                         SEQUENCE LISTING

<110>  Lentigen Technology, Inc.
 
<120>  COMPOSITIONS AND METHODS FOR TREATING CANCER WITH ANTI-CD123 
       IMMUNOTHERAPY

<130>  42449-0030WO1

<150>  US 62/734,106
<151>  2018-09-20

<160>  112   

<170>  PatentIn version 3.5

<210>  1
<211>  729
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CD123 hScFv binder M12301

<400>  1
gaagtgcaac tcgtccaaag cggagctgaa gtgaagaaac caggcggatc cctgagactg       60

tcttgcgccg catcgggctt caccttctcc tcgtattcca tgaactgggt cagacaggcc      120

cctggaaagg gtctggaatg ggtgtcctcc atttcctcct cgtcgagcta catctactac      180

gccgactccg tgaaggggcg cttcacaatc tcccgggaca acgcgaagaa ctccctgtac      240

ctccaaatga actccctgag ggccgaggat actgccgtgt actactgcgc catcgagagc      300

tggggctccc tcgactattg gggccaggga accctggtca ccgtgtcatc cggcggtgga      360

ggatcgggtg gtggcggatc cggaggaggg ggatcccaga gcgtgctgac ccaacccccg      420

tcagtgtcag ccgcgcctgg acagaaggtc accatcagct gtagcggctc atcctccaat      480

atcggcgacg attacgtgtc ctggtaccag cagcttcctg gaaccgctcc caagctcctg      540

atctacgaca accacaagcg cccgtcggga attccggacc ggtttagcgg ttcaaagtcc      600

gggactagcg cgactctggg gattaccgga ctgcagacgg gcgacgaagc cgattactac      660

tgcgggactt gggatgactc gcttagcgga gtggtgttcg gtggcgggac caagctcact      720

gtgttggga                                                              729


<210>  2
<211>  243
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD123 hScFv binder M12301

<400>  2

Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ser Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ser Ile Ser Ser Ser Ser Ser Tyr Ile Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ile Glu Ser Trp Gly Ser Leu Asp Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         


Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
        115                 120                 125             


Gly Gly Gly Ser Gln Ser Val Leu Thr Gln Pro Pro Ser Val Ser Ala 
    130                 135                 140                 


Ala Pro Gly Gln Lys Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn 
145                 150                 155                 160 


Ile Gly Asp Asp Tyr Val Ser Trp Tyr Gln Gln Leu Pro Gly Thr Ala 
                165                 170                 175     


Pro Lys Leu Leu Ile Tyr Asp Asn His Lys Arg Pro Ser Gly Ile Pro 
            180                 185                 190         


Asp Arg Phe Ser Gly Ser Lys Ser Gly Thr Ser Ala Thr Leu Gly Ile 
        195                 200                 205             


Thr Gly Leu Gln Thr Gly Asp Glu Ala Asp Tyr Tyr Cys Gly Thr Trp 
    210                 215                 220                 


Asp Asp Ser Leu Ser Gly Val Val Phe Gly Gly Gly Thr Lys Leu Thr 
225                 230                 235                 240 


Val Leu Gly 
            


<210>  3
<211>  720
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CD123 hScFv binder M12303

<400>  3
gaagtgcaac tcgtcgaaac tggagccgaa gtgaaaaagc ctggagcgtc cgtcaaagtg       60

tcgtgcaagg cctccggcta caccttcacg acctactacg tgcactgggt cagacaggct      120

ccgggtcaag ggctggagtg gatgggcatc attaacccct ccggtggaag cacctcctat      180

gcgcaaaagt tccagggtcg cgtcaccatg actcgcgata cctccacttc cactgtgtac      240

atggaactga gctccctgag gtccgaggac accgccgtgt actactgcgc acgggatgga      300

ggcttgggcg gctacgaggc ttggggacag ggcaccctcg tgactgtgtc aagcggaggg      360

ggtggatccg gagggggagg atcaggcggt ggtggaagcg atatccagct tacccagtcg      420

ccttccgcgc tgtctgcatc ggccggcgac agagtgacaa ttacctgtca agccagccag      480

gacatctcca actatctgaa ctggtaccag cagaagcccg gaaaggctcc gaagctgctg      540

atctacgacg ccagcaacct ggaacggggc gtgccatcac ggttctcggg atcagggtcg      600

ggcactgagt tcaccttcac catctcctcc ctccaacccg aggacattgc cacctactac      660

tgccagcagt acgacaacct cccgatcacc tttggacagg ggactcgcct ggaaatcaag      720


<210>  4
<211>  240
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD123 hScFv binder M12303

<400>  4

Glu Val Gln Leu Val Glu Thr Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Thr Tyr 
            20                  25                  30          


Tyr Val His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Ile Ile Asn Pro Ser Gly Gly Ser Thr Ser Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Met Thr Arg Asp Thr Ser Thr Ser Thr Val Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Gly Gly Leu Gly Gly Tyr Glu Ala Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
        115                 120                 125             


Gly Gly Gly Gly Ser Asp Ile Gln Leu Thr Gln Ser Pro Ser Ala Leu 
    130                 135                 140                 


Ser Ala Ser Ala Gly Asp Arg Val Thr Ile Thr Cys Gln Ala Ser Gln 
145                 150                 155                 160 


Asp Ile Ser Asn Tyr Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala 
                165                 170                 175     


Pro Lys Leu Leu Ile Tyr Asp Ala Ser Asn Leu Glu Arg Gly Val Pro 
            180                 185                 190         


Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Glu Phe Thr Phe Thr Ile 
        195                 200                 205             


Ser Ser Leu Gln Pro Glu Asp Ile Ala Thr Tyr Tyr Cys Gln Gln Tyr 
    210                 215                 220                 


Asp Asn Leu Pro Ile Thr Phe Gly Gln Gly Thr Arg Leu Glu Ile Lys 
225                 230                 235                 240 


<210>  5
<211>  759
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CD123 hScFv binder M12304

<400>  5
gaagtgcaat tggtccagag cggaggagga cttgtgaagc caggcggatc cctgagattg       60

tcatgcgccg catcggggtt caccttttcc tcctactcca tgaactgggt cagacaggcg      120

cccggaaagg gacttgaatg ggtgtcgtcc atttcctcct cctcgtccta catctactac      180

gccgactccg tgaagggccg cttcaccatc tcccgggaca acgccaagaa cagcctgtat      240

ctccaaatga actccctgcg ggccgaagat actgctgtgt attactgcgc tcgggacttc      300

ccgtacgact catcgggcta ttactcggac gcgttcgata tctggggcca gggaactatg      360

gtcaccgtca gctctggtgg cggtggttcc ggagggggtg gatccggtgg cggaggatca      420

gagattgtgc tgacccagtc cccgctgtca ctgcccgtga ctccgggaga gcctgcctcg      480

atctcgtgtc ggtccagcca gtccctgctg cactcgaatg ggtacaacta cctcgattgg      540

tacctccaaa agcctgggca gtcaccccaa ctgctgatct acctcgggag caacagagcc      600

agcggagtgc ctgaccgctt tagcggttcc ggatccggca ccgacttcac cctgaaaatc      660

agccgggtgg aagccgagga tgtcggcgtg tactactgca tgcaggcact gcagactctg      720

gggtacacct tcggccaggg cacgaagctc gagatcaag                             759


<210>  6
<211>  253
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD123 hScFv binder M12304

<400>  6

Glu Val Gln Leu Val Gln Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ser Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ser Ile Ser Ser Ser Ser Ser Tyr Ile Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Phe Pro Tyr Asp Ser Ser Gly Tyr Tyr Ser Asp Ala Phe 
            100                 105                 110         


Asp Ile Trp Gly Gln Gly Thr Met Val Thr Val Ser Ser Gly Gly Gly 
        115                 120                 125             


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Ile Val Leu 
    130                 135                 140                 


Thr Gln Ser Pro Leu Ser Leu Pro Val Thr Pro Gly Glu Pro Ala Ser 
145                 150                 155                 160 


Ile Ser Cys Arg Ser Ser Gln Ser Leu Leu His Ser Asn Gly Tyr Asn 
                165                 170                 175     


Tyr Leu Asp Trp Tyr Leu Gln Lys Pro Gly Gln Ser Pro Gln Leu Leu 
            180                 185                 190         


Ile Tyr Leu Gly Ser Asn Arg Ala Ser Gly Val Pro Asp Arg Phe Ser 
        195                 200                 205             


Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile Ser Arg Val Glu 
    210                 215                 220                 


Ala Glu Asp Val Gly Val Tyr Tyr Cys Met Gln Ala Leu Gln Thr Leu 
225                 230                 235                 240 


Gly Tyr Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
                245                 250             


<210>  7
<211>  747
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CD123 hScFv binder M12305

<400>  7
caagtgcaac tcgtccaatc cggtgccgaa gtcaagaagc ctggttcctc cgtgaaagtg       60

tcgtgcaaag ccagcggcgg gacttttagc tcctacgcga tcagctgggt cagacaggcc      120

cctggacaag gcctcgagtg gatgggcggc atcattccga ttttcggtac cgccaactac      180

gcccagaagt tccagggacg cgtgaccatt actaccgacg agagcacctc aaccgcatac      240

atggaactgt ccagcctgcg ctccgaggac acggctgtgt actattgcgc cagacgggga      300

tggggaggat tctcctccgg ctccgcattc gacatctggg gacagggcac tatggtcact      360

gtgtcatccg ggggaggagg atcaggcggt ggaggatccg gtggtggcgg atccaacttc      420

atgctgaccc agccccactc agtgtcggaa tcgcccggca acaccgtgac tatcagctgc      480

accggatcca gcgggaccat cggctctaat ttcgtgcagt ggtaccagca gtccccaggg      540

agagctccga ccctgttgat ctacgaggac acaaagcggc caagcggagt gccgcctaga      600

ttcgccggct ccgtggattc ctcgtccaac tcggcgtcgc tgaccatcag cggactcaag      660

actgaagatg aagccgacta ctactgtcag tcctacgact cgagcaactg ggtgtttggg      720

ggcgggacta agctgaccgt gcttgga                                          747


<210>  8
<211>  249
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD123 hScFv binder M12305

<400>  8

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Gly Ile Ile Pro Ile Phe Gly Thr Ala Asn Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Ile Thr Thr Asp Glu Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Arg Gly Trp Gly Gly Phe Ser Ser Gly Ser Ala Phe Asp Ile 
            100                 105                 110         


Trp Gly Gln Gly Thr Met Val Thr Val Ser Ser Gly Gly Gly Gly Ser 
        115                 120                 125             


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asn Phe Met Leu Thr Gln 
    130                 135                 140                 


Pro His Ser Val Ser Glu Ser Pro Gly Asn Thr Val Thr Ile Ser Cys 
145                 150                 155                 160 


Thr Gly Ser Ser Gly Thr Ile Gly Ser Asn Phe Val Gln Trp Tyr Gln 
                165                 170                 175     


Gln Ser Pro Gly Arg Ala Pro Thr Leu Leu Ile Tyr Glu Asp Thr Lys 
            180                 185                 190         


Arg Pro Ser Gly Val Pro Pro Arg Phe Ala Gly Ser Val Asp Ser Ser 
        195                 200                 205             


Ser Asn Ser Ala Ser Leu Thr Ile Ser Gly Leu Lys Thr Glu Asp Glu 
    210                 215                 220                 


Ala Asp Tyr Tyr Cys Gln Ser Tyr Asp Ser Ser Asn Trp Val Phe Gly 
225                 230                 235                 240 


Gly Gly Thr Lys Leu Thr Val Leu Gly 
                245                 


<210>  9
<211>  735
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CD123 hScFv binder M12306

<400>  9
gaagtccaat tggtgcagag cggatccgaa cttaagaaac ctggcgcgag cgtgaaagtg       60

tcctgcaagg cctccggagg gactttctcg tcgtacgcca ttagctgggt ccgccaagct      120

cctggccaag gcctggagtg gatgggcggg attatcccca tcttcgggac tgcgaactac      180

gcccagaagt ttcagggccg ggtcactatc accgccgacg aatcaacctc gaccgcctac      240

atggaactgt cctcgcttcg gtccgaggat actgccgtgt actattgtgc ctcaacggcc      300

agacgcggat gggacaccgc tggtccgctc gattactggg gccagggaac cctcgtgacc      360

gtcagctccg gaggaggagg ctccggtggt ggaggatccg ggggtggtgg atccgacatc      420

caaatgaccc agtccccctc gtccctgagc gcctctgtgg gcgacagagt gacaattgca      480

tgcagggcct cacagactat ctcccgctac ctgaactggt accagcagaa gccaggaaag      540

gcccctaagc tgctcatcta cgctgcgtcc tcgctccaat ccggggtgtc ctcacggttt      600

tccggatcgg gttccggcac cgagttcacc ctgaccatca gcagcctgca gcccgaggac      660

ttcgcaacct acttctgcca gcaaacctac tccccgccga ttacgttcgg acaggggact      720

cggctggaaa tcaag                                                       735


<210>  10
<211>  245
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD123 hScFv binder M12306

<400>  10

Glu Val Gln Leu Val Gln Ser Gly Ser Glu Leu Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Gly Ile Ile Pro Ile Phe Gly Thr Ala Asn Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Ile Thr Ala Asp Glu Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ser Thr Ala Arg Arg Gly Trp Asp Thr Ala Gly Pro Leu Asp Tyr 
            100                 105                 110         


Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser 
        115                 120                 125             


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Gln Met Thr Gln 
    130                 135                 140                 


Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Ala 
145                 150                 155                 160 


Cys Arg Ala Ser Gln Thr Ile Ser Arg Tyr Leu Asn Trp Tyr Gln Gln 
                165                 170                 175     


Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr Ala Ala Ser Ser Leu 
            180                 185                 190         


Gln Ser Gly Val Ser Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Glu 
        195                 200                 205             


Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr 
    210                 215                 220                 


Phe Cys Gln Gln Thr Tyr Ser Pro Pro Ile Thr Phe Gly Gln Gly Thr 
225                 230                 235                 240 


Arg Leu Glu Ile Lys 
                245 


<210>  11
<211>  729
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CD123 hScFv binder M12308

<400>  11
gaagtgcaac tcgtcgaaac aggggcagaa gtgaaaaacc caggctcaag cgtgaaagtg       60

tcgtgcaagg cttcgggcgg aactctgtcc aactacgcca tctcctgggt ccgccaagct      120

ccgggaaagg gcctcgagtg gatgggcgga atcattccca ttttcgggac cgccaactac      180

gcgcaaaagt tccagggccg ggtcactatc accgcggacg aaagcaccag caccgcctac      240

atggaactgt cctccctgcg ctccgaggac actgccgtgt actattgcgc ccggaggtca      300

tcgtggtacc ccgagggctg cttccagcac tggggacagg gcactctcgt gaccgtgtcg      360

tcgggtggtg gtggatcagg agggggagga tccggaggag gcggaagcga tattcagctg      420

acccagtcac cgagctccct gtccgcctcc accggagaca gagtgaccat cacgtgtcgg      480

gcctcccaag ggatctcctc ctacctggcc tggtaccagc agaagcctgg aaaggcaccg      540

aagttgctga tctacgccgc gagcaccctt cagtccggag tgcctagccg cttctcgggt      600

tccggctctg gcactgactt cactctgacc attagctgcc tgcagtccga ggattttgcc      660

acctactact gccagcagta ctatagctac cccctgacct tcgggggcgg aaccaagctc      720

gacatcaag                                                              729


<210>  12
<211>  243
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD123 hScFv binder M12308

<400>  12

Glu Val Gln Leu Val Glu Thr Gly Ala Glu Val Lys Asn Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Leu Ser Asn Tyr 
            20                  25                  30          


Ala Ile Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Gly Ile Ile Pro Ile Phe Gly Thr Ala Asn Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Ile Thr Ala Asp Glu Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Arg Ser Ser Trp Tyr Pro Glu Gly Cys Phe Gln His Trp Gly 
            100                 105                 110         


Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly 
        115                 120                 125             


Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Gln Leu Thr Gln Ser Pro 
    130                 135                 140                 


Ser Ser Leu Ser Ala Ser Thr Gly Asp Arg Val Thr Ile Thr Cys Arg 
145                 150                 155                 160 


Ala Ser Gln Gly Ile Ser Ser Tyr Leu Ala Trp Tyr Gln Gln Lys Pro 
                165                 170                 175     


Gly Lys Ala Pro Lys Leu Leu Ile Tyr Ala Ala Ser Thr Leu Gln Ser 
            180                 185                 190         


Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr 
        195                 200                 205             


Leu Thr Ile Ser Cys Leu Gln Ser Glu Asp Phe Ala Thr Tyr Tyr Cys 
    210                 215                 220                 


Gln Gln Tyr Tyr Ser Tyr Pro Leu Thr Phe Gly Gly Gly Thr Lys Leu 
225                 230                 235                 240 


Asp Ile Lys 
            


<210>  13
<211>  66
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  leader/signal peptide sequence

<400>  13
atgctgctgc tggtgaccag cctgctgctg tgcgaactgc cgcatccggc gtttctgctg       60

attccg                                                                  66


<210>  14
<211>  22
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  leader/signal peptide sequence

<400>  14

Met Leu Leu Leu Val Thr Ser Leu Leu Leu Cys Glu Leu Pro His Pro 
1               5                   10                  15      


Ala Phe Leu Leu Ile Pro 
            20          


<210>  15
<211>  741
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CD123 hScFv binder M12309

<400>  15
gaagtccaat tggtgcagag cggagctgaa gtgaagaaac ctggcgcgac cgtgaagatc       60

tcgtgcaaag tgtccggcta cactttcacc gactactata tgcactgggt gcaacaggcg      120

ccgggaaagg gactggagtg gattggcctt gtggaccccg aagatggcga aaccatctac      180

gccgagaagt tccagggccg ggtcactatc accgcggaca cttccacgga caccgcctac      240

atggaactga gctccctgag atccgaggac accgccgtgt actactgcgc cactgcccca      300

ctgggggaag tcggcgcagc agtggactac tggggacagg gaactctcgt cactgtgtcc      360

agcggtggag gaggcagcgg tggtggaggc tccggtggtg gtggatccca tgtcattctg      420

actcagccgc cgtcagtgtc agccgcccct ggacaagagg tgtccatctc ctgttcgggg      480

tccgatgcca acattgggac caacttggtg tcgtggtacc agcacgtgcc tggaacagcc      540

cccaagctgc tcatctacga gaactcgaag aggccatccg gaattcccgc ccggttttca      600

tcgagccagt cagggacctc cgctaccctg gctatcagcg ggctccagtc tggggatgaa      660

gcgatctact actgcctgac ctgggatcgc accctctccg gaaagatctt cggtggcggc      720

actcagctga ccgtgcttgg a                                                741


<210>  16
<211>  247
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD123 hScFv binder M12309

<400>  16

Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Thr Val Lys Ile Ser Cys Lys Val Ser Gly Tyr Thr Phe Thr Asp Tyr 
            20                  25                  30          


Tyr Met His Trp Val Gln Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Leu Val Asp Pro Glu Asp Gly Glu Thr Ile Tyr Ala Glu Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Ile Thr Ala Asp Thr Ser Thr Asp Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Thr Ala Pro Leu Gly Glu Val Gly Ala Ala Val Asp Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly 
        115                 120                 125             


Gly Gly Ser Gly Gly Gly Gly Ser His Val Ile Leu Thr Gln Pro Pro 
    130                 135                 140                 


Ser Val Ser Ala Ala Pro Gly Gln Glu Val Ser Ile Ser Cys Ser Gly 
145                 150                 155                 160 


Ser Asp Ala Asn Ile Gly Thr Asn Leu Val Ser Trp Tyr Gln His Val 
                165                 170                 175     


