                         SEQUENCE LISTING

<110>  City of Hope
       Kortylewski, Marcin Tomasz
       Swiderski, Piotr Marek
 
<120>  OLIGONUCLEOTIDE INHIBITORS OF NUCLEAR FACTOR 
       KAPPA-LIGHT-CHAIN-ENHANCER OF ACTIVATED B CELLS AND USES THEREOF

<130>  048440-710001WO

<150>  62/722,728
<151>  2018-08-24

<160>  21    

<170>  PatentIn version 3.5

<210>  1
<211>  26
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5' terminus modified by 
       3-(((3-(((3-(((3-(((3-hydroxypropoxy)oxidophosphoryl)oxy)propoxy)
       oxidophosphoryl)oxy)propoxy)oxidophosphoryl)oxy)propoxy)oxidophos
       phoryl)oxy)propyl

<220>
<221>  misc_feature
<222>  (13)..(14)
<223>  3-(((3-(((3-(((3-propoxy)oxidophosphoryl)oxy)propoxy)oxidophospho
       ryl)oxy)propoxy)oxidophosphoryl)oxy)propyl phosphoryl linker

<220>
<221>  misc_feature
<222>  (26)..(26)
<223>  3' terminus modified by 3-hydroxypropyl 
       (3-((oxido(3-((oxido(3-((oxidophosphoryl)oxy)propoxy)phosphoryl)o
       xy)propoxy)phosphoryl)oxy)propyl) phosphate

<400>  1
tggggacttt ccatggaaag tcccca                                            26


<210>  2
<211>  26
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5' terminus modified by 
       3-(((3-(((3-(((3-(((3-hydroxypropoxy)oxidophosphoryl)oxy)propoxy)
       oxidophosphoryl)oxy)propoxy)oxidophosphoryl)oxy)propoxy)oxidophos
       phoryl)oxy)propyl

<220>
<221>  misc_feature
<222>  (13)..(14)
<223>  3-(((3-(((3-(((3-propoxy)oxidophosphoryl)oxy)propoxy)oxidophospho
       ryl)oxy)propoxy)oxidophosphoryl)oxy)propyl phosphoryl linker

<220>
<221>  misc_feature
<222>  (26)..(26)
<223>  3' terminus modified by 3-hydroxypropyl 
       (3-((oxido(3-((oxido(3-((oxidophosphoryl)oxy)propoxy)phosphoryl)o
       xy)propoxy)phosphoryl)oxy)propyl) phosphate

<400>  2
tggaaagtcc ccatggggac tttcca                                            26


<210>  3
<211>  44
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5' terminus modified by 
       3-(((3-(((3-(((3-(((3-hydroxypropoxy)oxidophosphoryl)oxy)propoxy)
       oxidophosphoryl)oxy)propoxy)oxidophosphoryl)oxy)propoxy)oxidophos
       phoryl)oxy)propyl

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  phosphorothioate linker

<220>
<221>  misc_feature
<222>  (2)..(3)
<223>  phosphorothioate linker

<220>
<221>  misc_feature
<222>  (3)..(4)
<223>  phosphorothioate linker

<220>
<221>  misc_feature
<222>  (22)..(23)
<223>  3-(((3-(((3-(((3-propoxy)oxidophosphoryl)oxy)propoxy)oxidophospho
       ryl)oxy)propoxy)oxidophosphoryl)oxy)propyl phosphoryl linker

<220>
<221>  misc_feature
<222>  (41)..(42)
<223>  phosphorothioate linker

<220>
<221>  misc_feature
<222>  (42)..(43)
<223>  phosphorothioate linker

<220>
<221>  misc_feature
<222>  (43)..(44)
<223>  phosphorothioate linker

<220>
<221>  misc_feature
<222>  (44)..(44)
<223>  3' terminus modified by 3-hydroxypropyl 
       (3-((oxido(3-((oxido(3-((oxidophosphoryl)oxy)propoxy)phosphoryl)o
       xy)propoxy)phosphoryl)oxy)propyl) phosphate

<400>  3
gatcgagggg actttcccta gcgctaggga aagtcccctc gatc                        44


<210>  4
<211>  40
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5' terminus modified by 
       3-(((3-(((3-(((3-(((3-hydroxypropoxy)oxidophosphoryl)oxy)propoxy)
       oxidophosphoryl)oxy)propoxy)oxidophosphoryl)oxy)propoxy)oxidophos
       phoryl)oxy)propyl

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  phosphorothioate linker

<220>
<221>  misc_feature
<222>  (2)..(3)
<223>  phosphorothioate linker

<220>
<221>  misc_feature
<222>  (3)..(4)
<223>  phosphorothioate linker

<220>
<221>  misc_feature
<222>  (20)..(21)
<223>  3-(((3-(((3-(((3-propoxy)oxidophosphoryl)oxy)propoxy)oxidophospho
       ryl)oxy)propoxy)oxidophosphoryl)oxy)propyl phosphoryl linker

<220>
<221>  misc_feature
<222>  (37)..(38)
<223>  phosphorothioate linker

<220>
<221>  misc_feature
<222>  (38)..(39)
<223>  phosphorothioate linker

<220>
<221>  misc_feature
<222>  (39)..(40)
<223>  phosphorothioate linker

<220>
<221>  misc_feature
<222>  (40)..(40)
<223>  3' terminus modified by 3-hydroxypropyl 
       (3-((oxido(3-((oxido(3-((oxidophosphoryl)oxy)propoxy)phosphoryl)o
       xy)propoxy)phosphoryl)oxy)propyl) phosphate

<400>  4
ccttgaaggg atttccctcc ggagggaaat cccttcaagg                             40


<210>  5
<211>  60
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  deoxythymidine

