                         SEQUENCE LISTING

<110>  The University Court of the University of Edinburgh
 
<120>  Genetically modified Avians and Method for the Reconstitution 
       Thereof

<130>  P191530.WO.01

<150>  GB1816633.0
<151>  2018-10-12

<160>  18    

<170>  PatentIn version 3.5

<210>  1
<211>  1317
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  2a-iCaspase9-Bam H1 site mutated

<400>  1
ggatccggag ctactaactt cagcctgctg aagcaggctg gagacgtgga ggagaaccct       60

ggacctatgc tcgagggagt gcaggtggag actatctccc caggagacgg gcgcaccttc      120

cccaagcgcg gccagacctg cgtggtgcac tacaccggga tgcttgaaga tggaaagaaa      180

gttgattcct cccgggacag aaacaagccc tttaagttta tgctaggcaa gcaggaggtg      240

atccgaggct gggaagaagg ggttgcccag atgagtgtgg gtcagagagc caaactgact      300

atatctccag attatgccta tggtgccact gggcacccag gcatcatccc accacatgcc      360

actctcgtct tcgatgtgga gcttctaaaa ctggaatctg gcggtggttc cggagtcgac      420

ggatttggtg atgtcggtgc tcttgagagt ttgaggggaa atgcagattt ggcttacatc      480

ctgagcatgg agccctgtgg ccactgcctc attatcaaca atgtgaactt ctgccgtgag      540

tccgggctcc gcacccgcac tggctccaac atcgactgtg agaagttgcg gcgtcgcttc      600

tcctcgctgc atttcatggt ggaggtgaag ggcgacctga ctgccaagaa aatggtgctg      660

gctttgctgg agctggcgcg gcaggaccac ggtgctctgg actgctgcgt ggtggtcatt      720

ctctctcacg gctgtcaggc cagccacctg cagttcccag gggctgtcta cggcacagat      780

ggatgccctg tgtcggtcga gaagattgtg aacatcttca atgggaccag ctgccccagc      840

ctgggaggga agcccaagct ctttttcatc caggcctgtg gtggggagca gaaagaccat      900

gggtttgagg tggcctccac ttcccctgaa gacgagtccc ctggcagtaa ccccgagcca      960

gatgccaccc cgttccagga aggtttgagg accttcgacc agctggacgc catatctagt     1020

ttgcccacac ccagtgacat ctttgtgtcc tactctactt tcccaggttt tgtttcctgg     1080

agggacccca agagtggctc ctggtacgtt gagaccctgg acgacatctt tgagcagtgg     1140

gctcactctg aagacctgca gtccctcctg cttagggtcg ctaatgctgt ttcggtgaaa     1200

gggatttata aacagatgcc tggttgcttt aatttcctcc ggaaaaaact tttctttaaa     1260

acatcagtcg actatccgta cgacgtacca gactacgcac tcgacctcga cggatcc        1317


<210>  2
<211>  1315
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  2a-aviCaspase9

<400>  2
agggatccgg agctactaac ttcagcctgc tgaagcaggc tggagacgtg gaggagaacc       60

ctggacctat gctcgaggga gtgcaggtgg agactatctc cccaggagac gggcgcacct      120

tccccaagcg cggccagacc tgcgtggtgc actacaccgg gatgcttgaa gatggaaaga      180

aagttgattc ctcccgggac agaaacaagc cctttaagtt tatgcttggc aagcaggagg      240

tgatccgagg ctgggaagaa ggggttgccc agatgagtgt gggtcagaga gccaaactga      300

ctatatctcc agattatgcc tatggtgcca ctgggcaccc aggcatcatc ccaccacatg      360

ccactctcgt cttcgatgtg gagcttctaa aactggaatc tggcggtggt tccggagtcg      420

acggtgtctc tgtgaattgc agaccagcta ggatgcatgc tagtgcatgc caggtgtacc      480

agctgcgagc agacccttgt gggcactgcc tgatcttcaa caatgtcagc ttcagcagag      540

actctgatct gtcgactcga gctggctctg acatagactg tgagaagctg gagaagcgtt      600

tcaggtccct gtgcttccac gtccggaccc tgcggaacct caaagctcag gaaattgatg      660

tggagctgcg gaagctggcg cggctcgacc acagtgccct ggactgctgc ctcgtggtca      720

tcctctccca tggttgccag acaagccata ttcagtttcc cggagggatt tatggaacag      780

atggcaaaat cattccaatc gaaaggattg tgaactattt caatgggtcc cagtgcccga      840

gtttgagagg aaaacccaaa ctcttcttca tccaggcctg tggaggagaa caaaaggacc      900

aaggatttga ggtggattgt gaatcacccc aagatgaaac ttgccgacgt tccatagagt      960

cggatgcgat tcctttccag gctccatcag ggaatgagga cgagccagac gccgtcgcca     1020

gtttgcccac tcctggtgac atcttggtgt cctattcaac ttttccaggt tttgtgtcct     1080

ggagggacaa ggtgagtggc tcgtggtacg tggaaacctt ggacagcgta ctggaacatt     1140

acgcccgttc tgaagacctg cttaccatgc tacttcgggt gtcagacatc gtatccacca     1200

aggggaggta caagcagatc ccgggctgtt tcaacttcct tcgtaaaaaa ttcttcttcc     1260

tgtgcaaggt cgactatccg tacgacgtac cagactacgc actcgacgga tccaa          1315


<210>  3
<211>  5985
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Leftarm-GFP-2a-Nitroreductase-T2a-Right arm

