                         SEQUENCE LISTING

<110>  Ĵײ̩ҽҩɷ޹˾
 
<120>  -1PD-L1Ŀ;

<130>  IEC180174PCT


<160>  20    

<170>  PatentIn version 3.2

<210>  1
<211>  360
<212>  DNA
<213>  Artificial

<220>
<223>  뵥5C10ɱĺ

<400>  1
caggtgcaac tgaaggagtc aggacctggc ctggtggcgc cctcacagaa cctgtccatt     60

acctgcactg tctctgggtt ctcattaagc aactatgata taagctggat tcgccagcca    120

ccaggaaagg gtctggagtg gctcggagta atatggactg gtggagccac aaattataat    180

tcagctttca tgtccagact gagcatcagt agggacaact ccaagagcca agttttctta    240

aaaatgaaca gtctgcaaac tgatgacaca gccatatatt actgtgtgag agattcgaac    300

tataggtacg acgagccgtt tacttactgg ggccaaggga ctctggtcac tgtctctgca    360


<210>  2
<211>  120
<212>  PRT
<213>  Artificial

<220>
<223>  5C10ɱİ

<400>  2

Gln Val Gln Leu Lys Glu Ser Gly Pro Gly Leu Val Ala Pro Ser Gln 
1               5                   10                  15      


Asn Leu Ser Ile Thr Cys Thr Val Ser Gly Phe Ser Leu Ser Asn Tyr 
            20                  25                  30          


Asp Ile Ser Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Leu 
        35                  40                  45              


Gly Val Ile Trp Thr Gly Gly Ala Thr Asn Tyr Asn Ser Ala Phe Met 
    50                  55                  60                  


Ser Arg Leu Ser Ile Ser Arg Asp Asn Ser Lys Ser Gln Val Phe Leu 
65                  70                  75                  80  


Lys Met Asn Ser Leu Gln Thr Asp Asp Thr Ala Ile Tyr Tyr Cys Val 
                85                  90                  95      


Arg Asp Ser Asn Tyr Arg Tyr Asp Glu Pro Phe Thr Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ala 
        115                 120 


<210>  3
<211>  318
<212>  DNA
<213>  Artificial

<220>
<223>  뵥5C10ɱĺ

<400>  3
gacatcttgc tgactcagtc tccagccatc ctgtctgtga gtccaggaga aagagtcagt     60

ctctcctgca gggccagtca gagcattggc acaaacatac actggtttca gcaaagaaca    120

aatggttctc caaggcttct cataaagtat gcttctgagt ctatctctgg gatcccttcc    180

aggtttagtg gcagtggatc agggacagat tttactctta gcatcaacag tgtggagtct    240

gaagatattg cagattacta ctgtcaacaa agtaatagct ggccgtacac gttcggaggg    300

gggaccaagc tggaaata                                                  318


<210>  4
<211>  106
<212>  PRT
<213>  Artificial

<220>
<223>  5C10ɱİ

<400>  4

Asp Ile Leu Leu Thr Gln Ser Pro Ala Ile Leu Ser Val Ser Pro Gly 
1               5                   10                  15      


Glu Arg Val Ser Leu Ser Cys Arg Ala Ser Gln Ser Ile Gly Thr Asn 
            20                  25                  30          


Ile His Trp Phe Gln Gln Arg Thr Asn Gly Ser Pro Arg Leu Leu Ile 
        35                  40                  45              


Lys Tyr Ala Ser Glu Ser Ile Ser Gly Ile Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Ser Ile Asn Ser Val Glu Ser 
65                  70                  75                  80  


Glu Asp Ile Ala Asp Tyr Tyr Cys Gln Gln Ser Asn Ser Trp Pro Tyr 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile 
            100                 105     


