                         SEQUENCE LISTING

<110>  Oldham, Robyn A.A.
       Faber, Mary L.
       Medin, Jeffrey A.
       Tate, Everett R.
 
<120>  ANTI-CD30 ANTIBODIES AND METHODS OF USE

<130>  650053.00640

<150>  US 62/735,508
<151>  2018-09-24

<160>  56    

<170>  PatentIn version 3.5

<210>  1
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic - 8D10 light chain

<400>  1

Asp Ile Val Met Thr Gln Ser Pro Ala Ser Gln Ser Ala Ser Leu Gly 
1               5                   10                  15      


Glu Ser Val Thr Ile Thr Cys Leu Ala Ser Gln Thr Ile Gly Thr Trp 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ser Pro Gln Phe Leu Ile 
        35                  40                  45              


Tyr Ala Ala Thr Ser Leu Ala Asp Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Lys Phe Ser Phe Lys Ile Ser Ser Leu Gln Ala 
65                  70                  75                  80  


Glu Asp Phe Val Ser Tyr Tyr Cys Gln Gln Leu Tyr Ser Thr Pro Phe 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105         


<210>  2
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic - CDRL1

<400>  2

Leu Ala Ser Gln Thr Ile Gly Thr Trp Leu Ala 
1               5                   10      


<210>  3
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic - CDRL2

<400>  3

Ala Ala Thr Ser Leu Ala Asp 
1               5           


<210>  4
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic - CDRL3

<400>  4

Gln Gln Leu Tyr Ser Thr Pro Phe Thr 
1               5                   


<210>  5
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic - 8D10 heavy chain

<400>  5

Gln Val Gln Leu Gln Glu Ser Gly Thr Glu Leu Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Leu Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


Trp Met His Trp Met Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Asn Ile Asn Pro Ser Asn Gly Gly Thr Asn Tyr Asn Glu Lys Phe 
    50                  55                  60                  


Lys Asn Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Arg Asp Tyr Tyr Tyr Gly Ser Ser Tyr Gly Phe Asp Val Trp 
            100                 105                 110         


Gly Thr Gly Thr Thr Val Thr Val Ser Ser 
        115                 120         


<210>  6
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic - CDH1

<400>  6

Gly Tyr Thr Phe Thr Ser Tyr 
1               5           


<210>  7
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic - CDH2

<400>  7

Asn Pro Ser Asn Gly Gly 
1               5       


<210>  8
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic - CDH3

<400>  8

Arg Asp Tyr Tyr Tyr Gly Ser Ser Tyr Gly Phe Asp Val 
1               5                   10              


<210>  9
<211>  112
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic - 10C2 light chain

<400>  9

Asp Ile Val Leu Thr Gln Thr Pro Leu Thr Leu Ser Val Thr Ile Gly 
1               5                   10                  15      


Gln Pro Ala Ser Ile Ser Cys Lys Ser Asn Gln Ser Leu Leu Asp Ser 
            20                  25                  30          


Tyr Gly Lys Thr Tyr Leu Asn Trp Leu Leu Gln Arg Pro Gly Gln Ser 
        35                  40                  45              


Pro Lys Arg Leu Ile Tyr Leu Val Ser Lys Leu Asp Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Thr Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Leu Gly Val Tyr Tyr Cys Trp Gln Gly 
                85                  90                  95      


Thr His Phe Pro Arg Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110         


<210>  10
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic - CDRL1

<400>  10

Lys Ser Asn Gln Ser Leu Leu Asp Ser Tyr Gly Lys Thr Tyr Leu Asn 
1               5                   10                  15      


<210>  11
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic - CDRL2

<400>  11

Leu Val Ser Lys Leu Asp Ser 
1               5           


<210>  12
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic - CDRL3

<400>  12

Trp Gln Gly Thr His Phe Pro Arg Thr 
1               5                   


<210>  13
<211>  112
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic - 10C2 heavy chain

<400>  13

Gln Val Gln Leu Glu Gln Ser Gly Pro Val Leu Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Met Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asp Tyr 
            20                  25                  30          


Tyr Met Asn Trp Val Lys Gln Ser His Gly Lys Ser Leu Glu Trp Ile 
        35                  40                  45              


Gly Val Ile Asn Pro Tyr Asn Gly Gly Thr Ser Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Lys Gly Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Ser Thr Ala Cys 
65                  70                  75                  80  


Met Glu Leu Asn Cys Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Thr Leu Gly Ala Tyr Trp Gly Gln Gly Thr Ser Val Thr Val Ser Ser 
            100                 105                 110         


<210>  14
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic - CDH1

<400>  14

Gly Tyr Thr Phe Thr Asp Tyr 
1               5           


<210>  15
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic - CDH2

<400>  15

Asn Pro Tyr Asn Gly 
1               5   


<210>  16
<211>  3
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic - CDH3

<400>  16

Gly Ala Tyr 
1           


<210>  17
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic - 12B1 light chain

<400>  17

Asp Ile Val Met Thr Gln Thr Thr Ala Ser Leu Ser Thr Ser Val Gly 
1               5                   10                  15      