<400>  3
tttttttctt tgagatgagt atcttattgc agctctgtgc ataccccttg aaaatccgta       60

ggtgatgtat ttatgttgac tgaaaatgga gtcattcaaa aattgatgac ttcttccttt      120

tctcttttta atctcgaaac ctgttctcag attcctttat cagaacaaaa agcacggctg      180

catgtttttc accgttcaca cgactgtgtt tagccagcgt atctaaatgc ataacatgat      240

ttgccataac ttgagcctgc cataatcaga gcctcatttt gaaagctgtc atggtctgaa      300

acatagcatg ggtaagatga ttttcacctt gatgatgcat gtttaactca tttcaacgag      360

aggtcaaatc catccaaaaa tgctaaatct atcaaccagt tttcatgttc aagttctggc      420

acaaattttc gttctgactc catacgtgat tagatttcat tttgcaaatc atgaaaacta      480

ttgccaaaac atacaatttt aagtcagcag ttttactgcc caaatttgca caagcacatg      540

taacgtgaca gacaaaaacc cactggacag agacaaaata ctgggtttgg ccagtatggt      600

ttggctaagc cacgtttttc agggcaagaa ttgcctcacc tttttttata ttggaatcaa      660

attctcaagt gtaacagcct ggcgccatct cagctgccat taagtagcat gtgctgcaac      720

aagatgtcta ccacacactc tgctctgggt ggtgggggca caccagtgtg gacggcaacc      780

atgacacaag catagagtct tggcagaggt ccattgggtg catttatagt ggttcacact      840

ggggggttat cacagaatca tggaggttgg aaggtacctc cgggggtcat caaatccaac      900

cacttgacaa agcaggttcc ctaaagtaga ttgctcaaga acagtcacag cactgctgct      960

cacagaaaat ctctagttgg taaggttacc tttttttttg ttgtcgctcc cagttaaacc     1020

aaggtgggaa cacatccttt tcatagttgt attgtaggga tgtttatagc tattgctagg     1080

gaaaactgaa cagcgtgcaa ggaagtcagc actgacacag ctttcccacg tgagagagct     1140

atttcaaagc aagatcagca catatcccaa tctgtacttc ctcaaacaca gcccaaaacc     1200

gatagcaagg ccaagcagca gcactgctcc ttcaaggaaa ctgctgcata atctgaattt     1260

cagacggcag gaggaaacaa ggcagcagac tgatgaccta ccaccctgag tctcagctac     1320

atgcgatccg agccactcca actctgcttc ctgcagccct tccttcacgc tcatcttttg     1380

caccttaggc actcttataa ttcaagtact ttgtggcttt gggatatttg aagagcttgg     1440

tcagttagtc acaagtctgg ccacgtgcta tcatattagt ttgaaaagca atggagacac     1500

catctgctga tgctcaaagt ggttacaacc aaaacacaaa aaagcagagc tgtgggaaga     1560

attcaacatt ttgattatgc aagaagctag tcccagcctt gaaatccacc atctgcatca     1620

tgaaagacct aagtagttaa agccacagca gacatacagc ttctatttcc ttaccttctt     1680

catcattaac tacaggtctt ggaagatttt tgctgggaaa aagcttttat tgcaagaact     1740

gtaatttatt aacagggaaa catgaaataa atgtgtaaat tctcctgcac tcccactgtc     1800

attaaaaacg gctttaagaa agagtattca gtaactgcct gcattgtgtt gtgactttct     1860

actctgtgac acacagcctt ctgggcaaag cacatattct gccatgcatg tgggtcgtgc     1920

cttggaaaat gggaacccac attcactgag ggcctcttga tgagctttcc ccttgagaac     1980

agcgaggtct catggatatc ttctcttctc caagccaaat aagcccagat ccctcagctt     2040

tccttcatgg agaggctcca gccctctgat catgcctgca gcccttctct ggacctgctc     2100

cagcagcccc acacgctcct catgctggga ccccagatct gcacatggta ttgcacatgg     2160

ggcctcacaa cggcagagct gagagggaca attccctccc tcagccttta attctgcacg     2220

tacttaattt tgtctgtatt ttttttgcaa tagaatagcc tgcatgctag ttgctgtgtc     2280

gcacagctga attcactagg ttcctgtgaa acaaagggca atcccacagc cactgtagca     2340

cgtgaggagc cacacaggtg ctctaattcc tacaggacag gcctagggac agagcggccc     2400

taggactgcc ctcccgcacc tcctagcttc accttttgcc cgcgatcttt aagtaccctg     2460

aagcataaac agggaaagcg ccgcccgcag cctcaccctg cttcccgccc aacgcggcac     2520

cgcccaggcc gcagccgccc actaagagca ctagcgccac cttctcaccc cacccccacc     2580

acgcgttcct agcggccctg agagctgctg cgcatgcgcc gcctgacgat tcgccctccc     2640

attggctggc ggtcgaagca cggcgggggc acgcggtggc ggctatataa ggcgtctcgg     2700

aagacggcgc catgctattt ggagcggaga gtgaaagtta cagttcctgg tgctggtagg     2760

gagtgtggcg cggagcggag cgctgcggct catcggaacc acaatggagc catagcagag     2820

ccgggcgtgg gggcaagggc agtgcgtgct ggggagggct ccgtcgcgtg gccacgtcgc     2880

gagagccgtc gggatggtgg cgtcagggcg gggggtgctg ctaacgtgct cctggtcctg     2940

caggtgggct gctggcattc gccatggtga gcaagggcga ggagctgttc accggggtgg     3000

tgcccatcct ggtcgagctg gacggcgacg taaacggcca caagttcagc gtgtccggcg     3060

