                         SEQUENCE LISTING

<110>  NEW YORK UNIVERSITY
       UNITED STATES GOVERNMENT AS REPRESENTED BY THE DEPARTMENT 
       OF VETERANS AFFAIRS
       Castillo, Alesha
       Montclare, Jin  Kim
       Punia, Kamia
 
<120>  Compositions and Methods for use of CXCL12 in Treatment of Bone 
       Disorders

<130>  206256-0014-00WO

<150>  62/737,164
<151>  2018-09-27

<160>  22    

<170>  PatentIn version 3.5

<210>  1
<211>  68
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CXCL12

<400>  1

Lys Pro Val Ser Leu Ser Tyr Arg Cys Pro Cys Arg Phe Phe Glu Ser 
1               5                   10                  15      


His Val Ala Arg Ala Asn Val Lys His Leu Lys Ile Leu Asn Thr Pro 
            20                  25                  30          


Asn Cys Ala Leu Gln Ile Val Ala Arg Leu Lys Asn Asn Asn Arg Gln 
        35                  40                  45              


Val Cys Ile Asp Pro Lys Leu Lys Trp Ile Gln Glu Tyr Leu Glu Lys 
    50                  55                  60                  


Ala Leu Asn Lys 
65              


<210>  2
<211>  68
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CXCL12

<400>  2

Lys Pro Val Cys Leu Cys Tyr Arg Cys Pro Cys Arg Phe Phe Glu Ser 
1               5                   10                  15      


His Val Ala Arg Ala Asn Val Lys His Leu Lys Ile Leu Asn Thr Pro 
            20                  25                  30          


Asn Cys Ala Leu Gln Ile Val Ala Arg Leu Lys Asn Asn Asn Arg Gln 
        35                  40                  45              


Val Cys Ile Asp Pro Lys Leu Lys Trp Ile Gln Glu Tyr Leu Glu Lys 
    50                  55                  60                  


Ala Leu Asn Lys 
65              


<210>  3
<211>  68
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CXCL12

<400>  3

Lys Pro Leu Cys Val Cys Tyr Arg Cys Pro Cys Arg Phe Phe Glu Ser 
1               5                   10                  15      


His Val Ala Arg Ala Asn Val Lys His Leu Lys Ile Leu Asn Thr Pro 
            20                  25                  30          


Asn Cys Ala Leu Gln Ile Val Ala Arg Leu Lys Asn Asn Asn Arg Gln 
        35                  40                  45              


Val Cys Ile Asp Pro Lys Leu Lys Trp Ile Gln Glu Tyr Leu Glu Lys 
    50                  55                  60                  


Ala Leu Asn Lys 
65              


<210>  4
<211>  21
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  signal peptide

<400>  4

Met Asn Ala Lys Val Val Val Val Leu Val Leu Val Leu Thr Ala Leu 
1               5                   10                  15      


Cys Leu Ser Asp Gly 
            20      


<210>  5
<211>  69
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CXCL12 fusion


<220>
<221>  misc_feature
<222>  (69)..(69)
<223>  Xaa can be any naturally occurring amino acid

<400>  5

Lys Pro Val Ser Leu Ser Tyr Arg Cys Pro Cys Arg Phe Phe Glu Ser 
1               5                   10                  15      


His Val Ala Arg Ala Asn Val Lys His Leu Lys Ile Leu Asn Thr Pro 
            20                  25                  30          


Asn Cys Ala Leu Gln Ile Val Ala Arg Leu Lys Asn Asn Asn Arg Gln 
        35                  40                  45              


Val Cys Ile Asp Pro Lys Leu Lys Trp Ile Gln Glu Tyr Leu Glu Lys 
    50                  55                  60                  


Ala Leu Asn Lys Xaa 
65                  


<210>  6
<211>  69
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CXCL12 fusion


<220>
<221>  misc_feature
<222>  (69)..(69)
<223>  Xaa can be any naturally occurring amino acid

<400>  6

Lys Pro Val Cys Leu Cys Tyr Arg Cys Pro Cys Arg Phe Phe Glu Ser 
1               5                   10                  15      


His Val Ala Arg Ala Asn Val Lys His Leu Lys Ile Leu Asn Thr Pro 
            20                  25                  30          


Asn Cys Ala Leu Gln Ile Val Ala Arg Leu Lys Asn Asn Asn Arg Gln 
        35                  40                  45              


Val Cys Ile Asp Pro Lys Leu Lys Trp Ile Gln Glu Tyr Leu Glu Lys 
    50                  55                  60                  


Ala Leu Asn Lys Xaa 
65                  


<210>  7
<211>  69
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CXCL12 fusion


<220>
<221>  misc_feature
<222>  (69)..(69)
<223>  Xaa can be any naturally occurring amino acid

