﻿               SEQUENCE LISTING

<110> ETH Zürich

<120> Chimera Proteins

<130> F05936

<160> 16

<170> BiSSAP 1.3.6

<210> 1
<211> 234
<212> PRT
<213> Homo sapiens


<400> 1
Met Gly Ser Ser His His His His His His Ser Ser Gly Leu Val Pro 
1               5                   10                  15      
Arg Gly Ser His Met Arg Ile Ile Leu Leu Gly Ala Pro Gly Ala Gly 
            20                  25                  30          
Lys Gly Thr Gln Ala Gln Phe Ile Met Glu Lys Tyr Gly Ile Pro Gln 
        35                  40                  45              
Ile Ser Thr Gly Asp Met Leu Arg Ala Ala Val Lys Ser Gly Ser Glu 
    50                  55                  60                  
Leu Gly Lys Gln Ala Lys Asp Ile Met Asp Ala Gly Lys Leu Val Thr 
65                  70                  75                  80  
Asp Glu Leu Val Ile Ala Leu Val Lys Glu Arg Ile Ala Gln Glu Asp 
                85                  90                  95      
Cys Arg Asn Gly Phe Leu Leu Asp Gly Phe Pro Arg Thr Ile Pro Gln 
            100                 105                 110         
Ala Asp Ala Met Lys Glu Ala Gly Ile Asn Val Asp Tyr Val Leu Glu 
        115                 120                 125             
Phe Asp Val Pro Asp Glu Leu Ile Val Asp Arg Ile Val Gly Arg Arg 
    130                 135                 140                 
Val His Ala Pro Ser Gly Arg Val Tyr His Val Lys Phe Asn Pro Pro 
145                 150                 155                 160 
Lys Val Glu Gly Lys Asp Asp Val Thr Gly Glu Glu Leu Thr Thr Arg 
                165                 170                 175     
Lys Asp Asp Gln Glu Glu Thr Val Arg Lys Arg Leu Val Glu Tyr His 
            180                 185                 190         
Gln Met Thr Ala Pro Leu Ile Gly Tyr Tyr Ser Lys Glu Ala Glu Ala 
        195                 200                 205             
Gly Asn Thr Lys Tyr Ala Lys Val Asp Gly Thr Lys Pro Val Ala Glu 
    210                 215                 220                 
Val Arg Ala Asp Leu Glu Lys Ile Leu Gly 
225                 230                 

<210> 2
<211> 385
<212> PRT
<213> Homo sapiens


<400> 2
Met Gly Ser Ser His His His His His His Ser Ser Gly Leu Val Pro 
1               5                   10                  15      
Arg Gly Ser His Met Met Arg Ile Ile Leu Leu Gly Ala Pro Gly Ala 
            20                  25                  30          
Gly Lys Gly Thr Gln Ala Gln Phe Ile Met Glu Lys Tyr Gly Ile Pro 
        35                  40                  45              
Gln Ile Ser Thr Gly Asp Met Leu Arg Ala Ala Val Lys Ser Gly Ser 
    50                  55                  60                  
Glu Leu Gly Lys Gln Ala Lys Asp Ile Met Asp Ala Gly Lys Leu Val 
65                  70                  75                  80  
Thr Asp Glu Leu Val Ile Ala Leu Val Lys Glu Arg Ile Ala Gln Glu 
                85                  90                  95      
Asp Cys Arg Asn Gly Phe Leu Leu Asp Gly Phe Pro Arg Thr Ile Pro 
            100                 105                 110         
Gln Ala Asp Ala Met Lys Glu Ala Gly Ile Asn Val Asp Tyr Val Leu 
        115                 120                 125             
Glu Phe Asp Val Pro Asp Glu Leu Ile Val Asp Arg Ile Val Gly Arg 
    130                 135                 140                 
Arg Val His Ala Pro Ser Gly Arg Val Tyr His Val Lys Phe Asn Pro 
145                 150                 155                 160 
Pro Lys Val Glu Gly Lys Asp Asp Val Thr Gly Glu Glu Leu Thr Thr 
                165                 170                 175     
Arg Lys Asp Asp Gln Glu Glu Thr Val Arg Lys Arg Leu Val Glu Tyr 
            180                 185                 190         
His Gln Met Thr Ala Pro Leu Ile Gly Tyr Tyr Ser Lys Glu Ala Glu 
        195                 200                 205             
Ala Gly Asn Thr Lys Tyr Ala Lys Val Asp Gly Thr Lys Pro Val Ala 
    210                 215                 220                 
Glu Val Arg Ala Asp Leu Glu Lys Ile Leu Gly Val His Pro Gly Val 
225                 230                 235                 240 
Gly Val His Pro Gly Val Gly Val His Pro Gly Val Gly Val His Pro 
                245                 250                 255     
Gly Val Gly Val His Pro Gly Val Gly Val His Pro Gly Val Gly Val 
            260                 265                 270         
His Pro Gly Val Gly Val His Pro Gly Val Gly Val His Pro Gly Val 
        275                 280                 285             
Gly Val His Pro Gly Val Gly Val His Pro Gly Val Gly Val His Pro 
    290                 295                 300                 
Gly Val Gly Val His Pro Gly Val Gly Val His Pro Gly Val Gly Val 
305                 310                 315                 320 
His Pro Gly Val Gly Val His Pro Gly Val Gly Val His Pro Gly Val 
                325                 330                 335     
Gly Val His Pro Gly Val Gly Val His Pro Gly Val Gly Val His Pro 
            340                 345                 350         
Gly Val Gly Val His Pro Gly Val Gly Val His Pro Gly Val Gly Val 
        355                 360                 365             
His Pro Gly Val Gly Val His Pro Gly Val Gly Val His Pro Gly Val 
    370                 375                 380                 
Gly 
385 

