                         SEQUENCE LISTING

<110>  Lallemand USA
 
<120>  OPTIMIZATION OF YEAST HOST CELLS FOR THE PRODUCTION OF 
       HETEROLOGOUS PROTEINS

<130>  55729550-31PCT

<150>  62/733,471	
<151>  2018-09-19 

<160>  8     

<170>  PatentIn version 3.5

<210>  1
<211>  6081
<212>  DNA
<213>  Saccharomyces cerevisiae

<400>  1
atgtcatcaa aacctgatac tggttcggaa atttctggcc ctcagcgaca ggaagaacaa       60

gaacaacaga tagagcagag ctcacctacg gaagcaaacg atagaagcat tcatgatgag      120

gtaccaaaag tcaagaagcg tcacgaacaa aatagtggtc acaaatcaag aaggaatagc      180

gcatatagtt attacagccc acggtcgctt tctatgacca aaagcaggga gagtatcact      240

ccaaatggta tggatgatgt aagtatttcg aacgtggaac atccaaggcc gacagaaccg      300

aaaatcaaaa ggggtccata tttactgaag aaaacattga gcagtctttc aatgacgagc      360

gcgaatagta ctcatgatga taataaagac cacggttacg ctttgaattc atccaagacg      420

cacaactaca catctactca taaccatcat gacggtcatc atgatcatca tcatgttcag      480

ttttttccca ataggaagcc atcattagcg gaaaccctat tcaaaaggtt ttcagggtca      540

aacagtcacg atggcaataa gtcaggaaag gaaagtaaag ttgctaacct ttccctttca      600

acggtaaatc ctgcacctgc taataggaaa ccttctaaag actccacttt atctaatcac      660

ttggctgata acgtgccaag cactttacga aggaaagtgt cctcattggt acgtggttct      720

tccgtccatg atataaataa tggtattgca gataaacaga ttagaccaaa ggctgttgcg      780

caatcagaaa atacattaca ttcatccgat gttcccaata gcaaacgctc gcacagaaaa      840

agctttctgc taggctccac atcttcttca agcagtagaa gaggttcaaa tgtcagttca      900

atgactaaca gtgacagtgc aagtatggcg acgtcgggta gtcatgttct ccaacataac      960

gtatctaatg tttctccaac tactaaaagt aaggacagcg ttaacagcga atccgccgat     1020

cacactaata ataaatccga gaaagtgact ccagaatata atgagaacat tccggaaaat     1080

tctaactctg acaacaaacg cgaagccaca acgcctacta tagaaacacc catttcatgt     1140

aaaccatccc ttttcaggct agatacaaac cttgaggatg ttactgatat tacaaagacg     1200

gtgccaccca ccgctgtcaa ttctacacta aattctacac acgggactga gactgcctca     1260

cccaaaacgg tgatcatgcc tgaaggtcct aggaagtcgg tgtcaatggc tgatctctcc     1320

gtcgctgccg cagcacctaa tggtgaattc acatcaactt ccaatgatag atcacaatgg     1380

gtagcacctc aaagctggga tgtggaaacc aaaaggaaaa aaacaaaacc taaagggaga     1440

tcgaaatcaa gaaggtcaag tatagatgct gatgaacttg atcccatgtc accggggcca     1500

ccttcaaaaa aagactctcg tcatcatcac gatcgaaagg ataacgaatc aatggtcact     1560

gcgggtgaca gtaactcaag ttttgttgat atatgtaaag aaaacgttcc gaatgatagc     1620

aagaccgcac tcgatactaa atctgtgaac cgcttaaaaa gtaatttggc tatgagtccc     1680

ccaagtatac gatatgctcc atcaaattta gatggggact acgacacgtc ttccacttcc     1740

tcatctttac cgtcctcatc tattagttca gaagatacat cttcctgcag cgattcctct     1800

tcgtacacta acgcgtatat ggaggccaac cgagagcagg ataataaaac accgatcctg     1860

aataaaacga aatcgtatac caagaaattt acatcctctt cggtaaatat gaattcacca     1920

gatggtgccc agagttctgg attattacta caagatgaga aggacgatga ggtcgagtgc     1980

caactggaac attactataa agatttcagt gatttagatc caaagaggca ctatgctatt     2040

cgtatattca atactgatga cacttttacg actctctcat gtactccagc gactaccgtc     2100

gaagagataa tacctgcact taaaagaaaa tttaacatta cagcgcaagg gaattttcaa     2160

atttccctga aggtgggaaa gttgtcaaaa attttgagac caacttcgaa acctatttta     2220

attgaaagaa aacttttact tttgaatggt tatcgaaagt cagacccact tcatattatg     2280

ggtatagagg atttaagttt tgtttttaag tttcttttcc atcctgtcac accttctcac     2340

tttactcctg aacaagaaca aagaataatg agaagcgaat ttgttcacgt agatttaagg     2400

aatatggatc tgactacacc tcccatcatt ttttaccagc atacgtcaga aatagaaagt     2460

ttagacgttt ctaataacgc aaatatattc ctacctctgg agttcattga aagctcgatt     2520

aaattattaa gtttgagaat ggttaatatt agagcatcta aatttccttc caatatcact     2580

aaggcgtata aactagtatc tttggaatta cagagaaact tcataagaaa agtaccgaac     2640

tcaatcatga aactgagtaa tttaacgata ttaaaccttc aatgtaatga gcttgaaagc     2700

ctaccggctg gatttgttga actgaaaaat ctgcaattgc tagacttgtc ttcaaacaag     2760

ttcatgcact acccagaagt tattaactac tgcaccaatc ttttacaaat agacctatca     2820

tataataaaa tccaaagctt accacagtcc actaagtacc tagtaaagct tgcgaagatg     2880

aacctttctc ataacaaact aaattttata ggcgacttat cggaaatgac agatttgagg     2940

acgctgaacc taagatataa cagaatatca tcaattaaga caaatgcgtc taacttgcag     3000

aacctttttt taacagataa tagaatttcg aactttgaag acactttgcc gaaactaaga     3060

gcccttgaaa ttcaagagaa tccaatcact tctatatcct tcaaagattt ttatccaaaa     3120

aacatgacaa gtttgacgtt gaacaaggca cagttatcga gtattcctgg agaattactc     3180

accaaactat ctttcctcga gaaacttgaa cttaatcaga ataatttgac tagactgcca     3240

caggagatat ccaagttgac taaattagtt ttcctttcag tggcgagaaa caaactagag     3300

tatattccac ccgagctatc tcaactgaaa agtttgagga cattagatct acattctaac     3360

aacataaggg actttgttga cggtatggaa aaccttgaac taacatcgct aaatatttca     3420

tcgaatgcat tcggtaactc tagcttagaa aattcttttt accataacat gtcatatggg     3480

tcaaagttat ctaaaagcct gatgtttttt attgctgcag acaatcaatt tgatgatgct     3540

atgtggcctc ttttcaattg ctttgtcaat ctgaaagtgc taaatctttc ttacaacaat     3600

ttttcagatg tatcgcacat gaaacttgag agcattaccg aattgtacct ctccggtaat     3660

aagctcacga cattgtcggg tgatacagtt ttgaaatgga gctctttaaa gactttaatg     3720

ttgaatagta accaaatgtt atctctgcct gcagaattat caaatctctc acagctaagt     3780

gtatttgatg ttggagcaaa tcaattaaag tataatatat caaactatca ttacgattgg     3840

aactggagga ataataaaga actaaaatat ttgaattttt caggaaatcg aaggtttgaa     3900

ataaagtcat ttataagtca cgatattgat gctgatttgt cagatctgac agtattacct     3960

cagttaaagg tactaggttt aatggacgta actttaaata ctaccaaagt accggatgaa     4020

aatgtcaatt tccgtttaag gacaactgca tcaataataa atgggatgcg ctacggtgtt     4080

gctgatacat taggtcaaag agactatgtg tcatctcgtg atgttacctt tgaaagattc     4140

cgcggaaatg acgacgaatg cttactatgt cttcatgata gtaaaaacca aaatgcagat     4200

tatggccaca atatatcaag aattgttaga gatatttacg ataaaatact gatcagacaa     4260

ctggaaaggt atggagacga aacagatgat aatataaaaa ctgcacttcg tttcagtttt     4320

ttgcaactga ataaggagat taacggaatg ctaaattctg ttgataatgg tgccgatgtt     4380

gccaatcttt catatgcaga cttgctaagt ggcgcttgct ctactgtgat atatatcaga     4440

gggaagaaac tcttcgctgc aaatttaggt gactgtatgg ctattttatc caaaaacaat     4500

ggtgactacc aaacgctaac caaacaacat ctcccaacaa agcgggaaga atacgagagg     4560

atcagaatat ctggcgggta tgtcaacaat ggaaaattag atggtgttgt agatgtgtct     4620

agagcagtgg gtttttttga tttgcttccc cacattcatg cttctcccga catatctgtc     4680

gtgacattaa caaaagcaga cgagatgctt attgtagcaa cgcataagtt atgggaatac     4740

atggacgtgg atacagtttg tgatatcgcg cgtgagaata gtactgatcc actccgtgcc     4800

gcagctgagt tgaaggatca tgccatggct tacggctgta cagagaatat tacaattttg     4860

tgccttgctc tttacgagaa cattcagcaa caaaatcggt tcactttaaa taaaaactct     4920

ttaatgacta gaagaagtac tttcgaggat actacattaa gaagacttca acctgagatt     4980

tctccgccaa caggtaacct agcaatggtc ttcactgata tcaaaagctc aaccttctta     5040

tgggagctat tccctaacgc aatgaggacc gcaataaaaa ctcacaatga cattatgcgt     5100

cgtcaactac gaatttacgg tggttacgaa gtaaagacag aaggagacgc ctttatggtg     5160

gcatttccta cgccaactag tggtctgaca tggtgcttaa gtgttcaatt aaaactcttg     5220

gatgcacaat ggccggagga aattacctca gttcaagacg gctgccaagt tacggataga     5280

aatggtaaca ttatctatca aggcctatca gttagaatgg gtattcattg gggctgccca     5340

gttccagagc ttgatttagt gactcaaaga atggactatt tggggccgat ggtcaataag     5400

gcagcaaggg tccagggcgt cgctgacggt ggtcagattg caatgagtag tgatttttac     5460

tctgaattca acaagataat gaagtatcat gagcgagtag tgaagggcaa ggaatctctc     5520

aaggaagttt atggtgaaga aattatcgga gaggttcttg aaagagaaat tgccatgctg     5580

gaaagtattg gttgggcatt ttttgacttt ggcgagcata agctaaaggg actcgaaacc     5640

aaagaactcg ttactattgc gtatcctaag attcttgctt ccagacacga atttgcatct     5700

gaagatgagc agtcaaaatt aatcaatgaa acgatgttgt ttcgtttaag agtcatttca     5760

aacagactgg aatctataat gtcagcttta agcggcggat ttattgaact agactctcgg     5820

acggagggaa gttatattaa atttaaccct aaagttgaaa atggtattat gcaatcgatt     5880

tctgagaagg atgcgttgtt attttttgat catgtaatta ctagaatcga atccagtgtg     5940

gcattattac atttacgaca acagaggtgt tcaggactgg aaatttgcag aaacgataaa     6000

acatctgctc gaagcaatat tttcaatgtt gttgacgaac ttttacaaat ggttaagaac     6060

gcaaaggatt tatcaacttg a                                               6081


<210>  2
<211>  2026
<212>  PRT
<213>  Saccharomyces cerevisiae

<400>  2

Met Ser Ser Lys Pro Asp Thr Gly Ser Glu Ile Ser Gly Pro Gln Arg 
1               5                   10                  15      


Gln Glu Glu Gln Glu Gln Gln Ile Glu Gln Ser Ser Pro Thr Glu Ala 
            20                  25                  30          


Asn Asp Arg Ser Ile His Asp Glu Val Pro Lys Val Lys Lys Arg His 
        35                  40                  45              


Glu Gln Asn Ser Gly His Lys Ser Arg Arg Asn Ser Ala Tyr Ser Tyr 
    50                  55                  60                  


Tyr Ser Pro Arg Ser Leu Ser Met Thr Lys Ser Arg Glu Ser Ile Thr 
65                  70                  75                  80  


Pro Asn Gly Met Asp Asp Val Ser Ile Ser Asn Val Glu His Pro Arg 
                85                  90                  95      


Pro Thr Glu Pro Lys Ile Lys Arg Gly Pro Tyr Leu Leu Lys Lys Thr 
            100                 105                 110         


Leu Ser Ser Leu Ser Met Thr Ser Ala Asn Ser Thr His Asp Asp Asn 
        115                 120                 125             


Lys Asp His Gly Tyr Ala Leu Asn Ser Ser Lys Thr His Asn Tyr Thr 
    130                 135                 140                 


