                         SEQUENCE LISTING

<110>  bluebird bio, Inc.
       Jarjour, Jordan
       Havens, Kyle
       Krostag, Anne-Rachel
 
<120>  CBLB ENDONUCLEASE VARIANTS, COMPOSITIONS, AND METHODS OF USE

<130>  BLBD-087/04WO

<160>  84    

<170>  PatentIn version 3.5

<210>  1
<211>  303
<212>  PRT
<213>  Ophiostoma novo-ulmi

<400>  1

Met Ala Tyr Met Ser Arg Arg Glu Ser Ile Asn Pro Trp Ile Leu Thr 
1               5                   10                  15      


Gly Phe Ala Asp Ala Glu Gly Ser Phe Leu Leu Arg Ile Arg Asn Asn 
            20                  25                  30          


Asn Lys Ser Ser Val Gly Tyr Ser Thr Glu Leu Gly Phe Gln Ile Thr 
        35                  40                  45              


Leu His Asn Lys Asp Lys Ser Ile Leu Glu Asn Ile Gln Ser Thr Trp 
    50                  55                  60                  


Lys Val Gly Val Ile Ala Asn Ser Gly Asp Asn Ala Val Ser Leu Lys 
65                  70                  75                  80  


Val Thr Arg Phe Glu Asp Leu Lys Val Ile Ile Asp His Phe Glu Lys 
                85                  90                  95      


Tyr Pro Leu Ile Thr Gln Lys Leu Gly Asp Tyr Met Leu Phe Lys Gln 
            100                 105                 110         


Ala Phe Cys Val Met Glu Asn Lys Glu His Leu Lys Ile Asn Gly Ile 
        115                 120                 125             


Lys Glu Leu Val Arg Ile Lys Ala Lys Leu Asn Trp Gly Leu Thr Asp 
    130                 135                 140                 


Glu Leu Lys Lys Ala Phe Pro Glu Ile Ile Ser Lys Glu Arg Ser Leu 
145                 150                 155                 160 


Ile Asn Lys Asn Ile Pro Asn Phe Lys Trp Leu Ala Gly Phe Thr Ser 
                165                 170                 175     


Gly Glu Gly Cys Phe Phe Val Asn Leu Ile Lys Ser Lys Ser Lys Leu 
            180                 185                 190         


Gly Val Gln Val Gln Leu Val Phe Ser Ile Thr Gln His Ile Lys Asp 
        195                 200                 205             


Lys Asn Leu Met Asn Ser Leu Ile Thr Tyr Leu Gly Cys Gly Tyr Ile 
    210                 215                 220                 


Lys Glu Lys Asn Lys Ser Glu Phe Ser Trp Leu Asp Phe Val Val Thr 
225                 230                 235                 240 


Lys Phe Ser Asp Ile Asn Asp Lys Ile Ile Pro Val Phe Gln Glu Asn 
                245                 250                 255     


Thr Leu Ile Gly Val Lys Leu Glu Asp Phe Glu Asp Trp Cys Lys Val 
            260                 265                 270         


Ala Lys Leu Ile Glu Glu Lys Lys His Leu Thr Glu Ser Gly Leu Asp 
        275                 280                 285             


Glu Ile Lys Lys Ile Lys Leu Asn Met Asn Lys Gly Arg Val Phe 
    290                 295                 300             


<210>  2
<211>  303
<212>  PRT
<213>  Ophiostoma novo-ulmi

<400>  2

Met Ala Tyr Met Ser Arg Arg Glu Ser Ile Asn Pro Trp Ile Leu Thr 
1               5                   10                  15      


Gly Phe Ala Asp Ala Glu Gly Ser Phe Leu Leu Arg Ile Arg Asn Asn 
            20                  25                  30          


Asn Lys Ser Ser Val Gly Tyr Ser Thr Glu Leu Gly Phe Gln Ile Thr 
        35                  40                  45              


Leu His Asn Lys Asp Lys Ser Ile Leu Glu Asn Ile Gln Ser Thr Trp 
    50                  55                  60                  


Lys Val Gly Val Ile Ala Asn Ser Gly Asp Asn Ala Val Ser Leu Lys 
65                  70                  75                  80  


Val Thr Arg Phe Glu Asp Leu Lys Val Ile Ile Asp His Phe Glu Lys 
                85                  90                  95      


Tyr Pro Leu Ile Thr Gln Lys Leu Gly Asp Tyr Lys Leu Phe Lys Gln 
            100                 105                 110         


Ala Phe Ser Val Met Glu Asn Lys Glu His Leu Lys Glu Asn Gly Ile 
        115                 120                 125             


Lys Glu Leu Val Arg Ile Lys Ala Lys Leu Asn Trp Gly Leu Thr Asp 
    130                 135                 140                 


Glu Leu Lys Lys Ala Phe Pro Glu Asn Ile Ser Lys Glu Arg Ser Leu 
145                 150                 155                 160 


Ile Asn Lys Asn Ile Pro Asn Phe Lys Trp Leu Ala Gly Phe Thr Ser 
                165                 170                 175     


Gly Glu Gly Cys Phe Phe Val Asn Leu Ile Lys Ser Lys Ser Lys Leu 
            180                 185                 190         


Gly Val Gln Val Gln Leu Val Phe Ser Ile Thr Gln His Ile Lys Asp 
        195                 200                 205             


Lys Asn Leu Met Asn Ser Leu Ile Thr Tyr Leu Gly Cys Gly Tyr Ile 
    210                 215                 220                 


Lys Glu Lys Asn Lys Ser Glu Phe Ser Trp Leu Asp Phe Val Val Thr 
225                 230                 235                 240 


Lys Phe Ser Asp Ile Asn Asp Lys Ile Ile Pro Val Phe Gln Glu Asn 
                245                 250                 255     


Thr Leu Ile Gly Val Lys Leu Glu Asp Phe Glu Asp Trp Cys Lys Val 
            260                 265                 270         


Ala Lys Leu Ile Glu Glu Lys Lys His Leu Thr Glu Ser Gly Leu Asp 
        275                 280                 285             


Glu Ile Lys Lys Ile Lys Leu Asn Met Asn Lys Gly Arg Val Phe 
    290                 295                 300             


<210>  3
<211>  306
<212>  PRT
<213>  Ophiostoma novo-ulmi


<220>
<221>  MOD_RES
<222>  (1)..(3)
<223>  Any amino acid or absent

<220>
<221>  MOD_RES
<222>  (304)..(306)
<223>  Any amino acid or absent

<400>  3

Xaa Xaa Xaa Met Ser Arg Arg Glu Ser Ile Asn Pro Trp Ile Leu Thr 
1               5                   10                  15      


Gly Phe Ala Asp Ala Glu Gly Ser Phe Leu Leu Arg Ile Arg Asn Asn 
            20                  25                  30          


Asn Lys Ser Ser Val Gly Tyr Ser Thr Glu Leu Gly Phe Gln Ile Thr 
        35                  40                  45              


Leu His Asn Lys Asp Lys Ser Ile Leu Glu Asn Ile Gln Ser Thr Trp 
    50                  55                  60                  


Lys Val Gly Val Ile Ala Asn Ser Gly Asp Asn Ala Val Ser Leu Lys 
65                  70                  75                  80  


Val Thr Arg Phe Glu Asp Leu Lys Val Ile Ile Asp His Phe Glu Lys 
                85                  90                  95      


Tyr Pro Leu Ile Thr Gln Lys Leu Gly Asp Tyr Lys Leu Phe Lys Gln 
            100                 105                 110         


Ala Phe Ser Val Met Glu Asn Lys Glu His Leu Lys Glu Asn Gly Ile 
        115                 120                 125             


Lys Glu Leu Val Arg Ile Lys Ala Lys Leu Asn Trp Gly Leu Thr Asp 
    130                 135                 140                 


Glu Leu Lys Lys Ala Phe Pro Glu Asn Ile Ser Lys Glu Arg Ser Leu 
145                 150                 155                 160 


Ile Asn Lys Asn Ile Pro Asn Phe Lys Trp Leu Ala Gly Phe Thr Ser 
                165                 170                 175     


Gly Glu Gly Cys Phe Phe Val Asn Leu Ile Lys Ser Lys Ser Lys Leu 
            180                 185                 190         


Gly Val Gln Val Gln Leu Val Phe Ser Ile Thr Gln His Ile Lys Asp 
        195                 200                 205             


Lys Asn Leu Met Asn Ser Leu Ile Thr Tyr Leu Gly Cys Gly Tyr Ile 
    210                 215                 220                 


Lys Glu Lys Asn Lys Ser Glu Phe Ser Trp Leu Asp Phe Val Val Thr 
225                 230                 235                 240 


Lys Phe Ser Asp Ile Asn Asp Lys Ile Ile Pro Val Phe Gln Glu Asn 
                245                 250                 255     


Thr Leu Ile Gly Val Lys Leu Glu Asp Phe Glu Asp Trp Cys Lys Val 
            260                 265                 270         


Ala Lys Leu Ile Glu Glu Lys Lys His Leu Thr Glu Ser Gly Leu Asp 
        275                 280                 285             


Glu Ile Lys Lys Ile Lys Leu Asn Met Asn Lys Gly Arg Val Phe Xaa 
    290                 295                 300                 


Xaa Xaa 
305     


<210>  4
<211>  306
<212>  PRT
<213>  Ophiostoma novo-ulmi


<220>
<221>  MOD_RES
<222>  (1)..(4)
<223>  Any amino acid or absent

<220>
<221>  MOD_RES
<222>  (302)..(306)
<223>  Any amino acid or absent

<400>  4

Xaa Xaa Xaa Xaa Ser Arg Arg Glu Ser Ile Asn Pro Trp Ile Leu Thr 
1               5                   10                  15      


Gly Phe Ala Asp Ala Glu Gly Ser Phe Leu Leu Arg Ile Arg Asn Asn 
            20                  25                  30          


Asn Lys Ser Ser Val Gly Tyr Ser Thr Glu Leu Gly Phe Gln Ile Thr 
        35                  40                  45              


Leu His Asn Lys Asp Lys Ser Ile Leu Glu Asn Ile Gln Ser Thr Trp 
    50                  55                  60                  


Lys Val Gly Val Ile Ala Asn Ser Gly Asp Asn Ala Val Ser Leu Lys 
65                  70                  75                  80  


Val Thr Arg Phe Glu Asp Leu Lys Val Ile Ile Asp His Phe Glu Lys 
                85                  90                  95      


Tyr Pro Leu Ile Thr Gln Lys Leu Gly Asp Tyr Lys Leu Phe Lys Gln 
            100                 105                 110         


Ala Phe Ser Val Met Glu Asn Lys Glu His Leu Lys Glu Asn Gly Ile 
        115                 120                 125             


Lys Glu Leu Val Arg Ile Lys Ala Lys Leu Asn Trp Gly Leu Thr Asp 
    130                 135                 140                 


Glu Leu Lys Lys Ala Phe Pro Glu Asn Ile Ser Lys Glu Arg Ser Leu 
145                 150                 155                 160 


Ile Asn Lys Asn Ile Pro Asn Phe Lys Trp Leu Ala Gly Phe Thr Ser 
                165                 170                 175     


Gly Glu Gly Cys Phe Phe Val Asn Leu Ile Lys Ser Lys Ser Lys Leu 
            180                 185                 190         


Gly Val Gln Val Gln Leu Val Phe Ser Ile Thr Gln His Ile Lys Asp 
        195                 200                 205             


Lys Asn Leu Met Asn Ser Leu Ile Thr Tyr Leu Gly Cys Gly Tyr Ile 
    210                 215                 220                 


Lys Glu Lys Asn Lys Ser Glu Phe Ser Trp Leu Asp Phe Val Val Thr 
225                 230                 235                 240 


Lys Phe Ser Asp Ile Asn Asp Lys Ile Ile Pro Val Phe Gln Glu Asn 
                245                 250                 255     


Thr Leu Ile Gly Val Lys Leu Glu Asp Phe Glu Asp Trp Cys Lys Val 
            260                 265                 270         


Ala Lys Leu Ile Glu Glu Lys Lys His Leu Thr Glu Ser Gly Leu Asp 
        275                 280                 285             


Glu Ile Lys Lys Ile Lys Leu Asn Met Asn Lys Gly Arg Xaa Xaa Xaa 
    290                 295                 300                 


Xaa Xaa 
305     


<210>  5
<211>  306
<212>  PRT
<213>  Ophiostoma novo-ulmi


<220>
<221>  MOD_RES
<222>  (1)..(8)
<223>  Any amino acid or absent

<220>
<221>  MOD_RES
<222>  (302)..(306)
<223>  Any amino acid or absent

<400>  5

Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Ser Ile Asn Pro Trp Ile Leu Thr 
1               5                   10                  15      


Gly Phe Ala Asp Ala Glu Gly Ser Phe Leu Leu Arg Ile Arg Asn Asn 
            20                  25                  30          


Asn Lys Ser Ser Val Gly Tyr Ser Thr Glu Leu Gly Phe Gln Ile Thr 
        35                  40                  45              


Leu His Asn Lys Asp Lys Ser Ile Leu Glu Asn Ile Gln Ser Thr Trp 
    50                  55                  60                  


Lys Val Gly Val Ile Ala Asn Ser Gly Asp Asn Ala Val Ser Leu Lys 
65                  70                  75                  80  


Val Thr Arg Phe Glu Asp Leu Lys Val Ile Ile Asp His Phe Glu Lys 
                85                  90                  95      


Tyr Pro Leu Ile Thr Gln Lys Leu Gly Asp Tyr Lys Leu Phe Lys Gln 
            100                 105                 110         


Ala Phe Ser Val Met Glu Asn Lys Glu His Leu Lys Glu Asn Gly Ile 
        115                 120                 125             


Lys Glu Leu Val Arg Ile Lys Ala Lys Leu Asn Trp Gly Leu Thr Asp 
    130                 135                 140                 


Glu Leu Lys Lys Ala Phe Pro Glu Asn Ile Ser Lys Glu Arg Ser Leu 
145                 150                 155                 160 


Ile Asn Lys Asn Ile Pro Asn Phe Lys Trp Leu Ala Gly Phe Thr Ser 
                165                 170                 175     


Gly Glu Gly Cys Phe Phe Val Asn Leu Ile Lys Ser Lys Ser Lys Leu 
            180                 185                 190         


Gly Val Gln Val Gln Leu Val Phe Ser Ile Thr Gln His Ile Lys Asp 
        195                 200                 205             


Lys Asn Leu Met Asn Ser Leu Ile Thr Tyr Leu Gly Cys Gly Tyr Ile 
    210                 215                 220                 


Lys Glu Lys Asn Lys Ser Glu Phe Ser Trp Leu Asp Phe Val Val Thr 
225                 230                 235                 240 


Lys Phe Ser Asp Ile Asn Asp Lys Ile Ile Pro Val Phe Gln Glu Asn 
                245                 250                 255     


Thr Leu Ile Gly Val Lys Leu Glu Asp Phe Glu Asp Trp Cys Lys Val 
            260                 265                 270         


Ala Lys Leu Ile Glu Glu Lys Lys His Leu Thr Glu Ser Gly Leu Asp 
        275                 280                 285             


Glu Ile Lys Lys Ile Lys Leu Asn Met Asn Lys Gly Arg Xaa Xaa Xaa 
    290                 295                 300                 


Xaa Xaa 
305     


<210>  6
<211>  306
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized I-OnuI variant CBLB.E3


<220>
<221>  MOD_RES
<222>  (1)..(4)
<223>  Any amino acid or absent

<220>
<221>  MOD_RES
<222>  (302)..(306)
<223>  Any amino acid or absent

<400>  6

Xaa Xaa Xaa Xaa Ser Arg Arg Glu Ser Ile Asn Pro Trp Ile Leu Thr 
1               5                   10                  15      


Gly Phe Ala Asp Ala Glu Gly Cys Phe Arg Leu Asp Ile Arg Asn Ala 
            20                  25                  30          


Asn Asp Leu Arg Ala Gly Tyr Arg Thr Arg Leu Ala Phe Glu Ile Val 
        35                  40                  45              


Leu His Asn Lys Asp Lys Ser Ile Leu Glu Asn Ile Gln Ser Thr Trp 
    50                  55                  60                  


Lys Val Gly Thr Ile Tyr Asn Ala Gly Asp Asn Ala Val Arg Leu Gln 
65                  70                  75                  80  


Val Thr Arg Phe Glu Asp Leu Lys Val Ile Ile Asp His Phe Glu Lys 
                85                  90                  95      


Tyr Pro Leu Ile Thr Gln Lys Leu Gly Asp Tyr Lys Leu Phe Lys Gln 
            100                 105                 110         


Ala Phe Ser Val Met Glu Asn Lys Glu His Leu Lys Glu Asn Gly Ile 
        115                 120                 125             


Lys Glu Leu Val Arg Ile Lys Ala Lys Met Asn Trp Gly Leu Asn Asp 
    130                 135                 140                 


Glu Leu Lys Lys Ala Phe Pro Glu Asn Ile Ser Lys Glu Arg Ser Leu 
145                 150                 155                 160 


Ile Asn Lys Asn Ile Pro Asn Leu Lys Trp Leu Ala Gly Phe Thr Ser 
                165                 170                 175     


Gly Asp Gly Ser Phe Val Val Glu Leu Lys Lys Arg Arg Ser Pro Val 
            180                 185                 190         


Lys Val Gly Val Arg Leu Arg Phe Ser Ile Thr Gln His Ile Arg Asp 
        195                 200                 205             


Lys Asn Leu Met Asn Ser Leu Ile Thr Tyr Leu Gly Cys Gly Arg Ile 
    210                 215                 220                 


Val Glu Asn Asn Lys Ser Glu His Ser Trp Leu Glu Phe Ile Val Thr 
225                 230                 235                 240 


Lys Phe Ser Asp Ile Asn Asp Lys Ile Ile Pro Val Phe Gln Glu Asn 
                245                 250                 255     


Thr Leu Ile Gly Val Lys Leu Glu Asp Phe Glu Asp Trp Cys Lys Val 
            260                 265                 270         


Ala Lys Leu Ile Glu Glu Lys Lys His Leu Thr Glu Ser Gly Leu Asp 
        275                 280                 285             


Glu Ile Lys Lys Ile Lys Leu Asn Met Asn Lys Gly Arg Xaa Xaa Xaa 
    290                 295                 300                 


Xaa Xaa 
305     


<210>  7
<211>  306
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized I-OnuI variant CBLB.F6


<220>
<221>  MOD_RES
<222>  (1)..(4)
<223>  Any amino acid or absent

<220>
<221>  MOD_RES
<222>  (302)..(306)
<223>  Any amino acid or absent

<400>  7

Xaa Xaa Xaa Xaa Ser Arg Arg Glu Ser Ile Asn Pro Trp Ile Leu Thr 
1               5                   10                  15      


Gly Phe Ala Asp Ala Glu Gly Cys Phe Arg Leu Asp Ile Arg Asn Ala 
            20                  25                  30          


Asn Asp Leu Arg Ala Gly Tyr Arg Thr Arg Leu Ala Phe Glu Ile Val 
        35                  40                  45              


Leu His Asn Lys Asp Lys Ser Ile Leu Glu Asn Ile Gln Ser Thr Trp 
    50                  55                  60                  


Lys Val Gly Thr Ile Tyr Asn Ala Gly Asp Asn Ala Val Arg Leu Gln 
65                  70                  75                  80  


Val Thr Arg Phe Glu Asp Leu Lys Val Ile Ile Asp His Phe Glu Lys 
                85                  90                  95      


Tyr Pro Leu Ile Thr Gln Lys Leu Gly Asp Tyr Lys Leu Phe Lys Gln 
            100                 105                 110         


Ala Phe Ser Val Met Glu Asn Lys Glu His Leu Lys Glu Asn Gly Ile 
        115                 120                 125             


Lys Glu Leu Val Arg Ile Lys Ala Lys Met Asn Trp Gly Leu Asn Asp 
    130                 135                 140                 


Glu Leu Lys Lys Ala Phe Pro Glu Asn Ile Ser Lys Glu Arg Pro Leu 
145                 150                 155                 160 


Ile Asn Lys Asn Ile Pro Asn Leu Lys Trp Leu Ala Gly Phe Thr Ser 
                165                 170                 175     


Gly Asp Gly Ser Phe Met Val Glu Leu Met Lys Asn Lys Asn Asn Val 
            180                 185                 190         


Ile Val Arg Val Arg Leu Arg Phe Ser Ile Ser Gln His Ile Arg Asp 
        195                 200                 205             


Lys Asn Leu Met Asn Ser Leu Ile Thr Tyr Leu Gly Cys Gly Arg Ile 
    210                 215                 220                 


Val Glu Asn Asn Lys Ser Glu His Ser Trp Leu Glu Phe Ile Val Thr 
225                 230                 235                 240 


Lys Phe Ser Asp Ile Asn Asp Lys Ile Ile Pro Val Phe Gln Glu Asn 
                245                 250                 255     


Thr Leu Ile Gly Val Lys Leu Glu Asp Phe Glu Asp Trp Cys Lys Val 
            260                 265                 270         


Ala Lys Leu Ile Glu Glu Lys Lys His Leu Thr Glu Ser Gly Leu Asp 
        275                 280                 285             


Glu Ile Lys Lys Ile Lys Leu Asn Met Asn Lys Gly Arg Xaa Xaa Xaa 
    290                 295                 300                 


