                         SEQUENCE LISTING

<110>  KYOWA KIRIN CO., LTD.
 
<120>  IL-36 ANTIBODIES AND USES THEREOF

<130>  14233-005-228

<140>  
<141>  

<150>  US 62/739,074
<151>  2018-09-28

<160>  177   

<170>  PatentIn version 3.5

<210>  1
<211>  158
<212>  PRT
<213>  Homo sapiens

<220>
<223>  hIL36a(Q12) (full length)

<400>  1

Met Glu Lys Ala Leu Lys Ile Asp Thr Pro Gln Gln Gly Ser Ile Gln 
1               5                   10                  15      


Asp Ile Asn His Arg Val Trp Val Leu Gln Asp Gln Thr Leu Ile Ala 
            20                  25                  30          


Val Pro Arg Lys Asp Arg Met Ser Pro Val Thr Ile Ala Leu Ile Ser 
        35                  40                  45              


Cys Arg His Val Glu Thr Leu Glu Lys Asp Arg Gly Asn Pro Ile Tyr 
    50                  55                  60                  


Leu Gly Leu Asn Gly Leu Asn Leu Cys Leu Met Cys Ala Lys Val Gly 
65                  70                  75                  80  


Asp Gln Pro Thr Leu Gln Leu Lys Glu Lys Asp Ile Met Asp Leu Tyr 
                85                  90                  95      


Asn Gln Pro Glu Pro Val Lys Ser Phe Leu Phe Tyr His Ser Gln Ser 
            100                 105                 110         


Gly Arg Asn Ser Thr Phe Glu Ser Val Ala Phe Pro Gly Trp Phe Ile 
        115                 120                 125             


Ala Val Ser Ser Glu Gly Gly Cys Pro Leu Ile Leu Thr Gln Glu Leu 
    130                 135                 140                 


Gly Lys Ala Asn Thr Thr Asp Phe Gly Leu Thr Met Leu Phe 
145                 150                 155             


<210>  2
<211>  157
<212>  PRT
<213>  Homo sapiens

<220>
<223>  hIL36b (full length)

<400>  2

Met Asn Pro Gln Arg Glu Ala Ala Pro Lys Ser Tyr Ala Ile Arg Asp 
1               5                   10                  15      


Ser Arg Gln Met Val Trp Val Leu Ser Gly Asn Ser Leu Ile Ala Ala 
            20                  25                  30          


Pro Leu Ser Arg Ser Ile Lys Pro Val Thr Leu His Leu Ile Ala Cys 
        35                  40                  45              


Arg Asp Thr Glu Phe Ser Asp Lys Glu Lys Gly Asn Met Val Tyr Leu 
    50                  55                  60                  


Gly Ile Lys Gly Lys Asp Leu Cys Leu Phe Cys Ala Glu Ile Gln Gly 
65                  70                  75                  80  


Lys Pro Thr Leu Gln Leu Lys Glu Lys Asn Ile Met Asp Leu Tyr Val 
                85                  90                  95      


Glu Lys Lys Ala Gln Lys Pro Phe Leu Phe Phe His Asn Lys Glu Gly 
            100                 105                 110         


Ser Thr Ser Val Phe Gln Ser Val Ser Tyr Pro Gly Trp Phe Ile Ala 
        115                 120                 125             


Thr Ser Thr Thr Ser Gly Gln Pro Ile Phe Leu Thr Lys Glu Arg Gly 
    130                 135                 140                 


Ile Thr Asn Asn Thr Asn Phe Tyr Leu Asp Ser Val Glu 
145                 150                 155         


<210>  3
<211>  169
<212>  PRT
<213>  Homo sapiens

<220>
<223>  hIL36g (full length)

<400>  3

Met Arg Gly Thr Pro Gly Asp Ala Asp Gly Gly Gly Arg Ala Val Tyr 
1               5                   10                  15      


Gln Ser Met Cys Lys Pro Ile Thr Gly Thr Ile Asn Asp Leu Asn Gln 
            20                  25                  30          


Gln Val Trp Thr Leu Gln Gly Gln Asn Leu Val Ala Val Pro Arg Ser 
        35                  40                  45              


Asp Ser Val Thr Pro Val Thr Val Ala Val Ile Thr Cys Lys Tyr Pro 
    50                  55                  60                  


Glu Ala Leu Glu Gln Gly Arg Gly Asp Pro Ile Tyr Leu Gly Ile Gln 
65                  70                  75                  80  


Asn Pro Glu Met Cys Leu Tyr Cys Glu Lys Val Gly Glu Gln Pro Thr 
                85                  90                  95      


Leu Gln Leu Lys Glu Gln Lys Ile Met Asp Leu Tyr Gly Gln Pro Glu 
            100                 105                 110         


Pro Val Lys Pro Phe Leu Phe Tyr Arg Ala Lys Thr Gly Arg Thr Ser 
        115                 120                 125             


Thr Leu Glu Ser Val Ala Phe Pro Asp Trp Phe Ile Ala Ser Ser Lys 
    130                 135                 140                 


Arg Asp Gln Pro Ile Ile Leu Thr Ser Glu Leu Gly Lys Ser Tyr Asn 
145                 150                 155                 160 


Thr Ala Phe Glu Leu Asn Ile Asn Asp 
                165                 


<210>  4
<211>  462
<212>  DNA
<213>  Homo sapiens

<220>
<223>  hIL36a(R12) (truncated)

<400>  4
aaaattgaca cacctcagcg ggggagcatt caggatatca atcatcgggt gtgggttctt       60

caggaccaga cgctcatagc agtcccgagg aaggaccgta tgtctccagt cactattgcc      120

ttaatctcat gccgacatgt ggagaccctt gagaaagaca gagggaaccc catctacctg      180

ggcctgaatg gactcaatct ctgcctgatg tgtgctaaag tcggggacca gcccacactg      240

cagctgaagg aaaaggatat aatggatttg tacaaccaac ccgagcctgt gaagtccttt      300

ctcttctacc acagccagag tggcaggaac tccaccttcg agtctgtggc tttccctggc      360

tggttcatcg ctgtcagctc tgaaggaggc tgtcctctca tccttaccca agaactgggg      420

aaagccaaca ctactgactt tgggttaact atgctgtttt aa                         462


<210>  5
<211>  153
<212>  PRT
<213>  Homo sapiens

<220>
<223>  hIL36a(R12) (truncated)

<400>  5

Lys Ile Asp Thr Pro Gln Arg Gly Ser Ile Gln Asp Ile Asn His Arg 
1               5                   10                  15      


Val Trp Val Leu Gln Asp Gln Thr Leu Ile Ala Val Pro Arg Lys Asp 
            20                  25                  30          


Arg Met Ser Pro Val Thr Ile Ala Leu Ile Ser Cys Arg His Val Glu 
        35                  40                  45              


Thr Leu Glu Lys Asp Arg Gly Asn Pro Ile Tyr Leu Gly Leu Asn Gly 
    50                  55                  60                  


Leu Asn Leu Cys Leu Met Cys Ala Lys Val Gly Asp Gln Pro Thr Leu 
65                  70                  75                  80  


Gln Leu Lys Glu Lys Asp Ile Met Asp Leu Tyr Asn Gln Pro Glu Pro 
                85                  90                  95      


Val Lys Ser Phe Leu Phe Tyr His Ser Gln Ser Gly Arg Asn Ser Thr 
            100                 105                 110         


Phe Glu Ser Val Ala Phe Pro Gly Trp Phe Ile Ala Val Ser Ser Glu 
        115                 120                 125             


Gly Gly Cys Pro Leu Ile Leu Thr Gln Glu Leu Gly Lys Ala Asn Thr 
    130                 135                 140                 


Thr Asp Phe Gly Leu Thr Met Leu Phe 
145                 150             


<210>  6
<211>  462
<212>  DNA
<213>  Homo sapiens

<220>
<223>  hIL36a(Q12) (truncated)

<400>  6
aaaattgaca cacctcagca ggggagcatt caggatatca atcatcgggt gtgggttctt       60

caggaccaga cgctcatagc agtcccgagg aaggaccgta tgtctccagt cactattgcc      120

ttaatctcat gccgacatgt ggagaccctt gagaaagaca gagggaaccc catctacctg      180

ggcctgaatg gactcaatct ctgcctgatg tgtgctaaag tcggggacca gcccacactg      240

cagctgaagg aaaaggatat aatggatttg tacaaccaac ccgagcctgt gaagtccttt      300

ctcttctacc acagccagag tggcaggaac tccaccttcg agtctgtggc tttccctggc      360

tggttcatcg ctgtcagctc tgaaggaggc tgtcctctca tccttaccca agaactgggg      420

aaagccaaca ctactgactt tgggttaact atgctgtttt aa                         462


<210>  7
<211>  153
<212>  PRT
<213>  Homo sapiens

<220>
<223>  hIL36a(Q12) (truncated)

<400>  7

Lys Ile Asp Thr Pro Gln Gln Gly Ser Ile Gln Asp Ile Asn His Arg 
1               5                   10                  15      


Val Trp Val Leu Gln Asp Gln Thr Leu Ile Ala Val Pro Arg Lys Asp 
            20                  25                  30          


Arg Met Ser Pro Val Thr Ile Ala Leu Ile Ser Cys Arg His Val Glu 
        35                  40                  45              


Thr Leu Glu Lys Asp Arg Gly Asn Pro Ile Tyr Leu Gly Leu Asn Gly 
    50                  55                  60                  


Leu Asn Leu Cys Leu Met Cys Ala Lys Val Gly Asp Gln Pro Thr Leu 
65                  70                  75                  80  


Gln Leu Lys Glu Lys Asp Ile Met Asp Leu Tyr Asn Gln Pro Glu Pro 
                85                  90                  95      


Val Lys Ser Phe Leu Phe Tyr His Ser Gln Ser Gly Arg Asn Ser Thr 
            100                 105                 110         


Phe Glu Ser Val Ala Phe Pro Gly Trp Phe Ile Ala Val Ser Ser Glu 
        115                 120                 125             


Gly Gly Cys Pro Leu Ile Leu Thr Gln Glu Leu Gly Lys Ala Asn Thr 
    130                 135                 140                 


Thr Asp Phe Gly Leu Thr Met Leu Phe 
145                 150             


<210>  8
<211>  462
<212>  DNA
<213>  Homo sapiens

<220>
<223>  hIL36b (truncated)

<400>  8
cgggaggcag cacccaaatc ctatgctatt cgtgattctc gacagatggt gtgggtcctg       60

agtggaaatt ctttaatagc agctcctctt agccgcagca ttaagcctgt cactcttcat      120

ttaatagcct gtagagacac agaattcagt gacaaggaaa agggtaatat ggtttacctg      180

ggaatcaagg gaaaagatct ctgtctcttc tgtgcagaaa ttcagggcaa gcctactttg      240

cagcttaagg aaaaaaatat catggacctg tatgtggaga agaaagcaca gaagcccttt      300

ctctttttcc acaataaaga aggctccact tctgtctttc agtcagtctc ttaccctggc      360

tggttcatag ccacctccac cacatcagga cagcccatct ttctcaccaa ggagagaggc      420

ataactaata acactaactt ctacttagat tctgtggaat aa                         462


<210>  9
<211>  153
<212>  PRT
<213>  Homo sapiens

<220>
<223>  hIL36b (truncated)

<400>  9

Arg Glu Ala Ala Pro Lys Ser Tyr Ala Ile Arg Asp Ser Arg Gln Met 
1               5                   10                  15      


Val Trp Val Leu Ser Gly Asn Ser Leu Ile Ala Ala Pro Leu Ser Arg 
            20                  25                  30          


Ser Ile Lys Pro Val Thr Leu His Leu Ile Ala Cys Arg Asp Thr Glu 
        35                  40                  45              


Phe Ser Asp Lys Glu Lys Gly Asn Met Val Tyr Leu Gly Ile Lys Gly 
    50                  55                  60                  


Lys Asp Leu Cys Leu Phe Cys Ala Glu Ile Gln Gly Lys Pro Thr Leu 
65                  70                  75                  80  


Gln Leu Lys Glu Lys Asn Ile Met Asp Leu Tyr Val Glu Lys Lys Ala 
                85                  90                  95      


Gln Lys Pro Phe Leu Phe Phe His Asn Lys Glu Gly Ser Thr Ser Val 
            100                 105                 110         


Phe Gln Ser Val Ser Tyr Pro Gly Trp Phe Ile Ala Thr Ser Thr Thr 
        115                 120                 125             


Ser Gly Gln Pro Ile Phe Leu Thr Lys Glu Arg Gly Ile Thr Asn Asn 
    130                 135                 140                 


Thr Asn Phe Tyr Leu Asp Ser Val Glu 
145                 150             


<210>  10
<211>  152
<212>  PRT
<213>  Homo sapiens

<220>
<223>  hIL36g (truncated)

<400>  10

Ser Met Cys Lys Pro Ile Thr Gly Thr Ile Asn Asp Leu Asn Gln Gln 
1               5                   10                  15      


Val Trp Thr Leu Gln Gly Gln Asn Leu Val Ala Val Pro Arg Ser Asp 
            20                  25                  30          


Ser Val Thr Pro Val Thr Val Ala Val Ile Thr Cys Lys Tyr Pro Glu 
        35                  40                  45              


Ala Leu Glu Gln Gly Arg Gly Asp Pro Ile Tyr Leu Gly Ile Gln Asn 
    50                  55                  60                  


Pro Glu Met Cys Leu Tyr Cys Glu Lys Val Gly Glu Gln Pro Thr Leu 
65                  70                  75                  80  


Gln Leu Lys Glu Gln Lys Ile Met Asp Leu Tyr Gly Gln Pro Glu Pro 
                85                  90                  95      


Val Lys Pro Phe Leu Phe Tyr Arg Ala Lys Thr Gly Arg Thr Ser Thr 
            100                 105                 110         


Leu Glu Ser Val Ala Phe Pro Asp Trp Phe Ile Ala Ser Ser Lys Arg 
        115                 120                 125             


Asp Gln Pro Ile Ile Leu Thr Ser Glu Leu Gly Lys Ser Tyr Asn Thr 
    130                 135                 140                 


Ala Phe Glu Leu Asn Ile Asn Asp 
145                 150         


<210>  11
<211>  154
<212>  PRT
<213>  Homo sapiens

<220>
<223>  hIL36Ra (truncated)

<400>  11

Val Leu Ser Gly Ala Leu Cys Phe Arg Met Lys Asp Ser Ala Leu Lys 
1               5                   10                  15      


Val Leu Tyr Leu His Asn Asn Gln Leu Leu Ala Gly Gly Leu His Ala 
            20                  25                  30          


Gly Lys Val Ile Lys Gly Glu Glu Ile Ser Val Val Pro Asn Arg Trp 
        35                  40                  45              


Leu Asp Ala Ser Leu Ser Pro Val Ile Leu Gly Val Gln Gly Gly Ser 
    50                  55                  60                  


Gln Cys Leu Ser Cys Gly Val Gly Gln Glu Pro Thr Leu Thr Leu Glu 
65                  70                  75                  80  


Pro Val Asn Ile Met Glu Leu Tyr Leu Gly Ala Lys Glu Ser Lys Ser 
                85                  90                  95      


Phe Thr Phe Tyr Arg Arg Asp Met Gly Leu Thr Ser Ser Phe Glu Ser 
            100                 105                 110         


Ala Ala Tyr Pro Gly Trp Phe Leu Cys Thr Val Pro Glu Ala Asp Gln 
        115                 120                 125             


Pro Val Arg Leu Thr Gln Leu Pro Glu Asn Gly Gly Trp Asn Ala Pro 
    130                 135                 140                 


Ile Thr Asp Phe Tyr Phe Gln Gln Cys Asp 
145                 150                 


<210>  12
<211>  462
<212>  DNA
<213>  Macaca fascicularis

<220>
<223>  cyIL36a (truncated)

<400>  12
aaaagtgaaa tgcctcagcc ggtgagcatt caggatatca atcatcgggt gtgggttctt       60

caggaccaga tcctcatagc agtcccgagg aaggaccgtg tgtctccagt cactatttcc      120

ttaatctcat gccgacatgt ggagaccctt gagaaagaca gagggaaccc catctacctg      180

ggactgaatg ggctcaatct ctgcttgatg tgtgctaagg ccggggacca gcccacactg      240

cagctgaagg aaaaggatat aatggatttg tacaaccaac ctgagcctgt gaagtccttt      300

ctcttctacc acagccagag tggcaggaac tccaccttcg agtctgtggc cttccctggc      360

tggttcattg ctgtcagctc tgaaggaggc tgtcctctca tccttaccca agaactgggg      420

aaagccaaca ctactgactt tgggttaact atgctgtttt aa                         462


<210>  13
<211>  153
<212>  PRT
<213>  Macaca fascicularis

<220>
<223>  cyIL36a (truncated)

<400>  13

Lys Ser Glu Met Pro Gln Pro Val Ser Ile Gln Asp Ile Asn His Arg 
1               5                   10                  15      


Val Trp Val Leu Gln Asp Gln Ile Leu Ile Ala Val Pro Arg Lys Asp 
            20                  25                  30          


Arg Val Ser Pro Val Thr Ile Ser Leu Ile Ser Cys Arg His Val Glu 
        35                  40                  45              


Thr Leu Glu Lys Asp Arg Gly Asn Pro Ile Tyr Leu Gly Leu Asn Gly 
    50                  55                  60                  


Leu Asn Leu Cys Leu Met Cys Ala Lys Ala Gly Asp Gln Pro Thr Leu 
65                  70                  75                  80  


Gln Leu Lys Glu Lys Asp Ile Met Asp Leu Tyr Asn Gln Pro Glu Pro 
                85                  90                  95      


Val Lys Ser Phe Leu Phe Tyr His Ser Gln Ser Gly Arg Asn Ser Thr 
            100                 105                 110         


Phe Glu Ser Val Ala Phe Pro Gly Trp Phe Ile Ala Val Ser Ser Glu 
        115                 120                 125             


Gly Gly Cys Pro Leu Ile Leu Thr Gln Glu Leu Gly Lys Ala Asn Thr 
    130                 135                 140                 


Thr Asp Phe Gly Leu Thr Met Leu Phe 
145                 150             


<210>  14
<211>  462
<212>  DNA
<213>  Macaca fascicularis

<220>
<223>  cyIL36b (truncated)

