                         SEQUENCE LISTING

<110>  LAVA Therapeutics
 
<120>  Novel bispecific antibodies for use in the treatment of 
       hematological malignancies

<130>  P6088362PCT

<160>  165   

<170>  PatentIn version 3.5

<210>  1
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody sequence

<400>  1

Ser Tyr Thr Met Gly 
1               5   


<210>  2
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody sequence

<400>  2

Ala Ile Arg Trp Ser Gly Glu Ser Pro Tyr Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  3
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody sequence

<400>  3

Arg Leu Val Pro Pro Gly Ile Pro Ile Glu Arg Ser Leu Glu Asn Met 
1               5                   10                  15      


Asn Tyr 
        


<210>  4
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody sequence

<400>  4

Ser Tyr Thr Met Gly 
1               5   


<210>  5
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody sequence

<400>  5

Val Ile Arg Trp Ser Gly Glu Ser Pro Tyr Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  6
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody sequence

<400>  6

Arg Leu Val Pro Pro Gly Ile Pro Ile Glu Arg Thr Leu Glu Ser Met 
1               5                   10                  15      


Asn Tyr 
        


<210>  7
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody sequence

<400>  7

Ser Tyr Thr Met Gly 
1               5   


<210>  8
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody sequence

<400>  8

Ala Ile Arg Trp Ser Gly Glu Ser Pro Ile Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  9
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody sequence

<400>  9

Arg Leu Val Pro Pro Gly Ile Pro Ile Glu Arg Thr Leu Glu Ser Met 
1               5                   10                  15      


Arg Tyr 
        


<210>  10
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody sequence

<400>  10

Ser Tyr Thr Met Gly 
1               5   


<210>  11
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody sequence

<400>  11

Ala Ile Arg Trp Ser Gly Glu Ser Pro Tyr Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  12
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody sequence

<400>  12

Arg Leu Val Pro Pro Gly Ile Pro Ile Glu Arg Thr Leu Glu Ser Met 
1               5                   10                  15      


Lys Asp 
        


<210>  13
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody sequence

<400>  13

Ser Tyr Thr Met Gly 
1               5   


<210>  14
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody sequence

<400>  14

Gly Ile Arg Trp Ser Asp Glu Ser Pro Ile Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  15
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody sequence

<400>  15

Arg Leu Val Pro Pro Gly Ile Pro Ile Pro Arg Thr Ser Glu Ser Met 
1               5                   10                  15      


Arg Tyr 
        


<210>  16
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody sequence

<400>  16

Ser Tyr Thr Met Ala 
1               5   


<210>  17
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody sequence

<400>  17

Ala Ile Arg Trp Ser Gly Glu Ser Pro Ile Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  18
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody sequence

<400>  18

Arg Leu Val Pro Pro Gly Ile Pro Ile Glu Arg Thr Leu Glu Ser Met 
1               5                   10                  15      


Arg Tyr 
        


<210>  19
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody sequence

<400>  19

Ser Tyr Thr Met Gly 
1               5   


<210>  20
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody sequence

<400>  20

Gly Ile Arg Trp Asp Asp Glu Asn Pro Tyr Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  21
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody sequence

<400>  21

Arg Leu Val Pro Pro Gly Ile Pro Phe Glu Arg Thr Leu Glu Asn Met 
1               5                   10                  15      


Arg Tyr 
        


<210>  22
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody sequence

<400>  22

Ser Tyr Thr Met Gly 
1               5   


<210>  23
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody sequence

<400>  23

Ala Ile Arg Trp Asp Gly Glu Ser Pro Ile Tyr Ala Glu Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  24
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody sequence

<400>  24

Arg Leu Val Pro Pro Gly Ile Pro Ile Glu Arg Thr Leu Glu Ser Met 
1               5                   10                  15      


Arg Tyr 
        


<210>  25
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody sequence

<400>  25

Ser Tyr Thr Met Gly 
1               5   


<210>  26
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody sequence

<400>  26

Val Ile Arg Trp Ser Gly Glu Ser Pro Tyr Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  27
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody sequence

<400>  27

Arg Leu Val Pro Pro Gly Ile Pro Ile Glu Arg Thr Leu Glu Ser Met 
1               5                   10                  15      


Asn Tyr 
        


<210>  28
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody sequence

<400>  28

Ser Tyr Thr Met Gly 
1               5   


<210>  29
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody sequence

<400>  29

Ala Ile Arg Trp Ser Asp Glu Ser Pro Ile Tyr Ala Gly Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  30
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody sequence

<400>  30

Arg Leu Val Pro Pro Gly Ile Pro Ile Glu Arg Thr Leu Glu Ser Met 
1               5                   10                  15      


Arg Tyr 
        


<210>  31
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody sequence

<400>  31

Ser Tyr Thr Met Gly 
1               5   


<210>  32
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody sequence

<400>  32

Ala Ile Arg Trp Ser Asp Glu Ser Pro Tyr Tyr Ser Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  33
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody sequence

<400>  33

Arg Leu Val Pro Pro Gly Ile Pro Ile Glu Arg Thr Leu Glu Asn Met 
1               5                   10                  15      


Arg Tyr Ser 
            


<210>  34
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody sequence

<400>  34

Asp Asn Val Met Gly 
1               5   


<210>  35
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody sequence

<400>  35

Thr Ile Arg Thr Gly Gly Ser Thr Asn Tyr Ala Asp Ser Val Lys Gly 
1               5                   10                  15      


<210>  36
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody sequence

<400>  36

Thr Ile Pro Val Pro Ser Thr Pro Tyr Asp Tyr 
1               5                   10      


<210>  37
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody sequence

<400>  37

Ser Tyr Thr Met Gly 
1               5   


<210>  38
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody sequence

<400>  38

Ala Ile Arg Trp Ser Gly Glu Ser Pro Tyr Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  39
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody sequence

<400>  39

Arg Leu Val Pro Pro Gly Ile Pro Ile Glu Arg Thr Leu Glu Asn Met 
1               5                   10                  15      


Asn Tyr 
        


<210>  40
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody sequence

<400>  40

Ser Tyr Thr Met Gly 
1               5   


<210>  41
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody sequence

<400>  41

Ala Ile Arg Trp Ser Gly Glu Ser Pro Tyr Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  42
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody sequence

<400>  42

Arg Leu Val Pro Pro Gly Ile Pro Ile Glu Arg Thr Leu Glu Ser Met 
1               5                   10                  15      


Asn Tyr 
        


<210>  43
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody sequence

<400>  43

Ser Tyr Thr Met Gly 
1               5   


<210>  44
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody sequence

<400>  44

Ala Ile Arg Trp Ser Gly Glu Ser Pro Ile Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  45
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody sequence

<400>  45

Arg Leu Val Pro Pro Gly Ile Pro Ile Glu Arg Thr Leu Glu Ser Met 
1               5                   10                  15      