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  phosphorothioate linker

<220>
<221>  misc_feature
<222>  (2)..(3)
<223>  phosphorothioate linker

<220>
<221>  misc_feature
<222>  (3)..(4)
<223>  phosphorothioate linker

<220>
<221>  misc_feature
<222>  (4)..(5)
<223>  phosphorothioate linker

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  phosphorothioate linker

<220>
<221>  misc_feature
<222>  (6)..(7)
<223>  phosphorothioate linker

<220>
<221>  misc_feature
<222>  (7)..(8)
<223>  phosphorothioate linker

<220>
<221>  misc_feature
<222>  (8)..(9)
<223>  phosphorothioate linker

<220>
<221>  misc_feature
<222>  (9)..(10)
<223>  phosphorothioate linker

<220>
<221>  misc_feature
<222>  (10)..(11)
<223>  phosphorothioate linker

<220>
<221>  misc_feature
<222>  (11)..(12)
<223>  phosphorothioate linker

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  phosphorothioate linker

<220>
<221>  misc_feature
<222>  (13)..(14)
<223>  phosphorothioate linker

<220>
<221>  misc_feature
<222>  (14)..(15)
<223>  phosphorothioate linker

<220>
<221>  misc_feature
<222>  (15)..(16)
<223>  phosphorothioate linker

<220>
<221>  misc_feature
<222>  (16)..(17)
<223>  phosphorothioate linker

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  phosphorothioate linker

<220>
<221>  misc_feature
<222>  (18)..(19)
<223>  phosphorothioate linker

<220>
<221>  misc_feature
<222>  (19)..(20)
<223>  phosphorothioate linker

<220>
<221>  misc_feature
<222>  (20)..(21)
<223>  3-(((3-(((3-(((3-(((3-propoxy)oxidophosphoryl)oxy)propoxy)oxidoph
       osphoryl)oxy)propoxy)oxidophosphoryl)oxy)propoxy)oxidophosphoryl)
       oxy)propyl phosphoryl linker

<220>
<221>  misc_feature
<222>  (21)..(22)
<223>  phosphorothioate linker

<220>
<221>  misc_feature
<222>  (22)..(23)
<223>  phosphorothioate linker

<220>
<221>  misc_feature
<222>  (23)..(24)
<223>  phosphorothioate linker

<220>
<221>  misc_feature
<222>  (40)..(41)
<223>  3-(((3-(((3-(((3-propoxy)oxidophosphoryl)oxy)propoxy)oxidophospho
       ryl)oxy)propoxy)oxidophosphoryl)oxy)propyl phosphoryl linker

<220>
<221>  misc_feature
<222>  (57)..(58)
<223>  phosphorothioate linker

<220>
<221>  misc_feature
<222>  (58)..(59)
<223>  phosphorothioate linker

<220>
<221>  misc_feature
<222>  (59)..(60)
<223>  phosphorothioate linker

<220>
<221>  misc_feature
<222>  (60)..(60)
<223>  3' terminus modified by 3-hydroxypropyl 
       (3-((oxido(3-((oxido(3-((oxidophosphoryl)oxy)propoxy)phosphoryl)o
       xy)propoxy)phosphoryl)oxy)propyl) phosphate

<400>  5
tccatgacgt tcctgatgct ccttgaaggg atttccctcc ggagggaaat cccttcaagg       60


<210>  6
<211>  60
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  deoxythymidine

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  phosphorothioate linker

<220>
<221>  misc_feature
<222>  (2)..(3)
<223>  phosphorothioate linker

<220>
<221>  misc_feature
<222>  (3)..(4)
<223>  phosphorothioate linker

<220>
<221>  misc_feature
<222>  (4)..(5)
<223>  phosphorothioate linker

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  phosphorothioate linker

<220>
<221>  misc_feature
<222>  (6)..(7)
<223>  phosphorothioate linker

<220>
<221>  misc_feature
<222>  (7)..(8)
<223>  phosphorothioate linker

<220>
<221>  misc_feature
<222>  (8)..(9)
<223>  phosphorothioate linker

<220>
<221>  misc_feature
<222>  (9)..(10)
<223>  phosphorothioate linker

<220>
<221>  misc_feature
<222>  (10)..(11)
<223>  phosphorothioate linker

<220>
<221>  misc_feature
<222>  (11)..(12)
<223>  phosphorothioate linker

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  phosphorothioate linker

<220>
<221>  misc_feature
<222>  (13)..(14)
<223>  phosphorothioate linker

<220>
<221>  misc_feature
<222>  (14)..(15)
<223>  phosphorothioate linker

<220>
<221>  misc_feature
<222>  (15)..(16)
<223>  phosphorothioate linker

<220>
<221>  misc_feature
<222>  (16)..(17)
<223>  phosphorothioate linker

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  phosphorothioate linker

<220>
<221>  misc_feature
<222>  (18)..(19)
<223>  phosphorothioate linker

<220>
<221>  misc_feature
<222>  (19)..(20)
<223>  phosphorothioate linker

<220>
<221>  misc_feature
<222>  (20)..(21)
<223>  3-(((3-(((3-(((3-(((3-propoxy)oxidophosphoryl)oxy)propoxy)oxidoph
       osphoryl)oxy)propoxy)oxidophosphoryl)oxy)propoxy)oxidophosphoryl)
       oxy)propyl phosphoryl linker

<220>
<221>  misc_feature
<222>  (21)..(22)
<223>  phosphorothioate linker

<220>
<221>  misc_feature
<222>  (22)..(23)
<223>  phosphorothioate linker

<220>
<221>  misc_feature
<222>  (23)..(24)
<223>  phosphorothioate linker

<220>
<221>  misc_feature
<222>  (40)..(41)
<223>  3-(((3-(((3-(((3-propoxy)oxidophosphoryl)oxy)propoxy)oxidophospho
       ryl)oxy)propoxy)oxidophosphoryl)oxy)propyl phosphoryl linker