<400>  14
tggcaggcag cacccaaatc ctatgctatt cgtgattctc gacagatggt gtgggtcctg       60

agtggaaatt ctttaatagc agctcctctt agcaaccgtg ttaagcctgt cactcttcat      120

ttaataacct gcagagacac agaattcagt gataagaaaa agggtaatct ggtttacctg      180

ggaatcaggg gaaaagatct ctgtctcttc tgtgaagaaa ttcagggcaa acctactttg      240

cagcttaagg agaaaaacat catggacctg tacatggaga agaaagcaca gaagcccttt      300

ctctttttcc acaataaaga aggctccagt tctgtctttc agtcagtctc ttaccctggc      360

tggttcatag ccacctcctc cacatcagga cagcccatct ttctcaccca ggagaggggc      420

ataactaaca acactaactt ctacttagat tctgtggaat aa                         462


<210>  15
<211>  153
<212>  PRT
<213>  Macaca fascicularis

<220>
<223>  cyIL36b (truncated)

<400>  15

Trp Gln Ala Ala Pro Lys Ser Tyr Ala Ile Arg Asp Ser Arg Gln Met 
1               5                   10                  15      


Val Trp Val Leu Ser Gly Asn Ser Leu Ile Ala Ala Pro Leu Ser Asn 
            20                  25                  30          


Arg Val Lys Pro Val Thr Leu His Leu Ile Thr Cys Arg Asp Thr Glu 
        35                  40                  45              


Phe Ser Asp Lys Lys Lys Gly Asn Leu Val Tyr Leu Gly Ile Arg Gly 
    50                  55                  60                  


Lys Asp Leu Cys Leu Phe Cys Glu Glu Ile Gln Gly Lys Pro Thr Leu 
65                  70                  75                  80  


Gln Leu Lys Glu Lys Asn Ile Met Asp Leu Tyr Met Glu Lys Lys Ala 
                85                  90                  95      


Gln Lys Pro Phe Leu Phe Phe His Asn Lys Glu Gly Ser Ser Ser Val 
            100                 105                 110         


Phe Gln Ser Val Ser Tyr Pro Gly Trp Phe Ile Ala Thr Ser Ser Thr 
        115                 120                 125             


Ser Gly Gln Pro Ile Phe Leu Thr Gln Glu Arg Gly Ile Thr Asn Asn 
    130                 135                 140                 


Thr Asn Phe Tyr Leu Asp Ser Val Glu 
145                 150             


<210>  16
<211>  456
<212>  DNA
<213>  Macaca fascicularis

<220>
<223>  cyIL36g (truncated)

<400>  16
tcaatgcgta cacctattac tgggactatt aatgatttga atcagcaagt gtggaccctt       60

cagggtcaga tccttgtggc agttccacga agtgacagtg tgaccccagt cactgtcgct      120

gttatcacat gcaagtatcc agaggctctt gaccaaagca gaggggatcc catttatttg      180

ggaatccgga atccagaaat gtgtttgtgt tgtgaggagg ttggaggaca gcccacgttg      240

cagctaaaag agcagaagat catggatttg tatggccagc ccgagcctgt gaaacccttc      300

cttttctacc gtgtcaagac cggtaggacc tccacccttg agtctgtggc cttcccaaac      360

tggttcattg cctcttccac gagagaccag cccatcatcc tgacttcaga acttgggaag      420

tcatacaaca ctgcctttga attaaatata aaataa                                456


<210>  17
<211>  151
<212>  PRT
<213>  Macaca fascicularis

<220>
<223>  cyIL36g (truncated)

<400>  17

Ser Met Arg Thr Pro Ile Thr Gly Thr Ile Asn Asp Leu Asn Gln Gln 
1               5                   10                  15      


Val Trp Thr Leu Gln Gly Gln Ile Leu Val Ala Val Pro Arg Ser Asp 
            20                  25                  30          


Ser Val Thr Pro Val Thr Val Ala Val Ile Thr Cys Lys Tyr Pro Glu 
        35                  40                  45              


Ala Leu Asp Gln Ser Arg Gly Asp Pro Ile Tyr Leu Gly Ile Arg Asn 
    50                  55                  60                  


Pro Glu Met Cys Leu Cys Cys Glu Glu Val Gly Gly Gln Pro Thr Leu 
65                  70                  75                  80  


Gln Leu Lys Glu Gln Lys Ile Met Asp Leu Tyr Gly Gln Pro Glu Pro 
                85                  90                  95      


Val Lys Pro Phe Leu Phe Tyr Arg Val Lys Thr Gly Arg Thr Ser Thr 
            100                 105                 110         


Leu Glu Ser Val Ala Phe Pro Asn Trp Phe Ile Ala Ser Ser Thr Arg 
        115                 120                 125             


Asp Gln Pro Ile Ile Leu Thr Ser Glu Leu Gly Lys Ser Tyr Asn Thr 
    130                 135                 140                 


Ala Phe Glu Leu Asn Ile Lys 
145                 150     


<210>  18
<211>  321
<212>  DNA
<213>  Synthetic

<220>
<223>  His-SUMO tag

<400>  18
atgcatcatc accaccatca cgggtccctg caggactcag aagtcaatca agaagctaag       60

ccagaggtca agccagaagt caagcctgag actcacatca atttaaaggt gtccgatgga      120

tcttcagaga tcttcttcaa gatcaaaaag accactcctt taagaaggct gatggaagcg      180

ttcgctaaaa gacagggtaa ggaaatggac tccttaacgt tcttgtacga cggtattgaa      240

attcaagctg atcagacccc tgaagatttg gacatggagg ataacgatat tattgaggct      300

caccgcgaac agattggagg t                                                321


<210>  19
<211>  107
<212>  PRT
<213>  Synthetic

<220>
<223>  His-SUMO tag

<400>  19

Met His His His His His His Gly Ser Leu Gln Asp Ser Glu Val Asn 
1               5                   10                  15      


Gln Glu Ala Lys Pro Glu Val Lys Pro Glu Val Lys Pro Glu Thr His 
            20                  25                  30          


Ile Asn Leu Lys Val Ser Asp Gly Ser Ser Glu Ile Phe Phe Lys Ile 
        35                  40                  45              


Lys Lys Thr Thr Pro Leu Arg Arg Leu Met Glu Ala Phe Ala Lys Arg 
    50                  55                  60                  


Gln Gly Lys Glu Met Asp Ser Leu Thr Phe Leu Tyr Asp Gly Ile Glu 
65                  70                  75                  80  


Ile Gln Ala Asp Gln Thr Pro Glu Asp Leu Asp Met Glu Asp Asn Asp 
                85                  90                  95      


Ile Ile Glu Ala His Arg Glu Gln Ile Gly Gly 
            100                 105         


<210>  20
<211>  420
<212>  DNA
<213>  Mouse

<220>
<223>  144D464A-VH with signal peptide

<400>  20
atgaaatgca gctgggttat cttcttcctg atggcagtgg ttacaggggt caattctgag       60

gttcagctgc agcagtctgg ggcagagctt gtgaagccag gggcctcagt caggttgtcc      120

tgcacagctt ctggcttcaa cattaaagac acctatatac actgggtgaa gcagaggcct      180

gaacagggcc tggagtggat tggaaggatt gatcctgcga ttggtactac tagatatgac      240

ccgaagttcc agggcaaggc cactataaca acagacacat cctccgacac agtccacctg      300

cagttcagca gcctgacatc tgaggacact gccgtctatt actgtgctag attgcactac      360

ttcggtaata acttcttctt tgactactgg ggccaaggca ccactctcac agtctcctca      420


<210>  21
<211>  140
<212>  PRT
<213>  Mouse

<220>
<223>  144D464A-VH with signal peptide

<400>  21

Met Lys Cys Ser Trp Val Ile Phe Phe Leu Met Ala Val Val Thr Gly 
1               5                   10                  15      


Val Asn Ser Glu Val Gln Leu Gln Gln Ser Gly Ala Glu Leu Val Lys 
            20                  25                  30          


Pro Gly Ala Ser Val Arg Leu Ser Cys Thr Ala Ser Gly Phe Asn Ile 
        35                  40                  45              


Lys Asp Thr Tyr Ile His Trp Val Lys Gln Arg Pro Glu Gln Gly Leu 
    50                  55                  60                  


Glu Trp Ile Gly Arg Ile Asp Pro Ala Ile Gly Thr Thr Arg Tyr Asp 
65                  70                  75                  80  


Pro Lys Phe Gln Gly Lys Ala Thr Ile Thr Thr Asp Thr Ser Ser Asp 
                85                  90                  95      


Thr Val His Leu Gln Phe Ser Ser Leu Thr Ser Glu Asp Thr Ala Val 
            100                 105                 110         


Tyr Tyr Cys Ala Arg Leu His Tyr Phe Gly Asn Asn Phe Phe Phe Asp 
        115                 120                 125             


Tyr Trp Gly Gln Gly Thr Thr Leu Thr Val Ser Ser 
    130                 135                 140 


<210>  22
<211>  363
<212>  DNA
<213>  Mouse

<220>
<223>  144D464A-VH without signal peptide

<400>  22
gaggttcagc tgcagcagtc tggggcagag cttgtgaagc caggggcctc agtcaggttg       60

tcctgcacag cttctggctt caacattaaa gacacctata tacactgggt gaagcagagg      120

cctgaacagg gcctggagtg gattggaagg attgatcctg cgattggtac tactagatat      180

gacccgaagt tccagggcaa ggccactata acaacagaca catcctccga cacagtccac      240

ctgcagttca gcagcctgac atctgaggac actgccgtct attactgtgc tagattgcac      300

tacttcggta ataacttctt ctttgactac tggggccaag gcaccactct cacagtctcc      360

tca                                                                    363


<210>  23
<211>  121
<212>  PRT
<213>  Mouse

<220>
<223>  144D464A-VH without signal peptide

<400>  23

Glu Val Gln Leu Gln Gln Ser Gly Ala Glu Leu Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Arg Leu Ser Cys Thr Ala Ser Gly Phe Asn Ile Lys Asp Thr 
            20                  25                  30          


Tyr Ile His Trp Val Lys Gln Arg Pro Glu Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Arg Ile Asp Pro Ala Ile Gly Thr Thr Arg Tyr Asp Pro Lys Phe 
    50                  55                  60                  


Gln Gly Lys Ala Thr Ile Thr Thr Asp Thr Ser Ser Asp Thr Val His 
65                  70                  75                  80  


Leu Gln Phe Ser Ser Leu Thr Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Leu His Tyr Phe Gly Asn Asn Phe Phe Phe Asp Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Thr Leu Thr Val Ser Ser 
        115                 120     


<210>  24
<211>  420
<212>  DNA
<213>  Mouse

<220>
<223>  144L249B-VH with signal peptide

<400>  24
atgaaatgca gcggggttat cttcttcctg atggcagtgg ttacaggggt caactcagag       60

gttcagctgc agcagtctgg ggcagagctt gtgaagccag gggcctcagt caagttgtcc      120

tgcacagctt ctggcttcaa cattaaagac acctatatat actgggtgaa gcagaggcct      180

gaacagggcc tggagtggat tggaaggatt gatcctgcga ttggtactac tagatatgac      240

ccgaagttcc agggcaaggc cactctaaca gcagacacat cctccaacac agccttcctg      300

cagctcagca gcctgacatc tgaggacact gccgtctatt actgtgctag atatgactac      360

tccggtagta gcttctactt tgactactgg ggccgaggca ccactctcac agtctcctca      420


<210>  25
<211>  140
<212>  PRT
<213>  Mouse

<220>
<223>  144L249B-VH with signal peptide

<400>  25

Met Lys Cys Ser Gly Val Ile Phe Phe Leu Met Ala Val Val Thr Gly 
1               5                   10                  15      


Val Asn Ser Glu Val Gln Leu Gln Gln Ser Gly Ala Glu Leu Val Lys 
            20                  25                  30          


Pro Gly Ala Ser Val Lys Leu Ser Cys Thr Ala Ser Gly Phe Asn Ile 
        35                  40                  45              


Lys Asp Thr Tyr Ile Tyr Trp Val Lys Gln Arg Pro Glu Gln Gly Leu 
    50                  55                  60                  


Glu Trp Ile Gly Arg Ile Asp Pro Ala Ile Gly Thr Thr Arg Tyr Asp 
65                  70                  75                  80  


Pro Lys Phe Gln Gly Lys Ala Thr Leu Thr Ala Asp Thr Ser Ser Asn 
                85                  90                  95      


Thr Ala Phe Leu Gln Leu Ser Ser Leu Thr Ser Glu Asp Thr Ala Val 
            100                 105                 110         


Tyr Tyr Cys Ala Arg Tyr Asp Tyr Ser Gly Ser Ser Phe Tyr Phe Asp 
        115                 120                 125             


Tyr Trp Gly Arg Gly Thr Thr Leu Thr Val Ser Ser 
    130                 135                 140 


<210>  26
<211>  363
<212>  DNA
<213>  Mouse

<220>
<223>  144L249B-VH without signal peptide

<400>  26
gaggttcagc tgcagcagtc tggggcagag cttgtgaagc caggggcctc agtcaagttg       60

tcctgcacag cttctggctt caacattaaa gacacctata tatactgggt gaagcagagg      120

cctgaacagg gcctggagtg gattggaagg attgatcctg cgattggtac tactagatat      180

gacccgaagt tccagggcaa ggccactcta acagcagaca catcctccaa cacagccttc      240

ctgcagctca gcagcctgac atctgaggac actgccgtct attactgtgc tagatatgac      300

tactccggta gtagcttcta ctttgactac tggggccgag gcaccactct cacagtctcc      360

tca                                                                    363


<210>  27
<211>  121
<212>  PRT
<213>  Mouse

<220>
<223>  144L249B-VH without signal peptide

<400>  27

Glu Val Gln Leu Gln Gln Ser Gly Ala Glu Leu Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Leu Ser Cys Thr Ala Ser Gly Phe Asn Ile Lys Asp Thr 
            20                  25                  30          


Tyr Ile Tyr Trp Val Lys Gln Arg Pro Glu Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Arg Ile Asp Pro Ala Ile Gly Thr Thr Arg Tyr Asp Pro Lys Phe 
    50                  55                  60                  


Gln Gly Lys Ala Thr Leu Thr Ala Asp Thr Ser Ser Asn Thr Ala Phe 
65                  70                  75                  80  


Leu Gln Leu Ser Ser Leu Thr Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Tyr Asp Tyr Ser Gly Ser Ser Phe Tyr Phe Asp Tyr Trp Gly 
            100                 105                 110         


Arg Gly Thr Thr Leu Thr Val Ser Ser 
        115                 120     


<210>  28
<211>  420
<212>  DNA
<213>  Mouse

<220>
<223>  144L124B, 144L180A-VH with signal peptide

<400>  28
atgaaatgca gctgggttat cttcttcctg atggcagtgg ttacaggggt caattcagag       60

gttcagctgc agcagtctgg ggcagagctt gtgaagccag gggcctcagt caagttgtcc      120

tgcacagctt ctggcttcaa cattaaagac acctatattt actgggtgaa gcagaggcct      180

gaacagggcc tggaatggat tggaaggatt gatcctgcga atggttatac tagatatgac      240

ccgaagttcc agggcaaggc cactatgaca gcagacacat cctccaacac agcctacctg      300

cagctcagca gcctgacatc tgaggacact gccgtctatt actgtgctag atatgaatac      360

tacgatagta gcttctactt tgactactgg ggccaaggca ccactctcac agtctcctca      420


<210>  29
<211>  140
<212>  PRT
<213>  Mouse

<220>
<223>  144L124B, 144L180A-VH with signal peptide

<400>  29

Met Lys Cys Ser Trp Val Ile Phe Phe Leu Met Ala Val Val Thr Gly 
1               5                   10                  15      


Val Asn Ser Glu Val Gln Leu Gln Gln Ser Gly Ala Glu Leu Val Lys 
            20                  25                  30          


Pro Gly Ala Ser Val Lys Leu Ser Cys Thr Ala Ser Gly Phe Asn Ile 
        35                  40                  45              


Lys Asp Thr Tyr Ile Tyr Trp Val Lys Gln Arg Pro Glu Gln Gly Leu 
    50                  55                  60                  


Glu Trp Ile Gly Arg Ile Asp Pro Ala Asn Gly Tyr Thr Arg Tyr Asp 
65                  70                  75                  80  


Pro Lys Phe Gln Gly Lys Ala Thr Met Thr Ala Asp Thr Ser Ser Asn 
                85                  90                  95      


Thr Ala Tyr Leu Gln Leu Ser Ser Leu Thr Ser Glu Asp Thr Ala Val 
            100                 105                 110         


Tyr Tyr Cys Ala Arg Tyr Glu Tyr Tyr Asp Ser Ser Phe Tyr Phe Asp 
        115                 120                 125             


Tyr Trp Gly Gln Gly Thr Thr Leu Thr Val Ser Ser 
    130                 135                 140 


<210>  30
<211>  363
<212>  DNA
<213>  Mouse

<220>
<223>  144L124B, 144L180A-VH without signal peptide

<400>  30
gaggttcagc tgcagcagtc tggggcagag cttgtgaagc caggggcctc agtcaagttg       60

tcctgcacag cttctggctt caacattaaa gacacctata tttactgggt gaagcagagg      120

cctgaacagg gcctggaatg gattggaagg attgatcctg cgaatggtta tactagatat      180

gacccgaagt tccagggcaa ggccactatg acagcagaca catcctccaa cacagcctac      240

ctgcagctca gcagcctgac atctgaggac actgccgtct attactgtgc tagatatgaa      300

tactacgata gtagcttcta ctttgactac tggggccaag gcaccactct cacagtctcc      360

tca                                                                    363


<210>  31
<211>  121
<212>  PRT
<213>  Mouse

<220>
<223>  144L124B, 144L180A-VH without signal peptide

<400>  31

Glu Val Gln Leu Gln Gln Ser Gly Ala Glu Leu Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Leu Ser Cys Thr Ala Ser Gly Phe Asn Ile Lys Asp Thr 
            20                  25                  30          


Tyr Ile Tyr Trp Val Lys Gln Arg Pro Glu Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Arg Ile Asp Pro Ala Asn Gly Tyr Thr Arg Tyr Asp Pro Lys Phe 
    50                  55                  60                  


Gln Gly Lys Ala Thr Met Thr Ala Asp Thr Ser Ser Asn Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Leu Ser Ser Leu Thr Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Tyr Glu Tyr Tyr Asp Ser Ser Phe Tyr Phe Asp Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Thr Leu Thr Val Ser Ser 
        115                 120     


