                               SEQUENCE LISTING

<110> AFFINIVAX, INC.
 
<120> MULTIVALENT PNEUMOCOCCAL VACCINES

<130> 2011588-0068

<140> PCT/US2019/050907
<141> 2019-09-12

<150> 62/730,471
<151> 2018-09-12

<160> 14    

<170> PatentIn version 3.5

<210> 1
<211> 179
<212> PRT
<213> Unknown

<220>
<223> Description of Unknown: 
      Rhizavidin protein sequence

<400> 1
Met Ile Ile Thr Ser Leu Tyr Ala Thr Phe Gly Thr Ile Ala Asp Gly 
1               5                   10                  15      


Arg Arg Thr Ser Gly Gly Lys Thr Met Ile Arg Thr Asn Ala Val Ala 
            20                  25                  30          


Ala Leu Val Phe Ala Val Ala Thr Ser Ala Leu Ala Phe Asp Ala Ser 
        35                  40                  45              


Asn Phe Lys Asp Phe Ser Ser Ile Ala Ser Ala Ser Ser Ser Trp Gln 
    50                  55                  60                  


Asn Gln Ser Gly Ser Thr Met Ile Ile Gln Val Asp Ser Phe Gly Asn 
65                  70                  75                  80  


Val Ser Gly Gln Tyr Val Asn Arg Ala Gln Gly Thr Gly Cys Gln Asn 
                85                  90                  95      


Ser Pro Tyr Pro Leu Thr Gly Arg Val Asn Gly Thr Phe Ile Ala Phe 
            100                 105                 110         


Ser Val Gly Trp Asn Asn Ser Thr Glu Asn Cys Asn Ser Ala Thr Gly 
        115                 120                 125             


Trp Thr Gly Tyr Ala Gln Val Asn Gly Asn Asn Thr Glu Ile Val Thr 
    130                 135                 140                 


Ser Trp Asn Leu Ala Tyr Glu Gly Gly Ser Gly Pro Ala Ile Glu Gln 
145                 150                 155                 160 


Gly Gln Asp Thr Phe Gln Tyr Val Pro Thr Thr Glu Asn Lys Ser Leu 
                165                 170                 175     


Leu Lys Asp 
            


<210> 2
<211> 135
<212> PRT
<213> Unknown

<220>
<223> Description of Unknown: 
      Rhizavidin protein sequence

<400> 2
Phe Asp Ala Ser Asn Phe Lys Asp Phe Ser Ser Ile Ala Ser Ala Ser 
1               5                   10                  15      


Ser Ser Trp Gln Asn Gln Ser Gly Ser Thr Met Ile Ile Gln Val Asp 
            20                  25                  30          


Ser Phe Gly Asn Val Ser Gly Gln Tyr Val Asn Arg Ala Gln Gly Thr 
        35                  40                  45              


Gly Cys Gln Asn Ser Pro Tyr Pro Leu Thr Gly Arg Val Asn Gly Thr 
    50                  55                  60                  


Phe Ile Ala Phe Ser Val Gly Trp Asn Asn Ser Thr Glu Asn Cys Asn 
65                  70                  75                  80  


Ser Ala Thr Gly Trp Thr Gly Tyr Ala Gln Val Asn Gly Asn Asn Thr 
                85                  90                  95      


Glu Ile Val Thr Ser Trp Asn Leu Ala Tyr Glu Gly Gly Ser Gly Pro 
            100                 105                 110         


Ala Ile Glu Gln Gly Gln Asp Thr Phe Gln Tyr Val Pro Thr Thr Glu 
        115                 120                 125             


Asn Lys Ser Leu Leu Lys Asp 
    130                 135 


<210> 3
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 3
Gly Gly Gly Gly Ser Ser Ser 
1               5           


<210> 4
<211> 367
<212> PRT
<213> Streptococcus pneumoniae

<400> 4
Phe Arg Gln Pro Ser Gln Thr Ala Leu Lys Asp Glu Pro Thr His Leu 
1               5                   10                  15      


Val Val Ala Lys Glu Gly Ser Val Ala Ser Ser Val Leu Leu Ser Gly 
            20                  25                  30          


Thr Val Thr Ala Lys Asn Glu Gln Tyr Val Tyr Phe Asp Ala Ser Lys 
        35                  40                  45              


Gly Asp Leu Asp Glu Ile Leu Val Ser Val Gly Asp Lys Val Ser Glu 
    50                  55                  60                  