Xaa Xaa 
305     


<210>  8
<211>  306
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized I-OnuI variant CBLB.E6


<220>
<221>  MOD_RES
<222>  (1)..(4)
<223>  Any amino acid or absent

<220>
<221>  MOD_RES
<222>  (302)..(306)
<223>  Any amino acid or absent

<400>  8

Xaa Xaa Xaa Xaa Ser Arg Arg Glu Ser Ile Asn Pro Trp Ile Leu Thr 
1               5                   10                  15      


Gly Phe Ala Asp Ala Glu Gly Cys Phe Arg Leu Asp Ile Arg Asn Ala 
            20                  25                  30          


Asn Asp Leu Arg Ala Gly Tyr Arg Thr Arg Leu Ser Phe Glu Ile Ser 
        35                  40                  45              


Leu His Asn Lys Asp Lys Ser Ile Leu Glu Asn Ile Gln Ser Thr Trp 
    50                  55                  60                  


Lys Val Gly Thr Ile Tyr Asn Ala Gly Asp Asn Ala Val Arg Leu Gln 
65                  70                  75                  80  


Val Thr Arg Phe Glu Asp Leu Lys Val Ile Ile Asp His Phe Glu Lys 
                85                  90                  95      


Tyr Pro Leu Ile Thr Gln Lys Leu Gly Asp Tyr Lys Leu Phe Lys Gln 
            100                 105                 110         


Ala Phe Ser Val Met Glu Asn Lys Glu His Leu Lys Glu Asn Gly Ile 
        115                 120                 125             


Lys Glu Leu Val Arg Ile Lys Ala Lys Met Asn Trp Gly Leu Asn Asp 
    130                 135                 140                 


Glu Leu Lys Lys Ala Phe Pro Glu Asn Ile Ser Lys Glu Arg Pro Leu 
145                 150                 155                 160 


Ile Asn Lys Asn Ile Pro Asn Leu Lys Trp Leu Ala Gly Phe Thr Ser 
                165                 170                 175     


Gly Asp Gly Ser Phe Met Val Glu Leu Met Lys Asn Lys Asn Asn Val 
            180                 185                 190         


Ile Val Arg Val Arg Leu Arg Phe Ser Ile Ser Gln His Ile Arg Asp 
        195                 200                 205             


Lys Asn Leu Met Asn Ser Leu Ile Thr Tyr Leu Gly Cys Gly Arg Ile 
    210                 215                 220                 


Val Glu Asn Asn Lys Ser Glu His Ser Trp Leu Glu Phe Ile Val Thr 
225                 230                 235                 240 


Lys Phe Ser Asp Ile Asn Asp Lys Ile Ile Pro Val Phe Gln Glu Asn 
                245                 250                 255     


Thr Leu Ile Gly Val Lys Leu Glu Asp Phe Glu Asp Trp Cys Lys Val 
            260                 265                 270         


Ala Lys Leu Ile Glu Glu Lys Lys His Leu Thr Glu Ser Gly Leu Asp 
        275                 280                 285             


Glu Ile Lys Lys Ile Lys Leu Asn Met Asn Lys Gly Arg Xaa Xaa Xaa 
    290                 295                 300                 


Xaa Xaa 
305     


<210>  9
<211>  306
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized I-OnuI variant CBLB.D2


<220>
<221>  MOD_RES
<222>  (1)..(4)
<223>  Any amino acid or absent

<220>
<221>  MOD_RES
<222>  (302)..(306)
<223>  Any amino acid or absent

<400>  9

Xaa Xaa Xaa Xaa Ser Arg Arg Glu Ser Ile Asn Pro Trp Ile Leu Thr 
1               5                   10                  15      


Gly Phe Ala Asp Ala Glu Gly Cys Phe Arg Leu Asp Ile His Asn Ala 
            20                  25                  30          


Asn Val Leu Arg Ser Gly Tyr Arg Thr Arg Leu Ser Phe Glu Ile Val 
        35                  40                  45              


Leu His Asn Lys Asp Lys Ser Ile Leu Glu Asn Ile Gln Ser Thr Trp 
    50                  55                  60                  


Lys Val Gly Lys Ile Tyr Asn Ala Gly Asp Asn Ala Val Arg Leu Gln 
65                  70                  75                  80  


Val Thr Arg Phe Glu Asp Leu Lys Val Ile Ile Asp His Phe Glu Lys 
                85                  90                  95      


Tyr Pro Leu Ile Thr Gln Lys Leu Gly Asp Tyr Lys Leu Phe Lys Gln 
            100                 105                 110         


Ala Phe Ser Val Met Glu Asn Lys Glu His Leu Lys Glu Asn Gly Ile 
        115                 120                 125             


Lys Glu Leu Val Arg Ile Lys Ala Lys Met Asn Trp Gly Leu Asn Asp 
    130                 135                 140                 


Glu Leu Lys Lys Ala Phe Pro Glu Asn Ile Ser Lys Glu Arg Pro Leu 
145                 150                 155                 160 


Ile Asn Lys Asn Ile Pro Asn Leu Lys Trp Leu Ala Gly Phe Thr Ser 
                165                 170                 175     


Gly Asp Gly Ser Phe Met Val Glu Leu Met Lys Asn Lys Asn Asn Val 
            180                 185                 190         


Ile Val Arg Val Arg Leu Arg Phe Ser Ile Ser Gln His Ile Arg Asp 
        195                 200                 205             


Lys Asn Leu Met Asn Ser Leu Ile Thr Tyr Leu Gly Cys Gly Arg Ile 
    210                 215                 220                 


Val Glu Asn Asn Lys Ser Glu His Ser Trp Leu Glu Phe Ile Val Thr 
225                 230                 235                 240 


Lys Phe Ser Asp Ile Asn Asp Lys Ile Ile Pro Val Phe Gln Glu Asn 
                245                 250                 255     


Thr Leu Ile Gly Val Lys Leu Glu Asp Phe Glu Asp Trp Cys Lys Val 
            260                 265                 270         


Ala Lys Leu Ile Glu Glu Lys Lys His Leu Thr Glu Ser Gly Leu Asp 
        275                 280                 285             


Glu Ile Lys Lys Ile Lys Leu Asn Met Asn Lys Gly Arg Xaa Xaa Xaa 
    290                 295                 300                 


Xaa Xaa 
305     


<210>  10
<211>  306
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized I-OnuI variant CBLB.C2


<220>
<221>  MOD_RES
<222>  (1)..(4)
<223>  Any amino acid or absent

<220>
<221>  MOD_RES
<222>  (302)..(306)
<223>  Any amino acid or absent

<400>  10

Xaa Xaa Xaa Xaa Ser Arg Arg Glu Ser Ile Asn Pro Trp Ile Leu Thr 
1               5                   10                  15      


Gly Phe Ala Asp Ala Glu Gly Cys Phe Gly Leu Tyr Ile His Asn Ser 
            20                  25                  30          


Asn Val Leu Arg Ser Gly Tyr Arg Thr Arg Leu Ser Phe Glu Ile Ser 
        35                  40                  45              


Leu His Asn Lys Asp Lys Ser Ile Leu Glu Asn Ile Gln Ser Thr Trp 
    50                  55                  60                  


Lys Val Gly Thr Ile Tyr Asn Ala Gly Asp Asn Ala Val Arg Leu Gln 
65                  70                  75                  80  


Val Thr Arg Phe Glu Asp Leu Lys Val Ile Ile Asp His Phe Glu Lys 
                85                  90                  95      


Tyr Pro Leu Ile Thr Gln Lys Leu Gly Asp Tyr Lys Leu Phe Lys Gln 
            100                 105                 110         


Ala Phe Ser Leu Met Glu Asn Lys Glu His Leu Lys Glu Asn Gly Ile 
        115                 120                 125             


Lys Glu Leu Val Arg Ile Lys Ala Lys Met Asn Trp Gly Leu Asn Asp 
    130                 135                 140                 


Glu Leu Lys Lys Ala Phe Pro Glu Asn Ile Ser Lys Glu Arg Pro Leu 
145                 150                 155                 160 


Ile Asn Lys Asn Ile Pro Asn Leu Lys Trp Leu Ala Gly Phe Thr Ser 
                165                 170                 175     


Gly Asp Gly Ser Phe Met Val Glu Leu Met Lys Asn Lys Asn Asn Val 
            180                 185                 190         


Ile Val Arg Val Arg Leu Arg Phe Ser Ile Ser Gln His Ile Arg Asp 
        195                 200                 205             


Lys Asn Leu Met Asn Ser Leu Ile Thr Tyr Leu Gly Cys Gly Arg Ile 
    210                 215                 220                 


Val Glu Asn Asn Lys Ser Glu His Ser Trp Leu Glu Phe Ile Val Thr 
225                 230                 235                 240 


Lys Phe Ser Asp Ile Asn Asp Lys Ile Ile Pro Val Phe Gln Glu Asn 
                245                 250                 255     


Thr Leu Ile Gly Val Lys Leu Glu Asp Phe Glu Asp Trp Cys Lys Val 
            260                 265                 270         


Ala Lys Leu Ile Glu Glu Lys Lys His Leu Thr Glu Ser Gly Leu Asp 
        275                 280                 285             


Glu Ile Lys Lys Ile Lys Leu Asn Met Asn Lys Gly Arg Xaa Xaa Xaa 
    290                 295                 300                 


Xaa Xaa 
305     


<210>  11
<211>  306
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized I-OnuI variant CBLB.B5


<220>
<221>  MOD_RES
<222>  (1)..(4)
<223>  Any amino acid or absent

<220>
<221>  MOD_RES
<222>  (302)..(306)
<223>  Any amino acid or absent

<400>  11

Xaa Xaa Xaa Xaa Ser Arg Arg Glu Ser Ile Asn Pro Trp Ile Leu Thr 
1               5                   10                  15      


Gly Phe Ala Asp Ala Glu Gly Cys Phe Arg Leu Asp Ile His Asn Ala 
            20                  25                  30          


Asn Val Leu Arg Ser Gly Tyr Arg Thr Arg Leu Ser Phe Glu Ile Val 
        35                  40                  45              


Leu His Asn Lys Asp Lys Ser Ile Leu Glu Asn Ile Gln Ser Thr Trp 
    50                  55                  60                  


Lys Val Gly Thr Ile Tyr Asn Ala Gly Asp Asn Ala Val Arg Leu Gln 
65                  70                  75                  80  


Val Thr Arg Phe Glu Asp Leu Lys Val Ile Ile Asp His Phe Glu Lys 
                85                  90                  95      


Tyr Pro Leu Ile Thr Gln Lys Leu Gly Asp Tyr Lys Leu Phe Lys Gln 
            100                 105                 110         


Ala Phe Ser Leu Met Glu Asn Lys Glu His Leu Lys Glu Asn Gly Ile 
        115                 120                 125             


Lys Glu Leu Val Arg Ile Lys Ala Lys Met Asn Trp Gly Leu Asn Asp 
    130                 135                 140                 


Glu Leu Lys Lys Ala Phe Pro Glu Asn Ile Ser Lys Glu Arg Pro Leu 
145                 150                 155                 160 


Ile Asn Lys Asn Ile Pro Asn Leu Lys Trp Leu Ala Gly Phe Thr Ser 
                165                 170                 175     


Gly Asp Gly Ser Phe Val Val Glu Leu Lys Lys Arg Arg Ser Pro Val 
            180                 185                 190         


Lys Val Gly Val Arg Leu Arg Phe Gly Ile Thr Gln His Ile Arg Asp 
        195                 200                 205             


Lys Asn Leu Met Asn Ser Leu Ile Thr Tyr Leu Gly Cys Gly Arg Ile 
    210                 215                 220                 


Val Glu Asn Asn Lys Ser Glu His Ser Trp Leu Glu Phe Ile Val Thr 
225                 230                 235                 240 


Lys Phe Ser Asp Ile Asn Asp Lys Ile Ile Pro Val Phe Gln Glu Asn 
                245                 250                 255     


Thr Leu Ile Gly Val Lys Leu Glu Asp Phe Glu Asp Trp Cys Lys Val 
            260                 265                 270         


Ala Lys Leu Ile Glu Glu Lys Lys His Leu Thr Glu Ser Gly Leu Asp 
        275                 280                 285             


Glu Ile Lys Lys Ile Lys Leu Asn Met Asn Lys Gly Arg Xaa Xaa Xaa 
    290                 295                 300                 


Xaa Xaa 
305     


<210>  12
<211>  306
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized I-OnuI variant CBLB.A8


<220>
<221>  MOD_RES
<222>  (1)..(4)
<223>  Any amino acid or absent

<220>
<221>  MOD_RES
<222>  (302)..(306)
<223>  Any amino acid or absent

<400>  12

Xaa Xaa Xaa Xaa Ser Arg Arg Glu Ser Ile Asn Pro Trp Ile Leu Thr 
1               5                   10                  15      


Gly Phe Ala Asp Ala Glu Gly Cys Phe Arg Leu Asp Ile Arg Asn Ala 
            20                  25                  30          


Asn Asp Leu Arg Ala Gly Tyr Arg Thr Arg Leu Ala Phe Glu Ile Val 
        35                  40                  45              


Leu His Asn Lys Asp Lys Ser Ile Leu Glu Asn Ile Gln Ser Thr Trp 
    50                  55                  60                  


Lys Val Gly Thr Ile Tyr Asn Ala Gly Asp Asn Ala Val Arg Leu Gln 
65                  70                  75                  80  


Val Thr Arg Phe Glu Asp Leu Lys Val Ile Ile Gly His Phe Glu Lys 
                85                  90                  95      


Tyr Pro Leu Ile Thr Gln Lys Leu Gly Asp Tyr Lys Leu Phe Lys Gln 
            100                 105                 110         


Ala Phe Ser Val Met Glu Asn Lys Glu His Leu Lys Glu Asn Gly Ile 
        115                 120                 125             


Lys Glu Leu Val Arg Ile Lys Ala Lys Met Asn Trp Gly Leu Asn Asp 
    130                 135                 140                 


Glu Leu Lys Lys Ala Phe Pro Glu Asn Ile Ser Lys Glu Arg Pro Leu 
145                 150                 155                 160 


Ile Asn Lys Asn Ile Pro Asn Leu Lys Trp Leu Ala Gly Phe Thr Ser 
                165                 170                 175     


Gly Asp Gly Ser Phe Met Val Glu Leu Met Lys Asn Lys Asn Asn Val 
            180                 185                 190         


Ile Val Arg Val Arg Leu Arg Phe Ser Ile Ser Gln His Ile Arg Asp 
        195                 200                 205             


Lys Asn Leu Met Asn Ser Leu Ile Thr Tyr Leu Gly Cys Gly Arg Ile 
    210                 215                 220                 


Val Glu Asn Asn Lys Ser Glu His Ser Trp Leu Glu Phe Ile Val Thr 
225                 230                 235                 240 


Lys Phe Ser Asp Ile Asn Asp Lys Ile Ile Pro Val Phe Gln Glu Asn 
                245                 250                 255     


Thr Leu Ile Gly Val Lys Leu Glu Asp Phe Glu Asp Trp Cys Lys Val 
            260                 265                 270         


Ala Lys Leu Ile Glu Glu Lys Lys His Leu Thr Glu Ser Gly Leu Asp 
        275                 280                 285             


Glu Ile Lys Lys Ile Lys Leu Asn Met Asn Lys Gly Arg Xaa Xaa Xaa 
    290                 295                 300                 


Xaa Xaa 
305     


<210>  13
<211>  915
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - synthesized megaTAL CBLB.E3 construct

<400>  13

Met Gly Ser Cys Arg Pro Pro Lys Lys Lys Arg Lys Val Val Asp Leu 
1               5                   10                  15      


Arg Thr Leu Gly Tyr Ser Gln Gln Gln Gln Glu Lys Ile Lys Pro Lys 
            20                  25                  30          


Val Arg Ser Thr Val Ala Gln His His Glu Ala Leu Val Gly His Gly 
        35                  40                  45              


Phe Thr His Ala His Ile Val Ala Leu Ser Gln His Pro Ala Ala Leu 
    50                  55                  60                  


Gly Thr Val Ala Val Thr Tyr Gln His Ile Ile Thr Ala Leu Pro Glu 
65                  70                  75                  80  


Ala Thr His Glu Asp Ile Val Gly Val Gly Lys Gln Trp Ser Gly Ala 
                85                  90                  95      


Arg Ala Leu Glu Ala Leu Leu Thr Asp Ala Gly Glu Leu Arg Gly Pro 
            100                 105                 110         


Pro Leu Gln Leu Asp Thr Gly Gln Leu Val Lys Ile Ala Lys Arg Gly 
        115                 120                 125             


Gly Val Thr Ala Met Glu Ala Val His Ala Ser Arg Asn Ala Leu Thr 
    130                 135                 140                 


Gly Ala Pro Leu Asn Leu Thr Pro Asp Gln Val Val Ala Ile Ala Ser 
145                 150                 155                 160 


Asn Gly Gly Gly Lys Gln Ala Leu Glu Thr Val Gln Arg Leu Leu Pro 
                165                 170                 175     


Val Leu Cys Gln Asp His Gly Leu Thr Pro Asp Gln Val Val Ala Ile 
            180                 185                 190         


Ala Ser Asn Asn Gly Gly Lys Gln Ala Leu Glu Thr Val Gln Arg Leu 
        195                 200                 205             


Leu Pro Val Leu Cys Gln Asp His Gly Leu Thr Pro Asp Gln Val Val 
    210                 215                 220                 


Ala Ile Ala Ser Asn Gly Gly Gly Lys Gln Ala Leu Glu Thr Val Gln 
225                 230                 235                 240 


Arg Leu Leu Pro Val Leu Cys Gln Asp His Gly Leu Thr Pro Asp Gln 
                245                 250                 255     


Val Val Ala Ile Ala Ser Asn Gly Gly Gly Lys Gln Ala Leu Glu Thr 
            260                 265                 270         


Val Gln Arg Leu Leu Pro Val Leu Cys Gln Asp His Gly Leu Thr Pro 
        275                 280                 285             


Asp Gln Val Val Ala Ile Ala Ser Asn Ile Gly Gly Lys Gln Ala Leu 
    290                 295                 300                 


Glu Thr Val Gln Arg Leu Leu Pro Val Leu Cys Gln Asp His Gly Leu 
305                 310                 315                 320 


Thr Pro Asp Gln Val Val Ala Ile Ala Ser Asn Gly Gly Gly Lys Gln 
                325                 330                 335     


Ala Leu Glu Thr Val Gln Arg Leu Leu Pro Val Leu Cys Gln Asp His 
            340                 345                 350         


Gly Leu Thr Pro Asp Gln Val Val Ala Ile Ala Ser Asn Asn Gly Gly 
        355                 360                 365             


Lys Gln Ala Leu Glu Thr Val Gln Arg Leu Leu Pro Val Leu Cys Gln 
    370                 375                 380                 


Asp His Gly Leu Thr Pro Asp Gln Val Val Ala Ile Ala Ser Asn Ile 
385                 390                 395                 400 


Gly Gly Lys Gln Ala Leu Glu Thr Val Gln Arg Leu Leu Pro Val Leu 
                405                 410                 415     


Cys Gln Asp His Gly Leu Thr Pro Asp Gln Val Val Ala Ile Ala Ser 
            420                 425                 430         


Asn Asn Gly Gly Lys Gln Ala Leu Glu Thr Val Gln Arg Leu Leu Pro 
        435                 440                 445             


Val Leu Cys Gln Asp His Gly Leu Thr Pro Asp Gln Val Val Ala Ile 
    450                 455                 460                 


Ala Ser Asn Asn Gly Gly Lys Gln Ala Leu Glu Thr Val Gln Arg Leu 
465                 470                 475                 480 


Leu Pro Val Leu Cys Gln Asp His Gly Leu Thr Pro Asp Gln Val Val 
                485                 490                 495     


Ala Ile Ala Ser Asn Gly Gly Gly Lys Gln Ala Leu Glu Thr Val Gln 
            500                 505                 510         


Arg Leu Leu Pro Val Leu Cys Gln Asp His Gly Leu Thr Pro Asp Gln 
        515                 520                 525             


Val Val Ala Ile Ala Ser Asn Ile Gly Gly Lys Gln Ala Leu Glu Ser 
    530                 535                 540                 


Ile Val Ala Gln Leu Ser Arg Pro Asp Pro Ala Leu Ala Ala Leu Thr 
545                 550                 555                 560 


Asn Asp His Leu Val Ala Leu Ala Cys Leu Gly Gly Arg Pro Ala Met 
                565                 570                 575     


Asp Ala Val Lys Lys Gly Leu Pro His Ala Pro Glu Leu Ile Arg Arg 
            580                 585                 590         


Val Asn Arg Arg Ile Gly Glu Arg Thr Ser His Arg Val Ala Ile Ser 
        595                 600                 605             


Arg Val Gly Gly Ser Ser Arg Arg Glu Ser Ile Asn Pro Trp Ile Leu 
    610                 615                 620                 


Thr Gly Phe Ala Asp Ala Glu Gly Cys Phe Arg Leu Asp Ile Arg Asn 
625                 630                 635                 640 


Ala Asn Asp Leu Arg Ala Gly Tyr Arg Thr Arg Leu Ala Phe Glu Ile 
                645                 650                 655     


Val Leu His Asn Lys Asp Lys Ser Ile Leu Glu Asn Ile Gln Ser Thr 
            660                 665                 670         


Trp Lys Val Gly Thr Ile Tyr Asn Ala Gly Asp Asn Ala Val Arg Leu 
        675                 680                 685             


