               SEQUENCE LISTING

<110> Jiangyin USUN Pharmaceutical Co., Ltd.

<120> New conjugates of montelukast and peptides

<130> USUCZ/P70239PC

<140> PCT/CN2019/105832
<141> 2019-09-14

<150> PCT/CN2018/119072
<151> 2018-12-04

<150> PCT/CN2018/105703
<151> 2018-09-14

<160> 48

<170> BiSSAP 1.3.6

<210> 1
<211> 37
<212> PRT
<213> Hyalophora cecropia


<220> 
<221> MOD_RES
<222> 1
<223> Lysine residue with N-terminal hydrogen

<220> 
<223> Cecropin A

<220> 
<221> MOD_RES
<222> 37
<223> Lysine residue with C-terminal carboxamide

<400> 1
Xaa Trp Lys Leu Phe Lys Lys Ile Glu Lys Val Gly Gln Asn Ile Arg 
1               5                   10                  15      
Asp Gly Ile Ile Lys Ala Gly Pro Ala Val Ala Val Val Gly Gln Ala 
            20                  25                  30          
Thr Gln Ile Ala Xaa 
        35          

<210> 2
<211> 35
<212> PRT
<213> Hyalophora cecropia


<220> 
<221> MOD_RES
<222> 1
<223> Lysine residue with N-terminal hydrogen

<220> 
<223> Cecropin B

<220> 
<221> MOD_RES
<222> 35
<223> Lysine residue with C-terminal carboxamide

<400> 2
Xaa Trp Lys Val Phe Lys Lys Ile Glu Lys Met Gly Arg Asn Ile Arg 
1               5                   10                  15      
Asn Gly Ile Val Lys Ala Gly Pro Ala Ile Ala Val Leu Gly Glu Ala 
            20                  25                  30          
Lys Ala Xaa 
        35  

<210> 3
<211> 37
<212> PRT
<213> Homo sapiens


<220> 
<221> MOD_RES
<222> 1
<223> Lysine residue with N-terminal hydrogen

<220> 
<223> LL-37

<220> 
<221> MOD_RES
<222> 37
<223> Lysine residue with C-terminal carboxamide

<400> 3
Xaa Leu Gly Asp Phe Phe Arg Lys Ser Lys Glu Lys Ile Gly Lys Glu 
1               5                   10                  15      
Phe Lys Arg Ile Val Gln Arg Ile Lys Asp Phe Leu Arg Asn Leu Val 
            20                  25                  30          
Pro Arg Thr Glu Xaa 
        35          

<210> 4
<211> 10
<212> PRT
<213> Synthetic


<220> 
<221> SITE
<222> 6,7
<223> Wherein Xaa is 3- or 4-hydroxyproline

<220> 
<221> SITE
<222> 9
<223> Wherein Xaa is 3,4-dihydroxyphenylalanine

<400> 4
Ala Lys Pro Ser Tyr Xaa Xaa Thr Xaa Lys 
1               5                   10  

<210> 5
<211> 4
<212> PRT
<213> Synthetic


<220> 
<221> VARIANT
<222> 1
<223> Wherein Xaa represents a chain of 1 to 2 amino acid residues each
      independently selected from the group consisting of Ala and Lys

<220> 
<221> VARIANT
<222> 3
<223> Wherein Xaa is serine or phosphoserine

<220> 
<221> VARIANT
<222> 4
<223> Wherein Xaa represents a chain of 1 to 7 amino acid residues each
      independently selected from the group consisting of tyrosine,
      phosphotyrosine, 3-hydroxyproline, 4-hydroxyproline, threonine,
      phosphothreonine, 3,4-dihydroxyphenylalanine and lysine