Pro Gly Thr Ala Pro Lys Leu Leu Ile Tyr Glu Asn Ser Lys Arg Pro 
            180                 185                 190         


Ser Gly Ile Pro Ala Arg Phe Ser Ser Ser Gln Ser Gly Thr Ser Ala 
        195                 200                 205             


Thr Leu Ala Ile Ser Gly Leu Gln Ser Gly Asp Glu Ala Ile Tyr Tyr 
    210                 215                 220                 


Cys Leu Thr Trp Asp Arg Thr Leu Ser Gly Lys Ile Phe Gly Gly Gly 
225                 230                 235                 240 


Thr Gln Leu Thr Val Leu Gly 
                245         


<210>  17
<211>  744
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CD123 hScFv binder M12310

<400>  17
gaagtgcaac ttgtccaaag cggagccgaa gtgaagaagc caggatcctc cgtgaaagtg       60

tcttgcaaag catccggcgg cactttctcc tcctacgcca tctcctgggt cagacaggcg      120

cctggacagg gtctggagtg gatgggcatt atcaatccta gcggtggctc cacttcgtat      180

gcccagaagt tccagggtcg ggtcaccatg acccgggata cttcaactag caccgtgtac      240

atggaactct cctcgctgcg ctcggacgat accgccgtgt actactgtgc ccgcgagctg      300

ctctggtttg gagagctgga cacctacgga atggacgtct ggggacaggg gaccactgtg      360

acggtgtcgt caggaggcgg aggctcagga gggggtggtt ccggaggggg aggatccctc      420

ccggtgctga cccagccccc aagcgtcagc gtggctccgg gaaagaccgc ccgcatcaca      480

tgcggcggga acaacatcgg ctccaagtcc gtgcattggt accagcagaa gcctggacaa      540

gcgccggtgc tggtcatcta cgacgactca gatcggccct ccggcattcc cgagcggttc      600

agcggctcca actcgggcaa cactgctact ctgaccatct cgagggtgga agcgggggac      660

gaagcagatt actactgcca agtctgggac tccagctccg accacggggt gttcggcgga      720

ggaacccagc tgaccgtgtt ggga                                             744


<210>  18
<211>  248
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD123 hScFv binder M12310

<400>  18

Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Ile Ile Asn Pro Ser Gly Gly Ser Thr Ser Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Met Thr Arg Asp Thr Ser Thr Ser Thr Val Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Glu Leu Leu Trp Phe Gly Glu Leu Asp Thr Tyr Gly Met Asp 
            100                 105                 110         


Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser Gly Gly Gly Gly 
        115                 120                 125             


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Leu Pro Val Leu Thr 
    130                 135                 140                 


Gln Pro Pro Ser Val Ser Val Ala Pro Gly Lys Thr Ala Arg Ile Thr 
145                 150                 155                 160 


Cys Gly Gly Asn Asn Ile Gly Ser Lys Ser Val His Trp Tyr Gln Gln 
                165                 170                 175     


Lys Pro Gly Gln Ala Pro Val Leu Val Ile Tyr Asp Asp Ser Asp Arg 
            180                 185                 190         


Pro Ser Gly Ile Pro Glu Arg Phe Ser Gly Ser Asn Ser Gly Asn Thr 
        195                 200                 205             


Ala Thr Leu Thr Ile Ser Arg Val Glu Ala Gly Asp Glu Ala Asp Tyr 
    210                 215                 220                 


Tyr Cys Gln Val Trp Asp Ser Ser Ser Asp His Gly Val Phe Gly Gly 
225                 230                 235                 240 


Gly Thr Gln Leu Thr Val Leu Gly 
                245             


<210>  19
<211>  732
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CD123 hScFv binder M12311

<400>  19
gaagtgcaac tcgtccaatc tggtgccgaa gtcaagaagc ctggctcaag cgtgaaagtg       60

tcctgcaaag cgtcgggagg gaccttcagc tcctacgcca tttcctgggt ccgccaagca      120

ccaggacagg gcctggagtg gatgggcggc atcatcccga tcttcgggac tgccaactac      180

gcccagaagt tccaggggag agtgaccatt accgccgacg agtcgaccag cacggcctac      240

atggaactgt ccagcctgcg ctccgaggac actgccgtgt actactgcgc gagggccaga      300

ctcggtggag cgttcgacat ctggggacag ggcaccatgg tcaccgtgtc atccggtggc      360

ggaggatccg gtggtggcgg atcaggaggg ggaggatccc agtccgtgct gactcagcct      420

ccctccgtga gcgctgcacc gggacagaag gtcaccatct catgctcggg gggaagctcc      480

aacatcggga accactacgt gtcctggtac caacagttgc ctggtgccgc tccaaagctg      540

ctgatctatg acgataacaa gcggccgtcc ggaatccccg accggttctc ggggtctaga      600

tccggaacca gcgcaactct cggcattacc ggactgcaga gcggcgatga ggccgactac      660

tactgtggca catgggactc gtcgctggct gcccacgtgt ttggcactgg caccaaggtc      720

accgtgcttg ga                                                          732


<210>  20
<211>  244
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD123 hScFv binder M12311

<400>  20

Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Gly Ile Ile Pro Ile Phe Gly Thr Ala Asn Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Ile Thr Ala Asp Glu Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Ala Arg Leu Gly Gly Ala Phe Asp Ile Trp Gly Gln Gly Thr 
            100                 105                 110         


Met Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
        115                 120                 125             


Gly Gly Gly Gly Ser Gln Ser Val Leu Thr Gln Pro Pro Ser Val Ser 
    130                 135                 140                 


Ala Ala Pro Gly Gln Lys Val Thr Ile Ser Cys Ser Gly Gly Ser Ser 
145                 150                 155                 160 


Asn Ile Gly Asn His Tyr Val Ser Trp Tyr Gln Gln Leu Pro Gly Ala 
                165                 170                 175     


Ala Pro Lys Leu Leu Ile Tyr Asp Asp Asn Lys Arg Pro Ser Gly Ile 
            180                 185                 190         


Pro Asp Arg Phe Ser Gly Ser Arg Ser Gly Thr Ser Ala Thr Leu Gly 
        195                 200                 205             


Ile Thr Gly Leu Gln Ser Gly Asp Glu Ala Asp Tyr Tyr Cys Gly Thr 
    210                 215                 220                 


Trp Asp Ser Ser Leu Ala Ala His Val Phe Gly Thr Gly Thr Lys Val 
225                 230                 235                 240 


Thr Val Leu Gly 
                


<210>  21
<211>  747
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CD123 hScFv binder M12313

<400>  21
gaagtgcaac ttgtccagag cggagccgaa gtgaagaaac ctggatcctc cgtcaaagtg       60

tcgtgcaagg cttcgggcgg aaccttctcc tcgtacgcga tctcatgggt cagacaggca      120

cccggacagg gactggagtg gatgggcggc atcattccca tcttcggcac cgctaattac      180

gcccagaagt ttcaggggag agtgaccatc accgccgacg agtccacctc cactgcctac      240

atggaactgt cctcactgag gtccgaggat actgccgtgt actactgcgc gtcgcaaaag      300

gggggtggat ggtccattga cgccttcgat atttggggac aggggacgat ggtcacagtg      360

tcatccggcg gtggtggatc cggtggtggc ggatccggag gaggaggcag ccagtccgtg      420

ctgacccagc cgcctagcgt gtcggccgca tctgggcagc gcgtgaccat ttcctgttcc      480

gggtcctcgt ccaacatcgg caacaactac gcctcctggt accaacagct cccgggaatg      540

gcccctaagc tgctgatcta cgaggacaac aagcggccat ccgggatctc agaccggttc      600

agcggatccc agtccggcac ttccgcgagc ctcgccatca ccggactgca ggctgaggac      660

gaagccgact actactgcca atcatatgac agctcgctca gcggcgatgt ggtgttcggc      720

ggtggcacta agctgaccgt gttggga                                          747


<210>  22
<211>  249
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD123 hScFv binder M12313

<400>  22

Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Gly Ile Ile Pro Ile Phe Gly Thr Ala Asn Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Ile Thr Ala Asp Glu Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ser Gln Lys Gly Gly Gly Trp Ser Ile Asp Ala Phe Asp Ile Trp 
            100                 105                 110         


Gly Gln Gly Thr Met Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly 
        115                 120                 125             


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Ser Val Leu Thr Gln Pro 
    130                 135                 140                 


Pro Ser Val Ser Ala Ala Ser Gly Gln Arg Val Thr Ile Ser Cys Ser 
145                 150                 155                 160 


Gly Ser Ser Ser Asn Ile Gly Asn Asn Tyr Ala Ser Trp Tyr Gln Gln 
                165                 170                 175     


Leu Pro Gly Met Ala Pro Lys Leu Leu Ile Tyr Glu Asp Asn Lys Arg 
            180                 185                 190         


Pro Ser Gly Ile Ser Asp Arg Phe Ser Gly Ser Gln Ser Gly Thr Ser 
        195                 200                 205             


Ala Ser Leu Ala Ile Thr Gly Leu Gln Ala Glu Asp Glu Ala Asp Tyr 
    210                 215                 220                 


Tyr Cys Gln Ser Tyr Asp Ser Ser Leu Ser Gly Asp Val Val Phe Gly 
225                 230                 235                 240 


Gly Gly Thr Lys Leu Thr Val Leu Gly 
                245                 


<210>  23
<211>  729
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CD123 hScFv binder M12314

<400>  23
gaagtccaac tcgtccaaag cggtgcagaa gtgaaaaagc caggctcctc agtgaaagtg       60

tcctgcaaag cctcgggggg aaccttctcc tcctacgcca tctcctgggt ccgccaagca      120

ccaggacagg gcctggagtg gatgggcggg atcattccga tcttcggcac cgccaactac      180

gcccagaagt ttcagggccg cgtgactatc accgccgacg agtccacctc cactgcgtac      240

atggaactgt ccagcctgcg gtccgaggac actgccgtgt attactgcgc gagagtcggt      300

tgctccgggg gatcgtgtta tcccgactac tggggacagg ggaccctcgt gaccgtgtcg      360

tcgggtggtg gtggaagcgg cggtggagga tccggtggag gaggcagcga aatcgtgctg      420

actcagtcgc cgtcctcgct ttccgcctcc gtgggagatc gcgtgaccat cacgtgtcag      480

gcttctcaag acattagcaa ctacctgaat tggtaccagc agaagcctgg aaaggctccg      540

aagctgctca tctacgacgc gtccaacctg gagacagggg tgccttcacg gttctcggga      600

agcggatccg gcaccgattt caccttcacc atttcaagcc tgcaacccga ggatattgcc      660

acctactact gccagcagta cgacaacctc cccctgactt tcgggggcgg cactaagttg      720

gacatcaag                                                              729


<210>  24
<211>  243
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD123 hScFv binder M12314

<400>  24

Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Gly Ile Ile Pro Ile Phe Gly Thr Ala Asn Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Ile Thr Ala Asp Glu Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Val Gly Cys Ser Gly Gly Ser Cys Tyr Pro Asp Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly 
        115                 120                 125             


Gly Gly Ser Gly Gly Gly Gly Ser Glu Ile Val Leu Thr Gln Ser Pro 
    130                 135                 140                 


Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Gln 
145                 150                 155                 160 


Ala Ser Gln Asp Ile Ser Asn Tyr Leu Asn Trp Tyr Gln Gln Lys Pro 
                165                 170                 175     


Gly Lys Ala Pro Lys Leu Leu Ile Tyr Asp Ala Ser Asn Leu Glu Thr 
            180                 185                 190         


Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr 
        195                 200                 205             


Phe Thr Ile Ser Ser Leu Gln Pro Glu Asp Ile Ala Thr Tyr Tyr Cys 
    210                 215                 220                 


Gln Gln Tyr Asp Asn Leu Pro Leu Thr Phe Gly Gly Gly Thr Lys Leu 
225                 230                 235                 240 


Asp Ile Lys 
            


<210>  25
<211>  735
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CD123 hScFv binder M12315

<400>  25
caagtccagt tgcaacaatg gggagcaggc cttctgaaac cgtccgagac actgagcctg       60

acgtgcgccg tctatggcgg atcgttctcc ggatactact ggtcgtggat cagacagcct      120

ccgggaaagg gtctggaatg gatcggcgaa atcaaccaca gcggcagcac caattacaac      180

ccgtcactga agtcaagggt caccattagc gtggacactt ccaagaacca gttctccctg      240

aaactgtcga gcgtgaccgc tgccgatact gccgtgtact actgtgcccg cggccaagtc      300

aagtatagct caagcctcgg ctactggggc cagggaaccc tcgtgaccgt gtcctcgggt      360

ggaggaggct ccggtggtgg aggatccggt ggcggaggat cgcagtccgt gctgacccag      420

cctccctccg tgtctgctgc ccctgggcaa aaggtcacca tttcgtgctc cggctcatcg      480

tccaacatcg ggaacaactt tgtgtcctgg taccagcagc tgcccggtac tgccccaaag      540

ctgctgatct acgaggacaa caagcgccca tccgggattc cggatcggtt cagcggatca      600

cggtccggaa ctagcgcgac cctggggatc accgggctcc agactggcga cgaagcggac      660

tactactgcg gaacttggga ctcctccttg ggggcctggg tgttcggcgg agggaccaag      720

ctcaccgtgc ttgga                                                       735


<210>  26
<211>  245
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD123 hScFv binder M12315

<400>  26

Gln Val Gln Leu Gln Gln Trp Gly Ala Gly Leu Leu Lys Pro Ser Glu 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Ala Val Tyr Gly Gly Ser Phe Ser Gly Tyr 
            20                  25                  30          


Tyr Trp Ser Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Glu Ile Asn His Ser Gly Ser Thr Asn Tyr Asn Pro Ser Leu Lys 
    50                  55                  60                  


Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe Ser Leu 
65                  70                  75                  80  


Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Gly Gln Val Lys Tyr Ser Ser Ser Leu Gly Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
        115                 120                 125             


Ser Gly Gly Gly Gly Ser Gln Ser Val Leu Thr Gln Pro Pro Ser Val 
    130                 135                 140                 


Ser Ala Ala Pro Gly Gln Lys Val Thr Ile Ser Cys Ser Gly Ser Ser 
145                 150                 155                 160 


Ser Asn Ile Gly Asn Asn Phe Val Ser Trp Tyr Gln Gln Leu Pro Gly 
                165                 170                 175     


Thr Ala Pro Lys Leu Leu Ile Tyr Glu Asp Asn Lys Arg Pro Ser Gly 
            180                 185                 190         


Ile Pro Asp Arg Phe Ser Gly Ser Arg Ser Gly Thr Ser Ala Thr Leu 
        195                 200                 205             


Gly Ile Thr Gly Leu Gln Thr Gly Asp Glu Ala Asp Tyr Tyr Cys Gly 
    210                 215                 220                 


Thr Trp Asp Ser Ser Leu Gly Ala Trp Val Phe Gly Gly Gly Thr Lys 
225                 230                 235                 240 


Leu Thr Val Leu Gly 
                245 


<210>  27
<211>  72
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CD8 transmembrane domain

<400>  27
atctacatct gggcgccctt ggccgggact tgtggggtcc ttctcctgtc actggttatc       60

accctttact gc                                                           72


<210>  28
<211>  22
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD8 transmembrane domain

<400>  28

Ile Trp Ala Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu Ser Leu 
1               5                   10                  15      


Val Ile Thr Leu Tyr Cys 
            20          


<210>  29
<211>  135
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CD8 hinge domain

<400>  29
accacgacgc cagcgccgcg accaccaaca ccggcgccca ccatcgcgtc gcagcccctg       60

tccctgcgcc cagaggcgtg ccggccagcg gcggggggcg cagtgcacac gagggggctg      120

gacttcgcct gtgat                                                       135


<210>  30
<211>  47
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD8 hinge domain

<400>  30

Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala 
1               5                   10                  15      


Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly 
            20                  25                  30          


Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp Ile Tyr 
        35                  40                  45          


<210>  31
<211>  42
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  amino acid sequence of amino acid numbers 118 to 178 hinge region
       of CD8.alpha

<400>  31

Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met 
1               5                   10                  15      


Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe 
            20                  25                  30          


Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu 
        35                  40          


<210>  32
<211>  106
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human IgG CL sequence

<400>  32

Gly Gln Pro Lys Ala Ala Pro Ser Val Thr Leu Phe Pro Pro Ser Ser 
1               5                   10                  15      


Glu Glu Leu Gln Ala Asn Lys Ala Thr Leu Val Cys Leu Ile Ser Asp 
            20                  25                  30          


Phe Tyr Pro Gly Ala Val Thr Val Ala Trp Lys Ala Asp Ser Ser Pro 
        35                  40                  45              


Val Lys Ala Gly Val Glu Thr Thr Thr Pro Ser Lys Gln Ser Asn Asn 
    50                  55                  60                  


Lys Tyr Ala Ala Ser Ser Tyr Leu Ser Leu Thr Pro Glu Gln Trp Lys 
65                  70                  75                  80  


Ser His Arg Ser Tyr Ser Cys Gln Val Thr His Glu Gly Ser Thr Val 
                85                  90                  95      


Glu Lys Thr Val Ala Pro Thr Glu Cys Ser 
            100                 105     


<210>  33
<211>  126
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  signaling domain of 4-1BB

<400>  33
aaacggggca gaaagaaact cctgtatata ttcaaacaac catttatgag accagtacaa       60

actactcaag aggaagatgg ctgtagctgc cgatttccag aagaagaaga aggaggatgt      120

gaactg                                                                 126


<210>  34
<211>  42
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  signaling domain of 4-1BB

<400>  34

Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met 
1               5                   10                  15      


Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe 
            20                  25                  30          


Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu 
        35                  40          


<210>  35
<211>  336
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  signaling domain of CD3-zeta

<400>  35
agagtgaagt tcagcaggag cgcagacgcc cccgcgtaca agcagggcca gaaccagctc       60

tataacgagc tcaatctagg acgaagagag gagtacgatg ttttggacaa gagacgtggc      120

cgggaccctg agatgggggg aaagccgaga aggaagaacc ctcaggaagg cctgtacaat      180

gaactgcaga aagataagat ggcggaggcc tacagtgaga ttgggatgaa aggcgagcgc      240

cggaggggca aggggcacga tggcctttac cagggtctca gtacagccac caaggacacc      300

tacgacgccc ttcacatgca ggccctgccc cctcgc                                336


<210>  36
<211>  112
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD3zeta

<400>  36

Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Lys Gln Gly 
1               5                   10                  15      


Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr 
            20                  25                  30          


Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys 
        35                  40                  45              


Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys 
    50                  55                  60                  


Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg 
65                  70                  75                  80  


Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala 
                85                  90                  95      


Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
            100                 105                 110         


<210>  37
<211>  726
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  ScFv CD 19

<400>  37
gacatccaga tgacacagac tacatcctcc ctgtctgcct ctctgggaga cagagtcacc       60

atcagttgca gggcaagtca ggacattagt aaatatttaa attggtatca gcagaaacca      120

gatggaactg ttaaactcct gatctaccat acatcaagat tacactcagg agtcccatca      180

aggttcagtg gcagtgggtc tggaacagat tattctctca ccattagcaa cctggagcaa      240

gaagatattg ccacttactt ttgccaacag ggtaatacgc ttccgtacac gttcggaggg      300

gggaccaagc tggagatcac aggtggcggt ggctcgggcg gtggtgggtc gggtggcggc      360

ggatctgagg tgaaactgca ggagtcagga cctggcctgg tggcgccctc acagagcctg      420

tccgtcacat gcactgtctc aggggtctca ttacccgact atggtgtaag ctggattcgc      480

cagcctccac gaaagggtct ggagtggctg ggagtaatat ggggtagtga aaccacatac      540

tataattcag ctctcaaatc cagactgacc atcatcaagg acaactccaa gagccaagtt      600

ttcttaaaaa tgaacagtct gcaaactgat gacacagcca tttactactg tgccaaacat      660

tattactacg gtggtagcta tgctatggac tactggggcc aaggaacctc agtcaccgtc      720

tcctca                                                                 726


<210>  38
<211>  242
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ScFv CD 19