<210> 3
<211> 362
<212> PRT
<213> Homo sapiens


<400> 3
Met Gly Ser Ser His His His His His His Ser Ser Gly Leu Val Pro 
1               5                   10                  15      
Arg Gly Ser His Met Gly Ser Ile Asn Asn Asn Phe Asn Thr Asn Asn 
            20                  25                  30          
Asn Ser Asn Thr Asp Leu Asp Arg Asp Trp Lys Thr Ala Leu Asn Ile 
        35                  40                  45              
Pro Lys Lys Asp Thr Arg Pro Gln Thr Asp Asp Val Leu Asn Thr Lys 
    50                  55                  60                  
Gly Asn Thr Met Arg Ile Ile Leu Leu Gly Ala Pro Gly Ala Gly Lys 
65                  70                  75                  80  
Gly Thr Gln Ala Gln Phe Ile Met Glu Lys Tyr Gly Ile Pro Gln Ile 
                85                  90                  95      
Ser Thr Gly Asp Met Leu Arg Ala Ala Val Lys Ser Gly Ser Glu Leu 
            100                 105                 110         
Gly Lys Gln Ala Lys Asp Ile Met Asp Ala Gly Lys Leu Val Thr Asp 
        115                 120                 125             
Glu Leu Val Ile Ala Leu Val Lys Glu Arg Ile Ala Gln Glu Asp Cys 
    130                 135                 140                 
Arg Asn Gly Phe Leu Leu Asp Gly Phe Pro Arg Thr Ile Pro Gln Ala 
145                 150                 155                 160 
Asp Ala Met Lys Glu Ala Gly Ile Asn Val Asp Tyr Val Leu Glu Phe 
                165                 170                 175     
Asp Val Pro Asp Glu Leu Ile Val Asp Arg Ile Val Gly Arg Arg Val 
            180                 185                 190         
His Ala Pro Ser Gly Arg Val Tyr His Val Lys Phe Asn Pro Pro Lys 
        195                 200                 205             
Val Glu Gly Lys Asp Asp Val Thr Gly Glu Glu Leu Thr Thr Arg Lys 
    210                 215                 220                 
Asp Asp Gln Glu Glu Thr Val Arg Lys Arg Leu Val Glu Tyr His Gln 
225                 230                 235                 240 
Met Thr Ala Pro Leu Ile Gly Tyr Tyr Ser Lys Glu Ala Glu Ala Gly 
                245                 250                 255     
Asn Thr Lys Tyr Ala Lys Val Asp Gly Thr Lys Pro Val Ala Glu Val 
            260                 265                 270         
Arg Ala Asp Leu Glu Lys Ile Leu Gly Val Pro Val Pro Phe Pro Ile 
        275                 280                 285             
Glu Gln Gln Ser Tyr His Gln Gln Ala Ile Pro Gln Gln Gln Leu Pro 
    290                 295                 300                 
Ser Gln Gln Gln Phe Ala Ile Pro Pro Gln Gln His His Pro Gln Phe 
305                 310                 315                 320 
Met Val Pro Pro Ser His Gln Gln Gln Gln Ala Tyr Pro Pro Pro Gln 
                325                 330                 335     
Met Pro Ser Gln Gln Gly Tyr Pro Pro Gln Gln Glu His Phe Met Ala 
            340                 345                 350         
Met Pro Pro Gly Gln Ser Gln Pro Gln Tyr 
        355                 360         

