                         SEQUENCE LISTING

<110>  David James Ballance
       John Lee

<120>  METHODS OF REVERSING TICAGRELOR ACTIVITY 

<130>  PHAS-037/01WO 309646-2316

<150>  US 62/733,892
<151>  2018-09-20

<150>  US 62/806,225
<151>  2019-02-15

<150>  US 62/836,373
<151>  2019-04-19


<160>  86    

<170>  PatentIn version 3.5

<210>  1
<211>  363
<212>  DNA
<213>  Homo sapiens

<400>  1
gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgagactc       60

tcctgtgcag cctctggatt cacctttagc agctatgcca tgagctgggt ccgccaggct      120

ccagggaagg ggctggagtg ggtctcagct attagtggta gtggtggtag cacatactac      180

gcagactccg tgaagggccg gttcaccatc tccagagaca attccaagaa cacgctgtat      240

ctgcaaatga acagcctgag agccgaggac acggccgtgt attactgtgc aacagagtac      300

gacctgcaac ggcctttcgg gtttgacttc tggggcaagg ggacaatggt caccgtctcg      360

agt                                                                    363


<210>  2
<211>  121
<212>  PRT
<213>  Homo sapiens

<400>  2

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ala Ile Ser Gly Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Thr Glu Tyr Asp Leu Gln Arg Pro Phe Gly Phe Asp Phe Trp Gly 
            100                 105                 110         


Lys Gly Thr Met Val Thr Val Ser Ser 
        115                 120     


<210>  3
<211>  5
<212>  PRT
<213>  Homo sapiens

<400>  3

Ser Tyr Ala Met Ser 
1               5   


<210>  4
<211>  17
<212>  PRT
<213>  Homo sapiens

<400>  4

Ala Ile Ser Gly Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  5
<211>  12
<212>  PRT
<213>  Homo sapiens

<400>  5

Glu Tyr Asp Leu Gln Arg Pro Phe Gly Phe Asp Phe 
1               5                   10          


<210>  6
<211>  333
<212>  DNA
<213>  Homo sapiens

<400>  6
tcctatgtgc tgactcagcc accctcagcg tctggggccc ccgggcagag ggctaccatc       60

tcctgctctg gaagcagctc caacatcgga agtaatcttg tgaactggta ccaacaattc      120

ccaggagagg cccccaagct cctcatcttt agtgacaatc aacgaccctc aggggtccct      180

gaccgattct ctggctccag gtctggcacc tcagcctccc tggccatcag tgggctccag      240

tccgaggatg aggctgatta ttactgtgca acgtgggatg acagactgga tggttatgtg      300

gtattcggcg gagggaccaa gctgaccgtc cta                                   333


<210>  7
<211>  111
<212>  PRT
<213>  Homo sapiens

<400>  7

Ser Tyr Val Leu Thr Gln Pro Pro Ser Ala Ser Gly Ala Pro Gly Gln 
1               5                   10                  15      


Arg Ala Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn 
            20                  25                  30          


Leu Val Asn Trp Tyr Gln Gln Phe Pro Gly Glu Ala Pro Lys Leu Leu 
        35                  40                  45              


Ile Phe Ser Asp Asn Gln Arg Pro Ser Gly Val Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Arg Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Gln 
65                  70                  75                  80  


Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Thr Trp Asp Asp Arg Leu 
                85                  90                  95      


Asp Gly Tyr Val Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105                 110     


<210>  8
<211>  13
<212>  PRT
<213>  Homo sapiens

<400>  8

Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn Leu Val Asn 
1               5                   10              


<210>  9
<211>  7
<212>  PRT
<213>  Homo sapiens

<400>  9

Ser Asp Asn Gln Arg Pro Ser 
1               5           


<210>  10
<211>  12
<212>  PRT
<213>  Homo sapiens

<400>  10

Ala Thr Trp Asp Asp Arg Leu Asp Gly Tyr Val Val 
1               5                   10          


<210>  11
<211>  345
<212>  DNA
<213>  Homo sapiens

<400>  11
caggtacagc tgcagcagtc aggggctgag gtgaagaagc ctggggcctc agtgaaggtt       60

tcctgcaagg cttctggata caccttcatt acctatggta ttcactgggt gcgccaggcc      120

cccggacaag ggcttgagtg gatgggatgg atcgaccccg ggcatggtta cacaaaatat      180

tcacagaagt tccagggcag agtcaccatt accagggaca catccgcgag cacagcctac      240

atggagatga gcagcctcag atctgaagac acggctgtgt attactgtgc gagagcggac      300

ctgggtgact actggggccg gggaaccctg gtcaccgtct cgagt                      345


<210>  12
<211>  115
<212>  PRT
<213>  Homo sapiens

<400>  12

Gln Val Gln Leu Gln Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Ile Thr Tyr 
            20                  25                  30          


Gly Ile His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Ile Asp Pro Gly His Gly Tyr Thr Lys Tyr Ser Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Ile Thr Arg Asp Thr Ser Ala Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Met Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Ala Asp Leu Gly Asp Tyr Trp Gly Arg Gly Thr Leu Val Thr 
            100                 105                 110         


Val Ser Ser 
        115 


<210>  13
<211>  5
<212>  PRT
<213>  Homo sapiens

<400>  13

Thr Tyr Gly Ile His 
1               5   


<210>  14
<211>  17
<212>  PRT
<213>  Homo sapiens

<400>  14

Trp Ile Asp Pro Gly His Gly Tyr Thr Lys Tyr Ser Gln Lys Phe Gln 
1               5                   10                  15      