<400> 5
Xaa Pro Xaa Xaa 
1               

<210> 6
<211> 6
<212> PRT
<213> Synthetic


<220> 
<221> SITE
<222> 4,5
<223> Wherein Xaa is 3- or 4-hydroxyproline

<400> 6
Ala Pro Ser Xaa Xaa Thr 
1               5       

<210> 7
<211> 8
<212> PRT
<213> Synthetic


<220> 
<221> VARIANT
<222> 1
<223> Wherein Xaa is absent or represents alanine

<220> 
<221> SITE
<222> 4
<223> Wherein Xaa is serine or phosphoserine

<220> 
<221> SITE
<222> 5
<223> Wherein Xaa is selected from the group consisting of
      3,4-dihydroxyphenylalanine, tyrosine and phosphotyrosine

<220> 
<221> SITE
<222> 6
<223> Wherein Xaa is 3- or 4-hydroxyproline

<220> 
<221> VARIANT
<222> 7
<223> Wherein Xaa represents a chain of 1 to 4 amino acid residues each
      independently selected from the group consisting of tyrosine,
      phosphotyrosine, 3-hydroxyproline, 4-hydroxyproline, threonine,
      phosphothreonine and 3,4-dihydroxyphenylalanine

<400> 7
Xaa Lys Pro Xaa Xaa Xaa Xaa Lys 
1               5               

<210> 8
<211> 7
<212> PRT
<213> Synthetic


<220> 
<221> SITE
<222> 3
<223> Wherein Xaa is serine or phosphoserine

<220> 
<221> SITE
<222> 4
<223> Wherein Xaa is selected from the group consisting of
      3,4-dihydroxyphenylalanine, tyrosine and phosphotyrosine

<220> 
<221> SITE
<222> 5
<223> Wherein Xaa is 3- or 4-hydroxyproline

<220> 
<221> VARIANT
<222> 6
<223> Wherein Xaa represents a chain of 1 to 4 amino acid residues each
      independently selected from the group consisting of tyrosine,
      phosphotyrosine, 3-hydroxyproline, 4-hydroxyproline, threonine,
      phosphothreonine and 3,4-dihydroxyphenylalanine

<400> 8
Lys Pro Xaa Xaa Xaa Xaa Lys 
1               5           

<210> 9
<211> 10
<212> PRT
<213> Synthetic


<220> 
<221> SITE
<222> 4
<223> Wherein Xaa is serine or phosphoserine

<220> 
<221> SITE
<222> 5
<223> Wherein Xaa is selected from the group consisting of
      3,4-dihydroxyphenylalanine, tyrosine and phosphotyrosine

<220> 
<221> SITE
<222> 6,7
<223> Wherein Xaa is 3- or 4-hydroxyproline

<220> 
<221> VARIANT
<222> 9
<223> Wherein Xaa is tyrosine, phosphotyrosine, 3-hydroxyproline,
      4-hydroxyproline, threonine, phosphothreonine or
      3,4-dihydroxyphenylalanine

<400> 9
Ala Lys Pro Xaa Xaa Xaa Xaa Thr Xaa Lys 
1               5                   10  

<210> 10
<211> 10
<212> PRT
<213> Synthetic


<220> 
<221> SITE
<222> 4
<223> Wherein Xaa is serine or phosphoserine

<220> 
<221> SITE
<222> 5
<223> Wherein Xaa is selected from the group consisting of
      3,4-dihydroxyphenylalanine, tyrosine and phosphotyrosine

<220> 
<221> SITE
<222> 6
<223> Wherein Xaa is 3- or 4-hydroxyproline

<220> 
<221> VARIANT
<222> 8
<223> Wherein Xaa is tyrosine, phosphotyrosine, 3-hydroxyproline,
      4-hydroxyproline, threonine, phosphothreonine or
      3,4-dihydroxyphenylalanine

<220> 
<221> SITE
<222> 9
<223> Wherein Xaa is 3- or 4-hydroxyproline

<400> 10
Ala Lys Pro Xaa Xaa Xaa Thr Xaa Xaa Lys 
1               5                   10  

