               SEQUENCE LISTING

<110> Valerie, Nicholas Carl Kristoffer
      Page, Brent David George
      Altun, Mikael

<120> Methods

<130> KARBX/P70156PC

<140> PCT/EP2019/073769
<141> 2019-09-05

<150> GB - 1814451.9 
<151> 2018-09-05

<160> 648

<170> BiSSAP 1.3.6

<210> 1
<211> 9
<212> PRT
<213> Artificial Sequence


<220> 
<223> Destabilising domain - Tau; E3 ligase (Keap1)

<400> 1
Leu Asp Pro Glu Thr Gly Glu Tyr Leu 
1               5                   

<210> 2
<211> 10
<212> PRT
<213> Artificial Sequence


<220> 
<223> Destabilising domain - I?B?; E3 ligase (SCF?-TRCP)

<400> 2
Asp Arg His Asp Ser Gly Leu Asp Ser Met 
1               5                   10  

<210> 3
<211> 13
<212> PRT
<213> Artificial Sequence


<220> 
<223> Destabilising domain - Mineral corticoid receptor; E3 ligase
      (CHIP)

<400> 3
Gly Gly Ala Arg Lys Ser Lys Lys Leu Gly Lys Leu Lys 
1               5                   10              

<210> 4
<211> 23
<212> PRT
<213> Artificial Sequence


<220> 
<223> Destabilising domain - HIF-1?; E3 ligase (VHL)

<400> 4
Ala Ser Ala Asp Leu Asp Leu Glu Ala Leu Ala Pro Tyr Ile Pro Ala 
1               5                   10                  15      
Asp Asp Asp Phe Gln Leu Arg 
            20              

<210> 5
<211> 22
<212> PRT
<213> Artificial Sequence


<220> 
<223> Destabilising domain - Cyclin D1; E3 ligase (SCFFBX4)

<400> 5
Lys Ala Ala Glu Glu Glu Glu Val Ser Leu Ala Ser Thr Pro Thr Asp 
1               5                   10                  15      
Val Arg Asp Val Asp Ile 
            20          

<210> 6
<211> 22
<212> PRT
<213> Artificial Sequence


<220> 
<223> Destabilising domain - p53; E3 ligase (MDM2)

<400> 6
Lys Pro Leu Ser Ser Ser Val Pro Ser Gln Lys Thr Tyr Gln Gly Ser 
1               5                   10                  15      
Tyr Gly Phe Arg Leu Gly 
            20          

<210> 7
<211> 22
<212> PRT
<213> Artificial Sequence


<220> 
<223> Destabilising domain - ?-catenin; E3 ligase (SCF?-TRCP)

<400> 7
Lys Ala Trp Gln Gln Gln Ser Tyr Leu Asp Ser Gly Ile His Ser Gly 
1               5                   10                  15      
Ala Thr Thr Thr Ala Pro 
            20          

<210> 8
<211> 25
<212> PRT
<213> Artificial Sequence


<220> 
<223> Destabilising domain - TAZ; E3 ligase (SCF?-TRCP)

<400> 8
Lys Pro Phe Leu Asn Gly Gly Pro Tyr His Ser Arg Glu Gln Ser Thr 
1               5                   10                  15      
Asp Ser Gly Leu Gly Leu Gly Ser Tyr 
            20                  25  

<210> 9
<211> 13
<212> PRT
<213> Artificial Sequence


<220> 
<223> Destabilising domain - iNOS

<400> 9
Lys Glu Glu Lys Asp Ile Asn Asn Asn Val Lys Lys Thr 
1               5                   10              

<210> 10
<211> 16
<212> PRT
<213> Artificial Sequence


<220> 
<223> Destabilising domain - SRC3; E3 ligase (SPOP)

<400> 10
Asp Val Gln Lys Ala Asp Val Ser Ser Thr Gly Gln Gly Ile Asp Ser 
1               5                   10                  15      



<210> 11
<211> 16
<212> PRT
<213> Artificial Sequence


<220> 
<223> Destabilising domain - IFNAR1; E3 ligase (SCF?-TRCP)

<400> 11
Lys Lys Tyr Ser Ser Gln Thr Ser Gln Asp Ser Gly Asn Tyr Ser Asn 
1               5                   10                  15      



<210> 12
<211> 20
<212> PRT
<213> Artificial Sequence


<220> 
<223> Destabilising domain - Bonger

<400> 12
Lys Thr Arg Gly Val Glu Glu Val Ala Glu Gly Val Val Leu Leu Arg 
1               5                   10                  15      
Arg Arg Gly Asn 
            20  

<210> 13
<211> 14
<212> PRT
<213> Artificial Sequence


<220> 
<223> Destabilising domain - RNaseA, hsc70, hemoglobin; microautophagy

<400> 13
Lys Phe Glu Arg Gln Lys Ile Leu Asp Gln Arg Phe Phe Glu 
1               5                   10                  

<210> 14
<211> 6
<212> PRT
<213> Artificial Sequence


<220> 
<223> Minimum sequence - HIF-1?; E3 ligase (VHL)

<400> 14
Leu Ala Pro Tyr Ile Pro 
1               5       

<210> 15
<211> 7
<212> PRT
<213> Artificial Sequence


<220> 
<223> Minimum sequence - ?-catenin; E3 ligase (SCF?-TRCP)

<400> 15
Asp Ser Gly Ile His Ser Gly 
1               5           

<210> 16
<211> 10
<212> PRT
<213> Artificial Sequence


<220> 
<223> Minimum sequence - TAZ; E3 ligase (SCF?-TRCP)

<400> 16
His Ser Arg Glu Gln Ser Thr Asp Ser Gly 
1               5                   10  

<210> 17
<211> 5
<212> PRT
<213> Artificial Sequence


<220> 
<223> Minimum sequence - iNOS

<400> 17
Asp Ile Asn Asn Asn 
1               5   

<210> 18
<211> 10
<212> PRT
<213> Artificial Sequence


<220> 
<223> Minimum sequence - SRC3; E3 ligase (SPOP)

<400> 18
Asp Val Gln Lys Ala Asp Val Ser Ser Thr 
1               5                   10  

<210> 19
<211> 6
<212> PRT
<213> Artificial Sequence


<220> 
<223> Minimum sequence - IFNAR1; E3 ligase (SCF?-TRCP)

<400> 19
Asp Ser Gly Asn Tyr Ser 
1               5       

<210> 20
<211> 6
<212> PRT
<213> Artificial Sequence


<220> 
<223> Destabilising motif

<220> 
<221> VARIANT
<222> 4,5
<223> Any amino acid

<400> 20
Asp Ser Gly Xaa Xaa Ser 
1               5       

<210> 21
<211> 5
<212> PRT
<213> Artificial Sequence


<220> 
<223> Destabilising motif

<220> 
<221> VARIANT
<222> 4
<223> Any amino acid

<400> 21
Thr Pro Pro Xaa Ser 
1               5   

<210> 22
<211> 23
<212> PRT
<213> Artificial Sequence


<220> 
<223> C-terminal degron sequence for nMyc

<400> 22
Leu Glu Lys Glu Lys Leu Gln Ala Arg Gln Gln Gln Leu Leu Lys Lys 
1               5                   10                  15      
Ile Glu His Ala Arg Thr Cys 
            20              

<210> 23
<211> 23
<212> PRT
<213> Artificial Sequence


<220> 
<223> C-terminal degron targeted by the CRL2 complex

<400> 23
Gly Trp Thr Ile Asp Met Arg Arg Asn Glu Pro Glu Arg Thr Arg Ser 
1               5                   10                  15      
Leu Ser Ala Pro Gly Pro Leu 
            20              

<210> 24
<211> 23
<212> PRT
<213> Artificial Sequence


<220> 
<223> C-terminal degron targeted by the CRL2 complex

<400> 24
Lys Asn Asn Arg Tyr Ser Gly Trp Pro Ala Glu Ile Gln Ile Glu Gly 
1               5                   10                  15      
Cys Ile Pro Lys Glu Arg Ser 
            20              

<210> 25
<211> 23
<212> PRT
<213> Artificial Sequence


<220> 
<223> C-terminal degron targeted by the CRL2 complex

<400> 25
Leu Lys Glu Ser Trp Val Thr Asp Ser Ile Asp Lys Cys Glu Leu Gln 
1               5                   10                  15      
Glu Glu Asn Gln Tyr Leu Ile 
            20              

<210> 26
<211> 23
<212> PRT
<213> Artificial Sequence


<220> 
<223> C-terminal degron targeted by the CRL2 complex

<400> 26
Met Pro Ala Ser Ser Trp Thr Asp His Lys Glu Ala Leu Glu Arg Gly 
1               5                   10                  15      
Gln Phe Asp Tyr Ala Leu Val 
            20              

<210> 27
<211> 23
<212> PRT
<213> Artificial Sequence


<220> 
<223> C-terminal degron targeted by the CRL2 complex

<400> 27
Tyr Trp Trp Leu Arg Met Gln Ile Met Thr His Leu Pro Gly Ala Ile 
1               5                   10                  15      
Ser Asp Met Ile Tyr Ile Arg 
            20              

<210> 28
<211> 23
<212> PRT
<213> Artificial Sequence


<220> 
<223> C-terminal degron targeted by the CRL2 complex

<400> 28
Asn Phe Gln Glu Arg Val Phe Pro Leu Phe Ser Val Cys Ser Thr Gly 
1               5                   10                  15      
Thr Tyr Leu Arg Ile Trp Pro 
            20              

<210> 29
<211> 23
<212> PRT
<213> Artificial Sequence


<220> 
<223> C-terminal degron targeted by the CRL2 complex

<400> 29
Pro Glu Lys Arg Pro Thr Phe Gln Gln Leu Leu Ser Ser Ile Glu Pro 
1               5                   10                  15      
Leu Arg Glu Lys Asp Lys His 
            20              

<210> 30
<211> 23
<212> PRT
<213> Artificial Sequence


<220> 
<223> C-terminal degron targeted by the CRL2 complex

<400> 30
Ser Cys Cys Ala Pro Thr Ser Ser Cys Gln Pro Ser Cys Cys Arg Pro 
1               5                   10                  15      
Ala Ser Cys Val Ser Leu Leu 
            20              

<210> 31
<211> 23
<212> PRT
<213> Artificial Sequence


<220> 
<223> C-terminal degron targeted by the CRL2 complex

<400> 31
Lys Gln Gly His Tyr Leu Pro Leu Asn Glu Ala Val Tyr Thr Arg Ile 
1               5                   10                  15      
Cys Ser Gly Ala Phe Ala Leu 
            20              

<210> 32
<211> 23
<212> PRT
<213> Artificial Sequence


<220> 
<223> C-terminal degron targeted by the CRL2 complex

<400> 32
Phe Ser Leu Val Ala Arg Arg Arg Trp Glu Arg Glu Cys Ser Pro Trp 
1               5                   10                  15      
Gly Pro Pro Pro Phe Pro Phe 
            20              

<210> 33
<211> 23
<212> PRT
<213> Artificial Sequence


<220> 
<223> C-terminal degron targeted by the CRL2 complex

<400> 33
Thr Lys Ile Thr Cys Glu Glu Lys Met Val Ser Met Ala Arg Asn Thr 
1               5                   10                  15      
Tyr Gly Glu Ser Lys Gly Arg 
            20              

<210> 34
<211> 23
<212> PRT
<213> Artificial Sequence


<220> 
<223> C-terminal degron targeted by the CRL2 complex

<400> 34
Gly Lys Gln Pro Val Ser Leu Pro Ala Arg Arg Leu Lys Leu Arg Gly 
1               5                   10                  15      
Arg Lys Arg Arg Gln Arg Gly 
            20              

<210> 35
<211> 23
<212> PRT
<213> Artificial Sequence


<220> 
<223> C-terminal degron targeted by the CRL2 complex

<400> 35
Asp Gly Phe Val Asn Glu Ser Arg Leu Gln Lys Ile Val Ser Val Ile 
1               5                   10                  15      
Asp Glu Glu Ile Lys Lys Arg 
            20              

<210> 36
<211> 23
<212> PRT
<213> Artificial Sequence


<220> 
<223> C-terminal degron targeted by the CRL2 complex

<400> 36
Asn Trp Leu Ser Glu Glu Asn Val Lys Ile Ile Glu Asn His Phe Thr 
1               5                   10                  15      
Thr Tyr Glu Val Thr Met Ile 
            20              

<210> 37
<211> 23
<212> PRT
<213> Artificial Sequence


<220> 
<223> C-terminal degron targeted by the CRL2 complex

<400> 37
Tyr Gly Gly Tyr Arg Tyr Ser Cys Cys His Pro Ser Cys Tyr Gly Gly 
1               5                   10                  15      
Tyr Trp Ser Ser Gly Phe Tyr 
            20              

<210> 38
<211> 23
<212> PRT
<213> Artificial Sequence


<220> 
<223> C-terminal degron targeted by the CRL2 complex

<400> 38
Lys Phe Ala Asp His Leu His Lys Phe His Glu Asn Asp Asn Gly Ala 
1               5                   10                  15      
Ala Ala Gly Asp Leu Trp Gln 
            20              

<210> 39
<211> 23
<212> PRT
<213> Artificial Sequence


<220> 
<223> C-terminal degron targeted by the CRL2 complex

<400> 39
Val Ser Ser Leu Ser Ser Val Thr Leu Pro Leu Thr Ile Ser Ser Gly 
1               5                   10                  15      
His Lys Ser Arg Pro His Phe 
            20              

<210> 40
<211> 23
<212> PRT
<213> Artificial Sequence


<220> 
<223> C-terminal degron targeted by the CRL2 complex

<400> 40
Ile Phe Asn Pro Ala Lys Glu Leu Met Ala Lys Leu Gln Lys Leu Gln 
1               5                   10                  15      
Ala Ala Glu Gly Lys Lys Arg 
            20              

<210> 41
<211> 23
<212> PRT
<213> Artificial Sequence


<220> 
<223> C-terminal degron targeted by the CRL2 complex

<400> 41
Phe Lys Glu Glu Gln Gln Lys Leu Tyr Ser Lys Met Ile Val Gly Asn 
1               5                   10                  15      
His Lys Asp Arg Ser Arg Ser 
            20              

<210> 42
<211> 23
<212> PRT
<213> Artificial Sequence


<220> 
<223> C-terminal degron targeted by the CRL2 complex

<400> 42
Arg Lys Gly Gly Lys Asp Val Phe Gln Val Asp Ile Pro Glu His Leu 
1               5                   10                  15      
Ile Pro Leu Gly His Glu Val 
            20              

<210> 43
<211> 23
<212> PRT
<213> Artificial Sequence


<220> 
<223> C-terminal degron targeted by the CRL2 complex

<400> 43
Thr Ser Asn Ala Cys Thr Leu Ser Ala Ile Ser Thr Ile Met Ile Ser 
1               5                   10                  15      
Leu Thr Ala Arg Ser Ser Leu 
            20              

<210> 44
<211> 23
<212> PRT
<213> Artificial Sequence


<220> 
<223> C-terminal degron targeted by the CRL2 complex

<400> 44
Tyr Leu Val Ala Trp Gln Pro Val Val Ile Gly Ile Val Gln Gly Ile 
1               5                   10                  15      
Asn Tyr Ser Leu Gly Leu Glu 
            20              

<210> 45
<211> 23
<212> PRT
<213> Artificial Sequence


<220> 
<223> C-terminal degron targeted by the CRL2 complex

<400> 45
Arg Ser Cys Val Phe Arg Ser Thr Val Gln Arg Phe Pro Thr Thr Tyr 
1               5                   10                  15      
Phe Ile Pro Val Ser Ile Met 
            20              

<210> 46
<211> 23
<212> PRT
<213> Artificial Sequence


<220> 
<223> C-terminal degron targeted by the CRL2 complex

<400> 46
Thr Lys Val Leu Gln Leu Glu Cys Lys Tyr Ile Thr Val Asn Ile Ser 
1               5                   10                  15      
Tyr Val Asn Ile Phe Arg Met 
            20              

<210> 47
<211> 23
<212> PRT
<213> Artificial Sequence


<220> 
<223> C-terminal degron targeted by the CRL2 complex

<400> 47
Arg Pro Pro Arg Pro Ala Phe Phe Pro Gln Pro Pro His Ser Glu Gly 
1               5                   10                  15      
Arg Met Ser Phe His Gln Gly 
            20              

<210> 48
<211> 23
<212> PRT
<213> Artificial Sequence


<220> 
<223> C-terminal degron targeted by the CRL2 complex

<400> 48
Val Leu Val Ala Leu Arg Asp Ile Asn Gln Gly Glu Glu Leu Phe Ser 
1               5                   10                  15      
Asn Tyr Tyr Thr Ile Val Ser 
            20              

<210> 49
<211> 23
<212> PRT
<213> Artificial Sequence


<220> 
<223> C-terminal degron targeted by the CRL2 complex

<400> 49
Lys Lys His Ser Leu Asp Leu Leu Ser Lys Glu Arg Glu Leu Asn Gly 
1               5                   10                  15      
Lys Leu Arg His Leu Ser Pro 
            20              

<210> 50
<211> 23
<212> PRT
<213> Artificial Sequence


<220> 
<223> C-terminal degron targeted by the CRL2 complex

<400> 50
Ile Pro Phe Ser Lys Thr Tyr Ser Lys Ser Glu Lys Ile Tyr Pro Glu 
1               5                   10                  15      
Pro Arg Arg Asn Gly Ser Lys 
            20              

<210> 51
<211> 23
<212> PRT
<213> Artificial Sequence


<220> 
<223> C-terminal degron targeted by the CRL2 complex

<400> 51
Lys Ile Arg Leu Leu Leu Arg Lys His Arg Ala Ala Phe Ser Val Leu 
1               5                   10                  15      
Ser Leu Gly Ala His Ser Val 
            20              

<210> 52
<211> 23
<212> PRT
<213> Artificial Sequence


<220> 
<223> C-terminal degron targeted by the CRL2 complex

<400> 52
Lys Pro Asn Pro Gly Leu Ser Lys Asp Ile Thr His Phe Leu Leu Gln 
1               5                   10                  15      
Gln Asn Val Met Lys Asp Leu 
            20              

<210> 53
<211> 23
<212> PRT
<213> Artificial Sequence


<220> 
<223> C-terminal degron targeted by the CRL2 complex

<400> 53
Arg His His Gly Ala Ala Ala Leu Lys Tyr Leu Pro Ala Leu Gln Gln 
1               5                   10                  15      
Pro Gln Ser Pro Ala Arg Gly 
            20              

<210> 54
<211> 23
<212> PRT
<213> Artificial Sequence


<220> 
<223> C-terminal degron targeted by the CRL2 complex

<400> 54
Ser Ile Pro Phe Leu Ser Pro Asn Cys Pro Asn Gln Glu Gly Asn Asp 
1               5                   10                  15      
Ile Ser Ala Ala Leu Ala Thr 
            20              

<210> 55
<211> 23
<212> PRT
<213> Artificial Sequence


<220> 
<223> C-terminal degron targeted by the CRL2 complex

<400> 55
Asp Cys Ser Gly Lys Lys Arg Cys Cys His Ser Ala Cys Gly Arg Asp 
1               5                   10                  15      
Cys Arg Asp Pro Ala Arg Gly 
            20              

<210> 56
<211> 23
<212> PRT
<213> Artificial Sequence


<220> 
<223> C-terminal degron targeted by the CRL2 complex

<400> 56
Ser Ser Gly Asn Ile Phe His Lys Glu Gln Gln Arg Thr Ser Ala Gln 
1               5                   10                  15      
Arg Arg Ser Gln Gly Ser Gln 
            20              

<210> 57
<211> 23
<212> PRT
<213> Artificial Sequence


<220> 
<223> C-terminal degron targeted by the CRL2 complex

<400> 57
Ala Ala Ala Val Phe Ser His Phe Ile Met Lys Phe Pro Trp Gln Trp 
1               5                   10                  15      
Ala Phe Leu Leu Gly Leu Phe 
            20              

<210> 58
<211> 23
<212> PRT
<213> Artificial Sequence


<220> 
<223> C-terminal degron targeted by the CRL2 complex

<400> 58
Pro Lys Lys Leu Gln Trp Leu Val Ser Ala Trp Ser Gln Val Gly Ala 
1               5                   10                  15      
Leu Val Ser Arg Glu Arg Gly 
            20              

<210> 59
<211> 23
<212> PRT
<213> Artificial Sequence


<220> 
<223> C-terminal degron targeted by the CRL2 complex

<400> 59
His Pro Asn Asn Glu Asn Leu Pro Gln Leu Ala Asn Met Phe Leu Gln 
1               5                   10                  15      
Tyr Leu Ser Gln Ser Leu His 
            20              

<210> 60
<211> 23
<212> PRT
<213> Artificial Sequence


<220> 
<223> C-terminal degron targeted by the CRL2 complex

<400> 60
Gly Gly Arg Ala Gln Asp Ser Arg Gly Pro Gly Pro Gly Thr Gly Lys 
1               5                   10                  15      
Gly Met Gly Met Gly Arg Gly 
            20              

<210> 61
<211> 23
<212> PRT
<213> Artificial Sequence


<220> 
<223> C-terminal degron targeted by the CRL2 complex

<400> 61
Ser His His His Ser Ser Val Ile Phe Ile Phe Cys Phe Lys Leu Leu 
1               5                   10                  15      
Tyr Phe Met Glu Leu Trp Leu 
            20              

<210> 62
<211> 23
<212> PRT
<213> Artificial Sequence


<220> 
<223> C-terminal degron targeted by the CRL2 complex

<400> 62
Asp Gln Pro Cys Val Lys Arg Trp Ser Ala Met His Glu Ala Ala Lys 
1               5                   10                  15      
Gln Gly Arg Ile Trp Ser Leu 
            20              

<210> 63
<211> 23
<212> PRT
<213> Artificial Sequence


<220> 
<223> C-terminal degron targeted by the CRL2 complex

<400> 63
Leu Pro Ile Pro Val Trp Gly Leu Gln Leu Leu Leu Pro Leu Leu Leu 
1               5                   10                  15      
Pro Ser Phe Ile His Phe Ser 
            20              

<210> 64
<211> 23
<212> PRT
<213> Artificial Sequence


<220> 
<223> C-terminal degron targeted by the CRL2 complex

<400> 64
Ala Pro Asp Pro Pro Cys Ser Ala Leu His Glu His Leu Cys Leu Gly 
1               5                   10                  15      
Ala Ser Ala Ala Pro Glu Ala 
            20              

<210> 65
<211> 23
<212> PRT
<213> Artificial Sequence


<220> 
<223> C-terminal degron targeted by the CRL2 complex

<400> 65
Asp Phe Pro Ser Pro Glu Leu Pro Leu Met Glu Leu Ser Glu Asp Ile 
1               5                   10                  15      
Leu Lys Gly Leu Met Asn Asn 
            20              

<210> 66
<211> 23
<212> PRT
<213> Artificial Sequence


<220> 
<223> C-terminal degron targeted by the CRL2 complex

<400> 66
Tyr Cys Lys Met His Glu Glu Gln Lys Asp Gly Arg Leu Ser Leu Phe 
1               5                   10                  15      
Asp Trp Leu Leu Glu Leu Gly 
            20              

<210> 67
<211> 23
<212> PRT
<213> Artificial Sequence


<220> 
<223> C-terminal degron targeted by the CRL2 complex

<400> 67
Tyr Val Ala Pro Glu Ile Phe Val Tyr Glu Gly Tyr Val Val Ile Ser 
1               5                   10                  15      
Ser Gly Leu Phe Tyr Gln Ser 
            20              

<210> 68
<211> 23
<212> PRT
<213> Artificial Sequence


<220> 
<223> C-terminal degron targeted by the CRL2 complex

<400> 68
Pro Thr Ala Ala Thr Ala Ala Gln Pro Gly Lys Pro Arg Ser Ala Ala 
1               5                   10                  15      
Ala Pro Gly Arg Ala Arg Ala 
            20              

<210> 69
<211> 23
<212> PRT
<213> Artificial Sequence


<220> 
<223> C-terminal degron targeted by the CRL2 complex

<400> 69
Leu Gln Glu Glu Val Met Glu Ala Met Gly Ile Lys Glu Thr Arg Lys 
1               5                   10                  15      
Tyr Lys Lys Val Tyr Trp Tyr 
            20              

<210> 70
<211> 23
<212> PRT
<213> Artificial Sequence


<220> 
<223> C-terminal degron targeted by the CRL2 complex

<400> 70
Ala Phe Met Gln Gly Glu Ile Ala Thr Ile Leu Ala Gly Asp Val Lys 
1               5                   10                  15      
Val Lys Lys Glu Arg Asp Pro 
            20              

<210> 71
<211> 23
<212> PRT
<213> Artificial Sequence


<220> 
<223> C-terminal degron targeted by the CRL2 complex

<400> 71
Val Ile Glu Asp Leu Trp Lys Glu Asn Phe Gln Lys Pro Gly Asn Val 
1               5                   10                  15      
Lys Asn Ser Pro Gly Thr Lys 
            20              

<210> 72
<211> 23
<212> PRT
<213> Artificial Sequence


<220> 
<223> C-terminal degron targeted by the CRL2 complex

<400> 72
His Pro Val Pro Thr Gly Pro Leu Pro Arg Met Tyr Ser Ala Gly Ala 
1               5                   10                  15      
Arg Gly Arg His Gly Ala Arg 
            20              

<210> 73
<211> 23
<212> PRT
<213> Artificial Sequence


<220> 
<223> C-terminal degron targeted by the CRL2 complex

<400> 73
Asp Met Leu Leu Ser Gln Ser Val Ala Leu Pro Pro Cys Thr Glu Pro 
1               5                   10                  15      
Asn Phe Gln Gly Leu Thr His 
            20              

<210> 74
<211> 23
<212> PRT
<213> Artificial Sequence


<220> 
<223> C-terminal degron targeted by the CRL2 complex

<400> 74
Thr His Phe Gly Leu Leu Ala Ser Pro Phe Leu Ser Gly Leu Asn Leu 
1               5                   10                  15      
Leu Gly Lys Arg Lys Thr Arg 
            20              

<210> 75
<211> 23
<212> PRT
<213> Artificial Sequence


<220> 
<223> C-terminal degron targeted by the CRL2 complex

<400> 75
Leu Trp Met Asp Gln Leu Cys Thr Gly Cys Met Lys Thr Pro Phe Leu 
1               5                   10                  15      
Gly Asp Met Ala His Ile Arg 
            20              

<210> 76
<211> 23
<212> PRT
<213> Artificial Sequence


<220> 
<223> C-terminal degron targeted by the CRL2 complex

<400> 76
Pro Glu Gln Pro Ala Ser Ala Ile Val Asn Phe Val Ser Lys Val Met 
1               5                   10                  15      
Ile Gly Ser Pro Lys Lys Val 
            20              

<210> 77
<211> 23
<212> PRT
<213> Artificial Sequence


<220> 
<223> C-terminal degron targeted by the CRL2 complex

<400> 77
Asp Gly Glu Asp Glu Gly Tyr Phe Gln Glu Leu Leu Gly Ser Val Asn 
1               5                   10                  15      
Ser Leu Leu Lys Glu Leu Arg 
            20              

<210> 78
<211> 23
<212> PRT
<213> Artificial Sequence


<220> 
<223> C-terminal degron targeted by the CRL2 complex

<400> 78
Ile Val Pro Met Phe Asp Leu Tyr Thr Tyr Pro Ser Trp Ala Pro Ala 
1               5                   10                  15      
Met Ser Asn Glu Thr Met Pro 
            20              

<210> 79
<211> 23
<212> PRT
<213> Artificial Sequence


<220> 
<223> C-terminal degron targeted by the CRL2 complex

<400> 79
Ser Trp Ser Ser Leu Ser Pro Asp Pro Lys Ser Glu Leu Gly Pro Val 
1               5                   10                  15      
Lys Ala Asp Gly Arg Leu Arg 
            20              

<210> 80
<211> 23
<212> PRT
<213> Artificial Sequence


<220> 
<223> C-terminal degron targeted by the CRL2 complex

<400> 80
Thr Lys Lys Arg His Thr Pro Arg Gly His Ala Glu Ser Thr Ser Asn 
1               5                   10                  15      
Arg Gln Pro Arg Lys Gln Gly 
            20              

<210> 81
<211> 23
<212> PRT
<213> Artificial Sequence


<220> 
<223> C-terminal degron targeted by the CRL2 complex

<400> 81
Arg Arg Leu Asp Gly Lys Glu Glu Asp Glu Lys Met Ser Arg Ala Ser 
1               5                   10                  15      
Asp Arg Phe Arg Gly Leu Arg 
            20              

<210> 82
<211> 23
<212> PRT
<213> Artificial Sequence


<220> 
<223> C-terminal degron targeted by the CRL2 complex

<400> 82
Leu Ile Val Ser Leu Glu Lys Glu Leu Ala Pro Leu Phe Glu Glu Leu 
1               5                   10                  15      
Arg Gln Val Val Glu Val Ser 
            20              

<210> 83
<211> 23
<212> PRT
<213> Artificial Sequence


<220> 
<223> C-terminal degron targeted by the CRL2 complex

<400> 83
Arg Arg Gly Ile Arg Gly Pro Pro Arg Gln Pro Val Glu Ser Ala Arg 
1               5                   10                  15      
Ser Phe Arg Phe Gln Ser Gly 
            20              

<210> 84
<211> 23
<212> PRT
<213> Artificial Sequence


<220> 
<223> C-terminal degron targeted by the CRL2 complex

<400> 84
Lys Ser Glu Leu Val Glu Val Glu Asp Asp Val Tyr Leu Arg His Ser 
1               5                   10                  15      
Ser Ser Leu Thr Tyr Arg Leu 
            20              

