               SEQUENCE LISTING

<110> Leibniz Universität Hannover

<120> Analyseverfahren für mRNA einzeln lichtbestrahlter Zellen

<130> H1025PCT

<150> DE102018216872.5
<151> 2018-10-01

<160> 6

<170> BiSSAP 1.3.6

<210> 1
<211> 86
<212> PRT
<213> Artificial Sequence


<220> 
<223> N-terminal section of CRE

<400> 1
Thr Ser Asp Glu Val Arg Lys Asn Leu Met Asp Met Phe Arg Asp Arg 
1               5                   10                  15      
Gln Ala Phe Ser Glu His Thr Trp Lys Met Leu Leu Ser Val Cys Arg 
            20                  25                  30          
Ser Trp Ala Ala Trp Cys Lys Leu Asn Asn Arg Lys Trp Phe Pro Ala 
        35                  40                  45              
Glu Pro Glu Asp Val Arg Asp Tyr Leu Leu Tyr Leu Gln Ala Arg Gly 
    50                  55                  60                  
Leu Ala Val Lys Thr Ile Gln Gln His Leu Gly Gln Leu Asn Met Leu 
65                  70                  75                  80  
His Arg Arg Ser Gly Leu 
                85      

<210> 2
<211> 238
<212> PRT
<213> Artificial Sequence


<220> 
<223> C-terminal section of CRE

<400> 2
Arg Pro Ser Asp Ser Asn Ala Val Ser Leu Val Met Arg Arg Ile Arg 
1               5                   10                  15      
Lys Glu Asn Val Asp Ala Gly Glu Arg Ala Lys Gln Ala Leu Ala Phe 
            20                  25                  30          
Glu Arg Thr Asp Phe Asp Gln Val Arg Ser Leu Met Glu Asn Ser Asp 
        35                  40                  45              
Arg Cys Gln Asp Ile Arg Asn Leu Ala Phe Leu Gly Ile Ala Tyr Asn 
    50                  55                  60                  
Thr Leu Leu Arg Ile Ala Glu Ile Ala Arg Ile Arg Val Lys Asp Ile 
65                  70                  75                  80  
Ser Arg Thr Asp Gly Gly Arg Met Leu Ile His Ile Gly Arg Thr Lys 
                85                  90                  95      
Thr Leu Val Ser Thr Ala Gly Val Glu Lys Ala Leu Ser Leu Gly Val 
            100                 105                 110         
Thr Lys Leu Val Glu Arg Trp Ile Ser Val Ser Gly Val Ala Asp Asp 
        115                 120                 125             
Pro Asn Asn Tyr Leu Phe Cys Arg Val Arg Lys Asn Gly Val Ala Ala 
    130                 135                 140                 
Pro Ser Ala Thr Ser Gln Leu Ser Thr Arg Ala Leu Glu Gly Ile Phe 
145                 150                 155                 160 
Glu Ala Thr His Arg Leu Ile Tyr Gly Ala Lys Asp Asp Ser Gly Gln 
                165                 170                 175     
Arg Tyr Leu Ala Trp Ser Gly His Ser Ala Arg Val Gly Ala Ala Arg 
            180                 185                 190         
Asp Met Ala Arg Ala Gly Val Ser Ile Pro Glu Ile Met Gln Ala Gly 
        195                 200                 205             
Gly Trp Thr Asn Val Asn Ile Val Met Asn Tyr Ile Arg Asn Leu Asp 
    210                 215                 220                 
Ser Glu Thr Gly Ala Met Val Arg Leu Leu Glu Asp Gly Asp 
225                 230                 235             

<210> 3
<211> 1275
<212> DNA
<213> Artificial Sequence


<220> 
<223> Coding sequence for fusion protein of N-terminal CIB and
      C-terminal Cre

<220> 
<221> CDS
<222> 1..1275
<223> /product="fusion protein of N-terminal CIB and C-terminal Cre"
      /transl_table=1