Lys Asp 
        


<210>  46
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody sequence

<400>  46

Ser Tyr Thr Met Thr 
1               5   


<210>  47
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody sequence

<400>  47

Gly Ile Arg Trp Ser Gly Glu Ser Pro Tyr Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  48
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody sequence

<400>  48

Arg Leu Val Pro Pro Gly Ile Pro Ile Glu Arg Thr Leu Glu Ser Met 
1               5                   10                  15      


Arg Tyr 
        


<210>  49
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody sequence

<400>  49

Ser Tyr Thr Met Gly 
1               5   


<210>  50
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody sequence

<400>  50

Ala Ile Arg Trp Ser Gly Glu Ser Pro Tyr Tyr Gly Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  51
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody sequence

<400>  51

Arg Leu Val Pro Pro Gly Ile Pro Ile Gly Arg Thr Leu Glu Ser Met 
1               5                   10                  15      


Asn Asn 
        


<210>  52
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody sequence

<400>  52

Ser Tyr Thr Met Gly 
1               5   


<210>  53
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody sequence

<400>  53

Ala Ile Arg Trp Ser Gly Glu Ser Pro Tyr Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  54
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody sequence

<400>  54

Arg Leu Val Pro Pro Gly Ile Pro Ile Glu Arg Ala Leu Glu Asn Met 
1               5                   10                  15      


Asn Tyr 
        


<210>  55
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody sequence

<400>  55

Ser Tyr Thr Met Gly 
1               5   


<210>  56
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody sequence

<400>  56

Ala Ile Arg Trp Ser Asp Glu Ser Pro Ile Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  57
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody sequence

<400>  57

Arg Leu Val Pro Pro Gly Ile Pro Ile Glu Arg Thr Leu Glu Ser Met 
1               5                   10                  15      


Arg Tyr 
        


<210>  58
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody sequence

<400>  58

Ser Tyr Thr Met Gly 
1               5   


<210>  59
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody sequence

<400>  59

Ala Ile Arg Trp Ser Gly Glu Ser Pro Tyr Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  60
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody sequence

<400>  60

Arg Leu Val Pro Pro Gly Ile Pro Ile Glu Arg Ser Leu Glu Asn Met 
1               5                   10                  15      


Asn Tyr 
        


<210>  61
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody sequence

<400>  61

Asn Ala Met Gly 
1               


<210>  62
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody sequence

<400>  62

Val Ile Ser Ser Ser Gly Ser Thr Asn Tyr Ala Asp Ser Val Lys Gly 
1               5                   10                  15      


<210>  63
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody sequence

<400>  63

His Val Ala Gly Phe Asp Glu Tyr Asn Tyr 
1               5                   10  


<210>  64
<211>  126
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody sequence

<400>  64

Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly Ser 
1               5                   10                  15      


Leu Arg Leu Ser Cys Ala Ala Ser Gly Ser Ser Phe Ser Ser Tyr Thr 
            20                  25                  30          


Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Ile Val Ala 
        35                  40                  45              


Ala Ile Arg Trp Ser Gly Glu Ser Pro Tyr Tyr Ala Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Phe Cys Ala 
                85                  90                  95      


Ala Arg Leu Val Pro Pro Gly Ile Pro Ile Glu Arg Ser Leu Glu Asn 
            100                 105                 110         


Met Asn Tyr Trp Gly Lys Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125     


<210>  65
<211>  126
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody sequence

<400>  65

Val Gln Leu Val Glu Ser Gly Gly Gly Ser Val Gln Ala Gly Gly Ser 
1               5                   10                  15      


Leu Arg Leu Ser Cys Ala Ala Ser Gly Arg Ser Phe Ser Ser Tyr Thr 
            20                  25                  30          


Met Gly Trp Cys Arg Gln Ala Pro Gly Lys Glu Arg Glu Cys Val Ala 
        35                  40                  45              


Val Ile Arg Trp Ser Gly Glu Ser Pro Tyr Tyr Ala Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Ala Arg Leu Val Pro Pro Gly Ile Pro Ile Glu Arg Thr Leu Glu Ser 
            100                 105                 110         


Met Asn Tyr Trp Gly Lys Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125     


<210>  66
<211>  127
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody sequence

<400>  66

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Ser Ser Phe Ser Ser Tyr 
            20                  25                  30          


Thr Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Ile Val 
        35                  40                  45              


Ala Ala Ile Arg Trp Ser Gly Glu Ser Pro Ile Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Arg Leu Val Pro Pro Gly Ile Pro Ile Glu Arg Thr Leu Glu 
            100                 105                 110         


Ser Met Arg Tyr Trp Gly Lys Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125         


<210>  67
<211>  130
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody sequence

<400>  67

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Gly Leu Ser Cys Ala Ala Ser Gly Arg Ser Phe Ser Ser Tyr 
            20                  25                  30          


Thr Met Gly Val Ile Arg Trp Ser Gly Glu Ser Pro Tyr Tyr Ala Asp 
        35                  40                  45              


Ser Val Lys Gly Ala Ile Arg Trp Ser Gly Glu Ser Pro Tyr Tyr Ala 
    50                  55                  60                  


Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn 
65                  70                  75                  80  


Thr Leu Tyr Leu Gln Met Asn Asn Leu Lys Pro Glu Asp Thr Ala Val 
                85                  90                  95      


Tyr Tyr Cys Ala Ala Arg Leu Val Pro Pro Gly Ile Pro Ile Glu Arg 
            100                 105                 110         


Thr Leu Glu Ser Met Lys Asp Trp Gly Lys Gly Thr Leu Val Thr Val 
        115                 120                 125             


Ser Ser 
    130 


<210>  68
<211>  129
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody sequence

<400>  68

Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly Ser 
1               5                   10                  15      


Leu Arg Leu Ser Cys Ala Ala Ser Gly Ser Ser Phe Ser Ser Tyr Thr 
            20                  25                  30          


Met Gly Ala Ile Arg Trp Ser Asp Glu Ser Pro Ile Tyr Ala Gly Ser 
        35                  40                  45              


Val Lys Gly Gly Ile Arg Trp Ser Asp Glu Ser Pro Ile Tyr Ala Asp 
    50                  55                  60                  


Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr 
65                  70                  75                  80  


Leu Tyr Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Ala Ala Arg Leu Val Pro Pro Gly Ile Pro Ile Pro Arg Thr 
            100                 105                 110         


Ser Glu Ser Met Arg Tyr Trp Gly Lys Gly Thr Leu Val Thr Val Ser 
        115                 120                 125             


Ser 
    


<210>  69
<211>  130
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody sequence

<400>  69

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Asp 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Ser Ser Phe Ser Ser Tyr 
            20                  25                  30          


Thr Met Ala Ala Ile Arg Trp Ser Asp Glu Ser Pro Tyr Tyr Ser Asp 
        35                  40                  45              


Ser Val Lys Gly Ala Ile Arg Trp Ser Gly Glu Ser Pro Ile Tyr Ala 
    50                  55                  60                  


Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn 
65                  70                  75                  80  


Thr Leu Tyr Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val 
                85                  90                  95      


