                         SEQUENCE LISTING

<110>  Griffith University & University of Tartu
 
<120>  Virus vaccine

<130>  180987PCT

<160>  12    

<170>  PatentIn version 3.5

<210>  1
<211>  1050
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  ZIKV-DO-scattered vaccine candidate, computational codon 
       deoptimization of nonstructural ZIKV region NS3

<400>  1
caaagaagta aaaaaagggg agaccacgga tggagtatac agagtaatga cgcgtagact       60

gctaggttcg acacaagttg gtgtaggagt tatgcaagaa ggggtctttc atactatgtg      120

gcatgtcaca aaaggttccg cgctgcgtag cggtgaaggt agacttgatc cgtactgggg      180

agatgtaaag caggatctag tatcatactg tggtccgtgg aagctagatg cggcctggga      240

cggtcacagc gaggtacagc tcttggcggt accccccgga gaaagagcga ggaatatcca      300

gactctaccc ggaatattta aaacaaagga tggtgacatt ggagcggtag cgctggatta      360

tccagcagga acgtcaggat ctccgatcct agacaaatgt gggagagtaa taggacttta      420

tggtaatggg gtcgtaatca aaaatggtag ttatgttagt gcgatcaccc aaggtaggag      480

ggaagaagaa actcctgttg aatgcttcga gccgtcgatg ctgaaaaaga agcagctaac      540

ggtcttagac ttacatcctg gagcggggaa aacccgaaga gttcttccgg aaatagtccg      600

tgaagcgata aaaacacgtc tccgtactgt aatcttagct ccgaccaggg ttgtagctgc      660

tgaaatggaa gaggcccttc gtgggcttcc agtacgttat atgacgacag cagtcaatgt      720

aacccactct ggtacagaaa tcgttgactt aatgtgtcat gccaccttta cttcacgtct      780

actacaacca atcagagttc ccaactataa tctatatatt atggatgaag cccacttcac      840

ggatccctca agtatagcgg caagaggata tatttcaaca agggttgaaa tgggcgaggc      900

ggcggccatc ttcatgacgg ccacgccacc gggaacccgt gatgcatttc cggattccaa      960

ctcaccgatt atggacacgg aagtggaagt tccagagaga gcgtggagct caggttttga     1020

ttgggtaacg gatcattcgg gaaaaacagt                                      1050


<210>  2
<211>  7890
<212>  DNA
<213>  Zika virus wt region NS1 to NS5

<400>  2
gatgtggggt gctcggtgga cttctcaaag aaggagacga gatgcggtac aggggtgttc       60

gtctataacg acgttgaagc ctggagggac aggtacaagt accatcctga ctccccccgt      120

agattggcag cagcagtcaa gcaagcctgg gaagatggta tctgcgggat ctcctctgtt      180

tcaagaatgg aaaacatcat gtggagatca gtagaagggg agctcaacgc aatcctggaa      240

gagaatggag ttcaactgac ggtcgttgtg ggatctgtaa aaaaccccat gtggagaggt      300

ccacagagat tgcccgtgcc tgtgaacgag ctgccccacg gctggaaggc ttgggggaaa      360

tcgtacttcg tcagagcagc aaagacaaat aacagctttg tcgtggatgg tgacacactg      420

aaggaatgcc cactcaaaca tagagcatgg aacagctttc ttgtggagga tcatgggttc      480

ggggtatttc acactagtgt ctggctcaag gttagagaag attattcatt agagtgtgat      540

ccagccgtta ttggaacagc tgttaaggga aaggaggctg tacacagtga tctaggctac      600

tggattgaga gtgagaagaa tgacacatgg aggctgaaga gggcccatct gatcgagatg      660

aaaacatgtg aatggccaaa gtcccacaca ttgtggacag atggaataga agagagtgat      720

ctgatcatac ccaagtcttt agctgggcca ctcagccatc acaataccag agagggctac      780

aggacccaaa tgaaagggcc atggcacagt gaagagcttg aaattcggtt tgaggaatgc      840

ccaggcacta aggtccacgt ggaggaaaca tgtggaacaa gaggaccatc tctgagatca      900

accactgcaa gcggaagggt gatcgaggaa tggtgctgca gggagtgcac aatgccccca      960

ctgtcgttcc gggctaaaga tggctgttgg tatggaatgg agataaggcc caggaaagaa     1020

ccagaaagca acttagtaag gtcaatggtg actgcaggat caactgatca catggaccac     1080

ttctcccttg gagtgcttgt gatcctgctc atggtgcagg aagggctgaa gaagagaatg     1140

accacaaaga tcatcataag cacatcaatg gcagtgctgg tagctatgat cctgggagga     1200

ttttcaatga gtgacctggc taagcttgca attttgatgg gtgccacctt cgcggaaatg     1260

aacactggag gagatgtagc tcatctggcg ctgatagcgg cattcaaagt cagaccagcg     1320

ttgctggtat ctttcatctt cagagctaat tggacacccc gtgaaagcat gctgctggcc     1380

ttggcctcgt gtcttttgca aactgcgatc tccgccttgg aaggcgacct gatggttctc     1440

atcaatggtt ttgctttggc ctggttggca atacgagcga tggttgttcc acgcactgat     1500

aacatcacct tggcaatcct ggctgctctg acaccactgg cccggggcac actgcttgtg     1560

gcgtggagag caggccttgc tacttgcggg gggtttatgc tcctctctct gaagggaaaa     1620

ggcagtgtga agaagaactt accatttgtc atggccctgg gactaaccgc tgtgaggctg     1680

gtcgacccca tcaacgtggt gggactgctg ttactcacaa ggagtgggaa gcggagctgg     1740

ccccctagcg aagtactcac agctgttggc ctgatatgcg cattggctgg agggttcgcc     1800

aaggcagata tagagatggc tgggcccatg gccgcggtcg gtctgctaat tgtcagttac     1860

gtggtctcag gaaagagtgt ggacatgtac attgaaagag caggtgacat cacatgggaa     1920

aaagatgcgg aagtcactgg aaacagtccc cggctcgatg tggcgctaga tgagagtggt     1980

gatttctccc tggtggagga tgacggtccc cccatgagag agatcatact caaggtggtc     2040

ctgatgacca tctgtggcat gaatccaata gccataccct ttgcagctgg agcgtggtac     2100

gtatacgtga agactggaaa aaggagtggt gctctatggg atgtgcctgc tcccaaggaa     2160

gtaaaaaagg gggagaccac agatggagtg tacagagtaa tgactcgtag actgctaggt     2220

tcaacacaag ttggagtggg agttatgcaa gagggggtct ttcacactat gtggcacgtc     2280

acaaaaggat ccgcgctgag aagcggtgaa gggagacttg atccatactg gggagatgtc     2340

aagcaggatc tggtgtcata ctgtggtcca tggaagctag atgccgcctg ggacgggcac     2400

agcgaggtgc agctcttggc cgtgcccccc ggagagagag cgaggaacat ccagactctg     2460

cccggaatat ttaagacaaa ggatggggac attggagcgg ttgcgctgga ttacccagca     2520

ggaacttcag gatctccaat cctagacaag tgtgggagag tgataggact ttatggcaat     2580

ggggtcgtga tcaaaaatgg gagttatgtt agtgccatca cccaagggag gagggaagaa     2640

gagactcctg ttgagtgctt cgagccctcg atgctgaaga agaagcagct aactgtctta     2700

gacttgcatc ctggagctgg gaaaaccagg agagttcttc ctgaaatagt ccgtgaagcc     2760

ataaaaacaa gactccgtac tgtgatctta gctccaacca gggttgtcgc tgctgaaatg     2820

gaggaggccc ttagagggct tccagtgcgt tatatgacaa cagcagtcaa tgtcacccac     2880

tctggaacag aaatcgtcga cttaatgtgc catgccacct tcacttcacg tctactacag     2940

ccaatcagag tccccaacta taatctgtat attatggatg aggcccactt cacagatccc     3000

tcaagtatag cagcaagagg atacatttca acaagggttg agatgggcga ggcggctgcc     3060

atcttcatga ccgccacgcc accaggaacc cgtgacgcat ttccggactc caactcacca     3120

attatggaca ccgaagtgga agtcccagag agagcctgga gctcaggctt tgattgggtg     3180

acggatcatt ctggaaaaac agtttggttt gttccaagcg tgaggaacgg caatgagatc     3240

gcagcttgtc tgacaaaggc tggaaaacgg gtcatacagc tcagcagaaa gacttttgag     3300

acagagttcc agaaaacaaa acatcaagag tgggactttg tcgtgacaac tgacatttca     3360

gagatgggcg ccaactttaa agctgaccgt gtcatagatt ccaggagatg cctaaagccg     3420

gtcatacttg atggcgagag agtcattctg gctggaccca tgcctgtcac acatgccagc     3480

gctgcccaga ggagggggcg cataggcagg aatcccaaca aacctggaga tgagtatctg     3540

tatggaggtg ggtgcgcaga gactgacgaa gaccatgcac actggcttga agcaagaatg     3600

ctccttgaca atatttacct ccaagatggc ctcatagcct cgctctatcg acctgaggcc     3660

gacaaagtag cagccattga gggagagttc aagcttagga cggagcaaag gaagaccttt     3720

gtggaactca tgaaaagagg agatcttcct gtttggctgg cctatcaggt tgcatctgcc     3780

ggaataacct acacagatag aagatggtgc tttgatggca cgaccaacaa caccataatg     3840

gaagatagtg tgccggcaga ggtgtggacc agacacggag agaaaagagt gctcaaaccg     3900

aggtggatgg acgccagagt ttgttcagat catgcggccc tgaagtcatt caaggagttt     3960

gccgctggga aaagaggagc ggcttttgga gtgatggaag ccctgggaac actgccagga     4020

cacatgacag agagattcca ggaagccatt gacaacctcg ctgtgctcat gcgggcagag     4080

actggaagca ggccttacaa agccgcggcg gcccaattgc cggagaccct agagaccata     4140

atgcttttgg ggttgctggg aacagtctcg ctgggaatct tcttcgtctt gatgaggaac     4200

aagggcatag ggaagatggg ctttggaatg gtgactcttg gggccagcgc atggctcatg     4260

tggctctcgg aaattgagcc agccagaatt gcatgtgtcc tcattgttgt gttcctattg     4320

ctggtggtgc tcatacctga gccagaaaag caaagatctc cccaggacaa ccaaatggca     4380

atcatcatca tggtagcagt aggtcttctg ggcttgatta ccgccaatga actcggatgg     4440

ttggagagaa caaagagtga cctaagccat ctaatgggaa ggagagagga gggggcaacc     4500

ataggattct caatggacat tgacctgcgg ccagcctcag cttgggccat ctatgctgcc     4560

ttgacaactt tcattacccc agccgtccaa catgcagtga ccacctcata caacaactac     4620

tccttaatgg cgatggccac gcaagctgga gtgttgtttg gtatgggcaa agggatgcca     4680

ttctacgcat gggactttgg agtcccgctg ctaatgatag gttgctactc acaattaaca     4740

cccctgaccc taatagtggc catcattttg ctcgtggcgc actacatgta cttgatccca     4800

gggctgcagg cagcagctgc gcgtgctgcc cagaagagaa cggcagctgg catcatgaag     4860

aaccctgttg tggatggaat agtggtgact gacattgaca caatgacaat tgacccccaa     4920

gtggagaaaa agatgggaca ggtgctactc atagcagtag ccgtctccag cgccatactg     4980

tcgcggaccg cctgggggtg gggggaggct ggggccctga tcacagccgc aacttccact     5040

ttgtgggaag gctctccgaa caagtactgg aactcctcta cagccacttc actgtgtaac     5100

atttttaggg gaagttactt ggctggagct tctctaatct acacagtaac aagaaacgct     5160

ggcttggtca agagacgtgg gggtggaaca ggagagaccc tgggagagaa atggaaggcc     5220

cgcttgaacc agatgtcggc cctggagttc tactcctaca aaaagtcagg catcaccgag     5280

gtgtgcagag aagaggcccg ccgcgccctc aaggacggtg tggcaacggg aggccatgct     5340

gtgtcccgag gaagtgcaaa gctgagatgg ttggtggagc ggggatacct gcagccctat     5400

ggaaaggtca ttgatcttgg atgtggcaga gggggctgga gttactacgc cgccaccatc     5460

cgcaaagttc aagaagtgaa aggatacaca aaaggaggcc ctggtcatga agaacccgtg     5520

ttggtgcaaa gctatgggtg gaacatagtc cgtcttaaga gtggggtgga cgtctttcat     5580

atggcggctg agccgtgtga cacgctgctg tgtgacatag gtgagtcatc atctagtcct     5640

gaagtggaag aagcacggac gctcagagtc ctctccatgg tgggggattg gcttgaaaaa     5700

agaccaggag ccttttgtat aaaagtgttg tgcccataca ccagcactat gatggaaacc     5760

ctggagcgac tgcagcgtag gtatggggga ggactggtca gagtgccact ctcccgcaac     5820

tctacacatg agatgtactg ggtctctgga gcgaaaagca acaccataaa aagtgtgtcc     5880

accacgagcc agctcctctt ggggcgcatg gacgggccta gaaggccagt gaaatatgag     5940

gaggatgtga atctcggctc tggcacgcgg gctgtggtaa gctgcgctga agctcccaac     6000

atgaagatca ttggtaaccg cattgaaagg atccgcagtg agcacgcgga aacgtggttc     6060

tttgacgaga accacccata taggacatgg gcttaccatg gaagctatga ggcccccaca     6120

caagggtcag cgtcctctct aataaacggg gttgtcaggc tcctgtcaaa accctgggat     6180

gtggtgactg gagtcacagg aatagccatg accgacacca caccgtatgg tcagcaaaga     6240

gttttcaagg aaaaagtgga cactagggtg ccagaccccc aagaaggcac tcgtcaggtt     6300

atgagcatgg tctcttcctg gttgtggaaa gagctaggca aacacaaacg gccacgagtc     6360

tgtaccaaag aagagttcat caacaaggtt cgtagcaatg cagcattagg ggcaatattt     6420

gaagaggaaa aagagtggaa gactgcagtg gaagctgtga acgatccaag gttctgggct     6480

ctagtggaca aggaaagaga gcaccacctg agaggagagt gccagagttg tgtgtataac     6540

atgatgggaa aaagagaaaa gaaacaaggg gaatttggaa aggccaaggg cagccgcgcc     6600

atctggtata tgtggctagg ggctagattt ctagagttcg aagcccttgg attcttgaac     6660

gaggatcact ggatggggag agagaactca ggaggtggtg ttgaagggct gggattacaa     6720

agactcggat atgtcctaga agagatgagt cgtataccag gaggaaggat gtatgcagat     6780

gacactgctg gctgggacac ccgcattagc aggtttgatc tggagaatga agctctaatc     6840

accaaccaaa tggagaaagg gcacagggcc ttggcattgg ccataatcaa gtacacatac     6900

caaaacaaag tggtaaaggt ccttagacca gctgaaaaag ggaaaacagt tatggacatt     6960

atttcgagac aagaccaaag ggggagcgga caagttgtca cttacgctct taacacattt     7020

accaacctag tggtgcaact cattcggaat atggaggctg aggaagttct agagatgcaa     7080

gacttgtggc tgctgcggag gtcagagaaa gtgaccaact ggttgcagag caacggatgg     7140

gataggctca aacgaatggc agtcagtgga gatgattgcg ttgtgaagcc aattgatgat     7200

aggtttgcac atgccctcag gttcttgaat gatatgggaa aagttagaaa ggacacacaa     7260

gagtggaaac cctcaactgg atgggacaac tgggaagaag ttccgttttg ctcccaccac     7320

ttcaacaagc tccatctcaa ggacgggagg tccattgtgg ttccctgccg ccaccaagat     7380

gaactgattg gccgggcccg cgtctctcca ggggcgggat ggagcatccg ggagactgct     7440

tgcctagcaa aatcatatgc gcagatgtgg cagctccttt atttccacag aagggacctc     7500

cgactgatgg ccaatgccat ttgttcatct gtgccagttg actgggttcc aactgggaga     7560

actacctggt caatccatgg aaagggagaa tggatgacca ctgaagacat gcttgtggtg     7620

tggaacagag tgtggattga ggagaacgac cacatggaag acaagacccc agttacgaaa     7680

tggacagaca ttccctattt gggaaaaagg gaagacttgt ggtgtggatc tctcataggg     7740

cacagaccgc gcaccacctg ggctgagaac attaaaaaca cagtcaacat ggtgcgcagg     7800

atcataggtg atgaagaaaa gtacatggac tacctatcca cccaagttcg ctacttgggt     7860

gaagaagggt ctacacctgg agtgctgtaa                                      7890


<210>  3
<211>  1851
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Vaccine candidate ZIKV-DO-NS3 nonstructural region nucleotide 
       sequence, showing the codon deoptimized NS3 region

