                         SEQUENCE LISTING

<110>  ImmPACT-Bio Ltd.
 
<120>  METHODS FOR IDENTIFYING ACTIVATING ANTIGEN RECEPTOR 
       (aCAR)/INHIBITORY CHIMERIC ANTIGEN RECEPTOR (iCAR) PAIRS FOR USE 
       IN CANCER THERA

<130>  120575-5004-WO

<140>  PCT/IB2019/001108
<141>  2019-09-27

<150>  US 62/847,830
<151>  2019-05-14

<150>  US 62/738,895
<151>  2018-09-28

<160>  49    

<170>  PatentIn version 3.5

<210>  1
<211>  3432
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CD19 aCAR_IRES_RFP_P2A_Puro

<400>  1
atggccttac cagtgaccgc cttgctcctg ccgctggcct tgctgctcca cgccgccagg       60

ccggacatcc agatgacaca gactacatcc tccctgtctg cctctctggg agacagagtc      120

accatcagtt gcagggcaag tcaggacatt agtaaatatt taaattggta tcagcagaaa      180

ccagatggaa ctgttaaact cctgatctac catacatcaa gattacactc aggagtccca      240

tcaaggttca gtggcagtgg gtctggaaca gattattctc tcaccattag caacctggag      300

caagaagata ttgccactta cttttgccaa cagggtaata cgcttccgta cacgttcgga      360

ggggggacca agctggagat cacaggtggc ggtggctcgg gcggtggtgg gtcgggtggc      420

ggcggatctg aggtgaaact gcaggagtca ggacctggcc tggtggcgcc ctcacagagc      480

ctgtccgtca catgcactgt ctcaggggtc tcattacccg actatggtgt aagctggatt      540

cgccagcctc cacgaaaggg tctggagtgg ctgggagtaa tatggggtag tgaaaccaca      600

tactataatt cagctctcaa atccagactg accatcatca aggacaactc caagagccaa      660

gttttcttaa aaatgaacag tctgcaaact gatgacacag ccatttacta ctgtgccaaa      720

cattattact acggtggtag ctatgctatg gactactggg gccaaggaac ctcagtcacc      780

gtctcctcaa ccactacccc agcaccgagg ccacccaccc cggctcctac catcgcctcc      840

cagcctctgt ccctgcgtcc ggaggcatgt agacccgcag ctggtggggc cgtgcatacc      900

cggggtcttg acttcgcctg cgatatctac atttgggccc ctctggctgg tacttgcggg      960

gtcctgctgc tttcactcgt gatcactctt tactgtaagc gcggtcggaa gaagctgctg     1020

tacatcttta agcaaccctt catgaggcct gtgcagacta ctcaagagga ggacggctgt     1080

tcatgccggt tcccagagga ggaggaaggc ggctgcgaac tgcgcgtgaa attcagccgc     1140

agcgcagatg ctccagccta caagcagggg cagaaccagc tctacaacga actcaatctt     1200

ggtcggagag aggagtacga cgtgctggac aagcggagag gacgggaccc agaaatgggc     1260

gggaagccgc gcagaaagaa tccccaagag ggcctgtaca acgagctcca aaaggataag     1320

atggcagaag cctatagcga gattggtatg aaaggggaac gcagaagagg caaaggccac     1380

gacggactgt accagggact cagcaccgcc accaaggaca cctatgacgc tcttcacatg     1440

caggccctgc cgcctcggtg agcggccgca aattccgccc ctctccctcc ccccccccta     1500

acgttactgg ccgaagccgc ttggaataag gccggtgtgc gtttgtctat atgttatttt     1560

ccaccatatt gccgtctttt ggcaatgtga gggcccggaa acctggccct gtcttcttga     1620

cgagcattcc taggggtctt tcccctctcg ccaaaggaat gcaaggtctg ttgaatgtcg     1680

tgaaggaagc agttcctctg gaagcttctt gaagacaaac aacgtctgta gcgacccttt     1740

gcaggcagcg gaacccccca cctggcgaca ggtgcctctg cggccaaaag ccacgtgtat     1800

aagatacacc tgcaaaggcg gcacaacccc agtgccacgt tgtgagttgg atagttgtgg     1860

aaagagtcaa atggctctcc tcaagcgtat tcaacaaggg gctgaaggat gcccagaagg     1920

taccccattg tatgggatct gatctggggc ctcggtgcac atgctttaca tgtgtttagt     1980

cgaggttaaa aaaacgtcta ggccccccga accacgggga cgtggttttc ctttgaaaaa     2040

cacgataata ccatggtgtc taagggcgaa gagctgatta aggagaacat gcacatgaag     2100

ctgtacatgg agggcaccgt gaacaaccac cacttcaagt gcacatccga gggcgaaggc     2160

aagccctacg agggcaccca gaccatgaga atcaaggtgg tcgagggcgg ccctctcccc     2220

ttcgccttcg acatcctggc taccagcttc atgtacggca gcagaacctt catcaaccac     2280

acccagggca tccccgactt ctttaagcag tccttccctg agggcttcac atgggagaga     2340

gtcaccacat acgaagacgg gggcgtgctg accgctaccc aggacaccag cctccaggac     2400

ggctgcctca tctacaacgt caagatcaga ggggtgaact tcccatccaa cggccctgtg     2460

atgcagaaga aaacactcgg ctgggaggcc aacaccgaga tgctgtaccc cgctgacggc     2520

ggcctggaag gcagaagcga catggccctg aagctcgtgg gcgggggcca cctgatctgc     2580

aacttcaaga ccacatacag atccaagaaa cccgctaaga acctcaagat gcccggcgtc     2640

tactatgtgg accacagact ggaaagaatc aaggaggccg acaaagagac ctacgtcgag     2700

cagcacgagg tggctgtggc cagatactgc gacctcccta gcaaactggg gcacaaactt     2760

aatggatccg gcgcgacaaa ctttagcttg ctgaagcaag ctggtgacgt ggaggagaat     2820

cccggcccta tggccaccga gtacaagccc acggtgcgcc tcgccacccg cgacgacgtc     2880

ccccgggccg tacgcaccct cgccgccgcg ttcgccgact accccgccac gcgccacacc     2940

gtcgatccgg accgccacat cgagcgggtc accgagctgc aagaactctt cctcacgcgc     3000

gtcgggctcg acatcggcaa ggtgtgggtc gcggacgacg gcgccgcggt ggcggtctgg     3060

accacgccgg agagcgtcga agcgggggcg gtgttcgccg agatcggccc gcgcatggcc     3120

gagttgagcg gttcccggct ggccgcgcag caacagatgg aaggcctcct ggcgccgcac     3180

cggcccaagg agcccgcgtg gttcctggcc accgtcggcg tctcgcccga ccaccagggc     3240

aagggtctgg gcagcgccgt cgtgctcccc ggagtggagg cggccgagcg cgccggggtg     3300

cccgccttcc tggagacctc cgcgccccgc aacctcccct tctacgagcg gctcggcttc     3360

accgtcaccg ccgacgtcga ggtgcccgaa ggaccgcgca cctggtgcat gacccgcaag     3420

cccggtgcct ga                                                         3432


<210>  2
<211>  486
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD19 aCAR

<400>  2

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Asp Ile Gln Met Thr Gln Thr Thr Ser Ser Leu 
            20                  25                  30          


Ser Ala Ser Leu Gly Asp Arg Val Thr Ile Ser Cys Arg Ala Ser Gln 
        35                  40                  45              


Asp Ile Ser Lys Tyr Leu Asn Trp Tyr Gln Gln Lys Pro Asp Gly Thr 
    50                  55                  60                  


Val Lys Leu Leu Ile Tyr His Thr Ser Arg Leu His Ser Gly Val Pro 
65                  70                  75                  80  


Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Tyr Ser Leu Thr Ile 
                85                  90                  95      


Ser Asn Leu Glu Gln Glu Asp Ile Ala Thr Tyr Phe Cys Gln Gln Gly 
            100                 105                 110         


Asn Thr Leu Pro Tyr Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Thr 
        115                 120                 125             


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu 
    130                 135                 140                 


Val Lys Leu Gln Glu Ser Gly Pro Gly Leu Val Ala Pro Ser Gln Ser 
145                 150                 155                 160 


Leu Ser Val Thr Cys Thr Val Ser Gly Val Ser Leu Pro Asp Tyr Gly 
                165                 170                 175     


Val Ser Trp Ile Arg Gln Pro Pro Arg Lys Gly Leu Glu Trp Leu Gly 
            180                 185                 190         


Val Ile Trp Gly Ser Glu Thr Thr Tyr Tyr Asn Ser Ala Leu Lys Ser 
        195                 200                 205             


Arg Leu Thr Ile Ile Lys Asp Asn Ser Lys Ser Gln Val Phe Leu Lys 
    210                 215                 220                 


Met Asn Ser Leu Gln Thr Asp Asp Thr Ala Ile Tyr Tyr Cys Ala Lys 
225                 230                 235                 240 


His Tyr Tyr Tyr Gly Gly Ser Tyr Ala Met Asp Tyr Trp Gly Gln Gly 
                245                 250                 255     


Thr Ser Val Thr Val Ser Ser Thr Thr Thr Pro Ala Pro Arg Pro Pro 
            260                 265                 270         


Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu 
        275                 280                 285             


Ala Cys Arg Pro Ala Ala Gly Gly Ala Val His Thr Arg Gly Leu Asp 
    290                 295                 300                 


Phe Ala Cys Asp Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr Cys Gly 
305                 310                 315                 320 


Val Leu Leu Leu Ser Leu Val Ile Thr Leu Tyr Cys Lys Arg Gly Arg 
                325                 330                 335     


Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met Arg Pro Val Gln 
            340                 345                 350         


Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe Pro Glu Glu Glu 
        355                 360                 365             


Glu Gly Gly Cys Glu Leu Arg Val Lys Phe Ser Arg Ser Ala Asp Ala 
    370                 375                 380                 


Pro Ala Tyr Lys Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu 
385                 390                 395                 400 


Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp 
                405                 410                 415     


Pro Glu Met Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu 
            420                 425                 430         


Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile 
        435                 440                 445             


Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr 
    450                 455                 460                 


Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met 
465                 470                 475                 480 


Gln Ala Leu Pro Pro Arg 
                485     


<210>  3
<211>  237
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  RFP

<400>  3

Met Val Ser Lys Gly Glu Glu Leu Ile Lys Glu Asn Met His Met Lys 
1               5                   10                  15      


Leu Tyr Met Glu Gly Thr Val Asn Asn His His Phe Lys Cys Thr Ser 
            20                  25                  30          


Glu Gly Glu Gly Lys Pro Tyr Glu Gly Thr Gln Thr Met Arg Ile Lys 
        35                  40                  45              


Val Val Glu Gly Gly Pro Leu Pro Phe Ala Phe Asp Ile Leu Ala Thr 
    50                  55                  60                  


Ser Phe Met Tyr Gly Ser Arg Thr Phe Ile Asn His Thr Gln Gly Ile 
65                  70                  75                  80  


Pro Asp Phe Phe Lys Gln Ser Phe Pro Glu Gly Phe Thr Trp Glu Arg 
                85                  90                  95      


Val Thr Thr Tyr Glu Asp Gly Gly Val Leu Thr Ala Thr Gln Asp Thr 
            100                 105                 110         


Ser Leu Gln Asp Gly Cys Leu Ile Tyr Asn Val Lys Ile Arg Gly Val 
        115                 120                 125             


Asn Phe Pro Ser Asn Gly Pro Val Met Gln Lys Lys Thr Leu Gly Trp 
    130                 135                 140                 


Glu Ala Asn Thr Glu Met Leu Tyr Pro Ala Asp Gly Gly Leu Glu Gly 
145                 150                 155                 160 


Arg Ser Asp Met Ala Leu Lys Leu Val Gly Gly Gly His Leu Ile Cys 
                165                 170                 175     


Asn Phe Lys Thr Thr Tyr Arg Ser Lys Lys Pro Ala Lys Asn Leu Lys 
            180                 185                 190         


Met Pro Gly Val Tyr Tyr Val Asp His Arg Leu Glu Arg Ile Lys Glu 
        195                 200                 205             


Ala Asp Lys Glu Thr Tyr Val Glu Gln His Glu Val Ala Val Ala Arg 
    210                 215                 220                 


Tyr Cys Asp Leu Pro Ser Lys Leu Gly His Lys Leu Asn 
225                 230                 235         


<210>  4
<211>  200
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Puromycin resistance

<400>  4

Met Ala Thr Glu Tyr Lys Pro Thr Val Arg Leu Ala Thr Arg Asp Asp 
1               5                   10                  15      


Val Pro Arg Ala Val Arg Thr Leu Ala Ala Ala Phe Ala Asp Tyr Pro 
            20                  25                  30          


Ala Thr Arg His Thr Val Asp Pro Asp Arg His Ile Glu Arg Val Thr 
        35                  40                  45              


Glu Leu Gln Glu Leu Phe Leu Thr Arg Val Gly Leu Asp Ile Gly Lys 
    50                  55                  60                  


Val Trp Val Ala Asp Asp Gly Ala Ala Val Ala Val Trp Thr Thr Pro 
65                  70                  75                  80  


Glu Ser Val Glu Ala Gly Ala Val Phe Ala Glu Ile Gly Pro Arg Met 
                85                  90                  95      


Ala Glu Leu Ser Gly Ser Arg Leu Ala Ala Gln Gln Gln Met Glu Gly 
            100                 105                 110         


Leu Leu Ala Pro His Arg Pro Lys Glu Pro Ala Trp Phe Leu Ala Thr 
        115                 120                 125             


Val Gly Val Ser Pro Asp His Gln Gly Lys Gly Leu Gly Ser Ala Val 
    130                 135                 140                 


Val Leu Pro Gly Val Glu Ala Ala Glu Arg Ala Gly Val Pro Ala Phe 
145                 150                 155                 160 


Leu Glu Thr Ser Ala Pro Arg Asn Leu Pro Phe Tyr Glu Arg Leu Gly 
                165                 170                 175     


Phe Thr Val Thr Ala Asp Val Glu Val Pro Glu Gly Pro Arg Thr Trp 
            180                 185                 190         


Cys Met Thr Arg Lys Pro Gly Ala 
        195                 200 


<210>  5
<211>  3669
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CD20 iCAR_IRES_GFP_P2A_Hygro

<400>  5
atggcactgc ctgtgaccgc cctgctgctg ccactggccc tgctgctgca cgcagccagg       60

cccgacatcg tgctgacaca gagcccagca atcctgtccg cctctcctgg agagaaggtg      120

accatgacat gccgcgccag ctcctctgtg aactacatgg attggtatca gaagaagcct      180

ggcagctccc caaagccctg gatctacgcc accagcaatc tggcctccgg cgtgccagca      240

cggttcagcg gctccggctc tggcaccagc tattccctga caatctccag agtggaggca      300

gaggacgcag caacctacta ttgccagcag tggtctttca acccccctac ctttggcggc      360

ggcacaaagc tggagatcaa gggctctaca agcggaggag gctctggagg aggcagcgga      420

ggcggcggct ctagcgaggt gcagctgcag cagagcggag cagagctggt gaagcctgga      480

gcctccgtga agatgtcttg taaggccagc ggctacacct tcacatccta taatatgcac      540

tgggtgaagc agaccccagg acagggcctg gagtggatcg gagcaatcta cccaggaaac      600

ggcgacacaa gctataatca gaagtttaag ggcaaggcca ccctgacagc cgataagtcc      660

tctagcaccg cctacatgca gctgtcctct ctgacatccg aggactctgc cgattactat      720

tgtgcccggt ccaactacta tggcagctcc tactggttct ttgacgtgtg gggagcaggc      780

accacagtga ccgtgtctag caccgagagg agagcagagg tgcccacagc acacccatct      840

ccaagcccta ggccagcagg acagttccag accctggtgg tgggagtggt gggaggcctg      900

ctgggctctc tggtgctgct ggtgtgggtg ctggccgtga tctgcagcag ggccgcccgc      960

ggcaccatcg gcgccaggcg cacaggccag cctctgaagg aggacccttc cgccgtgcca     1020

gtgttctctg tggactacgg cgagctggat tttcagtggc gggagaaaac cccagagcca     1080

cctgtgccct gcgtgcctga gcagaccgag tatgccacaa tcgtgtttcc atccggaatg     1140

ggcacaagct cccctgcaag gagaggcagc gccgacggac cacggtccgc ccagccactg     1200

cggcccgagg atggccactg ttcttggccc ctgtgacgcc cctctccccc ccccccctct     1260

ccctcccccc cccctaacgt tactggccga agccgcttgg aataaggccg gtgtgcgttt     1320

gtctatatgt tattttccac catattgccg tcttttggca atgtgagggc ccggaaacct     1380

ggccctgtct tcttgacgag cattcctagg ggtctttccc ctctcgccaa aggaatgcaa     1440

ggtctgttga atgtcgtgaa ggaagcagtt cctctggaag cttcttgaag acaaacaacg     1500

tctgtagcga ccctttgcag gcagcggaac cccccacctg gcgacaggtg cctctgcggc     1560

caaaagccac gtgtataaga tacacctgca aaggcggcac aaccccagtg ccacgttgtg     1620

agttggatag ttgtggaaag agtcaaatgg ctctcctcaa gcgtattcaa caaggggctg     1680

aaggatgccc agaaggtacc ccattgtatg ggatctgatc tggggcctcg gtgcacatgc     1740

tttacatgtg tttagtcgag gttaaaaaaa cgtctaggcc ccccgaacca cggggacgtg     1800

gttttccttt gaaaaacacg atgataaggc ttgccacaac ccgtaccaaa gatggtgtcc     1860

aagggagagg agctgttcac cggagtggtg cccatcctgg tggagctgga cggcgatgtg     1920

aatggccaca agtttagcgt gtccggagag ggagagggcg acgcaaccta cggcaagctg     1980

acactgaagt tcatctgcac cacaggcaag ctgcccgtgc cttggccaac cctggtgacc     2040

acactgacat acggcgtgca gtgtttttct cgctatcccg accacatgaa gcagcacgat     2100

ttctttaaga gcgccatgcc tgagggctac gtgcaggagc ggaccatctt ctttaaggac     2160

gatggcaact ataagaccag agccgaggtg aagttcgagg gcgacacact ggtgaacagg     2220

atcgagctga agggcatcga ctttaaggag gatggcaata tcctgggcca caagctggag     2280

tacaactata attcccacaa cgtgtacatc atggccgata agcagaagaa cggcatcaag     2340

gtcaatttca agatcagaca caatatcgag gacggctctg tgcagctggc cgatcactac     2400

cagcagaaca ccccaatcgg cgacggaccc gtgctgctgc ctgataatca ctatctgtct     2460

acacagagcg ccctgtccaa ggaccccaac gagaagaggg atcacatggt gctgctggag     2520

tttgtgaccg cagcaggaat cacactggga atggacgagc tgtataaggg cagcggcgcc     2580

accaacttct ccctgctgaa gcaggcaggc gacgtggagg agaatccagg acctatggat     2640

agaagcggca agccagagct gaccgccaca tccgtggaga agttcctgat cgagaagttt     2700

gactctgtga gcgatctgat gcagctgtcc gagggagagg agtccagggc cttctctttt     2760

gatgtgggcg gcaggggata cgtgctgagg gtgaatagct gcgccgacgg cttctataag     2820

gatagatacg tgtatagaca ctttgcctcc gccgccctgc caatcccaga ggtgctggac     2880

atcggcgagt tttccgagtc tctgacctac tgtatcagcc ggagagccca gggagtgacc     2940

ctgcaggatc tgcctgagac agagctgcca gccgtgctgc agccagtggc agaggctatg     3000

gacgcaatcg ccgccgccga cctgtctcag acaagcggct tcggcccttt tggcccacag     3060

ggcatcggcc agtacaccac atggagggac ttcatctgcg ccatcgccga tcctcacgtg     3120

tatcactggc agaccgtgat ggacgataca gtgagcgcct ccgtggcaca ggccctggac     3180

gagctgatgc tgtgggccga ggattgtcca gaggtgcgcc acctggtgca cgcagacttt     3240

ggcagcaaca atgtgctgac cgataatggc cggatcacag ccgtgatcga ctggtccgag     3300

gccatgttcg gcgattctca gtacgaggtg gccaacatct tcttttggag gccttggctg     3360

gcctgcatgg agcagcagac ccgctatttt gagaggcgcc accctgagct ggccggctct     3420

ccacggctga gagcatacat gctgcgcatc ggcctggacc agctgtatca gagcctggtg     3480

gatggcaatt tcgacgatgc agcatgggca cagggccggt gcgacgcaat cgtgagatcc     3540

ggcgccggca ccgtgggccg gacacagatc gcacggcgga gcgccgccgt gtggaccgac     3600

ggatgcgtgg aggtgctggc cgattctggc aacaggcgcc caagcacaag gccccgcgcc     3660

aaggagtga                                                             3669


<210>  6
<211>  411
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD20 iCAR

