                         SEQUENCE LISTING

<110>  Fraunhofer-Gesellschaft zur Foerderung der angewandten 
       Forschung e.V.
 
<120>  method for detecting a modulator compound for chemical targeting 
       of protein-protein interactions

<130>  FHG16463PCT

<150>  EP 18 191 813.7
<151>  2018-08-30

<160>  34    

<170>  PatentIn version 3.5

<210>  1
<211>  419
<212>  PRT
<213>  Homo sapiens

<400>  1

Met Asn Arg His Leu Trp Lys Ser Gln Leu Cys Glu Met Val Gln Pro 
1               5                   10                  15      


Ser Gly Gly Pro Ala Ala Asp Gln Asp Val Leu Gly Glu Glu Ser Pro 
            20                  25                  30          


Leu Gly Lys Pro Ala Met Leu His Leu Pro Ser Glu Gln Gly Ala Pro 
        35                  40                  45              


Glu Thr Leu Gln Arg Cys Leu Glu Glu Asn Gln Glu Leu Arg Asp Ala 
    50                  55                  60                  


Ile Arg Gln Ser Asn Gln Ile Leu Arg Glu Arg Cys Glu Glu Leu Leu 
65                  70                  75                  80  


His Phe Gln Ala Ser Gln Arg Glu Glu Lys Glu Phe Leu Met Cys Lys 
                85                  90                  95      


Phe Gln Glu Ala Arg Lys Leu Val Glu Arg Leu Gly Leu Glu Lys Leu 
            100                 105                 110         


Asp Leu Lys Arg Gln Lys Glu Gln Ala Leu Arg Glu Val Glu His Leu 
        115                 120                 125             


Lys Arg Cys Gln Gln Gln Met Ala Glu Asp Lys Ala Ser Val Lys Ala 
    130                 135                 140                 


Gln Val Thr Ser Leu Leu Gly Glu Leu Gln Glu Ser Gln Ser Arg Leu 
145                 150                 155                 160 


Glu Ala Ala Thr Lys Glu Cys Gln Ala Leu Glu Gly Arg Ala Arg Ala 
                165                 170                 175     


Ala Ser Glu Gln Ala Arg Gln Leu Glu Ser Glu Arg Glu Ala Leu Gln 
            180                 185                 190         


Gln Gln His Ser Val Gln Val Asp Gln Leu Arg Met Gln Gly Gln Ser 
        195                 200                 205             


Val Glu Ala Ala Leu Arg Met Glu Arg Gln Ala Ala Ser Glu Glu Lys 
    210                 215                 220                 


Arg Lys Leu Ala Gln Leu Gln Val Ala Tyr His Gln Leu Phe Gln Glu 
225                 230                 235                 240 


Tyr Asp Asn His Ile Lys Ser Ser Val Val Gly Ser Glu Arg Lys Arg 
                245                 250                 255     


Gly Met Gln Leu Glu Asp Leu Lys Gln Gln Leu Gln Gln Ala Glu Glu 
            260                 265                 270         


Ala Leu Val Ala Lys Gln Glu Val Ile Asp Lys Leu Lys Glu Glu Ala 
        275                 280                 285             


Glu Gln His Lys Ile Val Met Glu Thr Val Pro Val Leu Lys Ala Gln 
    290                 295                 300                 


Ala Asp Ile Tyr Lys Ala Asp Phe Gln Ala Glu Arg Gln Ala Arg Glu 
305                 310                 315                 320 


Lys Leu Ala Glu Lys Lys Glu Leu Leu Gln Glu Gln Leu Glu Gln Leu 
                325                 330                 335     


Gln Arg Glu Tyr Ser Lys Leu Lys Ala Ser Cys Gln Glu Ser Ala Arg 
            340                 345                 350         


Ile Glu Asp Met Arg Lys Arg His Val Glu Val Ser Gln Ala Pro Leu 
        355                 360                 365             


Pro Pro Ala Pro Ala Tyr Leu Ser Ser Pro Leu Ala Leu Pro Ser Gln 
    370                 375                 380                 


Arg Arg Ser Pro Pro Glu Glu Pro Pro Asp Phe Cys Cys Pro Lys Cys 
385                 390                 395                 400 


Gln Tyr Gln Ala Pro Asp Met Asp Thr Leu Gln Ile His Val Met Glu 
                405                 410                 415     


Cys Ile Glu 
            


<210>  2
<211>  92
<212>  PRT
<213>  Homo sapiens

<400>  2

Lys Ser Ser Val Val Gly Ser Glu Arg Lys Arg Gly Met Gln Leu Glu 
1               5                   10                  15      


Asp Leu Lys Gln Gln Leu Gln Gln Ala Glu Glu Ala Leu Val Ala Lys 
            20                  25                  30          


Gln Glu Val Ile Asp Lys Leu Lys Glu Glu Ala Glu Gln His Lys Ile 
        35                  40                  45              


Val Met Glu Thr Val Pro Val Leu Lys Ala Gln Ala Asp Ile Tyr Lys 
    50                  55                  60                  


Ala Asp Phe Gln Ala Glu Arg Gln Ala Arg Glu Lys Leu Ala Glu Lys 
65                  70                  75                  80  


Lys Glu Leu Leu Gln Glu Gln Leu Glu Gln Leu Gln 
                85                  90          


<210>  3
<211>  158
<212>  PRT
<213>  Homo sapiens

<400>  3

Met Ser Gly Ile Ala Leu Ser Arg Leu Ala Gln Glu Arg Lys Ala Trp 
1               5                   10                  15      


Arg Lys Asp His Pro Phe Gly Phe Val Ala Val Pro Thr Lys Asn Pro 
            20                  25                  30          


Asp Gly Thr Met Asn Leu Met Asn Trp Glu Cys Ala Ile Pro Gly Lys 
        35                  40                  45              


Lys Gly Thr Pro Trp Glu Gly Gly Leu Phe Lys Leu Arg Met Leu Phe 
    50                  55                  60                  


Lys Asp Asp Tyr Pro Ser Ser Pro Pro Lys Cys Lys Phe Glu Pro Pro 
65                  70                  75                  80  


Leu Phe His Pro Asn Val Tyr Pro Ser Gly Thr Val Cys Leu Ser Ile 
                85                  90                  95      


Leu Glu Glu Asp Lys Asp Trp Arg Pro Ala Ile Thr Ile Lys Gln Ile 
            100                 105                 110         


Leu Leu Gly Ile Gln Glu Leu Leu Asn Glu Pro Asn Ile Gln Asp Pro 
        115                 120                 125             


Ala Gln Ala Glu Ala Tyr Thr Ile Tyr Cys Gln Asn Arg Val Glu Tyr 
    130                 135                 140                 


Glu Lys Arg Val Arg Ala Gln Ala Lys Lys Phe Ala Pro Ser 
145                 150                 155             


<210>  4
<211>  314
<212>  PRT
<213>  Homo sapiens

<400>  4

Met Gln Asn Val Ile Asn Thr Val Lys Gly Lys Ala Leu Glu Val Ala 
1               5                   10                  15      


Glu Tyr Leu Thr Pro Val Leu Lys Glu Ser Lys Phe Lys Glu Thr Gly 
            20                  25                  30          


Val Ile Thr Pro Glu Glu Phe Val Ala Ala Gly Asp His Leu Val His 
        35                  40                  45              


His Cys Pro Thr Trp Gln Trp Ala Thr Gly Glu Glu Leu Lys Val Lys 
    50                  55                  60                  


Ala Tyr Leu Pro Thr Gly Lys Gln Phe Leu Val Thr Lys Asn Val Pro 
65                  70                  75                  80  


Cys Tyr Lys Arg Cys Lys Gln Met Glu Tyr Ser Asp Glu Leu Glu Ala 
                85                  90                  95      


Ile Ile Glu Glu Asp Asp Gly Asp Gly Gly Trp Val Asp Thr Tyr His 
            100                 105                 110         


Asn Thr Gly Ile Thr Gly Ile Thr Glu Ala Val Lys Glu Ile Thr Leu 
        115                 120                 125             


Glu Asn Lys Asp Asn Ile Arg Leu Gln Asp Cys Ser Ala Leu Cys Glu 
    130                 135                 140                 


Glu Glu Glu Asp Glu Asp Glu Gly Glu Ala Ala Asp Met Glu Glu Tyr 
145                 150                 155                 160 


Glu Glu Ser Gly Leu Leu Glu Thr Asp Glu Ala Thr Leu Asp Thr Arg 
                165                 170                 175     


Lys Ile Val Glu Ala Cys Lys Ala Lys Thr Asp Ala Gly Gly Glu Asp 
            180                 185                 190         


Ala Ile Leu Gln Thr Arg Thr Tyr Asp Leu Tyr Ile Thr Tyr Asp Lys 
        195                 200                 205             


Tyr Tyr Gln Thr Pro Arg Leu Trp Leu Phe Gly Tyr Asp Glu Gln Arg 
    210                 215                 220                 


Gln Pro Leu Thr Val Glu His Met Tyr Glu Asp Ile Ser Gln Asp His 
225                 230                 235                 240 


Val Lys Lys Thr Val Thr Ile Glu Asn His Pro His Leu Pro Pro Pro 
                245                 250                 255     


Pro Met Cys Ser Val His Pro Cys Arg His Ala Glu Val Met Lys Lys 
            260                 265                 270         


Ile Ile Glu Thr Val Ala Glu Gly Gly Gly Glu Leu Gly Val His Met 
        275                 280                 285             


Tyr Leu Leu Ile Phe Leu Lys Phe Val Gln Ala Val Ile Pro Thr Ile 
    290                 295                 300                 


Glu Tyr Asp Tyr Thr Arg His Phe Thr Met 
305                 310                 


<210>  5
<211>  577
<212>  PRT
<213>  Homo sapiens

<400>  5

Met Ser His Gln Pro Leu Ser Cys Leu Thr Glu Lys Glu Asp Ser Pro 
1               5                   10                  15      


Ser Glu Ser Thr Gly Asn Gly Pro Pro His Leu Ala His Pro Asn Leu 
            20                  25                  30          


Asp Thr Phe Thr Pro Glu Glu Leu Leu Gln Gln Met Lys Glu Leu Leu 
        35                  40                  45              


Thr Glu Asn His Gln Leu Lys Glu Ala Met Lys Leu Asn Asn Gln Ala 
    50                  55                  60                  


Met Lys Gly Arg Phe Glu Glu Leu Ser Ala Trp Thr Glu Lys Gln Lys 
65                  70                  75                  80  


Glu Glu Arg Gln Phe Phe Glu Ile Gln Ser Lys Glu Ala Lys Glu Arg 
                85                  90                  95      


Leu Met Ala Leu Ser His Glu Asn Glu Lys Leu Lys Glu Glu Leu Gly 
            100                 105                 110         


Lys Leu Lys Gly Lys Ser Glu Arg Ser Ser Glu Asp Pro Thr Asp Asp 
        115                 120                 125             


Ser Arg Leu Pro Arg Ala Glu Ala Glu Gln Glu Lys Asp Gln Leu Arg 
    130                 135                 140                 


Thr Gln Val Val Arg Leu Gln Ala Glu Lys Ala Asp Leu Leu Gly Ile 
145                 150                 155                 160 


Val Ser Glu Leu Gln Leu Lys Leu Asn Ser Ser Gly Ser Ser Glu Asp 
                165                 170                 175     


Ser Phe Val Glu Ile Arg Met Ala Glu Gly Glu Ala Glu Gly Ser Val 
            180                 185                 190         


Lys Glu Ile Lys His Ser Pro Gly Pro Thr Arg Thr Val Ser Thr Gly 
        195                 200                 205             


Thr Ala Leu Ser Lys Tyr Arg Ser Arg Ser Ala Asp Gly Ala Lys Asn 
    210                 215                 220                 


Tyr Phe Glu His Glu Glu Leu Thr Val Ser Gln Leu Leu Leu Cys Leu 
225                 230                 235                 240 