<210> 11
<211> 10
<212> PRT
<213> Synthetic


<220> 
<221> SITE
<222> 4
<223> Wherein Xaa is phosphoserine

<220> 
<221> SITE
<222> 6,7
<223> Wherein Xaa is 3- or 4-hydroxyproline

<220> 
<221> SITE
<222> 9
<223> Wherein Xaa is 3,4-dihydroxyphenylalanine

<400> 11
Ala Lys Pro Xaa Tyr Xaa Xaa Thr Xaa Lys 
1               5                   10  

<210> 12
<211> 10
<212> PRT
<213> Synthetic


<220> 
<221> SITE
<222> 6,7
<223> Wherein Xaa is 3- or 4-hydroxyproline

<400> 12
Ala Lys Pro Ser Tyr Xaa Xaa Thr Tyr Lys 
1               5                   10  

<210> 13
<211> 10
<212> PRT
<213> Synthetic


<220> 
<221> SITE
<222> 4
<223> Wherein Xaa is phosphoserine

<220> 
<221> SITE
<222> 6,7
<223> Wherein Xaa is 3- or 4-hydroxyproline

<400> 13
Ala Lys Pro Xaa Tyr Xaa Xaa Thr Tyr Lys 
1               5                   10  

<210> 14
<211> 7
<212> PRT
<213> Synthetic


<220> 
<221> SITE
<222> 5
<223> Wherein Xaa is 3- or 4-hydroxyproline

<220> 
<221> SITE
<222> 6
<223> Wherein Xaa is 3,4-dihydroxyphenylalanine

<400> 14
Lys Pro Ser Tyr Xaa Xaa Lys 
1               5           

<210> 15
<211> 7
<212> PRT
<213> Synthetic


<220> 
<221> SITE
<222> 4
<223> Wherein Xaa is phosphotyrosine

<220> 
<221> SITE
<222> 5
<223> Wherein Xaa is 3- or 4-hydroxyproline

<220> 
<221> SITE
<222> 6
<223> Wherein Xaa is 3,4-dihydroxyphenylalanine

<400> 15
Lys Pro Ser Xaa Xaa Xaa Lys 
1               5           

<210> 16
<211> 10
<212> PRT
<213> Synthetic


<220> 
<221> SITE
<222> 6,7
<223> Wherein Xaa is 3- or 4-hydroxyproline

<220> 
<221> SITE
<222> 8
<223> Wherein Xaa is phosphothreonine

<220> 
<221> SITE
<222> 9
<223> Wherein Xaa is 3,4-dihydroxyphenylalanine

<400> 16
Ala Lys Pro Ser Tyr Xaa Xaa Xaa Xaa Lys 
1               5                   10  

<210> 17
<211> 10
<212> PRT
<213> Synthetic


<220> 
<221> SITE
<222> 6,7
<223> Wherein Xaa is 3- or 4-hydroxyproline

<220> 
<221> SITE
<222> 8
<223> Wherein Xaa is phosphothreonine

<400> 17
Ala Lys Pro Ser Tyr Xaa Xaa Xaa Tyr Lys 
1               5                   10  

<210> 18
<211> 11
<212> PRT
<213> Synthetic


<220> 
<221> SITE
<222> 6,7,10
<223> Wherein Xaa is 3- or 4-hydroxyproline

<220> 
<221> SITE
<222> 9
<223> Wherein Xaa is 3,4-dihydroxyphenylalanine

<400> 18
Ala Lys Pro Ser Tyr Xaa Xaa Thr Xaa Xaa Lys 
1               5                   10      

<210> 19
<211> 11
<212> PRT
<213> Synthetic


<220> 
<221> SITE
<222> 4
<223> Wherein Xaa is phosphoserine

<220> 
<221> SITE
<222> 6,7,10
<223> Wherein Xaa is 3- or 4-hydroxyproline

<220> 
<221> SITE
<222> 9
<223> Wherein Xaa is 3,4-dihydroxyphenylalanine

<400> 19
Ala Lys Pro Xaa Tyr Xaa Xaa Thr Xaa Xaa Lys 
1               5                   10      