Ser Thr His Asn His His Asp Gly His His Asp His His His Val Gln 
145                 150                 155                 160 


Phe Phe Pro Asn Arg Lys Pro Ser Leu Ala Glu Thr Leu Phe Lys Arg 
                165                 170                 175     


Phe Ser Gly Ser Asn Ser His Asp Gly Asn Lys Ser Gly Lys Glu Ser 
            180                 185                 190         


Lys Val Ala Asn Leu Ser Leu Ser Thr Val Asn Pro Ala Pro Ala Asn 
        195                 200                 205             


Arg Lys Pro Ser Lys Asp Ser Thr Leu Ser Asn His Leu Ala Asp Asn 
    210                 215                 220                 


Val Pro Ser Thr Leu Arg Arg Lys Val Ser Ser Leu Val Arg Gly Ser 
225                 230                 235                 240 


Ser Val His Asp Ile Asn Asn Gly Ile Ala Asp Lys Gln Ile Arg Pro 
                245                 250                 255     


Lys Ala Val Ala Gln Ser Glu Asn Thr Leu His Ser Ser Asp Val Pro 
            260                 265                 270         


Asn Ser Lys Arg Ser His Arg Lys Ser Phe Leu Leu Gly Ser Thr Ser 
        275                 280                 285             


Ser Ser Ser Ser Arg Arg Gly Ser Asn Val Ser Ser Met Thr Asn Ser 
    290                 295                 300                 


Asp Ser Ala Ser Met Ala Thr Ser Gly Ser His Val Leu Gln His Asn 
305                 310                 315                 320 


Val Ser Asn Val Ser Pro Thr Thr Lys Ser Lys Asp Ser Val Asn Ser 
                325                 330                 335     


Glu Ser Ala Asp His Thr Asn Asn Lys Ser Glu Lys Val Thr Pro Glu 
            340                 345                 350         


Tyr Asn Glu Asn Ile Pro Glu Asn Ser Asn Ser Asp Asn Lys Arg Glu 
        355                 360                 365             


Ala Thr Thr Pro Thr Ile Glu Thr Pro Ile Ser Cys Lys Pro Ser Leu 
    370                 375                 380                 


Phe Arg Leu Asp Thr Asn Leu Glu Asp Val Thr Asp Ile Thr Lys Thr 
385                 390                 395                 400 


Val Pro Pro Thr Ala Val Asn Ser Thr Leu Asn Ser Thr His Gly Thr 
                405                 410                 415     


Glu Thr Ala Ser Pro Lys Thr Val Ile Met Pro Glu Gly Pro Arg Lys 
            420                 425                 430         


Ser Val Ser Met Ala Asp Leu Ser Val Ala Ala Ala Ala Pro Asn Gly 
        435                 440                 445             


Glu Phe Thr Ser Thr Ser Asn Asp Arg Ser Gln Trp Val Ala Pro Gln 
    450                 455                 460                 


Ser Trp Asp Val Glu Thr Lys Arg Lys Lys Thr Lys Pro Lys Gly Arg 
465                 470                 475                 480 


Ser Lys Ser Arg Arg Ser Ser Ile Asp Ala Asp Glu Leu Asp Pro Met 
                485                 490                 495     


Ser Pro Gly Pro Pro Ser Lys Lys Asp Ser Arg His His His Asp Arg 
            500                 505                 510         


Lys Asp Asn Glu Ser Met Val Thr Ala Gly Asp Ser Asn Ser Ser Phe 
        515                 520                 525             


Val Asp Ile Cys Lys Glu Asn Val Pro Asn Asp Ser Lys Thr Ala Leu 
    530                 535                 540                 


Asp Thr Lys Ser Val Asn Arg Leu Lys Ser Asn Leu Ala Met Ser Pro 
545                 550                 555                 560 


Pro Ser Ile Arg Tyr Ala Pro Ser Asn Leu Asp Gly Asp Tyr Asp Thr 
                565                 570                 575     


Ser Ser Thr Ser Ser Ser Leu Pro Ser Ser Ser Ile Ser Ser Glu Asp 
            580                 585                 590         


Thr Ser Ser Cys Ser Asp Ser Ser Ser Tyr Thr Asn Ala Tyr Met Glu 
        595                 600                 605             


Ala Asn Arg Glu Gln Asp Asn Lys Thr Pro Ile Leu Asn Lys Thr Lys 
    610                 615                 620                 


Ser Tyr Thr Lys Lys Phe Thr Ser Ser Ser Val Asn Met Asn Ser Pro 
625                 630                 635                 640 


Asp Gly Ala Gln Ser Ser Gly Leu Leu Leu Gln Asp Glu Lys Asp Asp 
                645                 650                 655     


Glu Val Glu Cys Gln Leu Glu His Tyr Tyr Lys Asp Phe Ser Asp Leu 
            660                 665                 670         


Asp Pro Lys Arg His Tyr Ala Ile Arg Ile Phe Asn Thr Asp Asp Thr 
        675                 680                 685             


Phe Thr Thr Leu Ser Cys Thr Pro Ala Thr Thr Val Glu Glu Ile Ile 
    690                 695                 700                 


Pro Ala Leu Lys Arg Lys Phe Asn Ile Thr Ala Gln Gly Asn Phe Gln 
705                 710                 715                 720 


Ile Ser Leu Lys Val Gly Lys Leu Ser Lys Ile Leu Arg Pro Thr Ser 
                725                 730                 735     


Lys Pro Ile Leu Ile Glu Arg Lys Leu Leu Leu Leu Asn Gly Tyr Arg 
            740                 745                 750         


Lys Ser Asp Pro Leu His Ile Met Gly Ile Glu Asp Leu Ser Phe Val 
        755                 760                 765             


Phe Lys Phe Leu Phe His Pro Val Thr Pro Ser His Phe Thr Pro Glu 
    770                 775                 780                 


Gln Glu Gln Arg Ile Met Arg Ser Glu Phe Val His Val Asp Leu Arg 
785                 790                 795                 800 


Asn Met Asp Leu Thr Thr Pro Pro Ile Ile Phe Tyr Gln His Thr Ser 
                805                 810                 815     


Glu Ile Glu Ser Leu Asp Val Ser Asn Asn Ala Asn Ile Phe Leu Pro 
            820                 825                 830         


Leu Glu Phe Ile Glu Ser Ser Ile Lys Leu Leu Ser Leu Arg Met Val 
        835                 840                 845             


Asn Ile Arg Ala Ser Lys Phe Pro Ser Asn Ile Thr Lys Ala Tyr Lys 
    850                 855                 860                 


Leu Val Ser Leu Glu Leu Gln Arg Asn Phe Ile Arg Lys Val Pro Asn 
865                 870                 875                 880 


Ser Ile Met Lys Leu Ser Asn Leu Thr Ile Leu Asn Leu Gln Cys Asn 
                885                 890                 895     


Glu Leu Glu Ser Leu Pro Ala Gly Phe Val Glu Leu Lys Asn Leu Gln 
            900                 905                 910         


Leu Leu Asp Leu Ser Ser Asn Lys Phe Met His Tyr Pro Glu Val Ile 
        915                 920                 925             


Asn Tyr Cys Thr Asn Leu Leu Gln Ile Asp Leu Ser Tyr Asn Lys Ile 
    930                 935                 940                 


Gln Ser Leu Pro Gln Ser Thr Lys Tyr Leu Val Lys Leu Ala Lys Met 
945                 950                 955                 960 


Asn Leu Ser His Asn Lys Leu Asn Phe Ile Gly Asp Leu Ser Glu Met 
                965                 970                 975     


Thr Asp Leu Arg Thr Leu Asn Leu Arg Tyr Asn Arg Ile Ser Ser Ile 
            980                 985                 990         


Lys Thr Asn Ala Ser Asn Leu Gln  Asn Leu Phe Leu Thr  Asp Asn Arg 
        995                 1000                 1005             


Ile Ser  Asn Phe Glu Asp Thr  Leu Pro Lys Leu Arg  Ala Leu Glu 
    1010                 1015                 1020             


Ile Gln  Glu Asn Pro Ile Thr  Ser Ile Ser Phe Lys  Asp Phe Tyr 
    1025                 1030                 1035             


Pro Lys  Asn Met Thr Ser Leu  Thr Leu Asn Lys Ala  Gln Leu Ser 
    1040                 1045                 1050             


Ser Ile  Pro Gly Glu Leu Leu  Thr Lys Leu Ser Phe  Leu Glu Lys 
    1055                 1060                 1065             


Leu Glu  Leu Asn Gln Asn Asn  Leu Thr Arg Leu Pro  Gln Glu Ile 
    1070                 1075                 1080             


Ser Lys  Leu Thr Lys Leu Val  Phe Leu Ser Val Ala  Arg Asn Lys 
    1085                 1090                 1095             


Leu Glu  Tyr Ile Pro Pro Glu  Leu Ser Gln Leu Lys  Ser Leu Arg 
    1100                 1105                 1110             


Thr Leu  Asp Leu His Ser Asn  Asn Ile Arg Asp Phe  Val Asp Gly 
    1115                 1120                 1125             


Met Glu  Asn Leu Glu Leu Thr  Ser Leu Asn Ile Ser  Ser Asn Ala 
    1130                 1135                 1140             


Phe Gly  Asn Ser Ser Leu Glu  Asn Ser Phe Tyr His  Asn Met Ser 
    1145                 1150                 1155             


Tyr Gly  Ser Lys Leu Ser Lys  Ser Leu Met Phe Phe  Ile Ala Ala 
    1160                 1165                 1170             


Asp Asn  Gln Phe Asp Asp Ala  Met Trp Pro Leu Phe  Asn Cys Phe 
    1175                 1180                 1185             


Val Asn  Leu Lys Val Leu Asn  Leu Ser Tyr Asn Asn  Phe Ser Asp 
    1190                 1195                 1200             


Val Ser  His Met Lys Leu Glu  Ser Ile Thr Glu Leu  Tyr Leu Ser 
    1205                 1210                 1215             


Gly Asn  Lys Leu Thr Thr Leu  Ser Gly Asp Thr Val  Leu Lys Trp 
    1220                 1225                 1230             


Ser Ser  Leu Lys Thr Leu Met  Leu Asn Ser Asn Gln  Met Leu Ser 
    1235                 1240                 1245             


Leu Pro  Ala Glu Leu Ser Asn  Leu Ser Gln Leu Ser  Val Phe Asp 
    1250                 1255                 1260             


Val Gly  Ala Asn Gln Leu Lys  Tyr Asn Ile Ser Asn  Tyr His Tyr 
    1265                 1270                 1275             


Asp Trp  Asn Trp Arg Asn Asn  Lys Glu Leu Lys Tyr  Leu Asn Phe 
    1280                 1285                 1290             


Ser Gly  Asn Arg Arg Phe Glu  Ile Lys Ser Phe Ile  Ser His Asp 
    1295                 1300                 1305             


Ile Asp  Ala Asp Leu Ser Asp  Leu Thr Val Leu Pro  Gln Leu Lys 
    1310                 1315                 1320             


Val Leu  Gly Leu Met Asp Val  Thr Leu Asn Thr Thr  Lys Val Pro 
    1325                 1330                 1335             


Asp Glu  Asn Val Asn Phe Arg  Leu Arg Thr Thr Ala  Ser Ile Ile 
    1340                 1345                 1350             


Asn Gly  Met Arg Tyr Gly Val  Ala Asp Thr Leu Gly  Gln Arg Asp 
    1355                 1360                 1365             


Tyr Val  Ser Ser Arg Asp Val  Thr Phe Glu Arg Phe  Arg Gly Asn 
    1370                 1375                 1380             


Asp Asp  Glu Cys Leu Leu Cys  Leu His Asp Ser Lys  Asn Gln Asn 
    1385                 1390                 1395             


Ala Asp  Tyr Gly His Asn Ile  Ser Arg Ile Val Arg  Asp Ile Tyr 
    1400                 1405                 1410             


Asp Lys  Ile Leu Ile Arg Gln  Leu Glu Arg Tyr Gly  Asp Glu Thr 
    1415                 1420                 1425             


Asp Asp  Asn Ile Lys Thr Ala  Leu Arg Phe Ser Phe  Leu Gln Leu 
    1430                 1435                 1440             


Asn Lys  Glu Ile Asn Gly Met  Leu Asn Ser Val Asp  Asn Gly Ala 
    1445                 1450                 1455             


Asp Val  Ala Asn Leu Ser Tyr  Ala Asp Leu Leu Ser  Gly Ala Cys 
    1460                 1465                 1470             


Ser Thr  Val Ile Tyr Ile Arg  Gly Lys Lys Leu Phe  Ala Ala Asn 
    1475                 1480                 1485             


Leu Gly  Asp Cys Met Ala Ile  Leu Ser Lys Asn Asn  Gly Asp Tyr 
    1490                 1495                 1500             