Gly 
    


<210>  15
<211>  6
<212>  PRT
<213>  Homo sapiens

<400>  15

Ala Asp Leu Gly Asp Tyr 
1               5       


<210>  16
<211>  330
<212>  DNA
<213>  Homo sapiens

<400>  16
cagtctgtcg tgacgcagcc gccctcagtg tctgcggccc caggacagaa ggtcaccatc       60

tcctgctctg gaagcagctc caacattggg aagaattatg tttcctggtt ccagcagctc      120

ccaggtacag cccccaaact cctcatttat gacaatcata agcgaccctc agggattcct      180

gaccgattct ctgcctccaa gtctggcacg tcagccaccc tggtcatctc cggtctccag      240

actggggacg aggcccatta ttactgcgga acatgggata ccagactgag tgctggggtg      300

ttcggcggag ggaccaaggt caccgtccta                                       330


<210>  17
<211>  110
<212>  PRT
<213>  Homo sapiens

<400>  17

Gln Ser Val Val Thr Gln Pro Pro Ser Val Ser Ala Ala Pro Gly Gln 
1               5                   10                  15      


Lys Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Lys Asn 
            20                  25                  30          


Tyr Val Ser Trp Phe Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 
        35                  40                  45              


Ile Tyr Asp Asn His Lys Arg Pro Ser Gly Ile Pro Asp Arg Phe Ser 
    50                  55                  60                  


Ala Ser Lys Ser Gly Thr Ser Ala Thr Leu Val Ile Ser Gly Leu Gln 
65                  70                  75                  80  


Thr Gly Asp Glu Ala His Tyr Tyr Cys Gly Thr Trp Asp Thr Arg Leu 
                85                  90                  95      


Ser Ala Gly Val Phe Gly Gly Gly Thr Lys Val Thr Val Leu 
            100                 105                 110 


<210>  18
<211>  13
<212>  PRT
<213>  Homo sapiens

<400>  18

Ser Gly Ser Ser Ser Asn Ile Gly Lys Asn Tyr Val Ser 
1               5                   10              


<210>  19
<211>  7
<212>  PRT
<213>  Homo sapiens

<400>  19

Asp Asn His Lys Arg Pro Ser 
1               5           


<210>  20
<211>  11
<212>  PRT
<213>  Homo sapiens

<400>  20

Gly Thr Trp Asp Thr Arg Leu Ser Ala Gly Val 
1               5                   10      


<210>  21
<211>  360
<212>  DNA
<213>  Homo sapiens

<400>  21
gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgagactc       60

tcctgtgcag cctctggatt cacctttagc agctatgcca tgagctgggt ccgccaggct      120

ccagggaagg ggctggagtg ggtctcagct attagtggta gtggtggtag cacatactac      180

gcagactccg tgaagggccg gttcaccatc tccagagaca attccaagaa cacgctgtat      240

ctgcaaatga acagcctgag agccgaggac acggccgtgt attactgtgg ccatgatagt      300

agtggttact cctactcctt tgacttctgg gggcggggga ccacggtcac cgtctcgagt      360


<210>  22
<211>  120
<212>  PRT
<213>  Homo sapiens

<400>  22

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ala Ile Ser Gly Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Gly His Asp Ser Ser Gly Tyr Ser Tyr Ser Phe Asp Phe Trp Gly Arg 
            100                 105                 110         


Gly Thr Thr Val Thr Val Ser Ser 
        115                 120 


<210>  23
<211>  5
<212>  PRT
<213>  Homo sapiens

<400>  23

Ser Tyr Ala Met Ser 
1               5   


<210>  24
<211>  17
<212>  PRT
<213>  Homo sapiens

<400>  24

Ala Ile Ser Gly Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  25
<211>  11
<212>  PRT
<213>  Homo sapiens

<400>  25

Asp Ser Ser Gly Tyr Ser Tyr Ser Phe Asp Phe 
1               5                   10      


<210>  26
<211>  330
<212>  DNA
<213>  Homo sapiens

<400>  26
cagtctgtgt tgacgcagcc gccctcagcg tctgggaccc ccgggcagag ggtcaccatc       60

tcttgttctg gcaacatctc caacatcgga agtaacactg tcaactggta tcaacacgtc      120

ccaggagcgg cccccagact cctcatctat gttaatgatc agcggccgtc aggggtccct      180

gaccgattct ctggctccaa gtctggcacc tcagcctccc tggccatcag tgggctccag      240

tctgaagatg aggctgatta ttactgtgca acgtgggatg acaccctgaa tggaggggtc      300

ttcggcggag ggaccaagct gaccgtccta                                       330


<210>  27
<211>  110
<212>  PRT
<213>  Homo sapiens

<400>  27

Gln Ser Val Leu Thr Gln Pro Pro Ser Ala Ser Gly Thr Pro Gly Gln 
1               5                   10                  15      


Arg Val Thr Ile Ser Cys Ser Gly Asn Ile Ser Asn Ile Gly Ser Asn 
            20                  25                  30          


Thr Val Asn Trp Tyr Gln His Val Pro Gly Ala Ala Pro Arg Leu Leu 
        35                  40                  45              


