                         SEQUENCE LISTING

<110>  Merck Sharp & Dohme Corp.
       Du, Zhimei
       Jiang, Bo
       Tang, Xiaoyan
 
<120>  EXPRESSION VECTORS FOR EUKARYOTIC EXPRESSION SYSTEMS

<130>  24617-WO-PCT

<150>  62/735,417
<151>  2018-09-24

<160>  29    

<170>  PatentIn version 3.5

<210>  1
<211>  569
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  IRES-1

<400>  1
cccctaacgt tactggccga agccgcttgg aataaggccg gtgtgcgttt gtctatatgt       60

tattttccac catattgccg tcttttggca atgtgagggc ccggaaacct ggccctgtct      120

tcttgacgag cattcctagg ggtctttccc ctctcgccaa aggaatgcaa ggtctgttga      180

atgtcgtgaa ggaagcagtt cctctggaag cttcttgaag acaaacaacg tctgtagcga      240

ccctttgcag gcagcggaac cccccacctg gcgacaggtg cctctgcggc caaaagccac      300

gtgtataaga tacacctgca aaggcggcac aaccccagtg ccacgttgtg agttggatag      360

ttgtggaaag agtcaaatgg ctctcctcaa gcgtattcaa caaggggctg aaggatgccc      420

agaaggtacc ccattgtatg ggatctgatc tggggcctcg gtgcacatgc tttacatgtg      480

tttagtcgag gttaaaaaac gtctaggccc cccgaaccac ggggacgtgg ttttcctttg      540

aaaaacacga tgataatatg gccacaacc                                        569


<210>  2
<211>  556
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  IRES-2

<400>  2
cccctaacgt tactggccga agccgcttgg aataaggccg gtgtgcgttt gtctatatgt       60

tattttccac catattgccg tcttttggca atgtgagggc ccggaaacct ggccctgtct      120

tcttgacgag cattcctagg ggtctttccc ctctcgccaa aggaatgcaa ggtctgttga      180

atgtcgtgaa ggaagcagtt cctctggaag cttcttgaag acaaacaacg tctgtagcga      240

ccctttgcag gcagcggaac cccccacctg gcgacaggtg cctctgcggc caaaagccac      300

gtgtataaga tacacctgca aaggcggcac aaccccagtg ccacgttgtg agttggatag      360

ttgtggaaag agtcaaatgg ctctcctcaa gcgtattcaa caaggggctg aaggatgccc      420

agaaggtacc ccattgtatg ggatctgatc tggggcctcg gtgcacatgc tttacatgtg      480

tttagtcgag gttaaaaaac gtctaggccc cccgaaccac ggggacgtgg ttttcctttg      540

aaaaacacga tgataa                                                      556


<210>  3
<211>  549
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  IRES-3

<400>  3
cccctaacgt tactggccga agccgcttgg aataaggccg gtgtgcgttt gtctatatgt       60

tattttccac catattgccg tcttttggca atgtgagggc ccggaaacct ggccctgtct      120

tcttgacgag cattcctagg ggtctttccc ctctcgccaa aggaatgcaa ggtctgttga      180

atgtcgtgaa ggaagcagtt cctctggaag cttcttgaag acaaacaacg tctgtagcga      240

ccctttgcag gcagcggaac cccccacctg gcgacaggtg cctctgcggc caaaagccac      300

gtgtataaga tacacctgca aaggcggcac aaccccagtg ccacgttgtg agttggatag      360

ttgtggaaag agtcaaatgg ctctcctcaa gcgtattcaa caaggggctg aaggatgccc      420

agaaggtacc ccattgtatg ggatctgatc tggggcctcg gtgcacatgc tttacatgtg      480

tttagtcgag gttaaaaaac gtctaggccc cccgaaccac ggggacgtgg ttttcctttg      540

aaaaacacg                                                              549


<210>  4
<211>  6215
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  pCLD116

<400>  4
ccaatgatct taagttaacc ctagaaagat aatcatattg tgacgtacgt taaagataat       60

catgcgtaaa attgacgcat gtgttttatc ggtctgtata tcgaggttta tttattaatt      120

tgaatagata ttaagtttta ttatatttac acttacatac taataataaa ttcaacaaac      180

aatttattta tgtttattta tttattaaaa aaaaacaaaa actcaaaatt tcttctataa      240

agtaacaaaa cttttatcga atttgcagcc cgggactagc tagagggaca gccccccccc      300

aaagccccca gggatgtaat tacgtccctc ccccgctagg gggcagcagc gagccgcccg      360

gggctccgct ccggtccggc gctccccccg catccccgag ccggcagcgt gcggggacag      420

cccgggcacg gggaaggtgg cacgggatcg ctttcctctg aacgcttctc gctgctcttt      480

gagcctgcag acacctgggg ggatacgggg aaaacttaag atccgaccgg tgctgtggaa      540

tgtgtgtcag ttagggtgtg gaaagtcccc aggctcccca gcaggcagaa gtatgcaaag      600

catgcatctc aattagtcag caaccaggtg tggaaagtcc ccaggctccc cagcaggcag      660

aagtatgcaa agcatgcatc tcaattagtc agcaaccata gtcccgcccc taactccgcc      720

catcccgccc ctaactccgc ccagttccgc ccattctccg ctccatcgtt cagattttac      780

cacatttgta gaggttttac ttgctttaaa aaacctccca cacctccccc tgaacctgaa      840

acataaaatg aatgcaattg ttgttgttaa cttgtttatt gcagcttata atggttacaa      900

ataaagcaat agcatcacaa atttcacaaa taaagcattt ttttcactgc attctagttg      960

tggtttgtcc aaactcatca atgtatctta tcatgtctgc tcgaagcggc cggccgcccc     1020

gactctagat tagtttttgt attggaaggg ctcgtcgcca gtctcattga gaaggcatgt     1080

gcggacgatg gcttctgtca ctgcaaaggg gtcacaattg gcagaggggc ggcggtcttc     1140

aaagtaacct ttcttctcct ggccgacagt ccggggaatg cggatgctgg cactgcgatt     1200

ggcgacacca gcagaaaagt cgttgatgtt ggacgtttcg tggaacccag tcagacgacg     1260

ggcattgtcc aggcccccct tgggatcgta ggctcgaatg tggtaccggt gccgcttgct     1320

tagtttctcg atggcctcct cgatgtgctt cagaccattc tcctcccgca tggccttggt     1380

gctaaagttg gtatggcagc ctgcaccatt ccagttccca ggaatgggct tggggtcaaa     1440

ggttgctatt accccaaagt cttcacatac tcgatgcaag atgaaacggg ccacccagag     1500

atgatctccc atgcggattc cttcacaggg tcctatttgg aactcccact gggcaggcat     1560

gacctcagca tttgttcctg taatcttgac cccagcatac aagcaggcgc ggtagtgagc     1620

ctccacgata tccctgccat aggctttgtc tgcgcccaca ccacagtaat acggaccttg     1680

gggcccagga aagccattgg aaggccaacc aaaagggtgc ccatctgttc ccatcagagt     1740

atactcctgt tccattccaa accaggggtg ctggttgctc accatgtcca ttatccgttt     1800

acacgagtgc cttaaattgg tctctgcagg cttccggttg tacttgaaaa cttcacagaa     1860

caccagcttg ttgggatctc tgcggaaggg gtcccgaaac atggcaacag ggctgagata     1920

catgtcactg ttggagccct cagactgaaa ggtactagag ccatcaaaat tccactcagg     1980

taactcttct acacacttgg gctcacagtc cagggtgcgg gttttgcagc gcagtccttc     2040

tccagtacca tcaacccaga tatacatggc ttggactttc tcaccctggg gcaggcacaa     2100

gtacatttgc ttgatgtttt tgttcaagtg ggaacttgct gaggtggcca tggtggcggc     2160

tttgcaaaag cctaggcctc caaaaaagcc tcctcactac ttctggaata gctcagaggc     2220

cgaggcggcc tcggcctctg cataaataaa aaaaattagt cagcgatggg gcggagaatg     2280

ggcggaactg ggcggagtta ggggcgggat gggcggagtt aggggcggga ctatggttgc     2340

tgactaattg agatgcaatc actgacacac attccacagc tgcctcgcgc gtttcggtga     2400

tgacggtgaa aacctctgac acatgcagct cccggagacg gtcacagctt gtctgtaagc     2460

ggatgccggg agcagacaag cccgtcaggg cgcgtcagcg ggtgttggcg ggtgtcgggg     2520

cgcagccatg acccagtcac gtagcgatag cggagtgtat actggcttaa ctatgcggca     2580

tcagagcaga ttgtactgag cctcgagcga tgtacgggcc agatatacgc gttgacattg     2640

attattgact agttattaat agtaatcaat tacggggtca ttagttcata gcccatatat     2700

ggagttccgc gttacataac ttacggtaaa tggcccgcct ggctgaccgc ccaacgaccc     2760

ccgcccattg acgtcaataa tgacgtatgt tcccatagta acgccaatag ggactttcca     2820

ttgacgtcaa tgggtggact atttacggta aactgcccac ttggcagtac atcaagtgta     2880

tcatatgcca agtacgcccc ctattgacgt caatgacggt aaatggcccg cctggcatta     2940

tgcccagtac atgaccttat gggactttcc tacttggcag tacatctacg tattagtcat     3000

cgctattacc atggtgatgc ggttttggca gtacatcaat gggcgtggat agcggtttga     3060

ctcacgggga tttccaagtc tccaccccat tgacgtcaat gggagtttgt tttggcacca     3120

aaatcaacgg gactttccaa aatgtcgtaa caactccgcc ccattgacgc aaatgggcgg     3180

taggcgtgta cggtgggagg tctatataag cagagctctc tggctaacta gagaacccac     3240

tgcttactgg cttatcgaaa ttaatacgac tcactatagc aattgcacgt gtggccacag     3300

gtaagtttaa agctcaggtc gagaccgggc ctttgtccgg cgctcccttg gagcctacct     3360

agactcagcc ggctctccac gctttgcctg accctgcttg ctcaactcta cgtctttgtt     3420

tcgttttctg ttcctttctc tccacaggcg gatccgaatt ctgaagatct agatccccct     3480

cgctttcttg ctgtccaatt tctattaaag gttcctttgt tccctaagtc caactactaa     3540

actgggggat attatgaagg gccttgagca tctggattct gcctaataaa aaacatttat     3600

tttcattgca atgatgtatt taaattattt ctgaatattt tactaaaaag ggaatgtggg     3660

aggtcagtgc atttaaaaca taaagaaatg aagaggggga tcttcgcgaa tccatcgatg     3720

agggacagcc cccccccaaa gcccccaggg atgtaattac gtccctcccc cgctaggggg     3780

cagcagcgag ccgcccgggg ctccgctccg gtccggcgct ccccccgcat ccccgagccg     3840

gcagcgtgcg gggacagccc gggcacgggg aaggtggcac gggatcgctt tcctctgaac     3900

gcttctcgct gctctttgag cctgcagaca cctgggggga tacggggaaa atagacaccg     3960

cggtggagct ccagcttttg ttccctttag tgagggttaa ttagttctta atacgactca     4020

ctatagggcg aattggctac cgggccgccc atcgagggta tcataagctt atatctataa     4080

caagaaaata tatatataat aagttatcac gtaagtagaa catgaaataa caatataatt     4140

atcgtatgag ttaaatctta aaagtcacgt aaaagataat catgcgtcat tttgactcac     4200

gcggtcgtta tagttcaaaa tcagtgacac ttaccgcatt gacaagcacg cctcacggga     4260

gctccaagcg gcgactgaga tgtcctaaat gcacagcgac ggattcgcgc tatttagaaa     4320

gagagagcaa tatttcaaga atgcatgcgt caattttacg cagactatct ttctagggtt     4380

aaatcgatat cggaaagaac atgtgagcaa aaggccagca aaaggccagg aaccgtaaaa     4440

aggccgcgtt gctggcgttt ttccataggc tccgcccccc tgacgagcat cacaaaaatc     4500

gacgctcaag tcagaggtgg cgaaacccga caggactata aagataccag gcgtttcccc     4560

ctggaagctc cctcgtgcgc tctcctgttc cgaccctgcc gcttaccgga tacctgtccg     4620

cctttctccc ttcgggaagc gtggcgcttt ctcatagctc acgctgtagg tatctcagtt     4680

cggtgtaggt cgttcgctcc aagctgggct gtgtgcacga accccccgtt cagcccgacc     4740

gctgcgcctt atccggtaac tatcgtcttg agtccaaccc ggtaagacac gacttatcgc     4800

cactggcagc agccactggt aacaggatta gcagagcgag gtatgtaggc ggtgctacag     4860

agttcttgaa gtggtggcct aactacggct acactagaag aacagtattt ggtatctgcg     4920

ctctgctgaa gccagttacc ttcggaaaaa gagttggtag ctcttgatcc ggcaaacaaa     4980

ccaccgctgg tagcggtggt ttttttgttt gcaagcagca gattacgcgc agaaaaaaag     5040

gatctcaaga agatcctttg atcttttcta cggggtctga cgctcagtgg aacgaaaact     5100

cacgttaagg gattttggtc atgagattat caaaaaggat cttcacctag atccttttaa     5160

attaaaaatg aagttttaaa tcaatctaaa gtatatatga gtaaacttgg tctgacagtt     5220

accaatgctt aatcagtgag gcacctatct cagcgatctg tctatttcgt tcatccatag     5280

ttgcctgact ccccgtcgtg tagataacta cgatacggga gggcttacca tctggcccca     5340

gtgctgcaat gataccgcga gacccacgct caccggctcc agatttatca gcaataaacc     5400

agccagccgg aagggccgag cgcagaagtg gtcctgcaac tttatccgcc tccatccagt     5460

ctattaattg ttgccgggaa gctagagtaa gtagttcgcc agttaatagt ttgcgcaacg     5520

ttgttgccat tgctacaggc atcgtggtgt cacgctcgtc gtttggtatg gcttcattca     5580

gctccggttc ccaacgatca aggcgagtta catgatcccc catgttgtgc aaaaaagcgg     5640

ttagctcctt cggtcctccg atcgttgtca gaagtaagtt ggccgcagtg ttatcactca     5700

tggttatggc agcactgcat aattctctta ctgtcatgcc atccgtaaga tgcttttctg     5760

tgactggtga gtactcaacc aagtcattct gagaatagtg tatgcggcga ccgagttgct     5820

cttgcccggc gtcaatacgg gataataccg cgccacatag cagaacttta aaagtgctca     5880

tcattggaaa acgttcttcg gggcgaaaac tctcaaggat cttaccgctg ttgagatcca     5940

gttcgatgta acccactcgt gcacccaact gatcttcagc atcttttact ttcaccagcg     6000

tttctgggtg agcaaaaaca ggaaggcaaa atgccgcaaa aaagggaata agggcgacac     6060

ggaaatgttg aatactcata ctcttccttt ttcaatatta ttgaagcatt tatcagggtt     6120

attgtctcat gagcggatac atatttgaat gtatttagaa aaataaacaa ataggggttc     6180

cgcgcacatt tccccgaaaa gtgccacctg acgtc                                6215


<210>  5
<211>  9542
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  pCLD21

<400>  5
ccttcccttc taccacaccc taattgtaat ccattttaat ttcctggtca cagtcctgtc       60