Arg Glu Gly Asn Gln Lys Val Glu Arg Leu Glu Val Ala Leu Lys Glu 
                245                 250                 255     


Ala Lys Glu Arg Val Ser Asp Phe Glu Lys Lys Thr Ser Asn Arg Ser 
            260                 265                 270         


Glu Ile Glu Thr Gln Thr Glu Gly Ser Thr Glu Lys Glu Asn Asp Glu 
        275                 280                 285             


Glu Lys Gly Pro Glu Thr Val Gly Ser Glu Val Glu Ala Leu Asn Leu 
    290                 295                 300                 


Gln Val Thr Ser Leu Phe Lys Glu Leu Gln Glu Ala His Thr Lys Leu 
305                 310                 315                 320 


Ser Glu Ala Glu Leu Met Lys Lys Arg Leu Gln Glu Lys Cys Gln Ala 
                325                 330                 335     


Leu Glu Arg Lys Asn Ser Ala Ile Pro Ser Glu Leu Asn Glu Lys Gln 
            340                 345                 350         


Glu Leu Val Tyr Thr Asn Lys Lys Leu Glu Leu Gln Val Glu Ser Met 
        355                 360                 365             


Leu Ser Glu Ile Lys Met Glu Gln Ala Lys Thr Glu Asp Glu Lys Ser 
    370                 375                 380                 


Lys Leu Thr Val Leu Gln Met Thr His Asn Lys Leu Leu Gln Glu His 
385                 390                 395                 400 


Asn Asn Ala Leu Lys Thr Ile Glu Glu Leu Thr Arg Lys Glu Ser Glu 
                405                 410                 415     


Lys Val Asp Arg Ala Val Leu Lys Glu Leu Ser Glu Lys Leu Glu Leu 
            420                 425                 430         


Ala Glu Lys Ala Leu Ala Ser Lys Gln Leu Gln Met Asp Glu Met Lys 
        435                 440                 445             


Gln Thr Ile Ala Lys Gln Glu Glu Asp Leu Glu Thr Met Thr Ile Leu 
    450                 455                 460                 


Arg Ala Gln Met Glu Val Tyr Cys Ser Asp Phe His Ala Glu Arg Ala 
465                 470                 475                 480 


Ala Arg Glu Lys Ile His Glu Glu Lys Glu Gln Leu Ala Leu Gln Leu 
                485                 490                 495     


Ala Val Leu Leu Lys Glu Asn Asp Ala Phe Glu Asp Gly Gly Arg Gln 
            500                 505                 510         


Ser Leu Met Glu Met Gln Ser Arg His Gly Ala Arg Thr Ser Asp Ser 
        515                 520                 525             


Asp Gln Gln Ala Tyr Leu Val Gln Arg Gly Ala Glu Asp Arg Asp Trp 
    530                 535                 540                 


Arg Gln Gln Arg Asn Ile Pro Ile His Ser Cys Pro Lys Cys Gly Glu 
545                 550                 555                 560 


Val Leu Pro Asp Ile Asp Thr Leu Gln Ile His Val Met Asp Cys Ile 
                565                 570                 575     


Ile 
    


<210>  6
<211>  78
<212>  PRT
<213>  artificial sequence

<220>
<223>  Ubiquitin variant (Ubv-A)

<400>  6

Met Gln Ile Asn Val Lys Thr Leu Thr Gly Thr Thr Ile Gly Leu Glu 
1               5                   10                  15      


Val Glu Pro Ser Asp Thr Ile Glu Asn Val Lys Ala Lys Ile Gln Asp 
            20                  25                  30          


Lys Glu Gly Ile Pro Pro Asp Gln Gln Ile Leu Phe Phe Ser Gly Met 
        35                  40                  45              


Gln Leu Glu Asp Gly Arg Thr Leu Ser Asp Tyr Asn Ile Gln Lys Glu 
    50                  55                  60                  


Ser Arg Leu Tyr Leu Val Phe Ser Leu Arg Gly Arg Leu Gly 
65                  70                  75              


<210>  7
<211>  79
<212>  PRT
<213>  artificial sequence

<220>
<223>  small ubiquitin-like modifier 2 (SUMO2) variant

<400>  7

Asn Asp His Ile Asn Leu Thr Val Ala Gly Glu Asp Gly Ser Ala Val 
1               5                   10                  15      


Gln Phe Lys Ile Lys Arg His Thr Pro Leu Ser Lys Leu Met Lys Ala 
            20                  25                  30          


Tyr Cys Glu Arg Gln Gly Leu Ser Met Trp Gln Ile Arg Phe Arg Phe 
        35                  40                  45              


Asp Gly Gln Pro Ile Asn Glu Thr Asp Thr Pro Ala Gln Leu Glu Met 
    50                  55                  60                  


Glu Asp Glu Asp Gln Ile Asp Val Phe Gln Lys Tyr Thr Gly Thr 
65                  70                  75                  


<210>  8
<211>  120
<212>  PRT
<213>  artificial sequence

<220>
<223>  GATE16 variant

<400>  8

Met Lys Trp Met Phe Lys Glu Asp His Ser Leu Glu His Arg Cys Val 
1               5                   10                  15      


Glu Ser Ala Lys Ile Arg Ala Lys Tyr Pro Asp Arg Val Pro Val Ile 
            20                  25                  30          


Val Glu Lys Val Ser Gly Ser Gln Ile Val Asp Ile Asp Lys Arg Lys 
        35                  40                  45              


Tyr Leu Val Pro Ser Asp Ile Thr Val Ala Gln Phe Ile Trp Tyr Ile 
    50                  55                  60                  


Arg Lys Arg Ile Gln Leu Pro Ser Lys Lys Pro Ile Phe Leu Phe Val 
65                  70                  75                  80  


Asp Lys Ala Ile Pro Leu Ser Tyr Ser Ser Leu Thr Met Gly Gln Leu 
                85                  90                  95      


Tyr Glu Lys Glu Lys Asp Glu Asp Gly Phe Leu Tyr Val Ala Tyr Ser 
            100                 105                 110         


Gly Glu Asn Thr Phe Gly Thr Arg 
        115                 120 


<210>  9
<211>  119
<212>  PRT
<213>  artificial sequence

<220>
<223>  LC3B variant

<400>  9

Met Pro Ser Glu Lys Thr Leu Lys Gln Arg Leu Asn Phe Glu Leu Arg 
1               5                   10                  15      


Val Asp Asn Val Arg Leu Phe Arg Glu Gln His Pro Thr Lys Ile Pro 
            20                  25                  30          


Val Ile Ile Glu Arg Tyr Lys Gly Glu Lys Gln Leu Pro Val Leu Asp 
        35                  40                  45              


Ile Thr Gly Phe Leu Val Pro Asp His Val Asn Met Ser Glu Leu Ile 
    50                  55                  60                  


Lys Ile Ile Arg Arg Arg Leu Gln Leu Asn Ala Asn Gln Ala Phe Phe 
65                  70                  75                  80  


Leu Leu Val Asn Gly His Ser Met Val Ser Val Ser Thr Pro Ile Ser 
                85                  90                  95      


Glu Val Tyr Glu Ser Glu Lys Asp Glu Asp Gly Phe Leu Tyr Met Val 
            100                 105                 110         


Tyr Ala Ser Gln Glu Thr Phe 
        115                 


<210>  10
<211>  146
<212>  PRT
<213>  artificial sequence

<220>
<223>  Gal4 DNA binding domain (DBD)

<400>  10

Met Lys Leu Leu Ser Ser Ile Glu Gln Ala Cys Asp Ile Cys Arg Leu 
1               5                   10                  15      


Lys Lys Leu Lys Cys Ser Lys Glu Lys Pro Lys Cys Ala Lys Cys Leu 
            20                  25                  30          


Lys Asn Asn Trp Glu Cys Arg Tyr Ser Pro Lys Thr Lys Arg Ser Pro 
        35                  40                  45              


Leu Thr Arg Ala His Leu Thr Glu Val Glu Ser Arg Leu Glu Arg Leu 
    50                  55                  60                  


Glu Gln Leu Phe Leu Leu Ile Phe Pro Arg Glu Asp Leu Asp Met Ile 
65                  70                  75                  80  


Leu Lys Met Asp Ser Leu Gln Asp Ile Lys Ala Leu Leu Thr Gly Leu 
                85                  90                  95      


Phe Val Gln Asp Asn Val Asn Lys Asp Ala Val Thr Asp Arg Leu Ala 
            100                 105                 110         


Ser Val Glu Thr Asp Met Pro Leu Thr Leu Arg Gln His Arg Ile Ser 
        115                 120                 125             


Ala Thr Ser Ser Ser Glu Glu Ser Ser Asn Lys Gly Gln Arg Gln Leu 
    130                 135                 140                 


Thr Val 
145     


<210>  11
<211>  103
<212>  DNA
<213>  artificial sequence

<220>
<223>  Gal4 DBD binding site repeats

<400>  11
cggagtactg tcctccgagc ggagtactgt cctccgactc gagcggagta ctgtcctccg       60

atcggagtac tgtcctccgc gaattccgga gtactgtcct ccg                        103


<210>  12
<211>  591
<212>  PRT
<213>  Photinus pyralis

<400>  12

Met Glu Asp Ala Lys Asn Ile Lys Lys Gly Pro Ala Pro Phe Tyr Pro 
1               5                   10                  15      


Leu Glu Asp Gly Thr Ala Gly Glu Gln Leu His Lys Ala Met Lys Arg 
            20                  25                  30          


Tyr Ala Leu Val Pro Gly Thr Ile Ala Phe Thr Asp Ala His Ile Glu 
        35                  40                  45              


Val Asp Ile Thr Tyr Ala Glu Tyr Phe Glu Met Ser Val Arg Leu Ala 
    50                  55                  60                  


Glu Ala Met Lys Arg Tyr Gly Leu Asn Thr Asn His Arg Ile Val Val 
65                  70                  75                  80  


Cys Ser Glu Asn Ser Leu Gln Phe Phe Met Pro Val Leu Gly Ala Leu 
                85                  90                  95      


Phe Ile Gly Val Ala Val Ala Pro Ala Asn Asp Ile Tyr Asn Glu Arg 
            100                 105                 110         


Glu Leu Leu Asn Ser Met Gly Ile Ser Gln Pro Thr Val Val Phe Val 
        115                 120                 125             


Ser Lys Lys Gly Leu Gln Lys Ile Leu Asn Val Gln Lys Lys Leu Pro 
    130                 135                 140                 


Ile Ile Gln Lys Ile Ile Ile Met Asp Ser Lys Thr Asp Tyr Gln Gly 
145                 150                 155                 160 


Phe Gln Ser Met Tyr Thr Phe Val Thr Ser His Leu Pro Pro Gly Phe 
                165                 170                 175     


Asn Glu Tyr Asp Phe Val Pro Glu Ser Phe Asp Arg Asp Lys Thr Ile 
            180                 185                 190         


Ala Leu Ile Met Asn Ser Ser Gly Ser Thr Gly Leu Pro Lys Gly Val 
        195                 200                 205             


Ala Leu Pro His Arg Thr Ala Cys Val Arg Phe Ser His Ala Arg Asp 
    210                 215                 220                 


Pro Ile Phe Gly Asn Gln Ile Ile Pro Asp Thr Ala Ile Leu Ser Val 
225                 230                 235                 240 


Val Pro Phe His His Gly Phe Gly Met Phe Thr Thr Leu Gly Tyr Leu 
                245                 250                 255     


Ile Cys Gly Phe Arg Val Val Leu Met Tyr Arg Phe Glu Glu Glu Leu 
            260                 265                 270         


Phe Leu Arg Ser Leu Gln Asp Tyr Lys Ile Gln Ser Ala Leu Leu Val 
        275                 280                 285             


Pro Thr Leu Phe Ser Phe Phe Ala Lys Ser Thr Leu Ile Asp Lys Tyr 
    290                 295                 300                 