Glu Thr Val Thr Ile Thr Cys Arg Ala Ser Gly Asn Leu His Ser Tyr 
            20                  25                  30          


Leu Thr Trp Tyr Gln Gln Lys Gln Gly Lys Ser Pro Gln Leu Leu Val 
        35                  40                  45              


Tyr Asn Ala Lys Thr Leu Ala Asp Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Gln Tyr Ser Leu Lys Ile Asp Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Gly Ser Tyr Tyr Cys Gln His Phe Trp Thr Thr Pro Phe 
                85                  90                  95      


Thr Phe Gly Ser Gly Thr Lys Leu Glu Ile Lys 
            100                 105         


<210>  18
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic - CDRL1

<400>  18

Arg Ala Ser Gly Asn Leu His Ser Tyr Leu Thr 
1               5                   10      


<210>  19
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic - CDRL2

<400>  19

Asn Ala Lys Thr Leu Ala Asp 
1               5           


<210>  20
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic - CDRL3

<400>  20

Gln His Phe Trp Thr Thr Pro Phe Thr 
1               5                   


<210>  21
<211>  120
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic - 12B1 heavy chain

<400>  21

Glu Val Lys Leu Glu Glu Ser Gly Thr Glu Leu Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Leu Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


Trp Met His Trp Val Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Asn Ile Asn Pro Thr Asn Gly Gly Thr Asn Tyr Asn Glu Lys Phe 
    50                  55                  60                  


Lys Ser Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Arg Thr Ala Tyr 
65                  70                  75                  80  


Met Gln Leu Ser Ser Leu Thr Ser Gly Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Arg Asp Phe Ile Thr Thr Ser Gly Phe Ala Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ala 
        115                 120 


<210>  22
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic - CDH1

<400>  22

Gly Tyr Thr Phe Thr Ser Tyr 
1               5           


<210>  23
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic - CDH2

<400>  23

Asn Pro Thr Asn Gly Gly 
1               5       


<210>  24
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic - CDH3

<400>  24

Arg Asp Phe Ile Thr Thr Ser Gly Phe Ala Tyr 
1               5                   10      


<210>  25
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic - 13H1 light chain

<400>  25

Asp Ile Val Met Thr Gln Thr Pro Lys Ser Met Ser Met Ser Val Gly 
1               5                   10                  15      


Glu Arg Val Thr Leu Ser Cys Lys Ala Ser Glu Asn Val Gly Thr Tyr 
            20                  25                  30          


Val Ser Trp Tyr Gln Gln Lys Pro Glu Gln Ser Pro Lys Val Leu Ile 
        35                  40                  45              


Tyr Gly Ala Ser Asn Arg Phe Thr Gly Val Pro Asp Arg Phe Thr Gly 
    50                  55                  60                  


Ser Gly Ser Ala Thr Asp Phe Thr Leu Thr Ile Ser Ser Val Gln Thr 
65                  70                  75                  80  


Glu Asp Leu Ala Asp Tyr His Cys Gly Gln Ser Tyr Ser Tyr Pro Leu 
                85                  90                  95      


Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys 
            100                 105         


<210>  26
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic - CDRL1

<400>  26

Lys Ala Ser Glu Asn Val Gly Thr Tyr Val Ser 
1               5                   10      


<210>  27
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic - CDRL2

<400>  27

Gly Ala Ser Asn Arg Phe Thr 
1               5           


<210>  28
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic - CDRL3

<400>  28

Gly Gln Ser Tyr Ser Tyr Pro Leu Thr 
1               5                   


<210>  29
<211>  123
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic - 13H1 heavy chain

<400>  29

Gln Val Gln Leu Gln Gln Ser Gly Thr Glu Leu Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Leu Ser Cys Lys Ala Ser Gly His Thr Phe Thr Ser Tyr 
            20                  25                  30          


Trp Met His Trp Val Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Asn Ile Asn Pro Ser Asn Gly Gly Thr Asn Tyr Asn Glu Lys Phe 
    50                  55                  60                  


Lys Ser Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Arg Gly Tyr Tyr Gly Ser Ser Ser Tyr Trp Ser Phe Asp Val 
            100                 105                 110         


Trp Gly Thr Gly Thr Thr Val Thr Val Ser Ser 
        115                 120             


<210>  30
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic - CDH1

<400>  30

Gly His Thr Phe Thr Ser Tyr 
1               5           


<210>  31
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic - CDH2

<400>  31

Asn Pro Ser Asn Gly Gly 
1               5       


<210>  32
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic - CDH3

<400>  32

Arg Gly Tyr Tyr Gly Ser Ser Ser Tyr Trp Ser Phe Asp Val 
1               5                   10                  


<210>  33
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic - 15B8 light chain

<400>  33

Asp Ile Val Met Thr Gln Thr Pro Ala Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Glu Thr Val Thr Ile Thr Cys Arg Ala Ser Gly Asn Ile His Asn Tyr 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Gln Gly Lys Ser Pro Gln Leu Leu Val 
        35                  40                  45              


Tyr Asn Ala Lys Thr Leu Ala Asp Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Gln Tyr Ser Leu Lys Ile Asn Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Gly Ser Tyr Tyr Cys Gln His Phe Trp Ser Thr Pro Phe 
                85                  90                  95      