<210> 85
<211> 23
<212> PRT
<213> Artificial Sequence


<220> 
<223> C-terminal degron targeted by the CRL2 complex

<400> 85
Met Glu Asn Pro His Ser Leu Leu Thr Met Pro Asp Thr Pro Arg Leu 
1               5                   10                  15      
Phe Ala Tyr Glu Asn Val Ile 
            20              

<210> 86
<211> 23
<212> PRT
<213> Artificial Sequence


<220> 
<223> C-terminal degron targeted by the CRL2 complex

<400> 86
Cys Gly Lys Ala Phe Ile Ser Ser Ser His Phe Arg Leu His Glu Arg 
1               5                   10                  15      
Thr His Met Gly Glu Lys Val 
            20              

<210> 87
<211> 23
<212> PRT
<213> Artificial Sequence


<220> 
<223> C-terminal degron targeted by the CRL2 complex

<400> 87
Ala Gln Asp Phe Leu Ile Arg Pro Ile Gly Glu Lys Leu Pro Thr Ser 
1               5                   10                  15      
Gly Ala Val Leu Leu Trp Ser 
            20              

<210> 88
<211> 23
<212> PRT
<213> Artificial Sequence


<220> 
<223> C-terminal degron targeted by the CRL2 complex

<400> 88
Trp Cys Cys Lys Lys Glu Val Gln Glu Thr Arg Arg Glu Arg Arg Arg 
1               5                   10                  15      
Leu Met Ser Met Glu Met Asp 
            20              

<210> 89
<211> 23
<212> PRT
<213> Artificial Sequence


<220> 
<223> C-terminal degron targeted by the CRL2 complex

<400> 89
Ser Leu Thr Trp Gly Val Gly Leu Ala Leu Ala Pro Ala Leu Trp Trp 
1               5                   10                  15      
Gly Val Val Cys Pro Ser Cys 
            20              

<210> 90
<211> 23
<212> PRT
<213> Artificial Sequence


<220> 
<223> C-terminal degron targeted by the CRL2 complex

<400> 90
Glu Gln Thr Ala Ser Leu Val Lys Gln Leu Gly Leu Ser Val Asp Val 
1               5                   10                  15      
Leu Gln His Leu Lys Gln Leu 
            20              

<210> 91
<211> 23
<212> PRT
<213> Artificial Sequence


<220> 
<223> C-terminal degron targeted by the CRL2 complex

<400> 91
Phe Arg Ser Leu Glu Leu Arg Asn Thr Phe Arg Glu Ile Leu Cys Gly 
1               5                   10                  15      
Cys Asn Gly Met Asn Leu Gly 
            20              

<210> 92
<211> 23
<212> PRT
<213> Artificial Sequence


<220> 
<223> C-terminal degron targeted by the CRL2 complex

<400> 92
Leu Ala Ala Gly Ala Lys Val Pro Pro Asp Leu Arg Arg Arg Leu Glu 
1               5                   10                  15      
Arg Leu Arg Gly Gln Lys Asp 
            20              

<210> 93
<211> 23
<212> PRT
<213> Artificial Sequence


<220> 
<223> C-terminal degron targeted by the CRL2 complex

<400> 93
Leu Ser Val Asn Gln Lys Leu Val Ala Ala Tyr Ile Leu Gly Leu Ile 
1               5                   10                  15      
Thr Met Ala Ile Leu Arg Thr 
            20              

<210> 94
<211> 23
<212> PRT
<213> Artificial Sequence


<220> 
<223> C-terminal degron targeted by the CRL2 complex

<400> 94
Tyr Leu Gly Phe Lys Arg Gly Ala Asp Pro Gly Met Pro Glu Pro Thr 
1               5                   10                  15      
Val Leu Ser Leu Leu Trp Gly 
            20              

<210> 95
<211> 23
<212> PRT
<213> Artificial Sequence


<220> 
<223> C-terminal degron targeted by the CRL2 complex

<400> 95
Ile Arg Glu Val Leu Lys Met Asp Thr Ser Ile Lys Asn Gln Thr Gln 
1               5                   10                  15      
Leu Asn Thr Thr Trp Leu Arg 
            20              

<210> 96
<211> 23
<212> PRT
<213> Artificial Sequence


<220> 
<223> C-terminal degron targeted by the CRL2 complex

<400> 96
Tyr Ala Val Glu Phe His Pro Asp Thr Gly Asp Ile Ile Met Glu Phe 
1               5                   10                  15      
Arg His Ala Asp Thr Pro Asp 
            20              

<210> 97
<211> 23
<212> PRT
<213> Artificial Sequence


<220> 
<223> C-terminal degron targeted by the CRL2 complex

<400> 97
Pro Leu Pro Thr Thr Leu Trp Thr Cys Val Asp Ala Arg Ser Ala Ala 
1               5                   10                  15      
Gly Ala Gly Leu Arg Gly Arg 
            20              

<210> 98
<211> 23
<212> PRT
<213> Artificial Sequence


<220> 
<223> C-terminal degron targeted by the CRL2 complex

<400> 98
Gly Gln Glu Met Val Gly Arg Gly Met His Gly Ala Gly Val Thr Arg 
1               5                   10                  15      
Ser Asn Ser Gly Ser Gln Glu 
            20              

<210> 99
<211> 23
<212> PRT
<213> Artificial Sequence


<220> 
<223> C-terminal degron targeted by the CRL2 complex

<400> 99
Leu Glu Asn Gln Asn Ser Leu Leu Ser Ser Ser Ser Gly Met Phe Lys 
1               5                   10                  15      
Lys Glu Ser Asp Ser Ile Ile 
            20              

<210> 100
<211> 23
<212> PRT
<213> Artificial Sequence


<220> 
<223> C-terminal degron targeted by the CRL2 complex

<400> 100
Ile Ile Gly Gly Ile Val Phe Leu Ala Phe Ala Phe Ser Ala Leu Phe 
1               5                   10                  15      
Ile Ser Pro Asp Ser Gly Phe 
            20              

<210> 101
<211> 23
<212> PRT
<213> Artificial Sequence


<220> 
<223> C-terminal degron targeted by the CRL2 complex

<400> 101
Arg Leu Glu Val Ala Ala Leu Val Leu Gly Cys Leu Ile Pro Leu Ile 
1               5                   10                  15      
Leu Ser Val Gly His Gln His 
            20              

<210> 102
<211> 23
<212> PRT
<213> Artificial Sequence


<220> 
<223> C-terminal degron targeted by the CRL2 complex

<400> 102
Leu Glu Glu Ala Asp His Leu Gln Glu Glu Tyr Lys Lys Gln Pro Ala 
1               5                   10                  15      
His Leu Glu Arg Leu Tyr Gly 
            20              

<210> 103
<211> 23
<212> PRT
<213> Artificial Sequence


<220> 
<223> C-terminal degron targeted by the CRL2 complex

<400> 103
Lys Val Leu Arg Arg Trp Val Asp Glu Glu Trp Pro Lys Arg Glu Arg 
1               5                   10                  15      
Gly Asp Pro Ser Arg His Phe 
            20              

<210> 104
<211> 23
<212> PRT
<213> Artificial Sequence


<220> 
<223> C-terminal degron targeted by the CRL2 complex

<400> 104
Leu Gln Arg Lys Asn Tyr Asn Asp Cys Met Leu Asn Thr Ala Ser Gln 
1               5                   10                  15      
Thr Val Thr Thr Glu Lys Phe 
            20              

<210> 105
<211> 23
<212> PRT
<213> Artificial Sequence


<220> 
<223> C-terminal degron targeted by the CRL2 complex

<400> 105
Gly Ala Ala Pro Gly Arg Gly Ala Ala Gly Arg Ala Arg Cys Leu Gly 
1               5                   10                  15      
Pro Ser Ala Arg Gly Pro Gly 
            20              

<210> 106
<211> 23
<212> PRT
<213> Artificial Sequence


<220> 
<223> C-terminal degron targeted by the CRL2 complex

<400> 106
Phe Ala Ser His Ile Arg Ala Arg Asp Ala Ala Gly Ser Gly Asp Lys 
1               5                   10                  15      
Pro Gly Ala Asp Thr Gly Arg 
            20              

<210> 107
<211> 23
<212> PRT
<213> Artificial Sequence


<220> 
<223> C-terminal degron targeted by the CRL2 complex

<400> 107
Ser Gln Thr Pro Val Asp Pro Gln Glu Gly Thr Thr Pro Leu Met Gly 
1               5                   10                  15      
Gln Ala Gly Thr Pro Gly Ala 
            20              

<210> 108
<211> 23
<212> PRT
<213> Artificial Sequence


<220> 
<223> C-terminal degron targeted by the CRL2 complex

<400> 108
Ser Leu Phe Leu Pro Tyr Tyr Pro Pro Asp Ser Glu Ala Arg Arg Pro 
1               5                   10                  15      
Cys Pro Gly Ala Thr Gly Arg 
            20              

<210> 109
<211> 23
<212> PRT
<213> Artificial Sequence


<220> 
<223> C-terminal degron targeted by the CRL2 complex

<400> 109
Tyr Ser Ile Lys Thr Lys Gln Ile Gln Tyr Gly Ile Ile Arg Leu Leu 
1               5                   10                  15      
Ser Lys His Arg Phe Ser Arg 
            20              

<210> 110
<211> 23
<212> PRT
<213> Artificial Sequence


<220> 
<223> C-terminal degron targeted by the CRL2 complex

<400> 110
Phe Leu Asn Tyr Pro Pro Phe Thr Arg Ser Leu Arg Gly Ser Gln Arg 
1               5                   10                  15      
Thr Trp Ala Pro Glu Pro Arg 
            20              

<210> 111
<211> 23
<212> PRT
<213> Artificial Sequence


<220> 
<223> C-terminal degron targeted by the CRL2 complex

<400> 111
Ser Ala Ser Cys Pro Ile Phe Val Ile Thr Ile Glu Asn Tyr Cys Asn 
1               5                   10                  15      
Leu Pro Gln Arg Lys Phe Pro 
            20              

<210> 112
<211> 23
<212> PRT
<213> Artificial Sequence


<220> 
<223> C-terminal degron targeted by the CRL2 complex

<400> 112
Thr Phe Phe Ile Phe Leu Asn Lys Thr Phe Gln Trp Pro Asn Ser Gln 
1               5                   10                  15      
Asp Ile Gln Arg Phe Met Trp 
            20              

<210> 113
<211> 23
<212> PRT
<213> Artificial Sequence


<220> 
<223> C-terminal degron targeted by the CRL2 complex

<400> 113
Val Glu Arg Pro Leu Asp Asp Ile Ile Ala Gln Leu Pro Pro Pro Ile 
1               5                   10                  15      
Lys Lys Lys Lys Phe Gly Thr 
            20              

<210> 114
<211> 23
<212> PRT
<213> Artificial Sequence


<220> 
<223> C-terminal degron targeted by the CRL2 complex

<400> 114
His Ser Leu Arg Ala Val Ser Thr Asp Pro Pro His His Asp His His 
1               5                   10                  15      
Asp Glu Phe Cys Leu Met Pro 
            20              

<210> 115
<211> 23
<212> PRT
<213> Artificial Sequence


<220> 
<223> C-terminal degron targeted by the CRL2 complex

<400> 115
Thr Glu Ser Arg Leu Asp Tyr Pro Asp His Ala Arg Ser Ala Ser Asp 
1               5                   10                  15      
Tyr Arg Pro Arg Pro Trp Gly 
            20              

<210> 116
<211> 23
<212> PRT
<213> Artificial Sequence


<220> 
<223> C-terminal degron targeted by the CRL2 complex

<400> 116
Val Glu Glu Val Arg Pro Gln Ile Thr Ala Leu Val Arg Lys Leu Ile 
1               5                   10                  15      
Leu Leu Lys Arg Glu Asp Leu 
            20              

<210> 117
<211> 23
<212> PRT
<213> Artificial Sequence


<220> 
<223> C-terminal degron targeted by the CRL2 complex

<400> 117
Tyr Asp Arg Ala Met Ile His Leu Ser Arg Val Arg Gly Pro His Ser 
1               5                   10                  15      
Phe Val Thr Ser Ser Tyr Leu 
            20              

<210> 118
<211> 23
<212> PRT
<213> Artificial Sequence


<220> 
<223> C-terminal degron targeted by the CRL2 complex

<400> 118
Tyr Met Asn Glu Val Tyr Thr Asn Gln Pro Thr Gly Asp Tyr Phe Thr 
1               5                   10                  15      
Gln Phe Asn Thr Gly Ser Arg 
            20              

<210> 119
<211> 23
<212> PRT
<213> Artificial Sequence


<220> 
<223> C-terminal degron targeted by the CRL2 complex

<400> 119
His Ala Cys Tyr Leu His Lys Pro Gln Asp Phe His Leu Val Leu Leu 
1               5                   10                  15      
Ala Phe Leu Asp His Leu Pro 
            20              

<210> 120
<211> 23
<212> PRT
<213> Artificial Sequence


<220> 
<223> C-terminal degron targeted by the CRL2 complex

<400> 120
Thr Lys Leu Phe Val Ala Gly Gly Pro Leu Pro Ser Gly Leu His Gly 
1               5                   10                  15      
Asn Tyr Ala Gly Leu Trp Ser 
            20              

<210> 121
<211> 23
<212> PRT
<213> Artificial Sequence


<220> 
<223> C-terminal degron targeted by the CRL2 complex

<400> 121
Pro Pro Leu Val Gly Pro Lys Ala Gln Leu Ser Gly Leu Gln Leu Gln 
1               5                   10                  15      
Pro Cys Leu Tyr Lys Arg Arg 
            20              

<210> 122
<211> 23
<212> PRT
<213> Artificial Sequence


<220> 
<223> C-terminal degron targeted by the CRL2 complex

<400> 122
Leu Phe Ala Lys Val Lys Glu Thr Cys Gln Arg Leu Leu Glu Lys Pro 
1               5                   10                  15      
Lys Gly Ser Phe Ile Leu Leu 
            20              

<210> 123
<211> 23
<212> PRT
<213> Artificial Sequence


<220> 
<223> C-terminal degron targeted by the CRL2 complex

<400> 123
Met Thr Glu Asp Glu Thr Pro Lys Lys Thr Thr Pro Ile Leu Arg Ala 
1               5                   10                  15      
Ser Ala Arg Arg His Arg Ser 
            20              

<210> 124
<211> 23
<212> PRT
<213> Artificial Sequence


<220> 
<223> C-terminal degron targeted by the CRL2 complex

<400> 124
Glu Asp Lys Thr Asp Ile Gln Lys Arg Gln Ile Lys Asp Leu Glu Glu 
1               5                   10                  15      
Lys Ser Asn Arg Lys His Gly 
            20              

<210> 125
<211> 23
<212> PRT
<213> Artificial Sequence


<220> 
<223> C-terminal degron targeted by the CRL2 complex

<400> 125
Ala Ala Asp His Arg Gly Gly Leu Asp Gly Trp Glu Gln Pro Gly Ala 
1               5                   10                  15      
Gly Gln Pro Pro Ser Asp Thr 
            20              

<210> 126
<211> 23
<212> PRT
<213> Artificial Sequence


<220> 
<223> C-terminal degron targeted by the CRL2 complex

<400> 126
Pro Arg Thr Gly Pro Cys Arg Gln Arg Ala Val Met Glu Thr Ile Ala 
1               5                   10                  15      
Val Gly Cys Thr Cys Ile Phe 
            20              

<210> 127
<211> 23
<212> PRT
<213> Artificial Sequence


<220> 
<223> C-terminal degron targeted by the CRL2 complex

<400> 127
Gln Asp Tyr Glu Glu Trp Lys Arg Lys Ile Leu Glu Asn Ala Ala Ser 
1               5                   10                  15      
Ala Gln Lys Ala Thr Ala Glu 
            20              

<210> 128
<211> 23
<212> PRT
<213> Artificial Sequence


<220> 
<223> C-terminal degron targeted by the CRL2 complex

<400> 128
Cys His Ser Cys His Val Lys Arg Leu Glu Lys Arg Pro Ser Ser Thr 
1               5                   10                  15      
Ala Leu His Gln His His Phe 
            20              

<210> 129
<211> 23
<212> PRT
<213> Artificial Sequence


<220> 
<223> C-terminal degron targeted by the CRL2 complex

<400> 129
Glu Thr Leu Asp Thr Met Leu Asp Gly Leu Gly Arg Ile Arg Asp Gln 
1               5                   10                  15      
Leu Ser Ala Val Ala Ser Lys 
            20              

<210> 130
<211> 23
<212> PRT
<213> Artificial Sequence


<220> 
<223> C-terminal degron targeted by the CRL2 complex

<400> 130
Gly His Gly Gln Ile Ser His Lys Met Ala Tyr Glu Arg Ser Ala Met 
1               5                   10                  15      
Gln Asn Tyr Glu Arg Arg Arg 
            20              

<210> 131
<211> 23
<212> PRT
<213> Artificial Sequence


<220> 
<223> C-terminal degron targeted by the CRL2 complex

<400> 131
Thr His Glu Leu Cys Glu Arg Phe Ala Arg Ile Met Leu Ser Leu Ser 
1               5                   10                  15      
Arg Thr Pro Ala Asp Gly Arg 
            20              

<210> 132
<211> 23
<212> PRT
<213> Artificial Sequence


<220> 
<223> C-terminal degron targeted by the CRL2 complex

<400> 132
Arg Cys Leu His Met Phe Leu Gln Glu Glu Ala Ile Asp Arg Asn Tyr 
1               5                   10                  15      
Val Pro Gly Lys Val Arg Gln 
            20              

<210> 133
<211> 23
<212> PRT
<213> Artificial Sequence


<220> 
<223> C-terminal degron targeted by the CRL2 complex

<400> 133
Ser Ala Leu Arg Thr Leu Gly Lys Leu Glu Glu Glu His Met Val Ile 
1               5                   10                  15      
Val Ile Val Arg Asp Thr Ala 
            20              

<210> 134
<211> 23
<212> PRT
<213> Artificial Sequence


<220> 
<223> C-terminal degron targeted by the CRL2 complex

<400> 134
Leu Lys Lys Leu Glu Asn Leu Glu Ser Leu Asp Leu Phe Thr Cys Glu 
1               5                   10                  15      
Val Thr Asn Leu Asn Asn Tyr 
            20              

<210> 135
<211> 23
<212> PRT
<213> Artificial Sequence


<220> 
<223> C-terminal degron targeted by the CRL2 complex

<400> 135
Tyr Lys Lys Gly Ile Ile Arg Lys Pro Asp Ile Ser Gln Arg Leu Val 
1               5                   10                  15      
Tyr Gln Phe Val His Pro Ile 
            20              

<210> 136
<211> 23
<212> PRT
<213> Artificial Sequence


<220> 
<223> C-terminal degron targeted by the CRL2 complex

<400> 136
Pro Glu Asp Pro Asp Trp Ile Lys Arg Leu Leu Gln Ser Pro Cys Pro 
1               5                   10                  15      
Phe Cys Asp Ser Pro Val Phe 
            20              

<210> 137
<211> 23
<212> PRT
<213> Artificial Sequence


<220> 
<223> C-terminal degron targeted by the CRL2 complex

<400> 137
Asn Asn Leu Ser Asn Phe Ile Thr His Lys Lys Phe Tyr Cys Ser Ser 
1               5                   10                  15      
His Ala Ala Glu His Val Lys 
            20              

<210> 138
<211> 23
<212> PRT
<213> Artificial Sequence


<220> 
<223> C-terminal degron targeted by the CRL2 complex

<400> 138
His Pro Ile Gly Asp Lys Ser Phe Gln Asn Tyr Ile Arg Gln Gln Ser 
1               5                   10                  15      
Glu Thr Ser Thr His Ser Ile 
            20              

<210> 139
<211> 23
<212> PRT
<213> Artificial Sequence


<220> 
<223> C-terminal degron targeted by the CRL2 complex

<400> 139
Glu Gln Arg Asn Ser Arg Trp Asn Thr Val Leu Arg Ala Val Lys Ala 
1               5                   10                  15      
Lys Thr His His Leu Glu Pro 
            20              

<210> 140
<211> 23
<212> PRT
<213> Artificial Sequence


<220> 
<223> C-terminal degron targeted by the CRL2 complex

<400> 140
Leu Pro Ala Leu Phe Thr Asp Leu Tyr Ser Gln Glu Ile Thr Ala Glu 
1               5                   10                  15      
Glu Ala Arg Glu Ala Leu Pro 
            20              

<210> 141
<211> 23
<212> PRT
<213> Artificial Sequence


<220> 
<223> C-terminal degron targeted by the CRL2 complex

<400> 141
Trp Gln Tyr Asn Lys Leu His Arg Asp Phe Arg Ala Lys Gly Tyr Arg 
1               5                   10                  15      
Lys Glu Asp Phe Leu Gly Pro 
            20              

<210> 142
<211> 23
<212> PRT
<213> Artificial Sequence


<220> 
<223> C-terminal degron targeted by the CRL2 complex

<400> 142
Leu Leu Tyr Glu Glu Pro Phe Thr Ala Glu Ile Tyr Arg Gln Lys Ala 
1               5                   10                  15      
Ser Gly Ser His Lys Arg Ser 
            20              

<210> 143
<211> 23
<212> PRT
<213> Artificial Sequence


<220> 
<223> C-terminal degron targeted by the CRL2 complex

<400> 143
Lys Asn Pro Thr Ala Phe Lys Lys Tyr Leu Gln Glu Thr Tyr Ser Lys 
1               5                   10                  15      
Gln Val Thr Ser Gln Glu Pro 
            20              

<210> 144
<211> 23
<212> PRT
<213> Artificial Sequence


<220> 
<223> C-terminal degron targeted by the CRL2 complex

<400> 144
Val Gln Cys Gln Asn Ala Leu Val Ile Met Lys Thr Gly Thr Gln Asn 
1               5                   10                  15      
Met Arg Val Ser Phe Gln Leu 
            20              

<210> 145
<211> 23
<212> PRT
<213> Artificial Sequence


<220> 
<223> C-terminal degron targeted by the CRL2 complex

<400> 145
Pro Ile Lys Gly Leu Gly Leu Pro Gly Cys Ile Pro Gly Leu Leu Pro 
1               5                   10                  15      
Glu Asn Ser Met Asp Cys Ile 
            20              

<210> 146
<211> 23
<212> PRT
<213> Artificial Sequence


<220> 
<223> C-terminal degron targeted by the CRL2 complex

<400> 146
Asp Trp Ala Glu Gly Leu Lys Ser Gly Pro Glu Glu Gln Pro Arg Asp 
1               5                   10                  15      
Thr Ala Ser Pro Val Pro Ala 
            20              

<210> 147
<211> 23
<212> PRT
<213> Artificial Sequence


<220> 
<223> C-terminal degron targeted by the CRL2 complex

<400> 147
Tyr Gly Thr His Val Gly Tyr Ser Ser Ser Arg Glu Ile Thr Glu Ala 
1               5                   10                  15      
Ala Val Leu Leu Phe Tyr Arg 
            20              

<210> 148
<211> 23
<212> PRT
<213> Artificial Sequence


<220> 
<223> C-terminal degron targeted by the CRL2 complex

<400> 148
Pro Pro Gln Ala Leu Ala Phe Pro Glu His Gly Ser Val Tyr Glu Tyr 
1               5                   10                  15      
Arg Arg Ala Gln Glu Ala Val 
            20              

<210> 149
<211> 23
<212> PRT
<213> Artificial Sequence


<220> 
<223> C-terminal degron targeted by the CRL2 complex

<400> 149
Ile Ala Gly Arg Tyr Glu Arg Ala Ser Gln Gly Pro Ala Ser His Ser 
1               5                   10                  15      
Arg Phe Ser Arg Asp Arg Gly 
            20              

<210> 150
<211> 23
<212> PRT
<213> Artificial Sequence


<220> 
<223> C-terminal degron targeted by the CRL2 complex

<400> 150
Ser Leu Gly Asp Phe Glu Gln Leu Val Thr Ser Leu Thr Leu His Asp 
1               5                   10                  15      
Pro Asn Ile Phe Gly Pro Gln 
            20              

<210> 151
<211> 23
<212> PRT
<213> Artificial Sequence


<220> 
<223> C-terminal degron targeted by the CRL2 complex

<400> 151
Arg Glu Ile Ser Met Arg Val Arg Phe Phe Pro Tyr Asn Tyr His Arg 
1               5                   10                  15      
Gln Lys Glu Arg Thr Val His 
            20              

<210> 152
<211> 23
<212> PRT
<213> Artificial Sequence


<220> 
<223> C-terminal degron targeted by the CRL2 complex

<400> 152
Lys Tyr Ser Thr Met Glu Thr Val Glu Glu Ala Leu Gln Glu Ala Ile 
1               5                   10                  15      
Asn Asn Asn Arg Gly Phe Gly 
            20              

<210> 153
<211> 23
<212> PRT
<213> Artificial Sequence


<220> 
<223> C-terminal degron targeted by the CRL2 complex

<400> 153
Leu Val Gln Ile Leu Asp Asn Glu Met Lys Leu Asn Val His Met Asp 
1               5                   10                  15      
Ser Ile Pro His His Arg Ser 
            20              

<210> 154
<211> 23
<212> PRT
<213> Artificial Sequence


<220> 
<223> C-terminal degron targeted by the CRL2 complex

<400> 154
Ser Leu Thr Asp Val Ala Leu Glu His His Glu Glu Cys Asp Cys Val 
1               5                   10                  15      
Cys Arg Gly Ser Thr Gly Gly 
            20              

<210> 155
<211> 23
<212> PRT
<213> Artificial Sequence


<220> 
<223> C-terminal degron targeted by the CRL2 complex

<400> 155
Val Ile Thr Ala Ser Ala Val Ala Leu Ile Gly Cys Cys Phe Val Ala 
1               5                   10                  15      
Leu Phe Val Arg Tyr Val Asp 
            20              

<210> 156
<211> 23
<212> PRT
<213> Artificial Sequence


<220> 
<223> C-terminal degron targeted by the CRL2 complex

<400> 156
Thr Asp Pro Ala His Thr Glu Glu Phe Ala Tyr Glu Asn Ser Pro Glu 
1               5                   10                  15      
Leu Asn Pro Arg Leu Phe Lys 
            20              

<210> 157
<211> 23
<212> PRT
<213> Artificial Sequence


<220> 
<223> C-terminal degron targeted by the CRL2 complex

<400> 157
Gln Glu Lys Gly Lys Gln Gln Asp Thr Val Leu Gly Gly Arg Ala Leu 
1               5                   10                  15      
Ser Asn Arg Gln His Ala Ser 
            20              

<210> 158
<211> 23
<212> PRT
<213> Artificial Sequence


<220> 
<223> C-terminal degron targeted by the CRL2 complex

<400> 158
Leu Val Asp Arg Leu Tyr Thr Asn Ile Ser Val Asn Leu Met Pro Glu 
1               5                   10                  15      
Leu Ala Pro Ile Glu Asp Tyr 
            20              

<210> 159
<211> 23
<212> PRT
<213> Artificial Sequence


<220> 
<223> C-terminal degron targeted by the CRL2 complex

<400> 159
Lys Thr Arg Asn Gln Asp Glu Gly Ile Leu Pro Ser Gly Arg Arg Gly 
1               5                   10                  15      
Thr Ala Arg Gly Pro Ala Arg 
            20              

<210> 160
<211> 23
<212> PRT
<213> Artificial Sequence


<220> 
<223> C-terminal degron targeted by the CRL2 complex

<400> 160
Leu Ala Ala Tyr Leu Glu Ser Arg Gln Asn Tyr Lys Val Ile Gly His 
1               5                   10                  15      
Glu Asp Leu Glu Thr Ala Val 
            20              

<210> 161
<211> 23
<212> PRT
<213> Artificial Sequence


<220> 
<223> C-terminal degron targeted by the CRL2 complex

<400> 161
Arg Phe Glu Val Asn Ile Ser Glu Leu Pro Asp Glu Ile Asp Ile Ser 
1               5                   10                  15      
Ser Tyr Ile Glu Gln Thr Arg 
            20              

<210> 162
<211> 23
<212> PRT
<213> Artificial Sequence


<220> 
<223> C-terminal degron targeted by the CRL2 complex

<400> 162
Arg Gly Ser Gln Lys Lys His Ile Ser Pro Val Gln Ala Leu Ser Glu 
1               5                   10                  15      
Phe Lys Ala Met Asp Ser Phe 
            20              

<210> 163
<211> 23
<212> PRT
<213> Artificial Sequence


<220> 
<223> C-terminal degron targeted by the CRL2 complex

<400> 163
Ala Val Gln Ser Pro Gly Ile Pro Gln Ser Asn Ser Gly Val Ser Thr 
1               5                   10                  15      
Leu His Gly Ile Arg Ala Trp 
            20              

<210> 164
<211> 23
<212> PRT
<213> Artificial Sequence


<220> 
<223> C-terminal degron targeted by the CRL2 complex

<400> 164
Gly Val Tyr Thr Gln Val Thr Lys Phe Leu Asn Trp Ile Lys Ala Thr 
1               5                   10                  15      
Ile Lys Ser Glu Ser Gly Phe 
            20              

<210> 165
<211> 23
<212> PRT
<213> Artificial Sequence


<220> 
<223> C-terminal degron targeted by the CRL2 complex

<400> 165
Arg Ser Phe Thr Lys Met Ser Ser Met Asn Glu Arg Thr Ser Met Asn 
1               5                   10                  15      
Glu Arg Glu Thr Gly Met Leu 
            20              

<210> 166
<211> 23
<212> PRT
<213> Artificial Sequence


<220> 
<223> C-terminal degron targeted by the CRL2 complex

<400> 166
Thr Gly Lys Ser Cys Asn Gln Gly Pro Tyr Pro Leu Val Gln Ala Val 
1               5                   10                  15      
Lys Arg Ser Leu Gly Ser Leu 
            20              