Tyr Asn Cys Ala Ala Arg Leu Val Pro Pro Gly Ile Pro Ile Glu Arg 
            100                 105                 110         


Thr Leu Glu Ser Met Arg Tyr Trp Gly Lys Gly Thr Leu Val Thr Val 
        115                 120                 125             


Ser Ser 
    130 


<210>  70
<211>  129
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody sequence

<400>  70

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Val Ser Ser Phe Ser Ser Tyr 
            20                  25                  30          


Thr Met Gly Thr Ile Arg Thr Gly Gly Ser Thr Asn Tyr Ala Asp Ser 
        35                  40                  45              


Val Lys Gly Gly Ile Arg Trp Asp Asp Glu Asn Pro Tyr Tyr Ala Asp 
    50                  55                  60                  


Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr 
65                  70                  75                  80  


Leu Tyr Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Asn Tyr 
                85                  90                  95      


Tyr Cys Ala Ala Arg Leu Val Pro Pro Gly Ile Pro Phe Glu Arg Thr 
            100                 105                 110         


Leu Glu Asn Met Arg Tyr Trp Gly Lys Gly Thr Leu Val Thr Val Ser 
        115                 120                 125             


Ser 
    


<210>  71
<211>  130
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody sequence

<400>  71

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Ser Ser Phe Ser Ser Tyr 
            20                  25                  30          


Thr Met Gly Ala Ile Arg Trp Ser Gly Glu Ser Pro Tyr Tyr Ala Asp 
        35                  40                  45              


Ser Val Lys Gly Ala Ile Arg Trp Asp Gly Glu Ser Pro Ile Tyr Ala 
    50                  55                  60                  


Glu Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn 
65                  70                  75                  80  


Thr Leu Tyr Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val 
                85                  90                  95      


Tyr Tyr Cys Ala Ala Arg Leu Val Pro Pro Gly Ile Pro Ile Glu Arg 
            100                 105                 110         


Thr Leu Glu Ser Met Arg Tyr Trp Gly Lys Gly Thr Leu Val Thr Val 
        115                 120                 125             


Ser Ser 
    130 


<210>  72
<211>  130
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody sequence

<400>  72

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Ser Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Arg Ser Phe Ser Ser Tyr 
            20                  25                  30          


Thr Met Gly Ala Ile Arg Trp Ser Gly Glu Ser Pro Tyr Tyr Ala Asp 
        35                  40                  45              


Ser Val Lys Gly Val Ile Arg Trp Ser Gly Glu Ser Pro Tyr Tyr Ala 
    50                  55                  60                  


Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn 
65                  70                  75                  80  


Thr Val Tyr Leu Gln Met Ala Ser Leu Lys Pro Asp Asp Thr Ala Val 
                85                  90                  95      


Tyr Tyr Cys Ala Ala Arg Leu Val Pro Pro Gly Ile Pro Ile Glu Arg 
            100                 105                 110         


Thr Leu Glu Ser Met Asn Tyr Trp Gly Lys Gly Thr Leu Val Thr Val 
        115                 120                 125             


Ser Ser 
    130 


<210>  73
<211>  130
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody sequence

<400>  73

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Ser Ser Phe Ser Ser Tyr 
            20                  25                  30          


Thr Met Gly Ala Ile Arg Trp Ser Gly Glu Ser Pro Tyr Tyr Ala Asp 
        35                  40                  45              


Ser Val Lys Gly Ala Ile Arg Trp Ser Asp Glu Ser Pro Ile Tyr Ala 
    50                  55                  60                  


Gly Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn 
65                  70                  75                  80  


Thr Leu Tyr Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val 
                85                  90                  95      


Tyr Tyr Cys Ala Ala Arg Leu Val Pro Pro Gly Ile Pro Ile Glu Arg 
            100                 105                 110         


Thr Leu Glu Ser Met Arg Tyr Trp Gly Lys Gly Thr Leu Val Thr Val 
        115                 120                 125             


Ser Ser 
    130 


<210>  74
<211>  129
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody sequence

<400>  74

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Ser Ser Phe Ser Ser Tyr 
            20                  25                  30          


Thr Met Gly Ser Ile Asn Asn Gly Gly Ser Thr Lys Tyr Ala Asp Ser 
        35                  40                  45              


Val Lys Gly Ala Ile Arg Trp Ser Asp Glu Ser Pro Tyr Tyr Ser Asp 
    50                  55                  60                  


Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr 
65                  70                  75                  80  


Leu Tyr Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Ser Ala Arg Leu Val Pro Pro Gly Ile Pro Ile Glu Arg Thr 
            100                 105                 110         


Leu Glu Asn Met Arg Tyr Ser Gly Lys Gly Thr Leu Val Thr Val Ser 
        115                 120                 125             


Ser 
    


<210>  75
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody sequence

<400>  75

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Ser Met Phe Ser Asp Asn 
            20                  25                  30          


Val Met Gly Ala Ile Arg Trp Ser Gly Glu Ser Pro Tyr Tyr Val Asp 
        35                  40                  45              


Ser Val Lys Gly Thr Ile Arg Thr Gly Gly Ser Thr Asn Tyr Ala Asp 
    50                  55                  60                  


Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr 
65                  70                  75                  80  


Val Tyr Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Arg His Thr Ile Pro Val Pro Ser Thr Pro Tyr Asp Tyr Trp 
            100                 105                 110         


Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
        115                 120         


<210>  76
<211>  130
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody sequence

<400>  76

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Gly Leu Ser Cys Ala Ala Ser Gly Arg Ser Phe Ser Ser Tyr 
            20                  25                  30          


Thr Met Gly Ala Ile Arg Trp Ser Gly Glu Ser Pro Ile Tyr Ala Asp 
        35                  40                  45              


Ser Val Lys Gly Ala Ile Arg Trp Ser Gly Glu Ser Pro Tyr Tyr Ala 
    50                  55                  60                  


Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn 
65                  70                  75                  80  


Thr Leu Tyr Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val 
                85                  90                  95      


Tyr Tyr Cys Ala Ala Arg Leu Val Pro Pro Gly Ile Pro Ile Glu Arg 
            100                 105                 110         


Thr Leu Glu Asn Met Asn Tyr Trp Gly Lys Gly Thr Leu Val Thr Val 
        115                 120                 125             


Ser Ser 
    130 


<210>  77
<211>  129
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody sequence

<400>  77

Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly Ser 
1               5                   10                  15      


Leu Arg Leu Ser Cys Ala Ala Ser Gly Ser Ser Phe Ser Ser Tyr Thr 
            20                  25                  30          


Met Gly Gly Ile Arg Trp Ser Gly Glu Ser Pro Tyr Tyr Ala Asp Ser 
        35                  40                  45              


Val Lys Gly Ala Ile Arg Trp Ser Gly Glu Ser Pro Tyr Tyr Ala Asp 
    50                  55                  60                  


Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr 
65                  70                  75                  80  


Leu Tyr Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Ala Ala Arg Leu Val Pro Pro Gly Ile Pro Ile Glu Arg Thr 
            100                 105                 110         