<210>  32
<211>  420
<212>  DNA
<213>  Mouse

<220>
<223>  144L133B-VH with signal peptide

<400>  32
atgaagtgca gcggggttat cttcttcctg atggcagtgg ttacaggggt caactcagag       60

gttcagctgc agcagtctgg ggcagagctt gtgaagccag gggcctcagt caagttgtcc      120

tgcacagctt ctggcttcaa cattaaagac acctatatgt actgggtgaa gcagaggcct      180

gaacagggcc tggagtggat tggaaggatt gatcctgcga ttggtactac tagatatgac      240

ccgaagttcc agggcaaggc cactctaaca gcagacacat cctccaacac agccttcctg      300

cagctcagca gcctgacatc tgaggacact gccgtctatt actgtgctag atatgactac      360

tccggtagta gcttctactt tgactactgg ggccgaggca ccactctcac agtctcctca      420


<210>  33
<211>  140
<212>  PRT
<213>  Mouse

<220>
<223>  144L133B-VH with signal peptide

<400>  33

Met Lys Cys Ser Gly Val Ile Phe Phe Leu Met Ala Val Val Thr Gly 
1               5                   10                  15      


Val Asn Ser Glu Val Gln Leu Gln Gln Ser Gly Ala Glu Leu Val Lys 
            20                  25                  30          


Pro Gly Ala Ser Val Lys Leu Ser Cys Thr Ala Ser Gly Phe Asn Ile 
        35                  40                  45              


Lys Asp Thr Tyr Met Tyr Trp Val Lys Gln Arg Pro Glu Gln Gly Leu 
    50                  55                  60                  


Glu Trp Ile Gly Arg Ile Asp Pro Ala Ile Gly Thr Thr Arg Tyr Asp 
65                  70                  75                  80  


Pro Lys Phe Gln Gly Lys Ala Thr Leu Thr Ala Asp Thr Ser Ser Asn 
                85                  90                  95      


Thr Ala Phe Leu Gln Leu Ser Ser Leu Thr Ser Glu Asp Thr Ala Val 
            100                 105                 110         


Tyr Tyr Cys Ala Arg Tyr Asp Tyr Ser Gly Ser Ser Phe Tyr Phe Asp 
        115                 120                 125             


Tyr Trp Gly Arg Gly Thr Thr Leu Thr Val Ser Ser 
    130                 135                 140 


<210>  34
<211>  363
<212>  DNA
<213>  Mouse

<220>
<223>  144L133B-VH without signal peptide

<400>  34
gaggttcagc tgcagcagtc tggggcagag cttgtgaagc caggggcctc agtcaagttg       60

tcctgcacag cttctggctt caacattaaa gacacctata tgtactgggt gaagcagagg      120

cctgaacagg gcctggagtg gattggaagg attgatcctg cgattggtac tactagatat      180

gacccgaagt tccagggcaa ggccactcta acagcagaca catcctccaa cacagccttc      240

ctgcagctca gcagcctgac atctgaggac actgccgtct attactgtgc tagatatgac      300

tactccggta gtagcttcta ctttgactac tggggccgag gcaccactct cacagtctcc      360

tca                                                                    363


<210>  35
<211>  121
<212>  PRT
<213>  Mouse

<220>
<223>  144L133B-VH without signal peptide

<400>  35

Glu Val Gln Leu Gln Gln Ser Gly Ala Glu Leu Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Leu Ser Cys Thr Ala Ser Gly Phe Asn Ile Lys Asp Thr 
            20                  25                  30          


Tyr Met Tyr Trp Val Lys Gln Arg Pro Glu Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Arg Ile Asp Pro Ala Ile Gly Thr Thr Arg Tyr Asp Pro Lys Phe 
    50                  55                  60                  


Gln Gly Lys Ala Thr Leu Thr Ala Asp Thr Ser Ser Asn Thr Ala Phe 
65                  70                  75                  80  


Leu Gln Leu Ser Ser Leu Thr Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Tyr Asp Tyr Ser Gly Ser Ser Phe Tyr Phe Asp Tyr Trp Gly 
            100                 105                 110         


Arg Gly Thr Thr Leu Thr Val Ser Ser 
        115                 120     


<210>  36
<211>  420
<212>  DNA
<213>  Mouse

<220>
<223>  144L472A-VH with signal peptide

<400>  36
atgaaatgca gctgggttat cttcttcctg atggcagtgg ttacaggggt caattcagag       60

gttcagctgc agcagtctgg ggcagagctt gtgaagccag gggcctcagt caagttgtcc      120

tgcacagttt ctggcttcaa cattaaagac acctatatgt actgggtgaa gcagaggcct      180

gaacagggcc tggagtggat tggaaggatt gatcctgcga atggttatgc taaatatgac      240

ccgaagttcc agggcaaggc cactttaaca gcagacacat cttccaatac agcctacctg      300

cagctcagca gcctgacatc tgaggacact gccgtctatt tctgtgctag atttcattgg      360

tacgacagtg ccttctactt tgacttctgg ggccaaggca ccactctcac agtctcctca      420


<210>  37
<211>  140
<212>  PRT
<213>  Mouse

<220>
<223>  144L472A-VH with signal peptide

<400>  37

Met Lys Cys Ser Trp Val Ile Phe Phe Leu Met Ala Val Val Thr Gly 
1               5                   10                  15      


Val Asn Ser Glu Val Gln Leu Gln Gln Ser Gly Ala Glu Leu Val Lys 
            20                  25                  30          


Pro Gly Ala Ser Val Lys Leu Ser Cys Thr Val Ser Gly Phe Asn Ile 
        35                  40                  45              


Lys Asp Thr Tyr Met Tyr Trp Val Lys Gln Arg Pro Glu Gln Gly Leu 
    50                  55                  60                  


Glu Trp Ile Gly Arg Ile Asp Pro Ala Asn Gly Tyr Ala Lys Tyr Asp 
65                  70                  75                  80  


Pro Lys Phe Gln Gly Lys Ala Thr Leu Thr Ala Asp Thr Ser Ser Asn 
                85                  90                  95      


Thr Ala Tyr Leu Gln Leu Ser Ser Leu Thr Ser Glu Asp Thr Ala Val 
            100                 105                 110         


Tyr Phe Cys Ala Arg Phe His Trp Tyr Asp Ser Ala Phe Tyr Phe Asp 
        115                 120                 125             


Phe Trp Gly Gln Gly Thr Thr Leu Thr Val Ser Ser 
    130                 135                 140 


<210>  38
<211>  363
<212>  DNA
<213>  Mouse

<220>
<223>  144L472A-VH without signal peptide

<400>  38
gaggttcagc tgcagcagtc tggggcagag cttgtgaagc caggggcctc agtcaagttg       60

tcctgcacag tttctggctt caacattaaa gacacctata tgtactgggt gaagcagagg      120

cctgaacagg gcctggagtg gattggaagg attgatcctg cgaatggtta tgctaaatat      180

gacccgaagt tccagggcaa ggccacttta acagcagaca catcttccaa tacagcctac      240

ctgcagctca gcagcctgac atctgaggac actgccgtct atttctgtgc tagatttcat      300

tggtacgaca gtgccttcta ctttgacttc tggggccaag gcaccactct cacagtctcc      360

tca                                                                    363


<210>  39
<211>  121
<212>  PRT
<213>  Mouse

<220>
<223>  144L472A-VH without signal peptide

<400>  39

Glu Val Gln Leu Gln Gln Ser Gly Ala Glu Leu Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Leu Ser Cys Thr Val Ser Gly Phe Asn Ile Lys Asp Thr 
            20                  25                  30          


Tyr Met Tyr Trp Val Lys Gln Arg Pro Glu Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Arg Ile Asp Pro Ala Asn Gly Tyr Ala Lys Tyr Asp Pro Lys Phe 
    50                  55                  60                  


Gln Gly Lys Ala Thr Leu Thr Ala Asp Thr Ser Ser Asn Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Leu Ser Ser Leu Thr Ser Glu Asp Thr Ala Val Tyr Phe Cys 
                85                  90                  95      


Ala Arg Phe His Trp Tyr Asp Ser Ala Phe Tyr Phe Asp Phe Trp Gly 
            100                 105                 110         


Gln Gly Thr Thr Leu Thr Val Ser Ser 
        115                 120     


<210>  40
<211>  420
<212>  DNA
<213>  Mouse

<220>
<223>  144D666C-VH with signal peptide

<400>  40
atgaaatgca gctgggttat cttcttcctg atggcagtgg ttacaggggt caattcagag       60

gttcagctgc agcagtctgg ggcagagctt gtgaagccag gggcctcagt caagttgacc      120

tgcacagctt ctggcttcaa cattaaagac acctatatat actgggtgaa acagaggcct      180

gcacagggcc tggagtggat tggaaggatt gatcctgcga atgcttatac taaatttgac      240

ccgaagttcc agggcaaggc cactttaaca gcagacacat cctccaacac agcctacctg      300

cagctcagca gcctgacatc tgaggacact gccgtctatt actgtactag atttcattgg      360

tacggtagta gcttcttctt tgactactgg ggccaaggca ccactctcac agtctcctca      420


<210>  41
<211>  140
<212>  PRT
<213>  Mouse

<220>
<223>  144D666C-VH with signal peptide

<400>  41

Met Lys Cys Ser Trp Val Ile Phe Phe Leu Met Ala Val Val Thr Gly 
1               5                   10                  15      


Val Asn Ser Glu Val Gln Leu Gln Gln Ser Gly Ala Glu Leu Val Lys 
            20                  25                  30          


Pro Gly Ala Ser Val Lys Leu Thr Cys Thr Ala Ser Gly Phe Asn Ile 
        35                  40                  45              


Lys Asp Thr Tyr Ile Tyr Trp Val Lys Gln Arg Pro Ala Gln Gly Leu 
    50                  55                  60                  


Glu Trp Ile Gly Arg Ile Asp Pro Ala Asn Ala Tyr Thr Lys Phe Asp 
65                  70                  75                  80  


Pro Lys Phe Gln Gly Lys Ala Thr Leu Thr Ala Asp Thr Ser Ser Asn 
                85                  90                  95      


Thr Ala Tyr Leu Gln Leu Ser Ser Leu Thr Ser Glu Asp Thr Ala Val 
            100                 105                 110         


Tyr Tyr Cys Thr Arg Phe His Trp Tyr Gly Ser Ser Phe Phe Phe Asp 
        115                 120                 125             


Tyr Trp Gly Gln Gly Thr Thr Leu Thr Val Ser Ser 
    130                 135                 140 


<210>  42
<211>  363
<212>  DNA
<213>  Mouse

<220>
<223>  144D666C-VH without signal peptide

<400>  42
gaggttcagc tgcagcagtc tggggcagag cttgtgaagc caggggcctc agtcaagttg       60

acctgcacag cttctggctt caacattaaa gacacctata tatactgggt gaaacagagg      120

cctgcacagg gcctggagtg gattggaagg attgatcctg cgaatgctta tactaaattt      180

gacccgaagt tccagggcaa ggccacttta acagcagaca catcctccaa cacagcctac      240

ctgcagctca gcagcctgac atctgaggac actgccgtct attactgtac tagatttcat      300

tggtacggta gtagcttctt ctttgactac tggggccaag gcaccactct cacagtctcc      360

tca                                                                    363


<210>  43
<211>  121
<212>  PRT
<213>  Mouse

<220>
<223>  144D666C-VH without signal peptide

<400>  43

Glu Val Gln Leu Gln Gln Ser Gly Ala Glu Leu Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Leu Thr Cys Thr Ala Ser Gly Phe Asn Ile Lys Asp Thr 
            20                  25                  30          


Tyr Ile Tyr Trp Val Lys Gln Arg Pro Ala Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Arg Ile Asp Pro Ala Asn Ala Tyr Thr Lys Phe Asp Pro Lys Phe 
    50                  55                  60                  


Gln Gly Lys Ala Thr Leu Thr Ala Asp Thr Ser Ser Asn Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Leu Ser Ser Leu Thr Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Thr Arg Phe His Trp Tyr Gly Ser Ser Phe Phe Phe Asp Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Thr Leu Thr Val Ser Ser 
        115                 120     


<210>  44
<211>  420
<212>  DNA
<213>  Mouse

<220>
<223>  144J171G-VH with signal peptide

<400>  44
atgaaatgca gctgggttat cttcttcctg atggcagtgg ttacaggggt ctattctgag       60

gttcagctgc agcagtctgg ggcagagctt gtggagccag gggcctcagt caagttgtcc      120

tgcacagctt ctggcttcaa cattaaagac acctacataa actgggtgaa gcagaggcct      180

gaacagggcc tggagtggat tggaaggatt gatcctgcga atggttatac tagatatgcc      240

ccgaagttcc agggcaaggc cactataaca tcagacacat cctccaacac agcctacctg      300

cagctcagca gcctgacatc tgaggacgct gccgtctatt cctgttctac attaaattac      360

tacggtagta gctttttctt tgacttctgg ggccaaggca ccactctcac agtctcctca      420


<210>  45
<211>  140
<212>  PRT
<213>  Mouse

<220>
<223>  144J171G-VH with signal peptide

<400>  45

Met Lys Cys Ser Trp Val Ile Phe Phe Leu Met Ala Val Val Thr Gly 
1               5                   10                  15      


Val Tyr Ser Glu Val Gln Leu Gln Gln Ser Gly Ala Glu Leu Val Glu 
            20                  25                  30          


Pro Gly Ala Ser Val Lys Leu Ser Cys Thr Ala Ser Gly Phe Asn Ile 
        35                  40                  45              


Lys Asp Thr Tyr Ile Asn Trp Val Lys Gln Arg Pro Glu Gln Gly Leu 
    50                  55                  60                  


Glu Trp Ile Gly Arg Ile Asp Pro Ala Asn Gly Tyr Thr Arg Tyr Ala 
65                  70                  75                  80  


Pro Lys Phe Gln Gly Lys Ala Thr Ile Thr Ser Asp Thr Ser Ser Asn 
                85                  90                  95      


Thr Ala Tyr Leu Gln Leu Ser Ser Leu Thr Ser Glu Asp Ala Ala Val 
            100                 105                 110         


Tyr Ser Cys Ser Thr Leu Asn Tyr Tyr Gly Ser Ser Phe Phe Phe Asp 
        115                 120                 125             


Phe Trp Gly Gln Gly Thr Thr Leu Thr Val Ser Ser 
    130                 135                 140 


<210>  46
<211>  363
<212>  DNA
<213>  Mouse

<220>
<223>  144J171G-VH without signal peptide

<400>  46
gaggttcagc tgcagcagtc tggggcagag cttgtggagc caggggcctc agtcaagttg       60

tcctgcacag cttctggctt caacattaaa gacacctaca taaactgggt gaagcagagg      120

cctgaacagg gcctggagtg gattggaagg attgatcctg cgaatggtta tactagatat      180

gccccgaagt tccagggcaa ggccactata acatcagaca catcctccaa cacagcctac      240

ctgcagctca gcagcctgac atctgaggac gctgccgtct attcctgttc tacattaaat      300

tactacggta gtagcttttt ctttgacttc tggggccaag gcaccactct cacagtctcc      360

tca                                                                    363


<210>  47
<211>  121
<212>  PRT
<213>  Mouse

<220>
<223>  144J171G-VH without signal peptide

<400>  47

Glu Val Gln Leu Gln Gln Ser Gly Ala Glu Leu Val Glu Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Leu Ser Cys Thr Ala Ser Gly Phe Asn Ile Lys Asp Thr 
            20                  25                  30          


Tyr Ile Asn Trp Val Lys Gln Arg Pro Glu Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Arg Ile Asp Pro Ala Asn Gly Tyr Thr Arg Tyr Ala Pro Lys Phe 
    50                  55                  60                  


Gln Gly Lys Ala Thr Ile Thr Ser Asp Thr Ser Ser Asn Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Leu Ser Ser Leu Thr Ser Glu Asp Ala Ala Val Tyr Ser Cys 
                85                  90                  95      


Ser Thr Leu Asn Tyr Tyr Gly Ser Ser Phe Phe Phe Asp Phe Trp Gly 
            100                 105                 110         


Gln Gly Thr Thr Leu Thr Val Ser Ser 
        115                 120     


<210>  48
<211>  384
<212>  DNA
<213>  Mouse

<220>
<223>  144D464A-VL with signal peptide

<400>  48
atggcctgga tttcacttat actctctctc ctggctctca gctcaggggc catttcccag       60

gctgttgtga ctcaggaatc tgcactcacc acatcacctg gtgaagcagt cacactcact      120

tgtcgctcaa gttctggggc tgttacaact agtaactatg ccaactgggt ccaagaaaaa      180

ccagatcatt tattcgctgg tctaataggt ggtaccaacg accgagctcc aggtgttcct      240

gccagattct caggctccct gattggagac aaggctgccc tcaccatcac aggggcacag      300

actgaggatg aggcaatata tttctgtgct ctatggttca gcaaccattg ggtgttcggt      360

ggaggaacca aactgactgt ccta                                             384


<210>  49
<211>  128
<212>  PRT
<213>  Mouse

<220>
<223>  144D464A-VL with signal peptide

<400>  49

Met Ala Trp Ile Ser Leu Ile Leu Ser Leu Leu Ala Leu Ser Ser Gly 
1               5                   10                  15      


Ala Ile Ser Gln Ala Val Val Thr Gln Glu Ser Ala Leu Thr Thr Ser 
            20                  25                  30          


Pro Gly Glu Ala Val Thr Leu Thr Cys Arg Ser Ser Ser Gly Ala Val 
        35                  40                  45              


Thr Thr Ser Asn Tyr Ala Asn Trp Val Gln Glu Lys Pro Asp His Leu 
    50                  55                  60                  


Phe Ala Gly Leu Ile Gly Gly Thr Asn Asp Arg Ala Pro Gly Val Pro 
65                  70                  75                  80  


Ala Arg Phe Ser Gly Ser Leu Ile Gly Asp Lys Ala Ala Leu Thr Ile 
                85                  90                  95      


Thr Gly Ala Gln Thr Glu Asp Glu Ala Ile Tyr Phe Cys Ala Leu Trp 
            100                 105                 110         


Phe Ser Asn His Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
        115                 120                 125             


