               SEQUENCE LISTING

<110> Merz Pharma GmbH & Co. KGaA

<120> Pain therapy with botulinum toxin in lipoedema                                                      

<130> 2717-000-PCT

<150> EP18198238.0 
<151> 2018-10-02

<160> 14

<170> BiSSAP 1.3.5

<210> 1
<211> 3891
<212> DNA
<213> Clostridium botulinum


<400> 1
atgccatttg ttaataaaca atttaattat aaagatcctg taaatggtgt tgatattgct       60

tatataaaaa ttccaaatgc aggacaaatg caaccagtaa aagcttttaa aattcataat      120

aaaatatggg ttattccaga aagagataca tttacaaatc ctgaagaagg agatttaaat      180

ccaccaccag aagcaaaaca agttccagtt tcatattatg attcaacata tttaagtaca      240

gataatgaaa aagataatta tttaaaggga gttacaaaat tatttgagag aatttattca      300

actgatcttg gaagaatgtt gttaacatca atagtaaggg gaataccatt ttggggtgga      360

agtacaatag atacagaatt aaaagttatt gatactaatt gtattaatgt gatacaacca      420

gatggtagtt atagatcaga agaacttaat ctagtaataa taggaccctc agctgatatt      480

atacagtttg aatgtaaaag ctttggacat gaagttttga atcttacgcg aaatggttat      540

ggctctactc aatacattag atttagccca gattttacat ttggttttga ggagtcactt      600

gaagttgata caaatcctct tttaggtgca ggcaaatttg ctacagatcc agcagtaaca      660

ttagcacatg aacttataca tgctggacat agattatatg gaatagcaat taatccaaat      720

agggttttta aagtaaatac taatgcctat tatgaaatga gtgggttaga agtaagcttt      780

gaggaactta gaacatttgg gggacatgat gcaaagttta tagatagttt acaggaaaac      840

gaatttcgtc tatattatta taataagttt aaagatatag caagtacact taataaagct      900

aaatcaatag taggtactac tgcttcatta cagtatatga aaaatgtttt taaagagaaa      960

tatctcctat ctgaagatac atctggaaaa ttttcggtag ataaattaaa atttgataag     1020

ttatacaaaa tgttaacaga gatttacaca gaggataatt ttgttaagtt ttttaaagta     1080

cttaacagaa aaacatattt gaattttgat aaagccgtat ttaagataaa tatagtacct     1140

aaggtaaatt acacaatata tgatggattt aatttaagaa atacaaattt agcagcaaac     1200

tttaatggtc aaaatacaga aattaataat atgaatttta ctaaactaaa aaattttact     1260

ggattgtttg aattttataa gttgctatgt gtaagaggga taataacttc taaaactaaa     1320

tcattagata aaggatacaa taaggcatta aatgatttat gtatcaaagt taataattgg     1380

gacttgtttt ttagtccttc agaagataat tttactaatg atctaaataa aggagaagaa     1440

attacatctg atactaatat agaagcagca gaagaaaata ttagtttaga tttaatacaa     1500

caatattatt taacctttaa ttttgataat gaacctgaaa atatttcaat agaaaatctt     1560

tcaagtgaca ttataggcca attagaactt atgcctaata tagaaagatt tcctaatgga     1620

aaaaagtatg agttagataa atatactatg ttccattatc ttcgtgctca agaatttgaa     1680

catggtaaat ctaggattgc tttaacaaat tctgttaacg aagcattatt aaatcctagt     1740

cgtgtttata catttttttc ttcagactat gtaaagaaag ttaataaagc tacggaggca     1800

gctatgtttt taggctgggt agaacaatta gtatatgatt ttaccgatga aactagcgaa     1860

gtaagtacta cggataaaat tgcggatata actataatta ttccatatat aggacctgct     1920

ttaaatatag gtaatatgtt atataaagat gattttgtag gtgctttaat attttcagga     1980

gctgttattc tgttagaatt tataccagag attgcaatac ctgtattagg tacttttgca     2040

cttgtatcat atattgcgaa taaggttcta accgttcaaa caatagataa tgctttaagt     2100

aaaagaaatg aaaaatggga tgaggtctat aaatatatag taacaaattg gttagcaaag     2160

gttaatacac agattgatct aataagaaaa aaaatgaaag aagctttaga aaatcaagca     2220

gaagcaacaa aggctataat aaactatcag tataatcaat atactgagga agagaaaaat     2280

aatattaatt ttaatattga tgatttaagt tcgaaactta atgagtctat aaataaagct     2340

atgattaata taaataaatt tttgaatcaa tgctctgttt catatttaat gaattctatg     2400

atcccttatg gtgttaaacg gttagaagat tttgatgcta gtcttaaaga tgcattatta     2460

aagtatatat atgataatag aggaacttta attggtcaag tagatagatt aaaagataaa     2520

gttaataata cacttagtac agatatacct tttcagcttt ccaaatacgt agataatcaa     2580

agattattat ctacatttac tgaatatatt aagaatatta ttaatacttc tatattgaat     2640

ttaagatatg aaagtaatca tttaatagac ttatctaggt atgcatcaaa aataaatatt     2700

ggtagtaaag taaattttga tccaatagat aaaaatcaaa ttcaattatt taatttagaa     2760

agtagtaaaa ttgaggtaat tttaaaaaat gctattgtat ataatagtat gtatgaaaat     2820

tttagtacta gcttttggat aagaattcct aagtatttta acagtataag tctaaataat     2880

gaatatacaa taataaattg tatggaaaat aattcaggat ggaaagtatc acttaattat     2940

ggtgaaataa tctggacttt acaggatact caggaaataa aacaaagagt agtttttaaa     3000

tacagtcaaa tgattaatat atcagattat ataaacagat ggatttttgt aactatcact     3060

aataatagat taaataactc taaaatttat ataaatggaa gattaataga tcaaaaacca     3120

atttcaaatt taggtaatat tcatgctagt aataatataa tgtttaaatt agatggttgt     3180

agagatacac atagatatat ttggataaaa tattttaatc tttttgataa ggaattaaat     3240

gaaaaagaaa tcaaagattt atatgataat caatcaaatt caggtatttt aaaagacttt     3300

tggggtgatt atttacaata tgataaacca tactatatgt taaatttata tgatccaaat     3360

aaatatgtcg atgtaaataa tgtaggtatt agaggttata tgtatcttaa agggcctaga     3420

ggtagcgtaa tgactacaaa catttattta aattcaagtt tgtatagggg gacaaaattt     3480

attataaaaa aatatgcttc tggaaataaa gataatattg ttagaaataa tgatcgtgta     3540

tatattaatg tagtagttaa aaataaagaa tataggttag ctactaatgc atcacaggca     3600

ggcgtagaaa aaatactaag tgcattagaa atacctgatg taggaaatct aagtcaagta     3660

gtagtaatga agtcaaaaaa tgatcaagga ataacaaata aatgcaaaat gaatttacaa     3720

gataataatg ggaatgatat aggctttata ggatttcatc agtttaataa tatagctaaa     3780

ctagtagcaa gtaattggta taatagacaa atagaaagat ctagtaggac tttgggttgc     3840

tcatgggaat ttattcctgt agatgatgga tggggagaaa ggccactgta a              3891


<210> 2
<211> 1296
<212> PRT
<213> Clostridium botulinum


<400> 2
Met Pro Phe Val Asn Lys Gln Phe Asn Tyr Lys Asp Pro Val Asn Gly 
1               5                   10                  15      
Val Asp Ile Ala Tyr Ile Lys Ile Pro Asn Ala Gly Gln Met Gln Pro 
            20                  25                  30          
Val Lys Ala Phe Lys Ile His Asn Lys Ile Trp Val Ile Pro Glu Arg 
        35                  40                  45              
Asp Thr Phe Thr Asn Pro Glu Glu Gly Asp Leu Asn Pro Pro Pro Glu 
    50                  55                  60                  
Ala Lys Gln Val Pro Val Ser Tyr Tyr Asp Ser Thr Tyr Leu Ser Thr 
65                  70                  75                  80  
Asp Asn Glu Lys Asp Asn Tyr Leu Lys Gly Val Thr Lys Leu Phe Glu 
                85                  90                  95      
Arg Ile Tyr Ser Thr Asp Leu Gly Arg Met Leu Leu Thr Ser Ile Val 
            100                 105                 110         
Arg Gly Ile Pro Phe Trp Gly Gly Ser Thr Ile Asp Thr Glu Leu Lys 
        115                 120                 125             
Val Ile Asp Thr Asn Cys Ile Asn Val Ile Gln Pro Asp Gly Ser Tyr 
    130                 135                 140                 
Arg Ser Glu Glu Leu Asn Leu Val Ile Ile Gly Pro Ser Ala Asp Ile 
145                 150                 155                 160 
Ile Gln Phe Glu Cys Lys Ser Phe Gly His Glu Val Leu Asn Leu Thr 
                165                 170                 175     
Arg Asn Gly Tyr Gly Ser Thr Gln Tyr Ile Arg Phe Ser Pro Asp Phe 
            180                 185                 190         
Thr Phe Gly Phe Glu Glu Ser Leu Glu Val Asp Thr Asn Pro Leu Leu 
        195                 200                 205             
Gly Ala Gly Lys Phe Ala Thr Asp Pro Ala Val Thr Leu Ala His Glu 
    210                 215                 220                 
Leu Ile His Ala Gly His Arg Leu Tyr Gly Ile Ala Ile Asn Pro Asn 
225                 230                 235                 240 
Arg Val Phe Lys Val Asn Thr Asn Ala Tyr Tyr Glu Met Ser Gly Leu 
                245                 250                 255     
Glu Val Ser Phe Glu Glu Leu Arg Thr Phe Gly Gly His Asp Ala Lys 
            260                 265                 270         
Phe Ile Asp Ser Leu Gln Glu Asn Glu Phe Arg Leu Tyr Tyr Tyr Asn 
        275                 280                 285             
Lys Phe Lys Asp Ile Ala Ser Thr Leu Asn Lys Ala Lys Ser Ile Val 
    290                 295                 300                 
Gly Thr Thr Ala Ser Leu Gln Tyr Met Lys Asn Val Phe Lys Glu Lys 
305                 310                 315                 320 