Ile Tyr Val Asn Asp Gln Arg Pro Ser Gly Val Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Gln 
65                  70                  75                  80  


Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Thr Trp Asp Asp Thr Leu 
                85                  90                  95      


Asn Gly Gly Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105                 110 


<210>  28
<211>  13
<212>  PRT
<213>  Homo sapiens

<400>  28

Ser Gly Asn Ile Ser Asn Ile Gly Ser Asn Thr Val Asn 
1               5                   10              


<210>  29
<211>  7
<212>  PRT
<213>  Homo sapiens

<400>  29

Val Asn Asp Gln Arg Pro Ser 
1               5           


<210>  30
<211>  11
<212>  PRT
<213>  Homo sapiens

<400>  30

Ala Thr Trp Asp Asp Thr Leu Asn Gly Gly Val 
1               5                   10      


<210>  31
<211>  387
<212>  DNA
<213>  Homo sapiens

<400>  31
caggtgcagc tgcaggagtc cggggctgag gtgaagaagc ctgggtcctc ggtgagggtc       60

tcctgcaagg cttctggagg caccttcgac agttatagta tccattgggt gcgccaggcc      120

cctggacaag ggcttgagtg gatgggaggg atcatccctg cctttgggac attaagcagc      180

gcacaggact tccaggccag agtcaccatt agcgcggaca agtccacgag cacagcctat      240

atggagctga gcggcctgag atctgaggac acggccgtat attactgtgc gagagggtcc      300

catctttacg atttttggag tgcttctcat ccccccaatg atgctcttgc tatttggggc      360

caaggaaccc tggtcaccgt ctcgagt                                          387


<210>  32
<211>  129
<212>  PRT
<213>  Homo sapiens

<400>  32

Gln Val Gln Leu Gln Glu Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Arg Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Asp Ser Tyr 
            20                  25                  30          


Ser Ile His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Gly Ile Ile Pro Ala Phe Gly Thr Leu Ser Ser Ala Gln Asp Phe 
    50                  55                  60                  


Gln Ala Arg Val Thr Ile Ser Ala Asp Lys Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Gly Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Ser His Leu Tyr Asp Phe Trp Ser Ala Ser His Pro Pro 
            100                 105                 110         


Asn Asp Ala Leu Ala Ile Trp Gly Gln Gly Thr Leu Val Thr Val Ser 
        115                 120                 125             


Ser 
    


<210>  33
<211>  5
<212>  PRT
<213>  Homo sapiens

<400>  33

Ser Tyr Ser Ile His 
1               5   


<210>  34
<211>  17
<212>  PRT
<213>  Homo sapiens

<400>  34

Gly Ile Ile Pro Ala Phe Gly Thr Leu Ser Ser Ala Gln Asp Phe Gln 
1               5                   10                  15      


Ala 
    


<210>  35
<211>  20
<212>  PRT
<213>  Homo sapiens

<400>  35

Gly Ser His Leu Tyr Asp Phe Trp Ser Ala Ser His Pro Pro Asn Asp 
1               5                   10                  15      


Ala Leu Ala Ile 
            20  


<210>  36
<211>  330
<212>  DNA
<213>  Homo sapiens

<400>  36
cagtctgtcg tgacgcagcc gccctcagtg tctgcggccc caggacagaa ggtcaccatc       60

tcctgctctg gaagcaactc cgacattggc aacaattatg tgtcgtggta ccaacagctc      120

ccaggaacag cccccaaact cctcatttat gacaataata aacgaccctc agggattcct      180

gaccgattct ctggctccaa gtctggcacg tcagccaccc tggccatcac cggactccag      240

gctggggacg aggccgatta ttactgcggg acatgggata tcagcctgag cgctggcttg      300

ttcggcggag ggaccaaggt caccgtccta                                       330


<210>  37
<211>  110
<212>  PRT
<213>  Homo sapiens

<400>  37

Gln Ser Val Val Thr Gln Pro Pro Ser Val Ser Ala Ala Pro Gly Gln 
1               5                   10                  15      


Lys Val Thr Ile Ser Cys Ser Gly Ser Asn Ser Asp Ile Gly Asn Asn 
            20                  25                  30          


Tyr Val Ser Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 
        35                  40                  45              


Ile Tyr Asp Asn Asn Lys Arg Pro Ser Gly Ile Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Lys Ser Gly Thr Ser Ala Thr Leu Ala Ile Thr Gly Leu Gln 
65                  70                  75                  80  


Ala Gly Asp Glu Ala Asp Tyr Tyr Cys Gly Thr Trp Asp Ile Ser Leu 
                85                  90                  95      


Ser Ala Gly Leu Phe Gly Gly Gly Thr Lys Val Thr Val Leu 
            100                 105                 110 


<210>  38
<211>  13
<212>  PRT
<213>  Homo sapiens

<400>  38

Ser Gly Ser Asn Ser Asp Ile Gly Asn Asn Tyr Val Ser 
1               5                   10              


<210>  39
<211>  7
<212>  PRT
<213>  Homo sapiens

<400>  39

Asp Asn Asn Lys Arg Pro Ser 
1               5           


<210>  40
<211>  11
<212>  PRT
<213>  Homo sapiens

<400>  40

Gly Thr Trp Asp Ile Ser Leu Ser Ala Gly Leu 
1               5                   10      


