly Asn Pro Gln Arg Ala Leu Leu Tyr 
            260                 265                 270         


Leu Val Ala Ala Leu Lys Glu Gly Ser Ala Trp Gly Pro Pro Leu Leu 
        275                 280                 285             


Glu Ala Ser Arg Leu Tyr Gln Gln Leu Gly Asp Thr Thr Ala Glu Leu 
    290                 295                 300                 


Glu Ser Leu Glu Leu Leu Val Glu Ala Leu Asn Val Pro Cys Ser Ser 
305                 310                 315                 320 


Lys Ala Pro Gln Phe Leu Ile Glu Val Glu Leu Leu Leu Pro Pro Pro 
                325                 330                 335     


Asp Leu Ala Ser Pro Leu His Cys Gly Thr Gln Ser Gln Thr Lys His 
            340                 345                 350         


Ile Leu Ala Ser Arg Cys Leu Gln Thr Gly Arg Ala Gly Asp Ala Ala 
        355                 360                 365             


Glu His Tyr Leu Asp Leu Leu Ala Leu Leu Leu Asp Ser Ser Glu Pro 
    370                 375                 380                 


Arg Phe Ser Pro Pro Pro Ser Pro Pro Gly Pro Cys Met Pro Glu Val 
385                 390                 395                 400 


Phe Leu Glu Ala Ala Val Ala Leu Ile Gln Ala Gly Arg Ala Gln Asp 
                405                 410                 415     


Ala Leu Thr Leu Cys Glu Glu Leu Leu Ser Arg Thr Ser Ser Leu Leu 
            420                 425                 430         


Pro Lys Met Ser Arg Leu Trp Glu Asp Ala Arg Lys Gly Thr Lys Glu 
        435                 440                 445             


Leu Pro Tyr Cys Pro Leu Trp Val Ser Ala Thr His Leu Leu Gln Gly 
    450                 455                 460                 


Gln Ala Trp Val Gln Leu Gly Ala Gln Lys Val Ala Ile Ser Glu Phe 
465                 470                 475                 480 


Ser Arg Cys Leu Glu Leu Leu Phe Arg Ala Thr Pro Glu Glu Lys Glu 
                485                 490                 495     


Gln Gly Ala Ala Phe Asn Cys Glu Gln Gly Cys Lys Ser Asp Ala Ala 
            500                 505                 510         


Leu Gln Gln Leu Arg Ala Ala Ala Leu Ile Ser Arg Gly Leu Glu Trp 
        515                 520                 525             


Val Ala Ser Gly Gln Asp Thr Lys Ala Leu Gln Asp Phe Leu Leu Ser 
    530                 535                 540                 


Val Gln Met Cys Pro Gly Asn Arg Asp Thr Tyr Phe His Leu Leu Gln 
545                 550                 555                 560 


Thr Leu Lys Arg Leu Asp Arg Arg Asp Glu Ala Thr Ala Leu Trp Trp 
                565                 570                 575     


Arg Leu Glu Ala Gln Thr Lys Gly Ser His Glu Asp Ala Leu Trp Ser 
            580                 585                 590         


Leu Pro Leu Tyr Leu Glu Ser Tyr Leu Ser Trp Ile Arg Pro Ser Asp 
        595                 600                 605             


Arg Asp Ala Phe Leu Glu Glu Phe Arg Thr Ser Leu Pro Lys Ser Cys 
    610                 615                 620                 


Asp Leu Asn Val Ile Asp Gly Gly Gly Gly Ser Asp Pro Lys Lys Lys 
625                 630                 635                 640 


Arg Lys Val Asp Pro Lys Lys Lys Arg Lys Val Asp Pro Lys Lys Lys 
                645                 650                 655     


Arg Lys Val Gly Ser Thr Gly Ser Arg Asn Asp Gly Gly Gly Gly Ser 
            660                 665                 670         


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Arg Ala Gly Ile Leu 
        675                 680                 685             


Pro Pro Lys Lys Lys Arg Lys Val Ser Arg Gly Arg Ser Arg Leu Leu 
    690                 695                 700                 


Glu Asp Phe Arg Asn Asn Arg Tyr Pro Asn Leu Gln Leu Arg Glu Ile 
705                 710                 715                 720 


Ala Gly His Ile Met Glu Phe Ser Gln Asp Gln His Gly Ser Arg Phe 
                725                 730                 735     


Ile Gln Leu Lys Leu Glu Arg Ala Thr Pro Ala Glu Arg Gln Leu Val 
            740                 745                 750         


Phe Asn Glu Ile Leu Gln Ala Ala Tyr Gln Leu Met Val Asp Val Phe 
        755                 760                 765             


Gly Asn Tyr Val Ile Gln Lys Phe Phe Glu Phe Gly Ser Leu Glu Gln 
    770                 775                 780                 


Lys Leu Ala Leu Ala Glu Arg Ile Arg Gly His Val Leu Ser Leu Ala 
785                 790                 795                 800 


Leu Gln Met Tyr Gly Ser Arg Val Ile Glu Lys Ala Leu Glu Phe Ile 
                805                 810                 815     


Pro Ser Asp Gln Gln Asn Glu Met Val Arg Glu Leu Asp Gly His Val 
            820                 825                 830         


Leu Lys Cys Val Lys Asp Gln Asn Gly Asn His Val Val Gln Lys Cys 
        835                 840                 845             


Ile Glu Cys Val Gln Pro Gln Ser Leu Gln Phe Ile Ile Asp Ala Phe 
    850                 855                 860                 


Lys Gly Gln Val Phe Ala Leu Ser Thr His Pro Tyr Gly Cys Arg Val 
865                 870                 875                 880 


Ile Gln Arg Ile Leu Glu His Cys Leu Pro Asp Gln Thr Leu Pro Ile 
                885                 890                 895     


Leu Glu Glu Leu His Gln His Thr Glu Gln Leu Val Gln Asp Gln Tyr 
            900                 905                 910         


Gly Asn Tyr Val Ile Gln His Val Leu Glu His Gly Arg Pro Glu Asp 
        915                 920                 925             


Lys Ser Lys Ile Val Ala Glu Ile Arg Gly Asn Val Leu Val Leu Ser 
    930                 935                 940                 


Gln His Lys Phe Ala Ser Asn Val Val Glu Lys Cys Val Thr His Ala 
945                 950                 955                 960 


Ser Arg Thr Glu Arg Ala Val Leu Ile Asp Glu Val Cys Thr Met Asn 
                965                 970                 975     


Asp Gly Pro His Ser Ala Leu Tyr Thr Met Met Lys Asp Gln Tyr Ala 
            980                 985                 990         


Asn Tyr Val Val Gln Lys Met Ile  Asp Val Ala Glu Pro  Gly Gln Arg 
        995                 1000                 1005             


Lys Ile  Val Met His Lys Ile  Arg Pro His Ile Ala  Thr Leu Arg 
    1010                 1015                 1020             


Lys Tyr  Thr Tyr Gly Lys His  Ile Leu Ala Lys Leu  Glu Lys Tyr 
    1025                 1030                 1035             


Tyr Met  Lys Asn Gly Val Asp  Leu Gly Asp Pro Lys  Lys Lys Arg 
    1040                 1045                 1050             


Lys Val  Asp Pro Lys Lys Lys  Arg Lys Val Gly Gly  Arg Gly Gly 
    1055                 1060                 1065             


Gly Gly  Ser Gly Gly Gly Gly  Ser Gly Gly Gly Gly  Ser Gly Pro 
    1070                 1075                 1080             


Ala Met  Asp Tyr Lys Asp His  Asp Gly Asp Tyr Lys  Asp His Asp 
    1085                 1090                 1095             


Ile Asp  Tyr Lys Asp Asp Asp  Asp Lys 
    1100                 1105         


<210>  75
<211>  6305
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide

<400>  75
tcaatattgg ccattagcca tattattcat tggttatata gcataaatca atattggcta       60

ttggccattg catacgttgt atctatatca taatatgtac atttatattg gctcatgtcc      120

aatatgaccg ccatgttggc attgattatt gactagttat taatagtaat caattacggg      180

gtcattagtt catagcccat atatggagtt ccgcgttaca taacttacgg taaatggccc      240

gcctggctga ccgcccaacg acccccgccc attgacgtca ataatgacgt atgttcccat      300

agtaacgcca atagggactt tccattgacg tcaatgggtg gagtatttac ggtaaactgc      360

ccacttggca gtacatcaag tgtatcatat gccaagtccg ccccctattg acgtcaatga      420

cggtaaatgg cccgcctggc attatgccca gtacatgacc ttacgggact ttcctacttg      480

gcagtacatc tacgtattag tcatcgctat taccatggtg atgcggtttt ggcagtacac      540

caatgggcgt ggatagcggt ttgactcacg gggatttcca agtctccacc ccattgacgt      600

caatgggagt ttgttttggc accaaaatca acgggacttt ccaaaatgtc gtaataaccc      660

cgccccgttg acgcaaatgg gcggtaggcg tgtacggtgg gaggtctata taagcagagg      720

tcgtttagtg aaccgtcaga tcactagtag ctttattgcg gtagtttatc acagttaaat      780

tgctaacgca gtcagtgctc gactgatcac aggtaagtat caaggttaca agacaggttt      840

aaggaggcca atagaaactg ggcttgtcga gacagagaag attcttgcgt ttctgatagg      900

cacctattgg tcttactgac atccactttg cctttctctc cacagggaaa aaacaattga      960

caagtttgta caaaaaagca ggctccgaat tcaccggtgc cgccaccatg gactacaagg     1020

atcacgacgg tgactataag gatcatgaca tcgactataa ggacgatgac gataagatcg     1080

atggcggagg cggatctgat ccaaaaaaga agagaaaggt agatccaaaa aagaagagaa     1140

aggtagatcc aaaaaagaag agaaaggtag gatctaccgg atctagaaac gatggtggtg     1200

gtggaagcgg gggtgggggc agcggtggag ggggaagcgg gcgcgccggg atcctccccc     1260

ccaagaaaaa gaggaaggta tctagaggcc gcagccgcct tttggaagat tttcgaaaca     1320

accggtaccc caatttacaa ctgcgggaga ttgctggaca tataatggaa ttttcccaag     1380

accagcatgg gtccagattc attcagctga aactggagcg tgccacacca gctgagcgcc     1440

agcttgtctt caatgaaatc ctccaggctg cctaccaact catggtggat gtgtttggta     1500

attacgtcat tcagaagttc tttgaatttg gcagtcttga acagaagctg gctttggcag     1560

aacggattcg aggccacgtc ctgtcattgg cactacagat gtatggcagc cgtgttatcg     1620

agaaagctct tgagtttatt ccttcagacc agcagaatga gatggttcgg gaactagatg     1680

gccatgtctt gaagtgtgtg aaagatcaga atggcaatca cgtggttcag aaatgcattg     1740

aatgtgtaca gccccagtct ttgcaattta tcatcgacgc gtttaaggga caggtatttg     1800

ccttatccac acatccttat ggctgccgag tgattcagag aatcctggag cactgtctcc     1860

ctgaccagac actccctatt ttagaggagc ttcaccagca cacagagcag ctggtacagg     1920

atcaatatgg aaattatgta atccaacatg tactggagca cggtcgtcct gaggataaaa     1980

gcaaaattgt agcagaaatc cgaggcaatg tacttgtatt gagtcagcac aaatttgcaa     2040

gcaatgttgt ggagaagtgt gttactcacg cctcacgtac ggagcgcgct gtgctcatcg     2100

acgaggtgtg caccatgaac gacggtcccc acagtgcctt atacaccatg atgaaggacc     2160

agtatgccaa ctacgtggtc cagaagatga ttgacgtggc ggagccaggc cagcggaaga     2220

tcgtcatgca taagatccgg ccccacatcg caactcttcg taagtacacc tatggcaagc     2280

acattctggc caagctggag aagtactaca tgaagaacgg tgttgactta ggggacccaa     2340

agaagaagcg caaagtggat cctaaaaaga aaagaaaggt aggcggccgc gggggaggcg     2400

gttccggtgg cggcggaagc ggaggtggag gatcagggcc ggccatgtcc cgccagacca     2460

cctctgtggg ctccagctgc ctggacctgt ggagggaaaa gaatgaccgg ctcgttcgac     2520

aggccaaggt ggctcagaac tccggtctga ctctgaggcg acagcagttg gctcaggatg     2580

cactggaagg gctcagaggg ctcctccata gtctgcaagg gctccctgca gctgttcctg     2640

ttcttccctt ggagctgact gtcacctgca acttcattat cctgagggca agcttggccc     2700

agggtttcac agaggatcag gcccaggata tccagcggag cctagagaga gtgctggaga     2760

cacaggagca gcaggggccc aggttggaac aggggctcag ggagctgtgg gactctgtcc     2820

ttcgtgcttc ctgccttctg ccggagctgc tgtctgccct gcaccgcctg gttggcctgc     2880

aggctgccct ctggttgagt gctgaccgtc ttggggacct ggccttgtta ctagagaccc     2940

tgaatggcag ccagagtgga gcctctaagg atctgctgtt acttctgaaa acttggagtc     3000

ccccagctga ggaattagat gctccattga ccctgcagga tgcccaggga ttgaaggatg     3060

tcctcctgac agcatttgcc taccgccaag gtctccagga gctgatcaca gggaacccag     3120

acaaggcact aagcagcctt catgaagcgg cctcaggcct gtgtccacgg cctgtgttgg     3180

tccaggtgta cacagcactg gggtcctgtc accgtaagat gggaaatcca cagagagcac     3240

tgttgtactt ggttgcagcc ctgaaagagg gatcagcctg gggtcctcca cttctggagg     3300

cctctaggct ctatcagcaa ctgggggaca caacagcaga gctggagagt ctggagctgc     3360

tagttgaggc cttgaatgtc ccatgcagtt ccaaagcccc gcagtttctc attgaggtag     3420

aattactact gccaccacct gacctagcct caccccttca ttgtggcact cagagccaga     3480

ccaagcacat actagcaagc aggtgcctac agacggggag ggcaggagac gctgcagagc     3540

attacttgga cctgctggcc ctgttgctgg atagctcgga gccaaggttc tccccacccc     3600

cctcccctcc agggccctgt atgcctgagg tgtttttgga ggcagcggta gcactgatcc     3660

aggcaggcag agcccaagat gccttgactc tatgtgagga gttgctcagc cgcacatcat     3720

ctctgctacc caagatgtcc cggctgtggg aagatgccag aaaaggaacc aaggaactgc     3780

catactgccc actctgggtc tctgccaccc acctgcttca gggccaggcc tgggttcaac     3840

tgggtgccca aaaagtggca attagtgaat ttagcaggtg cctcgagctg ctcttccggg     3900

ccacacctga ggaaaaagaa caaggggcag ctttcaactg tgagcaggga tgtaagtcag     3960

atgcggcact gcagcagctt cgggcagccg ccctaattag tcgtggactg gaatgggtag     4020

ccagcggcca ggataccaaa gccttacagg acttcctcct cagtgtgcag atgtgcccag     4080

gtaatcgaga cacttacttt cacctgcttc agactctgaa gaggctagat cggagggatg     4140

aggccactgc actctggtgg aggctggagg cccaaactaa ggggtcacat gaagatgctc     4200

tgtggtctct ccccctgtac ctagaaagct atttgagctg gatccgtccc tctgatcgtg     4260

acgccttcct tgaagaattt cggacatctc tgccaaagtc ttgtgacctg aacgtttgat     4320

taattaagaa ttcgacccag ctttcttgta caaagtggtt gatatccagc acagtggcgg     4380

ccgctcgagt ctagagggcc cgcggttcga aggtaagcct atccctaacc ctctcctcgg     4440

tctcgattct acgcgtaccg gttagcaatt gttttttcga tgagtttgga caaaccacaa     4500

ctagaatgca gtgaaaaaaa tgctttattt gtgaaatttg tgatgctatt gctttatttg     4560

taaccattat aagctgcaat aaacaagtta acaacaacaa ttgcattcat tttatgtttc     4620

aggttcaggg ggaggtgtgg gaggtttttt aaagcaagta aaacctctac aaatgtggta     4680

cttaagaggg ggagaccaaa gggcgagacg ttaaggcctc acgtgacatg tgagcaaaag     4740

gccagcaaaa ggccaggaac cgtaaaaagg ccgcgttgct ggcgtttttc cataggctcc     4800

gcccccctga cgagcatcac aaaaatcgac gctcaagtca gaggtggcga aacccgacag     4860

gactataaag ataccaggcg tttccccctg gaagctccct cgtgcgctct cctgttccga     4920

ccctgccgct taccggatac ctgtccgcct ttctcccttc gggaagcgtg gcgctttctc     4980

atagctcacg ctgtaggtat ctcagttcgg tgtaggtcgt tcgctccaag ctgggctgtg     5040

tgcacgaacc ccccgttcag cccgaccgct gcgccttatc cggtaactat cgtcttgagt     5100

ccaacccggt aagacacgac ttatcgccac tggcagcagc cactggtaac aggattagca     5160

gagcgaggta tgtaggcggt gctacagagt tcttgaagtg gtggcctaac tacggctaca     5220

ctagaaggac agtatttggt atctgcgctc tgctgaagcc agttaccttc ggaaaaagag     5280

ttggtagctc ttgatccggc aaacaaacca cgctggtagc ggtggttttt ttgtttgcaa     5340

gcagcagatt acgcgcagaa aaaaaggatc tcaagaagat cctttgatct tttctacggg     5400

gtctgacgct cagtggaacg aaaactcacg ttaagggatt ttggtcatgc cgtctcagaa     5460

gaactcgtca agaaggcgat agaaggcgat gcgctgcgaa tcgggagcgg cgataccgta     5520

aagcacgagg aagcggtcag cccattcgcc gccaagctct tcagcaatat cacgggtagc     5580

caacgctatg tcctgatagc ggtccgccac acccagccgg ccacagtcga tgaatccaga     5640

aaagcggcca ttttccacca tgatattcgg caagcaggca tcgccatggg tcacgacgag     5700

atcctcgccg tcgggcatgc tcgccttgag cctggcgaac agttcggctg gcgcgagccc     5760

ctgatgctct tcgtccagat catcctgatc gacaagaccg gcttccatcc gagtacgtgc     5820

tcgctcgatg cgatgtttcg cttggtggtc gaatgggcag gtagccggat caagcgtatg     5880

cagccgccgc attgcatcag ccatgatgga tactttctcg gcaggagcaa ggtgagatga     5940

caggagatcc tgccccggca cttcgcccaa tagcagccag tcccttcccg cttcagtgac     6000

aacgtcgagc acagctgcgc aaggaacgcc cgtcgtggcc agccacgata gccgcgctgc     6060

ctcgtcttgc agttcattca gggcaccgga caggtcggtc ttgacaaaaa gaaccgggcg     6120

cccctgcgct gacagccgga acacggcggc atcagagcag ccgattgtct gttgtgccca     6180

gtcatagccg aatagcctct ccacccaagc ggccggagaa cctgcgtgca atccatcttg     6240

ttcaatcata atattattga agcatttatc agggttcgtc tcgtcccggt ctcctcccat     6300

gcatg                                                                 6305


<210>  76
<211>  1103
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  76

Met Asp Tyr Lys Asp His Asp Gly Asp Tyr Lys Asp His Asp Ile Asp 
1               5                   10                  15      


Tyr Lys Asp Asp Asp Asp Lys Ile Asp Gly Gly Gly Gly Ser Asp Pro 
            20                  25                  30          