tctccttcca ttgtaccttg cccttttcta aagagcgact gcaaagtatg tttgcgtagg      120

tgaggatcta aaactttatg aggtacgaac atcacagaat tactttgtaa tttcagttta      180

ttgtaggctt ggctttttgg ggagggttta cgtcttagac ctcttagtgc ttctttgttt      240

catggtgttc taacttcgaa gcatctctgt agctttaatg gattcctttt ctgaaagctt      300

tgctctcttt cttccccctc ggctttctct taggcaagag ggctaactgt aaagtaaggc      360

ttactgcctt gtgtttccaa atgtgtccga agaggaagtg tcttctgtga atcctgttat      420

gcatgaataa caggaaatag aaagaaattc actttcatta ttataaaagt aatatgttcg      480

tttaaaaaat tctaatgaag agctggagat gcaacccagg ggtagagcac acactcagca      540

tgcaggaggc cctgggtcca atcttggaat ctcctctcag ttaacctgat ctctagctga      600

ttagtagtga gtgcaagccc actttcctct tctgcctcat tgctcagtga taacagctgt      660

taaactttgt cttattctaa aactacctct gtgcaaatgc tagcacaata atatatatca      720

tatgcacatg attttttttt tatcttgaaa agtaagtcag tatagctaca aagttcactt      780

ggcattgtca acatttcaca ggcgtaatat tcctcctcta gtactgtcct cttcattctt      840

tgtgaccaag tttggagaga gtgcacaaat gccagggagg tttgtgggaa ggtttctcat      900

gttctggtaa ggcgagtaag aaaatagtct catgcaggtg aaatgagtgc tatgcagtat      960

atattatacc agagaacagc aaatgaccaa attcacactg aactagttca gtaaaattgg     1020

ctttgtcaaa gctttccttg cttaaaatgt aattccctgt catcctagtt ctggtctgga     1080

ttcttttcct ggagtcttga cttccagatt ccctgtggac ttttgtttga gtttcaagct     1140

tttgaaatat agaaacctat ctaacttaac aaacttggga gagaaaagac tccagaacaa     1200

ctgaaaacag accaggctaa atgaatagac tttattcctc tcttcttacc tgcagttttc     1260

agatatgcag agttggagcg gatcttagag gttgattcat tcatgcctga agaaaacaca     1320

ttttatagac cctgtgccca agttcgtggt ggacatcacc ctttatttac taattgcact     1380

acataacagg cattttagaa gactgctcca gtcagagacc ccgccttaga ggaatctgta     1440

aaccctgaac tcctatcact catgagcact agttatgttt ggaatgccgt attaaaacaa     1500

aagttacatt tctaaactta aaattttcta gcacagagac agtgggagta gctaactttg     1560

atagacattt ttctactaaa agtctttcta agtacataat cttctgtaag ttggaaaaca     1620

gcaaaataga acgtctccta cgtagttaat ctttttgcat aatttgcaca tgtaggagtt     1680

attagtatac gggtaagttt tcactttttc ccccaactgg agtgtcttgt ggctgggttt     1740

gaaaaaggga acgggaggcc gctggagggg attggtaaat gagataaaac accactcatt     1800

caactcagtg actcagcatt taaattttcc ataaaaggat taaaggaaaa ttaaacaaat     1860

tcttaaagcc aagactctgg agaaacttgt tggtgtgctt tagttttcac tgttatgact     1920

catgaattta tgcataaatt agtacattta taaaaacata gcctttttag agttttctgt     1980

ttggctaaag tgccattgtt agcatttgga attacctttt tatgtcttat attttttcca     2040

aataaaaata aatgtttctg ctgtcttact actgaaacta cgttgtgagc actttaaatt     2100

tctcaaagca gtttcgcctg ttatacttgg cgcttagtca tcgtcgtaca caacaggacc     2160

tgattaagaa ggctgtgctg cctctaagcc gggctagatt gtagccacta gcaaccaggc     2220

tgcaataatt tccctttgat gacatcatcc actgtggaag aacccagttg cttcagccag     2280

tcgaactata cagttccaac ctcatcaaat atggcatctc ccttgcctgc tatagcaggg     2340

ggaggaaaaa atgccaccat ctttttaatc tagcaagctt ctcttttctt catctttttt     2400

tttttctttt aaaaaaattc tgatcatgga tgcttcttcc gatccctatt tgccttatga     2460

cgggggagga gacaatatcc ccttgaggga attacataaa agaggtaaga gcatcccctt     2520

gctctgaatc ctctgttggt tgttgtgcat gcggctgggc ggttctgggg acaggctgtc     2580

tgttgtcctc ttgctgcaat gtgctgctta gttgccctgc cttgttgctg tgggagaatg     2640

cgaccttccc agcagggctg gccctccctg attgtttgct ctgtgcagat tagccctgct     2700

tcagatcaca tagggctgca gactccatct tctgtgtgaa aatgctttcg gtttgattgc     2760

agaaataagc tgcctttaca gccagctaaa gtcctggtgg ttggttggca cctgcaaagt     2820

agtatttttg tacctctgga aacttatatt ttctttacac agcaatatca agtgccggta     2880

tgccattctg ttttggctgc tgccaattac catgtagact ttgcaccaca gagtaatagt     2940

aaaagctcct agctgcattt tataacattt aaaaatagca ggaaagaaga attatttttg     3000

atttaacatg tttttgtcat ttaacgtctt aactgattga catactatat tgtctgtctc     3060

gtgggtatct tgtacaactt gataggataa agcaatttag tttttttttt tttttttaaa     3120

tacatccaga atgtaagtcg tcagtagttt tcgaacagat aagtaatggt gttaatcttt     3180

tggcaggctt tgccttggtc tccttaaagc taattaggtg ttacttaatt aaactgctct     3240

tttgctcatt ttcttaaatt atttttttaa aagatagttg gcatttgctg ttctagaaat     3300

aaacttcaag aaacattctt tagccagatg acttcatgta tgagccatgt tagtttgaat     3360

tatttgcttg gtgttataaa ctttatggtt taataccaac ttttattatg tttacaaggt     3420

aaataaggaa aatttcaagt acattttgta tcctgagaac aaatttaagt tccatagaat     3480

ttaggaatta caatgtattc aacagatact tacttgtcat actgtgcctg caaaacaata     3540

attagactct gaacaggtgc aacaattttc tgtagaatta gacaagtctt cttttggcag     3600

gtgttactaa gtaggccatt tcccaaggaa cagggaattt gccaggcttt tgtggtggag     3660

agaatagaat gaataaatgc tgtggggagt aaagagcttg tcagaagatg attagttctg     3720

tggcaccaaa accaagagat cagttttcct gtgagaagta aaggaagcat tgtagaaaaa     3780

tagatgtgtt gaagtctacc ggtggagttc cgcgttacat aacttacggt aaatggcccg     3840

cctggctgac cgcccaacga cccccgccca ttgacgtcaa taatgacgta tgttcccata     3900

gtaacgccaa tagggacttt ccattgacgt caatgggtgg agtatttacg gtaaactgcc     3960

cacttggcag tacatcaagt gtatcatatg ccaagtacgc cccctattga cgtcaatgac     4020

ggtaaatggc ccgcctggca ttatgcccag tacatgacct tatgggactt tcctacttgg     4080

cagtacatct acgtattagt catcgctatt accattgtga tgcggttttg gcagtacatc     4140

aatgggcgtg gatagcggtt tgactcacgg ggatttccaa gtctccaccc cattgacgtc     4200

aatgggagtt tgttttggca ccaaaatcaa cgggactttc caaaatgtcg taacaactcc     4260

gccccattga cgcaaatggg cggtaggcgt gtacggtggg aggtctatat aagcagagct     4320

cgtttagtga accgtcagat ctacctcttc cgcatcgctg tctgcgaggg ccagctgttg     4380

gggtgagtac tccctctcaa aagcgggcat gacttctgcg ctaagattgt cagtttccaa     4440

aaacgaggag gatttgatat tcacctggcc cgcggtgatg cctttgaggg tggccgcgtc     4500

catctggtca gaaaagacaa tctttttgtt gtcaagcttc cttgatgatg tcatacttat     4560

cctgtccctt ttttttccac agctcgcggt tgaggacaaa ctcttcgcgg tctttccagt     4620

actcttggat cggaaacccg tcggcctccg aacggtactc cgccaccgag ggacctgagc     4680

gagtccgcat cgaccggatc ggaaaacctc ggatccgaat tcatagataa ctgatccagt     4740

gcccctaacg ttactggccg aagccgcttg gaataaggcc ggtgtgcgtt tgtctatatg     4800

ttattttcca ccatattgcc gtcttttggc aatgtgaggg cccggaaacc tggccctgtc     4860

ttcttgacga gcattcctag gggtctttcc cctctcgcca aaggaatgca aggtctgttg     4920

aatgtcgtga aggaagcagt tcctctggaa gcttcttgaa gacaaacaac gtctgtagcg     4980

accctttgca ggcagcggaa ccccccacct ggcgacaggt gcctctgcgg ccaaaagcca     5040

cgtgtataag atacacctgc aaaggcggca caaccccagt gccacgttgt gagttggata     5100

gttgtggaaa gagtcaaatg gctctcctca agcgtattca acaaggggct gaaggatgcc     5160

cagaaggtac cccattgtat gggatctgat ctggggcctc ggtgcacatg ctttacatgt     5220

gtttagtcga ggttaaaaaa cgtctaggcc ccccgaacca cggggacgtg gttttccttt     5280

gaaaaacacg atgataatat ggccacaacc atggccacct cagcaagttc ccacttgaac     5340

aaaaacatca agcaaatgta cttgtgcctg ccccagggtg agaaagtcca agccatgtat     5400

atctgggttg atggtactgg agaaggactg cgctgcaaaa cccgcaccct ggactgtgag     5460

cccaagtgtg tagaagagtt acctgagtgg aattttgatg gctctagtac ctttcagtct     5520

gagggctcca acagtgacat gtatctcagc cctgttgcca tgtttcggga ccccttccgc     5580

agagatccca acaagctggt gttctgtgaa gttttcaagt acaaccggaa gcctgcagag     5640

accaatttaa ggcactcgtg taaacggata atggacatgg tgagcaacca gcacccctgg     5700

tttggaatgg aacaggagta tactctgatg ggaacagatg ggcacccttt tggttggcct     5760

tccaatggct ttcctgggcc ccaaggtccg tattactgtg gtgtgggcgc agacaaagcc     5820

tatggcaggg atatcgtgga ggctcactac cgcgcctgct tgtatgctgg ggtcaagatt     5880

acaggaacaa atgctgaggt catgcctgcc cagtgggagt tccaaatagg accctgtgaa     5940

ggaatccgca tgggagatca tctctgggtg gcccgtttca tcttgcatcg agtatgtgaa     6000

gactttgggg taatagcaac ctttgacccc aagcccattc ctgggaactg gaatggtgca     6060

ggctgccata ccaactttag caccaaggcc atgcgggagg agaatggtct gaagcacatc     6120

gaggaggcca tcgagaaact aagcaagcgg caccggtacc acattcgagc ctacgatccc     6180

aaggggggcc tggacaatgc ccgtcgtctg actgggttcc acgaaacgtc caacatcaac     6240

gacttttctg ctggtgtcgc caatcgcagt gccagcatcc gcattccccg gactgtcggc     6300

caggagaaga aaggttactt tgaagaccgc cgcccctctg ccaattgtga cccctttgca     6360

gtgacagaag ccatcgtccg cacatgcctt ctcaatgaga ctggcgacga gcccttccaa     6420

tacaaaaact aatctagatc cccctcgctt tcttgctgtc caatttctat taaaggttcc     6480

tttgttccct aagtccaact actaaactgg gggatattat gaagggcctt gagcatctgg     6540

attctgccta ataaaaaaca tttattttca ttgcaatgat gtatttaaat tatttctgaa     6600

tattttacta aaaagggaat gtgggaggtc agtgcattta aaacataaag aaatgaagag     6660

ggggatcttc gcgacctgca ggtctcccta tagtgagtcg tattaatttc gataagccag     6720

ctgcattaat gaatcggcca acgcgcgggg agaggcggtt tgcgtattgg gcgctcttcc     6780

gcttcctcgc tcactgactc gctgcgctcg gtcgttcggc tgcggcgagc ggtatcagct     6840

cactcaaagg cggtaatacg gttatccaca gaatcagggg ataacgcagg aaagaacatg     6900

tgagcaaaag gccagcaaaa ggccaggaac cgtaaaaagg ccgcgttgct ggcgtttttc     6960

cataggctcc gcccccctga cgagcatcac aaaaatcgac gctcaagtca gaggtggcga     7020

aacccgacag gactataaag ataccaggcg tttccccctg gaagctccct cgtgcgctct     7080

cctgttccga ccctgccgct taccggatac ctgtccgcct ttctcccttc gggaagcgtg     7140

gcgctttctc atagctcacg ctgtaggtat ctcagttcgg tgtaggtcgt tcgctccaag     7200

ctgggctgtg tgcacgaacc ccccgttcag cccgaccgct gcgccttatc cggtaactat     7260

cgtcttgagt ccaacccggt aagacacgac ttatcgccac tggcagcagc cactggtaac     7320

aggattagca gagcgaggta tgtaggcggt gctacagagt tcttgaagtg gtggcctaac     7380

tacggctaca ctagaaggac agtatttggt atctgcgctc tgctgaagcc agttaccttc     7440

ggaaaaagag ttggtagctc ttgatccggc aaacaaacca ccgctggtag cggtggtttt     7500

tttgtttgca agcagcagat tacgcgcaga aaaaaaggat ctcaagaaga tcctttgatc     7560

ttttctacgg ggtctgacgc tcagtggaac gaaaactcac gttaagggat tttggtcatg     7620

agattatcaa aaaggatctt cacctagatc cttttaaatt aaaaatgaag ttttaaatca     7680

atctaaagta tatatgagta aacttggtct gacagttacc aatgcttaat cagtgaggca     7740

cctatctcag cgatctgtct atttcgttca tccatagttg cctgactccc cgtcgtgtag     7800

ataactacga tacgggaggg cttaccatct ggccccagtg ctgcaatgat accgcgagac     7860

ccacgctcac cggctccaga tttatcagca ataaaccagc cagccggaag ggccgagcgc     7920

agaagtggtc ctgcaacttt atccgcctcc atccagtcta ttaattgttg ccgggaagct     7980

agagtaagta gttcgccagt taatagtttg cgcaacgttg ttgccattgc tacaggcatc     8040

gtggtgtcac gctcgtcgtt tggtatggct tcattcagct ccggttccca acgatcaagg     8100

cgagttacat gatcccccat gttgtgcaaa aaagcggtta gctccttcgg tcctccgatc     8160

gttgtcagaa gtaagttggc cgcagtgtta tcactcatgg ttatggcagc actgcataat     8220

tctcttactg tcatgccatc cgtaagatgc ttttctgtga ctggtgagta ctcaaccaag     8280

tcattctgag aatagtgtat gcggcgaccg agttgctctt gcccggcgtc aatacgggat     8340

aataccgcgc cacatagcag aactttaaaa gtgctcatca ttggaaaacg ttcttcgggg     8400

cgaaaactct caaggatctt accgctgttg agatccagtt cgatgtaacc cactcgtgca     8460

cccaactgat cttcagcatc ttttactttc accagcgttt ctgggtgagc aaaaacagga     8520

aggcaaaatg ccgcaaaaaa gggaataagg gcgacacgga aatgttgaat actcatactc     8580

ttcctttttc aatattattg aagcatttat cagggttatt gtctcatgag cggatacata     8640

tttgaatgta tttagaaaaa taaacaaata ggggttccgc gcacatttcc ccgaaaagtg     8700

ccacctgacg tctaagaaac cattattatc atgacattaa cctataaaaa taggcgtatc     8760

acgaggccct ttcgtctcgc gcgtttcggt gatgacggtg aaaacctctg acacatgcag     8820

ctcccggaga cggtcacagc ttgtctgtaa gcggatgccg ggagcagaca agcccgtcag     8880

ggcgcgtcag cgggtgttgg cgggtgtcgg ggctggctta actatgcggc atcagagcag     8940

attgtactga gagtgcacca tatcgacgct ctcccttatg cgactcctgc attaggaagc     9000

agcccagtag taggttgagg ccgttgagca ccgccgccgc aaggaatggt gcatgcaagg     9060

agatggcgcc caacagtccc ccggccacgg ggcctgccac catacccacg ccgaaacaag     9120

cgctcatgag cccgaagtgg cgagcccgat cttccccatc ggtgatgtcg gcgatatagg     9180

cgccagcaac cgcacctgtg gcgccggtga tgccggccac gatgcgtccg gcgtagagga     9240

tctggctagc gatgaccctg ctgattggtt cgctgaccat ttccggggtg cggaacggcg     9300

ttaccagaaa ctcagaaggt tcgtccaacc aaaccgactc tgacggcagt ttacgagaga     9360

gatgataggg tctgcttcag taagccagat gctacacaat taggcttgta catattgtcg     9420

ttagaacgcg gctacaatta atacataacc ttatgtatca tacacatacg atttaggtga     9480

cactatagaa tacacctgca ggacgcgtac tgagagcgct attctgaact tttcttttgt     9540

tc                                                                    9542


<210>  6
<211>  9522
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  pCLD22

<400>  6
ccttcccttc taccacaccc taattgtaat ccattttaat ttcctggtca cagtcctgtc       60

tctccttcca ttgtaccttg cccttttcta aagagcgact gcaaagtatg tttgcgtagg      120

tgaggatcta aaactttatg aggtacgaac atcacagaat tactttgtaa tttcagttta      180

ttgtaggctt ggctttttgg ggagggttta cgtcttagac ctcttagtgc ttctttgttt      240

catggtgttc taacttcgaa gcatctctgt agctttaatg gattcctttt ctgaaagctt      300

tgctctcttt cttccccctc ggctttctct taggcaagag ggctaactgt aaagtaaggc      360

ttactgcctt gtgtttccaa atgtgtccga agaggaagtg tcttctgtga atcctgttat      420

gcatgaataa caggaaatag aaagaaattc actttcatta ttataaaagt aatatgttcg      480

tttaaaaaat tctaatgaag agctggagat gcaacccagg ggtagagcac acactcagca      540

tgcaggaggc cctgggtcca atcttggaat ctcctctcag ttaacctgat ctctagctga      600

ttagtagtga gtgcaagccc actttcctct tctgcctcat tgctcagtga taacagctgt      660

taaactttgt cttattctaa aactacctct gtgcaaatgc tagcacaata atatatatca      720

tatgcacatg attttttttt tatcttgaaa agtaagtcag tatagctaca aagttcactt      780

ggcattgtca acatttcaca ggcgtaatat tcctcctcta gtactgtcct cttcattctt      840

tgtgaccaag tttggagaga gtgcacaaat gccagggagg tttgtgggaa ggtttctcat      900

gttctggtaa ggcgagtaag aaaatagtct catgcaggtg aaatgagtgc tatgcagtat      960

atattatacc agagaacagc aaatgaccaa attcacactg aactagttca gtaaaattgg     1020

ctttgtcaaa gctttccttg cttaaaatgt aattccctgt catcctagtt ctggtctgga     1080

ttcttttcct ggagtcttga cttccagatt ccctgtggac ttttgtttga gtttcaagct     1140

tttgaaatat agaaacctat ctaacttaac aaacttggga gagaaaagac tccagaacaa     1200

ctgaaaacag accaggctaa atgaatagac tttattcctc tcttcttacc tgcagttttc     1260

agatatgcag agttggagcg gatcttagag gttgattcat tcatgcctga agaaaacaca     1320

ttttatagac cctgtgccca agttcgtggt ggacatcacc ctttatttac taattgcact     1380

acataacagg cattttagaa gactgctcca gtcagagacc ccgccttaga ggaatctgta     1440

aaccctgaac tcctatcact catgagcact agttatgttt ggaatgccgt attaaaacaa     1500

aagttacatt tctaaactta aaattttcta gcacagagac agtgggagta gctaactttg     1560

atagacattt ttctactaaa agtctttcta agtacataat cttctgtaag ttggaaaaca     1620

gcaaaataga acgtctccta cgtagttaat ctttttgcat aatttgcaca tgtaggagtt     1680

attagtatac gggtaagttt tcactttttc ccccaactgg agtgtcttgt ggctgggttt     1740

gaaaaaggga acgggaggcc gctggagggg attggtaaat gagataaaac accactcatt     1800

caactcagtg actcagcatt taaattttcc ataaaaggat taaaggaaaa ttaaacaaat     1860

tcttaaagcc aagactctgg agaaacttgt tggtgtgctt tagttttcac tgttatgact     1920

catgaattta tgcataaatt agtacattta taaaaacata gcctttttag agttttctgt     1980

ttggctaaag tgccattgtt agcatttgga attacctttt tatgtcttat attttttcca     2040

aataaaaata aatgtttctg ctgtcttact actgaaacta cgttgtgagc actttaaatt     2100

tctcaaagca gtttcgcctg ttatacttgg cgcttagtca tcgtcgtaca caacaggacc     2160

tgattaagaa ggctgtgctg cctctaagcc gggctagatt gtagccacta gcaaccaggc     2220

tgcaataatt tccctttgat gacatcatcc actgtggaag aacccagttg cttcagccag     2280

tcgaactata cagttccaac ctcatcaaat atggcatctc ccttgcctgc tatagcaggg     2340

ggaggaaaaa atgccaccat ctttttaatc tagcaagctt ctcttttctt catctttttt     2400

tttttctttt aaaaaaattc tgatcatgga tgcttcttcc gatccctatt tgccttatga     2460

cgggggagga gacaatatcc ccttgaggga attacataaa agaggtaaga gcatcccctt     2520

gctctgaatc ctctgttggt tgttgtgcat gcggctgggc ggttctgggg acaggctgtc     2580

tgttgtcctc ttgctgcaat gtgctgctta gttgccctgc cttgttgctg tgggagaatg     2640

cgaccttccc agcagggctg gccctccctg attgtttgct ctgtgcagat tagccctgct     2700

tcagatcaca tagggctgca gactccatct tctgtgtgaa aatgctttcg gtttgattgc     2760

agaaataagc tgcctttaca gccagctaaa gtcctggtgg ttggttggca cctgcaaagt     2820

agtatttttg tacctctgga aacttatatt ttctttacac agcaatatca agtgccggta     2880

tgccattctg ttttggctgc tgccaattac catgtagact ttgcaccaca gagtaatagt     2940

aaaagctcct agctgcattt tataacattt aaaaatagca ggaaagaaga attatttttg     3000

atttaacatg tttttgtcat ttaacgtctt aactgattga catactatat tgtctgtctc     3060

gtgggtatct tgtacaactt gataggataa agcaatttag tttttttttt tttttttaaa     3120

tacatccaga atgtaagtcg tcagtagttt tcgaacagat aagtaatggt gttaatcttt     3180

tggcaggctt tgccttggtc tccttaaagc taattaggtg ttacttaatt aaactgctct     3240

tttgctcatt ttcttaaatt atttttttaa aagatagttg gcatttgctg ttctagaaat     3300

aaacttcaag aaacattctt tagccagatg acttcatgta tgagccatgt tagtttgaat     3360

tatttgcttg gtgttataaa ctttatggtt taataccaac ttttattatg tttacaaggt     3420

aaataaggaa aatttcaagt acattttgta tcctgagaac aaatttaagt tccatagaat     3480

ttaggaatta caatgtattc aacagatact tacttgtcat actgtgcctg caaaacaata     3540

attagactct gaacaggtgc aacaattttc tgtagaatta gacaagtctt cttttggcag     3600

gtgttactaa gtaggccatt tcccaaggaa cagggaattt gccaggcttt tgtggtggag     3660

agaatagaat gaataaatgc tgtggggagt aaagagcttg tcagaagatg attagttctg     3720

tggcaccaaa accaagagat cagttttcct gtgagaagta aaggaagcat tgtagaaaaa     3780

tagatgtgtt gaagtctacc ggtggagttc cgcgttacat aacttacggt aaatggcccg     3840

cctggctgac cgcccaacga cccccgccca ttgacgtcaa taatgacgta tgttcccata     3900

gtaacgccaa tagggacttt ccattgacgt caatgggtgg agtatttacg gtaaactgcc     3960

cacttggcag tacatcaagt gtatcatatg ccaagtacgc cccctattga cgtcaatgac     4020

ggtaaatggc ccgcctggca ttatgcccag tacatgacct tatgggactt tcctacttgg     4080

cagtacatct acgtattagt catcgctatt accattgtga tgcggttttg gcagtacatc     4140

aatgggcgtg gatagcggtt tgactcacgg ggatttccaa gtctccaccc cattgacgtc     4200

aatgggagtt tgttttggca ccaaaatcaa cgggactttc caaaatgtcg taacaactcc     4260

gccccattga cgcaaatggg cggtaggcgt gtacggtggg aggtctatat aagcagagct     4320

cgtttagtga accgtcagat ctacctcttc cgcatcgctg tctgcgaggg ccagctgttg     4380

gggtgagtac tccctctcaa aagcgggcat gacttctgcg ctaagattgt cagtttccaa     4440

aaacgaggag gatttgatat tcacctggcc cgcggtgatg cctttgaggg tggccgcgtc     4500

catctggtca gaaaagacaa tctttttgtt gtcaagcttc cttgatgatg tcatacttat     4560

cctgtccctt ttttttccac agctcgcggt tgaggacaaa ctcttcgcgg tctttccagt     4620

actcttggat cggaaacccg tcggcctccg aacggtactc cgccaccgag ggacctgagc     4680

gagtccgcat cgaccggatc ggaaaacctc ggatccgaat tcatagataa ctgatccagt     4740

gcccctaacg ttactggccg aagccgcttg gaataaggcc ggtgtgcgtt tgtctatatg     4800

ttattttcca ccatattgcc gtcttttggc aatgtgaggg cccggaaacc tggccctgtc     4860

ttcttgacga gcattcctag gggtctttcc cctctcgcca aaggaatgca aggtctgttg     4920

aatgtcgtga aggaagcagt tcctctggaa gcttcttgaa gacaaacaac gtctgtagcg     4980

accctttgca ggcagcggaa ccccccacct ggcgacaggt gcctctgcgg ccaaaagcca     5040

cgtgtataag atacacctgc aaaggcggca caaccccagt gccacgttgt gagttggata     5100

gttgtggaaa gagtcaaatg gctctcctca agcgtattca acaaggggct gaaggatgcc     5160

cagaaggtac cccattgtat gggatctgat ctggggcctc ggtgcacatg ctttacatgt     5220

gtttagtcga ggttaaaaaa cgtctaggcc ccccgaacca cggggacgtg gttttccttt     5280

gaaaaacacg atggccacct cagcaagttc ccacttgaac aaaaacatca agcaaatgta     5340

cttgtgcctg ccccagggtg agaaagtcca agccatgtat atctgggttg atggtactgg     5400

agaaggactg cgctgcaaaa cccgcaccct ggactgtgag cccaagtgtg tagaagagtt     5460

acctgagtgg aattttgatg gctctagtac ctttcagtct gagggctcca acagtgacat     5520

gtatctcagc cctgttgcca tgtttcggga ccccttccgc agagatccca acaagctggt     5580

gttctgtgaa gttttcaagt acaaccggaa gcctgcagag accaatttaa ggcactcgtg     5640

taaacggata atggacatgg tgagcaacca gcacccctgg tttggaatgg aacaggagta     5700

tactctgatg ggaacagatg ggcacccttt tggttggcct tccaatggct ttcctgggcc     5760

ccaaggtccg tattactgtg gtgtgggcgc agacaaagcc tatggcaggg atatcgtgga     5820

ggctcactac cgcgcctgct tgtatgctgg ggtcaagatt acaggaacaa atgctgaggt     5880

catgcctgcc cagtgggagt tccaaatagg accctgtgaa ggaatccgca tgggagatca     5940

tctctgggtg gcccgtttca tcttgcatcg agtatgtgaa gactttgggg taatagcaac     6000

ctttgacccc aagcccattc ctgggaactg gaatggtgca ggctgccata ccaactttag     6060

caccaaggcc atgcgggagg agaatggtct gaagcacatc gaggaggcca tcgagaaact     6120

aagcaagcgg caccggtacc acattcgagc ctacgatccc aaggggggcc tggacaatgc     6180

ccgtcgtctg actgggttcc acgaaacgtc caacatcaac gacttttctg ctggtgtcgc     6240

caatcgcagt gccagcatcc gcattccccg gactgtcggc caggagaaga aaggttactt     6300

tgaagaccgc cgcccctctg ccaattgtga cccctttgca gtgacagaag ccatcgtccg     6360

cacatgcctt ctcaatgaga ctggcgacga gcccttccaa tacaaaaact aatctagatc     6420

cccctcgctt tcttgctgtc caatttctat taaaggttcc tttgttccct aagtccaact     6480

actaaactgg gggatattat gaagggcctt gagcatctgg attctgccta ataaaaaaca     6540

tttattttca ttgcaatgat gtatttaaat tatttctgaa tattttacta aaaagggaat     6600

gtgggaggtc agtgcattta aaacataaag aaatgaagag ggggatcttc gcgacctgca     6660

ggtctcccta tagtgagtcg tattaatttc gataagccag ctgcattaat gaatcggcca     6720

acgcgcgggg agaggcggtt tgcgtattgg gcgctcttcc gcttcctcgc tcactgactc     6780

gctgcgctcg gtcgttcggc tgcggcgagc ggtatcagct cactcaaagg cggtaatacg     6840

gttatccaca gaatcagggg ataacgcagg aaagaacatg tgagcaaaag gccagcaaaa     6900

ggccaggaac cgtaaaaagg ccgcgttgct ggcgtttttc cataggctcc gcccccctga     6960

cgagcatcac aaaaatcgac gctcaagtca gaggtggcga aacccgacag gactataaag     7020

ataccaggcg tttccccctg gaagctccct cgtgcgctct cctgttccga ccctgccgct     7080

taccggatac ctgtccgcct ttctcccttc gggaagcgtg gcgctttctc atagctcacg     7140

ctgtaggtat ctcagttcgg tgtaggtcgt tcgctccaag ctgggctgtg tgcacgaacc     7200

ccccgttcag cccgaccgct gcgccttatc cggtaactat cgtcttgagt ccaacccggt     7260

aagacacgac ttatcgccac tggcagcagc cactggtaac aggattagca gagcgaggta     7320

tgtaggcggt gctacagagt tcttgaagtg gtggcctaac tacggctaca ctagaaggac     7380

agtatttggt atctgcgctc tgctgaagcc agttaccttc ggaaaaagag ttggtagctc     7440

ttgatccggc aaacaaacca ccgctggtag cggtggtttt tttgtttgca agcagcagat     7500

tacgcgcaga aaaaaaggat ctcaagaaga tcctttgatc ttttctacgg ggtctgacgc     7560

tcagtggaac gaaaactcac gttaagggat tttggtcatg agattatcaa aaaggatctt     7620

cacctagatc cttttaaatt aaaaatgaag ttttaaatca atctaaagta tatatgagta     7680

aacttggtct gacagttacc aatgcttaat cagtgaggca cctatctcag cgatctgtct     7740

atttcgttca tccatagttg cctgactccc cgtcgtgtag ataactacga tacgggaggg     7800

cttaccatct ggccccagtg ctgcaatgat accgcgagac ccacgctcac cggctccaga     7860

tttatcagca ataaaccagc cagccggaag ggccgagcgc agaagtggtc ctgcaacttt     7920

atccgcctcc atccagtcta ttaattgttg ccgggaagct agagtaagta gttcgccagt     7980

taatagtttg cgcaacgttg ttgccattgc tacaggcatc gtggtgtcac gctcgtcgtt     8040

tggtatggct tcattcagct ccggttccca acgatcaagg cgagttacat gatcccccat     8100

gttgtgcaaa aaagcggtta gctccttcgg tcctccgatc gttgtcagaa gtaagttggc     8160

cgcagtgtta tcactcatgg ttatggcagc actgcataat tctcttactg tcatgccatc     8220

cgtaagatgc ttttctgtga ctggtgagta ctcaaccaag tcattctgag aatagtgtat     8280

gcggcgaccg agttgctctt gcccggcgtc aatacgggat aataccgcgc cacatagcag     8340

aactttaaaa gtgctcatca ttggaaaacg ttcttcgggg cgaaaactct caaggatctt     8400

accgctgttg agatccagtt cgatgtaacc cactcgtgca cccaactgat cttcagcatc     8460

ttttactttc accagcgttt ctgggtgagc aaaaacagga aggcaaaatg ccgcaaaaaa     8520

gggaataagg gcgacacgga aatgttgaat actcatactc ttcctttttc aatattattg     8580

aagcatttat cagggttatt gtctcatgag cggatacata tttgaatgta tttagaaaaa     8640

taaacaaata ggggttccgc gcacatttcc ccgaaaagtg ccacctgacg tctaagaaac     8700

cattattatc atgacattaa cctataaaaa taggcgtatc acgaggccct ttcgtctcgc     8760

gcgtttcggt gatgacggtg aaaacctctg acacatgcag ctcccggaga cggtcacagc     8820

ttgtctgtaa gcggatgccg ggagcagaca agcccgtcag ggcgcgtcag cgggtgttgg     8880

cgggtgtcgg ggctggctta actatgcggc atcagagcag attgtactga gagtgcacca     8940

tatcgacgct ctcccttatg cgactcctgc attaggaagc agcccagtag taggttgagg     9000

ccgttgagca ccgccgccgc aaggaatggt gcatgcaagg agatggcgcc caacagtccc     9060

ccggccacgg ggcctgccac catacccacg ccgaaacaag cgctcatgag cccgaagtgg     9120

cgagcccgat cttccccatc ggtgatgtcg gcgatatagg cgccagcaac cgcacctgtg     9180

gcgccggtga tgccggccac gatgcgtccg gcgtagagga tctggctagc gatgaccctg     9240

ctgattggtt cgctgaccat ttccggggtg cggaacggcg ttaccagaaa ctcagaaggt     9300

tcgtccaacc aaaccgactc tgacggcagt ttacgagaga gatgataggg tctgcttcag     9360

taagccagat gctacacaat taggcttgta catattgtcg ttagaacgcg gctacaatta     9420

atacataacc ttatgtatca tacacatacg atttaggtga cactatagaa tacacctgca     9480

ggacgcgtac tgagagcgct attctgaact tttcttttgt tc                        9522


<210>  7
<211>  10767
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  pCLD12