Tyr Leu Leu Ser Glu Asp Thr Ser Gly Lys Phe Ser Val Asp Lys Leu 
                325                 330                 335     
Lys Phe Asp Lys Leu Tyr Lys Met Leu Thr Glu Ile Tyr Thr Glu Asp 
            340                 345                 350         
Asn Phe Val Lys Phe Phe Lys Val Leu Asn Arg Lys Thr Tyr Leu Asn 
        355                 360                 365             
Phe Asp Lys Ala Val Phe Lys Ile Asn Ile Val Pro Lys Val Asn Tyr 
    370                 375                 380                 
Thr Ile Tyr Asp Gly Phe Asn Leu Arg Asn Thr Asn Leu Ala Ala Asn 
385                 390                 395                 400 
Phe Asn Gly Gln Asn Thr Glu Ile Asn Asn Met Asn Phe Thr Lys Leu 
                405                 410                 415     
Lys Asn Phe Thr Gly Leu Phe Glu Phe Tyr Lys Leu Leu Cys Val Arg 
            420                 425                 430         
Gly Ile Ile Thr Ser Lys Thr Lys Ser Leu Asp Lys Gly Tyr Asn Lys 
        435                 440                 445             
Ala Leu Asn Asp Leu Cys Ile Lys Val Asn Asn Trp Asp Leu Phe Phe 
    450                 455                 460                 
Ser Pro Ser Glu Asp Asn Phe Thr Asn Asp Leu Asn Lys Gly Glu Glu 
465                 470                 475                 480 
Ile Thr Ser Asp Thr Asn Ile Glu Ala Ala Glu Glu Asn Ile Ser Leu 
                485                 490                 495     
Asp Leu Ile Gln Gln Tyr Tyr Leu Thr Phe Asn Phe Asp Asn Glu Pro 
            500                 505                 510         
Glu Asn Ile Ser Ile Glu Asn Leu Ser Ser Asp Ile Ile Gly Gln Leu 
        515                 520                 525             
Glu Leu Met Pro Asn Ile Glu Arg Phe Pro Asn Gly Lys Lys Tyr Glu 
    530                 535                 540                 
Leu Asp Lys Tyr Thr Met Phe His Tyr Leu Arg Ala Gln Glu Phe Glu 
545                 550                 555                 560 
His Gly Lys Ser Arg Ile Ala Leu Thr Asn Ser Val Asn Glu Ala Leu 
                565                 570                 575     
Leu Asn Pro Ser Arg Val Tyr Thr Phe Phe Ser Ser Asp Tyr Val Lys 
            580                 585                 590         
Lys Val Asn Lys Ala Thr Glu Ala Ala Met Phe Leu Gly Trp Val Glu 
        595                 600                 605             
Gln Leu Val Tyr Asp Phe Thr Asp Glu Thr Ser Glu Val Ser Thr Thr 
    610                 615                 620                 
Asp Lys Ile Ala Asp Ile Thr Ile Ile Ile Pro Tyr Ile Gly Pro Ala 
625                 630                 635                 640 
Leu Asn Ile Gly Asn Met Leu Tyr Lys Asp Asp Phe Val Gly Ala Leu 
                645                 650                 655     
Ile Phe Ser Gly Ala Val Ile Leu Leu Glu Phe Ile Pro Glu Ile Ala 
            660                 665                 670         
Ile Pro Val Leu Gly Thr Phe Ala Leu Val Ser Tyr Ile Ala Asn Lys 
        675                 680                 685             
Val Leu Thr Val Gln Thr Ile Asp Asn Ala Leu Ser Lys Arg Asn Glu 
    690                 695                 700                 
Lys Trp Asp Glu Val Tyr Lys Tyr Ile Val Thr Asn Trp Leu Ala Lys 
705                 710                 715                 720 
Val Asn Thr Gln Ile Asp Leu Ile Arg Lys Lys Met Lys Glu Ala Leu 
                725                 730                 735     
Glu Asn Gln Ala Glu Ala Thr Lys Ala Ile Ile Asn Tyr Gln Tyr Asn 
            740                 745                 750         
Gln Tyr Thr Glu Glu Glu Lys Asn Asn Ile Asn Phe Asn Ile Asp Asp 
        755                 760                 765             
Leu Ser Ser Lys Leu Asn Glu Ser Ile Asn Lys Ala Met Ile Asn Ile 
    770                 775                 780                 
Asn Lys Phe Leu Asn Gln Cys Ser Val Ser Tyr Leu Met Asn Ser Met 
785                 790                 795                 800 
Ile Pro Tyr Gly Val Lys Arg Leu Glu Asp Phe Asp Ala Ser Leu Lys 
                805                 810                 815     
Asp Ala Leu Leu Lys Tyr Ile Tyr Asp Asn Arg Gly Thr Leu Ile Gly 
            820                 825                 830         
Gln Val Asp Arg Leu Lys Asp Lys Val Asn Asn Thr Leu Ser Thr Asp 
        835                 840                 845             
Ile Pro Phe Gln Leu Ser Lys Tyr Val Asp Asn Gln Arg Leu Leu Ser 
    850                 855                 860                 
Thr Phe Thr Glu Tyr Ile Lys Asn Ile Ile Asn Thr Ser Ile Leu Asn 
865                 870                 875                 880 
Leu Arg Tyr Glu Ser Asn His Leu Ile Asp Leu Ser Arg Tyr Ala Ser 
                885                 890                 895     
Lys Ile Asn Ile Gly Ser Lys Val Asn Phe Asp Pro Ile Asp Lys Asn 
            900                 905                 910         
Gln Ile Gln Leu Phe Asn Leu Glu Ser Ser Lys Ile Glu Val Ile Leu 
        915                 920                 925             
Lys Asn Ala Ile Val Tyr Asn Ser Met Tyr Glu Asn Phe Ser Thr Ser 
    930                 935                 940                 
Phe Trp Ile Arg Ile Pro Lys Tyr Phe Asn Ser Ile Ser Leu Asn Asn 
945                 950                 955                 960 
Glu Tyr Thr Ile Ile Asn Cys Met Glu Asn Asn Ser Gly Trp Lys Val 
                965                 970                 975     
Ser Leu Asn Tyr Gly Glu Ile Ile Trp Thr Leu Gln Asp Thr Gln Glu 
            980                 985                 990         
Ile Lys Gln Arg Val Val Phe Lys Tyr Ser Gln Met Ile Asn Ile Ser 
        995                 1000                1005            
Asp Tyr Ile Asn Arg Trp Ile Phe Val Thr Ile Thr Asn Asn Arg Leu 
    1010                1015                1020                
Asn Asn Ser Lys Ile Tyr Ile Asn Gly Arg Leu Ile Asp Gln Lys Pro 
1025                1030                1035                1040
Ile Ser Asn Leu Gly Asn Ile His Ala Ser Asn Asn Ile Met Phe Lys 
                1045                1050                1055    
Leu Asp Gly Cys Arg Asp Thr His Arg Tyr Ile Trp Ile Lys Tyr Phe 
            1060                1065                1070        
Asn Leu Phe Asp Lys Glu Leu Asn Glu Lys Glu Ile Lys Asp Leu Tyr 
        1075                1080                1085            
Asp Asn Gln Ser Asn Ser Gly Ile Leu Lys Asp Phe Trp Gly Asp Tyr 
    1090                1095                1100                
Leu Gln Tyr Asp Lys Pro Tyr Tyr Met Leu Asn Leu Tyr Asp Pro Asn 
1105                1110                1115                1120
Lys Tyr Val Asp Val Asn Asn Val Gly Ile Arg Gly Tyr Met Tyr Leu 
                1125                1130                1135    
Lys Gly Pro Arg Gly Ser Val Met Thr Thr Asn Ile Tyr Leu Asn Ser 
            1140                1145                1150        
Ser Leu Tyr Arg Gly Thr Lys Phe Ile Ile Lys Lys Tyr Ala Ser Gly 
        1155                1160                1165            
Asn Lys Asp Asn Ile Val Arg Asn Asn Asp Arg Val Tyr Ile Asn Val 
    1170                1175                1180                
Val Val Lys Asn Lys Glu Tyr Arg Leu Ala Thr Asn Ala Ser Gln Ala 
1185                1190                1195                1200
Gly Val Glu Lys Ile Leu Ser Ala Leu Glu Ile Pro Asp Val Gly Asn 
                1205                1210                1215    
Leu Ser Gln Val Val Val Met Lys Ser Lys Asn Asp Gln Gly Ile Thr 
            1220                1225                1230        
Asn Lys Cys Lys Met Asn Leu Gln Asp Asn Asn Gly Asn Asp Ile Gly 
        1235                1240                1245            
Phe Ile Gly Phe His Gln Phe Asn Asn Ile Ala Lys Leu Val Ala Ser 
    1250                1255                1260                
Asn Trp Tyr Asn Arg Gln Ile Glu Arg Ser Ser Arg Thr Leu Gly Cys 
1265                1270                1275                1280
Ser Trp Glu Phe Ile Pro Val Asp Asp Gly Trp Gly Glu Arg Pro Leu 
                1285                1290                1295    



