                         SEQUENCE LISTING

<110>  Institut National de la Recherche Agronomique (INRA)
       l'Universidade Federal De Minas Gerais (UFMG)
       l'Institut Suprieur des Sciences Agronomiques, 
       Agroalimentaires, Horticoles et du Paysage  (Agro campus Ouest)
       X, X
 
<120>  NOUVEAU TRAITEMENT DE LA MUCITE

<130>  INR-B-0022-PCT1

<150>  FR18/70991
<151>  2018-09-05

<160>  7     

<170>  PatentIn version 3.5

<210>  1
<211>  556
<212>  PRT
<213>  Propionibacterium freudenreichii

<400>  1

Met Ser Val Arg Lys Ser Leu Thr Gly Met Ala Leu Gly Leu Ala Leu 
1               5                   10                  15      


Thr Ile Thr Pro Leu Ala Gly Ala Val Pro Ala Ser Ala Asp Thr Ala 
            20                  25                  30          


Pro Ala Pro Lys Asp Ala Ile Thr Lys Ala Ala Asp Trp Leu Val Asn 
        35                  40                  45              


Asp Tyr Asn Thr Asn Cys Leu Gly Asp Lys Gln Thr Ser Tyr Ser Cys 
    50                  55                  60                  


Ser Asn Gly Gly Leu Ala Asp Val Ile Leu Ala Leu Ser Ser Thr Gly 
65                  70                  75                  80  


Asp Ala Lys Tyr Ala Asp Glu Ile Ser Thr Met Met Thr Asn Leu Ala 
                85                  90                  95      


Pro Gln Val Ala Ser Tyr Thr Lys Asp Asn Ala Gly Ala Thr Ala Lys 
            100                 105                 110         


Ile Ile Ile Thr Val Ile Ala Ala His Gln Lys Pro Ser Ala Phe Gly 
        115                 120                 125             


Gly Asn Asp Leu Val Gly Gln Leu Gln Ala Leu Asn Ala Glu Asn Pro 
    130                 135                 140                 


Ala Gly Gly Gly Ala Trp Gly Pro Gln Leu Ser Met Val Ala Leu Thr 
145                 150                 155                 160 


Arg Ala Gly Glu Thr Val Pro Glu Ala Leu Ile Asp Ala Thr Val Asp 
                165                 170                 175     


Lys Gln Asn Ser Lys Gly Gly Phe Gly Trp Gly Gly Asp Thr Gly Asp 
            180                 185                 190         


Gly Asp Asn Thr Ala Ile Gly Met Met Ala Thr Ala Ala Val Ala Lys 
        195                 200                 205             


Gly Asn Pro Arg Ala Ala Asp Ser Leu Ala Lys Ala Val Ala Trp Ala 
    210                 215                 220                 


Gln Asp Pro Ala Asn Leu Thr Thr Asp Asp Thr Gly Ser Tyr Trp Thr 
225                 230                 235                 240 


Asn Tyr Ser Pro Thr Asn Thr Ala Gly Met Met Leu Met Ala Ile Gly 
                245                 250                 255     


Asp Val Asn Asp Pro Lys Ile Asp Val Ser Lys Gln Met Asp Phe Leu 
            260                 265                 270         


Ile Gly Arg Gln Leu Pro Ser Gly Ala Phe Ser Asn Thr Leu Lys Gly 
        275                 280                 285             


Thr Asn Asp Asn Ala Met Ala Thr Ile Gln Ala Leu Gln Gly Leu Thr 
    290                 295                 300                 


Met His Gly Tyr Leu Thr Ala Ser Ala Gly Gln Lys Asn Asp Pro Gly 
305                 310                 315                 320 


Thr Gly Gly Gly Thr Thr Asp Pro Gly Thr Gly Gly Gly Thr Gly Gly 
                325                 330                 335     


Gly Ser Thr Gly Gly Gly Ser Thr Gly Gly Gly Gly Ser Thr Gly Gly 
            340                 345                 350         


Gly Gly Ser Thr Gly Gly Gly Gly Ser Thr Gly Gly Gly Gly Val Val 
        355                 360                 365             


Thr Pro Pro Val Thr Gln Ala Phe Thr Asp Val Ala Pro Ser Asn Met 
    370                 375                 380                 


Tyr Phe Thr Glu Ile Gln Trp Ala Ala Ala Asn Asn Val Thr Thr Gly 
385                 390                 395                 400 


Trp Lys Asn Ala Asp Gly Thr Ala Ser Phe Arg Pro Leu Asp Thr Thr 
                405                 410                 415     


His Arg Asp Ala Met Ala Ala Phe Leu Tyr Arg Leu Ser Gly Ser Pro 
            420                 425                 430         