<400> 3
atg aat gga gct ata gga ggt gac ctt ttg ctc aat ttt cct gac atg      48
Met Asn Gly Ala Ile Gly Gly Asp Leu Leu Leu Asn Phe Pro Asp Met 
1               5                   10                  15      

tcg gtc cta gag cgc caa agg gct cac ctc aag tac ctc aat ccc acc      96
Ser Val Leu Glu Arg Gln Arg Ala His Leu Lys Tyr Leu Asn Pro Thr 
            20                  25                  30          

ttt gat tct cct ctc gcc ggc ttc ttt gcc gat tct tca atg att acc     144
Phe Asp Ser Pro Leu Ala Gly Phe Phe Ala Asp Ser Ser Met Ile Thr 
        35                  40                  45              

ggc ggc gag atg gac agc tat ctt tcg act gcc ggt ttg aat ctt ccg     192
Gly Gly Glu Met Asp Ser Tyr Leu Ser Thr Ala Gly Leu Asn Leu Pro 
    50                  55                  60                  

atg atg tac ggt gag acg acg gtg gaa ggt gat tca aga ctc tca att     240
Met Met Tyr Gly Glu Thr Thr Val Glu Gly Asp Ser Arg Leu Ser Ile 
65                  70                  75                  80  

tcg ccg gaa acg acg ctt ggg act gga aat ttc aag aaa cgg aag ttt     288
Ser Pro Glu Thr Thr Leu Gly Thr Gly Asn Phe Lys Lys Arg Lys Phe 
                85                  90                  95      

gat aca gag act aag gat tgt aat gag aag aag aag aag atg acg atg     336
Asp Thr Glu Thr Lys Asp Cys Asn Glu Lys Lys Lys Lys Met Thr Met 
            100                 105                 110         

aac aga gat gac cta gta gaa gaa gga gaa gaa gag aag tcg aaa ata     384
Asn Arg Asp Asp Leu Val Glu Glu Gly Glu Glu Glu Lys Ser Lys Ile 
        115                 120                 125             

aca gag caa aac aat ggg agc aca aaa agc atc aag aag atg aaa cac     432
Thr Glu Gln Asn Asn Gly Ser Thr Lys Ser Ile Lys Lys Met Lys His 
    130                 135                 140                 

aaa gcc aag aaa gaa gag aac aat ttc tct aat gat tca tct aaa gtg     480
Lys Ala Lys Lys Glu Glu Asn Asn Phe Ser Asn Asp Ser Ser Lys Val 
145                 150                 155                 160 

acg aag gaa ttg gag aaa acg gat tat att cat ggt ggc ggt ggc tct     528
Thr Lys Glu Leu Glu Lys Thr Asp Tyr Ile His Gly Gly Gly Gly Ser 
                165                 170                 175     

gga ggt ggt ggg tcc gga gga ggc ggc cgc cga cca agt gac agc aat     576
Gly Gly Gly Gly Ser Gly Gly Gly Gly Arg Arg Pro Ser Asp Ser Asn 
            180                 185                 190         

gct gtt tca ctg gtt atg cgg cgg atc cga aaa gaa aac gtt gat gcc     624
Ala Val Ser Leu Val Met Arg Arg Ile Arg Lys Glu Asn Val Asp Ala 
        195                 200                 205             

ggt gaa cgt gca aaa cag gct cta gcg ttc gaa cgc act gat ttc gac     672
Gly Glu Arg Ala Lys Gln Ala Leu Ala Phe Glu Arg Thr Asp Phe Asp 
    210                 215                 220                 

cag gtt cgt tca ctc atg gaa aat agc gat cgc tgc cag gat ata cgt     720
Gln Val Arg Ser Leu Met Glu Asn Ser Asp Arg Cys Gln Asp Ile Arg 
225                 230                 235                 240 

aat ctg gca ttt ctg ggg att gct tat aac acc ctg tta cgt ata gcc     768
Asn Leu Ala Phe Leu Gly Ile Ala Tyr Asn Thr Leu Leu Arg Ile Ala 
                245                 250                 255     

gaa att gcc agg atc agg gtt aaa gat atc tca cgt act gac ggt ggg     816
Glu Ile Ala Arg Ile Arg Val Lys Asp Ile Ser Arg Thr Asp Gly Gly 
            260                 265                 270         