<210>  50
<211>  327
<212>  DNA
<213>  Mouse

<220>
<223>  144D464A-VL without signal peptide

<400>  50
caggctgttg tgactcagga atctgcactc accacatcac ctggtgaagc agtcacactc       60

acttgtcgct caagttctgg ggctgttaca actagtaact atgccaactg ggtccaagaa      120

aaaccagatc atttattcgc tggtctaata ggtggtacca acgaccgagc tccaggtgtt      180

cctgccagat tctcaggctc cctgattgga gacaaggctg ccctcaccat cacaggggca      240

cagactgagg atgaggcaat atatttctgt gctctatggt tcagcaacca ttgggtgttc      300

ggtggaggaa ccaaactgac tgtccta                                          327


<210>  51
<211>  109
<212>  PRT
<213>  Mouse

<220>
<223>  144D464A-VL without signal peptide

<400>  51

Gln Ala Val Val Thr Gln Glu Ser Ala Leu Thr Thr Ser Pro Gly Glu 
1               5                   10                  15      


Ala Val Thr Leu Thr Cys Arg Ser Ser Ser Gly Ala Val Thr Thr Ser 
            20                  25                  30          


Asn Tyr Ala Asn Trp Val Gln Glu Lys Pro Asp His Leu Phe Ala Gly 
        35                  40                  45              


Leu Ile Gly Gly Thr Asn Asp Arg Ala Pro Gly Val Pro Ala Arg Phe 
    50                  55                  60                  


Ser Gly Ser Leu Ile Gly Asp Lys Ala Ala Leu Thr Ile Thr Gly Ala 
65                  70                  75                  80  


Gln Thr Glu Asp Glu Ala Ile Tyr Phe Cys Ala Leu Trp Phe Ser Asn 
                85                  90                  95      


His Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105                 


<210>  52
<211>  384
<212>  DNA
<213>  Mouse

<220>
<223>  144L249B, 144L124B, 144L180A, 144L133B-VL with signal peptide

<400>  52
atggcctgga tttcacttat actctctctc ctggctctca gctcaggggc catttcccag       60

gctgttgtga ctcaggaatc tgcactcacc acatcacctg gtgaaacagt cacactcact      120

tgtcgctcaa gtactggggc tgttacaact agtaactatg ccaactgggt ccaagaaaaa      180

ccagatcatt tattcactgg tctaataggt ggtaccaaca accgagctcc aggtgttcct      240

gccagattct caggctccct gattggagac aaggctgccc tcaccatcac aggggcacag      300

actgaggatg aggcaatata tttctgtgct ctatggtaca gcaaccattt ggtgttcggt      360

ggaggaacca aactgactgt ccta                                             384


<210>  53
<211>  128
<212>  PRT
<213>  Mouse

<220>
<223>  144L249B, 144L124B, 144L180A, 144L133B-VL with signal peptide

<400>  53

Met Ala Trp Ile Ser Leu Ile Leu Ser Leu Leu Ala Leu Ser Ser Gly 
1               5                   10                  15      


Ala Ile Ser Gln Ala Val Val Thr Gln Glu Ser Ala Leu Thr Thr Ser 
            20                  25                  30          


Pro Gly Glu Thr Val Thr Leu Thr Cys Arg Ser Ser Thr Gly Ala Val 
        35                  40                  45              


Thr Thr Ser Asn Tyr Ala Asn Trp Val Gln Glu Lys Pro Asp His Leu 
    50                  55                  60                  


Phe Thr Gly Leu Ile Gly Gly Thr Asn Asn Arg Ala Pro Gly Val Pro 
65                  70                  75                  80  


Ala Arg Phe Ser Gly Ser Leu Ile Gly Asp Lys Ala Ala Leu Thr Ile 
                85                  90                  95      


Thr Gly Ala Gln Thr Glu Asp Glu Ala Ile Tyr Phe Cys Ala Leu Trp 
            100                 105                 110         


Tyr Ser Asn His Leu Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
        115                 120                 125             


<210>  54
<211>  327
<212>  DNA
<213>  Mouse

<220>
<223>  144L249B, 144L124B, 144L180A, 144L133B-VL without signal peptide

<400>  54
caggctgttg tgactcagga atctgcactc accacatcac ctggtgaaac agtcacactc       60

acttgtcgct caagtactgg ggctgttaca actagtaact atgccaactg ggtccaagaa      120

aaaccagatc atttattcac tggtctaata ggtggtacca acaaccgagc tccaggtgtt      180

cctgccagat tctcaggctc cctgattgga gacaaggctg ccctcaccat cacaggggca      240

cagactgagg atgaggcaat atatttctgt gctctatggt acagcaacca tttggtgttc      300

ggtggaggaa ccaaactgac tgtccta                                          327


<210>  55
<211>  109
<212>  PRT
<213>  Mouse

<220>
<223>  144L249B, 144L124B, 144L180A, 144L133B-VL without signal peptide

<400>  55

Gln Ala Val Val Thr Gln Glu Ser Ala Leu Thr Thr Ser Pro Gly Glu 
1               5                   10                  15      


Thr Val Thr Leu Thr Cys Arg Ser Ser Thr Gly Ala Val Thr Thr Ser 
            20                  25                  30          


Asn Tyr Ala Asn Trp Val Gln Glu Lys Pro Asp His Leu Phe Thr Gly 
        35                  40                  45              


Leu Ile Gly Gly Thr Asn Asn Arg Ala Pro Gly Val Pro Ala Arg Phe 
    50                  55                  60                  


Ser Gly Ser Leu Ile Gly Asp Lys Ala Ala Leu Thr Ile Thr Gly Ala 
65                  70                  75                  80  


Gln Thr Glu Asp Glu Ala Ile Tyr Phe Cys Ala Leu Trp Tyr Ser Asn 
                85                  90                  95      


His Leu Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105                 


<210>  56
<211>  384
<212>  DNA
<213>  Mouse

<220>
<223>  144L472A-VL with signal peptide

<400>  56
atggcctgga tttcacttat actctctctc ctggctctca gctcaggggc catttcccag       60

gctgttgtga ctcaggaatc tgcactcacc acatcacctg gtgaaacagt cacactcact      120

tgtcgctcaa gtagtggggc tgttacaact agtaactatg ccaactgggt ccaagaaaaa      180

ccagatcatt tattcactgg tctaataggt ggtaccaaca accgagctcc aggtgttcct      240

gccagattct caggctccct gattggagac aaggctgccc tcaccatcac aggggcacag      300

actgaggatg aggcaatata tttctgtggt ctatggtaca gcaaccattg ggtgttcggt      360

ggaggaacca aactgactgt ccta                                             384


<210>  57
<211>  128
<212>  PRT
<213>  Mouse

<220>
<223>  144L472A-VL with signal peptide

<400>  57

Met Ala Trp Ile Ser Leu Ile Leu Ser Leu Leu Ala Leu Ser Ser Gly 
1               5                   10                  15      


Ala Ile Ser Gln Ala Val Val Thr Gln Glu Ser Ala Leu Thr Thr Ser 
            20                  25                  30          


Pro Gly Glu Thr Val Thr Leu Thr Cys Arg Ser Ser Ser Gly Ala Val 
        35                  40                  45              


Thr Thr Ser Asn Tyr Ala Asn Trp Val Gln Glu Lys Pro Asp His Leu 
    50                  55                  60                  


Phe Thr Gly Leu Ile Gly Gly Thr Asn Asn Arg Ala Pro Gly Val Pro 
65                  70                  75                  80  


Ala Arg Phe Ser Gly Ser Leu Ile Gly Asp Lys Ala Ala Leu Thr Ile 
                85                  90                  95      


Thr Gly Ala Gln Thr Glu Asp Glu Ala Ile Tyr Phe Cys Gly Leu Trp 
            100                 105                 110         


Tyr Ser Asn His Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
        115                 120                 125             


<210>  58
<211>  327
<212>  DNA
<213>  Mouse

<220>
<223>  144L472A-VL without signal peptide

<400>  58
caggctgttg tgactcagga atctgcactc accacatcac ctggtgaaac agtcacactc       60

acttgtcgct caagtagtgg ggctgttaca actagtaact atgccaactg ggtccaagaa      120

aaaccagatc atttattcac tggtctaata ggtggtacca acaaccgagc tccaggtgtt      180

cctgccagat tctcaggctc cctgattgga gacaaggctg ccctcaccat cacaggggca      240

cagactgagg atgaggcaat atatttctgt ggtctatggt acagcaacca ttgggtgttc      300

ggtggaggaa ccaaactgac tgtccta                                          327


<210>  59
<211>  109
<212>  PRT
<213>  Mouse

<220>
<223>  144L472A-VL without signal peptide

<400>  59

Gln Ala Val Val Thr Gln Glu Ser Ala Leu Thr Thr Ser Pro Gly Glu 
1               5                   10                  15      


Thr Val Thr Leu Thr Cys Arg Ser Ser Ser Gly Ala Val Thr Thr Ser 
            20                  25                  30          


Asn Tyr Ala Asn Trp Val Gln Glu Lys Pro Asp His Leu Phe Thr Gly 
        35                  40                  45              


Leu Ile Gly Gly Thr Asn Asn Arg Ala Pro Gly Val Pro Ala Arg Phe 
    50                  55                  60                  


Ser Gly Ser Leu Ile Gly Asp Lys Ala Ala Leu Thr Ile Thr Gly Ala 
65                  70                  75                  80  


Gln Thr Glu Asp Glu Ala Ile Tyr Phe Cys Gly Leu Trp Tyr Ser Asn 
                85                  90                  95      


His Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105                 


<210>  60
<211>  384
<212>  DNA
<213>  Mouse

<220>
<223>  144D666C-VL with signal peptide

<400>  60
atggcctgga tttcacttat actctctctc ctggctctca gctcaggggc catttcccag       60

gctgttgtga ctcaggaatc tgcactcacc acatcacctg gtgaaacagt cacactcact      120

tgtcgctcaa gtactggggc tgttacaact agtaactatg ccaactgggt ccaagaaaaa      180

ccagatcatt tgttcactgg tctaataggt ggtaccgaca accgacctcc aggtgttcct      240

gccagattct caggctccct gattggagac aaggctgccc tcaccatcac aggggcacag      300

actgaggatg aggcaattta tttctgtgct ctatggtaca gcaacctctg ggtgttcggt      360

ggaggaacca aactgactgt ccta                                             384


<210>  61
<211>  128
<212>  PRT
<213>  Mouse

<220>
<223>  144D666C-VL with signal peptide

<400>  61

Met Ala Trp Ile Ser Leu Ile Leu Ser Leu Leu Ala Leu Ser Ser Gly 
1               5                   10                  15      


Ala Ile Ser Gln Ala Val Val Thr Gln Glu Ser Ala Leu Thr Thr Ser 
            20                  25                  30          


Pro Gly Glu Thr Val Thr Leu Thr Cys Arg Ser Ser Thr Gly Ala Val 
        35                  40                  45              


Thr Thr Ser Asn Tyr Ala Asn Trp Val Gln Glu Lys Pro Asp His Leu 
    50                  55                  60                  


Phe Thr Gly Leu Ile Gly Gly Thr Asp Asn Arg Pro Pro Gly Val Pro 
65                  70                  75                  80  


Ala Arg Phe Ser Gly Ser Leu Ile Gly Asp Lys Ala Ala Leu Thr Ile 
                85                  90                  95      


Thr Gly Ala Gln Thr Glu Asp Glu Ala Ile Tyr Phe Cys Ala Leu Trp 
            100                 105                 110         


Tyr Ser Asn Leu Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
        115                 120                 125             


<210>  62
<211>  327
<212>  DNA
<213>  Mouse

<220>
<223>  144D666C-VL without signal peptide

<400>  62
caggctgttg tgactcagga atctgcactc accacatcac ctggtgaaac agtcacactc       60

acttgtcgct caagtactgg ggctgttaca actagtaact atgccaactg ggtccaagaa      120

aaaccagatc atttgttcac tggtctaata ggtggtaccg acaaccgacc tccaggtgtt      180

cctgccagat tctcaggctc cctgattgga gacaaggctg ccctcaccat cacaggggca      240

cagactgagg atgaggcaat ttatttctgt gctctatggt acagcaacct ctgggtgttc      300

ggtggaggaa ccaaactgac tgtccta                                          327


<210>  63
<211>  109
<212>  PRT
<213>  Mouse

<220>
<223>  144D666C-VL without signal peptide

<400>  63

Gln Ala Val Val Thr Gln Glu Ser Ala Leu Thr Thr Ser Pro Gly Glu 
1               5                   10                  15      


Thr Val Thr Leu Thr Cys Arg Ser Ser Thr Gly Ala Val Thr Thr Ser 
            20                  25                  30          


Asn Tyr Ala Asn Trp Val Gln Glu Lys Pro Asp His Leu Phe Thr Gly 
        35                  40                  45              


Leu Ile Gly Gly Thr Asp Asn Arg Pro Pro Gly Val Pro Ala Arg Phe 
    50                  55                  60                  


Ser Gly Ser Leu Ile Gly Asp Lys Ala Ala Leu Thr Ile Thr Gly Ala 
65                  70                  75                  80  


Gln Thr Glu Asp Glu Ala Ile Tyr Phe Cys Ala Leu Trp Tyr Ser Asn 
                85                  90                  95      


Leu Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105                 


<210>  64
<211>  384
<212>  DNA
<213>  Mouse

<220>
<223>  144J171G-VL with signal peptide

<400>  64
atggcctgga tttcacttat actctctctc ctggctctca gctcaggggc catttcccag       60

gctgttgtga ctcaggaatc tgcactcacc acatcacctg gtgaaacagt cacactcact      120

tgtcgctcaa gtactggggc tgttacaact agtaactatg ccaactgggt ccaagaaaaa      180

ccagatcatt tattcactgg tctaataggt ggtaccaaca accgagctcc aggtgttcct      240

gccagattct caggctccct gattggagac aaggctgccc tcaccatcac aggggcacag      300

actgaggatg aggcaatata tttctgtgct ctatggtaca gcaaccattg ggtgttcggt      360

ggaggaacca aactgactgt ccta                                             384


<210>  65
<211>  128
<212>  PRT
<213>  Mouse

<220>
<223>  144J171G-VL with signal peptide

<400>  65

Met Ala Trp Ile Ser Leu Ile Leu Ser Leu Leu Ala Leu Ser Ser Gly 
1               5                   10                  15      


Ala Ile Ser Gln Ala Val Val Thr Gln Glu Ser Ala Leu Thr Thr Ser 
            20                  25                  30          


Pro Gly Glu Thr Val Thr Leu Thr Cys Arg Ser Ser Thr Gly Ala Val 
        35                  40                  45              


Thr Thr Ser Asn Tyr Ala Asn Trp Val Gln Glu Lys Pro Asp His Leu 
    50                  55                  60                  


Phe Thr Gly Leu Ile Gly Gly Thr Asn Asn Arg Ala Pro Gly Val Pro 
65                  70                  75                  80  


Ala Arg Phe Ser Gly Ser Leu Ile Gly Asp Lys Ala Ala Leu Thr Ile 
                85                  90                  95      


Thr Gly Ala Gln Thr Glu Asp Glu Ala Ile Tyr Phe Cys Ala Leu Trp 
            100                 105                 110         


Tyr Ser Asn His Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
        115                 120                 125             


<210>  66
<211>  327
<212>  DNA
<213>  Mouse

<220>
<223>  144J171G-VL without signal peptide

<400>  66
caggctgttg tgactcagga atctgcactc accacatcac ctggtgaaac agtcacactc       60

acttgtcgct caagtactgg ggctgttaca actagtaact atgccaactg ggtccaagaa      120

aaaccagatc atttattcac tggtctaata ggtggtacca acaaccgagc tccaggtgtt      180

cctgccagat tctcaggctc cctgattgga gacaaggctg ccctcaccat cacaggggca      240

cagactgagg atgaggcaat atatttctgt gctctatggt acagcaacca ttgggtgttc      300

ggtggaggaa ccaaactgac tgtccta                                          327


<210>  67
<211>  109
<212>  PRT
<213>  Mouse

<220>
<223>  144J171G-VL without signal peptide

<400>  67

Gln Ala Val Val Thr Gln Glu Ser Ala Leu Thr Thr Ser Pro Gly Glu 
1               5                   10                  15      


Thr Val Thr Leu Thr Cys Arg Ser Ser Thr Gly Ala Val Thr Thr Ser 
            20                  25                  30          


Asn Tyr Ala Asn Trp Val Gln Glu Lys Pro Asp His Leu Phe Thr Gly 
        35                  40                  45              


Leu Ile Gly Gly Thr Asn Asn Arg Ala Pro Gly Val Pro Ala Arg Phe 
    50                  55                  60                  


Ser Gly Ser Leu Ile Gly Asp Lys Ala Ala Leu Thr Ile Thr Gly Ala 
65                  70                  75                  80  


Gln Thr Glu Asp Glu Ala Ile Tyr Phe Cys Ala Leu Trp Tyr Ser Asn 
                85                  90                  95      


His Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105                 


<210>  68
<211>  5
<212>  PRT
<213>  Mouse

<220>
<223>  144D464A CDRH1

<400>  68

Asp Thr Tyr Ile His 
1               5   


<210>  69
<211>  17
<212>  PRT
<213>  Mouse

<220>
<223>  144D464A,144L249B, 144L133B CDRH2

<400>  69

Arg Ile Asp Pro Ala Ile Gly Thr Thr Arg Tyr Asp Pro Lys Phe Gln 
1               5                   10                  15      


Gly 
    


<210>  70
<211>  12
<212>  PRT
<213>  Mouse

<220>
<223>  144D464A CDRH3

<400>  70

Leu His Tyr Phe Gly Asn Asn Phe Phe Phe Asp Tyr 
1               5                   10          


<210>  71
<211>  5
<212>  PRT
<213>  Mouse

<220>
<223>  144L249B, 144L124B, 144L180A, 144D666C CDRH1

<400>  71

Asp Thr Tyr Ile Tyr 
1               5   


<210>  72
<211>  12
<212>  PRT
<213>  Mouse

<220>
<223>  144L249B, 144L133B CDRH3

<400>  72

Tyr Asp Tyr Ser Gly Ser Ser Phe Tyr Phe Asp Tyr 
1               5                   10          


<210>  73
<211>  17
<212>  PRT
<213>  Mouse

<220>
<223>  144L124B, 144L180A CDRH2

<400>  73

Arg Ile Asp Pro Ala Asn Gly Tyr Thr Arg Tyr Asp Pro Lys Phe Gln 
1               5                   10                  15      


Gly 
    


<210>  74
<211>  12
<212>  PRT
<213>  Mouse

<220>
<223>  144L124B, 144L180A CDRH3

<400>  74

Tyr Glu Tyr Tyr Asp Ser Ser Phe Tyr Phe Asp Tyr 
1               5                   10          