Asp Leu Ser Asn Leu His Glu Ile Ala Ser Gly Gly Ala Pro Leu Ser 
305                 310                 315                 320 


Lys Glu Val Gly Glu Ala Val Ala Lys Arg Phe His Leu Pro Gly Ile 
                325                 330                 335     


Arg Gln Gly Tyr Gly Leu Thr Glu Thr Thr Ser Ala Ile Leu Ile Thr 
            340                 345                 350         


Pro Glu Gly Asp Asp Lys Pro Gly Ala Val Gly Lys Val Val Pro Phe 
        355                 360                 365             


Phe Glu Ala Lys Val Val Asp Leu Asp Thr Gly Lys Thr Leu Gly Val 
    370                 375                 380                 


Asn Gln Arg Gly Glu Leu Cys Val Arg Gly Pro Met Ile Met Ser Gly 
385                 390                 395                 400 


Tyr Val Asn Asn Pro Glu Ala Thr Asn Ala Leu Ile Asp Lys Asp Gly 
                405                 410                 415     


Trp Leu His Ser Gly Asp Ile Ala Tyr Trp Asp Glu Asp Glu His Phe 
            420                 425                 430         


Phe Ile Val Asp Arg Leu Lys Ser Leu Ile Lys Tyr Lys Gly Tyr Gln 
        435                 440                 445             


Val Ala Pro Ala Glu Leu Glu Ser Ile Leu Leu Gln His Pro Asn Ile 
    450                 455                 460                 


Phe Asp Ala Gly Val Ala Gly Leu Pro Asp Asp Asp Ala Gly Glu Leu 
465                 470                 475                 480 


Pro Ala Ala Val Val Val Leu Glu His Gly Lys Thr Met Thr Glu Lys 
                485                 490                 495     


Glu Ile Val Asp Tyr Val Ala Ser Gln Val Thr Thr Ala Lys Lys Leu 
            500                 505                 510         


Arg Gly Gly Val Val Phe Val Asp Glu Val Pro Lys Gly Leu Thr Gly 
        515                 520                 525             


Lys Leu Asp Ala Arg Lys Ile Arg Glu Ile Leu Ile Lys Ala Lys Lys 
    530                 535                 540                 


Gly Gly Lys Ile Ala Val Asn Ser His Gly Phe Pro Pro Glu Val Glu 
545                 550                 555                 560 


Glu Gln Ala Ala Gly Thr Leu Pro Met Ser Cys Ala Gln Glu Ser Gly 
                565                 570                 575     


Met Asp Arg His Pro Ala Ala Cys Ala Ser Ala Arg Ile Asn Val 
            580                 585                 590     


<210>  13
<211>  72
<212>  PRT
<213>  artificial sequence

<220>
<223>  VP16 transcription activation domain

<400>  13

Met Lys Leu Leu Ser Ser Ile Glu Gln Ala Cys Pro Lys Lys Lys Arg 
1               5                   10                  15      


Lys Val Asp Glu Phe Pro Gly Ile Ser Thr Ala Pro Pro Thr Asp Val 
            20                  25                  30          


Ser Leu Gly Asp Glu Leu His Leu Asp Gly Glu Asp Val Ala Met Ala 
        35                  40                  45              


His Ala Asp Ala Leu Asp Asp Phe Asp Leu Asp Met Leu Gly Asp Gly 
    50                  55                  60                  


Asp Ser Pro Gly Pro Gly Ser Pro 
65                  70          


<210>  14
<211>  76
<212>  PRT
<213>  Homo sapiens

<400>  14

Met Gln Ile Phe Val Lys Thr Leu Thr Gly Lys Thr Ile Thr Leu Glu 
1               5                   10                  15      


Val Glu Pro Ser Asp Thr Ile Glu Asn Val Lys Ala Lys Ile Gln Asp 
            20                  25                  30          


Lys Glu Gly Ile Pro Pro Asp Gln Gln Arg Leu Ile Phe Ala Gly Lys 
        35                  40                  45              


Gln Leu Glu Asp Gly Arg Thr Leu Ser Asp Tyr Asn Ile Gln Lys Glu 
    50                  55                  60                  


Ser Thr Leu His Leu Val Leu Arg Leu Arg Gly Gly 
65                  70                  75      


<210>  15
<211>  95
<212>  PRT
<213>  Homo sapiens

<400>  15

Met Ala Asp Glu Lys Pro Lys Glu Gly Val Lys Thr Glu Asn Asn Asp 
1               5                   10                  15      


His Ile Asn Leu Lys Val Ala Gly Gln Asp Gly Ser Val Val Gln Phe 
            20                  25                  30          


Lys Ile Lys Arg His Thr Pro Leu Ser Lys Leu Met Lys Ala Tyr Cys 
        35                  40                  45              


Glu Arg Gln Gly Leu Ser Met Arg Gln Ile Arg Phe Arg Phe Asp Gly 
    50                  55                  60                  


Gln Pro Ile Asn Glu Thr Asp Thr Pro Ala Gln Leu Glu Met Glu Asp 
65                  70                  75                  80  


Glu Asp Thr Ile Asp Val Phe Gln Gln Gln Thr Gly Gly Val Tyr 
                85                  90                  95  


<210>  16
<211>  117
<212>  PRT
<213>  Homo sapiens

<400>  16

Met Lys Trp Met Phe Lys Glu Asp His Ser Leu Glu His Arg Cys Val 
1               5                   10                  15      


Glu Ser Ala Lys Ile Arg Ala Lys Tyr Pro Asp Arg Val Pro Val Ile 
            20                  25                  30          


Val Glu Lys Val Ser Gly Ser Gln Ile Val Asp Ile Asp Lys Arg Lys 
        35                  40                  45              


Tyr Leu Val Pro Ser Asp Ile Thr Val Ala Gln Phe Met Trp Ile Ile 
    50                  55                  60                  


Arg Lys Arg Ile Gln Leu Pro Ser Glu Lys Ala Ile Phe Leu Phe Val 
65                  70                  75                  80  


Asp Lys Thr Val Pro Gln Ser Ser Leu Thr Met Gly Gln Leu Tyr Glu 
                85                  90                  95      


Lys Glu Lys Asp Glu Asp Gly Phe Leu Tyr Val Ala Tyr Ser Gly Glu 
            100                 105                 110         


Asn Thr Phe Gly Phe 
        115         


<210>  17
<211>  125
<212>  PRT
<213>  Homo sapiens

<400>  17

Met Pro Ser Glu Lys Thr Phe Lys Gln Arg Arg Thr Phe Glu Gln Arg 
1               5                   10                  15      


Val Glu Asp Val Arg Leu Ile Arg Glu Gln His Pro Thr Lys Ile Pro 
            20                  25                  30          


Val Ile Ile Glu Arg Tyr Lys Gly Glu Lys Gln Leu Pro Val Leu Asp 
        35                  40                  45              


Lys Thr Lys Phe Leu Val Pro Asp His Val Asn Met Ser Glu Leu Ile 
    50                  55                  60                  


Lys Ile Ile Arg Arg Arg Leu Gln Leu Asn Ala Asn Gln Ala Phe Phe 
65                  70                  75                  80  


Leu Leu Val Asn Gly His Ser Met Val Ser Val Ser Thr Pro Ile Ser 
                85                  90                  95      


Glu Val Tyr Glu Ser Glu Lys Asp Glu Asp Gly Phe Leu Tyr Met Val 
            100                 105                 110         


Tyr Ala Ser Gln Glu Thr Phe Gly Met Lys Leu Ser Val 
        115                 120                 125 


<210>  18
<211>  90
<212>  PRT
<213>  Mus musculus

<400>  18

Gly Met Gln Leu Glu Asp Leu Arg Gln Gln Leu Gln Gln Ala Glu Glu 
1               5                   10                  15      


Ala Leu Val Ala Lys Gln Glu Leu Ile Asp Lys Leu Lys Glu Glu Ala 
            20                  25                  30          


Glu Gln His Lys Ile Val Met Glu Thr Val Pro Val Leu Lys Ala Gln 
        35                  40                  45              


Ala Asp Ile Tyr Lys Ala Asp Phe Gln Ala Glu Arg His Ala Arg Glu 
    50                  55                  60                  


Lys Leu Val Glu Lys Lys Glu Tyr Leu Gln Glu Gln Leu Glu Gln Leu 
65                  70                  75                  80  


Gln Arg Glu Phe Asn Lys Leu Lys Val Gly 
                85                  90  


<210>  19
<211>  92
<212>  PRT
<213>  artificial sequence

<220>
<223>  F312A mutant of UBAN-domain of human NEMO

<400>  19

Lys Ser Ser Val Val Gly Ser Glu Arg Lys Arg Gly Met Gln Leu Glu 
1               5                   10                  15      


Asp Leu Lys Gln Gln Leu Gln Gln Ala Glu Glu Ala Leu Val Ala Lys 
            20                  25                  30          


Gln Glu Val Ile Asp Lys Leu Lys Glu Glu Ala Glu Gln His Lys Ile 
        35                  40                  45              


Val Met Glu Thr Val Pro Val Leu Lys Ala Gln Ala Asp Ile Tyr Lys 
    50                  55                  60                  


Ala Asp Ala Gln Ala Glu Arg Gln Ala Arg Glu Lys Leu Ala Glu Lys 
65                  70                  75                  80  


Lys Glu Leu Leu Gln Glu Gln Leu Glu Gln Leu Gln 
                85                  90          


<210>  20
<211>  636
<212>  PRT
<213>  Homo sapiens

<400>  20

Met Glu Gly Arg Gly Pro Tyr Arg Ile Tyr Asp Pro Gly Gly Ser Val 
1               5                   10                  15      


Pro Ser Gly Glu Ala Ser Ala Ala Phe Glu Arg Leu Val Lys Glu Asn 
            20                  25                  30          


Ser Arg Leu Lys Glu Lys Met Gln Gly Ile Lys Met Leu Gly Glu Leu 
        35                  40                  45              


Leu Glu Glu Ser Gln Met Glu Ala Thr Arg Leu Arg Gln Lys Ala Glu 
    50                  55                  60                  


Glu Leu Val Lys Asp Asn Glu Leu Leu Pro Pro Pro Ser Pro Ser Leu 
65                  70                  75                  80  


Gly Ser Phe Asp Pro Leu Ala Glu Leu Thr Gly Lys Asp Ser Asn Val 
                85                  90                  95      


Thr Ala Ser Pro Thr Ala Pro Ala Cys Pro Ser Asp Lys Pro Ala Pro 
            100                 105                 110         


Val Gln Lys Pro Pro Ser Ser Gly Thr Ser Ser Glu Phe Glu Val Val 
        115                 120                 125             


Thr Pro Glu Glu Gln Asn Ser Pro Glu Ser Ser Ser His Ala Asn Ala 
    130                 135                 140                 


Met Ala Leu Gly Pro Leu Pro Arg Glu Asp Gly Asn Leu Met Leu His 
145                 150                 155                 160 


Leu Gln Arg Leu Glu Thr Thr Leu Ser Val Cys Ala Glu Glu Pro Asp 
                165                 170                 175     


His Gly Gln Leu Phe Thr His Leu Gly Arg Met Ala Leu Glu Phe Asn 
            180                 185                 190         


Arg Leu Ala Ser Lys Val His Lys Asn Glu Gln Arg Thr Ser Ile Leu 
        195                 200                 205             


Gln Thr Leu Cys Glu Gln Leu Arg Lys Glu Asn Glu Ala Leu Lys Ala 
    210                 215                 220                 


Lys Leu Asp Lys Gly Leu Glu Gln Arg Asp Gln Ala Ala Glu Arg Leu 
225                 230                 235                 240 


Arg Glu Glu Asn Leu Glu Leu Lys Lys Leu Leu Met Ser Asn Gly Asn 
                245                 250                 255     


Lys Glu Gly Ala Ser Gly Arg Pro Gly Ser Pro Lys Met Glu Gly Thr 
            260                 265                 270         