Thr Phe Gly Ser Gly Thr Lys Leu Glu Ile Lys 
            100                 105         


<210>  34
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic - CDRL1

<400>  34

Arg Ala Ser Gly Asn Ile His Asn Tyr Leu Ala 
1               5                   10      


<210>  35
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic - CDRL2

<400>  35

Asn Ala Lys Thr Leu Ala Asp 
1               5           


<210>  36
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic - CDRL3

<400>  36

Gln His Phe Trp Ser Thr Pro Phe Thr 
1               5                   


<210>  37
<211>  121
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic - 15B8 heavy chain

<400>  37

Gln Val Gln Leu Glu Gln Ser Gly Thr Glu Leu Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Leu Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


Trp Met His Trp Val Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Asn Ile Asn Pro Ser Asn Gly Gly Thr Asn Tyr Asn Glu Lys Phe 
    50                  55                  60                  


Lys Ser Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Ile Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Arg Asn Asn Tyr Tyr Ala Ser Ser Pro Phe Ala Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Leu Val Ser Val Ser Ala 
        115                 120     


<210>  38
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic - CDH1

<400>  38

Gly Tyr Thr Phe Thr Ser Tyr 
1               5           


<210>  39
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic - CDH2

<400>  39

Asn Pro Ser Asn Gly Gly 
1               5       


<210>  40
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic - CDH3

<400>  40

Arg Asn Asn Tyr Tyr Ala Ser Ser Pro Phe Ala Tyr 
1               5                   10          


<210>  41
<211>  795
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic - 8D10

<400>  41
atggccttac cagtgaccgc cttgctcctg ccgctggcct tgctgctcca cgccgccagg       60

ccgcaagtac agctgcagga gtctgggact gaactggtga agcctggggc ttcagtgaag      120

ctgtcctgca aggcttctgg ctacaccttc accagctact ggatgcactg gatgaagcag      180

aggcctggac aaggccttga gtggattgga aatattaatc ctagcaatgg tggtactaac      240

tacaatgaga agttcaagaa caaggccaca ctgactgtag acaaatcctc cagcacagcc      300

tacatgcagc tcagcagcct gacatctgag gactctgcgg tctattattg tgcaagaagg      360

gattattact acggtagtag ctacggcttc gatgtctggg gcacagggac cacggtcacc      420

gtctcctcag gtggcggtgg ctcgggcggt ggtgggtcgg gtggcggcgg atctgatatt      480

gtgatgaccc agtctcctgc ctcccagtct gcatctctgg gagaaagtgt caccatcaca      540

tgcctggcaa gtcagaccat tggtacatgg ttagcatggt atcagcagaa accagggaaa      600

tctcctcagt tcctgattta tgctgcaacc agcttggcag atggggtccc atcaaggttc      660

agtggtagtg gatctggcac aaaattttct ttcaagatca gcagcctaca ggctgaagat      720

tttgtaagtt attactgtca acaactttac agtactccgt tcacgttcgg aggggggacc      780

aagctggaaa taaaa                                                       795


<210>  42
<211>  265
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic - 8D10

<400>  42

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Gln Val Gln Leu Gln Glu Ser Gly Thr Glu Leu 
            20                  25                  30          


Val Lys Pro Gly Ala Ser Val Lys Leu Ser Cys Lys Ala Ser Gly Tyr 
        35                  40                  45              


Thr Phe Thr Ser Tyr Trp Met His Trp Met Lys Gln Arg Pro Gly Gln 
    50                  55                  60                  


Gly Leu Glu Trp Ile Gly Asn Ile Asn Pro Ser Asn Gly Gly Thr Asn 
65                  70                  75                  80  


Tyr Asn Glu Lys Phe Lys Asn Lys Ala Thr Leu Thr Val Asp Lys Ser 
                85                  90                  95      


Ser Ser Thr Ala Tyr Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser 
            100                 105                 110         


Ala Val Tyr Tyr Cys Ala Arg Arg Asp Tyr Tyr Tyr Gly Ser Ser Tyr 
        115                 120                 125             


Gly Phe Asp Val Trp Gly Thr Gly Thr Thr Val Thr Val Ser Ser Gly 
    130                 135                 140                 


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile 
145                 150                 155                 160 


Val Met Thr Gln Ser Pro Ala Ser Gln Ser Ala Ser Leu Gly Glu Ser 
                165                 170                 175     


Val Thr Ile Thr Cys Leu Ala Ser Gln Thr Ile Gly Thr Trp Leu Ala 
            180                 185                 190         


Trp Tyr Gln Gln Lys Pro Gly Lys Ser Pro Gln Phe Leu Ile Tyr Ala 
        195                 200                 205             


Ala Thr Ser Leu Ala Asp Gly Val Pro Ser Arg Phe Ser Gly Ser Gly 
    210                 215                 220                 


Ser Gly Thr Lys Phe Ser Phe Lys Ile Ser Ser Leu Gln Ala Glu Asp 
225                 230                 235                 240 


Phe Val Ser Tyr Tyr Cys Gln Gln Leu Tyr Ser Thr Pro Phe Thr Phe 
                245                 250                 255     


Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            260                 265 


<210>  43
<211>  795
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic - 8D10

<400>  43
atggccttac cagtgaccgc cttgctcctg ccgctggcct tgctgctcca cgccgccagg       60

ccggatattg tgatgaccca gtctcctgcc tcccagtctg catctctggg agaaagtgtc      120

accatcacat gcctggcaag tcagaccatt ggtacatggt tagcatggta tcagcagaaa      180

ccagggaaat ctcctcagtt cctgatttat gctgcaacca gcttggcaga tggggtccca      240

tcaaggttca gtggtagtgg atctggcaca aaattttctt tcaagatcag cagcctacag      300

gctgaagatt ttgtaagtta ttactgtcaa caactttaca gtactccgtt cacgttcgga      360

ggggggacca agctggaaat aaaaggtggc ggtggctcgg gcggtggtgg gtcgggtggc      420

ggcggatctc aagtacagct gcaggagtct gggactgaac tggtgaagcc tggggcttca      480

gtgaagctgt cctgcaaggc ttctggctac accttcacca gctactggat gcactggatg      540

aagcagaggc ctggacaagg ccttgagtgg attggaaata ttaatcctag caatggtggt      600

actaactaca atgagaagtt caagaacaag gccacactga ctgtagacaa atcctccagc      660

acagcctaca tgcagctcag cagcctgaca tctgaggact ctgcggtcta ttattgtgca      720

agaagggatt attactacgg tagtagctac ggcttcgatg tctggggcac agggaccacg      780

gtcaccgtct cctca                                                       795


<210>  44
<211>  265
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic - 8D10

<400>  44

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Asp Ile Val Met Thr Gln Ser Pro Ala Ser Gln 
            20                  25                  30          


Ser Ala Ser Leu Gly Glu Ser Val Thr Ile Thr Cys Leu Ala Ser Gln 
        35                  40                  45              


Thr Ile Gly Thr Trp Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ser 
    50                  55                  60                  


Pro Gln Phe Leu Ile Tyr Ala Ala Thr Ser Leu Ala Asp Gly Val Pro 
65                  70                  75                  80  


Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Lys Phe Ser Phe Lys Ile 
                85                  90                  95      


Ser Ser Leu Gln Ala Glu Asp Phe Val Ser Tyr Tyr Cys Gln Gln Leu 
            100                 105                 110         


Tyr Ser Thr Pro Phe Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
        115                 120                 125             


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln 
    130                 135                 140                 


Val Gln Leu Gln Glu Ser Gly Thr Glu Leu Val Lys Pro Gly Ala Ser 
145                 150                 155                 160 


Val Lys Leu Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr Trp 
                165                 170                 175     


Met His Trp Met Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile Gly 
            180                 185                 190         


Asn Ile Asn Pro Ser Asn Gly Gly Thr Asn Tyr Asn Glu Lys Phe Lys 
        195                 200                 205             


Asn Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Ser Thr Ala Tyr Met 
    210                 215                 220                 


Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys Ala 
225                 230                 235                 240 


Arg Arg Asp Tyr Tyr Tyr Gly Ser Ser Tyr Gly Phe Asp Val Trp Gly 
                245                 250                 255     


Thr Gly Thr Thr Val Thr Val Ser Ser 
            260                 265 


<210>  45
<211>  780
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic - 10C2

<400>  45
atggccttac cagtgaccgc cttgctcctg ccgctggcct tgctgctcca cgccgccagg       60

ccgcaggtgc agctggagca gtctggacct gtgctggtga agcctggggc ttcagtgaag      120

atgtcctgta aggcttctgg atacacattc actgactact atatgaactg ggtgaagcag      180

agccatggaa agagccttga gtggattgga gttattaatc cttacaacgg tggtactagc      240

tacaaccaga agttcaaggg caaggccaca ttgactgttg acaagtcctc cagcacagcc      300

tgcatggagc tcaactgcct aacatctgag gactctgcag tctattactg taccctgggg      360

gcttactggg gtcaaggaac ctcagtcacc gtctcctcag gtggcggtgg ctcgggcggt      420

ggtgggtcgg gtggcggcgg atctgatatt gtgctgacac agactccact cactttgtcg      480

gttaccattg gacaaccagc ctccatctct tgcaagtcaa atcagagcct cttagatagt      540

tatggaaaga catatttgaa ttggttgtta cagaggccag gccagtctcc aaagcgccta      600

atctatctgg tgtctaaact ggactctgga gtccctgaca ggttcactgg cagtggatca      660

gggacagatt tcacactgaa aatcagcaga gtggaggctg aggatttggg agtttattat      720

tgctggcaag gtacacattt tcctcggacg ttcggtggag gcaccaagct ggaaatcaaa      780


<210>  46
<211>  260
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic - 10C2

<400>  46

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Gln Val Gln Leu Glu Gln Ser Gly Pro Val Leu 
            20                  25                  30          


Val Lys Pro Gly Ala Ser Val Lys Met Ser Cys Lys Ala Ser Gly Tyr 
        35                  40                  45              


Thr Phe Thr Asp Tyr Tyr Met Asn Trp Val Lys Gln Ser His Gly Lys 
    50                  55                  60                  