Lys Lys Lys Arg Lys Val Asp Pro Lys Lys Lys Arg Lys Val Asp Pro 
        35                  40                  45              


Lys Lys Lys Arg Lys Val Gly Ser Thr Gly Ser Arg Asn Asp Gly Gly 
    50                  55                  60                  


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Arg Ala 
65                  70                  75                  80  


Gly Ile Leu Pro Pro Lys Lys Lys Arg Lys Val Ser Arg Gly Arg Ser 
                85                  90                  95      


Arg Leu Leu Glu Asp Phe Arg Asn Asn Arg Tyr Pro Asn Leu Gln Leu 
            100                 105                 110         


Arg Glu Ile Ala Gly His Ile Met Glu Phe Ser Gln Asp Gln His Gly 
        115                 120                 125             


Ser Arg Phe Ile Gln Leu Lys Leu Glu Arg Ala Thr Pro Ala Glu Arg 
    130                 135                 140                 


Gln Leu Val Phe Asn Glu Ile Leu Gln Ala Ala Tyr Gln Leu Met Val 
145                 150                 155                 160 


Asp Val Phe Gly Asn Tyr Val Ile Gln Lys Phe Phe Glu Phe Gly Ser 
                165                 170                 175     


Leu Glu Gln Lys Leu Ala Leu Ala Glu Arg Ile Arg Gly His Val Leu 
            180                 185                 190         


Ser Leu Ala Leu Gln Met Tyr Gly Ser Arg Val Ile Glu Lys Ala Leu 
        195                 200                 205             


Glu Phe Ile Pro Ser Asp Gln Gln Asn Glu Met Val Arg Glu Leu Asp 
    210                 215                 220                 


Gly His Val Leu Lys Cys Val Lys Asp Gln Asn Gly Asn His Val Val 
225                 230                 235                 240 


Gln Lys Cys Ile Glu Cys Val Gln Pro Gln Ser Leu Gln Phe Ile Ile 
                245                 250                 255     


Asp Ala Phe Lys Gly Gln Val Phe Ala Leu Ser Thr His Pro Tyr Gly 
            260                 265                 270         


Cys Arg Val Ile Gln Arg Ile Leu Glu His Cys Leu Pro Asp Gln Thr 
        275                 280                 285             


Leu Pro Ile Leu Glu Glu Leu His Gln His Thr Glu Gln Leu Val Gln 
    290                 295                 300                 


Asp Gln Tyr Gly Asn Tyr Val Ile Gln His Val Leu Glu His Gly Arg 
305                 310                 315                 320 


Pro Glu Asp Lys Ser Lys Ile Val Ala Glu Ile Arg Gly Asn Val Leu 
                325                 330                 335     


Val Leu Ser Gln His Lys Phe Ala Ser Asn Val Val Glu Lys Cys Val 
            340                 345                 350         


Thr His Ala Ser Arg Thr Glu Arg Ala Val Leu Ile Asp Glu Val Cys 
        355                 360                 365             


Thr Met Asn Asp Gly Pro His Ser Ala Leu Tyr Thr Met Met Lys Asp 
    370                 375                 380                 


Gln Tyr Ala Asn Tyr Val Val Gln Lys Met Ile Asp Val Ala Glu Pro 
385                 390                 395                 400 


Gly Gln Arg Lys Ile Val Met His Lys Ile Arg Pro His Ile Ala Thr 
                405                 410                 415     


Leu Arg Lys Tyr Thr Tyr Gly Lys His Ile Leu Ala Lys Leu Glu Lys 
            420                 425                 430         


Tyr Tyr Met Lys Asn Gly Val Asp Leu Gly Asp Pro Lys Lys Lys Arg 
        435                 440                 445             


Lys Val Asp Pro Lys Lys Lys Arg Lys Val Gly Gly Arg Gly Gly Gly 
    450                 455                 460                 


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Pro Ala Met 
465                 470                 475                 480 


Ser Arg Gln Thr Thr Ser Val Gly Ser Ser Cys Leu Asp Leu Trp Arg 
                485                 490                 495     


Glu Lys Asn Asp Arg Leu Val Arg Gln Ala Lys Val Ala Gln Asn Ser 
            500                 505                 510         


Gly Leu Thr Leu Arg Arg Gln Gln Leu Ala Gln Asp Ala Leu Glu Gly 
        515                 520                 525             


Leu Arg Gly Leu Leu His Ser Leu Gln Gly Leu Pro Ala Ala Val Pro 
    530                 535                 540                 


Val Leu Pro Leu Glu Leu Thr Val Thr Cys Asn Phe Ile Ile Leu Arg 
545                 550                 555                 560 


Ala Ser Leu Ala Gln Gly Phe Thr Glu Asp Gln Ala Gln Asp Ile Gln 
                565                 570                 575     


Arg Ser Leu Glu Arg Val Leu Glu Thr Gln Glu Gln Gln Gly Pro Arg 
            580                 585                 590         


Leu Glu Gln Gly Leu Arg Glu Leu Trp Asp Ser Val Leu Arg Ala Ser 
        595                 600                 605             


Cys Leu Leu Pro Glu Leu Leu Ser Ala Leu His Arg Leu Val Gly Leu 
    610                 615                 620                 


Gln Ala Ala Leu Trp Leu Ser Ala Asp Arg Leu Gly Asp Leu Ala Leu 
625                 630                 635                 640 


Leu Leu Glu Thr Leu Asn Gly Ser Gln Ser Gly Ala Ser Lys Asp Leu 
                645                 650                 655     


Leu Leu Leu Leu Lys Thr Trp Ser Pro Pro Ala Glu Glu Leu Asp Ala 
            660                 665                 670         


Pro Leu Thr Leu Gln Asp Ala Gln Gly Leu Lys Asp Val Leu Leu Thr 
        675                 680                 685             


Ala Phe Ala Tyr Arg Gln Gly Leu Gln Glu Leu Ile Thr Gly Asn Pro 
    690                 695                 700                 


Asp Lys Ala Leu Ser Ser Leu His Glu Ala Ala Ser Gly Leu Cys Pro 
705                 710                 715                 720 


Arg Pro Val Leu Val Gln Val Tyr Thr Ala Leu Gly Ser Cys His Arg 
                725                 730                 735     


Lys Met Gly Asn Pro Gln Arg Ala Leu Leu Tyr Leu Val Ala Ala Leu 
            740                 745                 750         


Lys Glu Gly Ser Ala Trp Gly Pro Pro Leu Leu Glu Ala Ser Arg Leu 
        755                 760                 765             


Tyr Gln Gln Leu Gly Asp Thr Thr Ala Glu Leu Glu Ser Leu Glu Leu 
    770                 775                 780                 


Leu Val Glu Ala Leu Asn Val Pro Cys Ser Ser Lys Ala Pro Gln Phe 
785                 790                 795                 800 


Leu Ile Glu Val Glu Leu Leu Leu Pro Pro Pro Asp Leu Ala Ser Pro 
                805                 810                 815     


Leu His Cys Gly Thr Gln Ser Gln Thr Lys His Ile Leu Ala Ser Arg 
            820                 825                 830         


Cys Leu Gln Thr Gly Arg Ala Gly Asp Ala Ala Glu His Tyr Leu Asp 
        835                 840                 845             


Leu Leu Ala Leu Leu Leu Asp Ser Ser Glu Pro Arg Phe Ser Pro Pro 
    850                 855                 860                 


Pro Ser Pro Pro Gly Pro Cys Met Pro Glu Val Phe Leu Glu Ala Ala 
865                 870                 875                 880 


Val Ala Leu Ile Gln Ala Gly Arg Ala Gln Asp Ala Leu Thr Leu Cys 
                885                 890                 895     


Glu Glu Leu Leu Ser Arg Thr Ser Ser Leu Leu Pro Lys Met Ser Arg 
            900                 905                 910         


Leu Trp Glu Asp Ala Arg Lys Gly Thr Lys Glu Leu Pro Tyr Cys Pro 
        915                 920                 925             


Leu Trp Val Ser Ala Thr His Leu Leu Gln Gly Gln Ala Trp Val Gln 
    930                 935                 940                 


Leu Gly Ala Gln Lys Val Ala Ile Ser Glu Phe Ser Arg Cys Leu Glu 
945                 950                 955                 960 


Leu Leu Phe Arg Ala Thr Pro Glu Glu Lys Glu Gln Gly Ala Ala Phe 
                965                 970                 975     


Asn Cys Glu Gln Gly Cys Lys Ser Asp Ala Ala Leu Gln Gln Leu Arg 
            980                 985                 990         


Ala Ala Ala Leu Ile Ser Arg Gly  Leu Glu Trp Val Ala  Ser Gly Gln 
        995                 1000                 1005             


Asp Thr  Lys Ala Leu Gln Asp  Phe Leu Leu Ser Val  Gln Met Cys 
    1010                 1015                 1020             


Pro Gly  Asn Arg Asp Thr Tyr  Phe His Leu Leu Gln  Thr Leu Lys 
    1025                 1030                 1035             


Arg Leu  Asp Arg Arg Asp Glu  Ala Thr Ala Leu Trp  Trp Arg Leu 
    1040                 1045                 1050             


Glu Ala  Gln Thr Lys Gly Ser  His Glu Asp Ala Leu  Trp Ser Leu 
    1055                 1060                 1065             


Pro Leu  Tyr Leu Glu Ser Tyr  Leu Ser Trp Ile Arg  Pro Ser Asp 
    1070                 1075                 1080             


Arg Asp  Ala Phe Leu Glu Glu  Phe Arg Thr Ser Leu  Pro Lys Ser 
    1085                 1090                 1095             


Cys Asp  Leu Asn Val 
    1100             


<210>  77
<211>  10520
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide

<400>  77
tcaatattgg ccattagcca tattattcat tggttatata gcataaatca atattggcta       60