<210> 3
<211> 3876
<212> DNA
<213> Clostridium botulinum


<400> 3
atgccagtta caataaataa ttttaattat aatgatccta ttgataataa taatattatt       60

atgatggagc ctccatttgc gagaggtacg gggagatatt ataaagcttt taaaatcaca      120

gatcgtattt ggataatacc ggaaagatat acttttggat ataaacctga ggattttaat      180

aaaagttccg gtatttttaa tagagatgtt tgtgaatatt atgatccaga ttacttaaat      240

actaatgata aaaagaatat atttttacaa acaatgatca agttatttaa tagaatcaaa      300

tcaaaaccat tgggtgaaaa gttattagag atgattataa atggtatacc ttatcttgga      360

gatagacgtg ttccactcga agagtttaac acaaacattg ctagtgtaac tgttaataaa      420

ttaatcagta atccaggaga agtggagcga aaaaaaggta ttttcgcaaa tttaataata      480

tttggacctg ggccagtttt aaatgaaaat gagactatag atataggtat acaaaatcat      540

tttgcatcaa gggaaggctt cgggggtata atgcaaatga agttttgccc agaatatgta      600

agcgtattta ataatgttca agaaaacaaa ggcgcaagta tatttaatag acgtggatat      660

ttttcagatc cagccttgat attaatgcat gaacttatac atgttttaca tggattatat      720

ggcattaaag tagatgattt accaattgta ccaaatgaaa aaaaattttt tatgcaatct      780

acagatgcta tacaggcaga agaactatat acatttggag gacaagatcc cagcatcata      840

actccttcta cggataaaag tatctatgat aaagttttgc aaaattttag agggatagtt      900

gatagactta acaaggtttt agtttgcata tcagatccta acattaatat taatatatat      960

aaaaataaat ttaaagataa atataaattc gttgaagatt ctgagggaaa atatagtata     1020

gatgtagaaa gttttgataa attatataaa agcttaatgt ttggttttac agaaactaat     1080

atagcagaaa attataaaat aaaaactaga gcttcttatt ttagtgattc cttaccacca     1140

gtaaaaataa aaaatttatt agataatgaa atctatacta tagaggaagg gtttaatata     1200

tctgataaag atatggaaaa agaatataga ggtcagaata aagctataaa taaacaagct     1260

tatgaagaaa ttagcaagga gcatttggct gtatataaga tacaaatgtg taaaagtgtt     1320

aaagctccag gaatatgtat tgatgttgat aatgaagatt tgttctttat agctgataaa     1380

aatagttttt cagatgattt atctaaaaac gaaagaatag aatataatac acagagtaat     1440

tatatagaaa atgacttccc tataaatgaa ttaattttag atactgattt aataagtaaa     1500

atagaattac caagtgaaaa tacagaatca cttactgatt ttaatgtaga tgttccagta     1560

tatgaaaaac aacccgctat aaaaaaaatt tttacagatg aaaataccat ctttcaatat     1620

ttatactctc agacatttcc tctagatata agagatataa gtttaacatc ttcatttgat     1680

gatgcattat tattttctaa caaagtttat tcattttttt ctatggatta tattaaaact     1740

gctaataaag tggtagaagc aggattattt gcaggttggg tgaaacagat agtaaatgat     1800

tttgtaatcg aagctaataa aagcaatact atggataaaa ttgcagatat atctctaatt     1860

gttccttata taggattagc tttaaatgta ggaaatgaaa cagctaaagg aaattttgaa     1920

aatgcttttg agattgcagg agccagtatt ctactagaat ttataccaga acttttaata     1980

cctgtagttg gagccttttt attagaatca tatattgaca ataaaaataa aattattaaa     2040

acaatagata atgctttaac taaaagaaat gaaaaatgga gtgatatgta cggattaata     2100

gtagcgcaat ggctctcaac agttaatact caattttata caataaaaga gggaatgtat     2160

aaggctttaa attatcaagc acaagcattg gaagaaataa taaaatacag atataatata     2220

tattctgaaa aagaaaagtc aaatattaac atcgatttta atgatataaa ttctaaactt     2280

aatgagggta ttaaccaagc tatagataat ataaataatt ttataaatgg atgttctgta     2340

tcatatttaa tgaaaaaaat gattccatta gctgtagaaa aattactaga ctttgataat     2400

actctcaaaa aaaatttgtt aaattatata gatgaaaata aattatattt gattggaagt     2460

gcagaatatg aaaaatcaaa agtaaataaa tacttgaaaa ccattatgcc gtttgatctt     2520

tcaatatata ccaatgatac aatactaata gaaatgttta ataaatataa tagcgaaatt     2580

ttaaataata ttatcttaaa tttaagatat aaggataata atttaataga tttatcagga     2640

tatggggcaa aggtagaggt atatgatgga gtcgagctta atgataaaaa tcaatttaaa     2700

ttaactagtt cagcaaatag taagattaga gtgactcaaa atcagaatat catatttaat     2760

agtgtgttcc ttgattttag cgttagcttt tggataagaa tacctaaata taagaatgat     2820

ggtatacaaa attatattca taatgaatat acaataatta attgtatgaa aaataattcg     2880

ggctggaaaa tatctattag gggtaatagg ataatatgga ctttaattga tataaatgga     2940

aaaaccaaat cggtattttt tgaatataac ataagagaag atatatcaga gtatataaat     3000

agatggtttt ttgtaactat tactaataat ttgaataacg ctaaaattta tattaatggt     3060

aagctagaat caaatacaga tattaaagat ataagagaag ttattgctaa tggtgaaata     3120

atatttaaat tagatggtga tatagataga acacaattta tttggatgaa atatttcagt     3180

atttttaata cggaattaag tcaatcaaat attgaagaaa gatataaaat tcaatcatat     3240

agcgaatatt taaaagattt ttggggaaat cctttaatgt acaataaaga atattatatg     3300

tttaatgcgg ggaataaaaa ttcatatatt aaactaaaga aagattcacc tgtaggtgaa     3360

attttaacac gtagcaaata taatcaaaat tctaaatata taaattatag agatttatat     3420

attggagaaa aatttattat aagaagaaag tcaaattctc aatctataaa tgatgatata     3480

gttagaaaag aagattatat atatctagat ttttttaatt taaatcaaga gtggagagta     3540

tatacctata aatattttaa gaaagaggaa gaaaaattgt ttttagctcc tataagtgat     3600

tctgatgagt tttacaatac tatacaaata aaagaatatg atgaacagcc aacatatagt     3660

tgtcagttgc tttttaaaaa agatgaagaa agtactgatg agataggatt gattggtatt     3720

catcgtttct acgaatctgg aattgtattt gaagagtata aagattattt ttgtataagt     3780

aaatggtact taaaagaggt aaaaaggaaa ccatataatt taaaattggg atgtaattgg     3840

cagtttattc ctaaagatga agggtggact gaataa                               3876


<210> 4
<211> 1291
<212> PRT
<213> Clostridium botulinum


<400> 4
Met Pro Val Thr Ile Asn Asn Phe Asn Tyr Asn Asp Pro Ile Asp Asn 
1               5                   10                  15      
Asn Asn Ile Ile Met Met Glu Pro Pro Phe Ala Arg Gly Thr Gly Arg 
            20                  25                  30          
Tyr Tyr Lys Ala Phe Lys Ile Thr Asp Arg Ile Trp Ile Ile Pro Glu 
        35                  40                  45              
Arg Tyr Thr Phe Gly Tyr Lys Pro Glu Asp Phe Asn Lys Ser Ser Gly 
    50                  55                  60                  
Ile Phe Asn Arg Asp Val Cys Glu Tyr Tyr Asp Pro Asp Tyr Leu Asn 
65                  70                  75                  80  
Thr Asn Asp Lys Lys Asn Ile Phe Leu Gln Thr Met Ile Lys Leu Phe 
                85                  90                  95      
Asn Arg Ile Lys Ser Lys Pro Leu Gly Glu Lys Leu Leu Glu Met Ile 
            100                 105                 110         
Ile Asn Gly Ile Pro Tyr Leu Gly Asp Arg Arg Val Pro Leu Glu Glu 
        115                 120                 125             
Phe Asn Thr Asn Ile Ala Ser Val Thr Val Asn Lys Leu Ile Ser Asn 
    130                 135                 140                 
Pro Gly Glu Val Glu Arg Lys Lys Gly Ile Phe Ala Asn Leu Ile Ile 
145                 150                 155                 160 
Phe Gly Pro Gly Pro Val Leu Asn Glu Asn Glu Thr Ile Asp Ile Gly 
                165                 170                 175     
Ile Gln Asn His Phe Ala Ser Arg Glu Gly Phe Gly Gly Ile Met Gln 
            180                 185                 190         
Met Lys Phe Cys Pro Glu Tyr Val Ser Val Phe Asn Asn Val Gln Glu 
        195                 200                 205             
Asn Lys Gly Ala Ser Ile Phe Asn Arg Arg Gly Tyr Phe Ser Asp Pro 
    210                 215                 220                 
Ala Leu Ile Leu Met His Glu Leu Ile His Val Leu His Gly Leu Tyr 
225                 230                 235                 240 
Gly Ile Lys Val Asp Asp Leu Pro Ile Val Pro Asn Glu Lys Lys Phe 
                245                 250                 255     
Phe Met Gln Ser Thr Asp Ala Ile Gln Ala Glu Glu Leu Tyr Thr Phe 
            260                 265                 270         
Gly Gly Gln Asp Pro Ser Ile Ile Thr Pro Ser Thr Asp Lys Ser Ile 
        275                 280                 285             
Tyr Asp Lys Val Leu Gln Asn Phe Arg Gly Ile Val Asp Arg Leu Asn 
    290                 295                 300                 
Lys Val Leu Val Cys Ile Ser Asp Pro Asn Ile Asn Ile Asn Ile Tyr 
305                 310                 315                 320 
Lys Asn Lys Phe Lys Asp Lys Tyr Lys Phe Val Glu Asp Ser Glu Gly 
                325                 330                 335     
Lys Tyr Ser Ile Asp Val Glu Ser Phe Asp Lys Leu Tyr Lys Ser Leu 
            340                 345                 350         
Met Phe Gly Phe Thr Glu Thr Asn Ile Ala Glu Asn Tyr Lys Ile Lys 
        355                 360                 365             
Thr Arg Ala Ser Tyr Phe Ser Asp Ser Leu Pro Pro Val Lys Ile Lys 
    370                 375                 380                 
Asn Leu Leu Asp Asn Glu Ile Tyr Thr Ile Glu Glu Gly Phe Asn Ile 
385                 390                 395                 400 
Ser Asp Lys Asp Met Glu Lys Glu Tyr Arg Gly Gln Asn Lys Ala Ile 
                405                 410                 415     
Asn Lys Gln Ala Tyr Glu Glu Ile Ser Lys Glu His Leu Ala Val Tyr 
            420                 425                 430         
Lys Ile Gln Met Cys Lys Ser Val Lys Ala Pro Gly Ile Cys Ile Asp 
        435                 440                 445             
Val Asp Asn Glu Asp Leu Phe Phe Ile Ala Asp Lys Asn Ser Phe Ser 
    450                 455                 460                 
Asp Asp Leu Ser Lys Asn Glu Arg Ile Glu Tyr Asn Thr Gln Ser Asn 
465                 470                 475                 480 
Tyr Ile Glu Asn Asp Phe Pro Ile Asn Glu Leu Ile Leu Asp Thr Asp 
                485                 490                 495     
Leu Ile Ser Lys Ile Glu Leu Pro Ser Glu Asn Thr Glu Ser Leu Thr 
            500                 505                 510         
Asp Phe Asn Val Asp Val Pro Val Tyr Glu Lys Gln Pro Ala Ile Lys 
        515                 520                 525             
Lys Ile Phe Thr Asp Glu Asn Thr Ile Phe Gln Tyr Leu Tyr Ser Gln 
    530                 535                 540                 
Thr Phe Pro Leu Asp Ile Arg Asp Ile Ser Leu Thr Ser Ser Phe Asp 
545                 550                 555                 560 
Asp Ala Leu Leu Phe Ser Asn Lys Val Tyr Ser Phe Phe Ser Met Asp 
                565                 570                 575     
Tyr Ile Lys Thr Ala Asn Lys Val Val Glu Ala Gly Leu Phe Ala Gly 
            580                 585                 590         
Trp Val Lys Gln Ile Val Asn Asp Phe Val Ile Glu Ala Asn Lys Ser 
        595                 600                 605             
Asn Thr Met Asp Lys Ile Ala Asp Ile Ser Leu Ile Val Pro Tyr Ile 
    610                 615                 620                 
Gly Leu Ala Leu Asn Val Gly Asn Glu Thr Ala Lys Gly Asn Phe Glu 
625                 630                 635                 640 
Asn Ala Phe Glu Ile Ala Gly Ala Ser Ile Leu Leu Glu Phe Ile Pro 
                645                 650                 655     
Glu Leu Leu Ile Pro Val Val Gly Ala Phe Leu Leu Glu Ser Tyr Ile 
            660                 665                 670         
Asp Asn Lys Asn Lys Ile Ile Lys Thr Ile Asp Asn Ala Leu Thr Lys 
        675                 680                 685             
Arg Asn Glu Lys Trp Ser Asp Met Tyr Gly Leu Ile Val Ala Gln Trp 
    690                 695                 700                 
Leu Ser Thr Val Asn Thr Gln Phe Tyr Thr Ile Lys Glu Gly Met Tyr 
705                 710                 715                 720 
Lys Ala Leu Asn Tyr Gln Ala Gln Ala Leu Glu Glu Ile Ile Lys Tyr 
                725                 730                 735     
Arg Tyr Asn Ile Tyr Ser Glu Lys Glu Lys Ser Asn Ile Asn Ile Asp 
            740                 745                 750         
Phe Asn Asp Ile Asn Ser Lys Leu Asn Glu Gly Ile Asn Gln Ala Ile 
        755                 760                 765             
Asp Asn Ile Asn Asn Phe Ile Asn Gly Cys Ser Val Ser Tyr Leu Met 
    770                 775                 780                 
Lys Lys Met Ile Pro Leu Ala Val Glu Lys Leu Leu Asp Phe Asp Asn 
785                 790                 795                 800 
Thr Leu Lys Lys Asn Leu Leu Asn Tyr Ile Asp Glu Asn Lys Leu Tyr 
                805                 810                 815     
Leu Ile Gly Ser Ala Glu Tyr Glu Lys Ser Lys Val Asn Lys Tyr Leu 
            820                 825                 830         
Lys Thr Ile Met Pro Phe Asp Leu Ser Ile Tyr Thr Asn Asp Thr Ile 
        835                 840                 845             
Leu Ile Glu Met Phe Asn Lys Tyr Asn Ser Glu Ile Leu Asn Asn Ile 
    850                 855                 860                 
Ile Leu Asn Leu Arg Tyr Lys Asp Asn Asn Leu Ile Asp Leu Ser Gly 
865                 870                 875                 880 
Tyr Gly Ala Lys Val Glu Val Tyr Asp Gly Val Glu Leu Asn Asp Lys 
                885                 890                 895     
Asn Gln Phe Lys Leu Thr Ser Ser Ala Asn Ser Lys Ile Arg Val Thr 
            900                 905                 910         
Gln Asn Gln Asn Ile Ile Phe Asn Ser Val Phe Leu Asp Phe Ser Val 
        915                 920                 925             
Ser Phe Trp Ile Arg Ile Pro Lys Tyr Lys Asn Asp Gly Ile Gln Asn 
    930                 935                 940                 
Tyr Ile His Asn Glu Tyr Thr Ile Ile Asn Cys Met Lys Asn Asn Ser 
945                 950                 955                 960 
Gly Trp Lys Ile Ser Ile Arg Gly Asn Arg Ile Ile Trp Thr Leu Ile 
                965                 970                 975     
Asp Ile Asn Gly Lys Thr Lys Ser Val Phe Phe Glu Tyr Asn Ile Arg 
            980                 985                 990         
Glu Asp Ile Ser Glu Tyr Ile Asn Arg Trp Phe Phe Val Thr Ile Thr 
        995                 1000                1005            
Asn Asn Leu Asn Asn Ala Lys Ile Tyr Ile Asn Gly Lys Leu Glu Ser 
    1010                1015                1020                
Asn Thr Asp Ile Lys Asp Ile Arg Glu Val Ile Ala Asn Gly Glu Ile 
1025                1030                1035                1040
Ile Phe Lys Leu Asp Gly Asp Ile Asp Arg Thr Gln Phe Ile Trp Met 
                1045                1050                1055    
Lys Tyr Phe Ser Ile Phe Asn Thr Glu Leu Ser Gln Ser Asn Ile Glu 
            1060                1065                1070        
Glu Arg Tyr Lys Ile Gln Ser Tyr Ser Glu Tyr Leu Lys Asp Phe Trp 
        1075                1080                1085            
Gly Asn Pro Leu Met Tyr Asn Lys Glu Tyr Tyr Met Phe Asn Ala Gly 
    1090                1095                1100                
Asn Lys Asn Ser Tyr Ile Lys Leu Lys Lys Asp Ser Pro Val Gly Glu 
1105                1110                1115                1120
Ile Leu Thr Arg Ser Lys Tyr Asn Gln Asn Ser Lys Tyr Ile Asn Tyr 
                1125                1130                1135    
Arg Asp Leu Tyr Ile Gly Glu Lys Phe Ile Ile Arg Arg Lys Ser Asn 
            1140                1145                1150        
Ser Gln Ser Ile Asn Asp Asp Ile Val Arg Lys Glu Asp Tyr Ile Tyr 
        1155                1160                1165            
Leu Asp Phe Phe Asn Leu Asn Gln Glu Trp Arg Val Tyr Thr Tyr Lys 
    1170                1175                1180                
Tyr Phe Lys Lys Glu Glu Glu Lys Leu Phe Leu Ala Pro Ile Ser Asp 
1185                1190                1195                1200
Ser Asp Glu Phe Tyr Asn Thr Ile Gln Ile Lys Glu Tyr Asp Glu Gln 
                1205                1210                1215    
Pro Thr Tyr Ser Cys Gln Leu Leu Phe Lys Lys Asp Glu Glu Ser Thr 
            1220                1225                1230        
Asp Glu Ile Gly Leu Ile Gly Ile His Arg Phe Tyr Glu Ser Gly Ile 
        1235                1240                1245            
Val Phe Glu Glu Tyr Lys Asp Tyr Phe Cys Ile Ser Lys Trp Tyr Leu 
    1250                1255                1260                
Lys Glu Val Lys Arg Lys Pro Tyr Asn Leu Lys Leu Gly Cys Asn Trp 
1265                1270                1275                1280
Gln Phe Ile Pro Lys Asp Glu Gly Trp Thr Glu 
                1285                1290    