<210>  41
<211>  387
<212>  DNA
<213>  Homo sapiens

<400>  41
caggtgcagc tgcaggagtc cggggctgag gtgaagaagc ctgggtcctc ggtgagggtc       60

tcctgcaagg cttctggagg caccttcgac agttatagta tccattgggt gcgccaggcc      120

cctggacaag ggcttgagtg gatgggaggg atcatccctg cctttgggac attaagcagc      180

gcacaggact tccaggccag agtcaccatt agcgcggaca agtccacgag cacagcctat      240

atggagctga gcggcctgag atctgaggac acggccgtat attactgtgc gagagggagc      300

ttcgactaca ggttttggag tgcttctcat ccccccaatg atgctcttgc tatttggggc      360

caaggaaccc tggtcaccgt ctcgagt                                          387


<210>  42
<211>  129
<212>  PRT
<213>  Homo sapiens

<400>  42

Gln Val Gln Leu Gln Glu Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Arg Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Asp Ser Tyr 
            20                  25                  30          


Ser Ile His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Gly Ile Ile Pro Ala Phe Gly Thr Leu Ser Ser Ala Gln Asp Phe 
    50                  55                  60                  


Gln Ala Arg Val Thr Ile Ser Ala Asp Lys Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Gly Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Ser Phe Asp Tyr Arg Phe Trp Ser Ala Ser His Pro Pro 
            100                 105                 110         


Asn Asp Ala Leu Ala Ile Trp Gly Gln Gly Thr Leu Val Thr Val Ser 
        115                 120                 125             


Ser 
    


<210>  43
<211>  5
<212>  PRT
<213>  Homo sapiens

<400>  43

Ser Tyr Ser Ile His 
1               5   


<210>  44
<211>  17
<212>  PRT
<213>  Homo sapiens

<400>  44

Gly Ile Ile Pro Ala Phe Gly Thr Leu Ser Ser Ala Gln Asp Phe Gln 
1               5                   10                  15      


Ala 
    


<210>  45
<211>  20
<212>  PRT
<213>  Homo sapiens

<400>  45

Gly Ser Phe Asp Tyr Arg Phe Trp Ser Ala Ser His Pro Pro Asn Asp 
1               5                   10                  15      


Ala Leu Ala Ile 
            20  


<210>  46
<211>  330
<212>  DNA
<213>  Homo sapiens

<400>  46
cagtctgtcg tgacgcagcc gccctcagtg tctgcggccc caggacagaa ggtcaccatc       60

tcctgctctg gaagcaactc cgacattggc aacaattatg tgtcgtggta ccaacagctc      120

ccaggaacag cccccaaact cctcatttat gacaataata aacgaccctc agggattcct      180

gaccgattct ctggctccaa gtctggcacg tcagccaccc tggccatcac cggactccag      240

gctggggacg aggccgatta ttactgcggg acatgggata tcagcctgag cgctggcttg      300

ttcggcggag ggaccaaggt caccgtccta                                       330


<210>  47
<211>  110
<212>  PRT
<213>  Homo sapiens

<400>  47

Gln Ser Val Val Thr Gln Pro Pro Ser Val Ser Ala Ala Pro Gly Gln 
1               5                   10                  15      


Lys Val Thr Ile Ser Cys Ser Gly Ser Asn Ser Asp Ile Gly Asn Asn 
            20                  25                  30          


Tyr Val Ser Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 
        35                  40                  45              


Ile Tyr Asp Asn Asn Lys Arg Pro Ser Gly Ile Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Lys Ser Gly Thr Ser Ala Thr Leu Ala Ile Thr Gly Leu Gln 
65                  70                  75                  80  


Ala Gly Asp Glu Ala Asp Tyr Tyr Cys Gly Thr Trp Asp Ile Ser Leu 
                85                  90                  95      


Ser Ala Gly Leu Phe Gly Gly Gly Thr Lys Val Thr Val Leu 
            100                 105                 110 


<210>  48
<211>  13
<212>  PRT
<213>  Homo sapiens

<400>  48

Ser Gly Ser Asn Ser Asp Ile Gly Asn Asn Tyr Val Ser 
1               5                   10              


<210>  49
<211>  7
<212>  PRT
<213>  Homo sapiens

<400>  49

Asp Asn Asn Lys Arg Pro Ser 
1               5           


<210>  50
<211>  11
<212>  PRT
<213>  Homo sapiens

<400>  50

Gly Thr Trp Asp Ile Ser Leu Ser Ala Gly Leu 
1               5                   10      


<210>  51
<211>  387
<212>  DNA
<213>  Homo sapiens

<400>  51
caggtgcagc tgcaggagtc cggggctgag gtgaagaagc ctgggtcctc ggtgagggtc       60

tcctgcaagg cttctggagg caccttcgac agttatagta tccattgggt gcgccaggcc      120

cctggacaag ggcttgagtg gatgggaggg atcatccctg cctttgggac attaagcagc      180

gcacaggact tccaggccag agtcaccatt agcgcggaca agtccacgag cacagcctat      240

atggagctga gcggcctgag atctgaggac acggccgtat attactgtgc gagaggctcc      300

ttcgactact acttttggag tgcttctcat ccccccaatg atgctcttgc tatttggggc      360

caaggaaccc tggtcaccgt ctcgagt                                          387


<210>  52
<211>  129
<212>  PRT
<213>  Homo sapiens

<400>  52

Gln Val Gln Leu Gln Glu Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Arg Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Asp Ser Tyr 
            20                  25                  30          