<400>  38

Asp Ile Gln Met Thr Gln Thr Thr Ser Ser Leu Ser Ala Ser Leu Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Ser Cys Arg Ala Ser Gln Asp Ile Ser Lys Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Asp Gly Thr Val Lys Leu Leu Ile 
        35                  40                  45              


Tyr His Thr Ser Arg Leu His Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Tyr Ser Leu Thr Ile Ser Asn Leu Glu Gln 
65                  70                  75                  80  


Glu Asp Ile Ala Thr Tyr Phe Cys Gln Gln Gly Asn Thr Leu Pro Tyr 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Thr Gly Gly Gly Gly Ser 
            100                 105                 110         


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val Lys Leu Gln Glu 
        115                 120                 125             


Ser Gly Pro Gly Leu Val Ala Pro Ser Gln Ser Leu Ser Val Thr Cys 
    130                 135                 140                 


Thr Val Ser Gly Val Ser Leu Pro Asp Tyr Gly Val Ser Trp Ile Arg 
145                 150                 155                 160 


Gln Pro Pro Arg Lys Gly Leu Glu Trp Leu Gly Val Ile Trp Gly Ser 
                165                 170                 175     


Glu Thr Thr Tyr Tyr Asn Ser Ala Leu Lys Ser Arg Leu Thr Ile Ile 
            180                 185                 190         


Lys Asp Asn Ser Lys Ser Gln Val Phe Leu Lys Met Asn Ser Leu Gln 
        195                 200                 205             


Thr Asp Asp Thr Ala Ile Tyr Tyr Cys Ala Lys His Tyr Tyr Tyr Gly 
    210                 215                 220                 


Gly Ser Tyr Ala Met Asp Tyr Trp Gly Gln Gly Thr Ser Val Thr Val 
225                 230                 235                 240 


Ser Ser 
        


<210>  39
<211>  66
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  GMCSF leader peptide

<400>  39
atgctgctgc tggtgaccag cctgctgctg tgcgaactgc cgcatccggc gtttctgctg       60

attccg                                                                  66


<210>  40
<211>  22
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GMCSF leader peptide

<400>  40

Met Leu Leu Leu Val Thr Ser Leu Leu Leu Cys Glu Leu Pro His Pro 
1               5                   10                  15      


Ala Phe Leu Leu Ile Pro 
            20          


<210>  41
<211>  85
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  TNFRSF19 leader peptide

<400>  41
ggctctgaaa gtgctgttgg aacaagaaaa gaccttcttc accttgctcg tgttgctggg       60

gtacctgtcc tgcaaagtca cctgt                                             85


<210>  42
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TNFRSF19 leader peptide

<400>  42

Met Ala Leu Lys Val Leu Leu Glu Gln Glu Lys Thr Phe Phe Thr Leu 
1               5                   10                  15      


Leu Val Leu Leu Gly Tyr Leu Ser Cys Lys Val Thr Cys 
            20                  25                  


<210>  43
<211>  63
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CD8 alpha leader peptide

<400>  43
atggcgctgc cggtgaccgc gctgctgctg ccgctggcgc tgctgctgca tgcggcgcgc       60

ccg                                                                     63


<210>  44
<211>  21
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD8 alpha leader peptide

<400>  44

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro 
            20      


<210>  45
<211>  123
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CD28 co-stimulatory domain

<400>  45
cggtcgaaga ggtccagact cttgcactcc gactacatga acatgactcc tagaaggccc       60

ggacccacta gaaagcacta ccagccgtac gcccctcctc gggatttcgc cgcataccgg      120

tcc                                                                    123


<210>  46
<211>  41
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD28 co-stimulatory domain

<400>  46

Arg Ser Lys Arg Ser Arg Leu Leu His Ser Asp Tyr Met Asn Met Thr 
1               5                   10                  15      


Pro Arg Arg Pro Gly Pro Thr Arg Lys His Tyr Gln Pro Tyr Ala Pro 
            20                  25                  30          


Pro Arg Asp Phe Ala Ala Tyr Arg Ser 
        35                  40      


<210>  47
<211>  336
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CD3 zeta activation domain

<400>  47
agagtgaagt tcagccgctc agccgatgca ccggcctacc agcagggaca gaaccagctc       60

tacaacgagc tcaacctggg tcggcgggaa gaatatgacg tgctggacaa acggcgcggc      120

agagatccgg agatgggggg aaagccgagg aggaagaacc ctcaagaggg cctgtacaac      180

gaactgcaga aggacaagat ggcggaagcc tactccgaga tcggcatgaa gggagaacgc      240

cggagaggga agggtcatga cggactgtac cagggcctgt caactgccac taaggacact      300

tacgatgcgc tccatatgca agctttgccc ccgcgg                                336


<210>  48
<211>  112
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD3 zeta activation domain

<400>  48

Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly 
1               5                   10                  15      


Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr 
            20                  25                  30          


Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys 
        35                  40                  45              


Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys 
    50                  55                  60                  


Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg 
65                  70                  75                  80  


Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala 
                85                  90                  95      


Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
            100                 105                 110         


<210>  49
<211>  201
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  TNFRSF19 hinge and transmembrane domain

<400>  49
gcggccgcgg tcggattcca agacatggaa tgcgtgccct gcggcgaccc gccacctcct       60

tacgagccgc actgcgcatc gaaggtcaac ctcgtgaaga tcgcgagcac cgcgtcctca      120

ccccgggata ctgctctggc cgccgtgatt tgttccgcct tggccaccgt gcttctggcc      180

ctgctgatcc tctgtgtgat c                                                201


<210>  50
<211>  67
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TNFRSF19 hinge and transmembrane domain

<400>  50

Ala Ala Ala Val Gly Phe Gln Asp Met Glu Cys Val Pro Cys Gly Asp 
1               5                   10                  15      


Pro Pro Pro Pro Tyr Glu Pro His Cys Ala Ser Lys Val Asn Leu Val 
            20                  25                  30          


Lys Ile Ala Ser Thr Ala Ser Ser Pro Arg Asp Thr Ala Leu Ala Ala 
        35                  40                  45              


Val Ile Cys Ser Ala Leu Ala Thr Val Leu Leu Ala Leu Leu Ile Leu 
    50                  55                  60                  


Cys Val Ile 
65          


<210>  51
<211>  63
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  TNFRSF19 transmembrane domain

<400>  51
gccgccgtga tttgttccgc cttggccacc gtgcttctgg ccctgctgat cctctgtgtg       60

atc                                                                     63


<210>  52
<211>  21
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TNFRSF19 transmembrane domain

<400>  52

Ala Ala Val Ile Cys Ser Ala Leu Ala Thr Val Leu Leu Ala Leu Leu 
1               5                   10                  15      


Ile Leu Cys Val Ile 
            20      


<210>  53
<211>  138
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  TNFRSF19 hinge domain

<400>  53
gcggccgcgg tcggattcca agacatggaa tgcgtgccct gcggcgaccc gccacctcct       60

tacgagccgc actgcgcatc gaaggtcaac ctcgtgaaga tcgcgagcac cgcgtcctca      120

ccccgggata ctgctctg                                                    138


<210>  54
<211>  46
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TNFRSF19 hinge domain

<400>  54

Ala Ala Ala Val Gly Phe Gln Asp Met Glu Cys Val Pro Cys Gly Asp 
1               5                   10                  15      


Pro Pro Pro Pro Tyr Glu Pro His Cys Ala Ser Lys Val Asn Leu Val 
            20                  25                  30          


Lys Ile Ala Ser Thr Ala Ser Ser Pro Arg Asp Thr Ala Leu 
        35                  40                  45      


<210>  55
<211>  80
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  truncated TNFRSF19 hinge domain

<400>  55
tacgagcctc actgcgccag caaagtcaac ttggtgaaga tcgcgagcac tgcctcgtcc       60

cctcgggaca ctgctctggc                                                   80


<210>  56
<211>  26
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  truncated TNFRSF19 hinge domain

<400>  56

Tyr Glu Pro His Cys Ala Ser Lys Val Asn Leu Val Lys Ile Ala Ser 
1               5                   10                  15      


Thr Ala Ser Ser Pro Arg Asp Thr Ala Leu 
            20                  25      


<210>  57
<211>  222
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CD8a hinge domain fused to TNFRSF19 transmembrane domain

<400>  57
gcggccgcgc ccgcccctcg gcccccgact cctgccccga cgatcgcttc ccaacctctc       60

tcgctgcgcc cggaagcatg ccggcccgcc gccggtggcg ctgtccacac tcgcggactg      120

gactttgata ccgcactggc ggccgtgatc tgtagcgccc tggccaccgt gctgctggcg      180

ctgctcatcc tttgcgtgat ctactgcaag cggcagccta gg                         222


<210>  58
<211>  74
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD8a hinge domain fused to TNFRSF19 transmembrane domain

<400>  58

Ala Ala Ala Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala 
1               5                   10                  15      


Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly 
            20                  25                  30          


Gly Ala Val His Thr Arg Gly Leu Asp Phe Asp Thr Ala Leu Ala Ala 
        35                  40                  45              


Val Ile Cys Ser Ala Leu Ala Thr Val Leu Leu Ala Leu Leu Ile Leu 
    50                  55                  60                  


Cys Val Ile Tyr Cys Lys Arg Gln Pro Arg 
65                  70                  


<210>  59
<211>  123
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CD28 co-stimulatory domain

<400>  59
cggtcgaaga ggtccagact cttgcactcc gactacatga acatgactcc tagaaggccc       60

ggacccacta gaaagcacta ccagccgtac gcccctcctc gggatttcgc cgcataccgg      120

tcc                                                                    123


<210>  60
<211>  41
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD28 co-stimulatory domain

<400>  60

Arg Ser Lys Arg Ser Arg Leu Leu His Ser Asp Tyr Met Asn Met Thr 
1               5                   10                  15      


Pro Arg Arg Pro Gly Pro Thr Arg Lys His Tyr Gln Pro Tyr Ala Pro 
            20                  25                  30          


Pro Arg Asp Phe Ala Ala Tyr Arg Ser 
        35                  40      


<210>  61
<211>  336
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CD3 zeta version 2

<400>  61
cgcgtgaaat ttagccgcag cgcggatgcg ccggcgtatc agcagggcca gaaccagctg       60

tataacgaac tgaacctggg ccgccgcgaa gaatatgatg tgctggataa acgccgcggc      120

cgcgatccgg aaatgggcgg caaaccgcgc cgcaaaaacc cgcaggaagg cctgtataac      180

gaactgcaga aagataaaat ggcggaagcg tatagcgaaa ttggcatgaa aggcgaacgc      240

cgccgcggca aaggccatga tggcctgtat cagggcctga gcaccgcgac caaagatacc      300

tatgatgcgc tgcatatgca ggcgctgccg ccgcgc                                336


<210>  62
<211>  112
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD3 zeta version 2

<400>  62

Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly 
1               5                   10                  15      


Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr 
            20                  25                  30          


Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys 
        35                  40                  45              


Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys 
    50                  55                  60                  


Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg 
65                  70                  75                  80  


Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala 
                85                  90                  95      


Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
            100                 105                 110         


<210>  63
<211>  93
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Furin P2A Furin

<400>  63
cgcgcgaaac gcagcggcag cggcgcgacc aactttagcc tgctgaaaca ggcgggcgat       60

gtggaagaaa acccgggccc gcgagcaaag agg                                    93


<210>  64
<211>  31
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Furin P2A Furin

<400>  64

Arg Ala Lys Arg Ser Gly Ser Gly Ala Thr Asn Phe Ser Leu Leu Lys 
1               5                   10                  15      


Gln Ala Gly Asp Val Glu Glu Asn Pro Gly Pro Arg Ala Lys Arg 
            20                  25                  30      


<210>  65
<211>  78
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Furin T2A

<400>  65
agagctaaac gctctgggtc tggtgaagga cgaggtagcc ttcttacgtg cggagacgtg       60

gaggaaaacc caggaccc                                                     78


<210>  66
<211>  26
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Furin T2A

<400>  66

Arg Ala Lys Arg Ser Gly Ser Gly Glu Gly Arg Gly Ser Leu Leu Thr 
1               5                   10                  15      


Cys Gly Asp Val Glu Glu Asn Pro Gly Pro 
            20                  25      


<210>  67
<211>  1005
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  truncated EGFR (tEGFR) tag

<400>  67
aggaaggttt gcaatggaat cggtataggg gagtttaagg attcacttag cataaacgct       60

actaatatta aacacttcaa aaactgtacg agtataagtg gagatcttca cattttgccg      120

gttgcattcc gaggcgattc attcacccac acgccaccgc ttgacccaca agaattggat      180

attcttaaaa ccgttaaaga aataacgggg tttttgctca ttcaagcgtg gccagaaaat      240

cgcactgacc tccatgcttt cgagaacctg gagattataa gaggacgaac taagcagcat      300

ggtcaattct cccttgctgt ggtcagcctg aacatcacca gtcttggttt gcggtccctc      360

aaggaaattt cagatggaga tgtcatcata agcggcaaca agaatttgtg ctatgcaaat      420

accataaact ggaaaaaact gtttggcact tccggccaga aaaccaagat tatttcaaat      480

cggggtgaga acagctgcaa agccaccggc caggtttgtc atgccttgtg ctctccggaa      540

ggctgttggg ggccagaacc cagggactgc gtcagttgca gaaacgtctc aagaggccgc      600

gaatgcgttg acaagtgtaa cctccttgag ggtgagccac gagagtttgt tgagaacagc      660

gagtgtatac aatgtcaccc tgaatgtttg ccccaggcta tgaatataac ctgcacaggc      720

cgcgggcctg ataactgcat ccagtgtgct cattacatag atggacctca ctgtgtgaaa      780

acctgcccgg ccggagttat gggagaaaac aacactctgg tgtggaaata cgctgatgca      840

ggccacgtgt gccacctttg tcacccgaat tgtacatatg ggtgtaccgg tcctggactt      900

gaaggttgcc ctaccaatgg ccctaaaata cccagtatcg caactggcat ggtaggcgct      960

cttctcttgc tcttggtagt tgctctcggc ataggtcttt ttatg                     1005


<210>  68
<211>  335
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  truncated EGFR (tEGFR) tag

<400>  68

Arg Lys Val Cys Asn Gly Ile Gly Ile Gly Glu Phe Lys Asp Ser Leu 
1               5                   10                  15      


Ser Ile Asn Ala Thr Asn Ile Lys His Phe Lys Asn Cys Thr Ser Ile 
            20                  25                  30          


Ser Gly Asp Leu His Ile Leu Pro Val Ala Phe Arg Gly Asp Ser Phe 
        35                  40                  45              


Thr His Thr Pro Pro Leu Asp Pro Gln Glu Leu Asp Ile Leu Lys Thr 
    50                  55                  60                  


Val Lys Glu Ile Thr Gly Phe Leu Leu Ile Gln Ala Trp Pro Glu Asn 
65                  70                  75                  80  


Arg Thr Asp Leu His Ala Phe Glu Asn Leu Glu Ile Ile Arg Gly Arg 
                85                  90                  95      


Thr Lys Gln His Gly Gln Phe Ser Leu Ala Val Val Ser Leu Asn Ile 
            100                 105                 110         


Thr Ser Leu Gly Leu Arg Ser Leu Lys Glu Ile Ser Asp Gly Asp Val 
        115                 120                 125             


Ile Ile Ser Gly Asn Lys Asn Leu Cys Tyr Ala Asn Thr Ile Asn Trp 
    130                 135                 140                 


Lys Lys Leu Phe Gly Thr Ser Gly Gln Lys Thr Lys Ile Ile Ser Asn 
145                 150                 155                 160 


Arg Gly Glu Asn Ser Cys Lys Ala Thr Gly Gln Val Cys His Ala Leu 
                165                 170                 175     


Cys Ser Pro Glu Gly Cys Trp Gly Pro Glu Pro Arg Asp Cys Val Ser 
            180                 185                 190         


Cys Arg Asn Val Ser Arg Gly Arg Glu Cys Val Asp Lys Cys Asn Leu 
        195                 200                 205             


Leu Glu Gly Glu Pro Arg Glu Phe Val Glu Asn Ser Glu Cys Ile Gln 
    210                 215                 220                 


Cys His Pro Glu Cys Leu Pro Gln Ala Met Asn Ile Thr Cys Thr Gly 
225                 230                 235                 240 


Arg Gly Pro Asp Asn Cys Ile Gln Cys Ala His Tyr Ile Asp Gly Pro 
                245                 250                 255     


His Cys Val Lys Thr Cys Pro Ala Gly Val Met Gly Glu Asn Asn Thr 
            260                 265                 270         


Leu Val Trp Lys Tyr Ala Asp Ala Gly His Val Cys His Leu Cys His 
        275                 280                 285             


Pro Asn Cys Thr Tyr Gly Cys Thr Gly Pro Gly Leu Glu Gly Cys Pro 
    290                 295                 300                 


Thr Asn Gly Pro Lys Ile Pro Ser Ile Ala Thr Gly Met Val Gly Ala 
305                 310                 315                 320 


Leu Leu Leu Leu Leu Val Val Ala Leu Gly Ile Gly Leu Phe Met 
                325                 330                 335 


<210>  69
<211>  717
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CD123 hScFv binder M12316

<400>  69
gaagtgcagt tggtggagag cggtggagga cttgtgcaac ctggtggatc cctgagattg       60

tcgtgcgcag cttcagggtt caccttctcc tcctacgcca tgcactgggt ccgccaagca      120

ccaggaaagg gcctggaatg ggtcagctcc atctcctcgt cgtcctcgta catctactat      180

gccgactccg tgaagggccg cttcaccatt agccgggaca actcaaagaa cactctgtac      240

cttcaaatga actccctgcg ggctgaagat accgccgtgt actactgcgc gagggattgg      300

gatgacgcgt tcgacatttg gggccagggg actaccgtca ccgtgtcgtc gggtggagga      360

ggatccgggg gtggaggatc gggagggggt ggaagcgaca ttcagatgac tcagagcccg      420

tcctccctgt cggcctcagt gggcgacaga gtgaccatca cctgtcaagc cagccaggac      480

atctcaaact acctgaactg gtaccagcag aagcccggaa aggcccctaa gctgctcatc      540

tacgacgcct ccaacctgga gactggagtg ccctcacggt tttccggctc tggaagcggc      600

accgatttca ccttcacgat ctcctccctg caaccggaag atatcgcgac ctactactgc      660

cagcagtatg acaatctccc gctcaccttc ggtggcggca ctaagctcga gatcaaa         717


<210>  70
<211>  239
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD123 hScFv binder M12316

<400>  70

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ser Ile Ser Ser Ser Ser Ser Tyr Ile Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Trp Asp Asp Ala Phe Asp Ile Trp Gly Gln Gly Thr Thr 
            100                 105                 110         


Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
        115                 120                 125             


Gly Gly Gly Ser Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser 
    130                 135                 140                 


Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Gln Ala Ser Gln Asp 
145                 150                 155                 160 


Ile Ser Asn Tyr Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro 
                165                 170                 175     


Lys Leu Leu Ile Tyr Asp Ala Ser Asn Leu Glu Thr Gly Val Pro Ser 
            180                 185                 190         


Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Phe Thr Ile Ser 
        195                 200                 205             


Ser Leu Gln Pro Glu Asp Ile Ala Thr Tyr Tyr Cys Gln Gln Tyr Asp 
    210                 215                 220                 


Asn Leu Pro Leu Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
225                 230                 235                 


<210>  71
<211>  723
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CD123 hScFv binder M12317

<400>  71
caagtccaac tcgtcgaaac tggtggtggc ctcgtgaagc ctggaggatc cctgcgcctt       60

tcctgtgccg cttccggctt tactttctcg tcgtactcca tgaactgggt cagacaggct      120

cccggaaagg gcctggaatg ggtgtcctcc atctcgtcct catcctccta catctattac      180

gcggactccg tgaagggcag attcaccatt tcccgggaca acgccaagaa cagcttgtac      240

ctccaaatga actccctgcg ggcagaggac accgccgtgt actactgcgc gagggatggg      300

gatttctgga gcggagccat cgactactgg ggccagggaa ctctcgtgac cgtcagctcc      360

ggtggtggtg gaagcggagg cggaggttct ggggggggag gatcagacat tcagctgacc      420

cagtcgccat cctccctgag cgcctcagtg ggggaccgcg tgactattac atgccaggcc      480

tcccaagata tctcgaacta cctgaactgg tatcagcaga agcctggaaa ggccccgaag      540

ctgttgatct acgatgccag caacctggag actggggtgc cttcccggtt ctcgggatca      600

ggctcgggca ccgatttcac cttcacgatc agcagcctgc agcccgagga cattgcaacc      660

tactactgcc agcagtacga caatctgccg ctttttgggg gaggcaccaa gctggaaatc      720

aaa                                                                    723


<210>  72
<211>  241
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD123 hScFv binder M12317

<400>  72

Gln Val Gln Leu Val Glu Thr Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ser Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ser Ile Ser Ser Ser Ser Ser Tyr Ile Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Gly Asp Phe Trp Ser Gly Ala Ile Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly 
        115                 120                 125             


Gly Ser Gly Gly Gly Gly Ser Asp Ile Gln Leu Thr Gln Ser Pro Ser 
    130                 135                 140                 


Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Gln Ala 
145                 150                 155                 160 


Ser Gln Asp Ile Ser Asn Tyr Leu Asn Trp Tyr Gln Gln Lys Pro Gly 
                165                 170                 175     


Lys Ala Pro Lys Leu Leu Ile Tyr Asp Ala Ser Asn Leu Glu Thr Gly 
            180                 185                 190         


Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Phe 
        195                 200                 205             


Thr Ile Ser Ser Leu Gln Pro Glu Asp Ile Ala Thr Tyr Tyr Cys Gln 
    210                 215                 220                 


Gln Tyr Asp Asn Leu Pro Leu Phe Gly Gly Gly Thr Lys Leu Glu Ile 
225                 230                 235                 240 


Lys 
    


<210>  73
<211>  723
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CD123 hScFv binder  M12318

<400>  73
gaggtgcaat tggtgcagtc aggtggtgga gtggtgcagc caggaagatc ccttagactc       60

tcgtgtgcgg cgtcaggctt taccttctcc tcgtactcca tgaactgggt cagacaggca      120

ccgggaaagg gactggaatg ggtgtcctcc atctcgtcct cctcctccta catctactac      180

gccgatagcg tgaagggccg gttcaccatt tcgcgcgaca acgccaagaa caccctgtac      240

ctccaaatga attcgctgcg ggccgaagat accgctgtct attactgcgc ccgcgacaac      300

tggggctcgc tggactattg gggccaggga accctcgtca ccgtgtcaag cggagggggt      360

ggatccggag gcggaggatc cggtggaggg ggaagcgaca ttcagatgac tcagagcccg      420

tcctccctgt ctgcctccgt gggggatcgc gtgaccatca catgccaggc ctcacaagac      480

atcagcaatt acctgaactg gtaccagcag aagcctggaa aggcccccaa gctgctgatc      540

tacgatgcca gcaacctgga gactggggtg ccttcaaggt tctccggttc cggaagcggc      600

actgacttca ccttcactat ctcgagcctg caacccgagg acattgccac ctactactgc      660

cagcagtacg acaaccttcc gcacatgtac acgttcggcc agggcaccaa gctcgaaatc      720

aaa                                                                    723


<210>  74
<211>  241
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD123 hScFv binder M12318

<400>  74

Glu Val Gln Leu Val Gln Ser Gly Gly Gly Val Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ser Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ser Ile Ser Ser Ser Ser Ser Tyr Ile Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Asn Trp Gly Ser Leu Asp Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         


Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
        115                 120                 125             


Gly Gly Gly Ser Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser 
    130                 135                 140                 


Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Gln Ala Ser Gln Asp 
145                 150                 155                 160 


Ile Ser Asn Tyr Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro 
                165                 170                 175     


Lys Leu Leu Ile Tyr Asp Ala Ser Asn Leu Glu Thr Gly Val Pro Ser 
            180                 185                 190         


Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Phe Thr Ile Ser 
        195                 200                 205             


Ser Leu Gln Pro Glu Asp Ile Ala Thr Tyr Tyr Cys Gln Gln Tyr Asp 
    210                 215                 220                 


Asn Leu Pro His Met Tyr Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile 
225                 230                 235                 240 


Lys 
    


<210>  75
<211>  1473
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  LTG 2074 (hScFv aCD123 CD8 TM 4-1BB CD3 zeta)

<400>  75
atgctgctgc tggtgaccag cctgctgctg tgcgaactgc cgcatccggc gtttctgctg       60

attccggaag tgcaactcgt ccaaagcgga gctgaagtga agaaaccagg cggatccctg      120

agactgtctt gcgccgcatc gggcttcacc ttctcctcgt attccatgaa ctgggtcaga      180

caggcccctg gaaagggtct ggaatgggtg tcctccattt cctcctcgtc gagctacatc      240

tactacgccg actccgtgaa ggggcgcttc acaatctccc gggacaacgc gaagaactcc      300

ctgtacctcc aaatgaactc cctgagggcc gaggatactg ccgtgtacta ctgcgccatc      360

gagagctggg gctccctcga ctattggggc cagggaaccc tggtcaccgt gtcatccggc      420

ggtggaggat cgggtggtgg cggatccgga ggagggggat cccagagcgt gctgacccaa      480

cccccgtcag tgtcagccgc gcctggacag aaggtcacca tcagctgtag cggctcatcc      540

tccaatatcg gcgacgatta cgtgtcctgg taccagcagc ttcctggaac cgctcccaag      600

ctcctgatct acgacaacca caagcgcccg tcgggaattc cggaccggtt tagcggttca      660

aagtccggga ctagcgcgac tctggggatt accggactgc agacgggcga cgaagccgat      720

tactactgcg ggacttggga tgactcgctt agcggagtgg tgttcggtgg cgggaccaag      780

ctcactgtgt tgggagcggc cgcaactacc acccctgccc ctcggccgcc gactccggcc      840

ccaaccatcg caagccaacc cctctccttg cgccccgaag cttgccgccc ggccgcgggt      900

ggagccgtgc atacccgggg gctggacttt gcctgcgata tctacatttg ggccccgctg      960

gccggcactt gcggcgtgct cctgctgtcg ctggtcatca ccctttactg caagaggggc     1020

cggaagaagc tgctttacat cttcaagcag ccgttcatgc ggcccgtgca gacgactcag     1080

gaagaggacg gatgctcgtg cagattccct gaggaggaag aggggggatg cgaactgcgc     1140

gtcaagttct cacggtccgc cgacgccccc gcatatcaac agggccagaa tcagctctac     1200

aacgagctga acctgggaag gagagaggag tacgacgtgc tggacaagcg acgcggacgc     1260

gacccggaga tgggggggaa accacggcgg aaaaaccctc aggaaggact gtacaacgaa     1320

ctccagaaag acaagatggc ggaagcctac tcagaaatcg ggatgaaggg agagcggagg     1380

aggggaaagg gtcacgacgg gctgtaccag ggactgagca ccgccactaa ggatacctac     1440

gatgccttgc atatgcaagc actcccaccc cgg                                  1473


<210>  76
<211>  491
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LTG 2074 (hScFv aCD123 CD8 TM 4-1BB CD3 zeta)

<400>  76

Met Leu Leu Leu Val Thr Ser Leu Leu Leu Cys Glu Leu Pro His Pro 
1               5                   10                  15      


Ala Phe Leu Leu Ile Pro Glu Val Gln Leu Val Gln Ser Gly Ala Glu 
            20                  25                  30          


Val Lys Lys Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly 
        35                  40                  45              


Phe Thr Phe Ser Ser Tyr Ser Met Asn Trp Val Arg Gln Ala Pro Gly 
    50                  55                  60                  


Lys Gly Leu Glu Trp Val Ser Ser Ile Ser Ser Ser Ser Ser Tyr Ile 
65                  70                  75                  80  


Tyr Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn 
                85                  90                  95      


Ala Lys Asn Ser Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp 
            100                 105                 110         


Thr Ala Val Tyr Tyr Cys Ala Ile Glu Ser Trp Gly Ser Leu Asp Tyr 
        115                 120                 125             


Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser 
    130                 135                 140                 


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Ser Val Leu Thr Gln 
145                 150                 155                 160 


Pro Pro Ser Val Ser Ala Ala Pro Gly Gln Lys Val Thr Ile Ser Cys 
                165                 170                 175     


Ser Gly Ser Ser Ser Asn Ile Gly Asp Asp Tyr Val Ser Trp Tyr Gln 
            180                 185                 190         


Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu Ile Tyr Asp Asn His Lys 
        195                 200                 205             


Arg Pro Ser Gly Ile Pro Asp Arg Phe Ser Gly Ser Lys Ser Gly Thr 
    210                 215                 220                 


Ser Ala Thr Leu Gly Ile Thr Gly Leu Gln Thr Gly Asp Glu Ala Asp 
225                 230                 235                 240 


Tyr Tyr Cys Gly Thr Trp Asp Asp Ser Leu Ser Gly Val Val Phe Gly 
                245                 250                 255     


Gly Gly Thr Lys Leu Thr Val Leu Gly Ala Ala Ala Thr Thr Thr Pro 
            260                 265                 270         


Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu 
        275                 280                 285             


Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala Val His 
    290                 295                 300                 


Thr Arg Gly Leu Asp Phe Ala Cys Asp Ile Tyr Ile Trp Ala Pro Leu 
305                 310                 315                 320 


Ala Gly Thr Cys Gly Val Leu Leu Leu Ser Leu Val Ile Thr Leu Tyr 
                325                 330                 335     


Cys Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe 
            340                 345                 350         


Met Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg 
        355                 360                 365             


Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu Arg Val Lys Phe Ser 
    370                 375                 380                 


Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly Gln Asn Gln Leu Tyr 
385                 390                 395                 400 


Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys 
                405                 410                 415     


Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg Arg Lys Asn 
            420                 425                 430         


Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu 
        435                 440                 445             


Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly 
    450                 455                 460                 


His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr 
465                 470                 475                 480 


Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
                485                 490     


<210>  77
<211>  1464
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  LTG 2075 (hScFv aCD123 CD8 TM 4-1BB CD3 zeta)

<400>  77
atgctgctgc tggtgaccag cctgctgctg tgcgaactgc cgcatccggc gtttctgctg       60

attccggaag tgcaactcgt cgaaactgga gccgaagtga aaaagcctgg agcgtccgtc      120

aaagtgtcgt gcaaggcctc cggctacacc ttcacgacct actacgtgca ctgggtcaga      180

caggctccgg gtcaagggct ggagtggatg ggcatcatta acccctccgg tggaagcacc      240

tcctatgcgc aaaagttcca gggtcgcgtc accatgactc gcgatacctc cacttccact      300

gtgtacatgg aactgagctc cctgaggtcc gaggacaccg ccgtgtacta ctgcgcacgg      360

gatggaggct tgggcggcta cgaggcttgg ggacagggca ccctcgtgac tgtgtcaagc      420

ggagggggtg gatccggagg gggaggatca ggcggtggtg gaagcgatat ccagcttacc      480

cagtcgcctt ccgcgctgtc tgcatcggcc ggcgacagag tgacaattac ctgtcaagcc      540

agccaggaca tctccaacta tctgaactgg taccagcaga agcccggaaa ggctccgaag      600

ctgctgatct acgacgccag caacctggaa cggggcgtgc catcacggtt ctcgggatca      660

gggtcgggca ctgagttcac cttcaccatc tcctccctcc aacccgagga cattgccacc      720

tactactgcc agcagtacga caacctcccg atcacctttg gacaggggac tcgcctggaa      780

atcaaggcgg ccgcaactac cacccctgcc cctcggccgc cgactccggc cccaaccatc      840

gcaagccaac ccctctcctt gcgccccgaa gcttgccgcc cggccgcggg tggagccgtg      900

catacccggg ggctggactt tgcctgcgat atctacattt gggccccgct ggccggcact      960

tgcggcgtgc tcctgctgtc gctggtcatc accctttact gcaagagggg ccggaagaag     1020

ctgctttaca tcttcaagca gccgttcatg cggcccgtgc agacgactca ggaagaggac     1080

ggatgctcgt gcagattccc tgaggaggaa gaggggggat gcgaactgcg cgtcaagttc     1140

tcacggtccg ccgacgcccc cgcatatcaa cagggccaga atcagctcta caacgagctg     1200

aacctgggaa ggagagagga gtacgacgtg ctggacaagc gacgcggacg cgacccggag     1260

atggggggga aaccacggcg gaaaaaccct caggaaggac tgtacaacga actccagaaa     1320

gacaagatgg cggaagccta ctcagaaatc gggatgaagg gagagcggag gaggggaaag     1380

ggtcacgacg ggctgtacca gggactgagc accgccacta aggataccta cgatgccttg     1440

catatgcaag cactcccacc ccgg                                            1464


<210>  78
<211>  488
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LTG 2075 (hScFv aCD123 CD8 TM 4-1BB CD3 zeta)

<400>  78

Met Leu Leu Leu Val Thr Ser Leu Leu Leu Cys Glu Leu Pro His Pro 
1               5                   10                  15      


Ala Phe Leu Leu Ile Pro Glu Val Gln Leu Val Glu Thr Gly Ala Glu 
            20                  25                  30          


Val Lys Lys Pro Gly Ala Ser Val Lys Val Ser Cys Lys Ala Ser Gly 
        35                  40                  45              


Tyr Thr Phe Thr Thr Tyr Tyr Val His Trp Val Arg Gln Ala Pro Gly 
    50                  55                  60                  


Gln Gly Leu Glu Trp Met Gly Ile Ile Asn Pro Ser Gly Gly Ser Thr 
65                  70                  75                  80  


Ser Tyr Ala Gln Lys Phe Gln Gly Arg Val Thr Met Thr Arg Asp Thr 
                85                  90                  95      


Ser Thr Ser Thr Val Tyr Met Glu Leu Ser Ser Leu Arg Ser Glu Asp 
            100                 105                 110         


Thr Ala Val Tyr Tyr Cys Ala Arg Asp Gly Gly Leu Gly Gly Tyr Glu 
        115                 120                 125             


Ala Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly 
    130                 135                 140                 


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Gln Leu Thr 
145                 150                 155                 160 


Gln Ser Pro Ser Ala Leu Ser Ala Ser Ala Gly Asp Arg Val Thr Ile 
                165                 170                 175     


Thr Cys Gln Ala Ser Gln Asp Ile Ser Asn Tyr Leu Asn Trp Tyr Gln 
            180                 185                 190         


Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr Asp Ala Ser Asn 
        195                 200                 205             


Leu Glu Arg Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr 
    210                 215                 220                 


Glu Phe Thr Phe Thr Ile Ser Ser Leu Gln Pro Glu Asp Ile Ala Thr 
225                 230                 235                 240 


Tyr Tyr Cys Gln Gln Tyr Asp Asn Leu Pro Ile Thr Phe Gly Gln Gly 
                245                 250                 255     


Thr Arg Leu Glu Ile Lys Ala Ala Ala Thr Thr Thr Pro Ala Pro Arg 
            260                 265                 270         


Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg 
        275                 280                 285             


Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala Val His Thr Arg Gly 
    290                 295                 300                 


Leu Asp Phe Ala Cys Asp Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr 
305                 310                 315                 320 


Cys Gly Val Leu Leu Leu Ser Leu Val Ile Thr Leu Tyr Cys Lys Arg 
                325                 330                 335     


Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met Arg Pro 
            340                 345                 350         


Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe Pro Glu 
        355                 360                 365             


Glu Glu Glu Gly Gly Cys Glu Leu Arg Val Lys Phe Ser Arg Ser Ala 
    370                 375                 380                 


Asp Ala Pro Ala Tyr Gln Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu 
385                 390                 395                 400 


Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly 
                405                 410                 415     


Arg Asp Pro Glu Met Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu 
            420                 425                 430         


Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser 
        435                 440                 445             


Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly 
    450                 455                 460                 


Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu 
465                 470                 475                 480 


His Met Gln Ala Leu Pro Pro Arg 
                485             


<210>  79
<211>  36
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  human IgG4 hinge

<400>  79
gagagcaaat acgggccgcc atgtcccccg tgtccg                                 36


<210>  80
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  human IgG4 hinge

<400>  80

Glu Ser Lys Tyr Gly Pro Pro Cys Pro Pro Cys Pro 
1               5                   10          


<210>  81
<211>  327
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  human IgG4 CH2 domain

<400>  81
gcaccaccag ttgctggccc tagtgtcttc ttgttccctc ccaagcccaa agacaccttg       60

atgatttcca gaactcctga ggttacctgc gttgtcgtag atgtttctca ggaggaccca      120

gaggtccaat ttaactggta cgttgatggg gtggaagttc acaatgcgaa gacaaagccg      180

cgggaagaac aatttcagtc cacttaccgg gttgtcagcg ttctgacggt attgcatcaa      240

gactggctta atggaaagga atataagtgt aaggtgtcca acaaaggttt gccgagcagt      300

attgagaaga ccatatcaaa ggcgaag                                          327


<210>  82
<211>  109
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  human IgG4 CH2 domain

<400>  82

Ala Pro Pro Val Ala Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro 
1               5                   10                  15      


Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val 
            20                  25                  30          


Val Asp Val Ser Gln Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val 
        35                  40                  45              


Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln 
    50                  55                  60                  


Phe Gln Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln 
65                  70                  75                  80  


Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly 
                85                  90                  95      


Leu Pro Ser Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys 
            100                 105                 


<210>  83
<211>  321
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  human IgG4 CH3 domain

<400>  83
gggcagccgc gcgagccaca agtttacact ttgccgccat ctcaagagga aatgactaaa       60

aaccaggtat ccttgacatg cctcgtaaaa ggattttatc catctgatat tgctgtggaa      120

tgggagtcta acgggcagcc ggaaaataat tacaaaacta caccacctgt gctcgattca      180

gatggaagtt tcttccttta cagtagactt acggtggaca aatctaggtg gcaggaaggg      240

aatgtgttta gttgtagtgt aatgcacgag gcacttcata accactatac acagaagtca      300

ctgagtttga gtcttggcaa a                                                321


<210>  84
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  human IgG4 CH3 domain

<400>  84

Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Gln Glu 
1               5                   10                  15      


Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe 
            20                  25                  30          


Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu 
        35                  40                  45              


Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe 
    50                  55                  60                  


Phe Leu Tyr Ser Arg Leu Thr Val Asp Lys Ser Arg Trp Gln Glu Gly 
65                  70                  75                  80  


Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr 
                85                  90                  95      