<400>  3
agtggtgcgc tctgggatgt ccccgcgccc aaggaagtaa aaaagggtga gaccacggat       60

ggcgtctacc gagtaatgac ccgtcgacta ctcggttcga cgcaagtagg cgtcggcgta      120

atgcaagagg gtgtattcca caccatgtgg catgtaacga aaggctcggc gctacgatcc      180

ggtgaaggtc gattggatcc gtactggggc gatgtaaagc aagatctagt ctcgtactgt      240

ggtccgtgga agctcgatgc cgcctgggac ggtcactccg aggtccagtt attggccgtc      300

cccccgggcg agcgagcgcg caatatacaa actctacccg gcatattcaa gacgaaggat      360

ggtgacattg gcgcggtagc gctagattac ccggcgggca cttcgggctc gccgatactc      420

gacaagtgtg gtcgagtcat aggcttgtat ggtaatggtg tagtcataaa aaatggtagt      480

tatgtaagtg ccataaccca aggtcgccgc gaagaagaga cccccgtaga gtgcttcgag      540

ccctcgatgc taaagaagaa gcaactcact gtattagact tgcatcccgg cgcgggtaaa      600

acccgccgag tattgcccga aatagtacgt gaagccataa aaacgcgatt acgtaccgtc      660

atattagcgc cgacccgcgt agtagcggcg gaaatggagg aggccttgcg aggtttgccg      720

gtccgttata tgacgacggc ggtaaatgta acccattcgg gcacggaaat agtagactta      780

atgtgccatg ccaccttcac ctcgcgtctc ctccagccga tacgagtacc caattataat      840

ctatatatta tggatgaggc ccatttcacg gatccctcga gtatagcggc gcgaggctac      900

atttcgacgc gcgtagagat gggtgaggcg gcggccatat tcatgaccgc cacgccgccg      960

ggcacccgtg acgcgttccc ggactcgaat tcgccgatta tggacaccga agtcgaagta     1020

ccggagcgag cctggtcctc gggttttgat tgggtcacgg atcattcggg caaaacggta     1080

tggttcgtac cgtccgtccg caatggtaat gagatagcgg cgtgtctaac gaaggcgggc     1140

aaacgggtaa tacagttatc ccgaaagacc ttcgagacgg agttccaaaa aacgaaacat     1200

caagagtggg acttcgtagt cacgaccgac atttcggaga tgggtgccaa tttcaaagcg     1260

gaccgtgtaa tagattcgcg ccgatgcctc aagccggtaa tattggatgg tgagcgagta     1320

attctagcgg gccccatgcc cgtaacgcat gcctccgcgg cccaacgccg cggtcgcata     1380

ggtcgcaatc ccaataaacc cggcgatgag tatctatatg gcggtggttg cgcggagacc     1440

gacgaagacc atgcgcattg gttggaagcg cgaatgttat tggacaatat ttacttacaa     1500

gatggtttaa tagcctcgtt atatcgaccc gaggccgaca aagtagcggc cattgagggc     1560

gagttcaagt tgcgcacgga gcaacgcaag accttcgtcg aattaatgaa acgaggcgat     1620

ttgcccgtat ggctagccta tcaagtagcg tcggccggca taacctacac ggatcgacga     1680

tggtgcttcg atggtacgac caataatacc ataatggaag atagtgtgcc ggcagaggtg     1740

tggaccagac acggagagaa aagagtgctc aaaccgaggt ggatggacgc cagagtttgt     1800

tcagatcatg cggccctgaa gtcattcaag gagtttgccg ctgggaaaag a              1851


<210>  4
<211>  1851
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Vaccine candidate ZIKV-DO-NS3 nonstructural region nucleotide 
       sequence, showing the entire codon deoptimized NS3 region

<400>  4
agtggtgcgc tctgggatgt ccccgcgccc aaggaagtaa aaaagggtga gaccacggat       60

ggcgtctacc gagtaatgac ccgtcgacta ctcggttcga cgcaagtagg cgtcggcgta      120

atgcaagagg gtgtattcca caccatgtgg catgtaacga aaggctcggc gctacgatcc      180

ggtgaaggtc gattggatcc gtactggggc gatgtaaagc aagatctagt ctcgtactgt      240

ggtccgtgga agctcgatgc cgcctgggac ggtcactccg aggtccagtt attggccgtc      300

ccgccgggcg agcgagcgcg caatatacaa actctacccg gcatattcaa gacgaaggat      360

ggtgacattg gcgcggtagc gctagattac ccggcgggca cttcgggctc gccgatactc      420

gacaagtgtg gtcgagtcat aggcttgtat ggtaatggtg tagtcataaa aaatggtagt      480

tatgtaagtg ccataaccca aggtcgccgc gaagaagaga cccccgtaga gtgcttcgag      540

ccctcgatgc taaagaagaa gcaactcact gtattagact tgcatcccgg cgcgggtaaa      600

acccgccgag tattgcccga aatagtacgt gaagccataa aaacgcgatt acgtaccgtc      660

atattagcgc cgacccgcgt agtagcggcg gaaatggagg aggccttgcg aggtttgcca      720

gtccgttata tgacgacggc ggtaaatgta acccattcgg gcacggaaat agtagactta      780

atgtgccatg ccaccttcac ctcgcgtctc ctccagccga tacgagtacc caattataat      840

ctatatatta tggatgaggc ccatttcacg gatccctcga gtatagcggc gcgaggctac      900

atttcgacgc gcgtagagat gggtgaggcg gcggccatat tcatgaccgc cacgccgccg      960

ggcacccgtg acgcgttccc ggactcgaat tcgccgatta tggacaccga agtcgaagta     1020

ccggagcgag cctggtcctc gggttttgat tgggtcacgg atcattcggg caaaacggta     1080

tggttcgtac cgtccgtccg caatggtaat gagatagcgg cgtgtctaac gaaggcgggc     1140

aaacgggtaa tacagttatc ccgaaagacc ttcgagacgg agttccaaaa aacgaaacat     1200

caagagtggg acttcgtagt cacgaccgac atttcggaga tgggtgccaa tttcaaagca     1260

gaccgtgtaa tagattcgcg ccgatgcctc aagccggtaa tattggatgg tgagcgagta     1320

attctagcgg gccccatgcc cgtaacgcat gcctccgcgg cccaacgccg cggtcgcata     1380

ggtcgcaatc ccaataaacc cggcgatgag tatctatatg gcggtggttg cgcggagacc     1440

gacgaagacc atgcgcattg gttggaagcg cgaatgttat tggacaatat ttacttacaa     1500

gatggtttaa tagcctcgtt atatcgaccc gaggccgaca aagtagcggc cattgagggc     1560

gagttcaagt tgcgcacgga gcaacgcaag accttcgtcg aattaatgaa acgaggcgat     1620

ttgcccgtat ggctagccta tcaagtagcg tcggcaggta taacctacac ggatcgacga     1680

tggtgcttcg atggtacgac caataatacc ataatggaag atagtgtgcc ggcagaggtg     1740

tggaccagac acggagagaa aagagtgctc aaaccgaggt ggatggacgc cagagtttgt     1800

tcagatcatg cggccctgaa gtcattcaag gagtttgccg ctgggaaaag a              1851


<210>  5
<211>  7890
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  The entire NS3 region of vaccine candidate ZIKV-DO-NS3 is shown 
       together with all flanking nonstructural regions (NS1 to NS5)

<400>  5
gatgtggggt gctcggtgga cttctcaaag aaggagacga gatgcggtac aggggtgttc       60