<210> 5
<211> 3843
<212> DNA
<213> Clostridium botulinum


<400> 5
atgccaataa caattaacaa ctttaattat tcagatcctg ttgataataa aaatatttta       60

tatttagata ctcatttaaa tacattagct aatgagcctg aaaaagcctt tcgcattata      120

gggaatatat gggtaatacc cgatagattt tcaagagatt ctaatccaaa tttaaataaa      180

cctcctcgag ttacaagccc taaaagtggt tattatgatc ctaattattt gagtactgat      240

tctgaaaaag atacattttt aaaagaaatt ataaagttat ttaaaagaat taactctaga      300

gaaataggag aagaattaat atatagactt gcaacagaca taccctttcc tgggaataac      360

aatactccaa ttaatacttt tgattttgat gtagatttta acagtgttga tgttaaaact      420

agacaaggta acaactgggt taaaactggt agtataaatc ctagtgttat aataactgga      480

cctagagaaa acattataga cccagaaact tctacgttta aattaactaa caatactttt      540

gcggcacaag aaggatttgg tgctttatca ataatttcaa tatcacctag atttatgcta      600

acatatagta atgcaactaa taatgtagga gagggtagat tttctaagtc tgaattttgc      660

atggatccaa tactaatttt aatgcatgaa cttaatcatg caatgcataa tttatatgga      720

atagctatac caaatgatca aagaatttca tctgtaacta gtaatatttt ttattctcaa      780

tataaggtga aattagagta tgcagaaata tatgcatttg gaggtccaac tatagacctt      840

attcctaaaa gtgcaaggaa atattttgag gaaaaggcat tggattatta tagatccata      900

gctaaaagac ttaatagtat aactactgca aatccttcaa gctttaataa atatatagga      960

gaatataaac agaaacttat tagaaagtat agattcgtag tagaatcttc aggtgaagtt     1020

gcagtagatc gtaataagtt tgctgagtta tataaagaac ttacacaaat atttacagaa     1080

tttaactacg ctaaaatata taatgtacaa aataggaaaa tatatctttc aaatgtatat     1140

actccggtta cggcaaatat attagacgat aatgtttatg atatacaaaa tggatttaac     1200

atacctaaaa gtaatttaaa tgtactattt atgggtcaaa atttatctcg aaatccagca     1260

ttaagaaaag tcaatcctga aaatatgctt tatttattta caaaattttg ccataaagca     1320

atagatggta gatcattata taataaaaca ttagattgta gagagctttt agttaaaaat     1380

actgacttac cctttatagg tgatattagt gatatcaaaa ctgatatatt tttaagcaaa     1440

gatattaatg aagaaactga agttatagac tatccggaca atgtttcagt ggatcaagtt     1500

attctcagta agaatacctc agaacatgga caactagatt tattataccc tattattgaa     1560

ggtgagagtc aagtattacc gggagagaat caagtctttt atgataatag aactcaaaat     1620

gttgattatt tgaattctta ttattaccta gaatctcaaa aactaagtga taatgttgaa     1680

gattttactt ttacgacatc aattgaggaa gctttggata atagtggaaa agtatatact     1740

tactttccta aactagctga taaagtaaat acgggtgttc aaggtggttt atttttaatg     1800

tgggcaaatg atgtagttga agattttact acaaatattc taagaaaaga tacattagat     1860

aaaatatcag atgtatcagc tattattccc tatataggac ctgcattaaa tataagtaat     1920

tctgtaagaa ggggaaattt tactgaagca tttgcagtta ccggtgtaac tattttatta     1980

gaagcgtttc aagaatttac aatacctgca cttggtgcat ttgtgattta tagtaaggtt     2040

caagaaagaa acgagattat taaaactata gataattgtt tagaacaaag gattaaaaga     2100

tggaaagatt catatgaatg gatgatagga acgtggttat ccaggattac tactcaattt     2160

aataatataa gttatcaaat gtatgattct ttaaattatc aggcagatgc aatcaaagat     2220

aaaatagatt tagaatataa aaaatactca ggaagtgata aagaaaatat aaaaagtcaa     2280

gttgaaaatt taaaaaatag tttagatata aaaatctcgg aagcaatgaa taatataaat     2340

aaatttatac gagaatgttc tgtaacatac ttatttaaaa atatgctccc taaagtaatt     2400

gatgaattaa ataagtttga tttaaaaact aaaacagaat taattaatct tatagatagt     2460

cataatatta ttctagttgg tgaagtagat agattaaaag caaaagtaaa tgagagtttt     2520

gaaaatacaa taccctttaa tattttttca tatactaata attctttatt aaaagatata     2580

attaatgaat atttcaatag tattaatgat tcaaaaattt tgagcttaca aaacaaaaaa     2640

aatgctttag tggatacatc aggatataat gcagaagtga ggctagaagg tgatgttcaa     2700

gttaatacga tatatacaaa tgattttaaa ttaagtagtt caggagataa aattatagta     2760

aatttaaata ataatatttt atatagcgct atttatgaga actctagtgt tagtttttgg     2820

attaagatat ctaaagattt aactaattct cataatgaat atacaataat taatagtata     2880

aaacaaaatt ctgggtggaa attatgtatt aggaatggca atatagaatg gattttacaa     2940

gatattaata gaaagtataa aagtttaatt tttgattata gtgaatcatt aagtcataca     3000

ggatatacaa ataaatggtt ttttgttact ataactaata atataatggg gtatatgaaa     3060

ctttatataa atggagaatt aaagcagagt gaaagaattg aagatttaaa tgaggttaag     3120

ttagataaaa ccatagtatt tggaatagat gagaatatag atgagaatca gatgctttgg     3180

attagagatt ttaatatttt ttctaaagaa ttaagcaatg aagatattaa tattgtatat     3240

gagggacaaa tattaagaaa tgttattaaa gattattggg gaaatccttt gaagtttgat     3300

acagaatatt atattattaa tgataattat atagataggt atatagcacc taaaagtaat     3360

atacttgtac ttgttcagta tccagataga tctaaattat atactggaaa tcctattact     3420

attaaatcag tatctgataa gaatccttat agtagaattt taaatggaga taatataatg     3480

tttcatatgt tatataatag tgggaaatat atgataataa gagatactga tacaatatat     3540

gcaatagaag gaagagagtg ttcaaaaaat tgtgtatatg cattaaaatt acagagtaat     3600

ttaggtaatt atggtatagg tatatttagt ataaaaaata ttgtatctca aaataaatat     3660

tgtagtcaaa ttttctctag ttttatgaaa aatacaatgc ttctagcaga tatatataaa     3720

ccttggagat tttcttttga aaatgcatac acgccagttg cagtaactaa ttatgagaca     3780

aaactattat caacttcatc tttttggaaa tttatttcta gggatccagg atgggtagag     3840

taa                                                                   3843


<210> 6
<211> 1280
<212> PRT
<213> Clostridium botulinum


<400> 6
Met Pro Ile Thr Ile Asn Asn Phe Asn Tyr Ser Asp Pro Val Asp Asn 
1               5                   10                  15      
Lys Asn Ile Leu Tyr Leu Asp Thr His Leu Asn Thr Leu Ala Asn Glu 
            20                  25                  30          
Pro Glu Lys Ala Phe Arg Ile Ile Gly Asn Ile Trp Val Ile Pro Asp 
        35                  40                  45              
Arg Phe Ser Arg Asp Ser Asn Pro Asn Leu Asn Lys Pro Pro Arg Val 
    50                  55                  60                  
Thr Ser Pro Lys Ser Gly Tyr Tyr Asp Pro Asn Tyr Leu Ser Thr Asp 
65                  70                  75                  80  
Ser Glu Lys Asp Thr Phe Leu Lys Glu Ile Ile Lys Leu Phe Lys Arg 
                85                  90                  95      
Ile Asn Ser Arg Glu Ile Gly Glu Glu Leu Ile Tyr Arg Leu Ala Thr 
            100                 105                 110         
Asp Ile Pro Phe Pro Gly Asn Asn Asn Thr Pro Ile Asn Thr Phe Asp 
        115                 120                 125             
Phe Asp Val Asp Phe Asn Ser Val Asp Val Lys Thr Arg Gln Gly Asn 
    130                 135                 140                 
Asn Trp Val Lys Thr Gly Ser Ile Asn Pro Ser Val Ile Ile Thr Gly 
145                 150                 155                 160 
Pro Arg Glu Asn Ile Ile Asp Pro Glu Thr Ser Thr Phe Lys Leu Thr 
                165                 170                 175     
Asn Asn Thr Phe Ala Ala Gln Glu Gly Phe Gly Ala Leu Ser Ile Ile 
            180                 185                 190         
Ser Ile Ser Pro Arg Phe Met Leu Thr Tyr Ser Asn Ala Thr Asn Asn 
        195                 200                 205             
Val Gly Glu Gly Arg Phe Ser Lys Ser Glu Phe Cys Met Asp Pro Ile 
    210                 215                 220                 
Leu Ile Leu Met His Glu Leu Asn His Ala Met His Asn Leu Tyr Gly 
225                 230                 235                 240 
Ile Ala Ile Pro Asn Asp Gln Arg Ile Ser Ser Val Thr Ser Asn Ile 
                245                 250                 255     
Phe Tyr Ser Gln Tyr Lys Val Lys Leu Glu Tyr Ala Glu Ile Tyr Ala 
            260                 265                 270         
Phe Gly Gly Pro Thr Ile Asp Leu Ile Pro Lys Ser Ala Arg Lys Tyr 
        275                 280                 285             
Phe Glu Glu Lys Ala Leu Asp Tyr Tyr Arg Ser Ile Ala Lys Arg Leu 
    290                 295                 300                 
Asn Ser Ile Thr Thr Ala Asn Pro Ser Ser Phe Asn Lys Tyr Ile Gly 
305                 310                 315                 320 
Glu Tyr Lys Gln Lys Leu Ile Arg Lys Tyr Arg Phe Val Val Glu Ser 
                325                 330                 335     
Ser Gly Glu Val Ala Val Asp Arg Asn Lys Phe Ala Glu Leu Tyr Lys 
            340                 345                 350         
Glu Leu Thr Gln Ile Phe Thr Glu Phe Asn Tyr Ala Lys Ile Tyr Asn 
        355                 360                 365             
Val Gln Asn Arg Lys Ile Tyr Leu Ser Asn Val Tyr Thr Pro Val Thr 
    370                 375                 380                 
Ala Asn Ile Leu Asp Asp Asn Val Tyr Asp Ile Gln Asn Gly Phe Asn 
385                 390                 395                 400 
Ile Pro Lys Ser Asn Leu Asn Val Leu Phe Met Gly Gln Asn Leu Ser 
                405                 410                 415     
Arg Asn Pro Ala Leu Arg Lys Val Asn Pro Glu Asn Met Leu Tyr Leu 
            420                 425                 430         
Phe Thr Lys Phe Cys His Lys Ala Ile Asp Gly Arg Ser Leu Tyr Asn 
        435                 440                 445             
Lys Thr Leu Asp Cys Arg Glu Leu Leu Val Lys Asn Thr Asp Leu Pro 
    450                 455                 460                 
Phe Ile Gly Asp Ile Ser Asp Ile Lys Thr Asp Ile Phe Leu Ser Lys 
465                 470                 475                 480 
Asp Ile Asn Glu Glu Thr Glu Val Ile Asp Tyr Pro Asp Asn Val Ser 
                485                 490                 495     
Val Asp Gln Val Ile Leu Ser Lys Asn Thr Ser Glu His Gly Gln Leu 
            500                 505                 510         
Asp Leu Leu Tyr Pro Ile Ile Glu Gly Glu Ser Gln Val Leu Pro Gly 
        515                 520                 525             
Glu Asn Gln Val Phe Tyr Asp Asn Arg Thr Gln Asn Val Asp Tyr Leu 
    530                 535                 540                 
Asn Ser Tyr Tyr Tyr Leu Glu Ser Gln Lys Leu Ser Asp Asn Val Glu 
545                 550                 555                 560 
Asp Phe Thr Phe Thr Thr Ser Ile Glu Glu Ala Leu Asp Asn Ser Gly 
                565                 570                 575     
Lys Val Tyr Thr Tyr Phe Pro Lys Leu Ala Asp Lys Val Asn Thr Gly 
            580                 585                 590         
Val Gln Gly Gly Leu Phe Leu Met Trp Ala Asn Asp Val Val Glu Asp 
        595                 600                 605             
Phe Thr Thr Asn Ile Leu Arg Lys Asp Thr Leu Asp Lys Ile Ser Asp 
    610                 615                 620                 
Val Ser Ala Ile Ile Pro Tyr Ile Gly Pro Ala Leu Asn Ile Ser Asn 
625                 630                 635                 640 
Ser Val Arg Arg Gly Asn Phe Thr Glu Ala Phe Ala Val Thr Gly Val 
                645                 650                 655     
Thr Ile Leu Leu Glu Ala Phe Gln Glu Phe Thr Ile Pro Ala Leu Gly 
            660                 665                 670         
Ala Phe Val Ile Tyr Ser Lys Val Gln Glu Arg Asn Glu Ile Ile Lys 
        675                 680                 685             
Thr Ile Asp Asn Cys Leu Glu Gln Arg Ile Lys Arg Trp Lys Asp Ser 
    690                 695                 700                 
Tyr Glu Trp Met Ile Gly Thr Trp Leu Ser Arg Ile Thr Thr Gln Phe 
705                 710                 715                 720 
Asn Asn Ile Ser Tyr Gln Met Tyr Asp Ser Leu Asn Tyr Gln Ala Asp 
                725                 730                 735     
Ala Ile Lys Asp Lys Ile Asp Leu Glu Tyr Lys Lys Tyr Ser Gly Ser 
            740                 745                 750         
Asp Lys Glu Asn Ile Lys Ser Gln Val Glu Asn Leu Lys Asn Ser Leu 
        755                 760                 765             
Asp Ile Lys Ile Ser Glu Ala Met Asn Asn Ile Asn Lys Phe Ile Arg 
    770                 775                 780                 
Glu Cys Ser Val Thr Tyr Leu Phe Lys Asn Met Leu Pro Lys Val Ile 
785                 790                 795                 800 
Asp Glu Leu Asn Lys Phe Asp Leu Lys Thr Lys Thr Glu Leu Ile Asn 
                805                 810                 815     
Leu Ile Asp Ser His Asn Ile Ile Leu Val Gly Glu Val Asp Arg Leu 
            820                 825                 830         
Lys Ala Lys Val Asn Glu Ser Phe Glu Asn Thr Ile Pro Phe Asn Ile 
        835                 840                 845             
Phe Ser Tyr Thr Asn Asn Ser Leu Leu Lys Asp Ile Ile Asn Glu Tyr 
    850                 855                 860                 
Phe Asn Ser Ile Asn Asp Ser Lys Ile Leu Ser Leu Gln Asn Lys Lys 
865                 870                 875                 880 
Asn Ala Leu Val Asp Thr Ser Gly Tyr Asn Ala Glu Val Arg Leu Glu 
                885                 890                 895     
Gly Asp Val Gln Val Asn Thr Ile Tyr Thr Asn Asp Phe Lys Leu Ser 
            900                 905                 910         
Ser Ser Gly Asp Lys Ile Ile Val Asn Leu Asn Asn Asn Ile Leu Tyr 
        915                 920                 925             
Ser Ala Ile Tyr Glu Asn Ser Ser Val Ser Phe Trp Ile Lys Ile Ser 
    930                 935                 940                 
Lys Asp Leu Thr Asn Ser His Asn Glu Tyr Thr Ile Ile Asn Ser Ile 
945                 950                 955                 960 
Lys Gln Asn Ser Gly Trp Lys Leu Cys Ile Arg Asn Gly Asn Ile Glu 
                965                 970                 975     
Trp Ile Leu Gln Asp Ile Asn Arg Lys Tyr Lys Ser Leu Ile Phe Asp 
            980                 985                 990         
Tyr Ser Glu Ser Leu Ser His Thr Gly Tyr Thr Asn Lys Trp Phe Phe 
        995                 1000                1005            
Val Thr Ile Thr Asn Asn Ile Met Gly Tyr Met Lys Leu Tyr Ile Asn 
    1010                1015                1020                
Gly Glu Leu Lys Gln Ser Glu Arg Ile Glu Asp Leu Asn Glu Val Lys 
1025                1030                1035                1040
Leu Asp Lys Thr Ile Val Phe Gly Ile Asp Glu Asn Ile Asp Glu Asn 
                1045                1050                1055    
Gln Met Leu Trp Ile Arg Asp Phe Asn Ile Phe Ser Lys Glu Leu Ser 
            1060                1065                1070        
Asn Glu Asp Ile Asn Ile Val Tyr Glu Gly Gln Ile Leu Arg Asn Val 
        1075                1080                1085            
Ile Lys Asp Tyr Trp Gly Asn Pro Leu Lys Phe Asp Thr Glu Tyr Tyr 
    1090                1095                1100                
Ile Ile Asn Asp Asn Tyr Ile Asp Arg Tyr Ile Ala Pro Lys Ser Asn 
1105                1110                1115                1120
Ile Leu Val Leu Val Gln Tyr Pro Asp Arg Ser Lys Leu Tyr Thr Gly 
                1125                1130                1135    
Asn Pro Ile Thr Ile Lys Ser Val Ser Asp Lys Asn Pro Tyr Ser Arg 
            1140                1145                1150        
Ile Leu Asn Gly Asp Asn Ile Met Phe His Met Leu Tyr Asn Ser Gly 
        1155                1160                1165            
Lys Tyr Met Ile Ile Arg Asp Thr Asp Thr Ile Tyr Ala Ile Glu Gly 
    1170                1175                1180                
Arg Glu Cys Ser Lys Asn Cys Val Tyr Ala Leu Lys Leu Gln Ser Asn 
1185                1190                1195                1200
Leu Gly Asn Tyr Gly Ile Gly Ile Phe Ser Ile Lys Asn Ile Val Ser 
                1205                1210                1215    
Gln Asn Lys Tyr Cys Ser Gln Ile Phe Ser Ser Phe Met Lys Asn Thr 
            1220                1225                1230        
Met Leu Leu Ala Asp Ile Tyr Lys Pro Trp Arg Phe Ser Phe Glu Asn 
        1235                1240                1245            
Ala Tyr Thr Pro Val Ala Val Thr Asn Tyr Glu Thr Lys Leu Leu Ser 
    1250                1255                1260                
Thr Ser Ser Phe Trp Lys Phe Ile Ser Arg Asp Pro Gly Trp Val Glu 
1265                1270                1275                1280



<210> 7
<211> 3858
<212> DNA
<213> Clostridium botulinum


<400> 7
atgacatggc cagtaaaaga ttttaattat agtgatcctg ttaatgacaa tgatatatta       60