<210> 167
<211> 23
<212> PRT
<213> Artificial Sequence


<220> 
<223> C-terminal degron targeted by the CRL2 complex

<400> 167
Val Phe Ser Asp Leu Lys Asn Glu Ser Gly Gln Glu Asp Lys Lys Arg 
1               5                   10                  15      
Leu Leu Leu Gly Leu Asp Arg 
            20              

<210> 168
<211> 23
<212> PRT
<213> Artificial Sequence


<220> 
<223> C-terminal degron targeted by the CRL2 complex

<400> 168
Gly Gly Leu Val Ser Ser Ile Ala Gly Met Ile Thr Val Ala Tyr Pro 
1               5                   10                  15      
Gln Met Lys Leu Lys Thr Arg 
            20              

<210> 169
<211> 23
<212> PRT
<213> Artificial Sequence


<220> 
<223> C-terminal degron targeted by the CRL2 complex

<400> 169
Gln Ala Leu Arg Val Ala Arg Met Pro Gly Leu Glu Arg Ser Val Arg 
1               5                   10                  15      
Glu Arg Phe Leu Pro Val His 
            20              

<210> 170
<211> 23
<212> PRT
<213> Artificial Sequence


<220> 
<223> C-terminal degron targeted by the CRL2 complex

<400> 170
Pro Val Ser Lys Pro Gly Ala Leu Arg Arg Ser Leu Ser Arg Ser Met 
1               5                   10                  15      
Ser Gln Glu Ala Gln Arg Gly 
            20              

<210> 171
<211> 23
<212> PRT
<213> Artificial Sequence


<220> 
<223> C-terminal degron targeted by the CRL2 complex

<400> 171
Pro Tyr Thr Arg Tyr Glu Asn Ile Thr Phe Asn Cys Cys Asn His Cys 
1               5                   10                  15      
Arg Gly Glu Leu Ile Ala Leu 
            20              

<210> 172
<211> 23
<212> PRT
<213> Artificial Sequence


<220> 
<223> C-terminal degron targeted by the CRL2 complex

<400> 172
Met Glu Gln Val Lys Asp Phe Ala Ala Asn Val Tyr Glu Ala Phe Ser 
1               5                   10                  15      
Thr Pro Gln Gln Leu Glu Lys 
            20              

<210> 173
<211> 23
<212> PRT
<213> Artificial Sequence


<220> 
<223> C-terminal degron targeted by the CRL2 complex

<400> 173
Thr Glu Tyr Asn Leu Lys Tyr Leu Phe Tyr Pro Gln Phe Leu Cys Glu 
1               5                   10                  15      
Pro Asp Ser Pro Lys Cys Asp 
            20              

<210> 174
<211> 23
<212> PRT
<213> Artificial Sequence


<220> 
<223> C-terminal degron targeted by the CRL2 complex

<400> 174
Lys Thr Leu Gln Ser Trp Arg Arg Phe Tyr His Arg Leu Ser His Ser 
1               5                   10                  15      
Ser Lys Gly Glu Thr Ala Val 
            20              

<210> 175
<211> 23
<212> PRT
<213> Artificial Sequence


<220> 
<223> C-terminal degron targeted by the CRL2 complex

<400> 175
Leu Phe Leu Ala Ile Phe Ile Tyr Ala Phe Pro Asn Tyr Ala Ala Met 
1               5                   10                  15      
Lys Leu Val Lys Pro Phe Ser 
            20              

<210> 176
<211> 23
<212> PRT
<213> Artificial Sequence


<220> 
<223> C-terminal degron targeted by the CRL2 complex

<400> 176
Gly Gln Asn Leu Arg Phe Gln Arg Leu Phe Thr Glu Cys Gln Glu Gln 
1               5                   10                  15      
Leu Asp Ile Leu Arg Asp Lys 
            20              

<210> 177
<211> 23
<212> PRT
<213> Artificial Sequence


<220> 
<223> C-terminal degron targeted by the CRL2 complex

<400> 177
Cys Phe Asp Ser Arg Ile Pro Gly Val Pro Trp Cys Phe Lys Pro Leu 
1               5                   10                  15      
Gln Glu Ala Glu Cys Thr Phe 
            20              

<210> 178
<211> 23
<212> PRT
<213> Artificial Sequence


<220> 
<223> C-terminal degron targeted by the CRL2 complex

<400> 178
Gly Ile Glu Trp Met Val Lys Cys Val Val Arg Asn Val His Arg Pro 
1               5                   10                  15      
Pro Arg Gln Arg Asp Ile Thr 
            20              

<210> 179
<211> 23
<212> PRT
<213> Artificial Sequence


<220> 
<223> C-terminal degron targeted by the CRL2 complex

<400> 179
Arg Pro Ser Phe Glu Asp Leu Leu Arg Thr Ile Asp Glu Leu Val Glu 
1               5                   10                  15      
Cys Glu Glu Thr Phe Gly Arg 
            20              

<210> 180
<211> 23
<212> PRT
<213> Artificial Sequence


<220> 
<223> C-terminal degron targeted by the CRL2 complex

<400> 180
Leu Glu Asn Asp Leu Lys Ser Leu Gln Phe Tyr Ser Val Glu Asn Gly 
1               5                   10                  15      
Asp Cys Leu Leu Val Arg Trp 
            20              

<210> 181
<211> 23
<212> PRT
<213> Artificial Sequence


<220> 
<223> C-terminal degron targeted by the CRL2 complex

<400> 181
Cys Ser Asp Gly Thr Ser Phe Ala Glu Glu Val Glu Lys Pro Thr Lys 
1               5                   10                  15      
Cys Gly Cys Ala Leu Cys Ala 
            20              

<210> 182
<211> 23
<212> PRT
<213> Artificial Sequence


<220> 
<223> C-terminal degron targeted by the CRL2 complex

<400> 182
Glu Pro Arg Ser Pro Pro Gly Pro Phe Asp Glu Cys Glu Asp Asp Tyr 
1               5                   10                  15      
Asn Tyr Tyr Tyr Thr Arg Ser 
            20              

<210> 183
<211> 23
<212> PRT
<213> Artificial Sequence


<220> 
<223> C-terminal degron targeted by the CRL2 complex

<400> 183
Val Lys Phe Met Phe Ser Tyr Pro Cys Ser Leu Tyr Tyr Pro Phe Phe 
1               5                   10                  15      
Tyr Gly Ala Ala Glu Pro His 
            20              

<210> 184
<211> 23
<212> PRT
<213> Artificial Sequence


<220> 
<223> C-terminal degron targeted by the CRL2 complex

<400> 184
Ala Gly Leu Cys Tyr Phe Asn Tyr His Asp Val Gly Ile Cys Lys Ala 
1               5                   10                  15      
Val Ala Met Leu Trp Lys Leu 
            20              

<210> 185
<211> 23
<212> PRT
<213> Artificial Sequence


<220> 
<223> C-terminal degron targeted by the CRL2 complex

<400> 185
Met Gln Gly Gly Phe Gly Gly Gln Ser Arg Gly Ser Arg Pro Ser Asp 
1               5                   10                  15      
Ala Arg Phe Thr Arg Arg Tyr 
            20              

<210> 186
<211> 23
<212> PRT
<213> Artificial Sequence


<220> 
<223> C-terminal degron targeted by the CRL2 complex

<400> 186
Arg Ala Lys Glu Met Leu Gln His Asn Gln Leu Arg Val Lys Arg Ser 
1               5                   10                  15      
Pro Gly Leu Gln Asp His Leu 
            20              

<210> 187
<211> 23
<212> PRT
<213> Artificial Sequence


<220> 
<223> C-terminal degron targeted by the CRL2 complex

<400> 187
Pro Arg Ser Val Ile Asn Leu Leu Arg Asn Val Cys Ser Glu Ala Ala 
1               5                   10                  15      
Gln Lys Arg Ser Leu Asp Arg 
            20              

<210> 188
<211> 23
<212> PRT
<213> Artificial Sequence


<220> 
<223> C-terminal degron targeted by the CRL2 complex

<400> 188
Leu Leu Ser Val Ala Met Phe Leu Leu Val Leu Gly Phe Ile Ile Ala 
1               5                   10                  15      
Leu Ala Leu Gly Ser Arg Lys 
            20              

<210> 189
<211> 23
<212> PRT
<213> Artificial Sequence


<220> 
<223> C-terminal degron targeted by the CRL2 complex

<400> 189
Phe Ala Ala Asp Ala Val Lys Leu Glu Arg Met Leu Thr Glu Arg Met 
1               5                   10                  15      
Phe Asn Ala Glu Asn Gly Lys 
            20              

<210> 190
<211> 23
<212> PRT
<213> Artificial Sequence


<220> 
<223> C-terminal degron targeted by the CRL2 complex

<400> 190
Glu His Gln Glu Arg Lys Leu His Gly Thr Leu Pro Lys Leu Asn Phe 
1               5                   10                  15      
Gly Met Leu Arg Lys Met Gly 
            20              

<210> 191
<211> 23
<212> PRT
<213> Artificial Sequence


<220> 
<223> C-terminal degron targeted by the CRL2 complex

<400> 191
Cys Thr Val Arg Trp Glu Asn Arg Thr Met Asn Cys Ile Val Asn Val 
1               5                   10                  15      
Phe Ala Ile Ala Ile Val Leu 
            20              

<210> 192
<211> 23
<212> PRT
<213> Artificial Sequence


<220> 
<223> C-terminal degron targeted by the CRL2 complex

<400> 192
Ala Thr Gly Ile Asn Gln Leu Ile Ser Arg Trp Gln Lys Cys Val Asp 
1               5                   10                  15      
Cys Asn Gly Ser Tyr Phe Asp 
            20              

<210> 193
<211> 23
<212> PRT
<213> Artificial Sequence


<220> 
<223> C-terminal degron targeted by the CRL2 complex

<400> 193
Leu Ile Gln Gln Leu Gln Gln Gln Ala Leu Ser Glu Pro Ala Val Val 
1               5                   10                  15      
Gln Lys Arg Ala Ser Gly Gln 
            20              

<210> 194
<211> 23
<212> PRT
<213> Artificial Sequence


<220> 
<223> C-terminal degron targeted by the CRL2 complex

<400> 194
Glu Asp Arg Thr Glu Ala Ala Phe Ser Tyr Tyr Glu Phe Leu Leu His 
1               5                   10                  15      
Val Gln Gln Gln Ile Cys Lys 
            20              

<210> 195
<211> 23
<212> PRT
<213> Artificial Sequence


<220> 
<223> C-terminal degron targeted by the CRL2 complex

<400> 195
His Tyr Gly Met Ser Tyr Leu Leu Glu Thr Leu Glu Trp Leu Leu Gln 
1               5                   10                  15      
Lys Asn Pro Gln Leu Gly His 
            20              

<210> 196
<211> 23
<212> PRT
<213> Artificial Sequence


<220> 
<223> C-terminal degron targeted by the CRL2 complex

<400> 196
Cys Gln Pro Ile Ser Phe Ser Gly Phe Gly Ala Glu Asp Asp Asp Leu 
1               5                   10                  15      
Gly Gly Leu Gly Leu Gly Pro 
            20              

<210> 197
<211> 23
<212> PRT
<213> Artificial Sequence


<220> 
<223> C-terminal degron targeted by the CRL2 complex

<400> 197
Arg Asp Ala Trp Thr Arg Arg Leu Arg Arg Leu Gln Arg Arg Glu Arg 
1               5                   10                  15      
Arg Gly Arg Cys Ser Ala Ala 
            20              

<210> 198
<211> 23
<212> PRT
<213> Artificial Sequence


<220> 
<223> C-terminal degron targeted by the CRL2 complex

<400> 198
Ala Glu Val Val Lys Ile Arg Asp Ser Phe Ser Asn Gln Asn Thr Glu 
1               5                   10                  15      
Thr Lys Asp Thr Lys Ser Arg 
            20              

<210> 199
<211> 23
<212> PRT
<213> Artificial Sequence


<220> 
<223> C-terminal degron targeted by the CRL2 complex

<400> 199
Asn Phe Pro Leu Glu Pro Ile Glu Asp Glu Lys Lys Arg His Gln Tyr 
1               5                   10                  15      
Arg Arg Phe Leu Pro Ser Gly 
            20              

<210> 200
<211> 23
<212> PRT
<213> Artificial Sequence


<220> 
<223> C-terminal degron targeted by the CRL2 complex

<400> 200
Phe Gly Gln Lys Ser Gly His His Pro Gly Glu Thr Pro Pro Leu Ile 
1               5                   10                  15      
Thr Pro Gly Ser Ala Gln Ser 
            20              

<210> 201
<211> 23
<212> PRT
<213> Artificial Sequence


<220> 
<223> C-terminal degron targeted by the CRL2 complex

<400> 201
Thr Pro Cys Leu Leu Gly Pro Gly Pro Val Leu Thr Val Leu Ala Leu 
1               5                   10                  15      
Leu Leu Ala Ser Thr Leu Ala 
            20              

<210> 202
<211> 23
<212> PRT
<213> Artificial Sequence


<220> 
<223> C-terminal degron targeted by the CRL2 complex

<400> 202
Arg Gln Trp Cys Ala Ile Ala Ile Leu Phe Ala Val Leu Leu Val Val 
1               5                   10                  15      
Leu Ile Leu Phe Leu Val Leu 
            20              

<210> 203
<211> 23
<212> PRT
<213> Artificial Sequence


<220> 
<223> C-terminal degron targeted by the CRL2 complex

<400> 203
Pro Glu Val Gln Ala Ala Trp Gln Lys Leu Val Ser Ala Val Ala Ile 
1               5                   10                  15      
Ala Leu Ala His Lys Tyr His 
            20              

<210> 204
<211> 23
<212> PRT
<213> Artificial Sequence


<220> 
<223> C-terminal degron targeted by the CRL2 complex

<400> 204
Leu Cys Gly Lys Gly Phe Gln Arg Lys Val Asp Leu Arg Arg His Arg 
1               5                   10                  15      
Glu Thr Gln His Gly Leu Lys 
            20              

<210> 205
<211> 23
<212> PRT
<213> Artificial Sequence


<220> 
<223> C-terminal degron targeted by the CRL2 complex

<400> 205
Ala Cys Ile Ala Gly Glu Arg Arg Tyr Gly Thr Cys Ile Tyr Gln Gly 
1               5                   10                  15      
Arg Leu Trp Ala Phe Cys Cys 
            20              

<210> 206
<211> 23
<212> PRT
<213> Artificial Sequence


<220> 
<223> C-terminal degron targeted by the CRL2 complex

<400> 206
Tyr Ala Gln Met Asp Trp Ala Val Phe Gln Ala Val Lys Val Ala Val 
1               5                   10                  15      
Gly Thr Leu Gln Glu Ala Lys 
            20              

<210> 207
<211> 23
<212> PRT
<213> Artificial Sequence


<220> 
<223> C-terminal degron targeted by the CRL2 complex

<400> 207
Leu Asn Glu Gly Val Ala Asp Tyr Ile Pro Phe Asn His Glu His Ile 
1               5                   10                  15      
Thr Ala Asn Phe Thr Gln Tyr 
            20              

<210> 208
<211> 23
<212> PRT
<213> Artificial Sequence


<220> 
<223> C-terminal degron targeted by the CRL2 complex

<400> 208
Lys Lys Val Ser Lys Ala Ala Ile Leu Ala Arg Ile Lys Arg Thr Gly 
1               5                   10                  15      
Asp Gly Asn Tyr Lys Ser Gly 
            20              

<210> 209
<211> 23
<212> PRT
<213> Artificial Sequence


<220> 
<223> C-terminal degron targeted by the CRL2 complex

<400> 209
Leu Ser Gly Gly Ala Ser Tyr Val Asp Phe Leu Cys His Met His Lys 
1               5                   10                  15      
Glu Ile Arg Gln Leu Leu Ser 
            20              

<210> 210
<211> 23
<212> PRT
<213> Artificial Sequence


<220> 
<223> C-terminal degron targeted by the CRL2 complex

<400> 210
Leu Met Asp Leu Gly Ala Asn Leu Trp Val Thr Lys Leu Trp Lys Phe 
1               5                   10                  15      
Ile Arg Asp Phe Leu Arg Trp 
            20              

<210> 211
<211> 23
<212> PRT
<213> Artificial Sequence


<220> 
<223> C-terminal degron targeted by the CRL2 complex

<400> 211
Ile Leu Gly Trp Ile Cys Phe Cys Phe Ser Phe Ile Ile Gly Val Leu 
1               5                   10                  15      
Tyr Leu Val Leu Arg Lys Lys 
            20              

<210> 212
<211> 23
<212> PRT
<213> Artificial Sequence


<220> 
<223> C-terminal degron targeted by the CRL2 complex

<400> 212
Arg Ala Lys Val Gln Pro Gln Ala Arg Lys Lys Glu Met Glu Met Arg 
1               5                   10                  15      
Gln Leu Gln Arg Gly Pro Ala 
            20              

<210> 213
<211> 23
<212> PRT
<213> Artificial Sequence


<220> 
<223> C-terminal degron targeted by the CRL2 complex

<400> 213
Arg Val Leu Asp Asp Lys Glu Glu Arg Pro Ser Leu Arg Ser Gln Ala 
1               5                   10                  15      
Lys Gly Arg Phe Thr Cys Gly 
            20              

<210> 214
<211> 23
<212> PRT
<213> Artificial Sequence


<220> 
<223> C-terminal degron targeted by the CRL2 complex

<400> 214
Phe Leu Ser Phe Pro Ser Ser Thr Ser Pro Tyr Glu Tyr Val Gln Glu 
1               5                   10                  15      
Gln Arg Cys Tyr Phe Tyr Gln 
            20              

<210> 215
<211> 23
<212> PRT
<213> Artificial Sequence


<220> 
<223> C-terminal degron targeted by the CRL2 complex

<400> 215
Leu Gln Glu Trp Lys Asn Ile Val Ala Ala Phe Glu Ile Ser Glu Ala 
1               5                   10                  15      
Met Ile Thr Tyr Ser Ser Tyr 
            20              

<210> 216
<211> 23
<212> PRT
<213> Artificial Sequence


<220> 
<223> C-terminal degron targeted by the CRL2 complex

<400> 216
Asn Leu Ile Ser Pro Asn Ser Met Ala Lys Asp Ser Trp Glu Asp Trp 
1               5                   10                  15      
Arg Ile Arg Leu Thr Ser Ser 
            20              

<210> 217
<211> 23
<212> PRT
<213> Artificial Sequence


<220> 
<223> C-terminal degron targeted by the CRL2 complex

<400> 217
Asn Arg Glu Val Ile Ser Val Leu Arg Lys Ile Leu Met Lys Glu Ile 
1               5                   10                  15      
Ile Ser Arg Arg Trp Lys Gln 
            20              

<210> 218
<211> 23
<212> PRT
<213> Artificial Sequence


<220> 
<223> C-terminal degron targeted by the CRL2 complex

<400> 218
Ile Asn Gly Gln Gln Gln Gly Pro Thr Ala Phe Arg His Gln Val Gln 
1               5                   10                  15      
Pro Ser Val Thr Ser Leu Phe 
            20              

<210> 219
<211> 23
<212> PRT
<213> Artificial Sequence


<220> 
<223> C-terminal degron targeted by the CRL2 complex

<400> 219
Ala Glu Asp Pro Asn Tyr Leu Pro Leu Pro Glu Glu Gln Pro Gly Pro 
1               5                   10                  15      
His Leu Pro Pro Pro Gln Gln 
            20              

<210> 220
<211> 23
<212> PRT
<213> Artificial Sequence


<220> 
<223> C-terminal degron targeted by the CRL2 complex

<400> 220
Thr Gly Trp Leu Glu Asp Phe Leu Met Gly Met Asp Ser Thr Leu Glu 
1               5                   10                  15      
Pro Ser Ala Gly Gly Thr Val 
            20              

<210> 221
<211> 23
<212> PRT
<213> Artificial Sequence


<220> 
<223> C-terminal degron targeted by the CRL2 complex

<400> 221
Arg Tyr Ala Met Val Tyr Gly Tyr Asn Ala Ala Tyr Asn Arg Tyr Phe 
1               5                   10                  15      
Arg Lys Arg Arg Gly Thr Lys 
            20              

<210> 222
<211> 23
<212> PRT
<213> Artificial Sequence


<220> 
<223> C-terminal degron targeted by the CRL2 complex

<400> 222
Asp Gly Trp Ile Arg Val Ser Ser Asp Asn Val Ala Asp Leu His Glu 
1               5                   10                  15      
Lys Tyr Ser Gly Ser Thr Pro 
            20              

<210> 223
<211> 23
<212> PRT
<213> Artificial Sequence


<220> 
<223> C-terminal degron targeted by the CRL2 complex

<400> 223
Thr Arg Val Ala Leu Tyr Val Asp Trp Ile Arg Ser Thr Leu Arg Arg 
1               5                   10                  15      
Val Glu Ala Lys Gly Arg Pro 
            20              

<210> 224
<211> 23
<212> PRT
<213> Artificial Sequence


<220> 
<223> C-terminal degron targeted by the CRL2 complex

<400> 224
Leu Pro Asn Arg Pro Gly Val Tyr Ala Arg Val Ser Arg Phe Thr Glu 
1               5                   10                  15      
Trp Ile Gln Ser Phe Leu His 
            20              

<210> 225
<211> 23
<212> PRT
<213> Artificial Sequence


<220> 
<223> C-terminal degron targeted by the CRL2 complex

<400> 225
Glu Pro Lys Lys Lys Lys Tyr Ala Lys Glu Ala Trp Pro Gly Lys Lys 
1               5                   10                  15      
Pro Thr Pro Ser Leu Leu Ile 
            20              

<210> 226
<211> 23
<212> PRT
<213> Artificial Sequence


<220> 
<223> C-terminal degron targeted by the CRL2 complex

<400> 226
Arg Glu Leu Asp Leu Ala Gln Glu Lys Thr Gly Trp Phe Ala Leu Gly 
1               5                   10                  15      
Ser Arg Ser His Gly Thr Leu 
            20              

<210> 227
<211> 23
<212> PRT
<213> Artificial Sequence


<220> 
<223> C-terminal degron targeted by the CRL2 complex

<400> 227
Asp Cys Ala Cys Arg Asp Pro Gln Ala Gln Glu His Ser Arg Lys Asp 
1               5                   10                  15      
Leu Arg Gly Tyr Ser His Gly 
            20              

<210> 228
<211> 23
<212> PRT
<213> Artificial Sequence


<220> 
<223> C-terminal degron targeted by the CRL2 complex

<400> 228
Cys Asp Tyr Thr Asn Pro Cys Thr Lys Ser Trp Phe Trp Thr Arg Leu 
1               5                   10                  15      
Ala Lys Ala Leu Ser Leu Pro 
            20              

<210> 229
<211> 23
<212> PRT
<213> Artificial Sequence


<220> 
<223> C-terminal degron targeted by the CRL2 complex

<400> 229
Thr Val Cys Gly Leu Pro Thr Gly Thr Ser Arg Arg Ala Arg Arg Ser 
1               5                   10                  15      
Pro Arg His Leu Gly Ser Gly 
            20              

<210> 230
<211> 23
<212> PRT
<213> Artificial Sequence


<220> 
<223> C-terminal degron targeted by the CRL2 complex

<400> 230
Pro Val Leu Pro Ile Pro Pro Val Gly Leu Tyr Ala Thr Pro Val Gly 
1               5                   10                  15      
Tyr Gly Met Tyr His Leu Ser 
            20              

<210> 231
<211> 23
<212> PRT
<213> Artificial Sequence


<220> 
<223> C-terminal degron targeted by the CRL2 complex

<400> 231
Arg Leu Ala Val Val Gln Cys Val Ala Val Ile Trp Asn Ser Tyr Leu 
1               5                   10                  15      
Ser Trp Lys Ala His Arg Leu 
            20              

<210> 232
<211> 23
<212> PRT
<213> Artificial Sequence


<220> 
<223> C-terminal degron targeted by the CRL2 complex

<400> 232
Phe Asp Tyr Leu Gln Ser Val Leu Asp Asp Phe Tyr Thr Ala Thr Glu 
1               5                   10                  15      
Gly Gln Tyr Gln Gln Gln Pro 
            20              

<210> 233
<211> 23
<212> PRT
<213> Artificial Sequence


<220> 
<223> C-terminal degron targeted by the CRL2 complex

<400> 233
Thr Leu Cys Gln Thr Lys Arg Arg Pro Ala Ser Glu Gln Arg Gly Arg 
1               5                   10                  15      
Thr Val Pro Ala Gly Arg Arg 
            20              

<210> 234
<211> 23
<212> PRT
<213> Artificial Sequence


<220> 
<223> C-terminal degron targeted by the CRL2 complex

<400> 234
Ala Thr Trp Leu Asp Ser Leu Leu Thr Pro Val Arg Leu Pro Ser Ile 
1               5                   10                  15      
Gln Ala Ile Pro Cys Ala Pro 
            20              

<210> 235
<211> 23
<212> PRT
<213> Artificial Sequence


<220> 
<223> C-terminal degron targeted by the CRL2 complex

<400> 235
Glu Ala Leu Pro Val Thr Trp Gly Thr Ser Ser Arg Asp Glu Asp Leu 
1               5                   10                  15      
Glu Asn Cys Ser His His Leu 
            20              

<210> 236
<211> 23
<212> PRT
<213> Artificial Sequence


<220> 
<223> C-terminal degron targeted by the CRL2 complex

<400> 236
Gly Thr Asp Leu Met Asn Phe Leu Lys Thr Val Arg Ser Thr Thr Glu 
1               5                   10                  15      
Lys Ser Leu Leu Lys Glu Gly 
            20              

<210> 237
<211> 23
<212> PRT
<213> Artificial Sequence


<220> 
<223> C-terminal degron targeted by the CRL2 complex

<400> 237
His Ala Lys Arg Val Thr Ile Met Pro Lys Asp Ile Gln Leu Ala Arg 
1               5                   10                  15      
Arg Ile Arg Gly Glu Arg Ala 
            20              

<210> 238
<211> 23
<212> PRT
<213> Artificial Sequence


<220> 
<223> C-terminal degron targeted by the CRL2 complex

<400> 238
Glu Pro Gly Gln Arg Pro Ser Phe Ser Thr Ile Tyr Gln Glu Leu Gln 
1               5                   10                  15      
Ser Ile Arg Lys Arg His Arg 
            20              

<210> 239
<211> 23
<212> PRT
<213> Artificial Sequence


<220> 
<223> C-terminal degron targeted by the CRL2 complex

<400> 239
Ser Phe Ser Ala Ser Thr Gly Leu Ser Asp Met Thr Ala Thr Phe Ser 
1               5                   10                  15      
Pro Arg Thr Ile Glu Ile Cys 
            20              

<210> 240
<211> 23
<212> PRT
<213> Artificial Sequence


<220> 
<223> C-terminal degron targeted by the CRL2 complex

<400> 240
Leu Phe Ala Lys Arg Gln Gln Glu Ala Met Arg Glu Pro Arg Ser Thr 
1               5                   10                  15      
His Ser Arg Trp Arg Lys Arg 
            20              

<210> 241
<211> 23
<212> PRT
<213> Artificial Sequence


<220> 
<223> C-terminal degron targeted by the CRL2 complex

<400> 241
Lys Pro Thr Cys Arg Glu Thr Met Leu Ala Val Lys Phe Ile Ala Lys 
1               5                   10                  15      
Tyr Ile Leu Lys His Thr Ser 
            20              

<210> 242
<211> 23
<212> PRT
<213> Artificial Sequence


<220> 
<223> C-terminal degron targeted by the CRL2 complex

<400> 242
Glu Leu Glu Asn Leu Ala Ala Met Asp Leu Glu Leu Gln Lys Ile Ala 
1               5                   10                  15      
Glu Lys Phe Ser Gln Arg Gly 
            20              

<210> 243
<211> 23
<212> PRT
<213> Artificial Sequence


<220> 
<223> C-terminal degron targeted by the CRL2 complex

<400> 243
Leu Gly His Val Lys His Lys Leu Val Cys Ser Pro Asp Phe Glu Ser 
1               5                   10                  15      
Leu Leu Asp His Lys His Arg 
            20              

<210> 244
<211> 23
<212> PRT
<213> Artificial Sequence


<220> 
<223> C-terminal degron targeted by the CRL2 complex

<400> 244
Pro Thr Lys Asp Arg Leu Glu Gly Leu Leu Ala Phe Lys Glu Lys Arg 
1               5                   10                  15      
Pro Pro Arg Tyr Lys Gly Glu 
            20              

<210> 245
<211> 23
<212> PRT
<213> Artificial Sequence


<220> 
<223> C-terminal degron targeted by the CRL2 complex

<400> 245
Cys Gln Arg Pro Tyr Arg Trp Val Cys Glu Thr Glu Leu Asp Lys Ala 
1               5                   10                  15      
Ser Gln Glu Pro Pro Leu Leu 
            20              

<210> 246
<211> 23
<212> PRT
<213> Artificial Sequence


<220> 
<223> C-terminal degron targeted by the CRL2 complex

<400> 246
Ile Tyr Leu Leu Ala Val Leu Ala Tyr Ser Ile Thr Leu Val Met Leu 
1               5                   10                  15      
Trp Ser Ile Trp Gln Tyr Ala 
            20              

<210> 247
<211> 23
<212> PRT
<213> Artificial Sequence


<220> 
<223> C-terminal degron targeted by the CRL2 complex

<400> 247
Gly Phe Asn Leu Val Tyr Trp Val Val Tyr Leu Ser Lys Asp Thr Met 
1               5                   10                  15      
Glu Val Ser Ser Ser Val Glu 
            20              

<210> 248
<211> 23
<212> PRT
<213> Artificial Sequence


<220> 
<223> C-terminal degron targeted by the CRL2 complex

<400> 248
Gly Leu Leu Leu Thr Glu Lys Pro Ile Val Leu Lys Ala Glu Ser Arg 
1               5                   10                  15      
Asp Glu Thr Val Ser Gly Ala 
            20              