aga atg tta atc cat att ggc aga acg aaa acg ctg gtt agc acc gca     864
Arg Met Leu Ile His Ile Gly Arg Thr Lys Thr Leu Val Ser Thr Ala 
        275                 280                 285             

ggt gta gag aag gca ctt agc ctg ggg gta act aaa ctg gtc gag cga     912
Gly Val Glu Lys Ala Leu Ser Leu Gly Val Thr Lys Leu Val Glu Arg 
    290                 295                 300                 

tgg att tcc gtc tct ggt gta gct gat gat ccg aat aac tac ctg ttt     960
Trp Ile Ser Val Ser Gly Val Ala Asp Asp Pro Asn Asn Tyr Leu Phe 
305                 310                 315                 320 

tgc cgg gtc aga aaa aat ggt gtt gcc gcg cca tct gcc acc agc cag    1008
Cys Arg Val Arg Lys Asn Gly Val Ala Ala Pro Ser Ala Thr Ser Gln 
                325                 330                 335     

cta tca act cgc gcc ctg gaa ggg att ttt gaa gca act cat cga ttg    1056
Leu Ser Thr Arg Ala Leu Glu Gly Ile Phe Glu Ala Thr His Arg Leu 
            340                 345                 350         

att tac ggc gct aag gat gac tct ggt cag aga tac ctg gcc tgg tct    1104
Ile Tyr Gly Ala Lys Asp Asp Ser Gly Gln Arg Tyr Leu Ala Trp Ser 
        355                 360                 365             

gga cac agt gcc cgt gtc gga gcc gcg cga gat atg gcc cgc gct gga    1152
Gly His Ser Ala Arg Val Gly Ala Ala Arg Asp Met Ala Arg Ala Gly 
    370                 375                 380                 

gtt tca ata ccg gag atc atg caa gct ggt ggc tgg acc aat gta aat    1200
Val Ser Ile Pro Glu Ile Met Gln Ala Gly Gly Trp Thr Asn Val Asn 
385                 390                 395                 400 

att gtc atg aac tat atc cgt aac ctg gat agt gaa aca ggg gca atg    1248
Ile Val Met Asn Tyr Ile Arg Asn Leu Asp Ser Glu Thr Gly Ala Met 
                405                 410                 415     

gtg cgc ctg ctg gaa gat ggc gat tag                                1275
Val Arg Leu Leu Glu Asp Gly Asp     
            420                     