<210>  75
<211>  5
<212>  PRT
<213>  Mouse

<220>
<223>  144L133B, 144L472A CDRH1

<400>  75

Asp Thr Tyr Met Tyr 
1               5   


<210>  76
<211>  17
<212>  PRT
<213>  Mouse

<220>
<223>  144L472A CDRH2

<400>  76

Arg Ile Asp Pro Ala Asn Gly Tyr Ala Lys Tyr Asp Pro Lys Phe Gln 
1               5                   10                  15      


Gly 
    


<210>  77
<211>  12
<212>  PRT
<213>  Mouse

<220>
<223>  144L472A CDRH3

<400>  77

Phe His Trp Tyr Asp Ser Ala Phe Tyr Phe Asp Phe 
1               5                   10          


<210>  78
<211>  17
<212>  PRT
<213>  Mouse

<220>
<223>  144D666C CDRH2

<400>  78

Arg Ile Asp Pro Ala Asn Ala Tyr Thr Lys Phe Asp Pro Lys Phe Gln 
1               5                   10                  15      


Gly 
    


<210>  79
<211>  12
<212>  PRT
<213>  Mouse

<220>
<223>  144D666C CDRH3

<400>  79

Phe His Trp Tyr Gly Ser Ser Phe Phe Phe Asp Tyr 
1               5                   10          


<210>  80
<211>  5
<212>  PRT
<213>  Mouse

<220>
<223>  144J171G CDRH1

<400>  80

Asp Thr Tyr Ile Asn 
1               5   


<210>  81
<211>  17
<212>  PRT
<213>  Mouse

<220>
<223>  144J171G CDRH2

<400>  81

Arg Ile Asp Pro Ala Asn Gly Tyr Thr Arg Tyr Ala Pro Lys Phe Gln 
1               5                   10                  15      


Gly 
    


<210>  82
<211>  12
<212>  PRT
<213>  Mouse

<220>
<223>  144J171G CDRH3

<400>  82

Leu Asn Tyr Tyr Gly Ser Ser Phe Phe Phe Asp Phe 
1               5                   10          


<210>  83
<211>  14
<212>  PRT
<213>  Mouse

<220>
<223>  144D464A, 144L472A CDRL1

<400>  83

Arg Ser Ser Ser Gly Ala Val Thr Thr Ser Asn Tyr Ala Asn 
1               5                   10                  


<210>  84
<211>  7
<212>  PRT
<213>  Mouse

<220>
<223>  144D464A CDRL2

<400>  84

Gly Thr Asn Asp Arg Ala Pro 
1               5           


<210>  85
<211>  9
<212>  PRT
<213>  Mouse

<220>
<223>  144D464A CDRL3

<400>  85

Ala Leu Trp Phe Ser Asn His Trp Val 
1               5                   


<210>  86
<211>  14
<212>  PRT
<213>  Mouse

<220>
<223>  144L249B, 144L124B, 144L180A, 144L133B, 144D666C, 144J171G CDRL1

<400>  86

Arg Ser Ser Thr Gly Ala Val Thr Thr Ser Asn Tyr Ala Asn 
1               5                   10                  


<210>  87
<211>  7
<212>  PRT
<213>  Mouse

<220>
<223>  144L249B, 144L124B, 144L180A, 144L133B, 144L472A, 144J171G CDRL2

<400>  87

Gly Thr Asn Asn Arg Ala Pro 
1               5           


<210>  88
<211>  9
<212>  PRT
<213>  Mouse

<220>
<223>  144L249B, 144L124B, 144L180A, 144L133B CDRL3

<400>  88

Ala Leu Trp Tyr Ser Asn His Leu Val 
1               5                   


<210>  89
<211>  9
<212>  PRT
<213>  Mouse

<220>
<223>  144L472A CDRL3

<400>  89

Gly Leu Trp Tyr Ser Asn His Trp Val 
1               5                   


<210>  90
<211>  7
<212>  PRT
<213>  Mouse

<220>
<223>  144D666C CDRL2

<400>  90

Gly Thr Asp Asn Arg Pro Pro 
1               5           


<210>  91
<211>  9
<212>  PRT
<213>  Mouse

<220>
<223>  144D666C CDRL3

<400>  91

Ala Leu Trp Tyr Ser Asn Leu Trp Val 
1               5                   


<210>  92
<211>  9
<212>  PRT
<213>  Mouse

<220>
<223>  144J171G CDRL3

<400>  92

Ala Leu Trp Tyr Ser Asn His Trp Val 
1               5                   


<210>  93
<211>  993
<212>  DNA
<213>  Homo sapiens

<220>
<223>  IgG1 constant (human)

<400>  93
gctagcacca agggcccatc ggtcttcccc ctggcaccct cctccaagag cacctctggg       60

ggcacagcgg ccctgggctg cctggtcaag gactacttcc ccgaaccggt gacggtgtcg      120

tggaactcag gcgccctgac cagcggcgtg cacaccttcc cggctgtcct acagtcctca      180

ggactctact ccctcagcag cgtggtgacc gtgccctcca gcagcttggg cacccagacc      240

tacatctgca acgtgaatca caagcccagc aacaccaagg tggacaagaa agttgagccc      300

aaatcttgtg acaaaactca cacatgccca ccgtgcccag cacctgaact cctgggggga      360

ccgtcagtct tcctcttccc cccaaaaccc aaggacaccc tcatgatctc ccggacccct      420

gaggtcacat gcgtggtggt ggacgtgagc cacgaagacc ctgaggtcaa gttcaactgg      480

tacgtggacg gcgtggaggt gcataatgcc aagacaaagc cgcgggagga gcagtacaac      540

agcacgtacc gtgtggtcag cgtcctcacc gtcctgcacc aggactggct gaatggcaag      600

gagtacaagt gcaaggtctc caacaaagcc ctcccagccc ccatcgagaa aaccatctcc      660

aaagccaaag ggcagccccg agaaccacag gtgtacaccc tgcccccatc ccgggatgag      720

ctgaccaaga accaggtcag cctgacctgc ctggtcaaag gcttctatcc cagcgacatc      780

gccgtggagt gggagagcaa tgggcagccg gagaacaact acaagaccac gcctcccgtg      840

ctggactccg acggctcctt cttcctctac agcaagctca ccgtggacaa gagcaggtgg      900

cagcagggga acgtcttctc atgctccgtg atgcatgagg ctctgcacaa ccactacacg      960

cagaagagcc tctccctgtc tccgggtaaa tga                                   993


<210>  94
<211>  330
<212>  PRT
<213>  Homo sapiens

<220>
<223>  IgG1 constant (human)

<400>  94

Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys 
1               5                   10                  15      


Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
            20                  25                  30          


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        35                  40                  45              


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  


Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr 
65                  70                  75                  80  


Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys 
                85                  90                  95      


Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys 
            100                 105                 110         


Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro 
        115                 120                 125             


Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys 
    130                 135                 140                 


Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp 
145                 150                 155                 160 


Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu 
                165                 170                 175     


Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu 
            180                 185                 190         


His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn 
        195                 200                 205             


Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly 
    210                 215                 220                 


Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu 
225                 230                 235                 240 


Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr 
                245                 250                 255     


Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn 
            260                 265                 270         


Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe 
        275                 280                 285             


Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn 
    290                 295                 300                 


Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr 
305                 310                 315                 320 


Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
                325                 330 


<210>  95
<211>  321
<212>  DNA
<213>  Homo sapiens

<220>
<223>  IgLamdba constant (human) IGLC2

<400>  95
ggtcagccca aggctgcccc ctcggtcact ctgttcccgc cctcctctga ggagcttcaa       60

gccaacaagg ccacactggt gtgtctcata agtgacttct acccgggagc cgtgacagtg      120

gcctggaagg cagatagcag ccccgtcaag gcgggagtgg agaccaccac accctccaaa      180

caaagcaaca acaagtacgc ggccagcagc tacctgagcc tgacgcctga gcagtggaag      240

tcccacagaa gctacagctg ccaggtcacg catgaaggga gcaccgtgga gaagacagtg      300

gcccctacag aatgttcatg a                                                321


<210>  96
<211>  106
<212>  PRT
<213>  Homo sapiens

<220>
<223>  IgLamdba constant (human) IGLC2

<400>  96

Gly Gln Pro Lys Ala Ala Pro Ser Val Thr Leu Phe Pro Pro Ser Ser 
1               5                   10                  15      


Glu Glu Leu Gln Ala Asn Lys Ala Thr Leu Val Cys Leu Ile Ser Asp 
            20                  25                  30          


Phe Tyr Pro Gly Ala Val Thr Val Ala Trp Lys Ala Asp Ser Ser Pro 
        35                  40                  45              


Val Lys Ala Gly Val Glu Thr Thr Thr Pro Ser Lys Gln Ser Asn Asn 
    50                  55                  60                  


Lys Tyr Ala Ala Ser Ser Tyr Leu Ser Leu Thr Pro Glu Gln Trp Lys 
65                  70                  75                  80  


Ser His Arg Ser Tyr Ser Cys Gln Val Thr His Glu Gly Ser Thr Val 
                85                  90                  95      


Glu Lys Thr Val Ala Pro Thr Glu Cys Ser 
            100                 105     


<210>  97
<211>  36
<212>  DNA
<213>  Synthetic

<220>
<223>  primer_1262

<400>  97
gattacgcca agcttgtcac tggctcaggg aaataa                                 36


<210>  98
<211>  38
<212>  DNA
<213>  Synthetic

<220>
<223>  primer_1267


<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  n is c or t

<220>
<221>  misc_feature
<222>  (24)..(24)
<223>  n is a or g

<220>
<221>  misc_feature
<222>  (34)..(34)
<223>  n is a or g

<400>  98
gattacgcca agcttctcnt cagnggaagg tggnaaca                               38


<210>  99
<211>  474
<212>  DNA
<213>  Homo sapiens

<220>
<223>  hIL-36a(Q12) full length

<400>  99
atggaaaaag cattgaaaat tgacacacct cagcagggga gcattcagga tatcaatcat       60

cgggtgtggg ttcttcagga ccagacgctc atagcagtcc cgaggaagga ccgtatgtct      120

ccagtcacta ttgccttaat ctcatgccga catgtggaga cccttgagaa agacagaggg      180

aaccccatct acctgggcct gaatggactc aatctctgcc tgatgtgtgc taaagtcggg      240

gaccagccca cactgcagct gaaggaaaag gatataatgg atttgtacaa ccaacccgag      300

cctgtgaagt cctttctctt ctaccacagc cagagtggca ggaactccac cttcgagtct      360

gtggctttcc ctggctggtt catcgctgtc agctctgaag gaggctgtcc tctcatcctt      420

acccaagaac tggggaaagc caacactact gactttgggt taactatgct gttt            474


<210>  100
<211>  474
<212>  DNA
<213>  Homo sapiens

<220>
<223>  hIL-36a(R12) full length

<400>  100
atggaaaaag cattgaaaat tgacacacct cagcggggga gcattcagga tatcaatcat       60

cgggtgtggg ttcttcagga ccagacgctc atagcagtcc cgaggaagga ccgtatgtct      120

ccagtcacta ttgccttaat ctcatgccga catgtggaga cccttgagaa agacagaggg      180

aaccccatct acctgggcct gaatggactc aatctctgcc tgatgtgtgc taaagtcggg      240

gaccagccca cactgcagct gaaggaaaag gatataatgg atttgtacaa ccaacccgag      300

cctgtgaagt cctttctctt ctaccacagc cagagtggca ggaactccac cttcgagtct      360

gtggctttcc ctggctggtt catcgctgtc agctctgaag gaggctgtcc tctcatcctt      420

acccaagaac tggggaaagc caacactact gactttgggt taactatgct gttt            474


<210>  101
<211>  158
<212>  PRT
<213>  Homo sapiens

<220>
<223>  hIL-36a(R12) full length

<400>  101

Met Glu Lys Ala Leu Lys Ile Asp Thr Pro Gln Arg Gly Ser Ile Gln 
1               5                   10                  15      


Asp Ile Asn His Arg Val Trp Val Leu Gln Asp Gln Thr Leu Ile Ala 
            20                  25                  30          


Val Pro Arg Lys Asp Arg Met Ser Pro Val Thr Ile Ala Leu Ile Ser 
        35                  40                  45              


Cys Arg His Val Glu Thr Leu Glu Lys Asp Arg Gly Asn Pro Ile Tyr 
    50                  55                  60                  


Leu Gly Leu Asn Gly Leu Asn Leu Cys Leu Met Cys Ala Lys Val Gly 
65                  70                  75                  80  


Asp Gln Pro Thr Leu Gln Leu Lys Glu Lys Asp Ile Met Asp Leu Tyr 
                85                  90                  95      


Asn Gln Pro Glu Pro Val Lys Ser Phe Leu Phe Tyr His Ser Gln Ser 
            100                 105                 110         


Gly Arg Asn Ser Thr Phe Glu Ser Val Ala Phe Pro Gly Trp Phe Ile 
        115                 120                 125             


Ala Val Ser Ser Glu Gly Gly Cys Pro Leu Ile Leu Thr Gln Glu Leu 
    130                 135                 140                 


Gly Lys Ala Asn Thr Thr Asp Phe Gly Leu Thr Met Leu Phe 
145                 150                 155             


<210>  102
<211>  471
<212>  DNA
<213>  Homo sapiens

<220>
<223>  hIL-36b full length

<400>  102
atgaacccac aacgggaggc agcacccaaa tcctatgcta ttcgtgattc tcgacagatg       60

gtgtgggtcc tgagtggaaa ttctttaata gcagctcctc ttagccgcag cattaagcct      120

gtcactcttc atttaatagc ctgtagagac acagaattca gtgacaagga aaagggtaat      180

atggtttacc tgggaatcaa gggaaaagat ctctgtctct tctgtgcaga aattcagggc      240

aagcctactt tgcagcttaa ggaaaaaaat atcatggacc tgtatgtgga gaagaaagca      300

cagaagccct ttctcttttt ccacaataaa gaaggctcca cttctgtctt tcagtcagtc      360

tcttaccctg gctggttcat agccacctcc accacatcag gacagcccat ctttctcacc      420

aaggagagag gcataactaa taacactaac ttctacttag attctgtgga a               471


<210>  103
<211>  507
<212>  DNA
<213>  Homo sapiens

<220>
<223>  hIL-36g full length

<400>  103
atgagaggca ctccaggaga cgctgatggt ggaggaaggg ccgtctatca atcaatgtgt       60

aaacctatta ctgggactat taatgatttg aatcagcaag tgtggaccct tcagggtcag      120

aaccttgtgg cagttccacg aagtgacagt gtgaccccag tcactgttgc tgttatcaca      180

tgcaagtatc cagaggctct tgagcaaggc agaggggatc ccatttattt gggaatccag      240

aatccagaaa tgtgtttgta ttgtgagaag gttggagaac agcccacatt gcagctaaaa      300

gagcagaaga tcatggatct gtatggccaa cccgagcccg tgaaaccctt ccttttctac      360

cgtgccaaga ctggtaggac ctccaccctt gagtctgtgg ccttcccgga ctggttcatt      420

gcctcctcca agagagacca gcccatcatt ctgacttcag aacttgggaa gtcatacaac      480

actgcctttg aattaaatat aaatgac                                          507


<210>  104
<211>  456
<212>  DNA
<213>  Homo sapiens

<220>
<223>  hIL-36g truncated

<400>  104
tcaatgtgta aacctattac tgggactatt aatgatttga atcagcaagt gtggaccctt       60

cagggtcaga accttgtggc agttccacga agtgacagtg tgaccccagt cactgttgct      120

gttatcacat gcaagtatcc agaggctctt gagcaaggca gaggggatcc catttatttg      180

ggaatccaga atccagaaat gtgtttgtat tgtgagaagg ttggagaaca gcccacattg      240

cagctaaaag agcagaagat catggatctg tatggccaac ccgagcccgt gaaacccttc      300

cttttctacc gtgccaagac tggtaggacc tccacccttg agtctgtggc cttcccggac      360

tggttcattg cctcctccaa gagagaccag cccatcattc tgacttcaga acttgggaag      420

tcatacaaca ctgcctttga attaaatata aatgac                                456


<210>  105
<211>  465
<212>  DNA
<213>  Homo sapiens

<220>
<223>  hIL-36Ra full length

<400>  105
atggtcctga gtggggcgct gtgcttccga atgaaggact cggcattgaa ggtgctttat       60

ctgcataata accagcttct agctggaggg ctgcatgcag ggaaggtcat taaaggtgaa      120

gagatcagcg tggtccccaa tcggtggctg gatgccagcc tgtcccccgt catcctgggt      180

gtccagggtg gaagccagtg cctgtcatgt ggggtggggc aggagccgac tctaacacta      240

gagccagtga acatcatgga gctctatctt ggtgccaagg aatccaagag cttcaccttc      300

taccggcggg acatggggct cacctccagc ttcgagtcgg ctgcctaccc gggctggttc      360

ctgtgcacgg tgcctgaagc cgatcagcct gtcagactca cccagcttcc cgagaatggt      420

ggctggaatg cccccatcac agacttctac ttccagcagt gtgac                      465


<210>  106
<211>  155
<212>  PRT
<213>  Homo sapiens

<220>
<223>  hIL-36Ra full length

<400>  106

Met Val Leu Ser Gly Ala Leu Cys Phe Arg Met Lys Asp Ser Ala Leu 
1               5                   10                  15      


Lys Val Leu Tyr Leu His Asn Asn Gln Leu Leu Ala Gly Gly Leu His 
            20                  25                  30          


Ala Gly Lys Val Ile Lys Gly Glu Glu Ile Ser Val Val Pro Asn Arg 
        35                  40                  45              


Trp Leu Asp Ala Ser Leu Ser Pro Val Ile Leu Gly Val Gln Gly Gly 
    50                  55                  60                  


Ser Gln Cys Leu Ser Cys Gly Val Gly Gln Glu Pro Thr Leu Thr Leu 
65                  70                  75                  80  


Glu Pro Val Asn Ile Met Glu Leu Tyr Leu Gly Ala Lys Glu Ser Lys 
                85                  90                  95      


Ser Phe Thr Phe Tyr Arg Arg Asp Met Gly Leu Thr Ser Ser Phe Glu 
            100                 105                 110         


Ser Ala Ala Tyr Pro Gly Trp Phe Leu Cys Thr Val Pro Glu Ala Asp 
        115                 120                 125             


Gln Pro Val Arg Leu Thr Gln Leu Pro Glu Asn Gly Gly Trp Asn Ala 
    130                 135                 140                 