<400>  7

Lys Pro Leu Cys Val Cys Tyr Arg Cys Pro Cys Arg Phe Phe Glu Ser 
1               5                   10                  15      


His Val Ala Arg Ala Asn Val Lys His Leu Lys Ile Leu Asn Thr Pro 
            20                  25                  30          


Asn Cys Ala Leu Gln Ile Val Ala Arg Leu Lys Asn Asn Asn Arg Gln 
        35                  40                  45              


Val Cys Ile Asp Pro Lys Leu Lys Trp Ile Gln Glu Tyr Leu Glu Lys 
    50                  55                  60                  


Ala Leu Asn Lys Xaa 
65                  


<210>  8
<211>  90
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CXCL12 fusion


<220>
<221>  misc_feature
<222>  (90)..(90)
<223>  Xaa can be any naturally occurring amino acid

<400>  8

Met Asn Ala Lys Val Val Val Val Leu Val Leu Val Leu Thr Ala Leu 
1               5                   10                  15      


Cys Leu Ser Asp Gly Lys Pro Val Ser Leu Ser Tyr Arg Cys Pro Cys 
            20                  25                  30          


Arg Phe Phe Glu Ser His Val Ala Arg Ala Asn Val Lys His Leu Lys 
        35                  40                  45              


Ile Leu Asn Thr Pro Asn Cys Ala Leu Gln Ile Val Ala Arg Leu Lys 
    50                  55                  60                  


Asn Asn Asn Arg Gln Val Cys Ile Asp Pro Lys Leu Lys Trp Ile Gln 
65                  70                  75                  80  


Glu Tyr Leu Glu Lys Ala Leu Asn Lys Xaa 
                85                  90  


<210>  9
<211>  90
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CXCL12 fusion


<220>
<221>  misc_feature
<222>  (90)..(90)
<223>  Xaa can be any naturally occurring amino acid

<400>  9

Met Asn Ala Lys Val Val Val Val Leu Val Leu Val Leu Thr Ala Leu 
1               5                   10                  15      


Cys Leu Ser Asp Gly Lys Pro Val Cys Leu Cys Tyr Arg Cys Pro Cys 
            20                  25                  30          


Arg Phe Phe Glu Ser His Val Ala Arg Ala Asn Val Lys His Leu Lys 
        35                  40                  45              


Ile Leu Asn Thr Pro Asn Cys Ala Leu Gln Ile Val Ala Arg Leu Lys 
    50                  55                  60                  


Asn Asn Asn Arg Gln Val Cys Ile Asp Pro Lys Leu Lys Trp Ile Gln 
65                  70                  75                  80  


Glu Tyr Leu Glu Lys Ala Leu Asn Lys Xaa 
                85                  90  


<210>  10
<211>  90
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CXCL12 fusion


<220>
<221>  misc_feature
<222>  (90)..(90)
<223>  Xaa can be any naturally occurring amino acid

<400>  10

Met Asn Ala Lys Val Val Val Val Leu Val Leu Val Leu Thr Ala Leu 
1               5                   10                  15      


Cys Leu Ser Asp Gly Lys Pro Leu Cys Val Cys Tyr Arg Cys Pro Cys 
            20                  25                  30          


Arg Phe Phe Glu Ser His Val Ala Arg Ala Asn Val Lys His Leu Lys 
        35                  40                  45              


Ile Leu Asn Thr Pro Asn Cys Ala Leu Gln Ile Val Ala Arg Leu Lys 
    50                  55                  60                  


Asn Asn Asn Arg Gln Val Cys Ile Asp Pro Lys Leu Lys Trp Ile Gln 
65                  70                  75                  80  


Glu Tyr Leu Glu Lys Ala Leu Asn Lys Xaa 
                85                  90  


<210>  11
<211>  69
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CXCL12 fusion


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<400>  11

Xaa Lys Pro Val Ser Leu Ser Tyr Arg Cys Pro Cys Arg Phe Phe Glu 
1               5                   10                  15      


Ser His Val Ala Arg Ala Asn Val Lys His Leu Lys Ile Leu Asn Thr 
            20                  25                  30          


Pro Asn Cys Ala Leu Gln Ile Val Ala Arg Leu Lys Asn Asn Asn Arg 
        35                  40                  45              


Gln Val Cys Ile Asp Pro Lys Leu Lys Trp Ile Gln Glu Tyr Leu Glu 
    50                  55                  60                  


Lys Ala Leu Asn Lys 
65                  


<210>  12
<211>  69
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CXCL12 fusion


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<400>  12

Xaa Lys Pro Val Cys Leu Cys Tyr Arg Cys Pro Cys Arg Phe Phe Glu 
1               5                   10                  15      