<210> 4
<211> 424
<212> PRT
<213> Artificial Sequence


<220> 
<223> [CDS]:1..1275 from SEQ ID NO 3

<400> 4
Met Asn Gly Ala Ile Gly Gly Asp Leu Leu Leu Asn Phe Pro Asp Met 
1               5                   10                  15      
Ser Val Leu Glu Arg Gln Arg Ala His Leu Lys Tyr Leu Asn Pro Thr 
            20                  25                  30          
Phe Asp Ser Pro Leu Ala Gly Phe Phe Ala Asp Ser Ser Met Ile Thr 
        35                  40                  45              
Gly Gly Glu Met Asp Ser Tyr Leu Ser Thr Ala Gly Leu Asn Leu Pro 
    50                  55                  60                  
Met Met Tyr Gly Glu Thr Thr Val Glu Gly Asp Ser Arg Leu Ser Ile 
65                  70                  75                  80  
Ser Pro Glu Thr Thr Leu Gly Thr Gly Asn Phe Lys Lys Arg Lys Phe 
                85                  90                  95      
Asp Thr Glu Thr Lys Asp Cys Asn Glu Lys Lys Lys Lys Met Thr Met 
            100                 105                 110         
Asn Arg Asp Asp Leu Val Glu Glu Gly Glu Glu Glu Lys Ser Lys Ile 
        115                 120                 125             
Thr Glu Gln Asn Asn Gly Ser Thr Lys Ser Ile Lys Lys Met Lys His 
    130                 135                 140                 
Lys Ala Lys Lys Glu Glu Asn Asn Phe Ser Asn Asp Ser Ser Lys Val 
145                 150                 155                 160 
Thr Lys Glu Leu Glu Lys Thr Asp Tyr Ile His Gly Gly Gly Gly Ser 
                165                 170                 175     
Gly Gly Gly Gly Ser Gly Gly Gly Gly Arg Arg Pro Ser Asp Ser Asn 
            180                 185                 190         
Ala Val Ser Leu Val Met Arg Arg Ile Arg Lys Glu Asn Val Asp Ala 
        195                 200                 205             
Gly Glu Arg Ala Lys Gln Ala Leu Ala Phe Glu Arg Thr Asp Phe Asp 
    210                 215                 220                 
Gln Val Arg Ser Leu Met Glu Asn Ser Asp Arg Cys Gln Asp Ile Arg 
225                 230                 235                 240 
Asn Leu Ala Phe Leu Gly Ile Ala Tyr Asn Thr Leu Leu Arg Ile Ala 
                245                 250                 255     
Glu Ile Ala Arg Ile Arg Val Lys Asp Ile Ser Arg Thr Asp Gly Gly 
            260                 265                 270         
Arg Met Leu Ile His Ile Gly Arg Thr Lys Thr Leu Val Ser Thr Ala 
        275                 280                 285             
Gly Val Glu Lys Ala Leu Ser Leu Gly Val Thr Lys Leu Val Glu Arg 
    290                 295                 300                 
Trp Ile Ser Val Ser Gly Val Ala Asp Asp Pro Asn Asn Tyr Leu Phe 
305                 310                 315                 320 
Cys Arg Val Arg Lys Asn Gly Val Ala Ala Pro Ser Ala Thr Ser Gln 
                325                 330                 335     
Leu Ser Thr Arg Ala Leu Glu Gly Ile Phe Glu Ala Thr His Arg Leu 
            340                 345                 350         
Ile Tyr Gly Ala Lys Asp Asp Ser Gly Gln Arg Tyr Leu Ala Trp Ser 
        355                 360                 365             
Gly His Ser Ala Arg Val Gly Ala Ala Arg Asp Met Ala Arg Ala Gly 
    370                 375                 380                 
Val Ser Ile Pro Glu Ile Met Gln Ala Gly Gly Trp Thr Asn Val Asn 
385                 390                 395                 400 
Ile Val Met Asn Tyr Ile Arg Asn Leu Asp Ser Glu Thr Gly Ala Met 
                405                 410                 415     
Val Arg Leu Leu Glu Asp Gly Asp 
            420                 

<210> 5
<211> 2142
<212> DNA
<213> Artificial Sequence


<220> 
<223> fusion protein of CRY2 and CreN

<220> 
<221> CDS
<222> 1..2142
<223> /product="fusion protein of CRY2 and CreN "
      /transl_table=1

<400> 5
atg aag atg gac aaa aag act ata gtt tgg ttt aga aga gac cta agg      48
Met Lys Met Asp Lys Lys Thr Ile Val Trp Phe Arg Arg Asp Leu Arg 
1               5                   10                  15      

att gag gat aat cct gca tta gca gca gct gct cac gaa gga tct gtt      96
Ile Glu Asp Asn Pro Ala Leu Ala Ala Ala Ala His Glu Gly Ser Val 
            20                  25                  30          

ttt cct gtc ttc att tgg tgt cct gaa gaa gaa gga cag ttt tat cct     144
Phe Pro Val Phe Ile Trp Cys Pro Glu Glu Glu Gly Gln Phe Tyr Pro 
        35                  40                  45              

gga aga gct tca aga tgg tgg atg aaa caa tca ctt gct cac tta tct     192
Gly Arg Ala Ser Arg Trp Trp Met Lys Gln Ser Leu Ala His Leu Ser 
    50                  55                  60                  

caa tcc ttg aag gct ctt gga tct gac ctc act tta atc aaa acc cac     240
Gln Ser Leu Lys Ala Leu Gly Ser Asp Leu Thr Leu Ile Lys Thr His 
65                  70                  75                  80  

aac acg att tca gcg atc ttg gat tgt atc cgc gtt acc ggt gct aca     288
Asn Thr Ile Ser Ala Ile Leu Asp Cys Ile Arg Val Thr Gly Ala Thr 
                85                  90                  95      