Pro Ile Thr Asp Phe Tyr Phe Gln Gln Cys Asp 
145                 150                 155 


<210>  107
<211>  462
<212>  DNA
<213>  Homo sapiens

<220>
<223>  hIL-36Ra truncated

<400>  107
gtcctgagtg gggcgctgtg cttccgaatg aaggactcgg cattgaaggt gctttatctg       60

cataataacc agcttctagc tggagggctg catgcaggga aggtcattaa aggtgaagag      120

atcagcgtgg tccccaatcg gtggctggat gccagcctgt cccccgtcat cctgggtgtc      180

cagggtggaa gccagtgcct gtcatgtggg gtggggcagg agccgactct aacactagag      240

ccagtgaaca tcatggagct ctatcttggt gccaaggaat ccaagagctt caccttctac      300

cggcgggaca tggggctcac ctccagcttc gagtcggctg cctacccggg ctggttcctg      360

tgcacggtgc ctgaagccga tcagcctgtc agactcaccc agcttcccga gaatggtggc      420

tggaatgccc ccatcacaga cttctacttc cagcagtgtg ac                         462


<210>  108
<211>  537
<212>  DNA
<213>  Cyno

<220>
<223>  cyIL-36a full length

<400>  108
atgaaaaaat tcattgttgt actatatgga aaactcaggc tgtgttcatg gtctttgagt       60

gaactatttt caatgtcgaa aagtgaaatg cctcagccgg tgagcattca ggatatcaat      120

catcgggtgt gggttcttca ggaccagatc ctcatagcag tcccgaggaa ggaccgtgtg      180

tctccagtca ctatttcctt aatctcatgc cgacatgtgg agacccttga gaaagacaga      240

gggaacccca tctacctggg actgaatggg ctcaatctct gcttgatgtg tgctaaggcc      300

ggggaccagc ccacactgca gctgaaggaa aaggatataa tggatttgta caaccaacct      360

gagcctgtga agtcctttct cttctaccac agccagagtg gcaggaactc caccttcgag      420

tctgtggcct tccctggctg gttcattgct gtcagctctg aaggaggctg tcctctcatc      480

cttacccaag aactggggaa agccaacact actgactttg ggttaactat gctgttt         537


<210>  109
<211>  179
<212>  PRT
<213>  Cyno

<220>
<223>  cyIL-36a full length

<400>  109

Met Lys Lys Phe Ile Val Val Leu Tyr Gly Lys Leu Arg Leu Cys Ser 
1               5                   10                  15      


Trp Ser Leu Ser Glu Leu Phe Ser Met Ser Lys Ser Glu Met Pro Gln 
            20                  25                  30          


Pro Val Ser Ile Gln Asp Ile Asn His Arg Val Trp Val Leu Gln Asp 
        35                  40                  45              


Gln Ile Leu Ile Ala Val Pro Arg Lys Asp Arg Val Ser Pro Val Thr 
    50                  55                  60                  


Ile Ser Leu Ile Ser Cys Arg His Val Glu Thr Leu Glu Lys Asp Arg 
65                  70                  75                  80  


Gly Asn Pro Ile Tyr Leu Gly Leu Asn Gly Leu Asn Leu Cys Leu Met 
                85                  90                  95      


Cys Ala Lys Ala Gly Asp Gln Pro Thr Leu Gln Leu Lys Glu Lys Asp 
            100                 105                 110         


Ile Met Asp Leu Tyr Asn Gln Pro Glu Pro Val Lys Ser Phe Leu Phe 
        115                 120                 125             


Tyr His Ser Gln Ser Gly Arg Asn Ser Thr Phe Glu Ser Val Ala Phe 
    130                 135                 140                 


Pro Gly Trp Phe Ile Ala Val Ser Ser Glu Gly Gly Cys Pro Leu Ile 
145                 150                 155                 160 


Leu Thr Gln Glu Leu Gly Lys Ala Asn Thr Thr Asp Phe Gly Leu Thr 
                165                 170                 175     


Met Leu Phe 
            


<210>  110
<211>  471
<212>  DNA
<213>  Cyno

<220>
<223>  cyIL-36b full length

<400>  110
atgaacccac aatggcaggc agcacccaaa tcctatgcta ttcgtgattc tcgacagatg       60

gtgtgggtcc tgagtggaaa ttctttaata gcagctcctc ttagcaaccg tgttaagcct      120

gtcactcttc atttaataac ctgcagagac acagaattca gtgataagaa aaagggtaat      180

ctggtttacc tgggaatcag gggaaaagat ctctgtctct tctgtgaaga aattcagggc      240

aaacctactt tgcagcttaa ggagaaaaac atcatggacc tgtacatgga gaagaaagca      300

cagaagccct ttctcttttt ccacaataaa gaaggctcca gttctgtctt tcagtcagtc      360

tcttaccctg gctggttcat agccacctcc tccacatcag gacagcccat ctttctcacc      420

caggagaggg gcataactaa caacactaac ttctacttag attctgtgga a               471


<210>  111
<211>  157
<212>  PRT
<213>  Cyno

<220>
<223>  cyIL-36b full length

<400>  111

Met Asn Pro Gln Trp Gln Ala Ala Pro Lys Ser Tyr Ala Ile Arg Asp 
1               5                   10                  15      


Ser Arg Gln Met Val Trp Val Leu Ser Gly Asn Ser Leu Ile Ala Ala 
            20                  25                  30          


Pro Leu Ser Asn Arg Val Lys Pro Val Thr Leu His Leu Ile Thr Cys 
        35                  40                  45              


Arg Asp Thr Glu Phe Ser Asp Lys Lys Lys Gly Asn Leu Val Tyr Leu 
    50                  55                  60                  


Gly Ile Arg Gly Lys Asp Leu Cys Leu Phe Cys Glu Glu Ile Gln Gly 
65                  70                  75                  80  


Lys Pro Thr Leu Gln Leu Lys Glu Lys Asn Ile Met Asp Leu Tyr Met 
                85                  90                  95      


Glu Lys Lys Ala Gln Lys Pro Phe Leu Phe Phe His Asn Lys Glu Gly 
            100                 105                 110         


Ser Ser Ser Val Phe Gln Ser Val Ser Tyr Pro Gly Trp Phe Ile Ala 
        115                 120                 125             


Thr Ser Ser Thr Ser Gly Gln Pro Ile Phe Leu Thr Gln Glu Arg Gly 
    130                 135                 140                 


Ile Thr Asn Asn Thr Asn Phe Tyr Leu Asp Ser Val Glu 
145                 150                 155         


<210>  112
<211>  504
<212>  DNA
<213>  Cyno

<220>
<223>  cyIL-36g full length

<400>  112
atgagaggca ctccaggaaa ccctgctggt ggaggaaggg tcgtctatca gtcaatgcgt       60

acacctatta ctgggactat taatgatttg aatcagcaag tgtggaccct tcagggtcag      120

atccttgtgg cagttccacg aagtgacagt gtgaccccag tcactgtcgc tgttatcaca      180

tgcaagtatc cagaggctct tgaccaaagc agaggggatc ccatttattt gggaatccgg      240

aatccagaaa tgtgtttgtg ttgtgaggag gttggaggac agcccacgtt gcagctaaaa      300

gagcagaaga tcatggattt gtatggccag cccgagcctg tgaaaccctt ccttttctac      360

cgtgtcaaga ccggtaggac ctccaccctt gagtctgtgg ccttcccaaa ctggttcatt      420

gcctcttcca cgagagacca gcccatcatc ctgacttcag aacttgggaa gtcatacaac      480

actgcctttg aattaaatat aaaa                                             504


<210>  113
<211>  168
<212>  PRT
<213>  Cyno

<220>
<223>  cyIL-36g full length

<400>  113

Met Arg Gly Thr Pro Gly Asn Pro Ala Gly Gly Gly Arg Val Val Tyr 
1               5                   10                  15      


Gln Ser Met Arg Thr Pro Ile Thr Gly Thr Ile Asn Asp Leu Asn Gln 
            20                  25                  30          


Gln Val Trp Thr Leu Gln Gly Gln Ile Leu Val Ala Val Pro Arg Ser 
        35                  40                  45              


Asp Ser Val Thr Pro Val Thr Val Ala Val Ile Thr Cys Lys Tyr Pro 
    50                  55                  60                  


Glu Ala Leu Asp Gln Ser Arg Gly Asp Pro Ile Tyr Leu Gly Ile Arg 
65                  70                  75                  80  


Asn Pro Glu Met Cys Leu Cys Cys Glu Glu Val Gly Gly Gln Pro Thr 
                85                  90                  95      


Leu Gln Leu Lys Glu Gln Lys Ile Met Asp Leu Tyr Gly Gln Pro Glu 
            100                 105                 110         


Pro Val Lys Pro Phe Leu Phe Tyr Arg Val Lys Thr Gly Arg Thr Ser 
        115                 120                 125             


Thr Leu Glu Ser Val Ala Phe Pro Asn Trp Phe Ile Ala Ser Ser Thr 
    130                 135                 140                 


Arg Asp Gln Pro Ile Ile Leu Thr Ser Glu Leu Gly Lys Ser Tyr Asn 
145                 150                 155                 160 


Thr Ala Phe Glu Leu Asn Ile Lys 
                165             


<210>  114
<211>  109
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  144D464A LV0

<400>  114

Gln Ala Val Val Thr Gln Glu Pro Ser Leu Thr Val Ser Pro Gly Gly 
1               5                   10                  15      


Thr Val Thr Leu Thr Cys Arg Ser Ser Ser Gly Ala Val Thr Thr Ser 
            20                  25                  30          


Asn Tyr Ala Asn Trp Phe Gln Gln Lys Pro Gly Gln Ala Pro Arg Thr 
        35                  40                  45              


Leu Ile Ser Gly Thr Asn Asp Arg Ala Pro Trp Thr Pro Ala Arg Phe 
    50                  55                  60                  


Ser Gly Ser Leu Leu Gly Gly Lys Ala Ala Leu Thr Leu Ser Gly Ala 
65                  70                  75                  80  


Gln Pro Glu Asp Glu Ala Asp Tyr Phe Cys Ala Leu Trp Phe Ser Asn 
                85                  90                  95      


His Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105                 


<210>  115
<211>  121
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  144D464A HV0

<400>  115

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asp Thr 
            20                  25                  30          


Tyr Ile His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Arg Ile Asp Pro Ala Ile Gly Thr Thr Arg Tyr Asp Pro Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Ile Thr Ala Asp Thr Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Leu His Tyr Phe Gly Asn Asn Phe Phe Phe Asp Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120     


<210>  116
<211>  109
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  144D464A LV3a

<400>  116

Gln Ala Val Val Thr Gln Glu Pro Ser Leu Thr Val Ser Pro Gly Gly 
1               5                   10                  15      


Thr Val Thr Leu Thr Cys Arg Ser Ser Ser Gly Ala Val Thr Thr Ser 
            20                  25                  30          


Asn Tyr Ala Asn Trp Phe Gln Gln Lys Pro Gly Gln Ala Pro Arg Gly 
        35                  40                  45              


Leu Ile Ser Gly Thr Asn Asp Arg Ala Pro Trp Val Pro Ala Arg Phe 
    50                  55                  60                  


Ser Gly Ser Leu Leu Gly Gly Lys Ala Ala Leu Thr Ile Ser Gly Ala 
65                  70                  75                  80  


Gln Pro Glu Asp Glu Ala Asp Tyr Phe Cys Ala Leu Trp Phe Ser Asn 
                85                  90                  95      


His Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105                 


<210>  117
<211>  109
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  144D464A LV3b

<400>  117

Gln Ala Val Val Thr Gln Glu Pro Ser Leu Thr Val Ser Pro Gly Gly 
1               5                   10                  15      


Thr Val Thr Leu Thr Cys Arg Ser Ser Ser Gly Ala Val Thr Thr Ser 
            20                  25                  30          


Asn Tyr Ala Asn Trp Val Gln Gln Lys Pro Gly Gln Ala Pro Arg Gly 
        35                  40                  45              


Leu Ile Ser Gly Thr Asn Asp Arg Ala Pro Trp Val Pro Ala Arg Phe 
    50                  55                  60                  


Ser Gly Ser Leu Leu Gly Gly Lys Ala Ala Leu Thr Leu Ser Gly Ala 
65                  70                  75                  80  


Gln Pro Glu Asp Glu Ala Asp Tyr Phe Cys Ala Leu Trp Phe Ser Asn 
                85                  90                  95      


His Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105                 


<210>  118
<211>  109
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  144D464A LV4a

<400>  118

Gln Ala Val Val Thr Gln Glu Pro Ser Leu Thr Val Ser Pro Gly Gly 
1               5                   10                  15      


Thr Val Thr Leu Thr Cys Arg Ser Ser Ser Gly Ala Val Thr Thr Ser 
            20                  25                  30          


Asn Tyr Ala Asn Trp Val Gln Gln Lys Pro Gly Gln Ala Pro Arg Gly 
        35                  40                  45              


Leu Ile Ser Gly Thr Asn Asp Arg Ala Pro Trp Val Pro Ala Arg Phe 
    50                  55                  60                  


Ser Gly Ser Leu Leu Gly Gly Lys Ala Ala Leu Thr Ile Ser Gly Ala 
65                  70                  75                  80  


Gln Pro Glu Asp Glu Ala Asp Tyr Phe Cys Ala Leu Trp Phe Ser Asn 
                85                  90                  95      


His Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105                 


<210>  119
<211>  109
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  144D464A LV4b

<400>  119

Gln Ala Val Val Thr Gln Glu Pro Ser Leu Thr Val Ser Pro Gly Gly 
1               5                   10                  15      


Thr Val Thr Leu Thr Cys Arg Ser Ser Ser Gly Ala Val Thr Thr Ser 
            20                  25                  30          


Asn Tyr Ala Asn Trp Val Gln Gln Lys Pro Gly Gln Ala Pro Arg Gly 
        35                  40                  45              


Leu Ile Gly Gly Thr Asn Asp Arg Ala Pro Trp Val Pro Ala Arg Phe 
    50                  55                  60                  


Ser Gly Ser Leu Leu Gly Gly Lys Ala Ala Leu Thr Leu Ser Gly Ala 
65                  70                  75                  80  


Gln Pro Glu Asp Glu Ala Asp Tyr Phe Cys Ala Leu Trp Phe Ser Asn 
                85                  90                  95      


His Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105                 


<210>  120
<211>  109
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  144D464A LV5a

<400>  120

Gln Ala Val Val Thr Gln Glu Pro Ser Leu Thr Val Ser Pro Gly Gly 
1               5                   10                  15      


Thr Val Thr Leu Thr Cys Arg Ser Ser Ser Gly Ala Val Thr Thr Ser 
            20                  25                  30          


Asn Tyr Ala Asn Trp Val Gln Gln Lys Pro Gly Gln Ala Pro Ala Gly 
        35                  40                  45              


Leu Ile Gly Gly Thr Asn Asp Arg Ala Pro Trp Val Pro Ala Arg Phe 
    50                  55                  60                  


Ser Gly Ser Leu Leu Gly Gly Lys Ala Ala Leu Thr Leu Ser Gly Ala 
65                  70                  75                  80  


Gln Pro Glu Asp Glu Ala Asp Tyr Phe Cys Ala Leu Trp Phe Ser Asn 
                85                  90                  95      


His Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105                 


<210>  121
<211>  109
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  144D464A LV5b

<400>  121

Gln Ala Val Val Thr Gln Glu Pro Ser Leu Thr Val Ser Pro Gly Gly 
1               5                   10                  15      


Thr Val Thr Leu Thr Cys Arg Ser Ser Ser Gly Ala Val Thr Thr Ser 
            20                  25                  30          


Asn Tyr Ala Asn Trp Val Gln Gln Lys Pro Gly Gln Leu Phe Ala Thr 
        35                  40                  45              


Leu Ile Ser Gly Thr Asn Asp Arg Ala Pro Trp Thr Pro Ala Arg Phe 
    50                  55                  60                  


Ser Gly Ser Leu Leu Gly Gly Lys Ala Ala Leu Thr Leu Ser Gly Ala 
65                  70                  75                  80  


Gln Pro Glu Asp Glu Ala Ile Tyr Phe Cys Ala Leu Trp Phe Ser Asn 
                85                  90                  95      


His Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105                 


<210>  122
<211>  109
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  144D464A LV5c

<400>  122

Gln Ala Val Val Thr Gln Glu Pro Ser Leu Thr Val Ser Pro Gly Gly 
1               5                   10                  15      


Thr Val Thr Leu Thr Cys Arg Ser Ser Ser Gly Ala Val Thr Thr Ser 
            20                  25                  30          


Asn Tyr Ala Asn Trp Val Gln Glu Lys Pro Gly Gln Ala Pro Arg Gly 
        35                  40                  45              


Leu Ile Ser Gly Thr Asn Asp Arg Ala Pro Trp Val Pro Ala Arg Phe 
    50                  55                  60                  


Ser Gly Ser Leu Leu Gly Gly Lys Ala Ala Leu Thr Ile Ser Gly Ala 
65                  70                  75                  80  


Gln Pro Glu Asp Glu Ala Asp Tyr Phe Cys Ala Leu Trp Phe Ser Asn 
                85                  90                  95      


His Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105                 


<210>  123
<211>  109
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  144D464A LV5d

<400>  123

Gln Ala Val Val Thr Gln Glu Pro Ser Leu Thr Val Ser Pro Gly Gly 
1               5                   10                  15      


Thr Val Thr Leu Thr Cys Arg Ser Ser Ser Gly Ala Val Thr Thr Ser 
            20                  25                  30          


Asn Tyr Ala Asn Trp Val Gln Glu Lys Pro Gly Gln Ala Phe Arg Gly 
        35                  40                  45              


Leu Ile Ser Gly Thr Asn Asp Arg Ala Pro Trp Val Pro Ala Arg Phe 
    50                  55                  60                  


Ser Gly Ser Leu Leu Gly Gly Lys Ala Ala Leu Thr Leu Ser Gly Ala 
65                  70                  75                  80  


Gln Pro Glu Asp Glu Ala Asp Tyr Phe Cys Ala Leu Trp Phe Ser Asn 
                85                  90                  95      


His Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105                 


<210>  124
<211>  109
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  144D464A LV5e

<400>  124

Gln Ala Val Val Thr Gln Glu Pro Ser Leu Thr Thr Ser Pro Gly Gly 
1               5                   10                  15      


Thr Val Thr Leu Thr Cys Arg Ser Ser Ser Gly Ala Val Thr Thr Ser 
            20                  25                  30          