tatttaagaa taccacaaaa taagttaatt actacacctg taaaagcttt tatgattact      120

caaaatattt gggtaatacc agaaagattt tcatcagata ctaatccaag tttaagtaaa      180

ccgcctagac ctacttcaaa gtatcaaagt tattatgatc ctagttattt atctactgat      240

gagcaaaaag atacattttt aaaagggatt ataaaattat ttaaaagaat taatgaaaga      300

gatataggaa aaaaattaat aaattattta gtagttggtt caccttttat gggagattca      360

agtacgcctg aagatacatt tgattttaca cgtcatacta ctaatattgc agttgaaaag      420

tttgaaaatg gtagttggaa agtaacaaat attataacac caagtgtatt gatatttgga      480

ccacttccta atatattaga ctatacagca tcccttacat tgcaaggaca acaatcaaat      540

ccatcatttg aagggtttgg aacattatct atactaaaag tagcacctga atttttgtta      600

acatttagtg atgtaacatc taatcaaagt tcagctgtat taggcaaatc tatattttgt      660

atggatccag taatagcttt aatgcatgag ttaacacatt ctttgcatca attgtatgga      720

ataaatatac catctgataa aaggattcgt ccacaagtta gcgagggatt tttttctcaa      780

gatggaccca acgtacaatt tgaggaatta tacacatttg gaggatcaga tgttgaaata      840

atacctcaaa ttgaaagatt acaattaaga gaaaaagcat taggtcacta taaagatata      900

gcgaaaagac ttaataatat taataaaact attccttcta gttggagtag taatatagat      960

aaatataaaa aaatattttc tgaaaagtat aattttgata aagataatac aggaaatttt     1020

gttgtaaata ttgataaatt caatagctta tattcagact tgactaatgt tatgtcagaa     1080

gttgtttatt cttcgcaata taatgttaaa aacaggactc attatttttc aaagcattat     1140

ctacctgtat ttgcaaatat attagatgat aatatttata ctataataaa cggttttaat     1200

ttaacaacta aaggttttaa tatagaaaat tcgggtcaga atatagaaag gaatcctgca     1260

ctacaaaaac ttagttcaga aagtgtagta gatttgttta caaaagtatg tttaagatta     1320

acaagaaata gtagagatga ttcaacatgt attcaagtta aaaataatac attaccttat     1380

gtagctgata aagatagcat ttcacaagaa atatttgaaa gtcaaattat tacagatgag     1440

actaatgtag aaaattattc agataatttt tcattagatg aatctatttt agatgcaaaa     1500

gtccctacta atcctgaagc agtagatcca ctgttaccca atgttaatat ggaaccttta     1560

aatgttccag gtgaagaaga agtattttat gatgatatta ctaaagatgt tgattattta     1620

aactcttatt attatttgga agcccaaaaa ttaagtaata atgttgaaaa tattactctt     1680

acaacttcag ttgaagaagc attaggttat agcaataaga tatacacatt tttacctagc     1740

ttagctgaaa aagtgaataa aggtgttcaa gcaggtttat tcttaaattg ggcgaatgaa     1800

gtagttgagg attttactac aaatattatg aaaaaagata cattggataa aatatcagat     1860

gtatcagcca taattccata tataggacct gccttaaata taggaaattc agcattaagg     1920

ggaaacttta agcaagcatt tgcaacagct ggtgtagctt ttttgttaga aggatttcca     1980

gagtttacaa tacctgcact cggtgtattt accttttata gttctattca agaaagagag     2040

aaaattatta aaactataga aaattgttta gaacaaagag ttaagagatg gaaagattca     2100

tatcaatgga tggtatcaaa ttggttgtca agaattacta ctcgatttaa tcatataagt     2160

tatcaaatgt atgattcttt gagttatcag gcagatgcaa tcaaagctaa aatagattta     2220

gaatataaaa aatactcagg aagtgataaa gaaaatataa aaagtcaagt tgaaaattta     2280

aaaaatagtt tagatgtaaa aatctcggaa gcaatgaata atataaataa atttatacga     2340

gaatgttctg taacatactt atttaaaaat atgctcccta aagtaattga tgaattaaat     2400

aagtttgatt taaaaactaa aacagaatta attaatctta tagatagtca taatattatt     2460

ctagttggtg aagtagatag attaaaagca aaagtaaatg agagttttga aaatacaata     2520

ccctttaata ttttttcata tactaataat tctttattaa aagatatgat taatgaatat     2580

ttcaatagta ttaatgattc aaaaattttg agcttacaaa ataaaaaaaa tactttgatg     2640

gatacatcag gatataacgc agaagtgaga gtagaaggca atgttcagct taatccaata     2700

tttccatttg actttaaatt aggtagttca ggggatgata gaggtaaagt tatagtaacc     2760

cagaatgaaa atattgtata taatgctatg tatgaaagtt ttagtattag tttttggatt     2820

aggataaata aatgggtaag taatttacct ggatatacta taattgatag tgttaaaaat     2880

aactcaggtt ggagtatagg tattattagt aattttttag tgtttacttt aaaacaaaat     2940

gaaaatagtg aacaagatat aaactttagt tatgatatat caaagaatgc tgcgggatat     3000

aataaatggt tttttgtaac tattactacc aatatgatgg gaaatatgat gatttatata     3060

aatggaaaat taatagatac tataaaagtt aaagagttaa ctggaattaa ttttagcaaa     3120

actataacat ttcaaatgaa taaaattcca aatactggct taattacctc agattctgat     3180

aacatcaata tgtggataag ggatttttat atctttgcta aagaattaga tgataaagat     3240

attaatatat tatttaatag cttgcaatat actaatgttg taaaagatta ttggggaaat     3300

gatttaagat atgataaaga atattacatg attaacgtaa attatatgaa tagatatatg     3360

tctaaaaaag gcaatggaat tgtttttaat acacgtaaaa ataataatga cttcaatgaa     3420

ggatataaaa ttataataaa aagaattaga ggaaatacaa atgatactag agtacgagga     3480

gaaaatgtat tatattttaa tactacaatt gataacaaac aatatagttt aggtatgtat     3540

aaaccttcta gaaatctagg gactgattta gttccactag gtgcattgga tcaaccaatg     3600

gatgagatac gtaaatatgg ttcgtttata atacaaccat gcaatacttt tgattactat     3660

gcatcacaat tatttttgtc aagtaatgca acaacaaata ggcttggaat actatcaatt     3720

ggtagttata gtttcaaact tggagatgac tattggttta atcacgaata tttaattcct     3780

gttataaaaa tagagcatta tgcttcatta ttagaatcaa catcaactca ttgggttttt     3840

gtacctgcaa gtgaataa                                                   3858


<210> 8
<211> 1285
<212> PRT
<213> Clostridium botulinum


<400> 8
Met Thr Trp Pro Val Lys Asp Phe Asn Tyr Ser Asp Pro Val Asn Asp 
1               5                   10                  15      
Asn Asp Ile Leu Tyr Leu Arg Ile Pro Gln Asn Lys Leu Ile Thr Thr 
            20                  25                  30          
Pro Val Lys Ala Phe Met Ile Thr Gln Asn Ile Trp Val Ile Pro Glu 
        35                  40                  45              
Arg Phe Ser Ser Asp Thr Asn Pro Ser Leu Ser Lys Pro Pro Arg Pro 
    50                  55                  60                  
Thr Ser Lys Tyr Gln Ser Tyr Tyr Asp Pro Ser Tyr Leu Ser Thr Asp 
65                  70                  75                  80  
Glu Gln Lys Asp Thr Phe Leu Lys Gly Ile Ile Lys Leu Phe Lys Arg 
                85                  90                  95      
Ile Asn Glu Arg Asp Ile Gly Lys Lys Leu Ile Asn Tyr Leu Val Val 
            100                 105                 110         
Gly Ser Pro Phe Met Gly Asp Ser Ser Thr Pro Glu Asp Thr Phe Asp 
        115                 120                 125             
Phe Thr Arg His Thr Thr Asn Ile Ala Val Glu Lys Phe Glu Asn Gly 
    130                 135                 140                 
Ser Trp Lys Val Thr Asn Ile Ile Thr Pro Ser Val Leu Ile Phe Gly 
145                 150                 155                 160 
Pro Leu Pro Asn Ile Leu Asp Tyr Thr Ala Ser Leu Thr Leu Gln Gly 
                165                 170                 175     
Gln Gln Ser Asn Pro Ser Phe Glu Gly Phe Gly Thr Leu Ser Ile Leu 
            180                 185                 190         
Lys Val Ala Pro Glu Phe Leu Leu Thr Phe Ser Asp Val Thr Ser Asn 
        195                 200                 205             
Gln Ser Ser Ala Val Leu Gly Lys Ser Ile Phe Cys Met Asp Pro Val 
    210                 215                 220                 
Ile Ala Leu Met His Glu Leu Thr His Ser Leu His Gln Leu Tyr Gly 
225                 230                 235                 240 
Ile Asn Ile Pro Ser Asp Lys Arg Ile Arg Pro Gln Val Ser Glu Gly 
                245                 250                 255     
Phe Phe Ser Gln Asp Gly Pro Asn Val Gln Phe Glu Glu Leu Tyr Thr 
            260                 265                 270         
Phe Gly Gly Ser Asp Val Glu Ile Ile Pro Gln Ile Glu Arg Leu Gln 
        275                 280                 285             
Leu Arg Glu Lys Ala Leu Gly His Tyr Lys Asp Ile Ala Lys Arg Leu 
    290                 295                 300                 
Asn Asn Ile Asn Lys Thr Ile Pro Ser Ser Trp Ser Ser Asn Ile Asp 
305                 310                 315                 320 
Lys Tyr Lys Lys Ile Phe Ser Glu Lys Tyr Asn Phe Asp Lys Asp Asn 
                325                 330                 335     
Thr Gly Asn Phe Val Val Asn Ile Asp Lys Phe Asn Ser Leu Tyr Ser 
            340                 345                 350         
Asp Leu Thr Asn Val Met Ser Glu Val Val Tyr Ser Ser Gln Tyr Asn 
        355                 360                 365             
Val Lys Asn Arg Thr His Tyr Phe Ser Lys His Tyr Leu Pro Val Phe 
    370                 375                 380                 
Ala Asn Ile Leu Asp Asp Asn Ile Tyr Thr Ile Ile Asn Gly Phe Asn 
385                 390                 395                 400 
Leu Thr Thr Lys Gly Phe Asn Ile Glu Asn Ser Gly Gln Asn Ile Glu 
                405                 410                 415     
Arg Asn Pro Ala Leu Gln Lys Leu Ser Ser Glu Ser Val Val Asp Leu 
            420                 425                 430         
Phe Thr Lys Val Cys Leu Arg Leu Thr Arg Asn Ser Arg Asp Asp Ser 
        435                 440                 445             
Thr Cys Ile Gln Val Lys Asn Asn Thr Leu Pro Tyr Val Ala Asp Lys 
    450                 455                 460                 
Asp Ser Ile Ser Gln Glu Ile Phe Glu Ser Gln Ile Ile Thr Asp Glu 
465                 470                 475                 480 
Thr Asn Val Glu Asn Tyr Ser Asp Asn Phe Ser Leu Asp Glu Ser Ile 
                485                 490                 495     
Leu Asp Ala Lys Val Pro Thr Asn Pro Glu Ala Val Asp Pro Leu Leu 
            500                 505                 510         
Pro Asn Val Asn Met Glu Pro Leu Asn Val Pro Gly Glu Glu Glu Val 
        515                 520                 525             
Phe Tyr Asp Asp Ile Thr Lys Asp Val Asp Tyr Leu Asn Ser Tyr Tyr 
    530                 535                 540                 
Tyr Leu Glu Ala Gln Lys Leu Ser Asn Asn Val Glu Asn Ile Thr Leu 
545                 550                 555                 560 
Thr Thr Ser Val Glu Glu Ala Leu Gly Tyr Ser Asn Lys Ile Tyr Thr 
                565                 570                 575     
Phe Leu Pro Ser Leu Ala Glu Lys Val Asn Lys Gly Val Gln Ala Gly 
            580                 585                 590         
Leu Phe Leu Asn Trp Ala Asn Glu Val Val Glu Asp Phe Thr Thr Asn 
        595                 600                 605             
Ile Met Lys Lys Asp Thr Leu Asp Lys Ile Ser Asp Val Ser Ala Ile 
    610                 615                 620                 
Ile Pro Tyr Ile Gly Pro Ala Leu Asn Ile Gly Asn Ser Ala Leu Arg 
625                 630                 635                 640 
Gly Asn Phe Lys Gln Ala Phe Ala Thr Ala Gly Val Ala Phe Leu Leu 
                645                 650                 655     
Glu Gly Phe Pro Glu Phe Thr Ile Pro Ala Leu Gly Val Phe Thr Phe 
            660                 665                 670         
Tyr Ser Ser Ile Gln Glu Arg Glu Lys Ile Ile Lys Thr Ile Glu Asn 
        675                 680                 685             
Cys Leu Glu Gln Arg Val Lys Arg Trp Lys Asp Ser Tyr Gln Trp Met 
    690                 695                 700                 
Val Ser Asn Trp Leu Ser Arg Ile Thr Thr Arg Phe Asn His Ile Ser 
705                 710                 715                 720 
Tyr Gln Met Tyr Asp Ser Leu Ser Tyr Gln Ala Asp Ala Ile Lys Ala 
                725                 730                 735     
Lys Ile Asp Leu Glu Tyr Lys Lys Tyr Ser Gly Ser Asp Lys Glu Asn 
            740                 745                 750         
Ile Lys Ser Gln Val Glu Asn Leu Lys Asn Ser Leu Asp Val Lys Ile 
        755                 760                 765             
Ser Glu Ala Met Asn Asn Ile Asn Lys Phe Ile Arg Glu Cys Ser Val 
    770                 775                 780                 
Thr Tyr Leu Phe Lys Asn Met Leu Pro Lys Val Ile Asp Glu Leu Asn 
785                 790                 795                 800 
Lys Phe Asp Leu Lys Thr Lys Thr Glu Leu Ile Asn Leu Ile Asp Ser 
                805                 810                 815     
His Asn Ile Ile Leu Val Gly Glu Val Asp Arg Leu Lys Ala Lys Val 
            820                 825                 830         
Asn Glu Ser Phe Glu Asn Thr Ile Pro Phe Asn Ile Phe Ser Tyr Thr 
        835                 840                 845             
Asn Asn Ser Leu Leu Lys Asp Met Ile Asn Glu Tyr Phe Asn Ser Ile 
    850                 855                 860                 
Asn Asp Ser Lys Ile Leu Ser Leu Gln Asn Lys Lys Asn Thr Leu Met 
865                 870                 875                 880 
Asp Thr Ser Gly Tyr Asn Ala Glu Val Arg Val Glu Gly Asn Val Gln 
                885                 890                 895     
Leu Asn Pro Ile Phe Pro Phe Asp Phe Lys Leu Gly Ser Ser Gly Asp 
            900                 905                 910         
Asp Arg Gly Lys Val Ile Val Thr Gln Asn Glu Asn Ile Val Tyr Asn 
        915                 920                 925             
Ala Met Tyr Glu Ser Phe Ser Ile Ser Phe Trp Ile Arg Ile Asn Lys 
    930                 935                 940                 
Trp Val Ser Asn Leu Pro Gly Tyr Thr Ile Ile Asp Ser Val Lys Asn 
945                 950                 955                 960 
Asn Ser Gly Trp Ser Ile Gly Ile Ile Ser Asn Phe Leu Val Phe Thr 
                965                 970                 975     
Leu Lys Gln Asn Glu Asn Ser Glu Gln Asp Ile Asn Phe Ser Tyr Asp 
            980                 985                 990         
Ile Ser Lys Asn Ala Ala Gly Tyr Asn Lys Trp Phe Phe Val Thr Ile 
        995                 1000                1005            
Thr Thr Asn Met Met Gly Asn Met Met Ile Tyr Ile Asn Gly Lys Leu 
    1010                1015                1020                
Ile Asp Thr Ile Lys Val Lys Glu Leu Thr Gly Ile Asn Phe Ser Lys 
1025                1030                1035                1040
Thr Ile Thr Phe Gln Met Asn Lys Ile Pro Asn Thr Gly Leu Ile Thr 
                1045                1050                1055    
Ser Asp Ser Asp Asn Ile Asn Met Trp Ile Arg Asp Phe Tyr Ile Phe 
            1060                1065                1070        
Ala Lys Glu Leu Asp Asp Lys Asp Ile Asn Ile Leu Phe Asn Ser Leu 
        1075                1080                1085            
Gln Tyr Thr Asn Val Val Lys Asp Tyr Trp Gly Asn Asp Leu Arg Tyr 
    1090                1095                1100                
Asp Lys Glu Tyr Tyr Met Ile Asn Val Asn Tyr Met Asn Arg Tyr Met 
1105                1110                1115                1120
Ser Lys Lys Gly Asn Gly Ile Val Phe Asn Thr Arg Lys Asn Asn Asn 
                1125                1130                1135    
Asp Phe Asn Glu Gly Tyr Lys Ile Ile Ile Lys Arg Ile Arg Gly Asn 
            1140                1145                1150        
Thr Asn Asp Thr Arg Val Arg Gly Glu Asn Val Leu Tyr Phe Asn Thr 
        1155                1160                1165            
Thr Ile Asp Asn Lys Gln Tyr Ser Leu Gly Met Tyr Lys Pro Ser Arg 
    1170                1175                1180                
Asn Leu Gly Thr Asp Leu Val Pro Leu Gly Ala Leu Asp Gln Pro Met 
1185                1190                1195                1200
Asp Glu Ile Arg Lys Tyr Gly Ser Phe Ile Ile Gln Pro Cys Asn Thr 
                1205                1210                1215    
Phe Asp Tyr Tyr Ala Ser Gln Leu Phe Leu Ser Ser Asn Ala Thr Thr 
            1220                1225                1230        
Asn Arg Leu Gly Ile Leu Ser Ile Gly Ser Tyr Ser Phe Lys Leu Gly 
        1235                1240                1245            
Asp Asp Tyr Trp Phe Asn His Glu Tyr Leu Ile Pro Val Ile Lys Ile 
    1250                1255                1260                
Glu His Tyr Ala Ser Leu Leu Glu Ser Thr Ser Thr His Trp Val Phe 
1265                1270                1275                1280
Val Pro Ala Ser Glu 
                1285

<210> 9
<211> 3756
<212> DNA
<213> Clostridium botulinum


<400> 9
atgccaaaaa ttaatagttt taattataat gatcctgtta atgatagaac aattttatat       60