<210>  5
<211>  360
<212>  DNA
<213>  Artificial

<220>
<223>  5C10H1L1ɱĺ

<400>  5
caggtccagc tgcaggagtc aggccccggc ctggtgaagc ccagtgagaa cctgtcaatc     60

acctgcacag tctctggctt ctcactgagc aattacgaca tcagttggat tcgacagccc    120

cctggaaagg gcctggaatg gctgggcgtg atctggacag gcggggcaac taactataat    180

ccagccttta aaagccggct gaccatttcc agagacaact ccaagtctca ggtgtctctg    240

aaaatgagct ccctgcaggc cgctgatacc gctgtgtact attgtgtcag ggacagcaat    300

taccgctatg atgagccctt cacatactgg gggcagggaa ctctggtgac cgtctctagt    360


<210>  6
<211>  120
<212>  PRT
<213>  Artificial

<220>
<223>  5C10H1L1ɱİ

<400>  6

Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 
1               5                   10                  15      


Asn Leu Ser Ile Thr Cys Thr Val Ser Gly Phe Ser Leu Ser Asn Tyr 
            20                  25                  30          


Asp Ile Ser Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Leu 
        35                  40                  45              


Gly Val Ile Trp Thr Gly Gly Ala Thr Asn Tyr Asn Pro Ala Phe Lys 
    50                  55                  60                  


Ser Arg Leu Thr Ile Ser Arg Asp Asn Ser Lys Ser Gln Val Ser Leu 
65                  70                  75                  80  


Lys Met Ser Ser Leu Gln Ala Ala Asp Thr Ala Val Tyr Tyr Cys Val 
                85                  90                  95      


Arg Asp Ser Asn Tyr Arg Tyr Asp Glu Pro Phe Thr Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser 
        115                 120 


<210>  7
<211>  321
<212>  DNA
<213>  Artificial

<220>
<223>  5C10H1L1ɱĺ

<400>  7
gaaatcgtgc tgacacagag ccctgacaca ctgagcgtga ctcccaagga gaaagtcacc     60

ctgacatgcc gggcatcaca gagcatcgga acaaacattc actggttcca gcagagacca    120

ggccagagcc ccaagctgct gatcaaatac gcctccgaat ctatcagtgg cattccttcc    180

cgattctcag gcagcgggtc cggaaccgac tttactctga ccattaactc tgtggaggct    240

gaagatgccg ctacatacta ttgccagcag tctaatagtt ggccttatac cttcggccag    300

gggacaaagc tggagatcaa a                                              321


<210>  8
<211>  107
<212>  PRT
<213>  Artificial

<220>
<223>  5C10H1L1ɱİ

<400>  8

Glu Ile Val Leu Thr Gln Ser Pro Asp Thr Leu Ser Val Thr Pro Lys 
1               5                   10                  15      


Glu Lys Val Thr Leu Thr Cys Arg Ala Ser Gln Ser Ile Gly Thr Asn 
            20                  25                  30          


Ile His Trp Phe Gln Gln Arg Pro Gly Gln Ser Pro Lys Leu Leu Ile 
        35                  40                  45              


Lys Tyr Ala Ser Glu Ser Ile Ser Gly Ile Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Asn Ser Val Glu Ala 
65                  70                  75                  80  


Glu Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Ser Asn Ser Trp Pro Tyr 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105         


<210>  9
<211>  360
<212>  DNA
<213>  Artificial

<220>
<223>  5C10H2L2ɱĺ

<400>  9
caggtccagc tgcaggagtc cggccccggc ctggtgaagc cctccgagac actgtctatc     60

acctgcacag tcagcggctt ctcactgagc aactacgaca tctcctggat tcgacagccc    120

cctggaaagg gcctggaatg gctgggcgtg atctggacag gcggggcaac taactataat    180

ccagccctga aatctcggct gactattagt agagacaact caaagaatca ggtgtccctg    240

aaaatgagct ccgtcaccgc cgctgataca gctgtgtact attgtgtcag ggacagcaat    300

taccgctatg atgagccctt tacctactgg gggcagggaa ctctggtgac cgtctctagt    360


<210>  10
<211>  120
<212>  PRT
<213>  Artificial

<220>
<223>  5C10H2L2ɱİ

<400>  10

Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 
1               5                   10                  15      