Ser Tyr Thr Ala Pro Ala Thr Ser Pro Phe Thr Asp Val Asn Pro Ser 
        435                 440                 445             


Asn Gln Phe Tyr Lys Glu Ile Cys Trp Leu Ala Ser Gln Asn Ile Thr 
    450                 455                 460                 


Thr Gly Trp Pro Asp Gly Ser Phe Arg Pro Leu Asp Asn Val Asn Arg 
465                 470                 475                 480 


Asp Ala Met Ala Ala Phe Leu Tyr Arg Tyr Ser Gln Val Ser Gly Phe 
                485                 490                 495     


Gln Ala Pro Ala Ala Ser Pro Phe Ala Asp Val Thr Pro Gly Ser Gln 
            500                 505                 510         


Phe Tyr Thr Glu Met Ser Trp Leu Ser Ala Asn Gly Ile Ser Thr Gly 
        515                 520                 525             


Trp Pro Asp Gln Thr Phe Arg Pro Val Thr Pro Ile Ala Arg Asp Ala 
    530                 535                 540                 


Met Ile Thr Phe Ile Tyr Arg Met Lys His Ala Ser 
545                 550                 555     


<210>  2
<211>  556
<212>  PRT
<213>  Propionibacterium freudenreichii

<400>  2

Met Ser Val Arg Lys Ser Leu Thr Gly Met Ala Leu Gly Leu Ala Leu 
1               5                   10                  15      


Thr Ile Thr Pro Leu Ala Gly Ala Val Pro Ala Ser Ala Asp Thr Ala 
            20                  25                  30          


Pro Ala Pro Lys Asp Ala Ile Thr Lys Ala Ala Asp Trp Leu Val Asn 
        35                  40                  45              


Asp Tyr Asn Thr Asn Cys Leu Gly Asp Lys Gln Thr Ser Tyr Ser Cys 
    50                  55                  60                  


Ser Asn Gly Gly Leu Ala Asp Val Ile Leu Ala Leu Ser Ser Thr Gly 
65                  70                  75                  80  


Asp Ala Lys Tyr Ala Asp Glu Ile Ser Thr Met Met Ala Asn Leu Ala 
                85                  90                  95      


Pro Gln Val Ala Gly Tyr Thr Lys Asp Asn Ala Gly Ala Thr Ala Lys 
            100                 105                 110         


Ile Ile Ile Thr Ala Ile Ala Ala His Gln Lys Pro Ser Ala Phe Gly 
        115                 120                 125             


Gly Asn Asp Leu Val Gly Gln Leu Gln Ala Leu Asn Ala Glu Asn Pro 
    130                 135                 140                 


Ala Gly Gly Gly Ala Trp Gly Pro Gln Leu Ser Val Val Ala Leu Thr 
145                 150                 155                 160 


Arg Ala Gly Glu Thr Val Pro Glu Ala Val Val Asp Ala Thr Ile Ala 
                165                 170                 175     


Lys Gln Asn Ser Lys Gly Gly Phe Gly Trp Gly Gly Asp Thr Gly Asp 
            180                 185                 190         


Gly Asp Asn Thr Ala Ile Gly Met Met Ala Thr Ala Ala Val Ala Lys 
        195                 200                 205             


Gly Asn Pro Lys Ala Ala Asp Ser Leu Ala Lys Ala Val Gly Trp Ala 
    210                 215                 220                 


Gln Asp Pro Ala Asn Leu Thr Thr Asp Asp Thr Gly Ser Tyr Trp Thr 
225                 230                 235                 240 


Asn Tyr Ser Pro Thr Asn Thr Ala Gly Met Met Leu Met Ala Ile Gly 
                245                 250                 255     


Asp Val Asn Asp Pro Lys Ile Asp Val Ser Lys Gln Met Asp Phe Leu 
            260                 265                 270         


Ile Gly Arg Gln Leu Pro Ser Gly Ala Phe Ser Asn Thr Leu Lys Gly 
        275                 280                 285             


Thr Asn Asp Asn Ala Met Ala Thr Thr Gln Ala Leu Gln Gly Leu Thr 
    290                 295                 300                 


Met His Gly Tyr Leu Thr Ala Ser Ala Gly Gln Lys Thr Asp Pro Gly 
305                 310                 315                 320 


Thr Gly Gly Gly Thr Thr Asp Pro Gly Thr Gly Gly Gly Thr Gly Gly 
                325                 330                 335     


Gly Ser Thr Gly Gly Gly Ser Thr Gly Gly Gly Gly Ser Thr Gly Gly 
            340                 345                 350         


Gly Gly Ser Thr Gly Gly Gly Gly Ser Thr Gly Gly Gly Gly Val Val 
        355                 360                 365             