Gln Val Thr Arg Phe Glu Asp Leu Lys Val Ile Ile Asp His Phe Glu 
    690                 695                 700                 


Lys Tyr Pro Leu Ile Thr Gln Lys Leu Gly Asp Tyr Lys Leu Phe Lys 
705                 710                 715                 720 


Gln Ala Phe Ser Val Met Glu Asn Lys Glu His Leu Lys Glu Asn Gly 
                725                 730                 735     


Ile Lys Glu Leu Val Arg Ile Lys Ala Lys Met Asn Trp Gly Leu Asn 
            740                 745                 750         


Asp Glu Leu Lys Lys Ala Phe Pro Glu Asn Ile Ser Lys Glu Arg Ser 
        755                 760                 765             


Leu Ile Asn Lys Asn Ile Pro Asn Leu Lys Trp Leu Ala Gly Phe Thr 
    770                 775                 780                 


Ser Gly Asp Gly Ser Phe Val Val Glu Leu Lys Lys Arg Arg Ser Pro 
785                 790                 795                 800 


Val Lys Val Gly Val Arg Leu Arg Phe Ser Ile Thr Gln His Ile Arg 
                805                 810                 815     


Asp Lys Asn Leu Met Asn Ser Leu Ile Thr Tyr Leu Gly Cys Gly Arg 
            820                 825                 830         


Ile Val Glu Asn Asn Lys Ser Glu His Ser Trp Leu Glu Phe Ile Val 
        835                 840                 845             


Thr Lys Phe Ser Asp Ile Asn Asp Lys Ile Ile Pro Val Phe Gln Glu 
    850                 855                 860                 


Asn Thr Leu Ile Gly Val Lys Leu Glu Asp Phe Glu Asp Trp Cys Lys 
865                 870                 875                 880 


Val Ala Lys Leu Ile Glu Glu Lys Lys His Leu Thr Glu Ser Gly Leu 
                885                 890                 895     


Asp Glu Ile Lys Lys Ile Lys Leu Asn Met Asn Lys Gly Arg Val Phe 
            900                 905                 910         


Ser Gly Arg 
        915 


<210>  14
<211>  915
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - synthesized megaTAL CBLB.F6 construct

<400>  14

Met Gly Ser Cys Arg Pro Pro Lys Lys Lys Arg Lys Val Val Asp Leu 
1               5                   10                  15      


Arg Thr Leu Gly Tyr Ser Gln Gln Gln Gln Glu Lys Ile Lys Pro Lys 
            20                  25                  30          


Val Arg Ser Thr Val Ala Gln His His Glu Ala Leu Val Gly His Gly 
        35                  40                  45              


Phe Thr His Ala His Ile Val Ala Leu Ser Gln His Pro Ala Ala Leu 
    50                  55                  60                  


Gly Thr Val Ala Val Thr Tyr Gln His Ile Ile Thr Ala Leu Pro Glu 
65                  70                  75                  80  


Ala Thr His Glu Asp Ile Val Gly Val Gly Lys Gln Trp Ser Gly Ala 
                85                  90                  95      


Arg Ala Leu Glu Ala Leu Leu Thr Asp Ala Gly Glu Leu Arg Gly Pro 
            100                 105                 110         


Pro Leu Gln Leu Asp Thr Gly Gln Leu Val Lys Ile Ala Lys Arg Gly 
        115                 120                 125             


Gly Val Thr Ala Met Glu Ala Val His Ala Ser Arg Asn Ala Leu Thr 
    130                 135                 140                 


Gly Ala Pro Leu Asn Leu Thr Pro Asp Gln Val Val Ala Ile Ala Ser 
145                 150                 155                 160 


Asn Gly Gly Gly Lys Gln Ala Leu Glu Thr Val Gln Arg Leu Leu Pro 
                165                 170                 175     


Val Leu Cys Gln Asp His Gly Leu Thr Pro Asp Gln Val Val Ala Ile 
            180                 185                 190         


Ala Ser Asn Asn Gly Gly Lys Gln Ala Leu Glu Thr Val Gln Arg Leu 
        195                 200                 205             


Leu Pro Val Leu Cys Gln Asp His Gly Leu Thr Pro Asp Gln Val Val 
    210                 215                 220                 


Ala Ile Ala Ser Asn Gly Gly Gly Lys Gln Ala Leu Glu Thr Val Gln 
225                 230                 235                 240 


Arg Leu Leu Pro Val Leu Cys Gln Asp His Gly Leu Thr Pro Asp Gln 
                245                 250                 255     


Val Val Ala Ile Ala Ser Asn Gly Gly Gly Lys Gln Ala Leu Glu Thr 
            260                 265                 270         


Val Gln Arg Leu Leu Pro Val Leu Cys Gln Asp His Gly Leu Thr Pro 
        275                 280                 285             


Asp Gln Val Val Ala Ile Ala Ser Asn Ile Gly Gly Lys Gln Ala Leu 
    290                 295                 300                 


Glu Thr Val Gln Arg Leu Leu Pro Val Leu Cys Gln Asp His Gly Leu 
305                 310                 315                 320 


Thr Pro Asp Gln Val Val Ala Ile Ala Ser Asn Gly Gly Gly Lys Gln 
                325                 330                 335     


Ala Leu Glu Thr Val Gln Arg Leu Leu Pro Val Leu Cys Gln Asp His 
            340                 345                 350         


Gly Leu Thr Pro Asp Gln Val Val Ala Ile Ala Ser Asn Asn Gly Gly 
        355                 360                 365             


Lys Gln Ala Leu Glu Thr Val Gln Arg Leu Leu Pro Val Leu Cys Gln 
    370                 375                 380                 


Asp His Gly Leu Thr Pro Asp Gln Val Val Ala Ile Ala Ser Asn Ile 
385                 390                 395                 400 


Gly Gly Lys Gln Ala Leu Glu Thr Val Gln Arg Leu Leu Pro Val Leu 
                405                 410                 415     


Cys Gln Asp His Gly Leu Thr Pro Asp Gln Val Val Ala Ile Ala Ser 
            420                 425                 430         


Asn Asn Gly Gly Lys Gln Ala Leu Glu Thr Val Gln Arg Leu Leu Pro 
        435                 440                 445             


Val Leu Cys Gln Asp His Gly Leu Thr Pro Asp Gln Val Val Ala Ile 
    450                 455                 460                 


Ala Ser Asn Asn Gly Gly Lys Gln Ala Leu Glu Thr Val Gln Arg Leu 
465                 470                 475                 480 


Leu Pro Val Leu Cys Gln Asp His Gly Leu Thr Pro Asp Gln Val Val 
                485                 490                 495     


Ala Ile Ala Ser Asn Gly Gly Gly Lys Gln Ala Leu Glu Thr Val Gln 
            500                 505                 510         


Arg Leu Leu Pro Val Leu Cys Gln Asp His Gly Leu Thr Pro Asp Gln 
        515                 520                 525             


Val Val Ala Ile Ala Ser Asn Ile Gly Gly Lys Gln Ala Leu Glu Ser 
    530                 535                 540                 


Ile Val Ala Gln Leu Ser Arg Pro Asp Pro Ala Leu Ala Ala Leu Thr 
545                 550                 555                 560 


Asn Asp His Leu Val Ala Leu Ala Cys Leu Gly Gly Arg Pro Ala Met 
                565                 570                 575     


Asp Ala Val Lys Lys Gly Leu Pro His Ala Pro Glu Leu Ile Arg Arg 
            580                 585                 590         


Val Asn Arg Arg Ile Gly Glu Arg Thr Ser His Arg Val Ala Ile Ser 
        595                 600                 605             


Arg Val Gly Gly Ser Ser Arg Arg Glu Ser Ile Asn Pro Trp Ile Leu 
    610                 615                 620                 


Thr Gly Phe Ala Asp Ala Glu Gly Cys Phe Arg Leu Asp Ile Arg Asn 
625                 630                 635                 640 


Ala Asn Asp Leu Arg Ala Gly Tyr Arg Thr Arg Leu Ala Phe Glu Ile 
                645                 650                 655     


Val Leu His Asn Lys Asp Lys Ser Ile Leu Glu Asn Ile Gln Ser Thr 
            660                 665                 670         


Trp Lys Val Gly Thr Ile Tyr Asn Ala Gly Asp Asn Ala Val Arg Leu 
        675                 680                 685             


Gln Val Thr Arg Phe Glu Asp Leu Lys Val Ile Ile Asp His Phe Glu 
    690                 695                 700                 


Lys Tyr Pro Leu Ile Thr Gln Lys Leu Gly Asp Tyr Lys Leu Phe Lys 
705                 710                 715                 720 


Gln Ala Phe Ser Val Met Glu Asn Lys Glu His Leu Lys Glu Asn Gly 
                725                 730                 735     


Ile Lys Glu Leu Val Arg Ile Lys Ala Lys Met Asn Trp Gly Leu Asn 
            740                 745                 750         


Asp Glu Leu Lys Lys Ala Phe Pro Glu Asn Ile Ser Lys Glu Arg Pro 
        755                 760                 765             


Leu Ile Asn Lys Asn Ile Pro Asn Leu Lys Trp Leu Ala Gly Phe Thr 
    770                 775                 780                 


Ser Gly Asp Gly Ser Phe Met Val Glu Leu Met Lys Asn Lys Asn Asn 
785                 790                 795                 800 


Val Ile Val Arg Val Arg Leu Arg Phe Ser Ile Ser Gln His Ile Arg 
                805                 810                 815     


Asp Lys Asn Leu Met Asn Ser Leu Ile Thr Tyr Leu Gly Cys Gly Arg 
            820                 825                 830         


Ile Val Glu Asn Asn Lys Ser Glu His Ser Trp Leu Glu Phe Ile Val 
        835                 840                 845             


Thr Lys Phe Ser Asp Ile Asn Asp Lys Ile Ile Pro Val Phe Gln Glu 
    850                 855                 860                 


Asn Thr Leu Ile Gly Val Lys Leu Glu Asp Phe Glu Asp Trp Cys Lys 
865                 870                 875                 880 


Val Ala Lys Leu Ile Glu Glu Lys Lys His Leu Thr Glu Ser Gly Leu 
                885                 890                 895     


Asp Glu Ile Lys Lys Ile Lys Leu Asn Met Asn Lys Gly Arg Val Phe 
            900                 905                 910         


Ser Gly Arg 
        915 


<210>  15
<211>  915
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - synthesized megaTAL CBLB.E6 construct

<400>  15

Met Gly Ser Cys Arg Pro Pro Lys Lys Lys Arg Lys Val Val Asp Leu 
1               5                   10                  15      


Arg Thr Leu Gly Tyr Ser Gln Gln Gln Gln Glu Lys Ile Lys Pro Lys 
            20                  25                  30          


Val Arg Ser Thr Val Ala Gln His His Glu Ala Leu Val Gly His Gly 
        35                  40                  45              


Phe Thr His Ala His Ile Val Ala Leu Ser Gln His Pro Ala Ala Leu 
    50                  55                  60                  


Gly Thr Val Ala Val Thr Tyr Gln His Ile Ile Thr Ala Leu Pro Glu 
65                  70                  75                  80  


Ala Thr His Glu Asp Ile Val Gly Val Gly Lys Gln Trp Ser Gly Ala 
                85                  90                  95      


Arg Ala Leu Glu Ala Leu Leu Thr Asp Ala Gly Glu Leu Arg Gly Pro 
            100                 105                 110         


Pro Leu Gln Leu Asp Thr Gly Gln Leu Val Lys Ile Ala Lys Arg Gly 
        115                 120                 125             


Gly Val Thr Ala Met Glu Ala Val His Ala Ser Arg Asn Ala Leu Thr 
    130                 135                 140                 


Gly Ala Pro Leu Asn Leu Thr Pro Asp Gln Val Val Ala Ile Ala Ser 
145                 150                 155                 160 


Asn Gly Gly Gly Lys Gln Ala Leu Glu Thr Val Gln Arg Leu Leu Pro 
                165                 170                 175     


Val Leu Cys Gln Asp His Gly Leu Thr Pro Asp Gln Val Val Ala Ile 
            180                 185                 190         


Ala Ser Asn Asn Gly Gly Lys Gln Ala Leu Glu Thr Val Gln Arg Leu 
        195                 200                 205             


Leu Pro Val Leu Cys Gln Asp His Gly Leu Thr Pro Asp Gln Val Val 
    210                 215                 220                 


Ala Ile Ala Ser Asn Gly Gly Gly Lys Gln Ala Leu Glu Thr Val Gln 
225                 230                 235                 240 


Arg Leu Leu Pro Val Leu Cys Gln Asp His Gly Leu Thr Pro Asp Gln 
                245                 250                 255     


Val Val Ala Ile Ala Ser Asn Gly Gly Gly Lys Gln Ala Leu Glu Thr 
            260                 265                 270         


Val Gln Arg Leu Leu Pro Val Leu Cys Gln Asp His Gly Leu Thr Pro 
        275                 280                 285             


Asp Gln Val Val Ala Ile Ala Ser Asn Ile Gly Gly Lys Gln Ala Leu 
    290                 295                 300                 


Glu Thr Val Gln Arg Leu Leu Pro Val Leu Cys Gln Asp His Gly Leu 
305                 310                 315                 320 


Thr Pro Asp Gln Val Val Ala Ile Ala Ser Asn Gly Gly Gly Lys Gln 
                325                 330                 335     


Ala Leu Glu Thr Val Gln Arg Leu Leu Pro Val Leu Cys Gln Asp His 
            340                 345                 350         


Gly Leu Thr Pro Asp Gln Val Val Ala Ile Ala Ser Asn Asn Gly Gly 
        355                 360                 365             


Lys Gln Ala Leu Glu Thr Val Gln Arg Leu Leu Pro Val Leu Cys Gln 
    370                 375                 380                 


Asp His Gly Leu Thr Pro Asp Gln Val Val Ala Ile Ala Ser Asn Ile 
385                 390                 395                 400 


Gly Gly Lys Gln Ala Leu Glu Thr Val Gln Arg Leu Leu Pro Val Leu 
                405                 410                 415     


Cys Gln Asp His Gly Leu Thr Pro Asp Gln Val Val Ala Ile Ala Ser 
            420                 425                 430         


Asn Asn Gly Gly Lys Gln Ala Leu Glu Thr Val Gln Arg Leu Leu Pro 
        435                 440                 445             


Val Leu Cys Gln Asp His Gly Leu Thr Pro Asp Gln Val Val Ala Ile 
    450                 455                 460                 


Ala Ser Asn Asn Gly Gly Lys Gln Ala Leu Glu Thr Val Gln Arg Leu 
465                 470                 475                 480 


Leu Pro Val Leu Cys Gln Asp His Gly Leu Thr Pro Asp Gln Val Val 
                485                 490                 495     


Ala Ile Ala Ser Asn Gly Gly Gly Lys Gln Ala Leu Glu Thr Val Gln 
            500                 505                 510         


Arg Leu Leu Pro Val Leu Cys Gln Asp His Gly Leu Thr Pro Asp Gln 
        515                 520                 525             


Val Val Ala Ile Ala Ser Asn Ile Gly Gly Lys Gln Ala Leu Glu Ser 
    530                 535                 540                 


Ile Val Ala Gln Leu Ser Arg Pro Asp Pro Ala Leu Ala Ala Leu Thr 
545                 550                 555                 560 


Asn Asp His Leu Val Ala Leu Ala Cys Leu Gly Gly Arg Pro Ala Met 
                565                 570                 575     


Asp Ala Val Lys Lys Gly Leu Pro His Ala Pro Glu Leu Ile Arg Arg 
            580                 585                 590         


Val Asn Arg Arg Ile Gly Glu Arg Thr Ser His Arg Val Ala Ile Ser 
        595                 600                 605             


Arg Val Gly Gly Ser Ser Arg Arg Glu Ser Ile Asn Pro Trp Ile Leu 
    610                 615                 620                 


Thr Gly Phe Ala Asp Ala Glu Gly Cys Phe Arg Leu Asp Ile Arg Asn 
625                 630                 635                 640 


Ala Asn Asp Leu Arg Ala Gly Tyr Arg Thr Arg Leu Ser Phe Glu Ile 
                645                 650                 655     


Ser Leu His Asn Lys Asp Lys Ser Ile Leu Glu Asn Ile Gln Ser Thr 
            660                 665                 670         


Trp Lys Val Gly Thr Ile Tyr Asn Ala Gly Asp Asn Ala Val Arg Leu 
        675                 680                 685             


Gln Val Thr Arg Phe Glu Asp Leu Lys Val Ile Ile Asp His Phe Glu 
    690                 695                 700                 


Lys Tyr Pro Leu Ile Thr Gln Lys Leu Gly Asp Tyr Lys Leu Phe Lys 
705                 710                 715                 720 


Gln Ala Phe Ser Val Met Glu Asn Lys Glu His Leu Lys Glu Asn Gly 
                725                 730                 735     


Ile Lys Glu Leu Val Arg Ile Lys Ala Lys Met Asn Trp Gly Leu Asn 
            740                 745                 750         


Asp Glu Leu Lys Lys Ala Phe Pro Glu Asn Ile Ser Lys Glu Arg Pro 
        755                 760                 765             


Leu Ile Asn Lys Asn Ile Pro Asn Leu Lys Trp Leu Ala Gly Phe Thr 
    770                 775                 780                 


Ser Gly Asp Gly Ser Phe Met Val Glu Leu Met Lys Asn Lys Asn Asn 
785                 790                 795                 800 


Val Ile Val Arg Val Arg Leu Arg Phe Ser Ile Ser Gln His Ile Arg 
                805                 810                 815     


Asp Lys Asn Leu Met Asn Ser Leu Ile Thr Tyr Leu Gly Cys Gly Arg 
            820                 825                 830         


Ile Val Glu Asn Asn Lys Ser Glu His Ser Trp Leu Glu Phe Ile Val 
        835                 840                 845             


Thr Lys Phe Ser Asp Ile Asn Asp Lys Ile Ile Pro Val Phe Gln Glu 
    850                 855                 860                 


Asn Thr Leu Ile Gly Val Lys Leu Glu Asp Phe Glu Asp Trp Cys Lys 
865                 870                 875                 880 


Val Ala Lys Leu Ile Glu Glu Lys Lys His Leu Thr Glu Ser Gly Leu 
                885                 890                 895     


Asp Glu Ile Lys Lys Ile Lys Leu Asn Met Asn Lys Gly Arg Val Phe 
            900                 905                 910         


Ser Gly Arg 
        915 


<210>  16
<211>  915
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - synthesized megaTAL CBLB.D2 construct

<400>  16

Met Gly Ser Cys Arg Pro Pro Lys Lys Lys Arg Lys Val Val Asp Leu 
1               5                   10                  15      


Arg Thr Leu Gly Tyr Ser Gln Gln Gln Gln Glu Lys Ile Lys Pro Lys 
            20                  25                  30          


Val Arg Ser Thr Val Ala Gln His His Glu Ala Leu Val Gly His Gly 
        35                  40                  45              


Phe Thr His Ala His Ile Val Ala Leu Ser Gln His Pro Ala Ala Leu 
    50                  55                  60                  


Gly Thr Val Ala Val Thr Tyr Gln His Ile Ile Thr Ala Leu Pro Glu 
65                  70                  75                  80  


Ala Thr His Glu Asp Ile Val Gly Val Gly Lys Gln Trp Ser Gly Ala 
                85                  90                  95      


Arg Ala Leu Glu Ala Leu Leu Thr Asp Ala Gly Glu Leu Arg Gly Pro 
            100                 105                 110         


Pro Leu Gln Leu Asp Thr Gly Gln Leu Val Lys Ile Ala Lys Arg Gly 
        115                 120                 125             


Gly Val Thr Ala Met Glu Ala Val His Ala Ser Arg Asn Ala Leu Thr 
    130                 135                 140                 


Gly Ala Pro Leu Asn Leu Thr Pro Asp Gln Val Val Ala Ile Ala Ser 
145                 150                 155                 160 


Asn Gly Gly Gly Lys Gln Ala Leu Glu Thr Val Gln Arg Leu Leu Pro 
                165                 170                 175     


Val Leu Cys Gln Asp His Gly Leu Thr Pro Asp Gln Val Val Ala Ile 
            180                 185                 190         


Ala Ser Asn Asn Gly Gly Lys Gln Ala Leu Glu Thr Val Gln Arg Leu 
        195                 200                 205             


Leu Pro Val Leu Cys Gln Asp His Gly Leu Thr Pro Asp Gln Val Val 
    210                 215                 220                 


Ala Ile Ala Ser Asn Gly Gly Gly Lys Gln Ala Leu Glu Thr Val Gln 
225                 230                 235                 240 


Arg Leu Leu Pro Val Leu Cys Gln Asp His Gly Leu Thr Pro Asp Gln 
                245                 250                 255     


Val Val Ala Ile Ala Ser Asn Gly Gly Gly Lys Gln Ala Leu Glu Thr 
            260                 265                 270         


Val Gln Arg Leu Leu Pro Val Leu Cys Gln Asp His Gly Leu Thr Pro 
        275                 280                 285             


Asp Gln Val Val Ala Ile Ala Ser Asn Ile Gly Gly Lys Gln Ala Leu 
    290                 295                 300                 


Glu Thr Val Gln Arg Leu Leu Pro Val Leu Cys Gln Asp His Gly Leu 
305                 310                 315                 320 