Asn Tyr Ala Asn Trp Val Gln Gln Lys Pro Gly Gln Ala Pro Arg Gly 
        35                  40                  45              


Leu Ile Gly Gly Thr Asn Asp Arg Ala Pro Trp Val Pro Ala Arg Phe 
    50                  55                  60                  


Ser Gly Ser Leu Leu Gly Gly Lys Ala Ala Leu Thr Leu Ser Gly Ala 
65                  70                  75                  80  


Gln Pro Glu Asp Glu Ala Asp Tyr Phe Cys Ala Leu Trp Phe Ser Asn 
                85                  90                  95      


His Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105                 


<210>  125
<211>  109
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  144D464A LV6a

<400>  125

Gln Ala Val Val Thr Gln Glu Pro Ser Leu Thr Val Ser Pro Gly Gly 
1               5                   10                  15      


Thr Val Thr Leu Thr Cys Arg Ser Ser Ser Gly Ala Val Thr Thr Ser 
            20                  25                  30          


Asn Tyr Ala Asn Trp Phe Gln Gln Lys Pro Gly Gln Leu Phe Ala Gly 
        35                  40                  45              


Leu Ile Ser Gly Thr Asn Asp Arg Ala Pro Gly Thr Pro Ala Arg Phe 
    50                  55                  60                  


Ser Gly Ser Leu Leu Gly Gly Lys Ala Ala Leu Thr Leu Ser Gly Ala 
65                  70                  75                  80  


Gln Pro Glu Asp Glu Ala Ile Tyr Phe Cys Ala Leu Trp Phe Ser Asn 
                85                  90                  95      


His Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105                 


<210>  126
<211>  109
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  144D464A LV6b

<400>  126

Gln Ala Val Val Thr Gln Glu Pro Ser Leu Thr Val Ser Pro Gly Gly 
1               5                   10                  15      


Thr Val Thr Leu Thr Cys Arg Ser Ser Ser Gly Ala Val Thr Thr Ser 
            20                  25                  30          


Asn Tyr Ala Asn Trp Val Gln Gln Lys Pro Gly Gln Ala Pro Ala Gly 
        35                  40                  45              


Leu Ile Gly Gly Thr Asn Asp Arg Ala Pro Gly Val Pro Ala Arg Phe 
    50                  55                  60                  


Ser Gly Ser Leu Leu Gly Gly Lys Ala Ala Leu Thr Leu Ser Gly Ala 
65                  70                  75                  80  


Gln Pro Glu Asp Glu Ala Asp Tyr Phe Cys Ala Leu Trp Phe Ser Asn 
                85                  90                  95      


His Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105                 


<210>  127
<211>  109
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  144D464A LV6c

<400>  127

Gln Ala Val Val Thr Gln Glu Pro Ser Leu Thr Val Ser Pro Gly Gly 
1               5                   10                  15      


Thr Val Thr Leu Thr Cys Arg Ser Ser Ser Gly Ala Val Thr Thr Ser 
            20                  25                  30          


Asn Tyr Ala Asn Trp Val Gln Gln Lys Pro Gly Gln Leu Phe Ala Gly 
        35                  40                  45              


Leu Ile Gly Gly Thr Asn Asp Arg Ala Pro Trp Thr Pro Ala Arg Phe 
    50                  55                  60                  


Ser Gly Ser Leu Leu Gly Gly Lys Ala Ala Leu Thr Leu Ser Gly Ala 
65                  70                  75                  80  


Gln Pro Glu Asp Glu Ala Asp Tyr Phe Cys Ala Leu Trp Phe Ser Asn 
                85                  90                  95      


His Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105                 


<210>  128
<211>  109
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  144D464A LV6d

<400>  128

Gln Ala Val Val Thr Gln Glu Pro Ser Leu Thr Thr Ser Pro Gly Gly 
1               5                   10                  15      


Thr Val Thr Leu Thr Cys Arg Ser Ser Ser Gly Ala Val Thr Thr Ser 
            20                  25                  30          


Asn Tyr Ala Asn Trp Phe Gln Gln Lys Pro Gly Gln Ala Pro Arg Gly 
        35                  40                  45              


Leu Ile Gly Gly Thr Asn Asp Arg Ala Pro Trp Val Pro Ala Arg Phe 
    50                  55                  60                  


Ser Gly Ser Leu Leu Gly Gly Lys Ala Ala Leu Thr Ile Ser Gly Ala 
65                  70                  75                  80  


Gln Pro Glu Asp Glu Ala Ile Tyr Phe Cys Ala Leu Trp Phe Ser Asn 
                85                  90                  95      


His Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105                 


<210>  129
<211>  109
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  144D464A LV6e

<400>  129

Gln Ala Val Val Thr Gln Glu Pro Ser Leu Thr Val Ser Pro Gly Gly 
1               5                   10                  15      


Thr Val Thr Leu Thr Cys Arg Ser Ser Ser Gly Ala Val Thr Thr Ser 
            20                  25                  30          


Asn Tyr Ala Asn Trp Val Gln Glu Lys Pro Gly Gln Ala Phe Arg Gly 
        35                  40                  45              


Leu Ile Gly Gly Thr Asn Asp Arg Ala Pro Trp Val Pro Ala Arg Phe 
    50                  55                  60                  


Ser Gly Ser Leu Leu Gly Gly Lys Ala Ala Leu Thr Leu Ser Gly Ala 
65                  70                  75                  80  


Gln Pro Glu Asp Glu Ala Asp Tyr Phe Cys Ala Leu Trp Phe Ser Asn 
                85                  90                  95      


His Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105                 


<210>  130
<211>  109
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  144D464A LV7a

<400>  130

Gln Ala Val Val Thr Gln Glu Pro Ser Leu Thr Val Ser Pro Gly Gly 
1               5                   10                  15      


Thr Val Thr Leu Thr Cys Arg Ser Ser Ser Gly Ala Val Thr Thr Ser 
            20                  25                  30          


Asn Tyr Ala Asn Trp Val Gln Gln Lys Pro Gly Gln Ala Phe Ala Gly 
        35                  40                  45              


Leu Ile Gly Gly Thr Asn Asp Arg Ala Pro Gly Val Pro Ala Arg Phe 
    50                  55                  60                  


Ser Gly Ser Leu Leu Gly Gly Lys Ala Ala Leu Thr Ile Ser Gly Ala 
65                  70                  75                  80  


Gln Pro Glu Asp Glu Ala Asp Tyr Phe Cys Ala Leu Trp Phe Ser Asn 
                85                  90                  95      


His Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105                 


<210>  131
<211>  109
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  144D464A LV7b

<400>  131

Gln Ala Val Val Thr Gln Glu Ser Ser Leu Thr Thr Ser Pro Gly Gly 
1               5                   10                  15      


Thr Val Thr Leu Thr Cys Arg Ser Ser Ser Gly Ala Val Thr Thr Ser 
            20                  25                  30          


Asn Tyr Ala Asn Trp Val Gln Gln Lys Pro Gly Gln Ala Pro Arg Gly 
        35                  40                  45              


Leu Ile Gly Gly Thr Asn Asp Arg Ala Pro Trp Val Pro Ala Arg Phe 
    50                  55                  60                  


Ser Gly Ser Leu Leu Gly Gly Lys Ala Ala Leu Thr Leu Ser Gly Ala 
65                  70                  75                  80  


Gln Pro Glu Asp Glu Ala Ile Tyr Phe Cys Ala Leu Trp Phe Ser Asn 
                85                  90                  95      


His Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105                 


<210>  132
<211>  109
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  144D464A LV8

<400>  132

Gln Ala Val Val Thr Gln Glu Pro Ser Leu Thr Thr Ser Pro Gly Gly 
1               5                   10                  15      


Thr Val Thr Leu Thr Cys Arg Ser Ser Ser Gly Ala Val Thr Thr Ser 
            20                  25                  30          


Asn Tyr Ala Asn Trp Phe Gln Gln Lys Pro Gly Gln Leu Pro Ala Gly 
        35                  40                  45              


Leu Ile Gly Gly Thr Asn Asp Arg Ala Pro Trp Val Pro Ala Arg Phe 
    50                  55                  60                  


Ser Gly Ser Leu Leu Gly Gly Lys Ala Ala Leu Thr Ile Ser Gly Ala 
65                  70                  75                  80  


Gln Pro Glu Asp Glu Ala Ile Tyr Phe Cys Ala Leu Trp Phe Ser Asn 
                85                  90                  95      


His Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105                 


<210>  133
<211>  109
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  144D464A LV9

<400>  133

Gln Ala Val Val Thr Gln Glu Pro Ser Leu Thr Thr Ser Pro Gly Gly 
1               5                   10                  15      


Thr Val Thr Leu Thr Cys Arg Ser Ser Ser Gly Ala Val Thr Thr Ser 
            20                  25                  30          


Asn Tyr Ala Asn Trp Val Gln Glu Lys Pro Gly Gln Ala Phe Arg Gly 
        35                  40                  45              


Leu Ile Gly Gly Thr Asn Asp Arg Ala Pro Trp Val Pro Ala Arg Phe 
    50                  55                  60                  


Ser Gly Ser Leu Leu Gly Gly Lys Ala Ala Leu Thr Ile Ser Gly Ala 
65                  70                  75                  80  


Gln Pro Glu Asp Glu Ala Ile Tyr Phe Cys Ala Leu Trp Phe Ser Asn 
                85                  90                  95      


His Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105                 


<210>  134
<211>  109
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  144D464A LV11

<400>  134

Gln Ala Val Val Thr Gln Glu Ser Ser Leu Thr Thr Ser Pro Gly Gly 
1               5                   10                  15      


Thr Val Thr Leu Thr Cys Arg Ser Ser Ser Gly Ala Val Thr Thr Ser 
            20                  25                  30          


Asn Tyr Ala Asn Trp Val Gln Gln Lys Pro Gly Gln Leu Phe Ala Gly 
        35                  40                  45              


Leu Ile Gly Gly Thr Asn Asp Arg Ala Pro Gly Val Pro Ala Arg Phe 
    50                  55                  60                  


Ser Gly Ser Leu Leu Gly Gly Lys Ala Ala Leu Thr Leu Ser Gly Ala 
65                  70                  75                  80  


Gln Pro Glu Asp Glu Ala Ile Tyr Phe Cys Ala Leu Trp Phe Ser Asn 
                85                  90                  95      


His Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105                 


<210>  135
<211>  109
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  144D464A LV12(+1)

<400>  135

Gln Ala Val Val Thr Gln Glu Ser Ser Leu Thr Thr Ser Pro Gly Gly 
1               5                   10                  15      


Thr Val Thr Leu Thr Cys Arg Ser Ser Ser Gly Ala Val Thr Thr Ser 
            20                  25                  30          


Asn Tyr Ala Asn Trp Val Gln Glu Lys Pro Gly Gln Leu Phe Ala Gly 
        35                  40                  45              


Leu Ile Gly Gly Thr Asn Asp Arg Ala Pro Gly Val Pro Ala Arg Phe 
    50                  55                  60                  


Ser Gly Ser Leu Leu Gly Gly Lys Ala Ala Leu Thr Ile Ser Gly Ala 
65                  70                  75                  80  


Gln Pro Glu Asp Glu Ala Ile Tyr Phe Cys Ala Leu Trp Phe Ser Asn 
                85                  90                  95      


His Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105                 


<210>  136
<211>  109
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  144D464A LV9are

<400>  136

Gln Ala Val Val Thr Gln Glu Pro Ser Leu Thr Val Ser Pro Gly Gly 
1               5                   10                  15      


Thr Val Thr Leu Thr Cys Arg Ser Ser Ser Gly Ala Val Thr Thr Ser 
            20                  25                  30          


Asn Tyr Ala Asn Trp Val Gln Glu Lys Pro Gly Gln Leu Phe Ala Gly 
        35                  40                  45              


Leu Ile Gly Gly Thr Asn Asp Arg Ala Pro Gly Val Pro Ala Arg Phe 
    50                  55                  60                  


Ser Gly Ser Leu Leu Gly Gly Lys Ala Ala Leu Thr Leu Ser Gly Ala 
65                  70                  75                  80  


Gln Pro Glu Asp Glu Ala Asp Tyr Phe Cys Ala Leu Trp Phe Ser Asn 
                85                  90                  95      


His Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105                 


<210>  137
<211>  109
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  144D464A LV10re

<400>  137

Gln Ala Val Val Thr Gln Glu Pro Ser Leu Thr Val Ser Pro Gly Gly 
1               5                   10                  15      


Thr Val Thr Leu Thr Cys Arg Ser Ser Ser Gly Ala Val Thr Thr Ser 
            20                  25                  30          


Asn Tyr Ala Asn Trp Val Gln Glu Lys Pro Gly Gln Leu Phe Ala Gly 
        35                  40                  45              


Leu Ile Gly Gly Thr Asn Asp Arg Ala Pro Gly Val Pro Ala Arg Phe 
    50                  55                  60                  


Ser Gly Ser Leu Leu Gly Gly Lys Ala Ala Leu Thr Leu Ser Gly Ala 
65                  70                  75                  80  


Gln Pro Glu Asp Glu Ala Ile Tyr Phe Cys Ala Leu Trp Phe Ser Asn 
                85                  90                  95      


His Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105                 


<210>  138
<211>  109
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  144D464A LV11re

<400>  138

Gln Ala Val Val Thr Gln Glu Pro Ser Leu Thr Val Ser Pro Gly Gly 
1               5                   10                  15      


Thr Val Thr Leu Thr Cys Arg Ser Ser Ser Gly Ala Val Thr Thr Ser 
            20                  25                  30          


Asn Tyr Ala Asn Trp Val Gln Glu Lys Pro Gly Gln Leu Phe Ala Gly 
        35                  40                  45              


Leu Ile Gly Gly Thr Asn Asp Arg Ala Pro Gly Val Pro Ala Arg Phe 
    50                  55                  60                  


Ser Gly Ser Leu Leu Gly Gly Lys Ala Ala Leu Thr Ile Ser Gly Ala 
65                  70                  75                  80  


Gln Pro Glu Asp Glu Ala Ile Tyr Phe Cys Ala Leu Trp Phe Ser Asn 
                85                  90                  95      


His Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105                 


<210>  139
<211>  121
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  144D464A HV1

<400>  139

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asp Thr 
            20                  25                  30          


Tyr Ile His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Arg Ile Asp Pro Ala Ile Gly Thr Thr Arg Tyr Asp Pro Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Ile Thr Ala Asp Thr Ser Thr Asp Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Leu His Tyr Phe Gly Asn Asn Phe Phe Phe Asp Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120     


<210>  140
<211>  121
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  144D464A HV4a

<400>  140

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asp Thr 
            20                  25                  30          


Tyr Ile His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Arg Ile Asp Pro Ala Ile Gly Thr Thr Arg Tyr Asp Pro Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Ile Thr Thr Asp Thr Ser Thr Asp Thr Val Tyr 
65                  70                  75                  80  


Met Glu Phe Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Leu His Tyr Phe Gly Asn Asn Phe Phe Phe Asp Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120     


<210>  141
<211>  121
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  144D464A HV4b

<400>  141

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Asn Phe Lys Asp Thr 
            20                  25                  30          


Tyr Ile His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Arg Ile Asp Pro Ala Ile Gly Thr Thr Arg Tyr Asp Pro Lys Phe 
    50                  55                  60                  


Gln Gly Arg Ala Thr Ile Thr Ala Asp Thr Ser Thr Ser Thr Val Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Leu His Tyr Phe Gly Asn Asn Phe Phe Phe Asp Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120     


<210>  142
<211>  121
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  144D464A HV4c

<400>  142

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Phe Asn Ile Lys Asp Thr 
            20                  25                  30          


Tyr Ile His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Arg Ile Asp Pro Ala Ile Gly Thr Thr Arg Tyr Asp Pro Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Ile Thr Ala Asp Thr Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Leu His Tyr Phe Gly Asn Asn Phe Phe Phe Asp Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120     


<210>  143
<211>  121
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  144D464A HV5a

<400>  143

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Asn Phe Lys Asp Thr 
            20                  25                  30          


Tyr Ile His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Arg Ile Asp Pro Ala Ile Gly Thr Thr Arg Tyr Asp Pro Lys Phe 
    50                  55                  60                  


Gln Gly Lys Ala Thr Ile Thr Thr Asp Thr Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Leu His Tyr Phe Gly Asn Asn Phe Phe Phe Asp Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120     


<210>  144
<211>  121
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  144D464A HV5b

<400>  144

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Phe Thr Phe Lys Asp Thr 
            20                  25                  30          


Tyr Ile His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Arg Ile Asp Pro Ala Ile Gly Thr Thr Arg Tyr Asp Pro Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Ile Thr Thr Asp Thr Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Leu His Tyr Phe Gly Asn Asn Phe Phe Phe Asp Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120     


<210>  145
<211>  121
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  144D464A HV5c

<400>  145

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Asn Phe Lys Asp Thr 
            20                  25                  30          


Tyr Ile His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Arg Ile Asp Pro Ala Ile Gly Thr Thr Arg Tyr Asp Pro Lys Phe 
    50                  55                  60                  


Gln Gly Arg Ala Thr Ile Thr Ala Asp Thr Ser Thr Ser Thr Val Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Leu His Tyr Phe Gly Asn Asn Phe Phe Phe Asp Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120     


<210>  146
<211>  121
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  144D464A HV5d

<400>  146

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Asn Ile Lys Asp Thr 
            20                  25                  30          


Tyr Ile His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Arg Ile Asp Pro Ala Ile Gly Thr Thr Arg Tyr Asp Pro Lys Phe 
    50                  55                  60                  


Gln Gly Arg Ala Thr Ile Thr Ala Asp Thr Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Leu Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Leu His Tyr Phe Gly Asn Asn Phe Phe Phe Asp Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120     


<210>  147
<211>  121
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  144D464A HV5e

<400>  147

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Ile Lys Asp Thr 
            20                  25                  30          


Tyr Ile His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Arg Ile Asp Pro Ala Ile Gly Thr Thr Arg Tyr Asp Pro Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Ile Thr Ala Asp Thr Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Leu Glu Phe Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Leu His Tyr Phe Gly Asn Asn Phe Phe Phe Asp Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120     


<210>  148
<211>  121
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  144D464A HV5f

<400>  148

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Asn Ile Lys Asp Thr 
            20                  25                  30          


Tyr Ile His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Arg Ile Asp Pro Ala Ile Gly Thr Thr Arg Tyr Asp Pro Lys Phe 
    50                  55                  60                  