Gly Gln Ala Leu Val Lys Tyr Ser Ser Ser Glu Ala Gln Ala Ala Tyr 
65                  70                  75                  80  


Asp Ser Ala Ser Arg Ala Val Ala Arg Ala Asp Arg His Ile Asn Glu 
                85                  90                  95      


Leu Asn Gln Ala Arg Asn Glu Ala Ala Ser Ala Pro Ala Pro Gln Leu 
            100                 105                 110         


Pro Ala Pro Val Gly Gly Glu Asp Ala Thr Val Gln Ser Pro Thr Pro 
        115                 120                 125             


Val Ala Gly Asn Ser Val Ala Ser Ile Asp Ala Gln Leu Gly Asp Ala 
    130                 135                 140                 


Arg Asp Ala Arg Ala Asp Ala Ala Ala Gln Leu Ser Lys Ala Gln Ser 
145                 150                 155                 160 


Gln Leu Asp Ala Thr Thr Val Leu Ser Thr Leu Glu Gly Thr Val Val 
                165                 170                 175     


Glu Val Asn Ser Asn Val Ser Lys Ser Pro Thr Gly Ala Ser Gln Val 
            180                 185                 190         


Met Val His Ile Val Ser Asn Glu Asn Leu Gln Val Lys Gly Glu Leu 
        195                 200                 205             


Ser Glu Tyr Asn Leu Ala Asn Leu Ser Val Gly Gln Glu Val Ser Phe 
    210                 215                 220                 


Thr Ser Lys Val Tyr Pro Asp Lys Lys Trp Thr Gly Lys Leu Ser Tyr 
225                 230                 235                 240 


Ile Ser Asp Tyr Pro Lys Asn Asn Gly Glu Ala Ala Ser Pro Ala Ala 
                245                 250                 255     


Gly Asn Asn Thr Gly Ser Lys Tyr Pro Tyr Thr Ile Asp Val Thr Gly 
            260                 265                 270         


Glu Val Gly Asp Leu Lys Gln Gly Phe Ser Val Asn Ile Glu Val Lys 
        275                 280                 285             


Ser Lys Thr Lys Ala Ile Leu Val Pro Val Ser Ser Leu Val Met Asp 
    290                 295                 300                 


Asp Ser Lys Asn Tyr Val Trp Ile Val Asp Glu Gln Gln Lys Ala Lys 
305                 310                 315                 320 


Lys Val Glu Val Ser Leu Gly Asn Ala Asp Ala Glu Asn Gln Glu Ile 
                325                 330                 335     


Thr Ser Gly Leu Thr Asn Gly Ala Lys Val Ile Ser Asn Pro Thr Ser 
            340                 345                 350         


Ser Leu Glu Glu Gly Lys Glu Val Lys Ala Asp Glu Ala Thr Asn 
        355                 360                 365         


<210> 5
<211> 252
<212> PRT
<213> Streptococcus pneumoniae

<400> 5
Thr Ser Gly Asp Asn Trp Ser Lys Tyr Gln Ser Asn Lys Ser Ile Thr 
1               5                   10                  15      


Ile Gly Phe Asp Ser Thr Phe Val Pro Met Gly Phe Ala Gln Lys Asp 
            20                  25                  30          


Gly Ser Tyr Ala Gly Phe Asp Ile Asp Leu Ala Thr Ala Val Phe Glu 
        35                  40                  45              


Lys Tyr Gly Ile Thr Val Asn Trp Gln Pro Ile Asp Trp Asp Leu Lys 
    50                  55                  60                  


Glu Ala Glu Leu Thr Lys Gly Thr Ile Asp Leu Ile Trp Asn Gly Tyr 
65                  70                  75                  80  


Ser Ala Thr Asp Glu Arg Arg Glu Lys Val Ala Phe Ser Asn Ser Tyr 
                85                  90                  95      


Met Lys Asn Glu Gln Val Leu Val Thr Lys Lys Ser Ser Gly Ile Thr 
            100                 105                 110         


Thr Ala Lys Asp Met Thr Gly Lys Thr Leu Gly Ala Gln Ala Gly Ser 
        115                 120                 125             


Ser Gly Tyr Ala Asp Phe Glu Ala Asn Pro Glu Ile Leu Lys Asn Ile 
    130                 135                 140                 


Val Ala Asn Lys Glu Ala Asn Gln Tyr Gln Thr Phe Asn Glu Ala Leu 
145                 150                 155                 160 