<400>  6

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Asp Ile Val Leu Thr Gln Ser Pro Ala Ile Leu 
            20                  25                  30          


Ser Ala Ser Pro Gly Glu Lys Val Thr Met Thr Cys Arg Ala Ser Ser 
        35                  40                  45              


Ser Val Asn Tyr Met Asp Trp Tyr Gln Lys Lys Pro Gly Ser Ser Pro 
    50                  55                  60                  


Lys Pro Trp Ile Tyr Ala Thr Ser Asn Leu Ala Ser Gly Val Pro Ala 
65                  70                  75                  80  


Arg Phe Ser Gly Ser Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile Ser 
                85                  90                  95      


Arg Val Glu Ala Glu Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Trp Ser 
            100                 105                 110         


Phe Asn Pro Pro Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Gly 
        115                 120                 125             


Ser Thr Ser Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Gly Ser 
    130                 135                 140                 


Ser Glu Val Gln Leu Gln Gln Ser Gly Ala Glu Leu Val Lys Pro Gly 
145                 150                 155                 160 


Ala Ser Val Lys Met Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser 
                165                 170                 175     


Tyr Asn Met His Trp Val Lys Gln Thr Pro Gly Gln Gly Leu Glu Trp 
            180                 185                 190         


Ile Gly Ala Ile Tyr Pro Gly Asn Gly Asp Thr Ser Tyr Asn Gln Lys 
        195                 200                 205             


Phe Lys Gly Lys Ala Thr Leu Thr Ala Asp Lys Ser Ser Ser Thr Ala 
    210                 215                 220                 


Tyr Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Asp Tyr Tyr 
225                 230                 235                 240 


Cys Ala Arg Ser Asn Tyr Tyr Gly Ser Ser Tyr Trp Phe Phe Asp Val 
                245                 250                 255     


Trp Gly Ala Gly Thr Thr Val Thr Val Ser Ser Thr Glu Arg Arg Ala 
            260                 265                 270         


Glu Val Pro Thr Ala His Pro Ser Pro Ser Pro Arg Pro Ala Gly Gln 
        275                 280                 285             


Phe Gln Thr Leu Val Val Gly Val Val Gly Gly Leu Leu Gly Ser Leu 
    290                 295                 300                 


Val Leu Leu Val Trp Val Leu Ala Val Ile Cys Ser Arg Ala Ala Arg 
305                 310                 315                 320 


Gly Thr Ile Gly Ala Arg Arg Thr Gly Gln Pro Leu Lys Glu Asp Pro 
                325                 330                 335     


Ser Ala Val Pro Val Phe Ser Val Asp Tyr Gly Glu Leu Asp Phe Gln 
            340                 345                 350         


Trp Arg Glu Lys Thr Pro Glu Pro Pro Val Pro Cys Val Pro Glu Gln 
        355                 360                 365             


Thr Glu Tyr Ala Thr Ile Val Phe Pro Ser Gly Met Gly Thr Ser Ser 
    370                 375                 380                 


Pro Ala Arg Arg Gly Ser Ala Asp Gly Pro Arg Ser Ala Gln Pro Leu 
385                 390                 395                 400 


Arg Pro Glu Asp Gly His Cys Ser Trp Pro Leu 
                405                 410     


<210>  7
<211>  239
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GFP

<400>  7

Met Val Ser Lys Gly Glu Glu Leu Phe Thr Gly Val Val Pro Ile Leu 
1               5                   10                  15      


Val Glu Leu Asp Gly Asp Val Asn Gly His Lys Phe Ser Val Ser Gly 
            20                  25                  30          


Glu Gly Glu Gly Asp Ala Thr Tyr Gly Lys Leu Thr Leu Lys Phe Ile 
        35                  40                  45              


Cys Thr Thr Gly Lys Leu Pro Val Pro Trp Pro Thr Leu Val Thr Thr 
    50                  55                  60                  


Leu Thr Tyr Gly Val Gln Cys Phe Ser Arg Tyr Pro Asp His Met Lys 
65                  70                  75                  80  


Gln His Asp Phe Phe Lys Ser Ala Met Pro Glu Gly Tyr Val Gln Glu 
                85                  90                  95      


Arg Thr Ile Phe Phe Lys Asp Asp Gly Asn Tyr Lys Thr Arg Ala Glu 
            100                 105                 110         


Val Lys Phe Glu Gly Asp Thr Leu Val Asn Arg Ile Glu Leu Lys Gly 
        115                 120                 125             


Ile Asp Phe Lys Glu Asp Gly Asn Ile Leu Gly His Lys Leu Glu Tyr 
    130                 135                 140                 


Asn Tyr Asn Ser His Asn Val Tyr Ile Met Ala Asp Lys Gln Lys Asn 
145                 150                 155                 160 


Gly Ile Lys Val Asn Phe Lys Ile Arg His Asn Ile Glu Asp Gly Ser 
                165                 170                 175     


Val Gln Leu Ala Asp His Tyr Gln Gln Asn Thr Pro Ile Gly Asp Gly 
            180                 185                 190         


Pro Val Leu Leu Pro Asp Asn His Tyr Leu Ser Thr Gln Ser Ala Leu 
        195                 200                 205             


Ser Lys Asp Pro Asn Glu Lys Arg Asp His Met Val Leu Leu Glu Phe 
    210                 215                 220                 


Val Thr Ala Ala Gly Ile Thr Leu Gly Met Asp Glu Leu Tyr Lys 
225                 230                 235                 


<210>  8
<211>  344
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Hygromycin resistance

<400>  8

Met Asp Arg Ser Gly Lys Pro Glu Leu Thr Ala Thr Ser Val Glu Lys 
1               5                   10                  15      


Phe Leu Ile Glu Lys Phe Asp Ser Val Ser Asp Leu Met Gln Leu Ser 
            20                  25                  30          


Glu Gly Glu Glu Ser Arg Ala Phe Ser Phe Asp Val Gly Gly Arg Gly 
        35                  40                  45              


Tyr Val Leu Arg Val Asn Ser Cys Ala Asp Gly Phe Tyr Lys Asp Arg 
    50                  55                  60                  


Tyr Val Tyr Arg His Phe Ala Ser Ala Ala Leu Pro Ile Pro Glu Val 
65                  70                  75                  80  


Leu Asp Ile Gly Glu Phe Ser Glu Ser Leu Thr Tyr Cys Ile Ser Arg 
                85                  90                  95      


Arg Ala Gln Gly Val Thr Leu Gln Asp Leu Pro Glu Thr Glu Leu Pro 
            100                 105                 110         


Ala Val Leu Gln Pro Val Ala Glu Ala Met Asp Ala Ile Ala Ala Ala 
        115                 120                 125             


Asp Leu Ser Gln Thr Ser Gly Phe Gly Pro Phe Gly Pro Gln Gly Ile 
    130                 135                 140                 


Gly Gln Tyr Thr Thr Trp Arg Asp Phe Ile Cys Ala Ile Ala Asp Pro 
145                 150                 155                 160 


His Val Tyr His Trp Gln Thr Val Met Asp Asp Thr Val Ser Ala Ser 
                165                 170                 175     


Val Ala Gln Ala Leu Asp Glu Leu Met Leu Trp Ala Glu Asp Cys Pro 
            180                 185                 190         


Glu Val Arg His Leu Val His Ala Asp Phe Gly Ser Asn Asn Val Leu 
        195                 200                 205             


Thr Asp Asn Gly Arg Ile Thr Ala Val Ile Asp Trp Ser Glu Ala Met 
    210                 215                 220                 


Phe Gly Asp Ser Gln Tyr Glu Val Ala Asn Ile Phe Phe Trp Arg Pro 
225                 230                 235                 240 


Trp Leu Ala Cys Met Glu Gln Gln Thr Arg Tyr Phe Glu Arg Arg His 
                245                 250                 255     


Pro Glu Leu Ala Gly Ser Pro Arg Leu Arg Ala Tyr Met Leu Arg Ile 
            260                 265                 270         


Gly Leu Asp Gln Leu Tyr Gln Ser Leu Val Asp Gly Asn Phe Asp Asp 
        275                 280                 285             


Ala Ala Trp Ala Gln Gly Arg Cys Asp Ala Ile Val Arg Ser Gly Ala 
    290                 295                 300                 


Gly Thr Val Gly Arg Thr Gln Ile Ala Arg Arg Ser Ala Ala Val Trp 
305                 310                 315                 320 


Thr Asp Gly Cys Val Glu Val Leu Ala Asp Ser Gly Asn Arg Arg Pro 
                325                 330                 335     


Ser Thr Arg Pro Arg Ala Lys Glu 
            340                 


<210>  9
<211>  3696
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HLA-A2 iCAR_IRES_ GFP_P2A_Hygro

<400>  9
atggcactgc cagtgaccgc cctgctgctg cctctggccc tgctgctgca cgcagccaga       60

cccgagcaga agctgatctc cgaggaggac ctgcaggtgc agctgcagca gtctggacct      120

gagctggtga agccaggagc ctccgtgaag atgtcttgca aggccagcgg ctacaccttc      180

acatcttatc acatccagtg ggtgaagcag cggcccggac agggcctgga gtggatcgga      240

tggatctacc caggcgacgg ctccacacag tataacgaga agttcaaggg caagaccaca      300

ctgaccgccg ataagagcag cagcaccgcc tacatgctgc tgagcagcct gaccagcgag      360

gacagcgcca tctacttttg cgccagggag ggcacatact atgctatgga ctattggggc      420

cagggcacca gcgtgacagt gtctagcgga ggaggaggct ccggaggagg aggctctggc      480

ggcggcggca gcgacgtgct gatgacccag acaccactga gcctgcccgt gagcctgggc      540

gatcaggtga gcatctcctg tagatcctct cagagcatcg tgcactccaa cggcaatacc      600

tacctggagt ggtatctgca gaagccaggc cagtccccca agctgctgat ctataaggtg      660

tctaatcggt tcagcggcgt gcctgacaga ttttctggca gcggctccgg caccgacttc      720

accctgaaga tcagccgggt ggaggcagag gatctgggcg tgtactattg tttccagggc      780

tcccacgtgc cacgcacctt tggcggcggc acaaagctgg agatcaagac cgagaggaga      840

gcagaggtgc ccacagcaca cccatctcca agccctaggc cagcaggaca gttccagacc      900

ctggtggtgg gagtggtggg aggcctgctg ggctctctgg tgctgctggt gtgggtgctg      960

gccgtgatct gcagcagggc cgcccgcggc accatcggcg ccaggcgcac aggccagcct     1020

ctgaaggagg acccttccgc cgtgccagtg ttctctgtgg actacggcga gctggatttt     1080

cagtggcggg agaaaacccc agagccacct gtgccctgcg tgcctgagca gaccgagtat     1140

gccacaatcg tgtttccatc cggaatgggc acaagctccc ctgcaaggag aggcagcgcc     1200

gacggaccac ggtccgccca gccactgcgg cccgaggatg gccactgttc ttggcccctg     1260

tgacgcccct ctcccccccc cccctctccc tccccccccc ctaacgttac tggccgaagc     1320

cgcttggaat aaggccggtg tgcgtttgtc tatatgttat tttccaccat attgccgtct     1380

tttggcaatg tgagggcccg gaaacctggc cctgtcttct tgacgagcat tcctaggggt     1440

ctttcccctc tcgccaaagg aatgcaaggt ctgttgaatg tcgtgaagga agcagttcct     1500

ctggaagctt cttgaagaca aacaacgtct gtagcgaccc tttgcaggca gcggaacccc     1560

ccacctggcg acaggtgcct ctgcggccaa aagccacgtg tataagatac acctgcaaag     1620

gcggcacaac cccagtgcca cgttgtgagt tggatagttg tggaaagagt caaatggctc     1680

tcctcaagcg tattcaacaa ggggctgaag gatgcccaga aggtacccca ttgtatggga     1740

tctgatctgg ggcctcggtg cacatgcttt acatgtgttt agtcgaggtt aaaaaaacgt     1800

ctaggccccc cgaaccacgg ggacgtggtt ttcctttgaa aaacacgatg ataaggcttg     1860

ccacaacccg taccaaagat ggtgtccaag ggagaggagc tgttcaccgg agtggtgccc     1920

atcctggtgg agctggacgg cgatgtgaat ggccacaagt ttagcgtgtc cggagaggga     1980

gagggcgacg caacctacgg caagctgaca ctgaagttca tctgcaccac aggcaagctg     2040

cccgtgcctt ggccaaccct ggtgaccaca ctgacatacg gcgtgcagtg tttttctcgc     2100

tatcccgacc acatgaagca gcacgatttc tttaagagcg ccatgcctga gggctacgtg     2160

caggagcgga ccatcttctt taaggacgat ggcaactata agaccagagc cgaggtgaag     2220

ttcgagggcg acacactggt gaacaggatc gagctgaagg gcatcgactt taaggaggat     2280

ggcaatatcc tgggccacaa gctggagtac aactataatt cccacaacgt gtacatcatg     2340

gccgataagc agaagaacgg catcaaggtc aatttcaaga tcagacacaa tatcgaggac     2400

ggctctgtgc agctggccga tcactaccag cagaacaccc caatcggcga cggacccgtg     2460

ctgctgcctg ataatcacta tctgtctaca cagagcgccc tgtccaagga ccccaacgag     2520

aagagggatc acatggtgct gctggagttt gtgaccgcag caggaatcac actgggaatg     2580

gacgagctgt ataagggcag cggcgccacc aacttctccc tgctgaagca ggcaggcgac     2640

gtggaggaga atccaggacc tatggataga agcggcaagc cagagctgac cgccacatcc     2700

gtggagaagt tcctgatcga gaagtttgac tctgtgagcg atctgatgca gctgtccgag     2760

ggagaggagt ccagggcctt ctcttttgat gtgggcggca ggggatacgt gctgagggtg     2820

aatagctgcg ccgacggctt ctataaggat agatacgtgt atagacactt tgcctccgcc     2880

gccctgccaa tcccagaggt gctggacatc ggcgagtttt ccgagtctct gacctactgt     2940

atcagccgga gagcccaggg agtgaccctg caggatctgc ctgagacaga gctgccagcc     3000

gtgctgcagc cagtggcaga ggctatggac gcaatcgccg ccgccgacct gtctcagaca     3060

agcggcttcg gcccttttgg cccacagggc atcggccagt acaccacatg gagggacttc     3120

atctgcgcca tcgccgatcc tcacgtgtat cactggcaga ccgtgatgga cgatacagtg     3180

agcgcctccg tggcacaggc cctggacgag ctgatgctgt gggccgagga ttgtccagag     3240

gtgcgccacc tggtgcacgc agactttggc agcaacaatg tgctgaccga taatggccgg     3300

atcacagccg tgatcgactg gtccgaggcc atgttcggcg attctcagta cgaggtggcc     3360

aacatcttct tttggaggcc ttggctggcc tgcatggagc agcagacccg ctattttgag     3420

aggcgccacc ctgagctggc cggctctcca cggctgagag catacatgct gcgcatcggc     3480

ctggaccagc tgtatcagag cctggtggat ggcaatttcg acgatgcagc atgggcacag     3540

ggccggtgcg acgcaatcgt gagatccggc gccggcaccg tgggccggac acagatcgca     3600

cggcggagcg ccgccgtgtg gaccgacgga tgcgtggagg tgctggccga ttctggcaac     3660

aggcgcccaa gcacaaggcc ccgcgccaag gagtga                               3696


<210>  10
<211>  420
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HLA-A2 iCAR

<400>  10

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Glu Gln Lys Leu Ile Ser Glu Glu Asp Leu Gln 
            20                  25                  30          


Val Gln Leu Gln Gln Ser Gly Pro Glu Leu Val Lys Pro Gly Ala Ser 
        35                  40                  45              


Val Lys Met Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr His 
    50                  55                  60                  


Ile Gln Trp Val Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile Gly 
65                  70                  75                  80  


Trp Ile Tyr Pro Gly Asp Gly Ser Thr Gln Tyr Asn Glu Lys Phe Lys 
                85                  90                  95      


Gly Lys Thr Thr Leu Thr Ala Asp Lys Ser Ser Ser Thr Ala Tyr Met 
            100                 105                 110         


Leu Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Ile Tyr Phe Cys Ala 
        115                 120                 125             