<220>
<221>  misc_feature
<222>  (57)..(58)
<223>  phosphorothioate linker

<220>
<221>  misc_feature
<222>  (58)..(59)
<223>  phosphorothioate linker

<220>
<221>  misc_feature
<222>  (59)..(60)
<223>  phosphorothioate linker

<220>
<221>  misc_feature
<222>  (60)..(60)
<223>  3' terminus modified by 3-hydroxypropyl 
       (3-((oxido(3-((oxido(3-((oxidophosphoryl)oxy)propoxy)phosphoryl)o
       xy)propoxy)phosphoryl)oxy)propyl) phosphate

<400>  6
tccatgagct tcctgatgct ccttgaaggg atttccctcc ggagggaaat cccttcaagg       60


<210>  7
<211>  60
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  deoxyguanosine

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  phosphorothioate linker

<220>
<221>  misc_feature
<222>  (2)..(3)
<223>  phosphorothioate linker

<220>
<221>  misc_feature
<222>  (16)..(17)
<223>  phosphorothioate linker

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  phosphorothioate linker

<220>
<221>  misc_feature
<222>  (18)..(19)
<223>  phosphorothioate linker

<220>
<221>  misc_feature
<222>  (19)..(20)
<223>  phosphorothioate linker

<220>
<221>  misc_feature
<222>  (20)..(21)
<223>  3-(((3-(((3-(((3-(((3-propoxy)oxidophosphoryl)oxy)propoxy)oxidoph
       osphoryl)oxy)propoxy)oxidophosphoryl)oxy)propoxy)oxidophosphoryl)
       oxy)propyl phosphoryl linker

<220>
<221>  misc_feature
<222>  (21)..(22)
<223>  phosphorothioate linker

<220>
<221>  misc_feature
<222>  (22)..(23)
<223>  phosphorothioate linker

<220>
<221>  misc_feature
<222>  (23)..(24)
<223>  phosphorothioate linker

<220>
<221>  misc_feature
<222>  (40)..(41)
<223>  3-(((3-(((3-(((3-propoxy)oxidophosphoryl)oxy)propoxy)oxidophospho
       ryl)oxy)propoxy)oxidophosphoryl)oxy)propyl phosphoryl linker

<220>
<221>  misc_feature
<222>  (57)..(58)
<223>  phosphorothioate linker

<220>
<221>  misc_feature
<222>  (58)..(59)
<223>  phosphorothioate linker

<220>
<221>  misc_feature
<222>  (59)..(60)
<223>  phosphorothioate linker

<220>
<221>  misc_feature
<222>  (60)..(60)
<223>  3' terminus modified by 3-hydroxypropyl 
       (3-((oxido(3-((oxido(3-((oxidophosphoryl)oxy)propoxy)phosphoryl)o
       xy)propoxy)phosphoryl)oxy)propyl) phosphate

<400>  7
ggtgcatcga tgcagggggg ccttgaaggg atttccctcc ggagggaaat cccttcaagg       60


<210>  8
<211>  60
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  deoxyguanosine

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  phosphorothioate linker

<220>
<221>  misc_feature
<222>  (2)..(3)
<223>  phosphorothioate linker

<220>
<221>  misc_feature
<222>  (16)..(17)
<223>  phosphorothioate linker

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  phosphorothioate linker

<220>
<221>  misc_feature
<222>  (18)..(19)
<223>  phosphorothioate linker

<220>
<221>  misc_feature
<222>  (19)..(20)
<223>  phosphorothioate linker

<220>
<221>  misc_feature
<222>  (20)..(21)
<223>  3-(((3-(((3-(((3-(((3-propoxy)oxidophosphoryl)oxy)propoxy)oxidoph
       osphoryl)oxy)propoxy)oxidophosphoryl)oxy)propoxy)oxidophosphoryl)
       oxy)propyl phosphoryl linker

<220>
<221>  misc_feature
<222>  (21)..(22)
<223>  phosphorothioate linker

<220>
<221>  misc_feature
<222>  (22)..(23)
<223>  phosphorothioate linker

<220>
<221>  misc_feature
<222>  (23)..(24)
<223>  phosphorothioate linker

<220>
<221>  misc_feature
<222>  (40)..(41)
<223>  3-(((3-(((3-(((3-propoxy)oxidophosphoryl)oxy)propoxy)oxidophospho
       ryl)oxy)propoxy)oxidophosphoryl)oxy)propyl phosphoryl linker

<220>
<221>  misc_feature
<222>  (57)..(58)
<223>  phosphorothioate linker

<220>
<221>  misc_feature
<222>  (58)..(59)
<223>  phosphorothioate linker

<220>
<221>  misc_feature
<222>  (59)..(60)
<223>  phosphorothioate linker

<220>
<221>  misc_feature
<222>  (60)..(60)
<223>  3' terminus modified by 3-hydroxypropyl 
       (3-((oxido(3-((oxido(3-((oxidophosphoryl)oxy)propoxy)phosphoryl)o
       xy)propoxy)phosphoryl)oxy)propyl) phosphate

<400>  8
ggtgcatgca tgcagggggg ccttgaaggg atttccctcc ggagggaaat cccttcaagg       60


<210>  9
<211>  26
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5' terminus modified by 
       3-(((3-(((3-(((3-(((3-hydroxypropoxy)oxidophosphoryl)oxy)propoxy)
       oxidophosphoryl)oxy)propoxy)oxidophosphoryl)oxy)propoxy)oxidophos
       phoryl)oxy)propyl

<220>
<221>  misc_feature
<222>  (13)..(14)
<223>  3-(((3-(((3-(((3-propoxy)oxidophosphoryl)oxy)propoxy)oxidophospho
       ryl)oxy)propoxy)oxidophosphoryl)oxy)propyl phosphoryl linker

<220>
<221>  misc_feature
<222>  (26)..(26)
<223>  3' terminus modified by 6-aminohexyl 
       (3-((oxido(3-((oxido(3-((oxidophosphoryl)oxy)propoxy)phosphoryl)o
       xy)propoxy)phosphoryl)oxy)propyl) phosphate