<210> 249
<211> 23
<212> PRT
<213> Artificial Sequence


<220> 
<223> C-terminal degron targeted by the CRL2 complex

<400> 249
Asp Cys Gly His Thr Val Ser Ile Ser Lys Gly Leu Leu Thr Glu Glu 
1               5                   10                  15      
Ala Thr Arg Gly Tyr Val Lys 
            20              

<210> 250
<211> 23
<212> PRT
<213> Artificial Sequence


<220> 
<223> C-terminal degron targeted by the CRL2 complex

<400> 250
Glu Lys Gly Asp Lys Gly Asp Gln Val Tyr Ala Gly Arg Arg Arg Arg 
1               5                   10                  15      
Arg Ser Ile Ala Val Lys Pro 
            20              

<210> 251
<211> 23
<212> PRT
<213> Artificial Sequence


<220> 
<223> C-terminal degron targeted by the CRL2 complex

<400> 251
Lys Lys Leu Gly Lys Gly Asn Gln Val Glu Ala Glu Gly Ala Gly Ala 
1               5                   10                  15      
Gly Gln Ala Pro Glu Ala Gly 
            20              

<210> 252
<211> 23
<212> PRT
<213> Artificial Sequence


<220> 
<223> C-terminal degron targeted by the CRL2 complex

<400> 252
Pro Ser Ser Leu Ala Leu Glu Thr Ile Gln Ile Pro Ala Ser Leu Gly 
1               5                   10                  15      
Leu Gly Phe Ile Ser Arg Val 
            20              

<210> 253
<211> 23
<212> PRT
<213> Artificial Sequence


<220> 
<223> C-terminal degron targeted by the CRL2 complex

<400> 253
Asp Ala Thr Gln Leu Gly Phe Gln Pro Leu Met Ser Asp Leu Gly Ser 
1               5                   10                  15      
Thr Gly Ser Thr Glu Gly Ala 
            20              

<210> 254
<211> 23
<212> PRT
<213> Artificial Sequence


<220> 
<223> C-terminal degron targeted by the CRL2 complex

<400> 254
Asp Gly Ser Gly Lys Gly Ala Ala Leu Ile Thr Ala Val Ala Cys Arg 
1               5                   10                  15      
Ile Arg Glu Ala Gly Gln Arg 
            20              

<210> 255
<211> 23
<212> PRT
<213> Artificial Sequence


<220> 
<223> C-terminal degron targeted by the CRL2 complex

<400> 255
Cys Arg Lys Asp Gln Gln Arg Leu Lys Gln Pro Met Phe Tyr Ser Phe 
1               5                   10                  15      
Leu Ser Ser Tyr Ala Ala Gly 
            20              

<210> 256
<211> 23
<212> PRT
<213> Artificial Sequence


<220> 
<223> C-terminal degron targeted by the CRL4A complex

<400> 256
Thr Leu Trp Pro Arg Asp Ser Asp Ala Phe Ser Thr Leu Met Pro Ser 
1               5                   10                  15      
Ser Val Lys Ala Leu Met Leu 
            20              

<210> 257
<211> 23
<212> PRT
<213> Artificial Sequence


<220> 
<223> C-terminal degron targeted by the CRL4A complex

<400> 257
Lys Lys Tyr Gly Glu Phe Phe Pro Val Pro Glu Ser Ile Leu Ser Met 
1               5                   10                  15      
Cys Val Leu Val Phe Leu Thr 
            20              

<210> 258
<211> 23
<212> PRT
<213> Artificial Sequence


<220> 
<223> C-terminal degron targeted by the CRL4A complex

<400> 258
Ala Pro Thr Ala Ala Leu Pro Pro Arg Ala Arg Cys Trp Ala Gly Thr 
1               5                   10                  15      
Cys Arg Pro Arg Arg Arg Cys 
            20              

<210> 259
<211> 23
<212> PRT
<213> Artificial Sequence


<220> 
<223> C-terminal degron targeted by the CRL4A complex

<400> 259
Lys Glu Pro Arg Lys Tyr Glu Asn Ala Ile Asp Gln Trp Leu Lys Thr 
1               5                   10                  15      
His Met Asn Pro Arg Ala Val 
            20              

<210> 260
<211> 23
<212> PRT
<213> Artificial Sequence


<220> 
<223> C-terminal degron targeted by the CRL4A complex

<400> 260
Glu Ser Gln Asp Ala Pro Ser Cys Ser Thr His Pro Cys Asp Ser Ser 
1               5                   10                  15      
Leu Pro Cys Asp Ser Asp Leu 
            20              

<210> 261
<211> 23
<212> PRT
<213> Artificial Sequence


<220> 
<223> C-terminal degron targeted by the CRL4A complex

<400> 261
Leu His Leu Arg Gln Lys His Gly Ala Ala Thr Asn Thr Lys Val His 
1               5                   10                  15      
Tyr His Ile Leu Gly Gly Pro 
            20              

<210> 262
<211> 23
<212> PRT
<213> Artificial Sequence


<220> 
<223> C-terminal degron targeted by the CRL4A complex

<400> 262
Tyr Gly His Gly Tyr Gly Ser Arg Phe Phe Cys Gly Cys Gly Tyr Gly 
1               5                   10                  15      
Cys Gly Ser Gly Tyr Tyr Tyr 
            20              

<210> 263
<211> 23
<212> PRT
<213> Artificial Sequence


<220> 
<223> C-terminal degron targeted by the CRL4A complex

<400> 263
Val Asn Gln Ile Lys Asp Gln Ile Lys Leu Gln Leu Tyr Asn Gln Gln 
1               5                   10                  15      
His Arg Ala Asp Pro Trp Tyr 
            20              

<210> 264
<211> 23
<212> PRT
<213> Artificial Sequence


<220> 
<223> C-terminal degron targeted by the CRL4A complex

<400> 264
Gln Ser Pro Gly Ile Leu Arg Leu Gln Phe Gln Val Leu Val Gln His 
1               5                   10                  15      
Pro Gln Asn Glu Ser Ser Glu 
            20              

<210> 265
<211> 23
<212> PRT
<213> Artificial Sequence


<220> 
<223> C-terminal degron targeted by the CRL4A complex

<400> 265
Lys Gln Thr Phe Leu Ser Val Leu Trp Gln Val Thr Cys Trp Ala Lys 
1               5                   10                  15      
Gly Gln Asn Gln Ser Thr Pro 
            20              

<210> 266
<211> 23
<212> PRT
<213> Artificial Sequence


<220> 
<223> C-terminal degron targeted by the CRL4A complex

<400> 266
Pro Gly Leu Arg Arg Ala Trp Lys Arg Phe Gln His Gln Val Pro Leu 
1               5                   10                  15      
Tyr Leu Lys Gly Gln Thr Leu 
            20              

<210> 267
<211> 23
<212> PRT
<213> Artificial Sequence


<220> 
<223> C-terminal degron targeted by the CRL4A complex

<400> 267
Glu Gly Met Val Glu Gly Ala Lys Arg Arg Asp Arg Arg Lys Thr Arg 
1               5                   10                  15      
Arg Pro Ile Gln Pro Ser Trp 
            20              

<210> 268
<211> 23
<212> PRT
<213> Artificial Sequence


<220> 
<223> C-terminal degron targeted by the CRL4A complex

<400> 268
Leu Asn Cys Pro Phe Pro Asn Cys Thr Pro Lys Gly Ser Arg Arg Ala 
1               5                   10                  15      
Gly Ala Leu Ala Pro Pro Gly 
            20              

<210> 269
<211> 23
<212> PRT
<213> Artificial Sequence


<220> 
<223> C-terminal degron targeted by the CRL4A complex

<400> 269
Ser Arg Ser Arg Leu Cys Ser Ile Cys Cys Arg Arg Asn Arg Arg Phe 
1               5                   10                  15      
Phe His Asp Phe Arg Lys Met 
            20              

<210> 270
<211> 23
<212> PRT
<213> Artificial Sequence


<220> 
<223> C-terminal degron targeted by the CRL4A complex

<400> 270
Pro Gly Lys Pro Val Val Ala Thr Phe Ser Glu Ser Arg Ile Leu Glu 
1               5                   10                  15      
Lys Gln Asp Lys Arg Ala Ser 
            20              

<210> 271
<211> 23
<212> PRT
<213> Artificial Sequence


<220> 
<223> C-terminal degron targeted by the CRL4A complex

<400> 271
Pro Gln Val Asp Glu Leu Asp Arg Leu Asn Ala Pro Leu Ser Gln Met 
1               5                   10                  15      
Ala Ser Asn Asp Phe Gln Asp 
            20              

<210> 272
<211> 23
<212> PRT
<213> Artificial Sequence


<220> 
<223> C-terminal degron targeted by the CRL4A complex

<400> 272
Ile Pro Glu Thr Glu Thr Leu Glu Ile Thr Met Thr Met Lys Arg Glu 
1               5                   10                  15      
Leu Asp Ile Ala Asn Phe Phe 
            20              

<210> 273
<211> 23
<212> PRT
<213> Artificial Sequence


<220> 
<223> C-terminal degron targeted by the CRL4A complex

<400> 273
Ser Glu Lys Ala Pro Leu Arg Lys Thr Ser Glu Ala Ala Val Lys Glu 
1               5                   10                  15      
Gly Lys Thr Glu Lys Thr Asp 
            20              

<210> 274
<211> 23
<212> PRT
<213> Artificial Sequence


<220> 
<223> C-terminal degron targeted by the CRL4A complex

<400> 274
Gly Ala Pro Cys Gln Ser Ser Pro Gln Leu Trp Gly Pro Met Ala Ile 
1               5                   10                  15      
Phe Leu Leu Ala Leu Gln Arg 
            20              

<210> 275
<211> 23
<212> PRT
<213> Artificial Sequence


<220> 
<223> C-terminal degron targeted by the CRL4A complex

<400> 275
Ile Leu Met Val Tyr Gly Phe Cys Gln Cys Val Cys His Glu Phe Leu 
1               5                   10                  15      
Asp Cys Met Ala Pro Pro Ser 
            20              

<210> 276
<211> 23
<212> PRT
<213> Artificial Sequence


<220> 
<223> C-terminal degron targeted by the CRL4A complex

<400> 276
Phe Lys His Leu Ser Ala Ala Cys Gln Ser Asn Lys Gln Gln Val Pro 
1               5                   10                  15      
Thr Asn Leu Met Thr Phe Glu 
            20              

<210> 277
<211> 23
<212> PRT
<213> Artificial Sequence


<220> 
<223> C-terminal degron targeted by the CRL4A complex

<400> 277
Ser Asp Lys Gln Val Gln Val Cys Val Arg Met Leu Lys Leu Asp Thr 
1               5                   10                  15      
Arg Ile Lys Thr Arg Lys Asn 
            20              

<210> 278
<211> 23
<212> PRT
<213> Artificial Sequence


<220> 
<223> C-terminal degron targeted by the CRL4A complex

<400> 278
Pro Glu Leu Leu Ala Met Trp Gly Leu Val His Ser Asn Leu Thr Cys 
1               5                   10                  15      
Ser Arg Lys Leu Gln Val Leu 
            20              

<210> 279
<211> 23
<212> PRT
<213> Artificial Sequence


<220> 
<223> C-terminal degron targeted by the CRL4A complex

<400> 279
Ala Leu Ser Leu Glu Glu Lys Leu Ala Arg Arg Gln Ala Ser Gln Val 
1               5                   10                  15      
Phe Thr Ala Glu Lys Ile Pro 
            20              

<210> 280
<211> 23
<212> PRT
<213> Artificial Sequence


<220> 
<223> C-terminal degron targeted by the CRL4A complex

<400> 280
Val Gly Cys Gly Lys Ser Phe Arg His Ser Ser Ala Leu Leu Arg His 
1               5                   10                  15      
Gln Arg Leu His Ala Gly Glu 
            20              

<210> 281
<211> 23
<212> PRT
<213> Artificial Sequence


<220> 
<223> C-terminal degron targeted by the CRL4A complex

<400> 281
Ser Arg Ile Ser His Leu Val Leu Pro Val Gln Pro Val Ser Ser Ile 
1               5                   10                  15      
Glu Glu Gln Gly Cys Leu Phe 
            20              

<210> 282
<211> 23
<212> PRT
<213> Artificial Sequence


<220> 
<223> C-terminal degron targeted by the CRL4A complex

<400> 282
Leu Ser Lys Thr Tyr Lys Ser His Leu Met Ser Thr Val Arg Ser Pro 
1               5                   10                  15      
Thr Ala Ser Glu Ser Arg Asn 
            20              

<210> 283
<211> 23
<212> PRT
<213> Artificial Sequence


<220> 
<223> C-terminal degron targeted by the CRL4A complex

<400> 283
Thr Ile Lys Val Tyr Asp Tyr Tyr Leu Pro Asp Glu Gln Ala Thr Ile 
1               5                   10                  15      
Gln Tyr Ser Asp Pro Cys Glu 
            20              

<210> 284
<211> 23
<212> PRT
<213> Artificial Sequence


<220> 
<223> C-terminal degron targeted by the CRL4A complex

<400> 284
Asp Trp Ser Ser Arg Tyr Ala Val Gly Leu Asp Gly Gln Ala Pro Gly 
1               5                   10                  15      
Gln Asp Cys Val Trp Gln Gly 
            20              

<210> 285
<211> 23
<212> PRT
<213> Artificial Sequence


<220> 
<223> C-terminal degron targeted by the CRL4A complex

<400> 285
Arg Leu Lys Ala Tyr Val Leu Tyr Lys Glu Tyr Asp Leu Tyr Gly Gln 
1               5                   10                  15      
Gly Ile Phe Thr Gly Thr Trp 
            20              

<210> 286
<211> 23
<212> PRT
<213> Artificial Sequence


<220> 
<223> C-terminal degron targeted by the CRL4A complex

<400> 286
Thr Leu Pro Gln Phe Tyr Ser Phe Leu His Glu Met Glu Arg Val Arg 
1               5                   10                  15      
Thr Ser Met Glu Cys Phe Cys 
            20              

<210> 287
<211> 23
<212> PRT
<213> Artificial Sequence


<220> 
<223> C-terminal degron targeted by the CRL4A complex

<400> 287
Phe Phe Ser Phe Leu Glu Asp Asp Ser Leu Tyr Leu Leu Lys Glu Ser 
1               5                   10                  15      
Glu Asp Lys Phe Lys Leu Asp 
            20              

<210> 288
<211> 23
<212> PRT
<213> Artificial Sequence


<220> 
<223> C-terminal degron targeted by the CRL4A complex

<400> 288
Ile Pro Leu Trp Ala Leu Leu Ala Gly Ala Leu Thr Glu Leu Gly Tyr 
1               5                   10                  15      
Asn Val Phe Phe Val Arg Asp 
            20              

<210> 289
<211> 23
<212> PRT
<213> Artificial Sequence


<220> 
<223> C-terminal degron targeted by the CRL4A complex

<400> 289
Leu Ser Leu Leu Ser Thr Leu Ala Ala Ser Thr Gly Pro Gln Leu Ala 
1               5                   10                  15      
Pro Pro Ile Gly Asn Ser Ile 
            20              

<210> 290
<211> 23
<212> PRT
<213> Artificial Sequence


<220> 
<223> C-terminal degron targeted by the CRL4A complex

<400> 290
Phe Lys Gln Arg Leu Ala Lys Trp Arg Arg Ser Glu Gly Leu Pro Ser 
1               5                   10                  15      
Glu Cys Arg Ser Val Thr Asp 
            20              

<210> 291
<211> 23
<212> PRT
<213> Artificial Sequence


<220> 
<223> C-terminal degron targeted by the CRL4A complex

<400> 291
Ser Asp Ala Gly Cys Ile Phe Ile Glu Glu Asn Phe Ser Leu Lys Cys 
1               5                   10                  15      
Pro Lys His Lys Arg Leu Pro 
            20              

<210> 292
<211> 23
<212> PRT
<213> Artificial Sequence


<220> 
<223> C-terminal degron targeted by the CRL4A complex

<400> 292
Gln Ala Asn Asn Gln Tyr Ile Pro Lys Pro Lys Pro Ala Arg Ile Lys 
1               5                   10                  15      
Lys Gly Arg Thr Arg His Ser 
            20              

<210> 293
<211> 23
<212> PRT
<213> Artificial Sequence


<220> 
<223> C-terminal degron targeted by the CRL4A complex

<400> 293
Pro Asp Gly Leu Glu Glu Gly Ala Arg Gly Ser Gln Glu Gly Ser Glu 
1               5                   10                  15      
Leu Asn Cys Ala Ser Leu Ser 
            20              

<210> 294
<211> 23
<212> PRT
<213> Artificial Sequence


<220> 
<223> C-terminal degron targeted by the CRL4A complex

<400> 294
Leu Gln Leu Cys Gln Gln Leu Lys Asp Lys Ile Ser Val Phe Ser Ser 
1               5                   10                  15      
Tyr Trp Ser Tyr Arg Pro Phe 
            20              

<210> 295
<211> 23
<212> PRT
<213> Artificial Sequence


<220> 
<223> C-terminal degron targeted by the CRL4A complex

<400> 295
Val Arg Ala Glu Ile Met Arg Ser Leu Ser Leu Ser Thr Asn Leu Gln 
1               5                   10                  15      
Glu Arg Leu Arg Arg Lys Glu 
            20              

<210> 296
<211> 23
<212> PRT
<213> Artificial Sequence


<220> 
<223> C-terminal degron targeted by the CRL4A complex

<400> 296
Val Val Asp Trp Thr Ser Gln Tyr Thr Met Val Phe His Pro Ala Arg 
1               5                   10                  15      
Glu Lys Val Leu Arg Ser Val 
            20              

<210> 297
<211> 23
<212> PRT
<213> Artificial Sequence


<220> 
<223> C-terminal degron targeted by the CRL4A complex

<400> 297
Asp Asn Ser Cys Gly Thr Leu Asn Ser Thr Leu Trp Trp Glu Arg Thr 
1               5                   10                  15      
Gln Glu Asp Arg Val Val Phe 
            20              

<210> 298
<211> 23
<212> PRT
<213> Artificial Sequence


<220> 
<223> C-terminal degron targeted by the CRL4A complex

<400> 298
Val Asp Pro Thr Gln Glu Cys Phe Ile Pro Gln Ala Lys Leu Ser Pro 
1               5                   10                  15      
Gln Gln Asp Ala Gly Gly Val 
            20              

<210> 299
<211> 23
<212> PRT
<213> Artificial Sequence


<220> 
<223> C-terminal degron targeted by the CRL4A complex

<400> 299
Ser Leu Thr Ala Leu Leu Leu Ile Ala Val Leu Leu Gly Pro Ile Tyr 
1               5                   10                  15      
Val Pro Trp Lys Gln Lys Thr 
            20              

<210> 300
<211> 23
<212> PRT
<213> Artificial Sequence


<220> 
<223> C-terminal degron targeted by the CRL4A complex

<400> 300
Asp Gln Asn Gln Lys Asn Leu Gly Gly Met Gln Ser Met Met Tyr Arg 
1               5                   10                  15      
Asp Lys Leu Met Thr Ala Leu 
            20              

<210> 301
<211> 23
<212> PRT
<213> Artificial Sequence


<220> 
<223> C-terminal degron targeted by the CRL4A complex

<400> 301
Leu Ile Arg Met Cys Ser His Gly Glu Gly Lys Ile Asn Tyr Tyr Asn 
1               5                   10                  15      
Phe Val Arg Ala Phe Ser Asn 
            20              

<210> 302
<211> 23
<212> PRT
<213> Artificial Sequence


<220> 
<223> C-terminal degron targeted by the CRL4A complex

<400> 302
Leu Lys Val Ser Arg Asp Met Met Lys Gln Leu Met Trp Leu Ser Ser 
1               5                   10                  15      
His Gln Glu Gly Pro Arg Ser 
            20              

<210> 303
<211> 23
<212> PRT
<213> Artificial Sequence


<220> 
<223> C-terminal degron targeted by the CRL4A complex

<400> 303
Leu Pro Pro His Pro Cys Arg Ile His Val Arg Pro Gly Gly Leu Val 
1               5                   10                  15      
Arg Thr Val Thr Val Asn Glu 
            20              

<210> 304
<211> 23
<212> PRT
<213> Artificial Sequence


<220> 
<223> C-terminal degron targeted by the CRL4A complex

<400> 304
Ala Ala Ile Lys Glu Ser Lys Ile Phe Ser Glu Thr Cys Ser Ser Val 
1               5                   10                  15      
Phe Lys Trp Ile Cys Gln Tyr 
            20              

<210> 305
<211> 23
<212> PRT
<213> Artificial Sequence


<220> 
<223> C-terminal degron targeted by the CRL4A complex

<400> 305
Leu Val Val Lys Ser Asn Leu Asn Pro Asn Ala Lys Glu Phe Val Pro 
1               5                   10                  15      
Gly Val Lys Tyr Gly Asn Ile 
            20              

<210> 306
<211> 23
<212> PRT
<213> Artificial Sequence


<220> 
<223> C-terminal degron targeted by the CRL4A complex

<400> 306
Thr His Ser Ser Ala Lys Arg Ser Lys Glu Glu Ser Ala His Trp Val 
1               5                   10                  15      
Thr His Thr Ser Tyr Cys Phe 
            20              

<210> 307
<211> 23
<212> PRT
<213> Artificial Sequence


<220> 
<223> C-terminal degron targeted by the CRL4A complex

<400> 307
Gln Cys His Leu Cys Asp Arg Ala Phe Ser Arg Ser Asp His Leu Ala 
1               5                   10                  15      
Leu His Met Lys Arg His Met 
            20              

<210> 308
<211> 23
<212> PRT
<213> Artificial Sequence


<220> 
<223> C-terminal degron targeted by the CRL4A complex

<400> 308
Met Ala Val Val Leu Asn Gly Gly Thr Ile Pro Thr Ala Pro Pro Ser 
1               5                   10                  15      
His Thr Gly Arg His Leu Trp 
            20              

<210> 309
<211> 23
<212> PRT
<213> Artificial Sequence


<220> 
<223> C-terminal degron targeted by the CRL4A complex

<400> 309
Pro Met Ala Ile Val Val Phe His Gln Ala Asp Ile Gly Glu Tyr Val 
1               5                   10                  15      
Arg His Glu Glu Thr Leu Thr 
            20              

<210> 310
<211> 23
<212> PRT
<213> Artificial Sequence


<220> 
<223> C-terminal degron targeted by the CRL4A complex

<400> 310
Asn Glu Arg Thr Thr Phe Trp His Gly Ser Asn Glu Gly Ala Val Ser 
1               5                   10                  15      
Leu Leu Leu Arg Tyr Cys Ala 
            20              

<210> 311
<211> 23
<212> PRT
<213> Artificial Sequence


<220> 
<223> C-terminal degron targeted by the CRL4A complex

<400> 311
Leu Thr Asn Trp Gly His Pro Glu Tyr Thr Cys Ile Tyr Arg Phe Arg 
1               5                   10                  15      
Val His Gly Glu Pro Ala His 
            20              

<210> 312
<211> 23
<212> PRT
<213> Artificial Sequence


<220> 
<223> C-terminal degron targeted by the CRL4A complex

<400> 312
Cys Gly Ala Phe Cys His Asp Asp Cys Ile Gly Pro Ser Lys Leu Cys 
1               5                   10                  15      
Val Leu Cys Leu Val Val Arg 
            20              

<210> 313
<211> 23
<212> PRT
<213> Artificial Sequence


<220> 
<223> C-terminal degron targeted by the CRL4A complex

<400> 313
Leu Asp Pro Asp Gln Pro Ala Gly Ala Ile Val Thr Phe Ile Thr Lys 
1               5                   10                  15      
Val Leu Leu Gly Gln Arg Lys 
            20              

<210> 314
<211> 23
<212> PRT
<213> Artificial Sequence


<220> 
<223> C-terminal degron targeted by the CRL4A complex

<400> 314
Asn Ile Ala Ala Ile Ser Leu Ala Ile Asn Tyr Pro Asn Lys Ala Thr 
1               5                   10                  15      
Arg Leu Trp Asn Val Glu Cys 
            20              

<210> 315
<211> 23
<212> PRT
<213> Artificial Sequence


<220> 
<223> C-terminal degron targeted by the CRL4A complex

<400> 315
Cys Ser Ser Asp Ser Thr Asn Gly Thr Gly Val Gln Gly Gly Gln Ile 
1               5                   10                  15      
Pro Glu Leu Ile Phe Tyr Ala 
            20              

<210> 316
<211> 23
<212> PRT
<213> Artificial Sequence


<220> 
<223> C-terminal degron targeted by the CRL4A complex

<400> 316
Phe Leu Val Tyr Phe Asn Ile Ile Ile Met Trp Asp Ser Lys Ser Gly 
1               5                   10                  15      
Arg Asn Gln Lys Lys Ile Ser 
            20              

<210> 317
<211> 23
<212> PRT
<213> Artificial Sequence


<220> 
<223> C-terminal degron targeted by the CRL4A complex

<400> 317
Ala Ser Ser Leu Gly Gln Ile Pro Met Gln Arg Gln Pro Ile Gln Lys 
1               5                   10                  15      
Asp Ser Thr Thr Leu Glu Asp 
            20              

<210> 318
<211> 23
<212> PRT
<213> Artificial Sequence


<220> 
<223> C-terminal degron targeted by the CRL4A complex

<400> 318
Lys Ala Thr Leu Val Leu Asn Ser Leu Gln Asp Phe Gln Pro Glu Leu 
1               5                   10                  15      
Phe Gly Leu Pro Ser Tyr Glu 
            20              

<210> 319
<211> 23
<212> PRT
<213> Artificial Sequence


<220> 
<223> C-terminal degron targeted by the CRL4A complex

<400> 319
Arg Gly Glu Glu Thr Ala Thr Trp Ile Ser Ser Pro Ser Val Ala Gln 
1               5                   10                  15      
Lys Ala Ala Ala Ser Glu Asp 
            20              

<210> 320
<211> 23
<212> PRT
<213> Artificial Sequence


<220> 
<223> C-terminal degron targeted by the CRL4A complex

<400> 320
Thr Leu Leu Ser Ile Pro Glu Val Val Arg Gly Cys Lys Glu Leu Gln 
1               5                   10                  15      
Gly Leu Leu Glu Phe Leu Ser 
            20              

<210> 321
<211> 23
<212> PRT
<213> Artificial Sequence


<220> 
<223> C-terminal degron targeted by the CRL4A complex

<400> 321
Leu Thr Asp Asp Val Ser Leu Gln Val Phe Met Asp His Leu Lys Lys 
1               5                   10                  15      
Leu Ala Val Ser Ser Ala Cys 
            20              

<210> 322
<211> 23
<212> PRT
<213> Artificial Sequence


<220> 
<223> C-terminal degron targeted by the CRL4A complex

<400> 322
Pro Leu Ala Ser Leu Ser Gly Ser Gln Ala Leu Leu Trp Pro Gly Cys 
1               5                   10                  15      
Pro Leu Leu Tyr Gly Leu Glu 
            20              

<210> 323
<211> 23
<212> PRT
<213> Artificial Sequence


<220> 
<223> C-terminal degron targeted by the CRL4A complex

<400> 323
Pro Gly Val Tyr Ile Leu Leu Ser Lys Lys His Leu Asn Trp Ile Ile 
1               5                   10                  15      
Met Thr Ile Lys Gly Ala Val 
            20              

<210> 324
<211> 23
<212> PRT
<213> Artificial Sequence


<220> 
<223> C-terminal degron targeted by the CRL4A complex

<400> 324
Phe Asp Arg Glu Ala Lys Glu Lys Lys Leu Ala Trp Pro Ile Asn Ser 
1               5                   10                  15      
Asn Pro Pro Asn Thr Phe Val 
            20              

<210> 325
<211> 23
<212> PRT
<213> Artificial Sequence


<220> 
<223> C-terminal degron targeted by the CRL4A complex

<400> 325
Val Gly Cys Ala Lys Cys Ala Gln Gly Cys Val Cys Lys Gly Ser Ser 
1               5                   10                  15      
Glu Lys Cys Arg Cys Cys Ala 
            20              

<210> 326
<211> 23
<212> PRT
<213> Artificial Sequence


<220> 
<223> C-terminal degron targeted by the CRL4A complex

<400> 326
Val Arg Gly Leu Thr Thr Leu Thr Pro Val Ser Glu Ser Ser Lys Val 
1               5                   10                  15      
Val Val Val Glu Ser Val Met 
            20              

<210> 327
<211> 23
<212> PRT
<213> Artificial Sequence


<220> 
<223> C-terminal degron targeted by the CRL4A complex

<400> 327
Asp Ala Lys Asn Leu Leu Asp Val Ile Asp Gln Ala Arg Leu Lys Met 
1               5                   10                  15      
Leu Gly Gln Thr Arg Pro His 
            20              

<210> 328
<211> 23
<212> PRT
<213> Artificial Sequence


<220> 
<223> C-terminal degron targeted by the CRL4A complex

<400> 328
Glu Lys Phe Asp Lys Val Leu Thr Ala Leu Ser His Lys Leu Glu Pro 
1               5                   10                  15      
Ala Val Arg Ser Ser Glu Leu 
            20              

<210> 329
<211> 23
<212> PRT
<213> Artificial Sequence


<220> 
<223> C-terminal degron targeted by the CRL4A complex

<400> 329
His Pro Asp Ala Gln His Lys Pro Gly Thr Ile Leu Thr Lys Lys Arg 
1               5                   10                  15      
Arg Glu Glu Thr Ile Phe Ala 
            20              

<210> 330
<211> 23
<212> PRT
<213> Artificial Sequence


<220> 
<223> C-terminal degron targeted by the CRL4A complex

<400> 330
Ile Trp Glu Asp Glu Thr Val Leu Pro Met Tyr Glu Gly Arg Ile Leu 
1               5                   10                  15      
Gly Lys Val Glu Arg Ile Asp 
            20              

