               SEQUENCE LISTING

<110> INSERM
      UNIVERSITE DE NANTES
      CENTRE HOSPITALIER UNIVERSITAIRE DE NANTES
      GUILLONNEAU Carole
      ANEGON Ignacio

<120> ANTI-HUMAN CD45RC ANTIBODIES AND USES THEREOF

<130> CV - 1093/PCT

<150> EP18306230.6
<151> 2018-09-21

<160> 129

<170> BiSSAP 1.3.6

<210> 1
<211> 5
<212> PRT
<213> Artificial Sequence


<220> 
<223> VH-CDR1

<400> 1
Asn Tyr Tyr Ile Gly 
1               5   

<210> 2
<211> 17
<212> PRT
<213> Artificial Sequence


<220> 
<221> SITE
<222> 1
<223> Xaa is selected from Asp (D), Ile (I) and Arg (R)

<220> 
<223> VH-CDR2

<220> 
<221> SITE
<222> 4
<223> Xaa is selected from Pro and Ser (S)

<220> 
<221> SITE
<222> 7
<223> Xaa is selected from Asp (D), Ser (S) and Gly (G)

<220> 
<221> SITE
<222> 9
<223> Xaa is selected from Ala (A) and Thr (T)

<220> 
<221> SITE
<222> 11
<223> Xaa is selected from Ser (S) and Tyr (Y)

<220> 
<221> SITE
<222> 12
<223> Xaa is selected from Asn (N), Ala (A) and Ser (S)

<220> 
<221> SITE
<222> 13
<223> Xaa is selected from Glu (E), Asp (D), Pro (P) and Gln (Q)

<220> 
<221> SITE
<222> 14
<223> Xaa is selected from Lys (K) and Ser (S)

<220> 
<221> SITE
<222> 15
<223> Xaa is selected from Phe (F) and Val (V)

<220> 
<221> SITE
<222> 16
<223> Xaa is selected from Lys (K) and Gln (Q)

<400> 2
Xaa Ile Phe Xaa Gly Gly Xaa Tyr Xaa Asn Xaa Xaa Xaa Xaa Xaa Xaa 
1               5                   10                  15      
Gly 
    

<210> 3
<211> 5
<212> PRT
<213> Artificial Sequence


<220> 
<223> VH-CDR3

<400> 3
Arg Asn Phe Asp Tyr 
1               5   

<210> 4
<211> 17
<212> PRT
<213> Artificial Sequence


<220> 
<223> VH-CDR2

<400> 4
Asp Ile Phe Pro Gly Gly Asp Tyr Ala Asn Ser Asn Glu Lys Phe Lys 
1               5                   10                  15      
Gly 
    

<210> 5
<211> 17
<212> PRT
<213> Artificial Sequence


<220> 
<223> VH-CDR2

<400> 5
Asp Ile Phe Pro Gly Gly Asp Tyr Ala Asn Ser Asn Glu Lys Val Lys 
1               5                   10                  15      
Gly 
    

<210> 6
<211> 17
<212> PRT
<213> Artificial Sequence


<220> 
<223> VH-CDR2

<400> 6
Asp Ile Phe Pro Gly Gly Gly Tyr Thr Asn Tyr Ala Glu Lys Phe Gln 
1               5                   10                  15      
Gly 
    

<210> 7
<211> 17
<212> PRT
<213> Artificial Sequence


<220> 
<223> VH-CDR2

<400> 7
Asp Ile Phe Pro Gly Gly Ser Tyr Thr Asn Tyr Ser Glu Ser Phe Gln 
1               5                   10                  15      
Gly 
    

<210> 8
<211> 17
<212> PRT
<213> Artificial Sequence


<220> 
<223> VH-CDR2

<400> 8
Asp Ile Phe Pro Gly Gly Ser Tyr Thr Asn Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      
Gly 
    

<210> 9
<211> 17
<212> PRT
<213> Artificial Sequence


<220> 
<223> VH-CDR2

<400> 9
Arg Ile Phe Pro Gly Gly Gly Tyr Thr Asn Tyr Ala Gln Lys Phe Gln 
1               5                   10                  15      
Gly 
    

<210> 10
<211> 17
<212> PRT
<213> Artificial Sequence


<220> 
<223> VH-CDR2

<400> 10
Ile Ile Phe Pro Gly Gly Ser Tyr Thr Asn Tyr Ser Pro Ser Phe Gln 
1               5                   10                  15      
Gly 
    

<210> 11
<211> 17
<212> PRT
<213> Artificial Sequence


<220> 
<223> VH-CDR2

<400> 11
Asp Ile Phe Ser Gly Gly Ser Tyr Thr Asn Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      
Gly 
    

<210> 12
<211> 11
<212> PRT
<213> Artificial Sequence


<220> 
<221> SITE
<222> 1
<223> Xaa is selected from Ser (S) and Arg (R)

<220> 
<223> VL-CDR1

<220> 
<221> SITE
<222> 8
<223> Xaa is absent, or is selected from Asn (N), Ser (S) and Gly (G)

<400> 12
Xaa Ala Ser Ser Ser Val Ser Xaa Tyr Met His 
1               5                   10      

<210> 13
<211> 7
<212> PRT
<213> Artificial Sequence


<220> 
<221> SITE
<222> 1
<223> Xaa is selected from Asn (N) and Ala (A); or Xaa is any amino
      acid but Ala (A) or Asn (N)

<220> 
<223> VL-CDR2

<220> 
<221> SITE
<222> 5
<223> Xaa is selected from Leu (L), Ser (S) and Arg (R)

<220> 
<221> SITE
<222> 6
<223> Xaa is selected from Pro (P), Ala (A) and Gln (Q)

<220> 
<221> SITE
<222> 7
<223> Xaa is selected from Ser (S) and Thr (T)

<400> 13
Xaa Thr Ser Asn Xaa Xaa Xaa 
1               5           

<210> 14
<211> 10
<212> PRT
<213> Artificial Sequence


<220> 
<221> SITE
<222> 1
<223> Xaa is selected from Gln (Q) and His (H)

<220> 
<223> VL-CDR3

<400> 14
Xaa Gln Arg Ser Ser Tyr Pro Leu Thr Phe 
1               5                   10  

<210> 15
<211> 11
<212> PRT
<213> Artificial Sequence


<220> 
<223> VL-CDR1

<220> 
<221> SITE
<222> 8
<223> Xaa is absent or is selected from Asn (N), Ser (S) and Gly (G)

<400> 15
Ser Ala Ser Ser Ser Val Ser Xaa Tyr Met His 
1               5                   10      

<210> 16
<211> 7
<212> PRT
<213> Artificial Sequence


<220> 
<223> VL-CDR2

<400> 16
Asn Thr Ser Asn Leu Pro Ser 
1               5           

<210> 17
<211> 10
<212> PRT
<213> Artificial Sequence


<220> 
<223> VL-CDR3

<400> 17
Gln Gln Arg Ser Ser Tyr Pro Leu Thr Phe 
1               5                   10  

<210> 18
<211> 11
<212> PRT
<213> Artificial Sequence


<220> 
<223> VL-CDR1

<220> 
<221> SITE
<222> 8
<223> Xaa is absent or is selected from Asn (N), Ser (S) and Gly (G)

<400> 18
Arg Ala Ser Ser Ser Val Ser Xaa Tyr Met His 
1               5                   10      

<210> 19
<211> 7
<212> PRT
<213> Artificial Sequence


<220> 
<223> VL-CDR2

<400> 19
Asn Thr Ser Asn Ser Pro Ser 
1               5           

<210> 20
<211> 7
<212> PRT
<213> Artificial Sequence


<220> 
<223> VL-CDR2

<400> 20
Ala Thr Ser Asn Leu Gln Ser 
1               5           

<210> 21
<211> 10
<212> PRT
<213> Artificial Sequence


<220> 
<223> VL-CDR3

<400> 21
His Gln Arg Ser Ser Tyr Pro Leu Thr Phe 
1               5                   10  

<210> 22
<211> 7
<212> PRT
<213> Artificial Sequence


<220> 
<223> VL-CDR2

<400> 22
Asn Thr Ser Asn Arg Ala Thr 
1               5           

<210> 23
<211> 48
<212> PRT
<213> Homo sapiens


<220> 
<223> C determinant of hCD45RC

<400> 23
Asp Val Pro Gly Glu Arg Ser Thr Ala Ser Thr Phe Pro Thr Asp Pro 
1               5                   10                  15      
Val Ser Pro Leu Thr Thr Thr Leu Ser Leu Ala His His Ser Ser Ala 
            20                  25                  30          
Ala Leu Pro Ala Arg Thr Ser Asn Thr Thr Ile Thr Ala Asn Thr Ser 
        35                  40                  45              



<210> 24
<211> 144
<212> DNA
<213> Homo sapiens


<220> 
<223> Exon 6 of hCD45RC

<400> 24
gatgtcccag gagagaggag tacagccagc acctttccta cagacccagt ttccccattg     60

acaaccaccc tcagccttgc acaccacagc tctgctgcct tacctgcacg cacctccaac    120

accaccatca cagcgaacac ctca                                           144


<210> 25
<211> 30
<212> PRT
<213> Artificial Sequence


<220> 
<223> VH-FR1

<400> 25
Gln Val Gln Leu Gln Gln Ser Gly Ala Glu Leu Val Arg Pro Gly Thr 
1               5                   10                  15      
Ser Val Lys Met Ser Cys Lys Ala Ala Gly Tyr Thr Phe Thr 
            20                  25                  30  

<210> 26
<211> 14
<212> PRT
<213> Artificial Sequence


<220> 
<223> VH-FR2

<400> 26
Trp Val Lys Gln Arg Pro Gly His Gly Leu Glu Trp Ile Gly 
1               5                   10                  

<210> 27
<211> 32
<212> PRT
<213> Artificial Sequence


<220> 
<223> VH-FR3

<400> 27
Lys Ala Thr Leu Thr Ala Asp Thr Ser Ser Ser Thr Ala Tyr Met Gln 
1               5                   10                  15      
Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Ile Tyr Tyr Cys Val Arg 
            20                  25                  30          



<210> 28
<211> 11
<212> PRT
<213> Artificial Sequence


<220> 
<223> VH-FR4

<400> 28
Trp Gly Gln Gly Thr Thr Leu Thr Val Ser Ser 
1               5                   10      

<210> 29
<211> 30
<212> PRT
<213> Artificial Sequence


<220> 
<223> VH-FR1

<400> 29
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      
Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr 
            20                  25                  30  

<210> 30
<211> 14
<212> PRT
<213> Artificial Sequence


<220> 
<223> VH-FR2

<400> 30
Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Ile Gly 
1               5                   10                  

<210> 31
<211> 32
<212> PRT
<213> Artificial Sequence


<220> 
<223> VH-FR3

<400> 31
Arg Val Thr Leu Thr Ala Asp Thr Ser Ile Ser Thr Ala Tyr Met Glu 
1               5                   10                  15      
Leu Ser Arg Leu Arg Ser Asp Asp Thr Val Val Tyr Tyr Cys Val Arg 
            20                  25                  30          



<210> 32
<211> 11
<212> PRT
<213> Artificial Sequence


<220> 
<223> VH-FR4

<400> 32
Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
1               5                   10      

<210> 33
<211> 30
<212> PRT
<213> Artificial Sequence


<220> 
<223> VH-FR1

<400> 33
Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Glu 
1               5                   10                  15      
Ser Leu Lys Ile Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr 
            20                  25                  30  

<210> 34
<211> 14
<212> PRT
<213> Artificial Sequence


<220> 
<223> VH-FR2

<400> 34
Trp Val Arg Gln Met Pro Gly Lys Gly Leu Glu Trp Ile Gly 
1               5                   10                  

<210> 35
<211> 32
<212> PRT
<213> Artificial Sequence


<220> 
<223> VH-FR3

<400> 35
Gln Val Thr Leu Ser Ala Asp Lys Ser Ile Ser Thr Ala Tyr Leu Gln 
1               5                   10                  15      
Leu Ser Ser Leu Lys Ala Ser Asp Thr Ala Met Tyr Tyr Cys Val Arg 
            20                  25                  30          



<210> 36
<211> 30
<212> PRT
<213> Artificial Sequence


<220> 
<223> VH-FR1

<400> 36
Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Tyr Thr Phe Thr 
            20                  25                  30  

<210> 37
<211> 14
<212> PRT
<213> Artificial Sequence


<220> 
<223> VH-FR2

<400> 37
Trp Ile Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile Gly 
1               5                   10                  

<210> 38
<211> 32
<212> PRT
<213> Artificial Sequence


<220> 
<223> VH-FR3

<400> 38
Arg Phe Thr Leu Ser Ala Asp Thr Ala Lys Asn Ser Ala Tyr Leu Gln 
1               5                   10                  15      
Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Val Arg 
            20                  25                  30          



<210> 39
<211> 30
<212> PRT
<213> Artificial Sequence


<220> 
<223> VH-FR1

<400> 39
Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Glu 
1               5                   10                  15      
Ser Leu Lys Ile Ser Cys Lys Gly Ser Gly Tyr Thr Phe Thr 
            20                  25                  30  

<210> 40
<211> 30
<212> PRT
<213> Artificial Sequence


<220> 
<223> VH-FR1

<400> 40
Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser 
            20                  25                  30  

<210> 41
<211> 32
<212> PRT
<213> Artificial Sequence


<220> 
<223> VH-FR3

<400> 41
Arg Phe Thr Leu Ser Ala Asp Thr Ala Lys Asn Ser Leu Tyr Leu Gln 
1               5                   10                  15      
Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Val Arg 
            20                  25                  30          



<210> 42
<211> 30
<212> PRT
<213> Artificial Sequence


<220> 
<223> VH-FR1

<400> 42
Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Glu 
1               5                   10                  15      
Ser Leu Lys Ile Ser Cys Lys Gly Ser Gly Tyr Ser Phe Thr 
            20                  25                  30  

<210> 43
<211> 14
<212> PRT
<213> Artificial Sequence


<220> 
<223> VH-FR2

<400> 43
Trp Ile Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Gly 
1               5                   10                  

<210> 44
<211> 23
<212> PRT
<213> Artificial Sequence


<220> 
<223> VL-FR1

<400> 44
Gln Ile Val Leu Thr Gln Ser Pro Thr Ile Met Ser Ala Ser Pro Gly 
1               5                   10                  15      
Glu Lys Val Thr Ile Thr Cys 
            20              

<210> 45
<211> 15
<212> PRT
<213> Artificial Sequence


<220> 
<223> VL-FR2

<400> 45
Trp Phe Gln Gln Lys Thr Gly Thr Ser Pro Arg Leu Trp Ile Tyr 
1               5                   10                  15  

<210> 46
<211> 32
<212> PRT
<213> Artificial Sequence


<220> 
<223> VL-FR3

<220> 
<221> SITE
<222> 15
<223> Xaa is selected from Tyr (Y) and Phe (F)

<400> 46
Gly Val Pro Ala Arg Phe Ser Gly Ser Gly Ser Gly Thr Ser Xaa Ser 
1               5                   10                  15      
Leu Thr Ile Ser Arg Met Glu Ala Glu Asp Ala Ala Thr Tyr Tyr Cys 
            20                  25                  30          



<210> 47
<211> 9
<212> PRT
<213> Artificial Sequence


<220> 
<223> VL-FR4

<400> 47
Gly Ala Gly Thr Lys Leu Glu Leu Lys 
1               5                   

<210> 48
<211> 23
<212> PRT
<213> Artificial Sequence


<220> 
<223> VL-FR1

<400> 48
Asp Ile Gln Leu Thr Gln Ser Pro Ser Phe Leu Ser Ala Ser Val Gly 
1               5                   10                  15      
Asp Arg Val Thr Ile Thr Cys 
            20              

<210> 49
<211> 15
<212> PRT
<213> Artificial Sequence


<220> 
<223> VL-FR2

<400> 49
Trp Phe Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Trp Ile Tyr 
1               5                   10                  15  

<210> 50
<211> 32
<212> PRT
<213> Artificial Sequence


<220> 
<223> VL-FR3

<220> 
<221> SITE
<222> 15
<223> Xaa is selected from Tyr (Y) and Phe (F)

<400> 50
Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Glu Xaa Thr 
1               5                   10                  15      
Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys 
            20                  25                  30          



<210> 51
<211> 9
<212> PRT
<213> Artificial Sequence


<220> 
<223> VL-FR4

<400> 51
Gly Gly Gly Thr Lys Val Glu Ile Lys 
1               5                   

<210> 52
<211> 23
<212> PRT
<213> Artificial Sequence


<220> 
<223> VL-FR1

<400> 52
Glu Ile Val Leu Thr Gln Ser Pro Asp Phe Gln Ser Val Thr Pro Lys 
1               5                   10                  15      
Glu Lys Val Thr Ile Thr Cys 
            20              