Thr Pro Asp Gln Val Val Ala Ile Ala Ser Asn Gly Gly Gly Lys Gln 
                325                 330                 335     


Ala Leu Glu Thr Val Gln Arg Leu Leu Pro Val Leu Cys Gln Asp His 
            340                 345                 350         


Gly Leu Thr Pro Asp Gln Val Val Ala Ile Ala Ser Asn Asn Gly Gly 
        355                 360                 365             


Lys Gln Ala Leu Glu Thr Val Gln Arg Leu Leu Pro Val Leu Cys Gln 
    370                 375                 380                 


Asp His Gly Leu Thr Pro Asp Gln Val Val Ala Ile Ala Ser Asn Ile 
385                 390                 395                 400 


Gly Gly Lys Gln Ala Leu Glu Thr Val Gln Arg Leu Leu Pro Val Leu 
                405                 410                 415     


Cys Gln Asp His Gly Leu Thr Pro Asp Gln Val Val Ala Ile Ala Ser 
            420                 425                 430         


Asn Asn Gly Gly Lys Gln Ala Leu Glu Thr Val Gln Arg Leu Leu Pro 
        435                 440                 445             


Val Leu Cys Gln Asp His Gly Leu Thr Pro Asp Gln Val Val Ala Ile 
    450                 455                 460                 


Ala Ser Asn Asn Gly Gly Lys Gln Ala Leu Glu Thr Val Gln Arg Leu 
465                 470                 475                 480 


Leu Pro Val Leu Cys Gln Asp His Gly Leu Thr Pro Asp Gln Val Val 
                485                 490                 495     


Ala Ile Ala Ser Asn Gly Gly Gly Lys Gln Ala Leu Glu Thr Val Gln 
            500                 505                 510         


Arg Leu Leu Pro Val Leu Cys Gln Asp His Gly Leu Thr Pro Asp Gln 
        515                 520                 525             


Val Val Ala Ile Ala Ser Asn Ile Gly Gly Lys Gln Ala Leu Glu Ser 
    530                 535                 540                 


Ile Val Ala Gln Leu Ser Arg Pro Asp Pro Ala Leu Ala Ala Leu Thr 
545                 550                 555                 560 


Asn Asp His Leu Val Ala Leu Ala Cys Leu Gly Gly Arg Pro Ala Met 
                565                 570                 575     


Asp Ala Val Lys Lys Gly Leu Pro His Ala Pro Glu Leu Ile Arg Arg 
            580                 585                 590         


Val Asn Arg Arg Ile Gly Glu Arg Thr Ser His Arg Val Ala Ile Ser 
        595                 600                 605             


Arg Val Gly Gly Ser Ser Arg Arg Glu Ser Ile Asn Pro Trp Ile Leu 
    610                 615                 620                 


Thr Gly Phe Ala Asp Ala Glu Gly Cys Phe Arg Leu Asp Ile His Asn 
625                 630                 635                 640 


Ala Asn Val Leu Arg Ser Gly Tyr Arg Thr Arg Leu Ser Phe Glu Ile 
                645                 650                 655     


Val Leu His Asn Lys Asp Lys Ser Ile Leu Glu Asn Ile Gln Ser Thr 
            660                 665                 670         


Trp Lys Val Gly Lys Ile Tyr Asn Ala Gly Asp Asn Ala Val Arg Leu 
        675                 680                 685             


Gln Val Thr Arg Phe Glu Asp Leu Lys Val Ile Ile Asp His Phe Glu 
    690                 695                 700                 


Lys Tyr Pro Leu Ile Thr Gln Lys Leu Gly Asp Tyr Lys Leu Phe Lys 
705                 710                 715                 720 


Gln Ala Phe Ser Val Met Glu Asn Lys Glu His Leu Lys Glu Asn Gly 
                725                 730                 735     


Ile Lys Glu Leu Val Arg Ile Lys Ala Lys Met Asn Trp Gly Leu Asn 
            740                 745                 750         


Asp Glu Leu Lys Lys Ala Phe Pro Glu Asn Ile Ser Lys Glu Arg Pro 
        755                 760                 765             


Leu Ile Asn Lys Asn Ile Pro Asn Leu Lys Trp Leu Ala Gly Phe Thr 
    770                 775                 780                 


Ser Gly Asp Gly Ser Phe Met Val Glu Leu Met Lys Asn Lys Asn Asn 
785                 790                 795                 800 


Val Ile Val Arg Val Arg Leu Arg Phe Ser Ile Ser Gln His Ile Arg 
                805                 810                 815     


Asp Lys Asn Leu Met Asn Ser Leu Ile Thr Tyr Leu Gly Cys Gly Arg 
            820                 825                 830         


Ile Val Glu Asn Asn Lys Ser Glu His Ser Trp Leu Glu Phe Ile Val 
        835                 840                 845             


Thr Lys Phe Ser Asp Ile Asn Asp Lys Ile Ile Pro Val Phe Gln Glu 
    850                 855                 860                 


Asn Thr Leu Ile Gly Val Lys Leu Glu Asp Phe Glu Asp Trp Cys Lys 
865                 870                 875                 880 


Val Ala Lys Leu Ile Glu Glu Lys Lys His Leu Thr Glu Ser Gly Leu 
                885                 890                 895     


Asp Glu Ile Lys Lys Ile Lys Leu Asn Met Asn Lys Gly Arg Val Phe 
            900                 905                 910         


Ser Gly Arg 
        915 


<210>  17
<211>  915
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - synthesized megaTAL CBLB.C2 construct

<400>  17

Met Gly Ser Cys Arg Pro Pro Lys Lys Lys Arg Lys Val Val Asp Leu 
1               5                   10                  15      


Arg Thr Leu Gly Tyr Ser Gln Gln Gln Gln Glu Lys Ile Lys Pro Lys 
            20                  25                  30          


Val Arg Ser Thr Val Ala Gln His His Glu Ala Leu Val Gly His Gly 
        35                  40                  45              


Phe Thr His Ala His Ile Val Ala Leu Ser Gln His Pro Ala Ala Leu 
    50                  55                  60                  


Gly Thr Val Ala Val Thr Tyr Gln His Ile Ile Thr Ala Leu Pro Glu 
65                  70                  75                  80  


Ala Thr His Glu Asp Ile Val Gly Val Gly Lys Gln Trp Ser Gly Ala 
                85                  90                  95      


Arg Ala Leu Glu Ala Leu Leu Thr Asp Ala Gly Glu Leu Arg Gly Pro 
            100                 105                 110         


Pro Leu Gln Leu Asp Thr Gly Gln Leu Val Lys Ile Ala Lys Arg Gly 
        115                 120                 125             


Gly Val Thr Ala Met Glu Ala Val His Ala Ser Arg Asn Ala Leu Thr 
    130                 135                 140                 


Gly Ala Pro Leu Asn Leu Thr Pro Asp Gln Val Val Ala Ile Ala Ser 
145                 150                 155                 160 


Asn Gly Gly Gly Lys Gln Ala Leu Glu Thr Val Gln Arg Leu Leu Pro 
                165                 170                 175     


Val Leu Cys Gln Asp His Gly Leu Thr Pro Asp Gln Val Val Ala Ile 
            180                 185                 190         


Ala Ser Asn Asn Gly Gly Lys Gln Ala Leu Glu Thr Val Gln Arg Leu 
        195                 200                 205             


Leu Pro Val Leu Cys Gln Asp His Gly Leu Thr Pro Asp Gln Val Val 
    210                 215                 220                 


Ala Ile Ala Ser Asn Gly Gly Gly Lys Gln Ala Leu Glu Thr Val Gln 
225                 230                 235                 240 


Arg Leu Leu Pro Val Leu Cys Gln Asp His Gly Leu Thr Pro Asp Gln 
                245                 250                 255     


Val Val Ala Ile Ala Ser Asn Gly Gly Gly Lys Gln Ala Leu Glu Thr 
            260                 265                 270         


Val Gln Arg Leu Leu Pro Val Leu Cys Gln Asp His Gly Leu Thr Pro 
        275                 280                 285             


Asp Gln Val Val Ala Ile Ala Ser Asn Ile Gly Gly Lys Gln Ala Leu 
    290                 295                 300                 


Glu Thr Val Gln Arg Leu Leu Pro Val Leu Cys Gln Asp His Gly Leu 
305                 310                 315                 320 


Thr Pro Asp Gln Val Val Ala Ile Ala Ser Asn Gly Gly Gly Lys Gln 
                325                 330                 335     


Ala Leu Glu Thr Val Gln Arg Leu Leu Pro Val Leu Cys Gln Asp His 
            340                 345                 350         


Gly Leu Thr Pro Asp Gln Val Val Ala Ile Ala Ser Asn Asn Gly Gly 
        355                 360                 365             


Lys Gln Ala Leu Glu Thr Val Gln Arg Leu Leu Pro Val Leu Cys Gln 
    370                 375                 380                 


Asp His Gly Leu Thr Pro Asp Gln Val Val Ala Ile Ala Ser Asn Ile 
385                 390                 395                 400 


Gly Gly Lys Gln Ala Leu Glu Thr Val Gln Arg Leu Leu Pro Val Leu 
                405                 410                 415     


Cys Gln Asp His Gly Leu Thr Pro Asp Gln Val Val Ala Ile Ala Ser 
            420                 425                 430         


Asn Asn Gly Gly Lys Gln Ala Leu Glu Thr Val Gln Arg Leu Leu Pro 
        435                 440                 445             


Val Leu Cys Gln Asp His Gly Leu Thr Pro Asp Gln Val Val Ala Ile 
    450                 455                 460                 


Ala Ser Asn Asn Gly Gly Lys Gln Ala Leu Glu Thr Val Gln Arg Leu 
465                 470                 475                 480 


Leu Pro Val Leu Cys Gln Asp His Gly Leu Thr Pro Asp Gln Val Val 
                485                 490                 495     


Ala Ile Ala Ser Asn Gly Gly Gly Lys Gln Ala Leu Glu Thr Val Gln 
            500                 505                 510         


Arg Leu Leu Pro Val Leu Cys Gln Asp His Gly Leu Thr Pro Asp Gln 
        515                 520                 525             


Val Val Ala Ile Ala Ser Asn Ile Gly Gly Lys Gln Ala Leu Glu Ser 
    530                 535                 540                 


Ile Val Ala Gln Leu Ser Arg Pro Asp Pro Ala Leu Ala Ala Leu Thr 
545                 550                 555                 560 


Asn Asp His Leu Val Ala Leu Ala Cys Leu Gly Gly Arg Pro Ala Met 
                565                 570                 575     


Asp Ala Val Lys Lys Gly Leu Pro His Ala Pro Glu Leu Ile Arg Arg 
            580                 585                 590         


Val Asn Arg Arg Ile Gly Glu Arg Thr Ser His Arg Val Ala Ile Ser 
        595                 600                 605             


Arg Val Gly Gly Ser Ser Arg Arg Glu Ser Ile Asn Pro Trp Ile Leu 
    610                 615                 620                 


Thr Gly Phe Ala Asp Ala Glu Gly Cys Phe Gly Leu Tyr Ile His Asn 
625                 630                 635                 640 


Ser Asn Val Leu Arg Ser Gly Tyr Arg Thr Arg Leu Ser Phe Glu Ile 
                645                 650                 655     


Ser Leu His Asn Lys Asp Lys Ser Ile Leu Glu Asn Ile Gln Ser Thr 
            660                 665                 670         


Trp Lys Val Gly Thr Ile Tyr Asn Ala Gly Asp Asn Ala Val Arg Leu 
        675                 680                 685             


Gln Val Thr Arg Phe Glu Asp Leu Lys Val Ile Ile Asp His Phe Glu 
    690                 695                 700                 


Lys Tyr Pro Leu Ile Thr Gln Lys Leu Gly Asp Tyr Lys Leu Phe Lys 
705                 710                 715                 720 


Gln Ala Phe Ser Leu Met Glu Asn Lys Glu His Leu Lys Glu Asn Gly 
                725                 730                 735     


Ile Lys Glu Leu Val Arg Ile Lys Ala Lys Met Asn Trp Gly Leu Asn 
            740                 745                 750         


Asp Glu Leu Lys Lys Ala Phe Pro Glu Asn Ile Ser Lys Glu Arg Pro 
        755                 760                 765             


Leu Ile Asn Lys Asn Ile Pro Asn Leu Lys Trp Leu Ala Gly Phe Thr 
    770                 775                 780                 


Ser Gly Asp Gly Ser Phe Met Val Glu Leu Met Lys Asn Lys Asn Asn 
785                 790                 795                 800 


Val Ile Val Arg Val Arg Leu Arg Phe Ser Ile Ser Gln His Ile Arg 
                805                 810                 815     


Asp Lys Asn Leu Met Asn Ser Leu Ile Thr Tyr Leu Gly Cys Gly Arg 
            820                 825                 830         


Ile Val Glu Asn Asn Lys Ser Glu His Ser Trp Leu Glu Phe Ile Val 
        835                 840                 845             


Thr Lys Phe Ser Asp Ile Asn Asp Lys Ile Ile Pro Val Phe Gln Glu 
    850                 855                 860                 


Asn Thr Leu Ile Gly Val Lys Leu Glu Asp Phe Glu Asp Trp Cys Lys 
865                 870                 875                 880 


Val Ala Lys Leu Ile Glu Glu Lys Lys His Leu Thr Glu Ser Gly Leu 
                885                 890                 895     


Asp Glu Ile Lys Lys Ile Lys Leu Asn Met Asn Lys Gly Arg Val Phe 
            900                 905                 910         


Ser Gly Arg 
        915 


<210>  18
<211>  915
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - synthesized megaTAL CBLB.B5 construct

<400>  18

Met Gly Ser Cys Arg Pro Pro Lys Lys Lys Arg Lys Val Val Asp Leu 
1               5                   10                  15      


Arg Thr Leu Gly Tyr Ser Gln Gln Gln Gln Glu Lys Ile Lys Pro Lys 
            20                  25                  30          


Val Arg Ser Thr Val Ala Gln His His Glu Ala Leu Val Gly His Gly 
        35                  40                  45              


Phe Thr His Ala His Ile Val Ala Leu Ser Gln His Pro Ala Ala Leu 
    50                  55                  60                  


Gly Thr Val Ala Val Thr Tyr Gln His Ile Ile Thr Ala Leu Pro Glu 
65                  70                  75                  80  


Ala Thr His Glu Asp Ile Val Gly Val Gly Lys Gln Trp Ser Gly Ala 
                85                  90                  95      


Arg Ala Leu Glu Ala Leu Leu Thr Asp Ala Gly Glu Leu Arg Gly Pro 
            100                 105                 110         


Pro Leu Gln Leu Asp Thr Gly Gln Leu Val Lys Ile Ala Lys Arg Gly 
        115                 120                 125             


Gly Val Thr Ala Met Glu Ala Val His Ala Ser Arg Asn Ala Leu Thr 
    130                 135                 140                 


Gly Ala Pro Leu Asn Leu Thr Pro Asp Gln Val Val Ala Ile Ala Ser 
145                 150                 155                 160 


Asn Gly Gly Gly Lys Gln Ala Leu Glu Thr Val Gln Arg Leu Leu Pro 
                165                 170                 175     


Val Leu Cys Gln Asp His Gly Leu Thr Pro Asp Gln Val Val Ala Ile 
            180                 185                 190         


Ala Ser Asn Asn Gly Gly Lys Gln Ala Leu Glu Thr Val Gln Arg Leu 
        195                 200                 205             


Leu Pro Val Leu Cys Gln Asp His Gly Leu Thr Pro Asp Gln Val Val 
    210                 215                 220                 


Ala Ile Ala Ser Asn Gly Gly Gly Lys Gln Ala Leu Glu Thr Val Gln 
225                 230                 235                 240 


Arg Leu Leu Pro Val Leu Cys Gln Asp His Gly Leu Thr Pro Asp Gln 
                245                 250                 255     


Val Val Ala Ile Ala Ser Asn Gly Gly Gly Lys Gln Ala Leu Glu Thr 
            260                 265                 270         


Val Gln Arg Leu Leu Pro Val Leu Cys Gln Asp His Gly Leu Thr Pro 
        275                 280                 285             


Asp Gln Val Val Ala Ile Ala Ser Asn Ile Gly Gly Lys Gln Ala Leu 
    290                 295                 300                 


Glu Thr Val Gln Arg Leu Leu Pro Val Leu Cys Gln Asp His Gly Leu 
305                 310                 315                 320 


Thr Pro Asp Gln Val Val Ala Ile Ala Ser Asn Gly Gly Gly Lys Gln 
                325                 330                 335     


Ala Leu Glu Thr Val Gln Arg Leu Leu Pro Val Leu Cys Gln Asp His 
            340                 345                 350         


Gly Leu Thr Pro Asp Gln Val Val Ala Ile Ala Ser Asn Asn Gly Gly 
        355                 360                 365             


Lys Gln Ala Leu Glu Thr Val Gln Arg Leu Leu Pro Val Leu Cys Gln 
    370                 375                 380                 


Asp His Gly Leu Thr Pro Asp Gln Val Val Ala Ile Ala Ser Asn Ile 
385                 390                 395                 400 


Gly Gly Lys Gln Ala Leu Glu Thr Val Gln Arg Leu Leu Pro Val Leu 
                405                 410                 415     


Cys Gln Asp His Gly Leu Thr Pro Asp Gln Val Val Ala Ile Ala Ser 
            420                 425                 430         


Asn Asn Gly Gly Lys Gln Ala Leu Glu Thr Val Gln Arg Leu Leu Pro 
        435                 440                 445             


Val Leu Cys Gln Asp His Gly Leu Thr Pro Asp Gln Val Val Ala Ile 
    450                 455                 460                 


Ala Ser Asn Asn Gly Gly Lys Gln Ala Leu Glu Thr Val Gln Arg Leu 
465                 470                 475                 480 


Leu Pro Val Leu Cys Gln Asp His Gly Leu Thr Pro Asp Gln Val Val 
                485                 490                 495     


Ala Ile Ala Ser Asn Gly Gly Gly Lys Gln Ala Leu Glu Thr Val Gln 
            500                 505                 510         


Arg Leu Leu Pro Val Leu Cys Gln Asp His Gly Leu Thr Pro Asp Gln 
        515                 520                 525             


Val Val Ala Ile Ala Ser Asn Ile Gly Gly Lys Gln Ala Leu Glu Ser 
    530                 535                 540                 


Ile Val Ala Gln Leu Ser Arg Pro Asp Pro Ala Leu Ala Ala Leu Thr 
545                 550                 555                 560 


Asn Asp His Leu Val Ala Leu Ala Cys Leu Gly Gly Arg Pro Ala Met 
                565                 570                 575     


Asp Ala Val Lys Lys Gly Leu Pro His Ala Pro Glu Leu Ile Arg Arg 
            580                 585                 590         


Val Asn Arg Arg Ile Gly Glu Arg Thr Ser His Arg Val Ala Ile Ser 
        595                 600                 605             


Arg Val Gly Gly Ser Ser Arg Arg Glu Ser Ile Asn Pro Trp Ile Leu 
    610                 615                 620                 


Thr Gly Phe Ala Asp Ala Glu Gly Cys Phe Arg Leu Asp Ile His Asn 
625                 630                 635                 640 


Ala Asn Val Leu Arg Ser Gly Tyr Arg Thr Arg Leu Ser Phe Glu Ile 
                645                 650                 655     


Val Leu His Asn Lys Asp Lys Ser Ile Leu Glu Asn Ile Gln Ser Thr 
            660                 665                 670         


Trp Lys Val Gly Thr Ile Tyr Asn Ala Gly Asp Asn Ala Val Arg Leu 
        675                 680                 685             


Gln Val Thr Arg Phe Glu Asp Leu Lys Val Ile Ile Asp His Phe Glu 
    690                 695                 700                 


Lys Tyr Pro Leu Ile Thr Gln Lys Leu Gly Asp Tyr Lys Leu Phe Lys 
705                 710                 715                 720 


Gln Ala Phe Ser Leu Met Glu Asn Lys Glu His Leu Lys Glu Asn Gly 
                725                 730                 735     


Ile Lys Glu Leu Val Arg Ile Lys Ala Lys Met Asn Trp Gly Leu Asn 
            740                 745                 750         


Asp Glu Leu Lys Lys Ala Phe Pro Glu Asn Ile Ser Lys Glu Arg Pro 
        755                 760                 765             


Leu Ile Asn Lys Asn Ile Pro Asn Leu Lys Trp Leu Ala Gly Phe Thr 
    770                 775                 780                 


Ser Gly Asp Gly Ser Phe Val Val Glu Leu Lys Lys Arg Arg Ser Pro 
785                 790                 795                 800 


Val Lys Val Gly Val Arg Leu Arg Phe Gly Ile Thr Gln His Ile Arg 
                805                 810                 815     


Asp Lys Asn Leu Met Asn Ser Leu Ile Thr Tyr Leu Gly Cys Gly Arg 
            820                 825                 830         


Ile Val Glu Asn Asn Lys Ser Glu His Ser Trp Leu Glu Phe Ile Val 
        835                 840                 845             


Thr Lys Phe Ser Asp Ile Asn Asp Lys Ile Ile Pro Val Phe Gln Glu 
    850                 855                 860                 


Asn Thr Leu Ile Gly Val Lys Leu Glu Asp Phe Glu Asp Trp Cys Lys 
865                 870                 875                 880 