<400>  7
ccctagaaag ataatcatat tgtgacgtac gttaaagata atcatgcgta aaattgacgc       60

atgtgtttta tcggtctgta tatcgaggtt tatttattaa tttgaataga tattaagttt      120

tattatattt acacttacat actaataata aattcaacaa acaatttatt tatgtttatt      180

tatttattaa aaaaaaacaa aaactcaaaa tttcttctat aaagtaacaa aacttttatc      240

gaatttgcag cccgggacta gctagaggga cagccccccc ccaaagcccc cagggatgta      300

attacgtccc tcccccgcta gggggcagca gcgagccgcc cggggctccg ctccggtccg      360

gcgctccccc cgcatccccg agccggcagc gtgcggggac agcccgggca cggggaaggt      420

ggcacgggat cgctttcctc tgaacgcttc tcgctgctct ttgagcctgc agacacctgg      480

ggggatacgg ggaaaactta agatccgacc ggacgcgtac tgagagcgct attctgaact      540

tttcttttgt tcccttccct tctaccacac cctaattgta atccatttta atttcctggt      600

cacagtcctg tctctccttc cattgtacct tgcccttttc taaagagcga ctgcaaagta      660

tgtttgcgta ggtgaggatc taaaacttta tgaggtacga acatcacaga attactttgt      720

aatttcagtt tattgtaggc ttggcttttt ggggagggtt tacgtcttag acctcttagt      780

gcttctttgt ttcatggtgt tctaacttcg aagcatctct gtagctttaa tggattcctt      840

ttctgaaagc tttgctctct ttcttccccc tcggctttct cttaggcaag agggctaact      900

gtaaagtaag gcttactgcc ttgtgtttcc aaatgtgtcc gaagaggaag tgtcttctgt      960

gaatcctgtt atgcatgaat aacaggaaat agaaagaaat tcactttcat tattataaaa     1020

gtaatatgtt cgtttaaaaa attctaatga agagctggag atgcaaccca ggggtagagc     1080

acacactcag catgcaggag gccctgggtc caatcttgga atctcctctc agttaacctg     1140

atctctagct gattagtagt gagtgcaagc ccactttcct cttctgcctc attgctcagt     1200

gataacagct gttaaacttt gtcttattct aaaactacct ctgtgcaaat gctagcacaa     1260

taatatatat catatgcaca tgattttttt tttatcttga aaagtaagtc agtatagcta     1320

caaagttcac ttggcattgt caacatttca caggcgtaat attcctcctc tagtactgtc     1380

ctcttcattc tttgtgacca agtttggaga gagtgcacaa atgccaggga ggtttgtggg     1440

aaggtttctc atgttctggt aaggcgagta agaaaatagt ctcatgcagg tgaaatgagt     1500

gctatgcagt atatattata ccagagaaca gcaaatgacc aaattcacac tgaactagtt     1560

cagtaaaatt ggctttgtca aagctttcct tgcttaaaat gtaattccct gtcatcctag     1620

ttctggtctg gattcttttc ctggagtctt gacttccaga ttccctgtgg acttttgttt     1680

gagtttcaag cttttgaaat atagaaacct atctaactta acaaacttgg gagagaaaag     1740

actccagaac aactgaaaac agaccaggct aaatgaatag actttattcc tctcttctta     1800

cctgcagttt tcagatatgc agagttggag cggatcttag aggttgattc attcatgcct     1860

gaagaaaaca cattttatag accctgtgcc caagttcgtg gtggacatca ccctttattt     1920

actaattgca ctacataaca ggcattttag aagactgctc cagtcagaga ccccgcctta     1980

gaggaatctg taaaccctga actcctatca ctcatgagca ctagttatgt ttggaatgcc     2040

gtattaaaac aaaagttaca tttctaaact taaaattttc tagcacagag acagtgggag     2100

tagctaactt tgatagacat ttttctacta aaagtctttc taagtacata atcttctgta     2160

agttggaaaa cagcaaaata gaacgtctcc tacgtagtta atctttttgc ataatttgca     2220

catgtaggag ttattagtat acgggtaagt tttcactttt tcccccaact ggagtgtctt     2280

gtggctgggt ttgaaaaagg gaacgggagg ccgctggagg ggattggtaa atgagataaa     2340

acaccactca ttcaactcag tgactcagca tttaaatttt ccataaaagg attaaaggaa     2400

aattaaacaa attcttaaag ccaagactct ggagaaactt gttggtgtgc tttagttttc     2460

actgttatga ctcatgaatt tatgcataaa ttagtacatt tataaaaaca tagccttttt     2520

agagttttct gtttggctaa agtgccattg ttagcatttg gaattacctt tttatgtctt     2580

atattttttc caaataaaaa taaatgtttc tgctgtctta ctactgaaac tacgttgtga     2640

gcactttaaa tttctcaaag cagtttcgcc tgttatactt ggcgcttagt catcgtcgta     2700

cacaacagga cctgattaag aaggctgtgc tgcctctaag ccgggctaga ttgtagccac     2760

tagcaaccag gctgcaataa tttccctttg atgacatcat ccactgtgga agaacccagt     2820

tgcttcagcc agtcgaacta tacagttcca acctcatcaa atatggcatc tcccttgcct     2880

gctatagcag ggggaggaaa aaatgccacc atctttttaa tctagcaagc ttctcttttc     2940

ttcatctttt tttttttctt ttaaaaaaat tctgatcatg gatgcttctt ccgatcccta     3000

tttgccttat gacgggggag gagacaatat ccccttgagg gaattacata aaagaggtaa     3060

gagcatcccc ttgctctgaa tcctctgttg gttgttgtgc atgcggctgg gcggttctgg     3120

ggacaggctg tctgttgtcc tcttgctgca atgtgctgct tagttgccct gccttgttgc     3180

tgtgggagaa tgcgaccttc ccagcagggc tggccctccc tgattgtttg ctctgtgcag     3240

attagccctg cttcagatca catagggctg cagactccat cttctgtgtg aaaatgcttt     3300

cggtttgatt gcagaaataa gctgccttta cagccagcta aagtcctggt ggttggttgg     3360

cacctgcaaa gtagtatttt tgtacctctg gaaacttata ttttctttac acagcaatat     3420

caagtgccgg tatgccattc tgttttggct gctgccaatt accatgtaga ctttgcacca     3480

cagagtaata gtaaaagctc ctagctgcat tttataacat ttaaaaatag caggaaagaa     3540

gaattatttt tgatttaaca tgtttttgtc atttaacgtc ttaactgatt gacatactat     3600

attgtctgtc tcgtgggtat cttgtacaac ttgataggat aaagcaattt agtttttttt     3660

ttttttttta aatacatcca gaatgtaagt cgtcagtagt tttcgaacag ataagtaatg     3720

gtgttaatct tttggcaggc tttgccttgg tctccttaaa gctaattagg tgttacttaa     3780

ttaaactgct cttttgctca ttttcttaaa ttattttttt aaaagatagt tggcatttgc     3840

tgttctagaa ataaacttca agaaacattc tttagccaga tgacttcatg tatgagccat     3900

gttagtttga attatttgct tggtgttata aactttatgg tttaatacca acttttatta     3960

tgtttacaag gtaaataagg aaaatttcaa gtacattttg tatcctgaga acaaatttaa     4020

gttccataga atttaggaat tacaatgtat tcaacagata cttacttgtc atactgtgcc     4080

tgcaaaacaa taattagact ctgaacaggt gcaacaattt tctgtagaat tagacaagtc     4140

ttcttttggc aggtgttact aagtaggcca tttcccaagg aacagggaat ttgccaggct     4200

tttgtggtgg agagaataga atgaataaat gctgtgggga gtaaagagct tgtcagaaga     4260

tgattagttc tgtggcacca aaaccaagag atcagttttc ctgtgagaag taaaggaagc     4320

attgtagaaa aatagatgtg ttgaagtcta ccggtggagt tccgcgttac ataacttacg     4380

gtaaatggcc cgcctggctg accgcccaac gacccccgcc cattgacgtc aataatgacg     4440

tatgttccca tagtaacgcc aatagggact ttccattgac gtcaatgggt ggagtattta     4500

cggtaaactg cccacttggc agtacatcaa gtgtatcata tgccaagtac gccccctatt     4560

gacgtcaatg acggtaaatg gcccgcctgg cattatgccc agtacatgac cttatgggac     4620

tttcctactt ggcagtacat ctacgtatta gtcatcgcta ttaccattgt gatgcggttt     4680

tggcagtaca tcaatgggcg tggatagcgg tttgactcac ggggatttcc aagtctccac     4740

cccattgacg tcaatgggag tttgttttgg caccaaaatc aacgggactt tccaaaatgt     4800

cgtaacaact ccgccccatt gacgcaaatg ggcggtaggc gtgtacggtg ggaggtctat     4860

ataagcagag ctcgtttagt gaaccgtcag atctacctct tccgcatcgc tgtctgcgag     4920

ggccagctgt tggggtgagt actccctctc aaaagcgggc atgacttctg cgctaagatt     4980

gtcagtttcc aaaaacgagg aggatttgat attcacctgg cccgcggtga tgcctttgag     5040

ggtggccgcg tccatctggt cagaaaagac aatctttttg ttgtcaagct tccttgatga     5100

tgtcatactt atcctgtccc ttttttttcc acagctcgcg gttgaggaca aactcttcgc     5160

ggtctttcca gtactcttgg atcggaaacc cgtcggcctc cgaacggtac tccgccaccg     5220

agggacctga gcgagtccgc atcgaccgga tcggaaaacc tcggatccga attcatagat     5280

aactgatcca gtgcccctaa cgttactggc cgaagccgct tggaataagg ccggtgtgcg     5340

tttgtctata tgttattttc caccatattg ccgtcttttg gcaatgtgag ggcccggaaa     5400

cctggccctg tcttcttgac gagcattcct aggggtcttt cccctctcgc caaaggaatg     5460

caaggtctgt tgaatgtcgt gaaggaagca gttcctctgg aagcttcttg aagacaaaca     5520

acgtctgtag cgaccctttg caggcagcgg aaccccccac ctggcgacag gtgcctctgc     5580

ggccaaaagc cacgtgtata agatacacct gcaaaggcgg cacaacccca gtgccacgtt     5640

gtgagttgga tagttgtgga aagagtcaaa tggctctcct caagcgtatt caacaagggg     5700

ctgaaggatg cccagaaggt accccattgt atgggatctg atctggggcc tcggtgcaca     5760

tgctttacat gtgtttagtc gaggttaaaa aacgtctagg ccccccgaac cacggggacg     5820

tggttttcct ttgaaaaaca cgatgataat atggccacaa ccatggccac ctcagcaagt     5880

tcccacttga acaaaaacat caagcaaatg tacttgtgcc tgccccaggg tgagaaagtc     5940

caagccatgt atatctgggt tgatggtact ggagaaggac tgcgctgcaa aacccgcacc     6000

ctggactgtg agcccaagtg tgtagaagag ttacctgagt ggaattttga tggctctagt     6060

acctttcagt ctgagggctc caacagtgac atgtatctca gccctgttgc catgtttcgg     6120

gaccccttcc gcagagatcc caacaagctg gtgttctgtg aagttttcaa gtacaaccgg     6180

aagcctgcag agaccaattt aaggcactcg tgtaaacgga taatggacat ggtgagcaac     6240

cagcacccct ggtttggaat ggaacaggag tatactctga tgggaacaga tgggcaccct     6300

tttggttggc cttccaatgg ctttcctggg ccccaaggtc cgtattactg tggtgtgggc     6360

gcagacaaag cctatggcag ggatatcgtg gaggctcact accgcgcctg cttgtatgct     6420

ggggtcaaga ttacaggaac aaatgctgag gtcatgcctg cccagtggga gttccaaata     6480

ggaccctgtg aaggaatccg catgggagat catctctggg tggcccgttt catcttgcat     6540

cgagtatgtg aagactttgg ggtaatagca acctttgacc ccaagcccat tcctgggaac     6600

tggaatggtg caggctgcca taccaacttt agcaccaagg ccatgcggga ggagaatggt     6660

ctgaagcaca tcgaggaggc catcgagaaa ctaagcaagc ggcaccggta ccacattcga     6720

gcctacgatc ccaagggggg cctggacaat gcccgtcgtc tgactgggtt ccacgaaacg     6780

tccaacatca acgacttttc tgctggtgtc gccaatcgca gtgccagcat ccgcattccc     6840

cggactgtcg gccaggagaa gaaaggttac tttgaagacc gccgcccctc tgccaattgt     6900

gacccctttg cagtgacaga agccatcgtc cgcacatgcc ttctcaatga gactggcgac     6960

gagcccttcc aatacaaaaa ctaatctaga tccccctcgc tttcttgctg tccaatttct     7020

attaaaggtt cctttgttcc ctaagtccaa ctactaaact gggggatatt atgaagggcc     7080

ttgagcatct ggattctgcc taataaaaaa catttatttt cattgcaatg atgtatttaa     7140

attatttctg aatattttac taaaaaggga atgtgggagg tcagtgcatt taaaacataa     7200

agaaatgaag agggggatct tcgcgatact gcatcgatga gggacagccc ccccccaaag     7260

cccccaggga tgtaattacg tccctccccc gctagggggc agcagcgagc cgcccggggc     7320

tccgctccgg tccggcgctc cccccgcatc cccgagccgg cagcgtgcgg ggacagcccg     7380

ggcacgggga aggtggcacg ggatcgcttt cctctgaacg cttctcgctg ctctttgagc     7440

ctgcagacac ctggggggat acggggaaaa tagacaccgc ggtggagctc cagcttttgt     7500

tccctttagt gagggttaat tagttcttaa tacgactcac tatagggcga attggctacc     7560

gggccgccca tcgagggtat cataagctta tatctataac aagaaaatat atatataata     7620

agttatcacg taagtagaac atgaaataac aatataatta tcgtatgagt taaatcttaa     7680

aagtcacgta aaagataatc atgcgtcatt ttgactcacg cggtcgttat agttcaaaat     7740

cagtgacact taccgcattg acaagcacgc ctcacgggag ctccaagcgg cgactgagat     7800

gtcctaaatg cacagcgacg gattcgcgct atttagaaag agagagcaat atttcaagaa     7860

tgcatgcgtc aattttacgc agactatctt tctagggtta aatcgataga tgcgatcctg     7920

caggtctccc tatagtgagt cgtattaatt tcgataagcc agctgcatta atgaatcggc     7980

caacgcgcgg ggagaggcgg tttgcgtatt gggcgctctt ccgcttcctc gctcactgac     8040

tcgctgcgct cggtcgttcg gctgcggcga gcggtatcag ctcactcaaa ggcggtaata     8100

cggttatcca cagaatcagg ggataacgca ggaaagaaca tgtgagcaaa aggccagcaa     8160

aaggccagga accgtaaaaa ggccgcgttg ctggcgtttt tccataggct ccgcccccct     8220

gacgagcatc acaaaaatcg acgctcaagt cagaggtggc gaaacccgac aggactataa     8280

agataccagg cgtttccccc tggaagctcc ctcgtgcgct ctcctgttcc gaccctgccg     8340

cttaccggat acctgtccgc ctttctccct tcgggaagcg tggcgctttc tcatagctca     8400

cgctgtaggt atctcagttc ggtgtaggtc gttcgctcca agctgggctg tgtgcacgaa     8460

ccccccgttc agcccgaccg ctgcgcctta tccggtaact atcgtcttga gtccaacccg     8520

gtaagacacg acttatcgcc actggcagca gccactggta acaggattag cagagcgagg     8580

tatgtaggcg gtgctacaga gttcttgaag tggtggccta actacggcta cactagaagg     8640

acagtatttg gtatctgcgc tctgctgaag ccagttacct tcggaaaaag agttggtagc     8700

tcttgatccg gcaaacaaac caccgctggt agcggtggtt tttttgtttg caagcagcag     8760

attacgcgca gaaaaaaagg atctcaagaa gatcctttga tcttttctac ggggtctgac     8820

gctcagtgga acgaaaactc acgttaaggg attttggtca tgagattatc aaaaaggatc     8880

ttcacctaga tccttttaaa ttaaaaatga agttttaaat caatctaaag tatatatgag     8940

taaacttggt ctgacagtta ccaatgctta atcagtgagg cacctatctc agcgatctgt     9000

ctatttcgtt catccatagt tgcctgactc cccgtcgtgt agataactac gatacgggag     9060

ggcttaccat ctggccccag tgctgcaatg ataccgcgag acccacgctc accggctcca     9120

gatttatcag caataaacca gccagccgga agggccgagc gcagaagtgg tcctgcaact     9180

ttatccgcct ccatccagtc tattaattgt tgccgggaag ctagagtaag tagttcgcca     9240

gttaatagtt tgcgcaacgt tgttgccatt gctacaggca tcgtggtgtc acgctcgtcg     9300

tttggtatgg cttcattcag ctccggttcc caacgatcaa ggcgagttac atgatccccc     9360

atgttgtgca aaaaagcggt tagctccttc ggtcctccga tcgttgtcag aagtaagttg     9420

gccgcagtgt tatcactcat ggttatggca gcactgcata attctcttac tgtcatgcca     9480

tccgtaagat gcttttctgt gactggtgag tactcaacca agtcattctg agaatagtgt     9540

atgcggcgac cgagttgctc ttgcccggcg tcaatacggg ataataccgc gccacatagc     9600

agaactttaa aagtgctcat cattggaaaa cgttcttcgg ggcgaaaact ctcaaggatc     9660

ttaccgctgt tgagatccag ttcgatgtaa cccactcgtg cacccaactg atcttcagca     9720

tcttttactt tcaccagcgt ttctgggtga gcaaaaacag gaaggcaaaa tgccgcaaaa     9780

aagggaataa gggcgacacg gaaatgttga atactcatac tcttcctttt tcaatattat     9840

tgaagcattt atcagggtta ttgtctcatg agcggataca tatttgaatg tatttagaaa     9900

aataaacaaa taggggttcc gcgcacattt ccccgaaaag tgccacctga cgtctaagaa     9960

accattatta tcatgacatt aacctataaa aataggcgta tcacgaggcc ctttcgtctc    10020

gcgcgtttcg gtgatgacgg tgaaaacctc tgacacatgc agctcccgga gacggtcaca    10080

gcttgtctgt aagcggatgc cgggagcaga caagcccgtc agggcgcgtc agcgggtgtt    10140

ggcgggtgtc ggggctggct taactatgcg gcatcagagc agattgtact gagagtgcac    10200

catatcgacg ctctccctta tgcgactcct gcattaggaa gcagcccagt agtaggttga    10260

ggccgttgag caccgccgcc gcaaggaatg gtgcatgcaa ggagatggcg cccaacagtc    10320

ccccggccac ggggcctgcc accataccca cgccgaaaca agcgctcatg agcccgaagt    10380

ggcgagcccg atcttcccca tcggtgatgt cggcgatata ggcgccagca accgcacctg    10440

tggcgccggt gatgccggcc acgatgcgtc cggcgtagag gatctggcta gcgatgaccc    10500

tgctgattgg ttcgctgacc atttccgggg tgcggaacgg cgttaccaga aactcagaag    10560

gttcgtccaa ccaaaccgac tctgacggca gtttacgaga gagatgatag ggtctgcttc    10620

agtaagccag atgctacaca attaggcttg tacatattgt cgttagaacg cggctacaat    10680

taatacataa ccttatgtat catacacata cgatttaggt gacactatag aatacacctg    10740

caggacgtcc caatgatctt aagttaa                                        10767


<210>  8
<211>  10747
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  pCLD14