Thr Leu Ser Ile Thr Cys Thr Val Ser Gly Phe Ser Leu Ser Asn Tyr 
            20                  25                  30          


Asp Ile Ser Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Leu 
        35                  40                  45              


Gly Val Ile Trp Thr Gly Gly Ala Thr Asn Tyr Asn Pro Ala Leu Lys 
    50                  55                  60                  


Ser Arg Leu Thr Ile Ser Arg Asp Asn Ser Lys Asn Gln Val Ser Leu 
65                  70                  75                  80  


Lys Met Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Val 
                85                  90                  95      


Arg Asp Ser Asn Tyr Arg Tyr Asp Glu Pro Phe Thr Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser 
        115                 120 


<210>  11
<211>  321
<212>  DNA
<213>  Artificial

<220>
<223>  5C10H2L2ɱĺ

<400>  11
gaaatcgtgc tgacacagtc tcctgatacc ctgagcgtga ctcccaagga gaaagtcacc     60

ctgacatgca gggcatcaca gagcatcgga acaaacattc actggttcca gcagaagcca    120

ggccagagcc ccaagctgct gatcaaatac gcctccgaat ctattagtgg agtgccttcc    180

cgcttctcag gcagcgggtc cggaaccgac tttactctga ccatcaactc tgtggaggct    240

gaagatgccg ctacatacta ttgccagcag tctaatagtt ggccttatac cttcggccag    300

gggacaaagc tggagatcaa a                                              321


<210>  12
<211>  107
<212>  PRT
<213>  Artificial

<220>
<223>  5C10H2L2ɱİ

<400>  12

Glu Ile Val Leu Thr Gln Ser Pro Asp Thr Leu Ser Val Thr Pro Lys 
1               5                   10                  15      


Glu Lys Val Thr Leu Thr Cys Arg Ala Ser Gln Ser Ile Gly Thr Asn 
            20                  25                  30          


Ile His Trp Phe Gln Gln Lys Pro Gly Gln Ser Pro Lys Leu Leu Ile 
        35                  40                  45              


Lys Tyr Ala Ser Glu Ser Ile Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Asn Ser Val Glu Ala 
65                  70                  75                  80  


Glu Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Ser Asn Ser Trp Pro Tyr 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105         


<210>  13
<211>  870
<212>  DNA
<213>  Artificial

<220>
<223>  PD-L1Ļ

<400>  13
atgaggattt tcgccgtctt tatctttatg acctactggc atctgctgaa cgcttttact     60

gtgaccgtcc ccaaggatct gtatgtggtg gagtacggaa gcaacatgac tatcgagtgc    120

aagttccccg tggaaaaaca gctggacctg gccgctctga ttgtctattg ggagatggaa    180

gataagaata tcattcagtt tgtgcacggc gaggaagacc tgaaagtcca gcatagctcc    240

tacaggcagc gcgcccgact gctgaaggat cagctgtccc tggggaacgc agccctgcag    300

atcaccgacg tgaaactgca ggatgctgga gtctacaggt gcatgatctc ttacggcggg    360

gctgattata agcgcattac agtgaaagtc aatgcacctt ataacaagat caatcagaga    420

attctggtgg tcgacccagt gaccagtgag cacgaactga catgtcaggc tgagggctac    480

cccaaggcag aagtgatctg gacctctagt gatcatcagg tcctgtcagg gaaaaccaca    540

actaccaaca gcaagcgaga ggaaaaactg ttcaatgtga catccactct gaggatcaac    600

acaactacca atgagatttt ctattgcact tttcggagac tggaccctga ggaaaaccac    660

accgcagagc tggtcatccc agaactgcca ctggcacacc cacctaatga gcgaacacac    720

ctggtcatcc tgggagccat tctgctgtgc ctgggcgtcg ctctgacttt catttttcgg    780

ctgagaaagg ggcggatgat ggacgtgaaa aagtgtggca ttcaggatac taactcaaaa    840

aagcagtccg atacccatct ggaagaaacc                                     870


<210>  14
<211>  290
<212>  PRT
<213>  Artificial

<220>
<223>  PD-L1׵İ

<400>  14

Met Arg Ile Phe Ala Val Phe Ile Phe Met Thr Tyr Trp His Leu Leu 
1               5                   10                  15      