Thr Gln Lys Ser Leu Ser Leu Ser Leu Gly Lys 
            100                 105         


<210>  85
<211>  684
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  human IgG4 hinge CH2 CH3 domain

<400>  85
gagagcaaat acgggccgcc atgtcccccg tgtccggcac caccagttgc tggccctagt       60

gtcttcttgt tccctcccaa gcccaaagac accttgatga tttccagaac tcctgaggtt      120

acctgcgttg tcgtagatgt ttctcaggag gacccagagg tccaatttaa ctggtacgtt      180

gatggggtgg aagttcacaa tgcgaagaca aagccgcggg aagaacaatt tcagtccact      240

taccgggttg tcagcgttct gacggtattg catcaagact ggcttaatgg aaaggaatat      300

aagtgtaagg tgtccaacaa aggtttgccg agcagtattg agaagaccat atcaaaggcg      360

aaggggcagc cgcgcgagcc acaagtttac actttgccgc catctcaaga ggaaatgact      420

aaaaaccagg tatccttgac atgcctcgta aaaggatttt atccatctga tattgctgtg      480

gaatgggagt ctaacgggca gccggaaaat aattacaaaa ctacaccacc tgtgctcgat      540

tcagatggaa gtttcttcct ttacagtaga cttacggtgg acaaatctag gtggcaggaa      600

gggaatgtgt ttagttgtag tgtaatgcac gaggcacttc ataaccacta tacacagaag      660

tcactgagtt tgagtcttgg caaa                                             684


<210>  86
<211>  228
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  human IgG4 hinge CH2 CH3 domain

<400>  86

Glu Ser Lys Tyr Gly Pro Pro Cys Pro Pro Cys Pro Ala Pro Pro Val 
1               5                   10                  15      


Ala Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu 
            20                  25                  30          


Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser 
        35                  40                  45              


Gln Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu 
    50                  55                  60                  


Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe Gln Ser Thr 
65                  70                  75                  80  


Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn 
                85                  90                  95      


Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu Pro Ser Ser 
            100                 105                 110         


Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln 
        115                 120                 125             


Val Tyr Thr Leu Pro Pro Ser Gln Glu Glu Met Thr Lys Asn Gln Val 
    130                 135                 140                 


Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val 
145                 150                 155                 160 


Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro 
                165                 170                 175     


Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Arg Leu Thr 
            180                 185                 190         


Val Asp Lys Ser Arg Trp Gln Glu Gly Asn Val Phe Ser Cys Ser Val 
        195                 200                 205             


Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu 
    210                 215                 220                 


Ser Leu Gly Lys 
225             


<210>  87
<211>  1503
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  LTG 2076 (hScFv aCD123 CD8 TM 4-1BB CD3 zeta)

<400>  87
atgctgctgc tggtgaccag cctgctgctg tgcgaactgc cgcatccggc gtttctgctg       60

attccggaag tgcaattggt ccagagcgga ggaggacttg tgaagccagg cggatccctg      120

agattgtcat gcgccgcatc ggggttcacc ttttcctcct actccatgaa ctgggtcaga      180

caggcgcccg gaaagggact tgaatgggtg tcgtccattt cctcctcctc gtcctacatc      240

tactacgccg actccgtgaa gggccgcttc accatctccc gggacaacgc caagaacagc      300

ctgtatctcc aaatgaactc cctgcgggcc gaagatactg ctgtgtatta ctgcgctcgg      360

gacttcccgt acgactcatc gggctattac tcggacgcgt tcgatatctg gggccaggga      420

actatggtca ccgtcagctc tggtggcggt ggttccggag ggggtggatc cggtggcgga      480

ggatcagaga ttgtgctgac ccagtccccg ctgtcactgc ccgtgactcc gggagagcct      540

gcctcgatct cgtgtcggtc cagccagtcc ctgctgcact cgaatgggta caactacctc      600

gattggtacc tccaaaagcc tgggcagtca ccccaactgc tgatctacct cgggagcaac      660

agagccagcg gagtgcctga ccgctttagc ggttccggat ccggcaccga cttcaccctg      720

aaaatcagcc gggtggaagc cgaggatgtc ggcgtgtact actgcatgca ggcactgcag      780

actctggggt acaccttcgg ccagggcacg aagctcgaga tcaaggcggc cgcaactacc      840

acccctgccc ctcggccgcc gactccggcc ccaaccatcg caagccaacc cctctccttg      900

cgccccgaag cttgccgccc ggccgcgggt ggagccgtgc atacccgggg gctggacttt      960

gcctgcgata tctacatttg ggccccgctg gccggcactt gcggcgtgct cctgctgtcg     1020

ctggtcatca ccctttactg caagaggggc cggaagaagc tgctttacat cttcaagcag     1080

ccgttcatgc ggcccgtgca gacgactcag gaagaggacg gatgctcgtg cagattccct     1140

gaggaggaag aggggggatg cgaactgcgc gtcaagttct cacggtccgc cgacgccccc     1200

gcatatcaac agggccagaa tcagctctac aacgagctga acctgggaag gagagaggag     1260

tacgacgtgc tggacaagcg acgcggacgc gacccggaga tgggggggaa accacggcgg     1320

aaaaaccctc aggaaggact gtacaacgaa ctccagaaag acaagatggc ggaagcctac     1380

tcagaaatcg ggatgaaggg agagcggagg aggggaaagg gtcacgacgg gctgtaccag     1440

ggactgagca ccgccactaa ggatacctac gatgccttgc atatgcaagc actcccaccc     1500

cgg                                                                   1503


<210>  88
<211>  501
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LTG 2076 (hScFv aCD123 CD8 TM 4-1BB CD3 zeta)

<400>  88

Met Leu Leu Leu Val Thr Ser Leu Leu Leu Cys Glu Leu Pro His Pro 
1               5                   10                  15      


Ala Phe Leu Leu Ile Pro Glu Val Gln Leu Val Gln Ser Gly Gly Gly 
            20                  25                  30          


Leu Val Lys Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly 
        35                  40                  45              


Phe Thr Phe Ser Ser Tyr Ser Met Asn Trp Val Arg Gln Ala Pro Gly 
    50                  55                  60                  


Lys Gly Leu Glu Trp Val Ser Ser Ile Ser Ser Ser Ser Ser Tyr Ile 
65                  70                  75                  80  


Tyr Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn 
                85                  90                  95      


Ala Lys Asn Ser Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp 
            100                 105                 110         


Thr Ala Val Tyr Tyr Cys Ala Arg Asp Phe Pro Tyr Asp Ser Ser Gly 
        115                 120                 125             


Tyr Tyr Ser Asp Ala Phe Asp Ile Trp Gly Gln Gly Thr Met Val Thr 
    130                 135                 140                 


Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
145                 150                 155                 160 


Gly Ser Glu Ile Val Leu Thr Gln Ser Pro Leu Ser Leu Pro Val Thr 
                165                 170                 175     


Pro Gly Glu Pro Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu Leu 
            180                 185                 190         


His Ser Asn Gly Tyr Asn Tyr Leu Asp Trp Tyr Leu Gln Lys Pro Gly 
        195                 200                 205             


Gln Ser Pro Gln Leu Leu Ile Tyr Leu Gly Ser Asn Arg Ala Ser Gly 
    210                 215                 220                 


Val Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu 
225                 230                 235                 240 


Lys Ile Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Met 
                245                 250                 255     


Gln Ala Leu Gln Thr Leu Gly Tyr Thr Phe Gly Gln Gly Thr Lys Leu 
            260                 265                 270         


Glu Ile Lys Ala Ala Ala Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr 
        275                 280                 285             


Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala 
    290                 295                 300                 


Cys Arg Pro Ala Ala Gly Gly Ala Val His Thr Arg Gly Leu Asp Phe 
305                 310                 315                 320 


Ala Cys Asp Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr Cys Gly Val 
                325                 330                 335     


Leu Leu Leu Ser Leu Val Ile Thr Leu Tyr Cys Lys Arg Gly Arg Lys 
            340                 345                 350         


Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met Arg Pro Val Gln Thr 
        355                 360                 365             


Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe Pro Glu Glu Glu Glu 
    370                 375                 380                 


Gly Gly Cys Glu Leu Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro 
385                 390                 395                 400 


Ala Tyr Gln Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly 
                405                 410                 415     


Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro 
            420                 425                 430         


Glu Met Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr 
        435                 440                 445             


Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly 
    450                 455                 460                 


Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln 
465                 470                 475                 480 


Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln 
                485                 490                 495     


Ala Leu Pro Pro Arg 
            500     


<210>  89
<211>  1491
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  LTG 2077 (hScFv aCD123 CD8 TM 4-1BB CD3 zeta)

<400>  89
atgctgctgc tggtgaccag cctgctgctg tgcgaactgc cgcatccggc gtttctgctg       60

attccgcaag tgcaactcgt ccaatccggt gccgaagtca agaagcctgg ttcctccgtg      120

aaagtgtcgt gcaaagccag cggcgggact tttagctcct acgcgatcag ctgggtcaga      180

caggcccctg gacaaggcct cgagtggatg ggcggcatca ttccgatttt cggtaccgcc      240

aactacgccc agaagttcca gggacgcgtg accattacta ccgacgagag cacctcaacc      300

gcatacatgg aactgtccag cctgcgctcc gaggacacgg ctgtgtacta ttgcgccaga      360

cggggatggg gaggattctc ctccggctcc gcattcgaca tctggggaca gggcactatg      420

gtcactgtgt catccggggg aggaggatca ggcggtggag gatccggtgg tggcggatcc      480

aacttcatgc tgacccagcc ccactcagtg tcggaatcgc ccggcaacac cgtgactatc      540

agctgcaccg gatccagcgg gaccatcggc tctaatttcg tgcagtggta ccagcagtcc      600

ccagggagag ctccgaccct gttgatctac gaggacacaa agcggccaag cggagtgccg      660

cctagattcg ccggctccgt ggattcctcg tccaactcgg cgtcgctgac catcagcgga      720

ctcaagactg aagatgaagc cgactactac tgtcagtcct acgactcgag caactgggtg      780

tttgggggcg ggactaagct gaccgtgctt ggagcggccg caactaccac ccctgcccct      840

cggccgccga ctccggcccc aaccatcgca agccaacccc tctccttgcg ccccgaagct      900

tgccgcccgg ccgcgggtgg agccgtgcat acccgggggc tggactttgc ctgcgatatc      960

tacatttggg ccccgctggc cggcacttgc ggcgtgctcc tgctgtcgct ggtcatcacc     1020

ctttactgca agaggggccg gaagaagctg ctttacatct tcaagcagcc gttcatgcgg     1080

cccgtgcaga cgactcagga agaggacgga tgctcgtgca gattccctga ggaggaagag     1140

gggggatgcg aactgcgcgt caagttctca cggtccgccg acgcccccgc atatcaacag     1200

ggccagaatc agctctacaa cgagctgaac ctgggaagga gagaggagta cgacgtgctg     1260

gacaagcgac gcggacgcga cccggagatg ggggggaaac cacggcggaa aaaccctcag     1320

gaaggactgt acaacgaact ccagaaagac aagatggcgg aagcctactc agaaatcggg     1380

atgaagggag agcggaggag gggaaagggt cacgacgggc tgtaccaggg actgagcacc     1440

gccactaagg atacctacga tgccttgcat atgcaagcac tcccaccccg g              1491


<210>  90
<211>  497
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LTG 2077 (hScFv aCD123 CD8 TM 4-1BB CD3 zeta)

<400>  90

Met Leu Leu Leu Val Thr Ser Leu Leu Leu Cys Glu Leu Pro His Pro 
1               5                   10                  15      


Ala Phe Leu Leu Ile Pro Gln Val Gln Leu Val Gln Ser Gly Ala Glu 
            20                  25                  30          


Val Lys Lys Pro Gly Ser Ser Val Lys Val Ser Cys Lys Ala Ser Gly 
        35                  40                  45              


Gly Thr Phe Ser Ser Tyr Ala Ile Ser Trp Val Arg Gln Ala Pro Gly 
    50                  55                  60                  


Gln Gly Leu Glu Trp Met Gly Gly Ile Ile Pro Ile Phe Gly Thr Ala 
65                  70                  75                  80  


Asn Tyr Ala Gln Lys Phe Gln Gly Arg Val Thr Ile Thr Thr Asp Glu 
                85                  90                  95      


Ser Thr Ser Thr Ala Tyr Met Glu Leu Ser Ser Leu Arg Ser Glu Asp 
            100                 105                 110         


Thr Ala Val Tyr Tyr Cys Ala Arg Arg Gly Trp Gly Gly Phe Ser Ser 
        115                 120                 125             


Gly Ser Ala Phe Asp Ile Trp Gly Gln Gly Thr Met Val Thr Val Ser 
    130                 135                 140                 


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
145                 150                 155                 160 


Asn Phe Met Leu Thr Gln Pro His Ser Val Ser Glu Ser Pro Gly Asn 
                165                 170                 175     


Thr Val Thr Ile Ser Cys Thr Gly Ser Ser Gly Thr Ile Gly Ser Asn 
            180                 185                 190         


Phe Val Gln Trp Tyr Gln Gln Ser Pro Gly Arg Ala Pro Thr Leu Leu 
        195                 200                 205             


Ile Tyr Glu Asp Thr Lys Arg Pro Ser Gly Val Pro Pro Arg Phe Ala 
    210                 215                 220                 


Gly Ser Val Asp Ser Ser Ser Asn Ser Ala Ser Leu Thr Ile Ser Gly 
225                 230                 235                 240 


Leu Lys Thr Glu Asp Glu Ala Asp Tyr Tyr Cys Gln Ser Tyr Asp Ser 
                245                 250                 255     


Ser Asn Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Ala 
            260                 265                 270         


Ala Ala Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr 
        275                 280                 285             


Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala 
    290                 295                 300                 


Ala Gly Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp Ile 
305                 310                 315                 320 


Tyr Ile Trp Ala Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu Ser 
                325                 330                 335     


Leu Val Ile Thr Leu Tyr Cys Lys Arg Gly Arg Lys Lys Leu Leu Tyr 
            340                 345                 350         


Ile Phe Lys Gln Pro Phe Met Arg Pro Val Gln Thr Thr Gln Glu Glu 
        355                 360                 365             


Asp Gly Cys Ser Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu 
    370                 375                 380                 


Leu Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln 
385                 390                 395                 400 


Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu 
                405                 410                 415     


Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly 
            420                 425                 430         


Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln 
        435                 440                 445             


Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu 
    450                 455                 460                 


Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr 
465                 470                 475                 480 


Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro 
                485                 490                 495     


Arg 
    


<210>  91
<211>  1479
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  LTG 2078 (hScFv aCD123 CD8 TM 4-1BB CD3 zeta)

<400>  91
atgctgctgc tggtgaccag cctgctgctg tgcgaactgc cgcatccggc gtttctgctg       60

attccggaag tccaattggt gcagagcgga tccgaactta agaaacctgg cgcgagcgtg      120

aaagtgtcct gcaaggcctc cggagggact ttctcgtcgt acgccattag ctgggtccgc      180

caagctcctg gccaaggcct ggagtggatg ggcgggatta tccccatctt cgggactgcg      240

aactacgccc agaagtttca gggccgggtc actatcaccg ccgacgaatc aacctcgacc      300

gcctacatgg aactgtcctc gcttcggtcc gaggatactg ccgtgtacta ttgtgcctca      360

acggccagac gcggatggga caccgctggt ccgctcgatt actggggcca gggaaccctc      420

gtgaccgtca gctccggagg aggaggctcc ggtggtggag gatccggggg tggtggatcc      480

gacatccaaa tgacccagtc cccctcgtcc ctgagcgcct ctgtgggcga cagagtgaca      540

attgcatgca gggcctcaca gactatctcc cgctacctga actggtacca gcagaagcca      600

ggaaaggccc ctaagctgct catctacgct gcgtcctcgc tccaatccgg ggtgtcctca      660

cggttttccg gatcgggttc cggcaccgag ttcaccctga ccatcagcag cctgcagccc      720

gaggacttcg caacctactt ctgccagcaa acctactccc cgccgattac gttcggacag      780

gggactcggc tggaaatcaa ggcggccgca actaccaccc ctgcccctcg gccgccgact      840

ccggccccaa ccatcgcaag ccaacccctc tccttgcgcc ccgaagcttg ccgcccggcc      900

gcgggtggag ccgtgcatac ccgggggctg gactttgcct gcgatatcta catttgggcc      960

ccgctggccg gcacttgcgg cgtgctcctg ctgtcgctgg tcatcaccct ttactgcaag     1020

aggggccgga agaagctgct ttacatcttc aagcagccgt tcatgcggcc cgtgcagacg     1080

actcaggaag aggacggatg ctcgtgcaga ttccctgagg aggaagaggg gggatgcgaa     1140

ctgcgcgtca agttctcacg gtccgccgac gcccccgcat atcaacaggg ccagaatcag     1200

ctctacaacg agctgaacct gggaaggaga gaggagtacg acgtgctgga caagcgacgc     1260

ggacgcgacc cggagatggg ggggaaacca cggcggaaaa accctcagga aggactgtac     1320

aacgaactcc agaaagacaa gatggcggaa gcctactcag aaatcgggat gaagggagag     1380

cggaggaggg gaaagggtca cgacgggctg taccagggac tgagcaccgc cactaaggat     1440

acctacgatg ccttgcatat gcaagcactc ccaccccgg                            1479


<210>  92
<211>  493
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LTG 2078 (hScFv aCD123 CD8 TM 4-1BB CD3 zeta)

<400>  92

Met Leu Leu Leu Val Thr Ser Leu Leu Leu Cys Glu Leu Pro His Pro 
1               5                   10                  15      


Ala Phe Leu Leu Ile Pro Glu Val Gln Leu Val Gln Ser Gly Ser Glu 
            20                  25                  30          


Leu Lys Lys Pro Gly Ala Ser Val Lys Val Ser Cys Lys Ala Ser Gly 
        35                  40                  45              


Gly Thr Phe Ser Ser Tyr Ala Ile Ser Trp Val Arg Gln Ala Pro Gly 
    50                  55                  60                  


Gln Gly Leu Glu Trp Met Gly Gly Ile Ile Pro Ile Phe Gly Thr Ala 
65                  70                  75                  80  


Asn Tyr Ala Gln Lys Phe Gln Gly Arg Val Thr Ile Thr Ala Asp Glu 
                85                  90                  95      


Ser Thr Ser Thr Ala Tyr Met Glu Leu Ser Ser Leu Arg Ser Glu Asp 
            100                 105                 110         


Thr Ala Val Tyr Tyr Cys Ala Ser Thr Ala Arg Arg Gly Trp Asp Thr 
        115                 120                 125             


Ala Gly Pro Leu Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser 
    130                 135                 140                 


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
145                 150                 155                 160 


Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
                165                 170                 175     


Asp Arg Val Thr Ile Ala Cys Arg Ala Ser Gln Thr Ile Ser Arg Tyr 
            180                 185                 190         


Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        195                 200                 205             


Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Ser Ser Arg Phe Ser Gly 
    210                 215                 220                 


Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
225                 230                 235                 240 


Glu Asp Phe Ala Thr Tyr Phe Cys Gln Gln Thr Tyr Ser Pro Pro Ile 
                245                 250                 255     


Thr Phe Gly Gln Gly Thr Arg Leu Glu Ile Lys Ala Ala Ala Thr Thr 
            260                 265                 270         


Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln 
        275                 280                 285             


Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala 
    290                 295                 300                 


Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp Ile Tyr Ile Trp Ala 
305                 310                 315                 320 


Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu Ser Leu Val Ile Thr 
                325                 330                 335     


Leu Tyr Cys Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln 
            340                 345                 350         


Pro Phe Met Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser 
        355                 360                 365             


Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu Arg Val Lys 
    370                 375                 380                 


Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly Gln Asn Gln 
385                 390                 395                 400 


Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu 
                405                 410                 415     


Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg Arg 
            420                 425                 430         


Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met 
        435                 440                 445             


Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly 
    450                 455                 460                 


Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp 
465                 470                 475                 480 


Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
                485                 490             


<210>  93
<211>  1473
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  LTG 2079 (hScFv aCD123 CD8 TM 4-1BB CD3 zeta)

<400>  93
atgctgctgc tggtgaccag cctgctgctg tgcgaactgc cgcatccggc gtttctgctg       60

attccggaag tgcaactcgt cgaaacaggg gcagaagtga aaaacccagg ctcaagcgtg      120

aaagtgtcgt gcaaggcttc gggcggaact ctgtccaact acgccatctc ctgggtccgc      180

caagctccgg gaaagggcct cgagtggatg ggcggaatca ttcccatttt cgggaccgcc      240

aactacgcgc aaaagttcca gggccgggtc actatcaccg cggacgaaag caccagcacc      300

gcctacatgg aactgtcctc cctgcgctcc gaggacactg ccgtgtacta ttgcgcccgg      360

aggtcatcgt ggtaccccga gggctgcttc cagcactggg gacagggcac tctcgtgacc      420

gtgtcgtcgg gtggtggtgg atcaggaggg ggaggatccg gaggaggcgg aagcgatatt      480

cagctgaccc agtcaccgag ctccctgtcc gcctccaccg gagacagagt gaccatcacg      540

tgtcgggcct cccaagggat ctcctcctac ctggcctggt accagcagaa gcctggaaag      600

gcaccgaagt tgctgatcta cgccgcgagc acccttcagt ccggagtgcc tagccgcttc      660

tcgggttccg gctctggcac tgacttcact ctgaccatta gctgcctgca gtccgaggat      720

tttgccacct actactgcca gcagtactat agctaccccc tgaccttcgg gggcggaacc      780

aagctcgaca tcaaggcggc cgcaactacc acccctgccc ctcggccgcc gactccggcc      840

ccaaccatcg caagccaacc cctctccttg cgccccgaag cttgccgccc ggccgcgggt      900

ggagccgtgc atacccgggg gctggacttt gcctgcgata tctacatttg ggccccgctg      960

gccggcactt gcggcgtgct cctgctgtcg ctggtcatca ccctttactg caagaggggc     1020

cggaagaagc tgctttacat cttcaagcag ccgttcatgc ggcccgtgca gacgactcag     1080

gaagaggacg gatgctcgtg cagattccct gaggaggaag aggggggatg cgaactgcgc     1140

gtcaagttct cacggtccgc cgacgccccc gcatatcaac agggccagaa tcagctctac     1200

aacgagctga acctgggaag gagagaggag tacgacgtgc tggacaagcg acgcggacgc     1260

gacccggaga tgggggggaa accacggcgg aaaaaccctc aggaaggact gtacaacgaa     1320

ctccagaaag acaagatggc ggaagcctac tcagaaatcg ggatgaaggg agagcggagg     1380

aggggaaagg gtcacgacgg gctgtaccag ggactgagca ccgccactaa ggatacctac     1440

gatgccttgc atatgcaagc actcccaccc cgg                                  1473


<210>  94
<211>  491
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LTG 2079 (hScFv aCD123 CD8 TM 4-1BB CD3 zeta)

<400>  94

Met Leu Leu Leu Val Thr Ser Leu Leu Leu Cys Glu Leu Pro His Pro 
1               5                   10                  15      


Ala Phe Leu Leu Ile Pro Glu Val Gln Leu Val Glu Thr Gly Ala Glu 
            20                  25                  30          


Val Lys Asn Pro Gly Ser Ser Val Lys Val Ser Cys Lys Ala Ser Gly 
        35                  40                  45              


Gly Thr Leu Ser Asn Tyr Ala Ile Ser Trp Val Arg Gln Ala Pro Gly 
    50                  55                  60                  


Lys Gly Leu Glu Trp Met Gly Gly Ile Ile Pro Ile Phe Gly Thr Ala 
65                  70                  75                  80  


Asn Tyr Ala Gln Lys Phe Gln Gly Arg Val Thr Ile Thr Ala Asp Glu 
                85                  90                  95      


Ser Thr Ser Thr Ala Tyr Met Glu Leu Ser Ser Leu Arg Ser Glu Asp 
            100                 105                 110         


Thr Ala Val Tyr Tyr Cys Ala Arg Arg Ser Ser Trp Tyr Pro Glu Gly 
        115                 120                 125             


Cys Phe Gln His Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly 
    130                 135                 140                 


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile 
145                 150                 155                 160 


Gln Leu Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Thr Gly Asp Arg 
                165                 170                 175     


Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Ser Ser Tyr Leu Ala 
            180                 185                 190         


Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr Ala 
        195                 200                 205             


Ala Ser Thr Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Gly 
    210                 215                 220                 


Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Cys Leu Gln Ser Glu Asp 
225                 230                 235                 240 


Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Tyr Ser Tyr Pro Leu Thr Phe 
                245                 250                 255     


Gly Gly Gly Thr Lys Leu Asp Ile Lys Ala Ala Ala Thr Thr Thr Pro 
            260                 265                 270         


Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu 
        275                 280                 285             


Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala Val His 
    290                 295                 300                 


Thr Arg Gly Leu Asp Phe Ala Cys Asp Ile Tyr Ile Trp Ala Pro Leu 
305                 310                 315                 320 


Ala Gly Thr Cys Gly Val Leu Leu Leu Ser Leu Val Ile Thr Leu Tyr 
                325                 330                 335     


Cys Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe 
            340                 345                 350         


Met Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg 
        355                 360                 365             


Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu Arg Val Lys Phe Ser 
    370                 375                 380                 


Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly Gln Asn Gln Leu Tyr 
385                 390                 395                 400 


Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys 
                405                 410                 415     


Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg Arg Lys Asn 
            420                 425                 430         


Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu 
        435                 440                 445             


Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly 
    450                 455                 460                 


His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr 
465                 470                 475                 480 


Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
                485                 490     


<210>  95
<211>  1485
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  LTG 2080 (hScFv aCD123 CD8 TM 4-1BB CD3 zeta)

<400>  95
atgctgctgc tggtgaccag cctgctgctg tgcgaactgc cgcatccggc gtttctgctg       60

attccggaag tccaattggt gcagagcgga gctgaagtga agaaacctgg cgcgaccgtg      120

aagatctcgt gcaaagtgtc cggctacact ttcaccgact actatatgca ctgggtgcaa      180

caggcgccgg gaaagggact ggagtggatt ggccttgtgg accccgaaga tggcgaaacc      240

atctacgccg agaagttcca gggccgggtc actatcaccg cggacacttc cacggacacc      300

gcctacatgg aactgagctc cctgagatcc gaggacaccg ccgtgtacta ctgcgccact      360

gccccactgg gggaagtcgg cgcagcagtg gactactggg gacagggaac tctcgtcact      420

gtgtccagcg gtggaggagg cagcggtggt ggaggctccg gtggtggtgg atcccatgtc      480

attctgactc agccgccgtc agtgtcagcc gcccctggac aagaggtgtc catctcctgt      540

tcggggtccg atgccaacat tgggaccaac ttggtgtcgt ggtaccagca cgtgcctgga      600

acagccccca agctgctcat ctacgagaac tcgaagaggc catccggaat tcccgcccgg      660

ttttcatcga gccagtcagg gacctccgct accctggcta tcagcgggct ccagtctggg      720

gatgaagcga tctactactg cctgacctgg gatcgcaccc tctccggaaa gatcttcggt      780

ggcggcactc agctgaccgt gcttggagcg gccgcaacta ccacccctgc ccctcggccg      840

ccgactccgg ccccaaccat cgcaagccaa cccctctcct tgcgccccga agcttgccgc      900

ccggccgcgg gtggagccgt gcatacccgg gggctggact ttgcctgcga tatctacatt      960

tgggccccgc tggccggcac ttgcggcgtg ctcctgctgt cgctggtcat caccctttac     1020

tgcaagaggg gccggaagaa gctgctttac atcttcaagc agccgttcat gcggcccgtg     1080

cagacgactc aggaagagga cggatgctcg tgcagattcc ctgaggagga agagggggga     1140

tgcgaactgc gcgtcaagtt ctcacggtcc gccgacgccc ccgcatatca acagggccag     1200

aatcagctct acaacgagct gaacctggga aggagagagg agtacgacgt gctggacaag     1260

cgacgcggac gcgacccgga gatggggggg aaaccacggc ggaaaaaccc tcaggaagga     1320

ctgtacaacg aactccagaa agacaagatg gcggaagcct actcagaaat cgggatgaag     1380

ggagagcgga ggaggggaaa gggtcacgac gggctgtacc agggactgag caccgccact     1440

aaggatacct acgatgcctt gcatatgcaa gcactcccac cccgg                     1485


<210>  96
<211>  495
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LTG 2080 (hScFv aCD123 CD8 TM 4-1BB CD3 zeta)

<400>  96

Met Leu Leu Leu Val Thr Ser Leu Leu Leu Cys Glu Leu Pro His Pro 
1               5                   10                  15      


Ala Phe Leu Leu Ile Pro Glu Val Gln Leu Val Gln Ser Gly Ala Glu 
            20                  25                  30          


Val Lys Lys Pro Gly Ala Thr Val Lys Ile Ser Cys Lys Val Ser Gly 
        35                  40                  45              


Tyr Thr Phe Thr Asp Tyr Tyr Met His Trp Val Gln Gln Ala Pro Gly 
    50                  55                  60                  


Lys Gly Leu Glu Trp Ile Gly Leu Val Asp Pro Glu Asp Gly Glu Thr 
65                  70                  75                  80  


Ile Tyr Ala Glu Lys Phe Gln Gly Arg Val Thr Ile Thr Ala Asp Thr 
                85                  90                  95      


Ser Thr Asp Thr Ala Tyr Met Glu Leu Ser Ser Leu Arg Ser Glu Asp 
            100                 105                 110         


Thr Ala Val Tyr Tyr Cys Ala Thr Ala Pro Leu Gly Glu Val Gly Ala 
        115                 120                 125             


Ala Val Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly 
    130                 135                 140                 


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser His Val 
145                 150                 155                 160 


Ile Leu Thr Gln Pro Pro Ser Val Ser Ala Ala Pro Gly Gln Glu Val 
                165                 170                 175     


Ser Ile Ser Cys Ser Gly Ser Asp Ala Asn Ile Gly Thr Asn Leu Val 
            180                 185                 190         


Ser Trp Tyr Gln His Val Pro Gly Thr Ala Pro Lys Leu Leu Ile Tyr 
        195                 200                 205             


Glu Asn Ser Lys Arg Pro Ser Gly Ile Pro Ala Arg Phe Ser Ser Ser 
    210                 215                 220                 


Gln Ser Gly Thr Ser Ala Thr Leu Ala Ile Ser Gly Leu Gln Ser Gly 
225                 230                 235                 240 


Asp Glu Ala Ile Tyr Tyr Cys Leu Thr Trp Asp Arg Thr Leu Ser Gly 
                245                 250                 255     


Lys Ile Phe Gly Gly Gly Thr Gln Leu Thr Val Leu Gly Ala Ala Ala 
            260                 265                 270         


Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala 
        275                 280                 285             


Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly 
    290                 295                 300                 


Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp Ile Tyr Ile 
305                 310                 315                 320 


Trp Ala Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu Ser Leu Val 
                325                 330                 335     


Ile Thr Leu Tyr Cys Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe 
            340                 345                 350         


Lys Gln Pro Phe Met Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly 
        355                 360                 365             


Cys Ser Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu Arg 
    370                 375                 380                 


Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly Gln 
385                 390                 395                 400 


Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp 
                405                 410                 415     


Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro 
            420                 425                 430         


Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp 
        435                 440                 445             


Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg 
    450                 455                 460                 


Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr 
465                 470                 475                 480 


Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
                485                 490                 495 


<210>  97
<211>  1488
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  LTG 2081 (hScFv aCD123 CD8 TM 4-1BB CD3 zeta)

<400>  97
atgctgctgc tggtgaccag cctgctgctg tgcgaactgc cgcatccggc gtttctgctg       60

attccggaag tgcaacttgt ccaaagcgga gccgaagtga agaagccagg atcctccgtg      120

aaagtgtctt gcaaagcatc cggcggcact ttctcctcct acgccatctc ctgggtcaga      180

caggcgcctg gacagggtct ggagtggatg ggcattatca atcctagcgg tggctccact      240

tcgtatgccc agaagttcca gggtcgggtc accatgaccc gggatacttc aactagcacc      300

gtgtacatgg aactctcctc gctgcgctcg gacgataccg ccgtgtacta ctgtgcccgc      360

gagctgctct ggtttggaga gctggacacc tacggaatgg acgtctgggg acaggggacc      420

actgtgacgg tgtcgtcagg aggcggaggc tcaggagggg gtggttccgg agggggagga      480

tccctcccgg tgctgaccca gcccccaagc gtcagcgtgg ctccgggaaa gaccgcccgc      540

atcacatgcg gcgggaacaa catcggctcc aagtccgtgc attggtacca gcagaagcct      600

ggacaagcgc cggtgctggt catctacgac gactcagatc ggccctccgg cattcccgag      660

cggttcagcg gctccaactc gggcaacact gctactctga ccatctcgag ggtggaagcg      720

ggggacgaag cagattacta ctgccaagtc tgggactcca gctccgacca cggggtgttc      780

ggcggaggaa cccagctgac cgtgttggga gcggccgcaa ctaccacccc tgcccctcgg      840

ccgccgactc cggccccaac catcgcaagc caacccctct ccttgcgccc cgaagcttgc      900

cgcccggccg cgggtggagc cgtgcatacc cgggggctgg actttgcctg cgatatctac      960

atttgggccc cgctggccgg cacttgcggc gtgctcctgc tgtcgctggt catcaccctt     1020

tactgcaaga ggggccggaa gaagctgctt tacatcttca agcagccgtt catgcggccc     1080

gtgcagacga ctcaggaaga ggacggatgc tcgtgcagat tccctgagga ggaagagggg     1140

ggatgcgaac tgcgcgtcaa gttctcacgg tccgccgacg cccccgcata tcaacagggc     1200

cagaatcagc tctacaacga gctgaacctg ggaaggagag aggagtacga cgtgctggac     1260

aagcgacgcg gacgcgaccc ggagatgggg gggaaaccac ggcggaaaaa ccctcaggaa     1320

ggactgtaca acgaactcca gaaagacaag atggcggaag cctactcaga aatcgggatg     1380

aagggagagc ggaggagggg aaagggtcac gacgggctgt accagggact gagcaccgcc     1440

actaaggata cctacgatgc cttgcatatg caagcactcc caccccgg                  1488


<210>  98
<211>  496
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LTG 2081 (hScFv aCD123 CD8 TM 4-1BB CD3 zeta)

<400>  98

Met Leu Leu Leu Val Thr Ser Leu Leu Leu Cys Glu Leu Pro His Pro 
1               5                   10                  15      


Ala Phe Leu Leu Ile Pro Glu Val Gln Leu Val Gln Ser Gly Ala Glu 
            20                  25                  30          


Val Lys Lys Pro Gly Ser Ser Val Lys Val Ser Cys Lys Ala Ser Gly 
        35                  40                  45              


Gly Thr Phe Ser Ser Tyr Ala Ile Ser Trp Val Arg Gln Ala Pro Gly 
    50                  55                  60                  


Gln Gly Leu Glu Trp Met Gly Ile Ile Asn Pro Ser Gly Gly Ser Thr 
65                  70                  75                  80  


Ser Tyr Ala Gln Lys Phe Gln Gly Arg Val Thr Met Thr Arg Asp Thr 
                85                  90                  95      


Ser Thr Ser Thr Val Tyr Met Glu Leu Ser Ser Leu Arg Ser Asp Asp 
            100                 105                 110         


Thr Ala Val Tyr Tyr Cys Ala Arg Glu Leu Leu Trp Phe Gly Glu Leu 
        115                 120                 125             


Asp Thr Tyr Gly Met Asp Val Trp Gly Gln Gly Thr Thr Val Thr Val 
    130                 135                 140                 


Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
145                 150                 155                 160 


Ser Leu Pro Val Leu Thr Gln Pro Pro Ser Val Ser Val Ala Pro Gly 
                165                 170                 175     


Lys Thr Ala Arg Ile Thr Cys Gly Gly Asn Asn Ile Gly Ser Lys Ser 
            180                 185                 190         


Val His Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Val Leu Val Ile 
        195                 200                 205             


Tyr Asp Asp Ser Asp Arg Pro Ser Gly Ile Pro Glu Arg Phe Ser Gly 
    210                 215                 220                 


Ser Asn Ser Gly Asn Thr Ala Thr Leu Thr Ile Ser Arg Val Glu Ala 
225                 230                 235                 240 


Gly Asp Glu Ala Asp Tyr Tyr Cys Gln Val Trp Asp Ser Ser Ser Asp 
                245                 250                 255     


His Gly Val Phe Gly Gly Gly Thr Gln Leu Thr Val Leu Gly Ala Ala 
            260                 265                 270         


Ala Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile 
        275                 280                 285             


Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala 
    290                 295                 300                 


Gly Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp Ile Tyr 
305                 310                 315                 320 


Ile Trp Ala Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu Ser Leu 
                325                 330                 335     


Val Ile Thr Leu Tyr Cys Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile 
            340                 345                 350         


Phe Lys Gln Pro Phe Met Arg Pro Val Gln Thr Thr Gln Glu Glu Asp 
        355                 360                 365             


Gly Cys Ser Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu 
    370                 375                 380                 


Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly 
385                 390                 395                 400 


Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr 
                405                 410                 415     


Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys 
            420                 425                 430         


Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys 
        435                 440                 445             


Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg 
    450                 455                 460                 


Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala 
465                 470                 475                 480 


Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
                485                 490                 495     


<210>  99
<211>  1476
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  LTG 2082 (hScFv aCD123 CD8 TM 4-1BB CD3 zeta)

<400>  99
atgctgctgc tggtgaccag cctgctgctg tgcgaactgc cgcatccggc gtttctgctg       60

attccggaag tgcaactcgt ccaatctggt gccgaagtca agaagcctgg ctcaagcgtg      120

aaagtgtcct gcaaagcgtc gggagggacc ttcagctcct acgccatttc ctgggtccgc      180

caagcaccag gacagggcct ggagtggatg ggcggcatca tcccgatctt cgggactgcc      240

aactacgccc agaagttcca ggggagagtg accattaccg ccgacgagtc gaccagcacg      300

gcctacatgg aactgtccag cctgcgctcc gaggacactg ccgtgtacta ctgcgcgagg      360

gccagactcg gtggagcgtt cgacatctgg ggacagggca ccatggtcac cgtgtcatcc      420

ggtggcggag gatccggtgg tggcggatca ggagggggag gatcccagtc cgtgctgact      480

cagcctccct ccgtgagcgc tgcaccggga cagaaggtca ccatctcatg ctcgggggga      540

agctccaaca tcgggaacca ctacgtgtcc tggtaccaac agttgcctgg tgccgctcca      600

aagctgctga tctatgacga taacaagcgg ccgtccggaa tccccgaccg gttctcgggg      660

tctagatccg gaaccagcgc aactctcggc attaccggac tgcagagcgg cgatgaggcc      720

gactactact gtggcacatg ggactcgtcg ctggctgccc acgtgtttgg cactggcacc      780

aaggtcaccg tgcttggagc ggccgcaact accacccctg cccctcggcc gccgactccg      840

gccccaacca tcgcaagcca acccctctcc ttgcgccccg aagcttgccg cccggccgcg      900

ggtggagccg tgcatacccg ggggctggac tttgcctgcg atatctacat ttgggccccg      960

ctggccggca cttgcggcgt gctcctgctg tcgctggtca tcacccttta ctgcaagagg     1020

ggccggaaga agctgcttta catcttcaag cagccgttca tgcggcccgt gcagacgact     1080

caggaagagg acggatgctc gtgcagattc cctgaggagg aagagggggg atgcgaactg     1140

cgcgtcaagt tctcacggtc cgccgacgcc cccgcatatc aacagggcca gaatcagctc     1200

tacaacgagc tgaacctggg aaggagagag gagtacgacg tgctggacaa gcgacgcgga     1260

cgcgacccgg agatgggggg gaaaccacgg cggaaaaacc ctcaggaagg actgtacaac     1320

gaactccaga aagacaagat ggcggaagcc tactcagaaa tcgggatgaa gggagagcgg     1380

aggaggggaa agggtcacga cgggctgtac cagggactga gcaccgccac taaggatacc     1440

tacgatgcct tgcatatgca agcactccca ccccgg                               1476


<210>  100
<211>  492
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LTG 2082 (hScFv aCD123 CD8 TM 4-1BB CD3 zeta)