<400>  8
ccctagaaag ataatcatat tgtgacgtac gttaaagata atcatgcgta aaattgacgc       60

atgtgtttta tcggtctgta tatcgaggtt tatttattaa tttgaataga tattaagttt      120

tattatattt acacttacat actaataata aattcaacaa acaatttatt tatgtttatt      180

tatttattaa aaaaaaacaa aaactcaaaa tttcttctat aaagtaacaa aacttttatc      240

gaatttgcag cccgggacta gctagaggga cagccccccc ccaaagcccc cagggatgta      300

attacgtccc tcccccgcta gggggcagca gcgagccgcc cggggctccg ctccggtccg      360

gcgctccccc cgcatccccg agccggcagc gtgcggggac agcccgggca cggggaaggt      420

ggcacgggat cgctttcctc tgaacgcttc tcgctgctct ttgagcctgc agacacctgg      480

ggggatacgg ggaaaactta agatccgacc ggacgcgtac tgagagcgct attctgaact      540

tttcttttgt tcccttccct tctaccacac cctaattgta atccatttta atttcctggt      600

cacagtcctg tctctccttc cattgtacct tgcccttttc taaagagcga ctgcaaagta      660

tgtttgcgta ggtgaggatc taaaacttta tgaggtacga acatcacaga attactttgt      720

aatttcagtt tattgtaggc ttggcttttt ggggagggtt tacgtcttag acctcttagt      780

gcttctttgt ttcatggtgt tctaacttcg aagcatctct gtagctttaa tggattcctt      840

ttctgaaagc tttgctctct ttcttccccc tcggctttct cttaggcaag agggctaact      900

gtaaagtaag gcttactgcc ttgtgtttcc aaatgtgtcc gaagaggaag tgtcttctgt      960

gaatcctgtt atgcatgaat aacaggaaat agaaagaaat tcactttcat tattataaaa     1020

gtaatatgtt cgtttaaaaa attctaatga agagctggag atgcaaccca ggggtagagc     1080

acacactcag catgcaggag gccctgggtc caatcttgga atctcctctc agttaacctg     1140

atctctagct gattagtagt gagtgcaagc ccactttcct cttctgcctc attgctcagt     1200

gataacagct gttaaacttt gtcttattct aaaactacct ctgtgcaaat gctagcacaa     1260

taatatatat catatgcaca tgattttttt tttatcttga aaagtaagtc agtatagcta     1320

caaagttcac ttggcattgt caacatttca caggcgtaat attcctcctc tagtactgtc     1380

ctcttcattc tttgtgacca agtttggaga gagtgcacaa atgccaggga ggtttgtggg     1440

aaggtttctc atgttctggt aaggcgagta agaaaatagt ctcatgcagg tgaaatgagt     1500

gctatgcagt atatattata ccagagaaca gcaaatgacc aaattcacac tgaactagtt     1560

cagtaaaatt ggctttgtca aagctttcct tgcttaaaat gtaattccct gtcatcctag     1620

ttctggtctg gattcttttc ctggagtctt gacttccaga ttccctgtgg acttttgttt     1680

gagtttcaag cttttgaaat atagaaacct atctaactta acaaacttgg gagagaaaag     1740

actccagaac aactgaaaac agaccaggct aaatgaatag actttattcc tctcttctta     1800

cctgcagttt tcagatatgc agagttggag cggatcttag aggttgattc attcatgcct     1860

gaagaaaaca cattttatag accctgtgcc caagttcgtg gtggacatca ccctttattt     1920

actaattgca ctacataaca ggcattttag aagactgctc cagtcagaga ccccgcctta     1980

gaggaatctg taaaccctga actcctatca ctcatgagca ctagttatgt ttggaatgcc     2040

gtattaaaac aaaagttaca tttctaaact taaaattttc tagcacagag acagtgggag     2100

tagctaactt tgatagacat ttttctacta aaagtctttc taagtacata atcttctgta     2160

agttggaaaa cagcaaaata gaacgtctcc tacgtagtta atctttttgc ataatttgca     2220

catgtaggag ttattagtat acgggtaagt tttcactttt tcccccaact ggagtgtctt     2280

gtggctgggt ttgaaaaagg gaacgggagg ccgctggagg ggattggtaa atgagataaa     2340

acaccactca ttcaactcag tgactcagca tttaaatttt ccataaaagg attaaaggaa     2400

aattaaacaa attcttaaag ccaagactct ggagaaactt gttggtgtgc tttagttttc     2460

actgttatga ctcatgaatt tatgcataaa ttagtacatt tataaaaaca tagccttttt     2520

agagttttct gtttggctaa agtgccattg ttagcatttg gaattacctt tttatgtctt     2580

atattttttc caaataaaaa taaatgtttc tgctgtctta ctactgaaac tacgttgtga     2640

gcactttaaa tttctcaaag cagtttcgcc tgttatactt ggcgcttagt catcgtcgta     2700

cacaacagga cctgattaag aaggctgtgc tgcctctaag ccgggctaga ttgtagccac     2760

tagcaaccag gctgcaataa tttccctttg atgacatcat ccactgtgga agaacccagt     2820

tgcttcagcc agtcgaacta tacagttcca acctcatcaa atatggcatc tcccttgcct     2880

gctatagcag ggggaggaaa aaatgccacc atctttttaa tctagcaagc ttctcttttc     2940

ttcatctttt tttttttctt ttaaaaaaat tctgatcatg gatgcttctt ccgatcccta     3000

tttgccttat gacgggggag gagacaatat ccccttgagg gaattacata aaagaggtaa     3060

gagcatcccc ttgctctgaa tcctctgttg gttgttgtgc atgcggctgg gcggttctgg     3120

ggacaggctg tctgttgtcc tcttgctgca atgtgctgct tagttgccct gccttgttgc     3180

tgtgggagaa tgcgaccttc ccagcagggc tggccctccc tgattgtttg ctctgtgcag     3240

attagccctg cttcagatca catagggctg cagactccat cttctgtgtg aaaatgcttt     3300

cggtttgatt gcagaaataa gctgccttta cagccagcta aagtcctggt ggttggttgg     3360

cacctgcaaa gtagtatttt tgtacctctg gaaacttata ttttctttac acagcaatat     3420

caagtgccgg tatgccattc tgttttggct gctgccaatt accatgtaga ctttgcacca     3480

cagagtaata gtaaaagctc ctagctgcat tttataacat ttaaaaatag caggaaagaa     3540

gaattatttt tgatttaaca tgtttttgtc atttaacgtc ttaactgatt gacatactat     3600

attgtctgtc tcgtgggtat cttgtacaac ttgataggat aaagcaattt agtttttttt     3660

ttttttttta aatacatcca gaatgtaagt cgtcagtagt tttcgaacag ataagtaatg     3720

gtgttaatct tttggcaggc tttgccttgg tctccttaaa gctaattagg tgttacttaa     3780

ttaaactgct cttttgctca ttttcttaaa ttattttttt aaaagatagt tggcatttgc     3840

tgttctagaa ataaacttca agaaacattc tttagccaga tgacttcatg tatgagccat     3900

gttagtttga attatttgct tggtgttata aactttatgg tttaatacca acttttatta     3960

tgtttacaag gtaaataagg aaaatttcaa gtacattttg tatcctgaga acaaatttaa     4020

gttccataga atttaggaat tacaatgtat tcaacagata cttacttgtc atactgtgcc     4080

tgcaaaacaa taattagact ctgaacaggt gcaacaattt tctgtagaat tagacaagtc     4140

ttcttttggc aggtgttact aagtaggcca tttcccaagg aacagggaat ttgccaggct     4200

tttgtggtgg agagaataga atgaataaat gctgtgggga gtaaagagct tgtcagaaga     4260

tgattagttc tgtggcacca aaaccaagag atcagttttc ctgtgagaag taaaggaagc     4320

attgtagaaa aatagatgtg ttgaagtcta ccggtggagt tccgcgttac ataacttacg     4380

gtaaatggcc cgcctggctg accgcccaac gacccccgcc cattgacgtc aataatgacg     4440

tatgttccca tagtaacgcc aatagggact ttccattgac gtcaatgggt ggagtattta     4500

cggtaaactg cccacttggc agtacatcaa gtgtatcata tgccaagtac gccccctatt     4560

gacgtcaatg acggtaaatg gcccgcctgg cattatgccc agtacatgac cttatgggac     4620

tttcctactt ggcagtacat ctacgtatta gtcatcgcta ttaccattgt gatgcggttt     4680

tggcagtaca tcaatgggcg tggatagcgg tttgactcac ggggatttcc aagtctccac     4740

cccattgacg tcaatgggag tttgttttgg caccaaaatc aacgggactt tccaaaatgt     4800

cgtaacaact ccgccccatt gacgcaaatg ggcggtaggc gtgtacggtg ggaggtctat     4860

ataagcagag ctcgtttagt gaaccgtcag atctacctct tccgcatcgc tgtctgcgag     4920

ggccagctgt tggggtgagt actccctctc aaaagcgggc atgacttctg cgctaagatt     4980

gtcagtttcc aaaaacgagg aggatttgat attcacctgg cccgcggtga tgcctttgag     5040

ggtggccgcg tccatctggt cagaaaagac aatctttttg ttgtcaagct tccttgatga     5100

tgtcatactt atcctgtccc ttttttttcc acagctcgcg gttgaggaca aactcttcgc     5160

ggtctttcca gtactcttgg atcggaaacc cgtcggcctc cgaacggtac tccgccaccg     5220

agggacctga gcgagtccgc atcgaccgga tcggaaaacc tcggatccga attcatagat     5280

aactgatcca gtgcccctaa cgttactggc cgaagccgct tggaataagg ccggtgtgcg     5340

tttgtctata tgttattttc caccatattg ccgtcttttg gcaatgtgag ggcccggaaa     5400

cctggccctg tcttcttgac gagcattcct aggggtcttt cccctctcgc caaaggaatg     5460

caaggtctgt tgaatgtcgt gaaggaagca gttcctctgg aagcttcttg aagacaaaca     5520

acgtctgtag cgaccctttg caggcagcgg aaccccccac ctggcgacag gtgcctctgc     5580

ggccaaaagc cacgtgtata agatacacct gcaaaggcgg cacaacccca gtgccacgtt     5640

gtgagttgga tagttgtgga aagagtcaaa tggctctcct caagcgtatt caacaagggg     5700

ctgaaggatg cccagaaggt accccattgt atgggatctg atctggggcc tcggtgcaca     5760

tgctttacat gtgtttagtc gaggttaaaa aacgtctagg ccccccgaac cacggggacg     5820

tggttttcct ttgaaaaaca cgatggccac ctcagcaagt tcccacttga acaaaaacat     5880

caagcaaatg tacttgtgcc tgccccaggg tgagaaagtc caagccatgt atatctgggt     5940

tgatggtact ggagaaggac tgcgctgcaa aacccgcacc ctggactgtg agcccaagtg     6000

tgtagaagag ttacctgagt ggaattttga tggctctagt acctttcagt ctgagggctc     6060

caacagtgac atgtatctca gccctgttgc catgtttcgg gaccccttcc gcagagatcc     6120

caacaagctg gtgttctgtg aagttttcaa gtacaaccgg aagcctgcag agaccaattt     6180

aaggcactcg tgtaaacgga taatggacat ggtgagcaac cagcacccct ggtttggaat     6240

ggaacaggag tatactctga tgggaacaga tgggcaccct tttggttggc cttccaatgg     6300

ctttcctggg ccccaaggtc cgtattactg tggtgtgggc gcagacaaag cctatggcag     6360

ggatatcgtg gaggctcact accgcgcctg cttgtatgct ggggtcaaga ttacaggaac     6420

aaatgctgag gtcatgcctg cccagtggga gttccaaata ggaccctgtg aaggaatccg     6480

catgggagat catctctggg tggcccgttt catcttgcat cgagtatgtg aagactttgg     6540

ggtaatagca acctttgacc ccaagcccat tcctgggaac tggaatggtg caggctgcca     6600

taccaacttt agcaccaagg ccatgcggga ggagaatggt ctgaagcaca tcgaggaggc     6660

catcgagaaa ctaagcaagc ggcaccggta ccacattcga gcctacgatc ccaagggggg     6720

cctggacaat gcccgtcgtc tgactgggtt ccacgaaacg tccaacatca acgacttttc     6780

tgctggtgtc gccaatcgca gtgccagcat ccgcattccc cggactgtcg gccaggagaa     6840

gaaaggttac tttgaagacc gccgcccctc tgccaattgt gacccctttg cagtgacaga     6900

agccatcgtc cgcacatgcc ttctcaatga gactggcgac gagcccttcc aatacaaaaa     6960

ctaatctaga tccccctcgc tttcttgctg tccaatttct attaaaggtt cctttgttcc     7020

ctaagtccaa ctactaaact gggggatatt atgaagggcc ttgagcatct ggattctgcc     7080

taataaaaaa catttatttt cattgcaatg atgtatttaa attatttctg aatattttac     7140

taaaaaggga atgtgggagg tcagtgcatt taaaacataa agaaatgaag agggggatct     7200

tcgcgatact gcatcgatga gggacagccc ccccccaaag cccccaggga tgtaattacg     7260

tccctccccc gctagggggc agcagcgagc cgcccggggc tccgctccgg tccggcgctc     7320

cccccgcatc cccgagccgg cagcgtgcgg ggacagcccg ggcacgggga aggtggcacg     7380

ggatcgcttt cctctgaacg cttctcgctg ctctttgagc ctgcagacac ctggggggat     7440

acggggaaaa tagacaccgc ggtggagctc cagcttttgt tccctttagt gagggttaat     7500

tagttcttaa tacgactcac tatagggcga attggctacc gggccgccca tcgagggtat     7560

cataagctta tatctataac aagaaaatat atatataata agttatcacg taagtagaac     7620

atgaaataac aatataatta tcgtatgagt taaatcttaa aagtcacgta aaagataatc     7680

atgcgtcatt ttgactcacg cggtcgttat agttcaaaat cagtgacact taccgcattg     7740

acaagcacgc ctcacgggag ctccaagcgg cgactgagat gtcctaaatg cacagcgacg     7800

gattcgcgct atttagaaag agagagcaat atttcaagaa tgcatgcgtc aattttacgc     7860

agactatctt tctagggtta aatcgataga tgcgatcctg caggtctccc tatagtgagt     7920

cgtattaatt tcgataagcc agctgcatta atgaatcggc caacgcgcgg ggagaggcgg     7980

tttgcgtatt gggcgctctt ccgcttcctc gctcactgac tcgctgcgct cggtcgttcg     8040

gctgcggcga gcggtatcag ctcactcaaa ggcggtaata cggttatcca cagaatcagg     8100

ggataacgca ggaaagaaca tgtgagcaaa aggccagcaa aaggccagga accgtaaaaa     8160

ggccgcgttg ctggcgtttt tccataggct ccgcccccct gacgagcatc acaaaaatcg     8220

acgctcaagt cagaggtggc gaaacccgac aggactataa agataccagg cgtttccccc     8280

tggaagctcc ctcgtgcgct ctcctgttcc gaccctgccg cttaccggat acctgtccgc     8340

ctttctccct tcgggaagcg tggcgctttc tcatagctca cgctgtaggt atctcagttc     8400

ggtgtaggtc gttcgctcca agctgggctg tgtgcacgaa ccccccgttc agcccgaccg     8460

ctgcgcctta tccggtaact atcgtcttga gtccaacccg gtaagacacg acttatcgcc     8520

actggcagca gccactggta acaggattag cagagcgagg tatgtaggcg gtgctacaga     8580

gttcttgaag tggtggccta actacggcta cactagaagg acagtatttg gtatctgcgc     8640

tctgctgaag ccagttacct tcggaaaaag agttggtagc tcttgatccg gcaaacaaac     8700

caccgctggt agcggtggtt tttttgtttg caagcagcag attacgcgca gaaaaaaagg     8760

atctcaagaa gatcctttga tcttttctac ggggtctgac gctcagtgga acgaaaactc     8820

acgttaaggg attttggtca tgagattatc aaaaaggatc ttcacctaga tccttttaaa     8880

ttaaaaatga agttttaaat caatctaaag tatatatgag taaacttggt ctgacagtta     8940

ccaatgctta atcagtgagg cacctatctc agcgatctgt ctatttcgtt catccatagt     9000

tgcctgactc cccgtcgtgt agataactac gatacgggag ggcttaccat ctggccccag     9060

tgctgcaatg ataccgcgag acccacgctc accggctcca gatttatcag caataaacca     9120

gccagccgga agggccgagc gcagaagtgg tcctgcaact ttatccgcct ccatccagtc     9180

tattaattgt tgccgggaag ctagagtaag tagttcgcca gttaatagtt tgcgcaacgt     9240

tgttgccatt gctacaggca tcgtggtgtc acgctcgtcg tttggtatgg cttcattcag     9300

ctccggttcc caacgatcaa ggcgagttac atgatccccc atgttgtgca aaaaagcggt     9360

tagctccttc ggtcctccga tcgttgtcag aagtaagttg gccgcagtgt tatcactcat     9420

ggttatggca gcactgcata attctcttac tgtcatgcca tccgtaagat gcttttctgt     9480

gactggtgag tactcaacca agtcattctg agaatagtgt atgcggcgac cgagttgctc     9540

ttgcccggcg tcaatacggg ataataccgc gccacatagc agaactttaa aagtgctcat     9600

cattggaaaa cgttcttcgg ggcgaaaact ctcaaggatc ttaccgctgt tgagatccag     9660

ttcgatgtaa cccactcgtg cacccaactg atcttcagca tcttttactt tcaccagcgt     9720

ttctgggtga gcaaaaacag gaaggcaaaa tgccgcaaaa aagggaataa gggcgacacg     9780

gaaatgttga atactcatac tcttcctttt tcaatattat tgaagcattt atcagggtta     9840

ttgtctcatg agcggataca tatttgaatg tatttagaaa aataaacaaa taggggttcc     9900

gcgcacattt ccccgaaaag tgccacctga cgtctaagaa accattatta tcatgacatt     9960

aacctataaa aataggcgta tcacgaggcc ctttcgtctc gcgcgtttcg gtgatgacgg    10020

tgaaaacctc tgacacatgc agctcccgga gacggtcaca gcttgtctgt aagcggatgc    10080

cgggagcaga caagcccgtc agggcgcgtc agcgggtgtt ggcgggtgtc ggggctggct    10140

taactatgcg gcatcagagc agattgtact gagagtgcac catatcgacg ctctccctta    10200

tgcgactcct gcattaggaa gcagcccagt agtaggttga ggccgttgag caccgccgcc    10260

gcaaggaatg gtgcatgcaa ggagatggcg cccaacagtc ccccggccac ggggcctgcc    10320

accataccca cgccgaaaca agcgctcatg agcccgaagt ggcgagcccg atcttcccca    10380

tcggtgatgt cggcgatata ggcgccagca accgcacctg tggcgccggt gatgccggcc    10440

acgatgcgtc cggcgtagag gatctggcta gcgatgaccc tgctgattgg ttcgctgacc    10500

atttccgggg tgcggaacgg cgttaccaga aactcagaag gttcgtccaa ccaaaccgac    10560

tctgacggca gtttacgaga gagatgatag ggtctgcttc agtaagccag atgctacaca    10620

attaggcttg tacatattgt cgttagaacg cggctacaat taatacataa ccttatgtat    10680

catacacata cgatttaggt gacactatag aatacacctg caggacgtcc caatgatctt    10740

aagttaa                                                              10747


<210>  9
<211>  63
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  5'ITR

<400>  9
ccctagaaag ataatcatat tgtgacgtac gttaaagata atcatgcgta aaattgacgc       60

atg                                                                     63


<210>  10
<211>  35
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  3'ITR

<400>  10
catgcgtcaa ttttacgcag actatctttc taggg                                  35


<210>  11
<211>  1211
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HS4 Insulator

<400>  11
gagctcacgg ggacagcccc cccccaaagc ccccagggat gtaattacgt ccctcccccg       60

ctagggggca gcagcgagcc gcccggggct ccgctccggt ccggcgctcc ccccgcatcc      120

ccgagccggc agcgtgcggg gacagcccgg gcacggggaa ggtggcacgg gatcgctttc      180

ctctgaacgc ttctcgctgc tctttgagcc tgcagacacc tggggggata cggggaaaaa      240

gctttaggct gaaagagaga tttagaatga cagaatcata gaacggcctg ggttgcaaag      300

gagcacagtg ctcatccaga tccaaccccc tgctatgtgc agggtcatca accagcagcc      360

caggctgccc agagccacat ccagcctggc cttgaatgcc tgcagggatg gggcatccac      420

agcctccttg ggcaacctgt tcagtgcgtc accaccctct gggggaaaaa ctgcctcctc      480

atatccaacc caaacctccc ctgtctcagt gtaaagccat tcccccttgt cctatcaagg      540

gggagtttgc tgtgacattg ttggtctggg gtgacacatg tttgccaatt cagtgcatca      600

cggagaggca gatcttgggg ataaggaagt gcaggacagc atggacgtgg gacatgcagg      660

tgttgagggc tctgggacac tctccaagtc acagcgttca gaacagcctt aaggataaga      720

agataggata gaaggacaaa gagcaagtta aaacccagca tggagaggag cacaaaaagg      780

ccacagacac tgctggtccc tgtgtctgag cctgcatgtt tgatggtgtc tggatgcaag      840

cagaaggggt ggaagagctt gcctggagag atacagctgg gtcagtagga ctgggacagg      900

cagctggaga attgccatgt agatgttcat acaatcgtca aatcatgaag gctggaaaag      960

ccctccaaga tccccaagac caaccccaac ccacccaccg tgcccactgg ccatgtccct     1020

cagtgccaca tccccacagt tcttcatcac ctccagggac ggtgaccccc ccacctccgt     1080

gggcagctgt gccactgcag caccgctctt tggagaaggt aaatcttgct aaatccagcc     1140

cgaccctccc ctggcacaac gtaaggccat tatctctcat ccaactccag gacggagtca     1200

gtgagaatat t                                                          1211


<210>  12
<211>  5837
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  EASE

<400>  12
gaattctgaa cttttctttt gttcccttcc cttctaccac accctaattg taatccattt       60