Gly Lys Lys Ala Val Ala Gly Gln Gln Gln Ala Ser Val Thr Ala Gly 
        275                 280                 285             


Lys Val Pro Glu Val Val Ala Leu Gly Ala Ala Glu Lys Lys Val Lys 
    290                 295                 300                 


Met Leu Glu Gln Gln Arg Ser Glu Leu Leu Glu Val Asn Lys Gln Trp 
305                 310                 315                 320 


Asp Gln His Phe Arg Ser Met Lys Gln Gln Tyr Glu Gln Lys Ile Thr 
                325                 330                 335     


Glu Leu Arg Gln Lys Leu Ala Asp Leu Gln Lys Gln Val Thr Asp Leu 
            340                 345                 350         


Glu Ala Glu Arg Glu Gln Lys Gln Arg Asp Phe Asp Arg Lys Leu Leu 
        355                 360                 365             


Leu Ala Lys Ser Lys Ile Glu Met Glu Glu Thr Asp Lys Glu Gln Leu 
    370                 375                 380                 


Thr Ala Glu Ala Lys Glu Leu Arg Gln Lys Val Lys Tyr Leu Gln Asp 
385                 390                 395                 400 


Gln Leu Ser Pro Leu Thr Arg Gln Arg Glu Tyr Gln Glu Lys Glu Ile 
                405                 410                 415     


Gln Arg Leu Asn Lys Ala Leu Glu Glu Ala Leu Ser Ile Gln Thr Pro 
            420                 425                 430         


Pro Ser Ser Pro Pro Thr Ala Phe Gly Ser Pro Glu Gly Ala Gly Ala 
        435                 440                 445             


Leu Leu Arg Lys Gln Glu Leu Val Thr Gln Asn Glu Leu Leu Lys Gln 
    450                 455                 460                 


Gln Val Lys Ile Phe Glu Glu Asp Phe Gln Arg Glu Arg Ser Asp Arg 
465                 470                 475                 480 


Glu Arg Met Asn Glu Glu Lys Glu Glu Leu Lys Lys Gln Val Glu Lys 
                485                 490                 495     


Leu Gln Ala Gln Val Thr Leu Ser Asn Ala Gln Leu Lys Ala Phe Lys 
            500                 505                 510         


Asp Glu Glu Lys Ala Arg Glu Ala Leu Arg Gln Gln Lys Arg Lys Ala 
        515                 520                 525             


Lys Ala Ser Gly Glu Arg Tyr His Val Glu Pro His Pro Glu His Leu 
    530                 535                 540                 


Cys Gly Ala Tyr Pro Tyr Ala Tyr Pro Pro Met Pro Ala Met Val Pro 
545                 550                 555                 560 


His His Gly Phe Glu Asp Trp Ser Gln Ile Arg Tyr Pro Pro Pro Pro 
                565                 570                 575     


Met Ala Met Glu His Pro Pro Pro Leu Pro Asn Ser Arg Leu Phe His 
            580                 585                 590         


Leu Pro Glu Tyr Thr Trp Arg Leu Pro Cys Gly Gly Val Arg Asn Pro 
        595                 600                 605             


Asn Gln Ser Ser Gln Val Met Asp Pro Pro Thr Ala Arg Pro Thr Glu 
    610                 615                 620                 


Pro Glu Ser Pro Lys Asn Asp Arg Glu Gly Pro Gln 
625                 630                 635     


<210>  21
<211>  90
<212>  PRT
<213>  Mus musculus

<400>  21

Gly Met Gln Leu Glu Asp Leu Arg Gln Gln Leu Gln Gln Ala Glu Glu 
1               5                   10                  15      


Ala Leu Val Ala Lys Gln Glu Leu Ile Asp Lys Leu Lys Glu Glu Ala 
            20                  25                  30          


Glu Gln His Lys Ile Val Met Glu Thr Val Pro Ala Leu Lys Ala Gln 
        35                  40                  45              


Ala Asp Ile Ala Ala Ala Asp Phe Gln Ala Glu Arg His Ala Arg Glu 
    50                  55                  60                  


Lys Leu Val Glu Lys Lys Glu Tyr Leu Gln Glu Gln Leu Glu Gln Leu 
65                  70                  75                  80  


Gln Arg Glu Phe Asn Lys Leu Lys Val Gly 
                85                  90  


<210>  22
<211>  61
<212>  PRT
<213>  Homo sapiens

<400>  22

Gln Glu Glu Asp Leu Glu Thr Met Thr Ile Leu Arg Ala Gln Met Glu 
1               5                   10                  15      


Val Tyr Cys Ser Asp Phe His Ala Glu Arg Ala Ala Arg Glu Lys Ile 
            20                  25                  30          


His Glu Glu Lys Glu Gln Leu Ala Leu Gln Leu Ala Val Leu Leu Lys 
        35                  40                  45              


Glu Asn Asp Ala Phe Glu Asp Gly Gly Arg Gln Ser Leu 
    50                  55                  60      


<210>  23
<211>  124
<212>  PRT
<213>  Homo sapiens

<400>  23

Gln Glu Glu Asp Leu Glu Thr Met Thr Ile Leu Arg Ala Gln Met Glu 
1               5                   10                  15      


Val Tyr Cys Ser Asp Phe His Ala Glu Arg Ala Ala Arg Glu Lys Ile 
            20                  25                  30          


His Glu Glu Lys Glu Gln Leu Ala Leu Gln Leu Ala Val Leu Leu Lys 
        35                  40                  45              


Glu Asn Asp Ala Phe Glu Asp Gly Gly Arg Gln Ser Leu Met Glu Met 
    50                  55                  60                  


Gln Ser Arg His Gly Ala Arg Thr Ser Asp Ser Asp Gln Gln Ala Tyr 
65                  70                  75                  80  


Leu Val Gln Arg Gly Ala Glu Asp Arg Asp Trp Arg Gln Gln Arg Asn 
                85                  90                  95      


Ile Pro Ile His Ser Cys Pro Lys Cys Gly Glu Val Leu Pro Asp Ile 
            100                 105                 110         


Asp Thr Leu Gln Ile His Val Met Asp Cys Ile Ile 
        115                 120                 


<210>  24
<211>  61
<212>  PRT
<213>  Homo sapiens

<400>  24

Gln Glu Glu Asp Leu Glu Thr Met Thr Ile Leu Arg Ala Gln Met Glu 
1               5                   10                  15      


Val Tyr Cys Ser Asn Phe His Ala Glu Arg Ala Ala Arg Glu Lys Ile 
            20                  25                  30          


His Glu Glu Lys Glu Gln Leu Ala Leu Gln Leu Ala Val Leu Leu Lys 
        35                  40                  45              


Glu Asn Asp Ala Phe Glu Asp Gly Gly Arg Gln Ser Leu 
    50                  55                  60      


<210>  25
<211>  61
<212>  PRT
<213>  Mus musculus

<400>  25

Lys Gln Glu Leu Val Thr Gln Asn Glu Leu Leu Lys Gln Gln Val Lys 
1               5                   10                  15      


Ile Phe Glu Glu Asp Phe Gln Arg Glu Arg Ser Asp Arg Glu Arg Met 
            20                  25                  30          


Asn Glu Glu Lys Glu Glu Leu Lys Lys Gln Val Glu Lys Leu Gln Ala 
        35                  40                  45              


Gln Val Thr Leu Thr Asn Ala Gln Leu Lys Thr Leu Lys 
    50                  55                  60      


<210>  26
<211>  61
<212>  PRT
<213>  Mus musculus

<400>  26

Lys Gln Glu Leu Val Thr Gln Asn Glu Leu Leu Lys Gln Gln Val Lys 
1               5                   10                  15      


Ile Phe Glu Glu Ala Phe Gln Arg Glu Arg Ser Asp Arg Glu Arg Met 
            20                  25                  30          


Asn Glu Glu Lys Glu Glu Leu Lys Lys Gln Val Glu Lys Leu Gln Ala 
        35                  40                  45              


Gln Val Thr Leu Thr Asn Ala Gln Leu Lys Thr Leu Lys 
    50                  55                  60      


<210>  27
<211>  61
<212>  PRT
<213>  Mus musculus

<400>  27

Lys Gln Glu Leu Val Thr Gln Asn Glu Leu Leu Lys Gln Gln Val Lys 
1               5                   10                  15      


Ile Phe Glu Glu Asn Ala Gln Arg Glu Arg Ser Asp Arg Glu Arg Met 
            20                  25                  30          


Asn Glu Glu Lys Glu Glu Leu Lys Lys Gln Val Glu Lys Leu Gln Ala 
        35                  40                  45              


Gln Val Thr Leu Thr Asn Ala Gln Leu Lys Thr Leu Lys 
    50                  55                  60      


<210>  28
<211>  510
<212>  PRT
<213>  Homo sapiens

<400>  28

Met Asp Glu Lys Thr Lys Lys Ala Glu Glu Met Ala Leu Ser Leu Thr 
1               5                   10                  15      


Arg Ala Val Ala Gly Gly Asp Glu Gln Val Ala Met Lys Cys Ala Ile 
            20                  25                  30          


Trp Leu Ala Glu Gln Arg Val Pro Leu Ser Val Gln Leu Lys Pro Glu 
        35                  40                  45              


Val Ser Pro Thr Gln Asp Ile Arg Leu Trp Val Ser Val Glu Asp Ala 
    50                  55                  60                  


Gln Met His Thr Val Thr Ile Trp Leu Thr Val Arg Pro Asp Met Thr 
65                  70                  75                  80  


Val Ala Ser Leu Lys Asp Met Val Phe Leu Asp Tyr Gly Phe Pro Pro 
                85                  90                  95      


Val Leu Gln Gln Trp Val Ile Gly Gln Arg Leu Ala Arg Asp Gln Glu 
            100                 105                 110         


Thr Leu His Ser His Gly Val Arg Gln Asn Gly Asp Ser Ala Tyr Leu 
        115                 120                 125             


Tyr Leu Leu Ser Ala Arg Asn Thr Ser Leu Asn Pro Gln Glu Leu Gln 
    130                 135                 140                 


Arg Glu Arg Gln Leu Arg Met Leu Glu Asp Leu Gly Phe Lys Asp Leu 
145                 150                 155                 160 


Thr Leu Gln Pro Arg Gly Pro Leu Glu Pro Gly Pro Pro Lys Pro Gly 
                165                 170                 175     


Val Pro Gln Glu Pro Gly Arg Gly Gln Pro Asp Ala Val Pro Glu Pro 
            180                 185                 190         


Pro Pro Val Gly Trp Gln Cys Pro Gly Cys Thr Phe Ile Asn Lys Pro 
        195                 200                 205             


Thr Arg Pro Gly Cys Glu Met Cys Cys Arg Ala Arg Pro Glu Ala Tyr 
    210                 215                 220                 


Gln Val Pro Ala Ser Tyr Gln Pro Asp Glu Glu Glu Arg Ala Arg Leu 
225                 230                 235                 240 


Ala Gly Glu Glu Glu Ala Leu Arg Gln Tyr Gln Gln Arg Lys Gln Gln 
                245                 250                 255     


Gln Gln Glu Gly Asn Tyr Leu Gln His Val Gln Leu Asp Gln Arg Ser 
            260                 265                 270         


Leu Val Leu Asn Thr Glu Pro Ala Glu Cys Pro Val Cys Tyr Ser Val 
        275                 280                 285             


Leu Ala Pro Gly Glu Ala Val Val Leu Arg Glu Cys Leu His Thr Phe 
    290                 295                 300                 


Cys Arg Glu Cys Leu Gln Gly Thr Ile Arg Asn Ser Gln Glu Ala Glu 
305                 310                 315                 320 


Val Ser Cys Pro Phe Ile Asp Asn Thr Tyr Ser Cys Ser Gly Lys Leu 
                325                 330                 335     


Leu Glu Arg Glu Ile Lys Ala Leu Leu Thr Pro Glu Asp Tyr Gln Arg 
            340                 345                 350         