Ser Leu Glu Trp Ile Gly Val Ile Asn Pro Tyr Asn Gly Gly Thr Ser 
65                  70                  75                  80  


Tyr Asn Gln Lys Phe Lys Gly Lys Ala Thr Leu Thr Val Asp Lys Ser 
                85                  90                  95      


Ser Ser Thr Ala Cys Met Glu Leu Asn Cys Leu Thr Ser Glu Asp Ser 
            100                 105                 110         


Ala Val Tyr Tyr Cys Thr Leu Gly Ala Tyr Trp Gly Gln Gly Thr Ser 
        115                 120                 125             


Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
    130                 135                 140                 


Gly Gly Gly Ser Asp Ile Val Leu Thr Gln Thr Pro Leu Thr Leu Ser 
145                 150                 155                 160 


Val Thr Ile Gly Gln Pro Ala Ser Ile Ser Cys Lys Ser Asn Gln Ser 
                165                 170                 175     


Leu Leu Asp Ser Tyr Gly Lys Thr Tyr Leu Asn Trp Leu Leu Gln Arg 
            180                 185                 190         


Pro Gly Gln Ser Pro Lys Arg Leu Ile Tyr Leu Val Ser Lys Leu Asp 
        195                 200                 205             


Ser Gly Val Pro Asp Arg Phe Thr Gly Ser Gly Ser Gly Thr Asp Phe 
    210                 215                 220                 


Thr Leu Lys Ile Ser Arg Val Glu Ala Glu Asp Leu Gly Val Tyr Tyr 
225                 230                 235                 240 


Cys Trp Gln Gly Thr His Phe Pro Arg Thr Phe Gly Gly Gly Thr Lys 
                245                 250                 255     


Leu Glu Ile Lys 
            260 


<210>  47
<211>  790
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic - 12B1

<400>  47
atggccttac cagtgaccgc cttgctcctg ccgctggcct tgctgctcca cgccgccagg       60

ccggaggtca agctggagga gtcagggact gaactggtga agcctggggc ttcagtgaag      120

ctgtcctgca aggcttctgg ctacaccttc accagctact ggatgcactg ggtgaagcag      180

aggcctggac aaggccttga gtggattgga aatattaatc ctaccaatgg tggtactaac      240

tacaatgaga agttcaagag caaggccaca ctgactgtag acaaatcctc cagaacagcc      300

tacatgcagc tcagcagcct gacatctggg gactcagcgg tctactattg tgcaagaagg      360

gactttatta ctacatccgg gtttgcttac tggggccaag ggactctggt cactgtctct      420

gcaggtggcg gtggctcggg cggtggtggg tcgggtggcg gcggatctga tattgtgatg      480

acacagacta cagcctccct atctacatct gtgggagaaa ctgtcaccat cacatgtcga      540

gcaagtggga atcttcacag ttatttaaca tggtatcagc agaaacaggg aaagtctcct      600

cagctcctgg tctataatgc aaaaacctta gcagatggtg tgccatcaag gttcagtggc      660

agtggatcag gaacacaata ttctctcaag atcgacagcc tgcagcctga agattttggg      720

agttattact gtcaacattt ttggactact ccattcacgt tcggctcggg gacaaagttg      780

gagataaaac                                                             790


<210>  48
<211>  263
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic - 12B1

<400>  48

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Glu Val Lys Leu Glu Glu Ser Gly Thr Glu Leu 
            20                  25                  30          


Val Lys Pro Gly Ala Ser Val Lys Leu Ser Cys Lys Ala Ser Gly Tyr 
        35                  40                  45              


Thr Phe Thr Ser Tyr Trp Met His Trp Val Lys Gln Arg Pro Gly Gln 
    50                  55                  60                  


Gly Leu Glu Trp Ile Gly Asn Ile Asn Pro Thr Asn Gly Gly Thr Asn 
65                  70                  75                  80  


Tyr Asn Glu Lys Phe Lys Ser Lys Ala Thr Leu Thr Val Asp Lys Ser 
                85                  90                  95      


Ser Arg Thr Ala Tyr Met Gln Leu Ser Ser Leu Thr Ser Gly Asp Ser 
            100                 105                 110         


Ala Val Tyr Tyr Cys Ala Arg Arg Asp Phe Ile Thr Thr Ser Gly Phe 
        115                 120                 125             


Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ala Gly Gly Gly 
    130                 135                 140                 


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Val Met 
145                 150                 155                 160 


Thr Gln Thr Thr Ala Ser Leu Ser Thr Ser Val Gly Glu Thr Val Thr 
                165                 170                 175     


Ile Thr Cys Arg Ala Ser Gly Asn Leu His Ser Tyr Leu Thr Trp Tyr 
            180                 185                 190         


Gln Gln Lys Gln Gly Lys Ser Pro Gln Leu Leu Val Tyr Asn Ala Lys 
        195                 200                 205             


Thr Leu Ala Asp Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly 
    210                 215                 220                 


Thr Gln Tyr Ser Leu Lys Ile Asp Ser Leu Gln Pro Glu Asp Phe Gly 
225                 230                 235                 240 