Ile Asp Leu Lys Asn Asp Arg Ile Asp Gly Leu Leu Ile Asp Arg Val 
                165                 170                 175     


Tyr Ala Asn Tyr Tyr Leu Glu Ala Glu Gly Val Leu Asn Asp Tyr Asn 
            180                 185                 190         


Val Phe Thr Val Gly Leu Glu Thr Glu Ala Phe Ala Val Gly Ala Arg 
        195                 200                 205             


Lys Glu Asp Thr Asn Leu Val Lys Lys Ile Asn Glu Ala Phe Ser Ser 
    210                 215                 220                 


Leu Tyr Lys Asp Gly Lys Phe Gln Glu Ile Ser Gln Lys Trp Phe Gly 
225                 230                 235                 240 


Glu Asp Val Ala Thr Lys Glu Val Lys Glu Gly Gln 
                245                 250         


<210> 6
<211> 765
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 6
Met Phe Asp Ala Ser Asn Phe Lys Asp Phe Ser Ser Ile Ala Ser Ala 
1               5                   10                  15      


Ser Ser Ser Trp Gln Asn Gln Ser Gly Ser Thr Met Ile Ile Gln Val 
            20                  25                  30          


Asp Ser Phe Gly Asn Val Ser Gly Gln Tyr Val Asn Arg Ala Gln Gly 
        35                  40                  45              


Thr Gly Cys Gln Asn Ser Pro Tyr Pro Leu Thr Gly Arg Val Asn Gly 
    50                  55                  60                  


Thr Phe Ile Ala Phe Ser Val Gly Trp Asn Asn Ser Thr Glu Asn Cys 
65                  70                  75                  80  


Asn Ser Ala Thr Gly Trp Thr Gly Tyr Ala Gln Val Asn Gly Asn Asn 
                85                  90                  95      


Thr Glu Ile Val Thr Ser Trp Asn Leu Ala Tyr Glu Gly Gly Ser Gly 
            100                 105                 110         


Pro Ala Ile Glu Gln Gly Gln Asp Thr Phe Gln Tyr Val Pro Thr Thr 
        115                 120                 125             


Glu Asn Lys Ser Leu Leu Lys Asp Gly Gly Gly Gly Ser Ser Ser Thr 
    130                 135                 140                 


Ser Gly Asp Asn Trp Ser Lys Tyr Gln Ser Asn Lys Ser Ile Thr Ile 
145                 150                 155                 160 


Gly Phe Asp Ser Thr Phe Val Pro Met Gly Phe Ala Gln Lys Asp Gly 
                165                 170                 175     


Ser Tyr Ala Gly Phe Asp Ile Asp Leu Ala Thr Ala Val Phe Glu Lys 
            180                 185                 190         


Tyr Gly Ile Thr Val Asn Trp Gln Pro Ile Asp Trp Asp Leu Lys Glu 
        195                 200                 205             


Ala Glu Leu Thr Lys Gly Thr Ile Asp Leu Ile Trp Asn Gly Tyr Ser 
    210                 215                 220                 


Ala Thr Asp Glu Arg Arg Glu Lys Val Ala Phe Ser Asn Ser Tyr Met 
225                 230                 235                 240 


Lys Asn Glu Gln Val Leu Val Thr Lys Lys Ser Ser Gly Ile Thr Thr 
                245                 250                 255     


Ala Lys Asp Met Thr Gly Lys Thr Leu Gly Ala Gln Ala Gly Ser Ser 
            260                 265                 270         


Gly Tyr Ala Asp Phe Glu Ala Asn Pro Glu Ile Leu Lys Asn Ile Val 
        275                 280                 285             


Ala Asn Lys Glu Ala Asn Gln Tyr Gln Thr Phe Asn Glu Ala Leu Ile 
    290                 295                 300                 


Asp Leu Lys Asn Asp Arg Ile Asp Gly Leu Leu Ile Asp Arg Val Tyr 
305                 310                 315                 320 


Ala Asn Tyr Tyr Leu Glu Ala Glu Gly Val Leu Asn Asp Tyr Asn Val 
                325                 330                 335     


Phe Thr Val Gly Leu Glu Thr Glu Ala Phe Ala Val Gly Ala Arg Lys 
            340                 345                 350         


Glu Asp Thr Asn Leu Val Lys Lys Ile Asn Glu Ala Phe Ser Ser Leu 
        355                 360                 365             


Tyr Lys Asp Gly Lys Phe Gln Glu Ile Ser Gln Lys Trp Phe Gly Glu 
    370                 375                 380                 