<400>  100

Met Leu Leu Leu Val Thr Ser Leu Leu Leu Cys Glu Leu Pro His Pro 
1               5                   10                  15      


Ala Phe Leu Leu Ile Pro Glu Val Gln Leu Val Gln Ser Gly Ala Glu 
            20                  25                  30          


Val Lys Lys Pro Gly Ser Ser Val Lys Val Ser Cys Lys Ala Ser Gly 
        35                  40                  45              


Gly Thr Phe Ser Ser Tyr Ala Ile Ser Trp Val Arg Gln Ala Pro Gly 
    50                  55                  60                  


Gln Gly Leu Glu Trp Met Gly Gly Ile Ile Pro Ile Phe Gly Thr Ala 
65                  70                  75                  80  


Asn Tyr Ala Gln Lys Phe Gln Gly Arg Val Thr Ile Thr Ala Asp Glu 
                85                  90                  95      


Ser Thr Ser Thr Ala Tyr Met Glu Leu Ser Ser Leu Arg Ser Glu Asp 
            100                 105                 110         


Thr Ala Val Tyr Tyr Cys Ala Arg Ala Arg Leu Gly Gly Ala Phe Asp 
        115                 120                 125             


Ile Trp Gly Gln Gly Thr Met Val Thr Val Ser Ser Gly Gly Gly Gly 
    130                 135                 140                 


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Ser Val Leu Thr 
145                 150                 155                 160 


Gln Pro Pro Ser Val Ser Ala Ala Pro Gly Gln Lys Val Thr Ile Ser 
                165                 170                 175     


Cys Ser Gly Gly Ser Ser Asn Ile Gly Asn His Tyr Val Ser Trp Tyr 
            180                 185                 190         


Gln Gln Leu Pro Gly Ala Ala Pro Lys Leu Leu Ile Tyr Asp Asp Asn 
        195                 200                 205             


Lys Arg Pro Ser Gly Ile Pro Asp Arg Phe Ser Gly Ser Arg Ser Gly 
    210                 215                 220                 


Thr Ser Ala Thr Leu Gly Ile Thr Gly Leu Gln Ser Gly Asp Glu Ala 
225                 230                 235                 240 


Asp Tyr Tyr Cys Gly Thr Trp Asp Ser Ser Leu Ala Ala His Val Phe 
                245                 250                 255     


Gly Thr Gly Thr Lys Val Thr Val Leu Gly Ala Ala Ala Thr Thr Thr 
            260                 265                 270         


Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro 
        275                 280                 285             


Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala Val 
    290                 295                 300                 


His Thr Arg Gly Leu Asp Phe Ala Cys Asp Ile Tyr Ile Trp Ala Pro 
305                 310                 315                 320 


Leu Ala Gly Thr Cys Gly Val Leu Leu Leu Ser Leu Val Ile Thr Leu 
                325                 330                 335     


Tyr Cys Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro 
            340                 345                 350         


Phe Met Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys 
        355                 360                 365             


Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu Arg Val Lys Phe 
    370                 375                 380                 


Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly Gln Asn Gln Leu 
385                 390                 395                 400 


Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp 
                405                 410                 415     


Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg Arg Lys 
            420                 425                 430         


Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala 
        435                 440                 445             


Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys 
    450                 455                 460                 


Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr 
465                 470                 475                 480 


Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
                485                 490         


<210>  101
<211>  1491
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  LTG 2083 (hScFv aCD123 CD8 TM 4-1BB CD3 zeta)

<400>  101
atgctgctgc tggtgaccag cctgctgctg tgcgaactgc cgcatccggc gtttctgctg       60

attccggaag tgcaacttgt ccagagcgga gccgaagtga agaaacctgg atcctccgtc      120

aaagtgtcgt gcaaggcttc gggcggaacc ttctcctcgt acgcgatctc atgggtcaga      180

caggcacccg gacagggact ggagtggatg ggcggcatca ttcccatctt cggcaccgct      240

aattacgccc agaagtttca ggggagagtg accatcaccg ccgacgagtc cacctccact      300

gcctacatgg aactgtcctc actgaggtcc gaggatactg ccgtgtacta ctgcgcgtcg      360

caaaaggggg gtggatggtc cattgacgcc ttcgatattt ggggacaggg gacgatggtc      420

acagtgtcat ccggcggtgg tggatccggt ggtggcggat ccggaggagg aggcagccag      480

tccgtgctga cccagccgcc tagcgtgtcg gccgcatctg ggcagcgcgt gaccatttcc      540

tgttccgggt cctcgtccaa catcggcaac aactacgcct cctggtacca acagctcccg      600

ggaatggccc ctaagctgct gatctacgag gacaacaagc ggccatccgg gatctcagac      660

cggttcagcg gatcccagtc cggcacttcc gcgagcctcg ccatcaccgg actgcaggct      720

gaggacgaag ccgactacta ctgccaatca tatgacagct cgctcagcgg cgatgtggtg      780

ttcggcggtg gcactaagct gaccgtgttg ggagcggccg caactaccac ccctgcccct      840

cggccgccga ctccggcccc aaccatcgca agccaacccc tctccttgcg ccccgaagct      900

tgccgcccgg ccgcgggtgg agccgtgcat acccgggggc tggactttgc ctgcgatatc      960

tacatttggg ccccgctggc cggcacttgc ggcgtgctcc tgctgtcgct ggtcatcacc     1020

ctttactgca agaggggccg gaagaagctg ctttacatct tcaagcagcc gttcatgcgg     1080

cccgtgcaga cgactcagga agaggacgga tgctcgtgca gattccctga ggaggaagag     1140

gggggatgcg aactgcgcgt caagttctca cggtccgccg acgcccccgc atatcaacag     1200

ggccagaatc agctctacaa cgagctgaac ctgggaagga gagaggagta cgacgtgctg     1260

gacaagcgac gcggacgcga cccggagatg ggggggaaac cacggcggaa aaaccctcag     1320

gaaggactgt acaacgaact ccagaaagac aagatggcgg aagcctactc agaaatcggg     1380

atgaagggag agcggaggag gggaaagggt cacgacgggc tgtaccaggg actgagcacc     1440

gccactaagg atacctacga tgccttgcat atgcaagcac tcccaccccg g              1491


<210>  102
<211>  497
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LTG 2083 (hScFv aCD123 CD8 TM 4-1BB CD3 zeta)

<400>  102

Met Leu Leu Leu Val Thr Ser Leu Leu Leu Cys Glu Leu Pro His Pro 
1               5                   10                  15      


Ala Phe Leu Leu Ile Pro Glu Val Gln Leu Val Gln Ser Gly Ala Glu 
            20                  25                  30          


Val Lys Lys Pro Gly Ser Ser Val Lys Val Ser Cys Lys Ala Ser Gly 
        35                  40                  45              


Gly Thr Phe Ser Ser Tyr Ala Ile Ser Trp Val Arg Gln Ala Pro Gly 
    50                  55                  60                  


Gln Gly Leu Glu Trp Met Gly Gly Ile Ile Pro Ile Phe Gly Thr Ala 
65                  70                  75                  80  


Asn Tyr Ala Gln Lys Phe Gln Gly Arg Val Thr Ile Thr Ala Asp Glu 
                85                  90                  95      


Ser Thr Ser Thr Ala Tyr Met Glu Leu Ser Ser Leu Arg Ser Glu Asp 
            100                 105                 110         


Thr Ala Val Tyr Tyr Cys Ala Ser Gln Lys Gly Gly Gly Trp Ser Ile 
        115                 120                 125             


Asp Ala Phe Asp Ile Trp Gly Gln Gly Thr Met Val Thr Val Ser Ser 
    130                 135                 140                 


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln 
145                 150                 155                 160 


Ser Val Leu Thr Gln Pro Pro Ser Val Ser Ala Ala Ser Gly Gln Arg 
                165                 170                 175     


Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn Tyr 
            180                 185                 190         


Ala Ser Trp Tyr Gln Gln Leu Pro Gly Met Ala Pro Lys Leu Leu Ile 
        195                 200                 205             


Tyr Glu Asp Asn Lys Arg Pro Ser Gly Ile Ser Asp Arg Phe Ser Gly 
    210                 215                 220                 


Ser Gln Ser Gly Thr Ser Ala Ser Leu Ala Ile Thr Gly Leu Gln Ala 
225                 230                 235                 240 


Glu Asp Glu Ala Asp Tyr Tyr Cys Gln Ser Tyr Asp Ser Ser Leu Ser 
                245                 250                 255     


Gly Asp Val Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Ala 
            260                 265                 270         


Ala Ala Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr 
        275                 280                 285             


Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala 
    290                 295                 300                 


Ala Gly Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp Ile 
305                 310                 315                 320 


Tyr Ile Trp Ala Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu Ser 
                325                 330                 335     


Leu Val Ile Thr Leu Tyr Cys Lys Arg Gly Arg Lys Lys Leu Leu Tyr 
            340                 345                 350         


Ile Phe Lys Gln Pro Phe Met Arg Pro Val Gln Thr Thr Gln Glu Glu 
        355                 360                 365             


Asp Gly Cys Ser Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu 
    370                 375                 380                 


Leu Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln 
385                 390                 395                 400 


Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu 
                405                 410                 415     


Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly 
            420                 425                 430         


Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln 
        435                 440                 445             


Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu 
    450                 455                 460                 


Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr 
465                 470                 475                 480 


Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro 
                485                 490                 495     


Arg 
    


<210>  103
<211>  1473
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  LTG 2084 (hScFv aCD123 CD8 TM 4-1BB CD3 zeta)

<400>  103
atgctgctgc tggtgaccag cctgctgctg tgcgaactgc cgcatccggc gtttctgctg       60

attccggaag tccaactcgt ccaaagcggt gcagaagtga aaaagccagg ctcctcagtg      120

aaagtgtcct gcaaagcctc ggggggaacc ttctcctcct acgccatctc ctgggtccgc      180

caagcaccag gacagggcct ggagtggatg ggcgggatca ttccgatctt cggcaccgcc      240

aactacgccc agaagtttca gggccgcgtg actatcaccg ccgacgagtc cacctccact      300

gcgtacatgg aactgtccag cctgcggtcc gaggacactg ccgtgtatta ctgcgcgaga      360

gtcggttgct ccgggggatc gtgttatccc gactactggg gacaggggac cctcgtgacc      420

gtgtcgtcgg gtggtggtgg aagcggcggt ggaggatccg gtggaggagg cagcgaaatc      480

gtgctgactc agtcgccgtc ctcgctttcc gcctccgtgg gagatcgcgt gaccatcacg      540

tgtcaggctt ctcaagacat tagcaactac ctgaattggt accagcagaa gcctggaaag      600

gctccgaagc tgctcatcta cgacgcgtcc aacctggaga caggggtgcc ttcacggttc      660

tcgggaagcg gatccggcac cgatttcacc ttcaccattt caagcctgca acccgaggat      720

attgccacct actactgcca gcagtacgac aacctccccc tgactttcgg gggcggcact      780

aagttggaca tcaaggcggc cgcaactacc acccctgccc ctcggccgcc gactccggcc      840

ccaaccatcg caagccaacc cctctccttg cgccccgaag cttgccgccc ggccgcgggt      900

ggagccgtgc atacccgggg gctggacttt gcctgcgata tctacatttg ggccccgctg      960

gccggcactt gcggcgtgct cctgctgtcg ctggtcatca ccctttactg caagaggggc     1020

cggaagaagc tgctttacat cttcaagcag ccgttcatgc ggcccgtgca gacgactcag     1080

gaagaggacg gatgctcgtg cagattccct gaggaggaag aggggggatg cgaactgcgc     1140

gtcaagttct cacggtccgc cgacgccccc gcatatcaac agggccagaa tcagctctac     1200

aacgagctga acctgggaag gagagaggag tacgacgtgc tggacaagcg acgcggacgc     1260

gacccggaga tgggggggaa accacggcgg aaaaaccctc aggaaggact gtacaacgaa     1320

ctccagaaag acaagatggc ggaagcctac tcagaaatcg ggatgaaggg agagcggagg     1380

aggggaaagg gtcacgacgg gctgtaccag ggactgagca ccgccactaa ggatacctac     1440

gatgccttgc atatgcaagc actcccaccc cgg                                  1473


<210>  104
<211>  491
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LTG 2084 (hScFv aCD123 CD8 TM 4-1BB CD3 zeta)

<400>  104

Met Leu Leu Leu Val Thr Ser Leu Leu Leu Cys Glu Leu Pro His Pro 
1               5                   10                  15      


Ala Phe Leu Leu Ile Pro Glu Val Gln Leu Val Gln Ser Gly Ala Glu 
            20                  25                  30          


Val Lys Lys Pro Gly Ser Ser Val Lys Val Ser Cys Lys Ala Ser Gly 
        35                  40                  45              


Gly Thr Phe Ser Ser Tyr Ala Ile Ser Trp Val Arg Gln Ala Pro Gly 
    50                  55                  60                  


Gln Gly Leu Glu Trp Met Gly Gly Ile Ile Pro Ile Phe Gly Thr Ala 
65                  70                  75                  80  


Asn Tyr Ala Gln Lys Phe Gln Gly Arg Val Thr Ile Thr Ala Asp Glu 
                85                  90                  95      


Ser Thr Ser Thr Ala Tyr Met Glu Leu Ser Ser Leu Arg Ser Glu Asp 
            100                 105                 110         


Thr Ala Val Tyr Tyr Cys Ala Arg Val Gly Cys Ser Gly Gly Ser Cys 
        115                 120                 125             


Tyr Pro Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly 
    130                 135                 140                 


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Ile 
145                 150                 155                 160 


Val Leu Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg 
                165                 170                 175     


Val Thr Ile Thr Cys Gln Ala Ser Gln Asp Ile Ser Asn Tyr Leu Asn 
            180                 185                 190         


Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr Asp 
        195                 200                 205             


Ala Ser Asn Leu Glu Thr Gly Val Pro Ser Arg Phe Ser Gly Ser Gly 
    210                 215                 220                 


Ser Gly Thr Asp Phe Thr Phe Thr Ile Ser Ser Leu Gln Pro Glu Asp 
225                 230                 235                 240 


Ile Ala Thr Tyr Tyr Cys Gln Gln Tyr Asp Asn Leu Pro Leu Thr Phe 
                245                 250                 255     


Gly Gly Gly Thr Lys Leu Asp Ile Lys Ala Ala Ala Thr Thr Thr Pro 
            260                 265                 270         


Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu 
        275                 280                 285             


Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala Val His 
    290                 295                 300                 


Thr Arg Gly Leu Asp Phe Ala Cys Asp Ile Tyr Ile Trp Ala Pro Leu 
305                 310                 315                 320 


Ala Gly Thr Cys Gly Val Leu Leu Leu Ser Leu Val Ile Thr Leu Tyr 
                325                 330                 335     


Cys Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe 
            340                 345                 350         


Met Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg 
        355                 360                 365             


Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu Arg Val Lys Phe Ser 
    370                 375                 380                 


Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly Gln Asn Gln Leu Tyr 
385                 390                 395                 400 


Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys 
                405                 410                 415     


Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg Arg Lys Asn 
            420                 425                 430         


Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu 
        435                 440                 445             


Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly 
    450                 455                 460                 


His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr 
465                 470                 475                 480 


Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
                485                 490     


<210>  105
<211>  1479
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  LTG 2085 (hScFv aCD123 CD8 TM 4-1BB CD3 zeta)

<400>  105
atgctgctgc tggtgaccag cctgctgctg tgcgaactgc cgcatccggc gtttctgctg       60

attccgcaag tccagttgca acaatgggga gcaggccttc tgaaaccgtc cgagacactg      120

agcctgacgt gcgccgtcta tggcggatcg ttctccggat actactggtc gtggatcaga      180

cagcctccgg gaaagggtct ggaatggatc ggcgaaatca accacagcgg cagcaccaat      240

tacaacccgt cactgaagtc aagggtcacc attagcgtgg acacttccaa gaaccagttc      300

tccctgaaac tgtcgagcgt gaccgctgcc gatactgccg tgtactactg tgcccgcggc      360

caagtcaagt atagctcaag cctcggctac tggggccagg gaaccctcgt gaccgtgtcc      420

tcgggtggag gaggctccgg tggtggagga tccggtggcg gaggatcgca gtccgtgctg      480

acccagcctc cctccgtgtc tgctgcccct gggcaaaagg tcaccatttc gtgctccggc      540

tcatcgtcca acatcgggaa caactttgtg tcctggtacc agcagctgcc cggtactgcc      600

ccaaagctgc tgatctacga ggacaacaag cgcccatccg ggattccgga tcggttcagc      660

ggatcacggt ccggaactag cgcgaccctg gggatcaccg ggctccagac tggcgacgaa      720

gcggactact actgcggaac ttgggactcc tccttggggg cctgggtgtt cggcggaggg      780

accaagctca ccgtgcttgg agcggccgca actaccaccc ctgcccctcg gccgccgact      840

ccggccccaa ccatcgcaag ccaacccctc tccttgcgcc ccgaagcttg ccgcccggcc      900

gcgggtggag ccgtgcatac ccgggggctg gactttgcct gcgatatcta catttgggcc      960

ccgctggccg gcacttgcgg cgtgctcctg ctgtcgctgg tcatcaccct ttactgcaag     1020

aggggccgga agaagctgct ttacatcttc aagcagccgt tcatgcggcc cgtgcagacg     1080

actcaggaag aggacggatg ctcgtgcaga ttccctgagg aggaagaggg gggatgcgaa     1140

ctgcgcgtca agttctcacg gtccgccgac gcccccgcat atcaacaggg ccagaatcag     1200

ctctacaacg agctgaacct gggaaggaga gaggagtacg acgtgctgga caagcgacgc     1260

ggacgcgacc cggagatggg ggggaaacca cggcggaaaa accctcagga aggactgtac     1320

aacgaactcc agaaagacaa gatggcggaa gcctactcag aaatcgggat gaagggagag     1380

cggaggaggg gaaagggtca cgacgggctg taccagggac tgagcaccgc cactaaggat     1440

acctacgatg ccttgcatat gcaagcactc ccaccccgg                            1479


<210>  106
<211>  493
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LTG 2085 (hScFv aCD123 CD8 TM 4-1BB CD3 zeta)

<400>  106

Met Leu Leu Leu Val Thr Ser Leu Leu Leu Cys Glu Leu Pro His Pro 
1               5                   10                  15      