ttggccattg catacgttgt atctatatca taatatgtac atttatattg gctcatgtcc      120

aatatgaccg ccatgttggc attgattatt gactagttat taatagtaat caattacggg      180

gtcattagtt catagcccat atatggagtt ccgcgttaca taacttacgg taaatggccc      240

gcctggctga ccgcccaacg acccccgccc attgacgtca ataatgacgt atgttcccat      300

agtaacgcca atagggactt tccattgacg tcaatgggtg gagtatttac ggtaaactgc      360

ccacttggca gtacatcaag tgtatcatat gccaagtccg ccccctattg acgtcaatga      420

cggtaaatgg cccgcctggc attatgccca gtacatgacc ttacgggact ttcctacttg      480

gcagtacatc tacgtattag tcatcgctat taccatggtg atgcggtttt ggcagtacac      540

caatgggcgt ggatagcggt ttgactcacg gggatttcca agtctccacc ccattgacgt      600

caatgggagt ttgttttggc accaaaatca acgggacttt ccaaaatgtc gtaataaccc      660

cgccccgttg acgcaaatgg gcggtaggcg tgtacggtgg gaggtctata taagcagagg      720

tcgtttagtg aaccgtcaga tcactagtag ctttattgcg gtagtttatc acagttaaat      780

tgctaacgca gtcagtgctc gactgatcac aggtaagtat caaggttaca agacaggttt      840

aaggaggcca atagaaactg ggcttgtcga gacagagaag attcttgcgt ttctgatagg      900

cacctattgg tcttactgac atccactttg cctttctctc cacagggaaa aaacaattga      960

caagtttgta caaaaaagca ggctccgaat tcaccggtgc cgccaccatg gggccggcca     1020

tgagcggacg gcaaagaacg ctttttcaga cgtggggctc aagtatctcc cgatcatctg     1080

ggactccggg ttgcagctcc ggaactgagc gacctcagag ccctggcagc tccaaggcgc     1140

ctttgccagc agcagcggag gctcagctgg agtcggacga tgatgtgttg cttgtcgcgg     1200

cgtacgaggc tgagcggcag ttgtgtctag agaatggcgg gttctgcacc tccgcgggcg     1260

ccctgtggat ttaccctacc aattgcccag tgcgggacta ccagctgcac atttcccggg     1320

ctgctctgtt ttgcaatacg ctggtgtgtc tgcctaccgg actgggaaag acctttattg     1380

ccgccgtggt catgtacaat ttctaccgct ggttcccttc aggaaaggtg gtcttcatgg     1440

ccccaacgaa acccttggtg acacagcaga tcgaggcttg ctaccaggtg atgggtatcc     1500

cgcaatccca catggccgaa atgacagggt ctacacaagc ttccaccagg aaggaaatat     1560

ggtgcagtaa gagagtgctt tttcttacac ctcaggtcat ggtaaatgac ctttctagag     1620

gagcttgtcc cgctgctgaa ataaagtgtt tagttattga tgaagctcat aaagctctcg     1680

gaaactatgc ttattgccag gttgtaagag aactagtcaa atatacaaat cactttagaa     1740

tcttggctct aagtgccaca ccaggtagtg atataaaggc tgtgcaacaa gttattacta     1800

acctgctaat tgggcagata gagcttcgtt ctgaagattc tccagatatt ttgacatatt     1860

ctcatgaaag aaaagttgaa aagcttattg ttccgcttgg tgaagaactt gcagccatcc     1920

aaaagaccta tatccagatt ttggaatcat ttgctcgttc tttgattcag aggaatgttt     1980

tgatgagaag ggatatccca aatctaacaa aatatcagat aattctggca agagatcagt     2040

ttaggaaaaa cccatctccg aatattgtgg gaatacaaca aggcataatc gagggagagt     2100

ttgctatttg tattagttta tatcatggtt atgaattatt gcagcaaatg ggaatgagat     2160

cattatattt cttcctttgt ggaattatgg atggaactaa agggatgaca cggtcaaaaa     2220

atgaacttgg ccgaaatgaa gacttcatga aactctataa tcatctagag tgtatgtttg     2280

cacgtacacg tagtacttca gcaaatggta tttctgctat ccaacaagga gataaaaata     2340

aaaaatttgt ttatagtcat ccaaagttaa agaaattaga agaagttgta attgaacact     2400

tcaagtcatg gaatgctgaa aacactactg aaaagaaacg tgatgagacc cgagttatga     2460

tcttctcttc atttcgagat agtgttcaag aaattgcaga aatgctttca cagcatcagc     2520

caattattag agtaatgact tttgtcggcc atgcctcagg gaaaagcacg aagggtttta     2580

cccagaagga gcaactggag gtagtgaaac agtttcgtga cggtggttac aacacgctgg     2640

tttctacctg tgtgggtgaa gaaggtttgg atataggaga agttgatctt ataatatgtt     2700

ttgattccca gaagagccca attcgtcttg tacaacgaat gggtagaact ggccgtaaac     2760

gtcaaggcag gatagttatt atcctttctg aaggacgaga ggaacgtatt tataatcaga     2820

gtcagtccaa caaaagaagt atatataaag ctatttcaag taacaggcag gtccttcatt     2880

tttaccaaag aagtccacga atggttcctg atggaatcaa cccaaaatta cacaaaatgt     2940

tcatcacaca tggtgtctat gaaccagaga agccttctcg gaacttgcag cgaaagtcat     3000

ctatcttttc ctatagggat ggaatgaggc aaagtagcct aaagaaagat tggttcttat     3060

cagaagaaga atttaaatta tggaacagac tttatagatt aagggacagt gatgaaatta     3120

aagagataac attgcctcaa gttcagtttt cttctttaca aaatgaggaa aacaaaccag     3180

ctcaagaatc aaccactgga attcatcaac tctctctctc tgaatggaga ctgtggcaag     3240

atcatccttt gcctacacat caagttgatc actcagatcg atgccgccat tttataggcc     3300

ttatgcaaat gatagaggga atgagacacg aagagggaga atgcagctat gaattggaag     3360

ttgaatctta tttacaaatg gaagatgtta cctcaacatt tattgctccc aggaatgaat     3420

ctaataatct tgccagtgac acctttatca ctcacaagaa atcgtcattt ataaagaaca     3480

taaatcaagg cagttcatcc tcagtgatag aatctgatga agaatgtgct gaaattgtta     3540

aacaaactca tatcaaacct actaaaattg tttctttaaa gaaaaaagtg tctaaagaaa     3600

taaaaaaaga tcagcttaaa aaagaaaata atcacggtat tatagattct gtagataatg     3660

acagaaattc cactgttgaa aatatttttc aagaagacct accaaatgat aaaaggacat     3720

cagatacaga tgaaattgct gccacatgta ctattaatga aaatgttatt aaagaaccgt     3780

gtgtgttatt aacagagtgt cagtttacaa ataaatccac tagttcactt gctggaaatg     3840

ttttagattc tggttataac agtttcaatg atgaaaaatc tgtttcatct aacttatttc     3900

ttccattcga agaagagctt tatattgtta gaacagatga ccaattttat aattgtcact     3960

cattgacaaa agaggtacta gctaatgtag agagattttt atcttattct cctccgcctc     4020

tcagtggact ctcagacttg gaatatgaaa ttgctaaggg tactgcactt gagaatttgc     4080

ttttcttacc ctgtgcagag catttacgaa gtgataaatg cacctgtttg ctgtcacatt     4140

cagctgtgaa ttctcaacag aatttagaat tgaattcact taaatgtata aattatccat     4200

ctgaaaaaag ttgcctttat gatataccta atgataatat ttctgatgag ccaagtctct     4260

gtgactgtga tgtacataaa cataatcaaa atgaaaattt agtacctaac aatcgtgttc     4320

aaatacacag aagccctgca cagaatttag ttggagagaa caatcatgat gttgataaca     4380

gtgacctccc agtattgtcc actgatcaag atgaaagttt gctgttattt gaagatgtta     4440

atacagagtt cgacgatgtg agtctttcac ccttgaacag taaaagcgaa tctttacctg     4500

tgtcagacaa aactgctatt agtgaaacgc ctctggtctc tcagttctta atttctgatg     4560

aacttttgtt ggacaataat tctgaactcc aagatcaaat cacccgtgat gctaatagtt     4620

ttaaatctcg tgatcagaga ggtgtacagg aagaaaaagt gaagaatcat gaggatattt     4680

ttgattgctc tagggattta ttttctgtta cctttgattt aggattctgt agtccagatt     4740

ctgatgatga aatattggaa catacatcag atagcaatag acctctagat gatctatatg     4800

gaaggtattt ggaaattaag gagataagtg atgcaaatta tgtttcgaat caagcactaa     4860

taccaagaga tcatagtaaa aattttacta gtggaactgt tattatccca tcaaatgaag     4920

atatgcagaa tccaaattat gtacatttgc cactgagtgc agcaaaaaat gaagaattgt     4980

tatctcctgg ttattctcag ttttctttac cagtgcaaaa aaaagttatg agtacaccac     5040

tctctaaatc aaacacattg aactcatttt ctaagataag aaaggaaata cttaagacac     5100

cagattctag taaggaaaaa gtaaacctac aaagattcaa agaagcattg aattcaactt     5160

ttgattattc agaattttct ctagaaaagt ctaaaagcag tggtccaatg tatctgcata     5220

aatcctgtca ttctgttgaa gatggacaat tattaacaag taacgaaagt gaagatgacg     5280

agattttccg aagaaaagtt aaaagagcaa aaggaaatgt tttaaactct cctgaggatc     5340

agaaaaatag tgaagttgat tctccacttc atgctgtcaa aaagcgcaga tttcctataa     5400

acagatcaga attatcatct agtgatgaga gtgagaattt tcccaaacca tgttcacaat     5460

tagaagactt caaggtttgt aacgggaatg ccagaagagg catcaaagtc ccaaagagac     5520

agagtcactt aaagcatgta gctaggaagt ttttagatga tgaagcagaa ctttctgaag     5580

aagatgcaga atatgtttca tcagatgaaa atgatgagtc agaaaatgaa caagattcct     5640

cattacttga ctttttaaat gatgaaactc aactttcaca ggctataaat gattctgaaa     5700

tgagagctat ttacatgaaa tctttgcgta gtccaatgat gaacaataag tacaaaatga     5760

ttcataagac acataaaaac ataaacattt tctcgcagat tcctgaacaa gatgaaacct     5820

atttagagga tagtttttgt gttgatgaag aggagtcttg caaaggccaa tcaagtgaag     5880

aagaagtttg tgttgatttt aacttaataa ctgatgattg ctttgcaaat agtaaaaagt     5940

ataaaactcg acgtgcagta atgctaaaag aaatgatgga acaaaattgt gcacattcaa     6000

aaaagaaatt atccagaatt attttaccag atgattcaag tgaggaggag aacaatgtaa     6060

atgataaaag agaatctaat attgcggtta acccaagcac tgttaagaag aacaaacaac     6120

aggaccattg tttaaattca gtgccttctg gatcttctgc gcagtccaag gtgcgttcta     6180

ctccaagagt taatccatta gcaaagcaga gcaaacagac atcgctgaat ttaaaggata     6240

caatttccga agtctcagac ttcaaacctc agaatcataa tgaagtccag tctaccacac     6300

cacccttcac tactgttgat tcacagaaag actgtagaaa atttccagtt ccacagaagg     6360

atggtagtgc tttggaggat tctagcactt caggggcatc ctgttccaag tcaagaccac     6420

atttagctgg gacacatact tctcttagac ttccgcagga aggaaaagga acctgtattc     6480

ttgtaggtgg tcatgaaatc acttctggat tagaagtaat ttcttcccta agagcaattc     6540

atgggttgca agtagaagtt tgtcctctta atggctgtga ttacatcgtg agtaatcgca     6600

tggtggtgga aaggaggtct caatctgaga tgttaaatag tgtcaataag aacaagttca     6660

ttgagcagat ccagcacctg cagagtatgt ttgaaagaat atgtgtgatt gtggaaaagg     6720

acagagaaaa aacaggagac acatcaagga tgtttaggag aacaaagagc tatgacagcc     6780

tgctgactac cttaattggc gctggaatcc gaattctttt cagttcctgc caagaagaaa     6840

ccgcagattt gctaaaggaa ctgtctttag tggaacaaag aaagaatgtt ggtattcatg     6900

ttccaacagt ggtgaatagt aataaaagtg aggcactcca gttttattta agtattccca     6960

atataagtta tataactgca ttaaatatgt gtcaccagtt ttcatctgtg aaaaggatgg     7020

ctaacagctc acttcaagaa atctccatgt atgcacaagt aactcatcag aaggctgagg     7080

agatctatag atatattcac tatgtatttg acatacaaat gttaccaaat gatcttaacc     7140

aagatagact gaaatctgat ataaacgatg gcggaggcgg atctgatcca aaaaagaaga     7200

gaaaggtaga tccaaaaaag aagagaaagg tagatccaaa aaagaagaga aaggtaggat     7260

ctaccggatc tagaaacgat ggtggtggtg gaagcggggg tgggggcagc ggtggagggg     7320

gaagcgggcg cgccgggatc ctccccccca agaaaaagag gaaggtatct agaggccgca     7380

gccgcctttt ggaagatttt cgaaacaacc ggtaccccaa tttacaactg cgggagattg     7440

ctggacatat aatggaattt tcccaagacc agcatgggtc cagattcatt cagctgaaac     7500

tggagcgtgc cacaccagct gagcgccagc ttgtcttcaa tgaaatcctc caggctgcct     7560

accaactcat ggtggatgtg tttggtaatt acgtcattca gaagttcttt gaatttggca     7620

gtcttgaaca gaagctggct ttggcagaac ggattcgagg ccacgtcctg tcattggcac     7680

tacagatgta tggcagccgt gttatcgaga aagctcttga gtttattcct tcagaccagc     7740

agaatgagat ggttcgggaa ctagatggcc atgtcttgaa gtgtgtgaaa gatcagaatg     7800

gcaatcacgt ggttcagaaa tgcattgaat gtgtacagcc ccagtctttg caatttatca     7860

tcgacgcgtt taagggacag gtatttgcct tatccacaca tccttatggc tgccgagtga     7920

ttcagagaat cctggagcac tgtctccctg accagacact ccctatttta gaggagcttc     7980

accagcacac agagcagctg gtacaggatc aatatggaaa ttatgtaatc caacatgtac     8040

tggagcacgg tcgtcctgag gataaaagca aaattgtagc agaaatccga ggcaatgtac     8100

ttgtattgag tcagcacaaa tttgcaagca atgttgtgga gaagtgtgtt actcacgcct     8160

cacgtacgga gcgcgctgtg ctcatcgacg aggtgtgcac catgaacgac ggtccccaca     8220

gtgccttata caccatgatg aaggaccagt atgccaacta cgtggtccag aagatgattg     8280

acgtggcgga gccaggccag cggaagatcg tcatgcataa gatccggccc cacatcgcaa     8340

ctcttcgtaa gtacacctat ggcaagcaca ttctggccaa gctggagaag tactacatga     8400

agaacggtgt tgacttaggg gacccaaaga agaagcgcaa agtggatcct aaaaagaaaa     8460

gaaaggtagg cggccgcggg ggaggcggtt ccggtggcgg cggaagcgga ggtggaggat     8520

cagggccggc ctgattaatt aagaattcga cccagctttc ttgtacaaag tggttgatat     8580

ccagcacagt ggcggccgct cgagtctaga gggcccgcgg ttcgaaggta agcctatccc     8640

taaccctctc ctcggtctcg attctacgcg taccggttag caattgtttt ttcgatgagt     8700

ttggacaaac cacaactaga atgcagtgaa aaaaatgctt tatttgtgaa atttgtgatg     8760

ctattgcttt atttgtaacc attataagct gcaataaaca agttaacaac aacaattgca     8820

ttcattttat gtttcaggtt cagggggagg tgtgggaggt tttttaaagc aagtaaaacc     8880

tctacaaatg tggtacttaa gagggggaga ccaaagggcg agacgttaag gcctcacgtg     8940

acatgtgagc aaaaggccag caaaaggcca ggaaccgtaa aaaggccgcg ttgctggcgt     9000

ttttccatag gctccgcccc cctgacgagc atcacaaaaa tcgacgctca agtcagaggt     9060

ggcgaaaccc gacaggacta taaagatacc aggcgtttcc ccctggaagc tccctcgtgc     9120

gctctcctgt tccgaccctg ccgcttaccg gatacctgtc cgcctttctc ccttcgggaa     9180

gcgtggcgct ttctcatagc tcacgctgta ggtatctcag ttcggtgtag gtcgttcgct     9240

ccaagctggg ctgtgtgcac gaaccccccg ttcagcccga ccgctgcgcc ttatccggta     9300

actatcgtct tgagtccaac ccggtaagac acgacttatc gccactggca gcagccactg     9360

gtaacaggat tagcagagcg aggtatgtag gcggtgctac agagttcttg aagtggtggc     9420

ctaactacgg ctacactaga aggacagtat ttggtatctg cgctctgctg aagccagtta     9480

ccttcggaaa aagagttggt agctcttgat ccggcaaaca aaccacgctg gtagcggtgg     9540

tttttttgtt tgcaagcagc agattacgcg cagaaaaaaa ggatctcaag aagatccttt     9600

gatcttttct acggggtctg acgctcagtg gaacgaaaac tcacgttaag ggattttggt     9660

catgccgtct cagaagaact cgtcaagaag gcgatagaag gcgatgcgct gcgaatcggg     9720

agcggcgata ccgtaaagca cgaggaagcg gtcagcccat tcgccgccaa gctcttcagc     9780

aatatcacgg gtagccaacg ctatgtcctg atagcggtcc gccacaccca gccggccaca     9840

gtcgatgaat ccagaaaagc ggccattttc caccatgata ttcggcaagc aggcatcgcc     9900

atgggtcacg acgagatcct cgccgtcggg catgctcgcc ttgagcctgg cgaacagttc     9960

ggctggcgcg agcccctgat gctcttcgtc cagatcatcc tgatcgacaa gaccggcttc    10020

catccgagta cgtgctcgct cgatgcgatg tttcgcttgg tggtcgaatg ggcaggtagc    10080

cggatcaagc gtatgcagcc gccgcattgc atcagccatg atggatactt tctcggcagg    10140

agcaaggtga gatgacagga gatcctgccc cggcacttcg cccaatagca gccagtccct    10200

tcccgcttca gtgacaacgt cgagcacagc tgcgcaagga acgcccgtcg tggccagcca    10260

cgatagccgc gctgcctcgt cttgcagttc attcagggca ccggacaggt cggtcttgac    10320

aaaaagaacc gggcgcccct gcgctgacag ccggaacacg gcggcatcag agcagccgat    10380

tgtctgttgt gcccagtcat agccgaatag cctctccacc caagcggccg gagaacctgc    10440

gtgcaatcca tcttgttcaa tcataatatt attgaagcat ttatcagggt tcgtctcgtc    10500

ccggtctcct cccatgcatg                                                10520


<210>  78
<211>  2508
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  78

Met Gly Pro Ala Met Ser Gly Arg Gln Arg Thr Leu Phe Gln Thr Trp 
1               5                   10                  15      


Gly Ser Ser Ile Ser Arg Ser Ser Gly Thr Pro Gly Cys Ser Ser Gly 
            20                  25                  30          


Thr Glu Arg Pro Gln Ser Pro Gly Ser Ser Lys Ala Pro Leu Pro Ala 
        35                  40                  45              


Ala Ala Glu Ala Gln Leu Glu Ser Asp Asp Asp Val Leu Leu Val Ala 
    50                  55                  60                  


Ala Tyr Glu Ala Glu Arg Gln Leu Cys Leu Glu Asn Gly Gly Phe Cys 
65                  70                  75                  80  


Thr Ser Ala Gly Ala Leu Trp Ile Tyr Pro Thr Asn Cys Pro Val Arg 
                85                  90                  95      


Asp Tyr Gln Leu His Ile Ser Arg Ala Ala Leu Phe Cys Asn Thr Leu 
            100                 105                 110         


Val Cys Leu Pro Thr Gly Leu Gly Lys Thr Phe Ile Ala Ala Val Val 
        115                 120                 125             


Met Tyr Asn Phe Tyr Arg Trp Phe Pro Ser Gly Lys Val Val Phe Met 
    130                 135                 140                 


Ala Pro Thr Lys Pro Leu Val Thr Gln Gln Ile Glu Ala Cys Tyr Gln 
145                 150                 155                 160 


Val Met Gly Ile Pro Gln Ser His Met Ala Glu Met Thr Gly Ser Thr 
                165                 170                 175     


Gln Ala Ser Thr Arg Lys Glu Ile Trp Cys Ser Lys Arg Val Leu Phe 
            180                 185                 190         


Leu Thr Pro Gln Val Met Val Asn Asp Leu Ser Arg Gly Ala Cys Pro 
        195                 200                 205             


Ala Ala Glu Ile Lys Cys Leu Val Ile Asp Glu Ala His Lys Ala Leu 
    210                 215                 220                 


Gly Asn Tyr Ala Tyr Cys Gln Val Val Arg Glu Leu Val Lys Tyr Thr 
225                 230                 235                 240 


Asn His Phe Arg Ile Leu Ala Leu Ser Ala Thr Pro Gly Ser Asp Ile 
                245                 250                 255     


Lys Ala Val Gln Gln Val Ile Thr Asn Leu Leu Ile Gly Gln Ile Glu 
            260                 265                 270         


Leu Arg Ser Glu Asp Ser Pro Asp Ile Leu Thr Tyr Ser His Glu Arg 
        275                 280                 285             


Lys Val Glu Lys Leu Ile Val Pro Leu Gly Glu Glu Leu Ala Ala Ile 
    290                 295                 300                 


Gln Lys Thr Tyr Ile Gln Ile Leu Glu Ser Phe Ala Arg Ser Leu Ile 
305                 310                 315                 320 


Gln Arg Asn Val Leu Met Arg Arg Asp Ile Pro Asn Leu Thr Lys Tyr 
                325                 330                 335     


Gln Ile Ile Leu Ala Arg Asp Gln Phe Arg Lys Asn Pro Ser Pro Asn 
            340                 345                 350         


Ile Val Gly Ile Gln Gln Gly Ile Ile Glu Gly Glu Phe Ala Ile Cys 
        355                 360                 365             


Ile Ser Leu Tyr His Gly Tyr Glu Leu Leu Gln Gln Met Gly Met Arg 
    370                 375                 380                 


Ser Leu Tyr Phe Phe Leu Cys Gly Ile Met Asp Gly Thr Lys Gly Met 
385                 390                 395                 400 


Thr Arg Ser Lys Asn Glu Leu Gly Arg Asn Glu Asp Phe Met Lys Leu 
                405                 410                 415     


Tyr Asn His Leu Glu Cys Met Phe Ala Arg Thr Arg Ser Thr Ser Ala 
            420                 425                 430         


Asn Gly Ile Ser Ala Ile Gln Gln Gly Asp Lys Asn Lys Lys Phe Val 
        435                 440                 445             


Tyr Ser His Pro Lys Leu Lys Lys Leu Glu Glu Val Val Ile Glu His 
    450                 455                 460                 


Phe Lys Ser Trp Asn Ala Glu Asn Thr Thr Glu Lys Lys Arg Asp Glu 
465                 470                 475                 480 


Thr Arg Val Met Ile Phe Ser Ser Phe Arg Asp Ser Val Gln Glu Ile 
                485                 490                 495     


Ala Glu Met Leu Ser Gln His Gln Pro Ile Ile Arg Val Met Thr Phe 
            500                 505                 510         


Val Gly His Ala Ser Gly Lys Ser Thr Lys Gly Phe Thr Gln Lys Glu 
        515                 520                 525             


Gln Leu Glu Val Val Lys Gln Phe Arg Asp Gly Gly Tyr Asn Thr Leu 
    530                 535                 540                 


Val Ser Thr Cys Val Gly Glu Glu Gly Leu Asp Ile Gly Glu Val Asp 
545                 550                 555                 560 


Leu Ile Ile Cys Phe Asp Ser Gln Lys Ser Pro Ile Arg Leu Val Gln 
                565                 570                 575     


Arg Met Gly Arg Thr Gly Arg Lys Arg Gln Gly Arg Ile Val Ile Ile 
            580                 585                 590         


Leu Ser Glu Gly Arg Glu Glu Arg Ile Tyr Asn Gln Ser Gln Ser Asn 
        595                 600                 605             


Lys Arg Ser Ile Tyr Lys Ala Ile Ser Ser Asn Arg Gln Val Leu His 
    610                 615                 620                 


Phe Tyr Gln Arg Ser Pro Arg Met Val Pro Asp Gly Ile Asn Pro Lys 
625                 630                 635                 640 


Leu His Lys Met Phe Ile Thr His Gly Val Tyr Glu Pro Glu Lys Pro 
                645                 650                 655     


Ser Arg Asn Leu Gln Arg Lys Ser Ser Ile Phe Ser Tyr Arg Asp Gly 
            660                 665                 670         


Met Arg Gln Ser Ser Leu Lys Lys Asp Trp Phe Leu Ser Glu Glu Glu 
        675                 680                 685             


Phe Lys Leu Trp Asn Arg Leu Tyr Arg Leu Arg Asp Ser Asp Glu Ile 
    690                 695                 700                 


Lys Glu Ile Thr Leu Pro Gln Val Gln Phe Ser Ser Leu Gln Asn Glu 
705                 710                 715                 720 


Glu Asn Lys Pro Ala Gln Glu Ser Thr Thr Gly Ile His Gln Leu Ser 
                725                 730                 735     


Leu Ser Glu Trp Arg Leu Trp Gln Asp His Pro Leu Pro Thr His Gln 
            740                 745                 750         


Val Asp His Ser Asp Arg Cys Arg His Phe Ile Gly Leu Met Gln Met 
        755                 760                 765             


Ile Glu Gly Met Arg His Glu Glu Gly Glu Cys Ser Tyr Glu Leu Glu 
    770                 775                 780                 


Val Glu Ser Tyr Leu Gln Met Glu Asp Val Thr Ser Thr Phe Ile Ala 
785                 790                 795                 800 


Pro Arg Asn Glu Ser Asn Asn Leu Ala Ser Asp Thr Phe Ile Thr His 
                805                 810                 815     


Lys Lys Ser Ser Phe Ile Lys Asn Ile Asn Gln Gly Ser Ser Ser Ser 
            820                 825                 830         


Val Ile Glu Ser Asp Glu Glu Cys Ala Glu Ile Val Lys Gln Thr His 
        835                 840                 845             


Ile Lys Pro Thr Lys Ile Val Ser Leu Lys Lys Lys Val Ser Lys Glu 
    850                 855                 860                 


Ile Lys Lys Asp Gln Leu Lys Lys Glu Asn Asn His Gly Ile Ile Asp 
865                 870                 875                 880 


Ser Val Asp Asn Asp Arg Asn Ser Thr Val Glu Asn Ile Phe Gln Glu 
                885                 890                 895     


Asp Leu Pro Asn Asp Lys Arg Thr Ser Asp Thr Asp Glu Ile Ala Ala 
            900                 905                 910         


Thr Cys Thr Ile Asn Glu Asn Val Ile Lys Glu Pro Cys Val Leu Leu 
        915                 920                 925             


Thr Glu Cys Gln Phe Thr Asn Lys Ser Thr Ser Ser Leu Ala Gly Asn 
    930                 935                 940                 


Val Leu Asp Ser Gly Tyr Asn Ser Phe Asn Asp Glu Lys Ser Val Ser 
945                 950                 955                 960 


Ser Asn Leu Phe Leu Pro Phe Glu Glu Glu Leu Tyr Ile Val Arg Thr 
                965                 970                 975     


Asp Asp Gln Phe Tyr Asn Cys His Ser Leu Thr Lys Glu Val Leu Ala 
            980                 985                 990         


Asn Val Glu Arg Phe Leu Ser Tyr  Ser Pro Pro Pro Leu  Ser Gly Leu 
        995                 1000                 1005             


Ser Asp  Leu Glu Tyr Glu Ile  Ala Lys Gly Thr Ala  Leu Glu Asn 
    1010                 1015                 1020             


Leu Leu  Phe Leu Pro Cys Ala  Glu His Leu Arg Ser  Asp Lys Cys 
    1025                 1030                 1035             


Thr Cys  Leu Leu Ser His Ser  Ala Val Asn Ser Gln  Gln Asn Leu 
    1040                 1045                 1050             


Glu Leu  Asn Ser Leu Lys Cys  Ile Asn Tyr Pro Ser  Glu Lys Ser 
    1055                 1060                 1065             


Cys Leu  Tyr Asp Ile Pro Asn  Asp Asn Ile Ser Asp  Glu Pro Ser 
    1070                 1075                 1080             


Leu Cys  Asp Cys Asp Val His  Lys His Asn Gln Asn  Glu Asn Leu 
    1085                 1090                 1095             


Val Pro  Asn Asn Arg Val Gln  Ile His Arg Ser Pro  Ala Gln Asn 
    1100                 1105                 1110             