<210> 331
<211> 23
<212> PRT
<213> Artificial Sequence


<220> 
<223> C-terminal degron targeted by the CRL4A complex

<400> 331
Arg Gln Glu Lys Ile Ser Ala Ala Ala Ser Asp Ser Gly Val Glu Ser 
1               5                   10                  15      
Phe Asp Glu Gly Ser Ser His 
            20              

<210> 332
<211> 23
<212> PRT
<213> Artificial Sequence


<220> 
<223> C-terminal degron targeted by the CRL4A complex

<400> 332
Lys Gly Gln Gly Glu Gln Gly Ser Thr Gly Gly Thr Asn Ile Ser Ser 
1               5                   10                  15      
Thr Ser Glu Pro Lys Glu Glu 
            20              

<210> 333
<211> 23
<212> PRT
<213> Artificial Sequence


<220> 
<223> C-terminal degron targeted by the CRL4A complex

<400> 333
Tyr Thr Ala Leu Asp Lys Trp Thr Asn Gln Leu Asn Ser Leu Asn Gln 
1               5                   10                  15      
Ala Val Val Ser Lys Leu Ala 
            20              

<210> 334
<211> 23
<212> PRT
<213> Artificial Sequence


<220> 
<223> C-terminal degron targeted by the CRL4A complex

<400> 334
Gln Asn Pro Glu Leu Phe Arg Lys Asn Ala Glu Glu Phe Thr Leu Arg 
1               5                   10                  15      
Phe Gly Val Asp Arg Pro Ser 
            20              

<210> 335
<211> 23
<212> PRT
<213> Artificial Sequence


<220> 
<223> C-terminal degron targeted by the CRL4A complex

<400> 335
Asp Pro Leu Val Lys Gly Ile Pro Glu Asp Lys Asn Pro Phe Lys Glu 
1               5                   10                  15      
Lys Gly Ser Cys Val Ile Ser 
            20              

<210> 336
<211> 23
<212> PRT
<213> Artificial Sequence


<220> 
<223> C-terminal degron targeted by the CRL4A complex

<400> 336
Gln Arg Ile Leu Arg Val Asn Leu Ser Pro Val Ile Arg Leu Gln Pro 
1               5                   10                  15      
Leu Leu Pro Tyr Ser Ala Val 
            20              

<210> 337
<211> 23
<212> PRT
<213> Artificial Sequence


<220> 
<223> C-terminal degron targeted by the CRL4A complex

<400> 337
Ser Ile Ala Asn Leu Arg Leu Lys Ala Lys Glu Tyr Ser Leu Gln Arg 
1               5                   10                  15      
Asn Gln Val Pro Thr Val Asn 
            20              

<210> 338
<211> 23
<212> PRT
<213> Artificial Sequence


<220> 
<223> C-terminal degron targeted by the CRL4A complex

<400> 338
Phe Gly Val Ala Asn Thr Ala Gly Ala Leu Ala Gly Val Val Gly Val 
1               5                   10                  15      
Cys Leu Gly Gly Tyr Leu Met 
            20              

<210> 339
<211> 23
<212> PRT
<213> Artificial Sequence


<220> 
<223> C-terminal degron targeted by the CRL4A complex

<400> 339
Pro Ala Pro His Thr Pro Arg Ala Leu Gly Ile Leu Arg Arg Gln Pro 
1               5                   10                  15      
Leu Pro Ala Ser Met Pro Ala 
            20              

<210> 340
<211> 23
<212> PRT
<213> Artificial Sequence


<220> 
<223> C-terminal degron targeted by the CRL4A complex

<400> 340
Ser Glu Leu Phe Arg Ser Arg Leu Asp Ser Tyr Val Arg Ser Leu Pro 
1               5                   10                  15      
Phe Phe Ser Ala Arg Ala Gly 
            20              

<210> 341
<211> 23
<212> PRT
<213> Artificial Sequence


<220> 
<223> C-terminal degron targeted by the CRL4A complex

<400> 341
Val Arg Ala Glu Ile Met Arg Ser Phe Ser Phe Ser Thr Asn Leu Lys 
1               5                   10                  15      
Lys Gly Leu Arg Arg Lys Asp 
            20              

<210> 342
<211> 23
<212> PRT
<213> Artificial Sequence


<220> 
<223> C-terminal degron targeted by the CRL4A complex

<400> 342
Thr Thr Asp Asp Thr Thr Ala Met Ala Ser Ala Ser Ser Ser Ala Thr 
1               5                   10                  15      
Gly Ser Phe Ser Tyr Pro Glu 
            20              

<210> 343
<211> 23
<212> PRT
<213> Artificial Sequence


<220> 
<223> C-terminal degron targeted by the CRL4A complex

<400> 343
Arg Lys Pro Tyr Ile Val Lys Asn Val Thr Asp Leu Leu Asn Val Pro 
1               5                   10                  15      
Pro Leu Leu Ile Ser Ile Arg 
            20              

<210> 344
<211> 23
<212> PRT
<213> Artificial Sequence


<220> 
<223> C-terminal degron targeted by the CRL4A complex

<400> 344
Gly Arg Tyr His Glu Leu Tyr Gln Gln Ser Asp Thr Trp Ser Leu Ser 
1               5                   10                  15      
Lys Thr Ser Leu Val Asn Glu 
            20              

<210> 345
<211> 23
<212> PRT
<213> Artificial Sequence


<220> 
<223> C-terminal degron targeted by the CRL4A complex

<400> 345
Trp Pro Ala Val Leu Arg Lys Leu Arg Phe Thr Ala Val Pro Lys Asn 
1               5                   10                  15      
His Gln Ala Val Arg Asn Pro 
            20              

<210> 346
<211> 23
<212> PRT
<213> Artificial Sequence


<220> 
<223> C-terminal degron targeted by the CRL4A complex

<400> 346
Val Ala Arg Thr Leu Ser Pro Gly Gln Ala Leu Tyr Asn Ile Ile Ser 
1               5                   10                  15      
Thr Trp Pro His Phe Lys His 
            20              

<210> 347
<211> 23
<212> PRT
<213> Artificial Sequence


<220> 
<223> C-terminal degron targeted by the CRL4A complex

<400> 347
Asn Arg Gln Phe Arg Gln Ala Tyr Gly Ser Ile Leu Lys Arg Gly Pro 
1               5                   10                  15      
Arg Ser Phe His Arg Leu His 
            20              

<210> 348
<211> 23
<212> PRT
<213> Artificial Sequence


<220> 
<223> C-terminal degron targeted by the CRL4A complex

<400> 348
Val Tyr Trp Val Pro Thr Gln Tyr Val Asp Ala Ile Lys Asp Thr Val 
1               5                   10                  15      
Leu Gly Lys Trp Gln Tyr Phe 
            20              

<210> 349
<211> 23
<212> PRT
<213> Artificial Sequence


<220> 
<223> C-terminal degron targeted by the CRL4A complex

<400> 349
Asp Ile Pro Val Lys Thr Leu Asn Met Lys Thr Val Tyr Val Ser Val 
1               5                   10                  15      
Leu Pro Thr Thr Ala Asp Phe 
            20              

<210> 350
<211> 23
<212> PRT
<213> Artificial Sequence


<220> 
<223> C-terminal degron targeted by the CRL4A complex

<400> 350
Thr Gln Val Gly Ile Glu Trp Asn Leu Ser Pro Val Gly Arg Val Thr 
1               5                   10                  15      
Pro Lys Glu Trp Arg Asn Gln 
            20              

<210> 351
<211> 23
<212> PRT
<213> Artificial Sequence


<220> 
<223> C-terminal degron targeted by the CRL4A complex

<400> 351
Tyr Ile Val Met Thr Val Gln Glu Leu Leu Pro Ser Ser Phe Gly Pro 
1               5                   10                  15      
Glu Asp Leu Gln Lys Thr Gln 
            20              

<210> 352
<211> 23
<212> PRT
<213> Artificial Sequence


<220> 
<223> C-terminal degron targeted by the CRL4A complex

<400> 352
Leu Ile Gln Phe Gly Val Gly Glu Arg Pro Gln Ala Gln Glu Asn Val 
1               5                   10                  15      
Asp Tyr Val Ile Leu Lys His 
            20              

<210> 353
<211> 23
<212> PRT
<213> Artificial Sequence


<220> 
<223> C-terminal degron targeted by the CRL4A complex

<400> 353
Leu Asp Lys Asp Gly Thr Gly Gln Ile Gln Val Asn Ile Gln Glu Trp 
1               5                   10                  15      
Leu Gln Leu Thr Met Tyr Ser 
            20              

<210> 354
<211> 23
<212> PRT
<213> Artificial Sequence


<220> 
<223> C-terminal degron targeted by the CRL4A complex

<400> 354
Gln Gln Lys Glu Ala Thr Thr Glu Gln Gln Leu Lys Glu Leu Phe Glu 
1               5                   10                  15      
Lys Gln Lys Phe Lys Ser Gln 
            20              

<210> 355
<211> 23
<212> PRT
<213> Artificial Sequence


<220> 
<223> C-terminal degron targeted by the CRL4A complex

<400> 355
Phe Asp Asn Ser Asp Asn Val Val Leu Arg Gln Tyr Glu Asp Met Val 
1               5                   10                  15      
Val Asp Glu Cys Gly Cys Arg 
            20              

<210> 356
<211> 23
<212> PRT
<213> Artificial Sequence


<220> 
<223> C-terminal degron targeted by the CRL4A complex

<400> 356
Met Ala Phe Pro Ser Ser Gln Ser Leu Tyr Arg Thr Ser Gly Ala Phe 
1               5                   10                  15      
Val Tyr Asp Cys Ser Lys Phe 
            20              

<210> 357
<211> 23
<212> PRT
<213> Artificial Sequence


<220> 
<223> C-terminal degron targeted by the CRL4A complex

<400> 357
Ser Lys Tyr Gly Arg Asp Trp Glu Arg Tyr Thr Ala Ala Val Pro Tyr 
1               5                   10                  15      
Arg Leu Leu Pro Gly Ile Phe 
            20              

<210> 358
<211> 23
<212> PRT
<213> Artificial Sequence


<220> 
<223> C-terminal degron targeted by the CRL4A complex

<400> 358
Gly Thr Cys Lys Thr Ser Val Ala Thr Gln Cys Asp Pro Glu Glu Ile 
1               5                   10                  15      
Ile Val Leu Ser Asp Ser Asp 
            20              

<210> 359
<211> 23
<212> PRT
<213> Artificial Sequence


<220> 
<223> C-terminal degron targeted by the CRL4A complex

<400> 359
Lys Cys Ser His Cys Asp Arg Cys Phe Ser Arg Ser Asp His Leu Ala 
1               5                   10                  15      
Leu His Met Lys Arg His Leu 
            20              

<210> 360
<211> 23
<212> PRT
<213> Artificial Sequence


<220> 
<223> C-terminal degron targeted by the CRL4A complex

<400> 360
Gln Ser Ser Met Gly Tyr Ser Ala Thr Ser Gln Gln Pro Pro Gln Tyr 
1               5                   10                  15      
Ser His Gln Thr His Arg Tyr 
            20              

<210> 361
<211> 23
<212> PRT
<213> Artificial Sequence


<220> 
<223> C-terminal degron targeted by the CRL4A complex

<400> 361
Gly His Ser His His Ser His His Gly His Pro Ser His Gln Ser His 
1               5                   10                  15      
Ser Leu Pro Asn Arg Arg His 
            20              

<210> 362
<211> 23
<212> PRT
<213> Artificial Sequence


<220> 
<223> C-terminal degron targeted by the CRL4A complex

<400> 362
Pro Ser Val Tyr Phe Ile Lys Phe Asp Asp Asp Phe His Ile Tyr Val 
1               5                   10                  15      
Tyr Asp Leu Val Lys Lys Ser 
            20              

<210> 363
<211> 23
<212> PRT
<213> Artificial Sequence


<220> 
<223> C-terminal degron targeted by the CRL4A complex

<400> 363
Asp Leu Leu Ile Gln Glu Leu Leu Ala Cys Leu Leu Asp Gln Thr Asn 
1               5                   10                  15      
Leu Cys Arg Leu Arg Ser Arg 
            20              

<210> 364
<211> 23
<212> PRT
<213> Artificial Sequence


<220> 
<223> C-terminal degron targeted by the CRL4A complex

<400> 364
Lys Phe Leu Leu Lys Leu Val Lys Glu Gly Val Val Lys Asp Leu Ser 
1               5                   10                  15      
Gly Gly Ile Asp Arg Glu Phe 
            20              

<210> 365
<211> 23
<212> PRT
<213> Artificial Sequence


<220> 
<223> C-terminal degron targeted by the CRL4A complex

<400> 365
Thr Val Thr Ala Met Asp Val Val Tyr Ala Leu Lys Arg Gln Gly Arg 
1               5                   10                  15      
Thr Leu Tyr Gly Phe Gly Gly 
            20              

<210> 366
<211> 23
<212> PRT
<213> Artificial Sequence


<220> 
<223> C-terminal degron targeted by the CRL4A complex

<400> 366
Asp Cys Gly Arg Arg Tyr Lys Arg Arg Leu Asn Leu Asp Ile Leu Leu 
1               5                   10                  15      
Ser Leu Phe Leu Asn Asp Thr 
            20              

<210> 367
<211> 23
<212> PRT
<213> Artificial Sequence


<220> 
<223> C-terminal degron targeted by the CRL4A complex

<400> 367
Pro Lys Thr Ile Val Phe Ile Ile His Ser Phe Leu Ser Ala Lys Val 
1               5                   10                  15      
Thr Arg Leu Gly Leu Leu Ala 
            20              

<210> 368
<211> 23
<212> PRT
<213> Artificial Sequence


<220> 
<223> C-terminal degron targeted by the CRL4A complex

<400> 368
Glu Lys Met His Glu Gly Asp Glu Gly Pro Gly His His His Lys Pro 
1               5                   10                  15      
Gly Leu Gly Glu Gly Thr Pro 
            20              

<210> 369
<211> 23
<212> PRT
<213> Artificial Sequence


<220> 
<223> C-terminal degron targeted by the CRL4A complex

<400> 369
Lys Thr Met Val Pro Asn Gln Val Ser Leu Arg Ala Arg Arg Asp Cys 
1               5                   10                  15      
Gly Val Ile Ala Arg Val Pro 
            20              

<210> 370
<211> 23
<212> PRT
<213> Artificial Sequence


<220> 
<223> C-terminal degron targeted by the CRL4A complex

<400> 370
Met Glu Met Met Ser Gln Lys Ile Gln Gln Leu Thr Ala Leu Gly Ala 
1               5                   10                  15      
Ala Gln Ala Thr Ala Lys Ala 
            20              

<210> 371
<211> 23
<212> PRT
<213> Artificial Sequence


<220> 
<223> C-terminal degron targeted by the CRL4A complex

<400> 371
Thr Leu Lys Asn Phe Gly Leu Met Met His Thr Val Tyr Asp Ser Ile 
1               5                   10                  15      
Trp Cys Asn Met Lys Ser Asn 
            20              

<210> 372
<211> 23
<212> PRT
<213> Artificial Sequence


<220> 
<223> C-terminal degron targeted by the CRL4A complex

<400> 372
Lys Lys Lys Leu Gly Cys Gln Leu Leu Gly Lys Tyr Lys Gln Ile Ile 
1               5                   10                  15      
Ala Val Leu Ala Gln Ala Phe 
            20              

<210> 373
<211> 23
<212> PRT
<213> Artificial Sequence


<220> 
<223> C-terminal degron targeted by the CRL4A complex

<400> 373
Val Gln Thr Gly Ser Thr Ala Gln Ile Leu Gln Pro Asp Ser Gly Thr 
1               5                   10                  15      
Thr Leu Ser Ser Pro Pro Val 
            20              

<210> 374
<211> 23
<212> PRT
<213> Artificial Sequence


<220> 
<223> C-terminal degron targeted by the CRL4A complex

<400> 374
Arg Arg Leu Asp Lys Lys Leu Ser Glu Leu Ser Asn Gln Arg Thr Ser 
1               5                   10                  15      
Arg Arg Lys Glu Arg Gly Thr 
            20              

<210> 375
<211> 23
<212> PRT
<213> Artificial Sequence


<220> 
<223> C-terminal degron targeted by the CRL4A complex

<400> 375
Val Arg Ala Glu Ile Met Arg Ser Phe Ser Phe Ser Thr Asn Leu Gln 
1               5                   10                  15      
Lys Gly Leu Arg Arg Lys Asp 
            20              

<210> 376
<211> 23
<212> PRT
<213> Artificial Sequence


<220> 
<223> C-terminal degron targeted by the CRL4A complex

<400> 376
Met Asn Pro Ile Val Tyr Ser Val Lys Thr Lys Gln Ile Arg Asp Arg 
1               5                   10                  15      
Val Thr His Ala Phe Cys Tyr 
            20              

<210> 377
<211> 23
<212> PRT
<213> Artificial Sequence


<220> 
<223> C-terminal degron targeted by the CRL4A complex

<400> 377
Ser Ile Tyr Ser Leu Arg Asn Lys Asp Asp Lys Leu Ala Leu Gly Lys 
1               5                   10                  15      
Thr Leu Lys Arg Val Leu Phe 
            20              

<210> 378
<211> 23
<212> PRT
<213> Artificial Sequence


<220> 
<223> C-terminal degron targeted by the CRL4A complex

<400> 378
Leu Arg Lys Leu Phe Asp Gln His Lys Thr Lys Phe Gly Ile Ser Glu 
1               5                   10                  15      
Thr Gln Glu Leu Glu Ile Ile 
            20              

<210> 379
<211> 23
<212> PRT
<213> Artificial Sequence


<220> 
<223> C-terminal degron targeted by the CRL4A complex

<400> 379
Asn Arg Thr Arg Gln Ala Val Ile Thr Lys Glu Leu Ile Glu Ile Ile 
1               5                   10                  15      
Ser Gly Ala Ala Ala Leu Asp 
            20              

<210> 380
<211> 23
<212> PRT
<213> Artificial Sequence


<220> 
<223> C-terminal degron targeted by the CRL4A complex

<400> 380
Tyr Ser Leu Arg Asn Lys Asp Met Leu Lys Ala Leu Arg Lys Leu Ile 
1               5                   10                  15      
Ser Arg Ile Pro Ser Phe His 
            20              

<210> 381
<211> 23
<212> PRT
<213> Artificial Sequence


<220> 
<223> C-terminal degron targeted by the CRL4A complex

<400> 381
Gly Tyr Val Pro Ser Gly Phe Leu Ala Arg Ala Arg Ser Pro Val Leu 
1               5                   10                  15      
Trp Gly Trp Ser Leu Pro Ser 
            20              

<210> 382
<211> 23
<212> PRT
<213> Artificial Sequence


<220> 
<223> C-terminal degron targeted by the CRL4A complex

<400> 382
Pro Val Ile Tyr Thr Val Phe Asn Ala Glu Phe Arg Asn Val Phe Arg 
1               5                   10                  15      
Lys Ala Leu Arg Ala Cys Cys 
            20              

<210> 383
<211> 23
<212> PRT
<213> Artificial Sequence


<220> 
<223> C-terminal degron targeted by the CRL4A complex

<400> 383
Thr Val Asp Pro Pro Tyr Pro Arg Ser Ile Ala Gln Tyr Trp Leu Gly 
1               5                   10                  15      
Cys Pro Ala Pro Gly His Leu 
            20              

<210> 384
<211> 23
<212> PRT
<213> Artificial Sequence


<220> 
<223> C-terminal degron targeted by the CRL4A complex

<400> 384
Ser Pro Ala Ala Lys Thr Gly Lys Arg Lys Arg Ser Gln Met Leu Phe 
1               5                   10                  15      
Arg Gly Arg Arg Ala Ser Gln 
            20              

<210> 385
<211> 23
<212> PRT
<213> Artificial Sequence


<220> 
<223> C-terminal degron targeted by the CRL4A complex

<400> 385
Pro Trp Asn Cys Pro His Gly Arg Pro Thr Met Arg His Ile Ala Asn 
1               5                   10                  15      
Leu Gly Val Ile Ser Gln Asn 
            20              

<210> 386
<211> 23
<212> PRT
<213> Artificial Sequence


<220> 
<223> C-terminal degron targeted by the CRL4A complex

<400> 386
Phe Phe Arg Pro Ile Ile Gly Thr Val Ser Met Asp Asp Met Met Leu 
1               5                   10                  15      
Glu Met Leu Cys Thr Lys Ile 
            20              

<210> 387
<211> 23
<212> PRT
<213> Artificial Sequence


<220> 
<223> C-terminal degron targeted by the CRL4A complex

<400> 387
Lys Leu Gln Ser Thr Thr Val Met Asn Pro Tyr Met Lys Leu Ala Pro 
1               5                   10                  15      
Gly Glu Leu Thr Ile Ile Leu 
            20              

<210> 388
<211> 23
<212> PRT
<213> Artificial Sequence


<220> 
<223> C-terminal degron targeted by the CRL4A complex

<400> 388
Leu Gln Pro Ser Val Ser Glu Gln Glu Leu Leu Arg Tyr Lys Arg Ile 
1               5                   10                  15      
Gln Arg Lys Phe Ala Ala Cys 
            20              

<210> 389
<211> 23
<212> PRT
<213> Artificial Sequence


<220> 
<223> C-terminal degron targeted by the CRL4A complex

<400> 389
Tyr Cys Pro Phe Ser Cys Glu Thr Gln Ala Trp Ser Ile Ala Thr Ile 
1               5                   10                  15      
Leu Glu Thr Leu Tyr Asp Leu 
            20              

<210> 390
<211> 23
<212> PRT
<213> Artificial Sequence


<220> 
<223> C-terminal degron targeted by the CRL4B complex

<400> 390
Ser Val Asn Ile Gln Glu Leu Leu Leu Gly Lys Glu Phe Leu Asn Ile 
1               5                   10                  15      
Thr Thr Glu Glu Asn Leu Trp 
            20              

<210> 391
<211> 23
<212> PRT
<213> Artificial Sequence


<220> 
<223> C-terminal degron targeted by the CRL4B complex

<400> 391
Gly Asp Ile Cys Ala Cys Ala Asn Ile Arg Arg Val Pro Phe Thr Phe 
1               5                   10                  15      
Lys Trp Trp Lys Met Val Pro 
            20              

<210> 392
<211> 23
<212> PRT
<213> Artificial Sequence


<220> 
<223> C-terminal degron targeted by the CRL4B complex

<400> 392
Ser Pro Ser Ala Leu Val Ser Tyr Ile Glu Glu Pro Tyr Met Asp Ile 
1               5                   10                  15      
Asp Arg Asp Phe Thr Glu Glu 
            20              

<210> 393
<211> 23
<212> PRT
<213> Artificial Sequence


<220> 
<223> C-terminal degron targeted by the CRL4B complex

<400> 393
Ala Ser Cys Cys Arg Pro Ala Ser Cys Val Ser Leu Leu Cys Arg Pro 
1               5                   10                  15      
Ala Cys Ser Pro Leu Ala Cys 
            20              

<210> 394
<211> 23
<212> PRT
<213> Artificial Sequence


<220> 
<223> C-terminal degron targeted by the CRL4B complex

<400> 394
Thr Gly Lys Ile Gln Arg Thr Lys Leu Arg Asp Lys Glu Trp Lys Met 
1               5                   10                  15      
Ser Gly Lys Ala Arg Ala Gln 
            20              

<210> 395
<211> 23
<212> PRT
<213> Artificial Sequence


<220> 
<223> C-terminal degron targeted by the CRL4B complex

<400> 395
Leu Tyr Ser Trp Glu Asp Gly His Leu Met Leu Tyr Pro Val Gln Phe 
1               5                   10                  15      
Leu Ser Thr Thr Leu Asn Gln 
            20              

<210> 396
<211> 23
<212> PRT
<213> Artificial Sequence


<220> 
<223> C-terminal degron targeted by the CRL4B complex

<400> 396
Cys Cys Ala Leu Thr Gly Glu Gly Leu Cys Gln Gly Leu Glu Trp Met 
1               5                   10                  15      
Thr Ser Arg Ile Gly Val Arg 
            20              

<210> 397
<211> 23
<212> PRT
<213> Artificial Sequence


<220> 
<223> C-terminal degron targeted by the CRL4B complex

<400> 397
His Arg Tyr Leu Thr Tyr Arg Tyr Phe Pro Arg Arg Arg Leu Gln Arg 
1               5                   10                  15      
Gly Ser Ser Ser Glu Glu Ser 
            20              

<210> 398
<211> 23
<212> PRT
<213> Artificial Sequence


<220> 
<223> C-terminal degron targeted by the CRL4B complex

<400> 398
Asp Thr Leu Pro Arg Leu Cys Ala Leu Tyr Ala Gly Leu Ser His Leu 
1               5                   10                  15      
Gln Gln Leu Thr Lys Ala Ser 
            20              

<210> 399
<211> 23
<212> PRT
<213> Artificial Sequence


<220> 
<223> C-terminal degron targeted by the CRL4B complex

<400> 399
Leu Val Ala Ser His Leu Gln Ser Phe Leu Glu Val Ser Tyr Arg Val 
1               5                   10                  15      
Leu Arg His Leu Ala Gln Pro 
            20              

<210> 400
<211> 23
<212> PRT
<213> Artificial Sequence


<220> 
<223> C-terminal degron targeted by the CRL4B complex

<400> 400
Phe Leu Phe Thr Tyr Leu Pro Pro Phe Leu Asn Leu Leu Thr Val Gly 
1               5                   10                  15      
Phe Val Ser Tyr Phe Leu Val 
            20              

<210> 401
<211> 23
<212> PRT
<213> Artificial Sequence


<220> 
<223> C-terminal degron targeted by the CRL4B complex

<400> 401
Ala Glu Ile Arg Ala Gln Val Lys Ser Gly Ser Leu Pro Val Gly Thr 
1               5                   10                  15      
Phe Val Gln Thr His Lys Lys 
            20              

<210> 402
<211> 23
<212> PRT
<213> Artificial Sequence


<220> 
<223> C-terminal degron targeted by the CRL4B complex

<400> 402
Thr Val Glu Val Gln Ile Gln Leu Asn Gln Cys Arg Ser Ala Glu Glu 
1               5                   10                  15      
Ala Leu Arg Met Phe Ala Val 
            20              

<210> 403
<211> 23
<212> PRT
<213> Artificial Sequence


<220> 
<223> C-terminal degron targeted by the CRL4B complex

<400> 403
His Met Gly Tyr Ser Met Ala Ile Leu Asn Gly Ile Val Ala Ala Leu 
1               5                   10                  15      
Thr Val Ala Trp Cys Leu Met 
            20              

<210> 404
<211> 23
<212> PRT
<213> Artificial Sequence


<220> 
<223> C-terminal degron targeted by the CRL4B complex

<400> 404
Pro Trp Glu Leu Thr Glu Leu Trp Lys Leu Lys Glu Arg Cys Gly Asp 
1               5                   10                  15      
Pro Cys Arg Cys Gln Ala Arg 
            20              

<210> 405
<211> 23
<212> PRT
<213> Artificial Sequence


<220> 
<223> C-terminal degron targeted by the CRL4B complex

<400> 405
Cys Gly Lys Thr Phe Gln Arg Ser Ser Thr Leu Leu His His Gln Ser 
1               5                   10                  15      
Ser His Arg Arg Lys Ala Leu 
            20              

<210> 406
<211> 23
<212> PRT
<213> Artificial Sequence


<220> 
<223> C-terminal degron targeted by the CRL4B complex

<400> 406
Trp Thr Trp Lys Asn Cys Ser Gly Glu Met Pro Phe Ile Ser Ser Phe 
1               5                   10                  15      
Ser Val Ser Asn Ser Ser Ser 
            20              

<210> 407
<211> 23
<212> PRT
<213> Artificial Sequence


<220> 
<223> C-terminal degron targeted by the CRL4B complex

<400> 407
Glu Cys Gly Lys Ala Phe Ile Arg Ser Ser Tyr Cys Arg Lys His Glu 
1               5                   10                  15      
Arg Thr His Thr Ile Asn Ile 
            20              

<210> 408
<211> 23
<212> PRT
<213> Artificial Sequence


<220> 
<223> C-terminal degron targeted by the CRL4B complex

<400> 408
Leu Thr Ile Arg Val Ala Ser Thr Asn Pro Ala Val Gln Ala Phe Asp 
1               5                   10                  15      
Ile Trp Ser Trp Arg Pro Ala 
            20              

<210> 409
<211> 23
<212> PRT
<213> Artificial Sequence


<220> 
<223> C-terminal degron targeted by the CRL4B complex

<400> 409
Gly Pro Gln His Gln Ala Gly Ser Asp Ser Leu Leu Thr Gly Met Ala 
1               5                   10                  15      
Phe Phe Lys Met Arg Glu Val 
            20              

<210> 410
<211> 23
<212> PRT
<213> Artificial Sequence


<220> 
<223> C-terminal degron targeted by the CRL4B complex

<400> 410
Ile Ile Pro Ile Ser Ile Val Ala Tyr Lys Gln Val Pro Leu Ser Pro 
1               5                   10                  15      
Tyr Gly Asp Ile Ile Glu Lys 
            20              

<210> 411
<211> 23
<212> PRT
<213> Artificial Sequence


<220> 
<223> C-terminal degron targeted by the CRL4B complex

<400> 411
Gly Thr His Phe Trp Ala Gln Pro Gln Asp Val Arg Trp Glu Ser Leu 
1               5                   10                  15      
Ser Gly Ser Thr Asp Asp Gly 
            20              

<210> 412
<211> 23
<212> PRT
<213> Artificial Sequence


<220> 
<223> C-terminal degron targeted by the CRL4B complex

<400> 412
Glu Gly Leu Ser Ile Gly Ile Val Asp Asp Glu Asp Phe Val Asn Ile 
1               5                   10                  15      
Leu Arg Thr Pro Trp Gly Ile 
            20              