<210> 4
<211> 456
<212> PRT
<213> Homo sapiens


<400> 4
Met Gly Ser Ser His His His His His His Ser Ser Gly Leu Val Pro 
1               5                   10                  15      
Arg Gly Ser His Met Ala Asp Leu Pro Gln Lys Val Ser Asn Leu Ser 
            20                  25                  30          
Ile Asn Asn Lys Glu Asn Gly Gly Gly Gly Gly Lys Ser Ser Tyr Val 
        35                  40                  45              
Pro Pro His Leu Arg Ser Arg Gly Lys Pro Ser Phe Glu Arg Arg Ser 
    50                  55                  60                  
Pro Lys Gln Lys Asp Lys Val Thr Gly Gly Asp Phe Phe Arg Arg Ala 
65                  70                  75                  80  
Gly Arg Gln Thr Gly Asn Asn Gly Gly Phe Phe Gly Phe Ser Lys Glu 
                85                  90                  95      
Arg Asn Gly Gly Thr Ser Ala Asn Tyr Asn Arg Arg Gly Ser Ser Asn 
            100                 105                 110         
Tyr Lys Ser Ser Gly Asn Arg Trp Val Asn Gly Lys His Ile Pro Gly 
        115                 120                 125             
Pro Lys Asn Ala Lys Leu Gln Lys Ala Glu Leu Phe Gly Val His Asp 
    130                 135                 140                 
Asp Pro Asp Tyr His Ser Ser Gly Ile Lys Phe Asp Asn Tyr Asp Asn 
145                 150                 155                 160 
Ile Pro Val Asp Ala Ser Gly Lys Asp Val Pro Glu Pro Ile Leu Met 
                165                 170                 175     
Arg Ile Ile Leu Leu Gly Ala Pro Gly Ala Gly Lys Gly Thr Gln Ala 
            180                 185                 190         
Gln Phe Ile Met Glu Lys Tyr Gly Ile Pro Gln Ile Ser Thr Gly Asp 
        195                 200                 205             
Met Leu Arg Ala Ala Val Lys Ser Gly Ser Glu Leu Gly Lys Gln Ala 
    210                 215                 220                 
Lys Asp Ile Met Asp Ala Gly Lys Leu Val Thr Asp Glu Leu Val Ile 
225                 230                 235                 240 
Ala Leu Val Lys Glu Arg Ile Ala Gln Glu Asp Cys Arg Asn Gly Phe 
                245                 250                 255     
Leu Leu Asp Gly Phe Pro Arg Thr Ile Pro Gln Ala Asp Ala Met Lys 
            260                 265                 270         
Glu Ala Gly Ile Asn Val Asp Tyr Val Leu Glu Phe Asp Val Pro Asp 
        275                 280                 285             
Glu Leu Ile Val Asp Arg Ile Val Gly Arg Arg Val His Ala Pro Ser 
    290                 295                 300                 
Gly Arg Val Tyr His Val Lys Phe Asn Pro Pro Lys Val Glu Gly Lys 
305                 310                 315                 320 
Asp Asp Val Thr Gly Glu Glu Leu Thr Thr Arg Lys Asp Asp Gln Glu 
                325                 330                 335     
Glu Thr Val Arg Lys Arg Leu Val Glu Tyr His Gln Met Thr Ala Pro 
            340                 345                 350         
Leu Ile Gly Tyr Tyr Ser Lys Glu Ala Glu Ala Gly Asn Thr Lys Tyr 
        355                 360                 365             
Ala Lys Val Asp Gly Thr Lys Pro Val Ala Glu Val Arg Ala Asp Leu 
    370                 375                 380                 
Glu Lys Ile Leu Gly Gly Gly Arg Thr Arg Gly Gly Gly Gly Phe Phe 
385                 390                 395                 400 
Asn Ser Arg Asn Asn Gly Ser Arg Asp Tyr Arg Lys His Gly Gly Asn 
                405                 410                 415     
Gly Ser Phe Gly Ser Thr Arg Pro Arg Asn Thr Gly Thr Ser Asn Trp 
            420                 425                 430         
Gly Ser Ile Gly Gly Gly Phe Arg Asn Asp Asn Glu Lys Asn Gly Tyr 
        435                 440                 445             
Gly Asn Ser Asn Ala Ser Trp Trp 
    450                 455     