Arg Glu Gly Thr Tyr Tyr Ala Met Asp Tyr Trp Gly Gln Gly Thr Ser 
    130                 135                 140                 


Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
145                 150                 155                 160 


Gly Gly Gly Ser Asp Val Leu Met Thr Gln Thr Pro Leu Ser Leu Pro 
                165                 170                 175     


Val Ser Leu Gly Asp Gln Val Ser Ile Ser Cys Arg Ser Ser Gln Ser 
            180                 185                 190         


Ile Val His Ser Asn Gly Asn Thr Tyr Leu Glu Trp Tyr Leu Gln Lys 
        195                 200                 205             


Pro Gly Gln Ser Pro Lys Leu Leu Ile Tyr Lys Val Ser Asn Arg Phe 
    210                 215                 220                 


Ser Gly Val Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe 
225                 230                 235                 240 


Thr Leu Lys Ile Ser Arg Val Glu Ala Glu Asp Leu Gly Val Tyr Tyr 
                245                 250                 255     


Cys Phe Gln Gly Ser His Val Pro Arg Thr Phe Gly Gly Gly Thr Lys 
            260                 265                 270         


Leu Glu Ile Lys Thr Glu Arg Arg Ala Glu Val Pro Thr Ala His Pro 
        275                 280                 285             


Ser Pro Ser Pro Arg Pro Ala Gly Gln Phe Gln Thr Leu Val Val Gly 
    290                 295                 300                 


Val Val Gly Gly Leu Leu Gly Ser Leu Val Leu Leu Val Trp Val Leu 
305                 310                 315                 320 


Ala Val Ile Cys Ser Arg Ala Ala Arg Gly Thr Ile Gly Ala Arg Arg 
                325                 330                 335     


Thr Gly Gln Pro Leu Lys Glu Asp Pro Ser Ala Val Pro Val Phe Ser 
            340                 345                 350         


Val Asp Tyr Gly Glu Leu Asp Phe Gln Trp Arg Glu Lys Thr Pro Glu 
        355                 360                 365             


Pro Pro Val Pro Cys Val Pro Glu Gln Thr Glu Tyr Ala Thr Ile Val 
    370                 375                 380                 


Phe Pro Ser Gly Met Gly Thr Ser Ser Pro Ala Arg Arg Gly Ser Ala 
385                 390                 395                 400 


Asp Gly Pro Arg Ser Ala Gln Pro Leu Arg Pro Glu Asp Gly His Cys 
                405                 410                 415     


Ser Trp Pro Leu 
            420 


<210>  11
<211>  1077
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  artificial construct

<400>  11
atggcactgc cagtgaccgc cctgctgctg cctctggccc tgctgctgca cgcagccaga       60

cccgagcaga agctgatctc cgaggaggac ctgcaggtgc agctgcagca gtctggacct      120

gagctggtga agccaggagc ctccgtgaag atgtcttgca aggccagcgg ctacaccttc      180

acatcttatc acatccagtg ggtgaagcag cggcccggac agggcctgga gtggatcgga      240

tggatctacc caggcgacgg ctccacacag tataacgaga agttcaaggg caagaccaca      300

ctgaccgccg ataagagcag cagcaccgcc tacatgctgc tgagcagcct gaccagcgag      360

gacagcgcca tctacttttg cgccagggag ggcacatact atgctatgga ctattggggc      420

cagggcacca gcgtgacagt gtctagcgga ggaggaggct ccggaggagg aggctctggc      480

ggcggcggca gcgacgtgct gatgacccag acaccactga gcctgcccgt gagcctgggc      540

gatcaggtga gcatctcctg tagatcctct cagagcatcg tgcactccaa cggcaatacc      600

tacctggagt ggtatctgca gaagccaggc cagtccccca agctgctgat ctataaggtg      660

tctaatcggt tcagcggcgt gcctgacaga ttttctggca gcggctccgg caccgacttc      720

accctgaaga tcagccgggt ggaggcagag gatctgggcg tgtactattg tttccagggc      780

tcccacgtgc cacgcacctt tggcggcggc acaaagctgg agatcaaggg catcggcaac      840

ggcacccaaa tctacgtgat cgacccagag ccctgccctg acagcgattt cctgctgtgg      900

attctggccg ccgtgagcag cggcctgttc ttttattcct ttctgctgac cgccgtgtct      960

ctgagcaaga tgctgaagaa gcggtctcct ctgaccacag gcgtgggcgt gaagatgccc     1020

cctacagagc ccgagtgtga gaagcagttc cagccatact ttatccccat caattga        1077


<210>  12
<211>  1146
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  artificial construct

<400>  12
atggcactgc cagtgaccgc cctgctgctg cctctggccc tgctgctgca cgcagccaga       60

cccgagcaga agctgatctc cgaggaggac ctgcaggtgc agctgcagca gtctggacct      120

gagctggtga agccaggagc ctccgtgaag atgtcttgca aggccagcgg ctacaccttc      180

acatcttatc acatccagtg ggtgaagcag cggcccggac agggcctgga gtggatcgga      240

tggatctacc caggcgacgg ctccacacag tataacgaga agttcaaggg caagaccaca      300

ctgaccgccg ataagagcag cagcaccgcc tacatgctgc tgagcagcct gaccagcgag      360

gacagcgcca tctacttttg cgccagggag ggcacatact atgctatgga ctattggggc      420

cagggcacca gcgtgacagt gtctagcgga ggaggaggct ccggaggagg aggctctggc      480

ggcggcggca gcgacgtgct gatgacccag acaccactga gcctgcccgt gagcctgggc      540

gatcaggtga gcatctcctg tagatcctct cagagcatcg tgcactccaa cggcaatacc      600

tacctggagt ggtatctgca gaagccaggc cagtccccca agctgctgat ctataaggtg      660

tctaatcggt tcagcggcgt gcctgacaga ttttctggca gcggctccgg caccgacttc      720

accctgaaga tcagccgggt ggaggcagag gatctgggcg tgtactattg tttccagggc      780

tcccacgtgc cacgcacctt tggcggcggc acaaagctgg agatcaagct gggcgccgcc      840

gtgtacttca ccgagctgag cagccctggc gcccagcggt ccggcagggc cccaggcgcc      900

ctgcctgccg gccacctgct gctgtttctg atcctgggcg tgctgtctct gctgctgctg      960

gtgacaggcg ccttcggctt tcacctgtgg cggagacagt ggcggcccag gcgcttctct     1020

gccctggagc agggcatcca cccacctcag gcacagagca agatcgagga gctggagcag     1080

gagccagagc cagagcctga acctgagcca gagcctgaac ccgagccaga gcctgagcag     1140

ctgtga                                                                1146


<210>  13
<211>  1272
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  artificial construct

<400>  13
atggcactgc cagtgaccgc cctgctgctg cctctggccc tgctgctgca cgcagccaga       60

cccgagcaga agctgatctc cgaggaggac ctgcaggtgc agctgcagca gtctggacct      120

gagctggtga agccaggagc ctccgtgaag atgtcttgca aggccagcgg ctacaccttc      180

acatcttatc acatccagtg ggtgaagcag cggcccggac agggcctgga gtggatcgga      240

tggatctacc caggcgacgg ctccacacag tataacgaga agttcaaggg caagaccaca      300

ctgaccgccg ataagagcag cagcaccgcc tacatgctgc tgagcagcct gaccagcgag      360

gacagcgcca tctacttttg cgccagggag ggcacatact atgctatgga ctattggggc      420

cagggcacca gcgtgacagt gtctagcgga ggaggaggct ccggaggagg aggctctggc      480

ggcggcggca gcgacgtgct gatgacccag acaccactga gcctgcccgt gagcctgggc      540

gatcaggtga gcatctcctg tagatcctct cagagcatcg tgcactccaa cggcaatacc      600

tacctggagt ggtatctgca gaagccaggc cagtccccca agctgctgat ctataaggtg      660

tctaatcggt tcagcggcgt gcctgacaga ttttctggca gcggctccgg caccgacttc      720

accctgaaga tcagccgggt ggaggcagag gatctgggcg tgtactattg tttccagggc      780

tcccacgtgc cacgcacctt tggcggcggc acaaagctgg agatcaagga gttccggttt      840

tggcccttcc tggtcatcat cgtgatcctg tctgccctgt tcctgggcac cctggcctgc      900

ttttgcgtgt ggcggagaaa gcggaaggag aagcagagcg agacctcccc caaggagttc      960

ctgacaatct acgaggacgt gaaggatctg aagacaaggc gcaaccacga gcaggagcag     1020

acctttcctg gcggcggctc tacaatctat agcatgatcc agtcccagag cagcgccccc     1080

accagccagg agcctgccta cacactgtat tctctgatcc agcctagcag aaagtctggc     1140

agccggaaga gaaaccactc cccatctttc aattccacca tctacgaagt gatcggcaag     1200

tctcagccaa aggcacagaa cccagcaagg ctgagccgca aggagctgga gaattttgac     1260

gtgtattcct ga                                                         1272


<210>  14
<211>  1296
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  artificial construct

<400>  14
atggcactgc cagtgaccgc cctgctgctg cctctggccc tgctgctgca cgcagccaga       60

cccgagcaga agctgatctc cgaggaggac ctgcaggtgc agctgcagca gtctggacct      120

gagctggtga agccaggagc ctccgtgaag atgtcttgca aggccagcgg ctacaccttc      180

acatcttatc acatccagtg ggtgaagcag cggcccggac agggcctgga gtggatcgga      240

tggatctacc caggcgacgg ctccacacag tataacgaga agttcaaggg caagaccaca      300

ctgaccgccg ataagagcag cagcaccgcc tacatgctgc tgagcagcct gaccagcgag      360

gacagcgcca tctacttttg cgccagggag ggcacatact atgctatgga ctattggggc      420

cagggcacca gcgtgacagt gtctagcgga ggaggaggct ccggaggagg aggctctggc      480

ggcggcggca gcgacgtgct gatgacccag acaccactga gcctgcccgt gagcctgggc      540

gatcaggtga gcatctcctg tagatcctct cagagcatcg tgcactccaa cggcaatacc      600

tacctggagt ggtatctgca gaagccaggc cagtccccca agctgctgat ctataaggtg      660

tctaatcggt tcagcggcgt gcctgacaga ttttctggca gcggctccgg caccgacttc      720

accctgaaga tcagccgggt ggaggcagag gatctgggcg tgtactattg tttccagggc      780

tcccacgtgc cacgcacctt tggcggcggc acaaagctgg agatcaagga tgtgaagagc      840

gcctccgaga gaccttctaa ggacgagatg gccagccggc catggctgct gtacagactg      900

ctgccactgg gaggactgcc tctgctgatc accacatgct tctgtctgtt ttgctgtctg      960

cggagacacc agggcaagca gaacgagctg tccgataccg ccggcaggga gatcaatctg     1020

gtggacgccc acctgaagtc tgagcagacc gaggccagca cacgccagaa ctcccaggtg     1080

ctgctgtctg agacaggcat ctacgacaat gatcccgacc tgtgcttccg gatgcaggag     1140

ggctctgagg tgtacagcaa cccatgtctg gaggagaata agcccggcat cgtgtatgcc     1200

tccctgaacc actctgtgat cggacccaac tccaggctgg ccaggaatgt gaaggaggcc     1260

cctaccgagt atgccagcat ctgcgtgcgg tcctga                               1296


<210>  15
<211>  1188
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  artificial construct

<400>  15
atggcactgc cagtgaccgc cctgctgctg cctctggccc tgctgctgca cgcagccaga       60

cccgagcaga agctgatctc cgaggaggac ctgcaggtgc agctgcagca gtctggacct      120

gagctggtga agccaggagc ctccgtgaag atgtcttgca aggccagcgg ctacaccttc      180

acatcttatc acatccagtg ggtgaagcag cggcccggac agggcctgga gtggatcgga      240

tggatctacc caggcgacgg ctccacacag tataacgaga agttcaaggg caagaccaca      300

ctgaccgccg ataagagcag cagcaccgcc tacatgctgc tgagcagcct gaccagcgag      360

gacagcgcca tctacttttg cgccagggag ggcacatact atgctatgga ctattggggc      420

cagggcacca gcgtgacagt gtctagcgga ggaggaggct ccggaggagg aggctctggc      480

ggcggcggca gcgacgtgct gatgacccag acaccactga gcctgcccgt gagcctgggc      540

gatcaggtga gcatctcctg tagatcctct cagagcatcg tgcactccaa cggcaatacc      600

tacctggagt ggtatctgca gaagccaggc cagtccccca agctgctgat ctataaggtg      660

tctaatcggt tcagcggcgt gcctgacaga ttttctggca gcggctccgg caccgacttc      720

accctgaaga tcagccgggt ggaggcagag gatctgggcg tgtactattg tttccagggc      780

tcccacgtgc cacgcacctt tggcggcggc acaaagctgg agatcaagtc tccaaccgag      840

cccagctcca agacaggcaa cccaaggcac ctgcacatcc tgatcggcac cagcgtggtc      900

atcatcctgt tcatcctgct gttctttctg ctgcaccgct ggtgcagcaa caagaagaat      960

gccgccgtga tggaccagga gtccgccggc aacaggacag ccaattccga ggactctgat     1020

gagcaggacc cccaggaggt gacctacaca cagctgaacc actgcgtgtt tacccagcgg     1080

aagatcacaa gaccttccca gaggccaaag acccccccta cagacatcat cgtgtatgcc     1140

gagctgccca atgccgagtc tcggagcaag gtggtgtctt gtccttga                  1188


<210>  16
<211>  1167
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  artificial construct

<400>  16
atggcactgc cagtgaccgc cctgctgctg cctctggccc tgctgctgca cgcagccaga       60

cccgagcaga agctgatctc cgaggaggac ctgcaggtgc agctgcagca gtctggacct      120

gagctggtga agccaggagc ctccgtgaag atgtcttgca aggccagcgg ctacaccttc      180

acatcttatc acatccagtg ggtgaagcag cggcccggac agggcctgga gtggatcgga      240

tggatctacc caggcgacgg ctccacacag tataacgaga agttcaaggg caagaccaca      300

ctgaccgccg ataagagcag cagcaccgcc tacatgctgc tgagcagcct gaccagcgag      360

gacagcgcca tctacttttg cgccagggag ggcacatact atgctatgga ctattggggc      420

cagggcacca gcgtgacagt gtctagcgga ggaggaggct ccggaggagg aggctctggc      480

ggcggcggca gcgacgtgct gatgacccag acaccactga gcctgcccgt gagcctgggc      540

gatcaggtga gcatctcctg tagatcctct cagagcatcg tgcactccaa cggcaatacc      600

tacctggagt ggtatctgca gaagccaggc cagtccccca agctgctgat ctataaggtg      660

tctaatcggt tcagcggcgt gcctgacaga ttttctggca gcggctccgg caccgacttc      720

accctgaaga tcagccgggt ggaggcagag gatctgggcg tgtactattg tttccagggc      780

tcccacgtgc cacgcacctt tggcggcggc acaaagctgg agatcaagtc tccaaccgag      840

cccagctccg agacaggcaa ccctaggcac ctgcacgtgc tgatcggcac cagcgtggtc      900

atcatcctgt tcatcctgct gctgttcttt ctgctgcacc ggtggtgctg taacaagaag      960

aatgcagtgg tcatggacca ggagccagcc ggcaacagga ccgtgaatag agaggactcc     1020

gatgagcagg acccccagga ggtgacatac gcccagctga accactgcgt gtttacccag     1080

aggaagatca cacgcccttc tcagcggcca aagacccccc ctacagacat catcgtgtat     1140

acagagctgc ccaatgccga gccttga                                         1167


<210>  17
<211>  1224
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  artificial construct

<400>  17
atggcactgc cagtgaccgc cctgctgctg cctctggccc tgctgctgca cgcagccaga       60

cccgagcaga agctgatctc cgaggaggac ctgcaggtgc agctgcagca gtctggacct      120

gagctggtga agccaggagc ctccgtgaag atgtcttgca aggccagcgg ctacaccttc      180

acatcttatc acatccagtg ggtgaagcag cggcccggac agggcctgga gtggatcgga      240

tggatctacc caggcgacgg ctccacacag tataacgaga agttcaaggg caagaccaca      300

ctgaccgccg ataagagcag cagcaccgcc tacatgctgc tgagcagcct gaccagcgag      360

gacagcgcca tctacttttg cgccagggag ggcacatact atgctatgga ctattggggc      420

cagggcacca gcgtgacagt gtctagcgga ggaggaggct ccggaggagg aggctctggc      480

ggcggcggca gcgacgtgct gatgacccag acaccactga gcctgcccgt gagcctgggc      540

gatcaggtga gcatctcctg tagatcctct cagagcatcg tgcactccaa cggcaatacc      600

tacctggagt ggtatctgca gaagccaggc cagtccccca agctgctgat ctataaggtg      660

tctaatcggt tcagcggcgt gcctgacaga ttttctggca gcggctccgg caccgacttc      720

accctgaaga tcagccgggt ggaggcagag gatctgggcg tgtactattg tttccagggc      780

tcccacgtgc cacgcacctt tggcggcggc acaaagctgg agatcaagac cgagaggaga      840

gcagaggtgc ccacagcaca cccatctcca agccctaggc cagcaggaca gttccagacc      900

ctggtggtgg gagtggtggg aggcctgctg ggctctctgg tgctgctggt gtgggtgctg      960

gccgtgatcc accgctggtg ctccaacaag aagaatgccg ccgtgatgga ccaggagtct     1020

gccggcaaca ggaccgccaa ttctgaggac agcgatgagc aggaccccca ggaggtgacc     1080

tacacacagc tgaaccactg cgtgttcacc cagcggaaga tcacaagacc aagccagagg     1140

cccaagaccc cccctacaga catcatcgtg tatgccgagc tgcctaatgc cgagagcagg     1200

tccaaggtgg tgtcctgtcc atga                                            1224


<210>  18
<211>  1305
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  artificial construct