<210> 53
<211> 15
<212> PRT
<213> Artificial Sequence


<220> 
<223> VL-FR2

<400> 53
Trp Phe Gln Gln Lys Pro Asp Gln Ser Pro Lys Leu Trp Ile Tyr 
1               5                   10                  15  

<210> 54
<211> 32
<212> PRT
<213> Artificial Sequence


<220> 
<223> VL-FR3

<220> 
<221> SITE
<222> 15
<223> Xaa is selected from Tyr (Y) and Phe (F)

<400> 54
Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Xaa Thr 
1               5                   10                  15      
Leu Thr Ile Asn Ser Leu Glu Ala Glu Asp Ala Ala Thr Tyr Tyr Cys 
            20                  25                  30          



<210> 55
<211> 23
<212> PRT
<213> Artificial Sequence


<220> 
<223> VL-FR1

<400> 55
Glu Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      
Glu Arg Ala Thr Leu Ser Cys 
            20              

<210> 56
<211> 15
<212> PRT
<213> Artificial Sequence


<220> 
<223> VL-FR2

<400> 56
Trp Phe Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Trp Ile Tyr 
1               5                   10                  15  

<210> 57
<211> 32
<212> PRT
<213> Artificial Sequence


<220> 
<223> VL-FR3

<220> 
<221> SITE
<222> 15
<223> Xaa is selected from Tyr (Y) and Phe (F)

<400> 57
Gly Ile Pro Ala Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Xaa Thr 
1               5                   10                  15      
Leu Thr Ile Ser Ser Leu Glu Pro Glu Asp Phe Ala Val Tyr Tyr Cys 
            20                  25                  30          



<210> 58
<211> 15
<212> PRT
<213> Artificial Sequence


<220> 
<223> VL-FR2

<400> 58
Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Trp Ile Tyr 
1               5                   10                  15  

<210> 59
<211> 15
<212> PRT
<213> Artificial Sequence


<220> 
<223> VL-FR2

<400> 59
Trp Tyr Gln Gln Lys Pro Asp Gln Ser Pro Lys Leu Trp Ile Tyr 
1               5                   10                  15  

<210> 60
<211> 15
<212> PRT
<213> Artificial Sequence


<220> 
<223> VL-FR2

<400> 60
Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Trp Ile Tyr 
1               5                   10                  15  

<210> 61
<211> 114
<212> PRT
<213> Artificial Sequence


<220> 
<223> Murine HCVR

<400> 61
Gln Val Gln Leu Gln Gln Ser Gly Ala Glu Leu Val Arg Pro Gly Thr 
1               5                   10                  15      
Ser Val Lys Met Ser Cys Lys Ala Ala Gly Tyr Thr Phe Thr Asn Tyr 
            20                  25                  30          
Tyr Ile Gly Trp Val Lys Gln Arg Pro Gly His Gly Leu Glu Trp Ile 
        35                  40                  45              
Gly Asp Ile Phe Pro Gly Gly Asp Tyr Ala Asn Ser Asn Glu Lys Phe 
    50                  55                  60                  
Lys Gly Lys Ala Thr Leu Thr Ala Asp Thr Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  
Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Ile Tyr Tyr Cys 
                85                  90                  95      
Val Arg Arg Asn Phe Asp Tyr Trp Gly Gln Gly Thr Thr Leu Thr Val 
            100                 105                 110         
Ser Ser 
        

<210> 62
<211> 114
<212> PRT
<213> Artificial Sequence


<220> 
<223> Humanized HCVR

<400> 62
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      
Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asn Tyr 
            20                  25                  30          
Tyr Ile Gly Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              
Gly Asp Ile Phe Pro Gly Gly Asp Tyr Ala Asn Ser Asn Glu Lys Phe 
    50                  55                  60                  
Lys Gly Arg Val Thr Leu Thr Ala Asp Thr Ser Ile Ser Thr Ala Tyr 
65                  70                  75                  80  
Met Glu Leu Ser Arg Leu Arg Ser Asp Asp Thr Val Val Tyr Tyr Cys 
                85                  90                  95      
Val Arg Arg Asn Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val 
            100                 105                 110         
Ser Ser 
        

<210> 63
<211> 114
<212> PRT
<213> Artificial Sequence


<220> 
<223> Humanized HCVR

<400> 63
Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Glu 
1               5                   10                  15      
Ser Leu Lys Ile Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asn Tyr 
            20                  25                  30          
Tyr Ile Gly Trp Val Arg Gln Met Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              
Gly Asp Ile Phe Pro Gly Gly Asp Tyr Ala Asn Ser Asn Glu Lys Phe 
    50                  55                  60                  
Lys Gly Gln Val Thr Leu Ser Ala Asp Lys Ser Ile Ser Thr Ala Tyr 
65                  70                  75                  80  
Leu Gln Leu Ser Ser Leu Lys Ala Ser Asp Thr Ala Met Tyr Tyr Cys 
                85                  90                  95      
Val Arg Arg Asn Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val 
            100                 105                 110         
Ser Ser 
        

<210> 64
<211> 114
<212> PRT
<213> Artificial Sequence


<220> 
<223> Humanized HCVR

<400> 64
Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Tyr Thr Phe Thr Asn Tyr 
            20                  25                  30          
Tyr Ile Gly Trp Ile Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              
Gly Asp Ile Phe Pro Gly Gly Asp Tyr Ala Asn Ser Asn Glu Lys Val 
    50                  55                  60                  
Lys Gly Arg Phe Thr Leu Ser Ala Asp Thr Ala Lys Asn Ser Ala Tyr 
65                  70                  75                  80  
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      
Val Arg Arg Asn Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val 
            100                 105                 110         
Ser Ser 
        

<210> 65
<211> 114
<212> PRT
<213> Artificial Sequence


<220> 
<223> Humanized HCVR

<400> 65
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      
Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asn Tyr 
            20                  25                  30          
Tyr Ile Gly Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              
Gly Asp Ile Phe Pro Gly Gly Gly Tyr Thr Asn Tyr Ala Glu Lys Phe 
    50                  55                  60                  
Gln Gly Arg Val Thr Leu Thr Ala Asp Thr Ser Ile Ser Thr Ala Tyr 
65                  70                  75                  80  
Met Glu Leu Ser Arg Leu Arg Ser Asp Asp Thr Val Val Tyr Tyr Cys 
                85                  90                  95      
Val Arg Arg Asn Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val 
            100                 105                 110         
Ser Ser 
        

<210> 66
<211> 114
<212> PRT
<213> Artificial Sequence


<220> 
<223> Humanized HCVR

<400> 66
Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Glu 
1               5                   10                  15      
Ser Leu Lys Ile Ser Cys Lys Gly Ser Gly Tyr Thr Phe Thr Asn Tyr 
            20                  25                  30          
Tyr Ile Gly Trp Val Arg Gln Met Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              
Gly Asp Ile Phe Pro Gly Gly Ser Tyr Thr Asn Tyr Ser Glu Ser Phe 
    50                  55                  60                  
Gln Gly Gln Val Thr Leu Ser Ala Asp Lys Ser Ile Ser Thr Ala Tyr 
65                  70                  75                  80  
Leu Gln Leu Ser Ser Leu Lys Ala Ser Asp Thr Ala Met Tyr Tyr Cys 
                85                  90                  95      
Val Arg Arg Asn Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val 
            100                 105                 110         
Ser Ser 
        

<210> 67
<211> 114
<212> PRT
<213> Artificial Sequence


<220> 
<223> Humanized HCVR

<400> 67
Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Tyr 
            20                  25                  30          
Tyr Ile Gly Trp Ile Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              
Gly Asp Ile Phe Pro Gly Gly Ser Tyr Thr Asn Tyr Ala Asp Ser Val 
    50                  55                  60                  
Lys Gly Arg Phe Thr Leu Ser Ala Asp Thr Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      
Val Arg Arg Asn Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val 
            100                 105                 110         
Ser Ser 
        

<210> 68
<211> 114
<212> PRT
<213> Artificial Sequence


<220> 
<223> Humanized HCVR

<400> 68
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      
Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asn Tyr 
            20                  25                  30          
Tyr Ile Gly Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              
Gly Arg Ile Phe Pro Gly Gly Gly Tyr Thr Asn Tyr Ala Gln Lys Phe 
    50                  55                  60                  
Gln Gly Arg Val Thr Leu Thr Ala Asp Thr Ser Ile Ser Thr Ala Tyr 
65                  70                  75                  80  
Met Glu Leu Ser Arg Leu Arg Ser Asp Asp Thr Val Val Tyr Tyr Cys 
                85                  90                  95      
Val Arg Arg Asn Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val 
            100                 105                 110         
Ser Ser 
        

<210> 69
<211> 114
<212> PRT
<213> Artificial Sequence


<220> 
<223> Humanized HCVR

<400> 69
Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Glu 
1               5                   10                  15      
Ser Leu Lys Ile Ser Cys Lys Gly Ser Gly Tyr Ser Phe Thr Asn Tyr 
            20                  25                  30          
Tyr Ile Gly Trp Val Arg Gln Met Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              
Gly Ile Ile Phe Pro Gly Gly Ser Tyr Thr Asn Tyr Ser Pro Ser Phe 
    50                  55                  60                  
Gln Gly Gln Val Thr Leu Ser Ala Asp Lys Ser Ile Ser Thr Ala Tyr 
65                  70                  75                  80  
Leu Gln Leu Ser Ser Leu Lys Ala Ser Asp Thr Ala Met Tyr Tyr Cys 
                85                  90                  95      
Val Arg Arg Asn Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val 
            100                 105                 110         
Ser Ser 
        

<210> 70
<211> 114
<212> PRT
<213> Artificial Sequence


<220> 
<223> Humanized HCVR

<400> 70
Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Tyr 
            20                  25                  30          
Tyr Ile Gly Trp Ile Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              
Gly Asp Ile Phe Ser Gly Gly Ser Tyr Thr Asn Tyr Ala Asp Ser Val 
    50                  55                  60                  
Lys Gly Arg Phe Thr Leu Ser Ala Asp Thr Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      
Val Arg Arg Asn Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val 
            100                 105                 110         
Ser Ser 
        

<210> 71
<211> 107
<212> PRT
<213> Artificial Sequence


<220> 
<223> Murine LCVR

<220> 
<221> SITE
<222> 31
<223> Xaa is selected from Asn (N), Ser (S) and Gly (G)

<400> 71
Gln Ile Val Leu Thr Gln Ser Pro Thr Ile Met Ser Ala Ser Pro Gly 
1               5                   10                  15      
Glu Lys Val Thr Ile Thr Cys Ser Ala Ser Ser Ser Val Ser Xaa Tyr 
            20                  25                  30          
Met His Trp Phe Gln Gln Lys Thr Gly Thr Ser Pro Arg Leu Trp Ile 
        35                  40                  45              
Tyr Asn Thr Ser Asn Leu Pro Ser Gly Val Pro Ala Arg Phe Ser Gly 
    50                  55                  60                  
Ser Gly Ser Gly Thr Ser Phe Ser Leu Thr Ile Ser Arg Met Glu Ala 
65                  70                  75                  80  
Glu Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Arg Ser Ser Tyr Pro Leu 
                85                  90                  95      
Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys 
            100                 105         

<210> 72
<211> 107
<212> PRT
<213> Artificial Sequence


<220> 
<223> Humanized LCVR

<220> 
<221> SITE
<222> 31
<223> Xaa is selected from Asn (N), Ser (S) and Gly (G)

<400> 72
Asp Ile Gln Leu Thr Gln Ser Pro Ser Phe Leu Ser Ala Ser Val Gly 
1               5                   10                  15      
Asp Arg Val Thr Ile Thr Cys Ser Ala Ser Ser Ser Val Ser Xaa Tyr 
            20                  25                  30          
Met His Trp Phe Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Trp Ile 
        35                  40                  45              
Tyr Asn Thr Ser Asn Leu Pro Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  
Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  
Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Arg Ser Ser Tyr Pro Leu 
                85                  90                  95      
Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105         

<210> 73
<211> 107
<212> PRT
<213> Artificial Sequence


<220> 
<223> Humanized LCVR

<220> 
<221> SITE
<222> 31
<223> Xaa is selected from Asn (N), Ser (S) and Gly (G)

<400> 73
Glu Ile Val Leu Thr Gln Ser Pro Asp Phe Gln Ser Val Thr Pro Lys 
1               5                   10                  15      
Glu Lys Val Thr Ile Thr Cys Ser Ala Ser Ser Ser Val Ser Xaa Tyr 
            20                  25                  30          
Met His Trp Phe Gln Gln Lys Pro Asp Gln Ser Pro Lys Leu Trp Ile 
        35                  40                  45              
Tyr Asn Thr Ser Asn Leu Pro Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Asn Ser Leu Glu Ala 
65                  70                  75                  80  
Glu Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Arg Ser Ser Tyr Pro Leu 
                85                  90                  95      
Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105         

<210> 74
<211> 107
<212> PRT
<213> Artificial Sequence


<220> 
<223> Humanized LCVR

<220> 
<221> SITE
<222> 31
<223> Xaa is selected from Asn (N), Ser (S) and Gly (G)

<400> 74
Glu Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      
Glu Arg Ala Thr Leu Ser Cys Ser Ala Ser Ser Ser Val Ser Xaa Tyr 
            20                  25                  30          
Met His Trp Phe Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Trp Ile 
        35                  40                  45              
Tyr Asn Thr Ser Asn Leu Pro Ser Gly Ile Pro Ala Arg Phe Ser Gly 
    50                  55                  60                  
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Glu Pro 
65                  70                  75                  80  
Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Arg Ser Ser Tyr Pro Leu 
                85                  90                  95      
Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105         

<210> 75
<211> 107
<212> PRT
<213> Artificial Sequence


<220> 
<223> Humanized LCVR

<220> 
<221> SITE
<222> 31
<223> Xaa is selected from Asn (N), Ser (S) and Gly (G)

<400> 75
Asp Ile Gln Leu Thr Gln Ser Pro Ser Phe Leu Ser Ala Ser Val Gly 
1               5                   10                  15      
Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Ser Ser Val Ser Xaa Tyr 
            20                  25                  30          
Met His Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Trp Ile 
        35                  40                  45              
Tyr Asn Thr Ser Asn Leu Pro Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  
Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  
Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Arg Ser Ser Tyr Pro Leu 
                85                  90                  95      
Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105         

<210> 76
<211> 107
<212> PRT
<213> Artificial Sequence


<220> 
<223> Humanized LCVR

<220> 
<221> SITE
<222> 31
<223> Xaa is selected from Asn (N), Ser (S) and Gly (G)

<400> 76
Glu Ile Val Leu Thr Gln Ser Pro Asp Phe Gln Ser Val Thr Pro Lys 
1               5                   10                  15      
Glu Lys Val Thr Ile Thr Cys Arg Ala Ser Ser Ser Val Ser Xaa Tyr 
            20                  25                  30          
Met His Trp Tyr Gln Gln Lys Pro Asp Gln Ser Pro Lys Leu Trp Ile 
        35                  40                  45              
Tyr Asn Thr Ser Asn Ser Pro Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Asn Ser Leu Glu Ala 
65                  70                  75                  80  
Glu Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Arg Ser Ser Tyr Pro Leu 
                85                  90                  95      
Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105         

<210> 77
<211> 107
<212> PRT
<213> Artificial Sequence


<220> 
<223> Humanized LCVR

<220> 
<221> SITE
<222> 31
<223> Xaa is selected from Asn (N), Ser (S) and Gly (G)

<400> 77
Glu Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      
Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Ser Ser Val Ser Xaa Tyr 
            20                  25                  30          
Met His Trp Phe Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Trp Ile 
        35                  40                  45              
Tyr Asn Thr Ser Asn Leu Pro Ser Gly Ile Pro Ala Arg Phe Ser Gly 
    50                  55                  60                  
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Glu Pro 
65                  70                  75                  80  
Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Arg Ser Ser Tyr Pro Leu 
                85                  90                  95      
Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105         

<210> 78
<211> 107
<212> PRT
<213> Artificial Sequence


<220> 
<223> Humanized LCVR

<220> 
<221> SITE
<222> 31
<223> Xaa is selected from Asn (N), Ser (S) and Gly (G)

<400> 78
Asp Ile Gln Leu Thr Gln Ser Pro Ser Phe Leu Ser Ala Ser Val Gly 
1               5                   10                  15      
Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Ser Ser Val Ser Xaa Tyr 
            20                  25                  30          
Met His Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Trp Ile 
        35                  40                  45              
Tyr Ala Thr Ser Asn Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  
Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  
Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Arg Ser Ser Tyr Pro Leu 
                85                  90                  95      
Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105         

<210> 79
<211> 107
<212> PRT
<213> Artificial Sequence


<220> 
<223> Humanized LCVR

<220> 
<221> SITE
<222> 31
<223> Xaa is selected from Asn (N), Ser (S) and Gly (G)