Ser Ile His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Gly Ile Ile Pro Ala Phe Gly Thr Leu Ser Ser Ala Gln Asp Phe 
    50                  55                  60                  


Gln Ala Arg Val Thr Ile Ser Ala Asp Lys Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Gly Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Ser Phe Asp Tyr Tyr Phe Trp Ser Ala Ser His Pro Pro 
            100                 105                 110         


Asn Asp Ala Leu Ala Ile Trp Gly Gln Gly Thr Leu Val Thr Val Ser 
        115                 120                 125             


Ser 
    


<210>  53
<211>  5
<212>  PRT
<213>  Homo sapiens

<400>  53

Ser Tyr Ser Ile His 
1               5   


<210>  54
<211>  17
<212>  PRT
<213>  Homo sapiens

<400>  54

Gly Ile Ile Pro Ala Phe Gly Thr Leu Ser Ser Ala Gln Asp Phe Gln 
1               5                   10                  15      


Ala 
    


<210>  55
<211>  20
<212>  PRT
<213>  Homo sapiens

<400>  55

Gly Ser Phe Asp Tyr Tyr Phe Trp Ser Ala Ser His Pro Pro Asn Asp 
1               5                   10                  15      


Ala Leu Ala Ile 
            20  


<210>  56
<211>  330
<212>  DNA
<213>  Homo sapiens

<400>  56
cagtctgtcg tgacgcagcc gccctcagtg tctgcggccc caggacagaa ggtcaccatc       60

tcctgctctg gaagcaactc cgacattggc aacaattatg tgtcgtggta ccaacagctc      120

ccaggaacag cccccaaact cctcatttat gacaataata aacgaccctc agggattcct      180

gaccgattct ctggctccaa gtctggcacg tcagccaccc tggccatcac cggactccag      240

gctggggacg aggccgatta ttactgcggg acatgggata tcagcctgag cgctggcttg      300

ttcggcggag ggaccaaggt caccgtccta                                       330


<210>  57
<211>  110
<212>  PRT
<213>  Homo sapiens

<400>  57

Gln Ser Val Val Thr Gln Pro Pro Ser Val Ser Ala Ala Pro Gly Gln 
1               5                   10                  15      


Lys Val Thr Ile Ser Cys Ser Gly Ser Asn Ser Asp Ile Gly Asn Asn 
            20                  25                  30          


Tyr Val Ser Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 
        35                  40                  45              


Ile Tyr Asp Asn Asn Lys Arg Pro Ser Gly Ile Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Lys Ser Gly Thr Ser Ala Thr Leu Ala Ile Thr Gly Leu Gln 
65                  70                  75                  80  


Ala Gly Asp Glu Ala Asp Tyr Tyr Cys Gly Thr Trp Asp Ile Ser Leu 
                85                  90                  95      


Ser Ala Gly Leu Phe Gly Gly Gly Thr Lys Val Thr Val Leu 
            100                 105                 110 


<210>  58
<211>  13
<212>  PRT
<213>  Homo sapiens

<400>  58

Ser Gly Ser Asn Ser Asp Ile Gly Asn Asn Tyr Val Ser 
1               5                   10              


<210>  59
<211>  7
<212>  PRT
<213>  Homo sapiens

<400>  59

Asp Asn Asn Lys Arg Pro Ser 
1               5           


<210>  60
<211>  11
<212>  PRT
<213>  Homo sapiens

<400>  60

Gly Thr Trp Asp Ile Ser Leu Ser Ala Gly Leu 
1               5                   10      


<210>  61
<211>  387
<212>  DNA
<213>  Homo sapiens

<400>  61
caggtgcagc tgcaggagtc cggggctgag gtgaagaagc ctgggtcctc ggtgagggtc       60

tcctgcaagg cttctggagg caccttcgac agttatagta tccattgggt gcgccaggcc      120

cctggacaag ggcttgagtg gatgggaggg atcatccctg cctttgggac attaagcagc      180

gcacaggact tccaggccag agtcaccatt agcgcggaca agtccacgag cacagcctat      240

atggagctga gcggcctgag atctgaggac acggccgtat attactgtgc gagagggtcc      300

catctttacg atttttggag tgcttctcat ccccccaatg atgctcttgc tatttggggc      360

caaggaaccc tggtcaccgt ctcgagt                                          387


<210>  62
<211>  129
<212>  PRT
<213>  Homo sapiens

<400>  62

Gln Val Gln Leu Gln Glu Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Arg Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Asp Ser Tyr 
            20                  25                  30          


Ser Ile His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Gly Ile Ile Pro Ala Phe Gly Thr Leu Ser Ser Ala Gln Asp Phe 
    50                  55                  60                  


Gln Ala Arg Val Thr Ile Ser Ala Asp Lys Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Gly Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Ser His Leu Tyr Asp Phe Trp Ser Ala Ser His Pro Pro 
            100                 105                 110         


Asn Asp Ala Leu Ala Ile Trp Gly Gln Gly Thr Leu Val Thr Val Ser 
        115                 120                 125             


Ser 
    


<210>  63
<211>  5
<212>  PRT
<213>  Homo sapiens

<400>  63

Ser Tyr Ser Ile His 
1               5   


<210>  64
<211>  17
<212>  PRT
<213>  Homo sapiens

<400>  64

Gly Ile Ile Pro Ala Phe Gly Thr Leu Ser Ser Ala Gln Asp Phe Gln 
1               5                   10                  15      