<210> 5
<211> 387
<212> PRT
<213> Aequorea victoria


<400> 5
Met Gly Ser Ser His His His His His His Ser Ser Gly Leu Val Pro 
1               5                   10                  15      
Arg Gly Ser His Met Met Gly Ser Ile Asn Asn Asn Phe Asn Thr Asn 
            20                  25                  30          
Asn Asn Ser Asn Thr Asp Leu Asp Arg Asp Trp Lys Thr Ala Leu Asn 
        35                  40                  45              
Ile Pro Lys Lys Asp Thr Arg Pro Gln Thr Asp Asp Val Leu Asn Thr 
    50                  55                  60                  
Lys Gly Asn Thr Val Ser Lys Gly Glu Glu Leu Phe Thr Gly Val Val 
65                  70                  75                  80  
Pro Ile Leu Val Glu Leu Asp Gly Asp Val Asn Gly His Lys Phe Ser 
                85                  90                  95      
Val Ser Gly Glu Gly Glu Gly Asp Ala Thr Tyr Gly Lys Leu Thr Leu 
            100                 105                 110         
Lys Phe Ile Cys Thr Thr Gly Lys Leu Pro Val Pro Trp Pro Thr Leu 
        115                 120                 125             
Val Thr Thr Leu Thr Tyr Gly Val Gln Cys Phe Ser Arg Tyr Pro Asp 
    130                 135                 140                 
His Met Lys Gln His Asp Phe Phe Lys Ser Ala Met Pro Glu Gly Tyr 
145                 150                 155                 160 
Val Gln Glu Arg Thr Ile Phe Phe Lys Asp Asp Gly Asn Tyr Lys Thr 
                165                 170                 175     
Arg Ala Glu Val Lys Phe Glu Gly Asp Thr Leu Val Asn Arg Ile Glu 
            180                 185                 190         
Leu Lys Gly Ile Asp Phe Lys Glu Asp Gly Asn Ile Leu Gly His Lys 
        195                 200                 205             
Leu Glu Tyr Asn Tyr Asn Ser His Asn Val Tyr Ile Met Ala Asp Lys 
    210                 215                 220                 
Gln Lys Asn Gly Ile Lys Val Asn Phe Lys Ile Arg His Asn Ile Glu 
225                 230                 235                 240 
Asp Gly Ser Val Gln Leu Ala Asp His Tyr Gln Gln Asn Thr Pro Ile 
                245                 250                 255     
Gly Asp Gly Pro Val Leu Leu Pro Asp Asn His Tyr Leu Ser Thr Gln 
            260                 265                 270         
Ser Ala Leu Ser Lys Asp Pro Asn Glu Lys Arg Asp His Met Val Leu 
        275                 280                 285             
Leu Glu Phe Val Thr Ala Ala Gly Ile Thr Leu Gly Met Asp Glu Leu 
    290                 295                 300                 
Tyr Lys Val Pro Val Pro Phe Pro Ile Glu Gln Gln Ser Tyr His Gln 
305                 310                 315                 320 
Gln Ala Ile Pro Gln Gln Gln Leu Pro Ser Gln Gln Gln Phe Ala Ile 
                325                 330                 335     
Pro Pro Gln Gln His His Pro Gln Phe Met Val Pro Pro Ser His Gln 
            340                 345                 350         
Gln Gln Gln Ala Tyr Pro Pro Pro Gln Met Pro Ser Gln Gln Gly Tyr 
        355                 360                 365             
Pro Pro Gln Gln Glu His Phe Met Ala Met Pro Pro Gly Gln Ser Gln 
    370                 375                 380                 
Pro Gln Tyr 
385         

<210> 6
<211> 481
<212> PRT
<213> Aequorea victoria


<400> 6
Met Gly Ser Ser His His His His His His Ser Ser Gly Leu Val Pro 
1               5                   10                  15      
Arg Gly Ser His Met Met Ala Asp Leu Pro Gln Lys Val Ser Asn Leu 
            20                  25                  30          
Ser Ile Asn Asn Lys Glu Asn Gly Gly Gly Gly Gly Lys Ser Ser Tyr 
        35                  40                  45              
Val Pro Pro His Leu Arg Ser Arg Gly Lys Pro Ser Phe Glu Arg Arg 
    50                  55                  60                  
Ser Pro Lys Gln Lys Asp Lys Val Thr Gly Gly Asp Phe Phe Arg Arg 
65                  70                  75                  80  
Ala Gly Arg Gln Thr Gly Asn Asn Gly Gly Phe Phe Gly Phe Ser Lys 
                85                  90                  95      
Glu Arg Asn Gly Gly Thr Ser Ala Asn Tyr Asn Arg Arg Gly Ser Ser 
            100                 105                 110         
Asn Tyr Lys Ser Ser Gly Asn Arg Trp Val Asn Gly Lys His Ile Pro 
        115                 120                 125             
Gly Pro Lys Asn Ala Lys Leu Gln Lys Ala Glu Leu Phe Gly Val His 
    130                 135                 140                 
Asp Asp Pro Asp Tyr His Ser Ser Gly Ile Lys Phe Asp Asn Tyr Asp 
145                 150                 155                 160 
Asn Ile Pro Val Asp Ala Ser Gly Lys Asp Val Pro Glu Pro Ile Leu 
                165                 170                 175     
Val Ser Lys Gly Glu Glu Leu Phe Thr Gly Val Val Pro Ile Leu Val 
            180                 185                 190         
Glu Leu Asp Gly Asp Val Asn Gly His Lys Phe Ser Val Ser Gly Glu 
        195                 200                 205             
Gly Glu Gly Asp Ala Thr Tyr Gly Lys Leu Thr Leu Lys Phe Ile Cys 
    210                 215                 220                 
Thr Thr Gly Lys Leu Pro Val Pro Trp Pro Thr Leu Val Thr Thr Leu 
225                 230                 235                 240 
Thr Tyr Gly Val Gln Cys Phe Ser Arg Tyr Pro Asp His Met Lys Gln 
                245                 250                 255     
His Asp Phe Phe Lys Ser Ala Met Pro Glu Gly Tyr Val Gln Glu Arg 
            260                 265                 270         
Thr Ile Phe Phe Lys Asp Asp Gly Asn Tyr Lys Thr Arg Ala Glu Val 
        275                 280                 285             
Lys Phe Glu Gly Asp Thr Leu Val Asn Arg Ile Glu Leu Lys Gly Ile 
    290                 295                 300                 
Asp Phe Lys Glu Asp Gly Asn Ile Leu Gly His Lys Leu Glu Tyr Asn 
305                 310                 315                 320 
Tyr Asn Ser His Asn Val Tyr Ile Met Ala Asp Lys Gln Lys Asn Gly 
                325                 330                 335     
Ile Lys Val Asn Phe Lys Ile Arg His Asn Ile Glu Asp Gly Ser Val 
            340                 345                 350         
Gln Leu Ala Asp His Tyr Gln Gln Asn Thr Pro Ile Gly Asp Gly Pro 
        355                 360                 365             
Val Leu Leu Pro Asp Asn His Tyr Leu Ser Thr Gln Ser Ala Leu Ser 
    370                 375                 380                 
Lys Asp Pro Asn Glu Lys Arg Asp His Met Val Leu Leu Glu Phe Val 
385                 390                 395                 400 
Thr Ala Ala Gly Ile Thr Leu Gly Met Asp Glu Leu Tyr Lys Gly Gly 
                405                 410                 415     
Arg Thr Arg Gly Gly Gly Gly Phe Phe Asn Ser Arg Asn Asn Gly Ser 
            420                 425                 430         
Arg Asp Tyr Arg Lys His Gly Gly Asn Gly Ser Phe Gly Ser Thr Arg 
        435                 440                 445             
Pro Arg Asn Thr Gly Thr Ser Asn Trp Gly Ser Ile Gly Gly Gly Phe 
    450                 455                 460                 
Arg Asn Asp Asn Glu Lys Asn Gly Tyr Gly Asn Ser Asn Ala Ser Trp 
465                 470                 475                 480 
Trp 
    