taatttcctg gtcacagtcc tgtctctcct tccattgtac cttgcccttt tctaaagagc      120

gactgcaaag tatgtttgcg taggtgagga tctaaaactt tatgaggtac gaacatcaca      180

gaattacttt gtaatttcag tttattgtag gcttggcttt ttggggaggg tttacgtctt      240

agacctctta gtgcttcttt gtttcatggt gttctaactt cgaagcatct ctgtagcttt      300

aatggattcc ttttctgaaa gctttgctct ctttcttccc cctcggcttt ctcttaggca      360

agagggctaa ctgtaaagta aggcttactg ccttgtgttt ccaaatgtgt ccgaagagga      420

agtgtcttct gtgaatcctg ttatgcatga ataacaggaa atagaaagaa attcactttc      480

attattataa aagtaatatg ttcgtttaaa aaattctaat gaagagctgg agatgcaacc      540

caggggtaga gcacacactc agcatgcagg aggccctggg tccaatcttg gaatctcctc      600

tcagttaacc tgatctctag ctgattagta gtgagtgcaa gcccactttc ctcttctgcc      660

tcattgctca gtgataacag ctgttaaact ttgtcttatt ctaaaactac ctctgtgcaa      720

atgctagcac aataatatat atcatatgca catgattttt tttttatctt gaaaagtaag      780

tcagtatagc tacaaagttc acttggcatt gtcaacattt cacaggcgta atattcctcc      840

tctagtactg tcctcttcat tctttgtgac caagtttgga gagagtgcac aaatgccagg      900

gaggtttgtg ggaaggtttc tcatgttctg gtaaggcgag taagaaaata gtctcatgca      960

ggtgaaatga gtgctatgca gtatatatta taccagagaa cagcaaatga ccaaattcac     1020

actgaactag ttcagtaaaa ttggctttgt caaagctttc cttgcttaaa atgtaattcc     1080

ctgtcatcct agttctggtc tggattcttt tcctggagtc ttgacttcca gattccctgt     1140

ggacttttgt ttgagtttca agcttttgaa atatagaaac ctatctaact taacaaactt     1200

gggagagaaa agactccaga acaactgaaa acagaccagg ctaaatgaat agactttatt     1260

cctctcttct tacctgcagt tttcagatat gcagagttgg agcggatctt agaggttgat     1320

tcattcatgc ctgaagaaaa cacattttat agaccctgtg cccaagttcg tggtggacat     1380

caccctttat ttactaattg cactacataa caggcatttt agaagactgc tccagtcaga     1440

gaccccgcct tagaggaatc tgtaaaccct gaactcctat cactcatgag cactagttat     1500

gtttggaatg ccgtattaaa acaaaagtta catttctaaa cttaaaattt tctagcacag     1560

agacagtggg agtagctaac tttgatagac atttttctac taaaagtctt tctaagtaca     1620

taatcttctg taagttggaa aacagcaaaa tagaacgtct cctacgtagt taatcttttt     1680

gcataatttg cacatgtagg agttattagt atacgggtaa gttttcactt tttcccccaa     1740

ctggagtgtc ttgtggctgg gtttgaaaaa gggaacggga ggccgctgga ggggattggt     1800

aaatgagata aaacaccact cattcaactc agtgactcag catttaaatt ttccataaaa     1860

ggattaaagg aaaattaaac aaattcttaa agccaagact ctggagaaac ttgttggtgt     1920

gctttagttt tcactgttat gactcatgaa tttatgcata aattagtaca tttataaaaa     1980

catagccttt ttagagtttt ctgtttggct aaagtgccat tgttagcatt tggaattacc     2040

tttttatgtc ttatattttt tccaaataaa aataaatgtt tctgctgtct tactactgaa     2100

actacgttgt gagcacttta aatttctcaa agcagtttcg cctgttatac ttggcgctta     2160

gtcatcgtcg tacacaacag gacctgatta agaaggctgt gctgcctcta agccgggcta     2220

gattgtagcc actagcaacc aggctgcaat aatttccctt tgatgacatc atccactgtg     2280

gaagaaccca gttgcttcag ccagtcgaac tatacagttc caacctcatc aaatatggca     2340

tctcccttgc ctgctatagc agggggagga aaaaatgcca ccatcttttt aatctagcaa     2400

gcttctcttt tcttcatctt tttttttttc ttttaaaaaa attctgatca tggatgcttc     2460

ttccgatccc tatttgcctt atgacggggg aggagacaat atccccttga gggaattaca     2520

taaaagaggt aagagcatcc ccttgctctg aatcctctgt tggttgttgt gcatgcggct     2580

gggcggttct ggggacaggc tgtctgttgt cctcttgctg caatgtgctg cttagttgcc     2640

ctgccttgtt gctgtgggag aatgcgacct tcccagcagg gctggccctc cctgattgtt     2700

tgctctgtgc agattagccc tgcttcagat cacatagggc tgcagactcc atcttctgtg     2760

tgaaaatgct ttcggtttga ttgcagaaat aagctgcctt tacagccagc taaagtcctg     2820

gtggttggtt ggcacctgca aagtagtatt tttgtacctc tggaaactta tattttcttt     2880

acacagcaat atcaagtgcc ggtatgccat tctgttttgg ctgctgccaa ttaccatgta     2940

gactttgcac cacagagtaa tagtaaaagc tcctagctgc attttataac atttaaaaat     3000

agcaggaaag aagaattatt tttgatttaa catgtttttg tcatttaacg tcttaactga     3060

ttgacatact atattgtctg tctcgtgggt atcttgtaca acttgatagg ataaagcaat     3120

ttagtttttt tttttttttt taaatacatc cagaatgtaa gtcgtcagta gttttcgaac     3180

agataagtaa tggtgttaat cttttggcag gctttgcctt ggtctcctta aagctaatta     3240

ggtgttactt aattaaactg ctcttttgct cattttctta aattattttt ttaaaagata     3300

gttggcattt gctgttctag aaataaactt caagaaacat tctttagcca gatgacttca     3360

tgtatgagcc atgttagttt gaattatttg cttggtgtta taaactttat ggtttaatac     3420

caacttttat tatgtttaca aggtaaataa ggaaaatttc aagtacattt tgtatcctga     3480

gaacaaattt aagttccata gaatttagga attacaatgt attcaacaga tacttacttg     3540

tcatactgtg cctgcaaaac aataattaga ctctgaacag gtgcaacaat tttctgtaga     3600

attctgtgct tagtaaaagg ttgcttttta tattttgaga gaaatctatt taaagatcat     3660

ggcccatatt ttgtgcatat ttttttctgt ataccatttc catatatgtg tgtgtgtgta     3720

catatatgta tatatataaa atgttagaac atttgaggaa atagctaaaa gtacaaaagt     3780

aatgttttct aattttttac tccccgaggt tatttctttt ttccttgttt tcctttctct     3840

ttgttcctat catcagtttc tagtaatact cttattgaac agtgattatt caaatgtcac     3900

attatttatt aatcagcatt taaatggtaa aaccagacag accatacttt ctctgagtga     3960

tgacaacatc catttttagt aatgataaac tagaagggtc aggcttgata gtctttgtca     4020

ggactaattt atagactgta aaggccaaaa gaaataagaa atgtcaaaac tcttgtgaaa     4080

ctagacatac agatattacc aagagagaaa ctagaaaaaa aaattctgtg acatggcctt     4140

aatttgccag gcaccatcgt gaaggcctaa acccctctta gaagctcact cagatgccat     4200

cctgcttctc tgatgagact tcctgtcaat acaaacatgg tttaggaaga atgagtgttt     4260

gcagtataaa ccagttattt actagcctta ctttaagaat atactgtagt gtccttgaga     4320

gagaaggtgt ttgttttctg taatttatga cccttttgaa accatagatc agcacaaagg     4380

aactggggat atggaaatgg gaacataact taaatccaga aaagtgaatc agattccctg     4440

tgaggacaaa atgcaatatt tagaaatagg atctttaggc tgggagggag aaaagaggaa     4500

aaaaatgaaa gtataacatt tttcataagt ataagatttc ataaaaaaat gaaatctata     4560

acatagaggg tgttgataaa gtaagcatgg atatgtttag taaagccgac agagctaaga     4620

attagctttg tgagtaattg gacttaatca aacttttcaa ggtgggatac aaatgaataa     4680

ttgtagaata aatggataaa agaatatgaa taaaatgaat agtgagtaaa aattaaaaat     4740

gaagcttttt acttaagtgc atattgtagt ggctagaaca aatagattca aaatagaaat     4800

catttatata ttcttgatta gaagataaaa tgttatttta gaaatagcca tctttggaag     4860

taaatttgct atgttgaaca accaggtttt cataatttgt ctcttatttt ttttcaggaa     4920

gaaaaaaaaa cttgacttat ttgtactgct aagttttatt caatgtgctt gcttgcttaa     4980

atttttaatg aagttttagt catttggtgg tcaaattcct tttatctact aatcgctttt     5040

cgtggctttg gcttttaaaa ttgtatttac tgcatttatt tgtgtgtatt aggagtcagg     5100

tggccatatg tgccatggca tgtgtatgga agcacttgtg gacatgaatc ttctctttcc     5160

acatgtgtgg gccactggaa tcaaactagt gtcaggcttg gcagcaattt ttaatgcact     5220

gagccttctc accaccccct ggacttttgt ggggcagaag gggacaagtt taatatttta     5280

tttactccat gtagaaagcc tttaaaaaat gtagaaagcc tttaaactac ctattgtttt     5340

atttgaatta tgaagctctt gtgtttatat aaattacagt taggtactgt ggagactaat     5400

ggtagctaca atagtaatat taatagctaa aacttagtag aatctgattg agttaatttg     5460

gccctttcca tcataaggta ctcttcccaa gcatcacatg acctgtgctt aagtctggtg     5520

ggggcttatg gctttgatat tgaaaacaaa tcgtcaagga tgttaatttc ttgttactgc     5580

tattacactg aattttctat ggctctttag gagaggaaga gacaagtctt cttttggcag     5640

gtgttactaa gtaggccatt tcccaaggaa cagggaattt gccaggcttt tgtggtggag     5700

agaatagaat gaataaatgc tgtggggagt aaagagcttg tcagaagatg attagttctg     5760

tggcaccaaa accaagagat cagttttcct gtgagaagta aaggaagcat tgtagaaaaa     5820

tagatgtgtt gaagtct                                                    5837


<210>  13
<211>  280
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Beta-globin polyA

<400>  13
tgccctggcc cacaagtatc actaagctcg ctttcttgct gtccaatttc tattaaaggt       60

tcctttgttc cctaagtcca actactaaac tgggggatat tatgaagggc cttgagcatc      120

tggattctgc ctaataaaaa acatttattt tcattgcaat gatgtattta aattatttct      180

gaatatttta ctaaaaaggg aatgtgggag gtcagtgcat ttaaaacata aagaaatgaa      240

gagctagttc aaaccttggg aaaatacact atatcttaaa                            280


<210>  14
<211>  222
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  SV40 late polyA

<400>  14
cagacatgat aagatacatt gatgagtttg gacaaaccac aactagaatg cagtgaaaaa       60

aatgctttat ttgtgaaatt tgtgatgcta ttgctttatt tgtaaccatt ataagctgca      120

ataaacaagt taacaacaac aattgcattc attttatgtt tcaggttcag ggggaggtgt      180

gggaggtttt ttaaagcaag taaaacctct acaaatgtgg ta                         222


<210>  15
<211>  197
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  SV40 promoter

<400>  15
tgcatctcaa ttagtcagca accatagtcc cgcccctaac tccgcccatc ccgcccctaa       60

ctccgcccag ttccgcccat tctccgcccc atcgctgact aatttttttt atttatgcag      120

aggccgaggc cgcctcggcc tctgagctat tccagaagta gtgaggaggc ttttttggag      180

gcctaggctt ttgcaaa                                                     197


<210>  16
<211>  538
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  human CMV immediate-early enhancer/promoter

<400>  16
ggagttccgc gttacataac ttacggtaaa tggcccgcct ggctgaccgc ccaacgaccc       60

ccgcccattg acgtcaataa tgacgtatgt tcccatagta acgccaatag ggactttcca      120

ttgacgtcaa tgggtggagt atttacggta aactgcccac ttggcagtac atcaagtgta      180

tcatatgcca agtacgcccc ctattgacgt caatgacggt aaatggcccg cctggcatta      240

tgcccagtac atgaccttat gggactttcc tacttggcag tacatctacg tattagtcat      300

cgctattacc atggtgatgc ggttttggca gtacatcaat gggcgtggat agcggtttga      360

ctcacgggga tttccaagtc tccaccccat tgacgtcaat gggagtttgt tttggcacca      420

aaatcaacgg gactttccaa aatgtcgtaa caactccgcc ccattgacgc aaatgggcgg      480

taggcgtgta cggtgggagg tctatataag cagagctcgt ttagtgaacc gtcagatc        538


<210>  17
<211>  366
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  TPL

<400>  17
ctcttccgca tcgctgtctg cgagggccag ctgttggggt gagtactccc tctcaaaagc       60

gggcatgact tctgcgctaa gattgtcagt ttccaaaaac gaggaggatt tgatattcac      120

ctggcccgcg gtgatgcctt tgagggtggc cgcgtccatc tggtcagaaa agacaatctt      180

tttgttgtca agcttccttg atgatgtcat acttatcctg tccctttttt ttccacagct      240

cgcggttgag gacaaactct tcgcggtctt tccagtactc ttggatcgga aacccgtcgg      300

cctccgaacg gtactccgcc accgagggac ctgagcgagt ccgcatcgac cggatcggaa      360

aacctc                                                                 366


<210>  18
<211>  528
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Human CMV promoter, derived from GenBank X17403.1

<400>  18
gttacataac ttacggtaaa tggcccgcct ggctgaccgc ccaacgaccc ccgcccattg       60

acgtcaataa tgacgtatgt tcccatagta acgccaatag ggactttcca ttgacgtcaa      120

tgggtggagt atttacggta aactgcccac ttggcagtac atcaagtgta tcatatgcca      180

agtacgcccc ctattgacgt caatgacggt aaatggcccg cctggcatta tgcccagtac      240

atgaccttat gggactttcc tacttggcag tacatctacg tattagtcat cgctattacc      300

atggtgatgc ggttttggca gtacatcaat gggcgtggat agcggtttga ctcacgggga      360

tttccaagtc tccaccccat tgacgtcaat gggagtttgt tttggcacca aaatcaacgg      420

gactttccaa aatgtcgtaa caactccgcc ccattgacgc aaatgggcgg taggcgtgta      480

cggtgggagg tctatataag cagagctcgt ttagtgaacc gtcagatc                   528


<210>  19
<211>  589
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Bacterial replication origin

<400>  19
tttccatagg ctccgccccc ctgacgagca tcacaaaaat cgacgctcaa gtcagaggtg       60

gcgaaacccg acaggactat aaagatacca ggcgtttccc cctggaagct ccctcgtgcg      120

ctctcctgtt ccgaccctgc cgcttaccgg atacctgtcc gcctttctcc cttcgggaag      180

cgtggcgctt tctcatagct cacgctgtag gtatctcagt tcggtgtagg tcgttcgctc      240

caagctgggc tgtgtgcacg aaccccccgt tcagcccgac cgctgcgcct tatccggtaa      300

ctatcgtctt gagtccaacc cggtaagaca cgacttatcg ccactggcag cagccactgg      360

taacaggatt agcagagcga ggtatgtagg cggtgctaca gagttcttga agtggtggcc      420

taactacggc tacactagaa ggacagtatt tggtatctgc gctctgctga agccagttac      480

cttcggaaaa agagttggta gctcttgatc cggcaaacaa accaccgctg gtagcggtgg      540

tttttttgtt tgcaagcagc agattacgcg cagaaaaaaa ggatctcaa                  589


<210>  20
<211>  861
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Ampicillin resistance gene

<400>  20
ttaccaatgc ttaatcagtg aggcacctat ctcagcgatc tgtctatttc gttcatccat       60

agttgcctga ctccccgtcg tgtagataac tacgatacgg gagggcttac catctggccc      120

cagtgctgca atgataccgc gagacccacg ctcaccggct ccagatttat cagcaataaa      180

ccagccagcc ggaagggccg agcgcagaag tggtcctgca actttatccg cctccatcca      240

gtctattaat tgttgccggg aagctagagt aagtagttcg ccagttaata gtttgcgcaa      300

cgttgttgcc attgctacag gcatcgtggt gtcacgctcg tcgtttggta tggcttcatt      360

cagctccggt tcccaacgat caaggcgagt tacatgatcc cccatgttgt gcaaaaaagc      420

ggttagctcc ttcggtcctc cgatcgttgt cagaagtaag ttggccgcag tgttatcact      480

catggttatg gcagcactgc ataattctct tactgtcatg ccatccgtaa gatgcttttc      540

tgtgactggt gagtactcaa ccaagtcatt ctgagaatag tgtatgcggc gaccgagttg      600

ctcttgcccg gcgtcaatac gggataatac cgcgccacat agcagaactt taaaagtgct      660

catcattgga aaacgttctt cggggcgaaa actctcaagg atcttaccgc tgttgagatc      720

cagttcgatg taacccactc gtgcacccaa ctgatcttca gcatctttta ctttcaccag      780

cgtttctggg tgagcaaaaa caggaaggca aaatgccgca aaaaagggaa taagggcgac      840

acggaaatgt tgaatactca t                                                861


<210>  21
<211>  1122
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  GS gene

<400>  21
atggccacct cagcaagttc ccacttgaac aaaaacatca agcaaatgta cttgtgcctg       60

ccccagggtg agaaagtcca agccatgtat atctgggttg atggtactgg agaaggactg      120

cgctgcaaaa cccgcaccct ggactgtgag cccaagtgtg tagaagagtt acctgagtgg      180

aattttgatg gctctagtac ctttcagtct gagggctcca acagtgacat gtatctcagc      240

cctgttgcca tgtttcggga ccccttccgc agagatccca acaagctggt gttctgtgaa      300

gttttcaagt acaaccggaa gcctgcagag accaatttaa ggcactcgtg taaacggata      360

atggacatgg tgagcaacca gcacccctgg tttggaatgg aacaggagta tactctgatg      420

ggaacagatg ggcacccttt tggttggcct tccaatggct ttcctgggcc ccaaggtccg      480

tattactgtg gtgtgggcgc agacaaagcc tatggcaggg atatcgtgga ggctcactac      540

cgcgcctgct tgtatgctgg ggtcaagatt acaggaacaa atgctgaggt catgcctgcc      600

cagtgggagt tccaaatagg accctgtgaa ggaatccgca tgggagatca tctctgggtg      660

gcccgtttca tcttgcatcg agtatgtgaa gactttgggg taatagcaac ctttgacccc      720

aagcccattc ctgggaactg gaatggtgca ggctgccata ccaactttag caccaaggcc      780

atgcgggagg agaatggtct gaagcacatc gaggaggcca tcgagaaact aagcaagcgg      840

caccggtacc acattcgagc ctacgatccc aaggggggcc tggacaatgc ccgtcgtctg      900

actgggttcc acgaaacgtc caacatcaac gacttttctg ctggtgtcgc caatcgcagt      960

gccagcatcc gcattccccg gactgtcggc caggagaaga aaggttactt tgaagaccgc     1020

cgcccctctg ccaattgtga cccctttgca gtgacagaag ccatcgtccg cacatgcctt     1080

ctcaatgaga ctggcgacga gcccttccaa tacaaaaact aa                        1122


<210>  22
<211>  237
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  SV40 enhancer

<400>  22
gctgtggaat gtgtgtcagt tagggtgtgg aaagtcccca ggctccccag caggcagaag       60

tatgcaaagc atgcatctca attagtcagc aaccaggtgt ggaaagtccc caggctcccc      120

agcaggcaga agtatgcaaa gcatgcatct caattagtca gcaaccatag tcccgcccct      180

aactccgccc atcccgcccc taactccgcc cagttccgcc cattctccgc tccatcg         237


<210>  23
<211>  570
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  IRES-4

<400>  23
cccctaacgt tactggccga agccgcttgg aataaggccg gtgtgcgttt gtctatatgt       60

tattttccac catattgccg tcttttggca atgtgagggc ccggaaacct ggccctgtct      120

tcttgacgag cattcctagg ggtctttccc ctctcgccaa aggaatgcaa ggtctgttga      180

atgtcgtgaa ggaagcagtt cctctggaag cttcttgaag acaaacaacg tctgtagcga      240

ccctttgcag gcagcggaac cccccacctg gcgacaggtg cctctgcggc caaaagccac      300

gtgtataaga tacacctgca aaggcggcac aaccccagtg ccacgttgtg agttggatag      360

ttgtggaaag agtcaaatgg ctctcctcaa gcgtattcaa caaggggctg aaggatgccc      420

agaaggtacc ccattgtatg ggatctgatc tggggcctcg gtgcacatgc tttacatgtg      480

tttagtcgag gttaaaaaaa cgtctaggcc ccccgaacca cggggacgtg gttttccttt      540

gaaaaacacg atgataatat ggccacaacc                                       570


<210>  24
<211>  557
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  IRES-5

<400>  24
cccctaacgt tactggccga agccgcttgg aataaggccg gtgtgcgttt gtctatatgt       60

tattttccac catattgccg tcttttggca atgtgagggc ccggaaacct ggccctgtct      120

tcttgacgag cattcctagg ggtctttccc ctctcgccaa aggaatgcaa ggtctgttga      180

atgtcgtgaa ggaagcagtt cctctggaag cttcttgaag acaaacaacg tctgtagcga      240

ccctttgcag gcagcggaac cccccacctg gcgacaggtg cctctgcggc caaaagccac      300

gtgtataaga tacacctgca aaggcggcac aaccccagtg ccacgttgtg agttggatag      360

ttgtggaaag agtcaaatgg ctctcctcaa gcgtattcaa caaggggctg aaggatgccc      420

agaaggtacc ccattgtatg ggatctgatc tggggcctcg gtgcacatgc tttacatgtg      480

tttagtcgag gttaaaaaaa cgtctaggcc ccccgaacca cggggacgtg gttttccttt      540

gaaaaacacg atgataa                                                     557


<210>  25
<211>  550
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  IRES-6

<400>  25
cccctaacgt tactggccga agccgcttgg aataaggccg gtgtgcgttt gtctatatgt       60

tattttccac catattgccg tcttttggca atgtgagggc ccggaaacct ggccctgtct      120

tcttgacgag cattcctagg ggtctttccc ctctcgccaa aggaatgcaa ggtctgttga      180

atgtcgtgaa ggaagcagtt cctctggaag cttcttgaag acaaacaacg tctgtagcga      240

ccctttgcag gcagcggaac cccccacctg gcgacaggtg cctctgcggc caaaagccac      300

gtgtataaga tacacctgca aaggcggcac aaccccagtg ccacgttgtg agttggatag      360

ttgtggaaag agtcaaatgg ctctcctcaa gcgtattcaa caaggggctg aaggatgccc      420

agaaggtacc ccattgtatg ggatctgatc tggggcctcg gtgcacatgc tttacatgtg      480

tttagtcgag gttaaaaaaa cgtctaggcc ccccgaacca cggggacgtg gttttccttt      540

gaaaaacacg                                                             550


<210>  26
<211>  10754
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  pCLD13

<400>  26
ccctagaaag ataatcatat tgtgacgtac gttaaagata atcatgcgta aaattgacgc       60