<400> 79
Glu Ile Val Leu Thr Gln Ser Pro Asp Phe Gln Ser Val Thr Pro Lys 
1               5                   10                  15      
Glu Lys Val Thr Ile Thr Cys Arg Ala Ser Ser Ser Val Ser Xaa Tyr 
            20                  25                  30          
Met His Trp Tyr Gln Gln Lys Pro Asp Gln Ser Pro Lys Leu Trp Ile 
        35                  40                  45              
Tyr Asn Thr Ser Asn Ser Pro Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Asn Ser Leu Glu Ala 
65                  70                  75                  80  
Glu Asp Ala Ala Thr Tyr Tyr Cys His Gln Arg Ser Ser Tyr Pro Leu 
                85                  90                  95      
Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105         

<210> 80
<211> 107
<212> PRT
<213> Artificial Sequence


<220> 
<223> Humanized LCVR

<220> 
<221> SITE
<222> 31
<223> Xaa is selected from Asn (N), Ser (S) and Gly (G)

<400> 80
Glu Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      
Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Ser Ser Val Ser Xaa Tyr 
            20                  25                  30          
Met His Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Trp Ile 
        35                  40                  45              
Tyr Asn Thr Ser Asn Arg Ala Thr Gly Ile Pro Ala Arg Phe Ser Gly 
    50                  55                  60                  
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Glu Pro 
65                  70                  75                  80  
Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Arg Ser Ser Tyr Pro Leu 
                85                  90                  95      
Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105         

<210> 81
<211> 106
<212> PRT
<213> Artificial Sequence


<220> 
<223> Murine LCVR

<400> 81
Gln Ile Val Leu Thr Gln Ser Pro Thr Ile Met Ser Ala Ser Pro Gly 
1               5                   10                  15      
Glu Lys Val Thr Ile Thr Cys Ser Ala Ser Ser Ser Val Ser Tyr Met 
            20                  25                  30          
His Trp Phe Gln Gln Lys Thr Gly Thr Ser Pro Arg Leu Trp Ile Tyr 
        35                  40                  45              
Asn Thr Ser Asn Leu Pro Ser Gly Val Pro Ala Arg Phe Ser Gly Ser 
    50                  55                  60                  
Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile Ser Arg Met Glu Ala Glu 
65                  70                  75                  80  
Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Arg Ser Ser Tyr Pro Leu Thr 
                85                  90                  95      
Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys 
            100                 105     

<210> 82
<211> 106
<212> PRT
<213> Artificial Sequence


<220> 
<223> Humanized LCVR

<400> 82
Asp Ile Gln Leu Thr Gln Ser Pro Ser Phe Leu Ser Ala Ser Val Gly 
1               5                   10                  15      
Asp Arg Val Thr Ile Thr Cys Ser Ala Ser Ser Ser Val Ser Tyr Met 
            20                  25                  30          
His Trp Phe Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Trp Ile Tyr 
        35                  40                  45              
Asn Thr Ser Asn Leu Pro Ser Gly Val Pro Ser Arg Phe Ser Gly Ser 
    50                  55                  60                  
Gly Ser Gly Thr Glu Tyr Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu 
65                  70                  75                  80  
Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Arg Ser Ser Tyr Pro Leu Thr 
                85                  90                  95      
Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105     

<210> 83
<211> 106
<212> PRT
<213> Artificial Sequence


<220> 
<223> Humanized LCVR

<400> 83
Glu Ile Val Leu Thr Gln Ser Pro Asp Phe Gln Ser Val Thr Pro Lys 
1               5                   10                  15      
Glu Lys Val Thr Ile Thr Cys Ser Ala Ser Ser Ser Val Ser Tyr Met 
            20                  25                  30          
His Trp Phe Gln Gln Lys Pro Asp Gln Ser Pro Lys Leu Trp Ile Tyr 
        35                  40                  45              
Asn Thr Ser Asn Leu Pro Ser Gly Val Pro Ser Arg Phe Ser Gly Ser 
    50                  55                  60                  
Gly Ser Gly Thr Asp Tyr Thr Leu Thr Ile Asn Ser Leu Glu Ala Glu 
65                  70                  75                  80  
Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Arg Ser Ser Tyr Pro Leu Thr 
                85                  90                  95      
Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105     

<210> 84
<211> 106
<212> PRT
<213> Artificial Sequence


<220> 
<223> Humanized LCVR

<400> 84
Glu Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      
Glu Arg Ala Thr Leu Ser Cys Ser Ala Ser Ser Ser Val Ser Tyr Met 
            20                  25                  30          
His Trp Phe Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Trp Ile Tyr 
        35                  40                  45              
Asn Thr Ser Asn Leu Pro Ser Gly Ile Pro Ala Arg Phe Ser Gly Ser 
    50                  55                  60                  
Gly Ser Gly Thr Asp Tyr Thr Leu Thr Ile Ser Ser Leu Glu Pro Glu 
65                  70                  75                  80  
Asp Phe Ala Val Tyr Tyr Cys Gln Gln Arg Ser Ser Tyr Pro Leu Thr 
                85                  90                  95      
Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105     

<210> 85
<211> 106
<212> PRT
<213> Artificial Sequence


<220> 
<223> Humanized LCVR

<400> 85
Asp Ile Gln Leu Thr Gln Ser Pro Ser Phe Leu Ser Ala Ser Val Gly 
1               5                   10                  15      
Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Ser Ser Val Ser Tyr Met 
            20                  25                  30          
His Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Trp Ile Tyr 
        35                  40                  45              
Asn Thr Ser Asn Leu Pro Ser Gly Val Pro Ser Arg Phe Ser Gly Ser 
    50                  55                  60                  
Gly Ser Gly Thr Glu Tyr Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu 
65                  70                  75                  80  
Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Arg Ser Ser Tyr Pro Leu Thr 
                85                  90                  95      
Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105     

<210> 86
<211> 106
<212> PRT
<213> Artificial Sequence


<220> 
<223> Humanized LCVR

<400> 86
Glu Ile Val Leu Thr Gln Ser Pro Asp Phe Gln Ser Val Thr Pro Lys 
1               5                   10                  15      
Glu Lys Val Thr Ile Thr Cys Arg Ala Ser Ser Ser Val Ser Tyr Met 
            20                  25                  30          
His Trp Tyr Gln Gln Lys Pro Asp Gln Ser Pro Lys Leu Trp Ile Tyr 
        35                  40                  45              
Asn Thr Ser Asn Ser Pro Ser Gly Val Pro Ser Arg Phe Ser Gly Ser 
    50                  55                  60                  
Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Asn Ser Leu Glu Ala Glu 
65                  70                  75                  80  
Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Arg Ser Ser Tyr Pro Leu Thr 
                85                  90                  95      
Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105     

<210> 87
<211> 106
<212> PRT
<213> Artificial Sequence


<220> 
<223> Humanized LCVR

<400> 87
Glu Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      
Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Ser Ser Val Ser Tyr Met 
            20                  25                  30          
His Trp Phe Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Trp Ile Tyr 
        35                  40                  45              
Asn Thr Ser Asn Leu Pro Ser Gly Ile Pro Ala Arg Phe Ser Gly Ser 
    50                  55                  60                  
Gly Ser Gly Thr Asp Tyr Thr Leu Thr Ile Ser Ser Leu Glu Pro Glu 
65                  70                  75                  80  
Asp Phe Ala Val Tyr Tyr Cys Gln Gln Arg Ser Ser Tyr Pro Leu Thr 
                85                  90                  95      
Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105     

<210> 88
<211> 106
<212> PRT
<213> Artificial Sequence


<220> 
<223> Humanized LCVR

<400> 88
Asp Ile Gln Leu Thr Gln Ser Pro Ser Phe Leu Ser Ala Ser Val Gly 
1               5                   10                  15      
Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Ser Ser Val Ser Tyr Met 
            20                  25                  30          
His Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Trp Ile Tyr 
        35                  40                  45              
Ala Thr Ser Asn Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly Ser 
    50                  55                  60                  
Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu 
65                  70                  75                  80  
Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Arg Ser Ser Tyr Pro Leu Thr 
                85                  90                  95      
Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105     

<210> 89
<211> 106
<212> PRT
<213> Artificial Sequence


<220> 
<223> Humanized LCVR

<400> 89
Glu Ile Val Leu Thr Gln Ser Pro Asp Phe Gln Ser Val Thr Pro Lys 
1               5                   10                  15      
Glu Lys Val Thr Ile Thr Cys Arg Ala Ser Ser Ser Val Ser Tyr Met 
            20                  25                  30          
His Trp Tyr Gln Gln Lys Pro Asp Gln Ser Pro Lys Leu Trp Ile Tyr 
        35                  40                  45              
Asn Thr Ser Asn Ser Pro Ser Gly Val Pro Ser Arg Phe Ser Gly Ser 
    50                  55                  60                  
Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Asn Ser Leu Glu Ala Glu 
65                  70                  75                  80  
Asp Ala Ala Thr Tyr Tyr Cys His Gln Arg Ser Ser Tyr Pro Leu Thr 
                85                  90                  95      
Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105     

<210> 90
<211> 106
<212> PRT
<213> Artificial Sequence


<220> 
<223> Humanized LCVR

<400> 90
Glu Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      
Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Ser Ser Val Ser Tyr Met 
            20                  25                  30          
His Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Trp Ile Tyr 
        35                  40                  45              
Asn Thr Ser Asn Arg Ala Thr Gly Ile Pro Ala Arg Phe Ser Gly Ser 
    50                  55                  60                  
Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Glu Pro Glu 
65                  70                  75                  80  
Asp Phe Ala Val Tyr Tyr Cys Gln Gln Arg Ser Ser Tyr Pro Leu Thr 
                85                  90                  95      
Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105     

<210> 91
<211> 330
<212> PRT
<213> Artificial Sequence


<220> 
<223> Human HCCR

<400> 91
Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys 
1               5                   10                  15      
Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
            20                  25                  30          
Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        35                  40                  45              
Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  
Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr 
65                  70                  75                  80  
Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys 
                85                  90                  95      
Arg Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys 
            100                 105                 110         
Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro 
        115                 120                 125             
Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys 
    130                 135                 140                 
Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp 
145                 150                 155                 160 
Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu 
                165                 170                 175     
Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu 
            180                 185                 190         
His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn 
        195                 200                 205             
Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly 
    210                 215                 220                 
Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu 
225                 230                 235                 240 
Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr 
                245                 250                 255     
Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn 
            260                 265                 270         
Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe 
        275                 280                 285             
Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn 
    290                 295                 300                 
Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr 
305                 310                 315                 320 
Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
                325                 330 

<210> 92
<211> 107
<212> PRT
<213> Artificial Sequence


<220> 
<223> Human LCCR

<400> 92
Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu 
1               5                   10                  15      
Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe 
            20                  25                  30          
Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln 
        35                  40                  45              
Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser 
    50                  55                  60                  
Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu 
65                  70                  75                  80  
Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser 
                85                  90                  95      
Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
            100                 105         

<210> 93
<211> 323
<212> PRT
<213> Artificial Sequence


<220> 
<223> Murine HCCR

<400> 93
Ala Lys Thr Thr Pro Pro Ser Val Tyr Pro Leu Ala Pro Gly Ser Ala 
1               5                   10                  15      
Ala Gln Thr Asn Ser Met Val Thr Leu Gly Cys Leu Val Lys Gly Tyr 
            20                  25                  30          
Phe Pro Glu Pro Val Thr Val Thr Trp Asn Ser Gly Ser Leu Ser Ser 
        35                  40                  45              
Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Asp Leu Tyr Thr Leu 
    50                  55                  60                  
Ser Ser Ser Val Thr Val Pro Ser Ser Thr Trp Pro Ser Glu Thr Val 
65                  70                  75                  80  
Thr Cys Asn Val Ala His Pro Ala Ser Ser Thr Lys Val Asp Lys Lys 
                85                  90                  95      
Ile Val Pro Arg Asp Cys Gly Cys Lys Pro Cys Ile Cys Thr Val Pro 
            100                 105                 110         
Glu Val Ser Ser Val Phe Ile Phe Pro Pro Lys Pro Lys Asp Val Leu 
        115                 120                 125             
Thr Ile Thr Leu Thr Pro Lys Val Thr Cys Val Val Val Asp Ile Ser 
    130                 135                 140                 
Lys Asp Asp Pro Glu Val Gln Phe Ser Trp Phe Val Asp Asp Val Glu 
145                 150                 155                 160 
Val His Thr Ala Gln Thr Gln Pro Arg Glu Glu Gln Phe Asn Ser Thr 
                165                 170                 175     
Phe Arg Ser Val Ser Glu Leu Pro Ile Met His Gln Asp Trp Leu Asn 
            180                 185                 190         
Gly Lys Glu Phe Lys Cys Arg Val Asn Ser Ala Ala Phe Pro Ala Pro 
        195                 200                 205             
Ile Glu Lys Thr Ile Ser Lys Thr Lys Gly Arg Pro Lys Ala Pro Gln 
    210                 215                 220                 
Val Tyr Thr Ile Pro Pro Pro Lys Glu Gln Met Ala Lys Asp Lys Val 
225                 230                 235                 240 
Ser Leu Thr Cys Met Ile Thr Asp Phe Phe Pro Glu Asp Ile Thr Val 
                245                 250                 255     
Glu Trp Gln Trp Asn Gly Gln Pro Ala Glu Asn Tyr Lys Asn Thr Gln 
            260                 265                 270         
Pro Ile Met Asp Thr Asp Gly Ser Tyr Phe Val Tyr Ser Lys Leu Asn 
        275                 280                 285             
Val Gln Lys Ser Asn Trp Glu Ala Gly Asn Thr Phe Thr Cys Ser Val 
    290                 295                 300                 
Leu His Glu Gly Leu His Asn His His Thr Glu Lys Ser Leu Ser His 
305                 310                 315                 320 
Ser Pro Gly 
            

<210> 94
<211> 107
<212> PRT
<213> Artificial Sequence


<220> 
<223> Murine LCCR

<400> 94
Arg Ala Asp Ala Ala Pro Thr Val Ser Ile Phe Pro Pro Ser Ser Glu 
1               5                   10                  15      
Gln Leu Thr Ser Gly Gly Ala Ser Val Val Cys Phe Leu Asn Asn Phe 
            20                  25                  30          
Tyr Pro Lys Asp Ile Asn Val Lys Trp Lys Ile Asp Gly Ser Glu Arg 
        35                  40                  45              
Gln Asn Gly Val Leu Asn Ser Trp Thr Asp Gln Asp Ser Lys Asp Ser 
    50                  55                  60                  
Thr Tyr Ser Met Ser Ser Thr Leu Thr Leu Thr Lys Asp Glu Tyr Glu 
65                  70                  75                  80  
Arg His Asn Ser Tyr Thr Cys Glu Ala Thr His Lys Thr Ser Thr Ser 
                85                  90                  95      
Pro Ile Val Lys Ser Phe Asn Arg Asn Glu Cys 
            100                 105         