<400>  9
tggggacttt ccatggaaag tcccca                                            26


<210>  10
<211>  26
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5' terminus modified by 
       3-(((3-(((3-(((3-(((3-hydroxypropoxy)oxidophosphoryl)oxy)propoxy)
       oxidophosphoryl)oxy)propoxy)oxidophosphoryl)oxy)propoxy)oxidophos
       phoryl)oxy)propyl

<220>
<221>  misc_feature
<222>  (13)..(14)
<223>  3-(((3-(((3-(((3-propoxy)oxidophosphoryl)oxy)propoxy)oxidophospho
       ryl)oxy)propoxy)oxidophosphoryl)oxy)propyl phosphoryl linker

<220>
<221>  misc_feature
<222>  (26)..(26)
<223>  3' terminus modified by 6-aminohexyl 
       (3-((oxido(3-((oxido(3-((oxidophosphoryl)oxy)propoxy)phosphoryl)o
       xy)propoxy)phosphoryl)oxy)propyl) phosphate

<400>  10
tggaaagtcc ccatggggac tttcca                                            26


<210>  11
<211>  44
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5' terminus modified by 
       3-(((3-(((3-(((3-(((3-hydroxypropoxy)oxidophosphoryl)oxy)propoxy)
       oxidophosphoryl)oxy)propoxy)oxidophosphoryl)oxy)propoxy)oxidophos
       phoryl)oxy)propyl

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  phosphorothioate linker

<220>
<221>  misc_feature
<222>  (2)..(3)
<223>  phosphorothioate linker

<220>
<221>  misc_feature
<222>  (3)..(4)
<223>  phosphorothioate linker

<220>
<221>  misc_feature
<222>  (22)..(23)
<223>  3-(((3-(((3-(((3-propoxy)oxidophosphoryl)oxy)propoxy)oxidophospho
       ryl)oxy)propoxy)oxidophosphoryl)oxy)propyl phosphoryl linker

<220>
<221>  misc_feature
<222>  (41)..(42)
<223>  phosphorothioate linker

<220>
<221>  misc_feature
<222>  (42)..(43)
<223>  phosphorothioate linker

<220>
<221>  misc_feature
<222>  (43)..(44)
<223>  phosphorothioate linker

<220>
<221>  misc_feature
<222>  (44)..(44)
<223>  3' terminus modified by 6-aminohexyl 
       (3-((oxido(3-((oxido(3-((oxidophosphoryl)oxy)propoxy)phosphoryl)o
       xy)propoxy)phosphoryl)oxy)propyl) phosphate

<400>  11
gatcgagggg actttcccta gcgctaggga aagtcccctc gatc                        44


<210>  12
<211>  40
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5' terminus modified by 
       3-(((3-(((3-(((3-(((3-hydroxypropoxy)oxidophosphoryl)oxy)propoxy)
       oxidophosphoryl)oxy)propoxy)oxidophosphoryl)oxy)propoxy)oxidophos
       phoryl)oxy)propyl

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  phosphorothioate linker

<220>
<221>  misc_feature
<222>  (2)..(3)
<223>  phosphorothioate linker

<220>
<221>  misc_feature
<222>  (3)..(4)
<223>  phosphorothioate linker

<220>
<221>  misc_feature
<222>  (20)..(21)
<223>  3-(((3-(((3-(((3-propoxy)oxidophosphoryl)oxy)propoxy)oxidophospho
       ryl)oxy)propoxy)oxidophosphoryl)oxy)propyl phosphoryl linker

<220>
<221>  misc_feature
<222>  (37)..(38)
<223>  phosphorothioate linker

<220>
<221>  misc_feature
<222>  (38)..(39)
<223>  phosphorothioate linker

<220>
<221>  misc_feature
<222>  (39)..(40)
<223>  phosphorothioate linker

<220>
<221>  misc_feature
<222>  (40)..(40)
<223>  3' terminus modified by 6-aminohexyl 
       (3-((oxido(3-((oxido(3-((oxidophosphoryl)oxy)propoxy)phosphoryl)o
       xy)propoxy)phosphoryl)oxy)propyl) phosphate

<400>  12
ccttgaaggg atttccctcc ggagggaaat cccttcaagg                             40


<210>  13
<211>  60
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  deoxythymidine

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  phosphorothioate linker

<220>
<221>  misc_feature
<222>  (2)..(3)
<223>  phosphorothioate linker

<220>
<221>  misc_feature
<222>  (3)..(4)
<223>  phosphorothioate linker

<220>
<221>  misc_feature
<222>  (4)..(5)
<223>  phosphorothioate linker

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  phosphorothioate linker

<220>
<221>  misc_feature
<222>  (6)..(7)
<223>  phosphorothioate linker

<220>
<221>  misc_feature
<222>  (7)..(8)
<223>  phosphorothioate linker

<220>
<221>  misc_feature
<222>  (8)..(9)
<223>  phosphorothioate linker

<220>
<221>  misc_feature
<222>  (9)..(10)
<223>  phosphorothioate linker

<220>
<221>  misc_feature
<222>  (10)..(11)
<223>  phosphorothioate linker

<220>
<221>  misc_feature
<222>  (11)..(12)
<223>  phosphorothioate linker

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  phosphorothioate linker

<220>
<221>  misc_feature
<222>  (13)..(14)
<223>  phosphorothioate linker

<220>
<221>  misc_feature
<222>  (14)..(15)
<223>  phosphorothioate linker

<220>
<221>  misc_feature
<222>  (15)..(16)
<223>  phosphorothioate linker

<220>
<221>  misc_feature
<222>  (16)..(17)
<223>  phosphorothioate linker

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  phosphorothioate linker

<220>
<221>  misc_feature
<222>  (18)..(19)
<223>  phosphorothioate linker

<220>
<221>  misc_feature
<222>  (19)..(20)
<223>  phosphorothioate linker

<220>
<221>  misc_feature
<222>  (20)..(21)
<223>  3-(((3-(((3-(((3-(((3-propoxy)oxidophosphoryl)oxy)propoxy)oxidoph
       osphoryl)oxy)propoxy)oxidophosphoryl)oxy)propoxy)oxidophosphoryl)
       oxy)propyl phosphoryl linker