atgtgtttta tcggtctgta tatcgaggtt tatttattaa tttgaataga tattaagttt      120

tattatattt acacttacat actaataata aattcaacaa acaatttatt tatgtttatt      180

tatttattaa aaaaaaacaa aaactcaaaa tttcttctat aaagtaacaa aacttttatc      240

gaatttgcag cccgggacta gctagaggga cagccccccc ccaaagcccc cagggatgta      300

attacgtccc tcccccgcta gggggcagca gcgagccgcc cggggctccg ctccggtccg      360

gcgctccccc cgcatccccg agccggcagc gtgcggggac agcccgggca cggggaaggt      420

ggcacgggat cgctttcctc tgaacgcttc tcgctgctct ttgagcctgc agacacctgg      480

ggggatacgg ggaaaactta agatccgacc ggacgcgtac tgagagcgct attctgaact      540

tttcttttgt tcccttccct tctaccacac cctaattgta atccatttta atttcctggt      600

cacagtcctg tctctccttc cattgtacct tgcccttttc taaagagcga ctgcaaagta      660

tgtttgcgta ggtgaggatc taaaacttta tgaggtacga acatcacaga attactttgt      720

aatttcagtt tattgtaggc ttggcttttt ggggagggtt tacgtcttag acctcttagt      780

gcttctttgt ttcatggtgt tctaacttcg aagcatctct gtagctttaa tggattcctt      840

ttctgaaagc tttgctctct ttcttccccc tcggctttct cttaggcaag agggctaact      900

gtaaagtaag gcttactgcc ttgtgtttcc aaatgtgtcc gaagaggaag tgtcttctgt      960

gaatcctgtt atgcatgaat aacaggaaat agaaagaaat tcactttcat tattataaaa     1020

gtaatatgtt cgtttaaaaa attctaatga agagctggag atgcaaccca ggggtagagc     1080

acacactcag catgcaggag gccctgggtc caatcttgga atctcctctc agttaacctg     1140

atctctagct gattagtagt gagtgcaagc ccactttcct cttctgcctc attgctcagt     1200

gataacagct gttaaacttt gtcttattct aaaactacct ctgtgcaaat gctagcacaa     1260

taatatatat catatgcaca tgattttttt tttatcttga aaagtaagtc agtatagcta     1320

caaagttcac ttggcattgt caacatttca caggcgtaat attcctcctc tagtactgtc     1380

ctcttcattc tttgtgacca agtttggaga gagtgcacaa atgccaggga ggtttgtggg     1440

aaggtttctc atgttctggt aaggcgagta agaaaatagt ctcatgcagg tgaaatgagt     1500

gctatgcagt atatattata ccagagaaca gcaaatgacc aaattcacac tgaactagtt     1560

cagtaaaatt ggctttgtca aagctttcct tgcttaaaat gtaattccct gtcatcctag     1620

ttctggtctg gattcttttc ctggagtctt gacttccaga ttccctgtgg acttttgttt     1680

gagtttcaag cttttgaaat atagaaacct atctaactta acaaacttgg gagagaaaag     1740

actccagaac aactgaaaac agaccaggct aaatgaatag actttattcc tctcttctta     1800

cctgcagttt tcagatatgc agagttggag cggatcttag aggttgattc attcatgcct     1860

gaagaaaaca cattttatag accctgtgcc caagttcgtg gtggacatca ccctttattt     1920

actaattgca ctacataaca ggcattttag aagactgctc cagtcagaga ccccgcctta     1980

gaggaatctg taaaccctga actcctatca ctcatgagca ctagttatgt ttggaatgcc     2040

gtattaaaac aaaagttaca tttctaaact taaaattttc tagcacagag acagtgggag     2100

tagctaactt tgatagacat ttttctacta aaagtctttc taagtacata atcttctgta     2160

agttggaaaa cagcaaaata gaacgtctcc tacgtagtta atctttttgc ataatttgca     2220

catgtaggag ttattagtat acgggtaagt tttcactttt tcccccaact ggagtgtctt     2280

gtggctgggt ttgaaaaagg gaacgggagg ccgctggagg ggattggtaa atgagataaa     2340

acaccactca ttcaactcag tgactcagca tttaaatttt ccataaaagg attaaaggaa     2400

aattaaacaa attcttaaag ccaagactct ggagaaactt gttggtgtgc tttagttttc     2460

actgttatga ctcatgaatt tatgcataaa ttagtacatt tataaaaaca tagccttttt     2520

agagttttct gtttggctaa agtgccattg ttagcatttg gaattacctt tttatgtctt     2580

atattttttc caaataaaaa taaatgtttc tgctgtctta ctactgaaac tacgttgtga     2640

gcactttaaa tttctcaaag cagtttcgcc tgttatactt ggcgcttagt catcgtcgta     2700

cacaacagga cctgattaag aaggctgtgc tgcctctaag ccgggctaga ttgtagccac     2760

tagcaaccag gctgcaataa tttccctttg atgacatcat ccactgtgga agaacccagt     2820

tgcttcagcc agtcgaacta tacagttcca acctcatcaa atatggcatc tcccttgcct     2880

gctatagcag ggggaggaaa aaatgccacc atctttttaa tctagcaagc ttctcttttc     2940

ttcatctttt tttttttctt ttaaaaaaat tctgatcatg gatgcttctt ccgatcccta     3000

tttgccttat gacgggggag gagacaatat ccccttgagg gaattacata aaagaggtaa     3060

gagcatcccc ttgctctgaa tcctctgttg gttgttgtgc atgcggctgg gcggttctgg     3120

ggacaggctg tctgttgtcc tcttgctgca atgtgctgct tagttgccct gccttgttgc     3180

tgtgggagaa tgcgaccttc ccagcagggc tggccctccc tgattgtttg ctctgtgcag     3240

attagccctg cttcagatca catagggctg cagactccat cttctgtgtg aaaatgcttt     3300

cggtttgatt gcagaaataa gctgccttta cagccagcta aagtcctggt ggttggttgg     3360

cacctgcaaa gtagtatttt tgtacctctg gaaacttata ttttctttac acagcaatat     3420

caagtgccgg tatgccattc tgttttggct gctgccaatt accatgtaga ctttgcacca     3480

cagagtaata gtaaaagctc ctagctgcat tttataacat ttaaaaatag caggaaagaa     3540

gaattatttt tgatttaaca tgtttttgtc atttaacgtc ttaactgatt gacatactat     3600

attgtctgtc tcgtgggtat cttgtacaac ttgataggat aaagcaattt agtttttttt     3660

ttttttttta aatacatcca gaatgtaagt cgtcagtagt tttcgaacag ataagtaatg     3720

gtgttaatct tttggcaggc tttgccttgg tctccttaaa gctaattagg tgttacttaa     3780

ttaaactgct cttttgctca ttttcttaaa ttattttttt aaaagatagt tggcatttgc     3840

tgttctagaa ataaacttca agaaacattc tttagccaga tgacttcatg tatgagccat     3900

gttagtttga attatttgct tggtgttata aactttatgg tttaatacca acttttatta     3960

tgtttacaag gtaaataagg aaaatttcaa gtacattttg tatcctgaga acaaatttaa     4020

gttccataga atttaggaat tacaatgtat tcaacagata cttacttgtc atactgtgcc     4080

tgcaaaacaa taattagact ctgaacaggt gcaacaattt tctgtagaat tagacaagtc     4140

ttcttttggc aggtgttact aagtaggcca tttcccaagg aacagggaat ttgccaggct     4200

tttgtggtgg agagaataga atgaataaat gctgtgggga gtaaagagct tgtcagaaga     4260

tgattagttc tgtggcacca aaaccaagag atcagttttc ctgtgagaag taaaggaagc     4320

attgtagaaa aatagatgtg ttgaagtcta ccggtggagt tccgcgttac ataacttacg     4380

gtaaatggcc cgcctggctg accgcccaac gacccccgcc cattgacgtc aataatgacg     4440

tatgttccca tagtaacgcc aatagggact ttccattgac gtcaatgggt ggagtattta     4500

cggtaaactg cccacttggc agtacatcaa gtgtatcata tgccaagtac gccccctatt     4560

gacgtcaatg acggtaaatg gcccgcctgg cattatgccc agtacatgac cttatgggac     4620

tttcctactt ggcagtacat ctacgtatta gtcatcgcta ttaccattgt gatgcggttt     4680

tggcagtaca tcaatgggcg tggatagcgg tttgactcac ggggatttcc aagtctccac     4740

cccattgacg tcaatgggag tttgttttgg caccaaaatc aacgggactt tccaaaatgt     4800

cgtaacaact ccgccccatt gacgcaaatg ggcggtaggc gtgtacggtg ggaggtctat     4860

ataagcagag ctcgtttagt gaaccgtcag atctacctct tccgcatcgc tgtctgcgag     4920

ggccagctgt tggggtgagt actccctctc aaaagcgggc atgacttctg cgctaagatt     4980

gtcagtttcc aaaaacgagg aggatttgat attcacctgg cccgcggtga tgcctttgag     5040

ggtggccgcg tccatctggt cagaaaagac aatctttttg ttgtcaagct tccttgatga     5100

tgtcatactt atcctgtccc ttttttttcc acagctcgcg gttgaggaca aactcttcgc     5160

ggtctttcca gtactcttgg atcggaaacc cgtcggcctc cgaacggtac tccgccaccg     5220

agggacctga gcgagtccgc atcgaccgga tcggaaaacc tcggatccga attcatagat     5280

aactgatcca gtgcccctaa cgttactggc cgaagccgct tggaataagg ccggtgtgcg     5340

tttgtctata tgttattttc caccatattg ccgtcttttg gcaatgtgag ggcccggaaa     5400

cctggccctg tcttcttgac gagcattcct aggggtcttt cccctctcgc caaaggaatg     5460

caaggtctgt tgaatgtcgt gaaggaagca gttcctctgg aagcttcttg aagacaaaca     5520

acgtctgtag cgaccctttg caggcagcgg aaccccccac ctggcgacag gtgcctctgc     5580

ggccaaaagc cacgtgtata agatacacct gcaaaggcgg cacaacccca gtgccacgtt     5640

gtgagttgga tagttgtgga aagagtcaaa tggctctcct caagcgtatt caacaagggg     5700

ctgaaggatg cccagaaggt accccattgt atgggatctg atctggggcc tcggtgcaca     5760

tgctttacat gtgtttagtc gaggttaaaa aacgtctagg ccccccgaac cacggggacg     5820

tggttttcct ttgaaaaaca cgatgataaa tggccacctc agcaagttcc cacttgaaca     5880

aaaacatcaa gcaaatgtac ttgtgcctgc cccagggtga gaaagtccaa gccatgtata     5940

tctgggttga tggtactgga gaaggactgc gctgcaaaac ccgcaccctg gactgtgagc     6000

ccaagtgtgt agaagagtta cctgagtgga attttgatgg ctctagtacc tttcagtctg     6060

agggctccaa cagtgacatg tatctcagcc ctgttgccat gtttcgggac cccttccgca     6120

gagatcccaa caagctggtg ttctgtgaag ttttcaagta caaccggaag cctgcagaga     6180

ccaatttaag gcactcgtgt aaacggataa tggacatggt gagcaaccag cacccctggt     6240

ttggaatgga acaggagtat actctgatgg gaacagatgg gcaccctttt ggttggcctt     6300

ccaatggctt tcctgggccc caaggtccgt attactgtgg tgtgggcgca gacaaagcct     6360

atggcaggga tatcgtggag gctcactacc gcgcctgctt gtatgctggg gtcaagatta     6420

caggaacaaa tgctgaggtc atgcctgccc agtgggagtt ccaaatagga ccctgtgaag     6480

gaatccgcat gggagatcat ctctgggtgg cccgtttcat cttgcatcga gtatgtgaag     6540

actttggggt aatagcaacc tttgacccca agcccattcc tgggaactgg aatggtgcag     6600

gctgccatac caactttagc accaaggcca tgcgggagga gaatggtctg aagcacatcg     6660

aggaggccat cgagaaacta agcaagcggc accggtacca cattcgagcc tacgatccca     6720

aggggggcct ggacaatgcc cgtcgtctga ctgggttcca cgaaacgtcc aacatcaacg     6780

acttttctgc tggtgtcgcc aatcgcagtg ccagcatccg cattccccgg actgtcggcc     6840

aggagaagaa aggttacttt gaagaccgcc gcccctctgc caattgtgac ccctttgcag     6900

tgacagaagc catcgtccgc acatgccttc tcaatgagac tggcgacgag cccttccaat     6960

acaaaaacta atctagatcc ccctcgcttt cttgctgtcc aatttctatt aaaggttcct     7020

ttgttcccta agtccaacta ctaaactggg ggatattatg aagggccttg agcatctgga     7080

ttctgcctaa taaaaaacat ttattttcat tgcaatgatg tatttaaatt atttctgaat     7140

attttactaa aaagggaatg tgggaggtca gtgcatttaa aacataaaga aatgaagagg     7200

gggatcttcg cgatactgca tcgatgaggg acagcccccc cccaaagccc ccagggatgt     7260

aattacgtcc ctcccccgct agggggcagc agcgagccgc ccggggctcc gctccggtcc     7320

ggcgctcccc ccgcatcccc gagccggcag cgtgcgggga cagcccgggc acggggaagg     7380

tggcacggga tcgctttcct ctgaacgctt ctcgctgctc tttgagcctg cagacacctg     7440

gggggatacg gggaaaatag acaccgcggt ggagctccag cttttgttcc ctttagtgag     7500

ggttaattag ttcttaatac gactcactat agggcgaatt ggctaccggg ccgcccatcg     7560

agggtatcat aagcttatat ctataacaag aaaatatata tataataagt tatcacgtaa     7620

gtagaacatg aaataacaat ataattatcg tatgagttaa atcttaaaag tcacgtaaaa     7680

gataatcatg cgtcattttg actcacgcgg tcgttatagt tcaaaatcag tgacacttac     7740

cgcattgaca agcacgcctc acgggagctc caagcggcga ctgagatgtc ctaaatgcac     7800

agcgacggat tcgcgctatt tagaaagaga gagcaatatt tcaagaatgc atgcgtcaat     7860

tttacgcaga ctatctttct agggttaaat cgatagatgc gatcctgcag gtctccctat     7920

agtgagtcgt attaatttcg ataagccagc tgcattaatg aatcggccaa cgcgcgggga     7980

gaggcggttt gcgtattggg cgctcttccg cttcctcgct cactgactcg ctgcgctcgg     8040

tcgttcggct gcggcgagcg gtatcagctc actcaaaggc ggtaatacgg ttatccacag     8100

aatcagggga taacgcagga aagaacatgt gagcaaaagg ccagcaaaag gccaggaacc     8160

gtaaaaaggc cgcgttgctg gcgtttttcc ataggctccg cccccctgac gagcatcaca     8220

aaaatcgacg ctcaagtcag aggtggcgaa acccgacagg actataaaga taccaggcgt     8280

ttccccctgg aagctccctc gtgcgctctc ctgttccgac cctgccgctt accggatacc     8340

tgtccgcctt tctcccttcg ggaagcgtgg cgctttctca tagctcacgc tgtaggtatc     8400

tcagttcggt gtaggtcgtt cgctccaagc tgggctgtgt gcacgaaccc cccgttcagc     8460

ccgaccgctg cgccttatcc ggtaactatc gtcttgagtc caacccggta agacacgact     8520

tatcgccact ggcagcagcc actggtaaca ggattagcag agcgaggtat gtaggcggtg     8580

ctacagagtt cttgaagtgg tggcctaact acggctacac tagaaggaca gtatttggta     8640

tctgcgctct gctgaagcca gttaccttcg gaaaaagagt tggtagctct tgatccggca     8700

aacaaaccac cgctggtagc ggtggttttt ttgtttgcaa gcagcagatt acgcgcagaa     8760

aaaaaggatc tcaagaagat cctttgatct tttctacggg gtctgacgct cagtggaacg     8820

aaaactcacg ttaagggatt ttggtcatga gattatcaaa aaggatcttc acctagatcc     8880

ttttaaatta aaaatgaagt tttaaatcaa tctaaagtat atatgagtaa acttggtctg     8940

acagttacca atgcttaatc agtgaggcac ctatctcagc gatctgtcta tttcgttcat     9000

ccatagttgc ctgactcccc gtcgtgtaga taactacgat acgggagggc ttaccatctg     9060

gccccagtgc tgcaatgata ccgcgagacc cacgctcacc ggctccagat ttatcagcaa     9120

taaaccagcc agccggaagg gccgagcgca gaagtggtcc tgcaacttta tccgcctcca     9180

tccagtctat taattgttgc cgggaagcta gagtaagtag ttcgccagtt aatagtttgc     9240

gcaacgttgt tgccattgct acaggcatcg tggtgtcacg ctcgtcgttt ggtatggctt     9300

cattcagctc cggttcccaa cgatcaaggc gagttacatg atcccccatg ttgtgcaaaa     9360

aagcggttag ctccttcggt cctccgatcg ttgtcagaag taagttggcc gcagtgttat     9420

cactcatggt tatggcagca ctgcataatt ctcttactgt catgccatcc gtaagatgct     9480

tttctgtgac tggtgagtac tcaaccaagt cattctgaga atagtgtatg cggcgaccga     9540

gttgctcttg cccggcgtca atacgggata ataccgcgcc acatagcaga actttaaaag     9600

tgctcatcat tggaaaacgt tcttcggggc gaaaactctc aaggatctta ccgctgttga     9660

gatccagttc gatgtaaccc actcgtgcac ccaactgatc ttcagcatct tttactttca     9720

ccagcgtttc tgggtgagca aaaacaggaa ggcaaaatgc cgcaaaaaag ggaataaggg     9780

cgacacggaa atgttgaata ctcatactct tcctttttca atattattga agcatttatc     9840

agggttattg tctcatgagc ggatacatat ttgaatgtat ttagaaaaat aaacaaatag     9900

gggttccgcg cacatttccc cgaaaagtgc cacctgacgt ctaagaaacc attattatca     9960

tgacattaac ctataaaaat aggcgtatca cgaggccctt tcgtctcgcg cgtttcggtg    10020

atgacggtga aaacctctga cacatgcagc tcccggagac ggtcacagct tgtctgtaag    10080

cggatgccgg gagcagacaa gcccgtcagg gcgcgtcagc gggtgttggc gggtgtcggg    10140

gctggcttaa ctatgcggca tcagagcaga ttgtactgag agtgcaccat atcgacgctc    10200

tcccttatgc gactcctgca ttaggaagca gcccagtagt aggttgaggc cgttgagcac    10260

cgccgccgca aggaatggtg catgcaagga gatggcgccc aacagtcccc cggccacggg    10320

gcctgccacc atacccacgc cgaaacaagc gctcatgagc ccgaagtggc gagcccgatc    10380

ttccccatcg gtgatgtcgg cgatataggc gccagcaacc gcacctgtgg cgccggtgat    10440

gccggccacg atgcgtccgg cgtagaggat ctggctagcg atgaccctgc tgattggttc    10500

gctgaccatt tccggggtgc ggaacggcgt taccagaaac tcagaaggtt cgtccaacca    10560

aaccgactct gacggcagtt tacgagagag atgatagggt ctgcttcagt aagccagatg    10620

ctacacaatt aggcttgtac atattgtcgt tagaacgcgg ctacaattaa tacataacct    10680

tatgtatcat acacatacga tttaggtgac actatagaat acacctgcag gacgtcccaa    10740

tgatcttaag ttaa                                                      10754


<210>  27
<211>  10768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  pCLD15

<400>  27
ccctagaaag ataatcatat tgtgacgtac gttaaagata atcatgcgta aaattgacgc       60