<210> 7
<211> 47
<212> PRT
<213> Saccharomyces


<400> 7
Met Gly Ser Ile Asn Asn Asn Phe Asn Thr Asn Asn Asn Ser Asn Thr 
1               5                   10                  15      
Asp Leu Asp Arg Asp Trp Lys Thr Ala Leu Asn Ile Pro Lys Lys Asp 
            20                  25                  30          
Thr Arg Pro Gln Thr Asp Asp Val Leu Asn Thr Lys Gly Asn Thr 
        35                  40                  45          

<210> 8
<211> 81
<212> PRT
<213> Saccharomyces


<400> 8
Val Pro Val Pro Phe Pro Ile Glu Gln Gln Ser Tyr His Gln Gln Ala 
1               5                   10                  15      
Ile Pro Gln Gln Gln Leu Pro Ser Gln Gln Gln Phe Ala Ile Pro Pro 
            20                  25                  30          
Gln Gln His His Pro Gln Phe Met Val Pro Pro Ser His Gln Gln Gln 
        35                  40                  45              
Gln Ala Tyr Pro Pro Pro Gln Met Pro Ser Gln Gln Gly Tyr Pro Pro 
    50                  55                  60                  
Gln Gln Glu His Phe Met Ala Met Pro Pro Gly Gln Ser Gln Pro Gln 
65                  70                  75                  80  
Tyr 
    

<210> 9
<211> 155
<212> PRT
<213> Saccharomyces


<400> 9
Met Ala Asp Leu Pro Gln Lys Val Ser Asn Leu Ser Ile Asn Asn Lys 
1               5                   10                  15      
Glu Asn Gly Gly Gly Gly Gly Lys Ser Ser Tyr Val Pro Pro His Leu 
            20                  25                  30          
Arg Ser Arg Gly Lys Pro Ser Phe Glu Arg Arg Ser Pro Lys Gln Lys 
        35                  40                  45              
Asp Lys Val Thr Gly Gly Asp Phe Phe Arg Arg Ala Gly Arg Gln Thr 
    50                  55                  60                  
Gly Asn Asn Gly Gly Phe Phe Gly Phe Ser Lys Glu Arg Asn Gly Gly 
65                  70                  75                  80  
Thr Ser Ala Asn Tyr Asn Arg Arg Gly Ser Ser Asn Tyr Lys Ser Ser 
                85                  90                  95      
Gly Asn Arg Trp Val Asn Gly Lys His Ile Pro Gly Pro Lys Asn Ala 
            100                 105                 110         
Lys Leu Gln Lys Ala Glu Leu Phe Gly Val His Asp Asp Pro Asp Tyr 
        115                 120                 125             
His Ser Ser Gly Ile Lys Phe Asp Asn Tyr Asp Asn Ile Pro Val Asp 
    130                 135                 140                 
Ala Ser Gly Lys Asp Val Pro Glu Pro Ile Leu 
145                 150                 155 

<210> 10
<211> 67
<212> PRT
<213> Saccharomyces


<400> 10
Gly Gly Arg Thr Arg Gly Gly Gly Gly Phe Phe Asn Ser Arg Asn Asn 
1               5                   10                  15      
Gly Ser Arg Asp Tyr Arg Lys His Gly Gly Asn Gly Ser Phe Gly Ser 
            20                  25                  30          
Thr Arg Pro Arg Asn Thr Gly Thr Ser Asn Trp Gly Ser Ile Gly Gly 
        35                  40                  45              
Gly Phe Arg Asn Asp Asn Glu Lys Asn Gly Tyr Gly Asn Ser Asn Ala 
    50                  55                  60                  
Ser Trp Trp 
65          