Thr Pro Pro Val Thr Gln Ala Phe Thr Asp Val Ala Pro Ser Asn Met 
    370                 375                 380                 


Tyr Phe Thr Glu Ile Gln Trp Ala Ala Ala Asn Asn Val Thr Thr Gly 
385                 390                 395                 400 


Trp Lys Asn Ala Asp Gly Thr Ala Ser Phe Arg Pro Leu Asp Thr Thr 
                405                 410                 415     


His Arg Asp Ala Met Ala Ala Phe Leu Tyr Arg Leu Ser Gly Ser Pro 
            420                 425                 430         


Ser Tyr Thr Ala Pro Ala Thr Ser Pro Phe Thr Asp Val Asn Pro Ser 
        435                 440                 445             


Asn Gln Phe Tyr Lys Glu Ile Cys Trp Leu Ala Ser Gln Asn Ile Thr 
    450                 455                 460                 


Thr Gly Trp Pro Asp Gly Ser Phe Arg Pro Leu Asp Asn Val Asn Arg 
465                 470                 475                 480 


Asp Ala Met Ala Ala Phe Leu Tyr Arg Tyr Ser Gln Val Ser Gly Phe 
                485                 490                 495     


Gln Ala Pro Ala Ala Ser Pro Phe Ala Asp Val Thr Pro Gly Ser Gln 
            500                 505                 510         


Phe Tyr Thr Glu Met Ser Trp Leu Ser Ala Asn Gly Ile Ser Thr Gly 
        515                 520                 525             


Trp Pro Asp Gln Thr Phe Arg Pro Val Thr Pro Ile Ala Arg Asp Ala 
    530                 535                 540                 


Met Ile Thr Phe Ile Tyr Arg Met Lys His Ala Ser 
545                 550                 555     


<210>  3
<211>  556
<212>  PRT
<213>  Propionibacterium freudenreichii

<400>  3

Met Ser Val Arg Lys Ser Leu Thr Gly Met Ala Leu Gly Leu Ala Leu 
1               5                   10                  15      


Thr Ile Thr Pro Leu Ala Gly Ala Val Pro Ala Ala Ala Asp Thr Ala 
            20                  25                  30          


Pro Ala Pro Lys Asp Ala Ile Thr Lys Ala Ala Asp Trp Leu Val Asn 
        35                  40                  45              


Asp Tyr Asn Thr Asn Cys Leu Gly Asp Lys Gln Thr Ser Tyr Ser Cys 
    50                  55                  60                  


Ser Asn Gly Gly Leu Ala Glu Val Ile Leu Ala Leu Ser Ser Thr Gly 
65                  70                  75                  80  


Asp Ala Lys Tyr Ala Asp Glu Ile Ser Thr Met Met Ala Asn Leu Ala 
                85                  90                  95      


Pro Gln Val Ala Gly Tyr Thr Lys Asp Asn Ala Gly Ala Thr Ala Lys 
            100                 105                 110         


Ile Ile Ile Thr Ala Ile Ala Ala His Gln Lys Pro Ser Ala Phe Gly 
        115                 120                 125             


Gly Asn Asp Leu Val Gly Gln Leu Gln Ala Leu Asn Ala Glu Asn Pro 
    130                 135                 140                 


Ala Gly Gly Gly Ala Trp Gly Pro Gln Leu Ser Val Val Ala Leu Thr 
145                 150                 155                 160 


Arg Ala Gly Glu Thr Val Pro Glu Ala Val Val Asp Ala Thr Ile Ala 
                165                 170                 175     


Lys Gln Asn Ser Lys Gly Gly Phe Gly Trp Gly Gly Asp Thr Gly Asp 
            180                 185                 190         


Gly Asp Asn Thr Ala Ile Gly Met Met Ala Thr Ala Ala Val Ala Lys 
        195                 200                 205             


Gly Asn Pro Lys Ala Ala Asp Ser Leu Ala Lys Ala Val Gly Trp Ala 
    210                 215                 220                 


Gln Asp Pro Ala Asn Leu Thr Thr Asp Asp Thr Gly Ser Tyr Trp Thr 
225                 230                 235                 240 


Asn Tyr Ser Pro Thr Asn Thr Ala Gly Met Met Leu Met Ala Ile Gly 
                245                 250                 255     


Asp Val Asn Asp Pro Lys Ile Asp Val Ser Lys Gln Met Asp Phe Leu 
            260                 265                 270         


Ile Gly Arg Gln Leu Pro Ser Gly Ala Phe Ser Asn Thr Leu Lys Gly 
        275                 280                 285             


Thr Asn Asp Asn Ala Met Ala Thr Thr Gln Ala Leu Gln Gly Leu Thr 
    290                 295                 300                 