gtctataacg acgttgaagc ctggagggac aggtacaagt accatcctga ctccccccgt      120

agattggcag cagcagtcaa gcaagcctgg gaagatggta tctgcgggat ctcctctgtt      180

tcaagaatgg aaaacatcat gtggagatca gtagaagggg agctcaacgc aatcctggaa      240

gagaatggag ttcaactgac ggtcgttgtg ggatctgtaa aaaaccccat gtggagaggt      300

ccacagagat tgcccgtgcc tgtgaacgag ctgccccacg gctggaaggc ttgggggaaa      360

tcgtacttcg tcagagcagc aaagacaaat aacagctttg tcgtggatgg tgacacactg      420

aaggaatgcc cactcaaaca tagagcatgg aacagctttc ttgtggagga tcatgggttc      480

ggggtatttc acactagtgt ctggctcaag gttagagaag attattcatt agagtgtgat      540

ccagccgtta ttggaacagc tgttaaggga aaggaggctg tacacagtga tctaggctac      600

tggattgaga gtgagaagaa tgacacatgg aggctgaaga gggcccatct gatcgagatg      660

aaaacatgtg aatggccaaa gtcccacaca ttgtggacag atggaataga agagagtgat      720

ctgatcatac ccaagtcttt agctgggcca ctcagccatc acaataccag agagggctac      780

aggacccaaa tgaaagggcc atggcacagt gaagagcttg aaattcggtt tgaggaatgc      840

ccaggcacta aggtccacgt ggaggaaaca tgtggaacaa gaggaccatc tctgagatca      900

accactgcaa gcggaagggt gatcgaggaa tggtgctgca gggagtgcac aatgccccca      960

ctgtcgttcc gggctaaaga tggctgttgg tatggaatgg agataaggcc caggaaagaa     1020

ccagaaagca acttagtaag gtcaatggtg actgcaggat caactgatca catggaccac     1080

ttctcccttg gagtgcttgt gatcctgctc atggtgcagg aagggctgaa gaagagaatg     1140

accacaaaga tcatcataag cacatcaatg gcagtgctgg tagctatgat cctgggagga     1200

ttttcaatga gtgacctggc taagcttgca attttgatgg gtgccacctt cgcggaaatg     1260

aacactggag gagatgtagc tcatctggcg ctgatagcgg cattcaaagt cagaccagcg     1320

ttgctggtat ctttcatctt cagagctaat tggacacccc gtgaaagcat gctgctggcc     1380

ttggcctcgt gtcttttgca aactgcgatc tccgccttgg aaggcgacct gatggttctc     1440

atcaatggtt ttgctttggc ctggttggca atacgagcga tggttgttcc acgcactgat     1500

aacatcacct tggcaatcct ggctgctctg acaccactgg cccggggcac actgcttgtg     1560

gcgtggagag caggccttgc tacttgcggg gggtttatgc tcctctctct gaagggaaaa     1620

ggcagtgtga agaagaactt accatttgtc atggccctgg gactaaccgc tgtgaggctg     1680

gtcgacccca tcaacgtggt gggactgctg ttactcacaa ggagtgggaa gcggagctgg     1740

ccccctagcg aagtactcac agctgttggc ctgatatgcg cattggctgg agggttcgcc     1800

aaggcagata tagagatggc tgggcccatg gccgcggtcg gtctgctaat tgtcagttac     1860

gtggtctcag gaaagagtgt ggacatgtac attgaaagag caggtgacat cacatgggaa     1920

aaagatgcgg aagtcactgg aaacagtccc cggctcgatg tggcgctaga tgagagtggt     1980

gatttctccc tggtggagga tgacggtccc cccatgagag agatcatact caaggtggtc     2040

ctgatgacca tctgtggcat gaatccaata gccataccct ttgcagctgg agcgtggtac     2100

gtatacgtga agactggaaa aaggagtggt gcgctctggg atgtccccgc gcccaaggaa     2160

gtaaaaaagg gtgagaccac ggatggcgtc taccgagtaa tgacccgtcg actactcggt     2220

tcgacgcaag taggcgtcgg cgtaatgcaa gagggtgtat tccacaccat gtggcatgta     2280

acgaaaggct cggcgctacg atccggtgaa ggtcgattgg atccgtactg gggcgatgta     2340

aagcaagatc tagtctcgta ctgtggtccg tggaagctcg atgccgcctg ggacggtcac     2400

tccgaggtcc agttattggc cgtcccgccg ggcgagcgag cgcgcaatat acaaactcta     2460

cccggcatat tcaagacgaa ggatggtgac attggcgcgg tagcgctaga ttacccggcg     2520

ggcacttcgg gctcgccgat actcgacaag tgtggtcgag tcataggctt gtatggtaat     2580

ggtgtagtca taaaaaatgg tagttatgta agtgccataa cccaaggtcg ccgcgaagaa     2640

gagacccccg tagagtgctt cgagccctcg atgctaaaga agaagcaact cactgtatta     2700

gacttgcatc ccggcgcggg taaaacccgc cgagtattgc ccgaaatagt acgtgaagcc     2760

ataaaaacgc gattacgtac cgtcatatta gcgccgaccc gcgtagtagc ggcggaaatg     2820

gaggaggcct tgcgaggttt gccagtccgt tatatgacga cggcggtaaa tgtaacccat     2880

tcgggcacgg aaatagtaga cttaatgtgc catgccacct tcacctcgcg tctcctccag     2940

ccgatacgag tacccaatta taatctatat attatggatg aggcccattt cacggatccc     3000

tcgagtatag cggcgcgagg ctacatttcg acgcgcgtag agatgggtga ggcggcggcc     3060

atattcatga ccgccacgcc gccgggcacc cgtgacgcgt tcccggactc gaattcgccg     3120

attatggaca ccgaagtcga agtaccggag cgagcctggt cctcgggttt tgattgggtc     3180

acggatcatt cgggcaaaac ggtatggttc gtaccgtccg tccgcaatgg taatgagata     3240

gcggcgtgtc taacgaaggc gggcaaacgg gtaatacagt tatcccgaaa gaccttcgag     3300

acggagttcc aaaaaacgaa acatcaagag tgggacttcg tagtcacgac cgacatttcg     3360

gagatgggtg ccaatttcaa agcagaccgt gtaatagatt cgcgccgatg cctcaagccg     3420

gtaatattgg atggtgagcg agtaattcta gcgggcccca tgcccgtaac gcatgcctcc     3480

gcggcccaac gccgcggtcg cataggtcgc aatcccaata aacccggcga tgagtatcta     3540

tatggcggtg gttgcgcgga gaccgacgaa gaccatgcgc attggttgga agcgcgaatg     3600

ttattggaca atatttactt acaagatggt ttaatagcct cgttatatcg acccgaggcc     3660

gacaaagtag cggccattga gggcgagttc aagttgcgca cggagcaacg caagaccttc     3720

gtcgaattaa tgaaacgagg cgatttgccc gtatggctag cctatcaagt agcgtcggca     3780

ggtataacct acacggatcg acgatggtgc ttcgatggta cgaccaataa taccataatg     3840

gaagatagtg tgccggcaga ggtgtggacc agacacggag agaaaagagt gctcaaaccg     3900

aggtggatgg acgccagagt ttgttcagat catgcggccc tgaagtcatt caaggagttt     3960

gccgctggga aaagaggagc ggcttttgga gtgatggaag ccctgggaac actgccagga     4020

cacatgacag agagattcca ggaagccatt gacaacctcg ctgtgctcat gcgggcagag     4080

actggaagca ggccttacaa agccgcggcg gcccaattgc cggagaccct agagaccata     4140

atgcttttgg ggttgctggg aacagtctcg ctgggaatct tcttcgtctt gatgaggaac     4200

aagggcatag ggaagatggg ctttggaatg gtgactcttg gggccagcgc atggctcatg     4260

tggctctcgg aaattgagcc agccagaatt gcatgtgtcc tcattgttgt gttcctattg     4320

ctggtggtgc tcatacctga gccagaaaag caaagatctc cccaggacaa ccaaatggca     4380

atcatcatca tggtagcagt aggtcttctg ggcttgatta ccgccaatga actcggatgg     4440

ttggagagaa caaagagtga cctaagccat ctaatgggaa ggagagagga gggggcaacc     4500

ataggattct caatggacat tgacctgcgg ccagcctcag cttgggccat ctatgctgcc     4560

ttgacaactt tcattacccc agccgtccaa catgcagtga ccacctcata caacaactac     4620

tccttaatgg cgatggccac gcaagctgga gtgttgtttg gtatgggcaa agggatgcca     4680

ttctacgcat gggactttgg agtcccgctg ctaatgatag gttgctactc acaattaaca     4740

cccctgaccc taatagtggc catcattttg ctcgtggcgc actacatgta cttgatccca     4800

gggctgcagg cagcagctgc gcgtgctgcc cagaagagaa cggcagctgg catcatgaag     4860

aaccctgttg tggatggaat agtggtgact gacattgaca caatgacaat tgacccccaa     4920

gtggagaaaa agatgggaca ggtgctactc atagcagtag ccgtctccag cgccatactg     4980

tcgcggaccg cctgggggtg gggggaggct ggggccctga tcacagccgc aacttccact     5040

ttgtgggaag gctctccgaa caagtactgg aactcctcta cagccacttc actgtgtaac     5100

atttttaggg gaagttactt ggctggagct tctctaatct acacagtaac aagaaacgct     5160

ggcttggtca agagacgtgg gggtggaaca ggagagaccc tgggagagaa atggaaggcc     5220

cgcttgaacc agatgtcggc cctggagttc tactcctaca aaaagtcagg catcaccgag     5280

gtgtgcagag aagaggcccg ccgcgccctc aaggacggtg tggcaacggg aggccatgct     5340

gtgtcccgag gaagtgcaaa gctgagatgg ttggtggagc ggggatacct gcagccctat     5400

ggaaaggtca ttgatcttgg atgtggcaga gggggctgga gttactacgc cgccaccatc     5460

cgcaaagttc aagaagtgaa aggatacaca aaaggaggcc ctggtcatga agaacccgtg     5520

ttggtgcaaa gctatgggtg gaacatagtc cgtcttaaga gtggggtgga cgtctttcat     5580

atggcggctg agccgtgtga cacgctgctg tgtgacatag gtgagtcatc atctagtcct     5640

gaagtggaag aagcacggac gctcagagtc ctctccatgg tgggggattg gcttgaaaaa     5700

agaccaggag ccttttgtat aaaagtgttg tgcccataca ccagcactat gatggaaacc     5760

ctggagcgac tgcagcgtag gtatggggga ggactggtca gagtgccact ctcccgcaac     5820

tctacacatg agatgtactg ggtctctgga gcgaaaagca acaccataaa aagtgtgtcc     5880

accacgagcc agctcctctt ggggcgcatg gacgggccta gaaggccagt gaaatatgag     5940

gaggatgtga atctcggctc tggcacgcgg gctgtggtaa gctgcgctga agctcccaac     6000

atgaagatca ttggtaaccg cattgaaagg atccgcagtg agcacgcgga aacgtggttc     6060

tttgacgaga accacccata taggacatgg gcttaccatg gaagctatga ggcccccaca     6120

caagggtcag cgtcctctct aataaacggg gttgtcaggc tcctgtcaaa accctgggat     6180

gtggtgactg gagtcacagg aatagccatg accgacacca caccgtatgg tcagcaaaga     6240

gttttcaagg aaaaagtgga cactagggtg ccagaccccc aagaaggcac tcgtcaggtt     6300

atgagcatgg tctcttcctg gttgtggaaa gagctaggca aacacaaacg gccacgagtc     6360

tgtaccaaag aagagttcat caacaaggtt cgtagcaatg cagcattagg ggcaatattt     6420

gaagaggaaa aagagtggaa gactgcagtg gaagctgtga acgatccaag gttctgggct     6480

ctagtggaca aggaaagaga gcaccacctg agaggagagt gccagagttg tgtgtataac     6540

atgatgggaa aaagagaaaa gaaacaaggg gaatttggaa aggccaaggg cagccgcgcc     6600

atctggtata tgtggctagg ggctagattt ctagagttcg aagcccttgg attcttgaac     6660

gaggatcact ggatggggag agagaactca ggaggtggtg ttgaagggct gggattacaa     6720

agactcggat atgtcctaga agagatgagt cgtataccag gaggaaggat gtatgcagat     6780

gacactgctg gctgggacac ccgcattagc aggtttgatc tggagaatga agctctaatc     6840

accaaccaaa tggagaaagg gcacagggcc ttggcattgg ccataatcaa gtacacatac     6900

caaaacaaag tggtaaaggt ccttagacca gctgaaaaag ggaaaacagt tatggacatt     6960

atttcgagac aagaccaaag ggggagcgga caagttgtca cttacgctct taacacattt     7020

accaacctag tggtgcaact cattcggaat atggaggctg aggaagttct agagatgcaa     7080

gacttgtggc tgctgcggag gtcagagaaa gtgaccaact ggttgcagag caacggatgg     7140

gataggctca aacgaatggc agtcagtgga gatgattgcg ttgtgaagcc aattgatgat     7200

aggtttgcac atgccctcag gttcttgaat gatatgggaa aagttagaaa ggacacacaa     7260

gagtggaaac cctcaactgg atgggacaac tgggaagaag ttccgttttg ctcccaccac     7320

ttcaacaagc tccatctcaa ggacgggagg tccattgtgg ttccctgccg ccaccaagat     7380

gaactgattg gccgggcccg cgtctctcca ggggcgggat ggagcatccg ggagactgct     7440

tgcctagcaa aatcatatgc gcagatgtgg cagctccttt atttccacag aagggacctc     7500

cgactgatgg ccaatgccat ttgttcatct gtgccagttg actgggttcc aactgggaga     7560

actacctggt caatccatgg aaagggagaa tggatgacca ctgaagacat gcttgtggtg     7620

tggaacagag tgtggattga ggagaacgac cacatggaag acaagacccc agttacgaaa     7680

tggacagaca ttccctattt gggaaaaagg gaagacttgt ggtgtggatc tctcataggg     7740

cacagaccgc gcaccacctg ggctgagaac attaaaaaca cagtcaacat ggtgcgcagg     7800

atcataggtg atgaagaaaa gtacatggac tacctatcca cccaagttcg ctacttgggt     7860

gaagaagggt ctacacctgg agtgctgtaa                                      7890


<210>  6
<211>  7890
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Vaccine candidate ZIKV-DO-scattered entire nonstructural region

<400>  6
gatgtagggt gctcggtaga cttctcaaag aaggaaacga gatgcggtac gggggtattc       60

