                         SEQUENCE LISTING

<110>  Kymab Limited
 
<120>  Antigen-binding molecules comprising unpaired variable domains produced in mammals

<130>  K00055-1 WO

<150>  GB1814529.2
<151>  2018-09-06

<160>  101   

<170>  PatentIn version 3.5

<210>  1
<211>  66
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Nucleic acid encoding Ck signal peptide

<400>  1
atggacatga gggtccccgc tcagctcctg gggctcctgc tgctctggct cccaggaact       60

gtggct                                                                  66


<210>  2
<211>  22
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Ck signal peptide

<400>  2

Met Asp Met Arg Val Pro Ala Gln Leu Leu Gly Leu Leu Leu Leu Trp 
1               5                   10                  15      


Leu Pro Gly Thr Val Ala 
            20          


<210>  3
<211>  311
<212>  DNA
<213>  HomoSapien

<400>  3
gcaccatctg tcttcatctt cccgccatct gatgagcagt tgaaatctgg aactgcctct       60

gttgtgtgcc tgctgaataa cttctatccc agagaggcca aagtacagtg gaaggtggat      120

aacgccctcc aatcgggtaa ctcccaggag agtgtcacag agcaggacag caaggacagc      180

acctacagcc tcagcagcac cctgacgctg agcaaagcag actacgagaa acacaaagtc      240

tacgcctgcg aagtcaccca tcagggcctg agctcgcccg tcacaaagag cttcaacagg      300

ggagagtgtt a                                                           311


<210>  4
<211>  103
<212>  PRT
<213>  HomoSapien

<400>  4

Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser 
1               5                   10                  15      


Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu 
            20                  25                  30          


Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser 
        35                  40                  45              


Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu 
    50                  55                  60                  


Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val 
65                  70                  75                  80  


Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys 
                85                  90                  95      


Ser Phe Asn Arg Gly Glu Cys 
            100             


<210>  5
<211>  377
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Nucleic acid encoding kvC fusion with signal peptide

<400>  5
atggacatga gggtccccgc tcagctcctg gggctcctgc tgctctggct cccaggaact       60

gtggctgcac catctgtctt catcttcccg ccatctgatg agcagttgaa atctggaact      120

gcctctgttg tgtgcctgct gaataacttc tatcccagag aggccaaagt acagtggaag      180

gtggataacg ccctccaatc gggtaactcc caggagagtg tcacagagca ggacagcaag      240

gacagcacct acagcctcag cagcaccctg acgctgagca aagcagacta cgagaaacac      300

aaagtctacg cctgcgaagt cacccatcag ggcctgagct cgcccgtcac aaagagcttc      360

aacaggggag agtgtta                                                     377


<210>  6
<211>  125
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  kvC fusion with signal peptide

<400>  6

Met Asp Met Arg Val Pro Ala Gln Leu Leu Gly Leu Leu Leu Leu Trp 
1               5                   10                  15      


Leu Pro Gly Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser 
            20                  25                  30          


Asp Glu Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn 
        35                  40                  45              


Asn Phe Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala 
    50                  55                  60                  


Leu Gln Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys 
65                  70                  75                  80  


Asp Ser Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp 
                85                  90                  95      


Tyr Glu Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu 
            100                 105                 110         


Ser Ser Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
        115                 120                 125 


<210>  7
<211>  323
<212>  DNA
<213>  HomoSapien

<400>  7
ggaactgtgg ctgcaccatc tgtcttcatc ttcccgccat ctgatgagca gttgaaatct       60

ggaactgcct ctgttgtgtg cctgctgaat aacttctatc ccagagaggc caaagtacag      120

tggaaggtgg ataacgccct ccaatcgggt aactcccagg agagtgtcac agagcaggac      180

agcaaggaca gcacctacag cctcagcagc accctgacgc tgagcaaagc agactacgag      240

aaacacaaag tctacgcctg cgaagtcacc catcagggcc tgagctcgcc cgtcacaaag      300

agcttcaaca ggggagagtg tta                                              323


<210>  8
<211>  107
<212>  PRT
<213>  HomoSapien

<400>  8

Gly Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu 
1               5                   10                  15      


Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe 
            20                  25                  30          


Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln 
        35                  40                  45              


Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser 
    50                  55                  60                  


Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu 
65                  70                  75                  80  


Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser 
                85                  90                  95      


Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
            100                 105         


<210>  9
<211>  351
<212>  DNA
<213>  HomoSapien

<400>  9
atggacatga gggtccccgc tcagctcctg gggctcctgc tgctctggct cccaggtgcc       60

aaatgtgaca tccagatgac ccagtctcct tccaccctgt ctgcatctgt aggagacaga      120

gtcaccatca cttgccgggc cagtcagagt attagtagct ggttggcctg gtatcagcag      180

aaaccaggga aagcccctaa gctcctgatc tataaggcgt ctagtttaga aagtggggtc      240

ccatcaaggt tcagcggcag tggatctggg acagaattca ctctcaccat cagcagcctg      300

cagcctgatg attttgcaac ttattactgc caacagtata atagttattc t               351


<210>  10
<211>  117
<212>  PRT
<213>  HomoSapien

<400>  10

Met Asp Met Arg Val Pro Ala Gln Leu Leu Gly Leu Leu Leu Leu Trp 
1               5                   10                  15      


Leu Pro Gly Ala Lys Cys Asp Ile Gln Met Thr Gln Ser Pro Ser Thr 
            20                  25                  30          


Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ala Ser 
        35                  40                  45              


Gln Ser Ile Ser Ser Trp Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys 
    50                  55                  60                  


Ala Pro Lys Leu Leu Ile Tyr Lys Ala Ser Ser Leu Glu Ser Gly Val 
65                  70                  75                  80  


Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr 
                85                  90                  95      


Ile Ser Ser Leu Gln Pro Asp Asp Phe Ala Thr Tyr Tyr Cys Gln Gln 
            100                 105                 110         


Tyr Asn Ser Tyr Ser 
        115         


<210>  11
<211>  66
<212>  DNA
<213>  HomoSapien

<400>  11
atggacatga gggtccccgc tcagctcctg gggctcctgc tgctctggct cccaggtgcc       60

aaatgt                                                                  66


<210>  12
<211>  22
<212>  PRT
<213>  HomoSapien

<400>  12

Met Asp Met Arg Val Pro Ala Gln Leu Leu Gly Leu Leu Leu Leu Trp 
1               5                   10                  15      


Leu Pro Gly Ala Lys Cys 
            20          


<210>  13
<211>  990
<212>  DNA
<213>  HomoSapien

<400>  13
gcctccacca agggcccatc ggtcttcccc ctggcaccct cctccaagag cacctctggg       60

ggcacagcgg ccctgggctg cctggtcaag gactacttcc ccgaaccggt gacggtgtcg      120

tggaactcag gcgccctgac cagcggcgtg cacaccttcc cggctgtcct acagtcctca      180

ggactctact ccctcagcag cgtggtgacc gtgccctcca gcagcttggg cacccagacc      240

tacatctgca acgtgaatca caagcccagc aacaccaagg tggacaagaa agttgagccc      300

aaatcttgtg acaaaactca cacatgccca ccgtgcccag cacctgaact cctgggggga      360

ccgtcagtct tcctcttccc cccaaaaccc aaggacaccc tcatgatctc ccggacccct      420

gaggtcacat gcgtggtggt ggacgtgagc cacgaagacc ctgaggtcaa gttcaactgg      480

tacgtggacg gcgtggaggt gcataatgcc aagacaaagc cgcgggagga gcagtacaac      540

agcacgtacc gggtggtcag cgtcctcacc gtcctgcacc aggactggct gaatggcaag      600

gagtacaagt gcaaggtctc caacaaagcc ctcccagccc ccatcgagaa aaccatctcc      660

aaagccaaag ggcagccccg agaaccacag gtgtacaccc tgcccccatc ccgggatgag      720

ctgaccaaga accaggtcag cctgacctgc ctggtcaaag gcttctatcc cagcgacatc      780

gccgtggagt gggagagcaa tgggcagccg gagaacaact acaagaccac gcctcccgtg      840

ctggactccg acggctcctt cttcctctac agcaagctca ccgtggacaa gagcaggtgg      900

cagcagggga acgtcttctc atgctccgtg atgcatgagg ctctgcacaa ccactacacg      960

cagaagagcc tctccctgtc tccgggtaaa                                       990


<210>  14
<211>  330
<212>  PRT
<213>  HomoSapien

<400>  14

Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys 
1               5                   10                  15      


Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
            20                  25                  30          


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        35                  40                  45              


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  


Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr 
65                  70                  75                  80  


Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys 
                85                  90                  95      


Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys 
            100                 105                 110         


Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro 
        115                 120                 125             


Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys 
    130                 135                 140                 


Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp 
145                 150                 155                 160 


Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu 
                165                 170                 175     


Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu 
            180                 185                 190         


His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn 
        195                 200                 205             


Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly 
    210                 215                 220                 


Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu 
225                 230                 235                 240 


Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr 
                245                 250                 255     


Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn 
            260                 265                 270         


Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe 
        275                 280                 285             


Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn 
    290                 295                 300                 


Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr 
305                 310                 315                 320 


Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
                325                 330 


<210>  15
<211>  990
<212>  DNA
<213>  HomoSapien

<400>  15
gcctccacca agggcccatc ggtcttcccc ctggcaccct cctccaagag cacctctggg       60

ggcacagcgg ccctgggctg cctggtcaag gactacttcc ccgaaccggt gacggtgtcg      120

tggaactcag gcgccctgac cagcggcgtg cacaccttcc cggctgtcct acagtcctca      180

ggactctact ccctcagcag cgtggtgacc gtgccctcca gcagcttggg cacccagacc      240

tacatctgca acgtgaatca caagcccagc aacaccaagg tggacaagaa agttgagccc      300

aaatcttgtg acaaaactca cacatgccca ccgtgcccag cacctgaact cctgggggga      360

ccgtcagtct tcctcttccc cccaaaaccc aaggacaccc tcatgatctc ccggacccct      420

gaggtcacat gcgtggtggt ggacgtgagc cacgaagacc ctgaggtcaa gttcaactgg      480

tacgtggacg gcgtggaggt gcataatgcc aagacaaagc cgcgggagga gcagtacaac      540

agcacgtacc gtgtggtcag cgtcctcacc gtcctgcacc aggactggct gaatggcaag      600

gagtacaagt gcaaggtctc caacaaagcc ctcccagccc ccatcgagaa aaccatctcc      660

aaagccaaag ggcagccccg agaaccacag gtgtacaccc tgcccccatc ccgggatgag      720

ctgaccaaga accaggtcag cctgacctgc ctggtcaaag gcttctatcc cagcgacatc      780

gccgtggagt gggagagcaa tgggcagccg gagaacaact acaagaccac gcctcccgtg      840

ctggactccg acggctcctt cttcctctac agcaagctca ccgtggacaa gagcaggtgg      900

cagcagggga acgtcttctc atgctccgtg atgcatgagg ctctgcacaa ccactacacg      960

cagaagagcc tctccctgtc tccgggtaaa                                       990


<210>  16
<211>  330
<212>  PRT
<213>  HomoSapien

<400>  16

Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys 
1               5                   10                  15      


Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
            20                  25                  30          


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        35                  40                  45              


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  


Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr 
65                  70                  75                  80  


Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys 
                85                  90                  95      


Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys 
            100                 105                 110         


Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro 
        115                 120                 125             


Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys 
    130                 135                 140                 


Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp 
145                 150                 155                 160 


Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu 
                165                 170                 175     


Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu 
            180                 185                 190         


His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn 
        195                 200                 205             


Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly 
    210                 215                 220                 


Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu 
225                 230                 235                 240 


Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr 
                245                 250                 255     


Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn 
            260                 265                 270         


Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe 
        275                 280                 285             


Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn 
    290                 295                 300                 


Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr 
305                 310                 315                 320 


Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
                325                 330 


<210>  17
<211>  990
<212>  DNA
<213>  HomoSapien

<400>  17
gcctccacca agggcccatc ggtcttcccc ctggcaccct cctccaagag cacctctggg       60

ggcacagcgg ccctgggctg cctggtcaag gactacttcc ccgaaccggt gacggtgtcg      120

tggaactcag gcgccctgac cagcggcgtg cacaccttcc cggctgtcct acagtcctca      180

ggactctact ccctcagcag cgtggtgacc gtgccctcca gcagcttggg cacccagacc      240

tacatctgca acgtgaatca caagcccagc aacaccaagg tggacaagag agttgagccc      300

aaatcttgtg acaaaactca cacatgccca ccgtgcccag cacctgaact cctgggggga      360

ccgtcagtct tcctcttccc cccaaaaccc aaggacaccc tcatgatctc ccggacccct      420

gaggtcacat gcgtggtggt ggacgtgagc cacgaagacc ctgaggtcaa gttcaactgg      480

tacgtggacg gcgtggaggt gcataatgcc aagacaaagc cgcgggagga gcagtacaac      540

agcacgtacc gtgtggtcag cgtcctcacc gtcctgcacc aggactggct gaatggcaag      600

gagtacaagt gcaaggtctc caacaaagcc ctcccagccc ccatcgagaa aaccatctcc      660

aaagccaaag ggcagccccg agaaccacag gtgtacaccc tgcccccatc ccgggaggag      720

atgaccaaga accaggtcag cctgacctgc ctggtcaaag gcttctatcc cagcgacatc      780

gccgtggagt gggagagcaa tgggcagccg gagaacaact acaagaccac gcctcccgtg      840

ctggactccg acggctcctt cttcctctat agcaagctca ccgtggacaa gagcaggtgg      900

cagcagggga acgtcttctc atgctccgtg atgcatgagg ctctgcacaa ccactacacg      960

cagaagagcc tctccctgtc cccgggtaaa                                       990


<210>  18
<211>  330
<212>  PRT
<213>  HomoSapien

<400>  18

Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys 
1               5                   10                  15      


Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
            20                  25                  30          


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        35                  40                  45              


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  


Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr 
65                  70                  75                  80  


Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys 
                85                  90                  95      


Arg Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys 
            100                 105                 110         


Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro 
        115                 120                 125             


Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys 
    130                 135                 140                 


Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp 
145                 150                 155                 160 


Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu 
                165                 170                 175     


Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu 
            180                 185                 190         


His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn 
        195                 200                 205             


Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly 
    210                 215                 220                 


Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu 
225                 230                 235                 240 


Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr 
                245                 250                 255     


Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn 
            260                 265                 270         


Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe 
        275                 280                 285             


Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn 
    290                 295                 300                 


Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr 
305                 310                 315                 320 


Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
                325                 330 


<210>  19
<211>  990
<212>  DNA
<213>  HomoSapien

<400>  19
gcctccacca agggcccatc ggtcttcccc ctggcaccct cctccaagag cacctctggg       60

ggcacagcgg ccctgggctg cctggtcaag gactacttcc ccgaaccggt gacggtgtcg      120

tggaactcag gcgccctgac cagcggcgtg cacaccttcc cggctgtcct acagtcctca      180

ggactctact ccctcagcag cgtggtgacc gtgccctcca gcagcttggg cacccagacc      240

tacatctgca acgtgaatca caagcccagc aacaccaagg tggacaagaa agttgagccc      300

aaatcttgtg acaaaactca cacatgccca ccgtgcccag cacctgaact cctgggggga      360

ccgtcagtct tcctcttccc cccaaaaccc aaggacaccc tcatgatctc ccggacccct      420

gaggtcacat gcgtggtggt ggacgtgagc cacgaagacc ctgaggtcaa gttcaactgg      480

tacgtggacg gcgtggaggt gcataatgcc aagacaaagc cgcgggagga gcagtacaac      540

agcacgtacc gtgtggtcag cgtcctcacc gtcctgcacc aggactggct gaatggcaag      600

gagtacaagt gcaaggtctc caacaaagcc ctcccagccc ccatcgagaa aaccatctcc      660

aaagccaaag ggcagccccg agaaccacag gtgtacaccc tgcccccatc ccgggatgag      720

ctgaccaaga accaggtcag cctgacctgc ctggtcaaag gcttctatcc cagcgacatc      780

gccgtggagt gggagagcaa tgggcagccg gagaacaact acaagaccac gcctcccgtg      840

ctggactccg acggctcctt cttcctctac agcaagctca ccgtggacaa gagcaggtgg      900

cagcagggga acatcttctc atgctccgtg atgcatgagg ctctgcacaa ccactacacg      960

cagaagagcc tctccctgtc tccgggtaaa                                       990


<210>  20
<211>  330
<212>  PRT
<213>  HomoSapien

<400>  20

Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys 
1               5                   10                  15      


Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
            20                  25                  30          


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        35                  40                  45              


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  


Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr 
65                  70                  75                  80  


Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys 
                85                  90                  95      


Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys 
            100                 105                 110         


Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro 
        115                 120                 125             


Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys 
    130                 135                 140                 


Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp 
145                 150                 155                 160 


Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu 
                165                 170                 175     


Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu 
            180                 185                 190         


His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn 
        195                 200                 205             


Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly 
    210                 215                 220                 


Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu 
225                 230                 235                 240 


Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr 
                245                 250                 255     


Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn 
            260                 265                 270         


Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe 
        275                 280                 285             


Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn 
    290                 295                 300                 


Ile Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr 
305                 310                 315                 320 


Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
                325                 330 