Met His Gly Tyr Leu Thr Ala Ser Ala Gly Gln Lys Thr Asp Pro Gly 
305                 310                 315                 320 


Thr Gly Gly Gly Thr Thr Asp Pro Gly Thr Gly Gly Gly Thr Gly Gly 
                325                 330                 335     


Gly Ser Thr Gly Gly Gly Ser Thr Gly Gly Gly Gly Ser Thr Gly Gly 
            340                 345                 350         


Gly Gly Ser Thr Gly Gly Gly Gly Ser Thr Gly Gly Gly Gly Val Val 
        355                 360                 365             


Thr Pro Pro Val Thr Gln Ala Phe Thr Asp Val Ala Pro Ser Asn Met 
    370                 375                 380                 


Tyr Phe Thr Glu Ile Gln Trp Ala Ala Ala Asn Asn Val Thr Thr Gly 
385                 390                 395                 400 


Trp Lys Asn Ala Asp Gly Thr Ala Ser Phe Arg Pro Leu Asp Thr Thr 
                405                 410                 415     


His Arg Asp Ala Met Ala Ala Phe Leu Tyr Arg Leu Ser Gly Ser Pro 
            420                 425                 430         


Ser Tyr Thr Ala Pro Ala Thr Ser Pro Phe Thr Asp Val Asn Pro Ser 
        435                 440                 445             


Asn Gln Phe Tyr Lys Glu Ile Cys Trp Leu Ala Ser Gln Asn Ile Thr 
    450                 455                 460                 


Thr Gly Trp Pro Asp Gly Ser Phe Arg Pro Leu Asp Asn Val Asn Arg 
465                 470                 475                 480 


Asp Ala Met Ala Ala Phe Leu Tyr Arg Tyr Ser Gln Val Ser Gly Phe 
                485                 490                 495     


Gln Ala Pro Ala Ala Ser Pro Phe Ala Asp Val Thr Pro Gly Ser Gln 
            500                 505                 510         


Phe Tyr Thr Glu Met Ser Trp Leu Ser Ala Asn Gly Ile Ser Thr Gly 
        515                 520                 525             


Trp Pro Asp Gln Thr Phe Arg Pro Val Thr Pro Ile Ala Arg Asp Ala 
    530                 535                 540                 


Met Ile Thr Phe Ile Tyr Arg Met Lys His Ala Ser 
545                 550                 555     


<210>  4
<211>  556
<212>  PRT
<213>  Propionibacterium freudenreichii

<400>  4

Met Ser Val Arg Lys Ser Leu Thr Gly Met Ala Leu Gly Leu Ala Leu 
1               5                   10                  15      


Thr Ile Thr Pro Leu Ala Gly Ala Val Pro Ala Ser Ala Asp Thr Ala 
            20                  25                  30          


Pro Ala Pro Lys Asp Ala Ile Thr Lys Ala Ala Asp Arg Leu Val Asn 
        35                  40                  45              


Asp Tyr Asn Thr Asn Cys Leu Gly Asp Lys Gln Thr Ser Tyr Ser Cys 
    50                  55                  60                  


Ser Asn Gly Gly Leu Ala Asp Val Ile Leu Ala Leu Ser Ser Thr Gly 
65                  70                  75                  80  


Asp Ala Lys Tyr Ala Asp Glu Ile Ser Thr Met Met Ala Asn Leu Ala 
                85                  90                  95      


Pro Gln Val Ala Gly Tyr Thr Lys Asp Asn Ala Gly Ala Thr Ala Lys 
            100                 105                 110         


Ile Ile Ile Thr Ala Ile Ala Ala His Gln Lys Pro Ser Ala Phe Gly 
        115                 120                 125             


Gly Asn Asp Leu Val Gly Gln Leu Glu Ala Leu Asn Ala Glu Asn Pro 
    130                 135                 140                 


Ala Gly Gly Gly Ala Trp Gly Pro Gln Leu Ser Val Val Ala Leu Thr 
145                 150                 155                 160 


Arg Ala Gly Glu Thr Val Pro Glu Ala Val Val Asp Ala Thr Ile Ala 
                165                 170                 175     


Lys Gln Asn Ser Lys Gly Gly Phe Gly Trp Gly Gly Asp Thr Gly Asp 
            180                 185                 190         


Gly Asp Asn Thr Ala Ile Gly Met Met Ala Thr Ala Ala Val Ala Lys 
        195                 200                 205             


Gly Asn Pro Lys Ala Ala Asp Ser Leu Ala Lys Ala Val Gly Trp Ala 
    210                 215                 220                 


Gln Asp Pro Ala Asn Leu Thr Thr Asp Asp Thr Gly Ser Tyr Trp Thr 
225                 230                 235                 240 