gtctataacg atgttgaagc ctggcgtgac aggtacaaat accatcctga ttccccccgt      120

cgattggcag cagcggtcaa gcaagcgtgg gaagatggta tatgcgggat ctcgtctgtt      180

tcacgtatgg aaaacataat gtggagatcg gtagaagggg agctaaacgc aatcctagaa      240

gagaatggtg ttcaactgac ggtagttgta ggatctgtaa aaaacccgat gtggagaggt      300

ccgcagagat tgccggtacc tgtaaacgag ctgccccacg gttggaaggc ttggggtaaa      360

tcgtacttcg taagagcagc aaaaacaaat aactcgtttg tcgtggatgg tgatacactg      420

aaggaatgtc cactcaaaca tcgtgcatgg aactcgtttc ttgtagagga tcatggtttc      480

ggggtatttc atactagtgt ctggctaaag gttagagaag attattcgtt agagtgtgat      540

ccggccgtta ttggtacagc tgttaaagga aaggaggcgg tacacagtga tctaggttac      600

tggattgaaa gtgagaagaa tgatacatgg aggctaaaga gggcccatct aatcgagatg      660

aaaacgtgtg aatggccgaa gtcccacacg ttgtggacag atggtataga agagtcggat      720

ctgatcatac cgaagtcttt agcggggcca ctcagtcatc acaatacgag agagggctat      780

aggacccaaa tgaaaggtcc atggcactcg gaagagcttg aaatacggtt tgaggaatgt      840

ccaggcacta aagtccacgt ggaagaaaca tgtggtacaa gaggaccgtc tctgagatcg      900

accactgcaa gtggaagggt aatcgaggaa tggtgttgca gggagtgcac gatgccccca      960

ctatcgttcc gggcgaaaga tggctgttgg tatggtatgg agatacgtcc caggaaagaa     1020

ccggaaagca acttagtacg ttcaatggta actgcaggat cgactgatca catggatcac     1080

ttctcccttg gagtacttgt aatcctgctc atggtacagg aagggctaaa gaagagaatg     1140

acgacaaaga tcataataag cacatcgatg gcagtactgg tagctatgat actgggagga     1200

ttttcgatga gtgacctagc taagcttgcg attttgatgg gtgcgacctt cgcggaaatg     1260

aatactggag gagatgtagc gcatctggcg ctaatagcgg catttaaagt cagaccggcg     1320

ttgctggtat cgttcatctt ccgtgctaat tggacgcccc gtgaatcgat gctgctggcg     1380

ttggcctcgt gtctattgca aactgcgata tccgccttgg aaggtgacct gatggtactc     1440

atcaatggtt ttgcgttggc ctggttagca atacgagcga tggtagttcc acgcacggat     1500

aacatcacgt tggcaatcct agctgctctg acgccactgg cccgtggcac actgcttgta     1560

gcgtggagag cgggccttgc tacgtgcggg gggtttatgc tactctctct gaaaggaaaa     1620

ggcagtgtaa agaagaactt accgtttgtc atggcgctgg gactaacggc tgtaaggctg     1680

gtcgatccca tcaacgtagt aggactgctg ttactaacaa ggagtgggaa acggagctgg     1740

ccgcctagcg aagtactaac agctgttggt ctgatatgcg cattggcggg agggttcgcg     1800

aaggcagata tagaaatggc tgggccgatg gccgcggtag gtctgctaat agtcagttac     1860

gtagtctcag gaaaaagtgt ggacatgtat attgaaagag cgggtgacat cacatgggaa     1920

aaagatgcgg aagtaactgg aaacagtccg cggctcgatg tagcgctaga tgaaagtggt     1980

gatttttccc tggtagagga tgacggtccc cccatgagag aaatcatact caaagtagtc     2040

ctgatgacga tctgtggcat gaatccgata gccataccgt ttgcagctgg tgcgtggtac     2100

gtatacgtaa agactggaaa acgtagtggt gctctatggg atgtacctgc tcccaaagaa     2160

gtaaaaaaag gggagaccac ggatggagta tacagagtaa tgacgcgtag actgctaggt     2220

tcgacacaag ttggtgtagg agttatgcaa gaaggggtct ttcatactat gtggcatgtc     2280

acaaaaggtt ccgcgctgcg tagcggtgaa ggtagacttg atccgtactg gggagatgta     2340

aagcaggatc tagtatcata ctgtggtccg tggaagctag atgcggcctg ggacggtcac     2400

agcgaggtac agctcttggc ggtacccccc ggagaaagag cgaggaatat ccagactcta     2460

cccggaatat ttaaaacaaa ggatggtgac attggagcgg tagcgctgga ttatccagca     2520

ggaacgtcag gatctccgat cctagacaaa tgtgggagag taataggact ttatggtaat     2580

ggggtcgtaa tcaaaaatgg tagttatgtt agtgcgatca cccaaggtag gagggaagaa     2640

gaaactcctg ttgaatgctt cgagccgtcg atgctgaaaa agaagcagct aacggtctta     2700

gacttacatc ctggagcggg gaaaacccga agagttcttc cggaaatagt ccgtgaagcg     2760

ataaaaacac gtctccgtac tgtaatctta gctccgacca gggttgtagc tgctgaaatg     2820

gaagaggccc ttcgtgggct tccagtacgt tatatgacga cagcagtcaa tgtaacccac     2880

tctggtacag aaatcgttga cttaatgtgt catgccacct ttacttcacg tctactacaa     2940

ccaatcagag ttcccaacta taatctatat attatggatg aagcccactt cacggatccc     3000

tcaagtatag cggcaagagg atatatttca acaagggttg aaatgggcga ggcggcggcc     3060

atcttcatga cggccacgcc accgggaacc cgtgatgcat ttccggattc caactcaccg     3120

attatggaca cggaagtgga agttccagag agagcgtgga gctcaggttt tgattgggta     3180

acggatcatt cgggaaaaac agtttggttt gttccgagcg tgaggaatgg caatgagata     3240

gcagcttgtc taacaaaggc tggtaaacgg gtcatacaac tcagcagaaa aacttttgaa     3300

acagagttcc aaaaaacaaa acatcaagaa tgggactttg ttgttacaac tgacatatca     3360

gagatgggtg ccaactttaa agctgaccgt gtcatagatt cgaggagatg cctaaagccg     3420

gtcatactag atggcgagcg agtcattctg gcgggaccca tgccggtcac acatgcgagc     3480

gctgcccaaa ggagggggcg tataggcagg aatccgaaca aacctggtga tgagtatcta     3540

tatggaggtg gttgcgcaga gacggacgaa gaccatgcgc actggcttga agcgagaatg     3600

ctcctagaca atatttatct ccaagatggt ctcatagcct cgctatatcg acctgaagcc     3660

gacaaagtag cggccattga gggtgagttc aagctaagga cggagcaacg taagaccttt     3720

gtagaactca tgaaaagagg tgatcttcct gtatggctgg cctatcaagt tgcatctgcg     3780

ggaataacct atacagatag aagatggtgt tttgatggca cgacgaacaa caccataatg     3840

gaagattcgg tgccggcaga agtgtggacc agacatggag agaaacgtgt gctcaaaccg     3900

aggtggatgg atgccagagt ttgttcagat catgcggcgc tgaagtcatt taaggagttt     3960

gcggctggga aaagaggtgc ggcttttggt gtaatggaag ccctgggaac actgccggga     4020

cacatgacgg agagattcca agaagccatt gataacctcg ctgtactcat gcgggcggag     4080

actggaagta ggccttacaa agccgcggcg gcgcaattgc cggaaaccct agagacgata     4140

atgcttttag ggttgctggg tacagtctcg ctaggaatct tctttgtctt gatgcgtaac     4200

aagggcatag gtaagatggg ctttggtatg gtgactctag gggccagcgc gtggctcatg     4260

tggctatcgg aaattgaacc agccagaata gcatgtgtcc taattgttgt attcctattg     4320

ctggtagtac tcatacctga accagaaaag caacgttctc cccaggataa ccaaatggca     4380

ataatcatca tggtagcggt aggtcttcta ggcttgatta cggccaatga actaggatgg     4440

ttggaaagaa caaagtcgga cctaagccat ctaatgggta ggagagagga aggggcaacc     4500

ataggtttct caatggatat tgacctgcgt ccagcctcag cgtgggccat ctatgcggcc     4560

ttgacaacgt tcattacccc ggccgtccaa catgcggtga ccacctcgta caacaactat     4620

tccttaatgg cgatggcgac gcaagctggt gtgttgtttg gtatgggtaa agggatgccg     4680

ttctacgcat gggattttgg agtcccgcta ctaatgatag gttgttactc acaattaacg     4740

cccctgaccc taatagtagc catcatttta ctcgtggcgc attacatgta cttaatccca     4800

gggctacagg cagcagcggc gcgtgctgcg cagaagagaa cggcggctgg catcatgaaa     4860

aaccctgttg tagatggaat agtagtgact gacatagaca caatgacgat tgacccccaa     4920

gtagagaaaa agatgggtca ggtgctacta atagcagtag cggtctccag cgcgatactg     4980

tcgcggaccg cctggggttg gggggaggcg ggggccctga taacagccgc aacgtccact     5040

ttgtgggaag gttctccgaa caaatactgg aactcgtcta cagccacgtc actgtgtaat     5100

atttttaggg gtagttactt ggcgggagct tctctaatat acacagtaac gagaaacgct     5160

ggtttggtca agcgtcgtgg gggtggtaca ggagagacgc tgggagagaa atggaaagcc     5220

cgcttgaatc agatgtcggc gctggagttc tattcctaca aaaaatcagg catcacggag     5280

gtgtgccgtg aagaggcccg tcgcgccctc aaagacggtg tggcgacggg aggccatgcg     5340

gtgtcccgag gtagtgcaaa gctaagatgg ttggtagagc ggggatatct gcagccctat     5400

ggtaaggtca ttgatctagg atgtggccgt gggggctggt cgtactacgc cgcgaccatc     5460

cgcaaagtac aagaagtgaa aggttacaca aaaggtggcc ctggtcatga agaacccgtg     5520

ttggtgcaaa gttatgggtg gaatatagtc cgtctaaaga gtggggtaga cgtctttcat     5580

atggcggcgg agccgtgtga tacgctgctg tgtgatatag gtgagtcgtc atctagtccg     5640

gaagtggaag aagcgcggac gctccgtgtc ctctccatgg taggggattg gctagaaaaa     5700

agaccgggag ccttttgtat aaaagtattg tgcccatata ccagcactat gatggaaacg     5760

ctggagcgac tacagcgtag gtatggtgga ggactggtaa gagtgccact atcccgcaac     5820

tcgacacatg agatgtattg ggtctctggt gcgaaaagca ataccataaa aagtgtatcc     5880

accacgtcgc agctcctctt agggcgcatg gatgggccta gacgtccagt gaaatatgaa     5940

gaggatgtga atctaggctc tggcacgcgt gctgtggtaa gttgcgctga agcgcccaac     6000

atgaaaatca ttggtaatcg cattgaaagg atacgcagtg agcatgcgga aacgtggttt     6060

tttgacgaga atcacccata taggacgtgg gcttaccatg gtagctatga ggcgcccaca     6120

caaggttcag cgtcctcgct aataaacggt gttgtcaggc tactgtcaaa accgtgggat     6180

gtggtaactg gagtcacggg aatagccatg acggacacca caccgtatgg tcaacaaaga     6240

gtttttaagg aaaaagtaga cactagggta ccagaccccc aagaaggtac tcgtcaggta     6300

atgagcatgg tatcttcctg gttatggaaa gagctaggta aacacaaacg tccacgagtc     6360

tgtacgaaag aagagtttat caacaaggta cgtagcaatg cggcattagg ggcgatattt     6420

gaagaagaaa aagagtggaa aactgcagtg gaagcggtga acgatccgag gttctgggcg     6480

ctagtggaca aagaaagaga gcatcacctg agaggtgagt gccagtcgtg tgtgtataat     6540

atgatgggaa aacgtgaaaa gaaacaaggt gaatttggaa aagccaaggg cagccgtgcc     6600

atctggtata tgtggctagg tgctagattt ctagaattcg aagcccttgg attcttgaat     6660

gaggatcact ggatgggtag agagaactcg ggaggtggtg tagaagggct gggtttacaa     6720

agactaggat atgtcctaga agaaatgagt cgtataccgg gaggaaggat gtatgcggat     6780

gacactgcgg gctgggacac gcgcattagc cgttttgatc tggaaaatga agctctaata     6840

accaaccaaa tggaaaaagg gcacagggcg ttggcattgg cgataatcaa gtatacatac     6900

caaaataaag tggtaaaagt ccttagaccg gctgaaaaag gtaaaacagt tatggatatt     6960

atttcgcgtc aagaccaaag gggtagcgga caagtagtca cttacgcgct taacacattt     7020

acgaacctag tggtacaact cattcgtaat atggaggcgg aggaagttct agaaatgcaa     7080

gacttatggc tgctgcgtag gtcagagaaa gtaaccaact ggttacagag caacggttgg     7140

gataggctaa aacgaatggc ggtcagtgga gatgattgtg ttgtgaagcc gattgatgat     7200

cgttttgcac atgcgctcag gttcttaaat gatatgggta aagttagaaa agacacacaa     7260

gaatggaaac cctcgactgg atgggataac tgggaagaag taccgttttg ctcgcaccac     7320

ttcaataagc tccatctaaa ggacgggcgt tccattgtgg taccctgccg ccatcaagat     7380

gaactaattg gccgggcgcg cgtctctccg ggggcgggat ggtcgatccg ggagacggct     7440

tgcctagcga aatcatatgc gcaaatgtgg cagctacttt atttccatag aagggaccta     7500

cgactgatgg cgaatgccat ttgttcgtct gtgccagtag actgggttcc gactgggaga     7560

acgacctggt caatacatgg aaagggtgaa tggatgacga ctgaagacat gctagtggtg     7620

tggaatagag tgtggataga ggagaacgat cacatggaag ataagacccc agtaacgaaa     7680

tggacggaca ttccctattt aggaaaaagg gaagatttgt ggtgtggttc tctcataggt     7740

cacagaccgc gtaccacctg ggcggagaac attaaaaata cagtcaacat ggtacgcagg     7800

atcataggtg atgaagaaaa atatatggac tacctatcga cccaagttcg ttacttgggt     7860

gaagaaggtt ctacacctgg tgtgctgtaa                                      7890


<210>  7
<211>  7890
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Vaccine candidate ZIKV-DO-scattered sequence with deoptimized 
       region, NS1 to NS5

<400>  7
gatgtagggt gctcggtaga cttctcaaag aaggaaacga gatgcggtac gggggtattc       60