<210> 20
<211> 11
<212> PRT
<213> Synthetic


<220> 
<221> SITE
<222> 6,7,10
<223> Wherein Xaa is 3- or 4-hydroxyproline

<400> 20
Ala Lys Pro Ser Tyr Xaa Xaa Thr Tyr Xaa Lys 
1               5                   10      

<210> 21
<211> 11
<212> PRT
<213> Synthetic


<220> 
<221> SITE
<222> 4
<223> Wherein Xaa is phosphoserine

<220> 
<221> SITE
<222> 6,7,10
<223> Wherein Xaa is 3- or 4-hydroxyproline

<400> 21
Ala Lys Pro Xaa Tyr Xaa Xaa Thr Tyr Xaa Lys 
1               5                   10      

<210> 22
<211> 10
<212> PRT
<213> Synthetic


<220> 
<221> SITE
<222> 6,9
<223> Wherein Xaa is 3- or 4-hydroxyproline

<220> 
<221> SITE
<222> 8
<223> Wherein Xaa is 3,4-dihydroxyphenylalanine

<400> 22
Ala Lys Pro Ser Tyr Xaa Thr Xaa Xaa Lys 
1               5                   10  

<210> 23
<211> 9
<212> PRT
<213> Synthetic


<220> 
<221> SITE
<222> 4
<223> Wherein Xaa is phosphoserine

<220> 
<221> SITE
<222> 6,9
<223> Wherein Xaa is 3- or 4-hydroxyproline

<220> 
<221> SITE
<222> 8
<223> Wherein Xaa is 3,4-dihydroxyphenylalanine

<400> 23
Ala Lys Pro Xaa Tyr Xaa Thr Xaa Lys 
1               5                   

<210> 24
<211> 10
<212> PRT
<213> Synthetic


<220> 
<221> SITE
<222> 6,9
<223> Wherein Xaa is 3- or 4-hydroxyproline

<400> 24
Ala Lys Pro Ser Tyr Xaa Thr Tyr Xaa Lys 
1               5                   10  

<210> 25
<211> 10
<212> PRT
<213> Synthetic


<220> 
<221> SITE
<222> 4
<223> Wherein Xaa is phosphoserine

<220> 
<221> SITE
<222> 6,9
<223> Wherein Xaa is 3- or 4-hydroxyproline

<400> 25
Ala Lys Pro Xaa Tyr Xaa Thr Tyr Xaa Lys 
1               5                   10  

<210> 26
<211> 11
<212> PRT
<213> Synthetic


<220> 
<221> SITE
<222> 6,7,10
<223> Wherein Xaa is 3- or 4-hydroxyproline

<220> 
<221> SITE
<222> 8
<223> Wherein Xaa is phosphothreonine

<220> 
<221> SITE
<222> 9
<223> Wherein Xaa is 3,4-dihydroxyphenylalanine

<400> 26
Ala Lys Pro Ser Tyr Xaa Xaa Xaa Xaa Xaa Lys 
1               5                   10      

<210> 27
<211> 11
<212> PRT
<213> Synthetic


<220> 
<221> SITE
<222> 6,7,10
<223> Wherein Xaa is 3- or 4-hydroxyproline

<220> 
<221> SITE
<222> 8
<223> Wherein Xaa is phosphothreonine

<400> 27
Ala Lys Pro Ser Tyr Xaa Xaa Xaa Tyr Xaa Lys 
1               5                   10      