Asn Tyr Ser Pro Thr Asn Thr Ala Gly Met Met Leu Met Ala Ile Gly 
                245                 250                 255     


Asp Val Asn Asp Pro Lys Ile Asp Val Ser Lys Gln Met Asp Phe Leu 
            260                 265                 270         


Ile Gly Arg Gln Leu Pro Ser Gly Ala Phe Ser Asn Thr Leu Lys Gly 
        275                 280                 285             


Thr Asn Asp Asn Ala Met Ala Thr Thr Gln Ala Leu Gln Gly Leu Thr 
    290                 295                 300                 


Met His Gly Tyr Leu Thr Ala Ser Ala Gly Gln Lys Thr Asp Pro Gly 
305                 310                 315                 320 


Thr Gly Gly Gly Thr Thr Asp Pro Gly Thr Gly Gly Gly Thr Gly Gly 
                325                 330                 335     


Gly Ser Thr Gly Gly Gly Ser Thr Gly Gly Gly Gly Ser Thr Gly Gly 
            340                 345                 350         


Gly Gly Ser Thr Gly Gly Gly Gly Ser Thr Gly Gly Gly Gly Val Val 
        355                 360                 365             


Thr Pro Pro Val Thr Gln Ala Phe Thr Asp Val Ala Pro Ser Asn Met 
    370                 375                 380                 


Tyr Phe Thr Glu Ile Gln Trp Ala Ala Ala Asn Asn Val Thr Thr Gly 
385                 390                 395                 400 


Trp Lys Asn Ala Asp Gly Thr Ala Ser Phe Arg Pro Leu Asp Thr Thr 
                405                 410                 415     


His Arg Asp Ala Met Ala Ala Phe Leu Tyr Arg Leu Ser Gly Ser Pro 
            420                 425                 430         


Ser Tyr Thr Ala Pro Ala Thr Ser Pro Phe Thr Asp Val Asn Pro Ser 
        435                 440                 445             


Asn Gln Phe Tyr Lys Glu Ile Cys Trp Leu Ala Ser Gln Asn Ile Thr 
    450                 455                 460                 


Thr Gly Trp Pro Asp Gly Ser Phe Arg Pro Leu Asp Asn Val Asn Arg 
465                 470                 475                 480 


Asp Ala Met Ala Ala Phe Leu Tyr Arg Tyr Ser Gln Val Ser Gly Phe 
                485                 490                 495     


Gln Ala Pro Ala Ala Ser Pro Phe Ala Asp Val Thr Pro Gly Ser Gln 
            500                 505                 510         


Phe Tyr Thr Glu Met Ser Trp Leu Ser Ala Asn Gly Ile Ser Thr Gly 
        515                 520                 525             


Trp Pro Asp Gln Thr Phe Arg Pro Val Thr Pro Ile Ala Arg Asp Ala 
    530                 535                 540                 


Met Ile Thr Phe Ile Tyr Arg Met Lys His Ala Ser 
545                 550                 555     


<210>  5
<211>  580
<212>  PRT
<213>  Propionibacterium freudenreichii

<400>  5

Met Asp Ala Ser Ser Ala Pro Met Pro Pro Ser Ala Pro Gly Ser Pro 
1               5                   10                  15      


Cys Gly Pro Ser Ser Trp Thr Thr His Glu Arg Phe Pro Phe Met Ser 
            20                  25                  30          


Val Arg Lys Ser Leu Thr Gly Met Ala Leu Gly Leu Ala Leu Thr Ile 
        35                  40                  45              


Thr Pro Leu Ala Gly Ala Val Pro Ala Ser Ala Asp Thr Ala Pro Ala 
    50                  55                  60                  


Pro Lys Asp Ala Ile Thr Lys Ala Ala Asp Trp Leu Val Asn Asp Tyr 
65                  70                  75                  80  


Asn Thr Asn Cys Leu Gly Asp Lys Gln Thr Ser Tyr Ser Cys Ser Asn 
                85                  90                  95      


Gly Gly Leu Ala Asp Val Ile Leu Ala Leu Ser Ser Thr Gly Asp Ala 
            100                 105                 110         


Lys Tyr Ala Asp Glu Ile Ser Thr Met Met Ala Asn Leu Ala Pro Gln 
        115                 120                 125             


Val Ala Gly Tyr Thr Lys Asp Asn Ala Gly Ala Thr Ala Lys Ile Ile 
    130                 135                 140                 


Ile Thr Ala Ile Ala Ala His Gln Lys Pro Ser Ala Phe Gly Gly Asn 
145                 150                 155                 160 


Asp Leu Val Gly Gln Leu Gln Ala Leu Asn Ala Glu Asn Pro Ala Gly 
                165                 170                 175     