Val Ala Lys Leu Ile Glu Glu Lys Lys His Leu Thr Glu Ser Gly Leu 
                885                 890                 895     


Asp Glu Ile Lys Lys Ile Lys Leu Asn Met Asn Lys Gly Arg Val Phe 
            900                 905                 910         


Ser Gly Arg 
        915 


<210>  19
<211>  915
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - synthesized megaTAL CBLB.A8 construct

<400>  19

Met Gly Ser Cys Arg Pro Pro Lys Lys Lys Arg Lys Val Val Asp Leu 
1               5                   10                  15      


Arg Thr Leu Gly Tyr Ser Gln Gln Gln Gln Glu Lys Ile Lys Pro Lys 
            20                  25                  30          


Val Arg Ser Thr Val Ala Gln His His Glu Ala Leu Val Gly His Gly 
        35                  40                  45              


Phe Thr His Ala His Ile Val Ala Leu Ser Gln His Pro Ala Ala Leu 
    50                  55                  60                  


Gly Thr Val Ala Val Thr Tyr Gln His Ile Ile Thr Ala Leu Pro Glu 
65                  70                  75                  80  


Ala Thr His Glu Asp Ile Val Gly Val Gly Lys Gln Trp Ser Gly Ala 
                85                  90                  95      


Arg Ala Leu Glu Ala Leu Leu Thr Asp Ala Gly Glu Leu Arg Gly Pro 
            100                 105                 110         


Pro Leu Gln Leu Asp Thr Gly Gln Leu Val Lys Ile Ala Lys Arg Gly 
        115                 120                 125             


Gly Val Thr Ala Met Glu Ala Val His Ala Ser Arg Asn Ala Leu Thr 
    130                 135                 140                 


Gly Ala Pro Leu Asn Leu Thr Pro Asp Gln Val Val Ala Ile Ala Ser 
145                 150                 155                 160 


Asn Gly Gly Gly Lys Gln Ala Leu Glu Thr Val Gln Arg Leu Leu Pro 
                165                 170                 175     


Val Leu Cys Gln Asp His Gly Leu Thr Pro Asp Gln Val Val Ala Ile 
            180                 185                 190         


Ala Ser Asn Asn Gly Gly Lys Gln Ala Leu Glu Thr Val Gln Arg Leu 
        195                 200                 205             


Leu Pro Val Leu Cys Gln Asp His Gly Leu Thr Pro Asp Gln Val Val 
    210                 215                 220                 


Ala Ile Ala Ser Asn Gly Gly Gly Lys Gln Ala Leu Glu Thr Val Gln 
225                 230                 235                 240 


Arg Leu Leu Pro Val Leu Cys Gln Asp His Gly Leu Thr Pro Asp Gln 
                245                 250                 255     


Val Val Ala Ile Ala Ser Asn Gly Gly Gly Lys Gln Ala Leu Glu Thr 
            260                 265                 270         


Val Gln Arg Leu Leu Pro Val Leu Cys Gln Asp His Gly Leu Thr Pro 
        275                 280                 285             


Asp Gln Val Val Ala Ile Ala Ser Asn Ile Gly Gly Lys Gln Ala Leu 
    290                 295                 300                 


Glu Thr Val Gln Arg Leu Leu Pro Val Leu Cys Gln Asp His Gly Leu 
305                 310                 315                 320 


Thr Pro Asp Gln Val Val Ala Ile Ala Ser Asn Gly Gly Gly Lys Gln 
                325                 330                 335     


Ala Leu Glu Thr Val Gln Arg Leu Leu Pro Val Leu Cys Gln Asp His 
            340                 345                 350         


Gly Leu Thr Pro Asp Gln Val Val Ala Ile Ala Ser Asn Asn Gly Gly 
        355                 360                 365             


Lys Gln Ala Leu Glu Thr Val Gln Arg Leu Leu Pro Val Leu Cys Gln 
    370                 375                 380                 


Asp His Gly Leu Thr Pro Asp Gln Val Val Ala Ile Ala Ser Asn Ile 
385                 390                 395                 400 


Gly Gly Lys Gln Ala Leu Glu Thr Val Gln Arg Leu Leu Pro Val Leu 
                405                 410                 415     


Cys Gln Asp His Gly Leu Thr Pro Asp Gln Val Val Ala Ile Ala Ser 
            420                 425                 430         


Asn Asn Gly Gly Lys Gln Ala Leu Glu Thr Val Gln Arg Leu Leu Pro 
        435                 440                 445             


Val Leu Cys Gln Asp His Gly Leu Thr Pro Asp Gln Val Val Ala Ile 
    450                 455                 460                 


Ala Ser Asn Asn Gly Gly Lys Gln Ala Leu Glu Thr Val Gln Arg Leu 
465                 470                 475                 480 


Leu Pro Val Leu Cys Gln Asp His Gly Leu Thr Pro Asp Gln Val Val 
                485                 490                 495     


Ala Ile Ala Ser Asn Gly Gly Gly Lys Gln Ala Leu Glu Thr Val Gln 
            500                 505                 510         


Arg Leu Leu Pro Val Leu Cys Gln Asp His Gly Leu Thr Pro Asp Gln 
        515                 520                 525             


Val Val Ala Ile Ala Ser Asn Ile Gly Gly Lys Gln Ala Leu Glu Ser 
    530                 535                 540                 


Ile Val Ala Gln Leu Ser Arg Pro Asp Pro Ala Leu Ala Ala Leu Thr 
545                 550                 555                 560 


Asn Asp His Leu Val Ala Leu Ala Cys Leu Gly Gly Arg Pro Ala Met 
                565                 570                 575     


Asp Ala Val Lys Lys Gly Leu Pro His Ala Pro Glu Leu Ile Arg Arg 
            580                 585                 590         


Val Asn Arg Arg Ile Gly Glu Arg Thr Ser His Arg Val Ala Ile Ser 
        595                 600                 605             


Arg Val Gly Gly Ser Ser Arg Arg Glu Ser Ile Asn Pro Trp Ile Leu 
    610                 615                 620                 


Thr Gly Phe Ala Asp Ala Glu Gly Cys Phe Arg Leu Asp Ile Arg Asn 
625                 630                 635                 640 


Ala Asn Asp Leu Arg Ala Gly Tyr Arg Thr Arg Leu Ala Phe Glu Ile 
                645                 650                 655     


Val Leu His Asn Lys Asp Lys Ser Ile Leu Glu Asn Ile Gln Ser Thr 
            660                 665                 670         


Trp Lys Val Gly Thr Ile Tyr Asn Ala Gly Asp Asn Ala Val Arg Leu 
        675                 680                 685             


Gln Val Thr Arg Phe Glu Asp Leu Lys Val Ile Ile Gly His Phe Glu 
    690                 695                 700                 


Lys Tyr Pro Leu Ile Thr Gln Lys Leu Gly Asp Tyr Lys Leu Phe Lys 
705                 710                 715                 720 


Gln Ala Phe Ser Val Met Glu Asn Lys Glu His Leu Lys Glu Asn Gly 
                725                 730                 735     


Ile Lys Glu Leu Val Arg Ile Lys Ala Lys Met Asn Trp Gly Leu Asn 
            740                 745                 750         


Asp Glu Leu Lys Lys Ala Phe Pro Glu Asn Ile Ser Lys Glu Arg Pro 
        755                 760                 765             


Leu Ile Asn Lys Asn Ile Pro Asn Leu Lys Trp Leu Ala Gly Phe Thr 
    770                 775                 780                 


Ser Gly Asp Gly Ser Phe Met Val Glu Leu Met Lys Asn Lys Asn Asn 
785                 790                 795                 800 


Val Ile Val Arg Val Arg Leu Arg Phe Ser Ile Ser Gln His Ile Arg 
                805                 810                 815     


Asp Lys Asn Leu Met Asn Ser Leu Ile Thr Tyr Leu Gly Cys Gly Arg 
            820                 825                 830         


Ile Val Glu Asn Asn Lys Ser Glu His Ser Trp Leu Glu Phe Ile Val 
        835                 840                 845             


Thr Lys Phe Ser Asp Ile Asn Asp Lys Ile Ile Pro Val Phe Gln Glu 
    850                 855                 860                 


Asn Thr Leu Ile Gly Val Lys Leu Glu Asp Phe Glu Asp Trp Cys Lys 
865                 870                 875                 880 


Val Ala Lys Leu Ile Glu Glu Lys Lys His Leu Thr Glu Ser Gly Leu 
                885                 890                 895     


Asp Glu Ile Lys Lys Ile Lys Leu Asn Met Asn Lys Gly Arg Val Phe 
            900                 905                 910         


Ser Gly Arg 
        915 


<210>  20
<211>  22
<212>  DNA
<213>  Homo sapiens

<400>  20
ctgtaagata ttcccatccc ca                                                22


<210>  21
<211>  13
<212>  DNA
<213>  Homo sapiens

<400>  21
ttgttatgag gta                                                          13


<210>  22
<211>  39
<212>  DNA
<213>  Homo sapiens

<400>  22
ttgttatgag gtatggtctg taagatattc ccatcccca                              39


<210>  23
<211>  22
<212>  DNA
<213>  Homo sapiens

<400>  23
ctgtaagata ttcaaccttt ta                                                22


<210>  24
<211>  22
<212>  DNA
<213>  Homo sapiens

<400>  24
tttccactta ttcccatccc ca                                                22


<210>  25
<211>  22
<212>  DNA
<213>  Homo sapiens

<400>  25
ctgtaagata ttctacgtct gc                                                22


<210>  26
<211>  22
<212>  DNA
<213>  Homo sapiens

<400>  26
cttccaggaa ttcccatccc ca                                                22


<210>  27
<211>  22
<212>  DNA
<213>  Homo sapiens

<400>  27
ctgtaagata ttccacaggc tc                                                22


<210>  28
<211>  22
<212>  DNA
<213>  Homo sapiens

<400>  28
tgtccaataa ttcccatccc ca                                                22


<210>  29
<211>  22
<212>  DNA
<213>  Homo sapiens

<400>  29
ctgtaagata ttcaccgatt tt                                                22


<210>  30
<211>  7244
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Made in Lab - synthesized I-OnuI variant CBLB.E3 surface display 
       plasmid

<400>  30
gacgaaaggg cctcgtgata cgcctatttt tataggttaa tgtcatgata ataatggttt       60

cttaggacgg atcgcttgcc tgtaacttac acgcgcctcg tatcttttaa tgatggaata      120

atttgggaat ttactctgtg tttatttatt tttatgtttt gtatttggat tttagaaagt      180

aaataaagaa ggtagaagag ttacggaatg aagaaaaaaa aataaacaaa ggtttaaaaa      240

atttcaacaa aaagcgtact ttacatatat atttattaga caagaaaagc agattaaata      300

gatatacatt cgattaacga taagtaaaat gtaaaatcac aggattttcg tgtgtggtct      360

tctacacaga caagatgaaa caattcggca ttaatacctg agagcaggaa gagcaagata      420

aaaggtagta tttgttggcg atccccctag agtcttttac atcttcggaa aacaaaaact      480

attttttctt taatttcttt ttttactttc tatttttaat ttatatattt atattaaaaa      540

atttaaatta taattatttt tatagcacgt gatgaaaagg acccaggtgg cacttttcgg      600

ggaaatgtgc gcggaacccc tatttgttta tttttctaaa tacattcaaa tatgtatccg      660

ctcatgagac aataaccctg ataaatgctt caataatatt gaaaaaggaa gagtatgagt      720

attcaacatt tccgtgtcgc ccttattccc ttttttgcgg cattttgcct tcctgttttt      780

gctcacccag aaacgctggt gaaagtaaaa gatgctgaag atcagttggg tgcacgagtg      840

ggttacatcg aactggatct caacagcggt aagatccttg agagttttcg ccccgaagaa      900

cgttttccaa tgatgagcac ttttaaagtt ctgctatgtg gcgcggtatt atcccgtatt      960

gacgccgggc aagagcaact cggtcgccgc atacactatt ctcagaatga cttggttgag     1020

tactcaccag tcacagaaaa gcatcttacg gatggcatga cagtaagaga attatgcagt     1080

gctgccataa ccatgagtga taacactgcg gccaacttac ttctgacaac gatcggagga     1140

ccgaaggagc taaccgcttt ttttcacaac atgggggatc atgtaactcg ccttgatcgt     1200

tgggaaccgg agctgaatga agccatacca aacgacgagc gtgacaccac gatgcctgta     1260

gcaatggcaa caacgttgcg caaactatta actggcgaac tacttactct agcttcccgg     1320

caacaattaa tagactggat ggaggcggat aaagttgcag gaccacttct gcgctcggcc     1380

cttccggctg gctggtttat tgctgataaa tctggagccg gtgagcgtgg gtctcgcggt     1440

atcattgcag cactggggcc agatggtaag ccctcccgta tcgtagttat ctacacgacg     1500

ggcagtcagg caactatgga tgaacgaaat agacagatcg ctgagatagg tgcctcactg     1560

attaagcatt ggtaactgtc agaccaagtt tactcatata tactttagat tgatttaaaa     1620

cttcattttt aatttaaaag gatctaggtg aagatccttt ttgataatct catgaccaaa     1680

atcccttaac gtgagttttc gttccactga gcgtcagacc ccgtagaaaa gatcaaagga     1740

tcttcttgag atcctttttt tctgcgcgta atctgctgct tgcaaacaaa aaaaccaccg     1800

ctaccagcgg tggtttgttt gccggatcaa gagctaccaa ctctttttcc gaaggtaact     1860

ggcttcagca gagcgcagat accaaatact gtccttctag tgtagccgta gttaggccac     1920

cacttcaaga actctgtagc accgcctaca tacctcgctc tgctaatcct gttaccagtg     1980

gctgctgcca gtggcgataa gtcgtgtctt accgggttgg actcaagacg atagttaccg     2040

gataaggcgc agcggtcggg ctgaacgggg ggttcgtgca cacagcccag cttggagcga     2100

acgacctaca ccgaactgag atacctacag cgtgagcatt gagaaagcgc cacgcttccc     2160

gaagggagaa aggcggacag gtatccggta agcggcaggg tcggaacagg agagcgcacg     2220

agggagcttc caggggggaa cgcctggtat ctttatagtc ctgtcgggtt tcgccacctc     2280

tgacttgagc gtcgattttt gtgatgctcg tcaggggggc cgagcctatg gaaaaacgcc     2340

agcaacgcgg cctttttacg gttcctggcc ttttgctggc cttttgctca catgttcttt     2400

cctgcgttat cccctgattc tgtggataac cgtattaccg cctttgagtg agctgatacc     2460

gctcgccgca gccgaacgac cgagcgcagc gagtcagtga gcgaggaagc ggaagagcgc     2520

ccaatacgca aaccgcctct ccccgcgcgt tggccgattc attaatgcag ctggcacgac     2580

aggtttcccg actggaaagc gggcagtgag cgcaacgcaa ttaatgtgag ttacctcact     2640

cattaggcac cccaggcttt acactttatg cttccggctc ctatgttgtg tggaattgtg     2700

agcggataac aatttcacac aggaaacagc tatgaccatg attacgccaa gctcggaatt     2760

aaccctcact aaagggaaca aaagctgggt acccgacagg ttatcagcaa caacacagtc     2820

atatccattc tcaattagct ctaccacagt gtgtgaacca atgtatccag caccacctgt     2880

aaccaaaaca attttagaag tactttcact ttgtaactga gctgtcattt atattgaatt     2940

ttcaaaaatt cttacttttt ttttggatgg acgcaaagaa gtttaataat catattacat     3000

ggcattacca ccatatacat atccatatac atatccatat ctaatcttac ttatatgttg     3060

tggaaatgta aagagcccca ttatcttagc ctaaaaaaac cttctctttg gaactttcag     3120

taatacgctt aactgctcat tgctatattg aagtacggat tagaagccgc cgagcgggtg     3180

acagccctcc gaaggaagac tctcctccgt gcgtcctcgt cttcaccggt cgcgttcctg     3240

aaacgcagat gtgcctcgcg ccgcactgct ccgaacaata aagattctac aatactagct     3300

tttatggtta tgaagaggaa aaattggcag taacctggcc ccacaaacct tcaaatgaac     3360

gaatcaaatt aacaaccata ggatgataat gcgattagtt ttttagcctt atttctgggg     3420

taattaatca gcgaagcgat gatttttgat ctattaacag atatataaat gcaaaaactg     3480

cataaccact ttaactaata ctttcaacat tttcggtttg tattacttct tattcaaatg     3540

taataaaaga tcgaatccta cttcatacat tttcaattaa gatgcagtta cttcgctgtt     3600

tttcaatatt ttctgttatt gcttcagttt tagcacagga actgacaact atatgcgagc     3660

aaatcccctc accaacttta gaatcgacgc cgtactcttt gtcaacgact actattttgg     3720

ccaacgggaa ggcaatgcaa ggagtttttg aatattacaa atcagtaacg tttgtcagta     3780

attgcggttc tcacccctca acaactagca aaggcagccc cataaacaca cagtatgttt     3840

ttaaggacaa tagctcgacg attgaaggta gatacccata cgacgttcca gactacgctc     3900

tgcaggctag tggtggagga ggctctggtg gaggcggtag cggaggcgga gggtcggcta     3960

gctccatcaa cccatggatt ctgactggtt tcgctgatgc cgaaggatgc ttccgactag     4020

acatccgcaa cgcaaacgat ttaagagccg gatacagaac tagactggcc ttcgaaatcg     4080

tactgcacaa caaggacaaa tcgattctgg agaatatcca gtcgacttgg aaggtcggca     4140

caatctacaa cgcgggcgac aacgcagtca gactgcaagt cacacgtttc gaagatttga     4200

aagtgattat cgaccacttc gagaaatatc cgctgataac acagaaattg ggcgattaca     4260

agttgtttaa acaggcattc agcgtcatgg agaacaaaga acatcttaag gagaatggga     4320

ttaaggagct cgtacgaatc aaagctaaga tgaattgggg tctcaatgac gaattgaaaa     4380

aagcatttcc agagaacatt agcaaagagc gctcccttat caataagaac attccgaatc     4440

tcaaatggct ggctggattc acatctggtg acggctcgtt cgtggtggaa ctaaagaaga     4500

gaagaagccc cgtcaaggta ggagtgcggc tgcgattcag catcacccag cacatcagag     4560

acaagaacct gatgaattca ttgataacat acctaggctg tggtcgtatc gttgagaata     4620

acaaatctga gcacagttgg ctcgaattca ttgtaacaaa attcagcgat atcaacgaca     4680

agatcattcc ggtattccag gaaaatactc tgattggcgt caaactcgag gactttgaag     4740

attggtgcaa ggttgccaaa ttgatcgaag agaagaaaca cctgaccgaa tccggtttgg     4800

atgagattaa gaaaatcaag ctgaacatga acaaaggtcg tgtcttctct agaggcggtt     4860

ccagaagcgg atctggtact ggcgaacaga aactcataag cgaagaagac cttagcggga     4920

ctggagagca aaagttgatt tctgaggagg atttgtcggg aaccggggag cagaagttaa     4980

tcagtgaaga ggatctcagt ggaacgggcg aacaaaagtt gatctcggag gaagacttat     5040

aatgaagatc tgataacaac agtgtagatg taacaaaatc gactttgttc ccactgtact     5100

tttagctcgt acaaaataca atatactttt catttctccg taaacaacat gttttcccat     5160

gtaatatcct tttctatttt tcgttccgtt accaacttta cacatacttt atatagctat     5220

tcacttctat acactaaaaa actaagacaa ttttaatttt gctgcctgcc atatttcaat     5280

ttgttataaa ttcctataat ttatcctatt agtagctaaa aaaagatgaa tgtgaatcga     5340

atcctaagag aattgagctc caattcgccc tatagtgagt cgtattacaa ttcactggcc     5400

gtcgttttac aacgtcgtga ctgggaaaac cctggcgtta cccaacttaa tcgccttgca     5460

gcacatcccc ctttcgccag ctggcgtaat agcgaagagg cccgcaccga tcgcctttcc     5520

caacagttgc gcagcctgaa tggcgaatgg acgcgccctg tagcggcgca ttaagcgcgg     5580

cgggtgtggt ggttacgcgc agcgtgaccg ctacacttgc cagcgcccta gcgcccgctc     5640

ctttcgcttt cttcccttcc tttctcgcca cgttcgccgg ctttccccgt caagctctaa     5700

atcgggggct ccctttaggg ttccgattta gtgctttacg gcacctcgac cccaaaaaac     5760

ttgattaggg tgatggttca cgtagtgggc catcgccctg atagacggtt tttcgccctt     5820

tgacgttgga gtccacgttc tttaatagtg gactcttgtt ccaaactgga acaacactca     5880

accctatctc ggtctattct tttgatttat aagggatttt gccgatttcg gcctattggt     5940

taaaaaatga gctgatttaa caaaaattta acgcgaattt taacaaaata ttaacgttta     6000

caatttcctg atgcggtatt ttctccttac gcatctgtgc ggtatttcac accgcaggca     6060

agtgcacaaa caatacttaa ataaatacta ctcagtaata acctatttct tagcattttt     6120

gacgaaattt gctattttgt tagagtcttt tacaccattt gtctccacac ctccgcttac     6180

atcaacacca ataacgccat ttaatctaag cgcatcacca acattttctg gcgtcagtcc     6240

accagctaac ataaaatgta agctttcggg gctctcttgc cttccaaccc agtcagaaat     6300

cgagttccaa tccaaaagtt cacctgtccc acctgcttct gaatcaaaca agggaataaa     6360

cgaatgaggt ttctgtgaag ctgcactgag tagtatgttg cagtcttttg gaaatacgag     6420

tcttttaata actggcaaac cgaggaactc ttggtattct tgccacgact catctccatg     6480

cagttggacg acatcaatgc cgtaatcatt gaccagagcc aaaacatcct ccttaggttg     6540

attacgaaac acgccaacca agtatttcgg agtgcctgaa ctatttttat atgcttttac     6600

aagacttgaa attttccttg caataaccgg gtcaattgtt ctctttctat tgggcacaca     6660

tataataccc agcaagtcag catcggaatc aagagcacat tctgcggcct ctgtgctctg     6720

caagccgcaa actttcacca atggaccaga actacctgtg aaattaataa cagacatact     6780

ccaagctgcc tttgtgtgct taatcacgta tactcacgtg ctcaatagtc accaatgccc     6840

tccctcttgg ccctctcctt ttcttttttc gaccgaatta attcttaatc ggcaaaaaaa     6900

gaaaagctcc ggatcaagat tgtacgtaag gtgacaagct atttttcaat aaagaatatc     6960

ttccactact gccatctggc gtcataactg caaagtacac atatattacg atgctgtcta     7020

ttaaatgctt cctatattat atatatagta atgtcgttta tggtgcactc tcagtacaat     7080

ctgctctgat gccgcatagt taagccagcc ccgacacccg ccaacacccg ctgacgcgcc     7140

ctgacgggct tgtctgctcc cggcatccgc ttacagacaa gctgtgaccg tctccgggag     7200

ctgcatgtgt cagaggtttt caccgtcatc accgaaacgc gcga                      7244


<210>  31
<211>  2751
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Made in Lab - synthesized megaTAL CBLB.E3 mRNA