Leu Val  Gly Glu Asn Asn His  Asp Val Asp Asn Ser  Asp Leu Pro 
    1115                 1120                 1125             


Val Leu  Ser Thr Asp Gln Asp  Glu Ser Leu Leu Leu  Phe Glu Asp 
    1130                 1135                 1140             


Val Asn  Thr Glu Phe Asp Asp  Val Ser Leu Ser Pro  Leu Asn Ser 
    1145                 1150                 1155             


Lys Ser  Glu Ser Leu Pro Val  Ser Asp Lys Thr Ala  Ile Ser Glu 
    1160                 1165                 1170             


Thr Pro  Leu Val Ser Gln Phe  Leu Ile Ser Asp Glu  Leu Leu Leu 
    1175                 1180                 1185             


Asp Asn  Asn Ser Glu Leu Gln  Asp Gln Ile Thr Arg  Asp Ala Asn 
    1190                 1195                 1200             


Ser Phe  Lys Ser Arg Asp Gln  Arg Gly Val Gln Glu  Glu Lys Val 
    1205                 1210                 1215             


Lys Asn  His Glu Asp Ile Phe  Asp Cys Ser Arg Asp  Leu Phe Ser 
    1220                 1225                 1230             


Val Thr  Phe Asp Leu Gly Phe  Cys Ser Pro Asp Ser  Asp Asp Glu 
    1235                 1240                 1245             


Ile Leu  Glu His Thr Ser Asp  Ser Asn Arg Pro Leu  Asp Asp Leu 
    1250                 1255                 1260             


Tyr Gly  Arg Tyr Leu Glu Ile  Lys Glu Ile Ser Asp  Ala Asn Tyr 
    1265                 1270                 1275             


Val Ser  Asn Gln Ala Leu Ile  Pro Arg Asp His Ser  Lys Asn Phe 
    1280                 1285                 1290             


Thr Ser  Gly Thr Val Ile Ile  Pro Ser Asn Glu Asp  Met Gln Asn 
    1295                 1300                 1305             


Pro Asn  Tyr Val His Leu Pro  Leu Ser Ala Ala Lys  Asn Glu Glu 
    1310                 1315                 1320             


Leu Leu  Ser Pro Gly Tyr Ser  Gln Phe Ser Leu Pro  Val Gln Lys 
    1325                 1330                 1335             


Lys Val  Met Ser Thr Pro Leu  Ser Lys Ser Asn Thr  Leu Asn Ser 
    1340                 1345                 1350             


Phe Ser  Lys Ile Arg Lys Glu  Ile Leu Lys Thr Pro  Asp Ser Ser 
    1355                 1360                 1365             


Lys Glu  Lys Val Asn Leu Gln  Arg Phe Lys Glu Ala  Leu Asn Ser 
    1370                 1375                 1380             


Thr Phe  Asp Tyr Ser Glu Phe  Ser Leu Glu Lys Ser  Lys Ser Ser 
    1385                 1390                 1395             


Gly Pro  Met Tyr Leu His Lys  Ser Cys His Ser Val  Glu Asp Gly 
    1400                 1405                 1410             


Gln Leu  Leu Thr Ser Asn Glu  Ser Glu Asp Asp Glu  Ile Phe Arg 
    1415                 1420                 1425             


Arg Lys  Val Lys Arg Ala Lys  Gly Asn Val Leu Asn  Ser Pro Glu 
    1430                 1435                 1440             


Asp Gln  Lys Asn Ser Glu Val  Asp Ser Pro Leu His  Ala Val Lys 
    1445                 1450                 1455             


Lys Arg  Arg Phe Pro Ile Asn  Arg Ser Glu Leu Ser  Ser Ser Asp 
    1460                 1465                 1470             


Glu Ser  Glu Asn Phe Pro Lys  Pro Cys Ser Gln Leu  Glu Asp Phe 
    1475                 1480                 1485             


Lys Val  Cys Asn Gly Asn Ala  Arg Arg Gly Ile Lys  Val Pro Lys 
    1490                 1495                 1500             


Arg Gln  Ser His Leu Lys His  Val Ala Arg Lys Phe  Leu Asp Asp 
    1505                 1510                 1515             


Glu Ala  Glu Leu Ser Glu Glu  Asp Ala Glu Tyr Val  Ser Ser Asp 
    1520                 1525                 1530             


Glu Asn  Asp Glu Ser Glu Asn  Glu Gln Asp Ser Ser  Leu Leu Asp 
    1535                 1540                 1545             


Phe Leu  Asn Asp Glu Thr Gln  Leu Ser Gln Ala Ile  Asn Asp Ser 
    1550                 1555                 1560             


Glu Met  Arg Ala Ile Tyr Met  Lys Ser Leu Arg Ser  Pro Met Met 
    1565                 1570                 1575             


Asn Asn  Lys Tyr Lys Met Ile  His Lys Thr His Lys  Asn Ile Asn 
    1580                 1585                 1590             


Ile Phe  Ser Gln Ile Pro Glu  Gln Asp Glu Thr Tyr  Leu Glu Asp 
    1595                 1600                 1605             


Ser Phe  Cys Val Asp Glu Glu  Glu Ser Cys Lys Gly  Gln Ser Ser 
    1610                 1615                 1620             


Glu Glu  Glu Val Cys Val Asp  Phe Asn Leu Ile Thr  Asp Asp Cys 
    1625                 1630                 1635             


Phe Ala  Asn Ser Lys Lys Tyr  Lys Thr Arg Arg Ala  Val Met Leu 
    1640                 1645                 1650             


Lys Glu  Met Met Glu Gln Asn  Cys Ala His Ser Lys  Lys Lys Leu 
    1655                 1660                 1665             


Ser Arg  Ile Ile Leu Pro Asp  Asp Ser Ser Glu Glu  Glu Asn Asn 
    1670                 1675                 1680             


Val Asn  Asp Lys Arg Glu Ser  Asn Ile Ala Val Asn  Pro Ser Thr 
    1685                 1690                 1695             


Val Lys  Lys Asn Lys Gln Gln  Asp His Cys Leu Asn  Ser Val Pro 
    1700                 1705                 1710             


Ser Gly  Ser Ser Ala Gln Ser  Lys Val Arg Ser Thr  Pro Arg Val 
    1715                 1720                 1725             


Asn Pro  Leu Ala Lys Gln Ser  Lys Gln Thr Ser Leu  Asn Leu Lys 
    1730                 1735                 1740             


Asp Thr  Ile Ser Glu Val Ser  Asp Phe Lys Pro Gln  Asn His Asn 
    1745                 1750                 1755             


Glu Val  Gln Ser Thr Thr Pro  Pro Phe Thr Thr Val  Asp Ser Gln 
    1760                 1765                 1770             


Lys Asp  Cys Arg Lys Phe Pro  Val Pro Gln Lys Asp  Gly Ser Ala 
    1775                 1780                 1785             


Leu Glu  Asp Ser Ser Thr Ser  Gly Ala Ser Cys Ser  Lys Ser Arg 
    1790                 1795                 1800             


Pro His  Leu Ala Gly Thr His  Thr Ser Leu Arg Leu  Pro Gln Glu 
    1805                 1810                 1815             


Gly Lys  Gly Thr Cys Ile Leu  Val Gly Gly His Glu  Ile Thr Ser 
    1820                 1825                 1830             


Gly Leu  Glu Val Ile Ser Ser  Leu Arg Ala Ile His  Gly Leu Gln 
    1835                 1840                 1845             


Val Glu  Val Cys Pro Leu Asn  Gly Cys Asp Tyr Ile  Val Ser Asn 
    1850                 1855                 1860             


Arg Met  Val Val Glu Arg Arg  Ser Gln Ser Glu Met  Leu Asn Ser 
    1865                 1870                 1875             


Val Asn  Lys Asn Lys Phe Ile  Glu Gln Ile Gln His  Leu Gln Ser 
    1880                 1885                 1890             


Met Phe  Glu Arg Ile Cys Val  Ile Val Glu Lys Asp  Arg Glu Lys 
    1895                 1900                 1905             


Thr Gly  Asp Thr Ser Arg Met  Phe Arg Arg Thr Lys  Ser Tyr Asp 
    1910                 1915                 1920             


Ser Leu  Leu Thr Thr Leu Ile  Gly Ala Gly Ile Arg  Ile Leu Phe 
    1925                 1930                 1935             


Ser Ser  Cys Gln Glu Glu Thr  Ala Asp Leu Leu Lys  Glu Leu Ser 
    1940                 1945                 1950             


Leu Val  Glu Gln Arg Lys Asn  Val Gly Ile His Val  Pro Thr Val 
    1955                 1960                 1965             


Val Asn  Ser Asn Lys Ser Glu  Ala Leu Gln Phe Tyr  Leu Ser Ile 
    1970                 1975                 1980             


Pro Asn  Ile Ser Tyr Ile Thr  Ala Leu Asn Met Cys  His Gln Phe 
    1985                 1990                 1995             


Ser Ser  Val Lys Arg Met Ala  Asn Ser Ser Leu Gln  Glu Ile Ser 
    2000                 2005                 2010             


Met Tyr  Ala Gln Val Thr His  Gln Lys Ala Glu Glu  Ile Tyr Arg 
    2015                 2020                 2025             


Tyr Ile  His Tyr Val Phe Asp  Ile Gln Met Leu Pro  Asn Asp Leu 
    2030                 2035                 2040             


Asn Gln  Asp Arg Leu Lys Ser  Asp Ile Asn Asp Gly  Gly Gly Gly 
    2045                 2050                 2055             


Ser Asp  Pro Lys Lys Lys Arg  Lys Val Asp Pro Lys  Lys Lys Arg 
    2060                 2065                 2070             


Lys Val  Asp Pro Lys Lys Lys  Arg Lys Val Gly Ser  Thr Gly Ser 
    2075                 2080                 2085             


Arg Asn  Asp Gly Gly Gly Gly  Ser Gly Gly Gly Gly  Ser Gly Gly 
    2090                 2095                 2100             


Gly Gly  Ser Gly Arg Ala Gly  Ile Leu Pro Pro Lys  Lys Lys Arg 
    2105                 2110                 2115             


Lys Val  Ser Arg Gly Arg Ser  Arg Leu Leu Glu Asp  Phe Arg Asn 
    2120                 2125                 2130             


Asn Arg  Tyr Pro Asn Leu Gln  Leu Arg Glu Ile Ala  Gly His Ile 
    2135                 2140                 2145             


Met Glu  Phe Ser Gln Asp Gln  His Gly Ser Arg Phe  Ile Gln Leu 
    2150                 2155                 2160             


Lys Leu  Glu Arg Ala Thr Pro  Ala Glu Arg Gln Leu  Val Phe Asn 
    2165                 2170                 2175             


Glu Ile  Leu Gln Ala Ala Tyr  Gln Leu Met Val Asp  Val Phe Gly 
    2180                 2185                 2190             


Asn Tyr  Val Ile Gln Lys Phe  Phe Glu Phe Gly Ser  Leu Glu Gln 
    2195                 2200                 2205             


Lys Leu  Ala Leu Ala Glu Arg  Ile Arg Gly His Val  Leu Ser Leu 
    2210                 2215                 2220             


Ala Leu  Gln Met Tyr Gly Ser  Arg Val Ile Glu Lys  Ala Leu Glu 
    2225                 2230                 2235             


Phe Ile  Pro Ser Asp Gln Gln  Asn Glu Met Val Arg  Glu Leu Asp 
    2240                 2245                 2250             


Gly His  Val Leu Lys Cys Val  Lys Asp Gln Asn Gly  Asn His Val 
    2255                 2260                 2265             


Val Gln  Lys Cys Ile Glu Cys  Val Gln Pro Gln Ser  Leu Gln Phe 
    2270                 2275                 2280             


Ile Ile  Asp Ala Phe Lys Gly  Gln Val Phe Ala Leu  Ser Thr His 
    2285                 2290                 2295             


Pro Tyr  Gly Cys Arg Val Ile  Gln Arg Ile Leu Glu  His Cys Leu 
    2300                 2305                 2310             


Pro Asp  Gln Thr Leu Pro Ile  Leu Glu Glu Leu His  Gln His Thr 
    2315                 2320                 2325             


Glu Gln  Leu Val Gln Asp Gln  Tyr Gly Asn Tyr Val  Ile Gln His 
    2330                 2335                 2340             


Val Leu  Glu His Gly Arg Pro  Glu Asp Lys Ser Lys  Ile Val Ala 
    2345                 2350                 2355             


Glu Ile  Arg Gly Asn Val Leu  Val Leu Ser Gln His  Lys Phe Ala 
    2360                 2365                 2370             


Ser Asn  Val Val Glu Lys Cys  Val Thr His Ala Ser  Arg Thr Glu 
    2375                 2380                 2385             


Arg Ala  Val Leu Ile Asp Glu  Val Cys Thr Met Asn  Asp Gly Pro 
    2390                 2395                 2400             


His Ser  Ala Leu Tyr Thr Met  Met Lys Asp Gln Tyr  Ala Asn Tyr 
    2405                 2410                 2415             


Val Val  Gln Lys Met Ile Asp  Val Ala Glu Pro Gly  Gln Arg Lys 
    2420                 2425                 2430             


Ile Val  Met His Lys Ile Arg  Pro His Ile Ala Thr  Leu Arg Lys 
    2435                 2440                 2445             


Tyr Thr  Tyr Gly Lys His Ile  Leu Ala Lys Leu Glu  Lys Tyr Tyr 
    2450                 2455                 2460             


Met Lys  Asn Gly Val Asp Leu  Gly Asp Pro Lys Lys  Lys Arg Lys 
    2465                 2470                 2475             


Val Asp  Pro Lys Lys Lys Arg  Lys Val Gly Gly Arg  Gly Gly Gly 
    2480                 2485                 2490             


Gly Ser  Gly Gly Gly Gly Ser  Gly Gly Gly Gly Ser  Gly Pro Ala 
    2495                 2500                 2505             


<210>  79
<211>  10517
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide

<400>  79
tcaatattgg ccattagcca tattattcat tggttatata gcataaatca atattggcta       60