<400>  18
atggcactgc cagtgaccgc cctgctgctg cctctggccc tgctgctgca cgcagccaga       60

cccgagcaga agctgatctc cgaggaggac ctgcaggtgc agctgcagca gtctggacct      120

gagctggtga agccaggagc ctccgtgaag atgtcttgca aggccagcgg ctacaccttc      180

acatcttatc acatccagtg ggtgaagcag cggcccggac agggcctgga gtggatcgga      240

tggatctacc caggcgacgg ctccacacag tataacgaga agttcaaggg caagaccaca      300

ctgaccgccg ataagagcag cagcaccgcc tacatgctgc tgagcagcct gaccagcgag      360

gacagcgcca tctacttttg cgccagggag ggcacatact atgctatgga ctattggggc      420

cagggcacca gcgtgacagt gtctagcgga ggaggaggct ccggaggagg aggctctggc      480

ggcggcggca gcgacgtgct gatgacccag acaccactga gcctgcccgt gagcctgggc      540

gatcaggtga gcatctcctg tagatcctct cagagcatcg tgcactccaa cggcaatacc      600

tacctggagt ggtatctgca gaagccaggc cagtccccca agctgctgat ctataaggtg      660

tctaatcggt tcagcggcgt gcctgacaga ttttctggca gcggctccgg caccgacttc      720

accctgaaga tcagccgggt ggaggcagag gatctgggcg tgtactattg tttccagggc      780

tcccacgtgc cacgcacctt tggcggcggc acaaagctgg agatcaagac cgagaggaga      840

gcagaggtgc ccacagcaca cccatctcca agccctaggc cagcaggaca gttccagacc      900

ctggtggtgg gagtggtggg aggcctgctg ggctctctgg tgctgctggt gtgggtgctg      960

gccgtgatcc ggagacacca gggcaagcag aacgagctga gcgataccgc cggccgggag     1020

atcaatctgg tggacgccca cctgaagtcc gagcagaccg aggcctccac aagacagaac     1080

tctcaggtgc tgctgagcga gacaggcatc tacgacaatg atcccgacct gtgcttcagg     1140

atgcaggagg gcagcgaggt gtactccaac ccctgtctgg aggagaataa gcctggcatc     1200

gtgtatgcct ctctgaacca cagcgtgatc ggcccaaact ctaggctggc ccgcaatgtg     1260

aaggaggccc ccaccgagta tgcctccatc tgcgtgaggt cttga                     1305


<210>  19
<211>  1095
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  artificial construct

<400>  19
atggcactgc cagtgaccgc cctgctgctg cctctggccc tgctgctgca cgcagccaga       60

cccgagcaga agctgatctc cgaggaggac ctgcaggtgc agctgcagca gtctggacct      120

gagctggtga agccaggagc ctccgtgaag atgtcttgca aggccagcgg ctacaccttc      180

acatcttatc acatccagtg ggtgaagcag cggcccggac agggcctgga gtggatcgga      240

tggatctacc caggcgacgg ctccacacag tataacgaga agttcaaggg caagaccaca      300

ctgaccgccg ataagagcag cagcaccgcc tacatgctgc tgagcagcct gaccagcgag      360

gacagcgcca tctacttttg cgccagggag ggcacatact atgctatgga ctattggggc      420

cagggcacca gcgtgacagt gtctagcgga ggaggaggct ccggaggagg aggctctggc      480

ggcggcggca gcgacgtgct gatgacccag acaccactga gcctgcccgt gagcctgggc      540

gatcaggtga gcatctcctg tagatcctct cagagcatcg tgcactccaa cggcaatacc      600

tacctggagt ggtatctgca gaagccaggc cagtccccca agctgctgat ctataaggtg      660

tctaatcggt tcagcggcgt gcctgacaga ttttctggca gcggctccgg caccgacttc      720

accctgaaga tcagccgggt ggaggcagag gatctgggcg tgtactattg tttccagggc      780

tcccacgtgc cacgcacctt tggcggcggc acaaagctgg agatcaagac cgagaggaga      840

gcagaggtgc ccacagcaca cccatctcca agccctaggc cagcaggaca gttccagacc      900

ctggtggtgg gagtggtggg aggcctgctg ggctctctgg tgctgctggt gtgggtgctg      960

gccgtgatcg ccgtgagcct gtccaagatg ctgaagaagc ggtctcctct gaccacaggc     1020

gtgggcgtga agatgccccc taccgagccc gagtgcgaga agcagttcca gccatacttt     1080

atccccatca actga                                                      1095


<210>  20
<211>  1737
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  artificial construct

<400>  20
atggcactgc cagtgaccgc cctgctgctg cctctggccc tgctgctgca cgcagccaga       60

cccgagcaga agctgatctc cgaggaggac ctgcaggtgc agctgcagca gtctggacct      120

gagctggtga agccaggagc ctccgtgaag atgtcttgca aggccagcgg ctacaccttc      180

acatcttatc acatccagtg ggtgaagcag cggcccggac agggcctgga gtggatcgga      240

tggatctacc caggcgacgg ctccacacag tataacgaga agttcaaggg caagaccaca      300

ctgaccgccg ataagagcag cagcaccgcc tacatgctgc tgagcagcct gaccagcgag      360

gacagcgcca tctacttttg cgccagggag ggcacatact atgctatgga ctattggggc      420

cagggcacca gcgtgacagt gtctagcgga ggaggaggct ccggaggagg aggctctggc      480

ggcggcggca gcgacgtgct gatgacccag acaccactga gcctgcccgt gagcctgggc      540

gatcaggtga gcatctcctg tagatcctct cagagcatcg tgcactccaa cggcaatacc      600

tacctggagt ggtatctgca gaagccaggc cagtccccca agctgctgat ctataaggtg      660

tctaatcggt tcagcggcgt gcctgacaga ttttctggca gcggctccgg caccgacttc      720

accctgaaga tcagccgggt ggaggcagag gatctgggcg tgtactattg tttccagggc      780

tcccacgtgc cacgcacctt tggcggcggc acaaagctgg agatcaagac cgagaggaga      840

gcagaggtgc ccacagcaca cccatctcca agccctaggc cagcaggaca gttccagacc      900

ctggtggtgg gagtggtggg aggcctgctg ggctctctgg tgctgctggt gtgggtgctg      960

gccgtgatcc tgaagctgct ccagaccatc ggcaagggcg agttcggcga cgtgatgctg     1020

ggcgattaca gaggcaacaa ggtggccgtg aagtgcatca agaatgacgc aaccgcacag     1080

gcctttctgg cagaggccag cgtgatgaca cagctgaggc actccaacct ggtgcagctg     1140

ctgggcgtga tcgtggagga gaagggcggc ctgtacatcg tgacagagta tatggccaag     1200

ggcagcctgg tggactacct gcggtccaga ggcaggtctg tgctgggagg cgactgcctg     1260

ctgaagttca gcctggacgt gtgcgaggcc atggagtatc tggagggcaa caattttgtg     1320

caccgcgatc tggcagcaag gaacgtgctg gtgtctgagg acaatgtggc caaggtgagc     1380

gatttcggcc tgaccaagga ggccagctcc acccaggaca caggcaagct gcctgtgaag     1440

tggaccgcac cagaggccct gagggagaag aagttctcta caaagagcga cgtgtggtcc     1500

tttggcatcc tgctgtggga aatctactct tttggcagag tgccatatcc cagaatcccc     1560

ctgaaggacg tggtgcctcg ggtggagaag ggctacaaga tggacgcacc agatggatgc     1620

ccacctgccg tgtatgaagt gatgaagaat tgttggcacc tggatgcagc aatgaggccc     1680

agcttcctcc agctgaggga gcagctggag cacatcaaga cacacgagct gcactga        1737


<210>  21
<211>  1431
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  artificial construct

<400>  21
atggcactgc cagtgaccgc cctgctgctg cctctggccc tgctgctgca cgcagccaga       60

cccgagcaga agctgatctc cgaggaggac ctgcaggtgc agctgcagca gtctggacct      120

gagctggtga agccaggagc ctccgtgaag atgtcttgca aggccagcgg ctacaccttc      180

acatcttatc acatccagtg ggtgaagcag cggcccggac agggcctgga gtggatcgga      240

tggatctacc caggcgacgg ctccacacag tataacgaga agttcaaggg caagaccaca      300

ctgaccgccg ataagagcag cagcaccgcc tacatgctgc tgagcagcct gaccagcgag      360

gacagcgcca tctacttttg cgccagggag ggcacatact atgctatgga ctattggggc      420

cagggcacca gcgtgacagt gtctagcgga ggaggaggct ccggaggagg aggctctggc      480

ggcggcggca gcgacgtgct gatgacccag acaccactga gcctgcccgt gagcctgggc      540

gatcaggtga gcatctcctg tagatcctct cagagcatcg tgcactccaa cggcaatacc      600

tacctggagt ggtatctgca gaagccaggc cagtccccca agctgctgat ctataaggtg      660

tctaatcggt tcagcggcgt gcctgacaga ttttctggca gcggctccgg caccgacttc      720

accctgaaga tcagccgggt ggaggcagag gatctgggcg tgtactattg tttccagggc      780

tcccacgtgc cacgcacctt tggcggcggc acaaagctgg agatcaagac cgagaggaga      840

gcagaggtgc ccacagcaca cccatctcca agccctaggc cagcaggaca gttccagacc      900

ctggtggtgg gagtggtggg aggcctgctg ggctctctgg tgctgctggt gtgggtgctg      960

gccgtgatct gcagcagggc cgcccgcggc accatcggcg ccaggcgcac aggccagcct     1020

ctgaaggagg acccttccgc cgtgccagtg ttctctgtgg actacggcga gctggatttt     1080

cagtggcggg agaaaacccc agagccacct gtgccctgcg tgcctgagca gaccgagtat     1140

gccacaatcg tgtttccatc cggaatgggc acaagctccc ctgcaaggag aggcagcgcc     1200

gacggaccac ggtccgccca gccactgcgg cccgaggatg gccactgttc ttggcccctg     1260

ggtggcggtg gctcgggcgg tggtgggtcg ggtggcggcg gatctgccgt gagcctgtcc     1320

aagatgctga agaagcggtc tcctctgacc acaggcgtgg gcgtgaagat gccccctacc     1380

gagcccgagt gcgagaagca gttccagcca tactttatcc ccatcaactg a              1431


<210>  22
<211>  1470
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  artificial construct

<400>  22
atggcactgc cagtgaccgc cctgctgctg cctctggccc tgctgctgca cgcagccaga       60

cccgagcaga agctgatctc cgaggaggac ctgcaggtgc agctgcagca gtctggacct      120

gagctggtga agccaggagc ctccgtgaag atgtcttgca aggccagcgg ctacaccttc      180

acatcttatc acatccagtg ggtgaagcag cggcccggac agggcctgga gtggatcgga      240

tggatctacc caggcgacgg ctccacacag tataacgaga agttcaaggg caagaccaca      300

ctgaccgccg ataagagcag cagcaccgcc tacatgctgc tgagcagcct gaccagcgag      360

gacagcgcca tctacttttg cgccagggag ggcacatact atgctatgga ctattggggc      420

cagggcacca gcgtgacagt gtctagcgga ggaggaggct ccggaggagg aggctctggc      480

ggcggcggca gcgacgtgct gatgacccag acaccactga gcctgcccgt gagcctgggc      540

gatcaggtga gcatctcctg tagatcctct cagagcatcg tgcactccaa cggcaatacc      600

tacctggagt ggtatctgca gaagccaggc cagtccccca agctgctgat ctataaggtg      660

tctaatcggt tcagcggcgt gcctgacaga ttttctggca gcggctccgg caccgacttc      720

accctgaaga tcagccgggt ggaggcagag gatctgggcg tgtactattg tttccagggc      780

tcccacgtgc cacgcacctt tggcggcggc acaaagctgg agatcaagac cgagaggaga      840

gcagaggtgc ccacagcaca cccatctcca agccctaggc cagcaggaca gttccagacc      900

ctggtggtgg gagtggtggg aggcctgctg ggctctctgg tgctgctggt gtgggtgctg      960

gccgtgatct gcagcagggc cgcccgcggc accatcggcg ccaggcgcac aggccagcct     1020

ctgaaggagg acccttccgc cgtgccagtg ttctctgtgg actacggcga gctggatttt     1080

cagtggcggg agaaaacccc agagccacct gtgccctgcg tgcctgagca gaccgagtat     1140

gccacaatcg tgtttccatc cggaatgggc acaagctccc ctgcaaggag aggcagcgcc     1200

gacggaccac ggtccgccca gccactgcgg cccgaggatg gccactgttc ttggcccctg     1260

ggtggcggtg gctcgggcgg tggtgggtcg ggtggcggcg gatctcacct gtggcggaga     1320

cagtggcggc ccaggcgctt cagcgccctg gagcagggca tccacccacc tcaggcacag     1380

tccaagatcg aggagctgga gcaggagcca gagccagagc ctgaacctga gccagagcct     1440

gaacccgagc cagagcctga gcagctgtga                                      1470


<210>  23
<211>  1668
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  artificial construct

<400>  23
atggcactgc cagtgaccgc cctgctgctg cctctggccc tgctgctgca cgcagccaga       60

cccgagcaga agctgatctc cgaggaggac ctgcaggtgc agctgcagca gtctggacct      120

gagctggtga agccaggagc ctccgtgaag atgtcttgca aggccagcgg ctacaccttc      180

acatcttatc acatccagtg ggtgaagcag cggcccggac agggcctgga gtggatcgga      240

tggatctacc caggcgacgg ctccacacag tataacgaga agttcaaggg caagaccaca      300

ctgaccgccg ataagagcag cagcaccgcc tacatgctgc tgagcagcct gaccagcgag      360

gacagcgcca tctacttttg cgccagggag ggcacatact atgctatgga ctattggggc      420

cagggcacca gcgtgacagt gtctagcgga ggaggaggct ccggaggagg aggctctggc      480

ggcggcggca gcgacgtgct gatgacccag acaccactga gcctgcccgt gagcctgggc      540

gatcaggtga gcatctcctg tagatcctct cagagcatcg tgcactccaa cggcaatacc      600

tacctggagt ggtatctgca gaagccaggc cagtccccca agctgctgat ctataaggtg      660

tctaatcggt tcagcggcgt gcctgacaga ttttctggca gcggctccgg caccgacttc      720

accctgaaga tcagccgggt ggaggcagag gatctgggcg tgtactattg tttccagggc      780

tcccacgtgc cacgcacctt tggcggcggc acaaagctgg agatcaagac cgagaggaga      840

gcagaggtgc ccacagcaca cccatctcca agccctaggc cagcaggaca gttccagacc      900

ctggtggtgg gagtggtggg aggcctgctg ggctctctgg tgctgctggt gtgggtgctg      960

gccgtgatct gcagcagggc cgcccgcggc accatcggcg ccaggcgcac aggccagcct     1020

ctgaaggagg acccttccgc cgtgccagtg ttctctgtgg actacggcga gctggatttt     1080

cagtggcggg agaaaacccc agagccacct gtgccctgcg tgcctgagca gaccgagtat     1140

gccacaatcg tgtttccatc cggaatgggc acaagctccc ctgcaaggag aggcagcgcc     1200

gacggaccac ggtccgccca gccactgcgg cccgaggatg gccactgttc ttggcccctg     1260

ggtggcggtg gctcgggcgg tggtgggtcg ggtggcggcg gatcttggcg gagaaagcgg     1320

aaggagaagc agagcgagac ctcccccaag gagttcctga caatctacga ggacgtgaag     1380

gatctgaaga ccaggcgcaa ccacgagcag gagcagacct ttcctggcgg cggctctaca     1440

atctatagca tgatccagtc ccagagcagc gcccccacct ctcaggagcc tgcctacaca     1500

ctgtattctc tgatccagcc tagccggaag tctggcagcc ggaagagaaa ccactcccca     1560

tctttcaatt ccacaatcta cgaagtgatc ggcaagtctc agccaaaggc acagaaccca     1620

gcaaggctga gccgcaagga gctggagaat tttgacgtgt attcctga                  1668


<210>  24
<211>  1647
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  artificial construct

<400>  24
atggcactgc cagtgaccgc cctgctgctg cctctggccc tgctgctgca cgcagccaga       60

cccgagcaga agctgatctc cgaggaggac ctgcaggtgc agctgcagca gtctggacct      120

gagctggtga agccaggagc ctccgtgaag atgtcttgca aggccagcgg ctacaccttc      180

acatcttatc acatccagtg ggtgaagcag cggcccggac agggcctgga gtggatcgga      240

tggatctacc caggcgacgg ctccacacag tataacgaga agttcaaggg caagaccaca      300

ctgaccgccg ataagagcag cagcaccgcc tacatgctgc tgagcagcct gaccagcgag      360

gacagcgcca tctacttttg cgccagggag ggcacatact atgctatgga ctattggggc      420

cagggcacca gcgtgacagt gtctagcgga ggaggaggct ccggaggagg aggctctggc      480

ggcggcggca gcgacgtgct gatgacccag acaccactga gcctgcccgt gagcctgggc      540

gatcaggtga gcatctcctg tagatcctct cagagcatcg tgcactccaa cggcaatacc      600

tacctggagt ggtatctgca gaagccaggc cagtccccca agctgctgat ctataaggtg      660

tctaatcggt tcagcggcgt gcctgacaga ttttctggca gcggctccgg caccgacttc      720

accctgaaga tcagccgggt ggaggcagag gatctgggcg tgtactattg tttccagggc      780

tcccacgtgc cacgcacctt tggcggcggc acaaagctgg agatcaagac cgagaggaga      840

gcagaggtgc ccacagcaca cccatctcca agccctaggc cagcaggaca gttccagacc      900

ctggtggtgg gagtggtggg aggcctgctg ggctctctgg tgctgctggt gtgggtgctg      960

gccgtgatct gcagcagggc cgcccgcggc accatcggcg ccaggcgcac aggccagcct     1020

ctgaaggagg acccttccgc cgtgccagtg ttctctgtgg actacggcga gctggatttt     1080

cagtggcggg agaaaacccc agagccacct gtgccctgcg tgcctgagca gaccgagtat     1140

gccacaatcg tgtttccatc cggaatgggc acaagctccc ctgcaaggag aggcagcgcc     1200

gacggaccac ggtccgccca gccactgcgg cccgaggatg gccactgttc ttggcccctg     1260

ggtggcggtg gctcgggcgg tggtgggtcg ggtggcggcg gatcttggcg gatgatgaag     1320

taccagcaga aggccgccgg aatgtctcca gagcaggtgc tccagcccct ggagggcgac     1380

ctgtgctatg ccgacctgac cctccagctg gccggcacaa gcccacagaa ggcaaccaca     1440

aagctgagca gcgcccaggt ggaccaggtg gaggtggagt acgtgaccat ggcctccctg     1500

cctaaggagg acatctccta tgcctctctg accctgggcg ccgaggatca ggagcctaca     1560

tactgtaaca tgggccacct gtctagccac ctgccaggaa ggggaccaga ggagcctacc     1620

gagtatagca caatctccag accctga                                         1647


<210>  25
<211>  1431
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  artificial construct