<210> 95
<211> 342
<212> DNA
<213> Artificial Sequence


<220> 
<223> Murine HCVR

<400> 95
caggtccagc tgcaacagtc tggcgctgag ctggttaggc ctgggacttc agtgaagatg      60

tcctgcaagg ccgctggata caccttcact aactactaca taggttgggt aaagcagagg     120

cctggacatg gccttgagtg gatcggagat attttccctg gaggtgacta tgccaacagc     180

aatgagaagt tcaagggcaa agccacactg actgcagaca catcctccag cacagcctac     240

atgcagctca gcagcctgac atctgaggac tctgccatct attactgtgt gagaaggaac     300

tttgactact ggggccaagg caccactctc acagtgtcct ca                        342


<210> 96
<211> 318
<212> DNA
<213> Artificial Sequence


<220> 
<223> Murine LCVR

<400> 96
caaattgttc tcacccagtc tccaacaatc atgtctgcat ctccagggga gaaggtgacc      60

ataacctgca gtgccagctc aagtgtaagt tacatgcact ggttccagca gaagacaggc     120

acttctccca gactctggat ttataacaca tccaacctgc cttctggagt ccccgctcgc     180

ttcagtggca gtggatctgg gacctcttac tctctcacaa tcagccgaat ggaggctgaa     240

gatgctgcca cttattactg ccagcaaagg agtagttacc cactcacgtt cggtgctggg     300

accaagctgg agctgaaa                                                   318


<210> 97
<211> 990
<212> DNA
<213> Artificial Sequence


<220> 
<223> Human HCCR

<400> 97
gcctccacca agggcccatc ggtcttcccc ctggcaccct cctccaagag cacctctggg      60

ggcacagcgg ccctgggctg cctggtcaag gactacttcc ccgaaccggt gacggtgtcg     120

tggaactcag gcgccctgac cagcggcgtg cacaccttcc cggctgtcct acagtcctca     180

ggactctact ccctcagcag cgtggtgacc gtgccctcca gcagcttggg cacccagacc     240

tacatctgca acgtgaatca caagcccagc aacaccaagg tggacaagag agttgagccc     300

aaatcttgtg acaaaactca cacatgccca ccgtgcccag cacctgaact cctgggggga     360

ccgtcagtct tcctcttccc cccaaaaccc aaggacaccc tcatgatctc ccggacccct     420

gaggtcacat gcgtggtggt ggacgtgagc cacgaagacc ctgaggtcaa gttcaactgg     480

tacgtggacg gcgtggaggt gcataatgcc aagacaaagc cgcgggagga gcagtacaac     540

agcacgtacc gtgtggtcag cgtcctcacc gtcctgcacc aggactggct gaatggcaag     600

gagtacaagt gcaaggtctc caacaaagcc ctcccagccc ccatcgagaa aaccatctcc     660

aaagccaaag ggcagccccg agaaccacag gtgtacaccc tgcccccatc ccgggaggag     720

atgaccaaga accaggtcag cctgacctgc ctggtcaaag gcttctatcc cagcgacatc     780

gccgtggagt gggagagcaa tgggcagccg gagaacaact acaagaccac gcctcccgtg     840

ctggactccg acggctcctt cttcctctat agcaagctca ccgtggacaa gagcaggtgg     900

cagcagggga acgtcttctc atgctccgtg atgcatgagg ctctgcacaa ccactacacg     960

cagaagagcc tctccctgtc cccgggtaaa                                      990


<210> 98
<211> 321
<212> DNA
<213> Artificial Sequence


<220> 
<223> Human LCCR

<400> 98
cgaactgtgg ctgcaccatc tgtcttcatc ttcccgccat ctgatgagca gttgaaatct      60

ggaactgcct ctgttgtgtg cctgctgaat aacttctatc ccagagaggc caaagtacag     120

tggaaggtgg ataacgccct ccaatcgggt aactcccagg agagtgtcac agagcaggac     180

agcaaggaca gcacctacag cctcagcagc accctgacgc tgagcaaagc agactacgag     240

aaacacaaag tctacgcctg cgaagtcacc catcagggcc tgagctcgcc cgtcacaaag     300

agcttcaaca ggggagagtg t                                               321


<210> 99
<211> 1306
<212> PRT
<213> Homo sapiens


<220> 
<223> hCD45

<300> 
<308> UniProt Accession P08575-3
<309> 2018 03 28

<400> 99
Met Thr Met Tyr Leu Trp Leu Lys Leu Leu Ala Phe Gly Phe Ala Phe 
1               5                   10                  15      
Leu Asp Thr Glu Val Phe Val Thr Gly Gln Ser Pro Thr Pro Ser Pro 
            20                  25                  30          
Thr Gly Leu Thr Thr Ala Lys Met Pro Ser Val Pro Leu Ser Ser Asp 
        35                  40                  45              
Pro Leu Pro Thr His Thr Thr Ala Phe Ser Pro Ala Ser Thr Phe Glu 
    50                  55                  60                  
Arg Glu Asn Asp Phe Ser Glu Thr Thr Thr Ser Leu Ser Pro Asp Asn 
65                  70                  75                  80  
Thr Ser Thr Gln Val Ser Pro Asp Ser Leu Asp Asn Ala Ser Ala Phe 
                85                  90                  95      
Asn Thr Thr Gly Val Ser Ser Val Gln Thr Pro His Leu Pro Thr His 
            100                 105                 110         
Ala Asp Ser Gln Thr Pro Ser Ala Gly Thr Asp Thr Gln Thr Phe Ser 
        115                 120                 125             
Gly Ser Ala Ala Asn Ala Lys Leu Asn Pro Thr Pro Gly Ser Asn Ala 
    130                 135                 140                 
Ile Ser Asp Val Pro Gly Glu Arg Ser Thr Ala Ser Thr Phe Pro Thr 
145                 150                 155                 160 
Asp Pro Val Ser Pro Leu Thr Thr Thr Leu Ser Leu Ala His His Ser 
                165                 170                 175     
Ser Ala Ala Leu Pro Ala Arg Thr Ser Asn Thr Thr Ile Thr Ala Asn 
            180                 185                 190         
Thr Ser Asp Ala Tyr Leu Asn Ala Ser Glu Thr Thr Thr Leu Ser Pro 
        195                 200                 205             
Ser Gly Ser Ala Val Ile Ser Thr Thr Thr Ile Ala Thr Thr Pro Ser 
    210                 215                 220                 
Lys Pro Thr Cys Asp Glu Lys Tyr Ala Asn Ile Thr Val Asp Tyr Leu 
225                 230                 235                 240 
Tyr Asn Lys Glu Thr Lys Leu Phe Thr Ala Lys Leu Asn Val Asn Glu 
                245                 250                 255     
Asn Val Glu Cys Gly Asn Asn Thr Cys Thr Asn Asn Glu Val His Asn 
            260                 265                 270         
Leu Thr Glu Cys Lys Asn Ala Ser Val Ser Ile Ser His Asn Ser Cys 
        275                 280                 285             
Thr Ala Pro Asp Lys Thr Leu Ile Leu Asp Val Pro Pro Gly Val Glu 
    290                 295                 300                 
Lys Phe Gln Leu His Asp Cys Thr Gln Val Glu Lys Ala Asp Thr Thr 
305                 310                 315                 320 
Ile Cys Leu Lys Trp Lys Asn Ile Glu Thr Phe Thr Cys Asp Thr Gln 
                325                 330                 335     
Asn Ile Thr Tyr Arg Phe Gln Cys Gly Asn Met Ile Phe Asp Asn Lys 
            340                 345                 350         
Glu Ile Lys Leu Glu Asn Leu Glu Pro Glu His Glu Tyr Lys Cys Asp 
        355                 360                 365             
Ser Glu Ile Leu Tyr Asn Asn His Lys Phe Thr Asn Ala Ser Lys Ile 
    370                 375                 380                 
Ile Lys Thr Asp Phe Gly Ser Pro Gly Glu Pro Gln Ile Ile Phe Cys 
385                 390                 395                 400 
Arg Ser Glu Ala Ala His Gln Gly Val Ile Thr Trp Asn Pro Pro Gln 
                405                 410                 415     
Arg Ser Phe His Asn Phe Thr Leu Cys Tyr Ile Lys Glu Thr Glu Lys 
            420                 425                 430         
Asp Cys Leu Asn Leu Asp Lys Asn Leu Ile Lys Tyr Asp Leu Gln Asn 
        435                 440                 445             
Leu Lys Pro Tyr Thr Lys Tyr Val Leu Ser Leu His Ala Tyr Ile Ile 
    450                 455                 460                 
Ala Lys Val Gln Arg Asn Gly Ser Ala Ala Met Cys His Phe Thr Thr 
465                 470                 475                 480 
Lys Ser Ala Pro Pro Ser Gln Val Trp Asn Met Thr Val Ser Met Thr 
                485                 490                 495     
Ser Asp Asn Ser Met His Val Lys Cys Arg Pro Pro Arg Asp Arg Asn 
            500                 505                 510         
Gly Pro His Glu Arg Tyr His Leu Glu Val Glu Ala Gly Asn Thr Leu 
        515                 520                 525             
Val Arg Asn Glu Ser His Lys Asn Cys Asp Phe Arg Val Lys Asp Leu 
    530                 535                 540                 
Gln Tyr Ser Thr Asp Tyr Thr Phe Lys Ala Tyr Phe His Asn Gly Asp 
545                 550                 555                 560 
Tyr Pro Gly Glu Pro Phe Ile Leu His His Ser Thr Ser Tyr Asn Ser 
                565                 570                 575     
Lys Ala Leu Ile Ala Phe Leu Ala Phe Leu Ile Ile Val Thr Ser Ile 
            580                 585                 590         
Ala Leu Leu Val Val Leu Tyr Lys Ile Tyr Asp Leu His Lys Lys Arg 
        595                 600                 605             
Ser Cys Asn Leu Asp Glu Gln Gln Glu Leu Val Glu Arg Asp Asp Glu 
    610                 615                 620                 
Lys Gln Leu Met Asn Val Glu Pro Ile His Ala Asp Ile Leu Leu Glu 
625                 630                 635                 640 
Thr Tyr Lys Arg Lys Ile Ala Asp Glu Gly Arg Leu Phe Leu Ala Glu 
                645                 650                 655     
Phe Gln Ser Ile Pro Arg Val Phe Ser Lys Phe Pro Ile Lys Glu Ala 
            660                 665                 670         
Arg Lys Pro Phe Asn Gln Asn Lys Asn Arg Tyr Val Asp Ile Leu Pro 
        675                 680                 685             
Tyr Asp Tyr Asn Arg Val Glu Leu Ser Glu Ile Asn Gly Asp Ala Gly 
    690                 695                 700                 
Ser Asn Tyr Ile Asn Ala Ser Tyr Ile Asp Gly Phe Lys Glu Pro Arg 
705                 710                 715                 720 
Lys Tyr Ile Ala Ala Gln Gly Pro Arg Asp Glu Thr Val Asp Asp Phe 
                725                 730                 735     
Trp Arg Met Ile Trp Glu Gln Lys Ala Thr Val Ile Val Met Val Thr 
            740                 745                 750         
Arg Cys Glu Glu Gly Asn Arg Asn Lys Cys Ala Glu Tyr Trp Pro Ser 
        755                 760                 765             
Met Glu Glu Gly Thr Arg Ala Phe Gly Asp Val Val Val Lys Ile Asn 
    770                 775                 780                 
Gln His Lys Arg Cys Pro Asp Tyr Ile Ile Gln Lys Leu Asn Ile Val 
785                 790                 795                 800 
Asn Lys Lys Glu Lys Ala Thr Gly Arg Glu Val Thr His Ile Gln Phe 
                805                 810                 815     
Thr Ser Trp Pro Asp His Gly Val Pro Glu Asp Pro His Leu Leu Leu 
            820                 825                 830         
Lys Leu Arg Arg Arg Val Asn Ala Phe Ser Asn Phe Phe Ser Gly Pro 
        835                 840                 845             
Ile Val Val His Cys Ser Ala Gly Val Gly Arg Thr Gly Thr Tyr Ile 
    850                 855                 860                 
Gly Ile Asp Ala Met Leu Glu Gly Leu Glu Ala Glu Asn Lys Val Asp 
865                 870                 875                 880 
Val Tyr Gly Tyr Val Val Lys Leu Arg Arg Gln Arg Cys Leu Met Val 
                885                 890                 895     
Gln Val Glu Ala Gln Tyr Ile Leu Ile His Gln Ala Leu Val Glu Tyr 
            900                 905                 910         
Asn Gln Phe Gly Glu Thr Glu Val Asn Leu Ser Glu Leu His Pro Tyr 
        915                 920                 925             
Leu His Asn Met Lys Lys Arg Asp Pro Pro Ser Glu Pro Ser Pro Leu 
    930                 935                 940                 
Glu Ala Glu Phe Gln Arg Leu Pro Ser Tyr Arg Ser Trp Arg Thr Gln 
945                 950                 955                 960 
His Ile Gly Asn Gln Glu Glu Asn Lys Ser Lys Asn Arg Asn Ser Asn 
                965                 970                 975     
Val Ile Pro Tyr Asp Tyr Asn Arg Val Pro Leu Lys His Glu Leu Glu 
            980                 985                 990         
Met Ser Lys Glu Ser Glu His Asp Ser Asp Glu Ser Ser Asp Asp Asp 
        995                 1000                1005            
Ser Asp Ser Glu Glu Pro Ser Lys Tyr Ile Asn Ala Ser Phe Ile Met 
    1010                1015                1020                
Ser Tyr Trp Lys Pro Glu Val Met Ile Ala Ala Gln Gly Pro Leu Lys 
1025                1030                1035                1040
Glu Thr Ile Gly Asp Phe Trp Gln Met Ile Phe Gln Arg Lys Val Lys 
                1045                1050                1055    
Val Ile Val Met Leu Thr Glu Leu Lys His Gly Asp Gln Glu Ile Cys 
            1060                1065                1070        
Ala Gln Tyr Trp Gly Glu Gly Lys Gln Thr Tyr Gly Asp Ile Glu Val 
        1075                1080                1085            
Asp Leu Lys Asp Thr Asp Lys Ser Ser Thr Tyr Thr Leu Arg Val Phe 
    1090                1095                1100                
Glu Leu Arg His Ser Lys Arg Lys Asp Ser Arg Thr Val Tyr Gln Tyr 
1105                1110                1115                1120
Gln Tyr Thr Asn Trp Ser Val Glu Gln Leu Pro Ala Glu Pro Lys Glu 
                1125                1130                1135    
Leu Ile Ser Met Ile Gln Val Val Lys Gln Lys Leu Pro Gln Lys Asn 
            1140                1145                1150        
Ser Ser Glu Gly Asn Lys His His Lys Ser Thr Pro Leu Leu Ile His 
        1155                1160                1165            
Cys Arg Asp Gly Ser Gln Gln Thr Gly Ile Phe Cys Ala Leu Leu Asn 
    1170                1175                1180                
Leu Leu Glu Ser Ala Glu Thr Glu Glu Val Val Asp Ile Phe Gln Val 
1185                1190                1195                1200
Val Lys Ala Leu Arg Lys Ala Arg Pro Gly Met Val Ser Thr Phe Glu 
                1205                1210                1215    
Gln Tyr Gln Phe Leu Tyr Asp Val Ile Ala Ser Thr Tyr Pro Ala Gln 
            1220                1225                1230        
Asn Gly Gln Val Lys Lys Asn Asn His Gln Glu Asp Lys Ile Glu Phe 
        1235                1240                1245            
Asp Asn Glu Val Asp Lys Val Lys Gln Asp Ala Asn Cys Val Asn Pro 
    1250                1255                1260                
Leu Gly Ala Pro Glu Lys Leu Pro Glu Ala Lys Glu Gln Ala Glu Gly 
1265                1270                1275                1280
Ser Glu Pro Thr Ser Gly Thr Glu Gly Pro Glu His Ser Val Asn Gly 
                1285                1290                1295    
Pro Ala Ser Pro Ala Leu Asn Gln Gly Ser 
            1300                1305    

<210> 100
<211> 17
<212> PRT
<213> Artificial Sequence


<220> 
<223> VH-CDR2

<400> 100
Asp Ile Phe Pro Gly Gly Asp Tyr Thr Asn Tyr Ala Glu Lys Phe Gln 
1               5                   10                  15      
Gly 
    

<210> 101
<211> 114
<212> PRT
<213> Artificial Sequence


<220> 
<223> Humanized HCVR

<400> 101
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      
Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asn Tyr 
            20                  25                  30          
Tyr Ile Gly Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              
Gly Asp Ile Phe Pro Gly Gly Asp Tyr Thr Asn Tyr Ala Glu Lys Phe 
    50                  55                  60                  
Gln Gly Arg Val Thr Leu Thr Ala Asp Thr Ser Ile Ser Thr Ala Tyr 
65                  70                  75                  80  
Met Glu Leu Ser Arg Leu Arg Ser Asp Asp Thr Val Val Tyr Tyr Cys 
                85                  90                  95      
Val Arg Arg Asn Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val 
            100                 105                 110         
Ser Ser 
        

<210> 102
<211> 107
<212> PRT
<213> Artificial Sequence


<220> 
<223> Humanized LCVR

<220> 
<221> SITE
<222> 31
<223> Xaa is selected from Asn (N), Ser (S) and Gly (G)

<400> 102
Asp Ile Gln Leu Thr Gln Ser Pro Ser Phe Leu Ser Ala Ser Val Gly 
1               5                   10                  15      
Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Ser Ser Val Ser Xaa Tyr 
            20                  25                  30          
Met His Trp Phe Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Trp Ile 
        35                  40                  45              
Tyr Asn Thr Ser Asn Leu Pro Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  
Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  
Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Arg Ser Ser Tyr Pro Leu 
                85                  90                  95      
Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105         

<210> 103
<211> 107
<212> PRT
<213> Artificial Sequence


<220> 
<223> Humanized LCVR

<400> 103
Asp Ile Gln Leu Thr Gln Ser Pro Ser Phe Leu Ser Ala Ser Val Gly 
1               5                   10                  15      
Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Ser Ser Val Ser Ser Tyr 
            20                  25                  30          
Met His Trp Phe Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Trp Ile 
        35                  40                  45              
Tyr Asn Thr Ser Asn Leu Pro Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  
Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  
Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Arg Ser Ser Tyr Pro Leu 
                85                  90                  95      
Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105         

