                         SEQUENCE LISTING

<110>  Universiteit Gent
 
<120>  Compositions for use to treat advanced glycation end products-dependent ocular diseases
<130>  P2018/084 PCT

<160>  4     

<170>  PatentIn version 3.5

<210>  1
<211>  325
<212>  PRT
<213>  Homo sapiens

<400>  1

Met His His His His His His Val Asn Gly Pro Gly Ser Asp Glu Val 
1               5                   10                  15      


Asp Glu Gln Leu Leu Arg Ala Glu Leu Arg Thr Ala Thr Leu Arg Ala 
            20                  25                  30          


Phe Gly Gly Pro Gly Ala Gly Cys Ile Ser Glu Gly Arg Ala Tyr Asp 
        35                  40                  45              


Thr Asp Ala Gly Pro Val Phe Val Lys Val Asn Arg Arg Thr Gln Ala 
    50                  55                  60                  


Arg Gln Met Phe Glu Gly Glu Val Ala Ser Leu Glu Ala Leu Arg Ser 
65                  70                  75                  80  


Thr Gly Leu Val Arg Val Pro Arg Pro Met Lys Val Ile Asp Leu Pro 
                85                  90                  95      


Gly Gly Gly Ala Ala Phe Val Met Glu His Leu Lys Met Lys Ser Leu 
            100                 105                 110         


Ser Ser Gln Ala Ser Lys Leu Gly Glu Gln Met Ala Asp Leu His Leu 
        115                 120                 125             


Tyr Asn Gln Lys Leu Arg Glu Lys Leu Lys Glu Glu Glu Asn Thr Val 
    130                 135                 140                 


Gly Arg Arg Gly Glu Gly Ala Glu Pro Gln Tyr Val Asp Lys Phe Gly 
145                 150                 155                 160 


Phe His Thr Val Thr Cys Cys Gly Phe Ile Pro Gln Val Asn Glu Trp 
                165                 170                 175     


Gln Asp Asp Trp Pro Thr Phe Phe Ala Arg His Arg Leu Gln Ala Gln 
            180                 185                 190         


Leu Asp Leu Ile Glu Lys Asp Tyr Ala Asp Arg Glu Ala Arg Glu Leu 
        195                 200                 205             


Trp Ser Arg Leu Gln Val Lys Ile Pro Asp Leu Phe Cys Gly Leu Glu 
    210                 215                 220                 


Ile Val Pro Ala Leu Leu His Gly Asp Leu Trp Ser Gly Asn Val Ala 
225                 230                 235                 240 


Glu Asp Asp Val Gly Pro Ile Ile Tyr Asp Pro Ala Ser Phe Tyr Gly 
                245                 250                 255     


His Ser Glu Phe Glu Leu Ala Ile Ala Leu Met Phe Gly Gly Phe Pro 
            260                 265                 270         


Arg Ser Phe Phe Thr Ala Tyr His Arg Lys Ile Pro Lys Ala Pro Gly 
        275                 280                 285             


Phe Asp Gln Arg Leu Leu Leu Tyr Gln Leu Phe Asn Tyr Leu Asn His 
    290                 295                 300                 


Trp Asn His Phe Gly Arg Glu Tyr Arg Ser Pro Ser Leu Gly Thr Met 
305                 310                 315                 320 


Arg Arg Leu Leu Lys 
                325 


<210>  2
<211>  308
<212>  PRT
<213>  Homo sapiens

<400>  2

Glu Gln Leu Leu Arg Ala Glu Leu Arg Thr Ala Thr Leu Arg Ala Phe 
1               5                   10                  15      


Gly Gly Pro Gly Ala Gly Cys Ile Ser Glu Gly Arg Ala Tyr Asp Thr 
            20                  25                  30          


Asp Ala Gly Pro Val Phe Val Lys Val Asn Arg Arg Thr Gln Ala Arg 
        35                  40                  45              


Gln Met Phe Glu Gly Glu Val Ala Ser Leu Glu Ala Leu Arg Ser Thr 
    50                  55                  60                  


Gly Leu Val Arg Val Pro Arg Pro Met Lys Val Ile Asp Leu Pro Gly 
65                  70                  75                  80  


Gly Gly Ala Ala Phe Val Met Glu His Leu Lys Met Lys Ser Leu Ser 
                85                  90                  95      


Ser Gln Ala Ser Lys Leu Gly Glu Gln Met Ala Asp Leu His Leu Tyr 
            100                 105                 110         


Asn Gln Lys Leu Arg Glu Lys Leu Lys Glu Glu Glu Asn Thr Val Gly 
        115                 120                 125             


Arg Arg Gly Glu Gly Ala Glu Pro Gln Tyr Val Asp Lys Phe Gly Phe 
    130                 135                 140                 


His Thr Val Thr Cys Cys Gly Phe Ile Pro Gln Val Asn Glu Trp Gln 
145                 150                 155                 160 