Leu Glu Ser Met Asn Tyr Trp Gly Lys Gly Thr Leu Val Thr Val Ser 
        115                 120                 125             


Ser 
    


<210>  78
<211>  130
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody sequence

<400>  78

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Ser Ser Phe Ser Ser Tyr 
            20                  25                  30          


Thr Met Gly Ala Ile Arg Trp Ser Gly Glu Ser Pro Tyr Tyr Ala Asp 
        35                  40                  45              


Ser Val Lys Gly Ala Ile Arg Trp Ser Gly Glu Ser Pro Ile Tyr Ala 
    50                  55                  60                  


Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn 
65                  70                  75                  80  


Thr Leu Tyr Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val 
                85                  90                  95      


Tyr Tyr Cys Ala Ala Arg Leu Val Pro Pro Gly Ile Pro Ile Glu Arg 
            100                 105                 110         


Thr Leu Glu Ser Met Lys Asp Trp Gly Lys Gly Thr Leu Val Thr Val 
        115                 120                 125             


Ser Ser 
    130 


<210>  79
<211>  129
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody sequence

<400>  79

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Ser Ser Phe Ser Ser Tyr 
            20                  25                  30          


Thr Met Thr Val Ile Ser Ser Ser Gly Ser Thr Asn Tyr Ala Asp Ser 
        35                  40                  45              


Val Lys Gly Gly Ile Arg Trp Ser Gly Glu Ser Pro Tyr Tyr Ala Asp 
    50                  55                  60                  


Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr 
65                  70                  75                  80  


Leu Tyr Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Ala Ala Arg Leu Val Pro Pro Gly Ile Pro Ile Glu Arg Thr 
            100                 105                 110         


Leu Glu Ser Met Arg Tyr Trp Gly Lys Gly Thr Leu Val Thr Val Ser 
        115                 120                 125             


Ser 
    


<210>  80
<211>  129
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody sequence

<400>  80

Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly Ser 
1               5                   10                  15      


Leu Arg Leu Ser Cys Ala Ala Ser Gly Ser Ser Phe Ser Ser Tyr Thr 
            20                  25                  30          


Met Gly Val Ile Arg Trp Ser Gly Glu Ser Pro Tyr Tyr Ala Asp Ser 
        35                  40                  45              


Val Lys Gly Ala Ile Arg Trp Ser Gly Glu Ser Pro Tyr Tyr Gly Asp 
    50                  55                  60                  


Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr 
65                  70                  75                  80  


Leu Tyr Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Ala Ala Arg Leu Val Pro Pro Gly Ile Pro Ile Gly Arg Thr 
            100                 105                 110         


Leu Glu Ser Met Asn Asn Trp Gly Lys Gly Thr Leu Val Thr Val Ser 
        115                 120                 125             


Ser 
    


<210>  81
<211>  130
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody sequence

<400>  81

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Ser Ser Phe Ser Ser Tyr 
            20                  25                  30          


Thr Met Gly Ala Ile Arg Trp Ser Asp Glu Ser Pro Ile Tyr Ala Gly 
        35                  40                  45              


Ser Val Lys Gly Ala Ile Arg Trp Ser Gly Glu Ser Pro Tyr Tyr Ala 
    50                  55                  60                  


Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn 
65                  70                  75                  80  


Thr Leu Tyr Leu Gln Met His Ser Leu Lys Pro Glu Asp Thr Ala Val 
                85                  90                  95      


Tyr Tyr Cys Ala Ala Arg Leu Val Pro Pro Gly Ile Pro Ile Glu Arg 
            100                 105                 110         


Ala Leu Glu Asn Met Asn Tyr Trp Gly Lys Gly Thr Leu Val Thr Val 
        115                 120                 125             


Ser Ser 
    130 


<210>  82
<211>  130
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody sequence

<400>  82

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Ser Ser Phe Ser Ser Tyr 
            20                  25                  30          


Thr Met Gly Ala Ile Arg Trp Ser Asp Glu Ser Pro Tyr Tyr Ser Asp 
        35                  40                  45              


Ser Val Lys Gly Ala Ile Arg Trp Ser Asp Glu Ser Pro Ile Tyr Ala 
    50                  55                  60                  


Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn 
65                  70                  75                  80  


Thr Leu Tyr Leu Gln Met His Ser Leu Lys Pro Glu Asp Thr Ala Phe 
                85                  90                  95      


Tyr Tyr Cys Ala Ala Arg Leu Val Pro Pro Gly Ile Pro Ile Glu Arg 
            100                 105                 110         


Thr Leu Glu Ser Met Arg Tyr Trp Gly Lys Gly Thr Leu Val Thr Val 
        115                 120                 125             


Ser Ser 
    130 


<210>  83
<211>  129
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody sequence

<400>  83

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Arg Ser Phe Ser Ser Tyr 
            20                  25                  30          


Thr Met Gly Thr Ile Arg Thr Gly Gly Ser Thr Asn Tyr Ala Asp Ser 
        35                  40                  45              


Val Lys Gly Ala Ile Arg Trp Ser Gly Glu Ser Pro Tyr Tyr Ala Asp 
    50                  55                  60                  


Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr 
65                  70                  75                  80  


Asn Tyr Leu Gln Met Asn Ser Leu Lys Pro Glu Leu Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Ala Ala Arg Leu Val Pro Pro Gly Ile Pro Ile Glu Arg Ser 
            100                 105                 110         


Leu Glu Asn Met Asn Tyr Trp Gly Lys Gly Thr Leu Val Thr Val Ser 
        115                 120                 125             


Ser 
    


<210>  84
<211>  121
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody sequence

<400>  84

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Ser Ile Phe Ser Ile Asn 
            20                  25                  30          


Ala Met Gly Ala Ile Arg Trp Ser Gly Glu Ser Pro Tyr Tyr Ala Asp 
        35                  40                  45              


Ser Val Lys Gly Val Ile Ser Ser Ser Gly Ser Thr Asn Tyr Ala Asp 
    50                  55                  60                  


Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr 
65                  70                  75                  80  


Ala Tyr Leu Gln Met Asn Ser Leu Lys Val Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Ala Ala His Val Ala Gly Phe Asp Glu Tyr Asn Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Gln Val Thr Val Ser Ser 
        115                 120     


<210>  85
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody sequence

<400>  85

Ser Tyr Ala Met Gly 
1               5   


<210>  86
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody sequence

<400>  86

Ala Ile Ser Trp Ser Gly Gly Thr Thr Tyr Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  87
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody sequence

<400>  87

Ser Leu Asp Cys Ser Gly Pro Gly Cys His Thr Ala Glu Tyr Asp Tyr 
1               5                   10                  15      


<210>  88
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody sequence

<400>  88

Glu Tyr Ala Met Gly 
1               5   


<210>  89
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody sequence

<400>  89

Ala Ile Ser Trp Thr Gly Ser Lys Thr Tyr Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  90
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody sequence

<400>  90

Ser Ser Asp Cys Ser Gly Pro Gly Cys His Thr Glu Glu Tyr Asp Tyr 
1               5                   10                  15      