Ala Phe Leu Leu Ile Pro Gln Val Gln Leu Gln Gln Trp Gly Ala Gly 
            20                  25                  30          


Leu Leu Lys Pro Ser Glu Thr Leu Ser Leu Thr Cys Ala Val Tyr Gly 
        35                  40                  45              


Gly Ser Phe Ser Gly Tyr Tyr Trp Ser Trp Ile Arg Gln Pro Pro Gly 
    50                  55                  60                  


Lys Gly Leu Glu Trp Ile Gly Glu Ile Asn His Ser Gly Ser Thr Asn 
65                  70                  75                  80  


Tyr Asn Pro Ser Leu Lys Ser Arg Val Thr Ile Ser Val Asp Thr Ser 
                85                  90                  95      


Lys Asn Gln Phe Ser Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr 
            100                 105                 110         


Ala Val Tyr Tyr Cys Ala Arg Gly Gln Val Lys Tyr Ser Ser Ser Leu 
        115                 120                 125             


Gly Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly 
    130                 135                 140                 


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Ser Val Leu 
145                 150                 155                 160 


Thr Gln Pro Pro Ser Val Ser Ala Ala Pro Gly Gln Lys Val Thr Ile 
                165                 170                 175     


Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn Phe Val Ser Trp 
            180                 185                 190         


Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu Ile Tyr Glu Asp 
        195                 200                 205             


Asn Lys Arg Pro Ser Gly Ile Pro Asp Arg Phe Ser Gly Ser Arg Ser 
    210                 215                 220                 


Gly Thr Ser Ala Thr Leu Gly Ile Thr Gly Leu Gln Thr Gly Asp Glu 
225                 230                 235                 240 


Ala Asp Tyr Tyr Cys Gly Thr Trp Asp Ser Ser Leu Gly Ala Trp Val 
                245                 250                 255     


Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Ala Ala Ala Thr Thr 
            260                 265                 270         


Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln 
        275                 280                 285             


Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala 
    290                 295                 300                 


Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp Ile Tyr Ile Trp Ala 
305                 310                 315                 320 


Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu Ser Leu Val Ile Thr 
                325                 330                 335     


Leu Tyr Cys Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln 
            340                 345                 350         


Pro Phe Met Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser 
        355                 360                 365             


Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu Arg Val Lys 
    370                 375                 380                 


Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly Gln Asn Gln 
385                 390                 395                 400 


Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu 
                405                 410                 415     


Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg Arg 
            420                 425                 430         


Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met 
        435                 440                 445             


Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly 
    450                 455                 460                 


Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp 
465                 470                 475                 480 


Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
                485                 490             


<210>  107
<211>  1461
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  LTG 2086 (hScFv aCD123 CD8 TM 4-1BB CD3 zeta)

<400>  107
atgctgctgc tggtgaccag cctgctgctg tgcgaactgc cgcatccggc gtttctgctg       60

attccggaag tgcagttggt ggagagcggt ggaggacttg tgcaacctgg tggatccctg      120

agattgtcgt gcgcagcttc agggttcacc ttctcctcct acgccatgca ctgggtccgc      180

caagcaccag gaaagggcct ggaatgggtc agctccatct cctcgtcgtc ctcgtacatc      240

tactatgccg actccgtgaa gggccgcttc accattagcc gggacaactc aaagaacact      300

ctgtaccttc aaatgaactc cctgcgggct gaagataccg ccgtgtacta ctgcgcgagg      360

gattgggatg acgcgttcga catttggggc caggggacta ccgtcaccgt gtcgtcgggt      420

ggaggaggat ccgggggtgg aggatcggga gggggtggaa gcgacattca gatgactcag      480

agcccgtcct ccctgtcggc ctcagtgggc gacagagtga ccatcacctg tcaagccagc      540

caggacatct caaactacct gaactggtac cagcagaagc ccggaaaggc ccctaagctg      600

ctcatctacg acgcctccaa cctggagact ggagtgccct cacggttttc cggctctgga      660

agcggcaccg atttcacctt cacgatctcc tccctgcaac cggaagatat cgcgacctac      720

tactgccagc agtatgacaa tctcccgctc accttcggtg gcggcactaa gctcgagatc      780

aaagcggccg caactaccac ccctgcccct cggccgccga ctccggcccc aaccatcgca      840

agccaacccc tctccttgcg ccccgaagct tgccgcccgg ccgcgggtgg agccgtgcat      900

acccgggggc tggactttgc ctgcgatatc tacatttggg ccccgctggc cggcacttgc      960

ggcgtgctcc tgctgtcgct ggtcatcacc ctttactgca agaggggccg gaagaagctg     1020

ctttacatct tcaagcagcc gttcatgcgg cccgtgcaga cgactcagga agaggacgga     1080

tgctcgtgca gattccctga ggaggaagag gggggatgcg aactgcgcgt caagttctca     1140

cggtccgccg acgcccccgc atatcaacag ggccagaatc agctctacaa cgagctgaac     1200

ctgggaagga gagaggagta cgacgtgctg gacaagcgac gcggacgcga cccggagatg     1260

ggggggaaac cacggcggaa aaaccctcag gaaggactgt acaacgaact ccagaaagac     1320

aagatggcgg aagcctactc agaaatcggg atgaagggag agcggaggag gggaaagggt     1380

cacgacgggc tgtaccaggg actgagcacc gccactaagg atacctacga tgccttgcat     1440

atgcaagcac tcccaccccg g                                               1461


<210>  108
<211>  487
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LTG 2086 (hScFv aCD123 CD8 TM 4-1BB CD3 zeta)

<400>  108

Met Leu Leu Leu Val Thr Ser Leu Leu Leu Cys Glu Leu Pro His Pro 
1               5                   10                  15      


Ala Phe Leu Leu Ile Pro Glu Val Gln Leu Val Glu Ser Gly Gly Gly 
            20                  25                  30          


Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly 
        35                  40                  45              


Phe Thr Phe Ser Ser Tyr Ala Met His Trp Val Arg Gln Ala Pro Gly 
    50                  55                  60                  


Lys Gly Leu Glu Trp Val Ser Ser Ile Ser Ser Ser Ser Ser Tyr Ile 
65                  70                  75                  80  


Tyr Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn 
                85                  90                  95      


Ser Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp 
            100                 105                 110         


Thr Ala Val Tyr Tyr Cys Ala Arg Asp Trp Asp Asp Ala Phe Asp Ile 
        115                 120                 125             


Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser Gly Gly Gly Gly Ser 
    130                 135                 140                 


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Gln Met Thr Gln 
145                 150                 155                 160 


Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr 
                165                 170                 175     


Cys Gln Ala Ser Gln Asp Ile Ser Asn Tyr Leu Asn Trp Tyr Gln Gln 
            180                 185                 190         


Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr Asp Ala Ser Asn Leu 
        195                 200                 205             


Glu Thr Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp 
    210                 215                 220                 


Phe Thr Phe Thr Ile Ser Ser Leu Gln Pro Glu Asp Ile Ala Thr Tyr 
225                 230                 235                 240 


Tyr Cys Gln Gln Tyr Asp Asn Leu Pro Leu Thr Phe Gly Gly Gly Thr 
                245                 250                 255     


Lys Leu Glu Ile Lys Ala Ala Ala Thr Thr Thr Pro Ala Pro Arg Pro 
            260                 265                 270         


Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro 
        275                 280                 285             


Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala Val His Thr Arg Gly Leu 
    290                 295                 300                 


Asp Phe Ala Cys Asp Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr Cys 
305                 310                 315                 320 


Gly Val Leu Leu Leu Ser Leu Val Ile Thr Leu Tyr Cys Lys Arg Gly 
                325                 330                 335     


Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met Arg Pro Val 
            340                 345                 350         


Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe Pro Glu Glu 
        355                 360                 365             


Glu Glu Gly Gly Cys Glu Leu Arg Val Lys Phe Ser Arg Ser Ala Asp 
    370                 375                 380                 


Ala Pro Ala Tyr Gln Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn 
385                 390                 395                 400 


Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg 
                405                 410                 415     


Asp Pro Glu Met Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly 
            420                 425                 430         


Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu 
        435                 440                 445             


Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu 
    450                 455                 460                 


Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His 
465                 470                 475                 480 


Met Gln Ala Leu Pro Pro Arg 
                485         


<210>  109
<211>  1467
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  LTG 2087 (hScFv aCD123 CD8 TM 4-1BB CD3 zeta)

<400>  109
atgctgctgc tggtgaccag cctgctgctg tgcgaactgc cgcatccggc gtttctgctg       60

attccgcaag tccaactcgt cgaaactggt ggtggcctcg tgaagcctgg aggatccctg      120

cgcctttcct gtgccgcttc cggctttact ttctcgtcgt actccatgaa ctgggtcaga      180

caggctcccg gaaagggcct ggaatgggtg tcctccatct cgtcctcatc ctcctacatc      240

tattacgcgg actccgtgaa gggcagattc accatttccc gggacaacgc caagaacagc      300

ttgtacctcc aaatgaactc cctgcgggca gaggacaccg ccgtgtacta ctgcgcgagg      360

gatggggatt tctggagcgg agccatcgac tactggggcc agggaactct cgtgaccgtc      420

agctccggtg gtggtggaag cggaggcgga ggttctgggg ggggaggatc agacattcag      480

ctgacccagt cgccatcctc cctgagcgcc tcagtggggg accgcgtgac tattacatgc      540

caggcctccc aagatatctc gaactacctg aactggtatc agcagaagcc tggaaaggcc      600

ccgaagctgt tgatctacga tgccagcaac ctggagactg gggtgccttc ccggttctcg      660

ggatcaggct cgggcaccga tttcaccttc acgatcagca gcctgcagcc cgaggacatt      720

gcaacctact actgccagca gtacgacaat ctgccgcttt ttgggggagg caccaagctg      780

gaaatcaaag cggccgcaac taccacccct gcccctcggc cgccgactcc ggccccaacc      840

atcgcaagcc aacccctctc cttgcgcccc gaagcttgcc gcccggccgc gggtggagcc      900

gtgcataccc gggggctgga ctttgcctgc gatatctaca tttgggcccc gctggccggc      960

acttgcggcg tgctcctgct gtcgctggtc atcacccttt actgcaagag gggccggaag     1020

aagctgcttt acatcttcaa gcagccgttc atgcggcccg tgcagacgac tcaggaagag     1080

gacggatgct cgtgcagatt ccctgaggag gaagaggggg gatgcgaact gcgcgtcaag     1140

ttctcacggt ccgccgacgc ccccgcatat caacagggcc agaatcagct ctacaacgag     1200

ctgaacctgg gaaggagaga ggagtacgac gtgctggaca agcgacgcgg acgcgacccg     1260

gagatggggg ggaaaccacg gcggaaaaac cctcaggaag gactgtacaa cgaactccag     1320

aaagacaaga tggcggaagc ctactcagaa atcgggatga agggagagcg gaggagggga     1380

aagggtcacg acgggctgta ccagggactg agcaccgcca ctaaggatac ctacgatgcc     1440

ttgcatatgc aagcactccc accccgg                                         1467


<210>  110
<211>  489
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LTG 2087 (hScFv aCD123 CD8 TM 4-1BB CD3 zeta)

<400>  110

Met Leu Leu Leu Val Thr Ser Leu Leu Leu Cys Glu Leu Pro His Pro 
1               5                   10                  15      


Ala Phe Leu Leu Ile Pro Gln Val Gln Leu Val Glu Thr Gly Gly Gly 
            20                  25                  30          


Leu Val Lys Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly 
        35                  40                  45              


Phe Thr Phe Ser Ser Tyr Ser Met Asn Trp Val Arg Gln Ala Pro Gly 
    50                  55                  60                  


Lys Gly Leu Glu Trp Val Ser Ser Ile Ser Ser Ser Ser Ser Tyr Ile 
65                  70                  75                  80  


Tyr Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn 
                85                  90                  95      


Ala Lys Asn Ser Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp 
            100                 105                 110         


Thr Ala Val Tyr Tyr Cys Ala Arg Asp Gly Asp Phe Trp Ser Gly Ala 
        115                 120                 125             


Ile Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly 
    130                 135                 140                 


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Gln 
145                 150                 155                 160 


Leu Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val 
                165                 170                 175     


Thr Ile Thr Cys Gln Ala Ser Gln Asp Ile Ser Asn Tyr Leu Asn Trp 
            180                 185                 190         


Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr Asp Ala 
        195                 200                 205             


Ser Asn Leu Glu Thr Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser 
    210                 215                 220                 


Gly Thr Asp Phe Thr Phe Thr Ile Ser Ser Leu Gln Pro Glu Asp Ile 
225                 230                 235                 240 


Ala Thr Tyr Tyr Cys Gln Gln Tyr Asp Asn Leu Pro Leu Phe Gly Gly 
                245                 250                 255     


Gly Thr Lys Leu Glu Ile Lys Ala Ala Ala Thr Thr Thr Pro Ala Pro 
            260                 265                 270         


Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu 
        275                 280                 285             


Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala Val His Thr Arg 
    290                 295                 300                 


Gly Leu Asp Phe Ala Cys Asp Ile Tyr Ile Trp Ala Pro Leu Ala Gly 
305                 310                 315                 320 


Thr Cys Gly Val Leu Leu Leu Ser Leu Val Ile Thr Leu Tyr Cys Lys 
                325                 330                 335     


Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met Arg 
            340                 345                 350         


Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe Pro 
        355                 360                 365             


Glu Glu Glu Glu Gly Gly Cys Glu Leu Arg Val Lys Phe Ser Arg Ser 
    370                 375                 380                 


Ala Asp Ala Pro Ala Tyr Gln Gln Gly Gln Asn Gln Leu Tyr Asn Glu 
385                 390                 395                 400 


Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg 
                405                 410                 415     


Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln 
            420                 425                 430         


Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr 
        435                 440                 445             


Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp 
    450                 455                 460                 


Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala 
465                 470                 475                 480 


Leu His Met Gln Ala Leu Pro Pro Arg 
                485                 


<210>  111
<211>  1467
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  LTG 2088 (hScFv aCD123 CD8 TM 4-1BB CD3 zeta)

<400>  111
atgctgctgc tggtgaccag cctgctgctg tgcgaactgc cgcatccggc gtttctgctg       60

attccggagg tgcaattggt gcagtcaggt ggtggagtgg tgcagccagg aagatccctt      120

agactctcgt gtgcggcgtc aggctttacc ttctcctcgt actccatgaa ctgggtcaga      180

caggcaccgg gaaagggact ggaatgggtg tcctccatct cgtcctcctc ctcctacatc      240

tactacgccg atagcgtgaa gggccggttc accatttcgc gcgacaacgc caagaacacc      300

ctgtacctcc aaatgaattc gctgcgggcc gaagataccg ctgtctatta ctgcgcccgc      360

gacaactggg gctcgctgga ctattggggc cagggaaccc tcgtcaccgt gtcaagcgga      420

gggggtggat ccggaggcgg aggatccggt ggagggggaa gcgacattca gatgactcag      480

agcccgtcct ccctgtctgc ctccgtgggg gatcgcgtga ccatcacatg ccaggcctca      540

caagacatca gcaattacct gaactggtac cagcagaagc ctggaaaggc ccccaagctg      600

ctgatctacg atgccagcaa cctggagact ggggtgcctt caaggttctc cggttccgga      660

agcggcactg acttcacctt cactatctcg agcctgcaac ccgaggacat tgccacctac      720

tactgccagc agtacgacaa ccttccgcac atgtacacgt tcggccaggg caccaagctc      780

gaaatcaaag cggccgcaac taccacccct gcccctcggc cgccgactcc ggccccaacc      840

atcgcaagcc aacccctctc cttgcgcccc gaagcttgcc gcccggccgc gggtggagcc      900

gtgcataccc gggggctgga ctttgcctgc gatatctaca tttgggcccc gctggccggc      960

acttgcggcg tgctcctgct gtcgctggtc atcacccttt actgcaagag gggccggaag     1020

aagctgcttt acatcttcaa gcagccgttc atgcggcccg tgcagacgac tcaggaagag     1080

gacggatgct cgtgcagatt ccctgaggag gaagaggggg gatgcgaact gcgcgtcaag     1140

ttctcacggt ccgccgacgc ccccgcatat caacagggcc agaatcagct ctacaacgag     1200

ctgaacctgg gaaggagaga ggagtacgac gtgctggaca agcgacgcgg acgcgacccg     1260

gagatggggg ggaaaccacg gcggaaaaac cctcaggaag gactgtacaa cgaactccag     1320

aaagacaaga tggcggaagc ctactcagaa atcgggatga agggagagcg gaggagggga     1380

aagggtcacg acgggctgta ccagggactg agcaccgcca ctaaggatac ctacgatgcc     1440

ttgcatatgc aagcactccc accccgg                                         1467


<210>  112
<211>  489
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LTG 2088 (hScFv aCD123 CD8 TM 4-1BB CD3 zeta)

<400>  112

Met Leu Leu Leu Val Thr Ser Leu Leu Leu Cys Glu Leu Pro His Pro 
1               5                   10                  15      


Ala Phe Leu Leu Ile Pro Glu Val Gln Leu Val Gln Ser Gly Gly Gly 
            20                  25                  30          


Val Val Gln Pro Gly Arg Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly 
        35                  40                  45              


Phe Thr Phe Ser Ser Tyr Ser Met Asn Trp Val Arg Gln Ala Pro Gly 
    50                  55                  60                  


Lys Gly Leu Glu Trp Val Ser Ser Ile Ser Ser Ser Ser Ser Tyr Ile 
65                  70                  75                  80  


Tyr Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn 
                85                  90                  95      


Ala Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp 
            100                 105                 110         


Thr Ala Val Tyr Tyr Cys Ala Arg Asp Asn Trp Gly Ser Leu Asp Tyr 
        115                 120                 125             


Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser 
    130                 135                 140                 


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Gln Met Thr Gln 
145                 150                 155                 160 


Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr 
                165                 170                 175     


Cys Gln Ala Ser Gln Asp Ile Ser Asn Tyr Leu Asn Trp Tyr Gln Gln 
            180                 185                 190         


Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr Asp Ala Ser Asn Leu 
        195                 200                 205             


Glu Thr Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp 
    210                 215                 220                 


Phe Thr Phe Thr Ile Ser Ser Leu Gln Pro Glu Asp Ile Ala Thr Tyr 
225                 230                 235                 240 


Tyr Cys Gln Gln Tyr Asp Asn Leu Pro His Met Tyr Thr Phe Gly Gln 
                245                 250                 255     


Gly Thr Lys Leu Glu Ile Lys Ala Ala Ala Thr Thr Thr Pro Ala Pro 
            260                 265                 270         


Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu 
        275                 280                 285             


Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala Val His Thr Arg 
    290                 295                 300                 


Gly Leu Asp Phe Ala Cys Asp Ile Tyr Ile Trp Ala Pro Leu Ala Gly 
305                 310                 315                 320 


Thr Cys Gly Val Leu Leu Leu Ser Leu Val Ile Thr Leu Tyr Cys Lys 
                325                 330                 335     


Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met Arg 
            340                 345                 350         


Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe Pro 
        355                 360                 365             


Glu Glu Glu Glu Gly Gly Cys Glu Leu Arg Val Lys Phe Ser Arg Ser 
    370                 375                 380                 


Ala Asp Ala Pro Ala Tyr Gln Gln Gly Gln Asn Gln Leu Tyr Asn Glu 
385                 390                 395                 400 


Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg 
                405                 410                 415     


Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln 
            420                 425                 430         


Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr 
        435                 440                 445             


Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp 
    450                 455                 460                 


Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala 
465                 470                 475                 480 


Leu His Met Gln Ala Leu Pro Pro Arg 
                485                 