agggcgaggg cgatgccacc tacggcaagc tgaccctgaa gttcatctgc accaccggca     3120

agctgcccgt gccctggccc accctcgtga ccaccctgac ctacggcgtg cagtgcttca     3180

gccgctaccc cgaccacatg aagcagcacg acttcttcaa gtccgccatg cccgaaggct     3240

acgtccagga gcgcaccatc ttcttcaagg acgacggcaa ctacaagacc cgcgccgagg     3300

tgaagttcga gggcgacacc ctggtgaacc gcatcgagct gaagggcatc gacttcaagg     3360

aggacggcaa catcctgggg cacaagctgg agtacaacta caacagccac aacgtctata     3420

tcatggccga caagcagaag aacggcatca aggtgaactt caagatccgc cacaacatcg     3480

aggacggcag cgtgcagctc gccgaccact accagcagaa cacccccatc ggcgacggcc     3540

ccgtgctgct gcccgacaac cactacctga gcacccagtc cgccctgagc aaagacccca     3600

acgagaagcg cgatcacatg gtcctgctgg agttcgtgac cgccgccggg atcactctcg     3660

gcatggacga gctgtacaag ggatccggag ctactaactt cagcctgctg aagcaggctg     3720

gagacgtgga ggagaaccct ggacctatgg atatcatcag cgtggccctg aagagacaca     3780

gcaccaaggc cttcgatgcc agcaagaagc tgacccccga gcaggccgag cagatcaaga     3840

ccctgctgca gtacagcccc agcagccaga acagccagcc ctggcacttc atcgtggcca     3900

gcaccgagga aggcaaggcc agagtggcca agagcgccgc cggcaactac gtgttcagcg     3960

agagaaagat gctggatgcc agccacgtgg tggtgttctg cgccaagacc gctatggatg     4020

atgtgtggct gaagctggtg gtggatcagg aggatgccga tggcagattc gccacccccg     4080

aggccaaggc cgccaacgat aagggcagaa agttcaccgc cgatatgcac agaaaggatc     4140

tgcacgatga tgccgagtgg atggccaagc aggtgtacct gaacgtgggc aacttcctgc     4200

tcggcgtggc cgccctgggc ctggatgccg tgcccatcga gggcttcgat gccgccatcc     4260

tggatgccga gttcggcctg aaggagaagg gctacaccag cctggtggtg gtgcccgtgg     4320

gccaccacag cgtggaggat ttcaacgcca ccctccccaa gagcagactg ccccagaaca     4380

tcaccctgac cgaggtggga tccggagagg gcagaggaag tctgctaaca tgcggtgacg     4440

tcgaggagaa tcctggacct atggaggagg attgggatac cgaactcgag caggaggcgg     4500

cagcggcttc ccaggggcgt tctgaggagc aggcgtggat ggtgagctgt gtccagggga     4560

gggcggtgcg gcagggagcg gggcactggg atggcccggt ctgggaaggg gaggccgaga     4620

ggccttcgca gtgcttcctg cagctccccg agcagtgcga agaaggaggt gccgggctct     4680

gctgtgggag ccgaaggcac ggagctgcct ggggagggaa tggctgtgtg cctgaggtgc     4740

cagagaccgg caagggctgt acagagaggc aacggttttg tgtacaaatc atttgtatgg     4800

gaaaccacaa aatcttgaag ctttattaca tggcagcgaa atactttggt gtgaagtaaa     4860

ggataagata gaggagtgta atgagagaca gctaaataat attttactac ttgtgggatg     4920

agtgaatatc aggaggaact gctgtaaatt tcaggaggac ctgttgtgaa tcttcagtag     4980

ttggcgccgc tcttacacat cttacagatg ccccttgagc aaagggggat aaggagagat     5040

gaacgggtta tccaaacagg tgatgagcta aaagtacagt tgcctaaaga agtagtagca     5100

tgtgctatca gaatgataat tttgttagtt tggggttagt ttcctgtagt ggtagatagc     5160

cacaacaaga aaaccgctta agtttttgta aaacaaaaaa agcacgatcc agaagtaaaa     5220

aatatgggta gttttttttg atgttcctct ctcacctggt gctttggcat actaatatgt     5280

gtctaattgt attaaacagg agaaatttaa acctaggctt tgctggaaat aaaatgttac     5340

aatgctacaa tgtgaaaagt aggtgctatt ctgaactgtt ttgggtggag tatctgaatc     5400

tttgaataat ttaagaggga ctgacatatt taaaatactt aaggataatc tgtagccatg     5460

ctgtaaaaga acaacagaaa tgcagttggg aaggtgatgg aaatagtttt attcatgtta     5520

ctggtggtct gaaacctttc taagcttaaa ctgtagaaaa aaattgcttc aaaagattgc     5580

actattactt tgggcgacaa atgtttttaa ttggttttaa gtgtttgtta gcaaagtgaa     5640

gttgatgcca ccataagtct gacaggaggc aagataaact tgtcttcata ctgcttgtgt     5700

ataacttggt tttgatgaca tttgtgtgtg aacattatgc acttcagtgt agcgaagttt     5760

aagaaacttt gaacagaata acttgaaaga gtgtgcacat gggtgcagaa gtcactttat     5820

ttcagttggg agacttagca cctaaatgca ctgttagttc acatacactt tgcttggcct     5880

gaaggtaaca ttgtgatgtc gctttttttc cctgtaggct aactctggca gaccaaacag     5940

cccatccctc cgcttctcca gcagaccaag cagccccttg tctgg                     5985


<210>  4
<211>  5155
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Left arm-2a-aviCaspase9-T2a-GFP-Right arm

<400>  4
cttcgtggct tggtgaagag atcttctgac ctcttcatca ccccctagaa ttaaggctgt       60