<210> 11
<211> 168
<212> PRT
<213> Caenorhabditis elegans


<400> 11
Met Glu Ser Asn Gln Ser Asn Asn Gly Gly Ser Gly Asn Ala Ala Leu 
1               5                   10                  15      
Asn Arg Gly Gly Arg Tyr Val Pro Pro His Leu Arg Gly Gly Asp Gly 
            20                  25                  30          
Gly Ala Ala Ala Ala Ala Ser Ala Gly Gly Asp Asp Arg Arg Gly Gly 
        35                  40                  45              
Ala Gly Gly Gly Gly Tyr Arg Arg Gly Gly Gly Asn Ser Gly Gly Gly 
    50                  55                  60                  
Gly Gly Gly Gly Tyr Asp Arg Gly Tyr Asn Asp Asn Arg Asp Asp Arg 
65                  70                  75                  80  
Asp Asn Arg Gly Gly Ser Gly Gly Tyr Gly Arg Asp Arg Asn Tyr Glu 
                85                  90                  95      
Asp Arg Gly Tyr Asn Gly Gly Gly Gly Gly Gly Gly Asn Arg Gly Tyr 
            100                 105                 110         
Asn Asn Asn Arg Gly Gly Gly Gly Gly Gly Tyr Asn Arg Gln Asp Arg 
        115                 120                 125             
Gly Asp Gly Gly Ser Ser Asn Phe Ser Arg Gly Gly Tyr Asn Asn Arg 
    130                 135                 140                 
Asp Glu Gly Ser Asp Asn Arg Gly Ser Gly Arg Ser Tyr Asn Asn Asp 
145                 150                 155                 160 
Arg Arg Asp Asn Gly Gly Asp Gly 
                165             

<210> 12
<211> 236
<212> PRT
<213> Homo sapiens


<400> 12
Met Gly Asp Glu Asp Trp Glu Ala Glu Ile Asn Pro His Met Ser Ser 
1               5                   10                  15      
Tyr Val Pro Ile Phe Glu Lys Asp Arg Tyr Ser Gly Glu Asn Gly Asp 
            20                  25                  30          
Asn Phe Asn Arg Thr Pro Ala Ser Ser Ser Glu Met Asp Asp Gly Pro 
        35                  40                  45              
Ser Arg Arg Asp His Phe Met Lys Ser Gly Phe Ala Ser Gly Arg Asn 
    50                  55                  60                  
Phe Gly Asn Arg Asp Ala Gly Glu Cys Asn Lys Arg Asp Asn Thr Ser 
65                  70                  75                  80  
Thr Met Gly Gly Phe Gly Val Gly Lys Ser Phe Gly Asn Arg Gly Phe 
                85                  90                  95      
Ser Asn Ser Arg Phe Glu Asp Gly Asp Ser Ser Gly Phe Trp Arg Glu 
            100                 105                 110         
Ser Ser Asn Asp Cys Glu Asp Asn Pro Thr Arg Asn Arg Gly Phe Ser 
        115                 120                 125             
Lys Arg Gly Gly Tyr Arg Asp Gly Asn Asn Ser Glu Ala Ser Gly Pro 
    130                 135                 140                 
Tyr Arg Arg Gly Gly Arg Gly Ser Phe Arg Gly Cys Arg Gly Gly Phe 
145                 150                 155                 160 
Gly Leu Gly Ser Pro Asn Asn Asp Leu Asp Pro Asp Glu Cys Met Gln 
                165                 170                 175     
Arg Thr Gly Gly Leu Phe Gly Ser Arg Arg Pro Val Leu Ser Gly Thr 
            180                 185                 190         
Gly Asn Gly Asp Thr Ser Gln Ser Arg Ser Gly Ser Gly Ser Glu Arg 
        195                 200                 205             
Gly Gly Tyr Lys Gly Leu Asn Glu Glu Val Ile Thr Gly Ser Gly Lys 
    210                 215                 220                 
Asn Ser Trp Lys Ser Glu Ala Glu Gly Gly Glu Ser 
225                 230                 235     