<210>  91
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody sequence

<400>  91

Ser Tyr Ala Met Gly 
1               5   


<210>  92
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody sequence

<400>  92

Ala Val Ser Trp Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  93
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody sequence

<400>  93

Ser Gln Asp Cys Ser Gly Pro Gly Cys Tyr Thr Asn Glu Tyr Asp Ser 
1               5                   10                  15      


<210>  94
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody sequence

<400>  94

Asn Tyr Ala Met Ala 
1               5   


<210>  95
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody sequence

<400>  95

Ala Val Ser Trp Ser Gly Gly Arg Thr Tyr Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  96
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody sequence

<400>  96

Ser Leu Ser Cys Ser Gly Pro Gly Cys Ser Leu Glu Glu Tyr Asp Tyr 
1               5                   10                  15      


<210>  97
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody sequence

<400>  97

Asn Tyr Ala Met Gly 
1               5   


<210>  98
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody sequence

<400>  98

Val Ile Ser Trp Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  99
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody sequence

<400>  99

Gln Phe Ser Gly Ala Ser Thr Val Val Ala Gly Thr Ala Leu Asp Tyr 
1               5                   10                  15      


Asp Tyr 
        


<210>  100
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody sequence

<400>  100

Asn Tyr Gly Met Gly 
1               5   


<210>  101
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody sequence

<400>  101

Gly Ile Ser Trp Ser Gly Gly Ser Thr Asp Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  102
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody sequence

<400>  102

Val Phe Ser Gly Ala Glu Thr Ala Tyr Tyr Pro Ser Asp Asp Tyr Asp 
1               5                   10                  15      


Tyr 
    


<210>  103
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody sequence

<400>  103

Asn Tyr Gly Met Gly 
1               5   


<210>  104
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody sequence

<400>  104

Gly Ile Ser Trp Ser Gly Gly Ser Thr Asp Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  105
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody sequence

<400>  105

Val Phe Ser Gly Ala Glu Thr Ala Tyr Tyr Pro Ser Asp Asp Tyr Asp 
1               5                   10                  15      


Tyr 
    


<210>  106
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody sequence

<400>  106

Asn Tyr Gly Met Gly 
1               5   


<210>  107
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody sequence

<400>  107

Gly Ile Ser Trp Ser Gly Gly Ser Thr Asp Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  108
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody sequence

<400>  108

Val Phe Ser Gly Ala Glu Thr Ala Tyr Tyr Pro Ser Asp Asp Tyr Asp 
1               5                   10                  15      


Tyr 
    


<210>  109
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody sequence

<400>  109

Asn Tyr Gly Met Gly 
1               5   


<210>  110
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody sequence

<400>  110

Gly Ile Thr Trp Ser Gly Gly Ser Thr His Tyr Ala Asp Leu Val Lys 
1               5                   10                  15      


Gly 
    


<210>  111
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody sequence

<400>  111

Val Phe Ser Gly Ala Glu Thr Ala Tyr Tyr Pro Ser Thr Glu Tyr Asp 
1               5                   10                  15      


Tyr 
    


<210>  112
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody sequence

<400>  112

Asn Tyr Gly Met Gly 
1               5   


<210>  113
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody sequence

<400>  113

Gly Ile Ser Trp Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  114
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody sequence

<400>  114

Val Phe Ser Gly Ala Glu Thr Ala Gln Tyr Pro Ser Tyr Asp Tyr Asp 
1               5                   10                  15      


Tyr 
    


<210>  115
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody sequence

<400>  115

Asn Tyr Ala Met Gly 
1               5   


<210>  116
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody sequence

<400>  116

Ala Ile Ser Trp Ser Gly Gly Ser Thr Ser Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  117
<211>  21
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody sequence

<400>  117

Gln Phe Ser Gly Ala Asp Tyr Gly Phe Gly Arg Leu Gly Ile Arg Gly 
1               5                   10                  15      


Tyr Glu Tyr Asp Tyr 
            20      


<210>  118
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody sequence

<400>  118

Asn Tyr Ala Met Gly 
1               5   


<210>  119
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody sequence

<400>  119

Ala Ile Ser Trp Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  120
<211>  21
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody sequence

<400>  120

Met Phe Ser Gly Ser Glu Ser Gln Leu Val Val Val Ile Thr Asn Leu 
1               5                   10                  15      


Tyr Glu Tyr Asp Tyr 
            20      


<210>  121
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody sequence

<400>  121

Asn Tyr Ala Met Gly 
1               5   


<210>  122
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody sequence

<400>  122

Thr Ile Ser Trp Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  123
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody sequence

<400>  123

Ala Phe Ser Gly Ser Asp Tyr Ala Asn Thr Lys Lys Glu Val Glu Tyr 
1               5                   10                  15      


Asp Tyr 
        


<210>  124
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody sequence

<400>  124

Asp Tyr Cys Ile Ala 
1               5   


<210>  125
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody sequence

<400>  125

Cys Ile Thr Thr Ser Asp Gly Ser Thr Tyr Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  126
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody sequence

<400>  126

Tyr Phe Gly Tyr Gly Cys Tyr Gly Gly Ala Gln Asp Tyr Arg Ala Met 
1               5                   10                  15      


Asp Tyr 
        


<210>  127
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody sequence

<400>  127

Arg Tyr Thr Met Gly 
1               5   


<210>  128
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody sequence

<400>  128

Ala Ile Ser Trp Ser Gly Gly Arg Thr Asn Phe Ala Gly Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  129
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody sequence

<400>  129

Asp Trp Leu Pro Val Pro Gly Arg Glu Ser Tyr Asp Tyr 
1               5                   10              


<210>  130
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody sequence

<400>  130

Asn Tyr Ala Met Gly 
1               5   


<210>  131
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody sequence

<400>  131

Ala Ile Ser Trp Ser Gly Gly Met Thr Asp His Ala Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  132
<211>  21
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody sequence

<400>  132

Ala Phe Ala Gly Asp Ile Pro Tyr Gly Ser Ser Trp Tyr Gly Asp Pro 
1               5                   10                  15      


Thr Thr Tyr Asp Tyr 
            20      


<210>  133
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody sequence

<400>  133

Thr Phe Ser Met Ala 
1               5   


<210>  134
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody sequence

<400>  134

Ala Ile Asn Trp Ser Gly Gly Ser Thr Arg Tyr Ala Asp Ser Val Ser 
1               5                   10                  15      


Asp 
    


<210>  135
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody sequence

<400>  135

Arg Arg Gly Gly Ile Tyr Tyr Ser Thr Gln Asn Asp Tyr Asp Tyr 
1               5                   10                  15  


<210>  136
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody sequence

<400>  136

Asp Tyr Arg Met Gly 
1               5   


<210>  137
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody sequence

<400>  137

Thr Ile Ser Trp Ser Gly Gly Leu Thr Tyr Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  138
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody sequence