aaa gtc gtc ttt aac cac ctc tat gat cct gtt tcg tta gtt cgg gac     336
Lys Val Val Phe Asn His Leu Tyr Asp Pro Val Ser Leu Val Arg Asp 
            100                 105                 110         

cat acc gta aag gag aag ctg gtg gaa cgt ggg atc tct gtg caa agc     384
His Thr Val Lys Glu Lys Leu Val Glu Arg Gly Ile Ser Val Gln Ser 
        115                 120                 125             

tac aat gga gat cta ttg tat gaa ccg tgg gag ata tac tgc gaa aag     432
Tyr Asn Gly Asp Leu Leu Tyr Glu Pro Trp Glu Ile Tyr Cys Glu Lys 
    130                 135                 140                 

ggc aaa cct ttt acg agt ttc aat tct tac tgg aag aaa tgc tta gat     480
Gly Lys Pro Phe Thr Ser Phe Asn Ser Tyr Trp Lys Lys Cys Leu Asp 
145                 150                 155                 160 

atg tcg att gaa tcc gtt atg ctt cct cct cct tgg cgg ttg atg cca     528
Met Ser Ile Glu Ser Val Met Leu Pro Pro Pro Trp Arg Leu Met Pro 
                165                 170                 175     

ata act gca gcg gct gaa gcg att tgg gcg tgt tcg att gaa gaa cta     576
Ile Thr Ala Ala Ala Glu Ala Ile Trp Ala Cys Ser Ile Glu Glu Leu 
            180                 185                 190         

ggg ctg gag aat gag gcc gag aaa ccg agc aat gcg ttg tta act aga     624
Gly Leu Glu Asn Glu Ala Glu Lys Pro Ser Asn Ala Leu Leu Thr Arg 
        195                 200                 205             

gct tgg tct cca gga tgg agc aat gct gat aag tta cta aat gag ttc     672
Ala Trp Ser Pro Gly Trp Ser Asn Ala Asp Lys Leu Leu Asn Glu Phe 
    210                 215                 220                 

atc gag aag cag ttg ata gat tat gca aag aac agc aag aaa gtt gtt     720
Ile Glu Lys Gln Leu Ile Asp Tyr Ala Lys Asn Ser Lys Lys Val Val 
225                 230                 235                 240 

ggg aat tct act tca cta ctt tct ccg tat ctc cat ttc ggg gaa ata     768
Gly Asn Ser Thr Ser Leu Leu Ser Pro Tyr Leu His Phe Gly Glu Ile 
                245                 250                 255     

agc gtc aga cac gtt ttc cag tgt gcc cgg atg aaa caa att ata tgg     816
Ser Val Arg His Val Phe Gln Cys Ala Arg Met Lys Gln Ile Ile Trp 
            260                 265                 270         

gca aga gat aag aac agt gaa gga gaa gaa agt gca gat ctt ttt ctt     864
Ala Arg Asp Lys Asn Ser Glu Gly Glu Glu Ser Ala Asp Leu Phe Leu 
        275                 280                 285             

agg gga atc ggt tta aga gag tat tct cgg tat ata tgt ttc aac ttc     912
Arg Gly Ile Gly Leu Arg Glu Tyr Ser Arg Tyr Ile Cys Phe Asn Phe 
    290                 295                 300                 

ccg ttt act cac gag caa tcg ttg ttg agt cat ctt cgg ttt ttc cct     960
Pro Phe Thr His Glu Gln Ser Leu Leu Ser His Leu Arg Phe Phe Pro 
305                 310                 315                 320 

tgg gat gct gat gtt gat aag ttc aag gcc tgg aga caa ggc agg acc    1008
Trp Asp Ala Asp Val Asp Lys Phe Lys Ala Trp Arg Gln Gly Arg Thr 
                325                 330                 335     

ggt tat ccg ttg gtg gat gcc gga atg aga gag ctt tgg gct acc gga    1056
Gly Tyr Pro Leu Val Asp Ala Gly Met Arg Glu Leu Trp Ala Thr Gly 
            340                 345                 350         