<210> 13
<211> 214
<212> PRT
<213> Homo sapiens


<400> 13
Met Ala Ser Asn Asp Tyr Thr Gln Gln Ala Thr Gln Ser Tyr Gly Ala 
1               5                   10                  15      
Tyr Pro Thr Gln Pro Gly Gln Gly Tyr Ser Gln Gln Ser Ser Gln Pro 
            20                  25                  30          
Tyr Gly Gln Gln Ser Tyr Ser Gly Tyr Ser Gln Ser Thr Asp Thr Ser 
        35                  40                  45              
Gly Tyr Gly Gln Ser Ser Tyr Ser Ser Tyr Gly Gln Ser Gln Asn Thr 
    50                  55                  60                  
Gly Tyr Gly Thr Gln Ser Thr Pro Gln Gly Tyr Gly Ser Thr Gly Gly 
65                  70                  75                  80  
Tyr Gly Ser Ser Gln Ser Ser Gln Ser Ser Tyr Gly Gln Gln Ser Ser 
                85                  90                  95      
Tyr Pro Gly Tyr Gly Gln Gln Pro Ala Pro Ser Ser Thr Ser Gly Ser 
            100                 105                 110         
Tyr Gly Ser Ser Ser Gln Ser Ser Ser Tyr Gly Gln Pro Gln Ser Gly 
        115                 120                 125             
Ser Tyr Ser Gln Gln Pro Ser Tyr Gly Gly Gln Gln Gln Ser Tyr Gly 
    130                 135                 140                 
Gln Gln Gln Ser Tyr Asn Pro Pro Gln Gly Tyr Gly Gln Gln Asn Gln 
145                 150                 155                 160 
Tyr Asn Ser Ser Ser Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Asn 
                165                 170                 175     
Tyr Gly Gln Asp Gln Ser Ser Met Ser Ser Gly Gly Gly Ser Gly Gly 
            180                 185                 190         
Gly Tyr Gly Asn Gln Asp Gln Ser Gly Gly Gly Gly Ser Gly Gly Tyr 
        195                 200                 205             
Gly Gln Gln Asp Arg Gly 
    210                 

<210> 14
<211> 186
<212> PRT
<213> Homo sapiens


<400> 14
Ala Ser Ala Ser Ser Ser Gln Arg Gly Arg Ser Gly Ser Gly Asn Phe 
1               5                   10                  15      
Gly Gly Gly Arg Gly Gly Gly Phe Gly Gly Asn Asp Asn Phe Gly Arg 
            20                  25                  30          
Gly Gly Asn Phe Ser Gly Arg Gly Gly Phe Gly Gly Ser Arg Gly Gly 
        35                  40                  45              
Gly Gly Tyr Gly Gly Ser Gly Asp Gly Tyr Asn Gly Phe Gly Asn Asp 
    50                  55                  60                  
Gly Gly Tyr Gly Gly Gly Gly Pro Gly Tyr Ser Gly Gly Ser Arg Gly 
65                  70                  75                  80  
Tyr Gly Ser Gly Gly Gln Gly Tyr Gly Asn Gln Gly Ser Gly Tyr Gly 
                85                  90                  95      
Gly Ser Gly Ser Tyr Asp Ser Tyr Asn Asn Gly Gly Gly Gly Gly Phe 
            100                 105                 110         
Gly Gly Gly Ser Gly Ser Asn Phe Gly Gly Gly Gly Ser Tyr Asn Asp 
        115                 120                 125             
Phe Gly Asn Tyr Asn Asn Gln Ser Ser Asn Phe Gly Pro Met Lys Gly 
    130                 135                 140                 
Gly Asn Phe Gly Gly Arg Ser Ser Gly Pro Tyr Gly Gly Gly Gly Gln 
145                 150                 155                 160 
Tyr Phe Ala Lys Pro Arg Asn Gln Gly Gly Tyr Gly Gly Ser Ser Ser 
                165                 170                 175     
Ser Ser Ser Tyr Gly Ser Gly Arg Arg Phe 
            180                 185     

<210> 15
<211> 152
<212> PRT
<213> Homo sapiens


<400> 15
Gly Arg Gly Gly Asn Phe Gly Phe Gly Asp Ser Arg Gly Gly Gly Gly 
1               5                   10                  15      
Asn Phe Gly Pro Gly Pro Gly Ser Asn Phe Arg Gly Gly Ser Asp Gly 
            20                  25                  30          
Tyr Gly Ser Gly Arg Gly Phe Gly Asp Gly Tyr Asn Gly Tyr Gly Gly 
        35                  40                  45              
Gly Pro Gly Gly Gly Asn Phe Gly Gly Ser Pro Gly Tyr Gly Gly Gly 
    50                  55                  60                  
Arg Gly Gly Tyr Gly Gly Gly Gly Pro Gly Tyr Gly Asn Gln Gly Gly 
65                  70                  75                  80  
Gly Tyr Gly Gly Gly Tyr Asp Asn Tyr Gly Gly Gly Asn Tyr Gly Ser 
                85                  90                  95      
Gly Asn Tyr Asn Asp Phe Gly Asn Tyr Asn Gln Gln Pro Ser Asn Tyr 
            100                 105                 110         
Gly Pro Met Lys Ser Gly Asn Phe Gly Gly Ser Arg Asn Met Gly Gly 
        115                 120                 125             
Pro Tyr Gly Gly Gly Asn Tyr Gly Pro Gly Gly Ser Gly Gly Ser Gly 
    130                 135                 140                 
Gly Tyr Gly Gly Arg Ser Arg Tyr 
145                 150         