Gly Gly Ala Trp Gly Pro Gln Leu Ser Val Val Ala Leu Thr Arg Ala 
            180                 185                 190         


Gly Glu Thr Val Pro Glu Ala Val Val Asp Ala Thr Ile Ala Lys Gln 
        195                 200                 205             


Asn Ser Lys Gly Gly Phe Gly Trp Gly Gly Asp Thr Gly Asp Gly Asp 
    210                 215                 220                 


Asn Thr Ala Ile Gly Met Met Ala Thr Ala Ala Val Ala Lys Gly Asn 
225                 230                 235                 240 


Pro Lys Ala Ala Asp Ser Leu Ala Lys Ala Val Gly Trp Ala Gln Asp 
                245                 250                 255     


Pro Ala Asn Leu Thr Thr Asp Asp Thr Gly Ser Tyr Trp Thr Asn Tyr 
            260                 265                 270         


Ser Pro Thr Asn Thr Ala Gly Met Met Leu Met Ala Ile Gly Asp Val 
        275                 280                 285             


Asn Asp Pro Lys Ile Asp Val Ser Lys Gln Met Asp Phe Leu Ile Gly 
    290                 295                 300                 


Arg Gln Leu Pro Ser Gly Ala Phe Ser Asn Thr Leu Lys Gly Thr Asn 
305                 310                 315                 320 


Asp Asn Ala Met Ala Thr Thr Gln Ala Leu Gln Gly Leu Thr Met His 
                325                 330                 335     


Gly Tyr Leu Thr Ala Ser Ala Gly Gln Lys Thr Asp Pro Gly Thr Gly 
            340                 345                 350         


Gly Gly Thr Thr Asp Pro Gly Thr Gly Gly Gly Thr Gly Gly Gly Ser 
        355                 360                 365             


Thr Gly Gly Gly Ser Thr Gly Gly Gly Gly Ser Thr Gly Gly Gly Gly 
    370                 375                 380                 


Ser Thr Gly Gly Gly Gly Val Val Thr Pro Pro Val Thr Gln Ala Phe 
385                 390                 395                 400 


Thr Asp Val Ala Pro Ser Asn Met Tyr Phe Thr Glu Ile Gln Trp Ala 
                405                 410                 415     


Ala Ala Asn Asn Val Thr Thr Gly Trp Lys Asn Ala Asp Gly Thr Ala 
            420                 425                 430         


Ser Phe Arg Pro Leu Asp Thr Thr His Arg Asp Ala Met Ala Ala Phe 
        435                 440                 445             


Leu Tyr Arg Leu Ser Gly Ser Pro Ser Tyr Thr Ala Pro Ala Thr Ser 
    450                 455                 460                 


Pro Phe Thr Asp Val Asn Pro Ser Asn Gln Phe Tyr Lys Glu Ile Cys 
465                 470                 475                 480 


Trp Leu Ala Ser Gln Asn Ile Thr Thr Gly Trp Pro Asp Gly Ser Phe 
                485                 490                 495     


Arg Pro Leu Asp Asn Val Asn Arg Asp Ala Met Ala Ala Phe Leu Tyr 
            500                 505                 510         


Arg Tyr Ser Gln Val Ser Gly Phe Gln Ala Pro Ala Ala Ser Pro Phe 
        515                 520                 525             


Ala Asp Val Thr Pro Gly Ser Gln Phe Tyr Thr Glu Met Ser Trp Leu 
    530                 535                 540                 


Ser Ala Asn Gly Ile Ser Thr Gly Trp Pro Asp Gln Thr Phe Arg Pro 
545                 550                 555                 560 


Val Thr Pro Ile Ala Arg Asp Ala Met Ile Thr Phe Ile Tyr Arg Met 
                565                 570                 575     


Lys His Ala Ser 
            580 


<210>  6
<211>  547
<212>  PRT
<213>  Propionibacterium freudenreichii

<400>  6

Met Ala Leu Gly Leu Ala Leu Thr Ile Thr Pro Leu Ala Gly Ala Val 
1               5                   10                  15      


Pro Ala Ser Ala Asp Thr Ala Pro Ala Pro Lys Asp Ala Ile Thr Lys 
            20                  25                  30          


Ala Ala Asp Trp Leu Val Asn Asp Tyr Asn Thr Asn Cys Leu Gly Asp 
        35                  40                  45              


Lys Gln Thr Ser Tyr Ser Cys Ser Asn Gly Gly Leu Ala Asp Val Ile 
    50                  55                  60                  


Leu Ala Leu Ser Ser Thr Gly Asp Ala Lys Tyr Ala Asp Glu Ile Ser 
65                  70                  75                  80  


Thr Met Met Ala Asn Leu Ala Pro Gln Val Ala Gly Tyr Thr Lys Asp 
                85                  90                  95      