Gln Thr  Leu Thr Lys Gln His  Leu Pro Thr Lys Arg  Glu Glu Tyr 
    1505                 1510                 1515             


Glu Arg  Ile Arg Ile Ser Gly  Gly Tyr Val Asn Asn  Gly Lys Leu 
    1520                 1525                 1530             


Asp Gly  Val Val Asp Val Ser  Arg Ala Val Gly Phe  Phe Asp Leu 
    1535                 1540                 1545             


Leu Pro  His Ile His Ala Ser  Pro Asp Ile Ser Val  Val Thr Leu 
    1550                 1555                 1560             


Thr Lys  Ala Asp Glu Met Leu  Ile Val Ala Thr His  Lys Leu Trp 
    1565                 1570                 1575             


Glu Tyr  Met Asp Val Asp Thr  Val Cys Asp Ile Ala  Arg Glu Asn 
    1580                 1585                 1590             


Ser Thr  Asp Pro Leu Arg Ala  Ala Ala Glu Leu Lys  Asp His Ala 
    1595                 1600                 1605             


Met Ala  Tyr Gly Cys Thr Glu  Asn Ile Thr Ile Leu  Cys Leu Ala 
    1610                 1615                 1620             


Leu Tyr  Glu Asn Ile Gln Gln  Gln Asn Arg Phe Thr  Leu Asn Lys 
    1625                 1630                 1635             


Asn Ser  Leu Met Thr Arg Arg  Ser Thr Phe Glu Asp  Thr Thr Leu 
    1640                 1645                 1650             


Arg Arg  Leu Gln Pro Glu Ile  Ser Pro Pro Thr Gly  Asn Leu Ala 
    1655                 1660                 1665             


Met Val  Phe Thr Asp Ile Lys  Ser Ser Thr Phe Leu  Trp Glu Leu 
    1670                 1675                 1680             


Phe Pro  Asn Ala Met Arg Thr  Ala Ile Lys Thr His  Asn Asp Ile 
    1685                 1690                 1695             


Met Arg  Arg Gln Leu Arg Ile  Tyr Gly Gly Tyr Glu  Val Lys Thr 
    1700                 1705                 1710             


Glu Gly  Asp Ala Phe Met Val  Ala Phe Pro Thr Pro  Thr Ser Gly 
    1715                 1720                 1725             


Leu Thr  Trp Cys Leu Ser Val  Gln Leu Lys Leu Leu  Asp Ala Gln 
    1730                 1735                 1740             


Trp Pro  Glu Glu Ile Thr Ser  Val Gln Asp Gly Cys  Gln Val Thr 
    1745                 1750                 1755             


Asp Arg  Asn Gly Asn Ile Ile  Tyr Gln Gly Leu Ser  Val Arg Met 
    1760                 1765                 1770             


Gly Ile  His Trp Gly Cys Pro  Val Pro Glu Leu Asp  Leu Val Thr 
    1775                 1780                 1785             


Gln Arg  Met Asp Tyr Leu Gly  Pro Met Val Asn Lys  Ala Ala Arg 
    1790                 1795                 1800             


Val Gln  Gly Val Ala Asp Gly  Gly Gln Ile Ala Met  Ser Ser Asp 
    1805                 1810                 1815             


Phe Tyr  Ser Glu Phe Asn Lys  Ile Met Lys Tyr His  Glu Arg Val 
    1820                 1825                 1830             


Val Lys  Gly Lys Glu Ser Leu  Lys Glu Val Tyr Gly  Glu Glu Ile 
    1835                 1840                 1845             


Ile Gly  Glu Val Leu Glu Arg  Glu Ile Ala Met Leu  Glu Ser Ile 
    1850                 1855                 1860             


Gly Trp  Ala Phe Phe Asp Phe  Gly Glu His Lys Leu  Lys Gly Leu 
    1865                 1870                 1875             


Glu Thr  Lys Glu Leu Val Thr  Ile Ala Tyr Pro Lys  Ile Leu Ala 
    1880                 1885                 1890             


Ser Arg  His Glu Phe Ala Ser  Glu Asp Glu Gln Ser  Lys Leu Ile 
    1895                 1900                 1905             


Asn Glu  Thr Met Leu Phe Arg  Leu Arg Val Ile Ser  Asn Arg Leu 
    1910                 1915                 1920             


Glu Ser  Ile Met Ser Ala Leu  Ser Gly Gly Phe Ile  Glu Leu Asp 
    1925                 1930                 1935             


Ser Arg  Thr Glu Gly Ser Tyr  Ile Lys Phe Asn Pro  Lys Val Glu 
    1940                 1945                 1950             


Asn Gly  Ile Met Gln Ser Ile  Ser Glu Lys Asp Ala  Leu Leu Phe 
    1955                 1960                 1965             


Phe Asp  His Val Ile Thr Arg  Ile Glu Ser Ser Val  Ala Leu Leu 
    1970                 1975                 1980             


His Leu  Arg Gln Gln Arg Cys  Ser Gly Leu Glu Ile  Cys Arg Asn 
    1985                 1990                 1995             


Asp Lys  Thr Ser Ala Arg Ser  Asn Ile Phe Asn Val  Val Asp Glu 
    2000                 2005                 2010             


Leu Leu  Gln Met Val Lys Asn  Ala Lys Asp Leu Ser  Thr 
    2015                 2020                 2025     


<210>  3
<211>  686
<212>  PRT
<213>  Geobacillus stearothermophilus

<400>  3

Ser Ser Ser Ala Ser Val Lys Gly Asp Val Ile Tyr Gln Ile Ile Ile 
1               5                   10                  15      


Asp Arg Phe Tyr Asp Gly Asp Thr Thr Asn Asn Asn Pro Ala Lys Ser 
            20                  25                  30          


Tyr Gly Leu Tyr Asp Pro Thr Lys Ser Lys Trp Lys Met Tyr Trp Gly 
        35                  40                  45              


Gly Asp Leu Glu Gly Val Arg Gln Lys Leu Pro Tyr Leu Lys Gln Leu 
    50                  55                  60                  


Gly Val Thr Thr Ile Trp Leu Ser Pro Val Leu Asp Asn Leu Asp Thr 
65                  70                  75                  80  


Leu Ala Gly Thr Asp Asn Thr Gly Tyr His Gly Tyr Trp Thr Arg Asp 
                85                  90                  95      


Phe Lys Gln Ile Glu Glu His Phe Gly Asn Trp Thr Thr Phe Asp Thr 
            100                 105                 110         


Leu Val Asn Asp Ala His Gln Asn Gly Ile Lys Val Ile Val Asp Phe 
        115                 120                 125             


Val Pro Asn His Ser Thr Pro Phe Lys Ala Asn Asp Ser Thr Phe Ala 
    130                 135                 140                 


Glu Gly Gly Ala Leu Tyr Asn Asn Gly Thr Tyr Met Gly Asn Tyr Phe 
145                 150                 155                 160 


Asp Asp Ala Thr Lys Gly Tyr Phe His His Asn Gly Asp Ile Ser Asn 
                165                 170                 175     


Trp Asp Asp Arg Tyr Glu Ala Gln Trp Lys Asn Phe Thr Asp Pro Ala 
            180                 185                 190         


Gly Phe Ser Leu Ala Asp Leu Ser Gln Glu Asn Gly Thr Ile Ala Gln 
        195                 200                 205             


Tyr Leu Thr Asp Ala Ala Val Gln Leu Val Ala His Gly Ala Asp Gly 
    210                 215                 220                 


Leu Arg Ile Asp Ala Val Lys His Phe Asn Ser Gly Phe Ser Lys Ser 
225                 230                 235                 240 


Leu Ala Asp Lys Leu Tyr Gln Lys Lys Asp Ile Phe Leu Val Gly Glu 
                245                 250                 255     


Trp Tyr Gly Asp Asp Pro Gly Thr Ala Asn His Leu Glu Lys Val Arg 
            260                 265                 270         


Tyr Ala Asn Asn Ser Gly Val Asn Val Leu Asp Phe Asp Leu Asn Thr 
        275                 280                 285             


Val Ile Arg Asn Val Phe Gly Thr Phe Thr Gln Thr Met Tyr Asp Leu 
    290                 295                 300                 


Asn Asn Met Val Asn Gln Thr Gly Asn Glu Tyr Lys Tyr Lys Glu Asn 
305                 310                 315                 320 


Leu Ile Thr Phe Ile Asp Asn His Asp Met Ser Arg Phe Leu Ser Val 
                325                 330                 335     


Asn Ser Asn Lys Ala Asn Leu His Gln Ala Leu Ala Phe Ile Leu Thr 
            340                 345                 350         


Ser Arg Gly Thr Pro Ser Ile Tyr Tyr Gly Thr Glu Gln Tyr Met Ala 
        355                 360                 365             


Gly Gly Asn Asp Pro Tyr Asn Arg Gly Met Met Pro Ala Phe Asp Thr 
    370                 375                 380                 


Thr Thr Thr Ala Phe Lys Glu Val Ser Thr Leu Ala Gly Leu Arg Arg 
385                 390                 395                 400 


Asn Asn Ala Ala Ile Gln Tyr Gly Thr Thr Thr Gln Arg Trp Ile Asn 
                405                 410                 415     


Asn Asp Val Tyr Ile Tyr Glu Arg Lys Phe Phe Asn Asp Val Val Leu 
            420                 425                 430         


Val Ala Ile Asn Arg Asn Thr Gln Ser Ser Tyr Ser Ile Ser Gly Leu 
        435                 440                 445             


Gln Thr Ala Leu Pro Asn Gly Ser Tyr Ala Asp Tyr Leu Ser Gly Leu 
    450                 455                 460                 


Leu Gly Gly Asn Gly Ile Ser Val Ser Asn Gly Ser Val Ala Ser Phe 
465                 470                 475                 480 


Thr Leu Ala Pro Gly Ala Val Ser Val Trp Gln Tyr Ser Thr Ser Ala 
                485                 490                 495     


Ser Ala Pro Gln Ile Gly Ser Val Ala Pro Asn Met Gly Ile Pro Gly 
            500                 505                 510         


Asn Val Val Thr Ile Asp Gly Lys Gly Phe Gly Thr Thr Gln Gly Thr 
        515                 520                 525             


Val Thr Phe Gly Gly Val Thr Ala Thr Val Lys Ser Trp Thr Ser Asn 
    530                 535                 540                 


Arg Ile Glu Val Tyr Val Pro Asn Met Ala Ala Gly Leu Thr Asp Val 
545                 550                 555                 560 


Lys Val Thr Ala Gly Gly Val Ser Ser Asn Leu Tyr Ser Tyr Asn Ile 
                565                 570                 575     


Leu Ser Gly Thr Gln Thr Ser Val Val Phe Thr Val Lys Ser Ala Pro 
            580                 585                 590         


Pro Thr Asn Leu Gly Asp Lys Ile Tyr Leu Thr Gly Asn Ile Pro Glu 
        595                 600                 605             


Leu Gly Asn Trp Ser Thr Asp Thr Ser Gly Ala Val Asn Asn Ala Gln 
    610                 615                 620                 


Gly Pro Leu Leu Ala Pro Asn Tyr Pro Asp Trp Phe Tyr Val Phe Ser 
625                 630                 635                 640 


Val Pro Ala Gly Lys Thr Ile Gln Phe Lys Phe Phe Ile Lys Arg Ala 
                645                 650                 655     


Asp Gly Thr Ile Gln Trp Glu Asn Gly Ser Asn His Val Ala Thr Thr 
            660                 665                 670         


Pro Thr Gly Ala Thr Gly Asn Ile Thr Val Thr Trp Gln Asn 
        675                 680                 685     


<210>  4
<211>  434
<212>  PRT
<213>  Pyrococcus furiosus

<400>  4

Lys Tyr Leu Glu Leu Glu Glu Gly Gly Val Ile Met Gln Ala Phe Tyr 
1               5                   10                  15      


Trp Asp Val Pro Gly Gly Gly Ile Trp Trp Asp His Ile Arg Ser Lys 
            20                  25                  30          


Ile Pro Glu Trp Tyr Glu Ala Gly Ile Ser Ala Ile Trp Leu Pro Pro 
        35                  40                  45              


Pro Ser Lys Gly Met Ser Gly Gly Tyr Ser Met Gly Tyr Asp Pro Tyr 
    50                  55                  60                  


Asp Tyr Phe Asp Leu Gly Glu Tyr Tyr Gln Lys Gly Thr Val Glu Thr 
65                  70                  75                  80  


Arg Phe Gly Ser Lys Glu Glu Leu Val Arg Leu Ile Gln Thr Ala His 
                85                  90                  95      


Ala Tyr Gly Ile Lys Val Ile Ala Asp Val Val Ile Asn His Arg Ala 
            100                 105                 110         


Gly Gly Asp Leu Glu Trp Asn Pro Phe Val Gly Asp Tyr Thr Trp Thr 
        115                 120                 125             