Asp Val Ala Thr Lys Glu Val Lys Glu Gly Gln Ala Ala Ala Phe Arg 
385                 390                 395                 400 


Gln Pro Ser Gln Thr Ala Leu Lys Asp Glu Pro Thr His Leu Val Val 
                405                 410                 415     


Ala Lys Glu Gly Ser Val Ala Ser Ser Val Leu Leu Ser Gly Thr Val 
            420                 425                 430         


Thr Ala Lys Asn Glu Gln Tyr Val Tyr Phe Asp Ala Ser Lys Gly Asp 
        435                 440                 445             


Leu Asp Glu Ile Leu Val Ser Val Gly Asp Lys Val Ser Glu Gly Gln 
    450                 455                 460                 


Ala Leu Val Lys Tyr Ser Ser Ser Glu Ala Gln Ala Ala Tyr Asp Ser 
465                 470                 475                 480 


Ala Ser Arg Ala Val Ala Arg Ala Asp Arg His Ile Asn Glu Leu Asn 
                485                 490                 495     


Gln Ala Arg Asn Glu Ala Ala Ser Ala Pro Ala Pro Gln Leu Pro Ala 
            500                 505                 510         


Pro Val Gly Gly Glu Asp Ala Thr Val Gln Ser Pro Thr Pro Val Ala 
        515                 520                 525             


Gly Asn Ser Val Ala Ser Ile Asp Ala Gln Leu Gly Asp Ala Arg Asp 
    530                 535                 540                 


Ala Arg Ala Asp Ala Ala Ala Gln Leu Ser Lys Ala Gln Ser Gln Leu 
545                 550                 555                 560 


Asp Ala Thr Thr Val Leu Ser Thr Leu Glu Gly Thr Val Val Glu Val 
                565                 570                 575     


Asn Ser Asn Val Ser Lys Ser Pro Thr Gly Ala Ser Gln Val Met Val 
            580                 585                 590         


His Ile Val Ser Asn Glu Asn Leu Gln Val Lys Gly Glu Leu Ser Glu 
        595                 600                 605             


Tyr Asn Leu Ala Asn Leu Ser Val Gly Gln Glu Val Ser Phe Thr Ser 
    610                 615                 620                 


Lys Val Tyr Pro Asp Lys Lys Trp Thr Gly Lys Leu Ser Tyr Ile Ser 
625                 630                 635                 640 


Asp Tyr Pro Lys Asn Asn Gly Glu Ala Ala Ser Pro Ala Ala Gly Asn 
                645                 650                 655     


Asn Thr Gly Ser Lys Tyr Pro Tyr Thr Ile Asp Val Thr Gly Glu Val 
            660                 665                 670         


Gly Asp Leu Lys Gln Gly Phe Ser Val Asn Ile Glu Val Lys Ser Lys 
        675                 680                 685             


Thr Lys Ala Ile Leu Val Pro Val Ser Ser Leu Val Met Asp Asp Ser 
    690                 695                 700                 


Lys Asn Tyr Val Trp Ile Val Asp Glu Gln Gln Lys Ala Lys Lys Val 
705                 710                 715                 720 


Glu Val Ser Leu Gly Asn Ala Asp Ala Glu Asn Gln Glu Ile Thr Ser 
                725                 730                 735     


Gly Leu Thr Asn Gly Ala Lys Val Ile Ser Asn Pro Thr Ser Ser Leu 
            740                 745                 750         


Glu Glu Gly Lys Glu Val Lys Ala Asp Glu Ala Thr Asn 
        755                 760                 765 


<210> 7
<211> 1101
<212> DNA
<213> Streptococcus pneumoniae

<400> 7
tttagacaac cttctcagac tgctctaaaa gatgagccta ctcatcttgt tgttgccaag       60