atgtgtttta tcggtctgta tatcgaggtt tatttattaa tttgaataga tattaagttt      120

tattatattt acacttacat actaataata aattcaacaa acaatttatt tatgtttatt      180

tatttattaa aaaaaaacaa aaactcaaaa tttcttctat aaagtaacaa aacttttatc      240

gaatttgcag cccgggacta gctagaggga cagccccccc ccaaagcccc cagggatgta      300

attacgtccc tcccccgcta gggggcagca gcgagccgcc cggggctccg ctccggtccg      360

gcgctccccc cgcatccccg agccggcagc gtgcggggac agcccgggca cggggaaggt      420

ggcacgggat cgctttcctc tgaacgcttc tcgctgctct ttgagcctgc agacacctgg      480

ggggatacgg ggaaaactta agatccgacc ggacgcgtac tgagagcgct attctgaact      540

tttcttttgt tcccttccct tctaccacac cctaattgta atccatttta atttcctggt      600

cacagtcctg tctctccttc cattgtacct tgcccttttc taaagagcga ctgcaaagta      660

tgtttgcgta ggtgaggatc taaaacttta tgaggtacga acatcacaga attactttgt      720

aatttcagtt tattgtaggc ttggcttttt ggggagggtt tacgtcttag acctcttagt      780

gcttctttgt ttcatggtgt tctaacttcg aagcatctct gtagctttaa tggattcctt      840

ttctgaaagc tttgctctct ttcttccccc tcggctttct cttaggcaag agggctaact      900

gtaaagtaag gcttactgcc ttgtgtttcc aaatgtgtcc gaagaggaag tgtcttctgt      960

gaatcctgtt atgcatgaat aacaggaaat agaaagaaat tcactttcat tattataaaa     1020

gtaatatgtt cgtttaaaaa attctaatga agagctggag atgcaaccca ggggtagagc     1080

acacactcag catgcaggag gccctgggtc caatcttgga atctcctctc agttaacctg     1140

atctctagct gattagtagt gagtgcaagc ccactttcct cttctgcctc attgctcagt     1200

gataacagct gttaaacttt gtcttattct aaaactacct ctgtgcaaat gctagcacaa     1260

taatatatat catatgcaca tgattttttt tttatcttga aaagtaagtc agtatagcta     1320

caaagttcac ttggcattgt caacatttca caggcgtaat attcctcctc tagtactgtc     1380

ctcttcattc tttgtgacca agtttggaga gagtgcacaa atgccaggga ggtttgtggg     1440

aaggtttctc atgttctggt aaggcgagta agaaaatagt ctcatgcagg tgaaatgagt     1500

gctatgcagt atatattata ccagagaaca gcaaatgacc aaattcacac tgaactagtt     1560

cagtaaaatt ggctttgtca aagctttcct tgcttaaaat gtaattccct gtcatcctag     1620

ttctggtctg gattcttttc ctggagtctt gacttccaga ttccctgtgg acttttgttt     1680

gagtttcaag cttttgaaat atagaaacct atctaactta acaaacttgg gagagaaaag     1740

actccagaac aactgaaaac agaccaggct aaatgaatag actttattcc tctcttctta     1800

cctgcagttt tcagatatgc agagttggag cggatcttag aggttgattc attcatgcct     1860

gaagaaaaca cattttatag accctgtgcc caagttcgtg gtggacatca ccctttattt     1920

actaattgca ctacataaca ggcattttag aagactgctc cagtcagaga ccccgcctta     1980

gaggaatctg taaaccctga actcctatca ctcatgagca ctagttatgt ttggaatgcc     2040

gtattaaaac aaaagttaca tttctaaact taaaattttc tagcacagag acagtgggag     2100

tagctaactt tgatagacat ttttctacta aaagtctttc taagtacata atcttctgta     2160

agttggaaaa cagcaaaata gaacgtctcc tacgtagtta atctttttgc ataatttgca     2220

catgtaggag ttattagtat acgggtaagt tttcactttt tcccccaact ggagtgtctt     2280

gtggctgggt ttgaaaaagg gaacgggagg ccgctggagg ggattggtaa atgagataaa     2340

acaccactca ttcaactcag tgactcagca tttaaatttt ccataaaagg attaaaggaa     2400

aattaaacaa attcttaaag ccaagactct ggagaaactt gttggtgtgc tttagttttc     2460

actgttatga ctcatgaatt tatgcataaa ttagtacatt tataaaaaca tagccttttt     2520

agagttttct gtttggctaa agtgccattg ttagcatttg gaattacctt tttatgtctt     2580

atattttttc caaataaaaa taaatgtttc tgctgtctta ctactgaaac tacgttgtga     2640

gcactttaaa tttctcaaag cagtttcgcc tgttatactt ggcgcttagt catcgtcgta     2700

cacaacagga cctgattaag aaggctgtgc tgcctctaag ccgggctaga ttgtagccac     2760

tagcaaccag gctgcaataa tttccctttg atgacatcat ccactgtgga agaacccagt     2820

tgcttcagcc agtcgaacta tacagttcca acctcatcaa atatggcatc tcccttgcct     2880

gctatagcag ggggaggaaa aaatgccacc atctttttaa tctagcaagc ttctcttttc     2940

ttcatctttt tttttttctt ttaaaaaaat tctgatcatg gatgcttctt ccgatcccta     3000

tttgccttat gacgggggag gagacaatat ccccttgagg gaattacata aaagaggtaa     3060

gagcatcccc ttgctctgaa tcctctgttg gttgttgtgc atgcggctgg gcggttctgg     3120

ggacaggctg tctgttgtcc tcttgctgca atgtgctgct tagttgccct gccttgttgc     3180

tgtgggagaa tgcgaccttc ccagcagggc tggccctccc tgattgtttg ctctgtgcag     3240

attagccctg cttcagatca catagggctg cagactccat cttctgtgtg aaaatgcttt     3300

cggtttgatt gcagaaataa gctgccttta cagccagcta aagtcctggt ggttggttgg     3360

cacctgcaaa gtagtatttt tgtacctctg gaaacttata ttttctttac acagcaatat     3420

caagtgccgg tatgccattc tgttttggct gctgccaatt accatgtaga ctttgcacca     3480

cagagtaata gtaaaagctc ctagctgcat tttataacat ttaaaaatag caggaaagaa     3540

gaattatttt tgatttaaca tgtttttgtc atttaacgtc ttaactgatt gacatactat     3600

attgtctgtc tcgtgggtat cttgtacaac ttgataggat aaagcaattt agtttttttt     3660

ttttttttta aatacatcca gaatgtaagt cgtcagtagt tttcgaacag ataagtaatg     3720

gtgttaatct tttggcaggc tttgccttgg tctccttaaa gctaattagg tgttacttaa     3780

ttaaactgct cttttgctca ttttcttaaa ttattttttt aaaagatagt tggcatttgc     3840

tgttctagaa ataaacttca agaaacattc tttagccaga tgacttcatg tatgagccat     3900

gttagtttga attatttgct tggtgttata aactttatgg tttaatacca acttttatta     3960

tgtttacaag gtaaataagg aaaatttcaa gtacattttg tatcctgaga acaaatttaa     4020

gttccataga atttaggaat tacaatgtat tcaacagata cttacttgtc atactgtgcc     4080

tgcaaaacaa taattagact ctgaacaggt gcaacaattt tctgtagaat tagacaagtc     4140

ttcttttggc aggtgttact aagtaggcca tttcccaagg aacagggaat ttgccaggct     4200

tttgtggtgg agagaataga atgaataaat gctgtgggga gtaaagagct tgtcagaaga     4260

tgattagttc tgtggcacca aaaccaagag atcagttttc ctgtgagaag taaaggaagc     4320

attgtagaaa aatagatgtg ttgaagtcta ccggtggagt tccgcgttac ataacttacg     4380

gtaaatggcc cgcctggctg accgcccaac gacccccgcc cattgacgtc aataatgacg     4440

tatgttccca tagtaacgcc aatagggact ttccattgac gtcaatgggt ggagtattta     4500

cggtaaactg cccacttggc agtacatcaa gtgtatcata tgccaagtac gccccctatt     4560

gacgtcaatg acggtaaatg gcccgcctgg cattatgccc agtacatgac cttatgggac     4620

tttcctactt ggcagtacat ctacgtatta gtcatcgcta ttaccattgt gatgcggttt     4680

tggcagtaca tcaatgggcg tggatagcgg tttgactcac ggggatttcc aagtctccac     4740

cccattgacg tcaatgggag tttgttttgg caccaaaatc aacgggactt tccaaaatgt     4800

cgtaacaact ccgccccatt gacgcaaatg ggcggtaggc gtgtacggtg ggaggtctat     4860

ataagcagag ctcgtttagt gaaccgtcag atctacctct tccgcatcgc tgtctgcgag     4920

ggccagctgt tggggtgagt actccctctc aaaagcgggc atgacttctg cgctaagatt     4980

gtcagtttcc aaaaacgagg aggatttgat attcacctgg cccgcggtga tgcctttgag     5040

ggtggccgcg tccatctggt cagaaaagac aatctttttg ttgtcaagct tccttgatga     5100

tgtcatactt atcctgtccc ttttttttcc acagctcgcg gttgaggaca aactcttcgc     5160

ggtctttcca gtactcttgg atcggaaacc cgtcggcctc cgaacggtac tccgccaccg     5220

agggacctga gcgagtccgc atcgaccgga tcggaaaacc tcggatccga attcatagat     5280

aactgatcca gtgcccctaa cgttactggc cgaagccgct tggaataagg ccggtgtgcg     5340

tttgtctata tgttattttc caccatattg ccgtcttttg gcaatgtgag ggcccggaaa     5400

cctggccctg tcttcttgac gagcattcct aggggtcttt cccctctcgc caaaggaatg     5460

caaggtctgt tgaatgtcgt gaaggaagca gttcctctgg aagcttcttg aagacaaaca     5520

acgtctgtag cgaccctttg caggcagcgg aaccccccac ctggcgacag gtgcctctgc     5580

ggccaaaagc cacgtgtata agatacacct gcaaaggcgg cacaacccca gtgccacgtt     5640

gtgagttgga tagttgtgga aagagtcaaa tggctctcct caagcgtatt caacaagggg     5700

ctgaaggatg cccagaaggt accccattgt atgggatctg atctggggcc tcggtgcaca     5760

tgctttacat gtgtttagtc gaggttaaaa aaacgtctag gccccccgaa ccacggggac     5820

gtggttttcc tttgaaaaac acgatgataa tatggccaca accatggcca cctcagcaag     5880

ttcccacttg aacaaaaaca tcaagcaaat gtacttgtgc ctgccccagg gtgagaaagt     5940

ccaagccatg tatatctggg ttgatggtac tggagaagga ctgcgctgca aaacccgcac     6000

cctggactgt gagcccaagt gtgtagaaga gttacctgag tggaattttg atggctctag     6060

tacctttcag tctgagggct ccaacagtga catgtatctc agccctgttg ccatgtttcg     6120

ggaccccttc cgcagagatc ccaacaagct ggtgttctgt gaagttttca agtacaaccg     6180

gaagcctgca gagaccaatt taaggcactc gtgtaaacgg ataatggaca tggtgagcaa     6240

ccagcacccc tggtttggaa tggaacagga gtatactctg atgggaacag atgggcaccc     6300

ttttggttgg ccttccaatg gctttcctgg gccccaaggt ccgtattact gtggtgtggg     6360

cgcagacaaa gcctatggca gggatatcgt ggaggctcac taccgcgcct gcttgtatgc     6420

tggggtcaag attacaggaa caaatgctga ggtcatgcct gcccagtggg agttccaaat     6480

aggaccctgt gaaggaatcc gcatgggaga tcatctctgg gtggcccgtt tcatcttgca     6540

tcgagtatgt gaagactttg gggtaatagc aacctttgac cccaagccca ttcctgggaa     6600

ctggaatggt gcaggctgcc ataccaactt tagcaccaag gccatgcggg aggagaatgg     6660

tctgaagcac atcgaggagg ccatcgagaa actaagcaag cggcaccggt accacattcg     6720

agcctacgat cccaaggggg gcctggacaa tgcccgtcgt ctgactgggt tccacgaaac     6780

gtccaacatc aacgactttt ctgctggtgt cgccaatcgc agtgccagca tccgcattcc     6840

ccggactgtc ggccaggaga agaaaggtta ctttgaagac cgccgcccct ctgccaattg     6900

tgaccccttt gcagtgacag aagccatcgt ccgcacatgc cttctcaatg agactggcga     6960

cgagcccttc caatacaaaa actaatctag atccccctcg ctttcttgct gtccaatttc     7020

tattaaaggt tcctttgttc cctaagtcca actactaaac tgggggatat tatgaagggc     7080

cttgagcatc tggattctgc ctaataaaaa acatttattt tcattgcaat gatgtattta     7140

aattatttct gaatatttta ctaaaaaggg aatgtgggag gtcagtgcat ttaaaacata     7200

aagaaatgaa gagggggatc ttcgcgatac tgcatcgatg agggacagcc cccccccaaa     7260

gcccccaggg atgtaattac gtccctcccc cgctaggggg cagcagcgag ccgcccgggg     7320

ctccgctccg gtccggcgct ccccccgcat ccccgagccg gcagcgtgcg gggacagccc     7380

gggcacgggg aaggtggcac gggatcgctt tcctctgaac gcttctcgct gctctttgag     7440

cctgcagaca cctgggggga tacggggaaa atagacaccg cggtggagct ccagcttttg     7500

ttccctttag tgagggttaa ttagttctta atacgactca ctatagggcg aattggctac     7560

cgggccgccc atcgagggta tcataagctt atatctataa caagaaaata tatatataat     7620

aagttatcac gtaagtagaa catgaaataa caatataatt atcgtatgag ttaaatctta     7680

aaagtcacgt aaaagataat catgcgtcat tttgactcac gcggtcgtta tagttcaaaa     7740

tcagtgacac ttaccgcatt gacaagcacg cctcacggga gctccaagcg gcgactgaga     7800

tgtcctaaat gcacagcgac ggattcgcgc tatttagaaa gagagagcaa tatttcaaga     7860

atgcatgcgt caattttacg cagactatct ttctagggtt aaatcgatag atgcgatcct     7920

gcaggtctcc ctatagtgag tcgtattaat ttcgataagc cagctgcatt aatgaatcgg     7980

ccaacgcgcg gggagaggcg gtttgcgtat tgggcgctct tccgcttcct cgctcactga     8040

ctcgctgcgc tcggtcgttc ggctgcggcg agcggtatca gctcactcaa aggcggtaat     8100

acggttatcc acagaatcag gggataacgc aggaaagaac atgtgagcaa aaggccagca     8160

aaaggccagg aaccgtaaaa aggccgcgtt gctggcgttt ttccataggc tccgcccccc     8220

tgacgagcat cacaaaaatc gacgctcaag tcagaggtgg cgaaacccga caggactata     8280

aagataccag gcgtttcccc ctggaagctc cctcgtgcgc tctcctgttc cgaccctgcc     8340

gcttaccgga tacctgtccg cctttctccc ttcgggaagc gtggcgcttt ctcatagctc     8400

acgctgtagg tatctcagtt cggtgtaggt cgttcgctcc aagctgggct gtgtgcacga     8460

accccccgtt cagcccgacc gctgcgcctt atccggtaac tatcgtcttg agtccaaccc     8520

ggtaagacac gacttatcgc cactggcagc agccactggt aacaggatta gcagagcgag     8580

gtatgtaggc ggtgctacag agttcttgaa gtggtggcct aactacggct acactagaag     8640

gacagtattt ggtatctgcg ctctgctgaa gccagttacc ttcggaaaaa gagttggtag     8700

ctcttgatcc ggcaaacaaa ccaccgctgg tagcggtggt ttttttgttt gcaagcagca     8760

gattacgcgc agaaaaaaag gatctcaaga agatcctttg atcttttcta cggggtctga     8820

cgctcagtgg aacgaaaact cacgttaagg gattttggtc atgagattat caaaaaggat     8880

cttcacctag atccttttaa attaaaaatg aagttttaaa tcaatctaaa gtatatatga     8940

gtaaacttgg tctgacagtt accaatgctt aatcagtgag gcacctatct cagcgatctg     9000

tctatttcgt tcatccatag ttgcctgact ccccgtcgtg tagataacta cgatacggga     9060

gggcttacca tctggcccca gtgctgcaat gataccgcga gacccacgct caccggctcc     9120

agatttatca gcaataaacc agccagccgg aagggccgag cgcagaagtg gtcctgcaac     9180

tttatccgcc tccatccagt ctattaattg ttgccgggaa gctagagtaa gtagttcgcc     9240

agttaatagt ttgcgcaacg ttgttgccat tgctacaggc atcgtggtgt cacgctcgtc     9300

gtttggtatg gcttcattca gctccggttc ccaacgatca aggcgagtta catgatcccc     9360

catgttgtgc aaaaaagcgg ttagctcctt cggtcctccg atcgttgtca gaagtaagtt     9420

ggccgcagtg ttatcactca tggttatggc agcactgcat aattctctta ctgtcatgcc     9480

atccgtaaga tgcttttctg tgactggtga gtactcaacc aagtcattct gagaatagtg     9540

tatgcggcga ccgagttgct cttgcccggc gtcaatacgg gataataccg cgccacatag     9600

cagaacttta aaagtgctca tcattggaaa acgttcttcg gggcgaaaac tctcaaggat     9660

cttaccgctg ttgagatcca gttcgatgta acccactcgt gcacccaact gatcttcagc     9720

atcttttact ttcaccagcg tttctgggtg agcaaaaaca ggaaggcaaa atgccgcaaa     9780

aaagggaata agggcgacac ggaaatgttg aatactcata ctcttccttt ttcaatatta     9840

ttgaagcatt tatcagggtt attgtctcat gagcggatac atatttgaat gtatttagaa     9900

aaataaacaa ataggggttc cgcgcacatt tccccgaaaa gtgccacctg acgtctaaga     9960

aaccattatt atcatgacat taacctataa aaataggcgt atcacgaggc cctttcgtct    10020

cgcgcgtttc ggtgatgacg gtgaaaacct ctgacacatg cagctcccgg agacggtcac    10080

agcttgtctg taagcggatg ccgggagcag acaagcccgt cagggcgcgt cagcgggtgt    10140

tggcgggtgt cggggctggc ttaactatgc ggcatcagag cagattgtac tgagagtgca    10200

ccatatcgac gctctccctt atgcgactcc tgcattagga agcagcccag tagtaggttg    10260

aggccgttga gcaccgccgc cgcaaggaat ggtgcatgca aggagatggc gcccaacagt    10320

cccccggcca cggggcctgc caccataccc acgccgaaac aagcgctcat gagcccgaag    10380

tggcgagccc gatcttcccc atcggtgatg tcggcgatat aggcgccagc aaccgcacct    10440

gtggcgccgg tgatgccggc cacgatgcgt ccggcgtaga ggatctggct agcgatgacc    10500

ctgctgattg gttcgctgac catttccggg gtgcggaacg gcgttaccag aaactcagaa    10560

ggttcgtcca accaaaccga ctctgacggc agtttacgag agagatgata gggtctgctt    10620

cagtaagcca gatgctacac aattaggctt gtacatattg tcgttagaac gcggctacaa    10680

ttaatacata accttatgta tcatacacat acgatttagg tgacactata gaatacacct    10740

gcaggacgtc ccaatgatct taagttaa                                       10768


<210>  28
<211>  10755
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  pCLD16

<400>  28
ccctagaaag ataatcatat tgtgacgtac gttaaagata atcatgcgta aaattgacgc       60