Ala 
    


<210>  65
<211>  20
<212>  PRT
<213>  Homo sapiens

<400>  65

Gly Ser His Leu Tyr Asp Phe Trp Ser Ala Ser His Pro Pro Asn Asp 
1               5                   10                  15      


Ala Leu Ala Ile 
            20  


<210>  66
<211>  330
<212>  DNA
<213>  Homo sapiens

<400>  66
cagtctgtcg tgacgcagcc gccctcagtg tctgcggccc caggacagaa ggtcaccatc       60

tcctgctctg gaagcaactc cgacattggc aacaattatg tgtcgtggta ccaacagctc      120

ccaggaacag cccccaaact cctcatttat gacaataata aacgaccctc agggattcct      180

gaccgattct ctggctccaa gtctggcacg tcagccaccc tggccatcac cggactccag      240

gctggggacg aggccgatta ttactgcggg acatggctgt acgaccgggc cgtcggcttg      300

ttcggcggag ggaccaaggt caccgtccta                                       330


<210>  67
<211>  110
<212>  PRT
<213>  Homo sapiens

<400>  67

Gln Ser Val Val Thr Gln Pro Pro Ser Val Ser Ala Ala Pro Gly Gln 
1               5                   10                  15      


Lys Val Thr Ile Ser Cys Ser Gly Ser Asn Ser Asp Ile Gly Asn Asn 
            20                  25                  30          


Tyr Val Ser Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 
        35                  40                  45              


Ile Tyr Asp Asn Asn Lys Arg Pro Ser Gly Ile Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Lys Ser Gly Thr Ser Ala Thr Leu Ala Ile Thr Gly Leu Gln 
65                  70                  75                  80  


Ala Gly Asp Glu Ala Asp Tyr Tyr Cys Gly Thr Trp Leu Tyr Asp Arg 
                85                  90                  95      


Ala Val Gly Leu Phe Gly Gly Gly Thr Lys Val Thr Val Leu 
            100                 105                 110 


<210>  68
<211>  13
<212>  PRT
<213>  Homo sapiens

<400>  68

Ser Gly Ser Asn Ser Asp Ile Gly Asn Asn Tyr Val Ser 
1               5                   10              


<210>  69
<211>  7
<212>  PRT
<213>  Homo sapiens

<400>  69

Asp Asn Asn Lys Arg Pro Ser 
1               5           


<210>  70
<211>  11
<212>  PRT
<213>  Homo sapiens

<400>  70

Gly Thr Trp Leu Tyr Asp Arg Ala Val Gly Leu 
1               5                   10      


<210>  71
<211>  387
<212>  DNA
<213>  Homo sapiens

<400>  71
caggtgcagc tgcaggagtc cggggctgag gtgaagaagc ctgggtcctc ggtgagggtc       60

tcctgcaagg cttctggagg caccttcgac agttatagta tccattgggt gcgccaggcc      120

cctggacaag ggcttgagtg gatgggaggg atcatccctg cctttgggac attaagcagc      180

gcacaggact tccaggccag agtcaccatt agcgcggaca agtccacgag cacagcctat      240

atggagctga gcggcctgag atctgaggac acggccgtat attactgtgc gagaggctcc      300

ttcgactact acttttggag tgcttctcat ccccccaatg atgctcttgc tatttggggc      360

caaggaaccc tggtcaccgt ctcgagt                                          387


<210>  72
<211>  129
<212>  PRT
<213>  Homo sapiens

<400>  72

Gln Val Gln Leu Gln Glu Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Arg Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Asp Ser Tyr 
            20                  25                  30          


Ser Ile His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Gly Ile Ile Pro Ala Phe Gly Thr Leu Ser Ser Ala Gln Asp Phe 
    50                  55                  60                  


Gln Ala Arg Val Thr Ile Ser Ala Asp Lys Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Gly Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Ser Phe Asp Tyr Tyr Phe Trp Ser Ala Ser His Pro Pro 
            100                 105                 110         


Asn Asp Ala Leu Ala Ile Trp Gly Gln Gly Thr Leu Val Thr Val Ser 
        115                 120                 125             


Ser 
    


<210>  73
<211>  5
<212>  PRT
<213>  Homo sapiens

<400>  73

Ser Tyr Ser Ile His 
1               5 


<210>  74
<211>  17
<212>  PRT
<213>  Homo sapiens

<400>  74

Gly Ile Ile Pro Ala Phe Gly Thr Leu Ser Ser Ala Gln Asp Phe Gln 
1               5                   10                  15      


Ala 
    


<210>  75
<211>  20
<212>  PRT
<213>  Homo sapiens

<400>  75

Gly Ser Phe Asp Tyr Tyr Phe Trp Ser Ala Ser His Pro Pro Asn Asp 
1               5                   10                  15      


Ala Leu Ala Ile 
            20  


<210>  76
<211>  330
<212>  DNA
<213>  Homo sapiens

<400>  76
cagtctgtcg tgacgcagcc gccctcagtg tctgcggccc caggacagaa ggtcaccatc       60

tcctgctctg gaagcaactc cgacattggc aacaattatg tgtcgtggta ccaacagctc      120

ccaggaacag cccccaaact cctcatttat gacaataata aacgaccctc agggattcct      180

gaccgattct ctggctccaa gtctggcacg tcagccaccc tggccatcac cggactccag      240

gctggggacg aggccgatta ttactgcggg acatggctgt acgaccgggc cgtcggcttg      300

ttcggcggag ggaccaaggt caccgtccta                                       330


<210>  77
<211>  110
<212>  PRT
<213>  Homo sapiens

<400>  77

Gln Ser Val Val Thr Gln Pro Pro Ser Val Ser Ala Ala Pro Gly Gln 
1               5                   10                  15      