<220>
<221>  misc_feature
<222>  (21)..(22)
<223>  phosphorothioate linker

<220>
<221>  misc_feature
<222>  (22)..(23)
<223>  phosphorothioate linker

<220>
<221>  misc_feature
<222>  (23)..(24)
<223>  phosphorothioate linker

<220>
<221>  misc_feature
<222>  (40)..(41)
<223>  3-(((3-(((3-(((3-propoxy)oxidophosphoryl)oxy)propoxy)oxidophospho
       ryl)oxy)propoxy)oxidophosphoryl)oxy)propyl phosphoryl linker

<220>
<221>  misc_feature
<222>  (57)..(58)
<223>  phosphorothioate linker

<220>
<221>  misc_feature
<222>  (58)..(59)
<223>  phosphorothioate linker

<220>
<221>  misc_feature
<222>  (59)..(60)
<223>  phosphorothioate linker

<220>
<221>  misc_feature
<222>  (60)..(60)
<223>  3' terminus modified by 6-aminohexyl 
       (3-((oxido(3-((oxido(3-((oxidophosphoryl)oxy)propoxy)phosphoryl)o
       xy)propoxy)phosphoryl)oxy)propyl) phosphate

<400>  13
tccatgacgt tcctgatgct ccttgaaggg atttccctcc ggagggaaat cccttcaagg       60


<210>  14
<211>  60
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  deoxythymidine

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  phosphorothioate linker

<220>
<221>  misc_feature
<222>  (2)..(3)
<223>  phosphorothioate linker

<220>
<221>  misc_feature
<222>  (3)..(4)
<223>  phosphorothioate linker

<220>
<221>  misc_feature
<222>  (4)..(5)
<223>  phosphorothioate linker

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  phosphorothioate linker

<220>
<221>  misc_feature
<222>  (6)..(7)
<223>  phosphorothioate linker

<220>
<221>  misc_feature
<222>  (7)..(8)
<223>  phosphorothioate linker

<220>
<221>  misc_feature
<222>  (8)..(9)
<223>  phosphorothioate linker

<220>
<221>  misc_feature
<222>  (9)..(10)
<223>  phosphorothioate linker

<220>
<221>  misc_feature
<222>  (10)..(11)
<223>  phosphorothioate linker

<220>
<221>  misc_feature
<222>  (11)..(12)
<223>  phosphorothioate linker

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  phosphorothioate linker

<220>
<221>  misc_feature
<222>  (13)..(14)
<223>  phosphorothioate linker

<220>
<221>  misc_feature
<222>  (14)..(15)
<223>  phosphorothioate linker

<220>
<221>  misc_feature
<222>  (15)..(16)
<223>  phosphorothioate linker

<220>
<221>  misc_feature
<222>  (16)..(17)
<223>  phosphorothioate linker

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  phosphorothioate linker

<220>
<221>  misc_feature
<222>  (18)..(19)
<223>  phosphorothioate linker

<220>
<221>  misc_feature
<222>  (19)..(20)
<223>  phosphorothioate linker

<220>
<221>  misc_feature
<222>  (20)..(21)
<223>  3-(((3-(((3-(((3-(((3-propoxy)oxidophosphoryl)oxy)propoxy)oxidoph
       osphoryl)oxy)propoxy)oxidophosphoryl)oxy)propoxy)oxidophosphoryl)
       oxy)propyl phosphoryl linker

<220>
<221>  misc_feature
<222>  (21)..(22)
<223>  phosphorothioate linker

<220>
<221>  misc_feature
<222>  (22)..(23)
<223>  phosphorothioate linker

<220>
<221>  misc_feature
<222>  (23)..(24)
<223>  phosphorothioate linker

<220>
<221>  misc_feature
<222>  (40)..(41)
<223>  3-(((3-(((3-(((3-propoxy)oxidophosphoryl)oxy)propoxy)oxidophospho
       ryl)oxy)propoxy)oxidophosphoryl)oxy)propyl phosphoryl linker

<220>
<221>  misc_feature
<222>  (57)..(58)
<223>  phosphorothioate linker

<220>
<221>  misc_feature
<222>  (58)..(59)
<223>  phosphorothioate linker

<220>
<221>  misc_feature
<222>  (59)..(60)
<223>  phosphorothioate linker

<220>
<221>  misc_feature
<222>  (60)..(60)
<223>  3' terminus modified by 6-aminohexyl 
       (3-((oxido(3-((oxido(3-((oxidophosphoryl)oxy)propoxy)phosphoryl)o
       xy)propoxy)phosphoryl)oxy)propyl) phosphate

<400>  14
tccatgagct tcctgatgct ccttgaaggg atttccctcc ggagggaaat cccttcaagg       60


<210>  15
<211>  60
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  deoxyguanosine

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  phosphorothioate linker

<220>
<221>  misc_feature
<222>  (2)..(3)
<223>  phosphorothioate linker

<220>
<221>  misc_feature
<222>  (16)..(17)
<223>  phosphorothioate linker

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  phosphorothioate linker

<220>
<221>  misc_feature
<222>  (18)..(19)
<223>  phosphorothioate linker

<220>
<221>  misc_feature
<222>  (19)..(20)
<223>  phosphorothioate linker

<220>
<221>  misc_feature
<222>  (20)..(21)
<223>  3-(((3-(((3-(((3-(((3-propoxy)oxidophosphoryl)oxy)propoxy)oxidoph
       osphoryl)oxy)propoxy)oxidophosphoryl)oxy)propoxy)oxidophosphoryl)
       oxy)propyl phosphoryl linker