atgtgtttta tcggtctgta tatcgaggtt tatttattaa tttgaataga tattaagttt      120

tattatattt acacttacat actaataata aattcaacaa acaatttatt tatgtttatt      180

tatttattaa aaaaaaacaa aaactcaaaa tttcttctat aaagtaacaa aacttttatc      240

gaatttgcag cccgggacta gctagaggga cagccccccc ccaaagcccc cagggatgta      300

attacgtccc tcccccgcta gggggcagca gcgagccgcc cggggctccg ctccggtccg      360

gcgctccccc cgcatccccg agccggcagc gtgcggggac agcccgggca cggggaaggt      420

ggcacgggat cgctttcctc tgaacgcttc tcgctgctct ttgagcctgc agacacctgg      480

ggggatacgg ggaaaactta agatccgacc ggacgcgtac tgagagcgct attctgaact      540

tttcttttgt tcccttccct tctaccacac cctaattgta atccatttta atttcctggt      600

cacagtcctg tctctccttc cattgtacct tgcccttttc taaagagcga ctgcaaagta      660

tgtttgcgta ggtgaggatc taaaacttta tgaggtacga acatcacaga attactttgt      720

aatttcagtt tattgtaggc ttggcttttt ggggagggtt tacgtcttag acctcttagt      780

gcttctttgt ttcatggtgt tctaacttcg aagcatctct gtagctttaa tggattcctt      840

ttctgaaagc tttgctctct ttcttccccc tcggctttct cttaggcaag agggctaact      900

gtaaagtaag gcttactgcc ttgtgtttcc aaatgtgtcc gaagaggaag tgtcttctgt      960

gaatcctgtt atgcatgaat aacaggaaat agaaagaaat tcactttcat tattataaaa     1020

gtaatatgtt cgtttaaaaa attctaatga agagctggag atgcaaccca ggggtagagc     1080

acacactcag catgcaggag gccctgggtc caatcttgga atctcctctc agttaacctg     1140

atctctagct gattagtagt gagtgcaagc ccactttcct cttctgcctc attgctcagt     1200

gataacagct gttaaacttt gtcttattct aaaactacct ctgtgcaaat gctagcacaa     1260

taatatatat catatgcaca tgattttttt tttatcttga aaagtaagtc agtatagcta     1320

caaagttcac ttggcattgt caacatttca caggcgtaat attcctcctc tagtactgtc     1380

ctcttcattc tttgtgacca agtttggaga gagtgcacaa atgccaggga ggtttgtggg     1440

aaggtttctc atgttctggt aaggcgagta agaaaatagt ctcatgcagg tgaaatgagt     1500

gctatgcagt atatattata ccagagaaca gcaaatgacc aaattcacac tgaactagtt     1560

cagtaaaatt ggctttgtca aagctttcct tgcttaaaat gtaattccct gtcatcctag     1620

ttctggtctg gattcttttc ctggagtctt gacttccaga ttccctgtgg acttttgttt     1680

gagtttcaag cttttgaaat atagaaacct atctaactta acaaacttgg gagagaaaag     1740

actccagaac aactgaaaac agaccaggct aaatgaatag actttattcc tctcttctta     1800

cctgcagttt tcagatatgc agagttggag cggatcttag aggttgattc attcatgcct     1860

gaagaaaaca cattttatag accctgtgcc caagttcgtg gtggacatca ccctttattt     1920

actaattgca ctacataaca ggcattttag aagactgctc cagtcagaga ccccgcctta     1980

gaggaatctg taaaccctga actcctatca ctcatgagca ctagttatgt ttggaatgcc     2040

gtattaaaac aaaagttaca tttctaaact taaaattttc tagcacagag acagtgggag     2100

tagctaactt tgatagacat ttttctacta aaagtctttc taagtacata atcttctgta     2160

agttggaaaa cagcaaaata gaacgtctcc tacgtagtta atctttttgc ataatttgca     2220

catgtaggag ttattagtat acgggtaagt tttcactttt tcccccaact ggagtgtctt     2280

gtggctgggt ttgaaaaagg gaacgggagg ccgctggagg ggattggtaa atgagataaa     2340

acaccactca ttcaactcag tgactcagca tttaaatttt ccataaaagg attaaaggaa     2400

aattaaacaa attcttaaag ccaagactct ggagaaactt gttggtgtgc tttagttttc     2460

actgttatga ctcatgaatt tatgcataaa ttagtacatt tataaaaaca tagccttttt     2520

agagttttct gtttggctaa agtgccattg ttagcatttg gaattacctt tttatgtctt     2580

atattttttc caaataaaaa taaatgtttc tgctgtctta ctactgaaac tacgttgtga     2640

gcactttaaa tttctcaaag cagtttcgcc tgttatactt ggcgcttagt catcgtcgta     2700

cacaacagga cctgattaag aaggctgtgc tgcctctaag ccgggctaga ttgtagccac     2760

tagcaaccag gctgcaataa tttccctttg atgacatcat ccactgtgga agaacccagt     2820

tgcttcagcc agtcgaacta tacagttcca acctcatcaa atatggcatc tcccttgcct     2880

gctatagcag ggggaggaaa aaatgccacc atctttttaa tctagcaagc ttctcttttc     2940

ttcatctttt tttttttctt ttaaaaaaat tctgatcatg gatgcttctt ccgatcccta     3000

tttgccttat gacgggggag gagacaatat ccccttgagg gaattacata aaagaggtaa     3060

gagcatcccc ttgctctgaa tcctctgttg gttgttgtgc atgcggctgg gcggttctgg     3120

ggacaggctg tctgttgtcc tcttgctgca atgtgctgct tagttgccct gccttgttgc     3180

tgtgggagaa tgcgaccttc ccagcagggc tggccctccc tgattgtttg ctctgtgcag     3240

attagccctg cttcagatca catagggctg cagactccat cttctgtgtg aaaatgcttt     3300

cggtttgatt gcagaaataa gctgccttta cagccagcta aagtcctggt ggttggttgg     3360

cacctgcaaa gtagtatttt tgtacctctg gaaacttata ttttctttac acagcaatat     3420

caagtgccgg tatgccattc tgttttggct gctgccaatt accatgtaga ctttgcacca     3480

cagagtaata gtaaaagctc ctagctgcat tttataacat ttaaaaatag caggaaagaa     3540

gaattatttt tgatttaaca tgtttttgtc atttaacgtc ttaactgatt gacatactat     3600

attgtctgtc tcgtgggtat cttgtacaac ttgataggat aaagcaattt agtttttttt     3660

ttttttttta aatacatcca gaatgtaagt cgtcagtagt tttcgaacag ataagtaatg     3720

gtgttaatct tttggcaggc tttgccttgg tctccttaaa gctaattagg tgttacttaa     3780

ttaaactgct cttttgctca ttttcttaaa ttattttttt aaaagatagt tggcatttgc     3840

tgttctagaa ataaacttca agaaacattc tttagccaga tgacttcatg tatgagccat     3900

gttagtttga attatttgct tggtgttata aactttatgg tttaatacca acttttatta     3960

tgtttacaag gtaaataagg aaaatttcaa gtacattttg tatcctgaga acaaatttaa     4020

gttccataga atttaggaat tacaatgtat tcaacagata cttacttgtc atactgtgcc     4080

tgcaaaacaa taattagact ctgaacaggt gcaacaattt tctgtagaat tagacaagtc     4140

ttcttttggc aggtgttact aagtaggcca tttcccaagg aacagggaat ttgccaggct     4200

tttgtggtgg agagaataga atgaataaat gctgtgggga gtaaagagct tgtcagaaga     4260

tgattagttc tgtggcacca aaaccaagag atcagttttc ctgtgagaag taaaggaagc     4320

attgtagaaa aatagatgtg ttgaagtcta ccggtggagt tccgcgttac ataacttacg     4380

gtaaatggcc cgcctggctg accgcccaac gacccccgcc cattgacgtc aataatgacg     4440

tatgttccca tagtaacgcc aatagggact ttccattgac gtcaatgggt ggagtattta     4500

cggtaaactg cccacttggc agtacatcaa gtgtatcata tgccaagtac gccccctatt     4560

gacgtcaatg acggtaaatg gcccgcctgg cattatgccc agtacatgac cttatgggac     4620

tttcctactt ggcagtacat ctacgtatta gtcatcgcta ttaccattgt gatgcggttt     4680

tggcagtaca tcaatgggcg tggatagcgg tttgactcac ggggatttcc aagtctccac     4740

cccattgacg tcaatgggag tttgttttgg caccaaaatc aacgggactt tccaaaatgt     4800

cgtaacaact ccgccccatt gacgcaaatg ggcggtaggc gtgtacggtg ggaggtctat     4860

ataagcagag ctcgtttagt gaaccgtcag atctacctct tccgcatcgc tgtctgcgag     4920

ggccagctgt tggggtgagt actccctctc aaaagcgggc atgacttctg cgctaagatt     4980

gtcagtttcc aaaaacgagg aggatttgat attcacctgg cccgcggtga tgcctttgag     5040

ggtggccgcg tccatctggt cagaaaagac aatctttttg ttgtcaagct tccttgatga     5100

tgtcatactt atcctgtccc ttttttttcc acagctcgcg gttgaggaca aactcttcgc     5160

ggtctttcca gtactcttgg atcggaaacc cgtcggcctc cgaacggtac tccgccaccg     5220

agggacctga gcgagtccgc atcgaccgga tcggaaaacc tcggatccga attcatagat     5280

aactgatcca gtgcccctaa cgttactggc cgaagccgct tggaataagg ccggtgtgcg     5340

tttgtctata tgttattttc caccatattg ccgtcttttg gcaatgtgag ggcccggaaa     5400

cctggccctg tcttcttgac gagcattcct aggggtcttt cccctctcgc caaaggaatg     5460

caaggtctgt tgaatgtcgt gaaggaagca gttcctctgg aagcttcttg aagacaaaca     5520

acgtctgtag cgaccctttg caggcagcgg aaccccccac ctggcgacag gtgcctctgc     5580

ggccaaaagc cacgtgtata agatacacct gcaaaggcgg cacaacccca gtgccacgtt     5640

gtgagttgga tagttgtgga aagagtcaaa tggctctcct caagcgtatt caacaagggg     5700

ctgaaggatg cccagaaggt accccattgt atgggatctg atctggggcc tcggtgcaca     5760

tgctttacat gtgtttagtc gaggttaaaa aaacgtctag gccccccgaa ccacggggac     5820

gtggttttcc tttgaaaaac acgatgataa atggccacct cagcaagttc ccacttgaac     5880

aaaaacatca agcaaatgta cttgtgcctg ccccagggtg agaaagtcca agccatgtat     5940

atctgggttg atggtactgg agaaggactg cgctgcaaaa cccgcaccct ggactgtgag     6000

cccaagtgtg tagaagagtt acctgagtgg aattttgatg gctctagtac ctttcagtct     6060

gagggctcca acagtgacat gtatctcagc cctgttgcca tgtttcggga ccccttccgc     6120

agagatccca acaagctggt gttctgtgaa gttttcaagt acaaccggaa gcctgcagag     6180

accaatttaa ggcactcgtg taaacggata atggacatgg tgagcaacca gcacccctgg     6240

tttggaatgg aacaggagta tactctgatg ggaacagatg ggcacccttt tggttggcct     6300

tccaatggct ttcctgggcc ccaaggtccg tattactgtg gtgtgggcgc agacaaagcc     6360

tatggcaggg atatcgtgga ggctcactac cgcgcctgct tgtatgctgg ggtcaagatt     6420

acaggaacaa atgctgaggt catgcctgcc cagtgggagt tccaaatagg accctgtgaa     6480

ggaatccgca tgggagatca tctctgggtg gcccgtttca tcttgcatcg agtatgtgaa     6540

gactttgggg taatagcaac ctttgacccc aagcccattc ctgggaactg gaatggtgca     6600

ggctgccata ccaactttag caccaaggcc atgcgggagg agaatggtct gaagcacatc     6660

gaggaggcca tcgagaaact aagcaagcgg caccggtacc acattcgagc ctacgatccc     6720

aaggggggcc tggacaatgc ccgtcgtctg actgggttcc acgaaacgtc caacatcaac     6780

gacttttctg ctggtgtcgc caatcgcagt gccagcatcc gcattccccg gactgtcggc     6840

caggagaaga aaggttactt tgaagaccgc cgcccctctg ccaattgtga cccctttgca     6900

gtgacagaag ccatcgtccg cacatgcctt ctcaatgaga ctggcgacga gcccttccaa     6960

tacaaaaact aatctagatc cccctcgctt tcttgctgtc caatttctat taaaggttcc     7020

tttgttccct aagtccaact actaaactgg gggatattat gaagggcctt gagcatctgg     7080

attctgccta ataaaaaaca tttattttca ttgcaatgat gtatttaaat tatttctgaa     7140

tattttacta aaaagggaat gtgggaggtc agtgcattta aaacataaag aaatgaagag     7200

ggggatcttc gcgatactgc atcgatgagg gacagccccc ccccaaagcc cccagggatg     7260

taattacgtc cctcccccgc tagggggcag cagcgagccg cccggggctc cgctccggtc     7320

cggcgctccc cccgcatccc cgagccggca gcgtgcgggg acagcccggg cacggggaag     7380

gtggcacggg atcgctttcc tctgaacgct tctcgctgct ctttgagcct gcagacacct     7440

ggggggatac ggggaaaata gacaccgcgg tggagctcca gcttttgttc cctttagtga     7500

gggttaatta gttcttaata cgactcacta tagggcgaat tggctaccgg gccgcccatc     7560

gagggtatca taagcttata tctataacaa gaaaatatat atataataag ttatcacgta     7620

agtagaacat gaaataacaa tataattatc gtatgagtta aatcttaaaa gtcacgtaaa     7680

agataatcat gcgtcatttt gactcacgcg gtcgttatag ttcaaaatca gtgacactta     7740

ccgcattgac aagcacgcct cacgggagct ccaagcggcg actgagatgt cctaaatgca     7800

cagcgacgga ttcgcgctat ttagaaagag agagcaatat ttcaagaatg catgcgtcaa     7860

ttttacgcag actatctttc tagggttaaa tcgatagatg cgatcctgca ggtctcccta     7920

tagtgagtcg tattaatttc gataagccag ctgcattaat gaatcggcca acgcgcgggg     7980

agaggcggtt tgcgtattgg gcgctcttcc gcttcctcgc tcactgactc gctgcgctcg     8040

gtcgttcggc tgcggcgagc ggtatcagct cactcaaagg cggtaatacg gttatccaca     8100

gaatcagggg ataacgcagg aaagaacatg tgagcaaaag gccagcaaaa ggccaggaac     8160

cgtaaaaagg ccgcgttgct ggcgtttttc cataggctcc gcccccctga cgagcatcac     8220

aaaaatcgac gctcaagtca gaggtggcga aacccgacag gactataaag ataccaggcg     8280

tttccccctg gaagctccct cgtgcgctct cctgttccga ccctgccgct taccggatac     8340

ctgtccgcct ttctcccttc gggaagcgtg gcgctttctc atagctcacg ctgtaggtat     8400

ctcagttcgg tgtaggtcgt tcgctccaag ctgggctgtg tgcacgaacc ccccgttcag     8460

cccgaccgct gcgccttatc cggtaactat cgtcttgagt ccaacccggt aagacacgac     8520

ttatcgccac tggcagcagc cactggtaac aggattagca gagcgaggta tgtaggcggt     8580

gctacagagt tcttgaagtg gtggcctaac tacggctaca ctagaaggac agtatttggt     8640

atctgcgctc tgctgaagcc agttaccttc ggaaaaagag ttggtagctc ttgatccggc     8700

aaacaaacca ccgctggtag cggtggtttt tttgtttgca agcagcagat tacgcgcaga     8760

aaaaaaggat ctcaagaaga tcctttgatc ttttctacgg ggtctgacgc tcagtggaac     8820

gaaaactcac gttaagggat tttggtcatg agattatcaa aaaggatctt cacctagatc     8880

cttttaaatt aaaaatgaag ttttaaatca atctaaagta tatatgagta aacttggtct     8940

gacagttacc aatgcttaat cagtgaggca cctatctcag cgatctgtct atttcgttca     9000

tccatagttg cctgactccc cgtcgtgtag ataactacga tacgggaggg cttaccatct     9060

ggccccagtg ctgcaatgat accgcgagac ccacgctcac cggctccaga tttatcagca     9120

ataaaccagc cagccggaag ggccgagcgc agaagtggtc ctgcaacttt atccgcctcc     9180

atccagtcta ttaattgttg ccgggaagct agagtaagta gttcgccagt taatagtttg     9240

cgcaacgttg ttgccattgc tacaggcatc gtggtgtcac gctcgtcgtt tggtatggct     9300

tcattcagct ccggttccca acgatcaagg cgagttacat gatcccccat gttgtgcaaa     9360

aaagcggtta gctccttcgg tcctccgatc gttgtcagaa gtaagttggc cgcagtgtta     9420

tcactcatgg ttatggcagc actgcataat tctcttactg tcatgccatc cgtaagatgc     9480

ttttctgtga ctggtgagta ctcaaccaag tcattctgag aatagtgtat gcggcgaccg     9540

agttgctctt gcccggcgtc aatacgggat aataccgcgc cacatagcag aactttaaaa     9600

gtgctcatca ttggaaaacg ttcttcgggg cgaaaactct caaggatctt accgctgttg     9660

agatccagtt cgatgtaacc cactcgtgca cccaactgat cttcagcatc ttttactttc     9720

accagcgttt ctgggtgagc aaaaacagga aggcaaaatg ccgcaaaaaa gggaataagg     9780

gcgacacgga aatgttgaat actcatactc ttcctttttc aatattattg aagcatttat     9840

cagggttatt gtctcatgag cggatacata tttgaatgta tttagaaaaa taaacaaata     9900

ggggttccgc gcacatttcc ccgaaaagtg ccacctgacg tctaagaaac cattattatc     9960

atgacattaa cctataaaaa taggcgtatc acgaggccct ttcgtctcgc gcgtttcggt    10020

gatgacggtg aaaacctctg acacatgcag ctcccggaga cggtcacagc ttgtctgtaa    10080

gcggatgccg ggagcagaca agcccgtcag ggcgcgtcag cgggtgttgg cgggtgtcgg    10140

ggctggctta actatgcggc atcagagcag attgtactga gagtgcacca tatcgacgct    10200

ctcccttatg cgactcctgc attaggaagc agcccagtag taggttgagg ccgttgagca    10260

ccgccgccgc aaggaatggt gcatgcaagg agatggcgcc caacagtccc ccggccacgg    10320

ggcctgccac catacccacg ccgaaacaag cgctcatgag cccgaagtgg cgagcccgat    10380

cttccccatc ggtgatgtcg gcgatatagg cgccagcaac cgcacctgtg gcgccggtga    10440

tgccggccac gatgcgtccg gcgtagagga tctggctagc gatgaccctg ctgattggtt    10500

cgctgaccat ttccggggtg cggaacggcg ttaccagaaa ctcagaaggt tcgtccaacc    10560

aaaccgactc tgacggcagt ttacgagaga gatgataggg tctgcttcag taagccagat    10620

gctacacaat taggcttgta catattgtcg ttagaacgcg gctacaatta atacataacc    10680

ttatgtatca tacacatacg atttaggtga cactatagaa tacacctgca ggacgtccca    10740

atgatcttaa gttaa                                                     10755


<210>  29
<211>  10748
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  pCLD17

<400>  29
ccctagaaag ataatcatat tgtgacgtac gttaaagata atcatgcgta aaattgacgc       60

atgtgtttta tcggtctgta tatcgaggtt tatttattaa tttgaataga tattaagttt      120

tattatattt acacttacat actaataata aattcaacaa acaatttatt tatgtttatt      180

tatttattaa aaaaaaacaa aaactcaaaa tttcttctat aaagtaacaa aacttttatc      240

gaatttgcag cccgggacta gctagaggga cagccccccc ccaaagcccc cagggatgta      300

attacgtccc tcccccgcta gggggcagca gcgagccgcc cggggctccg ctccggtccg      360

gcgctccccc cgcatccccg agccggcagc gtgcggggac agcccgggca cggggaaggt      420

ggcacgggat cgctttcctc tgaacgcttc tcgctgctct ttgagcctgc agacacctgg      480

ggggatacgg ggaaaactta agatccgacc ggacgcgtac tgagagcgct attctgaact      540

tttcttttgt tcccttccct tctaccacac cctaattgta atccatttta atttcctggt      600

cacagtcctg tctctccttc cattgtacct tgcccttttc taaagagcga ctgcaaagta      660

tgtttgcgta ggtgaggatc taaaacttta tgaggtacga acatcacaga attactttgt      720

aatttcagtt tattgtaggc ttggcttttt ggggagggtt tacgtcttag acctcttagt      780

gcttctttgt ttcatggtgt tctaacttcg aagcatctct gtagctttaa tggattcctt      840

ttctgaaagc tttgctctct ttcttccccc tcggctttct cttaggcaag agggctaact      900

gtaaagtaag gcttactgcc ttgtgtttcc aaatgtgtcc gaagaggaag tgtcttctgt      960

gaatcctgtt atgcatgaat aacaggaaat agaaagaaat tcactttcat tattataaaa     1020

gtaatatgtt cgtttaaaaa attctaatga agagctggag atgcaaccca ggggtagagc     1080

acacactcag catgcaggag gccctgggtc caatcttgga atctcctctc agttaacctg     1140

atctctagct gattagtagt gagtgcaagc ccactttcct cttctgcctc attgctcagt     1200

gataacagct gttaaacttt gtcttattct aaaactacct ctgtgcaaat gctagcacaa     1260

taatatatat catatgcaca tgattttttt tttatcttga aaagtaagtc agtatagcta     1320

caaagttcac ttggcattgt caacatttca caggcgtaat attcctcctc tagtactgtc     1380

ctcttcattc tttgtgacca agtttggaga gagtgcacaa atgccaggga ggtttgtggg     1440

aaggtttctc atgttctggt aaggcgagta agaaaatagt ctcatgcagg tgaaatgagt     1500

gctatgcagt atatattata ccagagaaca gcaaatgacc aaattcacac tgaactagtt     1560

cagtaaaatt ggctttgtca aagctttcct tgcttaaaat gtaattccct gtcatcctag     1620

ttctggtctg gattcttttc ctggagtctt gacttccaga ttccctgtgg acttttgttt     1680

gagtttcaag cttttgaaat atagaaacct atctaactta acaaacttgg gagagaaaag     1740

actccagaac aactgaaaac agaccaggct aaatgaatag actttattcc tctcttctta     1800

cctgcagttt tcagatatgc agagttggag cggatcttag aggttgattc attcatgcct     1860

gaagaaaaca cattttatag accctgtgcc caagttcgtg gtggacatca ccctttattt     1920

actaattgca ctacataaca ggcattttag aagactgctc cagtcagaga ccccgcctta     1980

gaggaatctg taaaccctga actcctatca ctcatgagca ctagttatgt ttggaatgcc     2040

gtattaaaac aaaagttaca tttctaaact taaaattttc tagcacagag acagtgggag     2100

tagctaactt tgatagacat ttttctacta aaagtctttc taagtacata atcttctgta     2160

agttggaaaa cagcaaaata gaacgtctcc tacgtagtta atctttttgc ataatttgca     2220

catgtaggag ttattagtat acgggtaagt tttcactttt tcccccaact ggagtgtctt     2280

gtggctgggt ttgaaaaagg gaacgggagg ccgctggagg ggattggtaa atgagataaa     2340

acaccactca ttcaactcag tgactcagca tttaaatttt ccataaaagg attaaaggaa     2400

aattaaacaa attcttaaag ccaagactct ggagaaactt gttggtgtgc tttagttttc     2460

actgttatga ctcatgaatt tatgcataaa ttagtacatt tataaaaaca tagccttttt     2520

agagttttct gtttggctaa agtgccattg ttagcatttg gaattacctt tttatgtctt     2580

atattttttc caaataaaaa taaatgtttc tgctgtctta ctactgaaac tacgttgtga     2640

gcactttaaa tttctcaaag cagtttcgcc tgttatactt ggcgcttagt catcgtcgta     2700

cacaacagga cctgattaag aaggctgtgc tgcctctaag ccgggctaga ttgtagccac     2760

tagcaaccag gctgcaataa tttccctttg atgacatcat ccactgtgga agaacccagt     2820

tgcttcagcc agtcgaacta tacagttcca acctcatcaa atatggcatc tcccttgcct     2880

gctatagcag ggggaggaaa aaatgccacc atctttttaa tctagcaagc ttctcttttc     2940

ttcatctttt tttttttctt ttaaaaaaat tctgatcatg gatgcttctt ccgatcccta     3000

tttgccttat gacgggggag gagacaatat ccccttgagg gaattacata aaagaggtaa     3060

gagcatcccc ttgctctgaa tcctctgttg gttgttgtgc atgcggctgg gcggttctgg     3120

ggacaggctg tctgttgtcc tcttgctgca atgtgctgct tagttgccct gccttgttgc     3180

tgtgggagaa tgcgaccttc ccagcagggc tggccctccc tgattgtttg ctctgtgcag     3240

attagccctg cttcagatca catagggctg cagactccat cttctgtgtg aaaatgcttt     3300

cggtttgatt gcagaaataa gctgccttta cagccagcta aagtcctggt ggttggttgg     3360

cacctgcaaa gtagtatttt tgtacctctg gaaacttata ttttctttac acagcaatat     3420

caagtgccgg tatgccattc tgttttggct gctgccaatt accatgtaga ctttgcacca     3480

cagagtaata gtaaaagctc ctagctgcat tttataacat ttaaaaatag caggaaagaa     3540

gaattatttt tgatttaaca tgtttttgtc atttaacgtc ttaactgatt gacatactat     3600

attgtctgtc tcgtgggtat cttgtacaac ttgataggat aaagcaattt agtttttttt     3660

ttttttttta aatacatcca gaatgtaagt cgtcagtagt tttcgaacag ataagtaatg     3720

gtgttaatct tttggcaggc tttgccttgg tctccttaaa gctaattagg tgttacttaa     3780

ttaaactgct cttttgctca ttttcttaaa ttattttttt aaaagatagt tggcatttgc     3840

tgttctagaa ataaacttca agaaacattc tttagccaga tgacttcatg tatgagccat     3900

gttagtttga attatttgct tggtgttata aactttatgg tttaatacca acttttatta     3960

tgtttacaag gtaaataagg aaaatttcaa gtacattttg tatcctgaga acaaatttaa     4020

gttccataga atttaggaat tacaatgtat tcaacagata cttacttgtc atactgtgcc     4080

tgcaaaacaa taattagact ctgaacaggt gcaacaattt tctgtagaat tagacaagtc     4140

ttcttttggc aggtgttact aagtaggcca tttcccaagg aacagggaat ttgccaggct     4200

tttgtggtgg agagaataga atgaataaat gctgtgggga gtaaagagct tgtcagaaga     4260

tgattagttc tgtggcacca aaaccaagag atcagttttc ctgtgagaag taaaggaagc     4320

attgtagaaa aatagatgtg ttgaagtcta ccggtggagt tccgcgttac ataacttacg     4380

gtaaatggcc cgcctggctg accgcccaac gacccccgcc cattgacgtc aataatgacg     4440

tatgttccca tagtaacgcc aatagggact ttccattgac gtcaatgggt ggagtattta     4500

cggtaaactg cccacttggc agtacatcaa gtgtatcata tgccaagtac gccccctatt     4560

gacgtcaatg acggtaaatg gcccgcctgg cattatgccc agtacatgac cttatgggac     4620

tttcctactt ggcagtacat ctacgtatta gtcatcgcta ttaccattgt gatgcggttt     4680

tggcagtaca tcaatgggcg tggatagcgg tttgactcac ggggatttcc aagtctccac     4740

cccattgacg tcaatgggag tttgttttgg caccaaaatc aacgggactt tccaaaatgt     4800

cgtaacaact ccgccccatt gacgcaaatg ggcggtaggc gtgtacggtg ggaggtctat     4860

ataagcagag ctcgtttagt gaaccgtcag atctacctct tccgcatcgc tgtctgcgag     4920

ggccagctgt tggggtgagt actccctctc aaaagcgggc atgacttctg cgctaagatt     4980

gtcagtttcc aaaaacgagg aggatttgat attcacctgg cccgcggtga tgcctttgag     5040

ggtggccgcg tccatctggt cagaaaagac aatctttttg ttgtcaagct tccttgatga     5100

tgtcatactt atcctgtccc ttttttttcc acagctcgcg gttgaggaca aactcttcgc     5160

ggtctttcca gtactcttgg atcggaaacc cgtcggcctc cgaacggtac tccgccaccg     5220

agggacctga gcgagtccgc atcgaccgga tcggaaaacc tcggatccga attcatagat     5280

aactgatcca gtgcccctaa cgttactggc cgaagccgct tggaataagg ccggtgtgcg     5340

tttgtctata tgttattttc caccatattg ccgtcttttg gcaatgtgag ggcccggaaa     5400

cctggccctg tcttcttgac gagcattcct aggggtcttt cccctctcgc caaaggaatg     5460

caaggtctgt tgaatgtcgt gaaggaagca gttcctctgg aagcttcttg aagacaaaca     5520

acgtctgtag cgaccctttg caggcagcgg aaccccccac ctggcgacag gtgcctctgc     5580

ggccaaaagc cacgtgtata agatacacct gcaaaggcgg cacaacccca gtgccacgtt     5640

gtgagttgga tagttgtgga aagagtcaaa tggctctcct caagcgtatt caacaagggg     5700

ctgaaggatg cccagaaggt accccattgt atgggatctg atctggggcc tcggtgcaca     5760

tgctttacat gtgtttagtc gaggttaaaa aaacgtctag gccccccgaa ccacggggac     5820

gtggttttcc tttgaaaaac acgatggcca cctcagcaag ttcccacttg aacaaaaaca     5880

tcaagcaaat gtacttgtgc ctgccccagg gtgagaaagt ccaagccatg tatatctggg     5940

ttgatggtac tggagaagga ctgcgctgca aaacccgcac cctggactgt gagcccaagt     6000

gtgtagaaga gttacctgag tggaattttg atggctctag tacctttcag tctgagggct     6060

ccaacagtga catgtatctc agccctgttg ccatgtttcg ggaccccttc cgcagagatc     6120

ccaacaagct ggtgttctgt gaagttttca agtacaaccg gaagcctgca gagaccaatt     6180

taaggcactc gtgtaaacgg ataatggaca tggtgagcaa ccagcacccc tggtttggaa     6240

tggaacagga gtatactctg atgggaacag atgggcaccc ttttggttgg ccttccaatg     6300

gctttcctgg gccccaaggt ccgtattact gtggtgtggg cgcagacaaa gcctatggca     6360

gggatatcgt ggaggctcac taccgcgcct gcttgtatgc tggggtcaag attacaggaa     6420

caaatgctga ggtcatgcct gcccagtggg agttccaaat aggaccctgt gaaggaatcc     6480

gcatgggaga tcatctctgg gtggcccgtt tcatcttgca tcgagtatgt gaagactttg     6540

gggtaatagc aacctttgac cccaagccca ttcctgggaa ctggaatggt gcaggctgcc     6600

ataccaactt tagcaccaag gccatgcggg aggagaatgg tctgaagcac atcgaggagg     6660

ccatcgagaa actaagcaag cggcaccggt accacattcg agcctacgat cccaaggggg     6720

gcctggacaa tgcccgtcgt ctgactgggt tccacgaaac gtccaacatc aacgactttt     6780

ctgctggtgt cgccaatcgc agtgccagca tccgcattcc ccggactgtc ggccaggaga     6840

agaaaggtta ctttgaagac cgccgcccct ctgccaattg tgaccccttt gcagtgacag     6900

aagccatcgt ccgcacatgc cttctcaatg agactggcga cgagcccttc caatacaaaa     6960

actaatctag atccccctcg ctttcttgct gtccaatttc tattaaaggt tcctttgttc     7020

cctaagtcca actactaaac tgggggatat tatgaagggc cttgagcatc tggattctgc     7080

ctaataaaaa acatttattt tcattgcaat gatgtattta aattatttct gaatatttta     7140

ctaaaaaggg aatgtgggag gtcagtgcat ttaaaacata aagaaatgaa gagggggatc     7200

ttcgcgatac tgcatcgatg agggacagcc cccccccaaa gcccccaggg atgtaattac     7260

gtccctcccc cgctaggggg cagcagcgag ccgcccgggg ctccgctccg gtccggcgct     7320

ccccccgcat ccccgagccg gcagcgtgcg gggacagccc gggcacgggg aaggtggcac     7380

gggatcgctt tcctctgaac gcttctcgct gctctttgag cctgcagaca cctgggggga     7440

tacggggaaa atagacaccg cggtggagct ccagcttttg ttccctttag tgagggttaa     7500

ttagttctta atacgactca ctatagggcg aattggctac cgggccgccc atcgagggta     7560

tcataagctt atatctataa caagaaaata tatatataat aagttatcac gtaagtagaa     7620

catgaaataa caatataatt atcgtatgag ttaaatctta aaagtcacgt aaaagataat     7680

catgcgtcat tttgactcac gcggtcgtta tagttcaaaa tcagtgacac ttaccgcatt     7740

gacaagcacg cctcacggga gctccaagcg gcgactgaga tgtcctaaat gcacagcgac     7800

ggattcgcgc tatttagaaa gagagagcaa tatttcaaga atgcatgcgt caattttacg     7860

cagactatct ttctagggtt aaatcgatag atgcgatcct gcaggtctcc ctatagtgag     7920

tcgtattaat ttcgataagc cagctgcatt aatgaatcgg ccaacgcgcg gggagaggcg     7980

gtttgcgtat tgggcgctct tccgcttcct cgctcactga ctcgctgcgc tcggtcgttc     8040

ggctgcggcg agcggtatca gctcactcaa aggcggtaat acggttatcc acagaatcag     8100

gggataacgc aggaaagaac atgtgagcaa aaggccagca aaaggccagg aaccgtaaaa     8160

aggccgcgtt gctggcgttt ttccataggc tccgcccccc tgacgagcat cacaaaaatc     8220

gacgctcaag tcagaggtgg cgaaacccga caggactata aagataccag gcgtttcccc     8280

ctggaagctc cctcgtgcgc tctcctgttc cgaccctgcc gcttaccgga tacctgtccg     8340

cctttctccc ttcgggaagc gtggcgcttt ctcatagctc acgctgtagg tatctcagtt     8400

cggtgtaggt cgttcgctcc aagctgggct gtgtgcacga accccccgtt cagcccgacc     8460

gctgcgcctt atccggtaac tatcgtcttg agtccaaccc ggtaagacac gacttatcgc     8520

cactggcagc agccactggt aacaggatta gcagagcgag gtatgtaggc ggtgctacag     8580

agttcttgaa gtggtggcct aactacggct acactagaag gacagtattt ggtatctgcg     8640

ctctgctgaa gccagttacc ttcggaaaaa gagttggtag ctcttgatcc ggcaaacaaa     8700

ccaccgctgg tagcggtggt ttttttgttt gcaagcagca gattacgcgc agaaaaaaag     8760

gatctcaaga agatcctttg atcttttcta cggggtctga cgctcagtgg aacgaaaact     8820

cacgttaagg gattttggtc atgagattat caaaaaggat cttcacctag atccttttaa     8880

attaaaaatg aagttttaaa tcaatctaaa gtatatatga gtaaacttgg tctgacagtt     8940

accaatgctt aatcagtgag gcacctatct cagcgatctg tctatttcgt tcatccatag     9000

ttgcctgact ccccgtcgtg tagataacta cgatacggga gggcttacca tctggcccca     9060

gtgctgcaat gataccgcga gacccacgct caccggctcc agatttatca gcaataaacc     9120

agccagccgg aagggccgag cgcagaagtg gtcctgcaac tttatccgcc tccatccagt     9180

ctattaattg ttgccgggaa gctagagtaa gtagttcgcc agttaatagt ttgcgcaacg     9240

ttgttgccat tgctacaggc atcgtggtgt cacgctcgtc gtttggtatg gcttcattca     9300

gctccggttc ccaacgatca aggcgagtta catgatcccc catgttgtgc aaaaaagcgg     9360

ttagctcctt cggtcctccg atcgttgtca gaagtaagtt ggccgcagtg ttatcactca     9420

tggttatggc agcactgcat aattctctta ctgtcatgcc atccgtaaga tgcttttctg     9480

tgactggtga gtactcaacc aagtcattct gagaatagtg tatgcggcga ccgagttgct     9540

cttgcccggc gtcaatacgg gataataccg cgccacatag cagaacttta aaagtgctca     9600

tcattggaaa acgttcttcg gggcgaaaac tctcaaggat cttaccgctg ttgagatcca     9660

gttcgatgta acccactcgt gcacccaact gatcttcagc atcttttact ttcaccagcg     9720

tttctgggtg agcaaaaaca ggaaggcaaa atgccgcaaa aaagggaata agggcgacac     9780

ggaaatgttg aatactcata ctcttccttt ttcaatatta ttgaagcatt tatcagggtt     9840

attgtctcat gagcggatac atatttgaat gtatttagaa aaataaacaa ataggggttc     9900

cgcgcacatt tccccgaaaa gtgccacctg acgtctaaga aaccattatt atcatgacat     9960

taacctataa aaataggcgt atcacgaggc cctttcgtct cgcgcgtttc ggtgatgacg    10020

gtgaaaacct ctgacacatg cagctcccgg agacggtcac agcttgtctg taagcggatg    10080

ccgggagcag acaagcccgt cagggcgcgt cagcgggtgt tggcgggtgt cggggctggc    10140

ttaactatgc ggcatcagag cagattgtac tgagagtgca ccatatcgac gctctccctt    10200

atgcgactcc tgcattagga agcagcccag tagtaggttg aggccgttga gcaccgccgc    10260

cgcaaggaat ggtgcatgca aggagatggc gcccaacagt cccccggcca cggggcctgc    10320

caccataccc acgccgaaac aagcgctcat gagcccgaag tggcgagccc gatcttcccc    10380

atcggtgatg tcggcgatat aggcgccagc aaccgcacct gtggcgccgg tgatgccggc    10440

cacgatgcgt ccggcgtaga ggatctggct agcgatgacc ctgctgattg gttcgctgac    10500

catttccggg gtgcggaacg gcgttaccag aaactcagaa ggttcgtcca accaaaccga    10560

ctctgacggc agtttacgag agagatgata gggtctgctt cagtaagcca gatgctacac    10620

aattaggctt gtacatattg tcgttagaac gcggctacaa ttaatacata accttatgta    10680

tcatacacat acgatttagg tgacactata gaatacacct gcaggacgtc ccaatgatct    10740

taagttaa                                                             10748