Asp Phe Ser Lys Val Ala Ser Gly Lys Tyr Thr Ala Asn Tyr Leu Asp 
    130                 135                 140                 


Phe His Pro Asn Glu Leu His Cys Cys Asp Glu Gly Thr Phe Gly Gly 
145                 150                 155                 160 


Phe Pro Asp Ile Cys His His Lys Glu Trp Asp Gln Tyr Trp Leu Trp 
                165                 170                 175     


Lys Ser Asn Glu Ser Tyr Ala Ala Tyr Leu Arg Ser Ile Gly Phe Asp 
            180                 185                 190         


Gly Trp Arg Phe Asp Tyr Val Lys Gly Tyr Gly Ala Trp Val Val Arg 
        195                 200                 205             


Asp Trp Leu Asn Trp Trp Gly Gly Trp Ala Val Gly Glu Tyr Trp Asp 
    210                 215                 220                 


Thr Asn Val Asp Ala Leu Leu Ser Trp Ala Tyr Glu Ser Gly Ala Lys 
225                 230                 235                 240 


Val Phe Asp Phe Pro Leu Tyr Tyr Lys Met Asp Glu Ala Phe Asp Asn 
                245                 250                 255     


Asn Asn Ile Pro Ala Leu Val Tyr Ala Leu Gln Asn Gly Gln Thr Val 
            260                 265                 270         


Val Ser Arg Asp Pro Phe Lys Ala Val Thr Phe Val Ala Asn His Asp 
        275                 280                 285             


Thr Asp Ile Ile Trp Asn Lys Tyr Pro Ala Tyr Ala Phe Ile Leu Thr 
    290                 295                 300                 


Tyr Glu Gly Gln Pro Val Ile Phe Tyr Arg Asp Phe Glu Glu Trp Leu 
305                 310                 315                 320 


Asn Lys Asp Lys Leu Ile Asn Leu Ile Trp Ile His Asp His Leu Ala 
                325                 330                 335     


Gly Gly Ser Thr Thr Ile Val Tyr Tyr Asp Asn Asp Glu Leu Ile Phe 
            340                 345                 350         


Val Arg Asn Gly Asp Ser Arg Arg Pro Gly Leu Ile Thr Tyr Ile Asn 
        355                 360                 365             


Leu Ser Pro Asn Trp Val Gly Arg Trp Val Tyr Val Pro Lys Phe Ala 
    370                 375                 380                 


Gly Ala Cys Ile His Glu Tyr Thr Gly Asn Leu Gly Gly Trp Val Asp 
385                 390                 395                 400 


Lys Arg Val Asp Ser Ser Gly Trp Val Tyr Leu Glu Ala Pro Pro His 
                405                 410                 415     


Asp Pro Ala Asn Gly Tyr Tyr Gly Tyr Ser Val Trp Ser Tyr Cys Gly 
            420                 425                 430         


Val Gly 
        


<210>  5
<211>  6105
<212>  DNA
<213>  Saccharomyces cerevisiae

<400>  5
atgtcatcaa aacctgatac tggttcggaa atttctggcc ctcagcgaca ggaagaacaa       60

gaacaacaga tagagcagag ctcacctacg gaagcaaacg atagaagcat tcatgatgag      120

gtaccaaaag tcaagaagcg tcacgaacaa aatagtggtc acaaatcaag aaggaatagc      180

gcatatagtt attacagccc acggtcgctt tctatgacca aaagcaggga gagtatcact      240

ccaaatggta tggatgatgt aagtatttcg aacgtggaac atccaaggcc gacagaaccg      300

aaaatcaaaa ggggtccata tttactgaag aaaacattga gcagtctttc aatgacgagc      360

gcgaatagta ctcatgatga taataaagac cacggttacg ctttgaattc atccaagacg      420

cacaactaca catctactca taaccatcat gacggtcatc atgatcatca tcatgttcag      480

ttttttccca ataggaagcc atcattagcg gaaaccctat tcaaaaggtt ttcagggtca      540

aacagtcacg atggcaataa gtcaggaaag gaaagtaaag ttgctaacct ttccctttca      600

acggtaaatc ctgcacctgc taataggaaa ccttctaaag actccacttt atctaatcac      660

ttggctgata acgtgccaag cactttacga aggaaagtgt cctcattggt acgtggttct      720

tccgtccatg atataaataa tggtattgca gataaacaga ttagaccaaa gactgttgcg      780

caatcagaaa atacattaca ttcatccgat gttcccaata gcaaacgctc gcacagaaaa      840

agctttctgc taggctccac atcttcttca agcagtagaa gaggttcaaa tgtcagttca      900

atgactaaca gtgacagtgc aagtatggcg acgtcgggta gtcatgttct ccaacataac      960

gtatctaatg tttctccaac tactaaaagt aaggacagcg ttaacagcga atccgccgat     1020

cacactaata ataaatccga gaaagtgact ccagaatata atgagaacat tccggaaaat     1080

tctaactctg acaacaaacg cgaagccaca acgcctacta tagaaacacc catttcatgt     1140

aaaccatccc ttttcaggct agatacaaac cttgaggatg ttactgatat tacaaagacg     1200

gtgccaccca ccgctgtcaa ttctacacta aattctacac acgggactga gactgcctca     1260

cccaaaacgg tgatcatgcc tgaaggtcct aggaagtcgg tgtcaatggc tgatctctcc     1320

gtcgctgccg cagcacctaa tggtgaattc acatcaactt ccaatgatag atcacaatgg     1380

gtagcacctc aaagctggga tgtggaaacc aaaaggaaaa aaacaaaacc taaagggaga     1440

tcgaaatcaa gaaggtcaag tatagatgct gatgaacttg atcccatgtc accggggcca     1500

ccttcaaaaa aagactctcg tcatcgtaag aaccgacact ctcgtcatca tcacgatcga     1560

aaggataacg aatcaatggt cactgcgggt gacagtaact caagttttgt tgatatatgt     1620

aaagaaaacg ttccgaatga tagcaagacc gcactcgata ctaaatctgt gaaccgctta     1680

aaaagtaatt tggctatgag tcccccaagt atacgatatg ctccatcaaa tttagatggg     1740

gactacgaca cgtcttccac ttcctcatct ttaccgtcct catctattag ttcagaagat     1800

acatcttcct gcagcgattc ctcttcgtac actaacgcgt atatggaggc caaccgagag     1860

caggataata aaacaccgat cctgaataaa acgaaatcgt ataccaagaa atttacatcc     1920

tcttcggtaa atatgaattc accagatggt gcccagagtt ctggattatt actacaagat     1980

gagaaggacg atgaggtcga gtgccaactg gaacattact ataaagattt cagtgattta     2040

gatccaaaga ggcactatgc tattcgtata ttcaatactg atgacacttt tacgactctc     2100

tcatgtactc cagcgactac cgtcgaagag ataatacctg cacttaaaag aaaatttaac     2160

attacagcgc aagggaattt tcaaatttcc ctgaaggtgg gaaagttgtc aaaaattttg     2220

agaccaactt cgaaacctat tttaattgaa agaaaacttt tacttttgaa tggttatcga     2280

aagtcagacc cacttcatat tatgggtata gaggatttaa gttttgtttt taagtttctt     2340

ttccatcctg tcacaccttc tcactttact cctgaacaag aacaaagaat aatgagaagc     2400

gaatttgttc acgtagattt aaggaatatg gatctgacta cacctcccat cattttttac     2460

cagcatacgt cagaaataga aagtttagac gtttctaata acgtaaatat attcctacct     2520

ctggagttca ttgaaagctc gattaaatta ttaagtttga gaatggttaa tattagagca     2580

tctaaatttc cttccaatat cactaaggcg tataaactag tatctttgga attacagaga     2640

aacttcataa gaaaagtacc gaactcaatc atgaaactga gtaatttaac gatattaaac     2700

cttcaatgta atgagcttga aagcctaccg gctggatttg ttgaactgaa aaatctgcaa     2760

ttgctagact tgtcttcaaa caagttcatg cactacccag aagttattaa ctactgcacc     2820

aatcttttac aaatagacct atcatataat aaaatccaaa gcttaccaca gtccactaag     2880

tacctagtaa agcttgcgaa gatgaacctt tctcataaca aactaaattt tataggcgac     2940

ttatcggaaa tgacaaattt gaggacgctg aacctaagat ataacagaat atcatcaatt     3000

aagacaaatg cgtctaactt gcagaacctt tttttaacag ataatagaat ttcgaacttt     3060

gaagacactt tgccgaaact aagagccctt gaaattcaag agaatccaat cacttctata     3120

tccttcaaag atttttatcc aaaaaacatg acaagtttga cgttgaacaa ggcacagtta     3180

tcgagtattc ctggagaatt actcaccaaa ctatctttcc tcgagaaact tgaacttaat     3240

cagaataatt tgactagact gccacaggag atatccaagt tgactaaatt agttttcctt     3300

tcagtggcga gaaacaaact agagtatatt ccacccgagc tatctcaact gaaaagtttg     3360

aggacattag atctacattc taacaacata agggactttg ttgacggtat ggaaaacctt     3420

gaactaacat cgctaaatat ttcatcgaat gcattcggta actctagctt agaaaattct     3480

ttttaccata acatgtcata tgggtcaaag ttatctaaaa gcctgatgtt ttttattgct     3540

gcagacaatc aatttgatga tgctatgtgg cctcttttca attgctttgt caatctgaaa     3600

gtgctaaatc tttcttacaa caatttttca gatgtatcgc acatgaaact tgagagcatt     3660

accgaattgt acctctccgg taataagctc acgacattgt cgggtgatac agttttgaaa     3720

tggagctctt taaagacttt aatgttgaat agtaaccaaa tgttatctct gcctgcagaa     3780

ttatcaaatc tctcacagct aagtgtattt gatgttggag caaatcaatt aaagtataat     3840

atatcaaact atcattacga ttggaactgg aggaataata aagaactaaa atatttgaat     3900

ttttcaggaa atcgaaggtt tgaaataaag tcatttataa gtcacgatat tgatgctgat     3960

ttgtcagatc tgacagtatt acctcagtta aaggtactag gtttaatgga cgtaacttta     4020

aatactacca aagtaccgga tgaaaatgtc aatttccgtt taaggacaac tgcatcaata     4080

ataaatggga tgcgctacgg tgttgctgat acattaggtc aaagagacta tgtgtcatct     4140

cgtgatgtta cctttgaaag attccgcgga aatgacgacg aatgcttact atgtcttcat     4200

gatagtaaaa accaaaatgc agattatggc cacaatatat caagaattgt tagagatatt     4260

tacgataaaa tactgatcag acaactggaa aggtatggag acgaaacaga tgataatata     4320

aaaactgcac ttcgtttcag ttttttgcaa ctgaataagg agattaacgg aatgctaaat     4380

tctgttgata atggtgccga tgttgccaat ctttcatatg cagacttgct aagtggcgct     4440

tgctctactg tgatatatat cagagggaag aaactcttcg ctgcaaattt aggtgactgt     4500

atggctattt tatccaaaaa caatggtgac taccaaacgc taaccaaaca acatctccca     4560

acaaagcggg aagaatacga gaggatcaga atatctggcg ggtatgtcaa caatggaaaa     4620

ttagatggtg ttgtagatgt gtctagagca gtgggttttt ttgatttgct tccccacatt     4680

catgcttctc ccgacatatc tgtcgtgaca ttaacaaaag cagacgagat gcttattgta     4740

gcaacgcata agttatggga atacatggac gtggatacag tttgtgatat cgcgcgtgag     4800

aatagtactg atccactccg tgccgcagct gagttgaagg atcatgccat ggcttacggc     4860

tgtacagaga atattacaat tttgtgcctt gctctttacg agaacattca gcaacaaaat     4920

cggttcactt taaataaaaa ctctttaatg actagaagaa gtactttcga ggatactaca     4980

ttaagaagac ttcaacctga gatttctccg ccaacaggta acctagcaat ggtcttcact     5040

gatatcaaaa gctcaacctt cttatgggag ctattcccta acgcaatgag gaccgcaata     5100

aaaactcaca atgacattat gcgtcgtcaa ctacgaattt acggtggtta cgaagtaaag     5160

acagaaggag acgcctttat ggtggcattt cctacgccaa ctagtggtct gacatggtgc     5220

ttaagtgttc aattaaaact cttggatgca caatggccgg aggaaattac ctcagttcaa     5280

gacggctgcc aagttacgga tagaaatggt aacattatct atcaaggcct atcagttaga     5340

atgggtattc attggggctg cccagttcca gagcttgatt tagtgactca aagaatggac     5400

tatttggggc cgatggtcaa taaggcagca agggtccagg gcgtcgctga cggtggtcag     5460

attgcaatga gtagtgattt ttactctgaa ttcaacaaga taatgaagta tcatgagcga     5520

gtagtgaagg gcaaggaatc tctcaaggaa gtttatggtg aagaaattat cggagaggtt     5580

cttgaaagag aaattgccat gctggaaagt attggttggg cattttttga ctttggcgag     5640

cataagctaa agggactcga aaccaaagaa ctcgttacta ttgcgtatcc taagattctt     5700

gcttccagac acgaatttgc atctgaagat gagcagtcaa aattaatcaa tgaaacgatg     5760

ttgtttcgtt taagagtcat ttcaaacaga ctggaatcta taatgtcagc tttaagcggc     5820

ggatttattg aactagactc tcggacggag ggaagttata ttaaatttaa ccctaaagtt     5880

gaaaatggta ttatgcaatc gatttctgag aaggatgcgt tgttattttt tgatcatgta     5940

attactagaa tcgaatccag tgtggcatta ttacatttac gacaacagag gtgttcagga     6000

ctggaaattt gcagaaacga taaaacatct gctcgaagca atattttcaa tgttgttgac     6060

gaacttttac aaatggttaa gaacgcaaag gatttatcaa cttga                     6105


<210>  6
<211>  2034
<212>  PRT
<213>  Saccharomyces cerevisiae

<400>  6

Met Ser Ser Lys Pro Asp Thr Gly Ser Glu Ile Ser Gly Pro Gln Arg 
1               5                   10                  15      