Asn Ala Gly Ala Thr Ala Lys Ile Ile Ile Thr Ala Ile Ala Ala His 
            100                 105                 110         


Gln Lys Pro Ser Ala Phe Gly Gly Asn Asp Leu Val Gly Gln Leu Gln 
        115                 120                 125             


Ala Leu Asn Ala Glu Asn Pro Ala Gly Gly Gly Ala Trp Gly Pro Gln 
    130                 135                 140                 


Leu Ser Val Val Ala Leu Thr Arg Ala Gly Glu Thr Val Pro Glu Ala 
145                 150                 155                 160 


Val Val Asp Ala Thr Ile Ala Lys Gln Asn Ser Lys Gly Gly Phe Gly 
                165                 170                 175     


Trp Gly Gly Asp Thr Gly Asp Gly Asp Asn Thr Ala Ile Gly Met Met 
            180                 185                 190         


Ala Thr Ala Ala Val Ala Lys Gly Asn Pro Lys Ala Ala Asp Ser Leu 
        195                 200                 205             


Ala Lys Ala Val Gly Trp Ala Gln Asp Pro Ala Asn Leu Thr Thr Asp 
    210                 215                 220                 


Asp Thr Gly Ser Tyr Trp Thr Asn Tyr Ser Pro Thr Asn Thr Ala Gly 
225                 230                 235                 240 


Met Met Leu Met Ala Ile Gly Asp Val Asn Asp Pro Lys Ile Asp Val 
                245                 250                 255     


Ser Lys Gln Met Asp Phe Leu Ile Gly Arg Gln Leu Pro Ser Gly Ala 
            260                 265                 270         


Phe Ser Asn Thr Leu Lys Gly Thr Asn Asp Asn Ala Met Ala Thr Thr 
        275                 280                 285             


Gln Ala Leu Gln Gly Leu Thr Met His Gly Tyr Leu Thr Ala Ser Ala 
    290                 295                 300                 


Gly Gln Lys Thr Asp Pro Gly Thr Gly Gly Gly Thr Thr Asp Pro Gly 
305                 310                 315                 320 


Thr Gly Gly Gly Thr Gly Gly Gly Ser Thr Gly Gly Gly Ser Thr Gly 
                325                 330                 335     


Gly Gly Gly Ser Thr Gly Gly Gly Gly Ser Thr Gly Gly Gly Gly Ser 
            340                 345                 350         


Thr Gly Gly Gly Gly Val Val Thr Pro Pro Val Thr Gln Ala Phe Thr 
        355                 360                 365             


Asp Val Ala Pro Ser Asn Met Tyr Phe Thr Glu Ile Gln Trp Ala Ala 
    370                 375                 380                 


Ala Asn Asn Val Thr Thr Gly Trp Lys Asn Ala Asp Gly Thr Ala Ser 
385                 390                 395                 400 


Phe Arg Pro Leu Asp Thr Thr His Arg Asp Ala Met Ala Ala Phe Leu 
                405                 410                 415     


Tyr Arg Leu Ser Gly Ser Pro Ser Tyr Thr Ala Pro Ala Thr Ser Pro 
            420                 425                 430         


Phe Thr Asp Val Asn Pro Ser Asn Gln Phe Tyr Lys Glu Ile Cys Trp 
        435                 440                 445             


Leu Ala Ser Gln Asn Ile Thr Thr Gly Trp Pro Asp Gly Ser Phe Arg 
    450                 455                 460                 


Pro Leu Asp Asn Val Asn Arg Asp Ala Met Ala Ala Phe Leu Tyr Arg 
465                 470                 475                 480 


Tyr Ser Gln Val Ser Gly Phe Gln Ala Pro Ala Ala Ser Pro Phe Ala 
                485                 490                 495     


Asp Val Thr Pro Gly Ser Gln Phe Tyr Thr Glu Met Ser Trp Leu Ser 
            500                 505                 510         


Ala Asn Gly Ile Ser Thr Gly Trp Pro Asp Gln Thr Phe Arg Pro Val 
        515                 520                 525             


Thr Pro Ile Ala Arg Asp Ala Met Ile Thr Phe Ile Tyr Arg Met Lys 
    530                 535                 540                 


His Ala Ser 
545         


<210>  7
<211>  547
<212>  PRT
<213>  Propionibacterium freudenreichii

<400>  7

Met Ala Leu Gly Leu Ala Leu Thr Ile Thr Pro Leu Ala Gly Ala Val 
1               5                   10                  15      


Pro Ala Ala Ala Asp Thr Ala Pro Ala Pro Lys Asp Ala Ile Thr Lys 
            20                  25                  30          


Ala Ala Asp Trp Leu Val Asn Asp Tyr Asn Thr Asn Cys Leu Gly Asp 
        35                  40                  45              