<400>  138

Gly Gly Gly Tyr Ala Gly Gly Thr Tyr Tyr His Pro Glu Glu 
1               5                   10                  


<210>  139
<211>  125
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody sequence

<400>  139

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Thr Ala Ser Gly Arg Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              


Ala Ala Ile Ser Trp Ser Gly Gly Thr Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Ser 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Phe Cys 
                85                  90                  95      


Ala Ala Ser Leu Asp Cys Ser Gly Pro Gly Cys His Thr Ala Glu Tyr 
            100                 105                 110         


Asp Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
        115                 120                 125 


<210>  140
<211>  125
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody sequence

<400>  140

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Thr Gly Arg Thr Phe Ser Glu Tyr 
            20                  25                  30          


Ala Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Ala 
        35                  40                  45              


Ala Ala Ile Ser Trp Thr Gly Ser Lys Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Ser Ser Asp Cys Ser Gly Pro Gly Cys His Thr Glu Glu Tyr 
            100                 105                 110         


Asp Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
        115                 120                 125 


<210>  141
<211>  125
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody sequence

<400>  141

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Arg Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              


Ala Ala Val Ser Trp Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Arg Asn Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Asn Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Ser Gln Asp Cys Ser Gly Pro Gly Cys Tyr Thr Asn Glu Tyr 
            100                 105                 110         


Asp Ser Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
        115                 120                 125 


<210>  142
<211>  125
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody sequence

<400>  142

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Ser Ile Phe Ser Asn Tyr 
            20                  25                  30          


Ala Met Ala Trp Phe Arg Gln Ala Pro Glu Lys Glu Arg Asp Phe Leu 
        35                  40                  45              


Ala Ala Val Ser Trp Ser Gly Gly Arg Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Asn 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Ser Leu Ser Cys Ser Gly Pro Gly Cys Ser Leu Glu Glu Tyr 
            100                 105                 110         


Asp Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
        115                 120                 125 


<210>  143
<211>  127
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody sequence

<400>  143

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Arg Pro Phe Ser Asn Tyr 
            20                  25                  30          


Ala Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              


Thr Val Ile Ser Trp Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Gln Phe Ser Gly Ala Ser Thr Val Val Ala Gly Thr Ala Leu 
            100                 105                 110         


Asp Tyr Asp Tyr Trp Gly Gln Gly Thr Arg Val Thr Val Ser Ser 
        115                 120                 125         


<210>  144
<211>  126
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody sequence

<400>  144

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Arg Pro Phe Ser Asn Tyr 
            20                  25                  30          


Gly Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Lys Arg Glu Phe Val 
        35                  40                  45              


Ala Gly Ile Ser Trp Ser Gly Gly Ser Thr Asp Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Leu Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Val Phe Ser Gly Ala Glu Thr Ala Tyr Tyr Pro Ser Asp Asp 
            100                 105                 110         


Tyr Asp Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
        115                 120                 125     


<210>  145
<211>  126
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody sequence

<400>  145

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Arg Pro Phe Ser Asn Tyr 
            20                  25                  30          


Gly Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Lys Arg Glu Phe Val 
        35                  40                  45              


Ala Gly Ile Ser Trp Ser Gly Gly Ser Thr Asp Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Val Phe Ser Gly Ala Glu Thr Ala Tyr Tyr Pro Ser Asp Asp 
            100                 105                 110         


Tyr Asp Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
        115                 120                 125     


<210>  146
<211>  126
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody sequence

<400>  146

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Arg Pro Phe Ser Asn Tyr 
            20                  25                  30          


Gly Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Lys Arg Glu Ser Val 
        35                  40                  45              


Ala Gly Ile Ser Trp Ser Gly Gly Ser Thr Asp Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Val Phe Ser Gly Ala Glu Thr Ala Tyr Tyr Pro Ser Asp Asp 
            100                 105                 110         


Tyr Asp Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
        115                 120                 125     


<210>  147
<211>  126
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody sequence

<400>  147

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Val Ser Gly Arg Pro Phe Ser Asn Tyr 
            20                  25                  30          


Gly Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              


Ala Gly Ile Thr Trp Ser Gly Gly Ser Thr His Tyr Ala Asp Leu Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val His 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Val Phe Ser Gly Ala Glu Thr Ala Tyr Tyr Pro Ser Thr Glu 
            100                 105                 110         


Tyr Asp Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
        115                 120                 125     


<210>  148
<211>  126
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody sequence

<400>  148

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Arg Pro Phe Asn Asn Tyr 
            20                  25                  30          


Gly Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              


Ala Gly Ile Ser Trp Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Val Phe Ser Gly Ala Glu Thr Ala Gln Tyr Pro Ser Tyr Asp 
            100                 105                 110         


Tyr Asp Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
        115                 120                 125     


<210>  149
<211>  130
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody sequence

<400>  149

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Arg Pro Phe Ser Asn Tyr 
            20                  25                  30          


Ala Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              


Ala Ala Ile Ser Trp Ser Gly Gly Ser Thr Ser Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Pro Lys Pro Glu Asp Thr Ala Ile Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Gln Phe Ser Gly Ala Asp Tyr Gly Phe Gly Arg Leu Gly Ile 
            100                 105                 110         


Arg Gly Tyr Glu Tyr Asp Tyr Trp Gly Gln Gly Thr Gln Val Thr Val 
        115                 120                 125             


Ser Ser 
    130 


<210>  150
<211>  130
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody sequence

<400>  150

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Arg Thr Phe Ser Asn Tyr 
            20                  25                  30          


Ala Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              


Ala Ala Ile Ser Trp Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Met Phe Ser Gly Ser Glu Ser Gln Leu Val Val Val Ile Thr 
            100                 105                 110         


Asn Leu Tyr Glu Tyr Asp Tyr Trp Gly Gln Gly Thr Gln Val Thr Val 
        115                 120                 125             


Ser Ser 
    130 


<210>  151
<211>  127
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody sequence

<400>  151

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Arg Thr Phe Ser Asn Tyr 
            20                  25                  30          


Ala Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              


Ala Thr Ile Ser Trp Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Ala Phe Ser Gly Ser Asp Tyr Ala Asn Thr Lys Lys Glu Val 
            100                 105                 110         


Glu Tyr Asp Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
        115                 120                 125         


<210>  152
<211>  127
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody sequence

<400>  152

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Asp Tyr 
            20                  25                  30          


Cys Ile Ala Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Pro Val 
        35                  40                  45              


Ser Cys Ile Thr Thr Ser Asp Gly Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Ser Asp Asn Ala Lys Asn Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Arg Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Tyr Phe Gly Tyr Gly Cys Tyr Gly Gly Ala Gln Asp Tyr Arg 
            100                 105                 110         


Ala Met Asp Tyr Trp Gly Lys Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125         


<210>  153
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody sequence

<400>  153

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Asp 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Arg Thr Phe Ser Arg Tyr 
            20                  25                  30          


Thr Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              


Ala Ala Ile Ser Trp Ser Gly Gly Arg Thr Asn Phe Ala Gly Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Asp Trp Leu Pro Val Pro Gly Arg Glu Ser Tyr Asp Tyr Trp 
            100                 105                 110         


Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
        115                 120         


<210>  154
<211>  130
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody sequence

<400>  154

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ile Ala Ser Gly Arg Thr Phe Ser Asn Tyr 
            20                  25                  30          


Ala Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              


Ala Ala Ile Ser Trp Ser Gly Gly Met Thr Asp His Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Ala Phe Ala Gly Asp Ile Pro Tyr Gly Ser Ser Trp Tyr Gly 
            100                 105                 110         


Asp Pro Thr Thr Tyr Asp Tyr Trp Gly Gln Gly Thr Gln Val Thr Val 
        115                 120                 125             


Ser Ser 
    130 


<210>  155
<211>  124
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody sequence

<400>  155

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Arg Thr Ser Ser Thr Phe 
            20                  25                  30          


Ser Met Ala Trp Phe Arg Gln Ala Pro Arg Lys Glu Arg Glu Phe Val 
        35                  40                  45              


Ala Ala Ile Asn Trp Ser Gly Gly Ser Thr Arg Tyr Ala Asp Ser Val 
    50                  55                  60                  


Ser Asp Arg Phe Ala Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Asn Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Arg Arg Gly Gly Ile Tyr Tyr Ser Thr Gln Asn Asp Tyr Asp 
            100                 105                 110         


Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
        115                 120                 


<210>  156
<211>  123
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody sequence

<400>  156

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Val Ser Val Arg Thr Phe Ser Asp Tyr 
            20                  25                  30          


Arg Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              


Ser Thr Ile Ser Trp Ser Gly Gly Leu Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Gly Gly Gly Tyr Ala Gly Gly Thr Tyr Tyr His Pro Glu Glu 
            100                 105                 110         


Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
        115                 120             


<210>  157
<211>  315
<212>  PRT
<213>  Homo sapiens

<400>  157

Met Leu Ser Leu Leu His Ala Ser Thr Leu Ala Val Leu Gly Ala Leu 
1               5                   10                  15      


Cys Val Tyr Gly Ala Gly His Leu Glu Gln Pro Gln Ile Ser Ser Thr 
            20                  25                  30          


Lys Thr Leu Ser Lys Thr Ala Arg Leu Glu Cys Val Val Ser Gly Ile 
        35                  40                  45              


Thr Ile Ser Ala Thr Ser Val Tyr Trp Tyr Arg Glu Arg Pro Gly Glu 
    50                  55                  60                  


Val Ile Gln Phe Leu Val Ser Ile Ser Tyr Asp Gly Thr Val Arg Lys 
65                  70                  75                  80  


Glu Ser Gly Ile Pro Ser Gly Lys Phe Glu Val Asp Arg Ile Pro Glu 
                85                  90                  95      


Thr Ser Thr Ser Thr Leu Thr Ile His Asn Val Glu Lys Gln Asp Ile 
            100                 105                 110         


Ala Thr Tyr Tyr Cys Ala Leu Trp Glu Ala Gln Gln Glu Leu Gly Lys 
        115                 120                 125             


Lys Ile Lys Val Phe Gly Pro Gly Thr Lys Leu Ile Ile Thr Asp Lys 
    130                 135                 140                 


Gln Leu Asp Ala Asp Val Ser Pro Lys Pro Thr Ile Phe Leu Pro Ser 
145                 150                 155                 160 


Ile Ala Glu Thr Lys Leu Gln Lys Ala Gly Thr Tyr Leu Cys Leu Leu 
                165                 170                 175     


Glu Lys Phe Phe Pro Asp Val Ile Lys Ile His Trp Glu Glu Lys Lys 
            180                 185                 190         


Ser Asn Thr Ile Leu Gly Ser Gln Glu Gly Asn Thr Met Lys Thr Asn 
        195                 200                 205             


Asp Thr Tyr Met Lys Phe Ser Trp Leu Thr Val Pro Glu Lys Ser Leu 
    210                 215                 220                 


Asp Lys Glu His Arg Cys Ile Val Arg His Glu Asn Asn Lys Asn Gly 
225                 230                 235                 240 


Val Asp Gln Glu Ile Ile Phe Pro Pro Ile Lys Thr Asp Val Ile Thr 
                245                 250                 255     


Met Asp Pro Lys Asp Asn Cys Ser Lys Asp Ala Asn Asp Thr Leu Leu 
            260                 265                 270         


Leu Gln Leu Thr Asn Thr Ser Ala Tyr Tyr Met Tyr Leu Leu Leu Leu 
        275                 280                 285             


Leu Lys Ser Val Val Tyr Phe Ala Ile Ile Thr Cys Cys Leu Leu Arg 
    290                 295                 300                 


Arg Thr Ala Phe Cys Cys Asn Gly Glu Lys Ser 
305                 310                 315 


<210>  158
<211>  292
<212>  PRT
<213>  Homo sapiens

<400>  158

Met Gln Arg Ile Ser Ser Leu Ile His Leu Ser Leu Phe Trp Ala Gly 
1               5                   10                  15      


Val Met Ser Ala Ile Glu Leu Val Pro Glu His Gln Thr Val Pro Val 
            20                  25                  30          


Ser Ile Gly Val Pro Ala Thr Leu Arg Cys Ser Met Lys Gly Glu Ala 
        35                  40                  45              


Ile Gly Asn Tyr Tyr Ile Asn Trp Tyr Arg Lys Thr Gln Gly Asn Thr 
    50                  55                  60                  


Met Thr Phe Ile Tyr Arg Glu Lys Asp Ile Tyr Gly Pro Gly Phe Lys 
65                  70                  75                  80  


Asp Asn Phe Gln Gly Asp Ile Asp Ile Ala Lys Asn Leu Ala Val Leu 
                85                  90                  95      


Lys Ile Leu Ala Pro Ser Glu Arg Asp Glu Gly Ser Tyr Tyr Cys Ala 
            100                 105                 110         


Cys Asp Thr Leu Gly Met Gly Gly Glu Tyr Thr Asp Lys Leu Ile Phe 
        115                 120                 125             


Gly Lys Gly Thr Arg Val Thr Val Glu Pro Arg Ser Gln Pro His Thr 
    130                 135                 140                 


Lys Pro Ser Val Phe Val Met Lys Asn Gly Thr Asn Val Ala Cys Leu 
145                 150                 155                 160 


Val Lys Glu Phe Tyr Pro Lys Asp Ile Arg Ile Asn Leu Val Ser Ser 
                165                 170                 175     


Lys Lys Ile Thr Glu Phe Asp Pro Ala Ile Val Ile Ser Pro Ser Gly 
            180                 185                 190         


Lys Tyr Asn Ala Val Lys Leu Gly Lys Tyr Glu Asp Ser Asn Ser Val 
        195                 200                 205             


Thr Cys Ser Val Gln His Asp Asn Lys Thr Val His Ser Thr Asp Phe 
    210                 215                 220                 


Glu Val Lys Thr Asp Ser Thr Asp His Val Lys Pro Lys Glu Thr Glu 
225                 230                 235                 240 