Phe Leu Asp Leu Gly Ile Ser Ile Ala Glu Asn Arg Ser Ala Phe Ser 
        355                 360                 365             


Tyr His Cys Lys Thr Pro Asp Cys Lys Gly Trp Cys Phe Phe Glu Asp 
    370                 375                 380                 


Asp Val Asn Glu Phe Thr Cys Pro Val Cys Phe His Val Asn Cys Leu 
385                 390                 395                 400 


Leu Cys Lys Ala Ile His Glu Gln Met Asn Cys Lys Glu Tyr Gln Glu 
                405                 410                 415     


Asp Leu Ala Leu Arg Ala Gln Asn Asp Val Ala Ala Arg Gln Thr Thr 
            420                 425                 430         


Glu Met Leu Lys Val Met Leu Gln Gln Gly Glu Ala Met Arg Cys Pro 
        435                 440                 445             


Gln Cys Gln Ile Val Val Gln Lys Lys Asp Gly Cys Asp Trp Ile Arg 
    450                 455                 460                 


Cys Thr Val Cys His Thr Glu Ile Cys Trp Val Thr Lys Gly Pro Arg 
465                 470                 475                 480 


Trp Gly Pro Gly Gly Pro Gly Asp Thr Ser Gly Gly Cys Arg Cys Arg 
                485                 490                 495     


Val Asn Gly Ile Pro Cys His Pro Ser Cys Gln Asn Cys His 
            500                 505                 510 


<210>  29
<211>  1072
<212>  PRT
<213>  Homo sapiens

<400>  29

Met Pro Gly Glu Glu Glu Glu Arg Ala Phe Leu Val Ala Arg Glu Glu 
1               5                   10                  15      


Leu Ala Ser Ala Leu Arg Arg Asp Ser Gly Gln Ala Phe Ser Leu Glu 
            20                  25                  30          


Gln Leu Arg Pro Leu Leu Ala Ser Ser Leu Pro Leu Ala Ala Arg Tyr 
        35                  40                  45              


Leu Gln Leu Asp Ala Ala Arg Leu Val Arg Cys Asn Ala His Gly Glu 
    50                  55                  60                  


Pro Arg Asn Tyr Leu Asn Thr Leu Ser Thr Ala Leu Asn Ile Leu Glu 
65                  70                  75                  80  


Lys Tyr Gly Arg Asn Leu Leu Ser Pro Gln Arg Pro Arg Tyr Trp Arg 
                85                  90                  95      


Gly Val Lys Phe Asn Asn Pro Val Phe Arg Ser Thr Val Asp Ala Val 
            100                 105                 110         


Gln Gly Gly Arg Asp Val Leu Arg Leu Tyr Gly Tyr Thr Glu Glu Gln 
        115                 120                 125             


Pro Asp Gly Leu Ser Phe Pro Glu Gly Gln Glu Glu Pro Asp Glu His 
    130                 135                 140                 


Gln Val Ala Thr Val Thr Leu Glu Val Leu Leu Leu Arg Thr Glu Leu 
145                 150                 155                 160 


Ser Leu Leu Leu Gln Asn Thr His Pro Arg Gln Gln Ala Leu Glu Gln 
                165                 170                 175     


Leu Leu Glu Asp Lys Val Glu Asp Asp Met Leu Gln Leu Ser Glu Phe 
            180                 185                 190         


Asp Pro Leu Leu Arg Glu Ile Ala Pro Gly Pro Leu Thr Thr Pro Ser 
        195                 200                 205             


Val Pro Gly Ser Thr Pro Gly Pro Cys Phe Leu Cys Gly Ser Ala Pro 
    210                 215                 220                 


Gly Thr Leu His Cys Pro Ser Cys Lys Gln Ala Leu Cys Pro Ala Cys 
225                 230                 235                 240 


Asp His Leu Phe His Gly His Pro Ser Arg Ala His His Leu Arg Gln 
                245                 250                 255     


Thr Leu Pro Gly Val Leu Gln Gly Thr His Leu Ser Pro Ser Leu Pro 
            260                 265                 270         


Ala Ser Ala Gln Pro Arg Pro Gln Ser Thr Ser Leu Leu Ala Leu Gly 
        275                 280                 285             


Asp Ser Ser Leu Ser Ser Pro Asn Pro Ala Ser Ala His Leu Pro Trp 
    290                 295                 300                 


His Cys Ala Ala Cys Ala Met Leu Asn Glu Pro Trp Ala Val Leu Cys 
305                 310                 315                 320 


Val Ala Cys Asp Arg Pro Arg Gly Cys Lys Gly Leu Gly Leu Gly Thr 
                325                 330                 335     


Glu Gly Pro Gln Gly Thr Gly Gly Leu Glu Pro Asp Leu Ala Arg Gly 
            340                 345                 350         


Arg Trp Ala Cys Gln Ser Cys Thr Phe Glu Asn Glu Ala Ala Ala Val 
        355                 360                 365             


Leu Cys Ser Ile Cys Glu Arg Pro Arg Leu Ala Gln Pro Pro Ser Leu 
    370                 375                 380                 


Val Val Asp Ser Arg Asp Ala Gly Ile Cys Leu Gln Pro Leu Gln Gln 
385                 390                 395                 400 


Gly Asp Ala Leu Leu Ala Ser Ala Gln Ser Gln Val Trp Tyr Cys Ile 
                405                 410                 415     


His Cys Thr Phe Cys Asn Ser Ser Pro Gly Trp Val Cys Val Met Cys 
            420                 425                 430         


Asn Arg Thr Ser Ser Pro Ile Pro Ala Gln His Ala Pro Arg Pro Tyr 
        435                 440                 445             


Ala Ser Ser Leu Glu Lys Gly Pro Pro Lys Pro Gly Pro Pro Arg Arg 
    450                 455                 460                 


Leu Ser Ala Pro Leu Pro Ser Ser Cys Gly Asp Pro Glu Lys Gln Arg 
465                 470                 475                 480 


Gln Asp Lys Met Arg Glu Glu Gly Leu Gln Leu Val Ser Met Ile Arg 
                485                 490                 495     


Glu Gly Glu Ala Ala Gly Ala Cys Pro Glu Glu Ile Phe Ser Ala Leu 
            500                 505                 510         


Gln Tyr Ser Gly Thr Glu Val Pro Leu Gln Trp Leu Arg Ser Glu Leu 
        515                 520                 525             


Pro Tyr Val Leu Glu Met Val Ala Glu Leu Ala Gly Gln Gln Asp Pro 
    530                 535                 540                 


Gly Leu Gly Ala Phe Ser Cys Gln Glu Ala Arg Arg Ala Trp Leu Asp 
545                 550                 555                 560 


Arg His Gly Asn Leu Asp Glu Ala Val Glu Glu Cys Val Arg Thr Arg 
                565                 570                 575     


Arg Arg Lys Val Gln Glu Leu Gln Ser Leu Gly Phe Gly Pro Glu Glu 
            580                 585                 590         


Gly Ser Leu Gln Ala Leu Phe Gln His Gly Gly Asp Val Ser Arg Ala 
        595                 600                 605             


Leu Thr Glu Leu Gln Arg Gln Arg Leu Glu Pro Phe Arg Gln Arg Leu 
    610                 615                 620                 


Trp Asp Ser Gly Pro Glu Pro Thr Pro Ser Trp Asp Gly Pro Asp Lys 
625                 630                 635                 640 


Gln Ser Leu Val Arg Arg Leu Leu Ala Val Tyr Ala Leu Pro Ser Trp 
                645                 650                 655     


Gly Arg Ala Glu Leu Ala Leu Ser Leu Leu Gln Glu Thr Pro Arg Asn 
            660                 665                 670         


Tyr Glu Leu Gly Asp Val Val Glu Ala Val Arg His Ser Gln Asp Arg 
        675                 680                 685             


Ala Phe Leu Arg Arg Leu Leu Ala Gln Glu Cys Ala Val Cys Gly Trp 
    690                 695                 700                 


Ala Leu Pro His Asn Arg Met Gln Ala Leu Thr Ser Cys Glu Cys Thr 
705                 710                 715                 720 


Ile Cys Pro Asp Cys Phe Arg Gln His Phe Thr Ile Ala Leu Lys Glu 
                725                 730                 735     


Lys His Ile Thr Asp Met Val Cys Pro Ala Cys Gly Arg Pro Asp Leu 
            740                 745                 750         


Thr Asp Asp Thr Gln Leu Leu Ser Tyr Phe Ser Thr Leu Asp Ile Gln 
        755                 760                 765             


Leu Arg Glu Ser Leu Glu Pro Asp Ala Tyr Ala Leu Phe His Lys Lys 
    770                 775                 780                 


Leu Thr Glu Gly Val Leu Met Arg Asp Pro Lys Phe Leu Trp Cys Ala 
785                 790                 795                 800 


Gln Cys Ser Phe Gly Phe Ile Tyr Glu Arg Glu Gln Leu Glu Ala Thr 
                805                 810                 815     


Cys Pro Gln Cys His Gln Thr Phe Cys Val Arg Cys Lys Arg Gln Trp 
            820                 825                 830         


Glu Glu Gln His Arg Gly Arg Ser Cys Glu Asp Phe Gln Asn Trp Lys 
        835                 840                 845             


Arg Met Asn Asp Pro Glu Tyr Gln Ala Gln Gly Leu Ala Met Tyr Leu 
    850                 855                 860                 


Gln Glu Asn Gly Ile Asp Cys Pro Lys Cys Lys Phe Ser Tyr Ala Leu 
865                 870                 875                 880 


Ala Arg Gly Gly Cys Met His Phe His Cys Thr Gln Cys Arg His Gln 
                885                 890                 895     


Phe Cys Ser Gly Cys Tyr Asn Ala Phe Tyr Ala Lys Asn Lys Cys Pro 
            900                 905                 910         


Glu Pro Asn Cys Arg Val Lys Lys Ser Leu His Gly His His Pro Arg 
        915                 920                 925             


Asp Cys Leu Phe Tyr Leu Arg Asp Trp Thr Ala Leu Arg Leu Gln Lys 
    930                 935                 940                 


Leu Leu Gln Asp Asn Asn Val Met Phe Asn Thr Glu Pro Pro Ala Gly 
945                 950                 955                 960 


Ala Arg Ala Val Pro Gly Gly Gly Cys Arg Val Ile Glu Gln Lys Glu 
                965                 970                 975     


Val Pro Asn Gly Leu Arg Asp Glu Ala Cys Gly Lys Glu Thr Pro Ala 
            980                 985                 990         


Gly Tyr Ala Gly Leu Cys Gln Ala  His Tyr Lys Glu Tyr  Leu Val Ser 
        995                 1000                 1005             


Leu Ile  Asn Ala His Ser Leu  Asp Pro Ala Thr Leu  Tyr Glu Val 
    1010                 1015                 1020             


Glu Glu  Leu Glu Thr Ala Thr  Glu Arg Tyr Leu His  Val Arg Pro 
    1025                 1030                 1035             


Gln Pro  Leu Ala Gly Glu Asp  Pro Pro Ala Tyr Gln  Ala Arg Leu 
    1040                 1045                 1050             


Leu Gln  Lys Leu Thr Glu Glu  Val Pro Leu Gly Gln  Ser Ile Pro 
    1055                 1060                 1065             


Arg Arg  Arg Lys 
    1070         


<210>  30
<211>  565
<212>  PRT
<213>  Homo sapiens

<400>  30

Met Pro Gln Ala Ser Glu His Arg Leu Gly Arg Thr Arg Glu Pro Pro 
1               5                   10                  15      


Val Asn Ile Gln Pro Arg Val Gly Ser Lys Leu Pro Phe Ala Pro Arg 
            20                  25                  30          


Ala Arg Ser Lys Glu Arg Arg Asn Pro Ala Ser Gly Pro Asn Pro Met 
        35                  40                  45              