gaaggaagcg tggcctcctc tgttttattg tcagggacag taacagcaaa aaatgaacaa      120

tatgtttatt ttgatgctag taagggtgat ttagatgaaa tccttgtttc tgtgggcgat      180

aaggtcagcg aagggcaggc tttagtcaag tacagtagtt cagaagcgca ggcggcctat      240

gattcagcta gtcgagcagt agctagggca gatcgtcata tcaatgaact caatcaagca      300

cgaaatgaag ccgcttcagc tccggctcca cagttaccag cgccagtagg aggagaagat      360

gcaacggtgc aaagcccaac tccagtggct ggaaattctg ttgcttctat tgacgctcaa      420

ttgggtgatg cccgtgatgc gcgtgcagat gctgcggcgc aattaagcaa ggctcaaagt      480

caattggatg caacaactgt tctcagtacc ctagagggaa ctgtggtcga agtcaatagc      540

aatgtttcta aatctccaac aggggcgagt caagttatgg ttcatattgt cagcaatgaa      600

aatttacaag tcaagggaga attgtctgag tacaatctag ccaacctttc tgtaggtcaa      660

gaagtaagct ttacttctaa agtgtatcct gataaaaaat ggactgggaa attaagctat      720

atttctgact atcctaaaaa caatggtgaa gcagctagtc cagcagccgg gaataataca      780

ggttctaaat acccttatac tattgatgtg acaggcgagg ttggtgattt gaaacaaggt      840

ttttctgtca acattgaggt taaaagcaaa actaaggcta ttcttgttcc tgttagcagt      900

ctagtaatgg atgatagtaa aaattatgtc tggattgtgg atgaacaaca aaaggctaaa      960

aaagttgagg tttcattggg aaatgctgac gcagaaaatc aagaaatcac ttctggttta     1020

acgaacggtg ctaaggtcat cagtaatcca acatcttcct tggaagaagg aaaagaggtg     1080

aaggctgatg aagcaactaa t                                               1101


<210> 8
<211> 756
<212> DNA
<213> Streptococcus pneumoniae

<400> 8
actagtggag ataattggtc aaagtaccag tctaacaagt ctattactat tggatttgat       60

agtacttttg ttccaatggg atttgctcag aaagatggtt cttatgcagg atttgatatt      120

gatttagcta cagctgtttt tgaaaaatac ggaatcacgg taaattggca accgattgat      180

tgggatttga aagaagctga attgacaaaa ggaacgattg atctgatttg gaatggctat      240

tccgctacag acgaacgccg tgaaaaggtg gctttcagta actcatatat gaagaatgag      300

caggtattgg ttacgaagaa atcatctggt atcacgactg caaaggatat gactggaaag      360

acattaggag ctcaagctgg ttcatctggt tatgcggact ttgaagcaaa tccagaaatt      420

ttgaagaata ttgtcgctaa taaggaagcg aatcaatacc aaacctttaa tgaagccttg      480

attgatttga aaaacgatcg aattgatggt ctattgattg accgtgtcta tgcaaactat      540

tatttagaag cagaaggtgt tttaaacgat tataatgtct ttacagttgg actagaaaca      600

gaagcttttg cggttggagc ccgtaaggaa gatacaaact tggttaagaa gataaatgaa      660

gctttttcta gtctttacaa ggacggcaag ttccaagaaa tcagccaaaa atggtttgga      720

gaagatgtag caaccaaaga agtaaaagaa ggacag                                756


<210> 9
<211> 2295
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 9
atgttcgacg catccaactt taaagacttt agcagcatcg cgtccgcaag ctctagctgg       60