Ser Tyr Tyr Cys Gln His Phe Trp Thr Thr Pro Phe Thr Phe Gly Ser 
                245                 250                 255     


Gly Thr Lys Leu Glu Ile Lys 
            260             


<210>  49
<211>  799
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic - 13H1

<400>  49
atggccttac cagtgaccgc cttgctcctg ccgctggcct tgctgctcca cgccgccagg       60

ccgcaagtcc agctgcagca gtctgggact gaactggtga agcctggggc ttcagtgaag      120

ctgtcctgca aggcttctgg ccacaccttc accagctact ggatgcactg ggtgaagcag      180

aggcctggac aaggccttga gtggattgga aatattaatc ctagcaatgg tggtactaac      240

tacaatgaga agttcaagag caaggccaca ctgactgtag acaaatcctc cagcacagcc      300

tacatgcagc tcagcagcct gacatctgag gactctgcgg tctattattg tgcaagaagg      360

ggatactacg gtagtagcag ctactggtcc ttcgatgtct ggggcacagg gaccacggtc      420

accgtctcct caggtggcgg tggctcgggc ggtggtgggt cgggtggcgg cggatctgac      480

attgtgatga cccagactcc caaatccatg tccatgtcag taggagagag ggtcaccttg      540

agctgcaagg ccagtgagaa tgtgggtact tatgtatcct ggtatcaaca gaaaccagag      600

cagtctccta aagtgctgat atacggggca tccaaccggt tcactggggt ccccgatcgc      660

ttcacaggca gtggatctgc aacagatttc actctgacca tcagtagtgt gcagactgag      720

gaccttgcag attatcactg tggacagagt tacagctatc cgctcacgtt cggtgctggg      780

accaagctgg agctgaaac                                                   799


<210>  50
<211>  266
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic - 13H1

<400>  50

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Gln Val Gln Leu Gln Gln Ser Gly Thr Glu Leu 
            20                  25                  30          


Val Lys Pro Gly Ala Ser Val Lys Leu Ser Cys Lys Ala Ser Gly His 
        35                  40                  45              


Thr Phe Thr Ser Tyr Trp Met His Trp Val Lys Gln Arg Pro Gly Gln 
    50                  55                  60                  


Gly Leu Glu Trp Ile Gly Asn Ile Asn Pro Ser Asn Gly Gly Thr Asn 
65                  70                  75                  80  


Tyr Asn Glu Lys Phe Lys Ser Lys Ala Thr Leu Thr Val Asp Lys Ser 
                85                  90                  95      


Ser Ser Thr Ala Tyr Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser 
            100                 105                 110         


Ala Val Tyr Tyr Cys Ala Arg Arg Gly Tyr Tyr Gly Ser Ser Ser Tyr 
        115                 120                 125             


Trp Ser Phe Asp Val Trp Gly Thr Gly Thr Thr Val Thr Val Ser Ser 
    130                 135                 140                 


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp 
145                 150                 155                 160 


Ile Val Met Thr Gln Thr Pro Lys Ser Met Ser Met Ser Val Gly Glu 
                165                 170                 175     


Arg Val Thr Leu Ser Cys Lys Ala Ser Glu Asn Val Gly Thr Tyr Val 
            180                 185                 190         


Ser Trp Tyr Gln Gln Lys Pro Glu Gln Ser Pro Lys Val Leu Ile Tyr 
        195                 200                 205             


Gly Ala Ser Asn Arg Phe Thr Gly Val Pro Asp Arg Phe Thr Gly Ser 
    210                 215                 220                 


Gly Ser Ala Thr Asp Phe Thr Leu Thr Ile Ser Ser Val Gln Thr Glu 
225                 230                 235                 240 


Asp Leu Ala Asp Tyr His Cys Gly Gln Ser Tyr Ser Tyr Pro Leu Thr 
                245                 250                 255     


Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys 
            260                 265     


<210>  51
<211>  793
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic - 15B8

<400>  51
atggccttac cagtgaccgc cttgctcctg ccgctggcct tgctgctcca cgccgccagg       60

ccgcaggttc agctggagca gtctgggact gaactggtga agcctggggc ttcagtgaag      120

ctgtcctgca aggcttctgg ctacaccttc accagctact ggatgcactg ggtgaagcag      180

aggcctggac aaggccttga gtggattgga aatattaatc ctagcaatgg tggtactaac      240

tacaatgaga agttcaagag caaggccaca ctgactgtag acaaatcctc cagcacagcc      300

tacatgcagc tcagcagcct gacatctgag gactctgcga tctattattg tgcaagacgg      360

aataattact acgctagtag cccttttgct tactggggcc aagggactct ggtcagtgtc      420

tctgcaggtg gcggtggctc gggcggtggt gggtcgggtg gcggcggatc tgacattgtg      480

atgacacaga ctccagcctc cctatctgca tctgtgggag aaactgtcac catcacatgt      540

cgagcaagtg ggaatattca caattattta gcatggtatc agcagaaaca gggaaaatct      600

cctcagctcc tggtctataa tgcaaaaacc ttagcagatg gtgtgccatc aaggttcagt      660

ggcagtggat caggaacaca atattctctc aagatcaaca gcctgcagcc tgaagatttt      720

gggagttatt actgtcaaca tttttggagt actccattca cgttcggctc ggggacaaag      780

ttggaaataa aac                                                         793


<210>  52
<211>  264
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic - 15B8