attaaaccag gcggttgtca agaattttat aaatcattta atattatgaa aaatatttgg      120

ataattccag agagaaatgt aattggtaca accccccaag attttcatcc gcctacttca      180

ttaaaaaatg gagatagtag ttattatgac cctaattatt tacaaagtga tgaagaaaag      240

gatagatttt taaaaatagt cacaaaaata tttaatagaa taaataataa tctttcagga      300

gggattttat tagaagaact gtcaaaagct aatccatatt tagggaatga taatactcca      360

gataatcaat tccatattgg tgatgcatca gcagttgaga ttaaattctc aaatggtagc      420

caagacatac tattacctaa tgttattata atgggagcag agcctgattt atttgaaact      480

aacagttcca atatttctct aagaaataat tatatgccaa gcaatcaccg ttttggatca      540

atagctatag taacattctc acctgaatat tcttttagat ttaatgataa ttgtatgaat      600

gaatttattc aagatcctgc tcttacatta atgcatgaat taatacattc attacatgga      660

ctatatgggg ctaaagggat tactacaaag tatactataa cacaaaaaca aaatccccta      720

ataacaaata taagaggtac aaatattgaa gaattcttaa cttttggagg tactgattta      780

aacattatta ctagtgctca gtccaatgat atctatacta atcttctagc tgattataaa      840

aaaatagcgt ctaaacttag caaagtacaa gtatctaatc cactacttaa tccttataaa      900

gatgtttttg aagcaaagta tggattagat aaagatgcta gcggaattta ttcggtaaat      960

ataaacaaat ttaatgatat ttttaaaaaa ttatacagct ttacggaatt tgatttacga     1020

actaaatttc aagttaaatg taggcaaact tatattggac agtataaata cttcaaactt     1080

tcaaacttgt taaatgattc tatttataat atatcagaag gctataatat aaataattta     1140

aaggtaaatt ttagaggaca gaatgcaaat ttaaatccta gaattattac accaattaca     1200

ggtagaggac tagtaaaaaa aatcattaga ttttgtaaaa atattgtttc tgtaaaaggc     1260

ataaggaaat caatatgtat cgaaataaat aatggtgagt tattttttgt ggcttccgag     1320

aatagttata atgatgataa tataaatact cctaaagaaa ttgacgatac agtaacttca     1380

aataataatt atgaaaatga tttagatcag gttattttaa attttaatag tgaatcagca     1440

cctggacttt cagatgaaaa attaaattta actatccaaa atgatgctta tataccaaaa     1500

tatgattcta atggaacaag tgatatagaa caacatgatg ttaatgaact taatgtattt     1560

ttctatttag atgcacagaa agtgcccgaa ggtgaaaata atgtcaatct cacctcttca     1620

attgatacag cattattaga acaacctaaa atatatacat ttttttcatc agaatttatt     1680

aataatgtca ataaacctgt gcaagcagca ttatttgtaa gctggataca acaagtgtta     1740

gtagatttta ctactgaagc taaccaaaaa agtactgttg ataaaattgc agatatttct     1800

atagttgttc catatatagg tcttgcttta aatataggaa atgaagcaca aaaaggaaat     1860

tttaaagatg cacttgaatt attaggagca ggtattttat tagaatttga acccgagctt     1920

ttaattccta caattttagt attcacgata aaatcttttt taggttcatc tgataataaa     1980

aataaagtta ttaaagcaat aaataatgca ttgaaagaaa gagatgaaaa atggaaagaa     2040

gtatatagtt ttatagtatc gaattggatg actaaaatta atacacaatt taataaaaga     2100

aaagaacaaa tgtatcaagc tttacaaaat caagtaaatg caattaaaac aataatagaa     2160

tctaagtata atagttatac tttagaggaa aaaaatgagc ttacaaataa atatgatatt     2220

aagcaaatag aaaatgaact taatcaaaag gtttctatag caatgaataa tatagacagg     2280

ttcttaactg aaagttctat atcctattta atgaaaataa taaatgaagt aaaaattaat     2340

aaattaagag aatatgatga gaatgtcaaa acgtatttat tgaattatat tatacaacat     2400

ggatcaatct tgggagagag tcagcaagaa ctaaattcta tggtaactga taccctaaat     2460

aatagtattc cttttaagct ttcttcttat acagatgata aaattttaat ttcatatttt     2520

aataaattct ttaagagaat taaaagtagt tcagttttaa atatgagata taaaaatgat     2580

aaatacgtag atacttcagg atatgattca aatataaata ttaatggaga tgtatataaa     2640

tatccaacta ataaaaatca atttggaata tataatgata aacttagtga agttaatata     2700

tctcaaaatg attacattat atatgataat aaatataaaa attttagtat tagtttttgg     2760

gtaagaattc ctaactatga taataagata gtaaatgtta ataatgaata cactataata     2820

aattgtatga gagataataa ttcaggatgg aaagtatctc ttaatcataa tgaaataatt     2880

tggacattcg aagataatcg aggaattaat caaaaattag catttaacta tggtaacgca     2940

aatggtattt ctgattatat aaataagtgg atttttgtaa ctataactaa tgatagatta     3000

ggagattcta aactttatat taatggaaat ttaatagatc aaaaatcaat tttaaattta     3060

ggtaatattc atgttagtga caatatatta tttaaaatag ttaattgtag ttatacaaga     3120

tatattggta ttagatattt taatattttt gataaagaat tagatgaaac agaaattcaa     3180

actttatata gcaatgaacc taatacaaat attttgaagg atttttgggg aaattatttg     3240

ctttatgaca aagaatacta tttattaaat gtgttaaaac caaataactt tattgatagg     3300

agaaaagatt ctactttaag cattaataat ataagaagca ctattctttt agctaataga     3360

ttatatagtg gaataaaagt taaaatacaa agagttaata atagtagtac taacgataat     3420

cttgttagaa agaatgatca ggtatatatt aattttgtag ccagcaaaac tcacttattt     3480

ccattatatg ctgatacagc taccacaaat aaagagaaaa caataaaaat atcatcatct     3540

ggcaatagat ttaatcaagt agtagttatg aattcagtag gaaattgtac aatgaatttt     3600

aaaaataata atggaaataa tattgggttg ttaggtttca aggcagatac tgtcgttgct     3660

agtacttggt attatacaca tatgagagat catacaaaca gcaatggatg tttttggaac     3720

tttatttctg aagaacatgg atggcaagaa aaataa                               3756


<210> 10
<211> 1251
<212> PRT
<213> Clostridium botulinum


<400> 10
Met Pro Lys Ile Asn Ser Phe Asn Tyr Asn Asp Pro Val Asn Asp Arg 
1               5                   10                  15      
Thr Ile Leu Tyr Ile Lys Pro Gly Gly Cys Gln Glu Phe Tyr Lys Ser 
            20                  25                  30          
Phe Asn Ile Met Lys Asn Ile Trp Ile Ile Pro Glu Arg Asn Val Ile 
        35                  40                  45              
Gly Thr Thr Pro Gln Asp Phe His Pro Pro Thr Ser Leu Lys Asn Gly 
    50                  55                  60                  
Asp Ser Ser Tyr Tyr Asp Pro Asn Tyr Leu Gln Ser Asp Glu Glu Lys 
65                  70                  75                  80  
Asp Arg Phe Leu Lys Ile Val Thr Lys Ile Phe Asn Arg Ile Asn Asn 
                85                  90                  95      
Asn Leu Ser Gly Gly Ile Leu Leu Glu Glu Leu Ser Lys Ala Asn Pro 
            100                 105                 110         
Tyr Leu Gly Asn Asp Asn Thr Pro Asp Asn Gln Phe His Ile Gly Asp 
        115                 120                 125             
Ala Ser Ala Val Glu Ile Lys Phe Ser Asn Gly Ser Gln Asp Ile Leu 
    130                 135                 140                 
Leu Pro Asn Val Ile Ile Met Gly Ala Glu Pro Asp Leu Phe Glu Thr 
145                 150                 155                 160 
Asn Ser Ser Asn Ile Ser Leu Arg Asn Asn Tyr Met Pro Ser Asn His 
                165                 170                 175     
Arg Phe Gly Ser Ile Ala Ile Val Thr Phe Ser Pro Glu Tyr Ser Phe 
            180                 185                 190         
Arg Phe Asn Asp Asn Cys Met Asn Glu Phe Ile Gln Asp Pro Ala Leu 
        195                 200                 205             
Thr Leu Met His Glu Leu Ile His Ser Leu His Gly Leu Tyr Gly Ala 
    210                 215                 220                 
Lys Gly Ile Thr Thr Lys Tyr Thr Ile Thr Gln Lys Gln Asn Pro Leu 
225                 230                 235                 240 
Ile Thr Asn Ile Arg Gly Thr Asn Ile Glu Glu Phe Leu Thr Phe Gly 
                245                 250                 255     
Gly Thr Asp Leu Asn Ile Ile Thr Ser Ala Gln Ser Asn Asp Ile Tyr 
            260                 265                 270         
Thr Asn Leu Leu Ala Asp Tyr Lys Lys Ile Ala Ser Lys Leu Ser Lys 
        275                 280                 285             
Val Gln Val Ser Asn Pro Leu Leu Asn Pro Tyr Lys Asp Val Phe Glu 
    290                 295                 300                 
Ala Lys Tyr Gly Leu Asp Lys Asp Ala Ser Gly Ile Tyr Ser Val Asn 
305                 310                 315                 320 
Ile Asn Lys Phe Asn Asp Ile Phe Lys Lys Leu Tyr Ser Phe Thr Glu 
                325                 330                 335     
Phe Asp Leu Arg Thr Lys Phe Gln Val Lys Cys Arg Gln Thr Tyr Ile 
            340                 345                 350         
Gly Gln Tyr Lys Tyr Phe Lys Leu Ser Asn Leu Leu Asn Asp Ser Ile 
        355                 360                 365             
Tyr Asn Ile Ser Glu Gly Tyr Asn Ile Asn Asn Leu Lys Val Asn Phe 
    370                 375                 380                 
Arg Gly Gln Asn Ala Asn Leu Asn Pro Arg Ile Ile Thr Pro Ile Thr 
385                 390                 395                 400 
Gly Arg Gly Leu Val Lys Lys Ile Ile Arg Phe Cys Lys Asn Ile Val 
                405                 410                 415     
Ser Val Lys Gly Ile Arg Lys Ser Ile Cys Ile Glu Ile Asn Asn Gly 
            420                 425                 430         
Glu Leu Phe Phe Val Ala Ser Glu Asn Ser Tyr Asn Asp Asp Asn Ile 
        435                 440                 445             
Asn Thr Pro Lys Glu Ile Asp Asp Thr Val Thr Ser Asn Asn Asn Tyr 
    450                 455                 460                 
Glu Asn Asp Leu Asp Gln Val Ile Leu Asn Phe Asn Ser Glu Ser Ala 
465                 470                 475                 480 
Pro Gly Leu Ser Asp Glu Lys Leu Asn Leu Thr Ile Gln Asn Asp Ala 
                485                 490                 495     
Tyr Ile Pro Lys Tyr Asp Ser Asn Gly Thr Ser Asp Ile Glu Gln His 
            500                 505                 510         
Asp Val Asn Glu Leu Asn Val Phe Phe Tyr Leu Asp Ala Gln Lys Val 
        515                 520                 525             
Pro Glu Gly Glu Asn Asn Val Asn Leu Thr Ser Ser Ile Asp Thr Ala 
    530                 535                 540                 
Leu Leu Glu Gln Pro Lys Ile Tyr Thr Phe Phe Ser Ser Glu Phe Ile 
545                 550                 555                 560 
Asn Asn Val Asn Lys Pro Val Gln Ala Ala Leu Phe Val Ser Trp Ile 
                565                 570                 575     
Gln Gln Val Leu Val Asp Phe Thr Thr Glu Ala Asn Gln Lys Ser Thr 
            580                 585                 590         
Val Asp Lys Ile Ala Asp Ile Ser Ile Val Val Pro Tyr Ile Gly Leu 
        595                 600                 605             
Ala Leu Asn Ile Gly Asn Glu Ala Gln Lys Gly Asn Phe Lys Asp Ala 
    610                 615                 620                 
Leu Glu Leu Leu Gly Ala Gly Ile Leu Leu Glu Phe Glu Pro Glu Leu 
625                 630                 635                 640 
Leu Ile Pro Thr Ile Leu Val Phe Thr Ile Lys Ser Phe Leu Gly Ser 
                645                 650                 655     
Ser Asp Asn Lys Asn Lys Val Ile Lys Ala Ile Asn Asn Ala Leu Lys 
            660                 665                 670         
Glu Arg Asp Glu Lys Trp Lys Glu Val Tyr Ser Phe Ile Val Ser Asn 
        675                 680                 685             
Trp Met Thr Lys Ile Asn Thr Gln Phe Asn Lys Arg Lys Glu Gln Met 
    690                 695                 700                 
Tyr Gln Ala Leu Gln Asn Gln Val Asn Ala Ile Lys Thr Ile Ile Glu 
705                 710                 715                 720 
Ser Lys Tyr Asn Ser Tyr Thr Leu Glu Glu Lys Asn Glu Leu Thr Asn 
                725                 730                 735     
Lys Tyr Asp Ile Lys Gln Ile Glu Asn Glu Leu Asn Gln Lys Val Ser 
            740                 745                 750         
Ile Ala Met Asn Asn Ile Asp Arg Phe Leu Thr Glu Ser Ser Ile Ser 
        755                 760                 765             
Tyr Leu Met Lys Ile Ile Asn Glu Val Lys Ile Asn Lys Leu Arg Glu 
    770                 775                 780                 
Tyr Asp Glu Asn Val Lys Thr Tyr Leu Leu Asn Tyr Ile Ile Gln His 
785                 790                 795                 800 
Gly Ser Ile Leu Gly Glu Ser Gln Gln Glu Leu Asn Ser Met Val Thr 
                805                 810                 815     
Asp Thr Leu Asn Asn Ser Ile Pro Phe Lys Leu Ser Ser Tyr Thr Asp 
            820                 825                 830         
Asp Lys Ile Leu Ile Ser Tyr Phe Asn Lys Phe Phe Lys Arg Ile Lys 
        835                 840                 845             
Ser Ser Ser Val Leu Asn Met Arg Tyr Lys Asn Asp Lys Tyr Val Asp 
    850                 855                 860                 
Thr Ser Gly Tyr Asp Ser Asn Ile Asn Ile Asn Gly Asp Val Tyr Lys 
865                 870                 875                 880 
Tyr Pro Thr Asn Lys Asn Gln Phe Gly Ile Tyr Asn Asp Lys Leu Ser 
                885                 890                 895     
Glu Val Asn Ile Ser Gln Asn Asp Tyr Ile Ile Tyr Asp Asn Lys Tyr 
            900                 905                 910         
Lys Asn Phe Ser Ile Ser Phe Trp Val Arg Ile Pro Asn Tyr Asp Asn 
        915                 920                 925             
Lys Ile Val Asn Val Asn Asn Glu Tyr Thr Ile Ile Asn Cys Met Arg 
    930                 935                 940                 
Asp Asn Asn Ser Gly Trp Lys Val Ser Leu Asn His Asn Glu Ile Ile 
945                 950                 955                 960 
Trp Thr Phe Glu Asp Asn Arg Gly Ile Asn Gln Lys Leu Ala Phe Asn 
                965                 970                 975     
Tyr Gly Asn Ala Asn Gly Ile Ser Asp Tyr Ile Asn Lys Trp Ile Phe 
            980                 985                 990         
Val Thr Ile Thr Asn Asp Arg Leu Gly Asp Ser Lys Leu Tyr Ile Asn 
        995                 1000                1005            
Gly Asn Leu Ile Asp Gln Lys Ser Ile Leu Asn Leu Gly Asn Ile His 
    1010                1015                1020                
Val Ser Asp Asn Ile Leu Phe Lys Ile Val Asn Cys Ser Tyr Thr Arg 
1025                1030                1035                1040
Tyr Ile Gly Ile Arg Tyr Phe Asn Ile Phe Asp Lys Glu Leu Asp Glu 
                1045                1050                1055    
Thr Glu Ile Gln Thr Leu Tyr Ser Asn Glu Pro Asn Thr Asn Ile Leu 
            1060                1065                1070        
Lys Asp Phe Trp Gly Asn Tyr Leu Leu Tyr Asp Lys Glu Tyr Tyr Leu 
        1075                1080                1085            
Leu Asn Val Leu Lys Pro Asn Asn Phe Ile Asp Arg Arg Lys Asp Ser 
    1090                1095                1100                
Thr Leu Ser Ile Asn Asn Ile Arg Ser Thr Ile Leu Leu Ala Asn Arg 
1105                1110                1115                1120
Leu Tyr Ser Gly Ile Lys Val Lys Ile Gln Arg Val Asn Asn Ser Ser 
                1125                1130                1135    
Thr Asn Asp Asn Leu Val Arg Lys Asn Asp Gln Val Tyr Ile Asn Phe 
            1140                1145                1150        
Val Ala Ser Lys Thr His Leu Phe Pro Leu Tyr Ala Asp Thr Ala Thr 
        1155                1160                1165            
Thr Asn Lys Glu Lys Thr Ile Lys Ile Ser Ser Ser Gly Asn Arg Phe 
    1170                1175                1180                
Asn Gln Val Val Val Met Asn Ser Val Gly Asn Cys Thr Met Asn Phe 
1185                1190                1195                1200
Lys Asn Asn Asn Gly Asn Asn Ile Gly Leu Leu Gly Phe Lys Ala Asp 
                1205                1210                1215    
Thr Val Val Ala Ser Thr Trp Tyr Tyr Thr His Met Arg Asp His Thr 
            1220                1225                1230        
Asn Ser Asn Gly Cys Phe Trp Asn Phe Ile Ser Glu Glu His Gly Trp 
        1235                1240                1245            
Gln Glu Lys 
    1250    

<210> 11
<211> 3843
<212> DNA
<213> Clostridium botulinum


<400> 11
atgccagttg taataaatag ttttaattat aatgaccctg ttaatgatga gacaatttta       60