cagaatcaat ctggtagcac catgattatc caagtggaca gctttggtaa cgtcagcggt      120

caatatgtta atcgtgcaca gggtacgggt tgtcagaatt ctccgtaccc gctgaccggt      180

cgtgttaacg gcacgttcat cgctttcagc gtcggttgga acaattctac tgaaaattgc      240

aacagcgcga ccggttggac gggctatgca caagtgaatg gcaataacac cgaaatcgtc      300

acgtcctgga atctggcgta tgagggtggc agcggtccgg ctattgaaca gggccaggat      360

accttccaat acgtccctac gaccgagaat aagtcccttc tgaaagacgg cggtggcggt      420

tcgagctcga ccagcggcga caattggtcc aaataccaga gcaacaagag catcacgatc      480

ggcttcgaca gcacttttgt gccgatgggt ttcgcgcaaa aagacggtag ctacgcgggt      540

ttcgatattg acctggcgac cgctgtcttt gagaaatacg gcattacggt taattggcag      600

ccgattgatt gggacctgaa agaggccgaa ctcaccaaag gcaccatcga cctgatctgg      660

aatggttact ccgcaaccga tgagcgtcgc gaaaaagttg ccttcagcaa cagctatatg      720

aagaatgaac aagtgttggt aaccaagaaa tctagcggca ttacgaccgc gaaagacatg      780

accggtaaga cgctgggtgc gcaggccggt agctctggct atgcggattt cgaggcgaat      840

cctgagattc tgaaaaacat cgttgcgaat aaagaggcga accagtacca gacctttaac      900

gaagcactga tcgacctgaa aaacgatcgc attgacggtc tgctgatcga tcgtgtgtac      960

gcgaactatt atctggaagc cgagggcgtt ctgaacgatt ataatgtttt taccgtgggt     1020

ctggagactg aggcattcgc ggttggtgcg cgcaaggaag ataccaacct ggttaaaaag     1080

attaatgagg catttagctc actgtacaag gacggcaagt tccaagaaat tagccagaag     1140

tggttcggtg aagatgttgc gacgaaagag gttaaagagg gccaagcggc cgcatttcgc     1200

caaccgagcc agactgcgtt gaaagatgag ccgacccatc tggttgttgc gaaagagggc     1260

agcgtggcat cgagcgtgct gctgagcggt acggttactg ccaaaaacga acaatacgtg     1320

tacttcgatg ctagcaaggg tgatctggat gaaattctgg tgagcgtggg tgacaaagtt     1380

agcgaaggcc aggcactggt gaagtattca tcctccgagg cacaggcagc gtacgacagc     1440

gcaagccgcg cagtggcgcg tgccgaccgt cacattaacg aattgaacca agcgcgtaac     1500

gaggccgcaa gcgcgccagc accgcagctg ccggctccgg tgggtggcga agatgcgacg     1560

gtgcagagcc cgaccccggt tgcgggtaat tcggtcgcca gcatcgatgc gcagctgggt     1620

gacgcgcgtg atgcccgtgc ggatgcggct gctcaactga gcaaggctca gagccaactg     1680

gacgcgacga cggtgctgag caccttggag ggtaccgttg tcgaagtcaa cagcaatgtg     1740

agcaagagcc caacgggtgc gagccaggtt atggtccaca ttgtgagcaa tgaaaactta     1800

caggtcaagg gtgagctgag cgagtataac ctggcgaatc tgagcgttgg tcaagaggtc     1860

agctttacca gcaaggtcta cccggataag aaatggaccg gcaagttgag ctacatcagc     1920

gactacccga agaacaatgg cgaggcagcc tccccggcag ccggcaacaa taccggctct     1980

aagtatccgt acaccatcga cgtaaccggt gaggtcggcg acctgaaaca gggttttagc     2040

gtgaatatcg aagtgaagtc caagaccaag gcaattttgg ttccggttag ctccctggtg     2100

atggacgata gcaagaatta tgtgtggatt gtcgacgagc aacagaaagc gaaaaaagtt     2160

gaagtgagcc tgggcaatgc tgatgccgag aaccaagaaa tcacgtctgg tctgaccaac     2220

ggtgcgaaag ttattagcaa cccgaccagc agcctggaag agggtaaaga ggtcaaagcc     2280

gacgaagcta cgaac                                                      2295


<210> 10
<211> 399
<212> PRT
<213> Streptococcus pneumoniae

<400> 10
Met Lys Lys Lys Asn Gly Lys Ala Lys Lys Trp Gln Leu Tyr Ala Ala 
1               5                   10                  15      


Ile Gly Ala Ala Ser Val Val Val Leu Gly Ala Gly Gly Ile Leu Leu 
            20                  25                  30          


Phe Arg Gln Pro Ser Gln Thr Ala Leu Lys Asp Glu Pro Thr His Leu 
        35                  40                  45              


Val Val Ala Lys Glu Gly Ser Val Ala Ser Ser Val Leu Leu Ser Gly 
    50                  55                  60                  


Thr Val Thr Ala Lys Asn Glu Gln Tyr Val Tyr Phe Asp Ala Ser Lys 
65                  70                  75                  80  


Gly Asp Leu Asp Glu Ile Leu Val Ser Val Gly Asp Lys Val Ser Glu 
                85                  90                  95      


Gly Gln Ala Leu Val Lys Tyr Ser Ser Ser Glu Ala Gln Ala Ala Tyr 
            100                 105                 110         


Asp Ser Ala Ser Arg Ala Val Ala Arg Ala Asp Arg His Ile Asn Glu 
        115                 120                 125             


Leu Asn Gln Ala Arg Asn Glu Ala Ala Ser Ala Pro Ala Pro Gln Leu 
    130                 135                 140                 


Pro Ala Pro Val Gly Gly Glu Asp Ala Thr Val Gln Ser Pro Thr Pro 
145                 150                 155                 160 


Val Ala Gly Asn Ser Val Ala Ser Ile Asp Ala Gln Leu Gly Asp Ala 
                165                 170                 175     