Lys Gln Thr Ser Tyr Ser Cys Ser Asn Gly Gly Leu Ala Glu Val Ile 
    50                  55                  60                  


Leu Ala Leu Ser Ser Thr Gly Asp Ala Lys Tyr Ala Asp Glu Ile Ser 
65                  70                  75                  80  


Thr Met Met Ala Asn Leu Ala Pro Gln Val Ala Gly Tyr Thr Lys Asp 
                85                  90                  95      


Asn Ala Gly Ala Thr Ala Lys Ile Ile Ile Thr Ala Ile Ala Ala His 
            100                 105                 110         


Gln Lys Pro Ser Ala Phe Gly Gly Asn Asp Leu Val Gly Gln Leu Gln 
        115                 120                 125             


Ala Leu Asn Ala Glu Asn Pro Ala Gly Gly Gly Ala Trp Gly Pro Gln 
    130                 135                 140                 


Leu Ser Val Val Ala Leu Thr Arg Ala Gly Glu Thr Val Pro Glu Ala 
145                 150                 155                 160 


Val Val Asp Ala Thr Ile Ala Lys Gln Asn Ser Lys Gly Gly Phe Gly 
                165                 170                 175     


Trp Gly Gly Asp Thr Gly Asp Gly Asp Asn Thr Ala Ile Gly Met Met 
            180                 185                 190         


Ala Thr Ala Ala Val Ala Lys Gly Asn Pro Lys Ala Ala Asp Ser Leu 
        195                 200                 205             


Ala Lys Ala Val Gly Trp Ala Gln Asp Pro Ala Asn Leu Thr Thr Asp 
    210                 215                 220                 


Asp Thr Gly Ser Tyr Trp Thr Asn Tyr Ser Pro Thr Asn Thr Ala Gly 
225                 230                 235                 240 


Met Met Leu Met Ala Ile Gly Asp Val Asn Asp Pro Lys Ile Asp Val 
                245                 250                 255     


Ser Lys Gln Met Asp Phe Leu Ile Gly Arg Gln Leu Pro Ser Gly Ala 
            260                 265                 270         


Phe Ser Asn Thr Leu Lys Gly Thr Asn Asp Asn Ala Met Ala Thr Thr 
        275                 280                 285             


Gln Ala Leu Gln Gly Leu Thr Met His Gly Tyr Leu Thr Ala Ser Ala 
    290                 295                 300                 


Gly Gln Lys Thr Asp Pro Gly Thr Gly Gly Gly Thr Thr Asp Pro Gly 
305                 310                 315                 320 


Thr Gly Gly Gly Thr Gly Gly Gly Ser Thr Gly Gly Gly Ser Thr Gly 
                325                 330                 335     


Gly Gly Gly Ser Thr Gly Gly Gly Gly Ser Thr Gly Gly Gly Gly Ser 
            340                 345                 350         


Thr Gly Gly Gly Gly Val Val Thr Pro Pro Val Thr Gln Ala Phe Thr 
        355                 360                 365             


Asp Val Ala Pro Ser Asn Met Tyr Phe Thr Glu Ile Gln Trp Ala Ala 
    370                 375                 380                 


Ala Asn Asn Val Thr Thr Gly Trp Lys Asn Ala Asp Gly Thr Ala Ser 
385                 390                 395                 400 


Phe Arg Pro Leu Asp Thr Thr His Arg Asp Ala Met Ala Ala Phe Leu 
                405                 410                 415     


Tyr Arg Leu Ser Gly Ser Pro Ser Tyr Thr Ala Pro Ala Thr Ser Pro 
            420                 425                 430         


Phe Thr Asp Val Asn Pro Ser Asn Gln Phe Tyr Lys Glu Ile Cys Trp 
        435                 440                 445             


Leu Ala Ser Gln Asn Ile Thr Thr Gly Trp Pro Asp Gly Ser Phe Arg 
    450                 455                 460                 


Pro Leu Asp Asn Val Asn Arg Asp Ala Met Ala Ala Phe Leu Tyr Arg 
465                 470                 475                 480 


Tyr Ser Gln Val Ser Gly Phe Gln Ala Pro Ala Ala Ser Pro Phe Ala 
                485                 490                 495     


Asp Val Thr Pro Gly Ser Gln Phe Tyr Thr Glu Met Ser Trp Leu Ser 
            500                 505                 510         


Ala Asn Gly Ile Ser Thr Gly Trp Pro Asp Gln Thr Phe Arg Pro Val 
        515                 520                 525             


Thr Pro Ile Ala Arg Asp Ala Met Ile Thr Phe Ile Tyr Arg Met Lys 
    530                 535                 540                 


His Ala Ser 
545         