tgg atg cat aac aga ata aga gtg att gtt tca agc ttt gct gtg aag    1104
Trp Met His Asn Arg Ile Arg Val Ile Val Ser Ser Phe Ala Val Lys 
        355                 360                 365             

ttt ctt ctc ctt cca tgg aaa tgg gga atg aag tat ttc tgg gat aca    1152
Phe Leu Leu Leu Pro Trp Lys Trp Gly Met Lys Tyr Phe Trp Asp Thr 
    370                 375                 380                 

ctt ttg gat gct gat ttg gaa tgt gac atc ctt ggc tgg cag tat atc    1200
Leu Leu Asp Ala Asp Leu Glu Cys Asp Ile Leu Gly Trp Gln Tyr Ile 
385                 390                 395                 400 

tct ggg agt atc ccc gat ggc cac gag ctt gat cgc ttg gac aat ccc    1248
Ser Gly Ser Ile Pro Asp Gly His Glu Leu Asp Arg Leu Asp Asn Pro 
                405                 410                 415     

gcg tta caa ggc gcc aaa tat gac cca gaa ggt gag tac ata agg caa    1296
Ala Leu Gln Gly Ala Lys Tyr Asp Pro Glu Gly Glu Tyr Ile Arg Gln 
            420                 425                 430         

tgg ctt ccc gag ctt gcg aga ttg cca act gaa tgg atc cat cat cca    1344
Trp Leu Pro Glu Leu Ala Arg Leu Pro Thr Glu Trp Ile His His Pro 
        435                 440                 445             

tgg gac gct cct tta acc gta ctc aaa gct tct ggt gtg gaa ctc gga    1392
Trp Asp Ala Pro Leu Thr Val Leu Lys Ala Ser Gly Val Glu Leu Gly 
    450                 455                 460                 

aca aac tat gcg aaa ccc att gta gac atc gac aca gct cgt gag cta    1440
Thr Asn Tyr Ala Lys Pro Ile Val Asp Ile Asp Thr Ala Arg Glu Leu 
465                 470                 475                 480 

cta gct aaa gct att tca aga acc cgt gaa gca cag atc atg atc gga    1488
Leu Ala Lys Ala Ile Ser Arg Thr Arg Glu Ala Gln Ile Met Ile Gly 
                485                 490                 495     

gca gca cct gat gag att gta gca gat agc ttc gag gcc tta ggg gct    1536
Ala Ala Pro Asp Glu Ile Val Ala Asp Ser Phe Glu Ala Leu Gly Ala 
            500                 505                 510         

aat acc att aaa gaa cct ggt ctt tgc cca tct gtg tct tct aat gac    1584
Asn Thr Ile Lys Glu Pro Gly Leu Cys Pro Ser Val Ser Ser Asn Asp 
        515                 520                 525             

caa caa gta cct tcg gct gtt cgt tac aac ggg tca aag aga gtg aaa    1632
Gln Gln Val Pro Ser Ala Val Arg Tyr Asn Gly Ser Lys Arg Val Lys 
    530                 535                 540                 

cct gag gaa gaa gaa gag aga gac atg aag aaa tct agg gga ttc gat    1680
Pro Glu Glu Glu Glu Glu Arg Asp Met Lys Lys Ser Arg Gly Phe Asp 
545                 550                 555                 560 

gaa agg gag ttg ttt tcg act gct gaa tct tct tct tct tcg agt gtg    1728
Glu Arg Glu Leu Phe Ser Thr Ala Glu Ser Ser Ser Ser Ser Ser Val 
                565                 570                 575     

ttt ttc gtt tcg cag tct tgc tcg ttg gca tca gaa ggg aag aat ctg    1776
Phe Phe Val Ser Gln Ser Cys Ser Leu Ala Ser Glu Gly Lys Asn Leu 
            580                 585                 590         

gaa ggt att caa gat tca tct gat cag att act aca agt ttg gga aaa    1824
Glu Gly Ile Gln Asp Ser Ser Asp Gln Ile Thr Thr Ser Leu Gly Lys 
        595                 600                 605             

aat ggt tgc aaa ggt ggc ggt ggc tct gga ggt ggt ggg tcc gga gga    1872
Asn Gly Cys Lys Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
    610                 615                 620                 