aatcatcatt tcagccattg cttaatccac tataatttct gcatgatttc agaaggctat      120

cttgcttcct tgaaactaat aatacctagt ttgtagtgtt tagggatgtg taaaatgtgt      180

ttatgtcaag attttagtta gtctgataag aattgtggaa gaattgcagc tactaaaaag      240

gcagactggg tagcacttcc caccttactc agatttagga gtctcaagac atgtagatgg      300

gtgaaattta ttattctttt ctctgcttgc ttttctggaa agctacctct atttggccag      360

cagttggctc tgaattcctt tctttaaagg agacctgact gctctcctgt ctgcctctta      420

cacagctgta ctggtgtgtc actgatagaa acgtttacct tgaaagtgac aagtgggggc      480

gttgataccc attaacaaca ttaaagggaa aatttcagga aacaagaaaa ctgagaggag      540

ttcagaatga aatgtaagcc ctgtgacaga ctcacactga tggtagtagg gtaactgatg      600

gagatgcatc tataacaatt ctaactttta tttcagaagt ctgtggacag gagcatacaa      660

acagtagtat cttgtctgtt taaccctgaa aaccgtctga ggaacacctt tgtatcacaa      720

gaagactact tcagggtatg tagtgaaagc aaaactaaat ctctaaaacc agctgatctt      780

aactttgttc atatacagga tgccatgaag acaaaggttt atctgtactt gcttgagatt      840

ttactttttg tatgtgcatt gagatgaatg actggttagc tctcagttgg ttaatactca      900

atgaaaattg cagaaattga gttcagtgga tttaagtgca ttgatacaag gctgcataag      960

aactgctgag cagtcagcta ttggatattt agagctaatc atccctcagg agcaatctgc     1020

tgaaaggtaa gcagattgca tcttgtaaac gagagagcag agttaaacgt ttgtggtctt     1080

tgctccactt aagtacccac agtggatgtc tatctgtact tttggttaaa aaatagataa     1140

tttctacaac agactgtagt taggtcagta cctggtcatc aggtattaat ggaaagcttt     1200

ttgctgtgca ttcaatcttc atagaggtct gctttccaat tacattctct ttgttttaag     1260

tataactttg aaactcaaat ataaaagcct gctacttttt tttgttctaa aaagacagat     1320

gtggactagg cacctgtact gtgaaaccag aatagagaag ctgttgggca gatttgaaga     1380

ggattgagta atatagagaa tgtcttgaga tatttgtgaa gcttttattg ctttgttgca     1440

attgttgtct agaaacatgg gctttttctg ttttttctcc tattccagga gaggagggcg     1500

catcacttca gaaaaggaag agcagtgctc aaaagtgttg gatccggagc tactaacttc     1560

agcctgctga agcaggctgg agacgtggag gagaaccctg gacctatgct cgagggagtg     1620

caggtggaga ctatctcccc aggagacggg cgcaccttcc ccaagcgcgg ccagacctgc     1680

gtggtgcact acaccgggat gcttgaagat ggaaagaaag ttgattcctc ccgggacaga     1740

aacaagccct ttaagtttat gcttggcaag caggaggtga tccgaggctg ggaagaaggg     1800

gttgcccaga tgagtgtggg tcagagagcc aaactgacta tatctccaga ttatgcctat     1860

ggtgccactg ggcacccagg catcatccca ccacatgcca ctctcgtctt cgatgtggag     1920

cttctaaaac tggaatctgg cggtggttcc ggagtcgacg gtgtctctgt gaattgcaga     1980

ccagctagga tgcatgctag tgcatgccag gtgtaccagc tgcgagcaga cccttgtggg     2040

cactgcctga tcttcaacaa tgtcagcttc agcagagact ctgatctgtc gactcgagct     2100

ggctctgaca tagactgtga gaagctggag aagcgtttca ggtccctgtg cttccacgtc     2160

cggaccctgc ggaacctcaa agctcaggaa attgatgtgg agctgcggaa gctggcgcgg     2220

ctcgaccaca gtgccctgga ctgctgcctc gtggtcatcc tctcccatgg ttgccagaca     2280

agccatattc agtttcccgg agggatttat ggaacagatg gcaaaatcat tccaatcgaa     2340

aggattgtga actatttcaa tgggtcccag tgcccgagtt tgagaggaaa acccaaactc     2400

ttcttcatcc aggcctgtgg aggagaacaa aaggaccaag gatttgaggt ggattgtgaa     2460

tcaccccaag atgaaacttg ccgacgttcc atagagtcgg atgcgattcc tttccaggct     2520

ccatcaggga atgaggacga gccagacgcc gtcgccagtt tgcccactcc tggtgacatc     2580

ttggtgtcct attcaacttt tccaggtttt gtgtcctgga gggacaaggt gagtggctcg     2640

tggtacgtgg aaaccttgga cagcgtactg gaacattacg cccgttctga agacctgctt     2700