gtctataacg atgttgaagc ctggcgtgac aggtacaaat accatcctga ttccccccgt      120

cgattggcag cagcggtcaa gcaagcgtgg gaagatggta tatgcgggat ctcgtctgtt      180

tcacgtatgg aaaacataat gtggagatcg gtagaagggg agctaaacgc aatcctagaa      240

gagaatggtg ttcaactgac ggtagttgta ggatctgtaa aaaacccgat gtggagaggt      300

ccgcagagat tgccggtacc tgtaaacgag ctgccccacg gttggaaggc ttggggtaaa      360

tcgtacttcg taagagcagc aaaaacaaat aactcgtttg tcgtggatgg tgatacactg      420

aaggaatgtc cactcaaaca tcgtgcatgg aactcgtttc ttgtagagga tcatggtttc      480

ggggtatttc atactagtgt ctggctaaag gttagagaag attattcgtt agagtgtgat      540

ccggccgtta ttggtacagc tgttaaagga aaggaggcgg tacacagtga tctaggttac      600

tggattgaaa gtgagaagaa tgatacatgg aggctaaaga gggcccatct aatcgagatg      660

aaaacgtgtg aatggccgaa gtcccacacg ttgtggacag atggtataga agagtcggat      720

ctgatcatac cgaagtcttt agcggggcca ctcagtcatc acaatacgag agagggctat      780

aggacccaaa tgaaaggtcc atggcactcg gaagagcttg aaatacggtt tgaggaatgt      840

ccaggcacta aagtccacgt ggaagaaaca tgtggtacaa gaggaccgtc tctgagatcg      900

accactgcaa gtggaagggt aatcgaggaa tggtgttgca gggagtgcac gatgccccca      960

ctatcgttcc gggcgaaaga tggctgttgg tatggtatgg agatacgtcc caggaaagaa     1020

ccggaaagca acttagtacg ttcaatggta actgcaggat cgactgatca catggatcac     1080

ttctcccttg gagtacttgt aatcctgctc atggtacagg aagggctaaa gaagagaatg     1140

acgacaaaga tcataataag cacatcgatg gcagtactgg tagctatgat actgggagga     1200

ttttcgatga gtgacctagc taagcttgcg attttgatgg gtgcgacctt cgcggaaatg     1260

aatactggag gagatgtagc gcatctggcg ctaatagcgg catttaaagt cagaccggcg     1320

ttgctggtat cgttcatctt ccgtgctaat tggacgcccc gtgaatcgat gctgctggcg     1380

ttggcctcgt gtctattgca aactgcgata tccgccttgg aaggtgacct gatggtactc     1440

atcaatggtt ttgcgttggc ctggttagca atacgagcga tggtagttcc acgcacggat     1500

aacatcacgt tggcaatcct agctgctctg acgccactgg cccgtggcac actgcttgta     1560

gcgtggagag cgggccttgc tacgtgcggg gggtttatgc tactctctct gaaaggaaaa     1620

ggcagtgtaa agaagaactt accgtttgtc atggcgctgg gactaacggc tgtaaggctg     1680

gtcgatccca tcaacgtagt aggactgctg ttactaacaa ggagtgggaa acggagctgg     1740

ccgcctagcg aagtactaac agctgttggt ctgatatgcg cattggcggg agggttcgcg     1800

aaggcagata tagaaatggc tgggccgatg gccgcggtag gtctgctaat agtcagttac     1860

gtagtctcag gaaaaagtgt ggacatgtat attgaaagag cgggtgacat cacatgggaa     1920

aaagatgcgg aagtaactgg aaacagtccg cggctcgatg tagcgctaga tgaaagtggt     1980

gatttttccc tggtagagga tgacggtccc cccatgagag aaatcatact caaagtagtc     2040

ctgatgacga tctgtggcat gaatccgata gccataccgt ttgcagctgg tgcgtggtac     2100

gtatacgtaa agactggaaa acgtagtggt gctctatggg atgtacctgc tcccaaagaa     2160

gtaaaaaaag gggagaccac ggatggagta tacagagtaa tgacgcgtag actgctaggt     2220

tcgacacaag ttggtgtagg agttatgcaa gaaggggtct ttcatactat gtggcatgtc     2280

acaaaaggtt ccgcgctgcg tagcggtgaa ggtagacttg atccgtactg gggagatgta     2340

aagcaggatc tagtatcata ctgtggtccg tggaagctag atgcggcctg ggacggtcac     2400

agcgaggtac agctcttggc ggtacccccc ggagaaagag cgaggaatat ccagactcta     2460

cccggaatat ttaaaacaaa ggatggtgac attggagcgg tagcgctgga ttatccagca     2520

ggaacgtcag gatctccgat cctagacaaa tgtgggagag taataggact ttatggtaat     2580

ggggtcgtaa tcaaaaatgg tagttatgtt agtgcgatca cccaaggtag gagggaagaa     2640

gaaactcctg ttgaatgctt cgagccgtcg atgctgaaaa agaagcagct aacggtctta     2700

gacttacatc ctggagcggg gaaaacccga agagttcttc cggaaatagt ccgtgaagcg     2760

ataaaaacac gtctccgtac tgtaatctta gctccgacca gggttgtagc tgctgaaatg     2820

gaagaggccc ttcgtgggct tccagtacgt tatatgacga cagcagtcaa tgtaacccac     2880

tctggtacag aaatcgttga cttaatgtgt catgccacct ttacttcacg tctactacaa     2940

ccaatcagag ttcccaacta taatctatat attatggatg aagcccactt cacggatccc     3000

tcaagtatag cggcaagagg atatatttca acaagggttg aaatgggcga ggcggcggcc     3060

atcttcatga cggccacgcc accgggaacc cgtgatgcat ttccggattc caactcaccg     3120

attatggaca cggaagtgga agttccagag agagcgtgga gctcaggttt tgattgggta     3180

acggatcatt cgggaaaaac agtttggttt gttccgagcg tgaggaatgg caatgagata     3240

gcagcttgtc taacaaaggc tggtaaacgg gtcatacaac tcagcagaaa aacttttgaa     3300

acagagttcc aaaaaacaaa acatcaagaa tgggactttg ttgttacaac tgacatatca     3360

gagatgggtg ccaactttaa agctgaccgt gtcatagatt cgaggagatg cctaaagccg     3420

gtcatactag atggcgagcg agtcattctg gcgggaccca tgccggtcac acatgcgagc     3480

gctgcccaaa ggagggggcg tataggcagg aatccgaaca aacctggtga tgagtatcta     3540

tatggaggtg gttgcgcaga gacggacgaa gaccatgcgc actggcttga agcgagaatg     3600

ctcctagaca atatttatct ccaagatggt ctcatagcct cgctatatcg acctgaagcc     3660

gacaaagtag cggccattga gggtgagttc aagctaagga cggagcaacg taagaccttt     3720

gtagaactca tgaaaagagg tgatcttcct gtatggctgg cctatcaagt tgcatctgcg     3780

ggaataacct atacagatag aagatggtgt tttgatggca cgacgaacaa caccataatg     3840

gaagattcgg tgccggcaga agtgtggacc agacatggag agaaacgtgt gctcaaaccg     3900

aggtggatgg atgccagagt ttgttcagat catgcggcgc tgaagtcatt taaggagttt     3960

gcggctggga aaagaggtgc ggcttttggt gtaatggaag ccctgggaac actgccggga     4020

cacatgacgg agagattcca agaagccatt gataacctcg ctgtactcat gcgggcggag     4080

actggaagta ggccttacaa agccgcggcg gcgcaattgc cggaaaccct agagacgata     4140

atgcttttag ggttgctggg tacagtctcg ctaggaatct tctttgtctt gatgcgtaac     4200

aagggcatag gtaagatggg ctttggtatg gtgactctag gggccagcgc gtggctcatg     4260

tggctatcgg aaattgaacc agccagaata gcatgtgtcc taattgttgt attcctattg     4320

ctggtagtac tcatacctga accagaaaag caacgttctc cccaggataa ccaaatggca     4380

ataatcatca tggtagcggt aggtcttcta ggcttgatta cggccaatga actaggatgg     4440

ttggaaagaa caaagtcgga cctaagccat ctaatgggta ggagagagga aggggcaacc     4500

ataggtttct caatggatat tgacctgcgt ccagcctcag cgtgggccat ctatgcggcc     4560

ttgacaacgt tcattacccc ggccgtccaa catgcggtga ccacctcgta caacaactat     4620

tccttaatgg cgatggcgac gcaagctggt gtgttgtttg gtatgggtaa agggatgccg     4680

ttctacgcat gggattttgg agtcccgcta ctaatgatag gttgttactc acaattaacg     4740

cccctgaccc taatagtagc catcatttta ctcgtggcgc attacatgta cttaatccca     4800

gggctacagg cagcagcggc gcgtgctgcg cagaagagaa cggcggctgg catcatgaaa     4860

aaccctgttg tagatggaat agtagtgact gacatagaca caatgacgat tgacccccaa     4920

gtagagaaaa agatgggtca ggtgctacta atagcagtag cggtctccag cgcgatactg     4980

tcgcggaccg cctggggttg gggggaggcg ggggccctga taacagccgc aacgtccact     5040

ttgtgggaag gttctccgaa caaatactgg aactcgtcta cagccacgtc actgtgtaat     5100

atttttaggg gtagttactt ggcgggagct tctctaatat acacagtaac gagaaacgct     5160

ggtttggtca agcgtcgtgg gggtggtaca ggagagacgc tgggagagaa atggaaagcc     5220

cgcttgaatc agatgtcggc gctggagttc tattcctaca aaaaatcagg catcacggag     5280

gtgtgccgtg aagaggcccg tcgcgccctc aaagacggtg tggcgacggg aggccatgcg     5340

gtgtcccgag gtagtgcaaa gctaagatgg ttggtagagc ggggatatct gcagccctat     5400

ggtaaggtca ttgatctagg atgtggccgt gggggctggt cgtactacgc cgcgaccatc     5460

cgcaaagtac aagaagtgaa aggttacaca aaaggtggcc ctggtcatga agaacccgtg     5520

ttggtgcaaa gttatgggtg gaatatagtc cgtctaaaga gtggggtaga cgtctttcat     5580

atggcggcgg agccgtgtga tacgctgctg tgtgatatag gtgagtcgtc atctagtccg     5640

gaagtggaag aagcgcggac gctccgtgtc ctctccatgg taggggattg gctagaaaaa     5700

agaccgggag ccttttgtat aaaagtattg tgcccatata ccagcactat gatggaaacg     5760

ctggagcgac tacagcgtag gtatggtgga ggactggtaa gagtgccact atcccgcaac     5820

tcgacacatg agatgtattg ggtctctggt gcgaaaagca ataccataaa aagtgtatcc     5880

accacgtcgc agctcctctt agggcgcatg gatgggccta gacgtccagt gaaatatgaa     5940

gaggatgtga atctaggctc tggcacgcgt gctgtggtaa gttgcgctga agcgcccaac     6000

atgaaaatca ttggtaatcg cattgaaagg atacgcagtg agcatgcgga aacgtggttt     6060

tttgacgaga atcacccata taggacgtgg gcttaccatg gtagctatga ggcgcccaca     6120

caaggttcag cgtcctcgct aataaacggt gttgtcaggc tactgtcaaa accgtgggat     6180

gtggtaactg gagtcacggg aatagccatg acggacacca caccgtatgg tcaacaaaga     6240

gtttttaagg aaaaagtaga cactagggta ccagaccccc aagaaggtac tcgtcaggta     6300

atgagcatgg tatcttcctg gttatggaaa gagctaggta aacacaaacg tccacgagtc     6360

tgtacgaaag aagagtttat caacaaggta cgtagcaatg cggcattagg ggcgatattt     6420

gaagaagaaa aagagtggaa aactgcagtg gaagcggtga acgatccgag gttctgggcg     6480

ctagtggaca aagaaagaga gcatcacctg agaggtgagt gccagtcgtg tgtgtataat     6540

atgatgggaa aacgtgaaaa gaaacaaggt gaatttggaa aagccaaggg cagccgtgcc     6600

atctggtata tgtggctagg tgctagattt ctagaattcg aagcccttgg attcttgaat     6660

gaggatcact ggatgggtag agagaactcg ggaggtggtg tagaagggct gggtttacaa     6720

agactaggat atgtcctaga agaaatgagt cgtataccgg gaggaaggat gtatgcggat     6780

gacactgcgg gctgggacac gcgcattagc cgttttgatc tggaaaatga agctctaata     6840

accaaccaaa tggaaaaagg gcacagggcg ttggcattgg cgataatcaa gtatacatac     6900

caaaataaag tggtaaaagt ccttagaccg gctgaaaaag gtaaaacagt tatggatatt     6960

atttcgcgtc aagaccaaag gggtagcgga caagtagtca cttacgcgct taacacattt     7020

acgaacctag tggtacaact cattcgtaat atggaggcgg aggaagttct agaaatgcaa     7080

gacttatggc tgctgcgtag gtcagagaaa gtaaccaact ggttacagag caacggttgg     7140

gataggctaa aacgaatggc ggtcagtgga gatgattgtg ttgtgaagcc gattgatgat     7200

cgttttgcac atgcgctcag gttcttaaat gatatgggta aagttagaaa agacacacaa     7260

gaatggaaac cctcgactgg atgggataac tgggaagaag taccgttttg ctcgcaccac     7320

ttcaataagc tccatctaaa ggacgggcgt tccattgtgg taccctgccg ccatcaagat     7380

gaactaattg gccgggcgcg cgtctctccg ggggcgggat ggtcgatccg ggagacggct     7440

tgcctagcga aatcatatgc gcaaatgtgg cagctacttt atttccatag aagggaccta     7500

cgactgatgg cgaatgccat ttgttcgtct gtgccagtag actgggttcc gactgggaga     7560

acgacctggt caatacatgg aaagggtgaa tggatgacga ctgaagacat gctagtggtg     7620

tggaatagag tgtggataga ggagaacgat cacatggaag ataagacccc agtaacgaaa     7680

tggacggaca ttccctattt aggaaaaagg gaagatttgt ggtgtggttc tctcataggt     7740

cacagaccgc gtaccacctg ggcggagaac attaaaaata cagtcaacat ggtacgcagg     7800

atcataggtg atgaagaaaa atatatggac tacctatcga cccaagttcg ttacttgggt     7860

gaagaaggtt ctacacctgg tgtgctgtaa                                      7890


<210>  8
<211>  3854
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Vaccine candidate ZIKV-DO nonstructural region nucleotide 
       sequence, regions NS1 to NS3

<400>  8
gtcggttgtt cggtagattt ttcgaaaaaa gaaacgcgat gtggtacggg tgtatttgta       60

tataatgacg tagaagcgtg gcgagaccga tacaagtatc atccggactc gccgcgacga      120

ttagcggcgg cggtaaaaca agcgtgggaa gacggtatat gcggtatatc gtcggtatcg      180

cgaatggaaa atataatgtg gcgatcggta gaaggtgagt taaatgcgat actagaagag      240

aatggcgtac aactaacggt agtagtcggc tcggtaaaaa atcccatgtg gcgaggtccg      300

cagcgattgc ccgtccccgt caatgagcta ccccatggtt ggaaggcgtg gggtaaatcg      360

tacttcgtac gagcggcgaa gacgaataat tcctttgtag tcgatggtga cacgctaaag      420

gaatgcccgt taaaacatcg agcgtggaat tcctttttgg tcgaggatca tggtttcggt      480

gtattccata ccagtgtatg gttaaaggta cgagaagatt attcgttaga gtgtgatccg      540

gccgtaattg gcacggcggt aaagggcaag gaggcggtac atagtgatct cggttactgg      600

attgagagtg agaagaatga cacgtggcgc ctaaagcgcg cccatctaat agagatgaaa      660

acgtgtgaat ggccgaagtc gcacacgttg tggacggatg gcatagaaga gagtgatcta      720

ataataccca agtcgttagc gggtccgtta tcccatcata atacccgaga gggttaccgc      780

acccaaatga aaggtccgtg gcatagtgaa gagttggaaa ttcggttcga ggaatgcccg      840

ggtaccaagg tacacgtcga ggaaacgtgt ggcacgcgag gcccgtcgct acgatcgacc      900

accgcgtccg gccgcgtcat agaggaatgg tgctgccgcg agtgcacgat gcccccgcta      960

tcgttccggg cgaaagatgg ttgttggtat ggaatggaga tacgcccccg caaagaaccg     1020

gaatccaatt tagtacgctc gatggtcacc gcgggctcga ccgatcatat ggaccatttc     1080

tcgttgggcg tcttggtcat actattaatg gtccaagaag gtctaaagaa gcgaatgacc     1140

acgaagataa taatatccac gtcgatggcg gtcctagtag cgatgatact aggcggcttt     1200

tcgatgagtg acctagcgaa gttggcgatt ttgatgggtg ccaccttcgc ggaaatgaat     1260

accggcggcg atgtagcgca tctagcgcta atagcggcgt tcaaagtacg accggcgttg     1320

ctagtatcgt tcatattccg agcgaattgg acgccccgtg aatccatgct actagccttg     1380

gcctcgtgtt tgttgcaaac cgcgatatcg gccttggaag gtgacctaat ggtattaata     1440

aatggtttcg cgttggcctg gttggcgata cgagcgatgg tagtaccgcg caccgataat     1500

ataaccttgg cgatactagc ggcgctaacg ccgctagccc ggggtacgct attggtcgcg     1560

tggcgagcgg gtttggcgac ctgcggtggt tttatgttat tatcgctaaa gggcaaaggt     1620

agtgtcaaga agaatttacc gtttgtaatg gccctaggcc tcaccgcggt ccgcctagta     1680

gaccccataa atgtcgtcgg cctactatta ttaacgcgca gtggtaagcg gtcctggccc     1740

ccctccgaag tattaacggc ggtaggtcta atatgcgcgt tggcgggcgg tttcgccaag     1800

gcggatatag agatggcggg tcccatggcc gcggtaggtc tactcattgt aagttacgtc     1860

gtatcgggca agagtgtcga catgtacatt gaacgagcgg gtgacataac gtgggaaaaa     1920

gatgcggaag taaccggcaa tagtccccgg ttagatgtcg cgctcgatga gagtggtgat     1980

ttctcgctag tcgaggatga cggtcccccg atgcgagaga taatattaaa ggtcgtacta     2040

atgaccatat gtggtatgaa tccgatagcc atacccttcg cggcgggcgc gtggtacgta     2100

tacgtcaaga ccggcaaacg cagtggtgcg ctctgggatg tccccgcgcc caaggaagta     2160

aaaaagggtg agaccacgga tggcgtctac cgagtaatga cccgtcgact actcggttcg     2220

acgcaagtag gcgtcggcgt aatgcaagag ggtgtattcc acaccatgtg gcatgtaacg     2280

aaaggctcgg cgctacgatc cggtgaaggt cgattggatc cgtactgggg cgatgtaaag     2340

caagatctag tctcgtactg tggtccgtgg aagctcgatg ccgcctggga cggtcactcc     2400

gaggtccagt tattggccgt ccccccgggc gagcgagcgc gcaatataca aactctaccc     2460

ggcatattca agacgaagga tggtgacatt ggcgcggtag cgctagatta cccggcgggc     2520

acttcgggct cgccgatact cgacaagtgt ggtcgagtca taggcttgta tggtaatggt     2580

gtagtcataa aaaatggtag ttatgtaagt gccataaccc aaggtcgccg cgaagaagag     2640

acccccgtag agtgcttcga gccctcgatg ctaaagaaga agcaactcac tgtattagac     2700

ttgcatcccg gcgcgggtaa aacccgccga gtattgcccg aaatagtacg tgaagccata     2760

aaaacgcgat tacgtaccgt catattagcg ccgacccgcg tagtagcggc ggaaatggag     2820

gaggccttgc gaggtttgcc ggtccgttat atgacgacgg cggtaaatgt aacccattcg     2880

ggcacggaaa tagtagactt aatgtgccat gccaccttca cctcgcgtct cctccagccg     2940

atacgagtac ccaattataa tctatatatt atggatgagg cccatttcac ggatccctcg     3000

agtatagcgg cgcgaggcta catttcgacg cgcgtagaga tgggtgaggc ggcggccata     3060

ttcatgaccg ccacgccgcc gggcacccgt gacgcgttcc cggactcgaa ttcgccgatt     3120

atggacaccg aagtcgaagt accggagcga gcctggtcct cgggttttga ttgggtcacg     3180

gatcattcgg gcaaaacggt atggttcgta ccgtccgtcc gcaatggtaa tgagatagcg     3240

gcgtgtctaa cgaaggcggg caaacgggta atacagttat cccgaaagac cttcgagacg     3300

gagttccaaa aaacgaaaca tcaagagtgg gacttcgtag tcacgaccga catttcggag     3360

atgggtgcca atttcaaagc ggaccgtgta atagattcgc gccgatgcct caagccggta     3420

atattggatg gtgagcgagt aattctagcg ggccccatgc ccgtaacgca tgcctccgcg     3480

gcccaacgcc gcggtcgcat aggtcgcaat cccaataaac ccggcgatga gtatctatat     3540

ggcggtggtt gcgcggagac cgacgaagac catgcgcatt ggttggaagc gcgaatgtta     3600

ttggacaata tttacttaca agatggttta atagcctcgt tatatcgacc cgaggccgac     3660

aaagtagcgg ccattgaggg cgagttcaag ttgcgcacgg agcaacgcaa gaccttcgtc     3720

gaattaatga aacgaggcga tttgcccgta tggctagcct atcaagtagc gtcggccggc     3780

ataacctaca cggatcgacg atggtgcttc gatggtacga ccaataatac cataatggaa     3840

gatagtgtgc cggc                                                       3854


<210>  9
<211>  7887
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Vaccine candidate ZIKV-DO sequence, with the deoptimized 
       nonstructural regions NS1 to NS5

<400>  9
gtcggttgtt cggtagattt ttcgaaaaaa gaaacgcgat gtggtacggg tgtatttgta       60