<210> 104
<211> 1193
<212> PRT
<213> Homo sapiens


<220> 
<223> hCD45RC

<300> 
<308> UniProt Accession P08575-10
<309> 2018 03 28

<400> 104
Met Thr Met Tyr Leu Trp Leu Lys Leu Leu Ala Phe Gly Phe Ala Phe 
1               5                   10                  15      
Leu Asp Thr Glu Val Phe Val Thr Gly Gln Ser Pro Thr Pro Ser Pro 
            20                  25                  30          
Thr Asp Val Pro Gly Glu Arg Ser Thr Ala Ser Thr Phe Pro Thr Asp 
        35                  40                  45              
Pro Val Ser Pro Leu Thr Thr Thr Leu Ser Leu Ala His His Ser Ser 
    50                  55                  60                  
Ala Ala Leu Pro Ala Arg Thr Ser Asn Thr Thr Ile Thr Ala Asn Thr 
65                  70                  75                  80  
Ser Asp Ala Tyr Leu Asn Ala Ser Glu Thr Thr Thr Leu Ser Pro Ser 
                85                  90                  95      
Gly Ser Ala Val Ile Ser Thr Thr Thr Ile Ala Thr Thr Pro Ser Lys 
            100                 105                 110         
Pro Thr Cys Asp Glu Lys Tyr Ala Asn Ile Thr Val Asp Tyr Leu Tyr 
        115                 120                 125             
Asn Lys Glu Thr Lys Leu Phe Thr Ala Lys Leu Asn Val Asn Glu Asn 
    130                 135                 140                 
Val Glu Cys Gly Asn Asn Thr Cys Thr Asn Asn Glu Val His Asn Leu 
145                 150                 155                 160 
Thr Glu Cys Lys Asn Ala Ser Val Ser Ile Ser His Asn Ser Cys Thr 
                165                 170                 175     
Ala Pro Asp Lys Thr Leu Ile Leu Asp Val Pro Pro Gly Val Glu Lys 
            180                 185                 190         
Phe Gln Leu His Asp Cys Thr Gln Val Glu Lys Ala Asp Thr Thr Ile 
        195                 200                 205             
Cys Leu Lys Trp Lys Asn Ile Glu Thr Phe Thr Cys Asp Thr Gln Asn 
    210                 215                 220                 
Ile Thr Tyr Arg Phe Gln Cys Gly Asn Met Ile Phe Asp Asn Lys Glu 
225                 230                 235                 240 
Ile Lys Leu Glu Asn Leu Glu Pro Glu His Glu Tyr Lys Cys Asp Ser 
                245                 250                 255     
Glu Ile Leu Tyr Asn Asn His Lys Phe Thr Asn Ala Ser Lys Ile Ile 
            260                 265                 270         
Lys Thr Asp Phe Gly Ser Pro Gly Glu Pro Gln Ile Ile Phe Cys Arg 
        275                 280                 285             
Ser Glu Ala Ala His Gln Gly Val Ile Thr Trp Asn Pro Pro Gln Arg 
    290                 295                 300                 
Ser Phe His Asn Phe Thr Leu Cys Tyr Ile Lys Glu Thr Glu Lys Asp 
305                 310                 315                 320 
Cys Leu Asn Leu Asp Lys Asn Leu Ile Lys Tyr Asp Leu Gln Asn Leu 
                325                 330                 335     
Lys Pro Tyr Thr Lys Tyr Val Leu Ser Leu His Ala Tyr Ile Ile Ala 
            340                 345                 350         
Lys Val Gln Arg Asn Gly Ser Ala Ala Met Cys His Phe Thr Thr Lys 
        355                 360                 365             
Ser Ala Pro Pro Ser Gln Val Trp Asn Met Thr Val Ser Met Thr Ser 
    370                 375                 380                 
Asp Asn Ser Met His Val Lys Cys Arg Pro Pro Arg Asp Arg Asn Gly 
385                 390                 395                 400 
Pro His Glu Arg Tyr His Leu Glu Val Glu Ala Gly Asn Thr Leu Val 
                405                 410                 415     
Arg Asn Glu Ser His Lys Asn Cys Asp Phe Arg Val Lys Asp Leu Gln 
            420                 425                 430         
Tyr Ser Thr Asp Tyr Thr Phe Lys Ala Tyr Phe His Asn Gly Asp Tyr 
        435                 440                 445             
Pro Gly Glu Pro Phe Ile Leu His His Ser Thr Ser Tyr Asn Ser Lys 
    450                 455                 460                 
Ala Leu Ile Ala Phe Leu Ala Phe Leu Ile Ile Val Thr Ser Ile Ala 
465                 470                 475                 480 
Leu Leu Val Val Leu Tyr Lys Ile Tyr Asp Leu His Lys Lys Arg Ser 
                485                 490                 495     
Cys Asn Leu Asp Glu Gln Gln Glu Leu Val Glu Arg Asp Asp Glu Lys 
            500                 505                 510         
Gln Leu Met Asn Val Glu Pro Ile His Ala Asp Ile Leu Leu Glu Thr 
        515                 520                 525             
Tyr Lys Arg Lys Ile Ala Asp Glu Gly Arg Leu Phe Leu Ala Glu Phe 
    530                 535                 540                 
Gln Ser Ile Pro Arg Val Phe Ser Lys Phe Pro Ile Lys Glu Ala Arg 
545                 550                 555                 560 
Lys Pro Phe Asn Gln Asn Lys Asn Arg Tyr Val Asp Ile Leu Pro Tyr 
                565                 570                 575     
Asp Tyr Asn Arg Val Glu Leu Ser Glu Ile Asn Gly Asp Ala Gly Ser 
            580                 585                 590         
Asn Tyr Ile Asn Ala Ser Tyr Ile Asp Gly Phe Lys Glu Pro Arg Lys 
        595                 600                 605             
Tyr Ile Ala Ala Gln Gly Pro Arg Asp Glu Thr Val Asp Asp Phe Trp 
    610                 615                 620                 
Arg Met Ile Trp Glu Gln Lys Ala Thr Val Ile Val Met Val Thr Arg 
625                 630                 635                 640 
Cys Glu Glu Gly Asn Arg Asn Lys Cys Ala Glu Tyr Trp Pro Ser Met 
                645                 650                 655     
Glu Glu Gly Thr Arg Ala Phe Gly Asp Val Val Val Lys Ile Asn Gln 
            660                 665                 670         
His Lys Arg Cys Pro Asp Tyr Ile Ile Gln Lys Leu Asn Ile Val Asn 
        675                 680                 685             
Lys Lys Glu Lys Ala Thr Gly Arg Glu Val Thr His Ile Gln Phe Thr 
    690                 695                 700                 
Ser Trp Pro Asp His Gly Val Pro Glu Asp Pro His Leu Leu Leu Lys 
705                 710                 715                 720 
Leu Arg Arg Arg Val Asn Ala Phe Ser Asn Phe Phe Ser Gly Pro Ile 
                725                 730                 735     
Val Val His Cys Ser Ala Gly Val Gly Arg Thr Gly Thr Tyr Ile Gly 
            740                 745                 750         
Ile Asp Ala Met Leu Glu Gly Leu Glu Ala Glu Asn Lys Val Asp Val 
        755                 760                 765             
Tyr Gly Tyr Val Val Lys Leu Arg Arg Gln Arg Cys Leu Met Val Gln 
    770                 775                 780                 
Val Glu Ala Gln Tyr Ile Leu Ile His Gln Ala Leu Val Glu Tyr Asn 
785                 790                 795                 800 
Gln Phe Gly Glu Thr Glu Val Asn Leu Ser Glu Leu His Pro Tyr Leu 
                805                 810                 815     
His Asn Met Lys Lys Arg Asp Pro Pro Ser Glu Pro Ser Pro Leu Glu 
            820                 825                 830         
Ala Glu Phe Gln Arg Leu Pro Ser Tyr Arg Ser Trp Arg Thr Gln His 
        835                 840                 845             
Ile Gly Asn Gln Glu Glu Asn Lys Ser Lys Asn Arg Asn Ser Asn Val 
    850                 855                 860                 
Ile Pro Tyr Asp Tyr Asn Arg Val Pro Leu Lys His Glu Leu Glu Met 
865                 870                 875                 880 
Ser Lys Glu Ser Glu His Asp Ser Asp Glu Ser Ser Asp Asp Asp Ser 
                885                 890                 895     
Asp Ser Glu Glu Pro Ser Lys Tyr Ile Asn Ala Ser Phe Ile Met Ser 
            900                 905                 910         
Tyr Trp Lys Pro Glu Val Met Ile Ala Ala Gln Gly Pro Leu Lys Glu 
        915                 920                 925             
Thr Ile Gly Asp Phe Trp Gln Met Ile Phe Gln Arg Lys Val Lys Val 
    930                 935                 940                 
Ile Val Met Leu Thr Glu Leu Lys His Gly Asp Gln Glu Ile Cys Ala 
945                 950                 955                 960 
Gln Tyr Trp Gly Glu Gly Lys Gln Thr Tyr Gly Asp Ile Glu Val Asp 
                965                 970                 975     
Leu Lys Asp Thr Asp Lys Ser Ser Thr Tyr Thr Leu Arg Val Phe Glu 
            980                 985                 990         
Leu Arg His Ser Lys Arg Lys Asp Ser Arg Thr Val Tyr Gln Tyr Gln 
        995                 1000                1005            
Tyr Thr Asn Trp Ser Val Glu Gln Leu Pro Ala Glu Pro Lys Glu Leu 
    1010                1015                1020                
Ile Ser Met Ile Gln Val Val Lys Gln Lys Leu Pro Gln Lys Asn Ser 
1025                1030                1035                1040
Ser Glu Gly Asn Lys His His Lys Ser Thr Pro Leu Leu Ile His Cys 
                1045                1050                1055    
Arg Asp Gly Ser Gln Gln Thr Gly Ile Phe Cys Ala Leu Leu Asn Leu 
            1060                1065                1070        
Leu Glu Ser Ala Glu Thr Glu Glu Val Val Asp Ile Phe Gln Val Val 
        1075                1080                1085            
Lys Ala Leu Arg Lys Ala Arg Pro Gly Met Val Ser Thr Phe Glu Gln 
    1090                1095                1100                
Tyr Gln Phe Leu Tyr Asp Val Ile Ala Ser Thr Tyr Pro Ala Gln Asn 
1105                1110                1115                1120
Gly Gln Val Lys Lys Asn Asn His Gln Glu Asp Lys Ile Glu Phe Asp 
                1125                1130                1135    
Asn Glu Val Asp Lys Val Lys Gln Asp Ala Asn Cys Val Asn Pro Leu 
            1140                1145                1150        
Gly Ala Pro Glu Lys Leu Pro Glu Ala Lys Glu Gln Ala Glu Gly Ser 
        1155                1160                1165            
Glu Pro Thr Ser Gly Thr Glu Gly Pro Glu His Ser Val Asn Gly Pro 
    1170                1175                1180                
Ala Ser Pro Ala Leu Asn Gln Gly Ser 
1185                1190            

<210> 105
<211> 66
<212> PRT
<213> Homo sapiens


<220> 
<223> A determinant of hCD45

<400> 105
Gly Leu Thr Thr Ala Lys Met Pro Ser Val Pro Leu Ser Ser Asp Pro 
1               5                   10                  15      
Leu Pro Thr His Thr Thr Ala Phe Ser Pro Ala Ser Thr Phe Glu Arg 
            20                  25                  30          
Glu Asn Asp Phe Ser Glu Thr Thr Thr Ser Leu Ser Pro Asp Asn Thr 
        35                  40                  45              
Ser Thr Gln Val Ser Pro Asp Ser Leu Asp Asn Ala Ser Ala Phe Asn 
    50                  55                  60                  
Thr Thr 
65      

<210> 106
<211> 47
<212> PRT
<213> Homo sapiens


<220> 
<223> B determinant of hCD45

<400> 106
Gly Val Ser Ser Val Gln Thr Pro His Leu Pro Thr His Ala Asp Ser 
1               5                   10                  15      
Gln Thr Pro Ser Ala Gly Thr Asp Thr Gln Thr Phe Ser Gly Ser Ala 
            20                  25                  30          
Ala Asn Ala Lys Leu Asn Pro Thr Pro Gly Ser Asn Ala Ile Ser 
        35                  40                  45          