accatgctac ttcgggtgtc agacatcgta tccaccaagg ggaggtacaa gcagatcccg     2760

ggctgtttca acttccttcg taaaaaattc ttcttcctgt gcaaggtcga ctatccgtac     2820

gacgtaccag actacgcact cgacggatcc ggagagggca gaggaagtct gctaacatgc     2880

ggtgacgtcg aggagaatcc tggacctatg gtgagcaagg gcgaggagct gttcaccggg     2940

gtggtgccca tcctggtcga gctggacggc gacgtaaacg gccacaagtt cagcgtgtcc     3000

ggcgagggcg agggcgatgc cacctacggc aagctgaccc tgaagttcat ctgcaccacc     3060

ggcaagctgc ccgtgccctg gcccaccctc gtgaccaccc tgacctacgg cgtgcagtgc     3120

ttcagccgct accccgacca catgaagcag cacgacttct tcaagtccgc catgcccgaa     3180

ggctacgtcc aggagcgcac catcttcttc aaggacgacg gcaactacaa gacccgcgcc     3240

gaggtgaagt tcgagggcga caccctggtg aaccgcatcg agctgaaggg catcgacttc     3300

aaggaggacg gcaacatcct ggggcacaag ctggagtaca actacaacag ccacaacgtc     3360

tatatcatgg ccgacaagca gaagaacggc atcaaggtga acttcaagat ccgccacaac     3420

atcgaggacg gcagcgtgca gctcgccgac cactaccagc agaacacccc catcggcgac     3480

ggccccgtgc tgctgcccga caaccactac ctgagcaccc agtccgccct gagcaaagac     3540

cccaacgaga agcgcgatca catggtcctg ctggagttcg tgaccgccgc cgggatcact     3600

ctcggcatgg acgagctgta caagtgatga acaaagactt tgaagtacat aaatgtatta     3660

ctttgatgtt aatacagttc agtttagtaa gatgtgtagt aaaaagtgta accttgttca     3720

aaaagttgct tcaagttgat gtttgtgttc tgttttacct gttccagaat agctattttt     3780

gcttgagaag tttgaagttg taagagttga aatatttcca ggttttatta ctagcttgca     3840

tgcttttcct gctaactaac tgaaatgcta atcttaagga atttatatgg ggaaggggaa     3900

aaaagaaaaa cactttgttt ggtacgtgtg gattttcttc tgagctttaa ggtacagttt     3960

gttgcatgtt aaaatttagt tcttattaaa ccacaacttt aagttactaa cgtcaaccag     4020

ttacctcttg cagttcaaaa gttgaagcag ttccttgtcc aagatggagt attttaaaac     4080

tgagctctta atcagtggaa cagaagacgt cacggtgtaa ctcaactgaa gccctttaag     4140

tcccggttct ctttagacta cctaatcaat gtctttgttt gctaacgaca gtttatctat     4200

gtgaatccta aaattcctat atgtaactta agatgcaaga atgtaattag ttacattggc     4260

tgctcagtgg agtatgactt ttttttttac tggattaatt ttagcaatac ctgtatctta     4320

aaattgtgag aaaatactgc atttaaaata tgcctaactt tgtgatgcaa tatgttaatc     4380

aaagaataca tgtaagcata ttttaataat aattatgtag attttagtca tgtattttga     4440

aacaattaaa atttttaatt ttgacttacc ttcccagtgt gagtgacatc ctaatataat     4500

acttctaaat cttaagctgc tttgagaaag gcatgcagcg tatttattga aggaattgaa     4560

gatttcttac cctacataag aattccagtt aggacaagtt tatagcaaca aactttcaca     4620

tttgctgtta gttctacctg cgattttgaa ggagtacaac tgagaacagc actcagtctt     4680

gtatgtgtgt tgggtcctag tctgattcat ttttcttatt actaccctta tacctcagtc     4740

tccaagtaaa aaaggaaata actcctcctt tgtagacgtg tatatgtgaa tgaatagaat     4800

ggcatgtccc acttcaaatg tctagaagta gatgttggtg aaacatgcaa taagagctga     4860

gttgctctgt acctggatag tgggctgtaa gatgcagcac aggagtgtcc caggactgtt     4920

gttcaggagt aggagtcagg ggagggaggc agggcttggg ggatagcaat aatagttggt     4980

gccgttctcc ataaaattac tcagaagcaa tgttctggca gcataaatcg acctaaagtt     5040

gttaactttt tctctgctca gaccgttccc tagcactaaa gatgctgtgt ccttaagtgt     5100

gtttccatac tatccatcac catgtttttc ccaacctatt gctttaatag tattg          5155


<210>  5
<211>  5161
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Left arm-2a-iCaspase9-T2a-GFP-Right arm

<400>  5
cttcgtggct tggtgaagag atcttctgac ctcttcatca ccccctagaa ttaaggctgt       60