ttggccattg catacgttgt atctatatca taatatgtac atttatattg gctcatgtcc      120

aatatgaccg ccatgttggc attgattatt gactagttat taatagtaat caattacggg      180

gtcattagtt catagcccat atatggagtt ccgcgttaca taacttacgg taaatggccc      240

gcctggctga ccgcccaacg acccccgccc attgacgtca ataatgacgt atgttcccat      300

agtaacgcca atagggactt tccattgacg tcaatgggtg gagtatttac ggtaaactgc      360

ccacttggca gtacatcaag tgtatcatat gccaagtccg ccccctattg acgtcaatga      420

cggtaaatgg cccgcctggc attatgccca gtacatgacc ttacgggact ttcctacttg      480

gcagtacatc tacgtattag tcatcgctat taccatggtg atgcggtttt ggcagtacac      540

caatgggcgt ggatagcggt ttgactcacg gggatttcca agtctccacc ccattgacgt      600

caatgggagt ttgttttggc accaaaatca acgggacttt ccaaaatgtc gtaataaccc      660

cgccccgttg acgcaaatgg gcggtaggcg tgtacggtgg gaggtctata taagcagagg      720

tcgtttagtg aaccgtcaga tcactagtag ctttattgcg gtagtttatc acagttaaat      780

tgctaacgca gtcagtgctc gactgatcac aggtaagtat caaggttaca agacaggttt      840

aaggaggcca atagaaactg ggcttgtcga gacagagaag attcttgcgt ttctgatagg      900

cacctattgg tcttactgac atccactttg cctttctctc cacagggaaa aaacaattga      960

caagtttgta caaaaaagca ggctccgaat tcaccggtgc cgccaccatg atcgatggcg     1020

gaggcggatc tgatccaaaa aagaagagaa aggtagatcc aaaaaagaag agaaaggtag     1080

atccaaaaaa gaagagaaag gtaggatcta ccggatctag aaacgatggt ggtggtggaa     1140

gcgggggtgg gggcagcggt ggagggggaa gcgggcgcgc cgggatcctc ccccccaaga     1200

aaaagaggaa ggtatctaga ggccgcagcc gccttttgga agattttcga aacaaccggt     1260

accccaattt acaactgcgg gagattgctg gacatataat ggaattttcc caagaccagc     1320

atgggtccag attcattcag ctgaaactgg agcgtgccac accagctgag cgccagcttg     1380

tcttcaatga aatcctccag gctgcctacc aactcatggt ggatgtgttt ggtaattacg     1440

tcattcagaa gttctttgaa tttggcagtc ttgaacagaa gctggctttg gcagaacgga     1500

ttcgaggcca cgtcctgtca ttggcactac agatgtatgg cagccgtgtt atcgagaaag     1560

ctcttgagtt tattccttca gaccagcaga atgagatggt tcgggaacta gatggccatg     1620

tcttgaagtg tgtgaaagat cagaatggca atcacgtggt tcagaaatgc attgaatgtg     1680

tacagcccca gtctttgcaa tttatcatcg acgcgtttaa gggacaggta tttgccttat     1740

ccacacatcc ttatggctgc cgagtgattc agagaatcct ggagcactgt ctccctgacc     1800

agacactccc tattttagag gagcttcacc agcacacaga gcagctggta caggatcaat     1860

atggaaatta tgtaatccaa catgtactgg agcacggtcg tcctgaggat aaaagcaaaa     1920

ttgtagcaga aatccgaggc aatgtacttg tattgagtca gcacaaattt gcaagcaatg     1980

ttgtggagaa gtgtgttact cacgcctcac gtacggagcg cgctgtgctc atcgacgagg     2040

tgtgcaccat gaacgacggt ccccacagtg ccttatacac catgatgaag gaccagtatg     2100

ccaactacgt ggtccagaag atgattgacg tggcggagcc aggccagcgg aagatcgtca     2160

tgcataagat ccggccccac atcgcaactc ttcgtaagta cacctatggc aagcacattc     2220

tggccaagct ggagaagtac tacatgaaga acggtgttga cttaggggac ccaaagaaga     2280

agcgcaaagt ggatcctaaa aagaaaagaa aggtaggcgg ccgcggggga ggcggttccg     2340

gtggcggcgg aagcggaggt ggaggatcag ggccggccat gagcggacgg caaagaacgc     2400

tttttcagac gtggggctca agtatctccc gatcatctgg gactccgggt tgcagctccg     2460

gaactgagcg acctcagagc cctggcagct ccaaggcgcc tttgccagca gcagcggagg     2520

ctcagctgga gtcggacgat gatgtgttgc ttgtcgcggc gtacgaggct gagcggcagt     2580

tgtgtctaga gaatggcggg ttctgcacct ccgcgggcgc cctgtggatt taccctacca     2640

attgcccagt gcgggactac cagctgcaca tttcccgggc tgctctgttt tgcaatacgc     2700

tggtgtgtct gcctaccgga ctgggaaaga cctttattgc cgccgtggtc atgtacaatt     2760

tctaccgctg gttcccttca ggaaaggtgg tcttcatggc cccaacgaaa cccttggtga     2820

cacagcagat cgaggcttgc taccaggtga tgggtatccc gcaatcccac atggccgaaa     2880

tgacagggtc tacacaagct tccaccagga aggaaatatg gtgcagtaag agagtgcttt     2940

ttcttacacc tcaggtcatg gtaaatgacc tttctagagg agcttgtccc gctgctgaaa     3000

taaagtgttt agttattgat gaagctcata aagctctcgg aaactatgct tattgccagg     3060

ttgtaagaga actagtcaaa tatacaaatc actttagaat cttggctcta agtgccacac     3120

caggtagtga tataaaggct gtgcaacaag ttattactaa cctgctaatt gggcagatag     3180

agcttcgttc tgaagattct ccagatattt tgacatattc tcatgaaaga aaagttgaaa     3240

agcttattgt tccgcttggt gaagaacttg cagccatcca aaagacctat atccagattt     3300

tggaatcatt tgctcgttct ttgattcaga ggaatgtttt gatgagaagg gatatcccaa     3360

atctaacaaa atatcagata attctggcaa gagatcagtt taggaaaaac ccatctccga     3420

atattgtggg aatacaacaa ggcataatcg agggagagtt tgctatttgt attagtttat     3480

atcatggtta tgaattattg cagcaaatgg gaatgagatc attatatttc ttcctttgtg     3540

gaattatgga tggaactaaa gggatgacac ggtcaaaaaa tgaacttggc cgaaatgaag     3600

acttcatgaa actctataat catctagagt gtatgtttgc acgtacacgt agtacttcag     3660

caaatggtat ttctgctatc caacaaggag ataaaaataa aaaatttgtt tatagtcatc     3720

caaagttaaa gaaattagaa gaagttgtaa ttgaacactt caagtcatgg aatgctgaaa     3780

acactactga aaagaaacgt gatgagaccc gagttatgat cttctcttca tttcgagata     3840

gtgttcaaga aattgcagaa atgctttcac agcatcagcc aattattaga gtaatgactt     3900

ttgtcggcca tgcctcaggg aaaagcacga agggttttac ccagaaggag caactggagg     3960

tagtgaaaca gtttcgtgac ggtggttaca acacgctggt ttctacctgt gtgggtgaag     4020

aaggtttgga tataggagaa gttgatctta taatatgttt tgattcccag aagagcccaa     4080

ttcgtcttgt acaacgaatg ggtagaactg gccgtaaacg tcaaggcagg atagttatta     4140

tcctttctga aggacgagag gaacgtattt ataatcagag tcagtccaac aaaagaagta     4200

tatataaagc tatttcaagt aacaggcagg tccttcattt ttaccaaaga agtccacgaa     4260

tggttcctga tggaatcaac ccaaaattac acaaaatgtt catcacacat ggtgtctatg     4320

aaccagagaa gccttctcgg aacttgcagc gaaagtcatc tatcttttcc tatagggatg     4380

gaatgaggca aagtagccta aagaaagatt ggttcttatc agaagaagaa tttaaattat     4440

ggaacagact ttatagatta agggacagtg atgaaattaa agagataaca ttgcctcaag     4500

ttcagttttc ttctttacaa aatgaggaaa acaaaccagc tcaagaatca accactggaa     4560

ttcatcaact ctctctctct gaatggagac tgtggcaaga tcatcctttg cctacacatc     4620

aagttgatca ctcagatcga tgccgccatt ttataggcct tatgcaaatg atagagggaa     4680

tgagacacga agagggagaa tgcagctatg aattggaagt tgaatcttat ttacaaatgg     4740

aagatgttac ctcaacattt attgctccca ggaatgaatc taataatctt gccagtgaca     4800

cctttatcac tcacaagaaa tcgtcattta taaagaacat aaatcaaggc agttcatcct     4860

cagtgataga atctgatgaa gaatgtgctg aaattgttaa acaaactcat atcaaaccta     4920

ctaaaattgt ttctttaaag aaaaaagtgt ctaaagaaat aaaaaaagat cagcttaaaa     4980

aagaaaataa tcacggtatt atagattctg tagataatga cagaaattcc actgttgaaa     5040

atatttttca agaagaccta ccaaatgata aaaggacatc agatacagat gaaattgctg     5100

ccacatgtac tattaatgaa aatgttatta aagaaccgtg tgtgttatta acagagtgtc     5160

agtttacaaa taaatccact agttcacttg ctggaaatgt tttagattct ggttataaca     5220

gtttcaatga tgaaaaatct gtttcatcta acttatttct tccattcgaa gaagagcttt     5280

atattgttag aacagatgac caattttata attgtcactc attgacaaaa gaggtactag     5340

ctaatgtaga gagattttta tcttattctc ctccgcctct cagtggactc tcagacttgg     5400

aatatgaaat tgctaagggt actgcacttg agaatttgct tttcttaccc tgtgcagagc     5460

atttacgaag tgataaatgc acctgtttgc tgtcacattc agctgtgaat tctcaacaga     5520

atttagaatt gaattcactt aaatgtataa attatccatc tgaaaaaagt tgcctttatg     5580

atatacctaa tgataatatt tctgatgagc caagtctctg tgactgtgat gtacataaac     5640

ataatcaaaa tgaaaattta gtacctaaca atcgtgttca aatacacaga agccctgcac     5700

agaatttagt tggagagaac aatcatgatg ttgataacag tgacctccca gtattgtcca     5760

ctgatcaaga tgaaagtttg ctgttatttg aagatgttaa tacagagttc gacgatgtga     5820

gtctttcacc cttgaacagt aaaagcgaat ctttacctgt gtcagacaaa actgctatta     5880

gtgaaacgcc tctggtctct cagttcttaa tttctgatga acttttgttg gacaataatt     5940

ctgaactcca agatcaaatc acccgtgatg ctaatagttt taaatctcgt gatcagagag     6000

gtgtacagga agaaaaagtg aagaatcatg aggatatttt tgattgctct agggatttat     6060

tttctgttac ctttgattta ggattctgta gtccagattc tgatgatgaa atattggaac     6120

atacatcaga tagcaataga cctctagatg atctatatgg aaggtatttg gaaattaagg     6180

agataagtga tgcaaattat gtttcgaatc aagcactaat accaagagat catagtaaaa     6240

attttactag tggaactgtt attatcccat caaatgaaga tatgcagaat ccaaattatg     6300

tacatttgcc actgagtgca gcaaaaaatg aagaattgtt atctcctggt tattctcagt     6360

tttctttacc agtgcaaaaa aaagttatga gtacaccact ctctaaatca aacacattga     6420

actcattttc taagataaga aaggaaatac ttaagacacc agattctagt aaggaaaaag     6480

taaacctaca aagattcaaa gaagcattga attcaacttt tgattattca gaattttctc     6540

tagaaaagtc taaaagcagt ggtccaatgt atctgcataa atcctgtcat tctgttgaag     6600

atggacaatt attaacaagt aacgaaagtg aagatgacga gattttccga agaaaagtta     6660

aaagagcaaa aggaaatgtt ttaaactctc ctgaggatca gaaaaatagt gaagttgatt     6720

ctccacttca tgctgtcaaa aagcgcagat ttcctataaa cagatcagaa ttatcatcta     6780

gtgatgagag tgagaatttt cccaaaccat gttcacaatt agaagacttc aaggtttgta     6840

acgggaatgc cagaagaggc atcaaagtcc caaagagaca gagtcactta aagcatgtag     6900

ctaggaagtt tttagatgat gaagcagaac tttctgaaga agatgcagaa tatgtttcat     6960

cagatgaaaa tgatgagtca gaaaatgaac aagattcctc attacttgac tttttaaatg     7020

atgaaactca actttcacag gctataaatg attctgaaat gagagctatt tacatgaaat     7080

ctttgcgtag tccaatgatg aacaataagt acaaaatgat tcataagaca cataaaaaca     7140

taaacatttt ctcgcagatt cctgaacaag atgaaaccta tttagaggat agtttttgtg     7200

ttgatgaaga ggagtcttgc aaaggccaat caagtgaaga agaagtttgt gttgatttta     7260

acttaataac tgatgattgc tttgcaaata gtaaaaagta taaaactcga cgtgcagtaa     7320

tgctaaaaga aatgatggaa caaaattgtg cacattcaaa aaagaaatta tccagaatta     7380

ttttaccaga tgattcaagt gaggaggaga acaatgtaaa tgataaaaga gaatctaata     7440

ttgcggttaa cccaagcact gttaagaaga acaaacaaca ggaccattgt ttaaattcag     7500

tgccttctgg atcttctgcg cagtccaagg tgcgttctac tccaagagtt aatccattag     7560

caaagcagag caaacagaca tcgctgaatt taaaggatac aatttccgaa gtctcagact     7620

tcaaacctca gaatcataat gaagtccagt ctaccacacc acccttcact actgttgatt     7680

cacagaaaga ctgtagaaaa tttccagttc cacagaagga tggtagtgct ttggaggatt     7740

ctagcacttc aggggcatcc tgttccaagt caagaccaca tttagctggg acacatactt     7800

ctcttagact tccgcaggaa ggaaaaggaa cctgtattct tgtaggtggt catgaaatca     7860

cttctggatt agaagtaatt tcttccctaa gagcaattca tgggttgcaa gtagaagttt     7920

gtcctcttaa tggctgtgat tacatcgtga gtaatcgcat ggtggtggaa aggaggtctc     7980

aatctgagat gttaaatagt gtcaataaga acaagttcat tgagcagatc cagcacctgc     8040

agagtatgtt tgaaagaata tgtgtgattg tggaaaagga cagagaaaaa acaggagaca     8100

catcaaggat gtttaggaga acaaagagct atgacagcct gctgactacc ttaattggcg     8160

ctggaatccg aattcttttc agttcctgcc aagaagaaac cgcagatttg ctaaaggaac     8220

tgtctttagt ggaacaaaga aagaatgttg gtattcatgt tccaacagtg gtgaatagta     8280

ataaaagtga ggcactccag ttttatttaa gtattcccaa tataagttat ataactgcat     8340

taaatatgtg tcaccagttt tcatctgtga aaaggatggc taacagctca cttcaagaaa     8400

tctccatgta tgcacaagta actcatcaga aggctgagga gatctataga tatattcact     8460

atgtatttga catacaaatg ttaccaaatg atcttaacca agatagactg aaatctgata     8520

taaacgtttg attaattaag aattcgaccc agctttcttg tacaaagtgg ttgatatcca     8580

gcacagtggc ggccgctcga gtctagaggg cccgcggttc gaaggtaagc ctatccctaa     8640

ccctctcctc ggtctcgatt ctacgcgtac cggttagcaa ttgttttttc gatgagtttg     8700

gacaaaccac aactagaatg cagtgaaaaa aatgctttat ttgtgaaatt tgtgatgcta     8760

ttgctttatt tgtaaccatt ataagctgca ataaacaagt taacaacaac aattgcattc     8820

attttatgtt tcaggttcag ggggaggtgt gggaggtttt ttaaagcaag taaaacctct     8880

acaaatgtgg tacttaagag ggggagacca aagggcgaga cgttaaggcc tcacgtgaca     8940

tgtgagcaaa aggccagcaa aaggccagga accgtaaaaa ggccgcgttg ctggcgtttt     9000

tccataggct ccgcccccct gacgagcatc acaaaaatcg acgctcaagt cagaggtggc     9060

gaaacccgac aggactataa agataccagg cgtttccccc tggaagctcc ctcgtgcgct     9120

ctcctgttcc gaccctgccg cttaccggat acctgtccgc ctttctccct tcgggaagcg     9180

tggcgctttc tcatagctca cgctgtaggt atctcagttc ggtgtaggtc gttcgctcca     9240

agctgggctg tgtgcacgaa ccccccgttc agcccgaccg ctgcgcctta tccggtaact     9300

atcgtcttga gtccaacccg gtaagacacg acttatcgcc actggcagca gccactggta     9360

acaggattag cagagcgagg tatgtaggcg gtgctacaga gttcttgaag tggtggccta     9420

actacggcta cactagaagg acagtatttg gtatctgcgc tctgctgaag ccagttacct     9480

tcggaaaaag agttggtagc tcttgatccg gcaaacaaac cacgctggta gcggtggttt     9540

ttttgtttgc aagcagcaga ttacgcgcag aaaaaaagga tctcaagaag atcctttgat     9600

cttttctacg gggtctgacg ctcagtggaa cgaaaactca cgttaaggga ttttggtcat     9660

gccgtctcag aagaactcgt caagaaggcg atagaaggcg atgcgctgcg aatcgggagc     9720

ggcgataccg taaagcacga ggaagcggtc agcccattcg ccgccaagct cttcagcaat     9780

atcacgggta gccaacgcta tgtcctgata gcggtccgcc acacccagcc ggccacagtc     9840

gatgaatcca gaaaagcggc cattttccac catgatattc ggcaagcagg catcgccatg     9900

ggtcacgacg agatcctcgc cgtcgggcat gctcgccttg agcctggcga acagttcggc     9960

tggcgcgagc ccctgatgct cttcgtccag atcatcctga tcgacaagac cggcttccat    10020

ccgagtacgt gctcgctcga tgcgatgttt cgcttggtgg tcgaatgggc aggtagccgg    10080

atcaagcgta tgcagccgcc gcattgcatc agccatgatg gatactttct cggcaggagc    10140

aaggtgagat gacaggagat cctgccccgg cacttcgccc aatagcagcc agtcccttcc    10200

cgcttcagtg acaacgtcga gcacagctgc gcaaggaacg cccgtcgtgg ccagccacga    10260

tagccgcgct gcctcgtctt gcagttcatt cagggcaccg gacaggtcgg tcttgacaaa    10320

aagaaccggg cgcccctgcg ctgacagccg gaacacggcg gcatcagagc agccgattgt    10380

ctgttgtgcc cagtcatagc cgaatagcct ctccacccaa gcggccggag aacctgcgtg    10440

caatccatct tgttcaatca taatattatt gaagcattta tcagggttcg tctcgtcccg    10500

gtctcctccc atgcatg                                                   10517


<210>  80
<211>  2507
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  80

Met Ile Asp Gly Gly Gly Gly Ser Asp Pro Lys Lys Lys Arg Lys Val 
1               5                   10                  15      


Asp Pro Lys Lys Lys Arg Lys Val Asp Pro Lys Lys Lys Arg Lys Val 
            20                  25                  30          


Gly Ser Thr Gly Ser Arg Asn Asp Gly Gly Gly Gly Ser Gly Gly Gly 
        35                  40                  45              


Gly Ser Gly Gly Gly Gly Ser Gly Arg Ala Gly Ile Leu Pro Pro Lys 
    50                  55                  60                  


Lys Lys Arg Lys Val Ser Arg Gly Arg Ser Arg Leu Leu Glu Asp Phe 
65                  70                  75                  80  


Arg Asn Asn Arg Tyr Pro Asn Leu Gln Leu Arg Glu Ile Ala Gly His 
                85                  90                  95      


Ile Met Glu Phe Ser Gln Asp Gln His Gly Ser Arg Phe Ile Gln Leu 
            100                 105                 110         


Lys Leu Glu Arg Ala Thr Pro Ala Glu Arg Gln Leu Val Phe Asn Glu 
        115                 120                 125             


Ile Leu Gln Ala Ala Tyr Gln Leu Met Val Asp Val Phe Gly Asn Tyr 
    130                 135                 140                 


Val Ile Gln Lys Phe Phe Glu Phe Gly Ser Leu Glu Gln Lys Leu Ala 
145                 150                 155                 160 


Leu Ala Glu Arg Ile Arg Gly His Val Leu Ser Leu Ala Leu Gln Met 
                165                 170                 175     


Tyr Gly Ser Arg Val Ile Glu Lys Ala Leu Glu Phe Ile Pro Ser Asp 
            180                 185                 190         


Gln Gln Asn Glu Met Val Arg Glu Leu Asp Gly His Val Leu Lys Cys 
        195                 200                 205             


Val Lys Asp Gln Asn Gly Asn His Val Val Gln Lys Cys Ile Glu Cys 
    210                 215                 220                 


Val Gln Pro Gln Ser Leu Gln Phe Ile Ile Asp Ala Phe Lys Gly Gln 
225                 230                 235                 240 


Val Phe Ala Leu Ser Thr His Pro Tyr Gly Cys Arg Val Ile Gln Arg 
                245                 250                 255     


Ile Leu Glu His Cys Leu Pro Asp Gln Thr Leu Pro Ile Leu Glu Glu 
            260                 265                 270         


Leu His Gln His Thr Glu Gln Leu Val Gln Asp Gln Tyr Gly Asn Tyr 
        275                 280                 285             


Val Ile Gln His Val Leu Glu His Gly Arg Pro Glu Asp Lys Ser Lys 
    290                 295                 300                 


Ile Val Ala Glu Ile Arg Gly Asn Val Leu Val Leu Ser Gln His Lys 
305                 310                 315                 320 


Phe Ala Ser Asn Val Val Glu Lys Cys Val Thr His Ala Ser Arg Thr 
                325                 330                 335     


Glu Arg Ala Val Leu Ile Asp Glu Val Cys Thr Met Asn Asp Gly Pro 
            340                 345                 350         


His Ser Ala Leu Tyr Thr Met Met Lys Asp Gln Tyr Ala Asn Tyr Val 
        355                 360                 365             


Val Gln Lys Met Ile Asp Val Ala Glu Pro Gly Gln Arg Lys Ile Val 
    370                 375                 380                 


Met His Lys Ile Arg Pro His Ile Ala Thr Leu Arg Lys Tyr Thr Tyr 
385                 390                 395                 400 


Gly Lys His Ile Leu Ala Lys Leu Glu Lys Tyr Tyr Met Lys Asn Gly 
                405                 410                 415     


Val Asp Leu Gly Asp Pro Lys Lys Lys Arg Lys Val Asp Pro Lys Lys 
            420                 425                 430         


Lys Arg Lys Val Gly Gly Arg Gly Gly Gly Gly Ser Gly Gly Gly Gly 
        435                 440                 445             


Ser Gly Gly Gly Gly Ser Gly Pro Ala Met Ser Gly Arg Gln Arg Thr 
    450                 455                 460                 


Leu Phe Gln Thr Trp Gly Ser Ser Ile Ser Arg Ser Ser Gly Thr Pro 
465                 470                 475                 480 


Gly Cys Ser Ser Gly Thr Glu Arg Pro Gln Ser Pro Gly Ser Ser Lys 
                485                 490                 495     


Ala Pro Leu Pro Ala Ala Ala Glu Ala Gln Leu Glu Ser Asp Asp Asp 
            500                 505                 510         


Val Leu Leu Val Ala Ala Tyr Glu Ala Glu Arg Gln Leu Cys Leu Glu 
        515                 520                 525             


Asn Gly Gly Phe Cys Thr Ser Ala Gly Ala Leu Trp Ile Tyr Pro Thr 
    530                 535                 540                 


Asn Cys Pro Val Arg Asp Tyr Gln Leu His Ile Ser Arg Ala Ala Leu 
545                 550                 555                 560 


Phe Cys Asn Thr Leu Val Cys Leu Pro Thr Gly Leu Gly Lys Thr Phe 
                565                 570                 575     


Ile Ala Ala Val Val Met Tyr Asn Phe Tyr Arg Trp Phe Pro Ser Gly 
            580                 585                 590         


Lys Val Val Phe Met Ala Pro Thr Lys Pro Leu Val Thr Gln Gln Ile 
        595                 600                 605             


Glu Ala Cys Tyr Gln Val Met Gly Ile Pro Gln Ser His Met Ala Glu 
    610                 615                 620                 


Met Thr Gly Ser Thr Gln Ala Ser Thr Arg Lys Glu Ile Trp Cys Ser 
625                 630                 635                 640 


Lys Arg Val Leu Phe Leu Thr Pro Gln Val Met Val Asn Asp Leu Ser 
                645                 650                 655     