<210>  21
<211>  990
<212>  DNA
<213>  HomoSapien

<400>  21
gcctccacca agggcccatc ggtcttcccc ctggcaccct cctccaagag cacctctggg       60

ggcacagcgg ccctgggctg cctggtcaag gactacttcc ccgaaccggt gacggtgtcg      120

tggaactcag gcgccctgac cagcggcgtg cacaccttcc cggctgtcct acagtcctca      180

ggactctact ccctcagcag cgtggtgacc gtgccctcca gcagcttggg cacccagacc      240

tacatctgca acgtgaatca caagcccagc aacaccaagg tggacaagaa agtggagccc      300

aaatcttgtg acaaaactca cacatgccca ccgtgcccag cacctgaact cgcgggggca      360

ccgtcagtct tcctcttccc cccaaaaccc aaggacaccc tcatgatctc ccggacccct      420

gaggtcacat gcgtggtggt ggacgtgagc cacgaagacc ctgaggtcaa gttcaactgg      480

tacgtggacg gcgtggaggt gcataatgcc aagacaaagc cgcgggagga gcagtacaac      540

agcacgtacc gtgtggtcag cgtcctcacc gtcctgcacc aggactggct gaatggcaag      600

gagtacaagt gcaaggtctc caacaaagcc ctcccagccc ccatcgagaa aaccatctcc      660

aaagccaaag ggcagccccg agaaccacag gtgtacaccc tgcccccatc ccgggatgag      720

ctgaccaaga accaggtcag cctgacctgc ctggtcaaag gcttctatcc cagcgacatc      780

gccgtggagt gggagagcaa tgggcagccg gagaacaact acaagaccac gcctcccgtg      840

ctggactccg acggctcctt cttcctctac agcaagctca ccgtggacaa gagcaggtgg      900

cagcagggga acgtcttctc atgctccgtg atgcatgagg ctctgcacaa ccactacacg      960

cagaagagcc tctccctgtc tccgggtaaa                                       990


<210>  22
<211>  330
<212>  PRT
<213>  HomoSapien

<400>  22

Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys 
1               5                   10                  15      


Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
            20                  25                  30          


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        35                  40                  45              


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  


Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr 
65                  70                  75                  80  


Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys 
                85                  90                  95      


Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys 
            100                 105                 110         


Pro Ala Pro Glu Leu Ala Gly Ala Pro Ser Val Phe Leu Phe Pro Pro 
        115                 120                 125             


Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys 
    130                 135                 140                 


Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp 
145                 150                 155                 160 


Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu 
                165                 170                 175     


Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu 
            180                 185                 190         


His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn 
        195                 200                 205             


Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly 
    210                 215                 220                 


Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu 
225                 230                 235                 240 


Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr 
                245                 250                 255     


Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn 
            260                 265                 270         


Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe 
        275                 280                 285             


Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn 
    290                 295                 300                 


Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr 
305                 310                 315                 320 


Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
                325                 330 


<210>  23
<211>  978
<212>  DNA
<213>  HomoSapien

<400>  23
gcctccacca agggcccatc ggtcttcccc ctggcgccct gctccaggag cacctccgag       60

agcacagccg ccctgggctg cctggtcaag gactacttcc ccgaaccggt gacggtgtcg      120

tggaactcag gcgctctgac cagcggcgtg cacaccttcc cagctgtcct acagtcctca      180

ggactctact ccctcagcag cgtggtgacc gtgccctcca gcaacttcgg cacccagacc      240

tacacctgca acgtagatca caagcccagc aacaccaagg tggacaagac agttgagcgc      300

aaatgttgtg tcgagtgccc accgtgccca gcaccacctg tggcaggacc gtcagtcttc      360

ctcttccccc caaaacccaa ggacaccctc atgatctccc ggacccctga ggtcacgtgc      420

gtggtggtgg acgtgagcca cgaagacccc gaggtccagt tcaactggta cgtggacggc      480

gtggaggtgc ataatgccaa gacaaagcca cgggaggagc agttcaacag cacgttccgt      540

gtggtcagcg tcctcaccgt tgtgcaccag gactggctga acggcaagga gtacaagtgc      600

aaggtctcca acaaaggcct cccagccccc atcgagaaaa ccatctccaa aaccaaaggg      660

cagccccgag aaccacaggt gtacaccctg cccccatccc gggaggagat gaccaagaac      720

caggtcagcc tgacctgcct ggtcaaaggc ttctacccca gcgacatcgc cgtggagtgg      780

gagagcaatg ggcagccgga gaacaactac aagaccacac ctcccatgct ggactccgac      840

ggctccttct tcctctacag caagctcacc gtggacaaga gcaggtggca gcaggggaac      900

gtcttctcat gctccgtgat gcatgaggct ctgcacaacc actacacgca gaagagcctc      960

tccctgtctc cgggtaaa                                                    978


<210>  24
<211>  326
<212>  PRT
<213>  HomoSapien

<400>  24

Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Cys Ser Arg 
1               5                   10                  15      


Ser Thr Ser Glu Ser Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
            20                  25                  30          


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        35                  40                  45              


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  


Leu Ser Ser Val Val Thr Val Pro Ser Ser Asn Phe Gly Thr Gln Thr 
65                  70                  75                  80  


Tyr Thr Cys Asn Val Asp His Lys Pro Ser Asn Thr Lys Val Asp Lys 
                85                  90                  95      


Thr Val Glu Arg Lys Cys Cys Val Glu Cys Pro Pro Cys Pro Ala Pro 
            100                 105                 110         


Pro Val Ala Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp 
        115                 120                 125             


Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp 
    130                 135                 140                 


Val Ser His Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp Gly 
145                 150                 155                 160 


Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe Asn 
                165                 170                 175     


Ser Thr Phe Arg Val Val Ser Val Leu Thr Val Val His Gln Asp Trp 
            180                 185                 190         


Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu Pro 
        195                 200                 205             


Ala Pro Ile Glu Lys Thr Ile Ser Lys Thr Lys Gly Gln Pro Arg Glu 
    210                 215                 220                 


Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn 
225                 230                 235                 240 


Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile 
                245                 250                 255     


Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr 
            260                 265                 270         


Thr Pro Pro Met Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys 
        275                 280                 285             


Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys 
    290                 295                 300                 


Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu 
305                 310                 315                 320 


Ser Leu Ser Pro Gly Lys 
                325     


<210>  25
<211>  978
<212>  DNA
<213>  HomoSapien

<400>  25
gcctccacca agggcccatc ggtcttcccc ctggcgccct gctccaggag cacctccgag       60

agcacagcgg ccctgggctg cctggtcaag gactacttcc ccgaaccggt gacggtgtcg      120

tggaactcag gcgctctgac cagcggcgtg cacaccttcc cggctgtcct acagtcctca      180

ggactctact ccctcagcag cgtggtgacc gtgacctcca gcaacttcgg cacccagacc      240

tacacctgca acgtagatca caagcccagc aacaccaagg tggacaagac agttgagcgc      300

aaatgttgtg tcgagtgccc accgtgccca gcaccacctg tggcaggacc gtcagtcttc      360

ctcttccccc caaaacccaa ggacaccctc atgatctccc ggacccctga ggtcacgtgc      420

gtggtggtgg acgtgagcca cgaagacccc gaggtccagt tcaactggta cgtggacggc      480

atggaggtgc ataatgccaa gacaaagcca cgggaggagc agttcaacag cacgttccgt      540

gtggtcagcg tcctcaccgt cgtgcaccag gactggctga acggcaagga gtacaagtgc      600

aaggtctcca acaaaggcct cccagccccc atcgagaaaa ccatctccaa aaccaaaggg      660

cagccccgag aaccacaggt gtacaccctg cccccatccc gggaggagat gaccaagaac      720

caggtcagcc tgacctgcct ggtcaaaggc ttctacccca gcgacatcgc cgtggagtgg      780

gagagcaatg ggcagccgga gaacaactac aagaccacac ctcccatgct ggactccgac      840

ggctccttct tcctctacag caagctcacc gtggacaaga gcaggtggca gcaggggaac      900

gtcttctcat gctccgtgat gcatgaggct ctgcacaacc actacacaca gaagagcctc      960

tccctgtctc cgggtaaa                                                    978


<210>  26
<211>  326
<212>  PRT
<213>  HomoSapien

<400>  26

Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Cys Ser Arg 
1               5                   10                  15      


Ser Thr Ser Glu Ser Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
            20                  25                  30          


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        35                  40                  45              


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  


Leu Ser Ser Val Val Thr Val Thr Ser Ser Asn Phe Gly Thr Gln Thr 
65                  70                  75                  80  


Tyr Thr Cys Asn Val Asp His Lys Pro Ser Asn Thr Lys Val Asp Lys 
                85                  90                  95      


Thr Val Glu Arg Lys Cys Cys Val Glu Cys Pro Pro Cys Pro Ala Pro 
            100                 105                 110         


Pro Val Ala Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp 
        115                 120                 125             


Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp 
    130                 135                 140                 


Val Ser His Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp Gly 
145                 150                 155                 160 


Met Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe Asn 
                165                 170                 175     


Ser Thr Phe Arg Val Val Ser Val Leu Thr Val Val His Gln Asp Trp 
            180                 185                 190         


Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu Pro 
        195                 200                 205             


Ala Pro Ile Glu Lys Thr Ile Ser Lys Thr Lys Gly Gln Pro Arg Glu 
    210                 215                 220                 


Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn 
225                 230                 235                 240 


Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile 
                245                 250                 255     


Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr 
            260                 265                 270         


Thr Pro Pro Met Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys 
        275                 280                 285             


Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys 
    290                 295                 300                 


Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu 
305                 310                 315                 320 


Ser Leu Ser Pro Gly Lys 
                325     


<210>  27
<211>  978
<212>  DNA
<213>  HomoSapien

<400>  27
gcctccacca agggcccatc ggtcttcccc ctggcgccct gctccaggag cacctccgag       60

agcacagcgg ccctgggctg cctggtcaag gactacttcc ccgaaccggt gacggtgtcg      120

tggaactcag gcgctctgac cagcggcgtg cacaccttcc cagctgtcct acagtcctca      180

ggactctact ccctcagcag cgtggtgacc gtgccctcca gcagcttggg cacccagacc      240

tacacctgca acgtagatca caagcccagc aacaccaagg tggacaagac agttgagcgc      300

aaatgttgtg tcgagtgccc accgtgccca gcaccacctg tggcaggacc gtcagtcttc      360

ctcttccccc caaaacccaa ggacaccctc atgatctccc ggacccctga ggtcacgtgc      420

gtggtggtgg acgtgagcca cgaagacccc gaggtccagt tcaactggta cgtggacggc      480

gtggaggtgc ataatgccaa gacaaagcca cgggaggagc agttcaacag cacgttccgt      540

gtggtcagcg tcctcaccgt tgtgcaccag gactggctga acggcaagga gtacaagtgc      600

aaggtctcca acaaaggcct cccagccccc atcgagaaaa ccatctccaa aaccaaaggg      660

cagccccgag aaccacaggt gtacaccctg cccccatccc gggaggagat gaccaagaac      720

caggtcagcc tgacctgcct ggtcaaaggc ttctacccca gcgacatcgc cgtggagtgg      780

gagagcaatg ggcagccgga gaacaactac aagaccacac ctcccatgct ggactccgac      840

ggctccttct tcctctacag caagctcacc gtggacaaga gcaggtggca gcaggggaac      900

gtcttctcat gctccgtgat gcatgaggct ctgcacaacc actacacgca gaagagcctc      960

tccctgtctc cgggtaaa                                                    978


<210>  28
<211>  326
<212>  PRT
<213>  HomoSapien

<400>  28

Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Cys Ser Arg 
1               5                   10                  15      


Ser Thr Ser Glu Ser Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
            20                  25                  30          


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        35                  40                  45              


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  


Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr 
65                  70                  75                  80  


Tyr Thr Cys Asn Val Asp His Lys Pro Ser Asn Thr Lys Val Asp Lys 
                85                  90                  95      


Thr Val Glu Arg Lys Cys Cys Val Glu Cys Pro Pro Cys Pro Ala Pro 
            100                 105                 110         


Pro Val Ala Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp 
        115                 120                 125             


Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp 
    130                 135                 140                 


Val Ser His Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp Gly 
145                 150                 155                 160 


Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe Asn 
                165                 170                 175     


Ser Thr Phe Arg Val Val Ser Val Leu Thr Val Val His Gln Asp Trp 
            180                 185                 190         


Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu Pro 
        195                 200                 205             


Ala Pro Ile Glu Lys Thr Ile Ser Lys Thr Lys Gly Gln Pro Arg Glu 
    210                 215                 220                 


Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn 
225                 230                 235                 240 


Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile 
                245                 250                 255     


Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr 
            260                 265                 270         


Thr Pro Pro Met Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys 
        275                 280                 285             


Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys 
    290                 295                 300                 


Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu 
305                 310                 315                 320 


Ser Leu Ser Pro Gly Lys 
                325     


<210>  29
<211>  978
<212>  DNA
<213>  HomoSapien

<400>  29
gcctccacca agggcccatc ggtcttcccc ctggcgccct gctccaggag cacctccgag       60

agcacagcgg ccctgggctg cctggtcaag gactacttcc ccgaaccggt gacggtgtcg      120

tggaactcag gcgctctgac cagcggcgtg cacaccttcc cggctgtcct acagtcctca      180

ggactctact ccctcagcag cgtggtgacc gtgccctcca gcaacttcgg cacccagacc      240

tacacctgca acgtagatca caagcccagc aacaccaagg tggacaagac agttgagcgc      300

aaatgttgtg tcgagtgccc accgtgccca gcaccacctg tggcaggacc gtcagtcttc      360

ctcttccccc caaaacccaa ggacaccctc atgatctccc ggacccctga ggtcacgtgc      420

gtggtggtgg acgtgagcca cgaagacccc gaggtccagt tcaactggta cgtggacggc      480

gtggaggtgc ataatgccaa gacaaagcca cgggaggagc agttcaacag cacgttccgt      540

gtggtcagcg tcctcaccgt cgtgcaccag gactggctga acggcaagga gtacaagtgc      600

aaggtctcca acaaaggcct cccagccccc atcgagaaaa ccatctccaa aaccaaaggg      660

cagccccgag aaccacaggt gtacaccctg cccccatccc gggaggagat gaccaagaac      720

caggtcagcc tgacctgcct ggtcaaaggc ttctacccca gcgacatctc cgtggagtgg      780

gagagcaatg ggcagccgga gaacaactac aagaccacac ctcccatgct ggactccgac      840

ggctccttct tcctctacag caagctcacc gtggacaaga gcaggtggca gcaggggaac      900

gtcttctcat gctccgtgat gcatgaggct ctgcacaacc actacacaca gaagagcctc      960

tccctgtctc cgggtaaa                                                    978


<210>  30
<211>  326
<212>  PRT
<213>  HomoSapien

<400>  30

Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Cys Ser Arg 
1               5                   10                  15      


Ser Thr Ser Glu Ser Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
            20                  25                  30          


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        35                  40                  45              


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  


Leu Ser Ser Val Val Thr Val Pro Ser Ser Asn Phe Gly Thr Gln Thr 
65                  70                  75                  80  


Tyr Thr Cys Asn Val Asp His Lys Pro Ser Asn Thr Lys Val Asp Lys 
                85                  90                  95      


Thr Val Glu Arg Lys Cys Cys Val Glu Cys Pro Pro Cys Pro Ala Pro 
            100                 105                 110         


Pro Val Ala Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp 
        115                 120                 125             


Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp 
    130                 135                 140                 


Val Ser His Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp Gly 
145                 150                 155                 160 


Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe Asn 
                165                 170                 175     


Ser Thr Phe Arg Val Val Ser Val Leu Thr Val Val His Gln Asp Trp 
            180                 185                 190         


Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu Pro 
        195                 200                 205             


Ala Pro Ile Glu Lys Thr Ile Ser Lys Thr Lys Gly Gln Pro Arg Glu 
    210                 215                 220                 


Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn 
225                 230                 235                 240 


Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile 
                245                 250                 255     


Ser Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr 
            260                 265                 270         


Thr Pro Pro Met Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys 
        275                 280                 285             


Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys 
    290                 295                 300                 


Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu 
305                 310                 315                 320 


Ser Leu Ser Pro Gly Lys 
                325     


<210>  31
<211>  981
<212>  DNA
<213>  HomoSapien

<400>  31
gcttccacca agggcccatc cgtcttcccc ctggcgccct gctccaggag cacctccgag       60

agcacagccg ccctgggctg cctggtcaag gactacttcc ccgaaccggt gacggtgtcg      120

tggaactcag gcgccctgac cagcggcgtg cacaccttcc cggctgtcct acagtcctca      180

ggactctact ccctcagcag cgtggtgacc gtgccctcca gcagcttggg cacgaagacc      240

tacacctgca acgtagatca caagcccagc aacaccaagg tggacaagag agttgagtcc      300

aaatatggtc ccccatgccc atcatgccca gcacctgagt tcctgggggg accatcagtc      360

ttcctgttcc ccccaaaacc caaggacact ctcatgatct cccggacccc tgaggtcacg      420

tgcgtggtgg tggacgtgag ccaggaagac cccgaggtcc agttcaactg gtacgtggat      480

ggcgtggagg tgcataatgc caagacaaag ccgcgggagg agcagttcaa cagcacgtac      540

cgtgtggtca gcgtcctcac cgtcctgcac caggactggc tgaacggcaa ggagtacaag      600

tgcaaggtct ccaacaaagg cctcccgtcc tccatcgaga aaaccatctc caaagccaaa      660

gggcagcccc gagagccaca ggtgtacacc ctgcccccat cccaggagga gatgaccaag      720

aaccaggtca gcctgacctg cctggtcaaa ggcttctacc ccagcgacat cgccgtggag      780

tgggagagca atgggcagcc ggagaacaac tacaagacca cgcctcccgt gctggactcc      840

gacggctcct tcttcctcta cagcaggcta accgtggaca agagcaggtg gcaggagggg      900

aatgtcttct catgctccgt gatgcatgag gctctgcaca accactacac acagaagagc      960

ctctccctgt ctctgggtaa a                                                981


<210>  32
<211>  327
<212>  PRT
<213>  HomoSapien

<400>  32

Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Cys Ser Arg 
1               5                   10                  15      


Ser Thr Ser Glu Ser Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
            20                  25                  30          


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        35                  40                  45              


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  


Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Lys Thr 
65                  70                  75                  80  


Tyr Thr Cys Asn Val Asp His Lys Pro Ser Asn Thr Lys Val Asp Lys 
                85                  90                  95      


Arg Val Glu Ser Lys Tyr Gly Pro Pro Cys Pro Ser Cys Pro Ala Pro 
            100                 105                 110         


Glu Phe Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys 
        115                 120                 125             


Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val 
    130                 135                 140                 


Asp Val Ser Gln Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp 
145                 150                 155                 160 


Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe 
                165                 170                 175     


Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp 
            180                 185                 190         


Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu 
        195                 200                 205             