Leu Arg Pro Leu Pro Pro Arg Pro Gly Leu Pro Asp Glu Arg Leu Lys 
    50                  55                  60                  


Lys Leu Glu Leu Gly Arg Gly Arg Thr Ser Gly Pro Arg Pro Arg Gly 
65                  70                  75                  80  


Pro Leu Arg Ala Asp His Gly Val Pro Leu Pro Gly Ser Pro Pro Pro 
                85                  90                  95      


Thr Val Ala Leu Pro Leu Pro Ser Arg Thr Asn Leu Ala Arg Ser Lys 
            100                 105                 110         


Ser Val Ser Ser Gly Asp Leu Arg Pro Met Gly Ile Ala Leu Gly Gly 
        115                 120                 125             


His Arg Gly Thr Gly Glu Leu Gly Ala Ala Leu Ser Arg Leu Ala Leu 
    130                 135                 140                 


Arg Pro Glu Pro Pro Thr Leu Arg Arg Ser Thr Ser Leu Arg Arg Leu 
145                 150                 155                 160 


Gly Gly Phe Pro Gly Pro Pro Thr Leu Phe Ser Ile Arg Thr Glu Pro 
                165                 170                 175     


Pro Ala Ser His Gly Ser Phe His Met Ile Ser Ala Arg Ser Ser Glu 
            180                 185                 190         


Pro Phe Tyr Ser Asp Asp Lys Met Ala His His Thr Leu Leu Leu Gly 
        195                 200                 205             


Ser Gly His Val Gly Leu Arg Asn Leu Gly Asn Thr Cys Phe Leu Asn 
    210                 215                 220                 


Ala Val Leu Gln Cys Leu Ser Ser Thr Arg Pro Leu Arg Asp Phe Cys 
225                 230                 235                 240 


Leu Arg Arg Asp Phe Arg Gln Glu Val Pro Gly Gly Gly Arg Ala Gln 
                245                 250                 255     


Glu Leu Thr Glu Ala Phe Ala Asp Val Ile Gly Ala Leu Trp His Pro 
            260                 265                 270         


Asp Ser Cys Glu Ala Val Asn Pro Thr Arg Phe Arg Ala Val Phe Gln 
        275                 280                 285             


Lys Tyr Val Pro Ser Phe Ser Gly Tyr Ser Gln Gln Asp Ala Gln Glu 
    290                 295                 300                 


Phe Leu Lys Leu Leu Met Glu Arg Leu His Leu Glu Ile Asn Arg Arg 
305                 310                 315                 320 


Gly Arg Arg Ala Pro Pro Ile Leu Ala Asn Gly Pro Val Pro Ser Pro 
                325                 330                 335     


Pro Arg Arg Gly Gly Ala Leu Leu Glu Glu Pro Glu Leu Ser Asp Asp 
            340                 345                 350         


Asp Arg Ala Asn Leu Met Trp Lys Arg Tyr Leu Glu Arg Glu Asp Ser 
        355                 360                 365             


Lys Ile Val Asp Leu Phe Val Gly Gln Leu Lys Ser Cys Leu Lys Cys 
    370                 375                 380                 


Gln Ala Cys Gly Tyr Arg Ser Thr Thr Phe Glu Val Phe Cys Asp Leu 
385                 390                 395                 400 


Ser Leu Pro Ile Pro Lys Lys Gly Phe Ala Gly Gly Lys Val Ser Leu 
                405                 410                 415     


Arg Asp Cys Phe Asn Leu Phe Thr Lys Glu Glu Glu Leu Glu Ser Glu 
            420                 425                 430         


Asn Ala Pro Val Cys Asp Arg Cys Arg Gln Lys Thr Arg Ser Thr Lys 
        435                 440                 445             


Lys Leu Thr Val Gln Arg Phe Pro Arg Ile Leu Val Leu His Leu Asn 
    450                 455                 460                 


Arg Phe Ser Ala Ser Arg Gly Ser Ile Lys Lys Ser Ser Val Gly Val 
465                 470                 475                 480 


Asp Phe Pro Leu Gln Arg Leu Ser Leu Gly Asp Phe Ala Ser Asp Lys 
                485                 490                 495     


Ala Gly Ser Pro Val Tyr Gln Leu Tyr Ala Leu Cys Asn His Ser Gly 
            500                 505                 510         


Ser Val His Tyr Gly His Tyr Thr Ala Leu Cys Arg Cys Gln Thr Gly 
        515                 520                 525             


Trp His Val Tyr Asn Asp Ser Arg Val Ser Pro Val Ser Glu Asn Gln 
    530                 535                 540                 


Val Ala Ser Ser Glu Gly Tyr Val Leu Phe Tyr Gln Leu Met Gln Glu 
545                 550                 555                 560 


Pro Pro Arg Cys Leu 
                565 


<210>  31
<211>  1102
<212>  PRT
<213>  Homo sapiens

<400>  31

Met Asn His Gln Gln Gln Gln Gln Gln Gln Lys Ala Gly Glu Gln Gln 
1               5                   10                  15      


Leu Ser Glu Pro Glu Asp Met Glu Met Glu Ala Gly Asp Thr Asp Asp 
            20                  25                  30          


Pro Pro Arg Ile Thr Gln Asn Pro Val Ile Asn Gly Asn Val Ala Leu 
        35                  40                  45              


Ser Asp Gly His Asn Thr Ala Glu Glu Asp Met Glu Asp Asp Thr Ser 
    50                  55                  60                  


Trp Arg Ser Glu Ala Thr Phe Gln Phe Thr Val Glu Arg Phe Ser Arg 
65                  70                  75                  80  


Leu Ser Glu Ser Val Leu Ser Pro Pro Cys Phe Val Arg Asn Leu Pro 
                85                  90                  95      


Trp Lys Ile Met Val Met Pro Arg Phe Tyr Pro Asp Arg Pro His Gln 
            100                 105                 110         


Lys Ser Val Gly Phe Phe Leu Gln Cys Asn Ala Glu Ser Asp Ser Thr 
        115                 120                 125             


Ser Trp Ser Cys His Ala Gln Ala Val Leu Lys Ile Ile Asn Tyr Arg 
    130                 135                 140                 


Asp Asp Glu Lys Ser Phe Ser Arg Arg Ile Ser His Leu Phe Phe His 
145                 150                 155                 160 


Lys Glu Asn Asp Trp Gly Phe Ser Asn Phe Met Ala Trp Ser Glu Val 
                165                 170                 175     


Thr Asp Pro Glu Lys Gly Phe Ile Asp Asp Asp Lys Val Thr Phe Glu 
            180                 185                 190         


Val Phe Val Gln Ala Asp Ala Pro His Gly Val Ala Trp Asp Ser Lys 
        195                 200                 205             


Lys His Thr Gly Tyr Val Gly Leu Lys Asn Gln Gly Ala Thr Cys Tyr 
    210                 215                 220                 


Met Asn Ser Leu Leu Gln Thr Leu Phe Phe Thr Asn Gln Leu Arg Lys 
225                 230                 235                 240 


Ala Val Tyr Met Met Pro Thr Glu Gly Asp Asp Ser Ser Lys Ser Val 
                245                 250                 255     


Pro Leu Ala Leu Gln Arg Val Phe Tyr Glu Leu Gln His Ser Asp Lys 
            260                 265                 270         


Pro Val Gly Thr Lys Lys Leu Thr Lys Ser Phe Gly Trp Glu Thr Leu 
        275                 280                 285             


Asp Ser Phe Met Gln His Asp Val Gln Glu Leu Cys Arg Val Leu Leu 
    290                 295                 300                 


Asp Asn Val Glu Asn Lys Met Lys Gly Thr Cys Val Glu Gly Thr Ile 
305                 310                 315                 320 


Pro Lys Leu Phe Arg Gly Lys Met Val Ser Tyr Ile Gln Cys Lys Glu 
                325                 330                 335     


Val Asp Tyr Arg Ser Asp Arg Arg Glu Asp Tyr Tyr Asp Ile Gln Leu 
            340                 345                 350         


Ser Ile Lys Gly Lys Lys Asn Ile Phe Glu Ser Phe Val Asp Tyr Val 
        355                 360                 365             


Ala Val Glu Gln Leu Asp Gly Asp Asn Lys Tyr Asp Ala Gly Glu His 
    370                 375                 380                 


Gly Leu Gln Glu Ala Glu Lys Gly Val Lys Phe Leu Thr Leu Pro Pro 
385                 390                 395                 400 


Val Leu His Leu Gln Leu Met Arg Phe Met Tyr Asp Pro Gln Thr Asp 
                405                 410                 415     


Gln Asn Ile Lys Ile Asn Asp Arg Phe Glu Phe Pro Glu Gln Leu Pro 
            420                 425                 430         


Leu Asp Glu Phe Leu Gln Lys Thr Asp Pro Lys Asp Pro Ala Asn Tyr 
        435                 440                 445             


Ile Leu His Ala Val Leu Val His Ser Gly Asp Asn His Gly Gly His 
    450                 455                 460                 


Tyr Val Val Tyr Leu Asn Pro Lys Gly Asp Gly Lys Trp Cys Lys Phe 
465                 470                 475                 480 


Asp Asp Asp Val Val Ser Arg Cys Thr Lys Glu Glu Ala Ile Glu His 
                485                 490                 495     


Asn Tyr Gly Gly His Asp Asp Asp Leu Ser Val Arg His Cys Thr Asn 
            500                 505                 510         


Ala Tyr Met Leu Val Tyr Ile Arg Glu Ser Lys Leu Ser Glu Val Leu 
        515                 520                 525             


Gln Ala Val Thr Asp His Asp Ile Pro Gln Gln Leu Val Glu Arg Leu 
    530                 535                 540                 


Gln Glu Glu Lys Arg Ile Glu Ala Gln Lys Arg Lys Glu Arg Gln Glu 
545                 550                 555                 560 


Ala His Leu Tyr Met Gln Val Gln Ile Val Ala Glu Asp Gln Phe Cys 
                565                 570                 575     


Gly His Gln Gly Asn Asp Met Tyr Asp Glu Glu Lys Val Lys Tyr Thr 
            580                 585                 590         


Val Phe Lys Val Leu Lys Asn Ser Ser Leu Ala Glu Phe Val Gln Ser 
        595                 600                 605             


Leu Ser Gln Thr Met Gly Phe Pro Gln Asp Gln Ile Arg Leu Trp Pro 
    610                 615                 620                 


Met Gln Ala Arg Ser Asn Gly Thr Lys Arg Pro Ala Met Leu Asp Asn 
625                 630                 635                 640 


Glu Ala Asp Gly Asn Lys Thr Met Ile Glu Leu Ser Asp Asn Glu Asn 
                645                 650                 655     


Pro Trp Thr Ile Phe Leu Glu Thr Val Asp Pro Glu Leu Ala Ala Ser 
            660                 665                 670         


Gly Ala Thr Leu Pro Lys Phe Asp Lys Asp His Asp Val Met Leu Phe 
        675                 680                 685             


Leu Lys Met Tyr Asp Pro Lys Thr Arg Ser Leu Asn Tyr Cys Gly His 
    690                 695                 700                 


Ile Tyr Thr Pro Ile Ser Cys Lys Ile Arg Asp Leu Leu Pro Val Met 
705                 710                 715                 720 


Cys Asp Arg Ala Gly Phe Ile Gln Asp Thr Ser Leu Ile Leu Tyr Glu 
                725                 730                 735     


Glu Val Lys Pro Asn Leu Thr Glu Arg Ile Gln Asp Tyr Asp Val Ser 
            740                 745                 750         


Leu Asp Lys Ala Leu Asp Glu Leu Met Asp Gly Asp Ile Ile Val Phe 
        755                 760                 765             


Gln Lys Asp Asp Pro Glu Asn Asp Asn Ser Glu Leu Pro Thr Ala Lys 
    770                 775                 780                 


Glu Tyr Phe Arg Asp Leu Tyr His Arg Val Asp Val Ile Phe Cys Asp 
785                 790                 795                 800 