aatcatcatt tcagccattg cttaatccac tataatttct gcatgatttc agaaggctat      120

cttgcttcct tgaaactaat aatacctagt ttgtagtgtt tagggatgtg taaaatgtgt      180

ttatgtcaag attttagtta gtctgataag aattgtggaa gaattgcagc tactaaaaag      240

gcagactggg tagcacttcc caccttactc agatttagga gtctcaagac atgtagatgg      300

gtgaaattta ttattctttt ctctgcttgc ttttctggaa agctacctct atttggccag      360

cagttggctc tgaattcctt tctttaaagg agacctgact gctctcctgt ctgcctctta      420

cacagctgta ctggtgtgtc actgatagaa acgtttacct tgaaagtgac aagtgggggc      480

gttgataccc attaacaaca ttaaagggaa aatttcagga aacaagaaaa ctgagaggag      540

ttcagaatga aatgtaagcc ctgtgacaga ctcacactga tggtagtagg gtaactgatg      600

gagatgcatc tataacaatt ctaactttta tttcagaagt ctgtggacag gagcatacaa      660

acagtagtat cttgtctgtt taaccctgaa aaccgtctga ggaacacctt tgtatcacaa      720

gaagactact tcagggtatg tagtgaaagc aaaactaaat ctctaaaacc agctgatctt      780

aactttgttc atatacagga tgccatgaag acaaaggttt atctgtactt gcttgagatt      840

ttactttttg tatgtgcatt gagatgaatg actggttagc tctcagttgg ttaatactca      900

atgaaaattg cagaaattga gttcagtgga tttaagtgca ttgatacaag gctgcataag      960

aactgctgag cagtcagcta ttggatattt agagctaatc atccctcagg agcaatctgc     1020

tgaaaggtaa gcagattgca tcttgtaaac gagagagcag agttaaacgt ttgtggtctt     1080

tgctccactt aagtacccac agtggatgtc tatctgtact tttggttaaa aaatagataa     1140

tttctacaac agactgtagt taggtcagta cctggtcatc aggtattaat ggaaagcttt     1200

ttgctgtgca ttcaatcttc atagaggtct gctttccaat tacattctct ttgttttaag     1260

tataactttg aaactcaaat ataaaagcct gctacttttt tttgttctaa aaagacagat     1320

gtggactagg cacctgtact gtgaaaccag aatagagaag ctgttgggca gatttgaaga     1380

ggattgagta atatagagaa tgtcttgaga tatttgtgaa gcttttattg ctttgttgca     1440

attgttgtct agaaacatgg gctttttctg ttttttctcc tattccagga gaggagggcg     1500

catcacttca gaaaaggaag agcagtgctc aaaagtgttg gatccggagc tactaacttc     1560

agcctgctga agcaggctgg agacgtggag gagaaccctg gacctatgct cgagggagtg     1620

caggtggaga ctatctcccc aggagacggg cgcaccttcc ccaagcgcgg ccagacctgc     1680

gtggtgcact acaccgggat gcttgaagat ggaaagaaag ttgattcctc ccgggacaga     1740

aacaagccct ttaagtttat gctaggcaag caggaggtga tccgaggctg ggaagaaggg     1800

gttgcccaga tgagtgtggg tcagagagcc aaactgacta tatctccaga ttatgcctat     1860

ggtgccactg ggcacccagg catcatccca ccacatgcca ctctcgtctt cgatgtggag     1920

cttctaaaac tggaatctgg cggtggttcc ggagtcgacg gatttggtga tgtcggtgct     1980

cttgagagtt tgaggggaaa tgcagatttg gcttacatcc tgagcatgga gccctgtggc     2040

cactgcctca ttatcaacaa tgtgaacttc tgccgtgagt ccgggctccg cacccgcact     2100

ggctccaaca tcgactgtga gaagttgcgg cgtcgcttct cctcgctgca tttcatggtg     2160

gaggtgaagg gcgacctgac tgccaagaaa atggtgctgg ctttgctgga gctggcgcgg     2220

caggaccacg gtgctctgga ctgctgcgtg gtggtcattc tctctcacgg ctgtcaggcc     2280

agccacctgc agttcccagg ggctgtctac ggcacagatg gatgccctgt gtcggtcgag     2340

aagattgtga acatcttcaa tgggaccagc tgccccagcc tgggagggaa gcccaagctc     2400

tttttcatcc aggcctgtgg tggggagcag aaagaccatg ggtttgaggt ggcctccact     2460

tcccctgaag acgagtcccc tggcagtaac cccgagccag atgccacccc gttccaggaa     2520

ggtttgagga ccttcgacca gctggacgcc atatctagtt tgcccacacc cagtgacatc     2580

tttgtgtcct actctacttt cccaggtttt gtttcctgga gggaccccaa gagtggctcc     2640

tggtacgttg agaccctgga cgacatcttt gagcagtggg ctcactctga agacctgcag     2700

tccctcctgc ttagggtcgc taatgctgtt tcggtgaaag ggatttataa acagatgcct     2760

ggttgcttta atttcctccg gaaaaaactt ttctttaaaa catcagtcga ctatccgtac     2820

gacgtaccag actacgcact cgacctcgac ggatccggag agggcagagg aagtctgcta     2880

acatgcggtg acgtcgagga gaatcctgga cctatggtga gcaagggcga ggagctgttc     2940

accggggtgg tgcccatcct ggtcgagctg gacggcgacg taaacggcca caagttcagc     3000

gtgtccggcg agggcgaggg cgatgccacc tacggcaagc tgaccctgaa gttcatctgc     3060

accaccggca agctgcccgt gccctggccc accctcgtga ccaccctgac ctacggcgtg     3120

cagtgcttca gccgctaccc cgaccacatg aagcagcacg acttcttcaa gtccgccatg     3180

cccgaaggct acgtccagga gcgcaccatc ttcttcaagg acgacggcaa ctacaagacc     3240

cgcgccgagg tgaagttcga gggcgacacc ctggtgaacc gcatcgagct gaagggcatc     3300

gacttcaagg aggacggcaa catcctgggg cacaagctgg agtacaacta caacagccac     3360

aacgtctata tcatggccga caagcagaag aacggcatca aggtgaactt caagatccgc     3420

cacaacatcg aggacggcag cgtgcagctc gccgaccact accagcagaa cacccccatc     3480

ggcgacggcc ccgtgctgct gcccgacaac cactacctga gcacccagtc cgccctgagc     3540

aaagacccca acgagaagcg cgatcacatg gtcctgctgg agttcgtgac cgccgccggg     3600

atcactctcg gcatggacga gctgtacaag tgatgaacaa agactttgaa gtacataaat     3660

gtattacttt gatgttaata cagttcagtt tagtaagatg tgtagtaaaa agtgtaacct     3720

tgttcaaaaa gttgcttcaa gttgatgttt gtgttctgtt ttacctgttc cagaatagct     3780

atttttgctt gagaagtttg aagttgtaag agttgaaata tttccaggtt ttattactag     3840

cttgcatgct tttcctgcta actaactgaa atgctaatct taaggaattt atatggggaa     3900

ggggaaaaaa gaaaaacact ttgtttggta cgtgtggatt ttcttctgag ctttaaggta     3960

cagtttgttg catgttaaaa tttagttctt attaaaccac aactttaagt tactaacgtc     4020

aaccagttac ctcttgcagt tcaaaagttg aagcagttcc ttgtccaaga tggagtattt     4080

taaaactgag ctcttaatca gtggaacaga agacgtcacg gtgtaactca actgaagccc     4140

tttaagtccc ggttctcttt agactaccta atcaatgtct ttgtttgcta acgacagttt     4200

atctatgtga atcctaaaat tcctatatgt aacttaagat gcaagaatgt aattagttac     4260

attggctgct cagtggagta tgactttttt ttttactgga ttaattttag caatacctgt     4320

atcttaaaat tgtgagaaaa tactgcattt aaaatatgcc taactttgtg atgcaatatg     4380

ttaatcaaag aatacatgta agcatatttt aataataatt atgtagattt tagtcatgta     4440

ttttgaaaca attaaaattt ttaattttga cttaccttcc cagtgtgagt gacatcctaa     4500

tataatactt ctaaatctta agctgctttg agaaaggcat gcagcgtatt tattgaagga     4560

attgaagatt tcttacccta cataagaatt ccagttagga caagtttata gcaacaaact     4620

ttcacatttg ctgttagttc tacctgcgat tttgaaggag tacaactgag aacagcactc     4680

agtcttgtat gtgtgttggg tcctagtctg attcattttt cttattacta cccttatacc     4740

tcagtctcca agtaaaaaag gaaataactc ctcctttgta gacgtgtata tgtgaatgaa     4800

tagaatggca tgtcccactt caaatgtcta gaagtagatg ttggtgaaac atgcaataag     4860

agctgagttg ctctgtacct ggatagtggg ctgtaagatg cagcacagga gtgtcccagg     4920

actgttgttc aggagtagga gtcaggggag ggaggcaggg cttgggggat agcaataata     4980

gttggtgccg ttctccataa aattactcag aagcaatgtt ctggcagcat aaatcgacct     5040

aaagttgtta actttttctc tgctcagacc gttccctagc actaaagatg ctgtgtcctt     5100

aagtgtgttt ccatactatc catcaccatg tttttcccaa cctattgctt taatagtatt     5160

g                                                                     5161


<210>  6
<211>  6579
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Left arm-GFP-2a-iCaspase9-T2a-Right arm

<400>  6
tttttttctt tgagatgagt atcttattgc agctctgtgc ataccccttg aaaatccgta       60