<400>  25
atggcactgc cagtgaccgc cctgctgctg cctctggccc tgctgctgca cgcagccaga       60

cccgagcaga agctgatctc cgaggaggac ctgcaggtgc agctgcagca gtctggacct      120

gagctggtga agccaggagc ctccgtgaag atgtcttgca aggccagcgg ctacaccttc      180

acatcttatc acatccagtg ggtgaagcag cggcccggac agggcctgga gtggatcgga      240

tggatctacc caggcgacgg ctccacacag tataacgaga agttcaaggg caagaccaca      300

ctgaccgccg ataagagcag cagcaccgcc tacatgctgc tgagcagcct gaccagcgag      360

gacagcgcca tctacttttg cgccagggag ggcacatact atgctatgga ctattggggc      420

cagggcacca gcgtgacagt gtctagcgga ggaggaggct ccggaggagg aggctctggc      480

ggcggcggca gcgacgtgct gatgacccag acaccactga gcctgcccgt gagcctgggc      540

gatcaggtga gcatctcctg tagatcctct cagagcatcg tgcactccaa cggcaatacc      600

tacctggagt ggtatctgca gaagccaggc cagtccccca agctgctgat ctataaggtg      660

tctaatcggt tcagcggcgt gcctgacaga ttttctggca gcggctccgg caccgacttc      720

accctgaaga tcagccgggt ggaggcagag gatctgggcg tgtactattg tttccagggc      780

tcccacgtgc cacgcacctt tggcggcggc acaaagctgg agatcaagac cgagaggaga      840

gcagaggtgc ccacagcaca cccatctcca agccctaggc cagcaggaca gttccagacc      900

ctggtggtgg gagtggtggg aggcctgctg ggctctctgg tgctgctggt gtgggtgctg      960

gccgtgatct gcagcagggc cgcccgcggc accatcggcg ccaggcgcac aggccagcct     1020

ctgaaggagg acccttccgc cgtgccagtg ttctctgtgg actacggcga gctggatttt     1080

cagtggcggg agaaaacccc agagccacct gtgccctgcg tgcctgagca gaccgagtat     1140

gccacaatcg tgtttccatc cggaatgggc acaagctccc ctgcaaggag aggcagcgcc     1200

gacggaccac ggtccgccca gccactgcgg cccgaggatg gccactgttc ttggcccctg     1260

ggtggcggtg gctcgggcgg tggtgggtcg ggtggcggcg gatctgccgt gagcctgtcc     1320

aagatgctga agaagcggtc tcctctgacc acaggcgtgg gcgtgaagat gccccctacc     1380

gagcccgagt gcgagaagca gttccagcca tactttatcc ccatcaactg a              1431


<210>  26
<211>  1611
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  artificial construct

<400>  26
atggcactgc cagtgaccgc cctgctgctg cctctggccc tgctgctgca cgcagccaga       60

cccgagcaga agctgatctc cgaggaggac ctgcaggtgc agctgcagca gtctggacct      120

gagctggtga agccaggagc ctccgtgaag atgtcttgca aggccagcgg ctacaccttc      180

acatcttatc acatccagtg ggtgaagcag cggcccggac agggcctgga gtggatcgga      240

tggatctacc caggcgacgg ctccacacag tataacgaga agttcaaggg caagaccaca      300

ctgaccgccg ataagagcag cagcaccgcc tacatgctgc tgagcagcct gaccagcgag      360

gacagcgcca tctacttttg cgccagggag ggcacatact atgctatgga ctattggggc      420

cagggcacca gcgtgacagt gtctagcgga ggaggaggct ccggaggagg aggctctggc      480

ggcggcggca gcgacgtgct gatgacccag acaccactga gcctgcccgt gagcctgggc      540

gatcaggtga gcatctcctg tagatcctct cagagcatcg tgcactccaa cggcaatacc      600

tacctggagt ggtatctgca gaagccaggc cagtccccca agctgctgat ctataaggtg      660

tctaatcggt tcagcggcgt gcctgacaga ttttctggca gcggctccgg caccgacttc      720

accctgaaga tcagccgggt ggaggcagag gatctgggcg tgtactattg tttccagggc      780

tcccacgtgc cacgcacctt tggcggcggc acaaagctgg agatcaagac cgagaggaga      840

gcagaggtgc ccacagcaca cccatctcca agccctaggc cagcaggaca gttccagacc      900

ctggtggtgg gagtggtggg aggcctgctg ggctctctgg tgctgctggt gtgggtgctg      960

gccgtgatct gcagcagggc cgcccgcggc accatcggcg ccaggcgcac aggccagcct     1020

ctgaaggagg acccttccgc cgtgccagtg ttctctgtgg actacggcga gctggatttt     1080

cagtggcggg agaaaacccc agagccacct gtgccctgcg tgcctgagca gaccgagtat     1140

gccacaatcg tgtttccatc cggaatgggc acaagctccc ctgcaaggag aggcagcgcc     1200

gacggaccac ggtccgccca gccactgcgg cccgaggatg gccactgttc ttggcccctg     1260

ggtggcggtg gctcgggcgg tggtgggtcg ggtggcggcg gatctcacag gcagaaccag     1320

atcaagcagg gaccacctcg cagcaaggac gaggagcaga agccacagca gaggcccgac     1380

ctggcagtgg atgtgctgga gagaaccgcc gataaggcca cagtgaatgg cctgcccgag     1440

aaggacaggg agaccgatac atccgccctg gccgccggca gctcccagga ggtgacctac     1500

gcccagctgg accactgggc actgacccag aggacagcca gagccgtgtc tcctcagagc     1560

accaagccaa tggccgagtc tatcacctac gccgccgtgg ccagacactg a              1611


<210>  27
<211>  1554
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  artificial construct

<400>  27
atggcactgc cagtgaccgc cctgctgctg cctctggccc tgctgctgca cgcagccaga       60

cccgagcaga agctgatctc cgaggaggac ctgcaggtgc agctgcagca gtctggacct      120

gagctggtga agccaggagc ctccgtgaag atgtcttgca aggccagcgg ctacaccttc      180

acatcttatc acatccagtg ggtgaagcag cggcccggac agggcctgga gtggatcgga      240

tggatctacc caggcgacgg ctccacacag tataacgaga agttcaaggg caagaccaca      300

ctgaccgccg ataagagcag cagcaccgcc tacatgctgc tgagcagcct gaccagcgag      360

gacagcgcca tctacttttg cgccagggag ggcacatact atgctatgga ctattggggc      420

cagggcacca gcgtgacagt gtctagcgga ggaggaggct ccggaggagg aggctctggc      480

ggcggcggca gcgacgtgct gatgacccag acaccactga gcctgcccgt gagcctgggc      540

gatcaggtga gcatctcctg tagatcctct cagagcatcg tgcactccaa cggcaatacc      600

tacctggagt ggtatctgca gaagccaggc cagtccccca agctgctgat ctataaggtg      660

tctaatcggt tcagcggcgt gcctgacaga ttttctggca gcggctccgg caccgacttc      720

accctgaaga tcagccgggt ggaggcagag gatctgggcg tgtactattg tttccagggc      780

tcccacgtgc cacgcacctt tggcggcggc acaaagctgg agatcaagac cgagaggaga      840

gcagaggtgc ccacagcaca cccatctcca agccctaggc cagcaggaca gttccagacc      900

ctggtggtgg gagtggtggg aggcctgctg ggctctctgg tgctgctggt gtgggtgctg      960

gccgtgatct gcagcagggc cgcccgcggc accatcggcg ccaggcgcac aggccagcct     1020

ctgaaggagg acccttccgc cgtgccagtg ttctctgtgg actacggcga gctggatttt     1080

cagtggcggg agaaaacccc agagccacct gtgccctgcg tgcctgagca gaccgagtat     1140

gccacaatcg tgtttccatc cggaatgggc acaagctccc ctgcaaggag aggcagcgcc     1200

gacggaccac ggtccgccca gccactgcgg cccgaggatg gccactgttc ttggcccctg     1260

ggtggcggtg gctcgggcgg tggtgggtcg ggtggcggcg gatctctgac ccggaagaag     1320

aaggccctgc gcatccacag cgtggagggc gacctgagga gaaagtccgc cggccaggag     1380

gagtggagcc catccgcccc ctccccccct ggctcttgcg tgcaggcaga ggcagcacct     1440

gccggcctgt gcggcgagca gcggggcgag gactgtgccg agctgcacga ttacttcaac     1500

gtgctgtctt ataggagcct gggcaattgt tctttcttta ccgagacagg ctga           1554


<210>  28
<211>  1596
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  artificial construct

<400>  28
atggcactgc cagtgaccgc cctgctgctg cctctggccc tgctgctgca cgcagccaga       60

cccgagcaga agctgatctc cgaggaggac ctgcaggtgc agctgcagca gtctggacct      120

gagctggtga agccaggagc ctccgtgaag atgtcttgca aggccagcgg ctacaccttc      180

acatcttatc acatccagtg ggtgaagcag cggcccggac agggcctgga gtggatcgga      240

tggatctacc caggcgacgg ctccacacag tataacgaga agttcaaggg caagaccaca      300

ctgaccgccg ataagagcag cagcaccgcc tacatgctgc tgagcagcct gaccagcgag      360

gacagcgcca tctacttttg cgccagggag ggcacatact atgctatgga ctattggggc      420

cagggcacca gcgtgacagt gtctagcgga ggaggaggct ccggaggagg aggctctggc      480

ggcggcggca gcgacgtgct gatgacccag acaccactga gcctgcccgt gagcctgggc      540

gatcaggtga gcatctcctg tagatcctct cagagcatcg tgcactccaa cggcaatacc      600

tacctggagt ggtatctgca gaagccaggc cagtccccca agctgctgat ctataaggtg      660

tctaatcggt tcagcggcgt gcctgacaga ttttctggca gcggctccgg caccgacttc      720

accctgaaga tcagccgggt ggaggcagag gatctgggcg tgtactattg tttccagggc      780

tcccacgtgc cacgcacctt tggcggcggc acaaagctgg agatcaagac cgagaggaga      840

gcagaggtgc ccacagcaca cccatctcca agccctaggc cagcaggaca gttccagacc      900

ctggtggtgg gagtggtggg aggcctgctg ggctctctgg tgctgctggt gtgggtgctg      960

gccgtgatct gcagcagggc cgcccgcggc accatcggcg ccaggcgcac aggccagcct     1020

ctgaaggagg acccttccgc cgtgccagtg ttctctgtgg actacggcga gctggatttt     1080

cagtggcggg agaaaacccc agagccacct gtgccctgcg tgcctgagca gaccgagtat     1140

gccacaatcg tgtttccatc cggaatgggc acaagctccc ctgcaaggag aggcagcgcc     1200

gacggaccac ggtccgccca gccactgcgg cccgaggatg gccactgttc ttggcccctg     1260

ggtggcggtg gctcgggcgg tggtgggtcg ggtggcggcg gatcttacaa gcagaggcag     1320

gcagccagca acaggagagc ccaggagctg gtgaggatgg actccaacat ccagggcatc     1380

gagaatccag gattcgaggc ctctccacct gcacagggca tccctgaggc aaaggtgcgg     1440

cacccactga gctatgtggc acagaggcag cctagcgagt ccggccgcca cctgctgtct     1500

gagcccagca cccctctgtc cccaccagga ccaggcgacg tgttcttccc ctccctggac     1560

cctgtgccag attctcccaa ttttgaagtg atctga                               1596


<210>  29
<211>  1845
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  artificial construct

<400>  29
atggcactgc cagtgaccgc cctgctgctg cctctggccc tgctgctgca cgcagccaga       60

cccgagcaga agctgatctc cgaggaggac ctgcaggtgc agctgcagca gtctggacct      120

gagctggtga agccaggagc ctccgtgaag atgtcttgca aggccagcgg ctacaccttc      180

acatcttatc acatccagtg ggtgaagcag cggcccggac agggcctgga gtggatcgga      240

tggatctacc caggcgacgg ctccacacag tataacgaga agttcaaggg caagaccaca      300

ctgaccgccg ataagagcag cagcaccgcc tacatgctgc tgagcagcct gaccagcgag      360

gacagcgcca tctacttttg cgccagggag ggcacatact atgctatgga ctattggggc      420

cagggcacca gcgtgacagt gtctagcgga ggaggaggct ccggaggagg aggctctggc      480

ggcggcggca gcgacgtgct gatgacccag acaccactga gcctgcccgt gagcctgggc      540

gatcaggtga gcatctcctg tagatcctct cagagcatcg tgcactccaa cggcaatacc      600

tacctggagt ggtatctgca gaagccaggc cagtccccca agctgctgat ctataaggtg      660

tctaatcggt tcagcggcgt gcctgacaga ttttctggca gcggctccgg caccgacttc      720

accctgaaga tcagccgggt ggaggcagag gatctgggcg tgtactattg tttccagggc      780

tcccacgtgc cacgcacctt tggcggcggc acaaagctgg agatcaagac cgagaggaga      840

gcagaggtgc ccacagcaca cccatctcca agccctaggc cagcaggaca gttccagacc      900

ctggtggtgg gagtggtggg aggcctgctg ggctctctgg tgctgctggt gtgggtgctg      960

gccgtgatct gcagcagggc cgcccgcggc accatcggcg ccaggcgcac aggccagcct     1020

ctgaaggagg acccttccgc cgtgccagtg ttctctgtgg actacggcga gctggatttt     1080

cagtggcggg agaaaacccc agagccacct gtgccctgcg tgcctgagca gaccgagtat     1140

gccacaatcg tgtttccatc cggaatgggc acaagctccc ctgcaaggag aggcagcgcc     1200

gacggaccac ggtccgccca gccactgcgg cccgaggatg gccactgttc ttggcccctg     1260

ggtggcggtg gctcgggcgg tggtgggtcg ggtggcggcg gatctaagcg gaagggcaga     1320

tgctccgtgc cagccttctg tagctcccag gcagaggcac ccgccgacac cccagagcct     1380

acagccggcc acaccctgta ctccgtgctg tctcagggct atgagaagct ggatacccca     1440

ctgaggcctg caaggcagca gccaaccccc acaagcgact ctagctccga ttccaacctg     1500

accacagagg aggacgagga tcggcccgag gtgcacaagc ctatctccgg caggtacgag     1560

gtgttcgacc aggtgacaca ggagggagca ggacacgatc ctgcaccaga gggccaggcc     1620

gactacgatc cagtgacacc ctatgtgacc gaggtggagt ctgtggtggg cgagaacacc     1680

atgtacgccc aggtgttcaa cctccagggc aagacacccg tgagccagaa ggaggagtct     1740

agcgccacca tctattgcag catcaggaag ccacaggtgg tgccccctcc acagcagaac     1800

gacctggaga tccctgagag cccaacctac gagaacttca cctga                     1845


<210>  30
<211>  1302
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  artificial construct

<400>  30
atggcactgc cagtgaccgc cctgctgctg cctctggccc tgctgctgca cgcagccaga       60

cccgagcaga agctgatctc cgaggaggac ctggcactgc ctgtgacagc cctgctgctg      120

ccactggccc tgctgctgca cgcagaggtg cagctccagc agagcggacc agagctggtg      180

aagccaggca caagcgtgcg gatctcctgc aagacctctg gctacacctt cacagagtat      240

accatccact gggtgaagca gagccacggc aagtccctgg agtggatcgg caacatcaat      300

cccaacaatg gcggcaccac atacaaccag aagtttgagg acaaggccac cctgacagtg      360

gataagagca gcagcaccgc ctatatggag ctgaggagcc tgacctccga ggactctgcc      420

gtgtactatt gcgccgccgg atggaatttc gattactggg gccagggcac cacagtgacc      480

gtgagcagcg gcggcggcgg ctctggagga ggaggcagcg gcggaggagg ctccgacatc      540

gtgatgacac agtcccacaa gtttatgtct accagcgtgg gcgatcgcgt gtctatcatc      600

tgtaaggcca gccaggacgt gggcaccgcc gtggattggt atcagcagaa gcccggccag      660

tcccctaagc tgctgatcta ttgggcctct acaaggcaca ccggcgtgcc cgacagattc      720

acaggctccg gctctggcac cgacttcacc ctgacaatca ccaacgtgca gagcgaggac      780

ctggccgatt atttctgtca gcagtacaat tcctatcctc tgacatttgg cgccggcacc      840

atgctggacc tgaagagggc tgccgccacc gagaggagag cagaggtgcc cacagcacac      900

ccatctccaa gccctaggcc agcaggacag ttccagaccc tggtggtggg agtggtggga      960

ggcctgctgg gctctctggt gctgctggtg tgggtgctgg ccgtgatctg cagcagggcc     1020

gcccgcggca ccatcggcgc caggcgcaca ggccagcctc tgaaggagga cccttccgcc     1080

gtgccagtgt tctctgtgga ctacggcgag ctggattttc agtggcggga gaaaacccca     1140

gagccacctg tgccctgcgt gcctgagcag accgagtatg ccacaatcgt gtttccatcc     1200

ggaatgggca caagctcccc tgcaaggaga ggcagcgccg acggaccacg gtccgcccag     1260

ccactgcggc ccgaggatgg ccactgttct tggcccctgt ga                        1302


<210>  31
<211>  3338
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  artificial construct