Asn Ala Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Val Val Glu Tyr 
            20                  25                  30          


Gly Ser Asn Met Thr Ile Glu Cys Lys Phe Pro Val Glu Lys Gln Leu 
        35                  40                  45              


Asp Leu Ala Ala Leu Ile Val Tyr Trp Glu Met Glu Asp Lys Asn Ile 
    50                  55                  60                  


Ile Gln Phe Val His Gly Glu Glu Asp Leu Lys Val Gln His Ser Ser 
65                  70                  75                  80  


Tyr Arg Gln Arg Ala Arg Leu Leu Lys Asp Gln Leu Ser Leu Gly Asn 
                85                  90                  95      


Ala Ala Leu Gln Ile Thr Asp Val Lys Leu Gln Asp Ala Gly Val Tyr 
            100                 105                 110         


Arg Cys Met Ile Ser Tyr Gly Gly Ala Asp Tyr Lys Arg Ile Thr Val 
        115                 120                 125             


Lys Val Asn Ala Pro Tyr Asn Lys Ile Asn Gln Arg Ile Leu Val Val 
    130                 135                 140                 


Asp Pro Val Thr Ser Glu His Glu Leu Thr Cys Gln Ala Glu Gly Tyr 
145                 150                 155                 160 


Pro Lys Ala Glu Val Ile Trp Thr Ser Ser Asp His Gln Val Leu Ser 
                165                 170                 175     


Gly Lys Thr Thr Thr Thr Asn Ser Lys Arg Glu Glu Lys Leu Phe Asn 
            180                 185                 190         


Val Thr Ser Thr Leu Arg Ile Asn Thr Thr Thr Asn Glu Ile Phe Tyr 
        195                 200                 205             


Cys Thr Phe Arg Arg Leu Asp Pro Glu Glu Asn His Thr Ala Glu Leu 
    210                 215                 220                 


Val Ile Pro Glu Leu Pro Leu Ala His Pro Pro Asn Glu Arg Thr His 
225                 230                 235                 240 


Leu Val Ile Leu Gly Ala Ile Leu Leu Cys Leu Gly Val Ala Leu Thr 
                245                 250                 255     


Phe Ile Phe Arg Leu Arg Lys Gly Arg Met Met Asp Val Lys Lys Cys 
            260                 265                 270         


Gly Ile Gln Asp Thr Asn Ser Lys Lys Gln Ser Asp Thr His Leu Glu 
        275                 280                 285             


Glu Thr 
    290 


<210>  15
<211>  8
<212>  PRT
<213>  Artificial

<220>
<223>  HCDR1

<400>  15

Gly Phe Ser Leu Ser Asn Tyr Asp 
1               5               


<210>  16
<211>  7
<212>  PRT
<213>  Artificial

<220>
<223>  HCDR2

<400>  16

Ile Trp Thr Gly Gly Ala Thr 
1               5           


<210>  17
<211>  14
<212>  PRT
<213>  Artificial

<220>
<223>  HCDR3

<400>  17

Val Arg Asp Ser Asn Tyr Arg Tyr Asp Glu Pro Phe Thr Tyr 
1               5                   10                  


<210>  18
<211>  6
<212>  PRT
<213>  Artificial

<220>
<223>  LCDR1

<400>  18

Gln Ser Ile Gly Thr Asn 
1               5       


<210>  19
<211>  3
<212>  PRT
<213>  Artificial

<220>
<223>  LCDR2

<400>  19

Tyr Ala Ser 
1           


<210>  20
<211>  9
<212>  PRT
<213>  Artificial

<220>
<223>  LCDR3

<400>  20

Gln Gln Ser Asn Ser Trp Pro Tyr Thr 
1               5                   

                                                                                                                                                                                                                                                                                                                                                                                                                                    