<400>  52

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Gln Val Gln Leu Glu Gln Ser Gly Thr Glu Leu 
            20                  25                  30          


Val Lys Pro Gly Ala Ser Val Lys Leu Ser Cys Lys Ala Ser Gly Tyr 
        35                  40                  45              


Thr Phe Thr Ser Tyr Trp Met His Trp Val Lys Gln Arg Pro Gly Gln 
    50                  55                  60                  


Gly Leu Glu Trp Ile Gly Asn Ile Asn Pro Ser Asn Gly Gly Thr Asn 
65                  70                  75                  80  


Tyr Asn Glu Lys Phe Lys Ser Lys Ala Thr Leu Thr Val Asp Lys Ser 
                85                  90                  95      


Ser Ser Thr Ala Tyr Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser 
            100                 105                 110         


Ala Ile Tyr Tyr Cys Ala Arg Arg Asn Asn Tyr Tyr Ala Ser Ser Pro 
        115                 120                 125             


Phe Ala Tyr Trp Gly Gln Gly Thr Leu Val Ser Val Ser Ala Gly Gly 
    130                 135                 140                 


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Val 
145                 150                 155                 160 


Met Thr Gln Thr Pro Ala Ser Leu Ser Ala Ser Val Gly Glu Thr Val 
                165                 170                 175     


Thr Ile Thr Cys Arg Ala Ser Gly Asn Ile His Asn Tyr Leu Ala Trp 
            180                 185                 190         


Tyr Gln Gln Lys Gln Gly Lys Ser Pro Gln Leu Leu Val Tyr Asn Ala 
        195                 200                 205             


Lys Thr Leu Ala Asp Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser 
    210                 215                 220                 


Gly Thr Gln Tyr Ser Leu Lys Ile Asn Ser Leu Gln Pro Glu Asp Phe 
225                 230                 235                 240 


Gly Ser Tyr Tyr Cys Gln His Phe Trp Ser Thr Pro Phe Thr Phe Gly 
                245                 250                 255     


Ser Gly Thr Lys Leu Glu Ile Lys 
            260                 


<210>  53
<211>  1467
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic - 8D10 CAR

<400>  53
atggccttac cagtgaccgc cttgctcctg ccgctggcct tgctgctcca cgccgccagg       60

ccgcaagtac agctgcagga gtctgggact gaactggtga agcctggggc ttcagtgaag      120

ctgtcctgca aggcttctgg ctacaccttc accagctact ggatgcactg gatgaagcag      180

aggcctggac aaggccttga gtggattgga aatattaatc ctagcaatgg tggtactaac      240

tacaatgaga agttcaagaa caaggccaca ctgactgtag acaaatcctc cagcacagcc      300

tacatgcagc tcagcagcct gacatctgag gactctgcgg tctattattg tgcaagaagg      360

gattattact acggtagtag ctacggcttc gatgtctggg gcacagggac cacggtcacc      420

gtctcctcag gtggcggtgg ctcgggcggt ggtgggtcgg gtggcggcgg atctgatatt      480

gtgatgaccc agtctcctgc ctcccagtct gcatctctgg gagaaagtgt caccatcaca      540

tgcctggcaa gtcagaccat tggtacatgg ttagcatggt atcagcagaa accagggaaa      600

tctcctcagt tcctgattta tgctgcaacc agcttggcag atggggtccc atcaaggttc      660

agtggtagtg gatctggcac aaaattttct ttcaagatca gcagcctaca ggctgaagat      720

tttgtaagtt attactgtca acaactttac agtactccgt tcacgttcgg aggggggacc      780

aagctggaaa taaaaaccac gacgccagcg ccgcgaccac caacaccggc gcccaccatc      840

gcgtcgcagc ccctgtccct gcgcccagag gcgtgccggc cagcggcggg gggcgcagtg      900

cacacgaggg ggctggactt cgcctgtgat atctacatct gggcgccctt ggccgggact      960

tgtggggtcc ttctcctgtc actggttatc accctttact gcaaacgggg cagaaagaaa     1020

ctcctgtata tattcaaaca accatttatg agaccagtac aaactactca agaggaagat     1080

ggctgtagct gccgatttcc agaagaagaa gaaggaggat gtgaactgag agtgaagttc     1140

agcaggagcg cagacgcccc cgcgtacaag cagggccaga accagctcta taacgagctc     1200

aatctaggac gaagagagga gtacgatgtt ttggacaaga gacgtggccg ggaccctgag     1260

atggggggaa agccgagaag gaagaaccct caggaaggcc tgtacaatga actgcagaaa     1320

gataagatgg cggaggccta cagtgagatt gggatgaaag gcgagcgccg gaggggcaag     1380

gggcacgatg gcctttacca gggtctcagt acagccacca aggacaccta cgacgccctt     1440

cacatgcagg ccctgccccc tcgctag                                         1467


<210>  54
<211>  488
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic - 8D10 CAR