tataatgacg tagaagcgtg gcgagaccga tacaagtatc atccggactc gccgcgacga      120

ttagcggcgg cggtaaaaca agcgtgggaa gacggtatat gcggtatatc gtcggtatcg      180

cgaatggaaa atataatgtg gcgatcggta gaaggtgagt taaatgcgat actagaagag      240

aatggcgtac aactaacggt agtagtcggc tcggtaaaaa atcccatgtg gcgaggtccg      300

cagcgattgc ccgtccccgt caatgagcta ccccatggtt ggaaggcgtg gggtaaatcg      360

tacttcgtac gagcggcgaa gacgaataat tcctttgtag tcgatggtga cacgctaaag      420

gaatgcccgt taaaacatcg agcgtggaat tcctttttgg tcgaggatca tggtttcggt      480

gtattccata ccagtgtatg gttaaaggta cgagaagatt attcgttaga gtgtgatccg      540

gccgtaattg gcacggcggt aaagggcaag gaggcggtac atagtgatct cggttactgg      600

attgagagtg agaagaatga cacgtggcgc ctaaagcgcg cccatctaat agagatgaaa      660

acgtgtgaat ggccgaagtc gcacacgttg tggacggatg gcatagaaga gagtgatcta      720

ataataccca agtcgttagc gggtccgtta tcccatcata atacccgaga gggttaccgc      780

acccaaatga aaggtccgtg gcatagtgaa gagttggaaa ttcggttcga ggaatgtccg      840

ggtaccaagg tacacgtcga ggaaacgtgt ggcacgcgag gcccgtcgct acgatcgacc      900

accgcgtccg gccgcgtcat agaggaatgg tgctgccgcg agtgcacgat gcccccgcta      960

tcgttccggg cgaaagatgg ttgttggtat ggaatggaga tacgcccccg caaagaaccg     1020

gaatccaatt tagtacgctc gatggtcacc gcgggctcga ccgatcatat ggaccatttc     1080

tcgttgggcg tcttggtcat actattaatg gtccaagaag gtctaaagaa gcgaatgacc     1140

acgaagataa taatatccac gtcgatggcg gtcctagtag cgatgatact aggcggcttt     1200

tcgatgagtg acctagcgaa gttggcgatt ttgatgggtg ccaccttcgc ggaaatgaat     1260

accggcggcg atgtagcgca tctagcgcta atagcggcgt tcaaagtacg accggcgttg     1320

ctagtatcgt tcatattccg agcgaattgg acgccccgtg aatccatgct actagccttg     1380

gcctcgtgtt tgttgcaaac cgcgatatcg gccttggaag gtgacctaat ggtattaata     1440

aatggtttcg cgttggcctg gttggcgata cgagcgatgg tagtaccgcg caccgataat     1500

ataaccttgg cgatactagc ggcgctaacg ccgctagccc ggggtacgct attggtcgcg     1560

tggcgagcgg gtttggcgac ctgcggtggt tttatgttat tatcgctaaa gggcaaaggt     1620

agtgtcaaga agaatttacc gtttgtaatg gccctaggcc tcaccgcggt ccgcctagta     1680

gaccccataa atgtcgtcgg cctactatta ttaacgcgca gtggtaagcg gtcctggccc     1740

ccctccgaag tattaacggc ggtaggtcta atatgcgcgt tggcgggcgg tttcgccaag     1800

gcggatatag agatggcggg tcccatggcc gcggtaggtc tactcattgt aagttacgtc     1860

gtatcgggca agagtgtcga catgtacatt gaacgagcgg gtgacataac gtgggaaaaa     1920

gatgcggaag taaccggcaa tagtccccgg ttagatgtcg cgctcgatga gagtggtgat     1980

ttctcgctag tcgaggatga cggtcccccg atgcgagaga taatattaaa ggtcgtacta     2040

atgaccatat gtggtatgaa tccgatagcc atacccttcg cggcgggcgc gtggtacgta     2100

tacgtcaaga ccggcaaacg cagtggtgcg ctctgggatg tccccgcgcc caaggaagta     2160

aaaaagggtg agaccacgga tggcgtctac cgagtaatga cccgtcgact actcggttcg     2220

acgcaagtag gcgtcggcgt aatgcaagag ggtgtattcc acaccatgtg gcatgtaacg     2280

aaaggctcgg cgctacgatc cggtgaaggt cgattggatc cgtactgggg cgatgtaaag     2340

caagatctag tctcgtactg tggtccgtgg aagctcgatg ccgcctggga cggtcactcc     2400

gaggtccagt tattggccgt cccgccgggc gagcgagcgc gcaatataca aactctaccc     2460

ggcatattca agacgaagga tggtgacatt ggcgcggtag cgctagatta cccggcgggc     2520

acttcgggct cgccgatact cgacaagtgt ggtcgagtca taggcttgta tggtaatggt     2580

gtagtcataa aaaatggtag ttatgtaagt gccataaccc aaggtcgccg cgaagaagag     2640

acccccgtag agtgcttcga gccctcgatg ctaaagaaga agcaactcac tgtattagac     2700

ttgcatcccg gcgcgggtaa aacccgccga gtattgcccg aaatagtacg tgaagccata     2760

aaaacgcgat tacgtaccgt catattagcg ccgacccgcg tagtagcggc ggaaatggag     2820

gaggccttgc gaggtttgcc ggtccgttat atgacgacgg cggtaaatgt aacccattcg     2880

ggcacggaaa tagtagactt aatgtgccat gccaccttca cctcgcgtct cctccagccg     2940

atacgagtac ccaattataa tctatatatt atggatgagg cccatttcac ggatccctcg     3000

agtatagcgg cgcgaggcta catttcgacg cgcgtagaga tgggtgaggc ggcggccata     3060

ttcatgaccg ccacgccgcc gggcacccgt gacgcgttcc cggactcgaa ttcgccgatt     3120

atggacaccg aagtcgaagt accggagcga gcctggtcct cgggttttga ttgggtcacg     3180

gatcattcgg gcaaaacggt atggttcgta ccgtccgtcc gcaatggtaa tgagatagcg     3240

gcgtgtctaa cgaaggcggg caaacgggta atacagttat cccgaaagac cttcgagacg     3300

gagttccaaa aaacgaaaca tcaagagtgg gacttcgtag tcacgaccga catttcggag     3360

atgggtgcca atttcaaagc ggaccgtgta atagattcgc gccgatgcct caagccggta     3420

atattggatg gtgagcgagt aattctagcg ggccccatgc ccgtaacgca tgcctccgcg     3480

gcccaacgcc gcggtcgcat aggtcgcaat cccaataaac ccggcgatga gtatctatat     3540

ggcggtggtt gcgcggagac cgacgaagac catgcgcatt ggttggaagc gcgaatgtta     3600

ttggacaata tttacttaca agatggttta atagcctcgt tatatcgacc cgaggccgac     3660

aaagtagcgg ccattgaggg cgagttcaag ttgcgcacgg agcaacgcaa gaccttcgtc     3720

gaattaatga aacgaggcga tttgcccgta tggctagcct atcaagtagc gtcggcaggt     3780

ataacctaca cggatcgacg atggtgcttc gatggtacga ccaataatac cataatggaa     3840

gatagtgtgc cggcagaggt gtggaccaga cacggagaga aaagagtgct caaaccgagg     3900

tggatggacg ccagagtttg ttcagatcat gcggccctga agtcattcaa ggagtttgcc     3960

gctgggaaaa gaggagcggc ttttggagtg atggaagccc tgggaacact gccaggacac     4020

atgacagaga gattccagga agccattgac aacctcgctg tgctcatgcg ggcagagact     4080

ggaagcaggc cttacaaagc cgcggcggcc caattgccgg agaccctaga gaccataatg     4140

cttttggggt tgctgggaac agtctcgctg ggaatcttct tcgtcttgat gaggaacaag     4200

ggcataggga agatgggctt tggaatggtg actcttgggg ccagcgcatg gctcatgtgg     4260

ctctcggaaa ttgagccagc cagaattgca tgtgtcctca ttgttgtgtt cctattgctg     4320

gtggtgctca tacctgagcc agaaaagcaa agatctcccc aggacaacca aatggcaatc     4380

atcatcatgg tagcagtagg tcttctgggc ttgattaccg ccaatgaact cggatggttg     4440

gagagaacaa agagtgacct aagccatcta atgggaagga gagaggaggg ggcaaccata     4500

ggattctcaa tggacattga cctgcggcca gcctcagctt gggccatcta tgctgccttg     4560

acaactttca ttaccccagc cgtccaacat gcagtgacca cctcatacaa caactactcc     4620

ttaatggcga tggccacgca agctggagtg ttgtttggta tgggcaaagg gatgccattc     4680

tacgcatggg actttggagt cccgctgcta atgataggtt gctactcaca attaacaccc     4740

ctgaccctaa tagtggccat cattttgctc gtggcgcact acatgtactt gatcccaggg     4800

ctgcaggcag cagctgcgcg tgctgcccag aagagaacgg cagctggcat catgaagaac     4860

cctgttgtgg atggaatagt ggtgactgac attgacacaa tgacaattga cccccaagtg     4920

gagaaaaaga tgggacaggt gctactcata gcagtagccg tctccagcgc catactgtcg     4980

cggaccgcct gggggtgggg ggaggctggg gccctgatca cagccgcaac ttccactttg     5040

tgggaaggct ctccgaacaa gtactggaac tcctctacag ccacttcact gtgtaacatt     5100

tttaggggaa gttacttggc tggagcttct ctaatctaca cagtaacaag aaacgctggc     5160

ttggtcaaga gacgtggggg tggaacagga gagaccctgg gagagaaatg gaaggcccgc     5220

ttgaaccaga tgtcggccct ggagttctac tcctacaaaa agtcaggcat caccgaggtg     5280

tgcagagaag aggcccgccg cgccctcaag gacggtgtgg caacgggagg ccatgctgtg     5340

tcccgaggaa gtgcaaagct gagatggttg gtggagcggg gatacctgca gccctatgga     5400

aaggtcattg atcttggatg tggcagaggg ggctggagtt actacgccgc caccatccgc     5460

aaagttcaag aagtgaaagg atacacaaaa ggaggccctg gtcatgaaga acccgtgttg     5520

gtgcaaagct atgggtggaa catagtccgt cttaagagtg gggtggacgt ctttcatatg     5580

gcggctgagc cgtgtgacac gctgctgtgt gacataggtg agtcatcatc tagtcctgaa     5640

gtggaagaag cacggacgct cagagtcctc tccatggtgg gggattggct tgaaaaaaga     5700

ccaggagcct tttgtataaa agtgttgtgc ccatacacca gcactatgat ggaaaccctg     5760

gagcgactgc agcgtaggta tgggggagga ctggtcagag tgccactctc ccgcaactct     5820

acacatgaga tgtactgggt ctctggagcg aaaagcaaca ccataaaaag tgtgtccacc     5880

acgagccagc tcctcttggg gcgcatggac gggcctagaa ggccagtgaa atatgaggag     5940

gatgtgaatc tcggctctgg cacgcgggct gtggtaagct gcgctgaagc tcccaacatg     6000

aagatcattg gtaaccgcat tgaaaggatc cgcagtgagc acgcggaaac gtggttcttt     6060

gacgagaacc acccatatag gacatgggct taccatggaa gctatgaggc ccccacacaa     6120

gggtcagcgt cctctctaat aaacggggtt gtcaggctcc tgtcaaaacc ctgggatgtg     6180

gtgactggag tcacaggaat agccatgacc gacaccacac cgtatggtca gcaaagagtt     6240

ttcaaggaaa aagtggacac tagggtgcca gacccccaag aaggcactcg tcaggttatg     6300

agcatggtct cttcctggtt gtggaaagag ctaggcaaac acaaacggcc acgagtctgt     6360

accaaagaag agttcatcaa caaggttcgt agcaatgcag cattaggggc aatatttgaa     6420

gaggaaaaag agtggaagac tgcagtggaa gctgtgaacg atccaaggtt ctgggctcta     6480

gtggacaagg aaagagagca ccacctgaga ggagagtgcc agagttgtgt gtataacatg     6540

atgggaaaaa gagaaaagaa acaaggggaa tttggaaagg ccaagggcag ccgcgccatc     6600

tggtatatgt ggctaggggc tagatttcta gagttcgaag cccttggatt cttgaacgag     6660

gatcactgga tggggagaga gaactcagga ggtggtgttg aagggctggg attacaaaga     6720

ctcggatatg tcctagaaga gatgagtcgt ataccaggag gaaggatgta tgcagatgac     6780

actgctggct gggacacccg cattagcagg tttgatctgg agaatgaagc tctaatcacc     6840

aaccaaatgg agaaagggca cagggccttg gcattggcca taatcaagta cacataccaa     6900

aacaaagtgg taaaggtcct tagaccagct gaaaaaggga aaacagttat ggacattatt     6960

tcgagacaag accaaagggg gagcggacaa gttgtcactt acgctcttaa cacatttacc     7020

aacctagtgg tgcaactcat tcggaatatg gaggctgagg aagttctaga gatgcaagac     7080

ttgtggctgc tgcggaggtc agagaaagtg accaactggt tgcagagcaa cggatgggat     7140

aggctcaaac gaatggcagt cagtggagat gattgcgttg tgaagccaat tgatgatagg     7200

tttgcacatg ccctcaggtt cttgaatgat atgggaaaag ttagaaagga cacacaagag     7260

tggaaaccct caactggatg ggacaactgg gaagaagttc cgttttgctc ccaccacttc     7320

aacaagctcc atctcaagga cgggaggtcc attgtggttc cctgccgcca ccaagatgaa     7380

ctgattggcc gggcccgcgt ctctccaggg gcgggatgga gcatccggga gactgcttgc     7440

ctagcaaaat catatgcgca gatgtggcag ctcctttatt tccacagaag ggacctccga     7500

ctgatggcca atgccatttg ttcatctgtg ccagttgact gggttccaac tgggagaact     7560

acctggtcaa tccatggaaa gggagaatgg atgaccactg aagacatgct tgtggtgtgg     7620

aacagagtgt ggattgagga gaacgaccac atggaagaca agaccccagt tacgaaatgg     7680

acagacattc cctatttggg aaaaagggaa gacttgtggt gtggatctct catagggcac     7740

agaccgcgca ccacctgggc tgagaacatt aaaaacacag tcaacatggt gcgcaggatc     7800

ataggtgatg aagaaaagta catggactac ctatccaccc aagttcgcta cttgggtgaa     7860

gaagggtcta cacctggagt gctgtaa                                         7887


<210>  10
<211>  10807
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Vaccine candidate ZIKV-DO-NS3, more extensive sequence of 
       flanking regions

<400>  10
agttgttgat ctgtgtgaat cagactgcga cagttcgagt ttgaagcgaa agctagcaac       60