<210> 107
<211> 1211
<212> PRT
<213> Homo sapiens


<220> 
<223> hCD45RA

<300> 
<308> UniProt Accession P08575-8
<309> 2018 03 28

<400> 107
Met Thr Met Tyr Leu Trp Leu Lys Leu Leu Ala Phe Gly Phe Ala Phe 
1               5                   10                  15      
Leu Asp Thr Glu Val Phe Val Thr Gly Gln Ser Pro Thr Pro Ser Pro 
            20                  25                  30          
Thr Gly Leu Thr Thr Ala Lys Met Pro Ser Val Pro Leu Ser Ser Asp 
        35                  40                  45              
Pro Leu Pro Thr His Thr Thr Ala Phe Ser Pro Ala Ser Thr Phe Glu 
    50                  55                  60                  
Arg Glu Asn Asp Phe Ser Glu Thr Thr Thr Ser Leu Ser Pro Asp Asn 
65                  70                  75                  80  
Thr Ser Thr Gln Val Ser Pro Asp Ser Leu Asp Asn Ala Ser Ala Phe 
                85                  90                  95      
Asn Thr Thr Asp Ala Tyr Leu Asn Ala Ser Glu Thr Thr Thr Leu Ser 
            100                 105                 110         
Pro Ser Gly Ser Ala Val Ile Ser Thr Thr Thr Ile Ala Thr Thr Pro 
        115                 120                 125             
Ser Lys Pro Thr Cys Asp Glu Lys Tyr Ala Asn Ile Thr Val Asp Tyr 
    130                 135                 140                 
Leu Tyr Asn Lys Glu Thr Lys Leu Phe Thr Ala Lys Leu Asn Val Asn 
145                 150                 155                 160 
Glu Asn Val Glu Cys Gly Asn Asn Thr Cys Thr Asn Asn Glu Val His 
                165                 170                 175     
Asn Leu Thr Glu Cys Lys Asn Ala Ser Val Ser Ile Ser His Asn Ser 
            180                 185                 190         
Cys Thr Ala Pro Asp Lys Thr Leu Ile Leu Asp Val Pro Pro Gly Val 
        195                 200                 205             
Glu Lys Phe Gln Leu His Asp Cys Thr Gln Val Glu Lys Ala Asp Thr 
    210                 215                 220                 
Thr Ile Cys Leu Lys Trp Lys Asn Ile Glu Thr Phe Thr Cys Asp Thr 
225                 230                 235                 240 
Gln Asn Ile Thr Tyr Arg Phe Gln Cys Gly Asn Met Ile Phe Asp Asn 
                245                 250                 255     
Lys Glu Ile Lys Leu Glu Asn Leu Glu Pro Glu His Glu Tyr Lys Cys 
            260                 265                 270         
Asp Ser Glu Ile Leu Tyr Asn Asn His Lys Phe Thr Asn Ala Ser Lys 
        275                 280                 285             
Ile Ile Lys Thr Asp Phe Gly Ser Pro Gly Glu Pro Gln Ile Ile Phe 
    290                 295                 300                 
Cys Arg Ser Glu Ala Ala His Gln Gly Val Ile Thr Trp Asn Pro Pro 
305                 310                 315                 320 
Gln Arg Ser Phe His Asn Phe Thr Leu Cys Tyr Ile Lys Glu Thr Glu 
                325                 330                 335     
Lys Asp Cys Leu Asn Leu Asp Lys Asn Leu Ile Lys Tyr Asp Leu Gln 
            340                 345                 350         
Asn Leu Lys Pro Tyr Thr Lys Tyr Val Leu Ser Leu His Ala Tyr Ile 
        355                 360                 365             
Ile Ala Lys Val Gln Arg Asn Gly Ser Ala Ala Met Cys His Phe Thr 
    370                 375                 380                 
Thr Lys Ser Ala Pro Pro Ser Gln Val Trp Asn Met Thr Val Ser Met 
385                 390                 395                 400 
Thr Ser Asp Asn Ser Met His Val Lys Cys Arg Pro Pro Arg Asp Arg 
                405                 410                 415     
Asn Gly Pro His Glu Arg Tyr His Leu Glu Val Glu Ala Gly Asn Thr 
            420                 425                 430         
Leu Val Arg Asn Glu Ser His Lys Asn Cys Asp Phe Arg Val Lys Asp 
        435                 440                 445             
Leu Gln Tyr Ser Thr Asp Tyr Thr Phe Lys Ala Tyr Phe His Asn Gly 
    450                 455                 460                 
Asp Tyr Pro Gly Glu Pro Phe Ile Leu His His Ser Thr Ser Tyr Asn 
465                 470                 475                 480 
Ser Lys Ala Leu Ile Ala Phe Leu Ala Phe Leu Ile Ile Val Thr Ser 
                485                 490                 495     
Ile Ala Leu Leu Val Val Leu Tyr Lys Ile Tyr Asp Leu His Lys Lys 
            500                 505                 510         
Arg Ser Cys Asn Leu Asp Glu Gln Gln Glu Leu Val Glu Arg Asp Asp 
        515                 520                 525             
Glu Lys Gln Leu Met Asn Val Glu Pro Ile His Ala Asp Ile Leu Leu 
    530                 535                 540                 
Glu Thr Tyr Lys Arg Lys Ile Ala Asp Glu Gly Arg Leu Phe Leu Ala 
545                 550                 555                 560 
Glu Phe Gln Ser Ile Pro Arg Val Phe Ser Lys Phe Pro Ile Lys Glu 
                565                 570                 575     
Ala Arg Lys Pro Phe Asn Gln Asn Lys Asn Arg Tyr Val Asp Ile Leu 
            580                 585                 590         
Pro Tyr Asp Tyr Asn Arg Val Glu Leu Ser Glu Ile Asn Gly Asp Ala 
        595                 600                 605             
Gly Ser Asn Tyr Ile Asn Ala Ser Tyr Ile Asp Gly Phe Lys Glu Pro 
    610                 615                 620                 
Arg Lys Tyr Ile Ala Ala Gln Gly Pro Arg Asp Glu Thr Val Asp Asp 
625                 630                 635                 640 
Phe Trp Arg Met Ile Trp Glu Gln Lys Ala Thr Val Ile Val Met Val 
                645                 650                 655     
Thr Arg Cys Glu Glu Gly Asn Arg Asn Lys Cys Ala Glu Tyr Trp Pro 
            660                 665                 670         
Ser Met Glu Glu Gly Thr Arg Ala Phe Gly Asp Val Val Val Lys Ile 
        675                 680                 685             
Asn Gln His Lys Arg Cys Pro Asp Tyr Ile Ile Gln Lys Leu Asn Ile 
    690                 695                 700                 
Val Asn Lys Lys Glu Lys Ala Thr Gly Arg Glu Val Thr His Ile Gln 
705                 710                 715                 720 
Phe Thr Ser Trp Pro Asp His Gly Val Pro Glu Asp Pro His Leu Leu 
                725                 730                 735     
Leu Lys Leu Arg Arg Arg Val Asn Ala Phe Ser Asn Phe Phe Ser Gly 
            740                 745                 750         
Pro Ile Val Val His Cys Ser Ala Gly Val Gly Arg Thr Gly Thr Tyr 
        755                 760                 765             
Ile Gly Ile Asp Ala Met Leu Glu Gly Leu Glu Ala Glu Asn Lys Val 
    770                 775                 780                 
Asp Val Tyr Gly Tyr Val Val Lys Leu Arg Arg Gln Arg Cys Leu Met 
785                 790                 795                 800 
Val Gln Val Glu Ala Gln Tyr Ile Leu Ile His Gln Ala Leu Val Glu 
                805                 810                 815     
Tyr Asn Gln Phe Gly Glu Thr Glu Val Asn Leu Ser Glu Leu His Pro 
            820                 825                 830         
Tyr Leu His Asn Met Lys Lys Arg Asp Pro Pro Ser Glu Pro Ser Pro 
        835                 840                 845             
Leu Glu Ala Glu Phe Gln Arg Leu Pro Ser Tyr Arg Ser Trp Arg Thr 
    850                 855                 860                 
Gln His Ile Gly Asn Gln Glu Glu Asn Lys Ser Lys Asn Arg Asn Ser 
865                 870                 875                 880 
Asn Val Ile Pro Tyr Asp Tyr Asn Arg Val Pro Leu Lys His Glu Leu 
                885                 890                 895     
Glu Met Ser Lys Glu Ser Glu His Asp Ser Asp Glu Ser Ser Asp Asp 
            900                 905                 910         
Asp Ser Asp Ser Glu Glu Pro Ser Lys Tyr Ile Asn Ala Ser Phe Ile 
        915                 920                 925             
Met Ser Tyr Trp Lys Pro Glu Val Met Ile Ala Ala Gln Gly Pro Leu 
    930                 935                 940                 
Lys Glu Thr Ile Gly Asp Phe Trp Gln Met Ile Phe Gln Arg Lys Val 
945                 950                 955                 960 
Lys Val Ile Val Met Leu Thr Glu Leu Lys His Gly Asp Gln Glu Ile 
                965                 970                 975     
Cys Ala Gln Tyr Trp Gly Glu Gly Lys Gln Thr Tyr Gly Asp Ile Glu 
            980                 985                 990         
Val Asp Leu Lys Asp Thr Asp Lys Ser Ser Thr Tyr Thr Leu Arg Val 
        995                 1000                1005            
Phe Glu Leu Arg His Ser Lys Arg Lys Asp Ser Arg Thr Val Tyr Gln 
    1010                1015                1020                
Tyr Gln Tyr Thr Asn Trp Ser Val Glu Gln Leu Pro Ala Glu Pro Lys 
1025                1030                1035                1040
Glu Leu Ile Ser Met Ile Gln Val Val Lys Gln Lys Leu Pro Gln Lys 
                1045                1050                1055    
Asn Ser Ser Glu Gly Asn Lys His His Lys Ser Thr Pro Leu Leu Ile 
            1060                1065                1070        
His Cys Arg Asp Gly Ser Gln Gln Thr Gly Ile Phe Cys Ala Leu Leu 
        1075                1080                1085            
Asn Leu Leu Glu Ser Ala Glu Thr Glu Glu Val Val Asp Ile Phe Gln 
    1090                1095                1100                
Val Val Lys Ala Leu Arg Lys Ala Arg Pro Gly Met Val Ser Thr Phe 
1105                1110                1115                1120
Glu Gln Tyr Gln Phe Leu Tyr Asp Val Ile Ala Ser Thr Tyr Pro Ala 
                1125                1130                1135    
Gln Asn Gly Gln Val Lys Lys Asn Asn His Gln Glu Asp Lys Ile Glu 
            1140                1145                1150        
Phe Asp Asn Glu Val Asp Lys Val Lys Gln Asp Ala Asn Cys Val Asn 
        1155                1160                1165            
Pro Leu Gly Ala Pro Glu Lys Leu Pro Glu Ala Lys Glu Gln Ala Glu 
    1170                1175                1180                
Gly Ser Glu Pro Thr Ser Gly Thr Glu Gly Pro Glu His Ser Val Asn 
1185                1190                1195                1200
Gly Pro Ala Ser Pro Ala Leu Asn Gln Gly Ser 
                1205                1210    

<210> 108
<211> 1192
<212> PRT
<213> Homo sapiens


<220> 
<223> hCD45RB

<300> 
<308> UniProt Accession P08575-9
<309> 2018 03 28

<400> 108
Met Thr Met Tyr Leu Trp Leu Lys Leu Leu Ala Phe Gly Phe Ala Phe 
1               5                   10                  15      
Leu Asp Thr Glu Val Phe Val Thr Gly Gln Ser Pro Thr Pro Ser Pro 
            20                  25                  30          
Thr Gly Val Ser Ser Val Gln Thr Pro His Leu Pro Thr His Ala Asp 
        35                  40                  45              
Ser Gln Thr Pro Ser Ala Gly Thr Asp Thr Gln Thr Phe Ser Gly Ser 
    50                  55                  60                  
Ala Ala Asn Ala Lys Leu Asn Pro Thr Pro Gly Ser Asn Ala Ile Ser 
65                  70                  75                  80  
Asp Ala Tyr Leu Asn Ala Ser Glu Thr Thr Thr Leu Ser Pro Ser Gly 
                85                  90                  95      
Ser Ala Val Ile Ser Thr Thr Thr Ile Ala Thr Thr Pro Ser Lys Pro 
            100                 105                 110         
Thr Cys Asp Glu Lys Tyr Ala Asn Ile Thr Val Asp Tyr Leu Tyr Asn 
        115                 120                 125             
Lys Glu Thr Lys Leu Phe Thr Ala Lys Leu Asn Val Asn Glu Asn Val 
    130                 135                 140                 
Glu Cys Gly Asn Asn Thr Cys Thr Asn Asn Glu Val His Asn Leu Thr 
145                 150                 155                 160 
Glu Cys Lys Asn Ala Ser Val Ser Ile Ser His Asn Ser Cys Thr Ala 
                165                 170                 175     
Pro Asp Lys Thr Leu Ile Leu Asp Val Pro Pro Gly Val Glu Lys Phe 
            180                 185                 190         
Gln Leu His Asp Cys Thr Gln Val Glu Lys Ala Asp Thr Thr Ile Cys 
        195                 200                 205             
Leu Lys Trp Lys Asn Ile Glu Thr Phe Thr Cys Asp Thr Gln Asn Ile 
    210                 215                 220                 
Thr Tyr Arg Phe Gln Cys Gly Asn Met Ile Phe Asp Asn Lys Glu Ile 
225                 230                 235                 240 
Lys Leu Glu Asn Leu Glu Pro Glu His Glu Tyr Lys Cys Asp Ser Glu 
                245                 250                 255     
Ile Leu Tyr Asn Asn His Lys Phe Thr Asn Ala Ser Lys Ile Ile Lys 
            260                 265                 270         
Thr Asp Phe Gly Ser Pro Gly Glu Pro Gln Ile Ile Phe Cys Arg Ser 
        275                 280                 285             
Glu Ala Ala His Gln Gly Val Ile Thr Trp Asn Pro Pro Gln Arg Ser 
    290                 295                 300                 
Phe His Asn Phe Thr Leu Cys Tyr Ile Lys Glu Thr Glu Lys Asp Cys 
305                 310                 315                 320 
Leu Asn Leu Asp Lys Asn Leu Ile Lys Tyr Asp Leu Gln Asn Leu Lys 
                325                 330                 335     
Pro Tyr Thr Lys Tyr Val Leu Ser Leu His Ala Tyr Ile Ile Ala Lys 
            340                 345                 350         
Val Gln Arg Asn Gly Ser Ala Ala Met Cys His Phe Thr Thr Lys Ser 
        355                 360                 365             
Ala Pro Pro Ser Gln Val Trp Asn Met Thr Val Ser Met Thr Ser Asp 
    370                 375                 380                 
Asn Ser Met His Val Lys Cys Arg Pro Pro Arg Asp Arg Asn Gly Pro 
385                 390                 395                 400 
His Glu Arg Tyr His Leu Glu Val Glu Ala Gly Asn Thr Leu Val Arg 
                405                 410                 415     
Asn Glu Ser His Lys Asn Cys Asp Phe Arg Val Lys Asp Leu Gln Tyr 
            420                 425                 430         
Ser Thr Asp Tyr Thr Phe Lys Ala Tyr Phe His Asn Gly Asp Tyr Pro 
        435                 440                 445             
Gly Glu Pro Phe Ile Leu His His Ser Thr Ser Tyr Asn Ser Lys Ala 
    450                 455                 460                 
Leu Ile Ala Phe Leu Ala Phe Leu Ile Ile Val Thr Ser Ile Ala Leu 
465                 470                 475                 480 
Leu Val Val Leu Tyr Lys Ile Tyr Asp Leu His Lys Lys Arg Ser Cys 
                485                 490                 495     
Asn Leu Asp Glu Gln Gln Glu Leu Val Glu Arg Asp Asp Glu Lys Gln 
            500                 505                 510         
Leu Met Asn Val Glu Pro Ile His Ala Asp Ile Leu Leu Glu Thr Tyr 
        515                 520                 525             
Lys Arg Lys Ile Ala Asp Glu Gly Arg Leu Phe Leu Ala Glu Phe Gln 
    530                 535                 540                 
Ser Ile Pro Arg Val Phe Ser Lys Phe Pro Ile Lys Glu Ala Arg Lys 
545                 550                 555                 560 
Pro Phe Asn Gln Asn Lys Asn Arg Tyr Val Asp Ile Leu Pro Tyr Asp 
                565                 570                 575     
Tyr Asn Arg Val Glu Leu Ser Glu Ile Asn Gly Asp Ala Gly Ser Asn 
            580                 585                 590         
Tyr Ile Asn Ala Ser Tyr Ile Asp Gly Phe Lys Glu Pro Arg Lys Tyr 
        595                 600                 605             
Ile Ala Ala Gln Gly Pro Arg Asp Glu Thr Val Asp Asp Phe Trp Arg 
    610                 615                 620                 
Met Ile Trp Glu Gln Lys Ala Thr Val Ile Val Met Val Thr Arg Cys 
625                 630                 635                 640 
Glu Glu Gly Asn Arg Asn Lys Cys Ala Glu Tyr Trp Pro Ser Met Glu 
                645                 650                 655     
Glu Gly Thr Arg Ala Phe Gly Asp Val Val Val Lys Ile Asn Gln His 
            660                 665                 670         
Lys Arg Cys Pro Asp Tyr Ile Ile Gln Lys Leu Asn Ile Val Asn Lys 
        675                 680                 685             
Lys Glu Lys Ala Thr Gly Arg Glu Val Thr His Ile Gln Phe Thr Ser 
    690                 695                 700                 
Trp Pro Asp His Gly Val Pro Glu Asp Pro His Leu Leu Leu Lys Leu 
705                 710                 715                 720 
Arg Arg Arg Val Asn Ala Phe Ser Asn Phe Phe Ser Gly Pro Ile Val 
                725                 730                 735     
Val His Cys Ser Ala Gly Val Gly Arg Thr Gly Thr Tyr Ile Gly Ile 
            740                 745                 750         
Asp Ala Met Leu Glu Gly Leu Glu Ala Glu Asn Lys Val Asp Val Tyr 
        755                 760                 765             
Gly Tyr Val Val Lys Leu Arg Arg Gln Arg Cys Leu Met Val Gln Val 
    770                 775                 780                 
Glu Ala Gln Tyr Ile Leu Ile His Gln Ala Leu Val Glu Tyr Asn Gln 
785                 790                 795                 800 
Phe Gly Glu Thr Glu Val Asn Leu Ser Glu Leu His Pro Tyr Leu His 
                805                 810                 815     
Asn Met Lys Lys Arg Asp Pro Pro Ser Glu Pro Ser Pro Leu Glu Ala 
            820                 825                 830         
Glu Phe Gln Arg Leu Pro Ser Tyr Arg Ser Trp Arg Thr Gln His Ile 
        835                 840                 845             
Gly Asn Gln Glu Glu Asn Lys Ser Lys Asn Arg Asn Ser Asn Val Ile 
    850                 855                 860                 
Pro Tyr Asp Tyr Asn Arg Val Pro Leu Lys His Glu Leu Glu Met Ser 
865                 870                 875                 880 
Lys Glu Ser Glu His Asp Ser Asp Glu Ser Ser Asp Asp Asp Ser Asp 
                885                 890                 895     
Ser Glu Glu Pro Ser Lys Tyr Ile Asn Ala Ser Phe Ile Met Ser Tyr 
            900                 905                 910         
Trp Lys Pro Glu Val Met Ile Ala Ala Gln Gly Pro Leu Lys Glu Thr 
        915                 920                 925             
Ile Gly Asp Phe Trp Gln Met Ile Phe Gln Arg Lys Val Lys Val Ile 
    930                 935                 940                 
Val Met Leu Thr Glu Leu Lys His Gly Asp Gln Glu Ile Cys Ala Gln 
945                 950                 955                 960 
Tyr Trp Gly Glu Gly Lys Gln Thr Tyr Gly Asp Ile Glu Val Asp Leu 
                965                 970                 975     
Lys Asp Thr Asp Lys Ser Ser Thr Tyr Thr Leu Arg Val Phe Glu Leu 
            980                 985                 990         
Arg His Ser Lys Arg Lys Asp Ser Arg Thr Val Tyr Gln Tyr Gln Tyr 
        995                 1000                1005            
Thr Asn Trp Ser Val Glu Gln Leu Pro Ala Glu Pro Lys Glu Leu Ile 
    1010                1015                1020                
Ser Met Ile Gln Val Val Lys Gln Lys Leu Pro Gln Lys Asn Ser Ser 
1025                1030                1035                1040
Glu Gly Asn Lys His His Lys Ser Thr Pro Leu Leu Ile His Cys Arg 
                1045                1050                1055    
Asp Gly Ser Gln Gln Thr Gly Ile Phe Cys Ala Leu Leu Asn Leu Leu 
            1060                1065                1070        
Glu Ser Ala Glu Thr Glu Glu Val Val Asp Ile Phe Gln Val Val Lys 
        1075                1080                1085            
Ala Leu Arg Lys Ala Arg Pro Gly Met Val Ser Thr Phe Glu Gln Tyr 
    1090                1095                1100                
Gln Phe Leu Tyr Asp Val Ile Ala Ser Thr Tyr Pro Ala Gln Asn Gly 
1105                1110                1115                1120
Gln Val Lys Lys Asn Asn His Gln Glu Asp Lys Ile Glu Phe Asp Asn 
                1125                1130                1135    
Glu Val Asp Lys Val Lys Gln Asp Ala Asn Cys Val Asn Pro Leu Gly 
            1140                1145                1150        
Ala Pro Glu Lys Leu Pro Glu Ala Lys Glu Gln Ala Glu Gly Ser Glu 
        1155                1160                1165            
Pro Thr Ser Gly Thr Glu Gly Pro Glu His Ser Val Asn Gly Pro Ala 
    1170                1175                1180                
Ser Pro Ala Leu Asn Gln Gly Ser 
1185                1190        