<400>  54

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Gln Val Gln Leu Gln Glu Ser Gly Thr Glu Leu 
            20                  25                  30          


Val Lys Pro Gly Ala Ser Val Lys Leu Ser Cys Lys Ala Ser Gly Tyr 
        35                  40                  45              


Thr Phe Thr Ser Tyr Trp Met His Trp Met Lys Gln Arg Pro Gly Gln 
    50                  55                  60                  


Gly Leu Glu Trp Ile Gly Asn Ile Asn Pro Ser Asn Gly Gly Thr Asn 
65                  70                  75                  80  


Tyr Asn Glu Lys Phe Lys Asn Lys Ala Thr Leu Thr Val Asp Lys Ser 
                85                  90                  95      


Ser Ser Thr Ala Tyr Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser 
            100                 105                 110         


Ala Val Tyr Tyr Cys Ala Arg Arg Asp Tyr Tyr Tyr Gly Ser Ser Tyr 
        115                 120                 125             


Gly Phe Asp Val Trp Gly Thr Gly Thr Thr Val Thr Val Ser Ser Gly 
    130                 135                 140                 


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile 
145                 150                 155                 160 


Val Met Thr Gln Ser Pro Ala Ser Gln Ser Ala Ser Leu Gly Glu Ser 
                165                 170                 175     


Val Thr Ile Thr Cys Leu Ala Ser Gln Thr Ile Gly Thr Trp Leu Ala 
            180                 185                 190         


Trp Tyr Gln Gln Lys Pro Gly Lys Ser Pro Gln Phe Leu Ile Tyr Ala 
        195                 200                 205             


Ala Thr Ser Leu Ala Asp Gly Val Pro Ser Arg Phe Ser Gly Ser Gly 
    210                 215                 220                 


Ser Gly Thr Lys Phe Ser Phe Lys Ile Ser Ser Leu Gln Ala Glu Asp 
225                 230                 235                 240 


Phe Val Ser Tyr Tyr Cys Gln Gln Leu Tyr Ser Thr Pro Phe Thr Phe 
                245                 250                 255     


Gly Gly Gly Thr Lys Leu Glu Ile Lys Thr Thr Thr Pro Ala Pro Arg 
            260                 265                 270         


Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg 
        275                 280                 285             


Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala Val His Thr Arg Gly 
    290                 295                 300                 


Leu Asp Phe Ala Cys Asp Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr 
305                 310                 315                 320 


Cys Gly Val Leu Leu Leu Ser Leu Val Ile Thr Leu Tyr Cys Lys Arg 
                325                 330                 335     


Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met Arg Pro 
            340                 345                 350         


Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe Pro Glu 
        355                 360                 365             


Glu Glu Glu Gly Gly Cys Glu Leu Arg Val Lys Phe Ser Arg Ser Ala 
    370                 375                 380                 


Asp Ala Pro Ala Tyr Lys Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu 
385                 390                 395                 400 


Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly 
                405                 410                 415     


Arg Asp Pro Glu Met Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu 
            420                 425                 430         


Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser 
        435                 440                 445             


Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly 
    450                 455                 460                 


Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu 
465                 470                 475                 480 


His Met Gln Ala Leu Pro Pro Arg 
                485             


<210>  55
<211>  672
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  55
accacgacgc cagcgccgcg accaccaaca ccggcgccca ccatcgcgtc gcagcccctg       60

tccctgcgcc cagaggcgtg ccggccagcg gcggggggcg cagtgcacac gagggggctg      120

gacttcgcct gtgatatcta catctgggcg cccttggccg ggacttgtgg ggtccttctc      180

ctgtcactgg ttatcaccct ttactgcaaa cggggcagaa agaaactcct gtatatattc      240

aaacaaccat ttatgagacc agtacaaact actcaagagg aagatggctg tagctgccga      300

tttccagaag aagaagaagg aggatgtgaa ctgagagtga agttcagcag gagcgcagac      360

gcccccgcgt acaagcaggg ccagaaccag ctctataacg agctcaatct aggacgaaga      420

gaggagtacg atgttttgga caagagacgt ggccgggacc ctgagatggg gggaaagccg      480

agaaggaaga accctcagga aggcctgtac aatgaactgc agaaagataa gatggcggag      540

gcctacagtg agattgggat gaaaggcgag cgccggaggg gcaaggggca cgatggcctt      600

taccagggtc tcagtacagc caccaaggac acctacgacg cccttcacat gcaggccctg      660

ccccctcgct ag                                                          672


<210>  56
<211>  223
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  56

Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala 
1               5                   10                  15      


Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly 
            20                  25                  30          


Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp Ile Tyr Ile 
        35                  40                  45              


Trp Ala Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu Ser Leu Val 
    50                  55                  60                  


Ile Thr Leu Tyr Cys Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe 
65                  70                  75                  80  


Lys Gln Pro Phe Met Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly 
                85                  90                  95      


Cys Ser Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu Arg 
            100                 105                 110         


Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Lys Gln Gly Gln 
        115                 120                 125             


Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp 
    130                 135                 140                 


Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro 
145                 150                 155                 160 


Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp 
                165                 170                 175     


Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg 
            180                 185                 190         


Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr 
        195                 200                 205             


Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
    210                 215                 220             