<220>
<221>  misc_feature
<222>  (21)..(22)
<223>  phosphorothioate linker

<220>
<221>  misc_feature
<222>  (22)..(23)
<223>  phosphorothioate linker

<220>
<221>  misc_feature
<222>  (23)..(24)
<223>  phosphorothioate linker

<220>
<221>  misc_feature
<222>  (40)..(41)
<223>  3-(((3-(((3-(((3-propoxy)oxidophosphoryl)oxy)propoxy)oxidophospho
       ryl)oxy)propoxy)oxidophosphoryl)oxy)propyl phosphoryl linker

<220>
<221>  misc_feature
<222>  (57)..(58)
<223>  phosphorothioate linker

<220>
<221>  misc_feature
<222>  (58)..(59)
<223>  phosphorothioate linker

<220>
<221>  misc_feature
<222>  (59)..(60)
<223>  phosphorothioate linker

<220>
<221>  misc_feature
<222>  (60)..(60)
<223>  3' terminus modified by 6-aminohexyl 
       (3-((oxido(3-((oxido(3-((oxidophosphoryl)oxy)propoxy)phosphoryl)o
       xy)propoxy)phosphoryl)oxy)propyl) phosphate

<400>  15
ggtgcatcga tgcagggggg ccttgaaggg atttccctcc ggagggaaat cccttcaagg       60


<210>  16
<211>  60
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  deoxyguanosine

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  phosphorothioate linker

<220>
<221>  misc_feature
<222>  (2)..(3)
<223>  phosphorothioate linker

<220>
<221>  misc_feature
<222>  (16)..(17)
<223>  phosphorothioate linker

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  phosphorothioate linker

<220>
<221>  misc_feature
<222>  (18)..(19)
<223>  phosphorothioate linker

<220>
<221>  misc_feature
<222>  (19)..(20)
<223>  phosphorothioate linker

<220>
<221>  misc_feature
<222>  (20)..(21)
<223>  3-(((3-(((3-(((3-(((3-propoxy)oxidophosphoryl)oxy)propoxy)oxidoph
       osphoryl)oxy)propoxy)oxidophosphoryl)oxy)propoxy)oxidophosphoryl)
       oxy)propyl phosphoryl linker

<220>
<221>  misc_feature
<222>  (21)..(22)
<223>  phosphorothioate linker

<220>
<221>  misc_feature
<222>  (22)..(23)
<223>  phosphorothioate linker

<220>
<221>  misc_feature
<222>  (23)..(24)
<223>  phosphorothioate linker

<220>
<221>  misc_feature
<222>  (40)..(41)
<223>  3-(((3-(((3-(((3-propoxy)oxidophosphoryl)oxy)propoxy)oxidophospho
       ryl)oxy)propoxy)oxidophosphoryl)oxy)propyl phosphoryl linker

<220>
<221>  misc_feature
<222>  (57)..(58)
<223>  phosphorothioate linker

<220>
<221>  misc_feature
<222>  (58)..(59)
<223>  phosphorothioate linker

<220>
<221>  misc_feature
<222>  (59)..(60)
<223>  phosphorothioate linker

<220>
<221>  misc_feature
<222>  (60)..(60)
<223>  3' terminus modified by 6-aminohexyl 
       (3-((oxido(3-((oxido(3-((oxidophosphoryl)oxy)propoxy)phosphoryl)o
       xy)propoxy)phosphoryl)oxy)propyl) phosphate

<400>  16
ggtgcatgca tgcagggggg ccttgaaggg atttccctcc ggagggaaat cccttcaagg       60


<210>  17
<211>  50
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  deoxythymidine

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  phosphorothioate linker

<220>
<221>  misc_feature
<222>  (2)..(3)
<223>  phosphorothioate linker

<220>
<221>  misc_feature
<222>  (3)..(4)
<223>  phosphorothioate linker

<220>
<221>  misc_feature
<222>  (4)..(5)
<223>  phosphorothioate linker

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  phosphorothioate linker

<220>
<221>  misc_feature
<222>  (6)..(7)
<223>  phosphorothioate linker

<220>
<221>  misc_feature
<222>  (7)..(8)
<223>  phosphorothioate linker

<220>
<221>  misc_feature
<222>  (8)..(9)
<223>  phosphorothioate linker

<220>
<221>  misc_feature
<222>  (9)..(10)
<223>  phosphorothioate linker

<220>
<221>  misc_feature
<222>  (10)..(11)
<223>  phosphorothioate linker

<220>
<221>  misc_feature
<222>  (11)..(12)
<223>  phosphorothioate linker

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  phosphorothioate linker

<220>
<221>  misc_feature
<222>  (13)..(14)
<223>  phosphorothioate linker

<220>
<221>  misc_feature
<222>  (14)..(15)
<223>  phosphorothioate linker

<220>
<221>  misc_feature
<222>  (15)..(16)
<223>  phosphorothioate linker

<220>
<221>  misc_feature
<222>  (16)..(17)
<223>  phosphorothioate linker

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  phosphorothioate linker

<220>
<221>  misc_feature
<222>  (18)..(19)
<223>  phosphorothioate linker

<220>
<221>  misc_feature
<222>  (19)..(20)
<223>  phosphorothioate linker

<220>
<221>  misc_feature
<222>  (20)..(21)
<223>  3-(((3-(((3-(((3-(((3-propoxy)oxidophosphoryl)oxy)propoxy)oxidoph
       osphoryl)oxy)propoxy)oxidophosphoryl)oxy)propoxy)oxidophosphoryl)
       oxy)propyl phosphoryl linker

<220>
<221>  misc_feature
<222>  (21)..(22)
<223>  phosphorothioate linker

<220>
<221>  misc_feature
<222>  (22)..(23)
<223>  phosphorothioate linker

<220>
<221>  misc_feature
<222>  (23)..(24)
<223>  phosphorothioate linker

<220>
<221>  misc_feature
<222>  (35)..(36)
<223>  3-(((3-(((3-(((3-propoxy)oxidophosphoryl)oxy)propoxy)oxidophospho
       ryl)oxy)propoxy)oxidophosphoryl)oxy)propyl phosphoryl linker