<400>  31
augggauccu gcaggccacc uaagaagaaa cgcaaagucg uggaucuacg cacgcucggc       60

uacagucagc agcagcaaga gaagaucaaa ccgaaggugc guucgacagu ggcgcagcac      120

cacgaggcac uggugggcca uggguuuaca cacgcgcaca ucguugcgcu cagccaacac      180

ccggcagcgu uagggaccgu cgcugucacg uaucagcaca uaaucacggc guugccagag      240

gcgacacacg aagacaucgu uggcgucggc aaacaguggu ccggcgcacg cgcccuggag      300

gccuugcuca cggaugcggg ggaguugaga gguccgccgu uacaguugga cacaggccaa      360

cuugugaaga uugcaaaacg uggcggcgug accgcaaugg aggcagugca ugcaucgcgc      420

aaugcacuga cgggugcccc ccugaacuua acacccgauc aagugguagc gauagcguca      480

aacggcgggg guaaacaggc uuuggagacg guacagcggu uauugccggu acucugccag      540

gaccacggau ugacaccgga ccaaguggug gcgauugcgu ccaacaacgg aggcaagcag      600

gcacuagaga cuguccaacg gcuucuuccc guucuuuguc aggaucaugg gcuaaccccu      660

gaucagguag ucgcuauagc uucaaaugga gggggcaagc aagcacugga gacuguucaa      720

cgacuccugc cagugcucug ccaagaccac ggacuuacac cagaucaagu gguugcuauu      780

gccuccaaug guggcgggaa acaagcguug gaaacugugc agagacuguu accugucuug      840

ugucaagacc acggccucac gccagaucag gugguagcca uagcgucgaa cauugguggu      900

aagcaagccc uugaaacggu ccagcgucuu cugccggugu ugugccagga ccacggacua      960

acgccggauc aggucguagc cauugcuuca aaugggggcg gcaaacaggc gcuagagaca     1020

guccagcgcc ucuugccugu guuaugccag gaucacggcu uaaccccaga ccaaguugug     1080

gcuauugcau cuaacaaugg uggcaaacaa gccuuggaga cagugcaacg auuacugccu     1140

gucuuauguc aggaucaugg ccugacgccc gaucagguag uggcaaucgc aucuaacauu     1200

ggagguaagc aagcacugga gacuguccag agauuguuac ccguacuaug ucaagaucau     1260

gguuugacgc cugaucaggu uguugcgaua gccagcaaua acggagggaa acaggcucuu     1320

gaaaccguac agcgacuucu cccagucuug ugccaagauc acgggcuuac uccugaucaa     1380

gucguagcua ucgccagcaa uaacggugga aaacaggccc uggaaaccgu acaacgucuc     1440

cucccaguac uuugucaaga ccacggguug acuccggauc aagucgucgc gaucgcgagc     1500

aauggugggg ggaagcaggc gcuggaaacu guucagagac ugcugccugu acuuugucag     1560

gaccaugguc ugacaccuga ccaaguugug gcgauagcca guaauaucgg gggaaaacag     1620

gcacuagaga gcauuguggc ccagcugagc cggccugauc cggcguuggc cgcguugacc     1680

aacgaccacc ucgucgccuu ggccugccuc ggcggacguc cugccaugga ugcagugaaa     1740

aagggauugc cgcacgcgcc ggaauugauc agaagaguca aucgccguau uggcgaacgc     1800

acgucccauc gcguugcgau aucuagagug ggaggaagcu cgcgcagaga guccaucaac     1860

ccauggauuc ugacugguuu cgcugaugcc gaaggaugcu uccgacuaga cauccgcaac     1920

gcaaacgauu uaagagccgg auacagaacu agacuggccu ucgaaaucgu acugcacaac     1980

aaggacaaau cgauucugga gaauauccag ucgacuugga aggucggcac aaucuacaac     2040

gcgggcgaca acgcagucag acugcaaguc acacguuucg aagauuugaa agugauuauc     2100

gaccacuucg agaaauaucc gcugauaaca cagaaauugg gcgauuacaa guuguuuaaa     2160

caggcauuca gcgucaugga gaacaaagaa caucuuaagg agaaugggau uaaggagcuc     2220

guacgaauca aagcuaagau gaauuggggu cucaaugacg aauugaaaaa agcauuucca     2280

gagaacauua gcaaagagcg cucccuuauc aauaagaaca uuccgaaucu caaauggcug     2340

gcuggauuca caucugguga cggcucguuc gugguggaac uaaagaagag aagaagcccc     2400

gucaagguag gagugcggcu gcgauucagc aucacccagc acaucagaga caagaaccug     2460

augaauucau ugauaacaua ccuaggcugu ggucguaucg uugagaauaa caaaucugag     2520

cacaguuggc ucgaauucau uguaacaaaa uucagcgaua ucaacgacaa gaucauuccg     2580

guauuccagg aaaauacucu gauuggcguc aaacucgagg acuuugaaga uuggugcaag     2640

guugccaaau ugaucgaaga gaagaaacac cugaccgaau ccgguuugga ugagauuaag     2700

aaaaucaagc ugaacaugaa caaaggucgu gucuucagcg gccgcugaua a              2751


<210>  32
<211>  2751
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Made in Lab - synthesized megaTAL CBLB.A8 mRNA

<400>  32
augggauccu gcaggccacc uaagaagaaa cgcaaagucg uggaucuacg cacgcucggc       60

uacagucagc agcagcaaga gaagaucaaa ccgaaggugc guucgacagu ggcgcagcac      120

cacgaggcac uggugggcca uggguuuaca cacgcgcaca ucguugcgcu cagccaacac      180

ccggcagcgu uagggaccgu cgcugucacg uaucagcaca uaaucacggc guugccagag      240

gcgacacacg aagacaucgu uggcgucggc aaacaguggu ccggcgcacg cgcccuggag      300

gccuugcuca cggaugcggg ggaguugaga gguccgccgu uacaguugga cacaggccaa      360

cuugugaaga uugcaaaacg uggcggcgug accgcaaugg aggcagugca ugcaucgcgc      420

aaugcacuga cgggugcccc ccugaacuua acacccgauc aagugguagc gauagcguca      480

aacggcgggg guaaacaggc uuuggagacg guacagcggu uauugccggu acucugccag      540

gaccacggau ugacaccgga ccaaguggug gcgauugcgu ccaacaacgg aggcaagcag      600

gcacuagaga cuguccaacg gcuucuuccc guucuuuguc aggaucaugg gcuaaccccu      660

gaucagguag ucgcuauagc uucaaaugga gggggcaagc aagcacugga gacuguucaa      720

cgacuccugc cagugcucug ccaagaccac ggacuuacac cagaucaagu gguugcuauu      780

gccuccaaug guggcgggaa acaagcguug gaaacugugc agagacuguu accugucuug      840

ugucaagacc acggccucac gccagaucag gugguagcca uagcgucgaa cauugguggu      900

aagcaagccc uugaaacggu ccagcgucuu cugccggugu ugugccagga ccacggacua      960

acgccggauc aggucguagc cauugcuuca aaugggggcg gcaaacaggc gcuagagaca     1020

guccagcgcc ucuugccugu guuaugccag gaucacggcu uaaccccaga ccaaguugug     1080

gcuauugcau cuaacaaugg uggcaaacaa gccuuggaga cagugcaacg auuacugccu     1140

gucuuauguc aggaucaugg ccugacgccc gaucagguag uggcaaucgc aucuaacauu     1200

ggagguaagc aagcacugga gacuguccag agauuguuac ccguacuaug ucaagaucau     1260

gguuugacgc cugaucaggu uguugcgaua gccagcaaua acggagggaa acaggcucuu     1320

gaaaccguac agcgacuucu cccagucuug ugccaagauc acgggcuuac uccugaucaa     1380

gucguagcua ucgccagcaa uaacggugga aaacaggccc uggaaaccgu acaacgucuc     1440

cucccaguac uuugucaaga ccacggguug acuccggauc aagucgucgc gaucgcgagc     1500

aauggugggg ggaagcaggc gcuggaaacu guucagagac ugcugccugu acuuugucag     1560

gaccaugguc ugacaccuga ccaaguugug gcgauagcca guaauaucgg gggaaaacag     1620

gcacuagaga gcauuguggc ccagcugagc cggccugauc cggcguuggc cgcguugacc     1680

aacgaccacc ucgucgccuu ggccugccuc ggcggacguc cugccaugga ugcagugaaa     1740

aagggauugc cgcacgcgcc ggaauugauc agaagaguca aucgccguau uggcgaacgc     1800

acgucccauc gcguugcgau aucuagagug ggaggaagcu cgcgcagaga guccaucaac     1860

ccauggauuc ugacugguuu cgcugaugcc gaaggaugcu uccgacuaga cauccgcaac     1920

gcaaacgauu uaagagccgg auacagaacu agacuggccu ucgaaaucgu acugcacaac     1980

aaggacaaau cgauucugga gaauauccag ucgacuugga aggucggcac aaucuacaac     2040

gcgggcgaca acgcagucag acugcaaguc acacguuucg aagauuugaa agugauuauc     2100

ggccacuucg agaaauaucc gcugauaaca cagaaauugg gcgauuacaa guuguuuaaa     2160

caggcauuca gcgucaugga gaacaaagaa caucuuaagg agaaugggau uaaggagcuc     2220

guacgaauca aagcuaagau gaauuggggu cucaaugacg aauugaaaaa agcauuucca     2280

gagaacauua gcaaagagcg cccccuuauc aauaagaaca ucccaaaucu caaauggcug     2340

gcuggauuca caucugguga cggcucguuc augguggaac uaaugaagaa uaagaauaac     2400

guuauuguac gugugcgucu gagauucuca aucucccagc acaucagaga caagaaccug     2460

augaauucau ugauaacaua ccuaggcugu ggucguaucg uugagaauaa caaaucugag     2520

cacaguuggc ucgaauucau uguaacaaaa uucagcgaua ucaacgacaa gaucauuccg     2580

guauuccagg aaaauacucu gauuggcguc aaacucgagg acuuugaaga uuggugcaag     2640

guugccaaau ugaucgaaga gaagaaacac cugaccgaau ccgguuugga ugagauuaag     2700

aaaaucaagc ugaacaugaa caaaggucgu gucuucagcg gccgcugaua a              2751


<210>  33
<211>  2751
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Made in Lab - codon optimized megaTAL CBLB.E3 mRNA

<400>  33
augggauccu gccgcccccc gaaaaagaag cggaaagugg ucgaccuuag aacccuggga       60

uacucccagc agcagcagga aaagauuaag ccgaaggucc ggucaacagu ggcccagcac      120

cacgaggcac uugugggaca cggauuuacc caugcccaua ucgucgcccu uucccagcau      180

ccggcggcuc ugggaaccgu cgccgugacc uaccagcaua uaaucacugc gcugccugaa      240

gcuacccacg aggauauugu gggaguggga aagcagugga gcggagcgag agcgcuggaa      300

gcccuccuga ccgacgcagg agagcuccgg ggaccuccac uccaacucga cacuggacag      360

cuugugaaga uugccaagag aggcggcguc accgcuaugg aggcggugca cgcuucccgg      420

aacgcucuga ccggagcccc ucugaaucug acuccagacc aagucguggc aaucgcaucc      480

aacggcgggg gcaagcaagc ucuggaaaca gugcaacgcc uccugcccgu gcugugccag      540

gaccacggac ucacccccga ucaaguagug gccaucgcuu ccaacaacgg uggaaaacag      600

gcucucgaaa caguccagcg gcuguugcca guccugugcc aagaccacgg guugacgccu      660

gaccaagugg uggccauagc gucgaauggu ggaggcaagc aagccuugga aaccguucag      720

agguugcucc cagugcuuug ccaggaucac ggacugacac cugaccaggu ggucgcaauu      780

gccuccaacg gaggggggaa gcaggcccuc gaaacggugc aacggcugcu gccugugcuc      840

ugucaggacc acggcuugac ccccgaccaa gugguggcca ucgcgagcaa uauuggugga      900

aagcaggccu uggagacugu gcagagacuu cugccggugc ucugccaaga ucauggccuu      960

accccagauc aaguggucgc gaucgcuucg aacggaggcg gcaaacaggc ccuggagacu     1020

gugcaaagac ugcugccggu guugugucag gaucauggau ugacucccga ucagguggug     1080

gcgaucgccu caaauaacgg aggaaaacaa gcccucgaga cuguucagcg gcuacugccc     1140

guccuguguc aggaccaugg cuugacaccc gaccagguag ucgccaucgc guccaacauc     1200

ggcggcaagc aggcacucga aaccgugcag agacugcucc cggugcugug ccaggaccac     1260

ggucugacuc cggaucaggu cguugcuauc gccucgaaca acgggggaaa gcaagcgcuu     1320

gagacugucc aacgccuucu gcccgucuug ugucaagauc acgggcuuac uccggaccag     1380

gucguggcua uugccagcaa caacggcggg aagcaagccc uggaaacugu gcagcgccug     1440

uugccggucu ugugccaaga ccacgggcuc accccggauc aagucgucgc uaucgcaucg     1500

aacgguggag guaaacaagc acuggaaacc guccagaggc ugcuuccggu ccucugucaa     1560

gaccauggcc ucacuccuga ucaagugguc gccauagcca gcaauaucgg ugggaaacag     1620

gcacuggaga gcaucgucgc ccagcuuucc cggccagauc cggcccuggc cgcuuugacg     1680

aacgaccauc ugguggcccu ggcuugccug gggggaaggc cagcgaugga cgccgugaag     1740

aagggacugc cccaugcccc ugagcugauu cggcgaguga acaggcggau cggcgaacgg     1800

accucccacc gcguggcgau cuccagaguc gggggaucgu ccagacgcga guccaucaac     1860

ccauggaucc ucaccggauu cgccgaugca gaaggguguu uccggcugga uaucagaaac     1920

gcgaacgauc uccgugcugg guaccggacc agacuggccu ucgagaucgu gcugcacaac     1980

aaggacaaga gcauucucga aaacauccag ucgaccugga aagugggaac uaucuacaac     2040

gcgggagaua acgcggugcg ccugcaaguc accagguucg aggaucucaa ggugaucauc     2100

gaucacuucg agaaguaccc ucugaucacc caaaagcugg gugauuacaa gcuguucaag     2160

caggcguucu ccgucaugga gaacaaggaa caccucaagg aaaacggcau uaaagagcuc     2220

gugagaauca aggccaagau gaacuggggc cugaacgacg aacucaagaa agccuucccc     2280

gagaacaucu ccaaggagcg gucccugauc aacaagaaca uccccaaccu gaaguggcuc     2340

gcgggcuuca ccagcggaga uggcucguuc guggucgaac ugaagaagag gcggucccca     2400

gugaaggugg gagugcgacu gcgguucucc auuacucagc acauccgcga caagaaccug     2460

augaacucgc ugaucaccua ccuuggaugc ggcagaaucg uggagaauaa caaguccgag     2520

cacuccuggc uggaguucau cgugaccaag uuuucggaua uuaaugacaa gauuauuccg     2580

guguuccagg aaaacacccu gauugguguc aaacuggagg acuuugagga cuggugcaag     2640

guggccaagc uuaucgaaga gaagaagcac cugaccgagu ccgggcugga cgagaucaag     2700

aagaucaagc ugaacaugaa caagggucgc guguucuccg gucgcugaua g              2751


<210>  34
<211>  2751
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Made in Lab - synthesized megaTAL CBLB.D2 mRNA

<400>  34
augggauccu gcaggccacc uaagaagaaa cgcaaagucg uggaucuacg cacgcucggc       60

uacagucagc agcagcaaga gaagaucaaa ccgaaggugc guucgacagu ggcgcagcac      120

cacgaggcac uggugggcca uggguuuaca cacgcgcaca ucguugcgcu cagccaacac      180

ccggcagcgu uagggaccgu cgcugucacg uaucagcaca uaaucacggc guugccagag      240

gcgacacacg aagacaucgu uggcgucggc aaacaguggu ccggcgcacg cgcccuggag      300

gccuugcuca cggaugcggg ggaguugaga gguccgccgu uacaguugga cacaggccaa      360

cuugugaaga uugcaaaacg uggcggcgug accgcaaugg aggcagugca ugcaucgcgc      420

aaugcacuga cgggugcccc ccugaacuua acacccgauc aagugguagc gauagcguca      480

aacggcgggg guaaacaggc uuuggagacg guacagcggu uauugccggu acucugccag      540

gaccacggau ugacaccgga ccaaguggug gcgauugcgu ccaacaacgg aggcaagcag      600

gcacuagaga cuguccaacg gcuucuuccc guucuuuguc aggaucaugg gcuaaccccu      660

gaucagguag ucgcuauagc uucaaaugga gggggcaagc aagcacugga gacuguucaa      720

cgacuccugc cagugcucug ccaagaccac ggacuuacac cagaucaagu gguugcuauu      780

gccuccaaug guggcgggaa acaagcguug gaaacugugc agagacuguu accugucuug      840

ugucaagacc acggccucac gccagaucag gugguagcca uagcgucgaa cauugguggu      900

aagcaagccc uugaaacggu ccagcgucuu cugccggugu ugugccagga ccacggacua      960

acgccggauc aggucguagc cauugcuuca aaugggggcg gcaaacaggc gcuagagaca     1020

guccagcgcc ucuugccugu guuaugccag gaucacggcu uaaccccaga ccaaguugug     1080

gcuauugcau cuaacaaugg uggcaaacaa gccuuggaga cagugcaacg auuacugccu     1140

gucuuauguc aggaucaugg ccugacgccc gaucagguag uggcaaucgc aucuaacauu     1200

ggagguaagc aagcacugga gacuguccag agauuguuac ccguacuaug ucaagaucau     1260

gguuugacgc cugaucaggu uguugcgaua gccagcaaua acggagggaa acaggcucuu     1320

gaaaccguac agcgacuucu cccagucuug ugccaagauc acgggcuuac uccugaucaa     1380

gucguagcua ucgccagcaa uaacggugga aaacaggccc uggaaaccgu acaacgucuc     1440

cucccaguac uuugucaaga ccacggguug acuccggauc aagucgucgc gaucgcgagc     1500

aauggugggg ggaagcaggc gcuggaaacu guucagagac ugcugccugu acuuugucag     1560

gaccaugguc ugacaccuga ccaaguugug gcgauagcca guaauaucgg gggaaaacag     1620

gcacuagaga gcauuguggc ccagcugagc cggccugauc cggcguuggc cgcguugacc     1680

aacgaccacc ucgucgccuu ggccugccuc ggcggacguc cugccaugga ugcagugaaa     1740

aagggauugc cgcacgcgcc ggaauugauc agaagaguca aucgccguau uggcgaacgc     1800

acgucccauc gcguugcgau aucuagagug ggaggaagcu cgcgcagaga guccaucaac     1860

ccauggauuc ugacugguuu cgcugaugcc gaaggaugcu uccgacuaga cauccacaac     1920

gcaaacguau ugaggucugg uuacagaacu agacuguccu ucgaaaucgu acugcacaac     1980

aaggacaaau cgauucugga gaauauccag ucgacuugga aggucggcaa aaucuacaac     2040

gcgggcgaca acgcagucag acugcaaguc acacguuucg aagauuugaa agugauuauc     2100

gaccacuucg agaaauaucc gcugauaaca cagaaauugg gcgauuacaa guuguuuaaa     2160

caggcauuca gcgucaugga gaacaaagaa caucuuaagg agaaugggau uaaggagcuc     2220

guacgaauca aagcuaagau gaauuggggu cucaaugacg aauugaaaaa agcauuucca     2280

gagaacauua gcaaagagcg cccccuuauc aauaagaaca uuccgaaucu caaauggcug     2340

gcuggauuca caucugguga cggcucguuc augguggaac uaaugaagaa uaagaauaac     2400

guuauuguac gugugcgucu gagauucuca aucucccagc acaucagaga caagaaccug     2460

augaauucau ugauaacaua ccuaggcugu ggucguaucg uugagaauaa caaaucugag     2520

cacaguuggc ucgaauucau uguaacaaaa uucagcgaua ucaacgacaa gaucauuccg     2580

guauuccagg aaaauacucu gauuggcguc aaacucgagg acuuugaaga uuggugcaag     2640

guugccaaau ugaucgaaga gaagaaacac cugaccgaau ccgguuugga ugagauuaag     2700

aaaaucaagc ugaacaugaa caaaggucgu gucuucagcg gccgcugaua a              2751


<210>  35
<211>  2751
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Made in Lab - synthesized megaTAL CBLB.B5 mRNA