tacatgcaga aaccatatga agaaagaagt agaaaatatt ataaagcttt tgagattatg      120

cctaatgttt ggataatgcc tgagagagat acaataggaa ctaagcctga tgagtttcag      180

gtgccggatt cattaaagaa cggaagtagt gcttattatg atcctaatta tttaaccact      240

gatgctgaaa aagatagata tttaaaaaca atgataaaat tatttaatag aattaatagt      300

aatcctacag ggaaagtttt gttagaagaa gtatcaaatg ctagaccata tttaggagat      360

gatgacacgc taattaatga attccttcca gttaatgtaa ctacaagtgt taatataaaa      420

ttttcaactg atgttgaaag ttcaataata tcgaatcttc ttgtattggg agcaggacct      480

gatatattta aagcttactg tacccccctt gtaaggttta ataagtcaga taaattaatt      540

gaaccaagta atcatggttt tggatcaatt aatatcttga cattttcacc tgagtatgaa      600

catattttta atgatattag tggagggaat cataatagta cagaatcatt tattgcagat      660

cctgcaattt cactagctca tgaattgata catgcactac atggattata cggggctaag      720

gcagttactc ataaagagtc tctagtagca gagcgaggac ctcttatgat agccgaaaag      780

cccataaggc tagaagaatt tttaactttt ggaggtgagg atttaaatat cattcctagt      840

gctatgaagg aaaaaatata taacgatctt ttagctaact atgaaaaaat agctactaga      900

cttagagaag ttaatacggc tcctcctgga tatgatatta atgaatataa agattatttt      960

caatggaagt atggactaga tagaaatgca gatggaagtt atactgtgaa tagaaataaa     1020

tttaatgaaa tttataaaaa attatatagc tttacagaga ttgacttagc aaataaattt     1080

aaagtaaaat gtagaaatac ttattttatt aaatatggat ttgtaaaagt tccaaatttg     1140

ttagatgatg atatttatac tgtatcagag gggtttaata taggtaattt agcagtaaac     1200

aatcgcggac aaaatataaa tttaaatcct aaaattattg attccattcc agataaaggt     1260

ttagtggaaa agattattaa attttgtaag agcattattc ctagaaaagg tacgaagcag     1320

tcaccgtcac tatgcattag agtaaataat agggagttat tttttgtagc ttcagaaagt     1380

agctataatg aaagtgatat taatacacct aaagaaattg acgatacaac aaatctaaat     1440

aataattata gaaataattt agatgaagtt attttagatt ataatagtga gacaatacct     1500

caaatatcaa atcgaacatt aaatacactt gtacaagaca atagttatgt gccaagatat     1560

gattctaatg gaacaagtga aatagaggaa tatgatgttg ttgactttaa tgtatttttc     1620

tatttacatg cacaaaaagt accagaaggt gaaaccaata taagtttaac ttcttcaatt     1680

gatacagcat tattagaaga atccaaagta tatacatttt tttcttcaga gtttatcgat     1740

actatcaata aacctgtaaa tgcagcacta tttatagatt ggataagcaa agtaataaga     1800

gattttacca ctgaagctac acaaaaaagt actgttgata agattgcaga catatcttta     1860

attgtaccct atgtaggtct tgctttgaat atagttattg aggcagaaaa aggaaatttt     1920

gaggaggcat ttgaattatt aggagcgggt attttattag aatttgtgcc agagcttaca     1980

attcctgtaa ttttagtgtt tacgataaaa tcctatatag attcatatga gaataaaaat     2040

aaagcaatta aagcaataaa taattcatta atcgaaagag aagcaaagtg gaaagaaata     2100

tatagttgga tagtatcaaa ttggcttact agaattaata cgcaatttaa taaaagaaaa     2160

gagcaaatgt atcaggcttt acaaaatcaa gtagatgcaa taaaaacagc aatagaatat     2220

aaatataata attatacttc agatgagaaa aatagacttg aatctaaata taatatcaat     2280

aatatagaag aagaattgaa taaaaaagtt tctttagcaa tgaaaaatat agaaagattt     2340

atgacagaaa gttctatatc ttatttaatg aaattaataa atgaagccga agttggtaaa     2400

ttaaaagaat atgataaaca tgttaagagc gatttattag actatattct ctaccataaa     2460

ttaatcttag gagagcagac aaaggaatta attgatttgg tgactagtac tttgaatagt     2520

agtattccat ttgaactttc ttcatatact aatgataaaa ttctaattat atattttaat     2580

agattatata aaaaaattaa agatagttct attttagata tgcgatatga aaataataaa     2640

tttatagata tctctggata tggttcaaat ataagcatta atggaaacgt atatatttat     2700

tcaacaaata gaaatcaatt tggaatatat agtggtaggc ttagtgaagt taatatagct     2760

caaaataatg atattatata caatagtaga tatcaaaatt ttagtattag tttctgggta     2820

accattccta aacactacag acctatgaat cgtaatcggg aatacactat aataaattgt     2880

atggggaata ataattcggg atggaaaata tcacttagaa ctattagaga ttgtgaaata     2940

atttggactt tacaagatac ttccggaaat aaggaaaaat taatttttag gtatgaagaa     3000

cttgctagta tatctgatta tataaataaa tggatttttg taactattac taataataga     3060

ttaggcaatt ctagaattta catcaatgga aatttaatag ttgaaaaatc aatttcgaat     3120

ttaggtgata ttcatgttag tgataatata ttatttaaaa ttgttggttg tgatgatgaa     3180

acgtatgttg gtataagata ttttaaagtt tttaatacgg aattagataa aacagaaatt     3240

gagactttat atagtaatga gccagatcca agtatcttaa aagactattg gggaaattat     3300

ttgctatata ataaaaaata ttatttattc aatttactaa gaaaagataa gtatattact     3360

cggaattcag gcattttaaa tattaatcaa caaagaggtg ttactggagg catatctgtt     3420

tttttgaact ataaattata tgaaggagta gaagttatta taagaaaaaa tgctcctata     3480

gatatatcta atacagataa ttttgttaga aaaaacgatc tagcatacat taatgtagta     3540

gatcatggtg tagaatatcg gttatatgct gatatatcaa ttacaaaatc agagaaaata     3600

ataaaattaa taagaacatc taatccaaac gatagcttag gtcaaattat agttatggat     3660

tcaataggaa ataattgcac aatgaatttt caaaacaatg atgggagcaa tataggatta     3720

ctaggttttc attcagatga tttggttgct agtagttggt attataacca tatacgaaga     3780

aacactagca gtaatggatg cttttggagt tttatttcta aagagcatgg ttggaaagaa     3840

taa                                                                   3843


<210> 12
<211> 1280
<212> PRT
<213> Clostridium botulinum


<400> 12
Met Pro Val Val Ile Asn Ser Phe Asn Tyr Asn Asp Pro Val Asn Asp 
1               5                   10                  15      
Glu Thr Ile Leu Tyr Met Gln Lys Pro Tyr Glu Glu Arg Ser Arg Lys 
            20                  25                  30          
Tyr Tyr Lys Ala Phe Glu Ile Met Pro Asn Val Trp Ile Met Pro Glu 
        35                  40                  45              
Arg Asp Thr Ile Gly Thr Lys Pro Asp Glu Phe Gln Val Pro Asp Ser 
    50                  55                  60                  
Leu Lys Asn Gly Ser Ser Ala Tyr Tyr Asp Pro Asn Tyr Leu Thr Thr 
65                  70                  75                  80  
Asp Ala Glu Lys Asp Arg Tyr Leu Lys Thr Met Ile Lys Leu Phe Asn 
                85                  90                  95      
Arg Ile Asn Ser Asn Pro Thr Gly Lys Val Leu Leu Glu Glu Val Ser 
            100                 105                 110         
Asn Ala Arg Pro Tyr Leu Gly Asp Asp Asp Thr Leu Ile Asn Glu Phe 
        115                 120                 125             
Leu Pro Val Asn Val Thr Thr Ser Val Asn Ile Lys Phe Ser Thr Asp 
    130                 135                 140                 
Val Glu Ser Ser Ile Ile Ser Asn Leu Leu Val Leu Gly Ala Gly Pro 
145                 150                 155                 160 
Asp Ile Phe Lys Ala Tyr Cys Thr Pro Leu Val Arg Phe Asn Lys Ser 
                165                 170                 175     
Asp Lys Leu Ile Glu Pro Ser Asn His Gly Phe Gly Ser Ile Asn Ile 
            180                 185                 190         
Leu Thr Phe Ser Pro Glu Tyr Glu His Ile Phe Asn Asp Ile Ser Gly 
        195                 200                 205             
Gly Asn His Asn Ser Thr Glu Ser Phe Ile Ala Asp Pro Ala Ile Ser 
    210                 215                 220                 
Leu Ala His Glu Leu Ile His Ala Leu His Gly Leu Tyr Gly Ala Lys 
225                 230                 235                 240 
Ala Val Thr His Lys Glu Ser Leu Val Ala Glu Arg Gly Pro Leu Met 
                245                 250                 255     
Ile Ala Glu Lys Pro Ile Arg Leu Glu Glu Phe Leu Thr Phe Gly Gly 
            260                 265                 270         
Glu Asp Leu Asn Ile Ile Pro Ser Ala Met Lys Glu Lys Ile Tyr Asn 
        275                 280                 285             
Asp Leu Leu Ala Asn Tyr Glu Lys Ile Ala Thr Arg Leu Arg Glu Val 
    290                 295                 300                 
Asn Thr Ala Pro Pro Gly Tyr Asp Ile Asn Glu Tyr Lys Asp Tyr Phe 
305                 310                 315                 320 
Gln Trp Lys Tyr Gly Leu Asp Arg Asn Ala Asp Gly Ser Tyr Thr Val 
                325                 330                 335     
Asn Arg Asn Lys Phe Asn Glu Ile Tyr Lys Lys Leu Tyr Ser Phe Thr 
            340                 345                 350         
Glu Ile Asp Leu Ala Asn Lys Phe Lys Val Lys Cys Arg Asn Thr Tyr 
        355                 360                 365             
Phe Ile Lys Tyr Gly Phe Val Lys Val Pro Asn Leu Leu Asp Asp Asp 
    370                 375                 380                 
Ile Tyr Thr Val Ser Glu Gly Phe Asn Ile Gly Asn Leu Ala Val Asn 
385                 390                 395                 400 
Asn Arg Gly Gln Asn Ile Asn Leu Asn Pro Lys Ile Ile Asp Ser Ile 
                405                 410                 415     
Pro Asp Lys Gly Leu Val Glu Lys Ile Ile Lys Phe Cys Lys Ser Ile 
            420                 425                 430         
Ile Pro Arg Lys Gly Thr Lys Gln Ser Pro Ser Leu Cys Ile Arg Val 
        435                 440                 445             
Asn Asn Arg Glu Leu Phe Phe Val Ala Ser Glu Ser Ser Tyr Asn Glu 
    450                 455                 460                 
Ser Asp Ile Asn Thr Pro Lys Glu Ile Asp Asp Thr Thr Asn Leu Asn 
465                 470                 475                 480 
Asn Asn Tyr Arg Asn Asn Leu Asp Glu Val Ile Leu Asp Tyr Asn Ser 
                485                 490                 495     
Glu Thr Ile Pro Gln Ile Ser Asn Arg Thr Leu Asn Thr Leu Val Gln 
            500                 505                 510         
Asp Asn Ser Tyr Val Pro Arg Tyr Asp Ser Asn Gly Thr Ser Glu Ile 
        515                 520                 525             
Glu Glu Tyr Asp Val Val Asp Phe Asn Val Phe Phe Tyr Leu His Ala 
    530                 535                 540                 
Gln Lys Val Pro Glu Gly Glu Thr Asn Ile Ser Leu Thr Ser Ser Ile 
545                 550                 555                 560 
Asp Thr Ala Leu Leu Glu Glu Ser Lys Val Tyr Thr Phe Phe Ser Ser 
                565                 570                 575     
Glu Phe Ile Asp Thr Ile Asn Lys Pro Val Asn Ala Ala Leu Phe Ile 
            580                 585                 590         
Asp Trp Ile Ser Lys Val Ile Arg Asp Phe Thr Thr Glu Ala Thr Gln 
        595                 600                 605             
Lys Ser Thr Val Asp Lys Ile Ala Asp Ile Ser Leu Ile Val Pro Tyr 
    610                 615                 620                 
Val Gly Leu Ala Leu Asn Ile Val Ile Glu Ala Glu Lys Gly Asn Phe 
625                 630                 635                 640 
Glu Glu Ala Phe Glu Leu Leu Gly Ala Gly Ile Leu Leu Glu Phe Val 
                645                 650                 655     
Pro Glu Leu Thr Ile Pro Val Ile Leu Val Phe Thr Ile Lys Ser Tyr 
            660                 665                 670         
Ile Asp Ser Tyr Glu Asn Lys Asn Lys Ala Ile Lys Ala Ile Asn Asn 
        675                 680                 685             
Ser Leu Ile Glu Arg Glu Ala Lys Trp Lys Glu Ile Tyr Ser Trp Ile 
    690                 695                 700                 
Val Ser Asn Trp Leu Thr Arg Ile Asn Thr Gln Phe Asn Lys Arg Lys 
705                 710                 715                 720 
Glu Gln Met Tyr Gln Ala Leu Gln Asn Gln Val Asp Ala Ile Lys Thr 
                725                 730                 735     
Ala Ile Glu Tyr Lys Tyr Asn Asn Tyr Thr Ser Asp Glu Lys Asn Arg 
            740                 745                 750         
Leu Glu Ser Lys Tyr Asn Ile Asn Asn Ile Glu Glu Glu Leu Asn Lys 
        755                 760                 765             
Lys Val Ser Leu Ala Met Lys Asn Ile Glu Arg Phe Met Thr Glu Ser 
    770                 775                 780                 
Ser Ile Ser Tyr Leu Met Lys Leu Ile Asn Glu Ala Glu Val Gly Lys 
785                 790                 795                 800 
Leu Lys Glu Tyr Asp Lys His Val Lys Ser Asp Leu Leu Asp Tyr Ile 
                805                 810                 815     
Leu Tyr His Lys Leu Ile Leu Gly Glu Gln Thr Lys Glu Leu Ile Asp 
            820                 825                 830         
Leu Val Thr Ser Thr Leu Asn Ser Ser Ile Pro Phe Glu Leu Ser Ser 
        835                 840                 845             
Tyr Thr Asn Asp Lys Ile Leu Ile Ile Tyr Phe Asn Arg Leu Tyr Lys 
    850                 855                 860                 
Lys Ile Lys Asp Ser Ser Ile Leu Asp Met Arg Tyr Glu Asn Asn Lys 
865                 870                 875                 880 
Phe Ile Asp Ile Ser Gly Tyr Gly Ser Asn Ile Ser Ile Asn Gly Asn 
                885                 890                 895     
Val Tyr Ile Tyr Ser Thr Asn Arg Asn Gln Phe Gly Ile Tyr Ser Gly 
            900                 905                 910         
Arg Leu Ser Glu Val Asn Ile Ala Gln Asn Asn Asp Ile Ile Tyr Asn 
        915                 920                 925             
Ser Arg Tyr Gln Asn Phe Ser Ile Ser Phe Trp Val Thr Ile Pro Lys 
    930                 935                 940                 
His Tyr Arg Pro Met Asn Arg Asn Arg Glu Tyr Thr Ile Ile Asn Cys 
945                 950                 955                 960 
Met Gly Asn Asn Asn Ser Gly Trp Lys Ile Ser Leu Arg Thr Ile Arg 
                965                 970                 975     
Asp Cys Glu Ile Ile Trp Thr Leu Gln Asp Thr Ser Gly Asn Lys Glu 
            980                 985                 990         
Lys Leu Ile Phe Arg Tyr Glu Glu Leu Ala Ser Ile Ser Asp Tyr Ile 
        995                 1000                1005            
Asn Lys Trp Ile Phe Val Thr Ile Thr Asn Asn Arg Leu Gly Asn Ser 
    1010                1015                1020                
Arg Ile Tyr Ile Asn Gly Asn Leu Ile Val Glu Lys Ser Ile Ser Asn 
1025                1030                1035                1040
Leu Gly Asp Ile His Val Ser Asp Asn Ile Leu Phe Lys Ile Val Gly 
                1045                1050                1055    
Cys Asp Asp Glu Thr Tyr Val Gly Ile Arg Tyr Phe Lys Val Phe Asn 
            1060                1065                1070        
Thr Glu Leu Asp Lys Thr Glu Ile Glu Thr Leu Tyr Ser Asn Glu Pro 
        1075                1080                1085            
Asp Pro Ser Ile Leu Lys Asp Tyr Trp Gly Asn Tyr Leu Leu Tyr Asn 
    1090                1095                1100                
Lys Lys Tyr Tyr Leu Phe Asn Leu Leu Arg Lys Asp Lys Tyr Ile Thr 
1105                1110                1115                1120
Arg Asn Ser Gly Ile Leu Asn Ile Asn Gln Gln Arg Gly Val Thr Gly 
                1125                1130                1135    
Gly Ile Ser Val Phe Leu Asn Tyr Lys Leu Tyr Glu Gly Val Glu Val 
            1140                1145                1150        
Ile Ile Arg Lys Asn Ala Pro Ile Asp Ile Ser Asn Thr Asp Asn Phe 
        1155                1160                1165            
Val Arg Lys Asn Asp Leu Ala Tyr Ile Asn Val Val Asp His Gly Val 
    1170                1175                1180                
Glu Tyr Arg Leu Tyr Ala Asp Ile Ser Ile Thr Lys Ser Glu Lys Ile 
1185                1190                1195                1200
Ile Lys Leu Ile Arg Thr Ser Asn Pro Asn Asp Ser Leu Gly Gln Ile 
                1205                1210                1215    
Ile Val Met Asp Ser Ile Gly Asn Asn Cys Thr Met Asn Phe Gln Asn 
            1220                1225                1230        
Asn Asp Gly Ser Asn Ile Gly Leu Leu Gly Phe His Ser Asp Asp Leu 
        1235                1240                1245            
Val Ala Ser Ser Trp Tyr Tyr Asn His Ile Arg Arg Asn Thr Ser Ser 
    1250                1255                1260                
Asn Gly Cys Phe Trp Ser Phe Ile Ser Lys Glu His Gly Trp Lys Glu 
1265                1270                1275                1280



<210> 13
<211> 3894
<212> DNA
<213> Clostridium botulinum

<223> "n is a, c, g, or t"

<220> 
<223> n is a, c, g, or t

<400> 13
atgccagtta atataaaaan ctttaattat aatgacccta ttaataatga tgacattatt       60