Asp Asp Trp Pro Thr Phe Phe Ala Arg His Arg Leu Gln Ala Gln Leu 
                165                 170                 175     


Asp Leu Ile Glu Lys Asp Tyr Ala Asp Arg Glu Ala Arg Glu Leu Trp 
            180                 185                 190         


Ser Arg Leu Gln Val Lys Ile Pro Asp Leu Phe Cys Gly Leu Glu Ile 
        195                 200                 205             


Val Pro Ala Leu Leu His Gly Asp Leu Trp Ser Gly Asn Val Ala Glu 
    210                 215                 220                 


Asp Asp Val Gly Pro Ile Ile Tyr Asp Pro Ala Ser Phe Tyr Gly His 
225                 230                 235                 240 


Ser Glu Phe Glu Leu Ala Ile Ala Leu Met Phe Gly Gly Phe Pro Arg 
                245                 250                 255     


Ser Phe Phe Thr Ala Tyr His Arg Lys Ile Pro Lys Ala Pro Gly Phe 
            260                 265                 270         


Asp Gln Arg Leu Leu Leu Tyr Gln Leu Phe Asn Tyr Leu Asn His Trp 
        275                 280                 285             


Asn His Phe Gly Arg Glu Tyr Arg Ser Pro Ser Leu Gly Thr Met Arg 
    290                 295                 300                 


Arg Leu Leu Lys 
305             


<210>  3
<211>  978
<212>  DNA
<213>  Homo sapiens

<400>  3
atgcatcatc atcatcatca tgttaacggt ccaggttctg atgaagttga tgaacagttg       60

ttgagagctg agttgagaac tgctactttg agagcttttg gtggtccagg tgctggttgt      120

atttctgagg gtagagctta cgatactgac gctggtccag ttttcgttaa ggttaacaga      180

agaactcagg ctagacagat gttcgagggt gaagttgctt ctttggaggc tttgagatcc      240

actggtttgg ttagagttcc aagaccaatg aaggttatcg acttgccagg tggtggtgct      300

gcttttgtta tggaacactt gaagatgaag tccttgtcct cccaggcttc taagttgggt      360

gaacaaatgg ctgacttgca cttgtacaac cagaagttga gagaaaagtt gaaagaggaa      420

gagaacactg ttggtagaag aggtgaaggt gctgagccac aatacgttga caagttcggt      480

ttccacactg ttacttgttg tggtttcatc ccacaggtta acgagtggca agatgactgg      540

ccaactttct tcgctagaca cagattgcaa gctcagttgg acttgatcga gaaggactac      600

gctgacagag aagctagaga attgtggtcc agattgcagg ttaagatccc agacttgttc      660

tgtggtttgg agatcgttcc agctttgttg cacggtgatt tgtggtctgg taacgttgct      720

gaagatgacg ttggtccaat tatctacgac ccagcttctt tctacggtca ctctgaattc      780

gagttggcta tcgctttgat gttcggtggt ttcccaagat ccttcttcac tgcttaccac      840

agaaagatcc caaaggctcc aggtttcgac cagagattgt tgttgtacca gttgttcaac      900

tacttgaacc attggaacca cttcggtaga gagtacagat ctccatcctt gggtactatg      960

agaagattgt tgaagtaa                                                    978


<210>  4
<211>  927
<212>  DNA
<213>  Homo sapiens

<400>  4
gaacagttgt tgagagctga gttgagaact gctactttga gagcttttgg tggtccaggt       60

gctggttgta tttctgaggg tagagcttac gatactgacg ctggtccagt tttcgttaag      120

gttaacagaa gaactcaggc tagacagatg ttcgagggtg aagttgcttc tttggaggct      180

ttgagatcca ctggtttggt tagagttcca agaccaatga aggttatcga cttgccaggt      240

ggtggtgctg cttttgttat ggaacacttg aagatgaagt ccttgtcctc ccaggcttct      300

aagttgggtg aacaaatggc tgacttgcac ttgtacaacc agaagttgag agaaaagttg      360

aaagaggaag agaacactgt tggtagaaga ggtgaaggtg ctgagccaca atacgttgac      420

aagttcggtt tccacactgt tacttgttgt ggtttcatcc cacaggttaa cgagtggcaa      480

gatgactggc caactttctt cgctagacac agattgcaag ctcagttgga cttgatcgag      540

aaggactacg ctgacagaga agctagagaa ttgtggtcca gattgcaggt taagatccca      600

gacttgttct gtggtttgga gatcgttcca gctttgttgc acggtgattt gtggtctggt      660

aacgttgctg aagatgacgt tggtccaatt atctacgacc cagcttcttt ctacggtcac      720

tctgaattcg agttggctat cgctttgatg ttcggtggtt tcccaagatc cttcttcact      780

gcttaccaca gaaagatccc aaaggctcca ggtttcgacc agagattgtt gttgtaccag      840

ttgttcaact acttgaacca ttggaaccac ttcggtagag agtacagatc tccatccttg      900

ggtactatga gaagattgtt gaagtaa                                          927