<400>  35
augggauccu gcaggccacc uaagaagaaa cgcaaagucg uggaucuacg cacgcucggc       60

uacagucagc agcagcaaga gaagaucaaa ccgaaggugc guucgacagu ggcgcagcac      120

cacgaggcac uggugggcca uggguuuaca cacgcgcaca ucguugcgcu cagccaacac      180

ccggcagcgu uagggaccgu cgcugucacg uaucagcaca uaaucacggc guugccagag      240

gcgacacacg aagacaucgu uggcgucggc aaacaguggu ccggcgcacg cgcccuggag      300

gccuugcuca cggaugcggg ggaguugaga gguccgccgu uacaguugga cacaggccaa      360

cuugugaaga uugcaaaacg uggcggcgug accgcaaugg aggcagugca ugcaucgcgc      420

aaugcacuga cgggugcccc ccugaacuua acacccgauc aagugguagc gauagcguca      480

aacggcgggg guaaacaggc uuuggagacg guacagcggu uauugccggu acucugccag      540

gaccacggau ugacaccgga ccaaguggug gcgauugcgu ccaacaacgg aggcaagcag      600

gcacuagaga cuguccaacg gcuucuuccc guucuuuguc aggaucaugg gcuaaccccu      660

gaucagguag ucgcuauagc uucaaaugga gggggcaagc aagcacugga gacuguucaa      720

cgacuccugc cagugcucug ccaagaccac ggacuuacac cagaucaagu gguugcuauu      780

gccuccaaug guggcgggaa acaagcguug gaaacugugc agagacuguu accugucuug      840

ugucaagacc acggccucac gccagaucag gugguagcca uagcgucgaa cauugguggu      900

aagcaagccc uugaaacggu ccagcgucuu cugccggugu ugugccagga ccacggacua      960

acgccggauc aggucguagc cauugcuuca aaugggggcg gcaaacaggc gcuagagaca     1020

guccagcgcc ucuugccugu guuaugccag gaucacggcu uaaccccaga ccaaguugug     1080

gcuauugcau cuaacaaugg uggcaaacaa gccuuggaga cagugcaacg auuacugccu     1140

gucuuauguc aggaucaugg ccugacgccc gaucagguag uggcaaucgc aucuaacauu     1200

ggagguaagc aagcacugga gacuguccag agauuguuac ccguacuaug ucaagaucau     1260

gguuugacgc cugaucaggu uguugcgaua gccagcaaua acggagggaa acaggcucuu     1320

gaaaccguac agcgacuucu cccagucuug ugccaagauc acgggcuuac uccugaucaa     1380

gucguagcua ucgccagcaa uaacggugga aaacaggccc uggaaaccgu acaacgucuc     1440

cucccaguac uuugucaaga ccacggguug acuccggauc aagucgucgc gaucgcgagc     1500

aauggugggg ggaagcaggc gcuggaaacu guucagagac ugcugccugu acuuugucag     1560

gaccaugguc ugacaccuga ccaaguugug gcgauagcca guaauaucgg gggaaaacag     1620

gcacuagaga gcauuguggc ccagcugagc cggccugauc cggcguuggc cgcguugacc     1680

aacgaccacc ucgucgccuu ggccugccuc ggcggacguc cugccaugga ugcagugaaa     1740

aagggauugc cgcacgcgcc ggaauugauc agaagaguca aucgccguau uggcgaacgc     1800

acgucccauc gcguugcgau aucuagagug ggaggaagcu cgcgcagaga guccaucaac     1860

ccauggauuc ugacugguuu cgcugaugcc gaaggaugcu uccgacuaga cauccacaac     1920

gcaaacguau ugaggucugg uuacagaacu agacuguccu ucgaaaucgu acugcacaac     1980

aaggacaaau cgauucugga gaauauccag ucgacuugga aggucggcac aaucuacaac     2040

gcgggcgaca acgcagucag acugcaaguc acacguuucg aagauuugaa agugauuauc     2100

gaccacuucg agaaauaucc gcugauaaca cagaaauugg gcgauuacaa guuguuuaaa     2160

caggcauuca gccucaugga gaacaaagaa caucuuaagg agaaugggau uaaggagcuc     2220

guacgaauca aagcuaagau gaauuggggu cucaaugacg aauugaaaaa agcauuucca     2280

gagaacauua gcaaagagcg cccccuuauc aauaagaaca uuccgaaucu caaauggcug     2340

gcuggauuca caucugguga cggcucguuc gugguggaac uaaagaagag aagaagcccc     2400

gucaagguag gagugcggcu gcgauucggc aucacccagc acaucagaga caagaaccug     2460

augaauucau ugauaacaua ccuaggcugu ggucguaucg uugagaauaa caaaucugag     2520

cacaguuggc ucgaauucau uguaacaaaa uucagcgaua ucaacgacaa gaucauuccg     2580

guauuccagg aaaauacucu gauuggcguc aaacucgagg acuuugaaga uuggugcaag     2640

guugccaaau ugaucgaaga gaagaaacac cugaccgaau ccgguuugga ugagauuaag     2700

aaaaucaagc ugaacaugaa caaaggucgu gucuucagcg gccgcugaua a              2751


<210>  36
<211>  2751
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Made in Lab - synthesized megaTAL CBLB.F6 mRNA

<400>  36
augggauccu gcaggccacc uaagaagaaa cgcaaagucg uggaucuacg cacgcucggc       60

uacagucagc agcagcaaga gaagaucaaa ccgaaggugc guucgacagu ggcgcagcac      120

cacgaggcac uggugggcca uggguuuaca cacgcgcaca ucguugcgcu cagccaacac      180

ccggcagcgu uagggaccgu cgcugucacg uaucagcaca uaaucacggc guugccagag      240

gcgacacacg aagacaucgu uggcgucggc aaacaguggu ccggcgcacg cgcccuggag      300

gccuugcuca cggaugcggg ggaguugaga gguccgccgu uacaguugga cacaggccaa      360

cuugugaaga uugcaaaacg uggcggcgug accgcaaugg aggcagugca ugcaucgcgc      420

aaugcacuga cgggugcccc ccugaacuua acacccgauc aagugguagc gauagcguca      480

aacggcgggg guaaacaggc uuuggagacg guacagcggu uauugccggu acucugccag      540

gaccacggau ugacaccgga ccaaguggug gcgauugcgu ccaacaacgg aggcaagcag      600

gcacuagaga cuguccaacg gcuucuuccc guucuuuguc aggaucaugg gcuaaccccu      660

gaucagguag ucgcuauagc uucaaaugga gggggcaagc aagcacugga gacuguucaa      720

cgacuccugc cagugcucug ccaagaccac ggacuuacac cagaucaagu gguugcuauu      780

gccuccaaug guggcgggaa acaagcguug gaaacugugc agagacuguu accugucuug      840

ugucaagacc acggccucac gccagaucag gugguagcca uagcgucgaa cauugguggu      900

aagcaagccc uugaaacggu ccagcgucuu cugccggugu ugugccagga ccacggacua      960

acgccggauc aggucguagc cauugcuuca aaugggggcg gcaaacaggc gcuagagaca     1020

guccagcgcc ucuugccugu guuaugccag gaucacggcu uaaccccaga ccaaguugug     1080

gcuauugcau cuaacaaugg uggcaaacaa gccuuggaga cagugcaacg auuacugccu     1140

gucuuauguc aggaucaugg ccugacgccc gaucagguag uggcaaucgc aucuaacauu     1200

ggagguaagc aagcacugga gacuguccag agauuguuac ccguacuaug ucaagaucau     1260

gguuugacgc cugaucaggu uguugcgaua gccagcaaua acggagggaa acaggcucuu     1320

gaaaccguac agcgacuucu cccagucuug ugccaagauc acgggcuuac uccugaucaa     1380

gucguagcua ucgccagcaa uaacggugga aaacaggccc uggaaaccgu acaacgucuc     1440

cucccaguac uuugucaaga ccacggguug acuccggauc aagucgucgc gaucgcgagc     1500

aauggugggg ggaagcaggc gcuggaaacu guucagagac ugcugccugu acuuugucag     1560

gaccaugguc ugacaccuga ccaaguugug gcgauagcca guaauaucgg gggaaaacag     1620

gcacuagaga gcauuguggc ccagcugagc cggccugauc cggcguuggc cgcguugacc     1680

aacgaccacc ucgucgccuu ggccugccuc ggcggacguc cugccaugga ugcagugaaa     1740

aagggauugc cgcacgcgcc ggaauugauc agaagaguca aucgccguau uggcgaacgc     1800

acgucccauc gcguugcgau aucuagagug ggaggaagcu cgcgcagaga guccaucaac     1860

ccauggauuc ugacugguuu cgcugaugcc gaaggaugcu uccgacuaga cauccgcaac     1920

gcaaacgauu uaagagccgg auacagaacu agacuggccu ucgaaaucgu acugcacaac     1980

aaggacaaau cgauucugga gaauauccag ucgacuugga aggucggcac aaucuacaac     2040

gcgggcgaca acgcagucag acugcaaguc acacguuucg aagauuugaa agugauuauc     2100

gaccacuucg agaaauaucc gcugauaaca cagaaauugg gcgauuacaa guuguuuaaa     2160

caggcauuca gcgucaugga gaacaaagaa caucuuaagg agaaugggau uaaggagcuc     2220

guacgaauca aagcuaagau gaauuggggu cucaaugacg aauugaaaaa agcauuucca     2280

gagaacauua gcaaagagcg cccccuuauc aauaagaaca uuccgaaucu caaauggcug     2340

gcuggauuca caucugguga cggcucguuc augguggaac uaaugaagaa uaagaauaac     2400

guuauuguac gugugcgucu gagauucuca aucucccagc acaucagaga caagaaccug     2460

augaauucau ugauaacaua ccuaggcugu ggucguaucg uugagaauaa caaaucugag     2520

cacaguuggc ucgaauucau uguaacaaaa uucagcgaua ucaacgacaa gaucauuccg     2580

guauuccagg aaaauacucu gauuggcguc aaacucgagg acuuugaaga uuggugcaag     2640

guugccaaau ugaucgaaga gaagaaacac cugaccgaau ccgguuugga ugagauuaag     2700

aaaaucaagc ugaacaugaa caaaggucgu gucuucagcg gccgcugaua a              2751


<210>  37
<211>  711
<212>  RNA
<213>  Mus musculus

<400>  37
augucugagc caccucgggc ugagaccuuu guauuccugg accuagaagc cacugggcuc       60

ccaaacaugg acccugagau ugcagagaua ucccuuuuug cuguucaccg cucuucccug      120

gagaacccag aacgggauga uucugguucc uuggugcugc cccguguucu ggacaagcuc      180

acacugugca ugugcccgga gcgccccuuu acugccaagg ccagugagau uacugguuug      240

agcagcgaaa gccugaugca cugcgggaag gcugguuuca auggcgcugu gguaaggaca      300

cugcagggcu uccuaagccg ccaggagggc cccaucugcc uuguggccca caauggcuuc      360

gauuaugacu ucccacugcu gugcacggag cuacaacguc ugggugccca ucugccccaa      420

gacacugucu gccuggacac acugccugca uugcggggcc uggaccgugc ucacagccac      480

ggcaccaggg cucaaggccg caaaagcuac agccuggcca gucucuucca ccgcuacuuc      540

caggcugaac ccagugcugc ccauucagca gaaggugaug ugcacacccu gcuucugauc      600

uuccugcauc gugcuccuga gcugcucgcc ugggcagaug agcaggcccg cagcugggcu      660

cauauugagc ccauguacgu gccaccugau gguccaagcc ucgaagccug a               711


<210>  38
<211>  236
<212>  PRT
<213>  Mus musculus

<400>  38

Met Ser Glu Pro Pro Arg Ala Glu Thr Phe Val Phe Leu Asp Leu Glu 
1               5                   10                  15      


Ala Thr Gly Leu Pro Asn Met Asp Pro Glu Ile Ala Glu Ile Ser Leu 
            20                  25                  30          


Phe Ala Val His Arg Ser Ser Leu Glu Asn Pro Glu Arg Asp Asp Ser 
        35                  40                  45              


Gly Ser Leu Val Leu Pro Arg Val Leu Asp Lys Leu Thr Leu Cys Met 
    50                  55                  60                  


Cys Pro Glu Arg Pro Phe Thr Ala Lys Ala Ser Glu Ile Thr Gly Leu 
65                  70                  75                  80  


Ser Ser Glu Ser Leu Met His Cys Gly Lys Ala Gly Phe Asn Gly Ala 
                85                  90                  95      


Val Val Arg Thr Leu Gln Gly Phe Leu Ser Arg Gln Glu Gly Pro Ile 
            100                 105                 110         


Cys Leu Val Ala His Asn Gly Phe Asp Tyr Asp Phe Pro Leu Leu Cys 
        115                 120                 125             


Thr Glu Leu Gln Arg Leu Gly Ala His Leu Pro Gln Asp Thr Val Cys 
    130                 135                 140                 


Leu Asp Thr Leu Pro Ala Leu Arg Gly Leu Asp Arg Ala His Ser His 
145                 150                 155                 160 


Gly Thr Arg Ala Gln Gly Arg Lys Ser Tyr Ser Leu Ala Ser Leu Phe 
                165                 170                 175     


His Arg Tyr Phe Gln Ala Glu Pro Ser Ala Ala His Ser Ala Glu Gly 
            180                 185                 190         


Asp Val His Thr Leu Leu Leu Ile Phe Leu His Arg Ala Pro Glu Leu 
        195                 200                 205             


Leu Ala Trp Ala Asp Glu Gln Ala Arg Ser Trp Ala His Ile Glu Pro 
    210                 215                 220                 


Met Tyr Val Pro Pro Asp Gly Pro Ser Leu Glu Ala 
225                 230                 235     


<210>  39
<211>  3
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Exemplary linker sequence

<400>  39

Gly Gly Gly 
1           


<210>  40
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Exemplary linker sequence

<400>  40

Asp Gly Gly Gly Ser 
1               5   


<210>  41
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Exemplary linker sequence

<400>  41

Thr Gly Glu Lys Pro 
1               5   


<210>  42
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Exemplary linker sequence

<400>  42

Gly Gly Arg Arg 
1               


<210>  43
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Exemplary linker sequence

<400>  43

Gly Gly Gly Gly Ser 
1               5   


<210>  44
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Exemplary linker sequence

<400>  44

Glu Gly Lys Ser Ser Gly Ser Gly Ser Glu Ser Lys Val Asp 
1               5                   10                  


<210>  45
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Exemplary linker sequence

<400>  45

Lys Glu Ser Gly Ser Val Ser Ser Glu Gln Leu Ala Gln Phe Arg Ser 
1               5                   10                  15      


Leu Asp 
        


<210>  46
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Exemplary linker sequence

<400>  46

Gly Gly Arg Arg Gly Gly Gly Ser 
1               5               


<210>  47
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Exemplary linker sequence

<400>  47

Leu Arg Gln Arg Asp Gly Glu Arg Pro 
1               5                   


<210>  48
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Exemplary linker sequence

<400>  48

Leu Arg Gln Lys Asp Gly Gly Gly Ser Glu Arg Pro 
1               5                   10          


<210>  49
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Exemplary linker sequence

<400>  49

Leu Arg Gln Lys Asp Gly Gly Gly Ser Gly Gly Gly Ser Glu Arg Pro 
1               5                   10                  15      


<210>  50
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Cleavage sequence by TEV protease


<220>
<221>  misc_feature
<222>  (2)..(3)
<223>  Xaa is any amino acid

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  Xaa is any amino acid

<220>
<221>  MISC_FEATURE
<222>  (7)..(7)
<223>  Xaa = Gly or Ser

<400>  50

Glu Xaa Xaa Tyr Xaa Gln Xaa 
1               5           


<210>  51
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Cleavage sequence by TEV protease

<400>  51

Glu Asn Leu Tyr Phe Gln Gly 
1               5           


<210>  52
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Cleavage sequence by TEV protease

<400>  52

Glu Asn Leu Tyr Phe Gln Ser 
1               5           


<210>  53
<211>  22
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Self-cleaving polypeptide comprising 2A site

<400>  53

Gly Ser Gly Ala Thr Asn Phe Ser Leu Leu Lys Gln Ala Gly Asp Val 
1               5                   10                  15      


Glu Glu Asn Pro Gly Pro 
            20          


<210>  54
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Self-cleaving polypeptide comprising 2A site

<400>  54

Ala Thr Asn Phe Ser Leu Leu Lys Gln Ala Gly Asp Val Glu Glu Asn 
1               5                   10                  15      


Pro Gly Pro 
            


<210>  55
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Self-cleaving polypeptide comprising 2A site

<400>  55

Leu Leu Lys Gln Ala Gly Asp Val Glu Glu Asn Pro Gly Pro 
1               5                   10                  


<210>  56
<211>  21
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Self-cleaving polypeptide comprising 2A site

<400>  56

Gly Ser Gly Glu Gly Arg Gly Ser Leu Leu Thr Cys Gly Asp Val Glu 
1               5                   10                  15      


Glu Asn Pro Gly Pro 
            20      


<210>  57
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Self-cleaving polypeptide comprising 2A site

<400>  57

Glu Gly Arg Gly Ser Leu Leu Thr Cys Gly Asp Val Glu Glu Asn Pro 
1               5                   10                  15      


Gly Pro 
        


<210>  58
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Self-cleaving polypeptide comprising 2A site

<400>  58

Leu Leu Thr Cys Gly Asp Val Glu Glu Asn Pro Gly Pro 
1               5                   10              


<210>  59
<211>  23
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Self-cleaving polypeptide comprising 2A site

<400>  59

Gly Ser Gly Gln Cys Thr Asn Tyr Ala Leu Leu Lys Leu Ala Gly Asp 
1               5                   10                  15      


Val Glu Ser Asn Pro Gly Pro 
            20              


<210>  60
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Self-cleaving polypeptide comprising 2A site

<400>  60

Gln Cys Thr Asn Tyr Ala Leu Leu Lys Leu Ala Gly Asp Val Glu Ser 
1               5                   10                  15      


Asn Pro Gly Pro 
            20  


<210>  61
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Self-cleaving polypeptide comprising 2A site

<400>  61

Leu Leu Lys Leu Ala Gly Asp Val Glu Ser Asn Pro Gly Pro 
1               5                   10                  


<210>  62
<211>  25
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Self-cleaving polypeptide comprising 2A site

<400>  62

Gly Ser Gly Val Lys Gln Thr Leu Asn Phe Asp Leu Leu Lys Leu Ala 
1               5                   10                  15      


Gly Asp Val Glu Ser Asn Pro Gly Pro 
            20                  25  


<210>  63
<211>  22
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Self-cleaving polypeptide comprising 2A site

<400>  63

Val Lys Gln Thr Leu Asn Phe Asp Leu Leu Lys Leu Ala Gly Asp Val 
1               5                   10                  15      


Glu Ser Asn Pro Gly Pro 
            20          


<210>  64
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Self-cleaving polypeptide comprising 2A site

<400>  64

Leu Leu Lys Leu Ala Gly Asp Val Glu Ser Asn Pro Gly Pro 
1               5                   10                  


<210>  65
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Self-cleaving polypeptide comprising 2A site

<400>  65

Leu Leu Asn Phe Asp Leu Leu Lys Leu Ala Gly Asp Val Glu Ser Asn 
1               5                   10                  15      


Pro Gly Pro 
            


<210>  66
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Self-cleaving polypeptide comprising 2A site

<400>  66

Thr Leu Asn Phe Asp Leu Leu Lys Leu Ala Gly Asp Val Glu Ser Asn 
1               5                   10                  15      


Pro Gly Pro 
            


<210>  67
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Self-cleaving polypeptide comprising 2A site

<400>  67

Leu Leu Lys Leu Ala Gly Asp Val Glu Ser Asn Pro Gly Pro 
1               5                   10                  


<210>  68
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Self-cleaving polypeptide comprising 2A site

<400>  68

Asn Phe Asp Leu Leu Lys Leu Ala Gly Asp Val Glu Ser Asn Pro Gly 
1               5                   10                  15      


Pro 
    


<210>  69
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Self-cleaving polypeptide comprising 2A site

<400>  69

Gln Leu Leu Asn Phe Asp Leu Leu Lys Leu Ala Gly Asp Val Glu Ser 
1               5                   10                  15      


Asn Pro Gly Pro 
            20  


<210>  70
<211>  24
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Self-cleaving polypeptide comprising 2A site

<400>  70

Ala Pro Val Lys Gln Thr Leu Asn Phe Asp Leu Leu Lys Leu Ala Gly 
1               5                   10                  15      