Gln Glu Glu Gln Glu Gln Gln Ile Glu Gln Ser Ser Pro Thr Glu Ala 
            20                  25                  30          


Asn Asp Arg Ser Ile His Asp Glu Val Pro Lys Val Lys Lys Arg His 
        35                  40                  45              


Glu Gln Asn Ser Gly His Lys Ser Arg Arg Asn Ser Ala Tyr Ser Tyr 
    50                  55                  60                  


Tyr Ser Pro Arg Ser Leu Ser Met Thr Lys Ser Arg Glu Ser Ile Thr 
65                  70                  75                  80  


Pro Asn Gly Met Asp Asp Val Ser Ile Ser Asn Val Glu His Pro Arg 
                85                  90                  95      


Pro Thr Glu Pro Lys Ile Lys Arg Gly Pro Tyr Leu Leu Lys Lys Thr 
            100                 105                 110         


Leu Ser Ser Leu Ser Met Thr Ser Ala Asn Ser Thr His Asp Asp Asn 
        115                 120                 125             


Lys Asp His Gly Tyr Ala Leu Asn Ser Ser Lys Thr His Asn Tyr Thr 
    130                 135                 140                 


Ser Thr His Asn His His Asp Gly His His Asp His His His Val Gln 
145                 150                 155                 160 


Phe Phe Pro Asn Arg Lys Pro Ser Leu Ala Glu Thr Leu Phe Lys Arg 
                165                 170                 175     


Phe Ser Gly Ser Asn Ser His Asp Gly Asn Lys Ser Gly Lys Glu Ser 
            180                 185                 190         


Lys Val Ala Asn Leu Ser Leu Ser Thr Val Asn Pro Ala Pro Ala Asn 
        195                 200                 205             


Arg Lys Pro Ser Lys Asp Ser Thr Leu Ser Asn His Leu Ala Asp Asn 
    210                 215                 220                 


Val Pro Ser Thr Leu Arg Arg Lys Val Ser Ser Leu Val Arg Gly Ser 
225                 230                 235                 240 


Ser Val His Asp Ile Asn Asn Gly Ile Ala Asp Lys Gln Ile Arg Pro 
                245                 250                 255     


Lys Thr Val Ala Gln Ser Glu Asn Thr Leu His Ser Ser Asp Val Pro 
            260                 265                 270         


Asn Ser Lys Arg Ser His Arg Lys Ser Phe Leu Leu Gly Ser Thr Ser 
        275                 280                 285             


Ser Ser Ser Ser Arg Arg Gly Ser Asn Val Ser Ser Met Thr Asn Ser 
    290                 295                 300                 


Asp Ser Ala Ser Met Ala Thr Ser Gly Ser His Val Leu Gln His Asn 
305                 310                 315                 320 


Val Ser Asn Val Ser Pro Thr Thr Lys Ser Lys Asp Ser Val Asn Ser 
                325                 330                 335     


Glu Ser Ala Asp His Thr Asn Asn Lys Ser Glu Lys Val Thr Pro Glu 
            340                 345                 350         


Tyr Asn Glu Asn Ile Pro Glu Asn Ser Asn Ser Asp Asn Lys Arg Glu 
        355                 360                 365             


Ala Thr Thr Pro Thr Ile Glu Thr Pro Ile Ser Cys Lys Pro Ser Leu 
    370                 375                 380                 


Phe Arg Leu Asp Thr Asn Leu Glu Asp Val Thr Asp Ile Thr Lys Thr 
385                 390                 395                 400 


Val Pro Pro Thr Ala Val Asn Ser Thr Leu Asn Ser Thr His Gly Thr 
                405                 410                 415     


Glu Thr Ala Ser Pro Lys Thr Val Ile Met Pro Glu Gly Pro Arg Lys 
            420                 425                 430         


Ser Val Ser Met Ala Asp Leu Ser Val Ala Ala Ala Ala Pro Asn Gly 
        435                 440                 445             


Glu Phe Thr Ser Thr Ser Asn Asp Arg Ser Gln Trp Val Ala Pro Gln 
    450                 455                 460                 


Ser Trp Asp Val Glu Thr Lys Arg Lys Lys Thr Lys Pro Lys Gly Arg 
465                 470                 475                 480 


Ser Lys Ser Arg Arg Ser Ser Ile Asp Ala Asp Glu Leu Asp Pro Met 
                485                 490                 495     


Ser Pro Gly Pro Pro Ser Lys Lys Asp Ser Arg His Arg Lys Asn Arg 
            500                 505                 510         


His Ser Arg His His His Asp Arg Lys Asp Asn Glu Ser Met Val Thr 
        515                 520                 525             


Ala Gly Asp Ser Asn Ser Ser Phe Val Asp Ile Cys Lys Glu Asn Val 
    530                 535                 540                 


Pro Asn Asp Ser Lys Thr Ala Leu Asp Thr Lys Ser Val Asn Arg Leu 
545                 550                 555                 560 


Lys Ser Asn Leu Ala Met Ser Pro Pro Ser Ile Arg Tyr Ala Pro Ser 
                565                 570                 575     


Asn Leu Asp Gly Asp Tyr Asp Thr Ser Ser Thr Ser Ser Ser Leu Pro 
            580                 585                 590         


Ser Ser Ser Ile Ser Ser Glu Asp Thr Ser Ser Cys Ser Asp Ser Ser 
        595                 600                 605             


Ser Tyr Thr Asn Ala Tyr Met Glu Ala Asn Arg Glu Gln Asp Asn Lys 
    610                 615                 620                 


Thr Pro Ile Leu Asn Lys Thr Lys Ser Tyr Thr Lys Lys Phe Thr Ser 
625                 630                 635                 640 


Ser Ser Val Asn Met Asn Ser Pro Asp Gly Ala Gln Ser Ser Gly Leu 
                645                 650                 655     


Leu Leu Gln Asp Glu Lys Asp Asp Glu Val Glu Cys Gln Leu Glu His 
            660                 665                 670         


Tyr Tyr Lys Asp Phe Ser Asp Leu Asp Pro Lys Arg His Tyr Ala Ile 
        675                 680                 685             


Arg Ile Phe Asn Thr Asp Asp Thr Phe Thr Thr Leu Ser Cys Thr Pro 
    690                 695                 700                 


Ala Thr Thr Val Glu Glu Ile Ile Pro Ala Leu Lys Arg Lys Phe Asn 
705                 710                 715                 720 


Ile Thr Ala Gln Gly Asn Phe Gln Ile Ser Leu Lys Val Gly Lys Leu 
                725                 730                 735     


Ser Lys Ile Leu Arg Pro Thr Ser Lys Pro Ile Leu Ile Glu Arg Lys 
            740                 745                 750         


Leu Leu Leu Leu Asn Gly Tyr Arg Lys Ser Asp Pro Leu His Ile Met 
        755                 760                 765             


Gly Ile Glu Asp Leu Ser Phe Val Phe Lys Phe Leu Phe His Pro Val 
    770                 775                 780                 


Thr Pro Ser His Phe Thr Pro Glu Gln Glu Gln Arg Ile Met Arg Ser 
785                 790                 795                 800 


Glu Phe Val His Val Asp Leu Arg Asn Met Asp Leu Thr Thr Pro Pro 
                805                 810                 815     


Ile Ile Phe Tyr Gln His Thr Ser Glu Ile Glu Ser Leu Asp Val Ser 
            820                 825                 830         


Asn Asn Val Asn Ile Phe Leu Pro Leu Glu Phe Ile Glu Ser Ser Ile 
        835                 840                 845             


Lys Leu Leu Ser Leu Arg Met Val Asn Ile Arg Ala Ser Lys Phe Pro 
    850                 855                 860                 


Ser Asn Ile Thr Lys Ala Tyr Lys Leu Val Ser Leu Glu Leu Gln Arg 
865                 870                 875                 880 


Asn Phe Ile Arg Lys Val Pro Asn Ser Ile Met Lys Leu Ser Asn Leu 
                885                 890                 895     


Thr Ile Leu Asn Leu Gln Cys Asn Glu Leu Glu Ser Leu Pro Ala Gly 
            900                 905                 910         


Phe Val Glu Leu Lys Asn Leu Gln Leu Leu Asp Leu Ser Ser Asn Lys 
        915                 920                 925             


Phe Met His Tyr Pro Glu Val Ile Asn Tyr Cys Thr Asn Leu Leu Gln 
    930                 935                 940                 


Ile Asp Leu Ser Tyr Asn Lys Ile Gln Ser Leu Pro Gln Ser Thr Lys 
945                 950                 955                 960 


Tyr Leu Val Lys Leu Ala Lys Met Asn Leu Ser His Asn Lys Leu Asn 
                965                 970                 975     


Phe Ile Gly Asp Leu Ser Glu Met Thr Asn Leu Arg Thr Leu Asn Leu 
            980                 985                 990         


Arg Tyr Asn Arg Ile Ser Ser Ile  Lys Thr Asn Ala Ser  Asn Leu Gln 
        995                 1000                 1005             


Asn Leu  Phe Leu Thr Asp Asn  Arg Ile Ser Asn Phe  Glu Asp Thr 
    1010                 1015                 1020             


Leu Pro  Lys Leu Arg Ala Leu  Glu Ile Gln Glu Asn  Pro Ile Thr 
    1025                 1030                 1035             


Ser Ile  Ser Phe Lys Asp Phe  Tyr Pro Lys Asn Met  Thr Ser Leu 
    1040                 1045                 1050             


Thr Leu  Asn Lys Ala Gln Leu  Ser Ser Ile Pro Gly  Glu Leu Leu 
    1055                 1060                 1065             


Thr Lys  Leu Ser Phe Leu Glu  Lys Leu Glu Leu Asn  Gln Asn Asn 
    1070                 1075                 1080             


Leu Thr  Arg Leu Pro Gln Glu  Ile Ser Lys Leu Thr  Lys Leu Val 
    1085                 1090                 1095             


Phe Leu  Ser Val Ala Arg Asn  Lys Leu Glu Tyr Ile  Pro Pro Glu 
    1100                 1105                 1110             


Leu Ser  Gln Leu Lys Ser Leu  Arg Thr Leu Asp Leu  His Ser Asn 
    1115                 1120                 1125             


Asn Ile  Arg Asp Phe Val Asp  Gly Met Glu Asn Leu  Glu Leu Thr 
    1130                 1135                 1140             


Ser Leu  Asn Ile Ser Ser Asn  Ala Phe Gly Asn Ser  Ser Leu Glu 
    1145                 1150                 1155             


Asn Ser  Phe Tyr His Asn Met  Ser Tyr Gly Ser Lys  Leu Ser Lys 
    1160                 1165                 1170             


Ser Leu  Met Phe Phe Ile Ala  Ala Asp Asn Gln Phe  Asp Asp Ala 
    1175                 1180                 1185             


Met Trp  Pro Leu Phe Asn Cys  Phe Val Asn Leu Lys  Val Leu Asn 
    1190                 1195                 1200             


Leu Ser  Tyr Asn Asn Phe Ser  Asp Val Ser His Met  Lys Leu Glu 
    1205                 1210                 1215             


Ser Ile  Thr Glu Leu Tyr Leu  Ser Gly Asn Lys Leu  Thr Thr Leu 
    1220                 1225                 1230             


Ser Gly  Asp Thr Val Leu Lys  Trp Ser Ser Leu Lys  Thr Leu Met 
    1235                 1240                 1245             