Arg Asp Ala Arg Ala Asp Ala Ala Ala Gln Leu Ser Lys Ala Gln Ser 
            180                 185                 190         


Gln Leu Asp Ala Thr Thr Val Leu Ser Thr Leu Glu Gly Thr Val Val 
        195                 200                 205             


Glu Val Asn Ser Asn Val Ser Lys Ser Pro Thr Gly Ala Ser Gln Val 
    210                 215                 220                 


Met Val His Ile Val Ser Asn Glu Asn Leu Gln Val Lys Gly Glu Leu 
225                 230                 235                 240 


Ser Glu Tyr Asn Leu Ala Asn Leu Ser Val Gly Gln Glu Val Ser Phe 
                245                 250                 255     


Thr Ser Lys Val Tyr Pro Asp Lys Lys Trp Thr Gly Lys Leu Ser Tyr 
            260                 265                 270         


Ile Ser Asp Tyr Pro Lys Asn Asn Gly Glu Ala Ala Ser Pro Ala Ala 
        275                 280                 285             


Gly Asn Asn Thr Gly Ser Lys Tyr Pro Tyr Thr Ile Asp Val Thr Gly 
    290                 295                 300                 


Glu Val Gly Asp Leu Lys Gln Gly Phe Ser Val Asn Ile Glu Val Lys 
305                 310                 315                 320 


Ser Lys Thr Lys Ala Ile Leu Val Pro Val Ser Ser Leu Val Met Asp 
                325                 330                 335     


Asp Ser Lys Asn Tyr Val Trp Ile Val Asp Glu Gln Gln Lys Ala Lys 
            340                 345                 350         


Lys Val Glu Val Ser Leu Gly Asn Ala Asp Ala Glu Asn Gln Glu Ile 
        355                 360                 365             


Thr Ser Gly Leu Thr Asn Gly Ala Lys Val Ile Ser Asn Pro Thr Ser 
    370                 375                 380                 


Ser Leu Glu Glu Gly Lys Glu Val Lys Ala Asp Glu Ala Thr Asn 
385                 390                 395                 


<210> 11
<211> 1197
<212> DNA
<213> Streptococcus pneumoniae

<400> 11
atgaagaaaa agaatggtaa agctaaaaag tggcaactgt atgcagcaat cggtgctgcg       60

agtgtagttg tattgggtgc tggggggatt ttactcttta gacaaccttc tcagactgct      120

ctaaaagatg agcctactca tcttgttgtt gccaaggaag gaagcgtggc ctcctctgtt      180

ttattgtcag ggacagtaac agcaaaaaat gaacaatatg tttattttga tgctagtaag      240

ggtgatttag atgaaatcct tgtttctgtg ggcgataagg tcagcgaagg gcaggcttta      300

gtcaagtaca gtagttcaga agcgcaggcg gcctatgatt cagctagtcg agcagtagct      360

agggcagatc gtcatatcaa tgaactcaat caagcacgaa atgaagccgc ttcagctccg      420

gctccacagt taccagcgcc agtaggagga gaagatgcaa cggtgcaaag cccaactcca      480

gtggctggaa attctgttgc ttctattgac gctcaattgg gtgatgcccg tgatgcgcgt      540

gcagatgctg cggcgcaatt aagcaaggct caaagtcaat tggatgcaac aactgttctc      600

agtaccctag agggaactgt ggtcgaagtc aatagcaatg tttctaaatc tccaacaggg      660

gcgagtcaag ttatggttca tattgtcagc aatgaaaatt tacaagtcaa gggagaattg      720

tctgagtaca atctagccaa cctttctgta ggtcaagaag taagctttac ttctaaagtg      780

tatcctgata aaaaatggac tgggaaatta agctatattt ctgactatcc taaaaacaat      840

ggtgaagcag ctagtccagc agccgggaat aatacaggtt ctaaataccc ttatactatt      900

gatgtgacag gcgaggttgg tgatttgaaa caaggttttt ctgtcaacat tgaggttaaa      960

agcaaaacta aggctattct tgttcctgtt agcagtctag taatggatga tagtaaaaat     1020

tatgtctgga ttgtggatga acaacaaaag gctaaaaaag ttgaggtttc attgggaaat     1080

gctgacgcag aaaatcaaga aatcacttct ggtttaacga acggtgctaa ggtcatcagt     1140

aatccaacat cttccttgga agaaggaaaa gaggtgaagg ctgatgaagc aactaat        1197


<210> 12
<211> 278
<212> PRT
<213> Streptococcus pneumoniae

<400> 12
Met Lys Lys Trp Met Leu Val Leu Val Ser Leu Met Thr Ala Leu Phe 
1               5                   10                  15      