Arg Gly Ala Cys Pro Ala Ala Glu Ile Lys Cys Leu Val Ile Asp Glu 
            660                 665                 670         


Ala His Lys Ala Leu Gly Asn Tyr Ala Tyr Cys Gln Val Val Arg Glu 
        675                 680                 685             


Leu Val Lys Tyr Thr Asn His Phe Arg Ile Leu Ala Leu Ser Ala Thr 
    690                 695                 700                 


Pro Gly Ser Asp Ile Lys Ala Val Gln Gln Val Ile Thr Asn Leu Leu 
705                 710                 715                 720 


Ile Gly Gln Ile Glu Leu Arg Ser Glu Asp Ser Pro Asp Ile Leu Thr 
                725                 730                 735     


Tyr Ser His Glu Arg Lys Val Glu Lys Leu Ile Val Pro Leu Gly Glu 
            740                 745                 750         


Glu Leu Ala Ala Ile Gln Lys Thr Tyr Ile Gln Ile Leu Glu Ser Phe 
        755                 760                 765             


Ala Arg Ser Leu Ile Gln Arg Asn Val Leu Met Arg Arg Asp Ile Pro 
    770                 775                 780                 


Asn Leu Thr Lys Tyr Gln Ile Ile Leu Ala Arg Asp Gln Phe Arg Lys 
785                 790                 795                 800 


Asn Pro Ser Pro Asn Ile Val Gly Ile Gln Gln Gly Ile Ile Glu Gly 
                805                 810                 815     


Glu Phe Ala Ile Cys Ile Ser Leu Tyr His Gly Tyr Glu Leu Leu Gln 
            820                 825                 830         


Gln Met Gly Met Arg Ser Leu Tyr Phe Phe Leu Cys Gly Ile Met Asp 
        835                 840                 845             


Gly Thr Lys Gly Met Thr Arg Ser Lys Asn Glu Leu Gly Arg Asn Glu 
    850                 855                 860                 


Asp Phe Met Lys Leu Tyr Asn His Leu Glu Cys Met Phe Ala Arg Thr 
865                 870                 875                 880 


Arg Ser Thr Ser Ala Asn Gly Ile Ser Ala Ile Gln Gln Gly Asp Lys 
                885                 890                 895     


Asn Lys Lys Phe Val Tyr Ser His Pro Lys Leu Lys Lys Leu Glu Glu 
            900                 905                 910         


Val Val Ile Glu His Phe Lys Ser Trp Asn Ala Glu Asn Thr Thr Glu 
        915                 920                 925             


Lys Lys Arg Asp Glu Thr Arg Val Met Ile Phe Ser Ser Phe Arg Asp 
    930                 935                 940                 


Ser Val Gln Glu Ile Ala Glu Met Leu Ser Gln His Gln Pro Ile Ile 
945                 950                 955                 960 


Arg Val Met Thr Phe Val Gly His Ala Ser Gly Lys Ser Thr Lys Gly 
                965                 970                 975     


Phe Thr Gln Lys Glu Gln Leu Glu Val Val Lys Gln Phe Arg Asp Gly 
            980                 985                 990         


Gly Tyr Asn Thr Leu Val Ser Thr  Cys Val Gly Glu Glu  Gly Leu Asp 
        995                 1000                 1005             


Ile Gly  Glu Val Asp Leu Ile  Ile Cys Phe Asp Ser  Gln Lys Ser 
    1010                 1015                 1020             


Pro Ile  Arg Leu Val Gln Arg  Met Gly Arg Thr Gly  Arg Lys Arg 
    1025                 1030                 1035             


Gln Gly  Arg Ile Val Ile Ile  Leu Ser Glu Gly Arg  Glu Glu Arg 
    1040                 1045                 1050             


Ile Tyr  Asn Gln Ser Gln Ser  Asn Lys Arg Ser Ile  Tyr Lys Ala 
    1055                 1060                 1065             


Ile Ser  Ser Asn Arg Gln Val  Leu His Phe Tyr Gln  Arg Ser Pro 
    1070                 1075                 1080             


Arg Met  Val Pro Asp Gly Ile  Asn Pro Lys Leu His  Lys Met Phe 
    1085                 1090                 1095             


Ile Thr  His Gly Val Tyr Glu  Pro Glu Lys Pro Ser  Arg Asn Leu 
    1100                 1105                 1110             


Gln Arg  Lys Ser Ser Ile Phe  Ser Tyr Arg Asp Gly  Met Arg Gln 
    1115                 1120                 1125             


Ser Ser  Leu Lys Lys Asp Trp  Phe Leu Ser Glu Glu  Glu Phe Lys 
    1130                 1135                 1140             


Leu Trp  Asn Arg Leu Tyr Arg  Leu Arg Asp Ser Asp  Glu Ile Lys 
    1145                 1150                 1155             


Glu Ile  Thr Leu Pro Gln Val  Gln Phe Ser Ser Leu  Gln Asn Glu 
    1160                 1165                 1170             


Glu Asn  Lys Pro Ala Gln Glu  Ser Thr Thr Gly Ile  His Gln Leu 
    1175                 1180                 1185             


Ser Leu  Ser Glu Trp Arg Leu  Trp Gln Asp His Pro  Leu Pro Thr 
    1190                 1195                 1200             


His Gln  Val Asp His Ser Asp  Arg Cys Arg His Phe  Ile Gly Leu 
    1205                 1210                 1215             


Met Gln  Met Ile Glu Gly Met  Arg His Glu Glu Gly  Glu Cys Ser 
    1220                 1225                 1230             


Tyr Glu  Leu Glu Val Glu Ser  Tyr Leu Gln Met Glu  Asp Val Thr 
    1235                 1240                 1245             


Ser Thr  Phe Ile Ala Pro Arg  Asn Glu Ser Asn Asn  Leu Ala Ser 
    1250                 1255                 1260             


Asp Thr  Phe Ile Thr His Lys  Lys Ser Ser Phe Ile  Lys Asn Ile 
    1265                 1270                 1275             


Asn Gln  Gly Ser Ser Ser Ser  Val Ile Glu Ser Asp  Glu Glu Cys 
    1280                 1285                 1290             


Ala Glu  Ile Val Lys Gln Thr  His Ile Lys Pro Thr  Lys Ile Val 
    1295                 1300                 1305             


Ser Leu  Lys Lys Lys Val Ser  Lys Glu Ile Lys Lys  Asp Gln Leu 
    1310                 1315                 1320             


Lys Lys  Glu Asn Asn His Gly  Ile Ile Asp Ser Val  Asp Asn Asp 
    1325                 1330                 1335             


Arg Asn  Ser Thr Val Glu Asn  Ile Phe Gln Glu Asp  Leu Pro Asn 
    1340                 1345                 1350             


Asp Lys  Arg Thr Ser Asp Thr  Asp Glu Ile Ala Ala  Thr Cys Thr 
    1355                 1360                 1365             


Ile Asn  Glu Asn Val Ile Lys  Glu Pro Cys Val Leu  Leu Thr Glu 
    1370                 1375                 1380             


Cys Gln  Phe Thr Asn Lys Ser  Thr Ser Ser Leu Ala  Gly Asn Val 
    1385                 1390                 1395             


Leu Asp  Ser Gly Tyr Asn Ser  Phe Asn Asp Glu Lys  Ser Val Ser 
    1400                 1405                 1410             


Ser Asn  Leu Phe Leu Pro Phe  Glu Glu Glu Leu Tyr  Ile Val Arg 
    1415                 1420                 1425             


Thr Asp  Asp Gln Phe Tyr Asn  Cys His Ser Leu Thr  Lys Glu Val 
    1430                 1435                 1440             


Leu Ala  Asn Val Glu Arg Phe  Leu Ser Tyr Ser Pro  Pro Pro Leu 
    1445                 1450                 1455             


Ser Gly  Leu Ser Asp Leu Glu  Tyr Glu Ile Ala Lys  Gly Thr Ala 
    1460                 1465                 1470             


Leu Glu  Asn Leu Leu Phe Leu  Pro Cys Ala Glu His  Leu Arg Ser 
    1475                 1480                 1485             


Asp Lys  Cys Thr Cys Leu Leu  Ser His Ser Ala Val  Asn Ser Gln 
    1490                 1495                 1500             


Gln Asn  Leu Glu Leu Asn Ser  Leu Lys Cys Ile Asn  Tyr Pro Ser 
    1505                 1510                 1515             


Glu Lys  Ser Cys Leu Tyr Asp  Ile Pro Asn Asp Asn  Ile Ser Asp 
    1520                 1525                 1530             


Glu Pro  Ser Leu Cys Asp Cys  Asp Val His Lys His  Asn Gln Asn 
    1535                 1540                 1545             


Glu Asn  Leu Val Pro Asn Asn  Arg Val Gln Ile His  Arg Ser Pro 
    1550                 1555                 1560             


Ala Gln  Asn Leu Val Gly Glu  Asn Asn His Asp Val  Asp Asn Ser 
    1565                 1570                 1575             


Asp Leu  Pro Val Leu Ser Thr  Asp Gln Asp Glu Ser  Leu Leu Leu 
    1580                 1585                 1590             


Phe Glu  Asp Val Asn Thr Glu  Phe Asp Asp Val Ser  Leu Ser Pro 
    1595                 1600                 1605             


Leu Asn  Ser Lys Ser Glu Ser  Leu Pro Val Ser Asp  Lys Thr Ala 
    1610                 1615                 1620             


Ile Ser  Glu Thr Pro Leu Val  Ser Gln Phe Leu Ile  Ser Asp Glu 
    1625                 1630                 1635             


Leu Leu  Leu Asp Asn Asn Ser  Glu Leu Gln Asp Gln  Ile Thr Arg 
    1640                 1645                 1650             


Asp Ala  Asn Ser Phe Lys Ser  Arg Asp Gln Arg Gly  Val Gln Glu 
    1655                 1660                 1665             


Glu Lys  Val Lys Asn His Glu  Asp Ile Phe Asp Cys  Ser Arg Asp 
    1670                 1675                 1680             


Leu Phe  Ser Val Thr Phe Asp  Leu Gly Phe Cys Ser  Pro Asp Ser 
    1685                 1690                 1695             


Asp Asp  Glu Ile Leu Glu His  Thr Ser Asp Ser Asn  Arg Pro Leu 
    1700                 1705                 1710             


Asp Asp  Leu Tyr Gly Arg Tyr  Leu Glu Ile Lys Glu  Ile Ser Asp 
    1715                 1720                 1725             


Ala Asn  Tyr Val Ser Asn Gln  Ala Leu Ile Pro Arg  Asp His Ser 
    1730                 1735                 1740             


Lys Asn  Phe Thr Ser Gly Thr  Val Ile Ile Pro Ser  Asn Glu Asp 
    1745                 1750                 1755             


Met Gln  Asn Pro Asn Tyr Val  His Leu Pro Leu Ser  Ala Ala Lys 
    1760                 1765                 1770             


Asn Glu  Glu Leu Leu Ser Pro  Gly Tyr Ser Gln Phe  Ser Leu Pro 
    1775                 1780                 1785             


Val Gln  Lys Lys Val Met Ser  Thr Pro Leu Ser Lys  Ser Asn Thr 
    1790                 1795                 1800             


Leu Asn  Ser Phe Ser Lys Ile  Arg Lys Glu Ile Leu  Lys Thr Pro 
    1805                 1810                 1815             


Asp Ser  Ser Lys Glu Lys Val  Asn Leu Gln Arg Phe  Lys Glu Ala 
    1820                 1825                 1830             


Leu Asn  Ser Thr Phe Asp Tyr  Ser Glu Phe Ser Leu  Glu Lys Ser 
    1835                 1840                 1845             


Lys Ser  Ser Gly Pro Met Tyr  Leu His Lys Ser Cys  His Ser Val 
    1850                 1855                 1860             


Glu Asp  Gly Gln Leu Leu Thr  Ser Asn Glu Ser Glu  Asp Asp Glu 
    1865                 1870                 1875             


Ile Phe  Arg Arg Lys Val Lys  Arg Ala Lys Gly Asn  Val Leu Asn 
    1880                 1885                 1890             


Ser Pro  Glu Asp Gln Lys Asn  Ser Glu Val Asp Ser  Pro Leu His 
    1895                 1900                 1905             


Ala Val  Lys Lys Arg Arg Phe  Pro Ile Asn Arg Ser  Glu Leu Ser 
    1910                 1915                 1920             


Ser Ser  Asp Glu Ser Glu Asn  Phe Pro Lys Pro Cys  Ser Gln Leu 
    1925                 1930                 1935             


Glu Asp  Phe Lys Val Cys Asn  Gly Asn Ala Arg Arg  Gly Ile Lys 
    1940                 1945                 1950             


Val Pro  Lys Arg Gln Ser His  Leu Lys His Val Ala  Arg Lys Phe 
    1955                 1960                 1965             


Leu Asp  Asp Glu Ala Glu Leu  Ser Glu Glu Asp Ala  Glu Tyr Val 
    1970                 1975                 1980             


Ser Ser  Asp Glu Asn Asp Glu  Ser Glu Asn Glu Gln  Asp Ser Ser 
    1985                 1990                 1995             


Leu Leu  Asp Phe Leu Asn Asp  Glu Thr Gln Leu Ser  Gln Ala Ile 
    2000                 2005                 2010             


Asn Asp  Ser Glu Met Arg Ala  Ile Tyr Met Lys Ser  Leu Arg Ser 
    2015                 2020                 2025             


Pro Met  Met Asn Asn Lys Tyr  Lys Met Ile His Lys  Thr His Lys 
    2030                 2035                 2040             


Asn Ile  Asn Ile Phe Ser Gln  Ile Pro Glu Gln Asp  Glu Thr Tyr 
    2045                 2050                 2055             


Leu Glu  Asp Ser Phe Cys Val  Asp Glu Glu Glu Ser  Cys Lys Gly 
    2060                 2065                 2070             


Gln Ser  Ser Glu Glu Glu Val  Cys Val Asp Phe Asn  Leu Ile Thr 
    2075                 2080                 2085             


Asp Asp  Cys Phe Ala Asn Ser  Lys Lys Tyr Lys Thr  Arg Arg Ala 
    2090                 2095                 2100             


Val Met  Leu Lys Glu Met Met  Glu Gln Asn Cys Ala  His Ser Lys 
    2105                 2110                 2115             


Lys Lys  Leu Ser Arg Ile Ile  Leu Pro Asp Asp Ser  Ser Glu Glu 
    2120                 2125                 2130             


Glu Asn  Asn Val Asn Asp Lys  Arg Glu Ser Asn Ile  Ala Val Asn 
    2135                 2140                 2145             


Pro Ser  Thr Val Lys Lys Asn  Lys Gln Gln Asp His  Cys Leu Asn 
    2150                 2155                 2160             


Ser Val  Pro Ser Gly Ser Ser  Ala Gln Ser Lys Val  Arg Ser Thr 
    2165                 2170                 2175             


Pro Arg  Val Asn Pro Leu Ala  Lys Gln Ser Lys Gln  Thr Ser Leu 
    2180                 2185                 2190             


Asn Leu  Lys Asp Thr Ile Ser  Glu Val Ser Asp Phe  Lys Pro Gln 
    2195                 2200                 2205             


Asn His  Asn Glu Val Gln Ser  Thr Thr Pro Pro Phe  Thr Thr Val 
    2210                 2215                 2220             


Asp Ser  Gln Lys Asp Cys Arg  Lys Phe Pro Val Pro  Gln Lys Asp 
    2225                 2230                 2235             


Gly Ser  Ala Leu Glu Asp Ser  Ser Thr Ser Gly Ala  Ser Cys Ser 
    2240                 2245                 2250             


Lys Ser  Arg Pro His Leu Ala  Gly Thr His Thr Ser  Leu Arg Leu 
    2255                 2260                 2265             


Pro Gln  Glu Gly Lys Gly Thr  Cys Ile Leu Val Gly  Gly His Glu 
    2270                 2275                 2280             


Ile Thr  Ser Gly Leu Glu Val  Ile Ser Ser Leu Arg  Ala Ile His 
    2285                 2290                 2295             


Gly Leu  Gln Val Glu Val Cys  Pro Leu Asn Gly Cys  Asp Tyr Ile 
    2300                 2305                 2310             


Val Ser  Asn Arg Met Val Val  Glu Arg Arg Ser Gln  Ser Glu Met 
    2315                 2320                 2325             


Leu Asn  Ser Val Asn Lys Asn  Lys Phe Ile Glu Gln  Ile Gln His 
    2330                 2335                 2340             


Leu Gln  Ser Met Phe Glu Arg  Ile Cys Val Ile Val  Glu Lys Asp 
    2345                 2350                 2355             


Arg Glu  Lys Thr Gly Asp Thr  Ser Arg Met Phe Arg  Arg Thr Lys 
    2360                 2365                 2370             


Ser Tyr  Asp Ser Leu Leu Thr  Thr Leu Ile Gly Ala  Gly Ile Arg 
    2375                 2380                 2385             


Ile Leu  Phe Ser Ser Cys Gln  Glu Glu Thr Ala Asp  Leu Leu Lys 
    2390                 2395                 2400             


Glu Leu  Ser Leu Val Glu Gln  Arg Lys Asn Val Gly  Ile His Val 
    2405                 2410                 2415             


Pro Thr  Val Val Asn Ser Asn  Lys Ser Glu Ala Leu  Gln Phe Tyr 
    2420                 2425                 2430             


Leu Ser  Ile Pro Asn Ile Ser  Tyr Ile Thr Ala Leu  Asn Met Cys 
    2435                 2440                 2445             


His Gln  Phe Ser Ser Val Lys  Arg Met Ala Asn Ser  Ser Leu Gln 
    2450                 2455                 2460             


Glu Ile  Ser Met Tyr Ala Gln  Val Thr His Gln Lys  Ala Glu Glu 
    2465                 2470                 2475             


Ile Tyr  Arg Tyr Ile His Tyr  Val Phe Asp Ile Gln  Met Leu Pro 
    2480                 2485                 2490             


Asn Asp  Leu Asn Gln Asp Arg  Leu Lys Ser Asp Ile  Asn Val 
    2495                 2500                 2505         