<210> 413
<211> 23
<212> PRT
<213> Artificial Sequence


<220> 
<223> C-terminal degron targeted by the CRL4B complex

<400> 413
His Ile Met Lys Trp Leu Glu Gly Ser Ser His Cys Pro Ala Gly Cys 
1               5                   10                  15      
Gly His Leu Cys Glu Tyr Ser 
            20              

<210> 414
<211> 23
<212> PRT
<213> Artificial Sequence


<220> 
<223> C-terminal degron targeted by the CRL4B complex

<400> 414
Ala Gly Arg Trp Pro Ala Pro Ile Pro Leu Leu Leu Leu Pro Leu Leu 
1               5                   10                  15      
Val Gly Gly Val Ala Ser Arg 
            20              

<210> 415
<211> 23
<212> PRT
<213> Artificial Sequence


<220> 
<223> C-terminal degron targeted by the CRL4B complex

<400> 415
Cys Pro Lys Cys Gly Glu Val Leu Pro Asp Ile Asp Thr Leu Gln Ile 
1               5                   10                  15      
His Val Met Asp Cys Ile Ile 
            20              

<210> 416
<211> 23
<212> PRT
<213> Artificial Sequence


<220> 
<223> C-terminal degron targeted by the CRL4B complex

<400> 416
Arg Arg Gly Pro Gly Phe Pro Arg Leu Gly Pro Gly Trp Ala Gly Ala 
1               5                   10                  15      
His Arg Arg Leu Ala Glu Gly 
            20              

<210> 417
<211> 23
<212> PRT
<213> Artificial Sequence


<220> 
<223> C-terminal degron targeted by the CRL4B complex

<400> 417
Gly Met Glu Arg Arg Asp Leu Trp Cys Thr Ala Cys Arg Trp Lys Lys 
1               5                   10                  15      
Ala Cys Gln Arg Phe Leu Asp 
            20              

<210> 418
<211> 23
<212> PRT
<213> Artificial Sequence


<220> 
<223> C-terminal degron targeted by the CRL4B complex

<400> 418
Leu Tyr Lys Leu Tyr Glu Ala Asp Phe Val Leu Phe Gly Tyr Pro Lys 
1               5                   10                  15      
Pro Glu Asn Leu Leu Arg Asp 
            20              

<210> 419
<211> 23
<212> PRT
<213> Artificial Sequence


<220> 
<223> C-terminal degron targeted by the CRL4B complex

<400> 419
Gly Ile Leu Asn Gly Leu Tyr His Tyr Ala Val Phe Glu Glu Thr Leu 
1               5                   10                  15      
Glu Lys Thr Ile His Glu Glu 
            20              

<210> 420
<211> 23
<212> PRT
<213> Artificial Sequence


<220> 
<223> C-terminal degron targeted by the CRL4B complex

<400> 420
His Arg Trp Asn Gly His Thr Asp Met Ile Asp Gln Asp Gly Leu Tyr 
1               5                   10                  15      
Glu Lys Leu Lys Thr Glu Leu 
            20              

<210> 421
<211> 23
<212> PRT
<213> Artificial Sequence


<220> 
<223> C-terminal degron targeted by the CRL4B complex

<400> 421
Cys Ala Met Leu Phe Arg Gln Leu His Gln Glu Leu Pro Ser His Gly 
1               5                   10                  15      
Val Pro Leu Ile Asn His Leu 
            20              

<210> 422
<211> 23
<212> PRT
<213> Artificial Sequence


<220> 
<223> C-terminal degron targeted by the CRL4B complex

<400> 422
Asn Gln Gly Gly Gly Gly Leu Gly Leu Glu Thr Leu Pro Ala Leu Glu 
1               5                   10                  15      
Glu Gly Leu Thr Arg Glu Glu 
            20              

<210> 423
<211> 23
<212> PRT
<213> Artificial Sequence


<220> 
<223> C-terminal degron targeted by the CRL4B complex

<400> 423
Asp Thr Val Leu Leu Val Leu Lys Glu Ile Tyr Gln Thr Gln Gly Ile 
1               5                   10                  15      
Phe Leu Asp Gln Pro Leu Gln 
            20              

<210> 424
<211> 23
<212> PRT
<213> Artificial Sequence


<220> 
<223> C-terminal degron targeted by the CRL4B complex

<400> 424
Arg Glu Phe His Lys Pro Leu Val Lys Glu Gly Gly Asp Arg Pro Arg 
1               5                   10                  15      
His Val Pro Phe Arg Trp Ser 
            20              

<210> 425
<211> 23
<212> PRT
<213> Artificial Sequence


<220> 
<223> C-terminal degron targeted by the CRL4B complex

<400> 425
Ser His Cys His Gly Ser Phe Ser Leu Ile Phe Leu Ser Leu Trp Ala 
1               5                   10                  15      
Val Ile Phe Val Leu Tyr Gln 
            20              

<210> 426
<211> 23
<212> PRT
<213> Artificial Sequence


<220> 
<223> C-terminal degron targeted by the CRL4B complex

<400> 426
Lys Lys Ala Gly Ala Ser Cys Pro Ile Cys Lys Lys Glu Ile Gln Leu 
1               5                   10                  15      
Val Ile Lys Val Phe Ile Ala 
            20              

<210> 427
<211> 23
<212> PRT
<213> Artificial Sequence


<220> 
<223> C-terminal degron targeted by the CRL4B complex

<400> 427
Leu Gln Ala Leu Thr Arg Lys Leu Glu Ala Val Ser Lys Arg Leu Ala 
1               5                   10                  15      
Ile Leu Glu Asn Thr Val Val 
            20              

<210> 428
<211> 23
<212> PRT
<213> Artificial Sequence


<220> 
<223> C-terminal degron targeted by the CRL4B complex

<400> 428
Ser Ser Ala Arg Ser Thr Gln Gly Thr Thr Gly Ile Arg Glu Asp Pro 
1               5                   10                  15      
Asp Val Cys Leu Lys Ala Pro 
            20              

<210> 429
<211> 23
<212> PRT
<213> Artificial Sequence


<220> 
<223> C-terminal degron targeted by the CRL4B complex

<400> 429
Cys Lys Glu Glu Leu Leu Leu Gly Arg Thr Ser Pro Ser Lys Asn Tyr 
1               5                   10                  15      
Asn Met Met Thr Val Ser Gly 
            20              

<210> 430
<211> 23
<212> PRT
<213> Artificial Sequence


<220> 
<223> C-terminal degron targeted by the CRL4B complex

<400> 430
Arg Asn Trp Arg Val Cys Ala Leu Leu Ser Cys Thr Ser His Lys Asp 
1               5                   10                  15      
Tyr Pro Phe His Glu Glu Phe 
            20              

<210> 431
<211> 23
<212> PRT
<213> Artificial Sequence


<220> 
<223> C-terminal degron targeted by the CRL4B complex

<400> 431
Asn Glu Arg Phe Asp Ala Asp Tyr Ala Glu Lys Met Ala Gly Cys Ser 
1               5                   10                  15      
Leu Ser Phe Arg Ser Glu Leu 
            20              

<210> 432
<211> 23
<212> PRT
<213> Artificial Sequence


<220> 
<223> C-terminal degron targeted by the CRL4B complex

<400> 432
Glu Asn Glu His His Leu Val Ala Gln Arg Asp Ile Arg Gln Phe Gln 
1               5                   10                  15      
Leu Gln His Trp Leu Ala Ile 
            20              

<210> 433
<211> 23
<212> PRT
<213> Artificial Sequence


<220> 
<223> C-terminal degron targeted by the CRL4B complex

<400> 433
Leu Arg Asn Gln Glu Val Lys Leu Ala Leu Lys Arg Met Leu Arg Ser 
1               5                   10                  15      
Pro Arg Thr Pro Ser Glu Val 
            20              

<210> 434
<211> 23
<212> PRT
<213> Artificial Sequence


<220> 
<223> C-terminal degron targeted by the CRL4B complex

<400> 434
Lys Gln Ile Arg Gln Arg Ile Ile Lys Lys Phe Gln Phe Ile Lys Ser 
1               5                   10                  15      
Leu Arg Cys Phe Trp Lys Asp 
            20              

<210> 435
<211> 23
<212> PRT
<213> Artificial Sequence


<220> 
<223> C-terminal degron targeted by the CRL4B complex

<400> 435
Ile Asp Ile Pro Pro Gly Ala Val Leu Glu Asn Lys Ile Val Ser Gly 
1               5                   10                  15      
Asn Leu Arg Ile Leu Asp His 
            20              

<210> 436
<211> 23
<212> PRT
<213> Artificial Sequence


<220> 
<223> C-terminal degron targeted by the CRL4B complex

<400> 436
Leu Gln Leu Val Ala Ser Gly Thr Val Gln Leu Gly Glu Asn Gly Lys 
1               5                   10                  15      
Ile Cys Trp Val Lys Glu Glu 
            20              

<210> 437
<211> 23
<212> PRT
<213> Artificial Sequence


<220> 
<223> C-terminal degron targeted by the CRL4B complex

<400> 437
Val Met Gly Gly Phe Lys Val Glu Asn His Thr Ala Cys His Cys Ser 
1               5                   10                  15      
Thr Cys Tyr Tyr His Lys Ser 
            20              

<210> 438
<211> 23
<212> PRT
<213> Artificial Sequence


<220> 
<223> C-terminal degron targeted by the CRL4B complex

<400> 438
Val Gly Thr Trp Lys Ser Arg Ser Thr Met Glu Lys Tyr Phe Arg Glu 
1               5                   10                  15      
Trp Lys Leu Glu Ala Gly Tyr 
            20              

<210> 439
<211> 23
<212> PRT
<213> Artificial Sequence


<220> 
<223> C-terminal degron targeted by the CRL4B complex

<400> 439
Lys Phe Gly Leu Tyr Leu Pro Leu Phe Lys Pro Ser Val Ser Thr Ser 
1               5                   10                  15      
Lys Ala Ile Gly Gly Gly Pro 
            20              

<210> 440
<211> 23
<212> PRT
<213> Artificial Sequence


<220> 
<223> C-terminal degron targeted by the CRL4B complex

<400> 440
Ala Met Asn Glu Ser Ser Lys Thr Asp Gln Tyr Leu Cys Asp Ala Asp 
1               5                   10                  15      
Arg Leu Gln Glu Arg Glu Leu 
            20              

<210> 441
<211> 23
<212> PRT
<213> Artificial Sequence


<220> 
<223> C-terminal degron targeted by the CRL4B complex

<400> 441
Gln Phe Val Gln Trp Asp Glu Leu Leu Cys Gln Leu Glu Ala Ala Thr 
1               5                   10                  15      
Gln Val Lys Pro Ala Glu Glu 
            20              

<210> 442
<211> 23
<212> PRT
<213> Artificial Sequence


<220> 
<223> C-terminal degron targeted by the CRL4B complex

<400> 442
Gln Thr Leu Cys Gln Tyr Thr Phe Val Tyr Arg Val Leu Ile Gln Phe 
1               5                   10                  15      
Leu Lys Ser Ser Arg Leu Ile 
            20              

<210> 443
<211> 23
<212> PRT
<213> Artificial Sequence


<220> 
<223> C-terminal degron targeted by the CRL4B complex

<400> 443
Ala Asp Phe Glu Ala His Ile Ile Asp Met Leu Ala Lys Ala Ser Lys 
1               5                   10                  15      
Ile Glu Val Tyr Arg Gly Asn 
            20              

<210> 444
<211> 23
<212> PRT
<213> Artificial Sequence


<220> 
<223> C-terminal degron targeted by the CRL4B complex

<400> 444
Glu Lys Ser Lys Gly Ser Lys Arg Ala Lys Ala Asn Thr Gly Arg Lys 
1               5                   10                  15      
Tyr Asn Lys Lys Val Glu Glu 
            20              

<210> 445
<211> 23
<212> PRT
<213> Artificial Sequence


<220> 
<223> C-terminal degron targeted by the CRL4B complex

<400> 445
Pro Lys Met Arg Trp Thr Ala Ser Gln Leu Leu Asp His Ser Phe Val 
1               5                   10                  15      
Lys Val Cys Thr Asp Glu Glu 
            20              

<210> 446
<211> 23
<212> PRT
<213> Artificial Sequence


<220> 
<223> C-terminal degron targeted by the CRL4B complex

<400> 446
Asn Trp Ser Asp Val Gly Lys Arg Lys Val Glu Ile Asn Pro Pro Asp 
1               5                   10                  15      
Asp Met Glu Trp Lys Lys Tyr 
            20              

<210> 447
<211> 23
<212> PRT
<213> Artificial Sequence


<220> 
<223> C-terminal degron targeted by the CRL4B complex

<400> 447
Gly Gln Tyr Gly Val Tyr Thr Lys Val Ile Asn Tyr Ile Pro Trp Ile 
1               5                   10                  15      
Glu Asn Ile Ile Ser Asp Phe 
            20              

<210> 448
<211> 23
<212> PRT
<213> Artificial Sequence


<220> 
<223> C-terminal degron targeted by the CRL4B complex

<400> 448
Pro Val Phe Ser Phe Pro Ser Leu Pro Lys Asp Leu Leu His Thr Thr 
1               5                   10                  15      
Pro Cys Phe Ile Pro Tyr His 
            20              

<210> 449
<211> 23
<212> PRT
<213> Artificial Sequence


<220> 
<223> C-terminal degron targeted by the CRL4B complex

<400> 449
Asn Ser His Arg Tyr Leu Gly Leu Lys Thr Arg Asn Ile Asn Gly Lys 
1               5                   10                  15      
Lys Met Val Tyr Leu Val Val 
            20              

<210> 450
<211> 23
<212> PRT
<213> Artificial Sequence


<220> 
<223> C-terminal degron targeted by the CRL4B complex

<400> 450
Glu Leu Pro Gly Arg Lys Tyr Ser Pro Gly Tyr Asn Thr Glu Val Gly 
1               5                   10                  15      
Asp Lys Trp Ile Trp Leu Lys 
            20              

<210> 451
<211> 23
<212> PRT
<213> Artificial Sequence


<220> 
<223> C-terminal degron targeted by the CRL4B complex

<400> 451
Asp His Pro Phe Leu Phe Val Ile Arg Lys Asp Asp Ile Ile Leu Phe 
1               5                   10                  15      
Ser Gly Lys Val Ser Cys Pro 
            20              

<210> 452
<211> 23
<212> PRT
<213> Artificial Sequence


<220> 
<223> C-terminal degron targeted by the CRL4B complex

<400> 452
Arg Asn Leu His Tyr Phe Asn Ser Asp Ser Phe Ala Ser His Pro Asn 
1               5                   10                  15      
Tyr Pro Tyr Ser Asp Glu Tyr 
            20              

<210> 453
<211> 23
<212> PRT
<213> Artificial Sequence


<220> 
<223> C-terminal degron targeted by the CRL4B complex

<400> 453
Leu Ala Ala Tyr Leu Glu Asn Arg Gln His Tyr Gln Met Ile Gln Arg 
1               5                   10                  15      
Glu Asp Gln Glu Thr Ala Val 
            20              

<210> 454
<211> 23
<212> PRT
<213> Artificial Sequence


<220> 
<223> C-terminal degron targeted by the CRL4B complex

<400> 454
Pro Val Pro Glu Ser Val Gln Glu Thr Asn Ser Ile Thr Val Tyr Ala 
1               5                   10                  15      
Ser Val Thr Leu Pro Glu Ser 
            20              

<210> 455
<211> 23
<212> PRT
<213> Artificial Sequence


<220> 
<223> C-terminal degron targeted by the CRL4B complex

<400> 455
Gly Ala Asp Glu His Leu Gln Leu Ile Ser Leu Cys Ala Thr Val Met 
1               5                   10                  15      
Gln Gln Leu Ser Gln Asn Cys 
            20              

<210> 456
<211> 23
<212> PRT
<213> Artificial Sequence


<220> 
<223> C-terminal degron targeted by the CRL4A and CRL4B complexes

<400> 456
Ser Thr Val Thr Ala Arg Arg Asn Pro Leu His Asn Pro Trp Gly Met 
1               5                   10                  15      
Glu Leu Ala Ala Ser Glu Glu 
            20              

<210> 457
<211> 23
<212> PRT
<213> Artificial Sequence


<220> 
<223> C-terminal degron targeted by the CRL4A and CRL4B complexes

<400> 457
Leu Leu Ser Ser Asn Cys Ser Thr Trp Lys Tyr Phe Ile Cys Glu Lys 
1               5                   10                  15      
Tyr Ala Leu Arg Ser Ser Val 
            20              

<210> 458
<211> 23
<212> PRT
<213> Artificial Sequence


<220> 
<223> C-terminal degron targeted by the CRL4A and CRL4B complexes

<400> 458
Leu Ala Val Thr Ile Ser Arg Glu Asn Ile Thr Glu Tyr Ala Ser Phe 
1               5                   10                  15      
Leu Pro Phe Phe Phe Leu Phe 
            20              

<210> 459
<211> 23
<212> PRT
<213> Artificial Sequence


<220> 
<223> C-terminal degron targeted by the CRL4A and CRL4B complexes

<400> 459
Ile Val Lys Glu Tyr Gly Asp Val Gly Ile Tyr Val Tyr Leu Ala Gly 
1               5                   10                  15      
Cys Ser Ala Phe Ile Gln Arg 
            20              

<210> 460
<211> 23
<212> PRT
<213> Artificial Sequence


<220> 
<223> C-terminal degron targeted by the CRL4A and CRL4B complexes

<400> 460
Gly Arg Ala Gly Ser Gly Ala Arg His Arg Pro Pro Arg Asp Arg Gly 
1               5                   10                  15      
Thr Pro Gly Leu Arg Thr His 
            20              

<210> 461
<211> 23
<212> PRT
<213> Artificial Sequence


<220> 
<223> C-terminal degron targeted by the CRL4A and CRL4B complexes

<400> 461
Asp Leu Ile Gln Gly Leu Thr Gly Glu Lys Pro Arg Ala Asp Asp Met 
1               5                   10                  15      
Lys Trp Ala Gln Lys Ile Lys 
            20              

<210> 462
<211> 23
<212> PRT
<213> Artificial Sequence


<220> 
<223> C-terminal degron targeted by the CRL4A and CRL4B complexes

<400> 462
Pro Pro Ala Gln Pro Thr Pro Gly Pro Pro Asp Asn Thr Leu Gln Glu 
1               5                   10                  15      
Thr Gly Thr Phe Pro Ser Ser 
            20              

<210> 463
<211> 23
<212> PRT
<213> Artificial Sequence


<220> 
<223> C-terminal degron targeted by the CRL4A and CRL4B complexes

<400> 463
Thr Ala Ser Ser His Glu Gln Pro Ala Ser Gly Leu Met Gln Gln Thr 
1               5                   10                  15      
Phe Gly Gln Gln Lys Leu Tyr 
            20              

<210> 464
<211> 23
<212> PRT
<213> Artificial Sequence


<220> 
<223> C-terminal degron targeted by the CRL4A and CRL4B complexes

<400> 464
Lys Leu Val Ser Ala Val Ser His Met His Asp Val Gly Val Val His 
1               5                   10                  15      
Arg Asp Leu Lys Pro Glu Val 
            20              

<210> 465
<211> 23
<212> PRT
<213> Artificial Sequence


<220> 
<223> C-terminal degron targeted by the CRL4A and CRL4B complexes

<400> 465
Ile Gly Phe Tyr Cys Thr Lys Ala Thr Val Thr Phe Lys Val Gly Leu 
1               5                   10                  15      
Phe Ser Cys Cys Leu Tyr Leu 
            20              

<210> 466
<211> 23
<212> PRT
<213> Artificial Sequence


<220> 
<223> C-terminal degron targeted by the CRL4A and CRL4B complexes

<400> 466
Met Ala Arg Ser Cys Arg Glu Lys Thr Arg His Gln Lys Ala Thr Cys 
1               5                   10                  15      
His Cys Gly Cys Ser Val Ala 
            20              

<210> 467
<211> 23
<212> PRT
<213> Artificial Sequence


<220> 
<223> C-terminal degron targeted by the CRL4A and CRL4B complexes

<400> 467
Tyr Pro Val Thr Trp Pro Gly Ser Gly Arg Glu Ala Phe Thr Asn Pro 
1               5                   10                  15      
Arg Ala Ile Ser Thr Asp Val 
            20              

<210> 468
<211> 23
<212> PRT
<213> Artificial Sequence


<220> 
<223> C-terminal degron targeted by the CRL4A and CRL4B complexes

<400> 468
Leu Leu Met Trp Ile Thr Gln Cys Phe Leu Pro Val Phe Leu Ala Gln 
1               5                   10                  15      
Ala Pro Ser Gly Gln Arg Arg 
            20              

<210> 469
<211> 23
<212> PRT
<213> Artificial Sequence


<220> 
<223> C-terminal degron targeted by the CRL4A and CRL4B complexes

<400> 469
Arg Arg Ser Ile His Ser Ser Gly Leu Thr Gly Asp Ser His Ser Gln 
1               5                   10                  15      
Asn Ile Leu Pro Val Ser Glu 
            20              

<210> 470
<211> 23
<212> PRT
<213> Artificial Sequence


<220> 
<223> C-terminal degron targeted by the CRL4A and CRL4B complexes

<400> 470
Cys Pro Gly Ala Thr Pro Glu Leu Phe Lys Tyr Phe Ser Gln His Leu 
1               5                   10                  15      
Pro Arg Cys Leu Val Ile Glu 
            20              

<210> 471
<211> 23
<212> PRT
<213> Artificial Sequence


<220> 
<223> C-terminal degron targeted by the CRL4A and CRL4B complexes

<400> 471
Met Arg Ser Asn Tyr Pro Pro Pro Leu Ser Ser Ala Ala Leu Arg Gly 
1               5                   10                  15      
Ala Gly Pro Thr Arg Arg Asn 
            20              

<210> 472
<211> 23
<212> PRT
<213> Artificial Sequence


<220> 
<223> C-terminal degron targeted by the CRL4A and CRL4B complexes

<400> 472
Leu Thr Ala Ser Glu Val Ile Asn Pro Leu Ile Glu Glu Leu Gly Cys 
1               5                   10                  15      
Asp Lys Phe Ile Asn Arg Glu 
            20              

<210> 473
<211> 23
<212> PRT
<213> Artificial Sequence


<220> 
<223> C-terminal degron targeted by the CRL4A and CRL4B complexes

<400> 473
Cys Ser Lys Ser Phe Arg Gln Arg Ala Gly Leu Ile Met His Gln Val 
1               5                   10                  15      
Thr His Phe Arg Gly Leu Ile 
            20              

<210> 474
<211> 23
<212> PRT
<213> Artificial Sequence


<220> 
<223> C-terminal degron targeted by the CRL4A and CRL4B complexes

<400> 474
Phe Ser Ser Tyr Val Phe Arg Asn Ser Ser Leu Phe Ala Leu Ala Asn 
1               5                   10                  15      
Val Tyr Ala Val Tyr Leu Glu 
            20              

<210> 475
<211> 23
<212> PRT
<213> Artificial Sequence


<220> 
<223> C-terminal degron targeted by the CRL4A and CRL4B complexes

<400> 475
Gln Gly Ala Met Asn Gln Pro Gln Thr Gln Tyr Ser Ala Thr Pro Asn 
1               5                   10                  15      
Tyr Thr Tyr Ser Asn Glu Met 
            20              

<210> 476
<211> 23
<212> PRT
<213> Artificial Sequence


<220> 
<223> C-terminal degron targeted by the CRL4A and CRL4B complexes

<400> 476
Trp Phe Glu Lys Met Thr Cys Tyr Leu Gln Leu Leu Phe Asn Ile Cys 
1               5                   10                  15      
Leu Pro Asp Val Ser Glu Glu 
            20              

<210> 477
<211> 23
<212> PRT
<213> Artificial Sequence


<220> 
<223> C-terminal degron targeted by the CRL4A and CRL4B complexes

<400> 477
Ala Leu Glu Asn Lys Met Arg Asn Lys Lys Met Ala Ala Ala Arg Ala 
1               5                   10                  15      
Ala Ala Ala Ala Gly Arg Gln 
            20              

<210> 478
<211> 23
<212> PRT
<213> Artificial Sequence


<220> 
<223> C-terminal degron targeted by the CRL4A and CRL4B complexes

<400> 478
Tyr Ser Thr Val Val Ile Val Phe Ala Pro Asn Leu Trp Gly Arg His 
1               5                   10                  15      
Ala Val Phe Pro Ile Ser Arg 
            20              

<210> 479
<211> 23
<212> PRT
<213> Artificial Sequence


<220> 
<223> C-terminal degron targeted by the CRL4A and CRL4B complexes

<400> 479
Ala Ala Val Pro Ala Pro Pro Pro Glu Pro Glu Gly Gln Asp Pro Pro 
1               5                   10                  15      
Ala Pro Ser Gln Asp Thr Ser 
            20              

<210> 480
<211> 23
<212> PRT
<213> Artificial Sequence


<220> 
<223> C-terminal degron targeted by the CRL4A and CRL4B complexes

<400> 480
Lys Gln Arg Met Ile Cys Glu Lys Met Ala Asn Pro Val Gln Leu Gly 
1               5                   10                  15      
Ser Thr Tyr Phe Arg Glu Ala 
            20              

<210> 481
<211> 23
<212> PRT
<213> Artificial Sequence


<220> 
<223> C-terminal degron targeted by the CRL4A and CRL4B complexes

<400> 481
Lys Lys Leu Asn Ala Lys Gly Val Arg Thr Leu Ser Arg Cys Arg Trp 
1               5                   10                  15      
Lys Lys Phe Phe Cys Phe Val 
            20              

<210> 482
<211> 23
<212> PRT
<213> Artificial Sequence


<220> 
<223> C-terminal degron targeted by the CRL4A and CRL4B complexes

<400> 482
Ser Asp Tyr Cys Leu Pro Val Ala Asp Tyr Asn Tyr Asn Pro His Pro 
1               5                   10                  15      
Arg Gly Trp Arg Arg Gln Thr 
            20              

<210> 483
<211> 23
<212> PRT
<213> Artificial Sequence


<220> 
<223> C-terminal degron targeted by the CRL4A and CRL4B complexes

<400> 483
Leu Lys Gln Ile Met Asp Gln Leu Arg Asn Leu Ile Trp Asp Ile Asn 
1               5                   10                  15      
Ala Met Leu Ala Met Arg Asn 
            20              

<210> 484
<211> 23
<212> PRT
<213> Artificial Sequence


<220> 
<223> C-terminal degron targeted by the CRL4A and CRL4B complexes

<400> 484
Leu His Leu Glu Asp Lys Val Ser Ser Val Pro Asp Asn Tyr Arg Thr 
1               5                   10                  15      
Ser Asn Tyr Ile Tyr Asn Phe 
            20              

<210> 485
<211> 23
<212> PRT
<213> Artificial Sequence


<220> 
<223> C-terminal degron targeted by the CRL4A and CRL4B complexes

<400> 485
Ser Ser Leu Arg Cys Cys Cys Gly Ser Thr Gly Trp Gly Cys Pro Ser 
1               5                   10                  15      
Arg Thr Ile Ala Gln Ala Cys 
            20              

<210> 486
<211> 23
<212> PRT
<213> Artificial Sequence


<220> 
<223> C-terminal degron targeted by the CRL4A and CRL4B complexes

<400> 486
Ile Arg Arg Val Phe Asn Asp Cys Arg Asp Ile Ile Gln Arg Met His 
1               5                   10                  15      
Leu Arg Gln Tyr Glu Leu Leu 
            20              

<210> 487
<211> 23
<212> PRT
<213> Artificial Sequence


<220> 
<223> C-terminal degron targeted by the CRL4A and CRL4B complexes

<400> 487
Asp Pro Leu Leu Val Gly Val Pro Ala Ser Glu Asn Pro Phe Lys Asp 
1               5                   10                  15      
Lys Lys Pro Cys Ile Ile Leu 
            20              

<210> 488
<211> 23
<212> PRT
<213> Artificial Sequence


<220> 
<223> C-terminal degron targeted by the CRL4A and CRL4B complexes

<400> 488
Asn Val Ala Ile Pro Arg Phe His Met Ala Cys Pro Thr Phe Arg Val 
1               5                   10                  15      
Ser Ile Ala Arg Leu Val Ser 
            20              

<210> 489
<211> 23
<212> PRT
<213> Artificial Sequence


<220> 
<223> C-terminal degron targeted by the CRL4A and CRL4B complexes

<400> 489
Asn Leu Val Met Tyr Pro Lys Leu Gly Tyr Val Ile Tyr Ser Arg Ser 
1               5                   10                  15      
Val Leu Cys Asn Trp Ile Ile 
            20              

<210> 490
<211> 23
<212> PRT
<213> Artificial Sequence


<220> 
<223> C-terminal degron targeted by the CRL4A and CRL4B complexes

<400> 490
Ala Val Thr Met Thr Pro Thr Arg Leu Lys Trp Ser Glu Gly Lys Lys 
1               5                   10                  15      
Glu Gly Lys Lys Gly Phe Leu 
            20              

<210> 491
<211> 23
<212> PRT
<213> Artificial Sequence


<220> 
<223> C-terminal degron targeted by the CRL4A and CRL4B complexes

<400> 491
Thr Val Val Arg His Asp Ala Glu Leu Arg Val Pro Ser Pro Thr Glu 
1               5                   10                  15      
Glu Pro Tyr Ala Pro Glu Leu 
            20              

<210> 492
<211> 23
<212> PRT
<213> Artificial Sequence


<220> 
<223> C-terminal degron targeted by the CRL4A and CRL4B complexes

<400> 492
Val Asp Ile Ser Ala Thr Asn Ala Ile Gly Cys Leu Ile Ser Ala Phe 
1               5                   10                  15      
Val Phe Leu Val His Leu Val 
            20              