Gln Gly Arg Ala Thr Ile Thr Ala Asp Thr Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Leu His Tyr Phe Gly Asn Asn Phe Phe Phe Asp Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120     


<210>  149
<211>  121
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  144D464A HV5g

<400>  149

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Phe Thr Ile Lys Asp Thr 
            20                  25                  30          


Tyr Ile His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Arg Ile Asp Pro Ala Ile Gly Thr Thr Arg Tyr Asp Pro Lys Phe 
    50                  55                  60                  


Gln Gly Arg Ala Thr Ile Thr Thr Asp Thr Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Leu His Tyr Phe Gly Asn Asn Phe Phe Phe Asp Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120     


<210>  150
<211>  121
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  144D464A HV6a

<400>  150

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Asn Phe Lys Asp Thr 
            20                  25                  30          


Tyr Ile His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Arg Ile Asp Pro Ala Ile Gly Thr Thr Arg Tyr Asp Pro Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Ile Thr Thr Asp Thr Ser Thr Ser Thr Val Tyr 
65                  70                  75                  80  


Met Glu Phe Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Leu His Tyr Phe Gly Asn Asn Phe Phe Phe Asp Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120     


<210>  151
<211>  121
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  144D464A HV6b

<400>  151

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Asn Phe Lys Asp Thr 
            20                  25                  30          


Tyr Ile His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Arg Ile Asp Pro Ala Ile Gly Thr Thr Arg Tyr Asp Pro Lys Phe 
    50                  55                  60                  


Gln Gly Arg Ala Thr Ile Thr Ala Asp Thr Ser Thr Asp Thr Val Tyr 
65                  70                  75                  80  


Met Glu Phe Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Leu His Tyr Phe Gly Asn Asn Phe Phe Phe Asp Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120     


<210>  152
<211>  121
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  144D464A HV6c

<400>  152

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Ile Lys Asp Thr 
            20                  25                  30          


Tyr Ile His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Arg Ile Asp Pro Ala Ile Gly Thr Thr Arg Tyr Asp Pro Lys Phe 
    50                  55                  60                  


Gln Gly Arg Ala Thr Ile Thr Ala Asp Thr Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Leu Glu Phe Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Leu His Tyr Phe Gly Asn Asn Phe Phe Phe Asp Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120     


<210>  153
<211>  121
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  144D464A HV6d

<400>  153

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Phe Thr Ile Lys Asp Thr 
            20                  25                  30          


Tyr Ile His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Arg Ile Asp Pro Ala Ile Gly Thr Thr Arg Tyr Asp Pro Lys Phe 
    50                  55                  60                  


Gln Gly Arg Ala Thr Ile Thr Thr Asp Thr Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Leu His Tyr Phe Gly Asn Asn Phe Phe Phe Asp Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120     


<210>  154
<211>  121
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  144D464A HV6e

<400>  154

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Phe Thr Ile Lys Asp Thr 
            20                  25                  30          


Tyr Ile His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Arg Ile Asp Pro Ala Ile Gly Thr Thr Arg Tyr Asp Pro Lys Phe 
    50                  55                  60                  


Gln Gly Arg Ala Thr Ile Thr Thr Asp Thr Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Phe Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Leu His Tyr Phe Gly Asn Asn Phe Phe Phe Asp Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120     


<210>  155
<211>  121
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  144D464A HV7a

<400>  155

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Asn Ile Lys Asp Thr 
            20                  25                  30          


Tyr Ile His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Arg Ile Asp Pro Ala Ile Gly Thr Thr Arg Tyr Asp Pro Lys Phe 
    50                  55                  60                  


Gln Gly Arg Ala Thr Ile Thr Ala Asp Thr Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Phe Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Leu His Tyr Phe Gly Asn Asn Phe Phe Phe Asp Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120     


<210>  156
<211>  121
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  144D464A HV7b

<400>  156

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Phe Thr Ile Lys Asp Thr 
            20                  25                  30          


Tyr Ile His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Arg Ile Asp Pro Ala Ile Gly Thr Thr Arg Tyr Asp Pro Lys Phe 
    50                  55                  60                  


Gln Gly Lys Ala Thr Ile Thr Thr Asp Thr Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Leu His Tyr Phe Gly Asn Asn Phe Phe Phe Asp Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120     


<210>  157
<211>  121
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  144D464A HV7c

<400>  157

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Phe Thr Ile Lys Asp Thr 
            20                  25                  30          


Tyr Ile His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Arg Ile Asp Pro Ala Ile Gly Thr Thr Arg Tyr Asp Pro Lys Phe 
    50                  55                  60                  


Gln Gly Arg Ala Thr Ile Thr Thr Asp Thr Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Leu Glu Phe Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Leu His Tyr Phe Gly Asn Asn Phe Phe Phe Asp Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120     


<210>  158
<211>  121
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  144D464A HV8d

<400>  158

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Ile Lys Asp Thr 
            20                  25                  30          


Tyr Ile His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Arg Ile Asp Pro Ala Ile Gly Thr Thr Arg Tyr Asp Pro Lys Phe 
    50                  55                  60                  


Gln Gly Lys Ala Thr Ile Thr Thr Asp Thr Ser Thr Asp Thr Ala Tyr 
65                  70                  75                  80  


Leu Glu Phe Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Leu His Tyr Phe Gly Asn Asn Phe Phe Phe Asp Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120     


<210>  159
<211>  121
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  144D464A HV8e

<400>  159

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Ile Lys Asp Thr 
            20                  25                  30          


Tyr Ile His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Arg Ile Asp Pro Ala Ile Gly Thr Thr Arg Tyr Asp Pro Lys Phe 
    50                  55                  60                  


Gln Gly Arg Ala Thr Ile Thr Ala Asp Thr Ser Thr Ser Thr Val Tyr 
65                  70                  75                  80  


Leu Glu Phe Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Leu His Tyr Phe Gly Asn Asn Phe Phe Phe Asp Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120     


<210>  160
<211>  121
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  144D464A HV10a

<400>  160

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Phe Thr Ile Lys Asp Thr 
            20                  25                  30          


Tyr Ile His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Arg Ile Asp Pro Ala Ile Gly Thr Thr Arg Tyr Asp Pro Lys Phe 
    50                  55                  60                  


Gln Gly Arg Ala Thr Ile Thr Thr Asp Thr Ser Thr Asp Thr Ala Tyr 
65                  70                  75                  80  


Leu Glu Phe Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Leu His Tyr Phe Gly Asn Asn Phe Phe Phe Asp Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120     


<210>  161
<211>  121
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  144D464A HV10b

<400>  161

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Phe Asn Ile Lys Asp Thr 
            20                  25                  30          


Tyr Ile His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Arg Ile Asp Pro Ala Ile Gly Thr Thr Arg Tyr Asp Pro Lys Phe 
    50                  55                  60                  


Gln Gly Arg Ala Thr Ile Thr Thr Asp Thr Ser Thr Ser Thr Val Tyr 
65                  70                  75                  80  


Leu Glu Phe Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Leu His Tyr Phe Gly Asn Asn Phe Phe Phe Asp Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120     


<210>  162
<211>  121
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  144D464A HV12

<400>  162

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Leu Ser Cys Lys Ala Ser Gly Phe Asn Ile Lys Asp Thr 
            20                  25                  30          


Tyr Ile His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Arg Ile Asp Pro Ala Ile Gly Thr Thr Arg Tyr Asp Pro Lys Phe 
    50                  55                  60                  


Gln Gly Arg Ala Thr Ile Thr Thr Asp Thr Ser Thr Ser Thr Val Tyr 
65                  70                  75                  80  


Leu Glu Phe Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Leu His Tyr Phe Gly Asn Asn Phe Phe Phe Asp Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Leu Leu Thr Val Ser Ser 
        115                 120     


<210>  163
<211>  121
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  144D464A HV17

<400>  163

Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Leu Ser Cys Lys Ala Ser Gly Phe Asn Ile Lys Asp Thr 
            20                  25                  30          


Tyr Ile His Trp Val Lys Gln Ala Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Arg Ile Asp Pro Ala Ile Gly Thr Thr Arg Tyr Asp Pro Lys Phe 
    50                  55                  60                  


Gln Gly Lys Ala Thr Ile Thr Thr Asp Thr Ser Thr Asp Thr Val Tyr 
65                  70                  75                  80  


Leu Glu Phe Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Leu His Tyr Phe Gly Asn Asn Phe Phe Phe Asp Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Leu Leu Thr Val Ser Ser 
        115                 120     


<210>  164
<211>  109
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  144L249B LV0

<400>  164

Gln Ala Val Val Thr Gln Glu Pro Ser Leu Thr Val Ser Pro Gly Gly 
1               5                   10                  15      


Thr Val Thr Leu Thr Cys Arg Ser Ser Thr Gly Ala Val Thr Thr Ser 
            20                  25                  30          


Asn Tyr Ala Asn Trp Phe Gln Gln Lys Pro Gly Gln Ala Pro Arg Thr 
        35                  40                  45              


Leu Ile Ser Gly Thr Asn Asp Arg Ala Pro Trp Thr Pro Ala Arg Phe 
    50                  55                  60                  


Ser Gly Ser Leu Leu Gly Gly Lys Ala Ala Leu Thr Leu Ser Gly Ala 
65                  70                  75                  80  


Gln Pro Glu Asp Glu Ala Asp Tyr Phe Cys Ala Leu Trp Tyr Ser Asn 
                85                  90                  95      


His Leu Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105                 


<210>  165
<211>  121
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  144L249B HV0

<400>  165

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asp Thr 
            20                  25                  30          


Tyr Ile Tyr Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Arg Ile Asp Pro Ala Ile Gly Thr Thr Arg Tyr Asp Pro Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Ile Thr Ala Asp Thr Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Tyr Asp Tyr Ser Gly Ser Ser Phe Tyr Phe Asp Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120     


<210>  166
<211>  109
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  144L249B LV7a

<400>  166

Gln Ala Val Val Thr Gln Glu Pro Ser Leu Thr Val Ser Pro Gly Gly 
1               5                   10                  15      


Thr Val Thr Leu Thr Cys Arg Ser Ser Thr Gly Ala Val Thr Thr Ser 
            20                  25                  30          


Asn Tyr Ala Asn Trp Val Gln Gln Lys Pro Gly Gln Ala Phe Thr Gly 
        35                  40                  45              


Leu Ile Gly Gly Thr Asn Asp Arg Ala Pro Gly Val Pro Ala Arg Phe 
    50                  55                  60                  


Ser Gly Ser Leu Leu Gly Gly Lys Ala Ala Leu Thr Ile Ser Gly Ala 
65                  70                  75                  80  


Gln Pro Glu Asp Glu Ala Asp Tyr Phe Cys Ala Leu Trp Tyr Ser Asn 
                85                  90                  95      


His Leu Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105                 


<210>  167
<211>  109
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  144L249B LV9

<400>  167

Gln Ala Val Val Thr Gln Glu Pro Ser Leu Thr Val Ser Pro Gly Gly 
1               5                   10                  15      


Thr Val Thr Leu Thr Cys Arg Ser Ser Thr Gly Ala Val Thr Thr Ser 
            20                  25                  30          


Asn Tyr Ala Asn Trp Val Gln Glu Lys Pro Gly Gln Leu Phe Thr Gly 
        35                  40                  45              


Leu Ile Gly Gly Thr Asn Asp Arg Ala Pro Gly Val Pro Ala Arg Phe 
    50                  55                  60                  


Ser Gly Ser Leu Leu Gly Gly Lys Ala Ala Leu Thr Leu Ser Gly Ala 
65                  70                  75                  80  


Gln Pro Glu Asp Glu Ala Asp Tyr Phe Cys Ala Leu Trp Tyr Ser Asn 
                85                  90                  95      


His Leu Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105                 


<210>  168
<211>  109
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  144L249B LV10

<400>  168

Gln Ala Val Val Thr Gln Glu Pro Ser Leu Thr Val Ser Pro Gly Gly 
1               5                   10                  15      


Thr Val Thr Leu Thr Cys Arg Ser Ser Thr Gly Ala Val Thr Thr Ser 
            20                  25                  30          


Asn Tyr Ala Asn Trp Val Gln Glu Lys Pro Gly Gln Leu Phe Thr Gly 
        35                  40                  45              


Leu Ile Gly Gly Thr Asn Asp Arg Ala Pro Gly Val Pro Ala Arg Phe 
    50                  55                  60                  


Ser Gly Ser Leu Leu Gly Gly Lys Ala Ala Leu Thr Leu Ser Gly Ala 
65                  70                  75                  80  


Gln Pro Glu Asp Glu Ala Ile Tyr Phe Cys Ala Leu Trp Tyr Ser Asn 
                85                  90                  95      


His Leu Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105                 


<210>  169
<211>  109
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  144L249B LV11

<400>  169

Gln Ala Val Val Thr Gln Glu Pro Ser Leu Thr Val Ser Pro Gly Gly 
1               5                   10                  15      


Thr Val Thr Leu Thr Cys Arg Ser Ser Thr Gly Ala Val Thr Thr Ser 
            20                  25                  30          


Asn Tyr Ala Asn Trp Val Gln Glu Lys Pro Gly Gln Leu Phe Thr Gly 
        35                  40                  45              


Leu Ile Gly Gly Thr Asn Asp Arg Ala Pro Gly Val Pro Ala Arg Phe 
    50                  55                  60                  


Ser Gly Ser Leu Leu Gly Gly Lys Ala Ala Leu Thr Ile Ser Gly Ala 
65                  70                  75                  80  


Gln Pro Glu Asp Glu Ala Ile Tyr Phe Cys Ala Leu Trp Tyr Ser Asn 
                85                  90                  95      


His Leu Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105                 


<210>  170
<211>  109
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  144L249B LV13

<400>  170

Gln Ala Val Val Thr Gln Glu Ser Ser Leu Thr Thr Ser Pro Gly Gly 
1               5                   10                  15      


Thr Val Thr Leu Thr Cys Arg Ser Ser Thr Gly Ala Val Thr Thr Ser 
            20                  25                  30          


Asn Tyr Ala Asn Trp Val Gln Glu Lys Pro Gly Gln Leu Phe Thr Gly 
        35                  40                  45              


Leu Ile Gly Gly Thr Asn Asp Arg Ala Pro Gly Val Pro Ala Arg Phe 
    50                  55                  60                  


Ser Gly Ser Leu Leu Gly Gly Lys Ala Ala Leu Thr Ile Ser Gly Ala 
65                  70                  75                  80  


Gln Pro Glu Asp Glu Ala Ile Tyr Phe Cys Ala Leu Trp Tyr Ser Asn 
                85                  90                  95      


His Leu Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105                 


<210>  171
<211>  121
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  144L249B HV9a

<400>  171

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Phe Asn Ile Lys Asp Thr 
            20                  25                  30          


Tyr Ile Tyr Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Arg Ile Asp Pro Ala Ile Gly Thr Thr Arg Tyr Asp Pro Lys Phe 
    50                  55                  60                  


Gln Gly Lys Ala Thr Ile Thr Thr Asp Thr Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Leu Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Tyr Asp Tyr Ser Gly Ser Ser Phe Tyr Phe Asp Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120     


<210>  172
<211>  121
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  144L249B HV9b

<400>  172

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Phe Asn Ile Lys Asp Thr 
            20                  25                  30          


Tyr Ile Tyr Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Arg Ile Asp Pro Ala Ile Gly Thr Thr Arg Tyr Asp Pro Lys Phe 
    50                  55                  60                  


Gln Gly Lys Ala Thr Ile Thr Ala Asp Thr Ser Thr Asn Thr Ala Tyr 
65                  70                  75                  80  


Leu Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Tyr Asp Tyr Ser Gly Ser Ser Phe Tyr Phe Asp Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120     


<210>  173
<211>  121
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  144L249B HV10a

<400>  173

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Phe Asn Ile Lys Asp Thr 
            20                  25                  30          


Tyr Ile Tyr Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Arg Ile Asp Pro Ala Ile Gly Thr Thr Arg Tyr Asp Pro Lys Phe 
    50                  55                  60                  


Gln Gly Lys Ala Thr Ile Thr Thr Asp Thr Ser Thr Asn Thr Ala Tyr 
65                  70                  75                  80  


Leu Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Tyr Asp Tyr Ser Gly Ser Ser Phe Tyr Phe Asp Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120     


<210>  174
<211>  121
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  144L249B HV10b

<400>  174

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Phe Asn Ile Lys Asp Thr 
            20                  25                  30          


Tyr Ile Tyr Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Arg Ile Asp Pro Ala Ile Gly Thr Thr Arg Tyr Asp Pro Lys Phe 
    50                  55                  60                  


Gln Gly Lys Ala Thr Leu Thr Thr Asp Thr Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Leu Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Tyr Asp Tyr Ser Gly Ser Ser Phe Tyr Phe Asp Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120     


<210>  175
<211>  121
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  144L249B HV10c

<400>  175

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Phe Asn Ile Lys Asp Thr 
            20                  25                  30          


Tyr Ile Tyr Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Arg Ile Asp Pro Ala Ile Gly Thr Thr Arg Tyr Asp Pro Lys Phe 
    50                  55                  60                  


Gln Gly Lys Ala Thr Leu Thr Ala Asp Thr Ser Thr Asn Thr Ala Tyr 
65                  70                  75                  80  


Leu Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Tyr Asp Tyr Ser Gly Ser Ser Phe Tyr Phe Asp Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120     


<210>  176
<211>  121
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  144L249B HV11

<400>  176

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Phe Asn Ile Lys Asp Thr 
            20                  25                  30          


Tyr Ile Tyr Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Arg Ile Asp Pro Ala Ile Gly Thr Thr Arg Tyr Asp Pro Lys Phe 
    50                  55                  60                  


Gln Gly Lys Ala Thr Leu Thr Thr Asp Thr Ser Thr Asn Thr Ala Tyr 
65                  70                  75                  80  


Leu Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Tyr Asp Tyr Ser Gly Ser Ser Phe Tyr Phe Asp Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120     


<210>  177
<211>  121
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  144L249B HV15

<400>  177

Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Leu Ser Cys Lys Ala Ser Gly Phe Asn Ile Lys Asp Thr 
            20                  25                  30          


Tyr Ile Tyr Trp Val Lys Gln Ala Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Arg Ile Asp Pro Ala Ile Gly Thr Thr Arg Tyr Asp Pro Lys Phe 
    50                  55                  60                  


Gln Gly Lys Ala Thr Leu Thr Ala Asp Thr Ser Thr Asn Thr Ala Tyr 
65                  70                  75                  80  


Leu Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Tyr Asp Tyr Ser Gly Ser Ser Phe Tyr Phe Asp Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Leu Leu Thr Val Ser Ser 
        115                 120     