Asp Val Glu Ser Asn Pro Gly Pro 
            20                  


<210>  71
<211>  40
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Self-cleaving polypeptide comprising 2A site

<400>  71

Val Thr Glu Leu Leu Tyr Arg Met Lys Arg Ala Glu Thr Tyr Cys Pro 
1               5                   10                  15      


Arg Pro Leu Leu Ala Ile His Pro Thr Glu Ala Arg His Lys Gln Lys 
            20                  25                  30          


Ile Val Ala Pro Val Lys Gln Thr 
        35                  40  


<210>  72
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Self-cleaving polypeptide comprising 2A site

<400>  72

Leu Asn Phe Asp Leu Leu Lys Leu Ala Gly Asp Val Glu Ser Asn Pro 
1               5                   10                  15      


Gly Pro 
        


<210>  73
<211>  40
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Self-cleaving polypeptide comprising 2A site

<400>  73

Leu Leu Ala Ile His Pro Thr Glu Ala Arg His Lys Gln Lys Ile Val 
1               5                   10                  15      


Ala Pro Val Lys Gln Thr Leu Asn Phe Asp Leu Leu Lys Leu Ala Gly 
            20                  25                  30          


Asp Val Glu Ser Asn Pro Gly Pro 
        35                  40  


<210>  74
<211>  33
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Self-cleaving polypeptide comprising 2A site

<400>  74

Glu Ala Arg His Lys Gln Lys Ile Val Ala Pro Val Lys Gln Thr Leu 
1               5                   10                  15      


Asn Phe Asp Leu Leu Lys Leu Ala Gly Asp Val Glu Ser Asn Pro Gly 
            20                  25                  30          


Pro 
    


<210>  75
<211>  10
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Consensus Kozak sequence

<400>  75
gccrccatgg                                                              10


<210>  76
<211>  22
<212>  DNA
<213>  Homo sapiens

<400>  76
tggggatggg aatatcttac ag                                                22


<210>  77
<211>  298
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized I-OnuI variant CBLB.E3

<400>  77

Ser Ile Asn Pro Trp Ile Leu Thr Gly Phe Ala Asp Ala Glu Gly Cys 
1               5                   10                  15      


Phe Arg Leu Asp Ile Arg Asn Ala Asn Asp Leu Arg Ala Gly Tyr Arg 
            20                  25                  30          


Thr Arg Leu Ala Phe Glu Ile Val Leu His Asn Lys Asp Lys Ser Ile 
        35                  40                  45              


Leu Glu Asn Ile Gln Ser Thr Trp Lys Val Gly Thr Ile Tyr Asn Ala 
    50                  55                  60                  


Gly Asp Asn Ala Val Arg Leu Gln Val Thr Arg Phe Glu Asp Leu Lys 
65                  70                  75                  80  


Val Ile Ile Asp His Phe Glu Lys Tyr Pro Leu Ile Thr Gln Lys Leu 
                85                  90                  95      


Gly Asp Tyr Lys Leu Phe Lys Gln Ala Phe Ser Val Met Glu Asn Lys 
            100                 105                 110         


Glu His Leu Lys Glu Asn Gly Ile Lys Glu Leu Val Arg Ile Lys Ala 
        115                 120                 125             


Lys Met Asn Trp Gly Leu Asn Asp Glu Leu Lys Lys Ala Phe Pro Glu 
    130                 135                 140                 


Asn Ile Ser Lys Glu Arg Ser Leu Ile Asn Lys Asn Ile Pro Asn Leu 
145                 150                 155                 160 


Lys Trp Leu Ala Gly Phe Thr Ser Gly Asp Gly Ser Phe Val Val Glu 
                165                 170                 175     


Leu Lys Lys Arg Arg Ser Pro Val Lys Val Gly Val Arg Leu Arg Phe 
            180                 185                 190         


Ser Ile Thr Gln His Ile Arg Asp Lys Asn Leu Met Asn Ser Leu Ile 
        195                 200                 205             


Thr Tyr Leu Gly Cys Gly Arg Ile Val Glu Asn Asn Lys Ser Glu His 
    210                 215                 220                 


Ser Trp Leu Glu Phe Ile Val Thr Lys Phe Ser Asp Ile Asn Asp Lys 
225                 230                 235                 240 


Ile Ile Pro Val Phe Gln Glu Asn Thr Leu Ile Gly Val Lys Leu Glu 
                245                 250                 255     


Asp Phe Glu Asp Trp Cys Lys Val Ala Lys Leu Ile Glu Glu Lys Lys 
            260                 265                 270         


His Leu Thr Glu Ser Gly Leu Asp Glu Ile Lys Lys Ile Lys Leu Asn 
        275                 280                 285             


Met Asn Lys Gly Arg Val Phe Ser Gly Arg 
    290                 295             


<210>  78
<211>  298
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized I-OnuI variant CBLB.F6

<400>  78

Ser Ile Asn Pro Trp Ile Leu Thr Gly Phe Ala Asp Ala Glu Gly Cys 
1               5                   10                  15      


Phe Arg Leu Asp Ile Arg Asn Ala Asn Asp Leu Arg Ala Gly Tyr Arg 
            20                  25                  30          


Thr Arg Leu Ala Phe Glu Ile Val Leu His Asn Lys Asp Lys Ser Ile 
        35                  40                  45              


Leu Glu Asn Ile Gln Ser Thr Trp Lys Val Gly Thr Ile Tyr Asn Ala 
    50                  55                  60                  


Gly Asp Asn Ala Val Arg Leu Gln Val Thr Arg Phe Glu Asp Leu Lys 
65                  70                  75                  80  


Val Ile Ile Asp His Phe Glu Lys Tyr Pro Leu Ile Thr Gln Lys Leu 
                85                  90                  95      


Gly Asp Tyr Lys Leu Phe Lys Gln Ala Phe Ser Val Met Glu Asn Lys 
            100                 105                 110         


Glu His Leu Lys Glu Asn Gly Ile Lys Glu Leu Val Arg Ile Lys Ala 
        115                 120                 125             


Lys Met Asn Trp Gly Leu Asn Asp Glu Leu Lys Lys Ala Phe Pro Glu 
    130                 135                 140                 


Asn Ile Ser Lys Glu Arg Pro Leu Ile Asn Lys Asn Ile Pro Asn Leu 
145                 150                 155                 160 


Lys Trp Leu Ala Gly Phe Thr Ser Gly Asp Gly Ser Phe Met Val Glu 
                165                 170                 175     


Leu Met Lys Asn Lys Asn Asn Val Ile Val Arg Val Arg Leu Arg Phe 
            180                 185                 190         


Ser Ile Ser Gln His Ile Arg Asp Lys Asn Leu Met Asn Ser Leu Ile 
        195                 200                 205             


Thr Tyr Leu Gly Cys Gly Arg Ile Val Glu Asn Asn Lys Ser Glu His 
    210                 215                 220                 


Ser Trp Leu Glu Phe Ile Val Thr Lys Phe Ser Asp Ile Asn Asp Lys 
225                 230                 235                 240 


Ile Ile Pro Val Phe Gln Glu Asn Thr Leu Ile Gly Val Lys Leu Glu 
                245                 250                 255     


Asp Phe Glu Asp Trp Cys Lys Val Ala Lys Leu Ile Glu Glu Lys Lys 
            260                 265                 270         


His Leu Thr Glu Ser Gly Leu Asp Glu Ile Lys Lys Ile Lys Leu Asn 
        275                 280                 285             


Met Asn Lys Gly Arg Val Phe Ser Gly Arg 
    290                 295             


<210>  79
<211>  298
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized I-OnuI variant CBLB.E6

<400>  79

Ser Ile Asn Pro Trp Ile Leu Thr Gly Phe Ala Asp Ala Glu Gly Cys 
1               5                   10                  15      


Phe Arg Leu Asp Ile Arg Asn Ala Asn Asp Leu Arg Ala Gly Tyr Arg 
            20                  25                  30          


Thr Arg Leu Ser Phe Glu Ile Ser Leu His Asn Lys Asp Lys Ser Ile 
        35                  40                  45              


Leu Glu Asn Ile Gln Ser Thr Trp Lys Val Gly Thr Ile Tyr Asn Ala 
    50                  55                  60                  


Gly Asp Asn Ala Val Arg Leu Gln Val Thr Arg Phe Glu Asp Leu Lys 
65                  70                  75                  80  


Val Ile Ile Asp His Phe Glu Lys Tyr Pro Leu Ile Thr Gln Lys Leu 
                85                  90                  95      


Gly Asp Tyr Lys Leu Phe Lys Gln Ala Phe Ser Val Met Glu Asn Lys 
            100                 105                 110         


Glu His Leu Lys Glu Asn Gly Ile Lys Glu Leu Val Arg Ile Lys Ala 
        115                 120                 125             


Lys Met Asn Trp Gly Leu Asn Asp Glu Leu Lys Lys Ala Phe Pro Glu 
    130                 135                 140                 


Asn Ile Ser Lys Glu Arg Pro Leu Ile Asn Lys Asn Ile Pro Asn Leu 
145                 150                 155                 160 


Lys Trp Leu Ala Gly Phe Thr Ser Gly Asp Gly Ser Phe Met Val Glu 
                165                 170                 175     


Leu Met Lys Asn Lys Asn Asn Val Ile Val Arg Val Arg Leu Arg Phe 
            180                 185                 190         


Ser Ile Ser Gln His Ile Arg Asp Lys Asn Leu Met Asn Ser Leu Ile 
        195                 200                 205             


Thr Tyr Leu Gly Cys Gly Arg Ile Val Glu Asn Asn Lys Ser Glu His 
    210                 215                 220                 


Ser Trp Leu Glu Phe Ile Val Thr Lys Phe Ser Asp Ile Asn Asp Lys 
225                 230                 235                 240 


Ile Ile Pro Val Phe Gln Glu Asn Thr Leu Ile Gly Val Lys Leu Glu 
                245                 250                 255     


Asp Phe Glu Asp Trp Cys Lys Val Ala Lys Leu Ile Glu Glu Lys Lys 
            260                 265                 270         


His Leu Thr Glu Ser Gly Leu Asp Glu Ile Lys Lys Ile Lys Leu Asn 
        275                 280                 285             


Met Asn Lys Gly Arg Val Phe Ser Gly Arg 
    290                 295             


<210>  80
<211>  298
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized I-OnuI variant CBLB.D2

<400>  80

Ser Ile Asn Pro Trp Ile Leu Thr Gly Phe Ala Asp Ala Glu Gly Cys 
1               5                   10                  15      


Phe Arg Leu Asp Ile His Asn Ala Asn Val Leu Arg Ser Gly Tyr Arg 
            20                  25                  30          


Thr Arg Leu Ser Phe Glu Ile Val Leu His Asn Lys Asp Lys Ser Ile 
        35                  40                  45              


Leu Glu Asn Ile Gln Ser Thr Trp Lys Val Gly Lys Ile Tyr Asn Ala 
    50                  55                  60                  


Gly Asp Asn Ala Val Arg Leu Gln Val Thr Arg Phe Glu Asp Leu Lys 
65                  70                  75                  80  


Val Ile Ile Asp His Phe Glu Lys Tyr Pro Leu Ile Thr Gln Lys Leu 
                85                  90                  95      


Gly Asp Tyr Lys Leu Phe Lys Gln Ala Phe Ser Val Met Glu Asn Lys 
            100                 105                 110         


Glu His Leu Lys Glu Asn Gly Ile Lys Glu Leu Val Arg Ile Lys Ala 
        115                 120                 125             


Lys Met Asn Trp Gly Leu Asn Asp Glu Leu Lys Lys Ala Phe Pro Glu 
    130                 135                 140                 


Asn Ile Ser Lys Glu Arg Pro Leu Ile Asn Lys Asn Ile Pro Asn Leu 
145                 150                 155                 160 


Lys Trp Leu Ala Gly Phe Thr Ser Gly Asp Gly Ser Phe Met Val Glu 
                165                 170                 175     


Leu Met Lys Asn Lys Asn Asn Val Ile Val Arg Val Arg Leu Arg Phe 
            180                 185                 190         


Ser Ile Ser Gln His Ile Arg Asp Lys Asn Leu Met Asn Ser Leu Ile 
        195                 200                 205             


Thr Tyr Leu Gly Cys Gly Arg Ile Val Glu Asn Asn Lys Ser Glu His 
    210                 215                 220                 


Ser Trp Leu Glu Phe Ile Val Thr Lys Phe Ser Asp Ile Asn Asp Lys 
225                 230                 235                 240 


Ile Ile Pro Val Phe Gln Glu Asn Thr Leu Ile Gly Val Lys Leu Glu 
                245                 250                 255     


Asp Phe Glu Asp Trp Cys Lys Val Ala Lys Leu Ile Glu Glu Lys Lys 
            260                 265                 270         


His Leu Thr Glu Ser Gly Leu Asp Glu Ile Lys Lys Ile Lys Leu Asn 
        275                 280                 285             


Met Asn Lys Gly Arg Val Phe Ser Gly Arg 
    290                 295             


<210>  81
<211>  298
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized I-OnuI variant CBLB.C2

<400>  81

Ser Ile Asn Pro Trp Ile Leu Thr Gly Phe Ala Asp Ala Glu Gly Cys 
1               5                   10                  15      


Phe Gly Leu Tyr Ile His Asn Ser Asn Val Leu Arg Ser Gly Tyr Arg 
            20                  25                  30          


Thr Arg Leu Ser Phe Glu Ile Ser Leu His Asn Lys Asp Lys Ser Ile 
        35                  40                  45              


Leu Glu Asn Ile Gln Ser Thr Trp Lys Val Gly Thr Ile Tyr Asn Ala 
    50                  55                  60                  


Gly Asp Asn Ala Val Arg Leu Gln Val Thr Arg Phe Glu Asp Leu Lys 
65                  70                  75                  80  


Val Ile Ile Asp His Phe Glu Lys Tyr Pro Leu Ile Thr Gln Lys Leu 
                85                  90                  95      


Gly Asp Tyr Lys Leu Phe Lys Gln Ala Phe Ser Leu Met Glu Asn Lys 
            100                 105                 110         


Glu His Leu Lys Glu Asn Gly Ile Lys Glu Leu Val Arg Ile Lys Ala 
        115                 120                 125             


Lys Met Asn Trp Gly Leu Asn Asp Glu Leu Lys Lys Ala Phe Pro Glu 
    130                 135                 140                 


Asn Ile Ser Lys Glu Arg Pro Leu Ile Asn Lys Asn Ile Pro Asn Leu 
145                 150                 155                 160 


Lys Trp Leu Ala Gly Phe Thr Ser Gly Asp Gly Ser Phe Met Val Glu 
                165                 170                 175     


Leu Met Lys Asn Lys Asn Asn Val Ile Val Arg Val Arg Leu Arg Phe 
            180                 185                 190         


Ser Ile Ser Gln His Ile Arg Asp Lys Asn Leu Met Asn Ser Leu Ile 
        195                 200                 205             


Thr Tyr Leu Gly Cys Gly Arg Ile Val Glu Asn Asn Lys Ser Glu His 
    210                 215                 220                 


Ser Trp Leu Glu Phe Ile Val Thr Lys Phe Ser Asp Ile Asn Asp Lys 
225                 230                 235                 240 


Ile Ile Pro Val Phe Gln Glu Asn Thr Leu Ile Gly Val Lys Leu Glu 
                245                 250                 255     


Asp Phe Glu Asp Trp Cys Lys Val Ala Lys Leu Ile Glu Glu Lys Lys 
            260                 265                 270         


His Leu Thr Glu Ser Gly Leu Asp Glu Ile Lys Lys Ile Lys Leu Asn 
        275                 280                 285             


Met Asn Lys Gly Arg Val Phe Ser Gly Arg 
    290                 295             


<210>  82
<211>  298
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized I-OnuI variant CBLB.B5

<400>  82

Ser Ile Asn Pro Trp Ile Leu Thr Gly Phe Ala Asp Ala Glu Gly Cys 
1               5                   10                  15      


Phe Arg Leu Asp Ile His Asn Ala Asn Val Leu Arg Ser Gly Tyr Arg 
            20                  25                  30          


Thr Arg Leu Ser Phe Glu Ile Val Leu His Asn Lys Asp Lys Ser Ile 
        35                  40                  45              


Leu Glu Asn Ile Gln Ser Thr Trp Lys Val Gly Thr Ile Tyr Asn Ala 
    50                  55                  60                  


Gly Asp Asn Ala Val Arg Leu Gln Val Thr Arg Phe Glu Asp Leu Lys 
65                  70                  75                  80  


Val Ile Ile Asp His Phe Glu Lys Tyr Pro Leu Ile Thr Gln Lys Leu 
                85                  90                  95      


Gly Asp Tyr Lys Leu Phe Lys Gln Ala Phe Ser Leu Met Glu Asn Lys 
            100                 105                 110         


Glu His Leu Lys Glu Asn Gly Ile Lys Glu Leu Val Arg Ile Lys Ala 
        115                 120                 125             


Lys Met Asn Trp Gly Leu Asn Asp Glu Leu Lys Lys Ala Phe Pro Glu 
    130                 135                 140                 


Asn Ile Ser Lys Glu Arg Pro Leu Ile Asn Lys Asn Ile Pro Asn Leu 
145                 150                 155                 160 


Lys Trp Leu Ala Gly Phe Thr Ser Gly Asp Gly Ser Phe Val Val Glu 
                165                 170                 175     


Leu Lys Lys Arg Arg Ser Pro Val Lys Val Gly Val Arg Leu Arg Phe 
            180                 185                 190         


Gly Ile Thr Gln His Ile Arg Asp Lys Asn Leu Met Asn Ser Leu Ile 
        195                 200                 205             


Thr Tyr Leu Gly Cys Gly Arg Ile Val Glu Asn Asn Lys Ser Glu His 
    210                 215                 220                 


Ser Trp Leu Glu Phe Ile Val Thr Lys Phe Ser Asp Ile Asn Asp Lys 
225                 230                 235                 240 


Ile Ile Pro Val Phe Gln Glu Asn Thr Leu Ile Gly Val Lys Leu Glu 
                245                 250                 255     


Asp Phe Glu Asp Trp Cys Lys Val Ala Lys Leu Ile Glu Glu Lys Lys 
            260                 265                 270         


His Leu Thr Glu Ser Gly Leu Asp Glu Ile Lys Lys Ile Lys Leu Asn 
        275                 280                 285             


Met Asn Lys Gly Arg Val Phe Ser Gly Arg 
    290                 295             


<210>  83
<211>  298
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized I-OnuI variant CBLB.A8

<400>  83

Ser Ile Asn Pro Trp Ile Leu Thr Gly Phe Ala Asp Ala Glu Gly Cys 
1               5                   10                  15      


Phe Arg Leu Asp Ile Arg Asn Ala Asn Asp Leu Arg Ala Gly Tyr Arg 
            20                  25                  30          


Thr Arg Leu Ala Phe Glu Ile Val Leu His Asn Lys Asp Lys Ser Ile 
        35                  40                  45              


Leu Glu Asn Ile Gln Ser Thr Trp Lys Val Gly Thr Ile Tyr Asn Ala 
    50                  55                  60                  


Gly Asp Asn Ala Val Arg Leu Gln Val Thr Arg Phe Glu Asp Leu Lys 
65                  70                  75                  80  


Val Ile Ile Gly His Phe Glu Lys Tyr Pro Leu Ile Thr Gln Lys Leu 
                85                  90                  95      


Gly Asp Tyr Lys Leu Phe Lys Gln Ala Phe Ser Val Met Glu Asn Lys 
            100                 105                 110         


Glu His Leu Lys Glu Asn Gly Ile Lys Glu Leu Val Arg Ile Lys Ala 
        115                 120                 125             


Lys Met Asn Trp Gly Leu Asn Asp Glu Leu Lys Lys Ala Phe Pro Glu 
    130                 135                 140                 


Asn Ile Ser Lys Glu Arg Pro Leu Ile Asn Lys Asn Ile Pro Asn Leu 
145                 150                 155                 160 


Lys Trp Leu Ala Gly Phe Thr Ser Gly Asp Gly Ser Phe Met Val Glu 
                165                 170                 175     


Leu Met Lys Asn Lys Asn Asn Val Ile Val Arg Val Arg Leu Arg Phe 
            180                 185                 190         


Ser Ile Ser Gln His Ile Arg Asp Lys Asn Leu Met Asn Ser Leu Ile 
        195                 200                 205             


Thr Tyr Leu Gly Cys Gly Arg Ile Val Glu Asn Asn Lys Ser Glu His 
    210                 215                 220                 


Ser Trp Leu Glu Phe Ile Val Thr Lys Phe Ser Asp Ile Asn Asp Lys 
225                 230                 235                 240 


Ile Ile Pro Val Phe Gln Glu Asn Thr Leu Ile Gly Val Lys Leu Glu 
                245                 250                 255     


Asp Phe Glu Asp Trp Cys Lys Val Ala Lys Leu Ile Glu Glu Lys Lys 
            260                 265                 270         


His Leu Thr Glu Ser Gly Leu Asp Glu Ile Lys Lys Ile Lys Leu Asn 
        275                 280                 285             


Met Asn Lys Gly Arg Val Phe Ser Gly Arg 
    290                 295             


<210>  84
<211>  39
<212>  DNA
<213>  Homo sapiens

<400>  84
tggggatggg aatatcttac agaccatacc tcataacaa                              39