Ser His Val Ala Arg Ala Asn Val Lys His Leu Lys Ile Leu Asn Thr 
            20                  25                  30          


Pro Asn Cys Ala Leu Gln Ile Val Ala Arg Leu Lys Asn Asn Asn Arg 
        35                  40                  45              


Gln Val Cys Ile Asp Pro Lys Leu Lys Trp Ile Gln Glu Tyr Leu Glu 
    50                  55                  60                  


Lys Ala Leu Asn Lys 
65                  


<210>  13
<211>  69
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CXCL12 fusion


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<400>  13

Xaa Lys Pro Leu Cys Val Cys Tyr Arg Cys Pro Cys Arg Phe Phe Glu 
1               5                   10                  15      


Ser His Val Ala Arg Ala Asn Val Lys His Leu Lys Ile Leu Asn Thr 
            20                  25                  30          


Pro Asn Cys Ala Leu Gln Ile Val Ala Arg Leu Lys Asn Asn Asn Arg 
        35                  40                  45              


Gln Val Cys Ile Asp Pro Lys Leu Lys Trp Ile Gln Glu Tyr Leu Glu 
    50                  55                  60                  


Lys Ala Leu Asn Lys 
65                  


<210>  14
<211>  90
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CXCL12 fusion


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<400>  14

Xaa Met Asn Ala Lys Val Val Val Val Leu Val Leu Val Leu Thr Ala 
1               5                   10                  15      


Leu Cys Leu Ser Asp Gly Lys Pro Val Ser Leu Ser Tyr Arg Cys Pro 
            20                  25                  30          


Cys Arg Phe Phe Glu Ser His Val Ala Arg Ala Asn Val Lys His Leu 
        35                  40                  45              


Lys Ile Leu Asn Thr Pro Asn Cys Ala Leu Gln Ile Val Ala Arg Leu 
    50                  55                  60                  


Lys Asn Asn Asn Arg Gln Val Cys Ile Asp Pro Lys Leu Lys Trp Ile 
65                  70                  75                  80  


Gln Glu Tyr Leu Glu Lys Ala Leu Asn Lys 
                85                  90  


<210>  15
<211>  90
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CXCL12 fusion


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<400>  15

Xaa Met Asn Ala Lys Val Val Val Val Leu Val Leu Val Leu Thr Ala 
1               5                   10                  15      


Leu Cys Leu Ser Asp Gly Lys Pro Val Cys Leu Cys Tyr Arg Cys Pro 
            20                  25                  30          


Cys Arg Phe Phe Glu Ser His Val Ala Arg Ala Asn Val Lys His Leu 
        35                  40                  45              


Lys Ile Leu Asn Thr Pro Asn Cys Ala Leu Gln Ile Val Ala Arg Leu 
    50                  55                  60                  


Lys Asn Asn Asn Arg Gln Val Cys Ile Asp Pro Lys Leu Lys Trp Ile 
65                  70                  75                  80  


Gln Glu Tyr Leu Glu Lys Ala Leu Asn Lys 
                85                  90  


<210>  16
<211>  90
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CXCL12 fusion


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<400>  16

Xaa Met Asn Ala Lys Val Val Val Val Leu Val Leu Val Leu Thr Ala 
1               5                   10                  15      


Leu Cys Leu Ser Asp Gly Lys Pro Leu Cys Val Cys Tyr Arg Cys Pro 
            20                  25                  30          


Cys Arg Phe Phe Glu Ser His Val Ala Arg Ala Asn Val Lys His Leu 
        35                  40                  45              


Lys Ile Leu Asn Thr Pro Asn Cys Ala Leu Gln Ile Val Ala Arg Leu 
    50                  55                  60                  


Lys Asn Asn Asn Arg Gln Val Cys Ile Asp Pro Lys Leu Lys Trp Ile 
65                  70                  75                  80  


Gln Glu Tyr Leu Glu Lys Ala Leu Asn Lys 
                85                  90  


<210>  17
<211>  70
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CXCL12 fusion precurosr


<220>
<221>  misc_feature
<222>  (70)..(70)
<223>  Xaa can be any naturally occurring amino acid

<400>  17

Lys Pro Val Ser Leu Ser Tyr Arg Cys Pro Cys Arg Phe Phe Glu Ser 
1               5                   10                  15      


His Val Ala Arg Ala Asn Val Lys His Leu Lys Ile Leu Asn Thr Pro 
            20                  25                  30          


Asn Cys Ala Leu Gln Ile Val Ala Arg Leu Lys Asn Asn Asn Arg Gln 
        35                  40                  45              


Val Cys Ile Asp Pro Lys Leu Lys Trp Ile Gln Glu Tyr Leu Glu Lys 
    50                  55                  60                  