<210> 493
<211> 23
<212> PRT
<213> Artificial Sequence


<220> 
<223> C-terminal degron targeted by the CRL4A and CRL4B complexes

<400> 493
Pro Glu Arg Trp Gln Lys Leu Glu Ser Val Leu Pro Pro Glu Arg Leu 
1               5                   10                  15      
Pro Val Gln Arg Glu Glu Glu 
            20              

<210> 494
<211> 23
<212> PRT
<213> Artificial Sequence


<220> 
<223> C-terminal degron targeted by the CRL4A and CRL4B complexes

<400> 494
Trp Asp Leu Gly Arg His Phe Glu Cys Ala Val Ala Lys Leu Tyr Pro 
1               5                   10                  15      
Gln Cys Leu Gln Lys Val Leu 
            20              

<210> 495
<211> 23
<212> PRT
<213> Artificial Sequence


<220> 
<223> C-terminal degron targeted by the CRL4A and CRL4B complexes

<400> 495
Arg Glu Thr Ile Arg Asn Gly Ser Leu Pro Leu Ser Met Ser His Pro 
1               5                   10                  15      
Tyr Cys Gly Pro Leu Ala Asn 
            20              

<210> 496
<211> 23
<212> PRT
<213> Artificial Sequence


<220> 
<223> C-terminal degron targeted by the CRL4A and CRL4B complexes

<400> 496
Val Ser Val Gln Ala Ala Gly Thr Gln Ser Ser Tyr Pro Tyr Lys Lys 
1               5                   10                  15      
Asp Leu Pro Leu Thr Leu Phe 
            20              

<210> 497
<211> 23
<212> PRT
<213> Artificial Sequence


<220> 
<223> C-terminal degron targeted by the CRL4A and CRL4B complexes

<400> 497
Val Pro Asp Gly Leu Gly Leu Asp Glu Ala Arg Glu Glu Glu Gly Asp 
1               5                   10                  15      
Arg Glu Val Val Leu Tyr Gly 
            20              

<210> 498
<211> 23
<212> PRT
<213> Artificial Sequence


<220> 
<223> C-terminal degron targeted by the CRL4A and CRL4B complexes

<400> 498
Cys Ala Thr Thr Asn Ala Ser Gly Asn Ser Cys Gly Pro Cys Gly Thr 
1               5                   10                  15      
Ser Gln Lys Gly Cys Cys Asn 
            20              

<210> 499
<211> 23
<212> PRT
<213> Artificial Sequence


<220> 
<223> C-terminal degron targeted by the CRL4A and CRL4B complexes

<400> 499
Val Arg Ala Glu Ile Met Arg Ser Phe Ser Ser Ser Arg Asn Leu Gln 
1               5                   10                  15      
Glu Arg Leu Arg Arg Lys Glu 
            20              

<210> 500
<211> 23
<212> PRT
<213> Artificial Sequence


<220> 
<223> C-terminal degron targeted by the CRL4A and CRL4B complexes

<400> 500
Lys Ala Phe Arg Ser Ser Ser Ser Leu Thr Val His Gln Arg Ile His 
1               5                   10                  15      
Gln Arg Glu Thr Gln Leu Ile 
            20              

<210> 501
<211> 23
<212> PRT
<213> Artificial Sequence


<220> 
<223> C-terminal degron targeted by the CRL4A and CRL4B complexes

<400> 501
Leu Met Ala Ser Leu Thr Asn Met Ser Arg Ser Ser Pro Ser Glu Leu 
1               5                   10                  15      
Ser Leu Asn Asp Ser Leu Arg 
            20              

<210> 502
<211> 23
<212> PRT
<213> Artificial Sequence


<220> 
<223> C-terminal degron targeted by the CRL4A and CRL4B complexes

<400> 502
Arg Ser Ala Arg Ser Gly Gly Gly Arg Trp Arg Pro Asn Ala Pro Arg 
1               5                   10                  15      
Gly Arg Trp Pro Arg Ala Pro 
            20              

<210> 503
<211> 23
<212> PRT
<213> Artificial Sequence


<220> 
<223> C-terminal degron targeted by the CRL4A and CRL4B complexes

<400> 503
Ala Thr Phe Leu Ile Asp Tyr Met Phe Phe Glu Lys Arg Gly Gly Ala 
1               5                   10                  15      
Gly Pro Ser Ala Val Thr Ser 
            20              

<210> 504
<211> 23
<212> PRT
<213> Artificial Sequence


<220> 
<223> C-terminal degron targeted by the CRL4A and CRL4B complexes

<400> 504
Leu Ile Tyr Thr Ile Pro Asn Cys Ser Phe Ser Pro Pro Leu Arg Pro 
1               5                   10                  15      
Ile Phe Cys Cys Ile His Phe 
            20              

<210> 505
<211> 23
<212> PRT
<213> Artificial Sequence


<220> 
<223> C-terminal degron targeted by the CRL4A and CRL4B complexes

<400> 505
Ile Leu Thr Lys Lys Asn Asp Gln Ile Lys Asp Leu Arg Lys Arg Leu 
1               5                   10                  15      
Ala Gln Tyr Glu Pro Glu Asp 
            20              

<210> 506
<211> 23
<212> PRT
<213> Artificial Sequence


<220> 
<223> C-terminal degron targeted by the CRL4A and CRL4B complexes

<400> 506
Val Asp Glu Gly Asp Glu Gly Ser Met Pro Ala Asp Ile Ala Thr Leu 
1               5                   10                  15      
Leu Lys Thr Ser Met Gly Leu 
            20              

<210> 507
<211> 23
<212> PRT
<213> Artificial Sequence


<220> 
<223> C-terminal degron targeted by the CRL4A and CRL4B complexes

<400> 507
Phe Val Pro Ser Ala Gly Thr Asp Ser Lys Thr Cys Asn Leu Asp Met 
1               5                   10                  15      
Gln Asp Asn Ala Ala Ala Asn 
            20              

<210> 508
<211> 23
<212> PRT
<213> Artificial Sequence


<220> 
<223> C-terminal degron targeted by the CRL4A and CRL4B complexes

<400> 508
Glu Asn Ala Ser Asp Tyr Leu Ala Ile Pro Ser Glu Asn Lys Glu Asn 
1               5                   10                  15      
Ser Ala Val Pro Val Glu Glu 
            20              

<210> 509
<211> 23
<212> PRT
<213> Artificial Sequence


<220> 
<223> C-terminal degron targeted by the CRL4A and CRL4B complexes

<400> 509
Val Pro Ser Ala Gly Val Ile Leu Gly Cys Ala Lys Ser Pro Trp Met 
1               5                   10                  15      
Met Ala Ile Gly Phe Pro Ile 
            20              

<210> 510
<211> 23
<212> PRT
<213> Artificial Sequence


<220> 
<223> C-terminal degron targeted by the CRL4A and CRL4B complexes

<400> 510
Pro Lys Val Leu Glu Glu Met Glu Ser Arg Phe Glu Lys Met Arg Ser 
1               5                   10                  15      
Ala Lys Arg Arg Gln Gln Thr 
            20              

<210> 511
<211> 23
<212> PRT
<213> Artificial Sequence


<220> 
<223> C-terminal degron targeted by the CRL4A and CRL4B complexes

<400> 511
Ser Gly Val Thr Met Glu Phe Thr Ile Gln Asp Ile Leu Asp Tyr Cys 
1               5                   10                  15      
Ser Ser Ile Ala Gln Ser His 
            20              

<210> 512
<211> 23
<212> PRT
<213> Artificial Sequence


<220> 
<223> C-terminal degron targeted by the CRL4A and CRL4B complexes

<400> 512
Lys Glu Lys Gln Cys Asn Phe Phe Gln Trp Ala Glu Asn Gly Pro Gly 
1               5                   10                  15      
Ile Lys Ile Ile Pro Gly Cys 
            20              

<210> 513
<211> 23
<212> PRT
<213> Artificial Sequence


<220> 
<223> C-terminal degron targeted by the CRL4A and CRL4B complexes

<400> 513
Arg Tyr Asn Tyr Ile Glu Gly Thr Lys Met Leu Ala Ala Tyr Leu Tyr 
1               5                   10                  15      
Glu Val Ser Gln Leu Lys Asp 
            20              

<210> 514
<211> 23
<212> PRT
<213> Artificial Sequence


<220> 
<223> C-terminal degron targeted by the CRL4A and CRL4B complexes

<400> 514
Asn Ile Ile Phe Gly Glu Cys Pro Tyr Cys Ser Lys Pro Ile Thr Leu 
1               5                   10                  15      
Lys Met Ser Gly Arg Lys His 
            20              

<210> 515
<211> 23
<212> PRT
<213> Artificial Sequence


<220> 
<223> C-terminal degron targeted by the CRL4A and CRL4B complexes

<400> 515
Lys Pro Ile Asp Val Lys Ala Lys Leu Glu Asn Ala Arg Ile Ser Gln 
1               5                   10                  15      
Leu Arg Ser Arg Thr Lys Met 
            20              

<210> 516
<211> 23
<212> PRT
<213> Artificial Sequence


<220> 
<223> C-terminal degron targeted by the CRL4A and CRL4B complexes

<400> 516
Asn Ile Gln Arg Asn Pro Lys Glu Gly Leu Leu Cys Ala Ser Ser Pro 
1               5                   10                  15      
Ala Ser Cys Cys His Val Ile 
            20              

<210> 517
<211> 23
<212> PRT
<213> Artificial Sequence


<220> 
<223> C-terminal degron targeted by the CRL4A and CRL4B complexes

<400> 517
Ala Glu Ser Gln Val Asn Lys Leu Arg Val Lys Ser Arg Glu Val His 
1               5                   10                  15      
Thr Lys Val Ile Ser Glu Glu 
            20              

<210> 518
<211> 23
<212> PRT
<213> Artificial Sequence


<220> 
<223> C-terminal degron targeted by the CRL4A and CRL4B complexes

<400> 518
Ala Glu Ser Gln Val Asn Lys Leu Arg Val Lys Ser Arg Glu Val His 
1               5                   10                  15      
Thr Lys Val Ile Ser Glu Glu 
            20              

<210> 519
<211> 23
<212> PRT
<213> Artificial Sequence


<220> 
<223> C-terminal degron targeted by the CRL4A and CRL4B complexes

<400> 519
His Arg Pro Ser Pro Ala Lys Thr Asn Lys Glu Arg Ala Arg Gly Asp 
1               5                   10                  15      
His Arg Gly Trp Arg Asn Phe 
            20              

<210> 520
<211> 23
<212> PRT
<213> Artificial Sequence


<220> 
<223> C-terminal degron targeted by the CRL4A and CRL4B complexes

<400> 520
Gln Gln Arg Asp Trp Ile Thr Leu Pro Ser Glu Lys Leu Phe Met Asp 
1               5                   10                  15      
Arg Asn Leu Thr Thr Thr Ser 
            20              

<210> 521
<211> 23
<212> PRT
<213> Artificial Sequence


<220> 
<223> C-terminal degron targeted by the CRL4A and CRL4B complexes

<400> 521
Thr Leu Ser Pro Glu Lys Tyr His Ala Leu Cys Ser Gln Thr Gln Val 
1               5                   10                  15      
Met Glu Val Gly Asn Glu Glu 
            20              

<210> 522
<211> 23
<212> PRT
<213> Artificial Sequence


<220> 
<223> C-terminal degron targeted by the CRL4A and CRL4B complexes

<400> 522
His Arg Gln Lys Gln Asn Thr Gly His Tyr Ser Ser Asp Asn Thr Thr 
1               5                   10                  15      
Arg Ala Ser Thr Arg Leu Ile 
            20              

<210> 523
<211> 23
<212> PRT
<213> Artificial Sequence


<220> 
<223> C-terminal degron targeted by the CRL4A and CRL4B complexes

<400> 523
Ala Tyr Gly Leu Gly Glu His Tyr Asn Ser Val Thr Arg Leu Val Asn 
1               5                   10                  15      
Ile Val Thr Glu Asn Cys Ser 
            20              

<210> 524
<211> 23
<212> PRT
<213> Artificial Sequence


<220> 
<223> C-terminal degron targeted by the CRL4A and CRL4B complexes

<400> 524
Tyr Gly Val Ser Asn Leu Gln Glu Phe Arg Tyr Gly Leu Glu Gly Gly 
1               5                   10                  15      
Cys Thr Asp Asp Thr Leu Leu 
            20              

<210> 525
<211> 23
<212> PRT
<213> Artificial Sequence


<220> 
<223> C-terminal degron targeted by the CRL4A and CRL4B complexes

<400> 525
Thr Ser Ala Pro Trp Asp Pro Leu Pro Gly Pro Pro Pro Val Leu Pro 
1               5                   10                  15      
His Ser Pro His Ser His Leu 
            20              

<210> 526
<211> 23
<212> PRT
<213> Artificial Sequence


<220> 
<223> C-terminal degron targeted by the CRL4A and CRL4B complexes

<400> 526
Leu Ile Glu Val Asn Glu Glu Val Lys Lys Leu Cys Ala Thr Gln Phe 
1               5                   10                  15      
Asn Asn Ile Phe Phe Leu Asp 
            20              

<210> 527
<211> 23
<212> PRT
<213> Artificial Sequence


<220> 
<223> C-terminal degron targeted by the CRL4A and CRL4B complexes

<400> 527
Gly Ile Ser Val Ser Leu Ser Leu Pro Ser Leu Pro Ser Arg Arg Gly 
1               5                   10                  15      
Arg Cys Gly Arg Ile Ile Gly 
            20              

<210> 528
<211> 23
<212> PRT
<213> Artificial Sequence


<220> 
<223> C-terminal degron targeted by the CRL4A and CRL4B complexes

<400> 528
Gly Leu Val Lys Ala Ala Arg Arg Gly Ser Gln Val Gly His Lys Asn 
1               5                   10                  15      
Arg Arg Lys Asp Arg Arg Pro 
            20              

<210> 529
<211> 23
<212> PRT
<213> Artificial Sequence


<220> 
<223> C-terminal degron targeted by the CRL4A and CRL4B complexes

<400> 529
Thr Pro Leu Thr Arg Arg Ala Ser Gln Ser Ser Leu Glu Ser Ser Thr 
1               5                   10                  15      
Gly Pro Pro Cys Ile Arg Ser 
            20              

<210> 530
<211> 23
<212> PRT
<213> Artificial Sequence


<220> 
<223> C-terminal degron targeted by the CRL4A and CRL4B complexes

<400> 530
Ile Leu Thr Ser Val Pro Gly Thr Ile Arg Ser Gly Ser Leu Ser Val 
1               5                   10                  15      
Ala Ser Ala Arg Leu Cys Gly 
            20              

<210> 531
<211> 23
<212> PRT
<213> Artificial Sequence


<220> 
<223> C-terminal degron targeted by the CRL4A and CRL4B complexes

<400> 531
Asn Ala Ile Arg Arg Gly Val Lys Leu Lys Lys Thr Thr Thr Asn Asp 
1               5                   10                  15      
Arg Ser Ala Pro Arg Phe Ser 
            20              

<210> 532
<211> 23
<212> PRT
<213> Artificial Sequence


<220> 
<223> C-terminal degron targeted by the CRL4A and CRL4B complexes

<400> 532
Leu Glu Pro Lys Glu Ser Arg Ser Pro Gln Gln Val Gly Pro Thr Trp 
1               5                   10                  15      
Arg Pro Ala Glu Pro Glu Leu 
            20              

<210> 533
<211> 23
<212> PRT
<213> Artificial Sequence


<220> 
<223> C-terminal degron targeted by the CRL4A and CRL4B complexes

<400> 533
Leu Asp Lys Gly Val Val Thr Tyr Lys Phe Lys Tyr Glu Gly Met Ala 
1               5                   10                  15      
Val Ser Glu Cys Gly Cys Arg 
            20              

<210> 534
<211> 23
<212> PRT
<213> Artificial Sequence


<220> 
<223> C-terminal degron targeted by the CRL4A and CRL4B complexes

<400> 534
Arg Leu Ser Ile Gln Thr Asp Ser Pro Val Trp Val Ile Leu Ser Glu 
1               5                   10                  15      
Ile Phe Leu Lys Lys Ala Asp 
            20              

<210> 535
<211> 23
<212> PRT
<213> Artificial Sequence


<220> 
<223> C-terminal degron targeted by the CRL4A and CRL4B complexes

<400> 535
Lys Lys Val Ser Gln Gln Ile Leu Glu Lys Arg Ala Tyr Ile Cys Ala 
1               5                   10                  15      
His Pro Leu Asp Arg Thr Cys 
            20              

<210> 536
<211> 23
<212> PRT
<213> Artificial Sequence


<220> 
<223> C-terminal degron targeted by the CRL4A and CRL4B complexes

<400> 536
Leu Ser Lys Ser Glu Glu Lys Glu Leu Arg Lys Phe Arg Lys Ile Asp 
1               5                   10                  15      
Tyr Ser Trp Ile Ala Ala Leu 
            20              

<210> 537
<211> 23
<212> PRT
<213> Artificial Sequence


<220> 
<223> C-terminal degron targeted by the CRL4A and CRL4B complexes

<400> 537
Ala Asn Gly Ala Leu Phe Val Ala Tyr Glu Tyr Ser Arg Lys Met Met 
1               5                   10                  15      
Met Lys Gln Leu Glu Ala Tyr 
            20              

<210> 538
<211> 23
<212> PRT
<213> Artificial Sequence


<220> 
<223> C-terminal degron targeted by the CRL4A and CRL4B complexes

<400> 538
Pro Gln Cys Pro Gly Leu Leu Val Ser Thr Ala Leu Ser Gly Phe Thr 
1               5                   10                  15      
Ile Phe Arg Thr Ile Ser Val 
            20              

<210> 539
<211> 23
<212> PRT
<213> Artificial Sequence


<220> 
<223> C-terminal degron targeted by the CRL4A and CRL4B complexes

<400> 539
Ser Asn Phe Glu Glu Ala Arg Thr Ser Tyr Gly Thr Asp Glu Asp Ile 
1               5                   10                  15      
Leu Phe Val Tyr Leu Asp Ser 
            20              

<210> 540
<211> 23
<212> PRT
<213> Artificial Sequence


<220> 
<223> C-terminal degron targeted by the CRL4A and CRL4B complexes

<400> 540
Leu Asn Leu Glu Met Asn Asn Asn Lys Ile Glu Ala Asn Val Lys Gly 
1               5                   10                  15      
Asp Ile Arg Ile Val Thr Ser 
            20              

<210> 541
<211> 23
<212> PRT
<213> Artificial Sequence


<220> 
<223> C-terminal degron targeted by the CRL4A and CRL4B complexes

<400> 541
Lys Phe His Trp Cys Cys Phe Val Arg Cys Lys Lys Cys Thr Glu Ile 
1               5                   10                  15      
Val Asp Gln Tyr Ile Cys Lys 
            20              

<210> 542
<211> 23
<212> PRT
<213> Artificial Sequence


<220> 
<223> C-terminal degron targeted by the CRL4A and CRL4B complexes

<400> 542
Arg Arg Asn Gln Glu Lys Phe Ser Ser Ile Ser Leu Ser Glu Leu Ile 
1               5                   10                  15      
His Arg Ser Lys Ser Glu Glu 
            20              

<210> 543
<211> 23
<212> PRT
<213> Artificial Sequence


<220> 
<223> C-terminal degron targeted by the CRL4A and CRL4B complexes

<400> 543
Leu Glu Lys His Ile Val Arg His Gly Arg Pro Pro Pro Cys Lys Lys 
1               5                   10                  15      
Gln Pro Gln Ala Arg Leu Asn 
            20              

<210> 544
<211> 23
<212> PRT
<213> Artificial Sequence


<220> 
<223> C-terminal degron targeted by the CRL4A and CRL4B complexes

<400> 544
Glu Glu Lys Leu Arg Tyr Ala Ala Tyr Asn Cys Val Ala Ile Asp Thr 
1               5                   10                  15      
Asp Met Ser Pro Trp Glu Glu 
            20              

<210> 545
<211> 23
<212> PRT
<213> Artificial Sequence


<220> 
<223> C-terminal degron targeted by the CRL4A and CRL4B complexes

<400> 545
Tyr Gly Phe Ser Thr Ser Gln Pro Thr His Met Arg Gly Trp Thr Tyr 
1               5                   10                  15      
Leu Thr Gly Ile Gln Glu Ser 
            20              

<210> 546
<211> 23
<212> PRT
<213> Artificial Sequence


<220> 
<223> C-terminal degron targeted by the CRL4A and CRL4B complexes

<400> 546
Gly Ser Pro Ser Arg Arg Lys Ala Ala Ser Gln Pro Thr Ser Leu Ala 
1               5                   10                  15      
Pro Glu Lys Leu Arg Glu Glu 
            20              

<210> 547
<211> 23
<212> PRT
<213> Artificial Sequence


<220> 
<223> C-terminal degron targeted by the CRL4A and CRL4B complexes

<400> 547
Asn Arg Trp Tyr Gln Asp Leu Asp Lys Ile Asp Gln Lys Asp Leu Met 
1               5                   10                  15      
His Lys Val Lys Thr Glu Leu 
            20              

<210> 548
<211> 23
<212> PRT
<213> Artificial Sequence


<220> 
<223> C-terminal degron targeted by the CRL4A and CRL4B complexes

<400> 548
Pro His Ala Glu Gln Arg Gln Pro Thr Lys Lys Met Ser Lys Val Lys 
1               5                   10                  15      
Gly Leu Val Ser Ser Arg His 
            20              

<210> 549
<211> 23
<212> PRT
<213> Artificial Sequence


<220> 
<223> C-terminal degron targeted by the CRL4A and CRL4B complexes

<400> 549
Met Leu Ala Pro Asp Pro Asp Pro Asn Gly Glu Leu Leu Pro Gly Ser 
1               5                   10                  15      
Pro Asn Pro Glu Glu Pro Ile 
            20              

<210> 550
<211> 23
<212> PRT
<213> Artificial Sequence


<220> 
<223> C-terminal degron targeted by the CRL4A and CRL4B complexes

<400> 550
Val Arg Lys Leu Gln Ala Asn Lys Lys Val Gln Gly Ser Arg Arg Arg 
1               5                   10                  15      
Leu Arg Glu Gly Arg Ser Gln 
            20              

<210> 551
<211> 23
<212> PRT
<213> Artificial Sequence


<220> 
<223> C-terminal degron targeted by the CRL4A and CRL4B complexes

<400> 551
Thr Ser Asp Gly His Val Val Val Ala Asp Ala Gly Asn His Cys Phe 
1               5                   10                  15      
Lys Ala Tyr Arg Tyr Leu Gln 
            20              

<210> 552
<211> 23
<212> PRT
<213> Artificial Sequence


<220> 
<223> C-terminal degron targeted by the CRL4A and CRL4B complexes

<400> 552
Ile Ala Arg Arg Thr Ala Gln Lys Ile Met Ala Pro Pro Gly Gly Arg 
1               5                   10                  15      
Ser Asn Ile Thr Ser Leu Ser 
            20              

<210> 553
<211> 23
<212> PRT
<213> Artificial Sequence


<220> 
<223> C-terminal degron targeted by the CRL4A and CRL4B complexes

<400> 553
Glu Pro Ala Asp Thr Ala Leu Leu Leu Asp Asn Met Lys Lys Ala Leu 
1               5                   10                  15      
Lys Leu Leu Lys Thr Glu Leu 
            20              

<210> 554
<211> 23
<212> PRT
<213> Artificial Sequence


<220> 
<223> C-terminal degron targeted by the CRL4A and CRL4B complexes

<400> 554
Ser Glu Asn Ile Lys Glu Ile Arg Asp Lys Tyr Glu Lys Lys Ala Thr 
1               5                   10                  15      
Leu Ile Lys Ser Ser Glu Glu 
            20              

<210> 555
<211> 23
<212> PRT
<213> Artificial Sequence


<220> 
<223> C-terminal degron targeted by the CRL4A and CRL4B complexes

<400> 555
Ala Glu Ser Gln Val Asn Lys Leu Arg Val Lys Ser Arg Glu Val His 
1               5                   10                  15      
Thr Lys Ile Ile Ser Glu Glu 
            20              

<210> 556
<211> 23
<212> PRT
<213> Artificial Sequence


<220> 
<223> C-terminal degron targeted by the CRL4A and CRL4B complexes

<400> 556
Phe Asn Ser Glu Ala His Leu Leu Pro Ile Leu Pro Lys Asp Lys Lys 
1               5                   10                  15      
Glu Val Glu Ile Arg Glu Glu 
            20              

<210> 557
<211> 23
<212> PRT
<213> Artificial Sequence


<220> 
<223> C-terminal degron targeted by the CRL4A and CRL4B complexes

<400> 557
His Pro Phe Leu Ala Lys Ala Gly Pro Pro Ala Ser Ile Val Pro Leu 
1               5                   10                  15      
Met Arg Gln Asn Arg Thr Arg 
            20              

<210> 558
<211> 23
<212> PRT
<213> Artificial Sequence


<220> 
<223> C-terminal degron targeted by the CRL4A and CRL4B complexes

<400> 558
Leu Arg Pro Asp Phe Phe Asp Ser Ala Ala Ile Ile Glu Asp Asp Ser 
1               5                   10                  15      
Gly Phe Gly Met Pro Met Phe 
            20              

<210> 559
<211> 23
<212> PRT
<213> Artificial Sequence


<220> 
<223> C-terminal degron targeted by the CRL4A and CRL4B complexes

<400> 559
Lys Glu Val Tyr Asp Ile Ala Phe Ser Arg Ala Gly Gly Trp Gln Gly 
1               5                   10                  15      
His Val Cys Leu Cys Gly Cys 
            20              

<210> 560
<211> 23
<212> PRT
<213> Artificial Sequence


<220> 
<223> C-terminal degron targeted by the CRL4A and CRL4B complexes

<400> 560
Ile Gln Ala Tyr Ser Glu Ser Leu Met Thr Ser Ala Pro Lys Gly Ser 
1               5                   10                  15      
Val Leu Gln Glu Ala Lys Leu 
            20              

<210> 561
<211> 23
<212> PRT
<213> Artificial Sequence


<220> 
<223> C-terminal degron targeted by the CRL4A and CRL4B complexes

<400> 561
Asn Glu Lys Phe Asp Lys His Tyr Glu Gln Gln Met Lys Glu Ser Thr 
1               5                   10                  15      
Leu Lys Phe Arg Thr Glu Ile 
            20              

<210> 562
<211> 23
<212> PRT
<213> Artificial Sequence


<220> 
<223> C-terminal degron targeted by the CRL4A and CRL4B complexes

<400> 562
Lys Ile Ser Gly Gly Pro His Ile Ser Tyr Pro Pro Leu His Glu Trp 
1               5                   10                  15      
Ala Phe Arg Glu Gly Glu Glu 
            20              

<210> 563
<211> 23
<212> PRT
<213> Artificial Sequence


<220> 
<223> C-terminal degron targeted by the CRL4A and CRL4B complexes

<400> 563
Lys Ile Ser Gly Gly Pro Arg Ile Ser Tyr Pro Leu Leu His Glu Trp 
1               5                   10                  15      
Ala Leu Arg Glu Gly Glu Glu 
            20              

<210> 564
<211> 23
<212> PRT
<213> Artificial Sequence


<220> 
<223> C-terminal degron targeted by the CRL4A and CRL4B complexes

<400> 564
Lys Ile Ser Gly Gly Pro His Ile Ser Tyr Pro Pro Leu His Glu Trp 
1               5                   10                  15      
Val Leu Arg Glu Gly Glu Glu 
            20              

<210> 565
<211> 23
<212> PRT
<213> Artificial Sequence


<220> 
<223> C-terminal degron targeted by the CRL4A and CRL4B complexes

<400> 565
Lys Ile Gly Gly Glu Pro His Ile Ser Tyr Pro Pro Leu His Glu Arg 
1               5                   10                  15      
Ala Leu Arg Glu Gly Glu Glu 
            20              

<210> 566
<211> 23
<212> PRT
<213> Artificial Sequence


<220> 
<223> C-terminal degron targeted by the CRL4A and CRL4B complexes

<400> 566
Gln Asn Glu Asp Leu Val Leu Thr Gly Tyr Gln Val Asp Lys Asn Lys 
1               5                   10                  15      
Asp Asp Glu Leu Thr Gly Phe 
            20              

<210> 567
<211> 23
<212> PRT
<213> Artificial Sequence


<220> 
<223> C-terminal degron targeted by the CRL4A and CRL4B complexes

<400> 567
Val Ile Leu Leu Asp Glu Ala Leu Lys Tyr Leu Ser Arg Asn His Met 
1               5                   10                  15      
His Glu Glu Met Ser Gln Lys 
            20              

<210> 568
<211> 23
<212> PRT
<213> Artificial Sequence


<220> 
<223> C-terminal degron targeted by the CRL4A and CRL4B complexes

<400> 568
Cys Ala Ser Pro Pro Glu Val Val Gly Leu Asp Leu Arg Asp Leu Ser 
1               5                   10                  15      
Glu Ala His Phe Ala Pro Cys 
            20              

<210> 569
<211> 23
<212> PRT
<213> Artificial Sequence


<220> 
<223> C-terminal degron targeted by the CRL4A and CRL4B complexes

<400> 569
Leu Leu Ile Lys Gln Ala Thr Ser His Glu Asn Leu Cys Gln Cys Tyr 
1               5                   10                  15      
Ile Gly Trp Cys Pro Phe Trp 
            20              

<210> 570
<211> 23
<212> PRT
<213> Artificial Sequence


<220> 
<223> C-terminal degron targeted by the CRL4A and CRL4B complexes

<400> 570
Glu Ser Met Ala Tyr Met Pro Glu Gly Gly Cys Cys Asn Pro His Pro 
1               5                   10                  15      
Tyr Asn Glu Gly Tyr Val Tyr 
            20              