<400>  31
atggcactgc cagtgaccgc cctgctgctg cctctggccc tgctgctgca cgcagccaga       60

cccgagcaga agctgatctc cgaggaggac ctgcaggtgc agctgcagca gtctggacct      120

gagctggtga agccaggagc ctccgtgaag atgtcttgca aggccagcgg ctacaccttc      180

acatcttatc acatccagtg ggtgaagcag cggcccggac agggcctgga gtggatcgga      240

tggatctacc caggcgacgg ctccacacag tataacgaga agttcaaggg caagaccaca      300

ctgaccgccg ataagagcag cagcaccgcc tacatgctgc tgagcagcct gaccagcgag      360

gacagcgcca tctacttttg cgccagggag ggcacatact atgctatgga ctattggggc      420

cagggcacca gcgtgacagt gtctagcgga ggaggaggct ccggaggagg aggctctggc      480

ggcggcggca gcgacgtgct gatgacccag acaccactga gcctgcccgt gagcctgggc      540

gatcaggtga gcatctcctg tagatcctct cagagcatcg tgcactccaa cggcaatacc      600

tacctggagt ggtatctgca gaagccaggc cagtccccca agctgctgat ctataaggtg      660

tctaatcggt tcagcggcgt gcctgacaga ttttctggca gcggctccgg caccgacttc      720

accctgaaga tcagccgggt ggaggcagag gatctgggcg tgtactattg tttccagggc      780

tcccacgtgc cacgcacctt tggcggcggc acaaagctgg agatcaagac cgagaggaga      840

gcagaggtgc ccacagcaca cccatctcca agccctaggc cagcaggaca gttccagacc      900

ctggtggtgg gagtggtggg aggcctgctg ggctctctgg tgctgctggt gtgggtgctg      960

gccgtgatct gcagcagggc cgcccgcggc accatcggcg ccaggcgcac aggccagcct     1020

ctgaaggagg acccttccgc cgtgccagtg ttctctgtgg actacggcga gctggatttt     1080

cagtggcggg agaaaacccc agagccacct gtgccctgcg tgcctgagca gaccgagtat     1140

gccacaatcg tgtttccatc cggaatgggc acaagctccc ctgcaaggag aggcagcgcc     1200

gacggaccac ggtccgccca gccactgcgg cccgaggatg gccactgttc ttggcccctg     1260

tgacccctct ccctcccccc cccctaacgt tactggccga agccgcttgg aataaggccg     1320

gtgtgcgttt gtctatatgt tattttccac catattgccg tcttttggca atgtgagggc     1380

ccggaaacct ggccctgtct tcttgacgag cattcctagg ggtctttccc ctctcgccaa     1440

aggaatgcaa ggtctgttga atgtcgtgaa ggaagcagtt cctctggaag cttcttgaag     1500

acaaacaacg tctgtagcga ccctttgcag gcagcggaac cccccacctg gcgacaggtg     1560

cctctgcggc caaaagccac gtgtataaga tacacctgca aaggcggcac aaccccagtg     1620

ccacgttgtg agttggatag ttgtggaaag agtcaaatgg ctctcctcaa gcgtattcaa     1680

caaggggctg aaggatgccc agaaggtacc ccattgtatg ggatctgatc tggggcctcg     1740

gtgcacatgc tttacatgtg tttagtcgag gttaaaaaaa cgtctaggcc ccccgaacca     1800

cggggacgtg gttttccttt gaaaaacacg atgataatat ggccacaacc tgaatggcct     1860

taccagtgac cgccttgctc ctgccgctgg ccttgctgct ccacgccgcc aggccggact     1920

acaaagacga tgacgacaag gacatccaga tgacacagac tacatcctcc ctgtctgcct     1980

ctctgggaga cagagtcacc atcagttgca gggcaagtca ggacattagt aaatatttaa     2040

attggtatca gcagaaacca gatggaactg ttaaactcct gatctaccat acatcaagat     2100

tacactcagg agtcccatca aggttcagtg gcagtgggtc tggaacagat tattctctca     2160

ccattagcaa cctggagcaa gaagatattg ccacttactt ttgccaacag ggtaatacgc     2220

ttccgtacac gttcggaggg gggaccaagc tggagatcac aggtggcggt ggctcgggcg     2280

gtggtgggtc gggtggcggc ggatctgagg tgaaactgca ggagtcagga cctggcctgg     2340

tggcgccctc acagagcctg tccgtcacat gcactgtctc aggggtctca ttacccgact     2400

atggtgtaag ctggattcgc cagcctccac gaaagggtct ggagtggctg ggagtaatat     2460

ggggtagtga aaccacatac tataattcag ctctcaaatc cagactgacc atcatcaagg     2520

acaactccaa gagccaagtt ttcttaaaaa tgaacagtct gcaaactgat gacacagcca     2580

tttactactg tgccaaacat tattactacg gtggtagcta tgctatggac tactggggcc     2640

aaggaacctc agtcaccgtc tcctcaacca ctaccccagc accgaggcca cccaccccgg     2700

ctcctaccat cgcctcccag cctctgtccc tgcgtccgga ggcatgtaga cccgcagctg     2760

gtggggccgt gcatacccgg ggtcttgact tcgcctgcga tatctacatt tgggcccctc     2820

tggctggtac ttgcggggtc ctgctgcttt cactcgtgat cactctttac tgtaagcgcg     2880

gtcggaagaa gctgctgtac atctttaagc aacccttcat gaggcctgtg cagactactc     2940

aagaggagga cggctgttca tgccggttcc cagaggagga ggaaggcggc tgcgaactgc     3000

gcgtgaaatt cagccgcagc gcagatgctc cagcctacaa gcaggggcag aaccagctct     3060

acaacgaact caatcttggt cggagagagg agtacgacgt gctggacaag cggagaggac     3120

gggacccaga aatgggcggg aagccgcgca gaaagaatcc ccaagagggc ctgtacaacg     3180

agctccaaaa ggataagatg gcagaagcct atagcgagat tggtatgaaa ggggaacgca     3240

gaagaggcaa aggccacgac ggactgtacc agggactcag caccgccacc aaggacacct     3300

atgacgctct tcacatgcag gccctgccgc ctcggtga                             3338


<210>  32
<211>  3047
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  artificial construct

<400>  32
atggcactgc cagtgaccgc cctgctgctg cctctggccc tgctgctgca cgcagccaga       60

cccgagcaga agctgatctc cgaggaggac ctgcaggtgc agctgcagca gtctggacct      120

gagctggtga agccaggagc ctccgtgaag atgtcttgca aggccagcgg ctacaccttc      180

acatcttatc acatccagtg ggtgaagcag cggcccggac agggcctgga gtggatcgga      240

tggatctacc caggcgacgg ctccacacag tataacgaga agttcaaggg caagaccaca      300

ctgaccgccg ataagagcag cagcaccgcc tacatgctgc tgagcagcct gaccagcgag      360

gacagcgcca tctacttttg cgccagggag ggcacatact atgctatgga ctattggggc      420

cagggcacca gcgtgacagt gtctagcgga ggaggaggct ccggaggagg aggctctggc      480

ggcggcggca gcgacgtgct gatgacccag acaccactga gcctgcccgt gagcctgggc      540

gatcaggtga gcatctcctg tagatcctct cagagcatcg tgcactccaa cggcaatacc      600

tacctggagt ggtatctgca gaagccaggc cagtccccca agctgctgat ctataaggtg      660

tctaatcggt tcagcggcgt gcctgacaga ttttctggca gcggctccgg caccgacttc      720

accctgaaga tcagccgggt ggaggcagag gatctgggcg tgtactattg tttccagggc      780

tcccacgtgc cacgcacctt tggcggcggc acaaagctgg agatcaagac cgagaggaga      840

gcagaggtgc ccacagcaca cccatctcca agccctaggc cagcaggaca gttccagacc      900

ctggtggtgg gagtggtggg aggcctgctg ggctctctgg tgctgctggt gtgggtgctg      960

gccgtgatct gacccctctc cctccccccc ccctaacgtt actggccgaa gccgcttgga     1020

ataaggccgg tgtgcgtttg tctatatgtt attttccacc atattgccgt cttttggcaa     1080

tgtgagggcc cggaaacctg gccctgtctt cttgacgagc attcctaggg gtctttcccc     1140

tctcgccaaa ggaatgcaag gtctgttgaa tgtcgtgaag gaagcagttc ctctggaagc     1200

ttcttgaaga caaacaacgt ctgtagcgac cctttgcagg cagcggaacc ccccacctgg     1260

cgacaggtgc ctctgcggcc aaaagccacg tgtataagat acacctgcaa aggcggcaca     1320

accccagtgc cacgttgtga gttggatagt tgtggaaaga gtcaaatggc tctcctcaag     1380

cgtattcaac aaggggctga aggatgccca gaaggtaccc cattgtatgg gatctgatct     1440

ggggcctcgg tgcacatgct ttacatgtgt ttagtcgagg ttaaaaaaac gtctaggccc     1500

cccgaaccac ggggacgtgg ttttcctttg aaaaacacga tgataatatg gccacaacct     1560

gaatggcctt accagtgacc gccttgctcc tgccgctggc cttgctgctc cacgccgcca     1620

ggccggacta caaagacgat gacgacaagg acatccagat gacacagact acatcctccc     1680

tgtctgcctc tctgggagac agagtcacca tcagttgcag ggcaagtcag gacattagta     1740

aatatttaaa ttggtatcag cagaaaccag atggaactgt taaactcctg atctaccata     1800

catcaagatt acactcagga gtcccatcaa ggttcagtgg cagtgggtct ggaacagatt     1860

attctctcac cattagcaac ctggagcaag aagatattgc cacttacttt tgccaacagg     1920

gtaatacgct tccgtacacg ttcggagggg ggaccaagct ggagatcaca ggtggcggtg     1980

gctcgggcgg tggtgggtcg ggtggcggcg gatctgaggt gaaactgcag gagtcaggac     2040

ctggcctggt ggcgccctca cagagcctgt ccgtcacatg cactgtctca ggggtctcat     2100

tacccgacta tggtgtaagc tggattcgcc agcctccacg aaagggtctg gagtggctgg     2160

gagtaatatg gggtagtgaa accacatact ataattcagc tctcaaatcc agactgacca     2220

tcatcaagga caactccaag agccaagttt tcttaaaaat gaacagtctg caaactgatg     2280

acacagccat ttactactgt gccaaacatt attactacgg tggtagctat gctatggact     2340

actggggcca aggaacctca gtcaccgtct cctcaaccac taccccagca ccgaggccac     2400

ccaccccggc tcctaccatc gcctcccagc ctctgtccct gcgtccggag gcatgtagac     2460

ccgcagctgg tggggccgtg catacccggg gtcttgactt cgcctgcgat atctacattt     2520

gggcccctct ggctggtact tgcggggtcc tgctgctttc actcgtgatc actctttact     2580

gtaagcgcgg tcggaagaag ctgctgtaca tctttaagca acccttcatg aggcctgtgc     2640

agactactca agaggaggac ggctgttcat gccggttccc agaggaggag gaaggcggct     2700

gcgaactgcg cgtgaaattc agccgcagcg cagatgctcc agcctacaag caggggcaga     2760

accagctcta caacgaactc aatcttggtc ggagagagga gtacgacgtg ctggacaagc     2820

ggagaggacg ggacccagaa atgggcggga agccgcgcag aaagaatccc caagagggcc     2880

tgtacaacga gctccaaaag gataagatgg cagaagccta tagcgagatt ggtatgaaag     2940

gggaacgcag aagaggcaaa ggccacgacg gactgtacca gggactcagc accgccacca     3000

aggacaccta tgacgctctt cacatgcagg ccctgccgcc tcggtga                   3047


<210>  33
<211>  2808
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  artificial construct

<400>  33
atggcactgc cagtgaccgc cctgctgctg cctctggccc tgctgctgca cgcagccaga       60

cccgagcaga agctgatctc cgaggaggac ctgcaggtgc agctgcagca gtctggacct      120

gagctggtga agccaggagc ctccgtgaag atgtcttgca aggccagcgg ctacaccttc      180

acatcttatc acatccagtg ggtgaagcag cggcccggac agggcctgga gtggatcgga      240

tggatctacc caggcgacgg ctccacacag tataacgaga agttcaaggg caagaccaca      300

ctgaccgccg ataagagcag cagcaccgcc tacatgctgc tgagcagcct gaccagcgag      360

gacagcgcca tctacttttg cgccagggag ggcacatact atgctatgga ctattggggc      420

cagggcacca gcgtgacagt gtctagcgga ggaggaggct ccggaggagg aggctctggc      480

ggcggcggca gcgacgtgct gatgacccag acaccactga gcctgcccgt gagcctgggc      540

gatcaggtga gcatctcctg tagatcctct cagagcatcg tgcactccaa cggcaatacc      600

tacctggagt ggtatctgca gaagccaggc cagtccccca agctgctgat ctataaggtg      660

tctaatcggt tcagcggcgt gcctgacaga ttttctggca gcggctccgg caccgacttc      720

accctgaaga tcagccgggt ggaggcagag gatctgggcg tgtactattg tttccagggc      780

tcccacgtgc cacgcacctt tggcggcggc acaaagctgg agatcaagac cgagaggaga      840

gcagaggtgc ccacagcaca cccatctcca agccctaggc cagcaggaca gttccagacc      900

ctggtggtgg gagtggtggg aggcctgctg ggctctctgg tgctgctggt gtgggtgctg      960

gccgtgatct gcagcagggc cgcccgcggc accatcggcg ccaggcgcac aggccagcct     1020

ctgaaggagg acccttccgc cgtgccagtg ttctctgtgg actacggcga gctggatttt     1080

cagtggcggg agaaaacccc agagccacct gtgccctgcg tgcctgagca gaccgagtat     1140

gccacaatcg tgtttccatc cggaatgggc acaagctccc ctgcaaggag aggcagcgcc     1200

gacggaccac ggtccgccca gccactgcgg cccgaggatg gccactgttc ttggcccctg     1260

ggttccggcg cgacaaactt tagcttgctg aagcaagctg gtgacgtgga ggagaatccc     1320

ggccctgcct taccagtgac cgccttgctc ctgccgctgg ccttgctgct ccacgccgcc     1380

aggccggact acaaagacga tgacgacaag gacatccaga tgacacagac tacatcctcc     1440

ctgtctgcct ctctgggaga cagagtcacc atcagttgca gggcaagtca ggacattagt     1500

aaatatttaa attggtatca gcagaaacca gatggaactg ttaaactcct gatctaccat     1560

acatcaagat tacactcagg agtcccatca aggttcagtg gcagtgggtc tggaacagat     1620

tattctctca ccattagcaa cctggagcaa gaagatattg ccacttactt ttgccaacag     1680

ggtaatacgc ttccgtacac gttcggaggg gggaccaagc tggagatcac aggtggcggt     1740

ggctcgggcg gtggtgggtc gggtggcggc ggatctgagg tgaaactgca ggagtcagga     1800

cctggcctgg tggcgccctc acagagcctg tccgtcacat gcactgtctc aggggtctca     1860

ttacccgact atggtgtaag ctggattcgc cagcctccac gaaagggtct ggagtggctg     1920

ggagtaatat ggggtagtga aaccacatac tataattcag ctctcaaatc cagactgacc     1980

atcatcaagg acaactccaa gagccaagtt ttcttaaaaa tgaacagtct gcaaactgat     2040

gacacagcca tttactactg tgccaaacat tattactacg gtggtagcta tgctatggac     2100

tactggggcc aaggaacctc agtcaccgtc tcctcaacca ctaccccagc accgaggcca     2160

cccaccccgg ctcctaccat cgcctcccag cctctgtccc tgcgtccgga ggcatgtaga     2220

cccgcagctg gtggggccgt gcatacccgg ggtcttgact tcgcctgcga tatctacatt     2280

tgggcccctc tggctggtac ttgcggggtc ctgctgcttt cactcgtgat cactctttac     2340

tgtaagcgcg gtcggaagaa gctgctgtac atctttaagc aacccttcat gaggcctgtg     2400

cagactactc aagaggagga cggctgttca tgccggttcc cagaggagga ggaaggcggc     2460

tgcgaactgc gcgtgaaatt cagccgcagc gcagatgctc cagcctacaa gcaggggcag     2520

aaccagctct acaacgaact caatcttggt cggagagagg agtacgacgt gctggacaag     2580

cggagaggac gggacccaga aatgggcggg aagccgcgca gaaagaatcc ccaagagggc     2640

ctgtacaacg agctccaaaa ggataagatg gcagaagcct atagcgagat tggtatgaaa     2700

ggggaacgca gaagaggcaa aggccacgac ggactgtacc agggactcag caccgccacc     2760

aaggacacct atgacgctct tcacatgcag gccctgccgc ctcggtga                  2808


<210>  34
<211>  972
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  artificial construct

<400>  34
atggcactgc cagtgaccgc cctgctgctg cctctggccc tgctgctgca cgcagccaga       60

cccgagcaga agctgatctc cgaggaggac ctgcaggtgc agctgcagca gtctggacct      120

gagctggtga agccaggagc ctccgtgaag atgtcttgca aggccagcgg ctacaccttc      180

acatcttatc acatccagtg ggtgaagcag cggcccggac agggcctgga gtggatcgga      240

tggatctacc caggcgacgg ctccacacag tataacgaga agttcaaggg caagaccaca      300

ctgaccgccg ataagagcag cagcaccgcc tacatgctgc tgagcagcct gaccagcgag      360

gacagcgcca tctacttttg cgccagggag ggcacatact atgctatgga ctattggggc      420

cagggcacca gcgtgacagt gtctagcgga ggaggaggct ccggaggagg aggctctggc      480

ggcggcggca gcgacgtgct gatgacccag acaccactga gcctgcccgt gagcctgggc      540

gatcaggtga gcatctcctg tagatcctct cagagcatcg tgcactccaa cggcaatacc      600

tacctggagt ggtatctgca gaagccaggc cagtccccca agctgctgat ctataaggtg      660

tctaatcggt tcagcggcgt gcctgacaga ttttctggca gcggctccgg caccgacttc      720

accctgaaga tcagccgggt ggaggcagag gatctgggcg tgtactattg tttccagggc      780

tcccacgtgc cacgcacctt tggcggcggc acaaagctgg agatcaagac cgagaggaga      840

gcagaggtgc ccacagcaca cccatctcca agccctaggc cagcaggaca gttccagacc      900

ctggtggtgg gagtggtggg aggcctgctg ggctctctgg tgctgctggt gtgggtgctg      960

gccgtgatct ga                                                          972


<210>  35
<211>  1263
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  artificial construct

<400>  35
atggcactgc cagtgaccgc cctgctgctg cctctggccc tgctgctgca cgcagccaga       60

cccgagcaga agctgatctc cgaggaggac ctgcaggtgc agctgcagca gtctggacct      120

gagctggtga agccaggagc ctccgtgaag atgtcttgca aggccagcgg ctacaccttc      180

acatcttatc acatccagtg ggtgaagcag cggcccggac agggcctgga gtggatcgga      240

tggatctacc caggcgacgg ctccacacag tataacgaga agttcaaggg caagaccaca      300

ctgaccgccg ataagagcag cagcaccgcc tacatgctgc tgagcagcct gaccagcgag      360

gacagcgcca tctacttttg cgccagggag ggcacatact atgctatgga ctattggggc      420

cagggcacca gcgtgacagt gtctagcgga ggaggaggct ccggaggagg aggctctggc      480

ggcggcggca gcgacgtgct gatgacccag acaccactga gcctgcccgt gagcctgggc      540

gatcaggtga gcatctcctg tagatcctct cagagcatcg tgcactccaa cggcaatacc      600

tacctggagt ggtatctgca gaagccaggc cagtccccca agctgctgat ctataaggtg      660

tctaatcggt tcagcggcgt gcctgacaga ttttctggca gcggctccgg caccgacttc      720

accctgaaga tcagccgggt ggaggcagag gatctgggcg tgtactattg tttccagggc      780

tcccacgtgc cacgcacctt tggcggcggc acaaagctgg agatcaagac cgagaggaga      840

gcagaggtgc ccacagcaca cccatctcca agccctaggc cagcaggaca gttccagacc      900

ctggtggtgg gagtggtggg aggcctgctg ggctctctgg tgctgctggt gtgggtgctg      960

gccgtgatct gcagcagggc cgcccgcggc accatcggcg ccaggcgcac aggccagcct     1020

ctgaaggagg acccttccgc cgtgccagtg ttctctgtgg actacggcga gctggatttt     1080

cagtggcggg agaaaacccc agagccacct gtgccctgcg tgcctgagca gaccgagtat     1140

gccacaatcg tgtttccatc cggaatgggc acaagctccc ctgcaaggag aggcagcgcc     1200

gacggaccac ggtccgccca gccactgcgg cccgaggatg gccactgttc ttggcccctg     1260

tga                                                                   1263


<210>  36
<211>  1599
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  artificial construct