ggtgatgtat ttatgttgac tgaaaatgga gtcattcaaa aattgatgac ttcttccttt      120

tctcttttta atctcgaaac ctgttctcag attcctttat cagaacaaaa agcacggctg      180

catgtttttc accgttcaca cgactgtgtt tagccagcgt atctaaatgc ataacatgat      240

ttgccataac ttgagcctgc cataatcaga gcctcatttt gaaagctgtc atggtctgaa      300

acatagcatg ggtaagatga ttttcacctt gatgatgcat gtttaactca tttcaacgag      360

aggtcaaatc catccaaaaa tgctaaatct atcaaccagt tttcatgttc aagttctggc      420

acaaattttc gttctgactc catacgtgat tagatttcat tttgcaaatc atgaaaacta      480

ttgccaaaac atacaatttt aagtcagcag ttttactgcc caaatttgca caagcacatg      540

taacgtgaca gacaaaaacc cactggacag agacaaaata ctgggtttgg ccagtatggt      600

ttggctaagc cacgtttttc agggcaagaa ttgcctcacc tttttttata ttggaatcaa      660

attctcaagt gtaacagcct ggcgccatct cagctgccat taagtagcat gtgctgcaac      720

aagatgtcta ccacacactc tgctctgggt ggtgggggca caccagtgtg gacggcaacc      780

atgacacaag catagagtct tggcagaggt ccattgggtg catttatagt ggttcacact      840

ggggggttat cacagaatca tggaggttgg aaggtacctc cgggggtcat caaatccaac      900

cacttgacaa agcaggttcc ctaaagtaga ttgctcaaga acagtcacag cactgctgct      960

cacagaaaat ctctagttgg taaggttacc tttttttttg ttgtcgctcc cagttaaacc     1020

aaggtgggaa cacatccttt tcatagttgt attgtaggga tgtttatagc tattgctagg     1080

gaaaactgaa cagcgtgcaa ggaagtcagc actgacacag ctttcccacg tgagagagct     1140

atttcaaagc aagatcagca catatcccaa tctgtacttc ctcaaacaca gcccaaaacc     1200

gatagcaagg ccaagcagca gcactgctcc ttcaaggaaa ctgctgcata atctgaattt     1260

cagacggcag gaggaaacaa ggcagcagac tgatgaccta ccaccctgag tctcagctac     1320

atgcgatccg agccactcca actctgcttc ctgcagccct tccttcacgc tcatcttttg     1380

caccttaggc actcttataa ttcaagtact ttgtggcttt gggatatttg aagagcttgg     1440

tcagttagtc acaagtctgg ccacgtgcta tcatattagt ttgaaaagca atggagacac     1500

catctgctga tgctcaaagt ggttacaacc aaaacacaaa aaagcagagc tgtgggaaga     1560

attcaacatt ttgattatgc aagaagctag tcccagcctt gaaatccacc atctgcatca     1620

tgaaagacct aagtagttaa agccacagca gacatacagc ttctatttcc ttaccttctt     1680

catcattaac tacaggtctt ggaagatttt tgctgggaaa aagcttttat tgcaagaact     1740

gtaatttatt aacagggaaa catgaaataa atgtgtaaat tctcctgcac tcccactgtc     1800

attaaaaacg gctttaagaa agagtattca gtaactgcct gcattgtgtt gtgactttct     1860

actctgtgac acacagcctt ctgggcaaag cacatattct gccatgcatg tgggtcgtgc     1920

cttggaaaat gggaacccac attcactgag ggcctcttga tgagctttcc ccttgagaac     1980

agcgaggtct catggatatc ttctcttctc caagccaaat aagcccagat ccctcagctt     2040

tccttcatgg agaggctcca gccctctgat catgcctgca gcccttctct ggacctgctc     2100

cagcagcccc acacgctcct catgctggga ccccagatct gcacatggta ttgcacatgg     2160

ggcctcacaa cggcagagct gagagggaca attccctccc tcagccttta attctgcacg     2220

tacttaattt tgtctgtatt ttttttgcaa tagaatagcc tgcatgctag ttgctgtgtc     2280

gcacagctga attcactagg ttcctgtgaa acaaagggca atcccacagc cactgtagca     2340

cgtgaggagc cacacaggtg ctctaattcc tacaggacag gcctagggac agagcggccc     2400

taggactgcc ctcccgcacc tcctagcttc accttttgcc cgcgatcttt aagtaccctg     2460

aagcataaac agggaaagcg ccgcccgcag cctcaccctg cttcccgccc aacgcggcac     2520

cgcccaggcc gcagccgccc actaagagca ctagcgccac cttctcaccc cacccccacc     2580

acgcgttcct agcggccctg agagctgctg cgcatgcgcc gcctgacgat tcgccctccc     2640

attggctggc ggtcgaagca cggcgggggc acgcggtggc ggctatataa ggcgtctcgg     2700

aagacggcgc catgctattt ggagcggaga gtgaaagtta cagttcctgg tgctggtagg     2760

gagtgtggcg cggagcggag cgctgcggct catcggaacc acaatggagc catagcagag     2820

ccgggcgtgg gggcaagggc agtgcgtgct ggggagggct ccgtcgcgtg gccacgtcgc     2880

gagagccgtc gggatggtgg cgtcagggcg gggggtgctg ctaacgtgct cctggtcctg     2940

caggtgggct gctggcattc gccatggtga gcaagggcga ggagctgttc accggggtgg     3000

tgcccatcct ggtcgagctg gacggcgacg taaacggcca caagttcagc gtgtccggcg     3060

agggcgaggg cgatgccacc tacggcaagc tgaccctgaa gttcatctgc accaccggca     3120

agctgcccgt gccctggccc accctcgtga ccaccctgac ctacggcgtg cagtgcttca     3180

gccgctaccc cgaccacatg aagcagcacg acttcttcaa gtccgccatg cccgaaggct     3240

acgtccagga gcgcaccatc ttcttcaagg acgacggcaa ctacaagacc cgcgccgagg     3300

tgaagttcga gggcgacacc ctggtgaacc gcatcgagct gaagggcatc gacttcaagg     3360

aggacggcaa catcctgggg cacaagctgg agtacaacta caacagccac aacgtctata     3420

tcatggccga caagcagaag aacggcatca aggtgaactt caagatccgc cacaacatcg     3480

aggacggcag cgtgcagctc gccgaccact accagcagaa cacccccatc ggcgacggcc     3540

ccgtgctgct gcccgacaac cactacctga gcacccagtc cgccctgagc aaagacccca     3600

acgagaagcg cgatcacatg gtcctgctgg agttcgtgac cgccgccggg atcactctcg     3660

gcatggacga gctgtacaag ggatccggag ctactaactt cagcctgctg aagcaggctg     3720

gagacgtgga ggagaaccct ggacctatgc tcgagggagt gcaggtggag actatctccc     3780

caggagacgg gcgcaccttc cccaagcgcg gccagacctg cgtggtgcac tacaccggga     3840

tgcttgaaga tggaaagaaa gttgattcct cccgggacag aaacaagccc tttaagttta     3900

tgctaggcaa gcaggaggtg atccgaggct gggaagaagg ggttgcccag atgagtgtgg     3960

gtcagagagc caaactgact atatctccag attatgccta tggtgccact gggcacccag     4020

gcatcatccc accacatgcc actctcgtct tcgatgtgga gcttctaaaa ctggaatctg     4080

gcggtggatc cggagtcgac ggatttggtg atgtcggtgc tcttgagagt ttgaggggaa     4140

atgcagattt ggcttacatc ctgagcatgg agccctgtgg ccactgcctc attatcaaca     4200

atgtgaactt ctgccgtgag tccgggctcc gcacccgcac tggctccaac atcgactgtg     4260