<210> 571
<211> 23
<212> PRT
<213> Artificial Sequence


<220> 
<223> C-terminal degron targeted by the CRL4A and CRL4B complexes

<400> 571
Gly Thr Pro Pro Thr Thr Leu Ala Arg Gly Lys Ala Arg Ser Ile Ser 
1               5                   10                  15      
Leu Lys Leu Asp Ser Glu Glu 
            20              

<210> 572
<211> 23
<212> PRT
<213> Artificial Sequence


<220> 
<223> C-terminal degron targeted by the CRL4A and CRL4B complexes

<400> 572
Val Lys Ala Val Ala Thr Ala Val Glu Gln Ile Tyr Pro Phe Val Phe 
1               5                   10                  15      
Glu Ser Arg Lys Glu Ile Leu 
            20              

<210> 573
<211> 23
<212> PRT
<213> Artificial Sequence


<220> 
<223> C-terminal degron targeted by the CRL4A and CRL4B complexes

<400> 573
Gln Leu Ser Leu Gln Cys Ser Lys Gly Arg Asp Gly Ile Ile Ala Asp 
1               5                   10                  15      
Ile Lys Met Val Gln Ile Gly 
            20              

<210> 574
<211> 23
<212> PRT
<213> Artificial Sequence


<220> 
<223> C-terminal degron targeted by the CRL4A and CRL4B complexes

<400> 574
Glu Lys His Phe Leu Pro Thr Pro Glu Glu Leu Gly Leu Leu Gly Pro 
1               5                   10                  15      
Pro Arg Pro Gln Val Leu Ala 
            20              

<210> 575
<211> 23
<212> PRT
<213> Artificial Sequence


<220> 
<223> C-terminal degron targeted by the CRL4A and CRL4B complexes

<400> 575
Phe Leu Gly Pro Lys Phe Lys Lys Leu Gln Asp Glu Gly Ser Ser Ser 
1               5                   10                  15      
Trp Lys Cys Lys Arg Asn Asn 
            20              

<210> 576
<211> 23
<212> PRT
<213> Artificial Sequence


<220> 
<223> C-terminal degron targeted by the CRL4A and CRL4B complexes

<400> 576
Leu Tyr Phe Val Phe Leu Ile Ile Ser Val Met Leu Glu Asp Arg Ile 
1               5                   10                  15      
Ile Ser Cys Pro Val Ser Val 
            20              

<210> 577
<211> 23
<212> PRT
<213> Artificial Sequence


<220> 
<223> C-terminal degron targeted by the CRL4A and CRL4B complexes

<400> 577
Cys Asn Ser His Lys Glu Lys Arg Met Asp Gly Arg Lys Ala Ser Gly 
1               5                   10                  15      
Glu Glu Gln Glu Cys Leu Asp 
            20              

<210> 578
<211> 23
<212> PRT
<213> Artificial Sequence


<220> 
<223> C-terminal degron targeted by the CRL4A and CRL4B complexes

<400> 578
Leu Lys Ala Gly Ala Ile Gly Cys Gly Gly Phe Ala Ala Phe Ser Ala 
1               5                   10                  15      
Ala Ile Asp Tyr Tyr Leu Arg 
            20              

<210> 579
<211> 23
<212> PRT
<213> Artificial Sequence


<220> 
<223> C-terminal degron targeted by the CRL4A and CRL4B complexes

<400> 579
Ala Met Lys Gly Arg Leu Ala Asn Gln Tyr Tyr Gln Lys Ala Glu Glu 
1               5                   10                  15      
Ala Trp Ala Gln Met Glu Glu 
            20              

<210> 580
<211> 23
<212> PRT
<213> Artificial Sequence


<220> 
<223> C-terminal degron targeted by the CRL4A and CRL4B complexes

<400> 580
Ala Met Gln Val Asn Gln Pro Leu Gln Thr Val Leu Asn Gln Leu Phe 
1               5                   10                  15      
Pro Gly Tyr Gly Asn Gly Arg 
            20              

<210> 581
<211> 23
<212> PRT
<213> Artificial Sequence


<220> 
<223> C-terminal degron targeted by the CRL4A and CRL4B complexes

<400> 581
Gly Leu Arg Val Thr Met His Gln Pro Val Leu Leu Cys Leu Leu Ala 
1               5                   10                  15      
Leu Ile Trp Leu Thr Val Lys 
            20              

<210> 582
<211> 23
<212> PRT
<213> Artificial Sequence


<220> 
<223> C-terminal degron targeted by the CRL4A and CRL4B complexes

<400> 582
Gly Pro Gly Pro Asn Gly Gln Arg Phe Cys Ile Asn Ser Val Ala Leu 
1               5                   10                  15      
Lys Phe Lys Pro Arg Lys His 
            20              

<210> 583
<211> 23
<212> PRT
<213> Artificial Sequence


<220> 
<223> C-terminal degron targeted by the CRL4A and CRL4B complexes

<400> 583
Ala Leu Asn Val Glu Pro Asp Gly Thr Gly Leu Thr Cys Ser Leu Ala 
1               5                   10                  15      
Pro Asn Ile Ile Ser Gln Leu 
            20              

<210> 584
<211> 23
<212> PRT
<213> Artificial Sequence


<220> 
<223> C-terminal degron targeted by the CRL4A and CRL4B complexes

<400> 584
Pro Gln Gly Ile Val Lys Leu Asp His Pro Arg Ile His Val Asp Phe 
1               5                   10                  15      
Pro Val Ile Leu Tyr Glu Val 
            20              

<210> 585
<211> 23
<212> PRT
<213> Artificial Sequence


<220> 
<223> C-terminal degron targeted by the CRL4A and CRL4B complexes

<400> 585
Lys Ala Met Glu Gly Ile Phe Met Lys Pro Ser Glu Leu Leu Lys Ala 
1               5                   10                  15      
Glu Ala His His Ala Glu Leu 
            20              

<210> 586
<211> 23
<212> PRT
<213> Artificial Sequence


<220> 
<223> C-terminal degron targeted by the CRL4A and CRL4B complexes

<400> 586
Ser Pro Asp Leu Ser Ala Gly Thr Ala Val Ser Ile Met Ile Gly Val 
1               5                   10                  15      
Leu Ala Gly Met Ala Leu Ile 
            20              

<210> 587
<211> 23
<212> PRT
<213> Artificial Sequence


<220> 
<223> C-terminal degron targeted by the CRL4A and CRL4B complexes

<400> 587
Lys His Ala Gln Pro Trp Asn Trp Cys Tyr Gln Ser Ser Val Gly Asn 
1               5                   10                  15      
Leu Tyr Ser Leu Glu Val Pro 
            20              

<210> 588
<211> 23
<212> PRT
<213> Artificial Sequence


<220> 
<223> C-terminal degron targeted by the CRL4A and CRL4B complexes

<400> 588
Pro Gly Lys Lys Gly Ser Asn Lys Arg Pro Gly Lys Arg Thr Arg Glu 
1               5                   10                  15      
Lys Met Lys Asn Arg Thr His 
            20              

<210> 589
<211> 23
<212> PRT
<213> Artificial Sequence


<220> 
<223> C-terminal degron targeted by the CRL4A and CRL4B complexes

<400> 589
Arg Cys Gln Leu Cys Pro Arg Ala Phe Ser Arg Ser Asp His Leu Ala 
1               5                   10                  15      
Leu His Met Lys Arg His Leu 
            20              

<210> 590
<211> 23
<212> PRT
<213> Artificial Sequence


<220> 
<223> C-terminal degron targeted by the CRL4A and CRL4B complexes

<400> 590
Pro Arg Lys Asn Gly Gly Trp Gly Asp Ile Arg Asp His Glu Leu Cys 
1               5                   10                  15      
Lys Ser Tyr Arg Arg Leu Gln 
            20              

<210> 591
<211> 23
<212> PRT
<213> Artificial Sequence


<220> 
<223> C-terminal degron targeted by the CRL4A and CRL4B complexes

<400> 591
Gly Tyr Thr Val Lys Lys His Leu Gln Asp Leu Ser Gly Arg Ile Ser 
1               5                   10                  15      
Arg Ala Arg His Asn Glu Leu 
            20              

<210> 592
<211> 23
<212> PRT
<213> Artificial Sequence


<220> 
<223> C-terminal degron targeted by the CRL4A and CRL4B complexes

<400> 592
Val Arg Ala Glu Ile Met Arg Ser Phe Ser Leu Ser Ala Asn Leu Gln 
1               5                   10                  15      
Glu Arg Leu Arg Arg Lys Glu 
            20              

<210> 593
<211> 23
<212> PRT
<213> Artificial Sequence


<220> 
<223> C-terminal degron targeted by the CRL4A and CRL4B complexes

<400> 593
Lys Gly Ala Cys His Gly Gln Thr Gly Met Phe Pro Arg Asn Tyr Val 
1               5                   10                  15      
Thr Pro Val Asn Arg Asn Val 
            20              

<210> 594
<211> 23
<212> PRT
<213> Artificial Sequence


<220> 
<223> C-terminal degron targeted by the CRL4A and CRL4B complexes

<400> 594
Ser Met Thr Asn Leu Val Arg Tyr Val Arg Gln Gly Leu Cys Trp Leu 
1               5                   10                  15      
Arg Ile Asp Ala His Leu Leu 
            20              

<210> 595
<211> 23
<212> PRT
<213> Artificial Sequence


<220> 
<223> C-terminal degron targeted by the CRL4A and CRL4B complexes

<400> 595
Met Ile Asn Asp Phe Gly Asp Gln Asn Gln Lys Phe Gly Phe Glu Val 
1               5                   10                  15      
Gly Pro Val Cys Phe Leu Gly 
            20              

<210> 596
<211> 23
<212> PRT
<213> Artificial Sequence


<220> 
<223> C-terminal degron targeted by the CRL4A and CRL4B complexes

<400> 596
Ser Pro Gly Leu Ser Ala Arg Ala Thr Val Ser Ile Met Ile Gly Val 
1               5                   10                  15      
Leu Ala Arg Val Ala Leu Ile 
            20              

<210> 597
<211> 23
<212> PRT
<213> Artificial Sequence


<220> 
<223> C-terminal degron targeted by the CRL4A and CRL4B complexes

<400> 597
Pro Ala Glu Trp Glu Lys Cys Leu Asn Leu Pro Leu Asp Val Gln Glu 
1               5                   10                  15      
Gly Asp Phe Gln Thr Glu Val 
            20              

<210> 598
<211> 23
<212> PRT
<213> Artificial Sequence


<220> 
<223> C-terminal degron targeted by the CRL4A and CRL4B complexes

<400> 598
Phe Gly Ser Asp Phe Glu Asn Tyr Ile Lys Thr Ile Ser Thr Thr Ile 
1               5                   10                  15      
Ser Pro Leu Leu Leu Ile Pro 
            20              

<210> 599
<211> 23
<212> PRT
<213> Artificial Sequence


<220> 
<223> C-terminal degron targeted by the CRL4A and CRL4B complexes

<400> 599
Glu Tyr Thr Leu Val Val Lys Trp Gly His Glu His Ile Pro Gly Ser 
1               5                   10                  15      
Pro Tyr Arg Val Val Val Pro 
            20              

<210> 600
<211> 23
<212> PRT
<213> Artificial Sequence


<220> 
<223> C-terminal degron targeted by the CRL4A and CRL4B complexes

<400> 600
Arg Asn Val Val Val Ala Cys Glu Asn Gly Leu Pro Val His Leu Asp 
1               5                   10                  15      
Gln Ser Ile Phe Arg Arg Pro 
            20              

<210> 601
<211> 23
<212> PRT
<213> Artificial Sequence


<220> 
<223> C-terminal degron targeted by the CRL4A and CRL4B complexes

<400> 601
Asn Arg Leu Glu Glu Thr Ala Arg Ala Leu Tyr Ser Leu Gly Ser Lys 
1               5                   10                  15      
Glu Asp Thr Val Ile Ser Leu 
            20              

<210> 602
<211> 23
<212> PRT
<213> Artificial Sequence


<220> 
<223> C-terminal degron targeted by the CRL4A and CRL4B complexes

<400> 602
Lys Ala Val Gly Asn Leu Arg Lys Cys Ser Thr Ser Ser Leu Leu Glu 
1               5                   10                  15      
Ala Cys Thr Phe Arg Arg Pro 
            20              

<210> 603
<211> 23
<212> PRT
<213> Artificial Sequence


<220> 
<223> C-terminal degron targeted by the CRL4A and CRL4B complexes

<400> 603
Arg Met Gly Glu Ser Asp Asp Ser Ile Leu Arg Leu Ala Lys Ala Asp 
1               5                   10                  15      
Gly Ile Val Ser Lys Asn Phe 
            20              

<210> 604
<211> 23
<212> PRT
<213> Artificial Sequence


<220> 
<223> C-terminal degron targeted by the CRL4A and CRL4B complexes

<400> 604
Phe Gly Ile His Asn Leu Phe Lys Phe Arg Ser Gln Gly Ser Cys Leu 
1               5                   10                  15      
Thr Lys Asp Ile Leu Glu Val 
            20              

<210> 605
<211> 23
<212> PRT
<213> Artificial Sequence


<220> 
<223> C-terminal degron targeted by the CRL4A and CRL4B complexes

<400> 605
Val Glu Glu Phe Gln Asn Leu Leu Thr Gln Val Lys Thr Leu Pro His 
1               5                   10                  15      
Ala Pro Leu Ala Ala Ala Pro 
            20              

<210> 606
<211> 23
<212> PRT
<213> Artificial Sequence


<220> 
<223> C-terminal degron targeted by the CRL4A and CRL4B complexes

<400> 606
Phe Val Val Ile Leu Val Thr Thr Gly Phe Val Phe Phe Gln Arg Ile 
1               5                   10                  15      
Asn His Val Arg Lys Val Leu 
            20              

<210> 607
<211> 23
<212> PRT
<213> Artificial Sequence


<220> 
<223> C-terminal degron targeted by the CRL4A and CRL4B complexes

<400> 607
Ile Val Tyr Cys Val Lys Thr Lys Gln Ile Arg Val Arg Val Val Ala 
1               5                   10                  15      
Lys Leu Cys Gln Arg Lys Ile 
            20              

<210> 608
<211> 23
<212> PRT
<213> Artificial Sequence


<220> 
<223> C-terminal degron targeted by the CRL4A and CRL4B complexes

<400> 608
Leu Ile Tyr Ser Leu Arg Asn Lys Glu Val Lys Ala Ala Val Gln Lys 
1               5                   10                  15      
Thr Leu Arg Gly Lys Leu Phe 
            20              

<210> 609
<211> 23
<212> PRT
<213> Artificial Sequence


<220> 
<223> C-terminal degron targeted by the CRL4A and CRL4B complexes

<400> 609
Leu Arg Asn Lys Asp Val Lys Gly Ala Leu Arg Lys Leu Val Gly Arg 
1               5                   10                  15      
Lys Cys Phe Ser His Arg Gln 
            20              

<210> 610
<211> 23
<212> PRT
<213> Artificial Sequence


<220> 
<223> C-terminal degron targeted by the CRL4A and CRL4B complexes

<400> 610
Gln Gly Val Asn Ser Gln Cys His Ser Ser Pro Ile Ser Ser Lys Cys 
1               5                   10                  15      
Glu Ser Arg Arg Arg Phe Pro 
            20              

<210> 611
<211> 23
<212> PRT
<213> Artificial Sequence


<220> 
<223> C-terminal degron targeted by the CRL4A and CRL4B complexes

<400> 611
Gln Leu Gln Gly Tyr Leu Arg Ser Val Phe Ala Leu Thr Asn Gly Ile 
1               5                   10                  15      
Tyr Pro His Lys Leu Val Phe 
            20              

<210> 612
<211> 23
<212> PRT
<213> Artificial Sequence


<220> 
<223> C-terminal degron targeted by the CRL4A and CRL4B complexes

<400> 612
Pro Tyr Ala Cys Lys Leu Leu Phe Gln Glu Leu Met Ser Met Ser Ile 
1               5                   10                  15      
Ala Pro Arg Met Met Ser Val 
            20              

<210> 613
<211> 23
<212> PRT
<213> Artificial Sequence


<220> 
<223> C-terminal degron targeted by the CRL4A and CRL4B complexes

<400> 613
Glu Ala Glu Gln Asn Glu Glu Asp Glu Pro Lys Gly Leu Gly Gly Ser 
1               5                   10                  15      
Arg Glu Ala Arg Gly Ser Val 
            20              

<210> 614
<211> 23
<212> PRT
<213> Artificial Sequence


<220> 
<223> C-terminal degron targeted by the CRL4A and CRL4B complexes

<400> 614
Pro Val Arg Pro Lys Thr Arg Thr Val Leu Val Pro Glu Arg Ser Ile 
1               5                   10                  15      
Asn Leu Gln Phe Leu Asp Arg 
            20              

<210> 615
<211> 23
<212> PRT
<213> Artificial Sequence


<220> 
<223> C-terminal degron targeted by the CRL4A and CRL4B complexes

<400> 615
Leu Phe Ile Ile Val Cys Phe Leu Gly Thr Ile Gly Leu Phe Leu Pro 
1               5                   10                  15      
Pro Phe Leu Ala Gly Met Ile 
            20              

<210> 616
<211> 23
<212> PRT
<213> Artificial Sequence


<220> 
<223> C-terminal degron targeted by the CRL4A and CRL4B complexes

<400> 616
Thr Ala Ala Met Ser Thr Tyr Thr Gly Ile Phe Thr Asp Gln Val Leu 
1               5                   10                  15      
Ser Val Leu Lys Gly Glu Glu 
            20              

<210> 617
<211> 23
<212> PRT
<213> Artificial Sequence


<220> 
<223> C-terminal degron targeted by the CRL4A and CRL4B complexes

<400> 617
Arg Asp Arg Cys Phe Val Ser Asn Arg Ala Cys Tyr Ser Ser Val Leu 
1               5                   10                  15      
Asn Ile Leu Tyr Thr Ser Cys 
            20              

<210> 618
<211> 23
<212> PRT
<213> Artificial Sequence


<220> 
<223> C-terminal degron targeted by the CRL4A and CRL4B complexes

<400> 618
Asn Gly Gly Gly Glu Val Asp Val Val Lys Cys Ser Leu Gly Gln Pro 
1               5                   10                  15      
His Ile Ala Tyr Phe Glu Glu 
            20              

<210> 619
<211> 23
<212> PRT
<213> Artificial Sequence


<220> 
<223> C-terminal degron targeted by the CRL4A and CRL4B complexes

<400> 619
Ala Cys Val Gln Val Phe Gly Met Ile Phe Thr Cys Cys Leu Tyr Arg 
1               5                   10                  15      
Ser Leu Lys Leu Glu His Tyr 
            20              

<210> 620
<211> 23
<212> PRT
<213> Artificial Sequence


<220> 
<223> C-terminal degron targeted by the CRL4A and CRL4B complexes

<400> 620
Ser Trp Thr Arg Val Phe Gln Ser Trp Trp Asp Arg Asn Leu Gly Arg 
1               5                   10                  15      
Gly Ser Ser Ala Pro Ser Gln 
            20              

<210> 621
<211> 23
<212> PRT
<213> Artificial Sequence


<220> 
<223> C-terminal degron targeted by the CRL4A and CRL4B complexes

<400> 621
Tyr Pro Gly Ile Arg Gln His Leu Ser Ser Val Val Phe Ile Lys Asn 
1               5                   10                  15      
Arg Leu Tyr Thr Asn Ser His 
            20              

<210> 622
<211> 23
<212> PRT
<213> Artificial Sequence


<220> 
<223> C-terminal degron targeted by the CRL4A and CRL4B complexes

<400> 622
Ala Leu His Ala Cys Cys Pro Ile Cys Arg Arg Pro Ile Lys Gly Ile 
1               5                   10                  15      
Ile Lys Thr Tyr Arg Ser Ser 
            20              

<210> 623
<211> 23
<212> PRT
<213> Artificial Sequence


<220> 
<223> C-terminal degron targeted by the CRL4A and CRL4B complexes

<400> 623
Gln Phe Val Ile Phe Asn Asn Thr Tyr Ile Tyr Ser Gly Met Ser Gln 
1               5                   10                  15      
Thr Ser Ala Thr Phe Gln Leu 
            20              

<210> 624
<211> 23
<212> PRT
<213> Artificial Sequence


<220> 
<223> C-terminal degron targeted by the CRL4A and CRL4B complexes

<400> 624
Ser Ala Lys Glu Lys Tyr Tyr Val Trp Leu Gln His Thr Leu Arg Lys 
1               5                   10                  15      
Lys Leu Ile Leu Ser Tyr Thr 
            20              

<210> 625
<211> 23
<212> PRT
<213> Artificial Sequence


<220> 
<223> C-terminal degron targeted by the CRL4A and CRL4B complexes

<400> 625
Lys Cys Asn His Cys Asp Arg Cys Phe Ser Arg Ser Asp His Leu Ala 
1               5                   10                  15      
Leu His Met Lys Arg His Ile 
            20              

<210> 626
<211> 23
<212> PRT
<213> Artificial Sequence


<220> 
<223> C-terminal degron targeted by the CRL4A and CRL4B complexes

<400> 626
Asn Asn Arg Gly Arg Arg Gln Lys Gln Asn Leu Gly His Phe Thr Ser 
1               5                   10                  15      
Asp Thr Ser Ser Arg Met Val 
            20              

<210> 627
<211> 23
<212> PRT
<213> Artificial Sequence


<220> 
<223> C-terminal degron targeted by the CRL4A and CRL4B complexes

<400> 627
Thr Val Thr Ala Met Asp Val Val Tyr Ala Leu Lys Arg Gln Gly Arg 
1               5                   10                  15      
Thr Leu Tyr Gly Phe Gly Gly 
            20              

<210> 628
<211> 23
<212> PRT
<213> Artificial Sequence


<220> 
<223> C-terminal degron targeted by the CRL4A and CRL4B complexes

<400> 628
Val Leu Ile Asn Arg Ser Leu Val Glu Arg Gly Leu Ala Gln Trp Val 
1               5                   10                  15      
Asp Ser Tyr Tyr Thr Ser Leu 
            20              

<210> 629
<211> 23
<212> PRT
<213> Artificial Sequence


<220> 
<223> C-terminal degron targeted by the CRL4A and CRL4B complexes

<400> 629
Lys Leu His Pro Ala Phe Gln Thr Pro Asn Ser Pro Gly Ser Gly Gly 
1               5                   10                  15      
Phe Pro Thr Gly Arg Leu Ala 
            20              

<210> 630
<211> 23
<212> PRT
<213> Artificial Sequence


<220> 
<223> C-terminal degron targeted by the CRL4A and CRL4B complexes

<400> 630
Thr Lys Tyr Phe Cys Ser Arg Ala Glu Arg Pro Arg Gly Gly Ala Ala 
1               5                   10                  15      
His Lys Pro Gly Arg Lys Pro 
            20              

<210> 631
<211> 23
<212> PRT
<213> Artificial Sequence


<220> 
<223> C-terminal degron targeted by the CRL4A and CRL4B complexes

<400> 631
Ser Ser Leu Gly Leu Leu Lys Val Trp Leu Pro Leu Leu Leu Ser Ala 
1               5                   10                  15      
Thr Leu Thr Leu Thr Phe Gln 
            20              

<210> 632
<211> 23
<212> PRT
<213> Artificial Sequence


<220> 
<223> C-terminal degron targeted by the CRL4A and CRL4B complexes

<400> 632
Ala Gly Cys Glu His Glu Leu Leu Lys Glu Lys Cys Lys Ala Thr Cys 
1               5                   10                  15      
Leu Cys Glu Asn Lys Ile Tyr 
            20              

<210> 633
<211> 23
<212> PRT
<213> Artificial Sequence


<220> 
<223> C-terminal degron targeted by the CRL4A and CRL4B complexes

<400> 633
Gln Lys Leu Leu Ser Leu Leu Glu Lys Asp Glu Phe Lys Ser Gly Ala 
1               5                   10                  15      
His Val Asp Phe Tyr Asp Lys 
            20              

<210> 634
<211> 23
<212> PRT
<213> Artificial Sequence


<220> 
<223> C-terminal degron targeted by the CRL4A and CRL4B complexes

<400> 634
Cys Pro Leu Lys Asn Pro Thr Phe Leu Asp Tyr Val Arg Pro Arg Ser 
1               5                   10                  15      
Trp Thr Cys Arg Tyr Val Phe 
            20              

<210> 635
<211> 23
<212> PRT
<213> Artificial Sequence


<220> 
<223> C-terminal degron targeted by the CRL4A and CRL4B complexes

<400> 635
Gln Ala Cys Pro Ile Thr Gly Tyr Pro Thr Glu Val Gln His Leu Ile 
1               5                   10                  15      
Lys Leu Tyr Ser Pro Glu Asn 
            20              

<210> 636
<211> 23
<212> PRT
<213> Artificial Sequence


<220> 
<223> C-terminal degron targeted by the CRL4A and CRL4B complexes

<400> 636
Ala Glu Ser Gln Val Asn Lys Leu Arg Ala Lys Ser Arg Asp Ile Gly 
1               5                   10                  15      
Thr Lys Gly Leu Asn Glu Glu 
            20              

<210> 637
<211> 23
<212> PRT
<213> Artificial Sequence


<220> 
<223> C-terminal degron targeted by the CRL4A and CRL4B complexes

<400> 637
Val Cys Ala Pro Asp Gly Val Leu Glu Glu Lys Leu Ser Pro Gln Cys 
1               5                   10                  15      
Gln Pro Leu His Asn Glu Leu 
            20              

<210> 638
<211> 23
<212> PRT
<213> Artificial Sequence


<220> 
<223> C-terminal degron targeted by the CRL4A and CRL4B complexes

<400> 638
Leu Ala Ser Glu Arg Ser Thr Val Asp Ala Glu Ala Val His Lys Leu 
1               5                   10                  15      
Leu Thr Leu Ile Lys Glu Leu 
            20              

<210> 639
<211> 23
<212> PRT
<213> Artificial Sequence


<220> 
<223> C-terminal degron targeted by the CRL4A and CRL4B complexes

<400> 639
Ser Ser Ala Pro Arg Val Thr Ser Gly Ser Thr Tyr Ile Leu Val Pro 
1               5                   10                  15      
Leu Ser His Leu Ala Gln Asn 
            20              

<210> 640
<211> 23
<212> PRT
<213> Artificial Sequence


<220> 
<223> C-terminal degron targeted by the CRL4A and CRL4B complexes

<400> 640
Val Gly Cys Val Ser Trp Val Glu Met Lys Lys Ala Ile Ser Asn Leu 
1               5                   10                  15      
Thr Asn Pro Pro Ala Pro Lys 
            20              

<210> 641
<211> 23
<212> PRT
<213> Artificial Sequence


<220> 
<223> C-terminal degron targeted by the CRL4A and CRL4B complexes

<400> 641
Ser Ser Glu Glu Gly Trp Arg Leu Phe Lys Ile Asp Lys Glu Tyr Leu 
1               5                   10                  15      
Leu Lys Met Ala Thr Glu Glu 
            20              

<210> 642
<211> 23
<212> PRT
<213> Artificial Sequence


<220> 
<223> C-terminal degron targeted by the CRL4A and CRL4B complexes

<400> 642
Leu Gly Ser Val Thr Phe Leu Ala Gly Asn Arg Met Leu Ala Gln Gln 
1               5                   10                  15      
Ala Val Lys Arg Thr Ala His 
            20              

<210> 643
<211> 23
<212> PRT
<213> Artificial Sequence


<220> 
<223> C-terminal degron targeted by the CRL4A and CRL4B complexes

<400> 643
Tyr Lys Phe Val Cys Glu Ala Ile Leu Arg Val Tyr Glu Glu Gly Leu 
1               5                   10                  15      
Val Gln Met Leu Asp Pro Ser 
            20              

<210> 644
<211> 23
<212> PRT
<213> Artificial Sequence


<220> 
<223> C-terminal degron targeted by the CRL4A and CRL4B complexes

<400> 644
Glu Phe Leu Pro Val Thr Pro Ile Leu Glu Gly Phe Val Ile Leu Arg 
1               5                   10                  15      
Lys Asn Pro Asn Tyr Asp Leu 
            20              

<210> 645
<211> 23
<212> PRT
<213> Artificial Sequence


<220> 
<223> C-terminal degron targeted by the CRL4A and CRL4B complexes

<400> 645
Glu Lys Pro Gly Val Tyr Thr Asn Val Cys Arg Tyr Thr Asn Trp Ile 
1               5                   10                  15      
Gln Lys Thr Ile Gln Ala Lys 
            20              

<210> 646
<211> 23
<212> PRT
<213> Artificial Sequence


<220> 
<223> C-terminal degron targeted by the CRL4A and CRL4B complexes

<400> 646
Cys Phe Gly Arg Lys Met Asp Arg Ile Ser Ser Ser Ser Gly Leu Gly 
1               5                   10                  15      
Cys Lys Val Leu Arg Arg His 
            20              

<210> 647
<211> 23
<212> PRT
<213> Artificial Sequence


<220> 
<223> C-terminal degron targeted by the CRL4A and CRL4B complexes

<400> 647
Val Asn Lys Leu Arg Ala Lys Thr Arg Asp Phe Thr Ser Ser Arg Met 
1               5                   10                  15      
Val Val His Glu Ser Glu Glu 
            20              

<210> 648
<211> 23
<212> PRT
<213> Artificial Sequence


<220> 
<223> C-terminal degron targeted by the CRL4A and CRL4B complexes

<400> 648
Phe Asp Pro Lys Thr Lys Arg Ile Leu Thr Leu Gln Lys Ala Asn Ser 
1               5                   10                  15      
Trp Phe Asn Cys Arg Lys Asn 
            20              