Pro Ser Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg 
    210                 215                 220                 


Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Gln Glu Glu Met Thr Lys 
225                 230                 235                 240 


Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp 
                245                 250                 255     


Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys 
            260                 265                 270         


Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser 
        275                 280                 285             


Arg Leu Thr Val Asp Lys Ser Arg Trp Gln Glu Gly Asn Val Phe Ser 
    290                 295                 300                 


Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser 
305                 310                 315                 320 


Leu Ser Leu Ser Leu Gly Lys 
                325         


<210>  33
<211>  981
<212>  DNA
<213>  HomoSapien

<400>  33
gcttccacca agggcccatc cgtcttcccc ctggcgccct gctccaggag cacctccgag       60

agcacagccg ccctgggctg cctggtcaag gactacttcc ccgaaccggt gacggtgtcg      120

tggaactcag gcgccctgac cagcggcgtg cacaccttcc cggctgtcct acagtcctca      180

ggactctact ccctcagcag cgtggtgacc gtgccctcca gcagcttggg cacgaagacc      240

tacacctgca acgtagatca caagcccagc aacaccaagg tggacaagag agttgagtcc      300

aaatatggtc ccccgtgccc atcatgccca gcacctgagt tcctgggggg accatcagtc      360

ttcctgttcc ccccaaaacc caaggacact ctcatgatct cccggacccc tgaggtcacg      420

tgcgtggtgg tggacgtgag ccaggaagac cccgaggtcc agttcaactg gtacgtggat      480

ggcgtggagg tgcataatgc caagacaaag ccgcgggagg agcagttcaa cagcacgtac      540

cgtgtggtca gcgtcctcac cgtcgtgcac caggactggc tgaacggcaa ggagtacaag      600

tgcaaggtct ccaacaaagg cctcccgtcc tccatcgaga aaaccatctc caaagccaaa      660

gggcagcccc gagagccaca ggtgtacacc ctgcccccat cccaggagga gatgaccaag      720

aaccaggtca gcctgacctg cctggtcaaa ggcttctacc ccagcgacat cgccgtggag      780

tgggagagca atgggcagcc ggagaacaac tacaagacca cgcctcccgt gctggactcc      840

gacggctcct tcttcctcta cagcaggcta accgtggaca agagcaggtg gcaggagggg      900

aatgtcttct catgctccgt gatgcatgag gctctgcaca accactacac gcagaagagc      960

ctctccctgt ctctgggtaa a                                                981


<210>  34
<211>  327
<212>  PRT
<213>  HomoSapien

<400>  34

Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Cys Ser Arg 
1               5                   10                  15      


Ser Thr Ser Glu Ser Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
            20                  25                  30          


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        35                  40                  45              


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  


Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Lys Thr 
65                  70                  75                  80  


Tyr Thr Cys Asn Val Asp His Lys Pro Ser Asn Thr Lys Val Asp Lys 
                85                  90                  95      


Arg Val Glu Ser Lys Tyr Gly Pro Pro Cys Pro Ser Cys Pro Ala Pro 
            100                 105                 110         


Glu Phe Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys 
        115                 120                 125             


Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val 
    130                 135                 140                 


Asp Val Ser Gln Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp 
145                 150                 155                 160 


Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe 
                165                 170                 175     


Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Val His Gln Asp 
            180                 185                 190         


Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu 
        195                 200                 205             


Pro Ser Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg 
    210                 215                 220                 


Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Gln Glu Glu Met Thr Lys 
225                 230                 235                 240 


Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp 
                245                 250                 255     


Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys 
            260                 265                 270         


Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser 
        275                 280                 285             


Arg Leu Thr Val Asp Lys Ser Arg Trp Gln Glu Gly Asn Val Phe Ser 
    290                 295                 300                 


Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser 
305                 310                 315                 320 


Leu Ser Leu Ser Leu Gly Lys 
                325         


<210>  35
<211>  981
<212>  DNA
<213>  HomoSapien

<400>  35
gcttccacca agggcccatc cgtcttcccc ctggcgccct gctccaggag cacctccgag       60

agcacagccg ccctgggctg cctggtcaag gactacttcc ccgaaccggt gacggtgtcg      120

tggaactcag gcgccctgac cagcggcgtg cacaccttcc cggctgtcct acagtcctca      180

ggactctact ccctcagcag cgtggtgacc gtgccctcca gcagcttggg cacgaagacc      240

tacacctgca acgtagatca caagcccagc aacaccaagg tggacaagag agttgagtcc      300

aaatatggtc ccccatgccc atcatgccca gcacctgagt tcctgggggg accatcagtc      360

ttcctgttcc ccccaaaacc caaggacact ctcatgatct cccggacccc tgaggtcacg      420

tgcgtggtgg tggacgtgag ccaggaagac cccgaggtcc agttcaactg gtacgtggat      480

ggcgtggagg tgcataatgc caagacaaag ccgcgggagg agcagttcaa cagcacgtac      540

cgtgtggtca gcgtcctcac cgtcctgcac caggactggc tgaacggcaa ggagtacaag      600

tgcaaggtct ccaacaaagg cctcccgtcc tccatcgaga aaaccatctc caaagccaaa      660

gggcagcccc gagagccaca ggtgtacacc ctgcccccat cccaggagga gatgaccaag      720

aaccaggtca gcctgacctg cctggtcaaa ggcttctacc ccagcgacat cgccgtggag      780

tgggagagca atgggcagcc ggagaacaac tacaagacca cgcctcccgt gctggactcc      840

gacggctcct tcttcctcta cagcaagctc accgtggaca agagcaggtg gcaggagggg      900

aacgtcttct catgctccgt gatgcatgag gctctgcaca accactacac gcagaagagc      960

ctctccctgt ctctgggtaa a                                                981


<210>  36
<211>  327
<212>  PRT
<213>  HomoSapien

<400>  36

Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Cys Ser Arg 
1               5                   10                  15      


Ser Thr Ser Glu Ser Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
            20                  25                  30          


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        35                  40                  45              


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  


Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Lys Thr 
65                  70                  75                  80  


Tyr Thr Cys Asn Val Asp His Lys Pro Ser Asn Thr Lys Val Asp Lys 
                85                  90                  95      


Arg Val Glu Ser Lys Tyr Gly Pro Pro Cys Pro Ser Cys Pro Ala Pro 
            100                 105                 110         


Glu Phe Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys 
        115                 120                 125             


Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val 
    130                 135                 140                 


Asp Val Ser Gln Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp 
145                 150                 155                 160 


Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe 
                165                 170                 175     


Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp 
            180                 185                 190         


Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu 
        195                 200                 205             


Pro Ser Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg 
    210                 215                 220                 


Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Gln Glu Glu Met Thr Lys 
225                 230                 235                 240 


Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp 
                245                 250                 255     


Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys 
            260                 265                 270         


Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser 
        275                 280                 285             


Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Glu Gly Asn Val Phe Ser 
    290                 295                 300                 


Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser 
305                 310                 315                 320 


Leu Ser Leu Ser Leu Gly Lys 
                325         


<210>  37
<211>  981
<212>  DNA
<213>  HomoSapien

<400>  37
gcctccacca agggcccatc cgtcttcccc ctggcgccct gctccaggag cacctccgag       60

agcacggccg ccctgggctg cctggtcaag gactacttcc ccgaaccagt gacggtgtcg      120

tggaactcag gcgccctgac cagcggcgtg cacaccttcc cggctgtcct acagtcctca      180

ggactctact ccctcagcag cgtggtgacc gtgccctcca gcagcttggg cacgaagacc      240

tacacctgca acgtagatca caagcccagc aacaccaagg tggacaagag agttgagtcc      300

aaatatggtc ccccatgccc accatgccca gcgcctgaat ttgagggggg accatcagtc      360

ttcctgttcc ccccaaaacc caaggacact ctcatgatct cccggacccc tgaggtcacg      420

tgcgtggtgg tggacgtgag ccaggaagac cccgaggtcc agttcaactg gtacgtggat      480

ggcgtggagg tgcataatgc caagacaaag ccgcgggagg agcagttcaa cagcacgtac      540

cgtgtggtca gcgtcctcac cgtcctgcac caggactggc tgaacggcaa ggagtacaag      600

tgcaaggtct ccaacaaagg cctcccgtca tcgatcgaga aaaccatctc caaagccaaa      660

gggcagcccc gagagccaca ggtgtacacc ctgcccccat cccaggagga gatgaccaag      720

aaccaggtca gcctgacctg cctggtcaaa ggcttctacc ccagcgacat cgccgtggag      780

tgggagagca atgggcagcc ggagaacaac tacaagacca cgcctcccgt gctggactcc      840

gacggatcct tcttcctcta cagcaggcta accgtggaca agagcaggtg gcaggagggg      900

aatgtcttct catgctccgt gatgcatgag gctctgcaca accactacac acagaagagc      960

ctctccctgt ctctgggtaa a                                                981


<210>  38
<211>  981
<212>  DNA
<213>  HomoSapien

<400>  38
gcctccacca agggacctag cgtgttccct ctcgccccct gttccaggtc cacaagcgag       60

tccaccgctg ccctcggctg tctggtgaaa gactactttc ccgagcccgt gaccgtctcc      120

tggaatagcg gagccctgac ctccggcgtg cacacatttc ccgccgtgct gcagagcagc      180

ggactgtata gcctgagcag cgtggtgacc gtgcccagct ccagcctcgg caccaaaacc      240

tacacctgca acgtggacca caagccctcc aacaccaagg tggacaagcg ggtggagagc      300

aagtacggcc ccccttgccc tccttgtcct gcccctgagt tcgagggagg accctccgtg      360

ttcctgtttc cccccaaacc caaggacacc ctgatgatct cccggacacc cgaggtgacc      420

tgtgtggtcg tggacgtcag ccaggaggac cccgaggtgc agttcaactg gtatgtggac      480

ggcgtggagg tgcacaatgc caaaaccaag cccagggagg agcagttcaa ttccacctac      540

agggtggtga gcgtgctgac cgtcctgcat caggattggc tgaacggcaa ggagtacaag      600

tgcaaggtgt ccaacaaggg actgcccagc tccatcgaga agaccatcag caaggctaag      660

ggccagccga gggagcccca ggtgtatacc ctgcctccta gccaggaaga gatgaccaag      720

aaccaagtgt ccctgacctg cctggtgaag ggattctacc cctccgacat cgccgtggag      780

tgggagagca atggccagcc cgagaacaac tacaaaacaa cccctcccgt gctcgatagc      840

gacggcagct tctttctcta cagccggctg acagtggaca agagcaggtg gcaggagggc      900

aacgtgttct cctgttccgt gatgcacgag gccctgcaca atcactacac ccagaagagc      960

ctctccctgt ccctgggcaa g                                                981


<210>  39
<211>  981
<212>  DNA
<213>  HomoSapien

<400>  39
gccagcacca agggcccttc cgtgttcccc ctggcccctt gcagcaggag cacctccgaa       60

tccacagctg ccctgggctg tctggtgaag gactactttc ccgagcccgt gaccgtgagc      120

tggaacagcg gcgctctgac atccggcgtc cacacctttc ctgccgtcct gcagtcctcc      180

ggcctctact ccctgtcctc cgtggtgacc gtgcctagct cctccctcgg caccaagacc      240

tacacctgta acgtggacca caaaccctcc aacaccaagg tggacaaacg ggtcgagagc      300

aagtacggcc ctccctgccc tccttgtcct gcccccgagt tcgaaggcgg acccagcgtg      360

ttcctgttcc ctcctaagcc caaggacacc ctcatgatca gccggacacc cgaggtgacc      420

tgcgtggtgg tggatgtgag ccaggaggac cctgaggtcc agttcaactg gtatgtggat      480

ggcgtggagg tgcacaacgc caagacaaag ccccgggaag agcagttcaa ctccacctac      540

agggtggtca gcgtgctgac cgtgctgcat caggactggc tgaacggcaa ggagtacaag      600

tgcaaggtca gcaataaggg actgcccagc agcatcgaga agaccatctc caaggctaaa      660

ggccagcccc gggaacctca ggtgtacacc ctgcctccca gccaggagga gatgaccaag      720

aaccaggtga gcctgacctg cctggtgaag ggattctacc cttccgacat cgccgtggag      780

tgggagtcca acggccagcc cgagaacaat tataagacca cccctcccgt cctcgacagc      840

gacggatcct tctttctgta ctccaggctg accgtggata agtccaggtg gcaggaaggc      900

aacgtgttca gctgctccgt gatgcacgag gccctgcaca atcactacac ccagaagtcc      960

ctgagcctgt ccctgggaaa g                                                981


<210>  40
<211>  327
<212>  PRT
<213>  HomoSapien

<400>  40

Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Cys Ser Arg 
1               5                   10                  15      


Ser Thr Ser Glu Ser Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
            20                  25                  30          


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        35                  40                  45              


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  


Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Lys Thr 
65                  70                  75                  80  


Tyr Thr Cys Asn Val Asp His Lys Pro Ser Asn Thr Lys Val Asp Lys 
                85                  90                  95      


Arg Val Glu Ser Lys Tyr Gly Pro Pro Cys Pro Pro Cys Pro Ala Pro 
            100                 105                 110         


Glu Phe Glu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys 
        115                 120                 125             


Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val 
    130                 135                 140                 


Asp Val Ser Gln Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp 
145                 150                 155                 160 


Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe 
                165                 170                 175     


Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp 
            180                 185                 190         


Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu 
        195                 200                 205             


Pro Ser Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg 
    210                 215                 220                 


Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Gln Glu Glu Met Thr Lys 
225                 230                 235                 240 


Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp 
                245                 250                 255     


Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys 
            260                 265                 270         


Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser 
        275                 280                 285             


Arg Leu Thr Val Asp Lys Ser Arg Trp Gln Glu Gly Asn Val Phe Ser 
    290                 295                 300                 


Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser 
305                 310                 315                 320 


Leu Ser Leu Ser Leu Gly Lys 
                325         


<210>  41
<211>  981
<212>  DNA
<213>  HomoSapien

<400>  41
gcctccacca agggcccatc cgtcttcccc ctggcgccct gctccaggag cacctccgag       60

agcacggccg ccctgggctg cctggtcaag gactacttcc ccgaaccagt gacggtgtcg      120

tggaactcag gcgccctgac cagcggcgtg cacaccttcc cggctgtcct acagtcctca      180

ggactctact ccctcagcag cgtggtgacc gtgccctcca gcagcttggg cacgaagacc      240

tacacctgca acgtagatca caagcccagc aacaccaagg tggacaagag agttgagtcc      300

aaatatggtc ccccatgccc accatgccca gcgcctccag ttgcgggggg accatcagtc      360

ttcctgttcc ccccaaaacc caaggacact ctcatgatct cccggacccc tgaggtcacg      420

tgcgtggtgg tggacgtgag ccaggaagac cccgaggtcc agttcaactg gtacgtggat      480

ggcgtggagg tgcataatgc caagacaaag ccgcgggagg agcagttcaa cagcacgtac      540

cgtgtggtca gcgtcctcac cgtcctgcac caggactggc tgaacggcaa ggagtacaag      600

tgcaaggtct ccaacaaagg cctcccgtca tcgatcgaga aaaccatctc caaagccaaa      660

gggcagcccc gagagccaca ggtgtacacc ctgcccccat cccaggagga gatgaccaag      720

aaccaggtca gcctgacctg cctggtcaaa ggcttctacc ccagcgacat cgccgtggag      780

tgggagagca atgggcagcc ggagaacaac tacaagacca cgcctcccgt gctggactcc      840

gacggatcct tcttcctcta cagcaggcta accgtggaca agagcaggtg gcaggagggg      900

aatgtcttct catgctccgt gatgcatgag gctctgcaca accactacac acagaagagc      960

ctctccctgt ctctgggtaa a                                                981


<210>  42
<211>  327
<212>  PRT
<213>  HomoSapien

<400>  42

Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Cys Ser Arg 
1               5                   10                  15      


Ser Thr Ser Glu Ser Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
            20                  25                  30          


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        35                  40                  45              


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  


Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Lys Thr 
65                  70                  75                  80  


Tyr Thr Cys Asn Val Asp His Lys Pro Ser Asn Thr Lys Val Asp Lys 
                85                  90                  95      


Arg Val Glu Ser Lys Tyr Gly Pro Pro Cys Pro Pro Cys Pro Ala Pro 
            100                 105                 110         


Pro Val Ala Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys 
        115                 120                 125             


Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val 
    130                 135                 140                 


Asp Val Ser Gln Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp 
145                 150                 155                 160 


Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe 
                165                 170                 175     


Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp 
            180                 185                 190         


Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu 
        195                 200                 205             


Pro Ser Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg 
    210                 215                 220                 


Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Gln Glu Glu Met Thr Lys 
225                 230                 235                 240 


Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp 
                245                 250                 255     


Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys 
            260                 265                 270         


Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser 
        275                 280                 285             


Arg Leu Thr Val Asp Lys Ser Arg Trp Gln Glu Gly Asn Val Phe Ser 
    290                 295                 300                 


Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser 
305                 310                 315                 320 


Leu Ser Leu Ser Leu Gly Lys 
                325         


<210>  43
<211>  321
<212>  DNA
<213>  HomoSapien

<400>  43
cgtacggtgg ccgctccctc cgtgttcatc ttcccacctt ccgacgagca gctgaagtcc       60

ggcaccgctt ctgtcgtgtg cctgctgaac aacttctacc cccgcgaggc caaggtgcag      120

tggaaggtgg acaacgccct gcagtccggc aactcccagg aatccgtgac cgagcaggac      180

tccaaggaca gcacctactc cctgtcctcc accctgaccc tgtccaaggc cgactacgag      240

aagcacaagg tgtacgcctg cgaagtgacc caccagggcc tgtctagccc cgtgaccaag      300

tctttcaacc ggggcgagtg t                                                321


<210>  44
<211>  107
<212>  PRT
<213>  HomoSapien

<400>  44

Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu 
1               5                   10                  15      


Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe 
            20                  25                  30          


Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln 
        35                  40                  45              


Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser 
    50                  55                  60                  


Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu 
65                  70                  75                  80  


Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser 
                85                  90                  95      


Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
            100                 105         