<400>  36
atggcactgc cagtgaccgc cctgctgctg cctctggccc tgctgctgca cgcagccaga       60

cccgagcaga agctgatctc cgaggaggac ctgcaggtgc agctgcagca gtctggacct      120

gagctggtga agccaggagc ctccgtgaag atgtcttgca aggccagcgg ctacaccttc      180

acatcttatc acatccagtg ggtgaagcag cggcccggac agggcctgga gtggatcgga      240

tggatctacc caggcgacgg ctccacacag tataacgaga agttcaaggg caagaccaca      300

ctgaccgccg ataagagcag cagcaccgcc tacatgctgc tgagcagcct gaccagcgag      360

gacagcgcca tctacttttg cgccagggag ggcacatact atgctatgga ctattggggc      420

cagggcacca gcgtgacagt gtctagcgga ggaggaggct ccggaggagg aggctctggc      480

ggcggcggca gcgacgtgct gatgacccag acaccactga gcctgcccgt gagcctgggc      540

gatcaggtga gcatctcctg tagatcctct cagagcatcg tgcactccaa cggcaatacc      600

tacctggagt ggtatctgca gaagccaggc cagtccccca agctgctgat ctataaggtg      660

tctaatcggt tcagcggcgt gcctgacaga ttttctggca gcggctccgg caccgacttc      720

accctgaaga tcagccgggt ggaggcagag gatctgggcg tgtactattg tttccagggc      780

tcccacgtgc cacgcacctt tggcggcggc acaaagctgg agatcaagac cgagaggaga      840

gcagaggtgc ccacagcaca cccatctcca agccctaggc cagcaggaca gttccagacc      900

ctggtggtgg gagtggtggg aggcctgctg ggctctctgg tgctgctggt gtgggtgctg      960

gccgtgatct gcagcagggc cgcccgcggc accatcggcg ccaggcgcac aggccagcct     1020

ctgaaggagg acccttccgc cgtgccagtg ttctctgtgg actacggcga gctggatttt     1080

cagtggcggg agaaaacccc agagccacct gtgccctgcg tgcctgagca gaccgagtat     1140

gccacaatcg tgtttccatc cggaatgggc acaagctccc ctgcaaggag aggcagcgcc     1200

gacggaccac ggtccgccca gccactgcgg cccgaggatg gccactgttc ttggcccctg     1260

ggtggcggtg gctcaggcgg tggtgggtcg ggtggcggcg gatcttgcag cagggccgcc     1320

cgcggcacca tcggcgccag gcgcacaggc cagcctctga aggaggaccc ttccgccgtg     1380

ccagtgttct ctgtggacta cggcgagctg gattttcagt ggcgggagaa aaccccagag     1440

ccacctgtgc cctgcgtgcc tgagcagacc gagtatgcca caatcgtgtt tccatccgga     1500

atgggcacaa gctcccctgc aaggagaggc agcgccgacg gaccacggtc cgcccagcca     1560

ctgcggcccg aggatggcca ctgttcttgg cccctgtga                            1599


<210>  37
<211>  2016
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  artificial construct

<400>  37
atggccttac cagtgaccgc cttgctcctg ccgctggcct tgctgctcca cgccgccagg       60

ccggactaca aagacgatga cgacaaggac atccagatga cacagactac atcctccctg      120

tctgcctctc tgggagacag agtcaccatc agttgcaggg caagtcagga cattagtaaa      180

tatttaaatt ggtatcagca gaaaccagat ggaactgtta aactcctgat ctaccataca      240

tcaagattac actcaggagt cccatcaagg ttcagtggca gtgggtctgg aacagattat      300

tctctcacca ttagcaacct ggagcaagaa gatattgcca cttacttttg ccaacagggt      360

aatacgcttc cgtacacgtt cggagggggg accaagctgg agatcacagg tggcggtggc      420

tcgggcggtg gtgggtcggg tggcggcgga tctgaggtga aactgcagga gtcaggacct      480

ggcctggtgg cgccctcaca gagcctgtcc gtcacatgca ctgtctcagg ggtctcatta      540

cccgactatg gtgtaagctg gattcgccag cctccacgaa agggtctgga gtggctggga      600

gtaatatggg gtagtgaaac cacatactat aattcagctc tcaaatccag actgaccatc      660

atcaaggaca actccaagag ccaagttttc ttaaaaatga acagtctgca aactgatgac      720

acagccattt actactgtgc caaacattat tactacggtg gtagctatgc tatggactac      780

tggggccaag gaacctcagt caccgtctcc tcaaccacta ccccagcacc gaggccaccc      840

accccggctc ctaccatcgc ctcccagcct ctgtccctgc gtccggaggc atgtagaccc      900

gcagctggtg gggccgtgca tacccggggt cttgacttcg cctgcgatat ctacatttgg      960

gcccctctgg ctggtacttg cggggtcctg ctgctttcac tcgtgatcac tctttactgt     1020

ctcaggctgc tcttggctct caacttattc ccttcaattc aagtaacagg aaacaagatt     1080

ttggtgaagc agtcgcccat gcttgtagcg tacgacaatg cggtcaacct tagctgcaag     1140

tattcctaca atctcttctc aagggagttc cgggcatccc ttcacaaagg actggatagt     1200

gctgtggaag tctgtgttgt atatgggaat tactcccagc agcttcaggt ttactcaaaa     1260

acggggttca actgtgatgg gaaattgggc aatgaatcag tgacattcta cctccagaat     1320

ttgtatgtta accaaacaga tatttacttc tgcaaaattg aagttatgta tcctcctcct     1380

tacctagaca atgagaagag caatggaacc attatccatg tgaaagggaa acacctttgt     1440

ccaagtcccc tatttcccgg accttctaag cccttttggg tgctggtggt ggttggtgga     1500

gtcctggctt gctatagctt gctagtaaca gtggccttta ttattttctg ggtgaggagt     1560

aagaggagca ggctcctgca cagtgactac atgaacatga ctccccgccg ccccgggccc     1620

acccgcaagc attaccagcc ctatgcccca ccacgcgact tcgcagccta tcgctcccgc     1680

gtgaaattca gccgcagcgc agatgctcca gcctacaagc aggggcagaa ccagctctac     1740

aacgaactca atcttggtcg gagagaggag tacgacgtgc tggacaagcg gagaggacgg     1800

gacccagaaa tgggcgggaa gccgcgcaga aagaatcccc aagagggcct gtacaacgag     1860

ctccaaaagg ataagatggc agaagcctat agcgagattg gtatgaaagg ggaacgcaga     1920

agaggcaaag gccacgacgg actgtaccag ggactcagca ccgccaccaa ggacacctat     1980

gacgctcttc acatgcaggc cctgccgcct cggtga                               2016


<210>  38
<211>  1488
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  artificial construct

<400>  38
atggcactgc cagtgaccgc cctgctgctg cctctggccc tgctgctgca cgcagccaga       60

cccgagcaga agctgatctc cgaggaggac ctggacatcc tgctgaccca gtccccagtg      120

atcctgagcg tgtccccagg agagcgggtg agcttcagct gccgggcctc ccagtctatc      180

ggcaccaata tccactggta tcagcagagg acaaacggct cccctcgcct gctgatcaag      240

tatgccagcg agtccatctc tggcatccca tctaggttca gcggctccgg ctctggcacc      300

gacttcaccc tgtctatcaa tagcgtggag tccgaggaca tcgccgatta ctattgccag      360

cagaacaata actggcccac cacatttggc gcaggcacca agctggagct gaagggaggc      420

ggcggctctg gaggaggagg cagcggcgga ggaggctccc aggtgcagct gaagcagtcc      480

ggaccaggcc tggtgcagcc tagccagtcc ctgtctatca cctgtacagt gtctggcttc      540

agcctgacca actacggagt gcactgggtg cggcagtctc caggcaaggg cctggagtgg      600

ctgggcgtga tctggagcgg aggcaataca gactataaca ccccttttac atccagactg      660

tctatcaata aggataacag caagtcccag gtgttcttta agatgaatag cctccagtcc      720

aacgacaccg ccatctacta ttgtgccaga gccctgacat actatgatta cgagttcgcc      780

tattggggcc agggcaccct ggtgacagtg agcgccacca ctaccccagc accgaggcca      840

cccaccccgg ctcctaccat cgcctcccag cctctgtccc tgcgtccgga ggcatgtaga      900

cccgcagctg gtggggccgt gcatacccgg ggtcttgact tcgcctgcga tatctacatt      960

tgggcccctc tggctggtac ttgcggggtc ctgctgcttt cactcgtgat cactctttac     1020

tgtaagcgcg gtcggaagaa gctgctgtac atctttaagc aacccttcat gaggcctgtg     1080

cagactactc aagaggagga cggctgttca tgccggttcc cagaggagga ggaaggcggc     1140

tgcgaactgc gcgtgaaatt cagccgcagc gcagatgctc cagcctacaa gcaggggcag     1200

aaccagctct acaacgaact caatcttggt cggagagagg agtacgacgt gctggacaag     1260

cggagaggac gggacccaga aatgggcggg aagccgcgca gaaagaatcc ccaagagggc     1320

ctgtacaacg agctccaaaa ggataagatg gcagaagcct atagcgagat tggtatgaaa     1380

ggggaacgca gaagaggcaa aggccacgac ggactgtacc agggactcag caccgccacc     1440

aaggacacct atgacgctct tcacatgcag gccctgccgc ctcggtga                  1488


<210>  39
<211>  493
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  EGFR aCAR (based on Cetuximab scFv)

<400>  39

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Asp Ile Leu Leu Thr Gln Ser Pro Val Ile Leu 
            20                  25                  30          


Ser Val Ser Pro Gly Glu Arg Val Ser Phe Ser Cys Arg Ala Ser Gln 
        35                  40                  45              


Ser Ile Gly Thr Asn Ile His Trp Tyr Gln Gln Arg Thr Asn Gly Ser 
    50                  55                  60                  


Pro Arg Leu Leu Ile Lys Tyr Ala Ser Glu Ser Ile Ser Gly Ile Pro 
65                  70                  75                  80  


Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Ser Ile 
                85                  90                  95      


Asn Ser Val Glu Ser Glu Asp Ile Ala Asp Tyr Tyr Cys Gln Gln Asn 
            100                 105                 110         


Asn Asn Trp Pro Thr Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys 
        115                 120                 125             


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln 
    130                 135                 140                 


Val Gln Leu Lys Gln Ser Gly Pro Gly Leu Val Gln Pro Ser Gln Ser 
145                 150                 155                 160 


Leu Ser Ile Thr Cys Thr Val Ser Gly Phe Ser Leu Thr Asn Tyr Gly 
                165                 170                 175     


Val His Trp Val Arg Gln Ser Pro Gly Lys Gly Leu Glu Trp Leu Gly 
            180                 185                 190         


Val Ile Trp Ser Gly Gly Asn Thr Asp Tyr Asn Thr Pro Phe Thr Ser 
        195                 200                 205             


Arg Leu Ser Ile Asn Lys Asp Asn Ser Lys Ser Gln Val Phe Phe Lys 
    210                 215                 220                 


Met Asn Ser Leu Gln Ser Asn Asp Thr Ala Ile Tyr Tyr Cys Ala Arg 
225                 230                 235                 240 


Ala Leu Thr Tyr Tyr Asp Tyr Glu Phe Ala Tyr Trp Gly Gln Gly Thr 
                245                 250                 255     


Leu Val Thr Val Ser Ala Asp Tyr Lys Asp Asp Asp Asp Lys Thr Thr 
            260                 265                 270         


Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln 
        275                 280                 285             


Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala 
    290                 295                 300                 


Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp Ile Tyr Ile Trp Ala 
305                 310                 315                 320 


Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu Ser Leu Val Ile Thr 
                325                 330                 335     


Leu Tyr Cys Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln 
            340                 345                 350         


Pro Phe Met Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser 
        355                 360                 365             


Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu Arg Val Lys 
    370                 375                 380                 


Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly Gln Asn Gln 
385                 390                 395                 400 


Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu 
                405                 410                 415     


Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg Arg 
            420                 425                 430         


Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met 
        435                 440                 445             


Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly 
    450                 455                 460                 


Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp 
465                 470                 475                 480 


Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
                485                 490             


<210>  40
<211>  493
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  EGFR aCAR (based on Panitumumab scFv)

<400>  40

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu 
            20                  25                  30          


Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Gln Ala Ser Gln 
        35                  40                  45              


Asp Ile Ser Asn Tyr Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala 
    50                  55                  60                  


Pro Lys Leu Leu Ile Tyr Asp Ala Ser Asn Leu Glu Thr Gly Val Pro 
65                  70                  75                  80  


Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Phe Thr Ile 
                85                  90                  95      


Ser Ser Leu Gln Pro Glu Asp Ile Ala Thr Tyr Phe Cys Gln His Phe 
            100                 105                 110         


Asp His Leu Pro Leu Ala Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
        115                 120                 125             


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln 
    130                 135                 140                 


Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu Thr 
145                 150                 155                 160 


Leu Ser Leu Thr Cys Thr Val Ser Gly Gly Ser Val Ser Ser Gly Asp 
                165                 170                 175     


Tyr Tyr Trp Thr Trp Ile Arg Gln Ser Pro Gly Lys Gly Leu Glu Trp 
            180                 185                 190         


Ile Gly His Ile Tyr Tyr Ser Gly Asn Thr Asn Tyr Asn Pro Ser Leu 
        195                 200                 205             


Lys Ser Arg Leu Thr Ile Ser Ile Asp Thr Ser Lys Thr Gln Phe Ser 
    210                 215                 220                 


Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Ile Tyr Tyr Cys 
225                 230                 235                 240 


Val Arg Asp Arg Val Thr Gly Ala Phe Asp Ile Trp Gly Gln Gly Thr 
                245                 250                 255     


Met Val Thr Val Ser Ser Asp Tyr Lys Asp Asp Asp Asp Lys Thr Thr 
            260                 265                 270         


Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln 
        275                 280                 285             


Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala 
    290                 295                 300                 


Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp Ile Tyr Ile Trp Ala 
305                 310                 315                 320 


Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu Ser Leu Val Ile Thr 
                325                 330                 335     


Leu Tyr Cys Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln 
            340                 345                 350         


Pro Phe Met Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser 
        355                 360                 365             


Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu Arg Val Lys 
    370                 375                 380                 


Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly Gln Asn Gln 
385                 390                 395                 400 


Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu 
                405                 410                 415     


Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg Arg 
            420                 425                 430         


Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met 
        435                 440                 445             


Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly 
    450                 455                 460                 


Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp 
465                 470                 475                 480 


Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
                485                 490             


<210>  41
<211>  501
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  EGFR aCAR (based on Nimotuzumab scFv)

<400>  41

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu 
            20                  25                  30          


Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ser Ser Gln 
        35                  40                  45              


Asn Ile Val His Ser Asn Gly Asn Thr Tyr Leu Asp Trp Tyr Gln Gln 
    50                  55                  60                  


Thr Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr Lys Val Ser Asn Arg 
65                  70                  75                  80  


Phe Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp 
                85                  90                  95      


Phe Thr Phe Thr Ile Ser Ser Leu Gln Pro Glu Asp Ile Ala Thr Tyr 
            100                 105                 110         


Tyr Cys Phe Gln Tyr Ser His Val Pro Trp Thr Phe Gly Gln Gly Thr 
        115                 120                 125             


Lys Leu Gln Ile Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
    130                 135                 140                 


Gly Gly Ser Gln Val Gln Leu Gln Gln Ser Gly Ala Glu Val Lys Lys 
145                 150                 155                 160 


Pro Gly Ser Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe 
                165                 170                 175     


Thr Asn Tyr Tyr Ile Tyr Trp Val Arg Gln Ala Pro Gly Gln Gly Leu 
            180                 185                 190         


Glu Trp Ile Gly Gly Ile Asn Pro Thr Ser Gly Gly Ser Asn Phe Asn 
        195                 200                 205             


Glu Lys Phe Lys Thr Arg Val Thr Ile Thr Ala Asp Glu Ser Ser Thr 
    210                 215                 220                 


Thr Ala Tyr Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Phe 
225                 230                 235                 240 


Tyr Phe Cys Thr Arg Gln Gly Leu Trp Phe Asp Ser Asp Gly Arg Gly 
                245                 250                 255     


Phe Asp Phe Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser Asp Tyr 
            260                 265                 270         


Lys Asp Asp Asp Asp Lys Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr 
        275                 280                 285             


Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala 
    290                 295                 300                 


Cys Arg Pro Ala Ala Gly Gly Ala Val His Thr Arg Gly Leu Asp Phe 
305                 310                 315                 320 


Ala Cys Asp Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr Cys Gly Val 
                325                 330                 335     


Leu Leu Leu Ser Leu Val Ile Thr Leu Tyr Cys Lys Arg Gly Arg Lys 
            340                 345                 350         


Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met Arg Pro Val Gln Thr 
        355                 360                 365             


Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe Pro Glu Glu Glu Glu 
    370                 375                 380                 


Gly Gly Cys Glu Leu Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro 
385                 390                 395                 400 


Ala Tyr Gln Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly 
                405                 410                 415     


Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro 
            420                 425                 430         


Glu Met Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr 
        435                 440                 445             


Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly 
    450                 455                 460                 


Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln 
465                 470                 475                 480 


Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln 
                485                 490                 495     


Ala Leu Pro Pro Arg 
            500     


<210>  42
<211>  494
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  EGFR aCAR (based on Necitumumab scFv)

<400>  42

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Glu Ile Val Met Thr Gln Ser Pro Ala Thr Leu 
            20                  25                  30          


Ser Leu Ser Pro Gly Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln 
        35                  40                  45              


Ser Val Ser Ser Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala 
    50                  55                  60                  


Pro Arg Leu Leu Ile Tyr Asp Ala Ser Asn Arg Ala Thr Gly Ile Pro 
65                  70                  75                  80  


Ala Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile 
                85                  90                  95      