<220>
<221>  misc_feature
<222>  (48)..(49)
<223>  phosphorothioate linker

<220>
<221>  misc_feature
<222>  (49)..(50)
<223>  phosphorothioate linker

<220>
<221>  misc_feature
<222>  (50)..(50)
<223>  phosphorothioate linker

<220>
<221>  misc_feature
<222>  (50)..(50)
<223>  3' terminus modified by 3-hydroxypropyl 
       (3-((oxido(3-((oxido(3-((oxidophosphoryl)oxy)propoxy)phosphoryl)o
       xy)propoxy)phosphoryl)oxy)propyl) phosphate

<400>  17
tccatgacgt tcctgatgct actcttgcca attacgtaat tggcaagagt                  50


<210>  18
<211>  288
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  18

Met Gln Ile Pro Gln Ala Pro Trp Pro Val Val Trp Ala Val Leu Gln 
1               5                   10                  15      


Leu Gly Trp Arg Pro Gly Trp Phe Leu Asp Ser Pro Asp Arg Pro Trp 
            20                  25                  30          


Asn Pro Pro Thr Phe Ser Pro Ala Leu Leu Val Val Thr Glu Gly Asp 
        35                  40                  45              


Asn Ala Thr Phe Thr Cys Ser Phe Ser Asn Thr Ser Glu Ser Phe Val 
    50                  55                  60                  


Leu Asn Trp Tyr Arg Met Ser Pro Ser Asn Gln Thr Asp Lys Leu Ala 
65                  70                  75                  80  


Ala Phe Pro Glu Asp Arg Ser Gln Pro Gly Gln Asp Cys Arg Phe Arg 
                85                  90                  95      


Val Thr Gln Leu Pro Asn Gly Arg Asp Phe His Met Ser Val Val Arg 
            100                 105                 110         


Ala Arg Arg Asn Asp Ser Gly Thr Tyr Leu Cys Gly Ala Ile Ser Leu 
        115                 120                 125             


Ala Pro Lys Ala Gln Ile Lys Glu Ser Leu Arg Ala Glu Leu Arg Val 
    130                 135                 140                 


Thr Glu Arg Arg Ala Glu Val Pro Thr Ala His Pro Ser Pro Ser Pro 
145                 150                 155                 160 


Arg Pro Ala Gly Gln Phe Gln Thr Leu Val Val Gly Val Val Gly Gly 
                165                 170                 175     


Leu Leu Gly Ser Leu Val Leu Leu Val Trp Val Leu Ala Val Ile Cys 
            180                 185                 190         


Ser Arg Ala Ala Arg Gly Thr Ile Gly Ala Arg Arg Thr Gly Gln Pro 
        195                 200                 205             


Leu Lys Glu Asp Pro Ser Ala Val Pro Val Phe Ser Val Asp Tyr Gly 
    210                 215                 220                 


Glu Leu Asp Phe Gln Trp Arg Glu Lys Thr Pro Glu Pro Pro Val Pro 
225                 230                 235                 240 


Cys Val Pro Glu Gln Thr Glu Tyr Ala Thr Ile Val Phe Pro Ser Gly 
                245                 250                 255     


Met Gly Thr Ser Ser Pro Ala Arg Arg Gly Ser Ala Asp Gly Pro Arg 
            260                 265                 270         


Ser Ala Gln Pro Leu Arg Pro Glu Asp Gly His Cys Ser Trp Pro Leu 
        275                 280                 285             


<210>  19
<211>  290
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  19

Met Arg Ile Phe Ala Val Phe Ile Phe Met Thr Tyr Trp His Leu Leu 
1               5                   10                  15      


Asn Ala Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Val Val Glu Tyr 
            20                  25                  30          


Gly Ser Asn Met Thr Ile Glu Cys Lys Phe Pro Val Glu Lys Gln Leu 
        35                  40                  45              


Asp Leu Ala Ala Leu Ile Val Tyr Trp Glu Met Glu Asp Lys Asn Ile 
    50                  55                  60                  


Ile Gln Phe Val His Gly Glu Glu Asp Leu Lys Val Gln His Ser Ser 
65                  70                  75                  80  


Tyr Arg Gln Arg Ala Arg Leu Leu Lys Asp Gln Leu Ser Leu Gly Asn 
                85                  90                  95      


Ala Ala Leu Gln Ile Thr Asp Val Lys Leu Gln Asp Ala Gly Val Tyr 
            100                 105                 110         


Arg Cys Met Ile Ser Tyr Gly Gly Ala Asp Tyr Lys Arg Ile Thr Val 
        115                 120                 125             


Lys Val Asn Ala Pro Tyr Asn Lys Ile Asn Gln Arg Ile Leu Val Val 
    130                 135                 140                 


Asp Pro Val Thr Ser Glu His Glu Leu Thr Cys Gln Ala Glu Gly Tyr 
145                 150                 155                 160 


Pro Lys Ala Glu Val Ile Trp Thr Ser Ser Asp His Gln Val Leu Ser 
                165                 170                 175     


Gly Lys Thr Thr Thr Thr Asn Ser Lys Arg Glu Glu Lys Leu Phe Asn 
            180                 185                 190         


Val Thr Ser Thr Leu Arg Ile Asn Thr Thr Thr Asn Glu Ile Phe Tyr 
        195                 200                 205             


Cys Thr Phe Arg Arg Leu Asp Pro Glu Glu Asn His Thr Ala Glu Leu 
    210                 215                 220                 


Val Ile Pro Glu Leu Pro Leu Ala His Pro Pro Asn Glu Arg Thr His 
225                 230                 235                 240 