<210>  45
<211>  321
<212>  DNA
<213>  HomoSapien

<400>  45
cgaactgtgg ctgcaccatc tgtcttcatc ttcccgccat ctgatgagca gttgaaatct       60

ggaactgcct ctgttgtgtg cctgctgaat aacttctatc ccagagaggc caaagtacag      120

tggaaggtgg ataacgccct ccaatcgggt aactcccagg agagtgtcac agagcaggag      180

agcaaggaca gcacctacag cctcagcagc accctgacgc tgagcaaagc agactacgag      240

aaacacaaag tctacgccgg cgaagtcacc catcagggcc tgagctcgcc cgtcacaaag      300

agcttcaaca ggggagagtg t                                                321


<210>  46
<211>  107
<212>  PRT
<213>  HomoSapien

<400>  46

Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu 
1               5                   10                  15      


Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe 
            20                  25                  30          


Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln 
        35                  40                  45              


Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Glu Ser Lys Asp Ser 
    50                  55                  60                  


Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu 
65                  70                  75                  80  


Lys His Lys Val Tyr Ala Gly Glu Val Thr His Gln Gly Leu Ser Ser 
                85                  90                  95      


Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
            100                 105         


<210>  47
<211>  321
<212>  DNA
<213>  HomoSapien

<400>  47
cgaactgtgg ctgcaccatc tgtcttcatc ttcccgccat ctgatgagca gttgaaatct       60

ggaactgcct ctgttgtgtg cctgctgaat aacttctatc ccagagaggc caaagtacag      120

cggaaggtgg ataacgccct ccaatcgggt aactcccagg agagtgtcac agagcaggag      180

agcaaggaca gcacctacag cctcagcagc accctgacgc tgagcaaagc agactacgag      240

aaacacaaag tctacgcctg cgaagtcacc catcagggcc tgagctcgcc cgtcacaaag      300

agcttcaaca ggggagagtg t                                                321


<210>  48
<211>  107
<212>  PRT
<213>  HomoSapien

<400>  48

Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu 
1               5                   10                  15      


Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe 
            20                  25                  30          


Tyr Pro Arg Glu Ala Lys Val Gln Arg Lys Val Asp Asn Ala Leu Gln 
        35                  40                  45              


Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Glu Ser Lys Asp Ser 
    50                  55                  60                  


Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu 
65                  70                  75                  80  


Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser 
                85                  90                  95      


Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
            100                 105         


<210>  49
<211>  321
<212>  DNA
<213>  HomoSapien

<400>  49
cgaactgtgg ctgcaccatc tgtcttcatc ttcccgccat ctgatgagca gttgaaatct       60

ggaactgcct ctgttgtgtg cctgctgaat aacttctatc ccagagaggc caaagtacag      120

tggaaggtgg ataacgccct ccaatcgggt aactcccagg agagtgtcac agagcaggac      180

agcaaggaca gcacctacag cctcagcagc accctgacgc tgagcaaagc agactacgag      240

aaacacaaac tctacgcctg cgaagtcacc catcagggcc tgagctcgcc cgtcacaaag      300

agcttcaaca ggggagagtg t                                                321


<210>  50
<211>  107
<212>  PRT
<213>  HomoSapien

<400>  50

Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu 
1               5                   10                  15      


Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe 
            20                  25                  30          


Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln 
        35                  40                  45              


Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser 
    50                  55                  60                  


Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu 
65                  70                  75                  80  


Lys His Lys Leu Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser 
                85                  90                  95      


Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
            100                 105         


<210>  51
<211>  321
<212>  DNA
<213>  HomoSapien

<400>  51
cgaactgtgg ctgcaccatc tgtcttcatc ttcccgccat ctgatgagca gttgaaatct       60

ggaactgcct ctgttgtgtg cctgctgaat aacttctatc ccagagaggc caaagtacag      120

tggaaggtgg ataacgccct ccaatcgggt aactcccagg agagtgtcac agagcaggac      180

agcaaggaca gcacctacag cctcagcaac accctgacgc tgagcaaagc agactacgag      240

aaacacaaag tctacgcctg cgaagtcacc catcagggcc tgagctcgcc cgtcacaaag      300

agcttcaaca ggggagagtg c                                                321


<210>  52
<211>  107
<212>  PRT
<213>  HomoSapien

<400>  52

Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu 
1               5                   10                  15      


Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe 
            20                  25                  30          


Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln 
        35                  40                  45              


Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser 
    50                  55                  60                  


Thr Tyr Ser Leu Ser Asn Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu 
65                  70                  75                  80  


Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser 
                85                  90                  95      


Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
            100                 105         


<210>  53
<211>  312
<212>  DNA
<213>  HomoSapien

<400>  53
cccaaggcca accccacggt cactctgttc ccgccctcct ctgaggagct ccaagccaac       60

aaggccacac tagtgtgtct gatcagtgac ttctacccgg gagctgtgac agtggcttgg      120

aaggcagatg gcagccccgt caaggcggga gtggagacga ccaaaccctc caaacagagc      180

aacaacaagt acgcggccag cagctacctg agcctgacgc ccgagcagtg gaagtcccac      240

agaagctaca gctgccaggt cacgcatgaa gggagcaccg tggagaagac agtggcccct      300

acagaatgtt ca                                                          312


<210>  54
<211>  104
<212>  PRT
<213>  HomoSapien

<400>  54

Pro Lys Ala Asn Pro Thr Val Thr Leu Phe Pro Pro Ser Ser Glu Glu 
1               5                   10                  15      


Leu Gln Ala Asn Lys Ala Thr Leu Val Cys Leu Ile Ser Asp Phe Tyr 
            20                  25                  30          


Pro Gly Ala Val Thr Val Ala Trp Lys Ala Asp Gly Ser Pro Val Lys 
        35                  40                  45              


Ala Gly Val Glu Thr Thr Lys Pro Ser Lys Gln Ser Asn Asn Lys Tyr 
    50                  55                  60                  


Ala Ala Ser Ser Tyr Leu Ser Leu Thr Pro Glu Gln Trp Lys Ser His 
65                  70                  75                  80  


Arg Ser Tyr Ser Cys Gln Val Thr His Glu Gly Ser Thr Val Glu Lys 
                85                  90                  95      


Thr Val Ala Pro Thr Glu Cys Ser 
            100                 


<210>  55
<211>  318
<212>  DNA
<213>  HomoSapien

<400>  55
ggtcagccca aggccaaccc cactgtcact ctgttcccgc cctcctctga ggagctccaa       60

gccaacaagg ccacactagt gtgtctgatc agtgacttct acccgggagc tgtgacagtg      120

gcctggaagg cagatggcag ccccgtcaag gcgggagtgg agaccaccaa accctccaaa      180

cagagcaaca acaagtacgc ggccagcagc tacctgagcc tgacgcccga gcagtggaag      240

tcccacagaa gctacagctg ccaggtcacg catgaaggga gcaccgtgga gaagacagtg      300

gcccctacag aatgttca                                                    318


<210>  56
<211>  318
<212>  DNA
<213>  HomoSapien

<400>  56
ggtcagccca aggccaaccc cactgtcact ctgttcccgc cctcctctga ggagctccaa       60

gccaacaagg ccacactagt gtgtctgatc agtgacttct acccgggagc tgtgacagtg      120

gcctggaagg cagatggcag ccccgtcaag gcgggagtgg agaccaccaa accctccaaa      180

cagagcaaca acaagtacgc ggccagcagc tacctgagcc tgacgcccga gcagtggaag      240

tcccacagaa gctacagctg ccaggtcacg catgaaggga gcaccgtgga gaagacagtg      300

gcccctacag aatgttca                                                    318


<210>  57
<211>  106
<212>  PRT
<213>  HomoSapien

<400>  57

Gly Gln Pro Lys Ala Asn Pro Thr Val Thr Leu Phe Pro Pro Ser Ser 
1               5                   10                  15      


Glu Glu Leu Gln Ala Asn Lys Ala Thr Leu Val Cys Leu Ile Ser Asp 
            20                  25                  30          


Phe Tyr Pro Gly Ala Val Thr Val Ala Trp Lys Ala Asp Gly Ser Pro 
        35                  40                  45              


Val Lys Ala Gly Val Glu Thr Thr Lys Pro Ser Lys Gln Ser Asn Asn 
    50                  55                  60                  


Lys Tyr Ala Ala Ser Ser Tyr Leu Ser Leu Thr Pro Glu Gln Trp Lys 
65                  70                  75                  80  


Ser His Arg Ser Tyr Ser Cys Gln Val Thr His Glu Gly Ser Thr Val 
                85                  90                  95      


Glu Lys Thr Val Ala Pro Thr Glu Cys Ser 
            100                 105     


<210>  58
<211>  318
<212>  DNA
<213>  HomoSapien

<400>  58
ggccagccta aggccgctcc ttctgtgacc ctgttccccc catcctccga ggaactgcag       60

gctaacaagg ccaccctcgt gtgcctgatc agcgacttct accctggcgc cgtgaccgtg      120

gcctggaagg ctgatagctc tcctgtgaag gccggcgtgg aaaccaccac cccttccaag      180

cagtccaaca acaaatacgc cgcctcctcc tacctgtccc tgacccctga gcagtggaag      240

tcccaccggt cctacagctg ccaagtgacc cacgagggct ccaccgtgga aaagaccgtg      300

gctcctaccg agtgctcc                                                    318


<210>  59
<211>  318
<212>  DNA
<213>  HomoSapien

<400>  59
ggccagccta aagctgcccc cagcgtcacc ctgtttcctc cctccagcga ggagctccag       60

gccaacaagg ccaccctcgt gtgcctgatc tccgacttct atcccggcgc tgtgaccgtg      120

gcttggaaag ccgactccag ccctgtcaaa gccggcgtgg agaccaccac accctccaag      180

cagtccaaca acaagtacgc cgcctccagc tatctctccc tgacccctga gcagtggaag      240

tcccaccggt cctactcctg tcaggtgacc cacgagggct ccaccgtgga aaagaccgtc      300

gcccccaccg agtgctcc                                                    318


<210>  60
<211>  106
<212>  PRT
<213>  HomoSapien

<400>  60

Gly Gln Pro Lys Ala Ala Pro Ser Val Thr Leu Phe Pro Pro Ser Ser 
1               5                   10                  15      


Glu Glu Leu Gln Ala Asn Lys Ala Thr Leu Val Cys Leu Ile Ser Asp 
            20                  25                  30          


Phe Tyr Pro Gly Ala Val Thr Val Ala Trp Lys Ala Asp Ser Ser Pro 
        35                  40                  45              


Val Lys Ala Gly Val Glu Thr Thr Thr Pro Ser Lys Gln Ser Asn Asn 
    50                  55                  60                  


Lys Tyr Ala Ala Ser Ser Tyr Leu Ser Leu Thr Pro Glu Gln Trp Lys 
65                  70                  75                  80  


Ser His Arg Ser Tyr Ser Cys Gln Val Thr His Glu Gly Ser Thr Val 
                85                  90                  95      


Glu Lys Thr Val Ala Pro Thr Glu Cys Ser 
            100                 105     


<210>  61
<211>  318
<212>  DNA
<213>  HomoSapien

<400>  61
ggtcagccca aggctgcccc ctcggtcact ctgttcccgc cctcctctga ggagcttcaa       60

gccaacaagg ccacactggt gtgtctcata agtgacttct acccgggagc cgtgacagtg      120

gcctggaagg cagatagcag ccccgtcaag gcgggagtgg agaccaccac accctccaaa      180

caaagcaaca acaagtacgc ggccagcagc tatctgagcc tgacgcctga gcagtggaag      240

tcccacagaa gctacagctg ccaggtcacg catgaaggga gcaccgtgga gaagacagtg      300

gcccctacag aatgttca                                                    318


<210>  62
<211>  106
<212>  PRT
<213>  HomoSapien

<400>  62

Gly Gln Pro Lys Ala Ala Pro Ser Val Thr Leu Phe Pro Pro Ser Ser 
1               5                   10                  15      


Glu Glu Leu Gln Ala Asn Lys Ala Thr Leu Val Cys Leu Ile Ser Asp 
            20                  25                  30          


Phe Tyr Pro Gly Ala Val Thr Val Ala Trp Lys Ala Asp Ser Ser Pro 
        35                  40                  45              


Val Lys Ala Gly Val Glu Thr Thr Thr Pro Ser Lys Gln Ser Asn Asn 
    50                  55                  60                  


Lys Tyr Ala Ala Ser Ser Tyr Leu Ser Leu Thr Pro Glu Gln Trp Lys 
65                  70                  75                  80  


Ser His Arg Ser Tyr Ser Cys Gln Val Thr His Glu Gly Ser Thr Val 
                85                  90                  95      


Glu Lys Thr Val Ala Pro Thr Glu Cys Ser 
            100                 105     


<210>  63
<211>  312
<212>  DNA
<213>  HomoSapien

<400>  63
cccaaggctg ccccctcggt cactctgttc ccaccctcct ctgaggagct tcaagccaac       60

aaggccacac tggtgtgtct cataagtgac ttctacccgg gagccgtgac agttgcctgg      120

aaggcagata gcagccccgt caaggcgggg gtggagacca ccacaccctc caaacaaagc      180

aacaacaagt acgcggccag cagctacctg agcctgacgc ctgagcagtg gaagtcccac      240

aaaagctaca gctgccaggt cacgcatgaa gggagcaccg tggagaagac agttgcccct      300

acggaatgtt ca                                                          312


<210>  64
<211>  104
<212>  PRT
<213>  HomoSapien

<400>  64

Pro Lys Ala Ala Pro Ser Val Thr Leu Phe Pro Pro Ser Ser Glu Glu 
1               5                   10                  15      


Leu Gln Ala Asn Lys Ala Thr Leu Val Cys Leu Ile Ser Asp Phe Tyr 
            20                  25                  30          


Pro Gly Ala Val Thr Val Ala Trp Lys Ala Asp Ser Ser Pro Val Lys 
        35                  40                  45              


Ala Gly Val Glu Thr Thr Thr Pro Ser Lys Gln Ser Asn Asn Lys Tyr 
    50                  55                  60                  


Ala Ala Ser Ser Tyr Leu Ser Leu Thr Pro Glu Gln Trp Lys Ser His 
65                  70                  75                  80  


Lys Ser Tyr Ser Cys Gln Val Thr His Glu Gly Ser Thr Val Glu Lys 
                85                  90                  95      


Thr Val Ala Pro Thr Glu Cys Ser 
            100                 


<210>  65
<211>  318
<212>  DNA
<213>  HomoSapien

<400>  65
ggtcagccca aggctgcccc ctcggtcact ctgttcccac cctcctctga ggagcttcaa       60

gccaacaagg ccacactggt gtgtctcata agtgacttct acccggggcc agtgacagtt      120

gcctggaagg cagatagcag ccccgtcaag gcgggggtgg agaccaccac accctccaaa      180

caaagcaaca acaagtacgc ggccagcagc tacctgagcc tgacgcctga gcagtggaag      240

tcccacaaaa gctacagctg ccaggtcacg catgaaggga gcaccgtgga gaagacagtg      300

gcccctacgg aatgttca                                                    318


<210>  66
<211>  106
<212>  PRT
<213>  HomoSapien

<400>  66

Gly Gln Pro Lys Ala Ala Pro Ser Val Thr Leu Phe Pro Pro Ser Ser 
1               5                   10                  15      


Glu Glu Leu Gln Ala Asn Lys Ala Thr Leu Val Cys Leu Ile Ser Asp 
            20                  25                  30          


Phe Tyr Pro Gly Pro Val Thr Val Ala Trp Lys Ala Asp Ser Ser Pro 
        35                  40                  45              


Val Lys Ala Gly Val Glu Thr Thr Thr Pro Ser Lys Gln Ser Asn Asn 
    50                  55                  60                  


Lys Tyr Ala Ala Ser Ser Tyr Leu Ser Leu Thr Pro Glu Gln Trp Lys 
65                  70                  75                  80  


Ser His Lys Ser Tyr Ser Cys Gln Val Thr His Glu Gly Ser Thr Val 
                85                  90                  95      


Glu Lys Thr Val Ala Pro Thr Glu Cys Ser 
            100                 105     


<210>  67
<211>  318
<212>  DNA
<213>  HomoSapien

<400>  67
ggtcagccca aggctgcccc ctcggtcact ctgttcccac cctcctctga ggagcttcaa       60

gccaacaagg ccacactggt gtgtctcata agtgacttct acccgggagc cgtgacagtg      120

gcctggaagg cagatagcag ccccgtcaag gcgggagtgg agaccaccac accctccaaa      180

caaagcaaca acaagtacgc ggccagcagc tacctgagcc tgacgcctga gcagtggaag      240

tcccacaaaa gctacagctg ccaggtcacg catgaaggga gcaccgtgga gaagacagtg      300

gcccctacag aatgttca                                                    318


<210>  68
<211>  106
<212>  PRT
<213>  HomoSapien

<400>  68

Gly Gln Pro Lys Ala Ala Pro Ser Val Thr Leu Phe Pro Pro Ser Ser 
1               5                   10                  15      


Glu Glu Leu Gln Ala Asn Lys Ala Thr Leu Val Cys Leu Ile Ser Asp 
            20                  25                  30          


Phe Tyr Pro Gly Ala Val Thr Val Ala Trp Lys Ala Asp Ser Ser Pro 
        35                  40                  45              


Val Lys Ala Gly Val Glu Thr Thr Thr Pro Ser Lys Gln Ser Asn Asn 
    50                  55                  60                  


Lys Tyr Ala Ala Ser Ser Tyr Leu Ser Leu Thr Pro Glu Gln Trp Lys 
65                  70                  75                  80  


Ser His Lys Ser Tyr Ser Cys Gln Val Thr His Glu Gly Ser Thr Val 
                85                  90                  95      