agaagttgcg gcgtcgcttc tcctcgctgc atttcatggt ggaggtgaag ggcgacctga     4320

ctgccaagaa aatggtgctg gctttgctgg agctggcgcg gcaggaccac ggtgctctgg     4380

actgctgcgt ggtggtcatt ctctctcacg gctgtcaggc cagccacctg cagttcccag     4440

gggctgtcta cggcacagat ggatgccctg tgtcggtcga gaagattgtg aacatcttca     4500

atgggaccag ctgccccagc ctgggaggga agcccaagct ctttttcatc caggcctgtg     4560

gtggggagca gaaagaccat gggtttgagg tggcctccac ttcccctgaa gacgagtccc     4620

ctggcagtaa ccccgagcca gatgccaccc cgttccagga aggtttgagg accttcgacc     4680

agctggacgc catatctagt ttgcccacac ccagtgacat ctttgtgtcc tactctactt     4740

tcccaggttt tgtttcctgg agggacccca agagtggctc ctggtacgtt gagaccctgg     4800

acgacatctt tgagcagtgg gctcactctg aagacctgca gtccctcctg cttagggtcg     4860

ctaatgctgt ttcggtgaaa gggatttata aacagatgcc tggttgcttt aatttcctcc     4920

ggaaaaaact tttctttaaa acatcagtcg actatccgta cgacgtacca gactacgcac     4980

tcgacctcga cggatccgga gagggcagag gaagtctgct aacatgcggt gacgtcgagg     5040

agaatcctgg acctatggag gaggattggg ataccgaact cgagcaggag gcggcagcgg     5100

cttcccaggg gcgttctgag gagcaggcgt ggatggtgag ctgtgtccag gggagggcgg     5160

tgcggcaggg agcggggcac tgggatggcc cggtctggga aggggaggcc gagaggcctt     5220

cgcagtgctt cctgcagctc cccgagcagt gcgaagaagg aggtgccggg ctctgctgtg     5280

ggagccgaag gcacggagct gcctggggag ggaatggctg tgtgcctgag gtgccagaga     5340

ccggcaaggg ctgtacagag aggcaacggt tttgtgtaca aatcatttgt atgggaaacc     5400

acaaaatctt gaagctttat tacatggcag cgaaatactt tggtgtgaag taaaggataa     5460

gatagaggag tgtaatgaga gacagctaaa taatatttta ctacttgtgg gatgagtgaa     5520

tatcaggagg aactgctgta aatttcagga ggacctgttg tgaatcttca gtagttggcg     5580

ccgctcttac acatcttaca gatgcccctt gagcaaaggg ggataaggag agatgaacgg     5640

gttatccaaa caggtgatga gctaaaagta cagttgccta aagaagtagt agcatgtgct     5700

atcagaatga taattttgtt agtttggggt tagtttcctg tagtggtaga tagccacaac     5760

aagaaaaccg cttaagtttt tgtaaaacaa aaaaagcacg atccagaagt aaaaaatatg     5820

ggtagttttt tttgatgttc ctctctcacc tggtgctttg gcatactaat atgtgtctaa     5880

ttgtattaaa caggagaaat ttaaacctag gctttgctgg aaataaaatg ttacaatgct     5940

acaatgtgaa aagtaggtgc tattctgaac tgttttgggt ggagtatctg aatctttgaa     6000

taatttaaga gggactgaca tatttaaaat acttaaggat aatctgtagc catgctgtaa     6060

aagaacaaca gaaatgcagt tgggaaggtg atggaaatag ttttattcat gttactggtg     6120

gtctgaaacc tttctaagct taaactgtag aaaaaaattg cttcaaaaga ttgcactatt     6180

actttgggcg acaaatgttt ttaattggtt ttaagtgttt gttagcaaag tgaagttgat     6240

gccaccataa gtctgacagg aggcaagata aacttgtctt catactgctt gtgtataact     6300

tggttttgat gacatttgtg tgtgaacatt atgcacttca gtgtagcgaa gtttaagaaa     6360

ctttgaacag aataacttga aagagtgtgc acatgggtgc agaagtcact ttatttcagt     6420

tgggagactt agcacctaaa tgcactgtta gttcacatac actttgcttg gcctgaaggt     6480

aacattgtga tgtcgctttt tttccctgta ggctaactct ggcagaccaa acagcccatc     6540

cctccgcttc tccagcagac caagcagccc cttgtctgg                            6579


<210>  7
<211>  75
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  forward primer

<400>  7
cggtgacgtc gaggagaatc ctggacctat ggaggaggat tgggataccg aactcgagca       60

ggaggcggca gcggc                                                        75


<210>  8
<211>  47
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  reverse primer

<400>  8
gaaatccagc ttccagttcc cacctggcca gacaaggggc tgcttgg                     47


<210>  9
<211>  41
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  forward primer

<400>  9
ggtgggctgc tggcattcgc catggtgagc aagggcgagg a                           41


<210>  10
<211>  76
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  reverse primer

<400>  10
gattctcctc gacgtcaccg catgttagca gacttcctct gccctctccg gatcccttgt       60

acagctcgtc catgcc                                                       76


<210>  11
<211>  57
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  forward primer

<400>  11
tctcccatat ggtcgacctg caggcggccg cgaattcact agtgattctt cgtggtt          57


<210>  12
<211>  48
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  reverse primer

<400>  12
aggctgaagt tagtagctcc ggatccaaca cttttgagca ctgctctt                    48


<210>  13
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  forward primer

<400>  13
cagaacatca ccctgaccga ggtgggatcc ggagagggca gaggaagtct gctaacatgc       60

ggtgacgtcg aggagaatcc tggacctatg gtgagcaagg gcgagga                    107


<210>  14
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  reverse primer

<400>  14
cttgtacagc tcgtccatgc cg                                                22


<210>  15
<211>  94
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  forward primer

<400>  15
tctcggcatg gacgagctgt acaagtgatg aacaaagact ttgaagtaca taaatgtatt       60

actttgatgt taatacagtt cagtttagta agat                                   94


<210>  16
<211>  55
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  reverse primer

<400>  16
ctcttcgaaa tccagcttcc agttcccacc tggcaatact attaaagcaa taggt            55


<210>  17
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  guide sequence

<400>  17
ggtcctattc caggagagga                                                   20


<210>  18
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  guide sequence

<400>  18
ggcttactaa actgaactgt                                                   20