Leu Val Ile Leu Gly Ala Ile Leu Leu Cys Leu Gly Val Ala Leu Thr 
                245                 250                 255     


Phe Ile Phe Arg Leu Arg Lys Gly Arg Met Met Asp Val Lys Lys Cys 
            260                 265                 270         


Gly Ile Gln Asp Thr Asn Ser Lys Lys Gln Ser Asp Thr His Leu Glu 
        275                 280                 285             


Glu Thr 
    290 


<210>  20
<211>  223
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  20

Met Ala Cys Leu Gly Phe Gln Arg His Lys Ala Gln Leu Asn Leu Ala 
1               5                   10                  15      


Thr Arg Thr Trp Pro Cys Thr Leu Leu Phe Phe Leu Leu Phe Ile Pro 
            20                  25                  30          


Val Phe Cys Lys Ala Met His Val Ala Gln Pro Ala Val Val Leu Ala 
        35                  40                  45              


Ser Ser Arg Gly Ile Ala Ser Phe Val Cys Glu Tyr Ala Ser Pro Gly 
    50                  55                  60                  


Lys Ala Thr Glu Val Arg Val Thr Val Leu Arg Gln Ala Asp Ser Gln 
65                  70                  75                  80  


Val Thr Glu Val Cys Ala Ala Thr Tyr Met Met Gly Asn Glu Leu Thr 
                85                  90                  95      


Phe Leu Asp Asp Ser Ile Cys Thr Gly Thr Ser Ser Gly Asn Gln Val 
            100                 105                 110         


Asn Leu Thr Ile Gln Gly Leu Arg Ala Met Asp Thr Gly Leu Tyr Ile 
        115                 120                 125             


Cys Lys Val Glu Leu Met Tyr Pro Pro Pro Tyr Tyr Leu Gly Ile Gly 
    130                 135                 140                 


Asn Gly Thr Gln Ile Tyr Val Ile Asp Pro Glu Pro Cys Pro Asp Ser 
145                 150                 155                 160 


Asp Phe Leu Leu Trp Ile Leu Ala Ala Val Ser Ser Gly Leu Phe Phe 
                165                 170                 175     


Tyr Ser Phe Leu Leu Thr Ala Val Ser Leu Ser Lys Met Leu Lys Lys 
            180                 185                 190         


Arg Ser Pro Leu Thr Thr Gly Val Tyr Val Lys Met Pro Pro Thr Glu 
        195                 200                 205             


Pro Glu Cys Glu Lys Gln Phe Gln Pro Tyr Phe Ile Pro Ile Asn 
    210                 215                 220             


<210>  21
<211>  50
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  deoxythymidine

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  phosphorothioate linker

<220>
<221>  misc_feature
<222>  (2)..(3)
<223>  phosphorothioate linker

<220>
<221>  misc_feature
<222>  (3)..(4)
<223>  phosphorothioate linker

<220>
<221>  misc_feature
<222>  (4)..(5)
<223>  phosphorothioate linker

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  phosphorothioate linker

<220>
<221>  misc_feature
<222>  (6)..(7)
<223>  phosphorothioate linker

<220>
<221>  misc_feature
<222>  (7)..(8)
<223>  phosphorothioate linker

<220>
<221>  misc_feature
<222>  (8)..(9)
<223>  phosphorothioate linker

<220>
<221>  misc_feature
<222>  (9)..(10)
<223>  phosphorothioate linker

<220>
<221>  misc_feature
<222>  (10)..(11)
<223>  phosphorothioate linker

<220>
<221>  misc_feature
<222>  (11)..(12)
<223>  phosphorothioate linker

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  phosphorothioate linker

<220>
<221>  misc_feature
<222>  (13)..(14)
<223>  phosphorothioate linker

<220>
<221>  misc_feature
<222>  (14)..(15)
<223>  phosphorothioate linker

<220>
<221>  misc_feature
<222>  (15)..(16)
<223>  phosphorothioate linker

<220>
<221>  misc_feature
<222>  (16)..(17)
<223>  phosphorothioate linker

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  phosphorothioate linker

<220>
<221>  misc_feature
<222>  (18)..(19)
<223>  phosphorothioate linker

<220>
<221>  misc_feature
<222>  (19)..(20)
<223>  phosphorothioate linker

<220>
<221>  misc_feature
<222>  (20)..(21)
<223>  3-(((3-(((3-(((3-(((3-propoxy)oxidophosphoryl)oxy)propoxy)oxidoph
       osphoryl)oxy)propoxy)oxidophosphoryl)oxy)propoxy)oxidophosphoryl)
       oxy)propyl phosphoryl linker

<220>
<221>  misc_feature
<222>  (21)..(22)
<223>  phosphorothioate linker

<220>
<221>  misc_feature
<222>  (22)..(23)
<223>  phosphorothioate linker

<220>
<221>  misc_feature
<222>  (23)..(24)
<223>  phosphorothioate linker

<220>
<221>  misc_feature
<222>  (35)..(36)
<223>  3-(((3-(((3-(((3-propoxy)oxidophosphoryl)oxy)propoxy)oxidophospho
       ryl)oxy)propoxy)oxidophosphoryl)oxy)propyl phosphoryl linker

<220>
<221>  misc_feature
<222>  (48)..(49)
<223>  phosphorothioate linker

<220>
<221>  misc_feature
<222>  (49)..(50)
<223>  phosphorothioate linker

<220>
<221>  misc_feature
<222>  (50)..(50)
<223>  phosphorothioate linker

<220>
<221>  misc_feature
<222>  (50)..(50)
<223>  3' terminus modified by 6-aminohexyl 
       (3-((oxido(3-((oxido(3-((oxidophosphoryl)oxy)propoxy)phosphoryl)o
       xy)propoxy)phosphoryl)oxy)propyl) phosphate

<400>  21
tccatgacgt tcctgatgct actcttgcca attacgtaat tggcaagagt                  50