Ser Ser Leu Glu Pro Glu Asp Phe Ala Val Tyr Tyr Cys His Gln Tyr 
            100                 105                 110         


Gly Ser Thr Pro Leu Thr Phe Gly Gly Gly Thr Lys Ala Glu Ile Lys 
        115                 120                 125             


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln 
    130                 135                 140                 


Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Gln Thr 
145                 150                 155                 160 


Leu Ser Leu Thr Cys Thr Val Ser Gly Gly Ser Ile Ser Ser Gly Asp 
                165                 170                 175     


Tyr Tyr Trp Ser Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp 
            180                 185                 190         


Ile Gly Tyr Ile Tyr Tyr Ser Gly Ser Thr Asp Tyr Asn Pro Ser Leu 
        195                 200                 205             


Lys Ser Arg Val Thr Met Ser Val Asp Thr Ser Lys Asn Gln Phe Ser 
    210                 215                 220                 


Leu Lys Val Asn Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys 
225                 230                 235                 240 


Ala Arg Val Ser Ile Phe Gly Val Gly Thr Phe Asp Tyr Trp Gly Gln 
                245                 250                 255     


Gly Thr Leu Val Thr Val Ser Ser Tyr Lys Asp Asp Asp Asp Lys Thr 
            260                 265                 270         


Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser 
        275                 280                 285             


Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly 
    290                 295                 300                 


Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp Ile Tyr Ile Trp 
305                 310                 315                 320 


Ala Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu Ser Leu Val Ile 
                325                 330                 335     


Thr Leu Tyr Cys Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys 
            340                 345                 350         


Gln Pro Phe Met Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys 
        355                 360                 365             


Ser Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu Arg Val 
    370                 375                 380                 


Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly Gln Asn 
385                 390                 395                 400 


Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val 
                405                 410                 415     


Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg 
            420                 425                 430         


Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys 
        435                 440                 445             


Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg 
    450                 455                 460                 


Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys 
465                 470                 475                 480 


Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
                485                 490                 


<210>  43
<211>  500
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  EGFR aCAR (based on C10 scFv)

<400>  43

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Gln Ser Val Leu Thr Gln Asp Pro Ala Val Ser 
            20                  25                  30          


Val Ala Leu Gly Gln Thr Val Lys Ile Thr Cys Gln Gly Asp Ser Leu 
        35                  40                  45              


Arg Ser Tyr Phe Ala Ser Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro 
    50                  55                  60                  


Thr Leu Val Met Tyr Ala Arg Asn Asp Arg Pro Ala Gly Val Pro Asp 
65                  70                  75                  80  


Arg Phe Ser Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ser Ala Ile 
                85                  90                  95      


Ser Gly Leu Gln Pro Glu Asp Glu Ala Tyr Tyr Cys Ala Ala Trp Asp 
            100                 105                 110         


Asp Ser Leu Asn Gly Tyr Leu Phe Gly Ala Gly Thr Lys Leu Thr Val 
        115                 120                 125             


Leu Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
    130                 135                 140                 


Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
145                 150                 155                 160 


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Ser Ser Tyr 
                165                 170                 175     


Ala Ile Gly Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
            180                 185                 190         


Gly Gly Ile Ile Pro Ile Phe Gly Ile Ala Asn Tyr Ala Gln Lys Phe 
        195                 200                 205             


Gln Gly Arg Val Thr Ile Thr Ala Asp Glu Ser Thr Ser Ser Ala Tyr 
    210                 215                 220                 


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
225                 230                 235                 240 


Ala Arg Glu Glu Gly Pro Tyr Cys Ser Ser Thr Ser Cys Tyr Ala Ala 
                245                 250                 255     


Phe Asp Ile Trp Gly Gln Gly Thr Leu Val Thr Leu Ser Ser Tyr Lys 
            260                 265                 270         


Asp Asp Asp Asp Lys Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro 
        275                 280                 285             


Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys 
    290                 295                 300                 


Arg Pro Ala Ala Gly Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala 
305                 310                 315                 320 


Cys Asp Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr Cys Gly Val Leu 
                325                 330                 335     


Leu Leu Ser Leu Val Ile Thr Leu Tyr Cys Lys Arg Gly Arg Lys Lys 
            340                 345                 350         


Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met Arg Pro Val Gln Thr Thr 
        355                 360                 365             


Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe Pro Glu Glu Glu Glu Gly 
    370                 375                 380                 


Gly Cys Glu Leu Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala 
385                 390                 395                 400 


Tyr Gln Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg 
                405                 410                 415     


Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu 
            420                 425                 430         


Met Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn 
        435                 440                 445             


Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met 
    450                 455                 460                 


Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly 
465                 470                 475                 480 


Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala 
                485                 490                 495     


Leu Pro Pro Arg 
            500 


<210>  44
<211>  493
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HER2 aCAR based on Trastuzumab scFv

<400>  44

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu 
            20                  25                  30          


Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln 
        35                  40                  45              


Asp Val Asn Thr Ala Val Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala 
    50                  55                  60                  


Pro Lys Leu Leu Ile Tyr Ser Ala Ser Phe Leu Tyr Ser Gly Val Pro 
65                  70                  75                  80  


Ser Arg Phe Ser Gly Ser Arg Ser Gly Thr Asp Phe Thr Leu Thr Ile 
                85                  90                  95      


Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln His 
            100                 105                 110         


Tyr Thr Thr Pro Pro Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
        115                 120                 125             


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu 
    130                 135                 140                 


Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser 
145                 150                 155                 160 


Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Asn Ile Lys Asp Thr Tyr 
                165                 170                 175     


Ile His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ala 
            180                 185                 190         


Arg Ile Tyr Pro Thr Asn Gly Tyr Thr Arg Tyr Ala Asp Ser Val Lys 
        195                 200                 205             


Gly Arg Phe Thr Ile Ser Ala Asp Thr Ser Lys Asn Thr Ala Tyr Leu 
    210                 215                 220                 


Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ser 
225                 230                 235                 240 


Arg Trp Gly Gly Asp Gly Phe Tyr Ala Met Asp Tyr Trp Gly Gln Gly 
                245                 250                 255     


Thr Leu Val Thr Val Ser Ser Tyr Lys Asp Asp Asp Asp Lys Thr Thr 
            260                 265                 270         


Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln 
        275                 280                 285             


Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala 
    290                 295                 300                 


Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp Ile Tyr Ile Trp Ala 
305                 310                 315                 320 


Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu Ser Leu Val Ile Thr 
                325                 330                 335     


Leu Tyr Cys Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln 
            340                 345                 350         


Pro Phe Met Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser 
        355                 360                 365             


Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu Arg Val Lys 
    370                 375                 380                 


Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly Gln Asn Gln 
385                 390                 395                 400 


Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu 
                405                 410                 415     


Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg Arg 
            420                 425                 430         


Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met 
        435                 440                 445             


Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly 
    450                 455                 460                 


Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp 
465                 470                 475                 480 


Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
                485                 490             


<210>  45
<211>  492
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HER2 aCAR based on Pertuzumab scFv

<400>  45

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu 
            20                  25                  30          


Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Lys Ala Ser Gln 
        35                  40                  45              


Asp Val Ser Ile Gly Val Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala 
    50                  55                  60                  


Pro Lys Leu Leu Ile Tyr Ser Ala Ser Tyr Arg Tyr Thr Gly Val Pro 
65                  70                  75                  80  


Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile 
                85                  90                  95      


Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr 
            100                 105                 110         


Tyr Ile Tyr Pro Tyr Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
        115                 120                 125             


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu 
    130                 135                 140                 


Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser 
145                 150                 155                 160 


Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Thr Asp Tyr Thr 
                165                 170                 175     


Met Asp Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ala 
            180                 185                 190         


Asp Val Asn Pro Asn Ser Gly Gly Ser Ile Tyr Asn Gln Arg Phe Lys 
        195                 200                 205             


Gly Arg Phe Thr Leu Ser Val Asp Arg Ser Lys Asn Thr Leu Tyr Leu 
    210                 215                 220                 


Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
225                 230                 235                 240 


Arg Asn Leu Gly Pro Ser Phe Tyr Phe Asp Tyr Trp Gly Gln Gly Thr 
                245                 250                 255     


Leu Val Thr Val Ser Ser Tyr Lys Asp Asp Asp Asp Lys Thr Thr Thr 
            260                 265                 270         


Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro 
        275                 280                 285             


Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala Val 
    290                 295                 300                 


His Thr Arg Gly Leu Asp Phe Ala Cys Asp Ile Tyr Ile Trp Ala Pro 
305                 310                 315                 320 


Leu Ala Gly Thr Cys Gly Val Leu Leu Leu Ser Leu Val Ile Thr Leu 
                325                 330                 335     


Tyr Cys Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro 
            340                 345                 350         


Phe Met Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys 
        355                 360                 365             


Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu Arg Val Lys Phe 
    370                 375                 380                 


Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly Gln Asn Gln Leu 
385                 390                 395                 400 


Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp 
                405                 410                 415     


Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg Arg Lys 
            420                 425                 430         


Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala 
        435                 440                 445             


Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys 
    450                 455                 460                 


Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr 
465                 470                 475                 480 


Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
                485                 490         


<210>  46
<211>  497
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized HLA-A2scFv-IgG- VKA17/VH1-3

<400>  46

Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 
1               5                   10                  15      


Gly Ser Thr Gly Asp Val Val Met Thr Gln Ser Pro Leu Ser Leu Pro 
            20                  25                  30          


Val Thr Leu Gly Gln Pro Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser 
        35                  40                  45              


Ile Val His Ser Asn Gly Asn Thr Tyr Leu Glu Trp Phe Gln Gln Arg 
    50                  55                  60                  


Pro Gly Gln Ser Pro Arg Arg Leu Ile Tyr Lys Val Ser Asn Arg Phe 
65                  70                  75                  80  


Ser Gly Val Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe 
                85                  90                  95      


Thr Leu Lys Ile Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr 
            100                 105                 110         


Cys Phe Gln Gly Ser His Val Pro Arg Thr Phe Gly Gln Gly Thr Lys 
        115                 120                 125             


Leu Glu Ile Lys Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
    130                 135                 140                 


Gly Gly Ser Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys 
145                 150                 155                 160 


Pro Gly Ala Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe 
                165                 170                 175     


Thr Ser Tyr His Ile Gln Trp Val Arg Gln Ala Pro Gly Gln Arg Leu 
            180                 185                 190         


Glu Trp Met Gly Trp Ile Tyr Pro Gly Asp Gly Ser Thr Gln Tyr Asn 
        195                 200                 205             


Glu Lys Phe Lys Gly Arg Val Thr Ile Thr Arg Asp Thr Ser Ala Ser 
    210                 215                 220                 


Thr Ala Tyr Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val 
225                 230                 235                 240 


Tyr Tyr Cys Ala Arg Glu Gly Thr Tyr Tyr Ala Met Asp Tyr Trp Gly 
                245                 250                 255     


Gln Gly Thr Leu Val Thr Val Ser Ser Val Glu Pro Lys Ser Ser Asp 
            260                 265                 270         


Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly 
        275                 280                 285             


Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile 
    290                 295                 300                 


Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu 
305                 310                 315                 320 


Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His 
                325                 330                 335     


Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg 
            340                 345                 350         


Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys 
        355                 360                 365             


Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu 
    370                 375                 380                 


Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr 
385                 390                 395                 400 


Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu 
                405                 410                 415     


Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp 
            420                 425                 430         


Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val 
        435                 440                 445             


Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp 
    450                 455                 460                 


Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His 
465                 470                 475                 480 


Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro 
                485                 490                 495     


Gly 
    


<210>  47
<211>  497
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized HLA-A2scFv-IgG -VKA17/VH1-69

<400>  47

Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 
1               5                   10                  15      


Gly Ser Thr Gly Asp Val Val Met Thr Gln Ser Pro Leu Ser Leu Pro 
            20                  25                  30          


Val Thr Leu Gly Gln Pro Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser 
        35                  40                  45              


Ile Val His Ser Asn Gly Asn Thr Tyr Leu Glu Trp Phe Gln Gln Arg 
    50                  55                  60                  


Pro Gly Gln Ser Pro Arg Arg Leu Ile Tyr Lys Val Ser Asn Arg Phe 
65                  70                  75                  80  


Ser Gly Val Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe 
                85                  90                  95      


Thr Leu Lys Ile Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr 
            100                 105                 110         


Cys Phe Gln Gly Ser His Val Pro Arg Thr Phe Gly Gln Gly Thr Lys 
        115                 120                 125             


Leu Glu Ile Lys Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
    130                 135                 140                 


Gly Gly Ser Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys 
145                 150                 155                 160 


Pro Gly Ser Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe 
                165                 170                 175     


Ser Ser Tyr His Ile Gln Trp Val Arg Gln Ala Pro Gly Gln Gly Leu 
            180                 185                 190         


Glu Trp Met Gly Trp Ile Tyr Pro Gly Asp Gly Ser Thr Gln Tyr Asn 
        195                 200                 205             


Glu Lys Phe Lys Gly Arg Val Thr Ile Thr Ala Asp Lys Ser Thr Ser 
    210                 215                 220                 


Thr Ala Tyr Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val 
225                 230                 235                 240 


Tyr Tyr Cys Ala Arg Glu Gly Thr Tyr Tyr Ala Met Asp Tyr Trp Gly 
                245                 250                 255     


Gln Gly Thr Leu Val Thr Val Ser Ser Val Glu Pro Lys Ser Ser Asp 
            260                 265                 270         


Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly 
        275                 280                 285             


Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile 
    290                 295                 300                 


Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu 
305                 310                 315                 320 


Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His 
                325                 330                 335     


Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg 
            340                 345                 350         


Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys 
        355                 360                 365             


Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu 
    370                 375                 380                 


Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr 
385                 390                 395                 400 


Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu 
                405                 410                 415     


Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp 
            420                 425                 430         


Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val 
        435                 440                 445             


Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp 
    450                 455                 460                 


Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His 
465                 470                 475                 480 


Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro 
                485                 490                 495     


Gly 
    


<210>  48
<211>  497
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized HLA-A2scFv-IgG VKA18/VH1-3

<400>  48

Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 
1               5                   10                  15      


Gly Ser Thr Gly Asp Ile Val Met Thr Gln Thr Pro Leu Ser Leu Ser 
            20                  25                  30          


Val Thr Pro Gly Gln Pro Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser 
        35                  40                  45              


Ile Val His Ser Asn Gly Asn Thr Tyr Leu Glu Trp Tyr Leu Gln Lys 
    50                  55                  60                  


Pro Gly Gln Ser Pro Gln Leu Leu Ile Tyr Lys Val Ser Asn Arg Phe 
65                  70                  75                  80  


Ser Gly Val Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe 
                85                  90                  95      


Thr Leu Lys Ile Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr 
            100                 105                 110         


Cys Phe Gln Gly Ser His Val Pro Arg Thr Phe Gly Gly Gly Thr Lys 
        115                 120                 125             


Val Glu Ile Lys Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
    130                 135                 140                 


Gly Gly Ser Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys 
145                 150                 155                 160 


Pro Gly Ala Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe 
                165                 170                 175     


Thr Ser Tyr His Ile Gln Trp Val Arg Gln Ala Pro Gly Gln Arg Leu 
            180                 185                 190         


Glu Trp Met Gly Trp Ile Tyr Pro Gly Asp Gly Ser Thr Gln Tyr Asn 
        195                 200                 205             


Glu Lys Phe Lys Gly Arg Val Thr Ile Thr Arg Asp Thr Ser Ala Ser 
    210                 215                 220                 


Thr Ala Tyr Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val 
225                 230                 235                 240 


Tyr Tyr Cys Ala Arg Glu Gly Thr Tyr Tyr Ala Met Asp Tyr Trp Gly 
                245                 250                 255     


Gln Gly Thr Leu Val Thr Val Ser Ser Val Glu Pro Lys Ser Ser Asp 
            260                 265                 270         


Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly 
        275                 280                 285             


Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile 
    290                 295                 300                 


Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu 
305                 310                 315                 320 


Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His 
                325                 330                 335     


Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg 
            340                 345                 350         


Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys 
        355                 360                 365             


Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu 
    370                 375                 380                 


Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr 
385                 390                 395                 400 


Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu 
                405                 410                 415     


Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp 
            420                 425                 430         


Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val 
        435                 440                 445             


Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp 
    450                 455                 460                 


Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His 
465                 470                 475                 480 


Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro 
                485                 490                 495     


Gly 
    


<210>  49
<211>  497
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized HLA-A2scFv-IgG VKA18/VH1-69

<400>  49

Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 
1               5                   10                  15      


Gly Ser Thr Gly Asp Ile Val Met Thr Gln Thr Pro Leu Ser Leu Ser 
            20                  25                  30          


Val Thr Pro Gly Gln Pro Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser 
        35                  40                  45              


Ile Val His Ser Asn Gly Asn Thr Tyr Leu Glu Trp Tyr Leu Gln Lys 
    50                  55                  60                  


Pro Gly Gln Ser Pro Gln Leu Leu Ile Tyr Lys Val Ser Asn Arg Phe 
65                  70                  75                  80  


Ser Gly Val Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe 
                85                  90                  95      


Thr Leu Lys Ile Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr 
            100                 105                 110         


Cys Phe Gln Gly Ser His Val Pro Arg Thr Phe Gly Gly Gly Thr Lys 
        115                 120                 125             


Val Glu Ile Lys Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
    130                 135                 140                 


Gly Gly Ser Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys 
145                 150                 155                 160 


Pro Gly Ser Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe 
                165                 170                 175     


Ser Ser Tyr His Ile Gln Trp Val Arg Gln Ala Pro Gly Gln Gly Leu 
            180                 185                 190         


Glu Trp Met Gly Trp Ile Tyr Pro Gly Asp Gly Ser Thr Gln Tyr Asn 
        195                 200                 205             


Glu Lys Phe Lys Gly Arg Val Thr Ile Thr Ala Asp Lys Ser Thr Ser 
    210                 215                 220                 


Thr Ala Tyr Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val 
225                 230                 235                 240 


Tyr Tyr Cys Ala Arg Glu Gly Thr Tyr Tyr Ala Met Asp Tyr Trp Gly 
                245                 250                 255     


Gln Gly Thr Leu Val Thr Val Ser Ser Val Glu Pro Lys Ser Ser Asp 
            260                 265                 270         


Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly 
        275                 280                 285             


Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile 
    290                 295                 300                 


Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu 
305                 310                 315                 320 


Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His 
                325                 330                 335     


Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg 
            340                 345                 350         


Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys 
        355                 360                 365             


Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu 
    370                 375                 380                 


Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr 
385                 390                 395                 400 


Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu 
                405                 410                 415     


Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp 
            420                 425                 430         


Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val 
        435                 440                 445             


Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp 
    450                 455                 460                 


Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His 
465                 470                 475                 480 


Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro 
                485                 490                 495     


Gly 
    


