               SEQUENCE LISTING

<110> ORTA DOĞU TEKNİK ÜNİVERSİTESİ

<120> MODIFIED AOX1 PROMOTER VARIANTS

<130> P19-0921

<140> PCT/TR2019/050783
<141> 2019-09-23

<150> TR2018/13790
<151> 2018-09-24

<160> 5

<170> BiSSAP 1.3.6

<210> 1
<211> 940
<212> DNA
<213> Pichia pastoris


<220> 
<221> promoter
<222> 1..940
<223> /note="AOX1 wild type promoter"

<400> 1
agatctaaca tccaaagacg aaaggttgaa tgaaaccttt ttgccatccg acatccacag      60

gtccattctc acacataagt gccaaacgca acaggagggg atacactagc agcagaccgt     120

tgcaaacgca ggacctccac tcctcttctc ctcaacaccc acttttgcca tcgaaaaacc     180

agcccagtta ttgggcttga ttggagctcg ctcattccaa ttccttctat taggctacta     240

acaccatgac tttattagcc tgtctatcct ggcccccctg gcgaggttca tgtttgttta     300

tttccgaatg caacaagctc cgcattacac ccgaacatca ctccagatga gggctttctg     360

agtgtggggt caaatagttt catgttcccc aaatggccca aaactgacag tttaaacgct     420

gtcttggaac ctaatatgac aaaagcgtga tctcatccaa gatgaactaa gtttggttcg     480

ttgaaatgct aacggccagt tggtcaaaaa gaaacttcca aaagtcggca taccgtttgt     540

cttgtttggt attgattgac gaatgctcaa aaataatctc attaatgctt agcgcagtct     600

ctctatcgct tctgaacccc ggtgcacctg tgccgaaacg caaatgggga aacacccgct     660

ttttggatga ttatgcattg tctccacatt gtatgcttcc aagattctgg tgggaatact     720

gctgatagcc taacgttcat gatcaaaatt taactgttct aacccctact tgacagcaat     780

atataaacag aaggaagctg ccctgtctta aacctttttt tttatcatca ttattagctt     840

actttcataa ttgcgactgg ttccaattga caagcttttg attttaacga cttttaacga     900

caacttgaga agatcaaaaa acaactaatt attcgaaacg                           940


<210> 2
<211> 940
<212> DNA
<213> Artificial Sequence


<220> 
<223> Modified AOX1 promoter variant

<400> 2
agatctaaca tccaaagacg aaaggttgaa tgaaaccttt ttgccatccg acatccacag      60

gtccattctc acacataagt gccaaacgca acaattccgt tcgtccgatt agcagaccgt     120

tgcaaacgca ggacctccac accccaatat tatttggggt acttttgcca tcgaaaaacc     180

agcccagtta ttgggcttga ttggagctcg ctcattccaa ttccttctat taggctacta     240

acaccatgac tttattagcc tgtctatcct ggcccccctg gcgaggttca tgtttgttta     300

tttccgaatg ccctctcgtc cgggcttttt ccgaacatca ctccagatga gggcgacccc     360

acattttttt tttgacccca catgttcccc aaatggccca aaactgacag tttaaacgct     420

gtcttggaac ctaatatgac aaaagcgtga tctcatccaa gatgaactaa gtttggttcg     480

ttgaaatgct aacggccagt gcctattgta gacgtcaacc caagtcggca taccgtttgt     540

cttgtttggt attgattgac gaatgctcaa aaataatctc attaatgctt agcgcagtct     600

ctctatcgct tctgaacccc ggtgcacctg tgccgaaaca tattccgttc gtccgaatct     660

ttttggatga ttaaccccaa tacattttgg ggttgcttcc aagattctgg tgggaatact     720

gctgatagcc taacgttcat gatcaaaatt taactgttct aacccctact tgacagcaat     780

atataaacag aaggaagctg ccctgtctta aacctttttt tttatcatca ttattagctt     840

actttcataa ttgcgactgg ttccaattga caagcttttg attttaacga cttttaacga     900

caacttgaga agatcaaaaa acaactaatt attcgaaacg                           940


<210> 3
<211> 940
<212> DNA
<213> Artificial Sequence


<220> 
<223> Modified AOX1 promoter variant

<400> 3
agatctaaca tccaaagacg aaaggttgaa tgaaaccttt ttgccatccg acatccacag      60