Lys Thr Ile Pro Asn Asp Pro Gly Phe Val Val Thr Leu Ser Asn Arg 
                805                 810                 815     


Met Asn Tyr Phe Gln Val Ala Lys Thr Val Ala Gln Arg Leu Asn Thr 
            820                 825                 830         


Asp Pro Met Leu Leu Gln Phe Phe Lys Ser Gln Gly Tyr Arg Asp Gly 
        835                 840                 845             


Pro Gly Asn Pro Leu Arg His Asn Tyr Glu Gly Thr Leu Arg Asp Leu 
    850                 855                 860                 


Leu Gln Phe Phe Lys Pro Arg Gln Pro Lys Lys Leu Tyr Tyr Gln Gln 
865                 870                 875                 880 


Leu Lys Met Lys Ile Thr Asp Phe Glu Asn Arg Arg Ser Phe Lys Cys 
                885                 890                 895     


Ile Trp Leu Asn Ser Gln Phe Arg Glu Glu Glu Ile Thr Leu Tyr Pro 
            900                 905                 910         


Asp Lys His Gly Cys Val Arg Asp Leu Leu Glu Glu Cys Lys Lys Ala 
        915                 920                 925             


Val Glu Leu Gly Glu Lys Ala Ser Gly Lys Leu Arg Leu Leu Glu Ile 
    930                 935                 940                 


Val Ser Tyr Lys Ile Ile Gly Val His Gln Glu Asp Glu Leu Leu Glu 
945                 950                 955                 960 


Cys Leu Ser Pro Ala Thr Ser Arg Thr Phe Arg Ile Glu Glu Ile Pro 
                965                 970                 975     


Leu Asp Gln Val Asp Ile Asp Lys Glu Asn Glu Met Leu Val Thr Val 
            980                 985                 990         


Ala His Phe His Lys Glu Val Phe  Gly Thr Phe Gly Ile  Pro Phe Leu 
        995                 1000                 1005             


Leu Arg  Ile His Gln Gly Glu  His Phe Arg Glu Val  Met Lys Arg 
    1010                 1015                 1020             


Ile Gln  Ser Leu Leu Asp Ile  Gln Glu Lys Glu Phe  Glu Lys Phe 
    1025                 1030                 1035             


Lys Phe  Ala Ile Val Met Met  Gly Arg His Gln Tyr  Ile Asn Glu 
    1040                 1045                 1050             


Asp Glu  Tyr Glu Val Asn Leu  Lys Asp Phe Glu Pro  Gln Pro Gly 
    1055                 1060                 1065             


Asn Met  Ser His Pro Arg Pro  Trp Leu Gly Leu Asp  His Phe Asn 
    1070                 1075                 1080             


Lys Ala  Pro Lys Arg Ser Arg  Tyr Thr Tyr Leu Glu  Lys Ala Ile 
    1085                 1090                 1095             


Lys Ile  His Asn 
    1100         


<210>  32
<211>  926
<212>  PRT
<213>  Homo sapiens

<400>  32

Met Val Ser Ser Val Leu Pro Asn Pro Thr Ser Ala Glu Cys Trp Ala 
1               5                   10                  15      


Ala Leu Leu His Asp Pro Met Thr Leu Asp Met Asp Ala Val Leu Ser 
            20                  25                  30          


Asp Phe Val Arg Ser Thr Gly Ala Glu Pro Gly Leu Ala Arg Asp Leu 
        35                  40                  45              


Leu Glu Gly Lys Asn Trp Asp Leu Thr Ala Ala Leu Ser Asp Tyr Glu 
    50                  55                  60                  


Gln Leu Arg Gln Val His Thr Ala Asn Leu Pro His Val Phe Asn Glu 
65                  70                  75                  80  


Gly Arg Gly Pro Lys Gln Pro Glu Arg Glu Pro Gln Pro Gly His Lys 
                85                  90                  95      


Val Glu Arg Pro Cys Leu Gln Arg Gln Asp Asp Ile Ala Gln Glu Lys 
            100                 105                 110         


Arg Leu Ser Arg Gly Ile Ser His Ala Ser Ser Ala Ile Val Ser Leu 
        115                 120                 125             


Ala Arg Ser His Val Ala Ser Glu Cys Asn Asn Glu Gln Phe Pro Leu 
    130                 135                 140                 


Glu Met Pro Ile Tyr Thr Phe Gln Leu Pro Asp Leu Ser Val Tyr Ser 
145                 150                 155                 160 


Glu Asp Phe Arg Ser Phe Ile Glu Arg Asp Leu Ile Glu Gln Ala Thr 
                165                 170                 175     


Met Val Ala Leu Glu Gln Ala Gly Arg Leu Asn Trp Trp Ser Thr Val 
            180                 185                 190         


Cys Thr Ser Cys Lys Arg Leu Leu Pro Leu Ala Thr Thr Gly Asp Gly 
        195                 200                 205             


Asn Cys Leu Leu His Ala Ala Ser Leu Gly Met Trp Gly Phe His Asp 
    210                 215                 220                 


Arg Asp Leu Val Leu Arg Lys Ala Leu Tyr Thr Met Met Arg Thr Gly 
225                 230                 235                 240 


Ala Glu Arg Glu Ala Leu Lys Arg Arg Trp Arg Trp Gln Gln Thr Gln 
                245                 250                 255     


Gln Asn Lys Glu Glu Glu Trp Glu Arg Glu Trp Thr Glu Leu Leu Lys 
            260                 265                 270         


Leu Ala Ser Ser Glu Pro Arg Thr His Phe Ser Lys Asn Gly Gly Thr 
        275                 280                 285             


Gly Gly Gly Val Asp Asn Ser Glu Asp Pro Val Tyr Glu Ser Leu Glu 
    290                 295                 300                 


Glu Phe His Val Phe Val Leu Ala His Ile Leu Arg Arg Pro Ile Val 
305                 310                 315                 320 


Val Val Ala Asp Thr Met Leu Arg Asp Ser Gly Gly Glu Ala Phe Ala 
                325                 330                 335     


Pro Ile Pro Phe Gly Gly Ile Tyr Leu Pro Leu Glu Val Pro Pro Asn 
            340                 345                 350         


Arg Cys His Cys Ser Pro Leu Val Leu Ala Tyr Asp Gln Ala His Phe 
        355                 360                 365             


Ser Ala Leu Val Ser Met Glu Gln Arg Asp Gln Gln Arg Glu Gln Ala 
    370                 375                 380                 


Val Ile Pro Leu Thr Asp Ser Glu His Lys Leu Leu Pro Leu His Phe 
385                 390                 395                 400 


Ala Val Asp Pro Gly Lys Asp Trp Glu Trp Gly Lys Asp Asp Asn Asp 
                405                 410                 415     


Asn Ala Arg Leu Ala His Leu Ile Leu Ser Leu Glu Ala Lys Leu Asn 
            420                 425                 430         


Leu Leu His Ser Tyr Met Asn Val Thr Trp Ile Arg Ile Pro Ser Glu 
        435                 440                 445             


Thr Arg Ala Pro Leu Ala Gln Pro Glu Ser Pro Thr Ala Ser Ala Gly 
    450                 455                 460                 


Glu Asp Val Gln Ser Leu Ala Asp Ser Leu Asp Ser Asp Arg Asp Ser 
465                 470                 475                 480 


Val Cys Ser Asn Ser Asn Ser Asn Asn Gly Lys Asn Gly Lys Asp Lys 
                485                 490                 495     


Glu Lys Glu Lys Gln Arg Lys Glu Lys Asp Lys Thr Arg Ala Asp Ser 
            500                 505                 510         


Val Ala Asn Lys Leu Gly Ser Phe Ser Lys Thr Leu Gly Ile Lys Leu 
        515                 520                 525             


Lys Lys Asn Met Gly Gly Leu Gly Gly Leu Val His Gly Lys Met Gly 
    530                 535                 540                 


Arg Ala Asn Ser Ala Asn Gly Lys Asn Gly Asp Ser Ala Glu Arg Gly 
545                 550                 555                 560 


Lys Glu Lys Lys Ala Lys Ser Arg Lys Gly Ser Lys Glu Glu Ser Gly 
                565                 570                 575     


Ala Ser Ala Ser Thr Ser Pro Ser Glu Lys Thr Thr Pro Ser Pro Thr 
            580                 585                 590         


Asp Lys Ala Ala Gly Ala Ser Pro Ala Glu Lys Gly Gly Gly Pro Arg 
        595                 600                 605             


Gly Asp Ala Trp Lys Tyr Ser Thr Asp Val Lys Leu Ser Leu Asn Ile 
    610                 615                 620                 


Leu Arg Ala Ala Met Gln Gly Glu Arg Lys Phe Ile Phe Ala Gly Leu 
625                 630                 635                 640 


Leu Leu Thr Ser His Arg His Gln Phe His Glu Glu Met Ile Gly Tyr 
                645                 650                 655     


Tyr Leu Thr Ser Ala Gln Glu Arg Phe Ser Ala Glu Gln Glu Gln Arg 
            660                 665                 670         


Arg Arg Asp Ala Ala Thr Ala Ala Ala Ala Ala Ala Ala Ala Ala Ala 
        675                 680                 685             


Ala Thr Ala Lys Arg Pro Pro Arg Arg Pro Glu Thr Glu Gly Val Pro 
    690                 695                 700                 


Val Pro Glu Arg Ala Ser Pro Gly Pro Pro Thr Gln Leu Val Leu Lys 
705                 710                 715                 720 


Leu Lys Glu Arg Pro Ser Pro Gly Pro Ala Ala Gly Arg Ala Ala Arg 
                725                 730                 735     


Ala Ala Ala Gly Gly Thr Ala Ser Pro Gly Gly Gly Ala Arg Arg Ala 
            740                 745                 750         


Ser Ala Ser Gly Pro Val Pro Gly Arg Ser Pro Pro Ala Pro Ala Arg 
        755                 760                 765             


Gln Ser Val Ile His Val Gln Ala Ser Gly Ala Arg Asp Glu Ala Cys 
    770                 775                 780                 


Ala Pro Ala Val Gly Ala Leu Arg Pro Cys Ala Thr Tyr Pro Gln Gln 
785                 790                 795                 800 


Asn Arg Ser Leu Ser Ser Gln Ser Tyr Ser Pro Ala Arg Ala Ala Ala 
                805                 810                 815     


Leu Arg Thr Val Asn Thr Val Glu Ser Leu Ala Arg Ala Val Pro Gly 
            820                 825                 830         


Ala Leu Pro Gly Ala Ala Gly Thr Ala Gly Ala Ala Glu His Lys Ser 
        835                 840                 845             


Gln Thr Tyr Thr Asn Gly Phe Gly Ala Leu Arg Asp Gly Leu Glu Phe 
    850                 855                 860                 


Ala Asp Ala Asp Ala Pro Thr Ala Arg Ser Asn Gly Glu Cys Gly Arg 
865                 870                 875                 880 


Gly Gly Pro Gly Pro Val Gln Arg Arg Cys Gln Arg Glu Asn Cys Ala 
                885                 890                 895     


Phe Tyr Gly Arg Ala Glu Thr Glu His Tyr Cys Ser Tyr Cys Tyr Arg 
            900                 905                 910         


Glu Glu Leu Arg Arg Arg Arg Glu Ala Arg Gly Ala Arg Pro 
        915                 920                 925     


<210>  33
<211>  494
<212>  PRT
<213>  Homo sapiens

<400>  33

Met Pro Leu Tyr Ser Val Thr Val Lys Trp Gly Lys Glu Lys Phe Glu 
1               5                   10                  15      


Gly Val Glu Leu Asn Thr Asp Glu Pro Pro Met Val Phe Lys Ala Gln 
            20                  25                  30          


Leu Phe Ala Leu Thr Gly Val Gln Pro Ala Arg Gln Lys Val Met Val 
        35                  40                  45              