Ala Leu Asn Lys Met Xaa 
65                  70  


<210>  18
<211>  70
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CXCL12 fusion precurosr


<220>
<221>  misc_feature
<222>  (70)..(70)
<223>  Xaa can be any naturally occurring amino acid

<400>  18

Lys Pro Val Cys Leu Cys Tyr Arg Cys Pro Cys Arg Phe Phe Glu Ser 
1               5                   10                  15      


His Val Ala Arg Ala Asn Val Lys His Leu Lys Ile Leu Asn Thr Pro 
            20                  25                  30          


Asn Cys Ala Leu Gln Ile Val Ala Arg Leu Lys Asn Asn Asn Arg Gln 
        35                  40                  45              


Val Cys Ile Asp Pro Lys Leu Lys Trp Ile Gln Glu Tyr Leu Glu Lys 
    50                  55                  60                  


Ala Leu Asn Lys Met Xaa 
65                  70  


<210>  19
<211>  70
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CXCL12 fusion precurosr


<220>
<221>  misc_feature
<222>  (70)..(70)
<223>  Xaa can be any naturally occurring amino acid

<400>  19

Lys Pro Leu Cys Val Cys Tyr Arg Cys Pro Cys Arg Phe Phe Glu Ser 
1               5                   10                  15      


His Val Ala Arg Ala Asn Val Lys His Leu Lys Ile Leu Asn Thr Pro 
            20                  25                  30          


Asn Cys Ala Leu Gln Ile Val Ala Arg Leu Lys Asn Asn Asn Arg Gln 
        35                  40                  45              


Val Cys Ile Asp Pro Lys Leu Lys Trp Ile Gln Glu Tyr Leu Glu Lys 
    50                  55                  60                  


Ala Leu Asn Lys Met Xaa 
65                  70  


<210>  20
<211>  91
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CXCL12 fusion precurosr


<220>
<221>  misc_feature
<222>  (91)..(91)
<223>  Xaa can be any naturally occurring amino acid

<400>  20

Met Asn Ala Lys Val Val Val Val Leu Val Leu Val Leu Thr Ala Leu 
1               5                   10                  15      


Cys Leu Ser Asp Gly Lys Pro Val Ser Leu Ser Tyr Arg Cys Pro Cys 
            20                  25                  30          


Arg Phe Phe Glu Ser His Val Ala Arg Ala Asn Val Lys His Leu Lys 
        35                  40                  45              


Ile Leu Asn Thr Pro Asn Cys Ala Leu Gln Ile Val Ala Arg Leu Lys 
    50                  55                  60                  


Asn Asn Asn Arg Gln Val Cys Ile Asp Pro Lys Leu Lys Trp Ile Gln 
65                  70                  75                  80  


Glu Tyr Leu Glu Lys Ala Leu Asn Lys Met Xaa 
                85                  90      


<210>  21
<211>  91
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CXCL12 fusion precurosr


<220>
<221>  misc_feature
<222>  (91)..(91)
<223>  Xaa can be any naturally occurring amino acid

<400>  21

Met Asn Ala Lys Val Val Val Val Leu Val Leu Val Leu Thr Ala Leu 
1               5                   10                  15      


Cys Leu Ser Asp Gly Lys Pro Val Cys Leu Cys Tyr Arg Cys Pro Cys 
            20                  25                  30          


Arg Phe Phe Glu Ser His Val Ala Arg Ala Asn Val Lys His Leu Lys 
        35                  40                  45              


Ile Leu Asn Thr Pro Asn Cys Ala Leu Gln Ile Val Ala Arg Leu Lys 
    50                  55                  60                  


Asn Asn Asn Arg Gln Val Cys Ile Asp Pro Lys Leu Lys Trp Ile Gln 
65                  70                  75                  80  


Glu Tyr Leu Glu Lys Ala Leu Asn Lys Met Xaa 
                85                  90      


<210>  22
<211>  90
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CXCL12 fusion precurosr

<400>  22

Met Asn Ala Lys Val Val Val Val Leu Val Leu Val Leu Thr Ala Leu 
1               5                   10                  15      


Cys Leu Ser Asp Gly Lys Pro Leu Cys Val Cys Tyr Arg Cys Pro Cys 
            20                  25                  30          


Arg Phe Phe Glu Ser His Val Ala Arg Ala Asn Val Lys His Leu Lys 
        35                  40                  45              


Ile Leu Asn Thr Pro Asn Cys Ala Leu Gln Ile Val Ala Arg Leu Lys 
    50                  55                  60                  


Asn Asn Asn Arg Gln Val Cys Ile Asp Pro Lys Leu Lys Trp Ile Gln 
65                  70                  75                  80  


Glu Tyr Leu Glu Lys Ala Leu Asn Lys Met 
                85                  90  