gtccattctc acacataagt gccaaacgca acaggagggg atacactagc agcagaccgt     120

tgcaaacgca ggacctccac tcctcttctc ctcaacaccc acttttgcca tcgaaaaacc     180

agcccagtta ttgggcttga ttggagctcg ctcattccaa ttccttctat taggctacta     240

acaccatgac tttattagcc tgtctatcct ggcccccctg gcgaggttca tgtttgttta     300

tttccgaatg ccctctcgtc cgggcttttt ccgaacatca ctccagatga gggctttctg     360

agtgtggggt caaatagttt catgttcccc aaatggccca aaactgacag tttaaacgct     420

gtcttggaac ctaatatgac aaaagcgtga tctcatccaa gatgaactaa gtttggttcg     480

ttgaaatgct aacggccagt tggtcaaaaa gaaacttcca aaagtcggca taccgtttgt     540

cttgtttggt attgattgac gaatgctcaa aaataatctc attaatgctt agcgcagtct     600

ctctatcgct tctgaacccc ggtgcacctg tgccgaaacg caaatgggga aacacccgct     660

ttttggatga ttatgcattg tctccacatt gtatgcttcc aagattctgg tgggaatact     720

gctgatagcc taacgttcat gatcaaaatt taactgttct aacccctact tgacagcaat     780

atataaacag aaggaagctg ccctgtctta aacctttttt tttatcatca ttattagctt     840

actttcataa ttgcgactgg ttccaattga caagcttttg attttaacga cttttaacga     900

caacttgaga agatcaaaaa acaactaatt attcgaaacg                           940


<210> 4
<211> 940
<212> DNA
<213> Artificial Sequence


<220> 
<223> Modified AOX1 promoter variant

<400> 4
agatctaaca tccaaagacg aaaggttgaa tgaaaccttt ttgccatccg acatccacag      60

gtccattctc acacataagt gccaaacgca acaggagggg atacactagc agcagaccgt     120

tgcaaacgca ggacctccac tcctcttctc ctcaacaccc acttttgcca tcgaaaaacc     180

agcccagtta ttgggcttga ttggagctcg ctcattccaa ttccttctat taggctacta     240

acaccatgac tttattagcc tgtctatcct ggcccccctg gcgaggttca tgtttgttta     300

tttccgaatg caacaagctc cgcattacac ccgaacatca ctccagatga gggctttctg     360

agtgtggggt caaatagttt catgttcccc aaatggccca aaactgacag tttaaacgct     420

gtcttggaac ctaatatgac aaaagcgtga tctcatccaa gatgaactaa gtttggttcg     480

ttgaaatgct aacggccagt tggtcaaaaa gaaacttcca aaagtcggca taccgtttgt     540

cttgtttggt attgattgac gaatgctcaa aaataatctc attaatgctt agcgcagtct     600

ctctatcgct tctgaacccc ggtgcacctg tgccgaaaca tattccgttc gtccgaatct     660

ttttggatga ttatgcattg tctccacatt gtatgcttcc aagattctgg tgggaatact     720

gctgatagcc taacgttcat gatcaaaatt taactgttct aacccctact tgacagcaat     780

atataaacag aaggaagctg ccctgtctta aacctttttt tttatcatca ttattagctt     840

actttcataa ttgcgactgg ttccaattga caagcttttg attttaacga cttttaacga     900

caacttgaga agatcaaaaa acaactaatt attcgaaacg                           940


<210> 5
<211> 940
<212> DNA
<213> Artificial Sequence


<220> 
<223> Modified AOX1 promoter variant

<400> 5
agatctaaca tccaaagacg aaaggttgaa tgaaaccttt ttgccatccg acatccacag      60

gtccattctc acacataagt gccaaacgca acaggagggg atacactagc agcagaccgt     120

tgcaaacgca ggacctccac tcctcttctc ctcaacaccc acttttgcca tcgaaaaacc     180

agcccagtta ttgggcttga ttggagctcg ctcattccaa ttccttctat taggctacta     240

acaccatgac tttattagcc tgtctatcct ggcccccctg gcgaggttca tgtttgttta     300

tttccgaatg caacaagctc cgcattacac ccgaacatca ctccagatga gggctttctg     360

agtgtggggt caaatagttt catgttcccc aaatggccca aaactgacag tttaaacgct     420

gtcttggaac ctaatatgac aaaagcgtga tctcatccaa gatgaactaa gtttggttcg     480

ttgaaatgct aacggccagt gcctattgta gacgtcaacc caagtcggca taccgtttgt     540

cttgtttggt attgattgac gaatgctcaa aaataatctc attaatgctt agcgcagtct     600

ctctatcgct tctgaacccc ggtgcacctg tgccgaaacg caaatgggga aacacccgct     660

ttttggatga ttatgcattg tctccacatt gtatgcttcc aagattctgg tgggaatact     720

gctgatagcc taacgttcat gatcaaaatt taactgttct aacccctact tgacagcaat     780

atataaacag aaggaagctg ccctgtctta aacctttttt tttatcatca ttattagctt     840

actttcataa ttgcgactgg ttccaattga caagcttttg attttaacga cttttaacga     900

caacttgaga agatcaaaaa acaactaatt attcgaaacg                           940