Leu Val Ala Cys Gly Lys Asn Ser Ser Glu Thr Ser Gly Asp Asn Trp 
            20                  25                  30          


Ser Lys Tyr Gln Ser Asn Lys Ser Ile Thr Ile Gly Phe Asp Ser Thr 
        35                  40                  45              


Phe Val Pro Met Gly Phe Ala Gln Lys Asp Gly Ser Tyr Ala Gly Phe 
    50                  55                  60                  


Asp Ile Asp Leu Ala Thr Ala Val Phe Glu Lys Tyr Gly Ile Thr Val 
65                  70                  75                  80  


Asn Trp Gln Pro Ile Asp Trp Asp Leu Lys Glu Ala Glu Leu Thr Lys 
                85                  90                  95      


Gly Thr Ile Asp Leu Ile Trp Asn Gly Tyr Ser Ala Thr Asp Glu Arg 
            100                 105                 110         


Arg Glu Lys Val Ala Phe Ser Asn Ser Tyr Met Lys Asn Glu Gln Val 
        115                 120                 125             


Leu Val Thr Lys Lys Ser Ser Gly Ile Thr Thr Ala Lys Asp Met Thr 
    130                 135                 140                 


Gly Lys Thr Leu Gly Ala Gln Ala Gly Ser Ser Gly Tyr Ala Asp Phe 
145                 150                 155                 160 


Glu Ala Asn Pro Glu Ile Leu Lys Asn Ile Val Ala Asn Lys Glu Ala 
                165                 170                 175     


Asn Gln Tyr Gln Thr Phe Asn Glu Ala Leu Ile Asp Leu Lys Asn Asp 
            180                 185                 190         


Arg Ile Asp Gly Leu Leu Ile Asp Arg Val Tyr Ala Asn Tyr Tyr Leu 
        195                 200                 205             


Glu Ala Glu Gly Val Leu Asn Asp Tyr Asn Val Phe Thr Val Gly Leu 
    210                 215                 220                 


Glu Thr Glu Ala Phe Ala Val Gly Ala Arg Lys Glu Asp Thr Asn Leu 
225                 230                 235                 240 


Val Lys Lys Ile Asn Glu Ala Phe Ser Ser Leu Tyr Lys Asp Gly Lys 
                245                 250                 255     


Phe Gln Glu Ile Ser Gln Lys Trp Phe Gly Glu Asp Val Ala Thr Lys 
            260                 265                 270         


Glu Val Lys Glu Gly Gln 
        275             


<210> 13
<211> 834
<212> DNA
<213> Streptococcus pneumoniae

<400> 13
atgaaaaaat ggatgcttgt attagtcagt ctgatgactg ctttgttctt agtagcttgt       60

gggaaaaatt ctagcgaaac tagtggagat aattggtcaa agtaccagtc taacaagtct      120

attactattg gatttgatag tacttttgtt ccaatgggat ttgctcagaa agatggttct      180

tatgcaggat ttgatattga tttagctaca gctgtttttg aaaaatacgg aatcacggta      240

aattggcaac cgattgattg ggatttgaaa gaagctgaat tgacaaaagg aacgattgat      300

ctgatttgga atggctattc cgctacagac gaacgccgtg aaaaggtggc tttcagtaac      360

tcatatatga agaatgagca ggtattggtt acgaagaaat catctggtat cacgactgca      420

aaggatatga ctggaaagac attaggagct caagctggtt catctggtta tgcggacttt      480

gaagcaaatc cagaaatttt gaagaatatt gtcgctaata aggaagcgaa tcaataccaa      540

acctttaatg aagccttgat tgatttgaaa aacgatcgaa ttgatggtct attgattgac      600

cgtgtctatg caaactatta tttagaagca gaaggtgttt taaacgatta taatgtcttt      660

acagttggac tagaaacaga agcttttgcg gttggagccc gtaaggaaga tacaaacttg      720

gttaagaaga taaatgaagc tttttctagt ctttacaagg acggcaagtt ccaagaaatc      780

agccaaaaat ggtttggaga agatgtagca accaaagaag taaaagaagg acag            834


<210> 14
<211> 4
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 14
Gly Gly Gly Gly 
1               