<210>  81
<211>  3272
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide

<400>  81
ggcgcgccga gggcctattt cccatgattc cttcatattt gcatatacga tacaaggctg       60

ttagagagat aattggaatt aatttgactg taaacacaaa gatattagta caaaatacgt      120

gacgtagaaa gtaataattt cttgggtagt ttgcagtttt aaaattatgt tttaaaatgg      180

actatcatat gcttaccgta acttgaaagt atttcgattt cttggcttta tatatcttgt      240

ggaaaggacg aaacaccgct gaagcactgc acgccatgtt taagagctat gctggaaaca      300

gcatagcaag tttaaataag gctagtccgt tatcaacttg aaaaagtggc accgagtcgg      360

tgccaattgg gtctccagat tgtatgtagc ctgtatgtag cctgtatgta gcctgtatgt      420

agcctgtatg taagatcttt ttttgtttta gagctagaaa tagcaagtta aaataaggct      480

agtccgtagc gcgtgcgcca attctgcaga caaatggcgg cgcgccgcgg ccgcaggaac      540

ccctagtgat ggagttggcc actccctctc tgcgcgctcg ctcgctcact gaggccgggc      600

gaccaaaggt cgcccgacgc ccgggctttg cccgggcggc ctcagtgagc gagcgagcgc      660

gcagctgcct gcaggggcgc ctgatgcggt attttctcct tacgcatctg tgcggtattt      720

cacaccgcat acgtcaaagc aaccatagta cgcgccctgt agcggcgcat taagcgcggc      780

gggtgtggtg gttacgcgca gcgtgaccgc tacacttgcc agcgccctag cgcccgctcc      840

tttcgctttc ttcccttcct ttctcgccac gttcgccggc tttccccgtc aagctctaaa      900

tcgggggctc cctttagggt tccgatttag tgctttacgg cacctcgacc ccaaaaaact      960

tgatttgggt gatggttcac gtagtgggcc atcgccctga tagacggttt ttcgcccttt     1020

gacgttggag tccacgttct ttaatagtgg actcttgttc caaactggaa caacactcaa     1080

ccctatctcg ggctattctt ttgatttata agggattttg ccgatttcgg cctattggtt     1140

aaaaaatgag ctgatttaac aaaaatttaa cgcgaatttt aacaaaatat taacgtttac     1200

aattttatgg tgcactctca gtacaatctg ctctgatgcc gcatagttaa gccagccccg     1260

acacccgcca acacccgctg acgcgccctg acgggcttgt ctgctcccgg catccgctta     1320

cagacaagct gtgaccgtct ccgggagctg catgtgtcag aggttttcac cgtcatcacc     1380

gaaacgcgcg agacgaaagg gcctcgtgat acgcctattt ttataggtta atgtcatgat     1440

aataatggtt tcttagacgt caggtggcac ttttcgggga aatgtgcgcg gaacccctat     1500

ttgtttattt ttctaaatac attcaaatat gtatccgctc atgagacaat aaccctgata     1560

aatgcttcaa taatattgaa aaaggaagag tatgagtatt caacatttcc gtgtcgccct     1620

tattcccttt tttgcggcat tttgccttcc tgtttttgct cacccagaaa cgctggtgaa     1680

agtaaaagat gctgaagatc agttgggtgc acgagtgggt tacatcgaac tggatctcaa     1740

cagcggtaag atccttgaga gttttcgccc cgaagaacgt tttccaatga tgagcacttt     1800

taaagttctg ctatgtggcg cggtattatc ccgtattgac gccgggcaag agcaactcgg     1860

tcgccgcata cactattctc agaatgactt ggttgagtac tcaccagtca cagaaaagca     1920

tcttacggat ggcatgacag taagagaatt atgcagtgct gccataacca tgagtgataa     1980

cactgcggcc aacttacttc tgacaacgat cggaggaccg aaggagctaa ccgctttttt     2040

gcacaacatg ggggatcatg taactcgcct tgatcgttgg gaaccggagc tgaatgaagc     2100

cataccaaac gacgagcgtg acaccacgat gcctgtagca atggcaacaa cgttgcgcaa     2160

actattaact ggcgaactac ttactctagc ttcccggcaa caattaatag actggatgga     2220

ggcggataaa gttgcaggac cacttctgcg ctcggccctt ccggctggct ggtttattgc     2280

tgataaatct ggagccggtg agcgtggaag ccgcggtatc attgcagcac tggggccaga     2340

tggtaagccc tcccgtatcg tagttatcta cacgacgggg agtcaggcaa ctatggatga     2400

acgaaataga cagatcgctg agataggtgc ctcactgatt aagcattggt aactgtcaga     2460

ccaagtttac tcatatatac tttagattga tttaaaactt catttttaat ttaaaaggat     2520

ctaggtgaag atcctttttg ataatctcat gaccaaaatc ccttaacgtg agttttcgtt     2580

ccactgagcg tcagaccccg tagaaaagat caaaggatct tcttgagatc ctttttttct     2640

gcgcgtaatc tgctgcttgc aaacaaaaaa accaccgcta ccagcggtgg tttgtttgcc     2700

ggatcaagag ctaccaactc tttttccgaa ggtaactggc ttcagcagag cgcagatacc     2760

aaatactgtc cttctagtgt agccgtagtt aggccaccac ttcaagaact ctgtagcacc     2820

gcctacatac ctcgctctgc taatcctgtt accagtggct gctgccagtg gcgataagtc     2880

gtgtcttacc gggttggact caagacgata gttaccggat aaggcgcagc ggtcgggctg     2940

aacggggggt tcgtgcacac agcccagctt ggagcgaacg acctacaccg aactgagata     3000

cctacagcgt gagctatgag aaagcgccac gcttcccgaa gggagaaagg cggacaggta     3060

tccggtaagc ggcagggtcg gaacaggaga gcgcacgagg gagcttccag ggggaaacgc     3120

ctggtatctt tatagtcctg tcgggtttcg ccacctctga cttgagcgtc gatttttgtg     3180

atgctcgtca ggggggcgga gcctatggaa aaacgccagc aacgcggcct ttttacggtt     3240

cctggccttt tgctggcctt ttgctcacat gt                                   3272


<210>  82
<211>  187
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide

<400>  82
gcugaagcac ugcacgccau guuuaagagc uaugcuggaa acagcauagc aaguuuaaau       60

aaggcuaguc cguuaucaac uugaaaaagu ggcaccgagu cggugccaau ugggucucca      120

gauuguaugu agccuguaug uagccuguau guagccugua uguagccugu auguaagauc      180

uuuuuuu                                                                187


<210>  83
<211>  8
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide

<400>  83
uguaugua                                                                 8


<210>  84
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide

<400>  84
gctgaagcac tgcacgccat                                                   20


<210>  85
<211>  127
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide

<400>  85
gccacctacg gcaagctgac cctgaagttc atctgcacca ccggcaagct gcccgtgccc       60

tggcccaccc tcgtgaccac cctgacgtac ggcgtgcagt gcttcagccg ctaccccgac      120

cacatga                                                                127


<210>  86
<211>  8759
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide

<400>  86
ctagtcctgc aggtttaaac gaattcgccc tttgctttct ctgaccagca ttctctcccc       60

tgggcctgtg ccgctttctg tctgcagctt gtggcctggg tcacctctac ggctggccca      120

gatccttccc tgccgcctcc ttcaggttcc gtcttcctcc actccctctt ccccttgctc      180

tctgctgtgt tgctgcccaa ggatgctctt tccggagcac ttccttctcg gcgctgcacc      240

acgtgatgtc ctctgagcgg atcctccccg tgtctgggtc ctctccgggc atctctcctc      300

cctcacccaa ccccatgccg tcttcactcg ctgggttccc ttttccttct ccttctgggg      360

cctgtgccat ctctcgtttc ttaggatggc cttctccgac ggatgtctcc cttgcgtccc      420

gcctcccctt cttgtaggcc tgcatcatca ccgtttttct ggacaacccc aaagtacccc      480

gtctccctgg ctttagccac ctctccatcc tcttgctttc tttgcctgga caccccgttc      540

tcctgtggat tcgggtcacc tctcactcct ttcatttggg cagctcccct acccccctta      600

cctctctagt ctgtgctagc tcttccagcc ccctgtcatg gcatcttcca ggggtccgag      660

agctcagcta gtcttcttcc tccaacccgg gcccctatgt ccacttcagg acagcatgtt      720

tgctgcctcc agggatcctg tgtccccgag ctgggaccac cttatattcc cagggccggt      780

taatgtggct ctggttctgg gtacttttat ctgtcccctc caccccacag tggggcaagc      840

ttctgacctc ttctcttcct cccacagggc ctcgagagat ctggcagcgg agagggcaga      900

ggaagtcttc taacatgcgg tgacgtggag gagaatcccg gccctaggct cgagatgacc      960

gagtacaagc ccacggtgcg cctcgccacc cgcgacgacg tccccagggc cgtacgcacc     1020

ctcgccgccg cgttcgccga ctaccccgcc acgcgccaca ccgtcgatcc ggaccgccac     1080

atcgagcggg tcaccgagct gcaagaactc ttcctcacgc gcgtcgggct cgacatcggc     1140

aaggtgtggg tcgcggacga cggcgccgcg gtggcggtct ggaccacgcc ggagagcgtc     1200

gaagcggggg cggtgttcgc cgagatcggc ccgcgcatgg ccgagttgag cggttcccgg     1260

ctggccgcgc agcaacagat ggaaggcctc ctggcgccgc accggcccaa ggagcccgcg     1320

tggttcctgg ccaccgtcgg cgtctcgccc gaccaccagg gcaagggtct gggcagcgcc     1380

gtcgtgctcc ccggagtgga ggcggccgag cgcgccgggg tgcccgcctt cctggagacc     1440

tccgcgcccc gcaacctccc cttctacgag cggctcggct tcaccgtcac cgccgacgtc     1500

gaggtgcccg aaggaccgcg cacctggtgc atgacccgca agcccggtgc ctgatctaga     1560

gggcccgttt aaacccgctg atcagcctcg actgtgcctt ctagttgcca gccatctgtt     1620

gtttgcccct cccccgtgcc ttccttgacc ctggaaggtg ccactcccac tgtcctttcc     1680

taataaaatg aggaaattgc atcgcattgt ctgagtaggt gtcattctat tctggggggt     1740

ggggtggggc aggacagcaa gggggaggat tgggaagaca atagcaggca tgctggggat     1800

gcggtgggct ctatgggtcg actcaatatt ggccattagc catattattc attggttata     1860

tagcataaat caatattggc tattggccat tgcatacgtt gtatctatat cataatatgt     1920

acatttatat tggctcatgt ccaatatgac cgccatgttg gcattgatta ttgactagtt     1980

attaatagta atcaattacg gggtcattag ttcatagccc atatatggag ttccgcgtta     2040

cataacttac ggtaaatggc ccgcctggct gaccgcccaa cgacccccgc ccattgacgt     2100

caataatgac gtatgttccc atagtaacgc caatagggac tttccattga cgtcaatggg     2160

tggagtattt acggtaaact gcccacttgg cagtacatca agtgtatcat atgccaagtc     2220

cgccccctat tgacgtcaat gacggtaaat ggcccgcctg gcattatgcc cagtacatga     2280

ccttacggga ctttcctact tggcagtaca tctacgtatt agtcatcgct attaccatgg     2340

tgatgcggtt ttggcagtac accaatgggc gtggatagcg gtttgactca cggggatttc     2400

caagtctcca ccccattgac gtcaatggga gtttgttttg gcaccaaaat caacgggact     2460

ttccaaaatg tcgtaataac cccgccccgt tgacgcaaat gggcggtagg cgtgtacggt     2520

gggaggtcta tataagcaga ggtcgtttag tgaaccgtca gatcactagt agctttattg     2580

cggtagttta tcacagttaa attgctaacg cagtcagtgc tcgactgatc acaggtaagt     2640

atcaaggtta caagacaggt ttaaggaggc caatagaaac tgggcttgtc gagacagaga     2700

agattcttgc gtttctgata ggcacctatt ggtcttactg acatccactt tgcctttctc     2760

tccacagggt ctagtccagt gtggtggaat tctgcagata tcaacaagtt tgtacaaaaa     2820

agcaggctcc gaattcaccc ggtgccgcca ccatggtgag caagggcgag gagctgttca     2880

ccggggtggt gcccatcctg gtcgagctgg acggcgacgt aaacggccac aagttcagcg     2940

tgtccggcga gggcgagggc gatgccacct acggcaagct gaccctgaag ttcatctgca     3000

ccaccggcaa gctgccggtg ccctggccca ccctcgtgac caccctgacc catggcgtgc     3060

agtgcttcag ccgctacccc gaccacatga agcagcacga cttcttcaag tccgccatgc     3120

ccgaaggcta cgtccaggag cgcaccatct tcttcaagga cgacggcaac tacaagaccc     3180

gcgccgaggt gaagttcgag ggcgacaccc tggtgaaccg catcgagctg aagggcatcg     3240

acttcaagga ggacggcaac atcctggggc acaagctgga gtacaactac aacagccaca     3300

acgtctatat catggccgac aagcagaaga acggcatcaa ggtgaacttc aagatccgcc     3360

acaacatcga ggacggcagc gtgcagctcg ccgaccacta ccagcagaac acccccatcg     3420

gcgacggccc cgtgctgctg cccgacaacc actacctgag cacccagtcc aagctgagca     3480

aagaccccaa cgagaagcgc gatcacatgg tcctgctgga gttcgtgacc gccgccggga     3540

tcactctcgg catggacgag ctgtacaagt aattaattaa gaattcgacc cagctttctt     3600

gtacaaagtg gttgatatcc agcacagtgg cggccgctcg agtctagagg gcccgcggtt     3660

cgaaggtaag cctatcccta accctctcct cggtctcgat tctacgcgta ccggttaggg     3720

gcccgtttaa acccgctgat cagcctcgac tgtgccttct agttgccagc catctgttgt     3780

ttgcccctcc cccgtgcctt ccttgaccct ggaaggtgcc actcccactg tcctttccta     3840

ataaaatgag gaaattgcat cgcattgtct gagtaggtgt cattctattc tggggggtgg     3900

ggtggggcag gacagcaagg gggaggattg ggaagacaat agcaggcatg ctggggatgc     3960

ggtgggctct atggcgtcga cagtactaag ctttactagg gacaggattg gtgacagaaa     4020

agccccatcc ttaggcctcc tccttcctag tctcctgata ttgggtctaa cccccacctc     4080

ctgttaggca gattccttat ctggtgacac acccccattt cctggagcca tctctctcct     4140

tgccagaacc tctaaggttt gcttacgatg gagccagaga ggatcctggg agggagagct     4200

tggcaggggg tgggagggaa gggggggatg cgtgacctgc ccggttctca gtggccaccc     4260

tgcgctaccc tctcccagaa cctgagctgc tctgacgcgg ctgtctggtg cgtttcactg     4320

atcctggtgc tgcagcttcc ttacacttcc caagaggaga agcagtttgg aaaaacaaaa     4380

tcagaataag ttggtcctga gttctaactt tggctcttca cctttctagt ccccaattta     4440

tattgttcct ccgtgcgtca gttttacctg tgagataagg ccagtagcca gccccgtcct     4500

ggcagggctg tggtgaggag gggggtgtcc gtgtggaaaa ctccctttgt gagaatggtg     4560

cgtcctaggt gttcaccagg tcgtggccgc ctctactccc tttctctttc tccatccttc     4620

tttccttaaa gagtccccag tgctatctgg gacatattcc tccgcccaga gcagggtccc     4680

gcttccctaa ggccctgctc tgggcttctg ggtttgagtc cttggcaagc ccaggagagg     4740

cgctcaggct tccctgtccc ccttcctcgt ccaccatctc atgcccctgg ctctcctgcc     4800

ccttccctac aggggttcct ggctctgctc taagggcgaa ttcgcggccg ctaaattcaa     4860

ttcgccctat agtgagtcgt attacaattc actggccgtc gttttacaac gtcgtgactg     4920

ggaaaaccct ggcgttaccc aacttaatcg ccttgcagca catccccctt tcgccagctg     4980

gcgtaatagc gaagaggccc gcaccgatcg cccttcccaa cagttgcgca gcctatacgt     5040

acggcagttt aaggtttaca cctataaaag agagagccgt tatcgtctgt ttgtggatgt     5100

acagagtgat attattgaca cgccggggcg acggatggtg atccccctgg ccagtgcacg     5160

tctgctgtca gataaagtct cccgtgaact ttacccggtg gtgcatatcg gggatgaaag     5220

ctggcgcatg atgaccaccg atatggccag tgtgccggtc tccgttatcg gggaagaagt     5280

ggctgatctc agccaccgcg aaaatgacat caaaaacgcc attaacctga tgttctgggg     5340

aatataaatg tcaggcatga gattatcaaa aaggatcttc acctagatcc ttttcacgta     5400

gaaagccagt ccgcagaaac ggtgctgacc ccggatgaat gtcagctact gggctatctg     5460

gacaagggaa aacgcaagcg caaagagaaa gcaggtagct tgcagtgggc ttacatggcg     5520

atagctagac tgggcggttt tatggacagc aagcgaaccg gaattgccag ctggggcgcc     5580

ctctggtaag gttgggaagc cctgcaaagt aaactggatg gctttcttgc cgccaaggat     5640

ctgatggcgc aggggatcaa gctctgatca agagacagga tgaggatcgt ttcgcatgat     5700

tgaacaagat ggattgcacg caggttctcc ggccgcttgg gtggagaggc tattcggcta     5760

tgactgggca caacagacaa tcggctgctc tgatgccgcc gtgttccggc tgtcagcgca     5820

ggggcgcccg gttctttttg tcaagaccga cctgtccggt gccctgaatg aactgcaaga     5880

cgaggcagcg cggctatcgt ggctggccac gacgggcgtt ccttgcgcag ctgtgctcga     5940

cgttgtcact gaagcgggaa gggactggct gctattgggc gaagtgccgg ggcaggatct     6000

cctgtcatct caccttgctc ctgccgagaa agtatccatc atggctgatg caatgcggcg     6060

gctgcatacg cttgatccgg ctacctgccc attcgaccac caagcgaaac atcgcatcga     6120

gcgagcacgt actcggatgg aagccggtct tgtcgatcag gatgatctgg acgaagagca     6180

tcaggggctc gcgccagccg aactgttcgc caggctcaag gcgagcatgc ccgacggcga     6240

ggatctcgtc gtgacccatg catggcgatg cctgcttgcc gaatatcatg gtggaaaatg     6300

gccgcttttc tggattcatc gactgtggcc ggctgggtgt ggcggaccgc tatcaggaca     6360

tagcgttggc tacccgtgat attgctgaag agcttggcgg cgaatgggct gaccgcttcc     6420

tcgtgcttta cggtatcgcc gctcccgatt cgcagcgcat cgccttctat cgccttcttg     6480

acgagttctt ctgaattatt aacgcttaca atttcctgat gcggtatttt ctccttacgc     6540

atctgtgcgg tatttcacac cgcatcaggt ggcacttttc ggggaaatgt gcgcggaacc     6600

cctatttgtt tatttttcta aatacattca aatatgtatc cgctcatgag attatcaaaa     6660

aggatcttca cctagatcct tttaaattaa aaatgaagtt ttaaatcaat ctaaagtata     6720

tatgagtaaa cttggtctga cagttaccaa tgcttaatca gtgaggcacc tatctcagcg     6780

atctgtctat ttcgttcatc catagttgcc tgactccccg tcgtgtagat aactacgata     6840

cgggagggct taccatctgg ccccagtgct gcaatgatac cgcgagaccc acgctcaccg     6900

gctccagatt tatcagcaat aaaccagcca gccggaaggg ccgagcgcag aagtggtcct     6960

gcaactttat ccgcctccat ccagtctatt aattgttgcc gggaagctag agtaagtagt     7020

tcgccagtta atagtttgcg caacgttgtt gccattgcta caggcatcgt ggtgtcacgc     7080

tcgtcgtttg gtatggcttc attcagctcc ggttcccaac gatcaaggcg agttacatga     7140

tcccccatgt tgtgcaaaaa agcggttagc tccttcggtc ctccgatcgt tgtcagaagt     7200

aagttggccg cagtgttatc actcatggtt atggcagcac tgcataattc tcttactgtc     7260

atgccatccg taagatgctt ttctgtgact ggtgagtact caaccaagtc attctgagaa     7320

tagtgtatgc ggcgaccgag ttgctcttgc ccggcgtcaa tacgggataa taccgcgcca     7380

catagcagaa ctttaaaagt gctcatcatt ggaaaacgtt cttcggggcg aaaactctca     7440

aggatcttac cgctgttgag atccagttcg atgtaaccca ctcgtgcacc caactgatct     7500

tcagcatctt ttactttcac cagcgtttct gggtgagcaa aaacaggaag gcaaaatgcc     7560

gcaaaaaagg gaataagggc gacacggaaa tgttgaatac tcatactctt cctttttcaa     7620

tattattgaa gcatttatca gggttattgt ctcatgacca aaatccctta acgtgagttt     7680

tcgttccact gagcgtcaga ccccgtagaa aagatcaaag gatcttcttg agatcctttt     7740

tttctgcgcg taatctgctg cttgcaaaca aaaaaaccac cgctaccagc ggtggtttgt     7800

ttgccggatc aagagctacc aactcttttt ccgaaggtaa ctggcttcag cagagcgcag     7860

ataccaaata ctgttcttct agtgtagccg tagttaggcc accacttcaa gaactctgta     7920

gcaccgccta catacctcgc tctgctaatc ctgttaccag tggctgctgc cagtggcgat     7980

aagtcgtgtc ttaccgggtt ggactcaaga cgatagttac cggataaggc gcagcggtcg     8040

ggctgaacgg ggggttcgtg cacacagccc agcttggagc gaacgaccta caccgaactg     8100

agatacctac agcgtgagct atgagaaagc gccacgcttc ccgaagggag aaaggcggac     8160

aggtatccgg taagcggcag ggtcggaaca ggagagcgca cgagggagct tccaggggga     8220

aacgcctggt atctttatag tcctgtcggg tttcgccacc tctgacttga gcgtcgattt     8280

ttgtgatgct cgtcaggggg gcggagccta tggaaaaacg ccagcaacgc ggccttttta     8340

cggttcctgg ccttttgctg gccttttgct cacatgttct ttcctgcgtt atcccctgat     8400

tctgtggata accgtattac cgcctttgag tgagctgata ccgctcgccg cagccgaacg     8460

accgagcgca gcgagtcagt gagcgaggaa gcggaagagc gcccaatacg caaaccgcct     8520

ctccccgcgc gttggccgat tcattaatgc agctggcacg acaggtttcc cgactggaaa     8580

gcgggcagtg agcgcaacgc aattaatgtg agttagctca ctcattaggc accccaggct     8640

ttacacttta tgcttccggc tcgtatgttg tgtggaattg tgagcggata acaatttcac     8700

acaggaaaca gctatgacca tgattacgcc aagctcagaa ttaaccctca ctaaaggga      8759


<210>  87
<211>  720
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide

<400>  87
atggtgagca agggcgagga gctgttcacc ggggtggtgc ccatcctggt cgagctggac       60