ggc ggc cgc acg agt gat gag gtt cgc aag aac ctg atg gac atg ttc    1920
Gly Gly Arg Thr Ser Asp Glu Val Arg Lys Asn Leu Met Asp Met Phe 
625                 630                 635                 640 

agg gat cgc cag gcg ttt tct gag cat acc tgg aaa atg ctt ctg tcc    1968
Arg Asp Arg Gln Ala Phe Ser Glu His Thr Trp Lys Met Leu Leu Ser 
                645                 650                 655     

gtt tgc cgg tcg tgg gcg gca tgg tgc aag ttg aat aac cgg aaa tgg    2016
Val Cys Arg Ser Trp Ala Ala Trp Cys Lys Leu Asn Asn Arg Lys Trp 
            660                 665                 670         

ttt ccc gca gaa cct gaa gat gtt cgc gat tat ctt cta tat ctt cag    2064
Phe Pro Ala Glu Pro Glu Asp Val Arg Asp Tyr Leu Leu Tyr Leu Gln 
        675                 680                 685             

gcg cgc ggt ctg gca gta aaa act atc cag caa cat ttg ggc cag cta    2112
Ala Arg Gly Leu Ala Val Lys Thr Ile Gln Gln His Leu Gly Gln Leu 
    690                 695                 700                 

aac atg ctt cat cgt cgg tcc ggg ctg taa                            2142
Asn Met Leu His Arg Arg Ser Gly Leu     
705                 710                 