Lys Val Thr Ile Ser Cys Ser Gly Ser Asn Ser Asp Ile Gly Asn Asn 
            20                  25                  30          


Tyr Val Ser Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 
        35                  40                  45              


Ile Tyr Asp Asn Asn Lys Arg Pro Ser Gly Ile Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Lys Ser Gly Thr Ser Ala Thr Leu Ala Ile Thr Gly Leu Gln 
65                  70                  75                  80  


Ala Gly Asp Glu Ala Asp Tyr Tyr Cys Gly Thr Trp Leu Tyr Asp Arg 
                85                  90                  95      


Ala Val Gly Leu Phe Gly Gly Gly Thr Lys Val Thr Val Leu 
            100                 105                 110 


<210>  78
<211>  13
<212>  PRT
<213>  Homo sapiens

<400>  78

Ser Gly Ser Asn Ser Asp Ile Gly Asn Asn Tyr Val Ser 
1               5                   10              


<210>  79
<211>  7
<212>  PRT
<213>  Homo sapiens

<400>  79

Asp Asn Asn Lys Arg Pro Ser 
1               5           


<210>  80
<211>  11
<212>  PRT
<213>  Homo sapiens

<400>  80

Gly Thr Trp Leu Tyr Asp Arg Ala Val Gly Leu 
1               5                   10      

<210>  81
<211>  234
<212>  PRT
<213>  Homo sapiens

<400>  81

Gln Val Gln Leu Gln Glu Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Arg Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Asp Ser Tyr 
            20                  25                  30          


Ser Ile His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Gly Ile Ile Pro Ala Phe Gly Thr Leu Ser Ser Ala Gln Asp Phe 
    50                  55                  60                  


Gln Ala Arg Val Thr Ile Ser Ala Asp Lys Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Gly Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Ser Phe Asp Tyr Tyr Phe Trp Ser Ala Ser His Pro Pro 
            100                 105                 110         


Asn Asp Ala Leu Ala Ile Trp Gly Gln Gly Thr Leu Val Thr Val Ser 
        115                 120                 125             


Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser 
    130                 135                 140                 


Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp 
145                 150                 155                 160 


Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr 
                165                 170                 175     


Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr 
            180                 185                 190         


Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln 
        195                 200                 205             


Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp 
    210                 215                 220                 


Lys Arg Val Glu Pro Lys Ser Cys Asp Lys 
225                 230                 


<210>  82
<211>  216
<212>  PRT
<213>  Homo sapiens

<400>  82

Gln Ser Val Val Thr Gln Pro Pro Ser Val Ser Ala Ala Pro Gly Gln 
1               5                   10                  15      


Lys Val Thr Ile Ser Cys Ser Gly Ser Asn Ser Asp Ile Gly Asn Asn 
            20                  25                  30          


Tyr Val Ser Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 
        35                  40                  45              


Ile Tyr Asp Asn Asn Lys Arg Pro Ser Gly Ile Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Lys Ser Gly Thr Ser Ala Thr Leu Ala Ile Thr Gly Leu Gln 
65                  70                  75                  80  


Ala Gly Asp Glu Ala Asp Tyr Tyr Cys Gly Thr Trp Leu Tyr Asp Arg 
                85                  90                  95      


Ala Val Gly Leu Phe Gly Gly Gly Thr Lys Val Thr Val Leu Gly Gln 
            100                 105                 110         


Pro Lys Ala Ala Pro Ser Val Thr Leu Phe Pro Pro Ser Ser Glu Glu 
        115                 120                 125             


Leu Gln Ala Asn Lys Ala Thr Leu Val Cys Leu Ile Ser Asp Phe Tyr 
    130                 135                 140                 


Pro Gly Ala Val Thr Val Ala Trp Lys Ala Asp Ser Ser Pro Val Lys 
145                 150                 155                 160 


Ala Gly Val Glu Thr Thr Thr Pro Ser Lys Gln Ser Asn Asn Lys Tyr 
                165                 170                 175     


Ala Ala Ser Ser Tyr Leu Ser Leu Thr Pro Glu Gln Trp Lys Ser His 
            180                 185                 190         


Arg Ser Tyr Ser Cys Gln Val Thr His Glu Gly Ser Thr Val Glu Lys 
        195                 200                 205             


Thr Val Ala Pro Thr Glu Cys Ser 
    210                 215  


<210>  83
<211>  234
<212>  PRT
<213>  Homo sapiens

<220>
<223>  PB2452 VH with CH1

<400>  83

Gln Val Gln Leu Gln Glu Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Arg Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Asp Ser Tyr 
            20                  25                  30          


Ser Ile His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Gly Ile Ile Pro Ala Phe Gly Thr Leu Ser Ser Ala Gln Asp Phe 
    50                  55                  60                  


Gln Ala Arg Val Thr Ile Ser Ala Asp Lys Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Gly Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Ser Phe Asp Tyr Tyr Phe Trp Ser Ala Ser His Pro Pro 
            100                 105                 110         