atgatggaac cattcaatga cccagggcca ggaacatatt ataaagcttt taggattata      120

gatcgtattt ggatagtacc agaaaggttt acttatggat ttcaacctga ccaatttaat      180

gccagtacag gagtttttag taaagatgtc tacgaatatt acgatccaac ttatttaaaa      240

accgatgctg aaaaagataa atttttaaaa acaatgatta aattatttaa tagaattaat      300

tcaaaaccat caggacagag attactggat atgatagtag atgctatacc ttatcttgga      360

aatgcatcta caccgcccga caaatttgca gcaaatgttg caaatgtatc tattaataaa      420

aaaattatcc aacctggagc tgaagatcaa ataaaaggtt taatgacaaa tttaataata      480

tttggaccag gaccagttct aagtgataat tttactgata gtatgattat gaatggccat      540

tccccaatat cagaaggatt tggtgcaaga atgatgataa gattttgtcc tagttgttta      600

aatgtattta ataatgttca ggaaaataaa gatacatcta tatttagtag acgcgcgtat      660

tttgcagatc cagctctaac gttaatgcat gaacttatac atgtgttaca tggattatat      720

ggaattaaga taagtaattt accaattact ccaaatacaa aagaattttt catgcaacat      780

agcgatcctg tacaagcaga agaactatat acattcggag gacatgatcc tagtgttata      840

agtccttcta cggatatgaa tatttataat aaagcgttac aaaattttca agatatagct      900

aataggctta atattgtttc aagtgcccaa gggagtggaa ttgatatttc cttatataaa      960

caaatatata aaaataaata tgattttgtt gaagatccta atggaaaata tagtgtagat     1020

aaggataagt ttgataaatt atataaggcc ttaatgtttg gctttactga aactaatcta     1080

gctggtgaat atggaataaa aactaggtat tcttatttta gtgaatattt gccaccgata     1140

aaaactgaaa aattgttaga caatacaatt tatactcaaa atgaaggctt taacatagct     1200

agtaaaaatc tcaaaacgga atttaatggt cagaataagg cggtaaataa agaggcttat     1260

gaagaaatca gcctagaaca tctcgttata tatagaatag caatgtgcaa gcctgtaatg     1320

tacaaaaata ccggtaaatc tgaacagtgt attattgtta ataatgagga tttatttttc     1380

atagctaata aagatagttt ttcaaaagat ttagctaaag cagaaactat agcatataat     1440

acacaaaata atactataga aaataatttt tctatagatc agttgatttt agataatgat     1500

ttaagcagtg gcatagactt accaaatgaa aacacagaac catttacaaa ttttgacgac     1560

atagatatcc ctgtgtatat taaacaatct gctttaaaaa aaatttttgt ggatggagat     1620

agcctttttg aatatttaca tgctcaaaca tttccttcta atatagaaaa tctacaacta     1680

acgaattcat taaatgatgc tttaagaaat aataataaag tctatacttt tttttctaca     1740

aaccttgttg aaaaagctaa tacagttgta ggtgcttcac tttttgtaaa ctgggtaaaa     1800

ggagtaatag atgattttac atctgaatcc acacaaaaaa gtactataga taaagtttca     1860

gatgtatcca taattattcc ctatatagga cctgctttga atgtaggaaa tgaaacagct     1920

aaagaaaatt ttaaaaatgc ttttgaaata ggtggagccg ctatcttaat ggagtttatt     1980

ccagaactta ttgtacctat agttggattt tttacattag aatcatatgt aggaaataaa     2040

gggcatatta ttatgacgat atccaatgct ttaaagaaaa gggatcaaaa atggacagat     2100

atgtatggtt tgatagtatc gcagtggctc tcaacggtta atactcaatt ttatacaata     2160

aaagaaagaa tgtacaatgc tttaaataat caatcacaag caatagaaaa aataatagaa     2220

gatcaatata atagatatag tgaagaagat aaaatgaata ttaacattga ttttaatgat     2280

atagatttta aacttaatca aagtataaat ttagcaataa acaatataga tgattttata     2340

aaccaatgtt ctatatcata tctaatgaat agaatgattc cattagctgt aaaaaagtta     2400

aaagactttg atgataatct taagagagat ttattggagt atatagatac aaatgaacta     2460

tatttacttg atgaagtaaa tattctaaaa tcaaaagtaa atagacacct aaaagacagt     2520

ataccatttg atctttcact atataccaag gacacaattt taatacaagt ttttaataat     2580

tatattagta atattagtag taatgctatt ttaagtttaa gttatagagg tgggcgttta     2640

atagattcat ctggatatgg tgcaactatg aatgtaggtt cagatgttat ctttaatgat     2700

ataggaaatg gtcaatttaa attaaataat tctgaaaata gtaatattac ggcacatcaa     2760

agtaaattcg ttgtatatga tagtatgttt gataatttta gcattaactt ttgggtaagg     2820

actcctaaat ataataataa tgatatacaa acttatcttc aaaatgagta tacaataatt     2880

agttgtataa aaaatgactc aggatggaaa gtatctatta agggaaatag aataatatgg     2940

acattaatag atgttaatgc aaaatctaaa tcaatatttt tcgaatatag tataaaagat     3000

aatatatcag attatataaa taaatggttt tccataacta ttactaatga tagattaggt     3060

aacgcaaata tttatataaa tggaagtttg aaaaaaagtg aaaaaatttt aaacttagat     3120

agaattaatt ctagtaatga tatagacttc aaattaatta attgtacaga tactactaaa     3180

tttgtttgga ttaaggattt taatattttt ggtagagaat taaatgctac agaagtatct     3240

tcactatatt ggattcaatc atctacaaat actttaaaag atttttgggg gaatccttta     3300

agatacgata cacaatacta tctgtttaat caaggtatgc aaaatatcta tataaagtat     3360

tttagtaaag cttctatggg ggaaactgca ccacgtacaa actttaataa tgcagcaata     3420

aattatcaaa atttatatct tggtttacga tttattataa aaaaagcatc aaattctcgg     3480

aatataaata atgataatat agtcagagaa ggagattata tatatcttaa tattgataat     3540

atttctgatg aatcttacag agtatatgtt ttggtgaatt ctaaagaaat tcaaactcaa     3600

ttatttttag cacccataaa tgatgatcct acgttctatg atgtactaca aataaaaaaa     3660

tattatgaaa aaacaacata taattgtcag atactttgcg aaaaagatac taaaacattt     3720

gggctgtttg gaattggtaa atttgttaaa gattatggat atgtttggga tacctatgat     3780

aattattttt gcataagtca gtggtatctc agaagaatat ctgaaaatat aaataaatta     3840

aggttgggat gtaattggca attcattccc gtggatgaag gatggacaga ataa           3894


<210> 14
<211> 1297
<212> PRT
<213> Clostridium botulinum

<223> "Xaa can be any naturally occurring amino acid"

<220> 
<223> Xaa can be any naturally occurring amino acid

<400> 14
Met Pro Val Asn Ile Lys Xaa Phe Asn Tyr Asn Asp Pro Ile Asn Asn 
1               5                   10                  15      
Asp Asp Ile Ile Met Met Glu Pro Phe Asn Asp Pro Gly Pro Gly Thr 
            20                  25                  30          
Tyr Tyr Lys Ala Phe Arg Ile Ile Asp Arg Ile Trp Ile Val Pro Glu 
        35                  40                  45              
Arg Phe Thr Tyr Gly Phe Gln Pro Asp Gln Phe Asn Ala Ser Thr Gly 
    50                  55                  60                  
Val Phe Ser Lys Asp Val Tyr Glu Tyr Tyr Asp Pro Thr Tyr Leu Lys 
65                  70                  75                  80  
Thr Asp Ala Glu Lys Asp Lys Phe Leu Lys Thr Met Ile Lys Leu Phe 
                85                  90                  95      
Asn Arg Ile Asn Ser Lys Pro Ser Gly Gln Arg Leu Leu Asp Met Ile 
            100                 105                 110         
Val Asp Ala Ile Pro Tyr Leu Gly Asn Ala Ser Thr Pro Pro Asp Lys 
        115                 120                 125             
Phe Ala Ala Asn Val Ala Asn Val Ser Ile Asn Lys Lys Ile Ile Gln 
    130                 135                 140                 
Pro Gly Ala Glu Asp Gln Ile Lys Gly Leu Met Thr Asn Leu Ile Ile 
145                 150                 155                 160 
Phe Gly Pro Gly Pro Val Leu Ser Asp Asn Phe Thr Asp Ser Met Ile 
                165                 170                 175     
Met Asn Gly His Ser Pro Ile Ser Glu Gly Phe Gly Ala Arg Met Met 
            180                 185                 190         
Ile Arg Phe Cys Pro Ser Cys Leu Asn Val Phe Asn Asn Val Gln Glu 
        195                 200                 205             
Asn Lys Asp Thr Ser Ile Phe Ser Arg Arg Ala Tyr Phe Ala Asp Pro 
    210                 215                 220                 
Ala Leu Thr Leu Met His Glu Leu Ile His Val Leu His Gly Leu Tyr 
225                 230                 235                 240 
Gly Ile Lys Ile Ser Asn Leu Pro Ile Thr Pro Asn Thr Lys Glu Phe 
                245                 250                 255     
Phe Met Gln His Ser Asp Pro Val Gln Ala Glu Glu Leu Tyr Thr Phe 
            260                 265                 270         
Gly Gly His Asp Pro Ser Val Ile Ser Pro Ser Thr Asp Met Asn Ile 
        275                 280                 285             
Tyr Asn Lys Ala Leu Gln Asn Phe Gln Asp Ile Ala Asn Arg Leu Asn 
    290                 295                 300                 
Ile Val Ser Ser Ala Gln Gly Ser Gly Ile Asp Ile Ser Leu Tyr Lys 
305                 310                 315                 320 
Gln Ile Tyr Lys Asn Lys Tyr Asp Phe Val Glu Asp Pro Asn Gly Lys 
                325                 330                 335     
Tyr Ser Val Asp Lys Asp Lys Phe Asp Lys Leu Tyr Lys Ala Leu Met 
            340                 345                 350         
Phe Gly Phe Thr Glu Thr Asn Leu Ala Gly Glu Tyr Gly Ile Lys Thr 
        355                 360                 365             
Arg Tyr Ser Tyr Phe Ser Glu Tyr Leu Pro Pro Ile Lys Thr Glu Lys 
    370                 375                 380                 
Leu Leu Asp Asn Thr Ile Tyr Thr Gln Asn Glu Gly Phe Asn Ile Ala 
385                 390                 395                 400 
Ser Lys Asn Leu Lys Thr Glu Phe Asn Gly Gln Asn Lys Ala Val Asn 
                405                 410                 415     
Lys Glu Ala Tyr Glu Glu Ile Ser Leu Glu His Leu Val Ile Tyr Arg 
            420                 425                 430         
Ile Ala Met Cys Lys Pro Val Met Tyr Lys Asn Thr Gly Lys Ser Glu 
        435                 440                 445             
Gln Cys Ile Ile Val Asn Asn Glu Asp Leu Phe Phe Ile Ala Asn Lys 
    450                 455                 460                 
Asp Ser Phe Ser Lys Asp Leu Ala Lys Ala Glu Thr Ile Ala Tyr Asn 
465                 470                 475                 480 
Thr Gln Asn Asn Thr Ile Glu Asn Asn Phe Ser Ile Asp Gln Leu Ile 
                485                 490                 495     
Leu Asp Asn Asp Leu Ser Ser Gly Ile Asp Leu Pro Asn Glu Asn Thr 
            500                 505                 510         
Glu Pro Phe Thr Asn Phe Asp Asp Ile Asp Ile Pro Val Tyr Ile Lys 
        515                 520                 525             
Gln Ser Ala Leu Lys Lys Ile Phe Val Asp Gly Asp Ser Leu Phe Glu 
    530                 535                 540                 
Tyr Leu His Ala Gln Thr Phe Pro Ser Asn Ile Glu Asn Leu Gln Leu 
545                 550                 555                 560 
Thr Asn Ser Leu Asn Asp Ala Leu Arg Asn Asn Asn Lys Val Tyr Thr 
                565                 570                 575     
Phe Phe Ser Thr Asn Leu Val Glu Lys Ala Asn Thr Val Val Gly Ala 
            580                 585                 590         
Ser Leu Phe Val Asn Trp Val Lys Gly Val Ile Asp Asp Phe Thr Ser 
        595                 600                 605             
Glu Ser Thr Gln Lys Ser Thr Ile Asp Lys Val Ser Asp Val Ser Ile 
    610                 615                 620                 
Ile Ile Pro Tyr Ile Gly Pro Ala Leu Asn Val Gly Asn Glu Thr Ala 
625                 630                 635                 640 
Lys Glu Asn Phe Lys Asn Ala Phe Glu Ile Gly Gly Ala Ala Ile Leu 
                645                 650                 655     
Met Glu Phe Ile Pro Glu Leu Ile Val Pro Ile Val Gly Phe Phe Thr 
            660                 665                 670         
Leu Glu Ser Tyr Val Gly Asn Lys Gly His Ile Ile Met Thr Ile Ser 
        675                 680                 685             
Asn Ala Leu Lys Lys Arg Asp Gln Lys Trp Thr Asp Met Tyr Gly Leu 
    690                 695                 700                 
Ile Val Ser Gln Trp Leu Ser Thr Val Asn Thr Gln Phe Tyr Thr Ile 
705                 710                 715                 720 
Lys Glu Arg Met Tyr Asn Ala Leu Asn Asn Gln Ser Gln Ala Ile Glu 
                725                 730                 735     
Lys Ile Ile Glu Asp Gln Tyr Asn Arg Tyr Ser Glu Glu Asp Lys Met 
            740                 745                 750         
Asn Ile Asn Ile Asp Phe Asn Asp Ile Asp Phe Lys Leu Asn Gln Ser 
        755                 760                 765             
Ile Asn Leu Ala Ile Asn Asn Ile Asp Asp Phe Ile Asn Gln Cys Ser 
    770                 775                 780                 
Ile Ser Tyr Leu Met Asn Arg Met Ile Pro Leu Ala Val Lys Lys Leu 
785                 790                 795                 800 
Lys Asp Phe Asp Asp Asn Leu Lys Arg Asp Leu Leu Glu Tyr Ile Asp 
                805                 810                 815     
Thr Asn Glu Leu Tyr Leu Leu Asp Glu Val Asn Ile Leu Lys Ser Lys 
            820                 825                 830         
Val Asn Arg His Leu Lys Asp Ser Ile Pro Phe Asp Leu Ser Leu Tyr 
        835                 840                 845             
Thr Lys Asp Thr Ile Leu Ile Gln Val Phe Asn Asn Tyr Ile Ser Asn 
    850                 855                 860                 
Ile Ser Ser Asn Ala Ile Leu Ser Leu Ser Tyr Arg Gly Gly Arg Leu 
865                 870                 875                 880 
Ile Asp Ser Ser Gly Tyr Gly Ala Thr Met Asn Val Gly Ser Asp Val 
                885                 890                 895     
Ile Phe Asn Asp Ile Gly Asn Gly Gln Phe Lys Leu Asn Asn Ser Glu 
            900                 905                 910         
Asn Ser Asn Ile Thr Ala His Gln Ser Lys Phe Val Val Tyr Asp Ser 
        915                 920                 925             
Met Phe Asp Asn Phe Ser Ile Asn Phe Trp Val Arg Thr Pro Lys Tyr 
    930                 935                 940                 
Asn Asn Asn Asp Ile Gln Thr Tyr Leu Gln Asn Glu Tyr Thr Ile Ile 
945                 950                 955                 960 
Ser Cys Ile Lys Asn Asp Ser Gly Trp Lys Val Ser Ile Lys Gly Asn 
                965                 970                 975     
Arg Ile Ile Trp Thr Leu Ile Asp Val Asn Ala Lys Ser Lys Ser Ile 
            980                 985                 990         
Phe Phe Glu Tyr Ser Ile Lys Asp Asn Ile Ser Asp Tyr Ile Asn Lys 
        995                 1000                1005            
Trp Phe Ser Ile Thr Ile Thr Asn Asp Arg Leu Gly Asn Ala Asn Ile 
    1010                1015                1020                
Tyr Ile Asn Gly Ser Leu Lys Lys Ser Glu Lys Ile Leu Asn Leu Asp 
1025                1030                1035                1040
Arg Ile Asn Ser Ser Asn Asp Ile Asp Phe Lys Leu Ile Asn Cys Thr 
                1045                1050                1055    
Asp Thr Thr Lys Phe Val Trp Ile Lys Asp Phe Asn Ile Phe Gly Arg 
            1060                1065                1070        
Glu Leu Asn Ala Thr Glu Val Ser Ser Leu Tyr Trp Ile Gln Ser Ser 
        1075                1080                1085            
Thr Asn Thr Leu Lys Asp Phe Trp Gly Asn Pro Leu Arg Tyr Asp Thr 
    1090                1095                1100                
Gln Tyr Tyr Leu Phe Asn Gln Gly Met Gln Asn Ile Tyr Ile Lys Tyr 
1105                1110                1115                1120
Phe Ser Lys Ala Ser Met Gly Glu Thr Ala Pro Arg Thr Asn Phe Asn 
                1125                1130                1135    
Asn Ala Ala Ile Asn Tyr Gln Asn Leu Tyr Leu Gly Leu Arg Phe Ile 
            1140                1145                1150        
Ile Lys Lys Ala Ser Asn Ser Arg Asn Ile Asn Asn Asp Asn Ile Val 
        1155                1160                1165            
Arg Glu Gly Asp Tyr Ile Tyr Leu Asn Ile Asp Asn Ile Ser Asp Glu 
    1170                1175                1180                
Ser Tyr Arg Val Tyr Val Leu Val Asn Ser Lys Glu Ile Gln Thr Gln 
1185                1190                1195                1200
Leu Phe Leu Ala Pro Ile Asn Asp Asp Pro Thr Phe Tyr Asp Val Leu 
                1205                1210                1215    
Gln Ile Lys Lys Tyr Tyr Glu Lys Thr Thr Tyr Asn Cys Gln Ile Leu 
            1220                1225                1230        
Cys Glu Lys Asp Thr Lys Thr Phe Gly Leu Phe Gly Ile Gly Lys Phe 
        1235                1240                1245            
Val Lys Asp Tyr Gly Tyr Val Trp Asp Thr Tyr Asp Asn Tyr Phe Cys 
    1250                1255                1260                
Ile Ser Gln Trp Tyr Leu Arg Arg Ile Ser Glu Asn Ile Asn Lys Leu 
1265                1270                1275                1280
Arg Leu Gly Cys Asn Trp Gln Phe Ile Pro Val Asp Glu Gly Trp Thr 
                1285                1290                1295    
Glu 
    