Leu Asn  Ser Asn Gln Met Leu  Ser Leu Pro Ala Glu  Leu Ser Asn 
    1250                 1255                 1260             


Leu Ser  Gln Leu Ser Val Phe  Asp Val Gly Ala Asn  Gln Leu Lys 
    1265                 1270                 1275             


Tyr Asn  Ile Ser Asn Tyr His  Tyr Asp Trp Asn Trp  Arg Asn Asn 
    1280                 1285                 1290             


Lys Glu  Leu Lys Tyr Leu Asn  Phe Ser Gly Asn Arg  Arg Phe Glu 
    1295                 1300                 1305             


Ile Lys  Ser Phe Ile Ser His  Asp Ile Asp Ala Asp  Leu Ser Asp 
    1310                 1315                 1320             


Leu Thr  Val Leu Pro Gln Leu  Lys Val Leu Gly Leu  Met Asp Val 
    1325                 1330                 1335             


Thr Leu  Asn Thr Thr Lys Val  Pro Asp Glu Asn Val  Asn Phe Arg 
    1340                 1345                 1350             


Leu Arg  Thr Thr Ala Ser Ile  Ile Asn Gly Met Arg  Tyr Gly Val 
    1355                 1360                 1365             


Ala Asp  Thr Leu Gly Gln Arg  Asp Tyr Val Ser Ser  Arg Asp Val 
    1370                 1375                 1380             


Thr Phe  Glu Arg Phe Arg Gly  Asn Asp Asp Glu Cys  Leu Leu Cys 
    1385                 1390                 1395             


Leu His  Asp Ser Lys Asn Gln  Asn Ala Asp Tyr Gly  His Asn Ile 
    1400                 1405                 1410             


Ser Arg  Ile Val Arg Asp Ile  Tyr Asp Lys Ile Leu  Ile Arg Gln 
    1415                 1420                 1425             


Leu Glu  Arg Tyr Gly Asp Glu  Thr Asp Asp Asn Ile  Lys Thr Ala 
    1430                 1435                 1440             


Leu Arg  Phe Ser Phe Leu Gln  Leu Asn Lys Glu Ile  Asn Gly Met 
    1445                 1450                 1455             


Leu Asn  Ser Val Asp Asn Gly  Ala Asp Val Ala Asn  Leu Ser Tyr 
    1460                 1465                 1470             


Ala Asp  Leu Leu Ser Gly Ala  Cys Ser Thr Val Ile  Tyr Ile Arg 
    1475                 1480                 1485             


Gly Lys  Lys Leu Phe Ala Ala  Asn Leu Gly Asp Cys  Met Ala Ile 
    1490                 1495                 1500             


Leu Ser  Lys Asn Asn Gly Asp  Tyr Gln Thr Leu Thr  Lys Gln His 
    1505                 1510                 1515             


Leu Pro  Thr Lys Arg Glu Glu  Tyr Glu Arg Ile Arg  Ile Ser Gly 
    1520                 1525                 1530             


Gly Tyr  Val Asn Asn Gly Lys  Leu Asp Gly Val Val  Asp Val Ser 
    1535                 1540                 1545             


Arg Ala  Val Gly Phe Phe Asp  Leu Leu Pro His Ile  His Ala Ser 
    1550                 1555                 1560             


Pro Asp  Ile Ser Val Val Thr  Leu Thr Lys Ala Asp  Glu Met Leu 
    1565                 1570                 1575             


Ile Val  Ala Thr His Lys Leu  Trp Glu Tyr Met Asp  Val Asp Thr 
    1580                 1585                 1590             


Val Cys  Asp Ile Ala Arg Glu  Asn Ser Thr Asp Pro  Leu Arg Ala 
    1595                 1600                 1605             


Ala Ala  Glu Leu Lys Asp His  Ala Met Ala Tyr Gly  Cys Thr Glu 
    1610                 1615                 1620             


Asn Ile  Thr Ile Leu Cys Leu  Ala Leu Tyr Glu Asn  Ile Gln Gln 
    1625                 1630                 1635             


Gln Asn  Arg Phe Thr Leu Asn  Lys Asn Ser Leu Met  Thr Arg Arg 
    1640                 1645                 1650             


Ser Thr  Phe Glu Asp Thr Thr  Leu Arg Arg Leu Gln  Pro Glu Ile 
    1655                 1660                 1665             


Ser Pro  Pro Thr Gly Asn Leu  Ala Met Val Phe Thr  Asp Ile Lys 
    1670                 1675                 1680             


Ser Ser  Thr Phe Leu Trp Glu  Leu Phe Pro Asn Ala  Met Arg Thr 
    1685                 1690                 1695             


Ala Ile  Lys Thr His Asn Asp  Ile Met Arg Arg Gln  Leu Arg Ile 
    1700                 1705                 1710             


Tyr Gly  Gly Tyr Glu Val Lys  Thr Glu Gly Asp Ala  Phe Met Val 
    1715                 1720                 1725             


Ala Phe  Pro Thr Pro Thr Ser  Gly Leu Thr Trp Cys  Leu Ser Val 
    1730                 1735                 1740             


Gln Leu  Lys Leu Leu Asp Ala  Gln Trp Pro Glu Glu  Ile Thr Ser 
    1745                 1750                 1755             


Val Gln  Asp Gly Cys Gln Val  Thr Asp Arg Asn Gly  Asn Ile Ile 
    1760                 1765                 1770             


Tyr Gln  Gly Leu Ser Val Arg  Met Gly Ile His Trp  Gly Cys Pro 
    1775                 1780                 1785             


Val Pro  Glu Leu Asp Leu Val  Thr Gln Arg Met Asp  Tyr Leu Gly 
    1790                 1795                 1800             


Pro Met  Val Asn Lys Ala Ala  Arg Val Gln Gly Val  Ala Asp Gly 
    1805                 1810                 1815             


Gly Gln  Ile Ala Met Ser Ser  Asp Phe Tyr Ser Glu  Phe Asn Lys 
    1820                 1825                 1830             


Ile Met  Lys Tyr His Glu Arg  Val Val Lys Gly Lys  Glu Ser Leu 
    1835                 1840                 1845             


Lys Glu  Val Tyr Gly Glu Glu  Ile Ile Gly Glu Val  Leu Glu Arg 
    1850                 1855                 1860             


Glu Ile  Ala Met Leu Glu Ser  Ile Gly Trp Ala Phe  Phe Asp Phe 
    1865                 1870                 1875             


Gly Glu  His Lys Leu Lys Gly  Leu Glu Thr Lys Glu  Leu Val Thr 
    1880                 1885                 1890             


Ile Ala  Tyr Pro Lys Ile Leu  Ala Ser Arg His Glu  Phe Ala Ser 
    1895                 1900                 1905             


Glu Asp  Glu Gln Ser Lys Leu  Ile Asn Glu Thr Met  Leu Phe Arg 
    1910                 1915                 1920             


Leu Arg  Val Ile Ser Asn Arg  Leu Glu Ser Ile Met  Ser Ala Leu 
    1925                 1930                 1935             


Ser Gly  Gly Phe Ile Glu Leu  Asp Ser Arg Thr Glu  Gly Ser Tyr 
    1940                 1945                 1950             


Ile Lys  Phe Asn Pro Lys Val  Glu Asn Gly Ile Met  Gln Ser Ile 
    1955                 1960                 1965             


Ser Glu  Lys Asp Ala Leu Leu  Phe Phe Asp His Val  Ile Thr Arg 
    1970                 1975                 1980             


Ile Glu  Ser Ser Val Ala Leu  Leu His Leu Arg Gln  Gln Arg Cys 
    1985                 1990                 1995             


Ser Gly  Leu Glu Ile Cys Arg  Asn Asp Lys Thr Ser  Ala Arg Ser 
    2000                 2005                 2010             


Asn Ile  Phe Asn Val Val Asp  Glu Leu Leu Gln Met  Val Lys Asn 
    2015                 2020                 2025             


Ala Lys  Asp Leu Ser Thr 
    2030                 


<210>  7
<211>  6105
<212>  DNA
<213>  Saccharomyces cerevisiae

<400>  7
atgtcatcaa aacctgatac tggttcggaa atttctggcc ctcagcgaca ggaagaacaa       60