Asn Thr Lys Gln Pro Ser Lys Ser Cys His Lys Pro Lys Ala Ile Val 
                245                 250                 255     


His Thr Glu Lys Val Asn Met Met Ser Leu Thr Val Leu Gly Leu Arg 
            260                 265                 270         


Met Leu Phe Ala Lys Thr Val Ala Val Asn Phe Leu Leu Thr Ala Lys 
        275                 280                 285             


Leu Phe Phe Leu 
    290         


<210>  159
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  linker sequence

<400>  159

Gly Gly Gly Gly Ser 
1               5   


<210>  160
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody sequence

<400>  160

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Ser Met Phe Ser Asp Asn 
            20                  25                  30          


Val Met Gly Trp Tyr Arg Gln Ala Pro Gly Lys Gln Arg Glu Leu Val 
        35                  40                  45              


Ala Thr Ile Arg Thr Gly Gly Ser Thr Asn Tyr Ala Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys Arg 
                85                  90                  95      


His Thr Ile Pro Val Pro Ser Thr Pro Tyr Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Gln Val Thr Val Ser Ser Gly Gly Gly Gly Ser Glu Val Gln Leu 
        115                 120                 125             


Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly Ser Leu Arg Leu 
    130                 135                 140                 


Ser Cys Ala Ala Ser Gly Arg Pro Phe Ser Asn Tyr Ala Met Gly Trp 
145                 150                 155                 160 


Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val Ala Ala Ile Ser 
                165                 170                 175     


Trp Ser Gly Gly Ser Thr Ser Tyr Ala Asp Ser Val Lys Gly Arg Phe 
            180                 185                 190         


Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr Leu Gln Met Asn 
        195                 200                 205             


Ser Pro Lys Pro Glu Asp Thr Ala Ile Tyr Tyr Cys Ala Ala Gln Phe 
    210                 215                 220                 


Ser Gly Ala Asp Tyr Gly Phe Gly Arg Leu Gly Ile Arg Gly Tyr Glu 
225                 230                 235                 240 


Tyr Asp Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
                245                 250                 


<210>  161
<211>  119
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody sequence

<400>  161

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Ser Met Phe Ser Asp Asn 
            20                  25                  30          


Val Met Gly Trp Tyr Arg Gln Ala Pro Gly Lys Gln Arg Glu Leu Val 
        35                  40                  45              


Ala Thr Ile Arg Thr Gly Gly Ser Thr Asn Tyr Ala Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys Arg 
                85                  90                  95      


His Thr Ile Pro Val Pro Ser Thr Pro Tyr Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Gln Val Thr Val Ser Ser 
        115                 


<210>  162
<211>  130
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody sequence

<400>  162

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Ser Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Arg Pro Phe Ser Asn Tyr 
            20                  25                  30          


Ala Met Ser Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              


Ser Ala Ile Ser Trp Ser Gly Gly Ser Thr Ser Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Gln Phe Ser Gly Ala Asp Tyr Gly Phe Gly Arg Leu Gly Ile 
            100                 105                 110         


Arg Gly Tyr Glu Tyr Asp Tyr Trp Gly Gln Gly Thr Gln Val Thr Val 
        115                 120                 125             


Ser Ser 
    130 


<210>  163
<211>  130
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody sequence

<400>  163

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Arg Pro Phe Ser Asn Tyr 
            20                  25                  30          


Ala Met Ser Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              


Ser Ala Ile Ser Trp Ser Gly Gly Ser Thr Ser Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Gln Phe Ser Gly Ala Asp Tyr Gly Phe Gly Arg Leu Gly Ile 
            100                 105                 110         


Arg Gly Tyr Glu Tyr Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val 
        115                 120                 125             


Ser Ser 
    130 


<210>  164
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody sequence

<400>  164

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Ser Met Phe Ser Asp Asn 
            20                  25                  30          


Val Met Gly Trp Tyr Arg Gln Ala Pro Gly Lys Gln Arg Glu Leu Val 
        35                  40                  45              


Ala Thr Ile Arg Thr Gly Gly Ser Thr Asn Tyr Ala Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys Arg 
                85                  90                  95      


His Thr Ile Pro Val Pro Ser Thr Pro Tyr Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Gln Val Thr Val Ser Ser Gly Gly Gly Gly Ser Glu Val Gln Leu 
        115                 120                 125             


Leu Glu Ser Gly Gly Gly Ser Val Gln Pro Gly Gly Ser Leu Arg Leu 
    130                 135                 140                 


Ser Cys Ala Ala Ser Gly Arg Pro Phe Ser Asn Tyr Ala Met Ser Trp 
145                 150                 155                 160 


Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val Ser Ala Ile Ser 
                165                 170                 175     


Trp Ser Gly Gly Ser Thr Ser Tyr Ala Asp Ser Val Lys Gly Arg Phe 
            180                 185                 190         


Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu Gln Met Asn 
        195                 200                 205             


Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala Ala Gln Phe 
    210                 215                 220                 


Ser Gly Ala Asp Tyr Gly Phe Gly Arg Leu Gly Ile Arg Gly Tyr Glu 
225                 230                 235                 240 


Tyr Asp Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
                245                 250                 


<210>  165
<211>  264
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody sequence

<400>  165

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Val Ser Ser Phe Ser Ser Tyr 
            20                  25                  30          


Thr Met Gly Thr Ile Arg Thr Gly Gly Ser Thr Asn Tyr Ala Asp Ser 
        35                  40                  45              


Val Lys Gly Gly Ile Arg Trp Asp Asp Glu Asn Pro Tyr Tyr Ala Asp 
    50                  55                  60                  


Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr 
65                  70                  75                  80  


Leu Tyr Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Asn Tyr 
                85                  90                  95      


Tyr Cys Ala Ala Arg Leu Val Pro Pro Gly Ile Pro Phe Glu Arg Thr 
            100                 105                 110         


Leu Glu Asn Met Arg Tyr Trp Gly Lys Gly Thr Leu Val Thr Val Ser 
        115                 120                 125             


Ser Gly Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly 
    130                 135                 140                 


Leu Val Gln Ala Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly 
145                 150                 155                 160 


Arg Pro Phe Ser Asn Tyr Ala Met Gly Trp Phe Arg Gln Ala Pro Gly 
                165                 170                 175     


Lys Glu Arg Glu Phe Val Ala Ala Ile Ser Trp Ser Gly Gly Ser Thr 
            180                 185                 190         


Ser Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn 
        195                 200                 205             


Ala Lys Asn Thr Val Tyr Leu Gln Met Asn Ser Pro Lys Pro Glu Asp 
    210                 215                 220                 


Thr Ala Ile Tyr Tyr Cys Ala Ala Gln Phe Ser Gly Ala Asp Tyr Gly 
225                 230                 235                 240 


Phe Gly Arg Leu Gly Ile Arg Gly Tyr Glu Tyr Asp Tyr Trp Gly Gln 
                245                 250                 255     


Gly Thr Gln Val Thr Val Ser Ser 
            260                 