agtatcaaca ggttttattt tggatttgga aacgagagtt tctggtcatg aaaaacccaa      120

aaaagaaatc cggaggattc cggattgtca atatgctaaa acgcggagta gcccgtgtga      180

gcccctttgg gggcttgaag aggctgccag ccggacttct gctgggtcat gggcccatca      240

ggatggtctt ggcgattcta gcctttttga gattcacggc aatcaagcca tcactgggtc      300

tcatcaatag atggggttca gttgggaaaa aagaggctat ggaaataata aagaagttca      360

agaaagatct ggctgccatg ctgagaataa tcaatgctag gaaggagaag aagagacgag      420

gcgcagatac tagtgtcgga attgttggcc tcctgctgac cacagctatg gcagcggagg      480

tcactagacg tgggagtgca tactatatgt acttggacag aaacgatgct ggggaggcca      540

tatcttttcc aaccacattg gggatgaata agtgttatat acagatcatg gatcttggac      600

acatgtgtga tgccaccatg agctatgaat gccctatgct ggatgagggg gtggaaccag      660

atgacgtcga ttgttggtgc aacacgacgt caacttgggt tgtgtacgga acctgccatc      720

acaaaaaagg tgaagcacgg agatctagaa gagctgtgac gctcccctcc cattccacta      780

ggaagctgca aacgcggtcg caaacctggt tggaatcaag agaatacaca aagcacttga      840

ttagagtcga aaattggata ttcaggaacc ctggcttcgc gttagcagca gctgccatcg      900

cttggctttt gggaagctca acgagccaaa aagtcatata cttggtcatg atactgctga      960

ttgccccggc atacagcatc aggtgcatag gagtcagcaa tagggacttt gtggaaggta     1020

tgtcaggtgg gacttgggtt gatgttgtct tggaacatgg aggttgtgtc accgtaatgg     1080

cacaggacaa accgactgtc gacatagagc tggttacaac aacagtcagc aacatggcgg     1140

aggtaagatc ctactgctat gaggcatcaa tatcagacat ggcttcggac agccgctgcc     1200

caacacaagg tgaagcctac cttgacaagc aatcagacac tcaatatgtc tgcaaaagaa     1260

cgttagtgga cagaggctgg ggaaatggat gtggactttt tggcaaaggg agcctggtga     1320

catgcgctaa gtttgcatgc tccaagaaaa tgaccgggaa gagcatccag ccagagaatc     1380

tggagtaccg gataatgctg tcagttcatg gctcccagca cagtgggatg atcgttaatg     1440

acacaggaca tgaaactgat gagaatagag cgaaagttga gataacgccc aattcaccaa     1500

gagccgaagc caccctgggg ggttttggaa gcctaggact tgattgtgaa ccgaggacag     1560

gccttgactt ttcagatttg tattacttga ctatgaataa caagcactgg ttggttcaca     1620

aggagtggtt ccacgacatt ccattacctt ggcacgctgg ggcagacacc ggaactccac     1680

actggaacaa caaagaagca ctggtagagt tcaaggacgc acatgccaaa aggcaaactg     1740

tcgtggttct agggagtcaa gaaggagcag ttcacacggc ccttgctgga gctctggagg     1800

ctgagatgga tggtgcaaag ggaaggctgt cctctggcca cttgaaatgt cgcctgaaaa     1860

tggataaact tagattgaag ggcgtgtcat actccttgtg tactgcagcg ttcacattca     1920

ccaagatccc ggctgaaaca ctgcacggga cagtcacagt ggaggtacag tacgcaggga     1980

cagatggacc ttgcaaggtt ccagctcaga tggcggtgga catgcaaact ctgaccccag     2040

ttgggaggtt gataaccgct aaccccgtaa tcactgaaag cactgagaac tctaagatga     2100

tgctggaact tgatccacca tttggggact cttacattgt cataggagtc ggggagaaga     2160

agatcaccca ccactggcac aggagtggca gcaccattgg aaaagcattt gaagccactg     2220

tgagaggtgc caagagaatg gcagtcttgg gagacacagc ctgggacttt ggatcagttg     2280

gaggcgctct caactcattg ggcaagggca tccatcaaat ttttggagca gctttcaaat     2340

cattgtttgg aggaatgtcc tggttctcac aaattctcat tggaacgttg ctgatgtggt     2400

tgggtctgaa cacaaagaat ggatctattt cccttatgtg cttggcctta gggggggtgt     2460

tgatcttctt atccacagcc gtctctgctg atgtggggtg ctcggtggac ttctcaaaga     2520

aggagacgag atgcggtaca ggggtgttcg tctataacga cgttgaagcc tggagggaca     2580

ggtacaagta ccatcctgac tccccccgta gattggcagc agcagtcaag caagcctggg     2640

aagatggtat ctgcgggatc tcctctgttt caagaatgga aaacatcatg tggagatcag     2700

tagaagggga gctcaacgca atcctggaag agaatggagt tcaactgacg gtcgttgtgg     2760

gatctgtaaa aaaccccatg tggagaggtc cacagagatt gcccgtgcct gtgaacgagc     2820

tgccccacgg ctggaaggct tgggggaaat cgtacttcgt cagagcagca aagacaaata     2880

acagctttgt cgtggatggt gacacactga aggaatgccc actcaaacat agagcatgga     2940

acagctttct tgtggaggat catgggttcg gggtatttca cactagtgtc tggctcaagg     3000

ttagagaaga ttattcatta gagtgtgatc cagccgttat tggaacagct gttaagggaa     3060

aggaggctgt acacagtgat ctaggctact ggattgagag tgagaagaat gacacatgga     3120

ggctgaagag ggcccatctg atcgagatga aaacatgtga atggccaaag tcccacacat     3180

tgtggacaga tggaatagaa gagagtgatc tgatcatacc caagtcttta gctgggccac     3240

tcagccatca caataccaga gagggctaca ggacccaaat gaaagggcca tggcacagtg     3300

aagagcttga aattcggttt gaggaatgcc caggcactaa ggtccacgtg gaggaaacat     3360

gtggaacaag aggaccatct ctgagatcaa ccactgcaag cggaagggtg atcgaggaat     3420

ggtgctgcag ggagtgcaca atgcccccac tgtcgttccg ggctaaagat ggctgttggt     3480

atggaatgga gataaggccc aggaaagaac cagaaagcaa cttagtaagg tcaatggtga     3540

ctgcaggatc aactgatcac atggaccact tctcccttgg agtgcttgtg atcctgctca     3600

tggtgcagga agggctgaag aagagaatga ccacaaagat catcataagc acatcaatgg     3660

cagtgctggt agctatgatc ctgggaggat tttcaatgag tgacctggct aagcttgcaa     3720

ttttgatggg tgccaccttc gcggaaatga acactggagg agatgtagct catctggcgc     3780

tgatagcggc attcaaagtc agaccagcgt tgctggtatc tttcatcttc agagctaatt     3840

ggacaccccg tgaaagcatg ctgctggcct tggcctcgtg tcttttgcaa actgcgatct     3900

ccgccttgga aggcgacctg atggttctca tcaatggttt tgctttggcc tggttggcaa     3960

tacgagcgat ggttgttcca cgcactgata acatcacctt ggcaatcctg gctgctctga     4020

caccactggc ccggggcaca ctgcttgtgg cgtggagagc aggccttgct acttgcgggg     4080

ggtttatgct cctctctctg aagggaaaag gcagtgtgaa gaagaactta ccatttgtca     4140

tggccctggg actaaccgct gtgaggctgg tcgaccccat caacgtggtg ggactgctgt     4200

tactcacaag gagtgggaag cggagctggc cccctagcga agtactcaca gctgttggcc     4260

tgatatgcgc attggctgga gggttcgcca aggcagatat agagatggct gggcccatgg     4320

ccgcggtcgg tctgctaatt gtcagttacg tggtctcagg aaagagtgtg gacatgtaca     4380

ttgaaagagc aggtgacatc acatgggaaa aagatgcgga agtcactgga aacagtcccc     4440

ggctcgatgt ggcgctagat gagagtggtg atttctccct ggtggaggat gacggtcccc     4500

ccatgagaga gatcatactc aaggtggtcc tgatgaccat ctgtggcatg aatccaatag     4560

ccataccctt tgcagctgga gcgtggtacg tatacgtgaa gactggaaaa aggagtggtg     4620

cgctctggga tgtccccgcg cccaaggaag taaaaaaggg tgagaccacg gatggcgtct     4680

accgagtaat gacccgtcga ctactcggtt cgacgcaagt aggcgtcggc gtaatgcaag     4740

agggtgtatt ccacaccatg tggcatgtaa cgaaaggctc ggcgctacga tccggtgaag     4800

gtcgattgga tccgtactgg ggcgatgtaa agcaagatct agtctcgtac tgtggtccgt     4860

ggaagctcga tgccgcctgg gacggtcact ccgaggtcca gttattggcc gtcccgccgg     4920

gcgagcgagc gcgcaatata caaactctac ccggcatatt caagacgaag gatggtgaca     4980

ttggcgcggt agcgctagat tacccggcgg gcacttcggg ctcgccgata ctcgacaagt     5040

gtggtcgagt cataggcttg tatggtaatg gtgtagtcat aaaaaatggt agttatgtaa     5100

gtgccataac ccaaggtcgc cgcgaagaag agacccccgt agagtgcttc gagccctcga     5160

tgctaaagaa gaagcaactc actgtattag acttgcatcc cggcgcgggt aaaacccgcc     5220

gagtattgcc cgaaatagta cgtgaagcca taaaaacgcg attacgtacc gtcatattag     5280

cgccgacccg cgtagtagcg gcggaaatgg aggaggcctt gcgaggtttg ccagtccgtt     5340

atatgacgac ggcggtaaat gtaacccatt cgggcacgga aatagtagac ttaatgtgcc     5400

atgccacctt cacctcgcgt ctcctccagc cgatacgagt acccaattat aatctatata     5460

ttatggatga ggcccatttc acggatccct cgagtatagc ggcgcgaggc tacatttcga     5520

cgcgcgtaga gatgggtgag gcggcggcca tattcatgac cgccacgccg ccgggcaccc     5580

gtgacgcgtt cccggactcg aattcgccga ttatggacac cgaagtcgaa gtaccggagc     5640

gagcctggtc ctcgggtttt gattgggtca cggatcattc gggcaaaacg gtatggttcg     5700

taccgtccgt ccgcaatggt aatgagatag cggcgtgtct aacgaaggcg ggcaaacggg     5760

taatacagtt atcccgaaag accttcgaga cggagttcca aaaaacgaaa catcaagagt     5820

gggacttcgt agtcacgacc gacatttcgg agatgggtgc caatttcaaa gcagaccgtg     5880

taatagattc gcgccgatgc ctcaagccgg taatattgga tggtgagcga gtaattctag     5940

cgggccccat gcccgtaacg catgcctccg cggcccaacg ccgcggtcgc ataggtcgca     6000

atcccaataa acccggcgat gagtatctat atggcggtgg ttgcgcggag accgacgaag     6060

accatgcgca ttggttggaa gcgcgaatgt tattggacaa tatttactta caagatggtt     6120

taatagcctc gttatatcga cccgaggccg acaaagtagc ggccattgag ggcgagttca     6180

agttgcgcac ggagcaacgc aagaccttcg tcgaattaat gaaacgaggc gatttgcccg     6240

tatggctagc ctatcaagta gcgtcggcag gtataaccta cacggatcga cgatggtgct     6300

tcgatggtac gaccaataat accataatgg aagatagtgt gccggcagag gtgtggacca     6360

gacacggaga gaaaagagtg ctcaaaccga ggtggatgga cgccagagtt tgttcagatc     6420

atgcggccct gaagtcattc aaggagtttg ccgctgggaa aagaggagcg gcttttggag     6480

tgatggaagc cctgggaaca ctgccaggac acatgacaga gagattccag gaagccattg     6540

acaacctcgc tgtgctcatg cgggcagaga ctggaagcag gccttacaaa gccgcggcgg     6600

cccaattgcc ggagacccta gagaccataa tgcttttggg gttgctggga acagtctcgc     6660

tgggaatctt cttcgtcttg atgaggaaca agggcatagg gaagatgggc tttggaatgg     6720

tgactcttgg ggccagcgca tggctcatgt ggctctcgga aattgagcca gccagaattg     6780

catgtgtcct cattgttgtg ttcctattgc tggtggtgct catacctgag ccagaaaagc     6840

aaagatctcc ccaggacaac caaatggcaa tcatcatcat ggtagcagta ggtcttctgg     6900

gcttgattac cgccaatgaa ctcggatggt tggagagaac aaagagtgac ctaagccatc     6960

taatgggaag gagagaggag ggggcaacca taggattctc aatggacatt gacctgcggc     7020

cagcctcagc ttgggccatc tatgctgcct tgacaacttt cattacccca gccgtccaac     7080

atgcagtgac cacctcatac aacaactact ccttaatggc gatggccacg caagctggag     7140

tgttgtttgg tatgggcaaa gggatgccat tctacgcatg ggactttgga gtcccgctgc     7200

taatgatagg ttgctactca caattaacac ccctgaccct aatagtggcc atcattttgc     7260

tcgtggcgca ctacatgtac ttgatcccag ggctgcaggc agcagctgcg cgtgctgccc     7320

agaagagaac ggcagctggc atcatgaaga accctgttgt ggatggaata gtggtgactg     7380

acattgacac aatgacaatt gacccccaag tggagaaaaa gatgggacag gtgctactca     7440

tagcagtagc cgtctccagc gccatactgt cgcggaccgc ctgggggtgg ggggaggctg     7500

gggccctgat cacagccgca acttccactt tgtgggaagg ctctccgaac aagtactgga     7560

actcctctac agccacttca ctgtgtaaca tttttagggg aagttacttg gctggagctt     7620

ctctaatcta cacagtaaca agaaacgctg gcttggtcaa gagacgtggg ggtggaacag     7680

gagagaccct gggagagaaa tggaaggccc gcttgaacca gatgtcggcc ctggagttct     7740

actcctacaa aaagtcaggc atcaccgagg tgtgcagaga agaggcccgc cgcgccctca     7800

aggacggtgt ggcaacggga ggccatgctg tgtcccgagg aagtgcaaag ctgagatggt     7860

tggtggagcg gggatacctg cagccctatg gaaaggtcat tgatcttgga tgtggcagag     7920

ggggctggag ttactacgcc gccaccatcc gcaaagttca agaagtgaaa ggatacacaa     7980

aaggaggccc tggtcatgaa gaacccgtgt tggtgcaaag ctatgggtgg aacatagtcc     8040

gtcttaagag tggggtggac gtctttcata tggcggctga gccgtgtgac acgctgctgt     8100

gtgacatagg tgagtcatca tctagtcctg aagtggaaga agcacggacg ctcagagtcc     8160

tctccatggt gggggattgg cttgaaaaaa gaccaggagc cttttgtata aaagtgttgt     8220

gcccatacac cagcactatg atggaaaccc tggagcgact gcagcgtagg tatgggggag     8280

gactggtcag agtgccactc tcccgcaact ctacacatga gatgtactgg gtctctggag     8340

cgaaaagcaa caccataaaa agtgtgtcca ccacgagcca gctcctcttg gggcgcatgg     8400

acgggcctag aaggccagtg aaatatgagg aggatgtgaa tctcggctct ggcacgcggg     8460

ctgtggtaag ctgcgctgaa gctcccaaca tgaagatcat tggtaaccgc attgaaagga     8520

tccgcagtga gcacgcggaa acgtggttct ttgacgagaa ccacccatat aggacatggg     8580

cttaccatgg aagctatgag gcccccacac aagggtcagc gtcctctcta ataaacgggg     8640

ttgtcaggct cctgtcaaaa ccctgggatg tggtgactgg agtcacagga atagccatga     8700

ccgacaccac accgtatggt cagcaaagag ttttcaagga aaaagtggac actagggtgc     8760

cagaccccca agaaggcact cgtcaggtta tgagcatggt ctcttcctgg ttgtggaaag     8820

agctaggcaa acacaaacgg ccacgagtct gtaccaaaga agagttcatc aacaaggttc     8880

gtagcaatgc agcattaggg gcaatatttg aagaggaaaa agagtggaag actgcagtgg     8940

aagctgtgaa cgatccaagg ttctgggctc tagtggacaa ggaaagagag caccacctga     9000

gaggagagtg ccagagttgt gtgtataaca tgatgggaaa aagagaaaag aaacaagggg     9060

aatttggaaa ggccaagggc agccgcgcca tctggtatat gtggctaggg gctagatttc     9120

tagagttcga agcccttgga ttcttgaacg aggatcactg gatggggaga gagaactcag     9180

gaggtggtgt tgaagggctg ggattacaaa gactcggata tgtcctagaa gagatgagtc     9240

gtataccagg aggaaggatg tatgcagatg acactgctgg ctgggacacc cgcattagca     9300

ggtttgatct ggagaatgaa gctctaatca ccaaccaaat ggagaaaggg cacagggcct     9360

tggcattggc cataatcaag tacacatacc aaaacaaagt ggtaaaggtc cttagaccag     9420

ctgaaaaagg gaaaacagtt atggacatta tttcgagaca agaccaaagg gggagcggac     9480

aagttgtcac ttacgctctt aacacattta ccaacctagt ggtgcaactc attcggaata     9540

tggaggctga ggaagttcta gagatgcaag acttgtggct gctgcggagg tcagagaaag     9600

tgaccaactg gttgcagagc aacggatggg ataggctcaa acgaatggca gtcagtggag     9660

atgattgcgt tgtgaagcca attgatgata ggtttgcaca tgccctcagg ttcttgaatg     9720

atatgggaaa agttagaaag gacacacaag agtggaaacc ctcaactgga tgggacaact     9780

gggaagaagt tccgttttgc tcccaccact tcaacaagct ccatctcaag gacgggaggt     9840

ccattgtggt tccctgccgc caccaagatg aactgattgg ccgggcccgc gtctctccag     9900

gggcgggatg gagcatccgg gagactgctt gcctagcaaa atcatatgcg cagatgtggc     9960

agctccttta tttccacaga agggacctcc gactgatggc caatgccatt tgttcatctg    10020

tgccagttga ctgggttcca actgggagaa ctacctggtc aatccatgga aagggagaat    10080

ggatgaccac tgaagacatg cttgtggtgt ggaacagagt gtggattgag gagaacgacc    10140

acatggaaga caagacccca gttacgaaat ggacagacat tccctatttg ggaaaaaggg    10200

aagacttgtg gtgtggatct ctcatagggc acagaccgcg caccacctgg gctgagaaca    10260

ttaaaaacac agtcaacatg gtgcgcagga tcataggtga tgaagaaaag tacatggact    10320

acctatccac ccaagttcgc tacttgggtg aagaagggtc tacacctgga gtgctgtaag    10380

caccaatctt aatgttgtca ggcctgctag tcagccacag cttggggaaa gctgtgcagc    10440

ctgtgacccc ccaggagaag ctgggaaacc aagcctatag tcaggccgag aacgccatgg    10500

cacggaagaa gccatgctgc ctgtgagccc ctcagaggat actgagtcaa aaaaccccac    10560

gcgcttggag gcgcaggatg ggaaaagaag gtggcgacct tccccaccct tcaatctggg    10620

gcctgaactg gagatcagct gtggatcccc agaagaggga ctagtggtta gaggagaccc    10680

cccggaaaac gcaaaacagc atattgacgc tgggaaagac cagagactcc atgagtttcc    10740

accacgctgg ccgccaggca cagatcgccg aacttcggcg gccggtgtgg ggaaatccat    10800

ggtttct                                                              10807


<210>  11
<211>  10807
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Vaccine candidate ZIKV-DO-scattered, more extensive sequence of 
       flanking regions

<400>  11
agttgttgat ctgtgtgaat cagactgcga cagttcgagt ttgaagcgaa agctagcaac       60