Glu Lys Thr Val Ala Pro Thr Glu Cys Ser 
            100                 105     


<210>  69
<211>  318
<212>  DNA
<213>  HomoSapien

<400>  69
ggtcagccca aggctgcccc ctcggtcact ctgttcccgc cctcctctga ggagcttcaa       60

gccaacaagg ccacactggt gtgtctcata agtgacttct acccgggagc cgtgacagtg      120

gcctggaagg cagatagcag ccccgtcaag gcgggagtgg agaccaccac accctccaaa      180

caaagcaaca acaagtacgc ggccagcagc tacctgagcc tgacgcctga gcagtggaag      240

tcccacagaa gctacagctg ccaggtcacg catgaaggga gcaccgtgga gaagacagtg      300

gcccctacag aatgttca                                                    318


<210>  70
<211>  106
<212>  PRT
<213>  HomoSapien

<400>  70

Gly Gln Pro Lys Ala Ala Pro Ser Val Thr Leu Phe Pro Pro Ser Ser 
1               5                   10                  15      


Glu Glu Leu Gln Ala Asn Lys Ala Thr Leu Val Cys Leu Ile Ser Asp 
            20                  25                  30          


Phe Tyr Pro Gly Ala Val Thr Val Ala Trp Lys Ala Asp Ser Ser Pro 
        35                  40                  45              


Val Lys Ala Gly Val Glu Thr Thr Thr Pro Ser Lys Gln Ser Asn Asn 
    50                  55                  60                  


Lys Tyr Ala Ala Ser Ser Tyr Leu Ser Leu Thr Pro Glu Gln Trp Lys 
65                  70                  75                  80  


Ser His Arg Ser Tyr Ser Cys Gln Val Thr His Glu Gly Ser Thr Val 
                85                  90                  95      


Glu Lys Thr Val Ala Pro Thr Glu Cys Ser 
            100                 105     


<210>  71
<211>  318
<212>  DNA
<213>  HomoSapien

<400>  71
ggtcagccca aggctgcccc atcggtcact ctgttcccgc cctcctctga ggagcttcaa       60

gccaacaagg ccacactggt gtgcctgatc agtgacttct acccgggagc tgtgaaagtg      120

gcctggaagg cagatggcag ccccgtcaac acgggagtgg agaccaccac accctccaaa      180

cagagcaaca acaagtacgc ggccagcagc tacctgagcc tgacgcctga gcagtggaag      240

tcccacagaa gctacagctg ccaggtcacg catgaaggga gcaccgtgga gaagacagtg      300

gcccctgcag aatgttca                                                    318


<210>  72
<211>  106
<212>  PRT
<213>  HomoSapien

<400>  72

Gly Gln Pro Lys Ala Ala Pro Ser Val Thr Leu Phe Pro Pro Ser Ser 
1               5                   10                  15      


Glu Glu Leu Gln Ala Asn Lys Ala Thr Leu Val Cys Leu Ile Ser Asp 
            20                  25                  30          


Phe Tyr Pro Gly Ala Val Lys Val Ala Trp Lys Ala Asp Gly Ser Pro 
        35                  40                  45              


Val Asn Thr Gly Val Glu Thr Thr Thr Pro Ser Lys Gln Ser Asn Asn 
    50                  55                  60                  


Lys Tyr Ala Ala Ser Ser Tyr Leu Ser Leu Thr Pro Glu Gln Trp Lys 
65                  70                  75                  80  


Ser His Arg Ser Tyr Ser Cys Gln Val Thr His Glu Gly Ser Thr Val 
                85                  90                  95      


Glu Lys Thr Val Ala Pro Ala Glu Cys Ser 
            100                 105     


<210>  73
<211>  318
<212>  DNA
<213>  HomoSapien

<400>  73
ggtcagccca aggctgcccc atcggtcact ctgttcccac cctcctctga ggagcttcaa       60

gccaacaagg ccacactggt gtgtctcgta agtgacttct acccgggagc cgtgacagtg      120

gcctggaagg cagatggcag ccccgtcaag gtgggagtgg agaccaccaa accctccaaa      180

caaagcaaca acaagtatgc ggccagcagc tacctgagcc tgacgcccga gcagtggaag      240

tcccacagaa gctacagctg ccgggtcacg catgaaggga gcaccgtgga gaagacagtg      300

gcccctgcag aatgctct                                                    318


<210>  74
<211>  106
<212>  PRT
<213>  HomoSapien

<400>  74

Gly Gln Pro Lys Ala Ala Pro Ser Val Thr Leu Phe Pro Pro Ser Ser 
1               5                   10                  15      


Glu Glu Leu Gln Ala Asn Lys Ala Thr Leu Val Cys Leu Val Ser Asp 
            20                  25                  30          


Phe Tyr Pro Gly Ala Val Thr Val Ala Trp Lys Ala Asp Gly Ser Pro 
        35                  40                  45              


Val Lys Val Gly Val Glu Thr Thr Lys Pro Ser Lys Gln Ser Asn Asn 
    50                  55                  60                  


Lys Tyr Ala Ala Ser Ser Tyr Leu Ser Leu Thr Pro Glu Gln Trp Lys 
65                  70                  75                  80  


Ser His Arg Ser Tyr Ser Cys Arg Val Thr His Glu Gly Ser Thr Val 
                85                  90                  95      


Glu Lys Thr Val Ala Pro Ala Glu Cys Ser 
            100                 105     


<210>  75
<211>  318
<212>  DNA
<213>  HomoSapien

<400>  75
ggtcagccca aggctgcccc ctcggtcact ctgttcccac cctcctctga ggagcttcaa       60

gccaacaagg ccacactggt gtgtctcgta agtgacttca acccgggagc cgtgacagtg      120

gcctggaagg cagatggcag ccccgtcaag gtgggagtgg agaccaccaa accctccaaa      180

caaagcaaca acaagtatgc ggccagcagc tacctgagcc tgacgcccga gcagtggaag      240

tcccacagaa gctacagctg ccgggtcacg catgaaggga gcaccgtgga gaagacagtg      300

gcccctgcag aatgctct                                                    318


<210>  76
<211>  106
<212>  PRT
<213>  HomoSapien

<400>  76

Gly Gln Pro Lys Ala Ala Pro Ser Val Thr Leu Phe Pro Pro Ser Ser 
1               5                   10                  15      


Glu Glu Leu Gln Ala Asn Lys Ala Thr Leu Val Cys Leu Val Ser Asp 
            20                  25                  30          


Phe Asn Pro Gly Ala Val Thr Val Ala Trp Lys Ala Asp Gly Ser Pro 
        35                  40                  45              


Val Lys Val Gly Val Glu Thr Thr Lys Pro Ser Lys Gln Ser Asn Asn 
    50                  55                  60                  


Lys Tyr Ala Ala Ser Ser Tyr Leu Ser Leu Thr Pro Glu Gln Trp Lys 
65                  70                  75                  80  


Ser His Arg Ser Tyr Ser Cys Arg Val Thr His Glu Gly Ser Thr Val 
                85                  90                  95      


Glu Lys Thr Val Ala Pro Ala Glu Cys Ser 
            100                 105     


<210>  77
<211>  354
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Truncated human lambda 5 coding region

<400>  77
gtgtttggca gcgggaccca gctcaccgtt ttaagtcagc ccaaggccac cccctcggtc       60

actctgttcc cgccgtcctc tgaggagctc caagccaaca aggctacact ggtgtgtctc      120

atgaatgact tttatccggg aatcttgacg gtgacctgga aggcagatgg tacccccatc      180

acccagggcg tggagatgac cacgccctcc aaacagagca acaacaagta cgcggccagc      240

agctacctga gcctgacgcc cgagcagtgg aggtcccgca gaagctacag ctgccaggtc      300

atgcacgaag ggagcaccgt ggagaagacg gtggcccctg cagaatgttc atag            354


<210>  78
<211>  2950
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Human Kappa promoter and leader with intron including Human kappa
       intronic enhancer human Vk1-5 derived

<400>  78
atggacatga gggtccccgc tcagctcctg gggctcctgc tgctctggct cccaggtaag       60

taatttttca ctattgtctt ctgaaatttg ggtctgatgg ccagtattga cttttagagg      120

cttaaatagg agtttggtaa agattggtaa atgagggcat ttaagatttg ccatgggttg      180

caaaagttaa actcagcttc aaaaatggat ttggagaaaa aaagattaaa ttgctctaaa      240

ctgaatgaca caaagtaaaa aaaaaaagtg taactaaaaa ggaacccttg tatttctaag      300

gagcaaaagt aaatttattt ttgttcactc ttgccaaata ttgtattggt tgttgctgat      360

tatgcatgat acagaaaagt ggaaaaatac attttttagt ctttctccct tttgtttgat      420

aaattatttt gtcagacaac aataaaaatc aatagcacgc cctaagaaaa atcagggaaa      480

agtgaagtgt acctatttgc tatgtagaag aggcagctta cttgaaaatc agcagcaatg      540

ttgtttttag agtctgtaat aagtaataaa ctcaaaaaga cacattctat aggaataagg      600

gcttcacaga tagagctcat tttttaaaaa tccaatttgt acattagact aaacgtgaaa      660

ttatctctta ttgtaatggt ggaaaggtgg ttattcccaa aagctcaatc tcaaagaaat      720

gtgtttaaat gaaaaaaagt aaataattgc attttttaat gaccgtgggt ctgtgaaaaa      780

aataggaaat attttaaaga gtatgttctt tcattatcct ctgttattac ttgtctacat      840

ttttattctg ccaagaaggc cgtggcaccg cgagctgtag acagagccgc ggtctttctc      900

gattgagtgg ctttggtggc catgccaccg cgctcttggg gcagccgcct tgccgctagt      960

ggccgtggcc accctgtgtc tgcccgattg atgctgccgt agccagcttt cctgatgcac     1020

agtgatacaa ataatgccac taagggaaag agaacagaaa cgtaatgggc gctgagctgg     1080

gaaaaccagg gagaagactg atttattaga gatttcagaa ataaaattca cattcattat     1140

gatatctcat tagtgaaaat ttccattagg ggattgtaaa taatttaaag cttttttttt     1200

tttcagtgct atttaattat ttcaatatcc tctcatcaaa tgtatttaaa taacaaaagc     1260

tcaaccaaaa agaaagaaat atgtaattct ttcagagtaa aaatcacacc catgacctgg     1320

ccactgaggg cttgatcaat tcactttgaa tttggcatta aataccatta aggtatatta     1380

actgatttta aaataagata tattcgtgac catgttttta actttcaaaa atgtagctgc     1440

cagtgtgtga ttttatttca gttgtacaaa atatctaaac ctatagcaat gtgattaata     1500

aaaacttaaa catattttcc agtaccttaa ttctgtgata ggaaaatttt aatctgagta     1560

ttttaatttc ataatctcta aaatagttta atgatttgtc attgtgttgc tgtcgtttac     1620

cccagctgat ctcaaaagtg atatttaagg agattatttt ggtctgcaac aacttgatag     1680

gactatttta gggccttttt aaagctctat taaaactaac ttacaacgat tcaaaactgt     1740

tttaaactat ttcaaaatga ttttagagcc ttttgaaaac tcttttaaac actttttaaa     1800

ctctattaaa actaataaga taacttgaaa taattttcat gtcaaataca ttaactgttt     1860

aatgtttaaa tgccagatga aaaatgtaaa gctatcaaga attcacccag ataggagtat     1920

cttcatagca tgtttttccc tgcttatttt ccagtgatca cattattttg ctaccatggt     1980

tattttatac aattatctga aaaaaattag ttatgaagat taaaagagaa gaaaatatta     2040

aacataagag attcagtctt tcatgttgaa ctgcttggtt aacagtgaag ttagttttaa     2100

aaaaaaaaaa aactatttct gttatcagct gacttctccc tatctgttga cttctcccag     2160

caaaagattc ttattttaca ttttaactac tgctctccca cccaacgggt ggaatccccc     2220

agagggggat ttccaagagg ccacctggca gttgctgagg gtcagaagtg aagctagcca     2280

cttcctctta ggcaggtggc caagattaca gttgacctct cctggtatgg ctgaaaattg     2340

ctgcatatgg ttacaggcct tgaggccttt gggagggctt agagagttgc tggaacagtc     2400

agaaggtgga ggggctgaca ccacccaggc gcagaggcag ggctcagggc ctgctctgca     2460

gggaggtttt agcccagccc agccaaagta acccccggga gcctgttatc ccagcacagt     2520

cctggaagag gcacagggga aataaaagcg gacggaggct ttccttgact cagccgctgc     2580

ctggtcttct tcagacctgt tctgaattct aaactctgag ggggtcggat gacgtggcca     2640

ttctttgcct aaagcattga gtttactgca aggtcagaaa agcatgcaaa gccctcagaa     2700

tggctgcaaa gagctccaac aaaacaattt agaactttat taaggaatag ggggaagcta     2760

ggaagaaact caaaacatca agattttaaa tacgcttctt ggtctccttg ctataattat     2820

ctgggataag catgctgttt tctgtctgtc cctaacatgc cctgtgatta tccgcaaaca     2880

acacacccaa gggcagaact ttgttactta aacaccatcc tgtttgcttc tttcctcagg     2940

tgccaaatgt                                                            2950


<210>  79
<211>  6088
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Full lambda 5 transgene plus homology arms

<400>  79
gctgaatctt gaatgacagc tcaagggata gggaggacag ggtgttcaga agcagagaag       60