<210> 6
<211> 713
<212> PRT
<213> Artificial Sequence


<220> 
<223> [CDS]:1..2142 from SEQ ID NO 5

<400> 6
Met Lys Met Asp Lys Lys Thr Ile Val Trp Phe Arg Arg Asp Leu Arg 
1               5                   10                  15      
Ile Glu Asp Asn Pro Ala Leu Ala Ala Ala Ala His Glu Gly Ser Val 
            20                  25                  30          
Phe Pro Val Phe Ile Trp Cys Pro Glu Glu Glu Gly Gln Phe Tyr Pro 
        35                  40                  45              
Gly Arg Ala Ser Arg Trp Trp Met Lys Gln Ser Leu Ala His Leu Ser 
    50                  55                  60                  
Gln Ser Leu Lys Ala Leu Gly Ser Asp Leu Thr Leu Ile Lys Thr His 
65                  70                  75                  80  
Asn Thr Ile Ser Ala Ile Leu Asp Cys Ile Arg Val Thr Gly Ala Thr 
                85                  90                  95      
Lys Val Val Phe Asn His Leu Tyr Asp Pro Val Ser Leu Val Arg Asp 
            100                 105                 110         
His Thr Val Lys Glu Lys Leu Val Glu Arg Gly Ile Ser Val Gln Ser 
        115                 120                 125             
Tyr Asn Gly Asp Leu Leu Tyr Glu Pro Trp Glu Ile Tyr Cys Glu Lys 
    130                 135                 140                 
Gly Lys Pro Phe Thr Ser Phe Asn Ser Tyr Trp Lys Lys Cys Leu Asp 
145                 150                 155                 160 
Met Ser Ile Glu Ser Val Met Leu Pro Pro Pro Trp Arg Leu Met Pro 
                165                 170                 175     
Ile Thr Ala Ala Ala Glu Ala Ile Trp Ala Cys Ser Ile Glu Glu Leu 
            180                 185                 190         
Gly Leu Glu Asn Glu Ala Glu Lys Pro Ser Asn Ala Leu Leu Thr Arg 
        195                 200                 205             
Ala Trp Ser Pro Gly Trp Ser Asn Ala Asp Lys Leu Leu Asn Glu Phe 
    210                 215                 220                 
Ile Glu Lys Gln Leu Ile Asp Tyr Ala Lys Asn Ser Lys Lys Val Val 
225                 230                 235                 240 
Gly Asn Ser Thr Ser Leu Leu Ser Pro Tyr Leu His Phe Gly Glu Ile 
                245                 250                 255     
Ser Val Arg His Val Phe Gln Cys Ala Arg Met Lys Gln Ile Ile Trp 
            260                 265                 270         
Ala Arg Asp Lys Asn Ser Glu Gly Glu Glu Ser Ala Asp Leu Phe Leu 
        275                 280                 285             
Arg Gly Ile Gly Leu Arg Glu Tyr Ser Arg Tyr Ile Cys Phe Asn Phe 
    290                 295                 300                 
Pro Phe Thr His Glu Gln Ser Leu Leu Ser His Leu Arg Phe Phe Pro 
305                 310                 315                 320 
Trp Asp Ala Asp Val Asp Lys Phe Lys Ala Trp Arg Gln Gly Arg Thr 
                325                 330                 335     
Gly Tyr Pro Leu Val Asp Ala Gly Met Arg Glu Leu Trp Ala Thr Gly 
            340                 345                 350         
Trp Met His Asn Arg Ile Arg Val Ile Val Ser Ser Phe Ala Val Lys 
        355                 360                 365             
Phe Leu Leu Leu Pro Trp Lys Trp Gly Met Lys Tyr Phe Trp Asp Thr 
    370                 375                 380                 
Leu Leu Asp Ala Asp Leu Glu Cys Asp Ile Leu Gly Trp Gln Tyr Ile 
385                 390                 395                 400 
Ser Gly Ser Ile Pro Asp Gly His Glu Leu Asp Arg Leu Asp Asn Pro 
                405                 410                 415     
Ala Leu Gln Gly Ala Lys Tyr Asp Pro Glu Gly Glu Tyr Ile Arg Gln 
            420                 425                 430         
Trp Leu Pro Glu Leu Ala Arg Leu Pro Thr Glu Trp Ile His His Pro 
        435                 440                 445             
Trp Asp Ala Pro Leu Thr Val Leu Lys Ala Ser Gly Val Glu Leu Gly 
    450                 455                 460                 
Thr Asn Tyr Ala Lys Pro Ile Val Asp Ile Asp Thr Ala Arg Glu Leu 
465                 470                 475                 480 
Leu Ala Lys Ala Ile Ser Arg Thr Arg Glu Ala Gln Ile Met Ile Gly 
                485                 490                 495     
Ala Ala Pro Asp Glu Ile Val Ala Asp Ser Phe Glu Ala Leu Gly Ala 
            500                 505                 510         
Asn Thr Ile Lys Glu Pro Gly Leu Cys Pro Ser Val Ser Ser Asn Asp 
        515                 520                 525             
Gln Gln Val Pro Ser Ala Val Arg Tyr Asn Gly Ser Lys Arg Val Lys 
    530                 535                 540                 
Pro Glu Glu Glu Glu Glu Arg Asp Met Lys Lys Ser Arg Gly Phe Asp 
545                 550                 555                 560 
Glu Arg Glu Leu Phe Ser Thr Ala Glu Ser Ser Ser Ser Ser Ser Val 
                565                 570                 575     
Phe Phe Val Ser Gln Ser Cys Ser Leu Ala Ser Glu Gly Lys Asn Leu 
            580                 585                 590         
Glu Gly Ile Gln Asp Ser Ser Asp Gln Ile Thr Thr Ser Leu Gly Lys 
        595                 600                 605             
Asn Gly Cys Lys Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
    610                 615                 620                 
Gly Gly Arg Thr Ser Asp Glu Val Arg Lys Asn Leu Met Asp Met Phe 
625                 630                 635                 640 
Arg Asp Arg Gln Ala Phe Ser Glu His Thr Trp Lys Met Leu Leu Ser 
                645                 650                 655     
Val Cys Arg Ser Trp Ala Ala Trp Cys Lys Leu Asn Asn Arg Lys Trp 
            660                 665                 670         
Phe Pro Ala Glu Pro Glu Asp Val Arg Asp Tyr Leu Leu Tyr Leu Gln 
        675                 680                 685             
Ala Arg Gly Leu Ala Val Lys Thr Ile Gln Gln His Leu Gly Gln Leu 
    690                 695                 700                 
Asn Met Leu His Arg Arg Ser Gly Leu 
705                 710             