gaacaacaga tagagcagag ctcgcctacg gaagcaaacg atagaagcat tcatgatgag      120

gtaccaaaag tcaagaagcg tcacgaacaa aatagtggtc acaaatcaag aaggaatagc      180

gcatatagtt attacagccc acggtcgctt tctatgacca aaagcaggga gagtatcact      240

ccaaatggta tggatgatgt aagtatttcg aacgtggaac atccaaggcc gacagaaccg      300

aaaatcaaaa ggggtccata tttactgaag aaaacattga gcagtctttc aatgacgagc      360

gcgaatagta ctcatgatga taataaagac cacggttacg ctttgaattc atccaagacg      420

cacaactaca catctactca taaccatcat gacggtcatc atgatcatca tcatgttcag      480

ttttttccca ataggaagcc atcattagcg gaaaccctat tcaaaaggtt ttcagggtca      540

aacagtcacg atggcaataa gtcaggaaag gaaagtaaag ttgctaacct ttccctttca      600

acggtaaatc ctgcacctgc taataggaaa ccttctaaag actccacttt atctaatcac      660

ttggctgata acgtgccaag cactttacga aggaaagtgt cctcattggt acgtggttct      720

tccgtccatg atataaataa tggtattgca gataaacaga ttagaccaaa ggctgttgcg      780

caatcagaaa atacattaca ttcatccgat gttcccaata gcaaacgctc gcacagaaaa      840

agctttctgc taggctccac atcttcttca agcagtagaa gaggttcaaa tgtcagttca      900

atgactaaca gtgacagtgc aagtatggcg acgtcgggta gtcatgttct ccaacataac      960

gtatctaatg tttctccaac tactaaaagt aaggacagcg ttaacagcga atccgccgat     1020

cacactaata ataaatccga gaaagtgact ccagaatata atgagaacat tccggaaaat     1080

tctaactctg acaacaaacg cgaagccaca acgcctacta tagaaacacc catttcatgt     1140

aaaccatccc ttttcaggct agatacaaac cttgaggatg ttactgatat tacaaagacg     1200

gtgccaccca ccgctgtcaa ttctacacta aattctacac acgggactga gactgcctca     1260

cccaaaacgg tgatcatgcc tgaaggtcct aggaagtcgg tgtcaatggc tgatctctcc     1320

gtcgctgccg cagcacctaa tggtgaattc acatcaactt ccaatgatag atcacaatgg     1380

gtagcacctc aaagctggga tgtggaaacc aaaaggaaaa aaacaaaacc taaagggaga     1440

tcgaaatcaa gaaggtcaag tatagatgct gatgaacttg atcccatgtc accggggcca     1500

ccttcaaaaa aagactctcg tcatcgtaag aaccgacact ctcgtcatca tcacgatcga     1560

aaggataacg aatcaatggt cactgcgggt gacagtaact caagttttgt tgatatatgt     1620

aaagaaaacg ttccgaatga tagcaagacc gcactcgata ctaaatctgt gaaccgctta     1680

aaaagtaatt tggctatgag tcccccaagt atacgatatg ctccatcaaa tttagatggg     1740

gactacgaca cgtcttccac ttcctcatct ttaccgtcct catctattag ttcagaagat     1800

acatcttcct gcagcgattc ctcttcgtac actaacgcgt atatggaggc caaccgagag     1860

caggataata aaacaccgat cctgaataaa acgaaatcgt ataccaagaa atttacatcc     1920

tcttcggtaa atatgaattc accagatggt gcccagagtt ctggattatt actacaagat     1980

gagaaggacg atgaggtcga gtgccaactg gaacattact ataaagattt cagtgattta     2040

gatccaaaga ggcactatgc tattcgtata ttcaatactg atgacacttt tacgactctc     2100

tcatgtactc cagcgactac cgtcgaagag ataatacctg cacttaaaag aaaatttaac     2160

attacagcgc aagggaattt tcaaatttcc ctgaaggtgg gaaagttgtc aaaaattttg     2220

agaccaactt cgaaacctat tttaattgaa agaaaacttt tacttttgaa tggttatcga     2280

aagtcagacc cacttcatat tatgggtata gaggatttaa gttttgtttt taagtttctt     2340

ttccatcctg tcacaccttc tcactttact cctgaacaag aacaaagaat aatgagaagc     2400

gaatttgttc acgtagattt aaggaatatg gatctgacta cacctcccat cattttttac     2460

cagcatacgt cagaaataga aagtttagac gtttctaata acgcaaatat attcctacct     2520

ctggagttca ttgaaagctc gattaaatta ttaagtttga gaatggttaa tattagagca     2580

tctaaatttc cttccaatat cactgaggcg tataaactag tatctttgga attacagaga     2640

aacttcataa gaaaagtacc gaactcaatc atgaaactga gtaatttaac gatattaaac     2700

cttcaatgta atgagcttga aagcctaccg gctggatttg ttgaactgaa aaatctgcaa     2760

ttgctagact tgtcttcaaa caagttcatg cactacccag aagttattaa ctactgcacc     2820

aatcttttac aaatagacct atcatataat aaaatccaaa gcttaccaca gtccactaag     2880

tacctagtaa agcttgcgaa gatgaacctt tctcataaca aactaaattt tataggcgac     2940

ttatcggaaa tgacaaattt gaggacgctg aacctaagat ataacagaat atcatcaatt     3000

aagacaaatg cgtctaactt gcagaacctt tttttaacag ataatagaat ttcgaacttt     3060

gaagacactt tgccgaaact aagagccctt gaaattcaag agaatccaat cacttctata     3120

tccttcaaag atttttatcc aaaaaacatg acaagtttga cgttgaacaa ggcacagtta     3180

tcgagtattc ctggagaatt actcaccaaa ctatctttcc tcgagaaact tgaacttaat     3240

cagaataatt tgactagact gccacaggag atatccaagt tgactaaatt agttttcctt     3300

tcagtggcga gaaacaaact agagtatatt ccacccgagc tatctcaact gaaaagtttg     3360

aggacattag atctacattc taacaacata agggactttg ttgacggtat ggaaaacctt     3420

gaactaacat cgctaaatat ttcatcgaat gcattcggta actctagctt agaaaattct     3480

ttttaccata acatgtcata tgggtcaaag ttatctaaaa gcctgatgtt ttttattgct     3540

gcagacaatc aatttgatga tgctatgtgg cctcttttca attgctttgt caatctgaaa     3600

gtgctaaatc tttcttacaa caatttttca gatgtatcgc acatgaaact tgagagcatt     3660

accgaattgt acctctccgg taataagctc acgacattgt cgggtgatac agttttgaaa     3720

tggagctctt taaagacttt aatgttgaat agtaaccaaa tgttatctct gcctgcagaa     3780

ttatcaaatc tctcacagct aagtgtattt gatgttggag caaatcaatt aaagtataat     3840

atatcaaact atcattacga ttggaactgg aggaataata aagaactaaa atatttgaat     3900

ttttcaggaa atcgaaggtt tgaaataaag tcatttataa gtcacgatat tgatgctgat     3960

ttgtcagatc tgacagtatt acctcagtta aaggtactag gtttaatgga cgtaacttta     4020

aatactacca aagtaccgga tgaaaatgtc aatttccgtt taaggacaac tgcatcaata     4080

ataaatggga tgcgctacgg tgttgctgat acattaggtc aaagagacta tgtgtcatct     4140

cgtgatgtta cctttgaaag attccgcgga aatgacgacg aatgcttact atgtcttcat     4200

gatagtaaaa accaaaatgc agattatggc cacaatatat caagaattgt tagagatatt     4260

tacgataaaa tactgatcag acaactggaa aggtatggag acgacacaga tgataatata     4320

aaaactgcac ttcgtttcag ttttttgcaa ctgaataagg agattaacgg aatgctaaat     4380

tctgttgata atggtgccga tgttgccaat ctttcatatg cagacttgct aagtggcgct     4440

tgctctactg tgatatatat cagagggaag aaactcttcg ctgcaaattt aggtgactgt     4500

atggctattt tatccaaaaa caatggtgac taccaaacgc taaccaaaca acatctccca     4560

acaaagcggg aagaatacga gaggatcaga atatctggcg ggtatgtcaa caatggaaaa     4620

ttagatggtg ttgtagatgt gtctagagca gtgggttttt ttgatttgct tccccacatt     4680

catgcttctc ccgacatatc tgtcgtgaca ttaacaaaag cagacgagat gcttattgta     4740

gcaacgcata agttatggga atacatggac gtggatacag tttgtgatat cgcgcgtgag     4800

aatagtactg atccactccg tgccgcagct gagttgaagg atcatgccat ggcttacggc     4860

tgtacagaga atattacaat tttgtgcctt gctctttacg agaacattca gcaacaaaat     4920

cggttcactt taaataaaaa ctctttaatg actagaagaa gtactttcga ggatactaca     4980

ttaagaagac ttcaacctga gatttctccg ccaacaggta acctagcaat ggtcttcact     5040

gatatcaaaa gctcaacctt cttatgggag ctattcccta acgcaatgag gaccgcaata     5100

aaaactcaca atgacattat gcgtcgtcaa ctacgaattt acggtggtta cgaagtaaag     5160

acagaaggag acgcctttat ggtggcattt cctacgccaa ctagtggtct tacatggtgc     5220

ttaagtgttc aattaaaact cttggatgca caatggccgg aggaaattac ctcagttcaa     5280

gacggctgcc aagttacgga tagaaatggt aacattatct atcaaggcct atcagttaga     5340

atgggtattc attggggctg cccagttcca gagcttgatt tagtgactca aagaatggac     5400

tatttggggc cgatggtcaa taaggcagca agggtccagg gcgtcgctga cggtggtcag     5460

attgcaatga gtagtgattt ttactctgaa ttcaacaaga taatgaagta tcatgaacga     5520

gtagtgaagg gcaaggaatc tctcaaggaa gtttatggtg aagaaattat cggagaggtt     5580

cttgaaagag aaattgccat gctggaaagt attggttggg cattttttga ctttggcgag     5640

cataagctaa agggactcga aaccaaagaa ctcgttacta ttgcgtatcc taagattctt     5700

gcttccagac acgaatttgc atctgaagat gagcagtcaa aattaatcaa tgaaacgatg     5760

ttgtttcatt taagagtcat ttcaaacaga ctggaatcta taatgtcagc tttaagcggc     5820

ggatttattg aactagactc tcggacggag ggaagttata ttaaatttaa ccctaaagtt     5880

gaaaatggta ttatgcaatc gatttctgag aaggatgcgt tgttattttt tgatcatgta     5940

attactagaa tcgaatccag tgtggcatta ttacatttac gacaacagag gtgttcagga     6000

ctggaaattt gcagaaacga taaaacatct gctcgaagca atattttcaa tgttgttgac     6060

gaacttttac aaatggttaa gaacgcaaag gatttatcaa cttga                     6105


<210>  8
<211>  2034
<212>  PRT
<213>  Saccharomyces cerevisiae

<400>  8

Met Ser Ser Lys Pro Asp Thr Gly Ser Glu Ile Ser Gly Pro Gln Arg 
1               5                   10                  15      


Gln Glu Glu Gln Glu Gln Gln Ile Glu Gln Ser Ser Pro Thr Glu Ala 
            20                  25                  30          


Asn Asp Arg Ser Ile His Asp Glu Val Pro Lys Val Lys Lys Arg His 
        35                  40                  45              


Glu Gln Asn Ser Gly His Lys Ser Arg Arg Asn Ser Ala Tyr Ser Tyr 
    50                  55                  60                  


Tyr Ser Pro Arg Ser Leu Ser Met Thr Lys Ser Arg Glu Ser Ile Thr 
65                  70                  75                  80  


Pro Asn Gly Met Asp Asp Val Ser Ile Ser Asn Val Glu His Pro Arg 
                85                  90                  95      


Pro Thr Glu Pro Lys Ile Lys Arg Gly Pro Tyr Leu Leu Lys Lys Thr 
            100                 105                 110         


Leu Ser Ser Leu Ser Met Thr Ser Ala Asn Ser Thr His Asp Asp Asn 
        115                 120                 125             


Lys Asp His Gly Tyr Ala Leu Asn Ser Ser Lys Thr His Asn Tyr Thr 
    130                 135                 140                 


Ser Thr His Asn His His Asp Gly His His Asp His His His Val Gln 
145                 150                 155                 160 


Phe Phe Pro Asn Arg Lys Pro Ser Leu Ala Glu Thr Leu Phe Lys Arg 
                165                 170                 175     


Phe Ser Gly Ser Asn Ser His Asp Gly Asn Lys Ser Gly Lys Glu Ser 
            180                 185                 190         


Lys Val Ala Asn Leu Ser Leu Ser Thr Val Asn Pro Ala Pro Ala Asn 
        195                 200                 205             


Arg Lys Pro Ser Lys Asp Ser Thr Leu Ser Asn His Leu Ala Asp Asn 
    210                 215                 220                 


Val Pro Ser Thr Leu Arg Arg Lys Val Ser Ser Leu Val Arg Gly Ser 
225                 230                 235                 240 


Ser Val His Asp Ile Asn Asn Gly Ile Ala Asp Lys Gln Ile Arg Pro 
                245                 250                 255     


Lys Ala Val Ala Gln Ser Glu Asn Thr Leu His Ser Ser Asp Val Pro 
            260                 265                 270         


Asn Ser Lys Arg Ser His Arg Lys Ser Phe Leu Leu Gly Ser Thr Ser 
        275                 280                 285             


Ser Ser Ser Ser Arg Arg Gly Ser Asn Val Ser Ser Met Thr Asn Ser 
    290                 295                 300                 


Asp Ser Ala Ser Met Ala Thr Ser Gly Ser His Val Leu Gln His Asn 
305                 310                 315                 320 


Val Ser Asn Val Ser Pro Thr Thr Lys Ser Lys Asp Ser Val Asn Ser 
                325                 330                 335     


Glu Ser Ala Asp His Thr Asn Asn Lys Ser Glu Lys Val Thr Pro Glu 
            340                 345                 350         


Tyr Asn Glu Asn Ile Pro Glu Asn Ser Asn Ser Asp Asn Lys Arg Glu 
        355                 360                 365             


Ala Thr Thr Pro Thr Ile Glu Thr Pro Ile Ser Cys Lys Pro Ser Leu 
    370                 375                 380                 


Phe Arg Leu Asp Thr Asn Leu Glu Asp Val Thr Asp Ile Thr Lys Thr 
385                 390                 395                 400 


Val Pro Pro Thr Ala Val Asn Ser Thr Leu Asn Ser Thr His Gly Thr 
                405                 410                 415     


Glu Thr Ala Ser Pro Lys Thr Val Ile Met Pro Glu Gly Pro Arg Lys 
            420                 425                 430         


Ser Val Ser Met Ala Asp Leu Ser Val Ala Ala Ala Ala Pro Asn Gly 
        435                 440                 445             


Glu Phe Thr Ser Thr Ser Asn Asp Arg Ser Gln Trp Val Ala Pro Gln 
    450                 455                 460                 


Ser Trp Asp Val Glu Thr Lys Arg Lys Lys Thr Lys Pro Lys Gly Arg 
465                 470                 475                 480 


Ser Lys Ser Arg Arg Ser Ser Ile Asp Ala Asp Glu Leu Asp Pro Met 
                485                 490                 495     


Ser Pro Gly Pro Pro Ser Lys Lys Asp Ser Arg His Arg Lys Asn Arg 
            500                 505                 510         


His Ser Arg His His His Asp Arg Lys Asp Asn Glu Ser Met Val Thr 
        515                 520                 525             


Ala Gly Asp Ser Asn Ser Ser Phe Val Asp Ile Cys Lys Glu Asn Val 
    530                 535                 540                 


Pro Asn Asp Ser Lys Thr Ala Leu Asp Thr Lys Ser Val Asn Arg Leu 
545                 550                 555                 560 


Lys Ser Asn Leu Ala Met Ser Pro Pro Ser Ile Arg Tyr Ala Pro Ser 
                565                 570                 575     


Asn Leu Asp Gly Asp Tyr Asp Thr Ser Ser Thr Ser Ser Ser Leu Pro 
            580                 585                 590         


Ser Ser Ser Ile Ser Ser Glu Asp Thr Ser Ser Cys Ser Asp Ser Ser 
        595                 600                 605             


Ser Tyr Thr Asn Ala Tyr Met Glu Ala Asn Arg Glu Gln Asp Asn Lys 
    610                 615                 620                 


Thr Pro Ile Leu Asn Lys Thr Lys Ser Tyr Thr Lys Lys Phe Thr Ser 
625                 630                 635                 640 


Ser Ser Val Asn Met Asn Ser Pro Asp Gly Ala Gln Ser Ser Gly Leu 
                645                 650                 655     


Leu Leu Gln Asp Glu Lys Asp Asp Glu Val Glu Cys Gln Leu Glu His 
            660                 665                 670         


Tyr Tyr Lys Asp Phe Ser Asp Leu Asp Pro Lys Arg His Tyr Ala Ile 
        675                 680                 685             


Arg Ile Phe Asn Thr Asp Asp Thr Phe Thr Thr Leu Ser Cys Thr Pro 
    690                 695                 700                 


Ala Thr Thr Val Glu Glu Ile Ile Pro Ala Leu Lys Arg Lys Phe Asn 
705                 710                 715                 720 


Ile Thr Ala Gln Gly Asn Phe Gln Ile Ser Leu Lys Val Gly Lys Leu 
                725                 730                 735     