Asn Asp Ala Leu Ala Ile Trp Gly Gln Gly Thr Leu Val Thr Val Ser 
        115                 120                 125             


Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser 
    130                 135                 140                 


Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp 
145                 150                 155                 160 


Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr 
                165                 170                 175     


Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr 
            180                 185                 190         


Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln 
        195                 200                 205             


Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp 
    210                 215                 220                 


Lys Arg Val Glu Pro Lys Ser Cys Asp Lys 
225                 230                 


<210>  84
<211>  702
<212>  DNA
<213>  Homo sapiens

<220>
<223>  cDNA encoding PB2452 VH with CH1

<400>  84
caggttcaat tgcaagaaag cggtgcagaa gttaaaaaac cgggtagcag cgttcgtgtt       60

agctgtaaag caagcggtgg cacctttgat agctatagca ttcattgggt tcgtcaggca      120

ccgggtcagg gtctggaatg gatgggtggt attattccgg catttggcac cctgagcagc      180

gcacaggatt ttcaggcacg tgttaccatt agcgcagata aaagcaccag caccgcatat      240

atggaactga gcggtctgcg tagcgaagat accgcagtgt attattgtgc acgtggtagc      300

ttcgattatt acttttggag cgcaagccat ccgcctaatg atgcactggc aatttggggt      360

cagggcaccc tggttaccgt tagcagcgca agcaccaaag gtccgagcgt ttttccgctg      420

gcaccgagca gcaaaagcac cagtggtggc accgcagcac tgggttgtct ggttaaagat      480

tattttccgg aaccggttac cgtgagctgg aatagcggtg cactgaccag cggtgttcat      540

acctttccgg cagttctgca gagcagcggt ctgtatagcc tgagcagcgt tgttaccgtt      600

ccgagcagca gcctgggcac ccagacctat atttgtaatg ttaatcataa accgagcaat      660

accaaagtgg ataaacgtgt tgaaccgaaa agctgcgata aa                         702


<210>  85
<211>  216
<212>  PRT
<213>  Homo sapiens

<220>
<223>  PB2452 VL with CL

<400>  85

Gln Ser Val Val Thr Gln Pro Pro Ser Val Ser Ala Ala Pro Gly Gln 
1               5                   10                  15      


Lys Val Thr Ile Ser Cys Ser Gly Ser Asn Ser Asp Ile Gly Asn Asn 
            20                  25                  30          


Tyr Val Ser Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 
        35                  40                  45              


Ile Tyr Asp Asn Asn Lys Arg Pro Ser Gly Ile Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Lys Ser Gly Thr Ser Ala Thr Leu Ala Ile Thr Gly Leu Gln 
65                  70                  75                  80  


Ala Gly Asp Glu Ala Asp Tyr Tyr Cys Gly Thr Trp Leu Tyr Asp Arg 
                85                  90                  95      


Ala Val Gly Leu Phe Gly Gly Gly Thr Lys Val Thr Val Leu Gly Gln 
            100                 105                 110         


Pro Lys Ala Ala Pro Ser Val Thr Leu Phe Pro Pro Ser Ser Glu Glu 
        115                 120                 125             


Leu Gln Ala Asn Lys Ala Thr Leu Val Cys Leu Ile Ser Asp Phe Tyr 
    130                 135                 140                 


Pro Gly Ala Val Thr Val Ala Trp Lys Ala Asp Ser Ser Pro Val Lys 
145                 150                 155                 160 


Ala Gly Val Glu Thr Thr Thr Pro Ser Lys Gln Ser Asn Asn Lys Tyr 
                165                 170                 175     


Ala Ala Ser Ser Tyr Leu Ser Leu Thr Pro Glu Gln Trp Lys Ser His 
            180                 185                 190         


Arg Ser Tyr Ser Cys Gln Val Thr His Glu Gly Ser Thr Val Glu Lys 
        195                 200                 205             


Thr Val Ala Pro Thr Glu Cys Ser 
    210                 215     


<210>  86
<211>  648
<212>  DNA
<213>  Homo sapiens

<220>
<223>  cDNA encoding PB2352 VL with CL

<400>  86
cagagcgttg tgacccagcc tccgagcgtt agcgcagctc cgggtcagaa agtgaccatt       60

agctgtagcg gtagcaatag cgatattggc aataactatg ttagctggta tcagcagctg      120

cctggcaccg caccgaaact gctgatttat gataataaca aacgtccgag cggtattccg      180

gatcgtttta gcggtagtaa aagcggcacc agcgcaaccc tggcaattac cggtctgcaa      240

gccggtgatg aagcagatta ttattgtggc acctggctgt atgatcgtgc agttggtctg      300

tttggtggtg gcaccaaagt taccgttctg ggtcagccga aagcagcacc gagcgttacc      360

ctgtttccgc ctagcagcga agaactgcag gcaaataaag caaccctggt ttgtctgatc      420

agcgattttt atccgggtgc agttaccgtt gcatggaaag cagatagcag tccggttaaa      480

gccggtgttg aaaccaccac cccgagcaaa cagagcaata acaaatatgc agcaagcagc      540

tatctgagcc tgacaccgga acagtggaaa agccatcgta gctatagctg tcaggttacc      600

catgaaggta gcaccgttga aaaaaccgtt gcaccgaccg aatgtagc                   648