atgccttgta aatgtggaag gctgtggcag gattggaagg actttggggt ggtaggaagg      120

ggatgggaat gggtggttac aagagaaaca agactgtagt aaataaagct gaaactcaaa      180

gcaagctttc agcatcttta attggagaca caaacttcaa aggtatcatg aatgtggttg      240

atcttggtga aagttgagct tcacctgtcc taacaacaga ccaatccatg agtgaaagct      300

tatctttctc ctttattaat ggttgctgtt gtatccataa ctcaattcca aaggatatga      360

accttaacat atagatataa ttttgtgtac cttctatgaa acagcattaa agcaaagaag      420

ttcaaataga aagactggct tagttattat taactaagag atgctagtga gttctaaatt      480

aataccattt aaaatttata atttgcagaa ttaccaccac caccaccact cagcccagga      540

aaagttacaa agaactggct atccaatttg tttgttttcc tcctttttag agttctttta      600

tttatgtgtg agtgaatgcc atgtacttat ggatgcagag gctgtcagat tccttgcagc      660

tggagtaata gacagttgtg agctacttat agtactagaa ctaagatcct atggaagagc      720

agcgagtgcc actaactgct gagccacctc tccagcccat ttctttattt ttcaatgaac      780

aaataataag cagtcctatg tgacatgctt ctaaagcaaa agatataata tttagtatta      840

tatacattaa taataaaata cattatcttc taagaattga agtctcaact atgaaaatca      900

gcagttctct gtcagagaag atgtccagtt tcatctggat ccaactgatt tctccatgta      960

catagacaat tgcttgataa gagattgagt atgtttttcc taaaggtgtt aacagggagg     1020

ctggtgtctg ggtcaggatg atgtccccat gcactgataa aaagtataag aagaaagtgt     1080

cattgatggt gcatggcagg gacatgctcc gtgcagtggc caccctcact aagacagatg     1140

aactttggga aataataccc aatggcagaa aagaaggtag actatgaagg tacccaaaac     1200

aagaataagg tgcacctcat ttagtctctg ggtattaaag agacctgcag ttcttgatag     1260

tggtggatct gtgagtgctg catgcatgga gacaacacgg tatcatcttt gtatatctgt     1320

aataaattgc ttgatctaat actagtaaga acaaaggcat aacaccatta cctaatactt     1380

acaaatatat agcatcatgc cgatacattt tatttttaat tttttttaga aaggaacaat     1440

gttaaactca cagaaatgtt gcaggtatag cacaattacc cccttcccta cccggaatct     1500

tatgagagtc ttttgaagac ttgagaatcc taccatctaa cattttacta tgtgtttcct     1560

acaaacaaga atattctcct aaataatcct gatacaccaa tgaaatacat tactctatcg     1620

gctcctgagg aatatttaaa attctcaaaa aaatacctaa aaattgtttc tcataataaa     1680

atagtcccca gtagaaacac attctctgca gacaaatttg tgctaccctg gtcttacctg     1740

ggacacctgg ggacactgag ctggtgctga gttactgaga tgagccagct ctgcagctgt     1800

gcccagcctg ccccatcccc tgctcatttg catgttccca gagcacaacc tcctgccctg     1860

aagccttatt aataggctgg tcacactttg tgcaggagtc agacccagtc aggacacagc     1920

atggacatga gggtccccgc tcagctcctg gggctcctgc tgctctggct cccaggtaag     1980

taatttttca ctattgtctt ctgaaatttg ggtctgatgg ccagtattga cttttagagg     2040

cttaaatagg agtttggtaa agattggtaa atgagggcat ttaagatttg ccatgggttg     2100

caaaagttaa actcagcttc aaaaatggat ttggagaaaa aaagattaaa ttgctctaaa     2160

ctgaatgaca caaagtaaaa aaaaaaagtg taactaaaaa ggaacccttg tatttctaag     2220

gagcaaaagt aaatttattt ttgttcactc ttgccaaata ttgtattggt tgttgctgat     2280

tatgcatgat acagaaaagt ggaaaaatac attttttagt ctttctccct tttgtttgat     2340

aaattatttt gtcagacaac aataaaaatc aatagcacgc cctaagaaaa atcagggaaa     2400

agtgaagtgt acctatttgc tatgtagaag aggcagctta cttgaaaatc agcagcaatg     2460

ttgtttttag agtctgtaat aagtaataaa ctcaaaaaga cacattctat aggaataagg     2520

gcttcacaga tagagctcat tttttaaaaa tccaatttgt acattagact aaacgtgaaa     2580

ttatctctta ttgtaatggt ggaaaggtgg ttattcccaa aagctcaatc tcaaagaaat     2640

gtgtttaaat gaaaaaaagt aaataattgc attttttaat gaccgtgggt ctgtgaaaaa     2700

aataggaaat attttaaaga gtatgttctt tcattatcct ctgttattac ttgtctacat     2760

ttttattctg ccaagaaggc cgtggcaccg cgagctgtag acagagccgc ggtctttctc     2820

gattgagtgg ctttggtggc catgccaccg cgctcttggg gcagccgcct tgccgctagt     2880

ggccgtggcc accctgtgtc tgcccgattg atgctgccgt agccagcttt cctgatgcac     2940

agtgatacaa ataatgccac taagggaaag agaacagaaa cgtaatgggc gctgagctgg     3000

gaaaaccagg gagaagactg atttattaga gatttcagaa ataaaattca cattcattat     3060

gatatctcat tagtgaaaat ttccattagg ggattgtaaa taatttaaag cttttttttt     3120

tttcagtgct atttaattat ttcaatatcc tctcatcaaa tgtatttaaa taacaaaagc     3180

tcaaccaaaa agaaagaaat atgtaattct ttcagagtaa aaatcacacc catgacctgg     3240

ccactgaggg cttgatcaat tcactttgaa tttggcatta aataccatta aggtatatta     3300

actgatttta aaataagata tattcgtgac catgttttta actttcaaaa atgtagctgc     3360

cagtgtgtga ttttatttca gttgtacaaa atatctaaac ctatagcaat gtgattaata     3420

aaaacttaaa catattttcc agtaccttaa ttctgtgata ggaaaatttt aatctgagta     3480

ttttaatttc ataatctcta aaatagttta atgatttgtc attgtgttgc tgtcgtttac     3540

cccagctgat ctcaaaagtg atatttaagg agattatttt ggtctgcaac aacttgatag     3600

gactatttta gggccttttt aaagctctat taaaactaac ttacaacgat tcaaaactgt     3660

tttaaactat ttcaaaatga ttttagagcc ttttgaaaac tcttttaaac actttttaaa     3720

ctctattaaa actaataaga taacttgaaa taattttcat gtcaaataca ttaactgttt     3780

aatgtttaaa tgccagatga aaaatgtaaa gctatcaaga attcacccag ataggagtat     3840

cttcatagca tgtttttccc tgcttatttt ccagtgatca cattattttg ctaccatggt     3900

tattttatac aattatctga aaaaaattag ttatgaagat taaaagagaa gaaaatatta     3960

aacataagag attcagtctt tcatgttgaa ctgcttggtt aacagtgaag ttagttttaa     4020

aaaaaaaaaa aactatttct gttatcagct gacttctccc tatctgttga cttctcccag     4080

caaaagattc ttattttaca ttttaactac tgctctccca cccaacgggt ggaatccccc     4140

agagggggat ttccaagagg ccacctggca gttgctgagg gtcagaagtg aagctagcca     4200

cttcctctta ggcaggtggc caagattaca gttgacctct cctggtatgg ctgaaaattg     4260

ctgcatatgg ttacaggcct tgaggccttt gggagggctt agagagttgc tggaacagtc     4320

agaaggtgga ggggctgaca ccacccaggc gcagaggcag ggctcagggc ctgctctgca     4380

gggaggtttt agcccagccc agccaaagta acccccggga gcctgttatc ccagcacagt     4440

cctggaagag gcacagggga aataaaagcg gacggaggct ttccttgact cagccgctgc     4500

ctggtcttct tcagacctgt tctgaattct aaactctgag ggggtcggat gacgtggcca     4560

ttctttgcct aaagcattga gtttactgca aggtcagaaa agcatgcaaa gccctcagaa     4620

tggctgcaaa gagctccaac aaaacaattt agaactttat taaggaatag ggggaagcta     4680

ggaagaaact caaaacatca agattttaaa tacgcttctt ggtctccttg ctataattat     4740

ctgggataag catgctgttt tctgtctgtc cctaacatgc cctgtgatta tccgcaaaca     4800

acacacccaa gggcagaact ttgttactta aacaccatcc tgtttgcttc tttcctcagg     4860

tgccaaatgt gtgtttggca gcgggaccca gctcaccgtt ttaagtcagc ccaaggccac     4920

cccctcggtc actctgttcc cgccgtcctc tgaggagctc caagccaaca aggctacact     4980

ggtgtgtctc atgaatgact tttatccggg aatcttgacg gtgacctgga aggcagatgg     5040

tacccccatc acccagggcg tggagatgac cacgccctcc aaacagagca acaacaagta     5100

cgcggccagc agctacctga gcctgacgcc cgagcagtgg aggtcccgca gaagctacag     5160

ctgccaggtc atgcacgaag ggagcaccgt ggagaagacg gtggcccctg cagaatgttc     5220

atagagacaa aggtcctgag acgccaccac cagctcccca gctccatcct atcttccctt     5280

ctaaggtctt ggaggcttcc ccacaagcga cctaccactg ttgcggtgct ccaaacctcc     5340

tccccacctc cttctcctcc tcctcccttt ccttggcttt tatcatgcta atatttgcag     5400

aaaatattca ataaagtgag tctttgcact tgagatctct gtctttctta ctaaatggta     5460

gtaatcagtt gtttttccag ttacctgggt ttctcttcta aagaagttaa atgtttagtt     5520

gccctgaaat ccaccacact taaaggataa ataaaaccct ccacttgccc tggttggctg     5580

tccactacat ggcagtcctt tctaaggttc acgagtacta ttcatggctt atttctctgg     5640

gccatggtag gtttgaggag gcatacttcc tagttttctt cccctaagtc gtcaaagtcc     5700

tgaaggggga cagtctttac aagcacatgt tctgtaatct gattcaacct acccagtaaa     5760

cttggcgaag caaagtagaa tcattatcac aggaagcaaa ggcaacctaa atgtgcaagc     5820

aataggaaaa tgtggaagcc catcatagta cttggacttc atctgctttt gtgccttcac     5880

taagttttta aacatgagct ggctcctatc tgccattggc aaggctgggc actacccaca     5940

acctacttca aggacctcta taccgtgaga ttacacacat acatcaaaat ttgggaaaag     6000

ttctaccaag ctgagagctg atcaccccac tcttaggtgc ttatctctgt acaccagaaa     6060

ccttaagaag caaccagtat tgagagac                                        6088


<210>  80
<211>  9079
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Full lambda 5 targeting vector insert including positive negative
       selection cassette

<400>  80
gctgaatctt gaatgacagc tcaagggata gggaggacag ggtgttcaga agcagagaag       60