Lys Gly Gly Thr Leu Lys Asp Asp Asp Trp Gly Asn Ile Lys Ile Lys 
    50                  55                  60                  


Asn Gly Met Thr Leu Leu Met Met Gly Ser Ala Asp Ala Leu Pro Glu 
65                  70                  75                  80  


Glu Pro Ser Ala Lys Thr Val Phe Val Glu Asp Met Thr Glu Glu Gln 
                85                  90                  95      


Leu Ala Ser Ala Met Glu Leu Pro Cys Gly Leu Thr Asn Leu Gly Asn 
            100                 105                 110         


Thr Cys Tyr Met Asn Ala Thr Val Gln Cys Ile Arg Ser Val Pro Glu 
        115                 120                 125             


Leu Lys Asp Ala Leu Lys Arg Tyr Ala Gly Ala Leu Arg Ala Ser Gly 
    130                 135                 140                 


Glu Met Ala Ser Ala Gln Tyr Ile Thr Ala Ala Leu Arg Asp Leu Phe 
145                 150                 155                 160 


Asp Ser Met Asp Lys Thr Ser Ser Ser Ile Pro Pro Ile Ile Leu Leu 
                165                 170                 175     


Gln Phe Leu His Met Ala Phe Pro Gln Phe Ala Glu Lys Gly Glu Gln 
            180                 185                 190         


Gly Gln Tyr Leu Gln Gln Asp Ala Asn Glu Cys Trp Ile Gln Met Met 
        195                 200                 205             


Arg Val Leu Gln Gln Lys Leu Glu Ala Ile Glu Asp Asp Ser Val Lys 
    210                 215                 220                 


Glu Thr Asp Ser Ser Ser Ala Ser Ala Ala Thr Pro Ser Lys Lys Lys 
225                 230                 235                 240 


Ser Leu Ile Asp Gln Phe Phe Gly Val Glu Phe Glu Thr Thr Met Lys 
                245                 250                 255     


Cys Thr Glu Ser Glu Glu Glu Glu Val Thr Lys Gly Lys Glu Asn Gln 
            260                 265                 270         


Leu Gln Leu Ser Cys Phe Ile Asn Gln Glu Val Lys Tyr Leu Phe Thr 
        275                 280                 285             


Gly Leu Lys Leu Arg Leu Gln Glu Glu Ile Thr Lys Gln Ser Pro Thr 
    290                 295                 300                 


Leu Gln Arg Asn Ala Leu Tyr Ile Lys Ser Ser Lys Ile Ser Arg Leu 
305                 310                 315                 320 


Pro Ala Tyr Leu Thr Ile Gln Met Val Arg Phe Phe Tyr Lys Glu Lys 
                325                 330                 335     


Glu Ser Val Asn Ala Lys Val Leu Lys Asp Val Lys Phe Pro Leu Met 
            340                 345                 350         


Leu Asp Met Tyr Glu Leu Cys Thr Pro Glu Leu Gln Glu Lys Met Val 
        355                 360                 365             


Ser Phe Arg Ser Lys Phe Lys Asp Leu Glu Asp Lys Lys Val Asn Gln 
    370                 375                 380                 


Gln Pro Asn Thr Ser Asp Lys Lys Ser Ser Pro Gln Lys Glu Val Lys 
385                 390                 395                 400 


Tyr Glu Pro Phe Ser Phe Ala Asp Asp Ile Gly Ser Asn Asn Cys Gly 
                405                 410                 415     


Tyr Tyr Asp Leu Gln Ala Val Leu Thr His Gln Gly Arg Ser Ser Ser 
            420                 425                 430         


Ser Gly His Tyr Val Ser Trp Val Lys Arg Lys Gln Asp Glu Trp Ile 
        435                 440                 445             


Lys Phe Asp Asp Asp Lys Val Ser Ile Val Thr Pro Glu Asp Ile Leu 
    450                 455                 460                 


Arg Leu Ser Gly Gly Gly Asp Trp His Ile Ala Tyr Val Leu Leu Tyr 
465                 470                 475                 480 


Gly Pro Arg Arg Val Glu Ile Met Glu Glu Glu Ser Glu Gln 
                485                 490                 


<210>  34
<211>  858
<212>  PRT
<213>  Homo sapiens

<400>  34

Met Ala Glu Leu Ser Glu Glu Ala Leu Leu Ser Val Leu Pro Thr Ile 
1               5                   10                  15      


Arg Val Pro Lys Ala Gly Asp Arg Val His Lys Asp Glu Cys Ala Phe 
            20                  25                  30          


Ser Phe Asp Thr Pro Glu Ser Glu Gly Gly Leu Tyr Ile Cys Met Asn 
        35                  40                  45              


Thr Phe Leu Gly Phe Gly Lys Gln Tyr Val Glu Arg His Phe Asn Lys 
    50                  55                  60                  


Thr Gly Gln Arg Val Tyr Leu His Leu Arg Arg Thr Arg Arg Pro Lys 
65                  70                  75                  80  


Glu Glu Asp Pro Ala Thr Gly Thr Gly Asp Pro Pro Arg Lys Lys Pro 
                85                  90                  95      


Thr Arg Leu Ala Ile Gly Val Glu Gly Gly Phe Asp Leu Ser Glu Glu 
            100                 105                 110         


Lys Phe Glu Leu Asp Glu Asp Val Lys Ile Val Ile Leu Pro Asp Tyr 
        115                 120                 125             


Leu Glu Ile Ala Arg Asp Gly Leu Gly Gly Leu Pro Asp Ile Val Arg 
    130                 135                 140                 


Asp Arg Val Thr Ser Ala Val Glu Ala Leu Leu Ser Ala Asp Ser Ala 
145                 150                 155                 160 


Ser Arg Lys Gln Glu Val Gln Ala Trp Asp Gly Glu Val Arg Gln Val 
                165                 170                 175     


Ser Lys His Ala Phe Ser Leu Lys Gln Leu Asp Asn Pro Ala Arg Ile 
            180                 185                 190         


Pro Pro Cys Gly Trp Lys Cys Ser Lys Cys Asp Met Arg Glu Asn Leu 
        195                 200                 205             


Trp Leu Asn Leu Thr Asp Gly Ser Ile Leu Cys Gly Arg Arg Tyr Phe 
    210                 215                 220                 


Asp Gly Ser Gly Gly Asn Asn His Ala Val Glu His Tyr Arg Glu Thr 
225                 230                 235                 240 


Gly Tyr Pro Leu Ala Val Lys Leu Gly Thr Ile Thr Pro Asp Gly Ala 
                245                 250                 255     


Asp Val Tyr Ser Tyr Asp Glu Asp Asp Met Val Leu Asp Pro Ser Leu 
            260                 265                 270         


Ala Glu His Leu Ser His Phe Gly Ile Asp Met Leu Lys Met Gln Lys 
        275                 280                 285             


Thr Asp Lys Thr Met Thr Glu Leu Glu Ile Asp Met Asn Gln Arg Ile 
    290                 295                 300                 


Gly Glu Trp Glu Leu Ile Gln Glu Ser Gly Val Pro Leu Lys Pro Leu 
305                 310                 315                 320 


Phe Gly Pro Gly Tyr Thr Gly Ile Arg Asn Leu Gly Asn Ser Cys Tyr 
                325                 330                 335     


Leu Asn Ser Val Val Gln Val Leu Phe Ser Ile Pro Asp Phe Gln Arg 
            340                 345                 350         


Lys Tyr Val Asp Lys Leu Glu Lys Ile Phe Gln Asn Ala Pro Thr Asp 
        355                 360                 365             


Pro Thr Gln Asp Phe Ser Thr Gln Val Ala Lys Leu Gly His Gly Leu 
    370                 375                 380                 


Leu Ser Gly Glu Tyr Ser Lys Pro Val Pro Glu Ser Gly Asp Gly Glu 
385                 390                 395                 400 


Arg Val Pro Glu Gln Lys Glu Val Gln Asp Gly Ile Ala Pro Arg Met 
                405                 410                 415     


Phe Lys Ala Leu Ile Gly Lys Gly His Pro Glu Phe Ser Thr Asn Arg 
            420                 425                 430         


Gln Gln Asp Ala Gln Glu Phe Phe Leu His Leu Ile Asn Met Val Glu 
        435                 440                 445             


Arg Asn Cys Arg Ser Ser Glu Asn Pro Asn Glu Val Phe Arg Phe Leu 
    450                 455                 460                 


Val Glu Glu Lys Ile Lys Cys Leu Ala Thr Glu Lys Val Lys Tyr Thr 
465                 470                 475                 480 


Gln Arg Val Asp Tyr Ile Met Gln Leu Pro Val Pro Met Asp Ala Ala 
                485                 490                 495     


Leu Asn Lys Glu Glu Leu Leu Glu Tyr Glu Glu Lys Lys Arg Gln Ala 
            500                 505                 510         


Glu Glu Glu Lys Met Ala Leu Pro Glu Leu Val Arg Ala Gln Val Pro 
        515                 520                 525             


Phe Ser Ser Cys Leu Glu Ala Tyr Gly Ala Pro Glu Gln Val Asp Asp 
    530                 535                 540                 


Phe Trp Ser Thr Ala Leu Gln Ala Lys Ser Val Ala Val Lys Thr Thr 
545                 550                 555                 560 


Arg Phe Ala Ser Phe Pro Asp Tyr Leu Val Ile Gln Ile Lys Lys Phe 
                565                 570                 575     


Thr Phe Gly Leu Asp Trp Val Pro Lys Lys Leu Asp Val Ser Ile Glu 
            580                 585                 590         


Met Pro Glu Glu Leu Asp Ile Ser Gln Leu Arg Gly Thr Gly Leu Gln 
        595                 600                 605             


Pro Gly Glu Glu Glu Leu Pro Asp Ile Ala Pro Pro Leu Val Thr Pro 
    610                 615                 620                 


Asp Glu Pro Lys Gly Ser Leu Gly Phe Tyr Gly Asn Glu Asp Glu Asp 
625                 630                 635                 640 


Ser Phe Cys Ser Pro His Phe Ser Ser Pro Thr Ser Pro Met Leu Asp 
                645                 650                 655     


Glu Ser Val Ile Ile Gln Leu Val Glu Met Gly Phe Pro Met Asp Ala 
            660                 665                 670         


Cys Arg Lys Ala Val Tyr Tyr Thr Gly Asn Ser Gly Ala Glu Ala Ala 
        675                 680                 685             


Met Asn Trp Val Met Ser His Met Asp Asp Pro Asp Phe Ala Asn Pro 
    690                 695                 700                 


Leu Ile Leu Pro Gly Ser Ser Gly Pro Gly Ser Thr Ser Ala Ala Ala 
705                 710                 715                 720 


Asp Pro Pro Pro Glu Asp Cys Val Thr Thr Ile Val Ser Met Gly Phe 
                725                 730                 735     


Ser Arg Asp Gln Ala Leu Lys Ala Leu Arg Ala Thr Asn Asn Ser Leu 
            740                 745                 750         


Glu Arg Ala Val Asp Trp Ile Phe Ser His Ile Asp Asp Leu Asp Ala 
        755                 760                 765             


Glu Ala Ala Met Asp Ile Ser Glu Gly Arg Ser Ala Ala Asp Ser Ile 
    770                 775                 780                 


Ser Glu Ser Val Pro Val Gly Pro Lys Val Arg Asp Gly Pro Gly Lys 
785                 790                 795                 800 


Tyr Gln Leu Phe Ala Phe Ile Ser His Met Gly Thr Ser Thr Met Cys 
                805                 810                 815     


Gly His Tyr Val Cys His Ile Lys Lys Glu Gly Arg Trp Val Ile Tyr 
            820                 825                 830         


Asn Asp Gln Lys Val Cys Ala Ser Glu Lys Pro Pro Lys Asp Leu Gly 
        835                 840                 845             


Tyr Ile Tyr Phe Tyr Gln Arg Val Ala Ser 
    850                 855             