<210> 109
<211> 1258
<212> PRT
<213> Homo sapiens


<220> 
<223> hCD45RAB

<300> 
<308> UniProt Accession P08575-5
<309> 2018 03 28

<400> 109
Met Thr Met Tyr Leu Trp Leu Lys Leu Leu Ala Phe Gly Phe Ala Phe 
1               5                   10                  15      
Leu Asp Thr Glu Val Phe Val Thr Gly Gln Ser Pro Thr Pro Ser Pro 
            20                  25                  30          
Thr Gly Leu Thr Thr Ala Lys Met Pro Ser Val Pro Leu Ser Ser Asp 
        35                  40                  45              
Pro Leu Pro Thr His Thr Thr Ala Phe Ser Pro Ala Ser Thr Phe Glu 
    50                  55                  60                  
Arg Glu Asn Asp Phe Ser Glu Thr Thr Thr Ser Leu Ser Pro Asp Asn 
65                  70                  75                  80  
Thr Ser Thr Gln Val Ser Pro Asp Ser Leu Asp Asn Ala Ser Ala Phe 
                85                  90                  95      
Asn Thr Thr Gly Val Ser Ser Val Gln Thr Pro His Leu Pro Thr His 
            100                 105                 110         
Ala Asp Ser Gln Thr Pro Ser Ala Gly Thr Asp Thr Gln Thr Phe Ser 
        115                 120                 125             
Gly Ser Ala Ala Asn Ala Lys Leu Asn Pro Thr Pro Gly Ser Asn Ala 
    130                 135                 140                 
Ile Ser Asp Ala Tyr Leu Asn Ala Ser Glu Thr Thr Thr Leu Ser Pro 
145                 150                 155                 160 
Ser Gly Ser Ala Val Ile Ser Thr Thr Thr Ile Ala Thr Thr Pro Ser 
                165                 170                 175     
Lys Pro Thr Cys Asp Glu Lys Tyr Ala Asn Ile Thr Val Asp Tyr Leu 
            180                 185                 190         
Tyr Asn Lys Glu Thr Lys Leu Phe Thr Ala Lys Leu Asn Val Asn Glu 
        195                 200                 205             
Asn Val Glu Cys Gly Asn Asn Thr Cys Thr Asn Asn Glu Val His Asn 
    210                 215                 220                 
Leu Thr Glu Cys Lys Asn Ala Ser Val Ser Ile Ser His Asn Ser Cys 
225                 230                 235                 240 
Thr Ala Pro Asp Lys Thr Leu Ile Leu Asp Val Pro Pro Gly Val Glu 
                245                 250                 255     
Lys Phe Gln Leu His Asp Cys Thr Gln Val Glu Lys Ala Asp Thr Thr 
            260                 265                 270         
Ile Cys Leu Lys Trp Lys Asn Ile Glu Thr Phe Thr Cys Asp Thr Gln 
        275                 280                 285             
Asn Ile Thr Tyr Arg Phe Gln Cys Gly Asn Met Ile Phe Asp Asn Lys 
    290                 295                 300                 
Glu Ile Lys Leu Glu Asn Leu Glu Pro Glu His Glu Tyr Lys Cys Asp 
305                 310                 315                 320 
Ser Glu Ile Leu Tyr Asn Asn His Lys Phe Thr Asn Ala Ser Lys Ile 
                325                 330                 335     
Ile Lys Thr Asp Phe Gly Ser Pro Gly Glu Pro Gln Ile Ile Phe Cys 
            340                 345                 350         
Arg Ser Glu Ala Ala His Gln Gly Val Ile Thr Trp Asn Pro Pro Gln 
        355                 360                 365             
Arg Ser Phe His Asn Phe Thr Leu Cys Tyr Ile Lys Glu Thr Glu Lys 
    370                 375                 380                 
Asp Cys Leu Asn Leu Asp Lys Asn Leu Ile Lys Tyr Asp Leu Gln Asn 
385                 390                 395                 400 
Leu Lys Pro Tyr Thr Lys Tyr Val Leu Ser Leu His Ala Tyr Ile Ile 
                405                 410                 415     
Ala Lys Val Gln Arg Asn Gly Ser Ala Ala Met Cys His Phe Thr Thr 
            420                 425                 430         
Lys Ser Ala Pro Pro Ser Gln Val Trp Asn Met Thr Val Ser Met Thr 
        435                 440                 445             
Ser Asp Asn Ser Met His Val Lys Cys Arg Pro Pro Arg Asp Arg Asn 
    450                 455                 460                 
Gly Pro His Glu Arg Tyr His Leu Glu Val Glu Ala Gly Asn Thr Leu 
465                 470                 475                 480 
Val Arg Asn Glu Ser His Lys Asn Cys Asp Phe Arg Val Lys Asp Leu 
                485                 490                 495     
Gln Tyr Ser Thr Asp Tyr Thr Phe Lys Ala Tyr Phe His Asn Gly Asp 
            500                 505                 510         
Tyr Pro Gly Glu Pro Phe Ile Leu His His Ser Thr Ser Tyr Asn Ser 
        515                 520                 525             
Lys Ala Leu Ile Ala Phe Leu Ala Phe Leu Ile Ile Val Thr Ser Ile 
    530                 535                 540                 
Ala Leu Leu Val Val Leu Tyr Lys Ile Tyr Asp Leu His Lys Lys Arg 
545                 550                 555                 560 
Ser Cys Asn Leu Asp Glu Gln Gln Glu Leu Val Glu Arg Asp Asp Glu 
                565                 570                 575     
Lys Gln Leu Met Asn Val Glu Pro Ile His Ala Asp Ile Leu Leu Glu 
            580                 585                 590         
Thr Tyr Lys Arg Lys Ile Ala Asp Glu Gly Arg Leu Phe Leu Ala Glu 
        595                 600                 605             
Phe Gln Ser Ile Pro Arg Val Phe Ser Lys Phe Pro Ile Lys Glu Ala 
    610                 615                 620                 
Arg Lys Pro Phe Asn Gln Asn Lys Asn Arg Tyr Val Asp Ile Leu Pro 
625                 630                 635                 640 
Tyr Asp Tyr Asn Arg Val Glu Leu Ser Glu Ile Asn Gly Asp Ala Gly 
                645                 650                 655     
Ser Asn Tyr Ile Asn Ala Ser Tyr Ile Asp Gly Phe Lys Glu Pro Arg 
            660                 665                 670         
Lys Tyr Ile Ala Ala Gln Gly Pro Arg Asp Glu Thr Val Asp Asp Phe 
        675                 680                 685             
Trp Arg Met Ile Trp Glu Gln Lys Ala Thr Val Ile Val Met Val Thr 
    690                 695                 700                 
Arg Cys Glu Glu Gly Asn Arg Asn Lys Cys Ala Glu Tyr Trp Pro Ser 
705                 710                 715                 720 
Met Glu Glu Gly Thr Arg Ala Phe Gly Asp Val Val Val Lys Ile Asn 
                725                 730                 735     
Gln His Lys Arg Cys Pro Asp Tyr Ile Ile Gln Lys Leu Asn Ile Val 
            740                 745                 750         
Asn Lys Lys Glu Lys Ala Thr Gly Arg Glu Val Thr His Ile Gln Phe 
        755                 760                 765             
Thr Ser Trp Pro Asp His Gly Val Pro Glu Asp Pro His Leu Leu Leu 
    770                 775                 780                 
Lys Leu Arg Arg Arg Val Asn Ala Phe Ser Asn Phe Phe Ser Gly Pro 
785                 790                 795                 800 
Ile Val Val His Cys Ser Ala Gly Val Gly Arg Thr Gly Thr Tyr Ile 
                805                 810                 815     
Gly Ile Asp Ala Met Leu Glu Gly Leu Glu Ala Glu Asn Lys Val Asp 
            820                 825                 830         
Val Tyr Gly Tyr Val Val Lys Leu Arg Arg Gln Arg Cys Leu Met Val 
        835                 840                 845             
Gln Val Glu Ala Gln Tyr Ile Leu Ile His Gln Ala Leu Val Glu Tyr 
    850                 855                 860                 
Asn Gln Phe Gly Glu Thr Glu Val Asn Leu Ser Glu Leu His Pro Tyr 
865                 870                 875                 880 
Leu His Asn Met Lys Lys Arg Asp Pro Pro Ser Glu Pro Ser Pro Leu 
                885                 890                 895     
Glu Ala Glu Phe Gln Arg Leu Pro Ser Tyr Arg Ser Trp Arg Thr Gln 
            900                 905                 910         
His Ile Gly Asn Gln Glu Glu Asn Lys Ser Lys Asn Arg Asn Ser Asn 
        915                 920                 925             
Val Ile Pro Tyr Asp Tyr Asn Arg Val Pro Leu Lys His Glu Leu Glu 
    930                 935                 940                 
Met Ser Lys Glu Ser Glu His Asp Ser Asp Glu Ser Ser Asp Asp Asp 
945                 950                 955                 960 
Ser Asp Ser Glu Glu Pro Ser Lys Tyr Ile Asn Ala Ser Phe Ile Met 
                965                 970                 975     
Ser Tyr Trp Lys Pro Glu Val Met Ile Ala Ala Gln Gly Pro Leu Lys 
            980                 985                 990         
Glu Thr Ile Gly Asp Phe Trp Gln Met Ile Phe Gln Arg Lys Val Lys 
        995                 1000                1005            
Val Ile Val Met Leu Thr Glu Leu Lys His Gly Asp Gln Glu Ile Cys 
    1010                1015                1020                
Ala Gln Tyr Trp Gly Glu Gly Lys Gln Thr Tyr Gly Asp Ile Glu Val 
1025                1030                1035                1040
Asp Leu Lys Asp Thr Asp Lys Ser Ser Thr Tyr Thr Leu Arg Val Phe 
                1045                1050                1055    
Glu Leu Arg His Ser Lys Arg Lys Asp Ser Arg Thr Val Tyr Gln Tyr 
            1060                1065                1070        
Gln Tyr Thr Asn Trp Ser Val Glu Gln Leu Pro Ala Glu Pro Lys Glu 
        1075                1080                1085            
Leu Ile Ser Met Ile Gln Val Val Lys Gln Lys Leu Pro Gln Lys Asn 
    1090                1095                1100                
Ser Ser Glu Gly Asn Lys His His Lys Ser Thr Pro Leu Leu Ile His 
1105                1110                1115                1120
Cys Arg Asp Gly Ser Gln Gln Thr Gly Ile Phe Cys Ala Leu Leu Asn 
                1125                1130                1135    
Leu Leu Glu Ser Ala Glu Thr Glu Glu Val Val Asp Ile Phe Gln Val 
            1140                1145                1150        
Val Lys Ala Leu Arg Lys Ala Arg Pro Gly Met Val Ser Thr Phe Glu 
        1155                1160                1165            
Gln Tyr Gln Phe Leu Tyr Asp Val Ile Ala Ser Thr Tyr Pro Ala Gln 
    1170                1175                1180                
Asn Gly Gln Val Lys Lys Asn Asn His Gln Glu Asp Lys Ile Glu Phe 
1185                1190                1195                1200
Asp Asn Glu Val Asp Lys Val Lys Gln Asp Ala Asn Cys Val Asn Pro 
                1205                1210                1215    
Leu Gly Ala Pro Glu Lys Leu Pro Glu Ala Lys Glu Gln Ala Glu Gly 
            1220                1225                1230        
Ser Glu Pro Thr Ser Gly Thr Glu Gly Pro Glu His Ser Val Asn Gly 
        1235                1240                1245            
Pro Ala Ser Pro Ala Leu Asn Gln Gly Ser 
    1250                1255            