<210> 28
<211> 9
<212> PRT
<213> Synthetic


<220> 
<221> SITE
<222> 6,7
<223> Wherein Xaa is 3- or 4-hydroxyproline

<220> 
<221> SITE
<222> 9
<223> Wherein Xaa is 3,4-dihydroxyphenylalanine

<400> 28
Ala Lys Pro Ser Tyr Xaa Xaa Thr Xaa 
1               5                   

<210> 29
<211> 9
<212> PRT
<213> Synthetic


<220> 
<221> SITE
<222> 4
<223> Wherein Xaa is phosphoserine

<220> 
<221> SITE
<222> 6,7
<223> Wherein Xaa is 3- or 4-hydroxyproline

<220> 
<221> SITE
<222> 9
<223> Wherein Xaa is 3,4-dihydroxyphenylalanine

<400> 29
Ala Lys Pro Xaa Tyr Xaa Xaa Thr Xaa 
1               5                   

<210> 30
<211> 9
<212> PRT
<213> Synthetic


<220> 
<221> SITE
<222> 6,7
<223> Wherein Xaa is 3- or 4-hydroxyproline

<400> 30
Ala Lys Pro Ser Tyr Xaa Xaa Thr Tyr 
1               5                   

<210> 31
<211> 9
<212> PRT
<213> Synthetic


<220> 
<221> SITE
<222> 4
<223> Wherein Xaa is phosphoserine

<220> 
<221> SITE
<222> 6,7
<223> Wherein Xaa is 3- or 4-hydroxyproline

<400> 31
Ala Lys Pro Xaa Tyr Xaa Xaa Thr Tyr 
1               5                   

<210> 32
<211> 6
<212> PRT
<213> Synthetic


<220> 
<221> SITE
<222> 5
<223> Wherein Xaa is 3- or 4-hydroxyproline

<220> 
<221> SITE
<222> 6
<223> Wherein Xaa is 3,4-dihydroxyphenylalanine

<400> 32
Lys Pro Ser Tyr Xaa Xaa 
1               5       

<210> 33
<211> 6
<212> PRT
<213> Synthetic


<220> 
<221> SITE
<222> 4
<223> Wherein Xaa is phosphotyrosine

<220> 
<221> SITE
<222> 5
<223> Wherein Xaa is 3- or 4-hydroxyproline

<220> 
<221> SITE
<222> 6
<223> Wherein Xaa is 3,4-dihydroxyphenylalanine

<400> 33
Lys Pro Ser Xaa Xaa Xaa 
1               5       

<210> 34
<211> 9
<212> PRT
<213> Synthetic


<220> 
<221> SITE
<222> 6,7
<223> Wherein Xaa is 3- or 4-hydroxyproline

<220> 
<221> SITE
<222> 8
<223> Wherein Xaa is phosphothreonine

<220> 
<221> SITE
<222> 9
<223> Wherein Xaa is 3,4-dihydroxyphenylalanine

<400> 34
Ala Lys Pro Ser Tyr Xaa Xaa Xaa Xaa 
1               5                   

<210> 35
<211> 9
<212> PRT
<213> Synthetic


<220> 
<221> SITE
<222> 6,7
<223> Wherein Xaa is 3- or 4-hydroxyproline

<220> 
<221> SITE
<222> 8
<223> Wherein Xaa is phosphothreonine

<400> 35
Ala Lys Pro Ser Tyr Xaa Xaa Xaa Tyr 
1               5                   

<210> 36
<211> 10
<212> PRT
<213> Synthetic


<220> 
<221> SITE
<222> 6,7,10
<223> Wherein Xaa is 3- or 4-hydroxyproline

<220> 
<221> SITE
<222> 9
<223> Wherein Xaa is 3,4-dihydroxyphenylalanine

<400> 36
Ala Lys Pro Ser Tyr Xaa Xaa Thr Xaa Xaa 
1               5                   10  

<210> 37
<211> 10
<212> PRT
<213> Synthetic


<220> 
<221> SITE
<222> 4
<223> Wherein Xaa is phosphoserine

<220> 
<221> SITE
<222> 6,7,10
<223> Wherein Xaa is 3- or 4-hydroxyproline

<220> 
<221> SITE
<222> 9
<223> Wherein Xaa is 3,4-dihydroxyphenylalanine

<400> 37
Ala Lys Pro Xaa Tyr Xaa Xaa Thr Xaa Xaa 
1               5                   10  

<210> 38
<211> 10
<212> PRT
<213> Synthetic


<220> 
<221> SITE
<222> 6,7,10
<223> Wherein Xaa is 3- or 4-hydroxyproline

<400> 38
Ala Lys Pro Ser Tyr Xaa Xaa Thr Tyr Xaa 
1               5                   10  