<210> 16
<211> 570
<212> PRT
<213> Homo sapiens


<220> 
<223> Laf1-AK-Laf1

<400> 16
Met Gly Ser Ser His His His His His His Ser Ser Gly Leu Val Pro 
1               5                   10                  15      
Arg Gly Ser His Met Glu Ser Asn Gln Ser Asn Asn Gly Gly Ser Gly 
            20                  25                  30          
Asn Ala Ala Leu Asn Arg Gly Gly Arg Tyr Val Pro Pro His Leu Arg 
        35                  40                  45              
Gly Gly Asp Gly Gly Ala Ala Ala Ala Ala Ser Ala Gly Gly Asp Asp 
    50                  55                  60                  
Arg Arg Gly Gly Ala Gly Gly Gly Gly Tyr Arg Arg Gly Gly Gly Asn 
65                  70                  75                  80  
Ser Gly Gly Gly Gly Gly Gly Gly Tyr Asp Arg Gly Tyr Asn Asp Asn 
                85                  90                  95      
Arg Asp Asp Arg Asp Asn Arg Gly Gly Ser Gly Gly Tyr Gly Arg Asp 
            100                 105                 110         
Arg Asn Tyr Glu Asp Arg Gly Tyr Asn Gly Gly Gly Gly Gly Gly Gly 
        115                 120                 125             
Asn Arg Gly Tyr Asn Asn Asn Arg Gly Gly Gly Gly Gly Gly Tyr Asn 
    130                 135                 140                 
Arg Gln Asp Arg Gly Asp Gly Gly Ser Ser Asn Phe Ser Arg Gly Gly 
145                 150                 155                 160 
Tyr Asn Asn Arg Asp Glu Gly Ser Asp Asn Arg Gly Ser Gly Arg Ser 
                165                 170                 175     
Tyr Asn Asn Asp Arg Arg Asp Asn Gly Gly Asp Gly Met Arg Ile Ile 
            180                 185                 190         
Leu Leu Gly Ala Pro Gly Ala Gly Lys Gly Thr Gln Ala Gln Phe Ile 
        195                 200                 205             
Met Glu Lys Tyr Gly Ile Pro Gln Ile Ser Thr Gly Asp Met Leu Arg 
    210                 215                 220                 
Ala Ala Val Lys Ser Gly Ser Glu Leu Gly Lys Gln Ala Lys Asp Ile 
225                 230                 235                 240 
Met Asp Ala Gly Lys Leu Val Thr Asp Glu Leu Val Ile Ala Leu Val 
                245                 250                 255     
Lys Glu Arg Ile Ala Gln Glu Asp Cys Arg Asn Gly Phe Leu Leu Asp 
            260                 265                 270         
Gly Phe Pro Arg Thr Ile Pro Gln Ala Asp Ala Met Lys Glu Ala Gly 
        275                 280                 285             
Ile Asn Val Asp Tyr Val Leu Glu Phe Asp Val Pro Asp Glu Leu Ile 
    290                 295                 300                 
Val Asp Arg Ile Val Gly Arg Arg Val His Ala Pro Ser Gly Arg Val 
305                 310                 315                 320 
Tyr His Val Lys Phe Asn Pro Pro Lys Val Glu Gly Lys Asp Asp Val 
                325                 330                 335     
Thr Gly Glu Glu Leu Thr Thr Arg Lys Asp Asp Gln Glu Glu Thr Val 
            340                 345                 350         
Arg Lys Arg Leu Val Glu Tyr His Gln Met Thr Ala Pro Leu Ile Gly 
        355                 360                 365             
Tyr Tyr Ser Lys Glu Ala Glu Ala Gly Asn Thr Lys Tyr Ala Lys Val 
    370                 375                 380                 
Asp Gly Thr Lys Pro Val Ala Glu Val Arg Ala Asp Leu Glu Lys Ile 
385                 390                 395                 400 
Leu Gly Met Glu Ser Asn Gln Ser Asn Asn Gly Gly Ser Gly Asn Ala 
                405                 410                 415     
Ala Leu Asn Arg Gly Gly Arg Tyr Val Pro Pro His Leu Arg Gly Gly 
            420                 425                 430         
Asp Gly Gly Ala Ala Ala Ala Ala Ser Ala Gly Gly Asp Asp Arg Arg 
        435                 440                 445             
Gly Gly Ala Gly Gly Gly Gly Tyr Arg Arg Gly Gly Gly Asn Ser Gly 
    450                 455                 460                 
Gly Gly Gly Gly Gly Gly Tyr Asp Arg Gly Tyr Asn Asp Asn Arg Asp 
465                 470                 475                 480 
Asp Arg Asp Asn Arg Gly Gly Ser Gly Gly Tyr Gly Arg Asp Arg Asn 
                485                 490                 495     
Tyr Glu Asp Arg Gly Tyr Asn Gly Gly Gly Gly Gly Gly Gly Asn Arg 
            500                 505                 510         
Gly Tyr Asn Asn Asn Arg Gly Gly Gly Gly Gly Gly Tyr Asn Arg Gln 
        515                 520                 525             
Asp Arg Gly Asp Gly Gly Ser Ser Asn Phe Ser Arg Gly Gly Tyr Asn 
    530                 535                 540                 
Asn Arg Asp Glu Gly Ser Asp Asn Arg Gly Ser Gly Arg Ser Tyr Asn 
545                 550                 555                 560 
Asn Asp Arg Arg Asp Asn Gly Gly Asp Gly 
                565                 570 