atgccttgta aatgtggaag gctgtggcag gattggaagg actttggggt ggtaggaagg      120

ggatgggaat gggtggttac aagagaaaca agactgtagt aaataaagct gaaactcaaa      180

gcaagctttc agcatcttta attggagaca caaacttcaa aggtatcatg aatgtggttg      240

atcttggtga aagttgagct tcacctgtcc taacaacaga ccaatccatg agtgaaagct      300

tatctttctc ctttattaat ggttgctgtt gtatccataa ctcaattcca aaggatatga      360

accttaacat atagatataa ttttgtgtac cttctatgaa acagcattaa agcaaagaag      420

ttcaaataga aagactggct tagttattat taactaagag atgctagtga gttctaaatt      480

aataccattt aaaatttata atttgcagaa ttaccaccac caccaccact cagcccagga      540

aaagttacaa agaactggct atccaatttg tttgttttcc tcctttttag agttctttta      600

tttatgtgtg agtgaatgcc atgtacttat ggatgcagag gctgtcagat tccttgcagc      660

tggagtaata gacagttgtg agctacttat agtactagaa ctaagatcct atggaagagc      720

agcgagtgcc actaactgct gagccacctc tccagcccat ttctttattt ttcaatgaac      780

aaataataag cagtcctatg tgacatgctt ctaaagcaaa agatataata tttagtatta      840

tatacattaa taataaaata cattatcttc taagaattga agtctcaact atgaaaatca      900

gcagttctct gtcagagaag atgtccagtt tcatctggat ccaactgatt tctccatgta      960

catagacaat tcttttaacc ctagaaagat agtctgcgta aaattgacgc atgcattctt     1020

gaaatattgc tctctctttc taaatagcgc gaatccgtcg ctgtgcattt aggacatctc     1080

agtcgccgct tggagctccc gtgaggcgtg cttgtcaatg cggtaagtgt cactgatttt     1140

gaactataac gaccgcgtga gtcaaaatga cgcatgatta tcttttacgt gacttttaag     1200

atttaactca tacgataatt atattgttat ttcatgttct acttacgtga taacttatta     1260

tatatatatt ttcttgttat agatatctac cgggtagggg aggcgctttt cccaaggcag     1320

tctggagcat gcgctttagc agccccgctg ggcacttggc gctacacaag tggcctctgg     1380

cctcgcacac attccacatc caccggtagg cgccaaccgg ctccgttctt tggtggcccc     1440

ttcgcgccac cttctactcc tcccctagtc aggaagttcc cccccgcccc gcagctcgcg     1500

tcgtgcagga cgtgacaaat ggaagtagca cgtctcacta gtctcgtgca gatggacagc     1560

accgctgagc aatggaagcg ggtaggcctt tggggcagcg gccaatagca gctttgctcc     1620

ttcgctttct gggctcagag gctgggaagg ggtgggtccg ggggcgggct caggggcggg     1680

ctcaggggcg gggcgggcgc ccgaaggtcc tccggaggcc cggcattctg cacgcttcaa     1740

aagcgcacgt ctgccgcgct gttctcctct tcctcatctc cgggcctttc gacctgcagc     1800

caacgccacc atggggaccg agtacaagcc cacggtgcgc ctcgccaccc gcgacgacgt     1860

cccccgggcc gtacgcaccc tcgccgccgc gttcgccgac taccccgcca cgcgccacac     1920

cgtcgacccg gaccgccaca tcgagcgggt caccgagctg caagaactct tcctcacgcg     1980

cgtcgggctc gacatcggca aggtgtgggt cgcggacgac ggcgccgcgg tggcggtctg     2040

gaccacgccg gagagcgtcg aagcgggggc ggtgttcgcc gagatcggcc cgcgcatggc     2100

cgagttgagc ggttcccggc tggccgcgca gcaacagatg gaaggcctcc tggcgccgca     2160

ccggcccaag gagcccgcgt ggttcctggc caccgtcggc gtctcgcccg accaccaggg     2220

caagggtctg ggcagcgccg tcgtgctccc cggagtggag gcggccgagc gcgccggggt     2280

gcccgccttc ctggagacct ccgcgccccg caacctcccc ttctacgagc ggctcggctt     2340

caccgtcacc gccgacgtcg aggtgcccga aggaccgcgc acctggtgca tgacccgcaa     2400

gcccggtgcc ggatccatgc ccacgctact gcgggtttat atagacggtc ctcacgggat     2460

ggggaaaacc accaccacgc aactgctggt ggccctgggt tcgcgcgacg atatcgtcta     2520

cgtacccgag ccgatgactt actggcaggt gctgggggct tccgagacaa tcgcgaacat     2580

ctacaccaca caacaccgcc tcgaccaggg tgagatatcg gccggggacg cggcggtggt     2640

aatgacaagc gcccagataa caatgggcat gccttatgcc gtgaccgacg ccgttctggc     2700

tcctcatatc gggggggagg ctgggagctc acatgccccg cccccggccc tcaccctcat     2760

cttcgaccgc catcccatcg ccgccctcct gtgctacccg gccgcgcgat accttatggg     2820

cagcatgacc ccccaggccg tgctggcgtt cgtggccctc atcccgccga ccttgcccgg     2880

cacaaacatc gtgttggggg cccttccgga ggacagacac atcgaccgcc tggccaaacg     2940

ccagcgcccc ggcgagcggc ttgacctggc tatgctggcc gcgattcgcc gcgtttacgg     3000

gctgcttgcc aatacggtgc ggtatctgca gggcggcggg tcgtggcggg aggattgggg     3060

acagctttcg gggacggccg tgccgcccca gggtgccgag ccccagagca acgcgggccc     3120

acgaccccat atcggggaca cgttatttac cctgtttcgg gcccccgagt tgctggcccc     3180

caacggcgac ctgtacaacg tgtttgcctg ggccttggac gtcttggcca aacgcctccg     3240

tcccatgcac gtctttatcc tggattacga ccaatcgccc gccggctgcc gggacgccct     3300

gctgcaactt acctccggga tggtccagac ccacgtcacc acccccggct ccataccgac     3360

gatctgcgac ctggcgcgca cgtttgcccg ggagatgggg gaggctaact gagctctaga     3420

gctcgctgat cagcctcgac tgtgccttct agttgccagc catctgttgt ttgcccctcc     3480

cccgtgcctt ccttgaccct ggaaggtgcc actcccactg tcctttccta ataaaatgag     3540

gaaattgcat cgcattgtct gagtaggtgt cattctattc tggggggtgg ggtggggcag     3600

gacagcaagg gggaggattg ggaagacaat agcaggcatg ctggggatgc ggtgggctct     3660

atggcttctg aggcggaaag aaccagctgg ggctcgagat ccactagtta aaagttttgt     3720

tactttatag aagaaatttt gagtttttgt ttttttttaa taaataaata aacataaata     3780

aattgtttgt tgaatttatt attagtatgt aagtgtaaat ataataaaac ttaatatcta     3840

ttcaaattaa taaataaacc tcgatataca gaccgataaa acacatgcgt caattttacg     3900

catgattatc tttaacgtac gtcacaatat gattatcttt ctagggttaa tctagtataa     3960

ttgcttgata agagattgag tatgtttttc ctaaaggtgt taacagggag gctggtgtct     4020

gggtcaggat gatgtcccca tgcactgata aaaagtataa gaagaaagtg tcattgatgg     4080

tgcatggcag ggacatgctc cgtgcagtgg ccaccctcac taagacagat gaactttggg     4140

aaataatacc caatggcaga aaagaaggta gactatgaag gtacccaaaa caagaataag     4200

gtgcacctca tttagtctct gggtattaaa gagacctgca gttcttgata gtggtggatc     4260

tgtgagtgct gcatgcatgg agacaacacg gtatcatctt tgtatatctg taataaattg     4320

cttgatctaa tactagtaag aacaaaggca taacaccatt acctaatact tacaaatata     4380

tagcatcatg ccgatacatt ttatttttaa ttttttttag aaaggaacaa tgttaaactc     4440

acagaaatgt tgcaggtata gcacaattac ccccttccct acccggaatc ttatgagagt     4500

cttttgaaga cttgagaatc ctaccatcta acattttact atgtgtttcc tacaaacaag     4560

aatattctcc taaataatcc tgatacacca atgaaataca ttactctatc ggctcctgag     4620

gaatatttaa aattctcaaa aaaataccta aaaattgttt ctcataataa aatagtcccc     4680

agtagaaaca cattctctgc agacaaattt gtgctaccct ggtcttacct gggacacctg     4740

gggacactga gctggtgctg agttactgag atgagccagc tctgcagctg tgcccagcct     4800

gccccatccc ctgctcattt gcatgttccc agagcacaac ctcctgccct gaagccttat     4860

taataggctg gtcacacttt gtgcaggagt cagacccagt caggacacag catggacatg     4920

agggtccccg ctcagctcct ggggctcctg ctgctctggc tcccaggtaa gtaatttttc     4980

actattgtct tctgaaattt gggtctgatg gccagtattg acttttagag gcttaaatag     5040

gagtttggta aagattggta aatgagggca tttaagattt gccatgggtt gcaaaagtta     5100

aactcagctt caaaaatgga tttggagaaa aaaagattaa attgctctaa actgaatgac     5160

acaaagtaaa aaaaaaaagt gtaactaaaa aggaaccctt gtatttctaa ggagcaaaag     5220

taaatttatt tttgttcact cttgccaaat attgtattgg ttgttgctga ttatgcatga     5280

tacagaaaag tggaaaaata cattttttag tctttctccc ttttgtttga taaattattt     5340

tgtcagacaa caataaaaat caatagcacg ccctaagaaa aatcagggaa aagtgaagtg     5400

tacctatttg ctatgtagaa gaggcagctt acttgaaaat cagcagcaat gttgttttta     5460

gagtctgtaa taagtaataa actcaaaaag acacattcta taggaataag ggcttcacag     5520

atagagctca ttttttaaaa atccaatttg tacattagac taaacgtgaa attatctctt     5580

attgtaatgg tggaaaggtg gttattccca aaagctcaat ctcaaagaaa tgtgtttaaa     5640

tgaaaaaaag taaataattg cattttttaa tgaccgtggg tctgtgaaaa aaataggaaa     5700

tattttaaag agtatgttct ttcattatcc tctgttatta cttgtctaca tttttattct     5760

gccaagaagg ccgtggcacc gcgagctgta gacagagccg cggtctttct cgattgagtg     5820

gctttggtgg ccatgccacc gcgctcttgg ggcagccgcc ttgccgctag tggccgtggc     5880

caccctgtgt ctgcccgatt gatgctgccg tagccagctt tcctgatgca cagtgataca     5940

aataatgcca ctaagggaaa gagaacagaa acgtaatggg cgctgagctg ggaaaaccag     6000

ggagaagact gatttattag agatttcaga aataaaattc acattcatta tgatatctca     6060

ttagtgaaaa tttccattag gggattgtaa ataatttaaa gctttttttt ttttcagtgc     6120

tatttaatta tttcaatatc ctctcatcaa atgtatttaa ataacaaaag ctcaaccaaa     6180

aagaaagaaa tatgtaattc tttcagagta aaaatcacac ccatgacctg gccactgagg     6240

gcttgatcaa ttcactttga atttggcatt aaataccatt aaggtatatt aactgatttt     6300

aaaataagat atattcgtga ccatgttttt aactttcaaa aatgtagctg ccagtgtgtg     6360

attttatttc agttgtacaa aatatctaaa cctatagcaa tgtgattaat aaaaacttaa     6420

acatattttc cagtacctta attctgtgat aggaaaattt taatctgagt attttaattt     6480

cataatctct aaaatagttt aatgatttgt cattgtgttg ctgtcgttta ccccagctga     6540

tctcaaaagt gatatttaag gagattattt tggtctgcaa caacttgata ggactatttt     6600

agggcctttt taaagctcta ttaaaactaa cttacaacga ttcaaaactg ttttaaacta     6660

tttcaaaatg attttagagc cttttgaaaa ctcttttaaa cactttttaa actctattaa     6720

aactaataag ataacttgaa ataattttca tgtcaaatac attaactgtt taatgtttaa     6780

atgccagatg aaaaatgtaa agctatcaag aattcaccca gataggagta tcttcatagc     6840

atgtttttcc ctgcttattt tccagtgatc acattatttt gctaccatgg ttattttata     6900

caattatctg aaaaaaatta gttatgaaga ttaaaagaga agaaaatatt aaacataaga     6960

gattcagtct ttcatgttga actgcttggt taacagtgaa gttagtttta aaaaaaaaaa     7020

aaactatttc tgttatcagc tgacttctcc ctatctgttg acttctccca gcaaaagatt     7080

cttattttac attttaacta ctgctctccc acccaacggg tggaatcccc cagaggggga     7140

tttccaagag gccacctggc agttgctgag ggtcagaagt gaagctagcc acttcctctt     7200

aggcaggtgg ccaagattac agttgacctc tcctggtatg gctgaaaatt gctgcatatg     7260

gttacaggcc ttgaggcctt tgggagggct tagagagttg ctggaacagt cagaaggtgg     7320

aggggctgac accacccagg cgcagaggca gggctcaggg cctgctctgc agggaggttt     7380

tagcccagcc cagccaaagt aacccccggg agcctgttat cccagcacag tcctggaaga     7440

ggcacagggg aaataaaagc ggacggaggc tttccttgac tcagccgctg cctggtcttc     7500

ttcagacctg ttctgaattc taaactctga gggggtcgga tgacgtggcc attctttgcc     7560

taaagcattg agtttactgc aaggtcagaa aagcatgcaa agccctcaga atggctgcaa     7620

agagctccaa caaaacaatt tagaacttta ttaaggaata gggggaagct aggaagaaac     7680

tcaaaacatc aagattttaa atacgcttct tggtctcctt gctataatta tctgggataa     7740

gcatgctgtt ttctgtctgt ccctaacatg ccctgtgatt atccgcaaac aacacaccca     7800

agggcagaac tttgttactt aaacaccatc ctgtttgctt ctttcctcag gtgccaaatg     7860

tgtgtttggc agcgggaccc agctcaccgt tttaagtcag cccaaggcca ccccctcggt     7920

cactctgttc ccgccgtcct ctgaggagct ccaagccaac aaggctacac tggtgtgtct     7980

catgaatgac ttttatccgg gaatcttgac ggtgacctgg aaggcagatg gtacccccat     8040

cacccagggc gtggagatga ccacgccctc caaacagagc aacaacaagt acgcggccag     8100

cagctacctg agcctgacgc ccgagcagtg gaggtcccgc agaagctaca gctgccaggt     8160

catgcacgaa gggagcaccg tggagaagac ggtggcccct gcagaatgtt catagagaca     8220

aaggtcctga gacgccacca ccagctcccc agctccatcc tatcttccct tctaaggtct     8280

tggaggcttc cccacaagcg acctaccact gttgcggtgc tccaaacctc ctccccacct     8340

ccttctcctc ctcctccctt tccttggctt ttatcatgct aatatttgca gaaaatattc     8400

aataaagtga gtctttgcac ttgagatctc tgtctttctt actaaatggt agtaatcagt     8460

tgtttttcca gttacctggg tttctcttct aaagaagtta aatgtttagt tgccctgaaa     8520

tccaccacac ttaaaggata aataaaaccc tccacttgcc ctggttggct gtccactaca     8580

tggcagtcct ttctaaggtt cacgagtact attcatggct tatttctctg ggccatggta     8640

ggtttgagga ggcatacttc ctagttttct tcccctaagt cgtcaaagtc ctgaaggggg     8700

acagtcttta caagcacatg ttctgtaatc tgattcaacc tacccagtaa acttggcgaa     8760

gcaaagtaga atcattatca caggaagcaa aggcaaccta aatgtgcaag caataggaaa     8820

atgtggaagc ccatcatagt acttggactt catctgcttt tgtgccttca ctaagttttt     8880

aaacatgagc tggctcctat ctgccattgg caaggctggg cactacccac aacctacttc     8940

aaggacctct ataccgtgag attacacaca tacatcaaaa tttgggaaaa gttctaccaa     9000

gctgagagct gatcacccca ctcttaggtg cttatctctg tacaccagaa accttaagaa     9060

gcaaccagta ttgagagac                                                  9079


<210>  81
<211>  420
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Lambda 5 transgene-predicted spliced coding sequence

<400>  81
atggacatga gggtccccgc tcagctcctg gggctcctgc tgctctggct cccaggtgcc       60

aaatgtgtgt ttggcagcgg gacccagctc accgttttaa gtcagcccaa ggccaccccc      120

tcggtcactc tgttcccgcc gtcctctgag gagctccaag ccaacaaggc tacactggtg      180

tgtctcatga atgactttta tccgggaatc ttgacggtga cctggaaggc agatggtacc      240

cccatcaccc agggcgtgga gatgaccacg ccctccaaac agagcaacaa caagtacgcg      300

gccagcagct acctgagcct gacgcccgag cagtggaggt cccgcagaag ctacagctgc      360

caggtcatgc acgaagggag caccgtggag aagacggtgg cccctgcaga atgttcatag      420


<210>  82
<211>  139
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Lambda 5 transgene-predicted protein

<400>  82

Met Asp Met Arg Val Pro Ala Gln Leu Leu Gly Leu Leu Leu Leu Trp 
1               5                   10                  15      


Leu Pro Gly Ala Lys Cys Val Phe Gly Ser Gly Thr Gln Leu Thr Val 
            20                  25                  30          


Leu Ser Gln Pro Lys Ala Thr Pro Ser Val Thr Leu Phe Pro Pro Ser 
        35                  40                  45              


Ser Glu Glu Leu Gln Ala Asn Lys Ala Thr Leu Val Cys Leu Met Asn 
    50                  55                  60                  


Asp Phe Tyr Pro Gly Ile Leu Thr Val Thr Trp Lys Ala Asp Gly Thr 
65                  70                  75                  80  


Pro Ile Thr Gln Gly Val Glu Met Thr Thr Pro Ser Lys Gln Ser Asn 
                85                  90                  95      


Asn Lys Tyr Ala Ala Ser Ser Tyr Leu Ser Leu Thr Pro Glu Gln Trp 
            100                 105                 110         


Arg Ser Arg Arg Ser Tyr Ser Cys Gln Val Met His Glu Gly Ser Thr 
        115                 120                 125             


Val Glu Lys Thr Val Ala Pro Ala Glu Cys Ser 
    130                 135                 


<210>  83
<211>  399
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Vk3-2 fragment locus-predicted spliced coding sequence

<400>  83
atggagaaag acacactcct gctatgggtc ctgcttctct gggttccagg ttccacaggt       60

gacattgtgc tgaaacgggc tgatgctgca ccaactgtat ccatcttccc accatccagt      120

gagcagttaa catctggagg tgcctcagtc gtgtgcttct tgaacaactt ctaccccaaa      180

gacatcaatg tcaagtggaa gattgatggc agtgaacgac aaaatggcgt cctgaacagt      240

tggactgatc aggacagcaa agacagcacc tacggcatga gcagcaccct cacgttgacc      300

aaggacgagt atgaacgaca taacagctat acctgtgagg ccactcacaa gacatcaact      360

tcacccattg tcaagagctt caacaggaat gagtgttag                             399


<210>  84
<211>  132
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Vk3-2 fragment locus-predicted protein

<400>  84

Met Glu Lys Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 
1               5                   10                  15      


Gly Ser Thr Gly Asp Ile Val Leu Lys Arg Ala Asp Ala Ala Pro Thr 
            20                  25                  30          


Val Ser Ile Phe Pro Pro Ser Ser Glu Gln Leu Thr Ser Gly Gly Ala 
        35                  40                  45              


Ser Val Val Cys Phe Leu Asn Asn Phe Tyr Pro Lys Asp Ile Asn Val 
    50                  55                  60                  


Lys Trp Lys Ile Asp Gly Ser Glu Arg Gln Asn Gly Val Leu Asn Ser 
65                  70                  75                  80  


Trp Thr Asp Gln Asp Ser Lys Asp Ser Thr Tyr Gly Met Ser Ser Thr 
                85                  90                  95      


Leu Thr Leu Thr Lys Asp Glu Tyr Glu Arg His Asn Ser Tyr Thr Cys 
            100                 105                 110         


Glu Ala Thr His Lys Thr Ser Thr Ser Pro Ile Val Lys Ser Phe Asn 
        115                 120                 125             


Arg Asn Glu Cys 
    130         


<210>  85
<211>  399
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Vk3-4 fragment locus-predicted spliced coding sequence

<400>  85

Ala Thr Gly Gly Ala Gly Ala Cys Ala Gly Ala Cys Ala Cys Ala Ala 
1               5                   10                  15      


Thr Cys Cys Thr Gly Cys Thr Ala Thr Gly Gly Gly Thr Gly Cys Thr 
            20                  25                  30          


Gly Cys Thr Gly Cys Thr Cys Thr Gly Gly Gly Thr Thr Cys Cys Ala 
        35                  40                  45              


Gly Gly Cys Thr Cys Cys Ala Cys Thr Gly Gly Thr Gly Ala Cys Ala 
    50                  55                  60                  


Thr Thr Gly Thr Gly Cys Thr Gly Ala Ala Ala Cys Gly Gly Gly Cys 
65                  70                  75                  80  


Thr Gly Ala Thr Gly Cys Thr Gly Cys Ala Cys Cys Ala Ala Cys Thr 
                85                  90                  95      


Gly Thr Ala Thr Cys Cys Ala Thr Cys Thr Thr Cys Cys Cys Ala Cys 
            100                 105                 110         


Cys Ala Thr Cys Cys Ala Gly Thr Gly Ala Gly Cys Ala Gly Thr Thr 
        115                 120                 125             


Ala Ala Cys Ala Thr Cys Thr Gly Gly Ala Gly Gly Thr Gly Cys Cys 
    130                 135                 140                 


Thr Cys Ala Gly Thr Cys Gly Thr Gly Thr Gly Cys Thr Thr Cys Thr 
145                 150                 155                 160 


Thr Gly Ala Ala Cys Ala Ala Cys Thr Thr Cys Thr Ala Cys Cys Cys 
                165                 170                 175     


Cys Ala Ala Ala Gly Ala Cys Ala Thr Cys Ala Ala Thr Gly Thr Cys 
            180                 185                 190         


Ala Ala Gly Thr Gly Gly Ala Ala Gly Ala Thr Thr Gly Ala Thr Gly 
        195                 200                 205             


Gly Cys Ala Gly Thr Gly Ala Ala Cys Gly Ala Cys Ala Ala Ala Ala 
    210                 215                 220                 


Thr Gly Gly Cys Gly Thr Cys Cys Thr Gly Ala Ala Cys Ala Gly Thr 
225                 230                 235                 240 


Thr Gly Gly Ala Cys Thr Gly Ala Thr Cys Ala Gly Gly Ala Cys Ala 
                245                 250                 255     


Gly Cys Ala Ala Ala Gly Ala Cys Ala Gly Cys Ala Cys Cys Thr Ala 
            260                 265                 270         


Cys Gly Gly Cys Ala Thr Gly Ala Gly Cys Ala Gly Cys Ala Cys Cys 
        275                 280                 285             


Cys Thr Cys Ala Cys Gly Thr Thr Gly Ala Cys Cys Ala Ala Gly Gly 
    290                 295                 300                 


Ala Cys Gly Ala Gly Thr Ala Thr Gly Ala Ala Cys Gly Ala Cys Ala 
305                 310                 315                 320 


Thr Ala Ala Cys Ala Gly Cys Thr Ala Thr Ala Cys Cys Thr Gly Thr 
                325                 330                 335     


Gly Ala Gly Gly Cys Cys Ala Cys Thr Cys Ala Cys Ala Ala Gly Ala 
            340                 345                 350         


Cys Ala Thr Cys Ala Ala Cys Thr Thr Cys Ala Cys Cys Cys Ala Thr 
        355                 360                 365             


Thr Gly Thr Cys Ala Ala Gly Ala Gly Cys Thr Thr Cys Ala Ala Cys 
    370                 375                 380                 


Ala Gly Gly Ala Ala Thr Gly Ala Gly Thr Gly Thr Thr Ala Gly 
385                 390                 395                 


<210>  86
<211>  132
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Vk3-4 fragment locus-predicted protein

<400>  86

Met Glu Thr Asp Thr Ile Leu Leu Trp Val Leu Leu Leu Trp Val Pro 
1               5                   10                  15      


Gly Ser Thr Gly Asp Ile Val Leu Lys Arg Ala Asp Ala Ala Pro Thr 
            20                  25                  30          


Val Ser Ile Phe Pro Pro Ser Ser Glu Gln Leu Thr Ser Gly Gly Ala 
        35                  40                  45              


Ser Val Val Cys Phe Leu Asn Asn Phe Tyr Pro Lys Asp Ile Asn Val 
    50                  55                  60                  


Lys Trp Lys Ile Asp Gly Ser Glu Arg Gln Asn Gly Val Leu Asn Ser 
65                  70                  75                  80  


Trp Thr Asp Gln Asp Ser Lys Asp Ser Thr Tyr Gly Met Ser Ser Thr 
                85                  90                  95      


Leu Thr Leu Thr Lys Asp Glu Tyr Glu Arg His Asn Ser Tyr Thr Cys 
            100                 105                 110         


Glu Ala Thr His Lys Thr Ser Thr Ser Pro Ile Val Lys Ser Phe Asn 
        115                 120                 125             


Arg Asn Glu Cys 
    130         


<210>  87
<211>  399
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Vk6-17 fragment locus-predicted spliced coding sequence

<400>  87
atggagtcac agattcaggt ctttgtattc gtgtttctct ggttgtctgg tgttgacgga       60

gacattgtgc tgaaacgggc tgatgctgca ccaactgtat ccatcttccc accatccagt      120

gagcagttaa catctggagg tgcctcagtc gtgtgcttct tgaacaactt ctaccccaaa      180

gacatcaatg tcaagtggaa gattgatggc agtgaacgac aaaatggcgt cctgaacagt      240

tggactgatc aggacagcaa agacagcacc tacggcatga gcagcaccct cacgttgacc      300

aaggacgagt atgaacgaca taacagctat acctgtgagg ccactcacaa gacatcaact      360

tcacccattg tcaagagctt caacaggaat gagtgttag                             399


<210>  88
<211>  132
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Vk6-17 fragment locus-predicted protein

<400>  88

Met Glu Ser Gln Ile Gln Val Phe Val Phe Val Phe Leu Trp Leu Ser 
1               5                   10                  15      


Gly Val Asp Gly Asp Ile Val Leu Lys Arg Ala Asp Ala Ala Pro Thr 
            20                  25                  30          


Val Ser Ile Phe Pro Pro Ser Ser Glu Gln Leu Thr Ser Gly Gly Ala 
        35                  40                  45              


Ser Val Val Cys Phe Leu Asn Asn Phe Tyr Pro Lys Asp Ile Asn Val 
    50                  55                  60                  


Lys Trp Lys Ile Asp Gly Ser Glu Arg Gln Asn Gly Val Leu Asn Ser 
65                  70                  75                  80  


Trp Thr Asp Gln Asp Ser Lys Asp Ser Thr Tyr Gly Met Ser Ser Thr 
                85                  90                  95      


Leu Thr Leu Thr Lys Asp Glu Tyr Glu Arg His Asn Ser Tyr Thr Cys 
            100                 105                 110         


Glu Ala Thr His Lys Thr Ser Thr Ser Pro Ile Val Lys Ser Phe Asn 
        115                 120                 125             


Arg Asn Glu Cys 
    130         


<210>  89
<211>  399
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Vk10-96 fragment locus-predicted spliced coding sequence

<400>  89
atgatgtcct ctgctcagtt ccttggtctc ctgttgctct gttttcaagg taccagatgt       60

gatatccagc tgaaacgggc tgatgctgca ccaactgtat ccatcttccc accatccagt      120

gagcagttaa catctggagg tgcctcagtc gtgtgcttct tgaacaactt ctaccccaaa      180

gacatcaatg tcaagtggaa gattgatggc agtgaacgac aaaatggcgt cctgaacagt      240

tggactgatc aggacagcaa agacagcacc tacggcatga gcagcaccct cacgttgacc      300

aaggacgagt atgaacgaca taacagctat acctgtgagg ccactcacaa gacatcaact      360

tcacccattg tcaagagctt caacaggaat gagtgttag                             399


<210>  90
<211>  132
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Vk10-96 fragment locus-predicted protein

<400>  90

Met Met Ser Ser Ala Gln Phe Leu Gly Leu Leu Leu Leu Cys Phe Gln 
1               5                   10                  15      


Gly Thr Arg Cys Asp Ile Gln Leu Lys Arg Ala Asp Ala Ala Pro Thr 
            20                  25                  30          


Val Ser Ile Phe Pro Pro Ser Ser Glu Gln Leu Thr Ser Gly Gly Ala 
        35                  40                  45              


Ser Val Val Cys Phe Leu Asn Asn Phe Tyr Pro Lys Asp Ile Asn Val 
    50                  55                  60                  


Lys Trp Lys Ile Asp Gly Ser Glu Arg Gln Asn Gly Val Leu Asn Ser 
65                  70                  75                  80  


Trp Thr Asp Gln Asp Ser Lys Asp Ser Thr Tyr Gly Met Ser Ser Thr 
                85                  90                  95      


Leu Thr Leu Thr Lys Asp Glu Tyr Glu Arg His Asn Ser Tyr Thr Cys 
            100                 105                 110         


Glu Ala Thr His Lys Thr Ser Thr Ser Pro Ile Val Lys Ser Phe Asn 
        115                 120                 125             


Arg Asn Glu Cys 
    130         


<210>  91
<211>  1257
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Vk6-17 full transgene, promoter and leader, including intron and 
       J5 fragment