Ser Lys Ile Leu Arg Pro Thr Ser Lys Pro Ile Leu Ile Glu Arg Lys 
            740                 745                 750         


Leu Leu Leu Leu Asn Gly Tyr Arg Lys Ser Asp Pro Leu His Ile Met 
        755                 760                 765             


Gly Ile Glu Asp Leu Ser Phe Val Phe Lys Phe Leu Phe His Pro Val 
    770                 775                 780                 


Thr Pro Ser His Phe Thr Pro Glu Gln Glu Gln Arg Ile Met Arg Ser 
785                 790                 795                 800 


Glu Phe Val His Val Asp Leu Arg Asn Met Asp Leu Thr Thr Pro Pro 
                805                 810                 815     


Ile Ile Phe Tyr Gln His Thr Ser Glu Ile Glu Ser Leu Asp Val Ser 
            820                 825                 830         


Asn Asn Ala Asn Ile Phe Leu Pro Leu Glu Phe Ile Glu Ser Ser Ile 
        835                 840                 845             


Lys Leu Leu Ser Leu Arg Met Val Asn Ile Arg Ala Ser Lys Phe Pro 
    850                 855                 860                 


Ser Asn Ile Thr Glu Ala Tyr Lys Leu Val Ser Leu Glu Leu Gln Arg 
865                 870                 875                 880 


Asn Phe Ile Arg Lys Val Pro Asn Ser Ile Met Lys Leu Ser Asn Leu 
                885                 890                 895     


Thr Ile Leu Asn Leu Gln Cys Asn Glu Leu Glu Ser Leu Pro Ala Gly 
            900                 905                 910         


Phe Val Glu Leu Lys Asn Leu Gln Leu Leu Asp Leu Ser Ser Asn Lys 
        915                 920                 925             


Phe Met His Tyr Pro Glu Val Ile Asn Tyr Cys Thr Asn Leu Leu Gln 
    930                 935                 940                 


Ile Asp Leu Ser Tyr Asn Lys Ile Gln Ser Leu Pro Gln Ser Thr Lys 
945                 950                 955                 960 


Tyr Leu Val Lys Leu Ala Lys Met Asn Leu Ser His Asn Lys Leu Asn 
                965                 970                 975     


Phe Ile Gly Asp Leu Ser Glu Met Thr Asn Leu Arg Thr Leu Asn Leu 
            980                 985                 990         


Arg Tyr Asn Arg Ile Ser Ser Ile  Lys Thr Asn Ala Ser  Asn Leu Gln 
        995                 1000                 1005             


Asn Leu  Phe Leu Thr Asp Asn  Arg Ile Ser Asn Phe  Glu Asp Thr 
    1010                 1015                 1020             


Leu Pro  Lys Leu Arg Ala Leu  Glu Ile Gln Glu Asn  Pro Ile Thr 
    1025                 1030                 1035             


Ser Ile  Ser Phe Lys Asp Phe  Tyr Pro Lys Asn Met  Thr Ser Leu 
    1040                 1045                 1050             


Thr Leu  Asn Lys Ala Gln Leu  Ser Ser Ile Pro Gly  Glu Leu Leu 
    1055                 1060                 1065             


Thr Lys  Leu Ser Phe Leu Glu  Lys Leu Glu Leu Asn  Gln Asn Asn 
    1070                 1075                 1080             


Leu Thr  Arg Leu Pro Gln Glu  Ile Ser Lys Leu Thr  Lys Leu Val 
    1085                 1090                 1095             


Phe Leu  Ser Val Ala Arg Asn  Lys Leu Glu Tyr Ile  Pro Pro Glu 
    1100                 1105                 1110             


Leu Ser  Gln Leu Lys Ser Leu  Arg Thr Leu Asp Leu  His Ser Asn 
    1115                 1120                 1125             


Asn Ile  Arg Asp Phe Val Asp  Gly Met Glu Asn Leu  Glu Leu Thr 
    1130                 1135                 1140             


Ser Leu  Asn Ile Ser Ser Asn  Ala Phe Gly Asn Ser  Ser Leu Glu 
    1145                 1150                 1155             


Asn Ser  Phe Tyr His Asn Met  Ser Tyr Gly Ser Lys  Leu Ser Lys 
    1160                 1165                 1170             


Ser Leu  Met Phe Phe Ile Ala  Ala Asp Asn Gln Phe  Asp Asp Ala 
    1175                 1180                 1185             


Met Trp  Pro Leu Phe Asn Cys  Phe Val Asn Leu Lys  Val Leu Asn 
    1190                 1195                 1200             


Leu Ser  Tyr Asn Asn Phe Ser  Asp Val Ser His Met  Lys Leu Glu 
    1205                 1210                 1215             


Ser Ile  Thr Glu Leu Tyr Leu  Ser Gly Asn Lys Leu  Thr Thr Leu 
    1220                 1225                 1230             


Ser Gly  Asp Thr Val Leu Lys  Trp Ser Ser Leu Lys  Thr Leu Met 
    1235                 1240                 1245             


Leu Asn  Ser Asn Gln Met Leu  Ser Leu Pro Ala Glu  Leu Ser Asn 
    1250                 1255                 1260             


Leu Ser  Gln Leu Ser Val Phe  Asp Val Gly Ala Asn  Gln Leu Lys 
    1265                 1270                 1275             


Tyr Asn  Ile Ser Asn Tyr His  Tyr Asp Trp Asn Trp  Arg Asn Asn 
    1280                 1285                 1290             


Lys Glu  Leu Lys Tyr Leu Asn  Phe Ser Gly Asn Arg  Arg Phe Glu 
    1295                 1300                 1305             


Ile Lys  Ser Phe Ile Ser His  Asp Ile Asp Ala Asp  Leu Ser Asp 
    1310                 1315                 1320             


Leu Thr  Val Leu Pro Gln Leu  Lys Val Leu Gly Leu  Met Asp Val 
    1325                 1330                 1335             


Thr Leu  Asn Thr Thr Lys Val  Pro Asp Glu Asn Val  Asn Phe Arg 
    1340                 1345                 1350             


Leu Arg  Thr Thr Ala Ser Ile  Ile Asn Gly Met Arg  Tyr Gly Val 
    1355                 1360                 1365             


Ala Asp  Thr Leu Gly Gln Arg  Asp Tyr Val Ser Ser  Arg Asp Val 
    1370                 1375                 1380             


Thr Phe  Glu Arg Phe Arg Gly  Asn Asp Asp Glu Cys  Leu Leu Cys 
    1385                 1390                 1395             


Leu His  Asp Ser Lys Asn Gln  Asn Ala Asp Tyr Gly  His Asn Ile 
    1400                 1405                 1410             


Ser Arg  Ile Val Arg Asp Ile  Tyr Asp Lys Ile Leu  Ile Arg Gln 
    1415                 1420                 1425             


Leu Glu  Arg Tyr Gly Asp Asp  Thr Asp Asp Asn Ile  Lys Thr Ala 
    1430                 1435                 1440             


Leu Arg  Phe Ser Phe Leu Gln  Leu Asn Lys Glu Ile  Asn Gly Met 
    1445                 1450                 1455             


Leu Asn  Ser Val Asp Asn Gly  Ala Asp Val Ala Asn  Leu Ser Tyr 
    1460                 1465                 1470             


Ala Asp  Leu Leu Ser Gly Ala  Cys Ser Thr Val Ile  Tyr Ile Arg 
    1475                 1480                 1485             


Gly Lys  Lys Leu Phe Ala Ala  Asn Leu Gly Asp Cys  Met Ala Ile 
    1490                 1495                 1500             


Leu Ser  Lys Asn Asn Gly Asp  Tyr Gln Thr Leu Thr  Lys Gln His 
    1505                 1510                 1515             


Leu Pro  Thr Lys Arg Glu Glu  Tyr Glu Arg Ile Arg  Ile Ser Gly 
    1520                 1525                 1530             


Gly Tyr  Val Asn Asn Gly Lys  Leu Asp Gly Val Val  Asp Val Ser 
    1535                 1540                 1545             


Arg Ala  Val Gly Phe Phe Asp  Leu Leu Pro His Ile  His Ala Ser 
    1550                 1555                 1560             


Pro Asp  Ile Ser Val Val Thr  Leu Thr Lys Ala Asp  Glu Met Leu 
    1565                 1570                 1575             


Ile Val  Ala Thr His Lys Leu  Trp Glu Tyr Met Asp  Val Asp Thr 
    1580                 1585                 1590             


Val Cys  Asp Ile Ala Arg Glu  Asn Ser Thr Asp Pro  Leu Arg Ala 
    1595                 1600                 1605             


Ala Ala  Glu Leu Lys Asp His  Ala Met Ala Tyr Gly  Cys Thr Glu 
    1610                 1615                 1620             


Asn Ile  Thr Ile Leu Cys Leu  Ala Leu Tyr Glu Asn  Ile Gln Gln 
    1625                 1630                 1635             


Gln Asn  Arg Phe Thr Leu Asn  Lys Asn Ser Leu Met  Thr Arg Arg 
    1640                 1645                 1650             


Ser Thr  Phe Glu Asp Thr Thr  Leu Arg Arg Leu Gln  Pro Glu Ile 
    1655                 1660                 1665             


Ser Pro  Pro Thr Gly Asn Leu  Ala Met Val Phe Thr  Asp Ile Lys 
    1670                 1675                 1680             


Ser Ser  Thr Phe Leu Trp Glu  Leu Phe Pro Asn Ala  Met Arg Thr 
    1685                 1690                 1695             


Ala Ile  Lys Thr His Asn Asp  Ile Met Arg Arg Gln  Leu Arg Ile 
    1700                 1705                 1710             


Tyr Gly  Gly Tyr Glu Val Lys  Thr Glu Gly Asp Ala  Phe Met Val 
    1715                 1720                 1725             


Ala Phe  Pro Thr Pro Thr Ser  Gly Leu Thr Trp Cys  Leu Ser Val 
    1730                 1735                 1740             


Gln Leu  Lys Leu Leu Asp Ala  Gln Trp Pro Glu Glu  Ile Thr Ser 
    1745                 1750                 1755             


Val Gln  Asp Gly Cys Gln Val  Thr Asp Arg Asn Gly  Asn Ile Ile 
    1760                 1765                 1770             


Tyr Gln  Gly Leu Ser Val Arg  Met Gly Ile His Trp  Gly Cys Pro 
    1775                 1780                 1785             


Val Pro  Glu Leu Asp Leu Val  Thr Gln Arg Met Asp  Tyr Leu Gly 
    1790                 1795                 1800             


Pro Met  Val Asn Lys Ala Ala  Arg Val Gln Gly Val  Ala Asp Gly 
    1805                 1810                 1815             


Gly Gln  Ile Ala Met Ser Ser  Asp Phe Tyr Ser Glu  Phe Asn Lys 
    1820                 1825                 1830             


Ile Met  Lys Tyr His Glu Arg  Val Val Lys Gly Lys  Glu Ser Leu 
    1835                 1840                 1845             


Lys Glu  Val Tyr Gly Glu Glu  Ile Ile Gly Glu Val  Leu Glu Arg 
    1850                 1855                 1860             


Glu Ile  Ala Met Leu Glu Ser  Ile Gly Trp Ala Phe  Phe Asp Phe 
    1865                 1870                 1875             


Gly Glu  His Lys Leu Lys Gly  Leu Glu Thr Lys Glu  Leu Val Thr 
    1880                 1885                 1890             


Ile Ala  Tyr Pro Lys Ile Leu  Ala Ser Arg His Glu  Phe Ala Ser 
    1895                 1900                 1905             


Glu Asp  Glu Gln Ser Lys Leu  Ile Asn Glu Thr Met  Leu Phe His 
    1910                 1915                 1920             


Leu Arg  Val Ile Ser Asn Arg  Leu Glu Ser Ile Met  Ser Ala Leu 
    1925                 1930                 1935             


Ser Gly  Gly Phe Ile Glu Leu  Asp Ser Arg Thr Glu  Gly Ser Tyr 
    1940                 1945                 1950             


Ile Lys  Phe Asn Pro Lys Val  Glu Asn Gly Ile Met  Gln Ser Ile 
    1955                 1960                 1965             


Ser Glu  Lys Asp Ala Leu Leu  Phe Phe Asp His Val  Ile Thr Arg 
    1970                 1975                 1980             


Ile Glu  Ser Ser Val Ala Leu  Leu His Leu Arg Gln  Gln Arg Cys 
    1985                 1990                 1995             


Ser Gly  Leu Glu Ile Cys Arg  Asn Asp Lys Thr Ser  Ala Arg Ser 
    2000                 2005                 2010             


Asn Ile  Phe Asn Val Val Asp  Glu Leu Leu Gln Met  Val Lys Asn 
    2015                 2020                 2025             


Ala Lys  Asp Leu Ser Thr 
    2030                 