ggcgacgtaa acggccacaa gttcagcgtg tccggcgagg gcgagggcga tgccacctac      120

ggcaagctga ccctgaagtt catctgcacc accggcaagc tgccggtgcc ctggcccacc      180

ctcgtgacca ccctgaccca tggcgtgcag tgcttcagcc gctaccccga ccacatgaag      240

cagcacgact tcttcaagtc cgccatgccc gaaggctacg tccaggagcg caccatcttc      300

ttcaaggacg acggcaacta caagacccgc gccgaggtga agttcgaggg cgacaccctg      360

gtgaaccgca tcgagctgaa gggcatcgac ttcaaggagg acggcaacat cctggggcac      420

aagctggagt acaactacaa cagccacaac gtctatatca tggccgacaa gcagaagaac      480

ggcatcaagg tgaacttcaa gatccgccac aacatcgagg acggcagcgt gcagctcgcc      540

gaccactacc agcagaacac ccccatcggc gacggccccg tgctgctgcc cgacaaccac      600

tacctgagca cccagtccaa gctgagcaaa gaccccaacg agaagcgcga tcacatggtc      660

ctgctggagt tcgtgaccgc cgccgggatc actctcggca tggacgagct gtacaagtaa      720


<210>  88
<211>  239
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  88

Met Val Ser Lys Gly Glu Glu Leu Phe Thr Gly Val Val Pro Ile Leu 
1               5                   10                  15      


Val Glu Leu Asp Gly Asp Val Asn Gly His Lys Phe Ser Val Ser Gly 
            20                  25                  30          


Glu Gly Glu Gly Asp Ala Thr Tyr Gly Lys Leu Thr Leu Lys Phe Ile 
        35                  40                  45              


Cys Thr Thr Gly Lys Leu Pro Val Pro Trp Pro Thr Leu Val Thr Thr 
    50                  55                  60                  


Leu Thr His Gly Val Gln Cys Phe Ser Arg Tyr Pro Asp His Met Lys 
65                  70                  75                  80  


Gln His Asp Phe Phe Lys Ser Ala Met Pro Glu Gly Tyr Val Gln Glu 
                85                  90                  95      


Arg Thr Ile Phe Phe Lys Asp Asp Gly Asn Tyr Lys Thr Arg Ala Glu 
            100                 105                 110         


Val Lys Phe Glu Gly Asp Thr Leu Val Asn Arg Ile Glu Leu Lys Gly 
        115                 120                 125             


Ile Asp Phe Lys Glu Asp Gly Asn Ile Leu Gly His Lys Leu Glu Tyr 
    130                 135                 140                 


Asn Tyr Asn Ser His Asn Val Tyr Ile Met Ala Asp Lys Gln Lys Asn 
145                 150                 155                 160 


Gly Ile Lys Val Asn Phe Lys Ile Arg His Asn Ile Glu Asp Gly Ser 
                165                 170                 175     


Val Gln Leu Ala Asp His Tyr Gln Gln Asn Thr Pro Ile Gly Asp Gly 
            180                 185                 190         


Pro Val Leu Leu Pro Asp Asn His Tyr Leu Ser Thr Gln Ser Lys Leu 
        195                 200                 205             


Ser Lys Asp Pro Asn Glu Lys Arg Asp His Met Val Leu Leu Glu Phe 
    210                 215                 220                 


Val Thr Ala Ala Gly Ile Thr Leu Gly Met Asp Glu Leu Tyr Lys 
225                 230                 235                 


<210>  89
<211>  37
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide

<400>  89
gttttagagc tagaaatagc aagttaaaat aaggcta                                37


<210>  90
<211>  47
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide

<400>  90
gtttaagagc tatgctggaa acagcatagc aagtttaaat aaggcta                     47


<210>  91
<211>  1435
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  91

Met Ile Asp Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
1               5                   10                  15      


Gly Ser Met Tyr Pro Tyr Asp Val Pro Asp Tyr Ala Ser Pro Lys Lys 
            20                  25                  30          


Lys Arg Lys Val Glu Ala Ser Asp Lys Lys Tyr Ser Ile Gly Leu Asp 
        35                  40                  45              


Ile Gly Thr Asn Ser Val Gly Trp Ala Val Ile Thr Asp Glu Tyr Lys 
    50                  55                  60                  


Val Pro Ser Lys Lys Phe Lys Val Leu Gly Asn Thr Asp Arg His Ser 
65                  70                  75                  80  


Ile Lys Lys Asn Leu Ile Gly Ala Leu Leu Phe Asp Ser Gly Glu Thr 
                85                  90                  95      


Ala Glu Ala Thr Arg Leu Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg 
            100                 105                 110         


Arg Lys Asn Arg Ile Cys Tyr Leu Gln Glu Ile Phe Ser Asn Glu Met 
        115                 120                 125             


Ala Lys Val Asp Asp Ser Phe Phe His Arg Leu Glu Glu Ser Phe Leu 
    130                 135                 140                 


Val Glu Glu Asp Lys Lys His Glu Arg His Pro Ile Phe Gly Asn Ile 
145                 150                 155                 160 


Val Asp Glu Val Ala Tyr His Glu Lys Tyr Pro Thr Ile Tyr His Leu 
                165                 170                 175     


Arg Lys Lys Leu Val Asp Ser Thr Asp Lys Ala Asp Leu Arg Leu Ile 
            180                 185                 190         


Tyr Leu Ala Leu Ala His Met Ile Lys Phe Arg Gly His Phe Leu Ile 
        195                 200                 205             


Glu Gly Asp Leu Asn Pro Asp Asn Ser Asp Val Asp Lys Leu Phe Ile 
    210                 215                 220                 


Gln Leu Val Gln Thr Tyr Asn Gln Leu Phe Glu Glu Asn Pro Ile Asn 
225                 230                 235                 240 


Ala Ser Gly Val Asp Ala Lys Ala Ile Leu Ser Ala Arg Leu Ser Lys 
                245                 250                 255     


Ser Arg Arg Leu Glu Asn Leu Ile Ala Gln Leu Pro Gly Glu Lys Lys 
            260                 265                 270         


Asn Gly Leu Phe Gly Asn Leu Ile Ala Leu Ser Leu Gly Leu Thr Pro 
        275                 280                 285             


Asn Phe Lys Ser Asn Phe Asp Leu Ala Glu Asp Ala Lys Leu Gln Leu 
    290                 295                 300                 


Ser Lys Asp Thr Tyr Asp Asp Asp Leu Asp Asn Leu Leu Ala Gln Ile 
305                 310                 315                 320 


Gly Asp Gln Tyr Ala Asp Leu Phe Leu Ala Ala Lys Asn Leu Ser Asp 
                325                 330                 335     


Ala Ile Leu Leu Ser Asp Ile Leu Arg Val Asn Thr Glu Ile Thr Lys 
            340                 345                 350         


Ala Pro Leu Ser Ala Ser Met Ile Lys Arg Tyr Asp Glu His His Gln 
        355                 360                 365             


Asp Leu Thr Leu Leu Lys Ala Leu Val Arg Gln Gln Leu Pro Glu Lys 
    370                 375                 380                 


Tyr Lys Glu Ile Phe Phe Asp Gln Ser Lys Asn Gly Tyr Ala Gly Tyr 
385                 390                 395                 400 


Ile Asp Gly Gly Ala Ser Gln Glu Glu Phe Tyr Lys Phe Ile Lys Pro 
                405                 410                 415     


Ile Leu Glu Lys Met Asp Gly Thr Glu Glu Leu Leu Val Lys Leu Asn 
            420                 425                 430         


Arg Glu Asp Leu Leu Arg Lys Gln Arg Thr Phe Asp Asn Gly Ser Ile 
        435                 440                 445             


Pro His Gln Ile His Leu Gly Glu Leu His Ala Ile Leu Arg Arg Gln 
    450                 455                 460                 


Glu Asp Phe Tyr Pro Phe Leu Lys Asp Asn Arg Glu Lys Ile Glu Lys 
465                 470                 475                 480 


Ile Leu Thr Phe Arg Ile Pro Tyr Tyr Val Gly Pro Leu Ala Arg Gly 
                485                 490                 495     


Asn Ser Arg Phe Ala Trp Met Thr Arg Lys Ser Glu Glu Thr Ile Thr 
            500                 505                 510         


Pro Trp Asn Phe Glu Glu Val Val Asp Lys Gly Ala Ser Ala Gln Ser 
        515                 520                 525             


Phe Ile Glu Arg Met Thr Asn Phe Asp Lys Asn Leu Pro Asn Glu Lys 
    530                 535                 540                 


Val Leu Pro Lys His Ser Leu Leu Tyr Glu Tyr Phe Thr Val Tyr Asn 
545                 550                 555                 560 


Glu Leu Thr Lys Val Lys Tyr Val Thr Glu Gly Met Arg Lys Pro Ala 
                565                 570                 575     


Phe Leu Ser Gly Glu Gln Lys Lys Ala Ile Val Asp Leu Leu Phe Lys 
            580                 585                 590         


Thr Asn Arg Lys Val Thr Val Lys Gln Leu Lys Glu Asp Tyr Phe Lys 
        595                 600                 605             


Lys Ile Glu Cys Phe Asp Ser Val Glu Ile Ser Gly Val Glu Asp Arg 
    610                 615                 620                 


Phe Asn Ala Ser Leu Gly Thr Tyr His Asp Leu Leu Lys Ile Ile Lys 
625                 630                 635                 640 


Asp Lys Asp Phe Leu Asp Asn Glu Glu Asn Glu Asp Ile Leu Glu Asp 
                645                 650                 655     


Ile Val Leu Thr Leu Thr Leu Phe Glu Asp Arg Glu Met Ile Glu Glu 
            660                 665                 670         


Arg Leu Lys Thr Tyr Ala His Leu Phe Asp Asp Lys Val Met Lys Gln 
        675                 680                 685             


Leu Lys Arg Arg Arg Tyr Thr Gly Trp Gly Arg Leu Ser Arg Lys Leu 
    690                 695                 700                 


Ile Asn Gly Ile Arg Asp Lys Gln Ser Gly Lys Thr Ile Leu Asp Phe 
705                 710                 715                 720 


Leu Lys Ser Asp Gly Phe Ala Asn Arg Asn Phe Met Gln Leu Ile His 
                725                 730                 735     


Asp Asp Ser Leu Thr Phe Lys Glu Asp Ile Gln Lys Ala Gln Val Ser 
            740                 745                 750         


Gly Gln Gly Asp Ser Leu His Glu His Ile Ala Asn Leu Ala Gly Ser 
        755                 760                 765             


Pro Ala Ile Lys Lys Gly Ile Leu Gln Thr Val Lys Val Val Asp Glu 
    770                 775                 780                 


Leu Val Lys Val Met Gly Arg His Lys Pro Glu Asn Ile Val Ile Glu 
785                 790                 795                 800 


Met Ala Arg Glu Asn Gln Thr Thr Gln Lys Gly Gln Lys Asn Ser Arg 
                805                 810                 815     


Glu Arg Met Lys Arg Ile Glu Glu Gly Ile Lys Glu Leu Gly Ser Gln 
            820                 825                 830         


Ile Leu Lys Glu His Pro Val Glu Asn Thr Gln Leu Gln Asn Glu Lys 
        835                 840                 845             


Leu Tyr Leu Tyr Tyr Leu Gln Asn Gly Arg Asp Met Tyr Val Asp Gln 
    850                 855                 860                 


Glu Leu Asp Ile Asn Arg Leu Ser Asp Tyr Asp Val Asp Ala Ile Val 
865                 870                 875                 880 


Pro Gln Ser Phe Leu Lys Asp Asp Ser Ile Asp Asn Lys Val Leu Thr 
                885                 890                 895     


Arg Ser Asp Lys Asn Arg Gly Lys Ser Asp Asn Val Pro Ser Glu Glu 
            900                 905                 910         


Val Val Lys Lys Met Lys Asn Tyr Trp Arg Gln Leu Leu Asn Ala Lys 
        915                 920                 925             


Leu Ile Thr Gln Arg Lys Phe Asp Asn Leu Thr Lys Ala Glu Arg Gly 
    930                 935                 940                 


Gly Leu Ser Glu Leu Asp Lys Ala Gly Phe Ile Lys Arg Gln Leu Val 
945                 950                 955                 960 


Glu Thr Arg Gln Ile Thr Lys His Val Ala Gln Ile Leu Asp Ser Arg 
                965                 970                 975     


Met Asn Thr Lys Tyr Asp Glu Asn Asp Lys Leu Ile Arg Glu Val Lys 
            980                 985                 990         


Val Ile Thr Leu Lys Ser Lys Leu  Val Ser Asp Phe Arg  Lys Asp Phe 
        995                 1000                 1005             


Gln Phe  Tyr Lys Val Arg Glu  Ile Asn Asn Tyr His  His Ala His 
    1010                 1015                 1020             


Asp Ala  Tyr Leu Asn Ala Val  Val Gly Thr Ala Leu  Ile Lys Lys 
    1025                 1030                 1035             


Tyr Pro  Lys Leu Glu Ser Glu  Phe Val Tyr Gly Asp  Tyr Lys Val 
    1040                 1045                 1050             


Tyr Asp  Val Arg Lys Met Ile  Ala Lys Ser Glu Gln  Glu Ile Gly 
    1055                 1060                 1065             


Lys Ala  Thr Ala Lys Tyr Phe  Phe Tyr Ser Asn Ile  Met Asn Phe 
    1070                 1075                 1080             


Phe Lys  Thr Glu Ile Thr Leu  Ala Asn Gly Glu Ile  Arg Lys Arg 
    1085                 1090                 1095             


Pro Leu  Ile Glu Thr Asn Gly  Glu Thr Gly Glu Ile  Val Trp Asp 
    1100                 1105                 1110             


Lys Gly  Arg Asp Phe Ala Thr  Val Arg Lys Val Leu  Ser Met Pro 
    1115                 1120                 1125             


Gln Val  Asn Ile Val Lys Lys  Thr Glu Val Gln Thr  Gly Gly Phe 
    1130                 1135                 1140             


Ser Lys  Glu Ser Ile Leu Pro  Lys Arg Asn Ser Asp  Lys Leu Ile 
    1145                 1150                 1155             


Ala Arg  Lys Lys Asp Trp Asp  Pro Lys Lys Tyr Gly  Gly Phe Asp 
    1160                 1165                 1170             


Ser Pro  Thr Val Ala Tyr Ser  Val Leu Val Val Ala  Lys Val Glu 
    1175                 1180                 1185             


Lys Gly  Lys Ser Lys Lys Leu  Lys Ser Val Lys Glu  Leu Leu Gly 
    1190                 1195                 1200             


Ile Thr  Ile Met Glu Arg Ser  Ser Phe Glu Lys Asn  Pro Ile Asp 
    1205                 1210                 1215             


Phe Leu  Glu Ala Lys Gly Tyr  Lys Glu Val Lys Lys  Asp Leu Ile 
    1220                 1225                 1230             


Ile Lys  Leu Pro Lys Tyr Ser  Leu Phe Glu Leu Glu  Asn Gly Arg 
    1235                 1240                 1245             


Lys Arg  Met Leu Ala Ser Ala  Gly Glu Leu Gln Lys  Gly Asn Glu 
    1250                 1255                 1260             


Leu Ala  Leu Pro Ser Lys Tyr  Val Asn Phe Leu Tyr  Leu Ala Ser 
    1265                 1270                 1275             


His Tyr  Glu Lys Leu Lys Gly  Ser Pro Glu Asp Asn  Glu Gln Lys 
    1280                 1285                 1290             


Gln Leu  Phe Val Glu Gln His  Lys His Tyr Leu Asp  Glu Ile Ile 
    1295                 1300                 1305             


Glu Gln  Ile Ser Glu Phe Ser  Lys Arg Val Ile Leu  Ala Asp Ala 
    1310                 1315                 1320             


Asn Leu  Asp Lys Val Leu Ser  Ala Tyr Asn Lys His  Arg Asp Lys 
    1325                 1330                 1335             


Pro Ile  Arg Glu Gln Ala Glu  Asn Ile Ile His Leu  Phe Thr Leu 
    1340                 1345                 1350             


Thr Asn  Leu Gly Ala Pro Ala  Ala Phe Lys Tyr Phe  Asp Thr Thr 
    1355                 1360                 1365             


Ile Asp  Arg Lys Arg Tyr Thr  Ser Thr Lys Glu Val  Leu Asp Ala 
    1370                 1375                 1380             


Thr Leu  Ile His Gln Ser Ile  Thr Gly Leu Tyr Glu  Thr Arg Ile 
    1385                 1390                 1395             


Asp Leu  Ser Gln Leu Gly Gly  Asp Ser Pro Lys Lys  Lys Arg Lys 
    1400                 1405                 1410             


Val Glu  Ala Ser Gly Gly Gly  Gly Ser Gly Gly Gly  Gly Ser Gly 
    1415                 1420                 1425             


Gly Gly  Gly Ser Gly Pro Ala  
    1430                 1435 