<400>  91
gggttaggtg catcgatatc tctgaatgaa cacagaccca gcagtactct tctgtatgtg       60

tgttggtggc atcatatcag ctggtgtatg ctgcctgttt ggtgatccag tgtttgagag      120

atctcggggg tccagattaa ttgagacagt tggacttcct acagggtcac tgtcctcctc      180

aacttctttc agtctttccc taattcaaca acaggagtca gctgcttctg tccattggtt      240

gggtgcaaat acctgcatct agctcaactg cttgttgtat cttctagagt gaggtcatgc      300

taggtccctt tctgtgagtt cttcatagcc tcaatgatag tgtcaggcct tgtggctgcc      360

acttgagctg gattccactt tggacctgtc gctggacctt cttttcttca ggctcccctc      420

catttccatc cctgtaattc tttcagacag gaacaattat gggtcagagt tgtaactgta      480

ggatggcacc ccctccctca tttgatgccc tgtcttcctg ctggaggtgg gctctagaag      540

ttccctctcc ctactgttgg gcattttatc cctttgattc ctgagagtct ctcacctgca      600

aggtctctgg tgcattctgg agggtcctcc caacctccta cctcctgagg ttgcctgctt      660

ccattctttc agctggccct cagtgcttca gtcctttacc ctcacccaat atctgatttt      720

gatggaagcc tatcatgaga gcatctatac acttgtggtt tcagagcttt aaattggtcc      780

ttgagcttct attttgactt ccttcccagt gattacttcc tgtctttggt tgtacttttg      840

actgtttatt taacctggat actctcaaac cgctgtgtaa tttacttcct tatttgatga      900

ctcctttgca tagatcccta gaggccagcc cagctgctca tgatttataa accaggtctt      960

tgcagtgaga tatgaaatgc atcacaccag catgggcatc aaaatggagt cacagattca     1020

ggtctttgta ttcgtgtttc tctggttgtc tggtgagaca tgtaaaactt ttataatatc     1080

ttaaaagtaa ttcatttaaa tatctatttc ctataagaag ccaatattag gcagacaatg     1140

ctattagata agacattttg gattctaaca tttgtatcat gaagtctttg tatgtgtaag     1200

tgtatacaca ttatctgttt ctgtttgcag gtgttgacgg agacattgtg ctgaaac        1257


<210>  92
<211>  3177
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Vk6-17 full targeting vector insert including homology arms

<400>  92
gctgaatctt gaatgacagc tcaagggata gggaggacag ggtgttcaga agcagagaag       60

atgccttgta aatgtggaag gctgtggcag gattggaagg actttggggt ggtaggaagg      120

ggatgggaat gggtggttac aagagaaaca agactgtagt aaataaagct gaaactcaaa      180

gcaagctttc agcatcttta attggagaca caaacttcaa aggtatcatg aatgtggttg      240

atcttggtga aagttgagct tcacctgtcc taacaacaga ccaatccatg agtgaaagct      300

tatctttctc ctttattaat ggttgctgtt gtatccataa ctcaattcca aaggatatga      360

accttaacat atagatataa ttttgtgtac cttctatgaa acagcattaa agcaaagaag      420

ttcaaataga aagactggct tagttattat taactaagag atgctagtga gttctaaatt      480

aataccattt aaaatttata atttgcagaa ttaccaccac caccaccact cagcccagga      540

aaagttacaa agaactggct atccaatttg tttgttttcc tcctttttag agttctttta      600

tttatgtgtg agtgaatgcc atgtacttat ggatgcagag gctgtcagat tccttgcagc      660

tggagtaata gacagttgtg agctacttat agtactagaa ctaagatcct atggaagagc      720

agcgagtgcc actaactgct gagccacctc tccagcccat ttctttattt ttcaatgaac      780

aaataataag cagtcctatg tgacatgctt ctaaagcaaa agatataata tttagtatta      840

tatacattaa taataaaata cattatcttc taagaattga agtctcaact atgaaaatca      900

gcagttctct gtcagagaag gggttaggtg catcgatatc tctgaatgaa cacagaccca      960

gcagtactct tctgtatgtg tgttggtggc atcatatcag ctggtgtatg ctgcctgttt     1020

ggtgatccag tgtttgagag atctcggggg tccagattaa ttgagacagt tggacttcct     1080

acagggtcac tgtcctcctc aacttctttc agtctttccc taattcaaca acaggagtca     1140

gctgcttctg tccattggtt gggtgcaaat acctgcatct agctcaactg cttgttgtat     1200

cttctagagt gaggtcatgc taggtccctt tctgtgagtt cttcatagcc tcaatgatag     1260

tgtcaggcct tgtggctgcc acttgagctg gattccactt tggacctgtc gctggacctt     1320

cttttcttca ggctcccctc catttccatc cctgtaattc tttcagacag gaacaattat     1380

gggtcagagt tgtaactgta ggatggcacc ccctccctca tttgatgccc tgtcttcctg     1440

ctggaggtgg gctctagaag ttccctctcc ctactgttgg gcattttatc cctttgattc     1500

ctgagagtct ctcacctgca aggtctctgg tgcattctgg agggtcctcc caacctccta     1560

cctcctgagg ttgcctgctt ccattctttc agctggccct cagtgcttca gtcctttacc     1620

ctcacccaat atctgatttt gatggaagcc tatcatgaga gcatctatac acttgtggtt     1680

tcagagcttt aaattggtcc ttgagcttct attttgactt ccttcccagt gattacttcc     1740

tgtctttggt tgtacttttg actgtttatt taacctggat actctcaaac cgctgtgtaa     1800

tttacttcct tatttgatga ctcctttgca tagatcccta gaggccagcc cagctgctca     1860

tgatttataa accaggtctt tgcagtgaga tatgaaatgc atcacaccag catgggcatc     1920

aaaatggagt cacagattca ggtctttgta ttcgtgtttc tctggttgtc tggtgagaca     1980

tgtaaaactt ttataatatc ttaaaagtaa ttcatttaaa tatctatttc ctataagaag     2040

ccaatattag gcagacaatg ctattagata agacattttg gattctaaca tttgtatcat     2100

gaagtctttg tatgtgtaag tgtatacaca ttatctgttt ctgtttgcag gtgttgacgg     2160

agacattgtg ctgaaacgta agtacacttt tctcatcttt ttttatgtgt aagacacagg     2220

ttttcatgtt aggagttaaa gtcagttcag aaaatcttga gaaaatggag agggctcatt     2280

atcagttgac gtggcataca gtgtcagatt ttctgtttat caagctagtg agattagggg     2340

caaaaagagg ctttagttga gaggaaagta attaatacta tggtcaccat ccaagagatt     2400

ggatcggaga ataagcatga gtagttattg agatctgggt ctgactgcag gtagcgtggt     2460

cttctagacg tttaagtggg agatttggag gggatgagga atgaaggaac ttcaggatag     2520

aaaagggctg aagtcaagtt cagctcctaa aatggatgtg ggagcaaact ttgaagataa     2580

actgaatgac ccagaggatg aaacagcgca gatcaaagag gggcctggag ctctgagaag     2640

agaaggagac tcatccgtgt tgagtttcca caagtactgt cttgagtttt gcaataaaag     2700

tgggatagca gagttgagtg agccgtaggc tgagttctct cttttgtctc ctaagttttt     2760

atgactacaa aaatcagtag tatgtcctga aataatcatt aagctgtttg aaagtatgac     2820

tgcttgccat gtagatacca tggcttgctg aataatcaga agaggtgtga ctcttattct     2880

aaaatttgtc acaaaatgtc aaaatgagag actctgtagg aacgagtcct tgacagacag     2940

ctcaaggggt ttttttcctt tgtctcattt ctacatgaaa gtaaatttga aatgatcttt     3000

tttattataa gagtagaaat acagttgggt ttgaactata tgttttaatg gccacggttt     3060

tgtaagacat ttggtccttt gttttcccag ttattactcg attgtaattt tatatcgcca     3120

gcaatggact gaaacggtcc gcaacctctt ctttacaact gggtgacctc gcggctg        3177


<210>  93
<211>  1199
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Vk10-96 full transgene, promoter and leader, including intron and
       J5 fragment

<400>  93
acagtgggta atagtctctg gcaggacagc gctgatgatc atgagggctt cctctcagca       60

attaaagact acaatgggaa catatccata acacagtgat cagtgttgac tggtatacta      120

gggatgtcct tttacactgt gcttaatttt gttgggattc attatttatc caatcgtagg      180

aaccaaatgt aacatccaga gtacccagta gcagtgtttt ctgttatagt attcaaggat      240

atcttcacta gtcaaacgtg tatgctgaag aattgtggta aatattagca agtacaagaa      300

aagtgtttaa gtagatgatc ccaaactgag caaagggtac atcccattat tcccaagaga      360

ataaatatac tttcatattc atgtggacaa agaattcctt gtgatatagg ttgctgggat      420

caggaattat atgtgcccat attttgcatt tactcattat actgtattaa acacggctaa      480

ttctgttaaa tcttactttt taattcacca aaaagagtcc tgataaatta tactcttaat      540

taaaagacat gattactcta atcacacaaa tggttcacaa ggataatatg tagtatttta      600

aaagcaattg aattattaat ctgattaata atctcctgtt tgaataatat tcctagaaac      660

aagattgttt tttatattac acccaatgta tatttgatat atagtattac aattagagct      720

catgtatagt agaatttttc aaataacctt caaaatgaca tctgtaattt taaaacctta      780

aaaatgaagt gtgatctcca aagccatatg ttcactctga ccttgggcaa agaggggtca      840

ctgtgcttgt gctaagtcct gagaagagtt agccttgcag ctgtgctcag ccctaaatag      900

ttcccaaaaa tttgcatgct ctcacttcct atctttgggt actttttcat ataccagtca      960

gattgtgagc cattgtaatt gaagtcaaga ctcagcctgg acatgatgtc ctctgctcag     1020

ttccttggtc tcctgttgct ctgttttcaa ggtaaaattt actacaatgg gaattttgct     1080

gttgcacagt gattcttgtt gactggaatt ttggaggggt cctttctttt cctgcttaac     1140

tctgtgggta tttattatgt ctccactcct aggtaccaga tgtgatatcc agctgaaac      1199


<210>  94
<211>  3119
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Vk10-96 full targeting vector insert including homology arms

<400>  94
gctgaatctt gaatgacagc tcaagggata gggaggacag ggtgttcaga agcagagaag       60

atgccttgta aatgtggaag gctgtggcag gattggaagg actttggggt ggtaggaagg      120

ggatgggaat gggtggttac aagagaaaca agactgtagt aaataaagct gaaactcaaa      180

gcaagctttc agcatcttta attggagaca caaacttcaa aggtatcatg aatgtggttg      240

atcttggtga aagttgagct tcacctgtcc taacaacaga ccaatccatg agtgaaagct      300

tatctttctc ctttattaat ggttgctgtt gtatccataa ctcaattcca aaggatatga      360

accttaacat atagatataa ttttgtgtac cttctatgaa acagcattaa agcaaagaag      420

ttcaaataga aagactggct tagttattat taactaagag atgctagtga gttctaaatt      480

aataccattt aaaatttata atttgcagaa ttaccaccac caccaccact cagcccagga      540

aaagttacaa agaactggct atccaatttg tttgttttcc tcctttttag agttctttta      600

tttatgtgtg agtgaatgcc atgtacttat ggatgcagag gctgtcagat tccttgcagc      660

tggagtaata gacagttgtg agctacttat agtactagaa ctaagatcct atggaagagc      720

agcgagtgcc actaactgct gagccacctc tccagcccat ttctttattt ttcaatgaac      780

aaataataag cagtcctatg tgacatgctt ctaaagcaaa agatataata tttagtatta      840

tatacattaa taataaaata cattatcttc taagaattga agtctcaact atgaaaatca      900

gcagttctct gtcagagaag acagtgggta atagtctctg gcaggacagc gctgatgatc      960

atgagggctt cctctcagca attaaagact acaatgggaa catatccata acacagtgat     1020

cagtgttgac tggtatacta gggatgtcct tttacactgt gcttaatttt gttgggattc     1080

attatttatc caatcgtagg aaccaaatgt aacatccaga gtacccagta gcagtgtttt     1140

ctgttatagt attcaaggat atcttcacta gtcaaacgtg tatgctgaag aattgtggta     1200

aatattagca agtacaagaa aagtgtttaa gtagatgatc ccaaactgag caaagggtac     1260

atcccattat tcccaagaga ataaatatac tttcatattc atgtggacaa agaattcctt     1320

gtgatatagg ttgctgggat caggaattat atgtgcccat attttgcatt tactcattat     1380

actgtattaa acacggctaa ttctgttaaa tcttactttt taattcacca aaaagagtcc     1440

tgataaatta tactcttaat taaaagacat gattactcta atcacacaaa tggttcacaa     1500

ggataatatg tagtatttta aaagcaattg aattattaat ctgattaata atctcctgtt     1560

tgaataatat tcctagaaac aagattgttt tttatattac acccaatgta tatttgatat     1620

atagtattac aattagagct catgtatagt agaatttttc aaataacctt caaaatgaca     1680

tctgtaattt taaaacctta aaaatgaagt gtgatctcca aagccatatg ttcactctga     1740

ccttgggcaa agaggggtca ctgtgcttgt gctaagtcct gagaagagtt agccttgcag     1800

ctgtgctcag ccctaaatag ttcccaaaaa tttgcatgct ctcacttcct atctttgggt     1860

actttttcat ataccagtca gattgtgagc cattgtaatt gaagtcaaga ctcagcctgg     1920

acatgatgtc ctctgctcag ttccttggtc tcctgttgct ctgttttcaa ggtaaaattt     1980

actacaatgg gaattttgct gttgcacagt gattcttgtt gactggaatt ttggaggggt     2040

cctttctttt cctgcttaac tctgtgggta tttattatgt ctccactcct aggtaccaga     2100

tgtgatatcc agctgaaacg taagtacact tttctcatct ttttttatgt gtaagacaca     2160

ggttttcatg ttaggagtta aagtcagttc agaaaatctt gagaaaatgg agagggctca     2220

ttatcagttg acgtggcata cagtgtcaga ttttctgttt atcaagctag tgagattagg     2280

ggcaaaaaga ggctttagtt gagaggaaag taattaatac tatggtcacc atccaagaga     2340

ttggatcgga gaataagcat gagtagttat tgagatctgg gtctgactgc aggtagcgtg     2400

gtcttctaga cgtttaagtg ggagatttgg aggggatgag gaatgaagga acttcaggat     2460

agaaaagggc tgaagtcaag ttcagctcct aaaatggatg tgggagcaaa ctttgaagat     2520

aaactgaatg acccagagga tgaaacagcg cagatcaaag aggggcctgg agctctgaga     2580

agagaaggag actcatccgt gttgagtttc cacaagtact gtcttgagtt ttgcaataaa     2640

agtgggatag cagagttgag tgagccgtag gctgagttct ctcttttgtc tcctaagttt     2700

ttatgactac aaaaatcagt agtatgtcct gaaataatca ttaagctgtt tgaaagtatg     2760

actgcttgcc atgtagatac catggcttgc tgaataatca gaagaggtgt gactcttatt     2820

ctaaaatttg tcacaaaatg tcaaaatgag agactctgta ggaacgagtc cttgacagac     2880

agctcaaggg gtttttttcc tttgtctcat ttctacatga aagtaaattt gaaatgatct     2940

tttttattat aagagtagaa atacagttgg gtttgaacta tatgttttaa tggccacggt     3000

tttgtaagac atttggtcct ttgttttccc agttattact cgattgtaat tttatatcgc     3060

cagcaatgga ctgaaacggt ccgcaacctc ttctttacaa ctgggtgacc tcgcggctg      3119


<210>  95
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer HCP428

<400>  95
gctctggctc ccaggaactg                                                   20


<210>  96
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer HCP431

<400>  96
gtcctgctct gtgacactct                                                   20


<210>  97
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer HCP446

<400>  97
tttgtgcagg agtcagaccc ag                                                22


<210>  98
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer HCP451

<400>  98
aaaagggtca gaggccaaag gat                                               23


<210>  99
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer HCP428

<400>  99
gctctggctc ccaggaactg                                                   20


<210>  100
<211>  354
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Mouse lambda 5 gene fragment, truncated to include just the 
       J-segment-like and C-segment-like domains

<400>  100
gtctttggtg gtgggaccca gctcacaatc ctaggtcagc ccaagtctga ccccttggtc       60

actctgttcc tgccttcctt aaagaatctt cagccaacaa ggccacacgt agtgtgtttg      120

gtgagcgaat tctacccagg tactttggtg gtggactgga aggtagatgg ggtccctgtc      180

actcagggtg tagagacaac ccaaccctcc aaacagacca acaacaaata catggtcagc      240

agctacctga cactgatatc tgaccagtgg atgcctcaca gtagatacag ctgccgggtc      300

actcatgaag gaaacactgt ggagaagagt gtgtcacctg ctgagtgttc ttag            354


<210>  101
<211>  117
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mouse lambda 5 gene fragment, truncated to include just the 
       J-segment-like and C-segment-like domains-translated

<400>  101

Val Phe Gly Gly Gly Thr Gln Leu Thr Ile Leu Gly Gln Pro Lys Ser 
1               5                   10                  15      


Asp Pro Leu Val Thr Leu Phe Leu Pro Ser Leu Lys Asn Leu Gln Ala 
            20                  25                  30          


Asn Lys Ala Thr Leu Val Cys Leu Val Ser Glu Phe Tyr Pro Gly Thr 
        35                  40                  45              


Leu Val Val Asp Trp Lys Val Asp Gly Val Pro Val Thr Gln Gly Val 
    50                  55                  60                  


Glu Thr Thr Gln Pro Ser Lys Gln Thr Asn Asn Lys Tyr Met Val Ser 
65                  70                  75                  80  


Ser Tyr Leu Thr Leu Ile Ser Asp Gln Trp Met Pro His Ser Arg Tyr 
                85                  90                  95      


Ser Cys Arg Val Thr His Glu Gly Asn Thr Val Glu Lys Ser Val Ser 
            100                 105                 110         


Pro Ala Glu Cys Ser 
        115         