<210> 110
<211> 1145
<212> PRT
<213> Homo sapiens


<220> 
<223> hCD45R0

<300> 
<308> UniProt Accession P08575-4
<309> 2018 03 28

<400> 110
Met Thr Met Tyr Leu Trp Leu Lys Leu Leu Ala Phe Gly Phe Ala Phe 
1               5                   10                  15      
Leu Asp Thr Glu Val Phe Val Thr Gly Gln Ser Pro Thr Pro Ser Pro 
            20                  25                  30          
Thr Asp Ala Tyr Leu Asn Ala Ser Glu Thr Thr Thr Leu Ser Pro Ser 
        35                  40                  45              
Gly Ser Ala Val Ile Ser Thr Thr Thr Ile Ala Thr Thr Pro Ser Lys 
    50                  55                  60                  
Pro Thr Cys Asp Glu Lys Tyr Ala Asn Ile Thr Val Asp Tyr Leu Tyr 
65                  70                  75                  80  
Asn Lys Glu Thr Lys Leu Phe Thr Ala Lys Leu Asn Val Asn Glu Asn 
                85                  90                  95      
Val Glu Cys Gly Asn Asn Thr Cys Thr Asn Asn Glu Val His Asn Leu 
            100                 105                 110         
Thr Glu Cys Lys Asn Ala Ser Val Ser Ile Ser His Asn Ser Cys Thr 
        115                 120                 125             
Ala Pro Asp Lys Thr Leu Ile Leu Asp Val Pro Pro Gly Val Glu Lys 
    130                 135                 140                 
Phe Gln Leu His Asp Cys Thr Gln Val Glu Lys Ala Asp Thr Thr Ile 
145                 150                 155                 160 
Cys Leu Lys Trp Lys Asn Ile Glu Thr Phe Thr Cys Asp Thr Gln Asn 
                165                 170                 175     
Ile Thr Tyr Arg Phe Gln Cys Gly Asn Met Ile Phe Asp Asn Lys Glu 
            180                 185                 190         
Ile Lys Leu Glu Asn Leu Glu Pro Glu His Glu Tyr Lys Cys Asp Ser 
        195                 200                 205             
Glu Ile Leu Tyr Asn Asn His Lys Phe Thr Asn Ala Ser Lys Ile Ile 
    210                 215                 220                 
Lys Thr Asp Phe Gly Ser Pro Gly Glu Pro Gln Ile Ile Phe Cys Arg 
225                 230                 235                 240 
Ser Glu Ala Ala His Gln Gly Val Ile Thr Trp Asn Pro Pro Gln Arg 
                245                 250                 255     
Ser Phe His Asn Phe Thr Leu Cys Tyr Ile Lys Glu Thr Glu Lys Asp 
            260                 265                 270         
Cys Leu Asn Leu Asp Lys Asn Leu Ile Lys Tyr Asp Leu Gln Asn Leu 
        275                 280                 285             
Lys Pro Tyr Thr Lys Tyr Val Leu Ser Leu His Ala Tyr Ile Ile Ala 
    290                 295                 300                 
Lys Val Gln Arg Asn Gly Ser Ala Ala Met Cys His Phe Thr Thr Lys 
305                 310                 315                 320 
Ser Ala Pro Pro Ser Gln Val Trp Asn Met Thr Val Ser Met Thr Ser 
                325                 330                 335     
Asp Asn Ser Met His Val Lys Cys Arg Pro Pro Arg Asp Arg Asn Gly 
            340                 345                 350         
Pro His Glu Arg Tyr His Leu Glu Val Glu Ala Gly Asn Thr Leu Val 
        355                 360                 365             
Arg Asn Glu Ser His Lys Asn Cys Asp Phe Arg Val Lys Asp Leu Gln 
    370                 375                 380                 
Tyr Ser Thr Asp Tyr Thr Phe Lys Ala Tyr Phe His Asn Gly Asp Tyr 
385                 390                 395                 400 
Pro Gly Glu Pro Phe Ile Leu His His Ser Thr Ser Tyr Asn Ser Lys 
                405                 410                 415     
Ala Leu Ile Ala Phe Leu Ala Phe Leu Ile Ile Val Thr Ser Ile Ala 
            420                 425                 430         
Leu Leu Val Val Leu Tyr Lys Ile Tyr Asp Leu His Lys Lys Arg Ser 
        435                 440                 445             
Cys Asn Leu Asp Glu Gln Gln Glu Leu Val Glu Arg Asp Asp Glu Lys 
    450                 455                 460                 
Gln Leu Met Asn Val Glu Pro Ile His Ala Asp Ile Leu Leu Glu Thr 
465                 470                 475                 480 
Tyr Lys Arg Lys Ile Ala Asp Glu Gly Arg Leu Phe Leu Ala Glu Phe 
                485                 490                 495     
Gln Ser Ile Pro Arg Val Phe Ser Lys Phe Pro Ile Lys Glu Ala Arg 
            500                 505                 510         
Lys Pro Phe Asn Gln Asn Lys Asn Arg Tyr Val Asp Ile Leu Pro Tyr 
        515                 520                 525             
Asp Tyr Asn Arg Val Glu Leu Ser Glu Ile Asn Gly Asp Ala Gly Ser 
    530                 535                 540                 
Asn Tyr Ile Asn Ala Ser Tyr Ile Asp Gly Phe Lys Glu Pro Arg Lys 
545                 550                 555                 560 
Tyr Ile Ala Ala Gln Gly Pro Arg Asp Glu Thr Val Asp Asp Phe Trp 
                565                 570                 575     
Arg Met Ile Trp Glu Gln Lys Ala Thr Val Ile Val Met Val Thr Arg 
            580                 585                 590         
Cys Glu Glu Gly Asn Arg Asn Lys Cys Ala Glu Tyr Trp Pro Ser Met 
        595                 600                 605             
Glu Glu Gly Thr Arg Ala Phe Gly Asp Val Val Val Lys Ile Asn Gln 
    610                 615                 620                 
His Lys Arg Cys Pro Asp Tyr Ile Ile Gln Lys Leu Asn Ile Val Asn 
625                 630                 635                 640 
Lys Lys Glu Lys Ala Thr Gly Arg Glu Val Thr His Ile Gln Phe Thr 
                645                 650                 655     
Ser Trp Pro Asp His Gly Val Pro Glu Asp Pro His Leu Leu Leu Lys 
            660                 665                 670         
Leu Arg Arg Arg Val Asn Ala Phe Ser Asn Phe Phe Ser Gly Pro Ile 
        675                 680                 685             
Val Val His Cys Ser Ala Gly Val Gly Arg Thr Gly Thr Tyr Ile Gly 
    690                 695                 700                 
Ile Asp Ala Met Leu Glu Gly Leu Glu Ala Glu Asn Lys Val Asp Val 
705                 710                 715                 720 
Tyr Gly Tyr Val Val Lys Leu Arg Arg Gln Arg Cys Leu Met Val Gln 
                725                 730                 735     
Val Glu Ala Gln Tyr Ile Leu Ile His Gln Ala Leu Val Glu Tyr Asn 
            740                 745                 750         
Gln Phe Gly Glu Thr Glu Val Asn Leu Ser Glu Leu His Pro Tyr Leu 
        755                 760                 765             
His Asn Met Lys Lys Arg Asp Pro Pro Ser Glu Pro Ser Pro Leu Glu 
    770                 775                 780                 
Ala Glu Phe Gln Arg Leu Pro Ser Tyr Arg Ser Trp Arg Thr Gln His 
785                 790                 795                 800 
Ile Gly Asn Gln Glu Glu Asn Lys Ser Lys Asn Arg Asn Ser Asn Val 
                805                 810                 815     
Ile Pro Tyr Asp Tyr Asn Arg Val Pro Leu Lys His Glu Leu Glu Met 
            820                 825                 830         
Ser Lys Glu Ser Glu His Asp Ser Asp Glu Ser Ser Asp Asp Asp Ser 
        835                 840                 845             
Asp Ser Glu Glu Pro Ser Lys Tyr Ile Asn Ala Ser Phe Ile Met Ser 
    850                 855                 860                 
Tyr Trp Lys Pro Glu Val Met Ile Ala Ala Gln Gly Pro Leu Lys Glu 
865                 870                 875                 880 
Thr Ile Gly Asp Phe Trp Gln Met Ile Phe Gln Arg Lys Val Lys Val 
                885                 890                 895     
Ile Val Met Leu Thr Glu Leu Lys His Gly Asp Gln Glu Ile Cys Ala 
            900                 905                 910         
Gln Tyr Trp Gly Glu Gly Lys Gln Thr Tyr Gly Asp Ile Glu Val Asp 
        915                 920                 925             
Leu Lys Asp Thr Asp Lys Ser Ser Thr Tyr Thr Leu Arg Val Phe Glu 
    930                 935                 940                 
Leu Arg His Ser Lys Arg Lys Asp Ser Arg Thr Val Tyr Gln Tyr Gln 
945                 950                 955                 960 
Tyr Thr Asn Trp Ser Val Glu Gln Leu Pro Ala Glu Pro Lys Glu Leu 
                965                 970                 975     
Ile Ser Met Ile Gln Val Val Lys Gln Lys Leu Pro Gln Lys Asn Ser 
            980                 985                 990         
Ser Glu Gly Asn Lys His His Lys Ser Thr Pro Leu Leu Ile His Cys 
        995                 1000                1005            
Arg Asp Gly Ser Gln Gln Thr Gly Ile Phe Cys Ala Leu Leu Asn Leu 
    1010                1015                1020                
Leu Glu Ser Ala Glu Thr Glu Glu Val Val Asp Ile Phe Gln Val Val 
1025                1030                1035                1040
Lys Ala Leu Arg Lys Ala Arg Pro Gly Met Val Ser Thr Phe Glu Gln 
                1045                1050                1055    
Tyr Gln Phe Leu Tyr Asp Val Ile Ala Ser Thr Tyr Pro Ala Gln Asn 
            1060                1065                1070        
Gly Gln Val Lys Lys Asn Asn His Gln Glu Asp Lys Ile Glu Phe Asp 
        1075                1080                1085            
Asn Glu Val Asp Lys Val Lys Gln Asp Ala Asn Cys Val Asn Pro Leu 
    1090                1095                1100                
Gly Ala Pro Glu Lys Leu Pro Glu Ala Lys Glu Gln Ala Glu Gly Ser 
1105                1110                1115                1120
Glu Pro Thr Ser Gly Thr Glu Gly Pro Glu His Ser Val Asn Gly Pro 
                1125                1130                1135    
Ala Ser Pro Ala Leu Asn Gln Gly Ser 
            1140                1145

<210> 111
<211> 7
<212> PRT
<213> Artificial Sequence


<220> 
<223> VL-CDR2

<400> 111
Ala Thr Ser Asn Leu Pro Ser 
1               5           

<210> 112
<211> 107
<212> PRT
<213> Artificial Sequence


<220> 
<223> Humanized LCVR

<220> 
<221> SITE
<222> 31
<223> Xaa is selected from Asn (N), Ser (S) and Gly (G)

<400> 112
Asp Ile Gln Leu Thr Gln Ser Pro Ser Phe Leu Ser Ala Ser Val Gly 
1               5                   10                  15      
Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Ser Ser Val Ser Xaa Tyr 
            20                  25                  30          
Met His Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Trp Ile 
        35                  40                  45              
Tyr Ala Thr Ser Asn Leu Pro Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  
Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  
Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Arg Ser Ser Tyr Pro Leu 
                85                  90                  95      
Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105         

<210> 113
<211> 106
<212> PRT
<213> Artificial Sequence


<220> 
<223> Humanized LCVR

<400> 113
Asp Ile Gln Leu Thr Gln Ser Pro Ser Phe Leu Ser Ala Ser Val Gly 
1               5                   10                  15      
Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Ser Ser Val Ser Tyr Met 
            20                  25                  30          
His Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Trp Ile Tyr 
        35                  40                  45              
Ala Thr Ser Asn Leu Pro Ser Gly Val Pro Ser Arg Phe Ser Gly Ser 
    50                  55                  60                  
Gly Ser Gly Thr Glu Tyr Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu 
65                  70                  75                  80  
Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Arg Ser Ser Tyr Pro Leu Thr 
                85                  90                  95      
Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105     

<210> 114
<211> 330
<212> PRT
<213> Artificial Sequence


<220> 
<223> Human HCCR

<400> 114
Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys 
1               5                   10                  15      
Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
            20                  25                  30          
Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        35                  40                  45              
Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  
Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr 
65                  70                  75                  80  
Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys 
                85                  90                  95      
Arg Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys 
            100                 105                 110         
Pro Ala Pro Glu Ala Ala Gly Gly Pro Ser Val Phe Leu Phe Pro Pro 
        115                 120                 125             
Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys 
    130                 135                 140                 
Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp 
145                 150                 155                 160 
Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu 
                165                 170                 175     
Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu 
            180                 185                 190         
His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn 
        195                 200                 205             
Lys Ala Leu Pro Ser Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly 
    210                 215                 220                 
Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu 
225                 230                 235                 240 
Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr 
                245                 250                 255     
Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn 
            260                 265                 270         
Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe 
        275                 280                 285             
Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn 
    290                 295                 300                 
Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr 
305                 310                 315                 320 
Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
                325                 330 

<210> 115
<211> 113
<212> PRT
<213> Artificial Sequence


<220> 
<223> Human HCCR

<400> 115
Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys 
1               5                   10                  15      
Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
            20                  25                  30          
Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        35                  40                  45              
Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  
Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr 
65                  70                  75                  80  
Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys 
                85                  90                  95      
Arg Val Glu Pro Lys Ser Cys Val Ala Ala Ala His His His His His 
            100                 105                 110         
His 
    

<210> 116
<211> 17
<212> PRT
<213> Artificial Sequence


<220> 
<223> VH-CDR2

<400> 116
Asp Ile Phe Pro Gly Gly Gly Tyr Ala Asn Tyr Ala Glu Lys Phe Gln 
1               5                   10                  15      
Gly 
    

<210> 117
<211> 17
<212> PRT
<213> Artificial Sequence


<220> 
<223> VH-CDR2

<400> 117
Asp Ile Phe Pro Gly Gly Gly Tyr Thr Asn Tyr Ala Glu Lys Phe Lys 
1               5                   10                  15      
Gly 
    

<210> 118
<211> 17
<212> PRT
<213> Artificial Sequence


<220> 
<223> VH-CDR2

<400> 118
Asp Ile Phe Pro Gly Gly Gly Tyr Thr Asn Tyr Asn Glu Lys Phe Gln 
1               5                   10                  15      
Gly 
    

<210> 119
<211> 17
<212> PRT
<213> Artificial Sequence


<220> 
<223> VH-CDR2

<400> 119
Asp Ile Phe Pro Gly Gly Gly Tyr Thr Asn Ser Ala Glu Lys Phe Gln 
1               5                   10                  15      
Gly 
    

<210> 120
<211> 7
<212> PRT
<213> Artificial Sequence


<220> 
<223> VL-CDR2

<400> 120
Asn Thr Ala Asn Leu Pro Ser 
1               5           

<210> 121
<211> 114
<212> PRT
<213> Artificial Sequence


<220> 
<223> Humanized HCVR

<400> 121
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      
Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asn Tyr 
            20                  25                  30          
Tyr Ile Gly Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              
Gly Asp Ile Phe Pro Gly Gly Gly Tyr Ala Asn Tyr Ala Glu Lys Phe 
    50                  55                  60                  
Gln Gly Arg Val Thr Leu Thr Ala Asp Thr Ser Ile Ser Thr Ala Tyr 
65                  70                  75                  80  
Met Glu Leu Ser Arg Leu Arg Ser Asp Asp Thr Val Val Tyr Tyr Cys 
                85                  90                  95      
Val Arg Arg Asn Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val 
            100                 105                 110         
Ser Ser 
        

<210> 122
<211> 114
<212> PRT
<213> Artificial Sequence


<220> 
<223> Humanized HCVR

<400> 122
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      
Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asn Tyr 
            20                  25                  30          
Tyr Ile Gly Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              
Gly Asp Ile Phe Pro Gly Gly Gly Tyr Thr Asn Tyr Ala Glu Lys Phe 
    50                  55                  60                  
Lys Gly Arg Val Thr Leu Thr Ala Asp Thr Ser Ile Ser Thr Ala Tyr 
65                  70                  75                  80  
Met Glu Leu Ser Arg Leu Arg Ser Asp Asp Thr Val Val Tyr Tyr Cys 
                85                  90                  95      
Val Arg Arg Asn Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val 
            100                 105                 110         
Ser Ser 
        

<210> 123
<211> 114
<212> PRT
<213> Artificial Sequence


<220> 
<223> Humanized HCVR

<400> 123
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      
Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asn Tyr 
            20                  25                  30          
Tyr Ile Gly Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              
Gly Asp Ile Phe Pro Gly Gly Gly Tyr Thr Asn Tyr Asn Glu Lys Phe 
    50                  55                  60                  
Gln Gly Arg Val Thr Leu Thr Ala Asp Thr Ser Ile Ser Thr Ala Tyr 
65                  70                  75                  80  
Met Glu Leu Ser Arg Leu Arg Ser Asp Asp Thr Val Val Tyr Tyr Cys 
                85                  90                  95      
Val Arg Arg Asn Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val 
            100                 105                 110         
Ser Ser 
        

<210> 124
<211> 114
<212> PRT
<213> Artificial Sequence


<220> 
<223> Humanized HCVR

<400> 124
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      
Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asn Tyr 
            20                  25                  30          
Tyr Ile Gly Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              
Gly Asp Ile Phe Pro Gly Gly Gly Tyr Thr Asn Ser Ala Glu Lys Phe 
    50                  55                  60                  
Gln Gly Arg Val Thr Leu Thr Ala Asp Thr Ser Ile Ser Thr Ala Tyr 
65                  70                  75                  80  
Met Glu Leu Ser Arg Leu Arg Ser Asp Asp Thr Val Val Tyr Tyr Cys 
                85                  90                  95      
Val Arg Arg Asn Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val 
            100                 105                 110         
Ser Ser 
        

<210> 125
<211> 107
<212> PRT
<213> Artificial Sequence


<220> 
<223> Humanized LCVR

<220> 
<221> SITE
<222> 31
<223> Xaa is selected from Asn (N), Ser (S) and Gly (G)

<400> 125
Gln Ile Val Leu Thr Gln Ser Pro Thr Ile Met Ser Ala Ser Pro Gly 
1               5                   10                  15      
Glu Lys Val Thr Ile Thr Cys Ser Ala Ser Ser Ser Val Ser Xaa Tyr 
            20                  25                  30          
Met His Trp Phe Gln Gln Lys Thr Gly Thr Ser Pro Arg Leu Trp Ile 
        35                  40                  45              
Tyr Asn Thr Ala Asn Leu Pro Ser Gly Val Pro Ala Arg Phe Ser Gly 
    50                  55                  60                  
Ser Gly Ser Gly Thr Ser Phe Ser Leu Thr Ile Ser Arg Met Glu Ala 
65                  70                  75                  80  
Glu Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Arg Ser Ser Tyr Pro Leu 
                85                  90                  95      
Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys 
            100                 105         

<210> 126
<211> 106
<212> PRT
<213> Artificial Sequence


<220> 
<223> Humanized LCVR

<400> 126
Gln Ile Val Leu Thr Gln Ser Pro Thr Ile Met Ser Ala Ser Pro Gly 
1               5                   10                  15      
Glu Lys Val Thr Ile Thr Cys Ser Ala Ser Ser Ser Val Ser Tyr Met 
            20                  25                  30          
His Trp Phe Gln Gln Lys Thr Gly Thr Ser Pro Arg Leu Trp Ile Tyr 
        35                  40                  45              
Asn Thr Ala Asn Leu Pro Ser Gly Val Pro Ala Arg Phe Ser Gly Ser 
    50                  55                  60                  
Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile Ser Arg Met Glu Ala Glu 
65                  70                  75                  80  
Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Arg Ser Ser Tyr Pro Leu Thr 
                85                  90                  95      
Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys 
            100                 105     

<210> 127
<211> 7
<212> PRT
<213> Artificial Sequence


<220> 
<221> SITE
<222> 1
<223> Xaa is any amino acid but Ala (A) or Asn (N)

<220> 
<223> VL-CDR2

<400> 127
Xaa Thr Ser Asn Leu Pro Ser 
1               5           

<210> 128
<211> 107
<212> PRT
<213> Artificial Sequence


<220> 
<223> Humanized LCVR

<220> 
<221> SITE
<222> 31
<223> Xaa is selected from Asn (N), Ser (S) and Gly (G)

<220> 
<221> SITE
<222> 50
<223> Xaa is any amino acid but Ala (A) or Asn (N)

<400> 128
Asp Ile Gln Leu Thr Gln Ser Pro Ser Phe Leu Ser Ala Ser Val Gly 
1               5                   10                  15      
Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Ser Ser Val Ser Xaa Tyr 
            20                  25                  30          
Met His Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Trp Ile 
        35                  40                  45              
Tyr Xaa Thr Ser Asn Leu Pro Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  
Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  
Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Arg Ser Ser Tyr Pro Leu 
                85                  90                  95      
Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105         

<210> 129
<211> 106
<212> PRT
<213> Artificial Sequence


<220> 
<223> Humanized LCVR

<220> 
<221> SITE
<222> 49
<223> Xaa is any amino acid but Ala (A) or Asn (N)

<400> 129
Asp Ile Gln Leu Thr Gln Ser Pro Ser Phe Leu Ser Ala Ser Val Gly 
1               5                   10                  15      
Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Ser Ser Val Ser Tyr Met 
            20                  25                  30          
His Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Trp Ile Tyr 
        35                  40                  45              
Xaa Thr Ser Asn Leu Pro Ser Gly Val Pro Ser Arg Phe Ser Gly Ser 
    50                  55                  60                  
Gly Ser Gly Thr Glu Tyr Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu 
65                  70                  75                  80  
Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Arg Ser Ser Tyr Pro Leu Thr 
                85                  90                  95      
Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105     