<210> 39
<211> 10
<212> PRT
<213> Synthetic


<220> 
<221> SITE
<222> 4
<223> Wherein Xaa is phosphoserine

<220> 
<221> SITE
<222> 6,7,10
<223> Wherein Xaa is 3- or 4-hydroxyproline

<400> 39
Ala Lys Pro Xaa Tyr Xaa Xaa Thr Tyr Xaa 
1               5                   10  

<210> 40
<211> 9
<212> PRT
<213> Synthetic


<220> 
<221> SITE
<222> 6,9
<223> Wherein Xaa is 3- or 4-hydroxyproline

<220> 
<221> SITE
<222> 8
<223> Wherein Xaa is 3,4-dihydroxyphenylalanine

<400> 40
Ala Lys Pro Ser Tyr Xaa Thr Xaa Xaa 
1               5                   

<210> 41
<211> 9
<212> PRT
<213> Synthetic


<220> 
<221> SITE
<222> 4
<223> Wherein Xaa is phosphoserine

<220> 
<221> SITE
<222> 6,9
<223> Wherein Xaa is 3- or 4-hydroxyproline

<220> 
<221> SITE
<222> 8
<223> Wherein Xaa is 3,4-dihydroxyphenylalanine

<400> 41
Ala Lys Pro Xaa Tyr Xaa Thr Xaa Xaa 
1               5                   

<210> 42
<211> 9
<212> PRT
<213> Synthetic


<220> 
<221> SITE
<222> 6,9
<223> Wherein Xaa is 3- or 4-hydroxyproline

<400> 42
Ala Lys Pro Ser Tyr Xaa Thr Tyr Xaa 
1               5                   

<210> 43
<211> 9
<212> PRT
<213> Synthetic


<220> 
<221> SITE
<222> 4
<223> Wherein Xaa is phosphoserine

<220> 
<221> SITE
<222> 6,9
<223> Wherein Xaa is 3- or 4-hydroxyproline

<400> 43
Ala Lys Pro Xaa Tyr Xaa Thr Tyr Xaa 
1               5                   

<210> 44
<211> 10
<212> PRT
<213> Synthetic


<220> 
<221> SITE
<222> 6,7,10
<223> Wherein Xaa is 3- or 4-hydroxyproline

<220> 
<221> SITE
<222> 8
<223> Wherein Xaa is phosphothreonine

<220> 
<221> SITE
<222> 9
<223> Wherein Xaa is 3,4-dihydroxyphenylalanine

<400> 44
Ala Lys Pro Ser Tyr Xaa Xaa Xaa Xaa Xaa 
1               5                   10  

<210> 45
<211> 10
<212> PRT
<213> Synthetic


<220> 
<221> SITE
<222> 6,7,10
<223> Wherein Xaa is 3- or 4-hydroxyproline

<220> 
<221> SITE
<222> 8
<223> Wherein Xaa is phosphothreonine

<400> 45
Ala Lys Pro Ser Tyr Xaa Xaa Xaa Tyr Xaa 
1               5                   10  

<210> 46
<211> 7
<212> PRT
<213> Synthetic


<220> 
<221> SITE
<222> 6,7
<223> Wherein Xaa is 3- or 4-hydroxyproline

<400> 46
Ala Lys Pro Ser Tyr Xaa Xaa 
1               5           

<210> 47
<211> 6
<212> PRT
<213> Synthetic


<220> 
<221> SITE
<222> 6
<223> Wherein Xaa is 3- or 4-hydroxyproline

<400> 47
Ala Lys Pro Ser Tyr Xaa 
1               5       

<210> 48
<211> 4
<212> PRT
<213> Synthetic


<220> 
<221> SITE
<222> 1,4
<223> Wherein Xaa is 3- or 4-hydroxyproline

<400> 48
Xaa Thr Tyr Xaa 
1               