agtatcaaca ggttttattt tggatttgga aacgagagtt tctggtcatg aaaaacccaa      120

aaaagaaatc cggaggattc cggattgtca atatgctaaa acgcggagta gcccgtgtga      180

gcccctttgg gggcttgaag aggctgccag ccggacttct gctgggtcat gggcccatca      240

ggatggtctt ggcgattcta gcctttttga gattcacggc aatcaagcca tcactgggtc      300

tcatcaatag atggggttca gttgggaaaa aagaggctat ggaaataata aagaagttca      360

agaaagatct ggctgccatg ctgagaataa tcaatgctag gaaggagaag aagagacgag      420

gcgcagatac tagtgtcgga attgttggcc tcctgctgac cacagctatg gcagcggagg      480

tcactagacg tgggagtgca tactatatgt acttggacag aaacgatgct ggggaggcca      540

tatcttttcc aaccacattg gggatgaata agtgttatat acagatcatg gatcttggac      600

acatgtgtga tgccaccatg agctatgaat gccctatgct ggatgagggg gtggaaccag      660

atgacgtcga ttgttggtgc aacacgacgt caacttgggt tgtgtacgga acctgccatc      720

acaaaaaagg tgaagcacgg agatctagaa gagctgtgac gctcccctcc cattccacta      780

ggaagctgca aacgcggtcg caaacctggt tggaatcaag agaatacaca aagcacttga      840

ttagagtcga aaattggata ttcaggaacc ctggcttcgc gttagcagca gctgccatcg      900

cttggctttt gggaagctca acgagccaaa aagtcatata cttggtcatg atactgctga      960

ttgccccggc atacagcatc aggtgcatag gagtcagcaa tagggacttt gtggaaggta     1020

tgtcaggtgg gacttgggtt gatgttgtct tggaacatgg aggttgtgtc accgtaatgg     1080

cacaggacaa accgactgtc gacatagagc tggttacaac aacagtcagc aacatggcgg     1140

aggtaagatc ctactgctat gaggcatcaa tatcagacat ggcttcggac agccgctgcc     1200

caacacaagg tgaagcctac cttgacaagc aatcagacac tcaatatgtc tgcaaaagaa     1260

cgttagtgga cagaggctgg ggaaatggat gtggactttt tggcaaaggg agcctggtga     1320

catgcgctaa gtttgcatgc tccaagaaaa tgaccgggaa gagcatccag ccagagaatc     1380

tggagtaccg gataatgctg tcagttcatg gctcccagca cagtgggatg atcgttaatg     1440

acacaggaca tgaaactgat gagaatagag cgaaagttga gataacgccc aattcaccaa     1500

gagccgaagc caccctgggg ggttttggaa gcctaggact tgattgtgaa ccgaggacag     1560

gccttgactt ttcagatttg tattacttga ctatgaataa caagcactgg ttggttcaca     1620

aggagtggtt ccacgacatt ccattacctt ggcacgctgg ggcagacacc ggaactccac     1680

actggaacaa caaagaagca ctggtagagt tcaaggacgc acatgccaaa aggcaaactg     1740

tcgtggttct agggagtcaa gaaggagcag ttcacacggc ccttgctgga gctctggagg     1800

ctgagatgga tggtgcaaag ggaaggctgt cctctggcca cttgaaatgt cgcctgaaaa     1860

tggataaact tagattgaag ggcgtgtcat actccttgtg tactgcagcg ttcacattca     1920

ccaagatccc ggctgaaaca ctgcacggga cagtcacagt ggaggtacag tacgcaggga     1980

cagatggacc ttgcaaggtt ccagctcaga tggcggtgga catgcaaact ctgaccccag     2040

ttgggaggtt gataaccgct aaccccgtaa tcactgaaag cactgagaac tctaagatga     2100

tgctggaact tgatccacca tttggggact cttacattgt cataggagtc ggggagaaga     2160

agatcaccca ccactggcac aggagtggca gcaccattgg aaaagcattt gaagccactg     2220

tgagaggtgc caagagaatg gcagtcttgg gagacacagc ctgggacttt ggatcagttg     2280

gaggcgctct caactcattg ggcaagggca tccatcaaat ttttggagca gctttcaaat     2340

cattgtttgg aggaatgtcc tggttctcac aaattctcat tggaacgttg ctgatgtggt     2400

tgggtctgaa cacaaagaat ggatctattt cccttatgtg cttggcctta gggggggtgt     2460

tgatcttctt atccacagcc gtctctgctg atgtagggtg ctcggtagac ttctcaaaga     2520

aggaaacgag atgcggtacg ggggtattcg tctataacga tgttgaagcc tggcgtgaca     2580

ggtacaaata ccatcctgat tccccccgtc gattggcagc agcggtcaag caagcgtggg     2640

aagatggtat atgcgggatc tcgtctgttt cacgtatgga aaacataatg tggagatcgg     2700

tagaagggga gctaaacgca atcctagaag agaatggtgt tcaactgacg gtagttgtag     2760

gatctgtaaa aaacccgatg tggagaggtc cgcagagatt gccggtacct gtaaacgagc     2820

tgccccacgg ttggaaggct tggggtaaat cgtacttcgt aagagcagca aaaacaaata     2880

actcgtttgt cgtggatggt gatacactga aggaatgtcc actcaaacat cgtgcatgga     2940

actcgtttct tgtagaggat catggtttcg gggtatttca tactagtgtc tggctaaagg     3000

ttagagaaga ttattcgtta gagtgtgatc cggccgttat tggtacagct gttaaaggaa     3060

aggaggcggt acacagtgat ctaggttact ggattgaaag tgagaagaat gatacatgga     3120

ggctaaagag ggcccatcta atcgagatga aaacgtgtga atggccgaag tcccacacgt     3180

tgtggacaga tggtatagaa gagtcggatc tgatcatacc gaagtcttta gcggggccac     3240

tcagtcatca caatacgaga gagggctata ggacccaaat gaaaggtcca tggcactcgg     3300

aagagcttga aatacggttt gaggaatgtc caggcactaa agtccacgtg gaagaaacat     3360

gtggtacaag aggaccgtct ctgagatcga ccactgcaag tggaagggta atcgaggaat     3420

ggtgttgcag ggagtgcacg atgcccccac tatcgttccg ggcgaaagat ggctgttggt     3480

atggtatgga gatacgtccc aggaaagaac cggaaagcaa cttagtacgt tcaatggtaa     3540

ctgcaggatc gactgatcac atggatcact tctcccttgg agtacttgta atcctgctca     3600

tggtacagga agggctaaag aagagaatga cgacaaagat cataataagc acatcgatgg     3660

cagtactggt agctatgata ctgggaggat tttcgatgag tgacctagct aagcttgcga     3720

ttttgatggg tgcgaccttc gcggaaatga atactggagg agatgtagcg catctggcgc     3780

taatagcggc atttaaagtc agaccggcgt tgctggtatc gttcatcttc cgtgctaatt     3840

ggacgccccg tgaatcgatg ctgctggcgt tggcctcgtg tctattgcaa actgcgatat     3900

ccgccttgga aggtgacctg atggtactca tcaatggttt tgcgttggcc tggttagcaa     3960

tacgagcgat ggtagttcca cgcacggata acatcacgtt ggcaatccta gctgctctga     4020

cgccactggc ccgtggcaca ctgcttgtag cgtggagagc gggccttgct acgtgcgggg     4080

ggtttatgct actctctctg aaaggaaaag gcagtgtaaa gaagaactta ccgtttgtca     4140

tggcgctggg actaacggct gtaaggctgg tcgatcccat caacgtagta ggactgctgt     4200

tactaacaag gagtgggaaa cggagctggc cgcctagcga agtactaaca gctgttggtc     4260

tgatatgcgc attggcggga gggttcgcga aggcagatat agaaatggct gggccgatgg     4320

ccgcggtagg tctgctaata gtcagttacg tagtctcagg aaaaagtgtg gacatgtata     4380

ttgaaagagc gggtgacatc acatgggaaa aagatgcgga agtaactgga aacagtccgc     4440

ggctcgatgt agcgctagat gaaagtggtg atttttccct ggtagaggat gacggtcccc     4500

ccatgagaga aatcatactc aaagtagtcc tgatgacgat ctgtggcatg aatccgatag     4560

ccataccgtt tgcagctggt gcgtggtacg tatacgtaaa gactggaaaa cgtagtggtg     4620

ctctatggga tgtacctgct cccaaagaag taaaaaaagg ggagaccacg gatggagtat     4680

acagagtaat gacgcgtaga ctgctaggtt cgacacaagt tggtgtagga gttatgcaag     4740

aaggggtctt tcatactatg tggcatgtca caaaaggttc cgcgctgcgt agcggtgaag     4800

gtagacttga tccgtactgg ggagatgtaa agcaggatct agtatcatac tgtggtccgt     4860

ggaagctaga tgcggcctgg gacggtcaca gcgaggtaca gctcttggcg gtaccccccg     4920

gagaaagagc gaggaatatc cagactctac ccggaatatt taaaacaaag gatggtgaca     4980

ttggagcggt agcgctggat tatccagcag gaacgtcagg atctccgatc ctagacaaat     5040

gtgggagagt aataggactt tatggtaatg gggtcgtaat caaaaatggt agttatgtta     5100

gtgcgatcac ccaaggtagg agggaagaag aaactcctgt tgaatgcttc gagccgtcga     5160

tgctgaaaaa gaagcagcta acggtcttag acttacatcc tggagcgggg aaaacccgaa     5220

gagttcttcc ggaaatagtc cgtgaagcga taaaaacacg tctccgtact gtaatcttag     5280

ctccgaccag ggttgtagct gctgaaatgg aagaggccct tcgtgggctt ccagtacgtt     5340

atatgacgac agcagtcaat gtaacccact ctggtacaga aatcgttgac ttaatgtgtc     5400

atgccacctt tacttcacgt ctactacaac caatcagagt tcccaactat aatctatata     5460

ttatggatga agcccacttc acggatccct caagtatagc ggcaagagga tatatttcaa     5520

caagggttga aatgggcgag gcggcggcca tcttcatgac ggccacgcca ccgggaaccc     5580

gtgatgcatt tccggattcc aactcaccga ttatggacac ggaagtggaa gttccagaga     5640

gagcgtggag ctcaggtttt gattgggtaa cggatcattc gggaaaaaca gtttggtttg     5700

ttccgagcgt gaggaatggc aatgagatag cagcttgtct aacaaaggct ggtaaacggg     5760

tcatacaact cagcagaaaa acttttgaaa cagagttcca aaaaacaaaa catcaagaat     5820

gggactttgt tgttacaact gacatatcag agatgggtgc caactttaaa gctgaccgtg     5880

tcatagattc gaggagatgc ctaaagccgg tcatactaga tggcgagcga gtcattctgg     5940

cgggacccat gccggtcaca catgcgagcg ctgcccaaag gagggggcgt ataggcagga     6000

atccgaacaa acctggtgat gagtatctat atggaggtgg ttgcgcagag acggacgaag     6060

accatgcgca ctggcttgaa gcgagaatgc tcctagacaa tatttatctc caagatggtc     6120

tcatagcctc gctatatcga cctgaagccg acaaagtagc ggccattgag ggtgagttca     6180

agctaaggac ggagcaacgt aagacctttg tagaactcat gaaaagaggt gatcttcctg     6240

tatggctggc ctatcaagtt gcatctgcgg gaataaccta tacagataga agatggtgtt     6300

ttgatggcac gacgaacaac accataatgg aagattcggt gccggcagaa gtgtggacca     6360

gacatggaga gaaacgtgtg ctcaaaccga ggtggatgga tgccagagtt tgttcagatc     6420

atgcggcgct gaagtcattt aaggagtttg cggctgggaa aagaggtgcg gcttttggtg     6480

taatggaagc cctgggaaca ctgccgggac acatgacgga gagattccaa gaagccattg     6540

ataacctcgc tgtactcatg cgggcggaga ctggaagtag gccttacaaa gccgcggcgg     6600

cgcaattgcc ggaaacccta gagacgataa tgcttttagg gttgctgggt acagtctcgc     6660

taggaatctt ctttgtcttg atgcgtaaca agggcatagg taagatgggc tttggtatgg     6720

tgactctagg ggccagcgcg tggctcatgt ggctatcgga aattgaacca gccagaatag     6780

catgtgtcct aattgttgta ttcctattgc tggtagtact catacctgaa ccagaaaagc     6840

aacgttctcc ccaggataac caaatggcaa taatcatcat ggtagcggta ggtcttctag     6900

gcttgattac ggccaatgaa ctaggatggt tggaaagaac aaagtcggac ctaagccatc     6960

taatgggtag gagagaggaa ggggcaacca taggtttctc aatggatatt gacctgcgtc     7020

cagcctcagc gtgggccatc tatgcggcct tgacaacgtt cattaccccg gccgtccaac     7080

atgcggtgac cacctcgtac aacaactatt ccttaatggc gatggcgacg caagctggtg     7140

tgttgtttgg tatgggtaaa gggatgccgt tctacgcatg ggattttgga gtcccgctac     7200

taatgatagg ttgttactca caattaacgc ccctgaccct aatagtagcc atcattttac     7260

tcgtggcgca ttacatgtac ttaatcccag ggctacaggc agcagcggcg cgtgctgcgc     7320

agaagagaac ggcggctggc atcatgaaaa accctgttgt agatggaata gtagtgactg     7380

acatagacac aatgacgatt gacccccaag tagagaaaaa gatgggtcag gtgctactaa     7440

tagcagtagc ggtctccagc gcgatactgt cgcggaccgc ctggggttgg ggggaggcgg     7500

gggccctgat aacagccgca acgtccactt tgtgggaagg ttctccgaac aaatactgga     7560

actcgtctac agccacgtca ctgtgtaata tttttagggg tagttacttg gcgggagctt     7620

ctctaatata cacagtaacg agaaacgctg gtttggtcaa gcgtcgtggg ggtggtacag     7680

gagagacgct gggagagaaa tggaaagccc gcttgaatca gatgtcggcg ctggagttct     7740

attcctacaa aaaatcaggc atcacggagg tgtgccgtga agaggcccgt cgcgccctca     7800

aagacggtgt ggcgacggga ggccatgcgg tgtcccgagg tagtgcaaag ctaagatggt     7860

tggtagagcg gggatatctg cagccctatg gtaaggtcat tgatctagga tgtggccgtg     7920

ggggctggtc gtactacgcc gcgaccatcc gcaaagtaca agaagtgaaa ggttacacaa     7980

aaggtggccc tggtcatgaa gaacccgtgt tggtgcaaag ttatgggtgg aatatagtcc     8040

gtctaaagag tggggtagac gtctttcata tggcggcgga gccgtgtgat acgctgctgt     8100

gtgatatagg tgagtcgtca tctagtccgg aagtggaaga agcgcggacg ctccgtgtcc     8160

tctccatggt aggggattgg ctagaaaaaa gaccgggagc cttttgtata aaagtattgt     8220

gcccatatac cagcactatg atggaaacgc tggagcgact acagcgtagg tatggtggag     8280

gactggtaag agtgccacta tcccgcaact cgacacatga gatgtattgg gtctctggtg     8340

cgaaaagcaa taccataaaa agtgtatcca ccacgtcgca gctcctctta gggcgcatgg     8400

atgggcctag acgtccagtg aaatatgaag aggatgtgaa tctaggctct ggcacgcgtg     8460

ctgtggtaag ttgcgctgaa gcgcccaaca tgaaaatcat tggtaatcgc attgaaagga     8520

tacgcagtga gcatgcggaa acgtggtttt ttgacgagaa tcacccatat aggacgtggg     8580

cttaccatgg tagctatgag gcgcccacac aaggttcagc gtcctcgcta ataaacggtg     8640

ttgtcaggct actgtcaaaa ccgtgggatg tggtaactgg agtcacggga atagccatga     8700

cggacaccac accgtatggt caacaaagag tttttaagga aaaagtagac actagggtac     8760

cagaccccca agaaggtact cgtcaggtaa tgagcatggt atcttcctgg ttatggaaag     8820

agctaggtaa acacaaacgt ccacgagtct gtacgaaaga agagtttatc aacaaggtac     8880

gtagcaatgc ggcattaggg gcgatatttg aagaagaaaa agagtggaaa actgcagtgg     8940

aagcggtgaa cgatccgagg ttctgggcgc tagtggacaa agaaagagag catcacctga     9000

gaggtgagtg ccagtcgtgt gtgtataata tgatgggaaa acgtgaaaag aaacaaggtg     9060

aatttggaaa agccaagggc agccgtgcca tctggtatat gtggctaggt gctagatttc     9120

tagaattcga agcccttgga ttcttgaatg aggatcactg gatgggtaga gagaactcgg     9180

gaggtggtgt agaagggctg ggtttacaaa gactaggata tgtcctagaa gaaatgagtc     9240

gtataccggg aggaaggatg tatgcggatg acactgcggg ctgggacacg cgcattagcc     9300

gttttgatct ggaaaatgaa gctctaataa ccaaccaaat ggaaaaaggg cacagggcgt     9360

tggcattggc gataatcaag tatacatacc aaaataaagt ggtaaaagtc cttagaccgg     9420

ctgaaaaagg taaaacagtt atggatatta tttcgcgtca agaccaaagg ggtagcggac     9480

aagtagtcac ttacgcgctt aacacattta cgaacctagt ggtacaactc attcgtaata     9540

tggaggcgga ggaagttcta gaaatgcaag acttatggct gctgcgtagg tcagagaaag     9600

taaccaactg gttacagagc aacggttggg ataggctaaa acgaatggcg gtcagtggag     9660

atgattgtgt tgtgaagccg attgatgatc gttttgcaca tgcgctcagg ttcttaaatg     9720

atatgggtaa agttagaaaa gacacacaag aatggaaacc ctcgactgga tgggataact     9780

gggaagaagt accgttttgc tcgcaccact tcaataagct ccatctaaag gacgggcgtt     9840

ccattgtggt accctgccgc catcaagatg aactaattgg ccgggcgcgc gtctctccgg     9900

gggcgggatg gtcgatccgg gagacggctt gcctagcgaa atcatatgcg caaatgtggc     9960

agctacttta tttccataga agggacctac gactgatggc gaatgccatt tgttcgtctg    10020

tgccagtaga ctgggttccg actgggagaa cgacctggtc aatacatgga aagggtgaat    10080

ggatgacgac tgaagacatg ctagtggtgt ggaatagagt gtggatagag gagaacgatc    10140

acatggaaga taagacccca gtaacgaaat ggacggacat tccctattta ggaaaaaggg    10200

aagatttgtg gtgtggttct ctcataggtc acagaccgcg taccacctgg gcggagaaca    10260

ttaaaaatac agtcaacatg gtacgcagga tcataggtga tgaagaaaaa tatatggact    10320

acctatcgac ccaagttcgt tacttgggtg aagaaggttc tacacctggt gtgctgtaag    10380

caccaatctt aatgttgtca ggcctgctag tcagccacag cttggggaaa gctgtgcagc    10440

ctgtgacccc ccaggagaag ctgggaaacc aagcctatag tcaggccgag aacgccatgg    10500

cacggaagaa gccatgctgc ctgtgagccc ctcagaggat actgagtcaa aaaaccccac    10560

gcgcttggag gcgcaggatg ggaaaagaag gtggcgacct tccccaccct tcaatctggg    10620

gcctgaactg gagatcagct gtggatcccc agaagaggga ctagtggtta gaggagaccc    10680

cccggaaaac gcaaaacagc atattgacgc tgggaaagac cagagactcc atgagtttcc    10740

accacgctgg ccgccaggca cagatcgccg aacttcggcg gccggtgtgg ggaaatccat    10800

ggtttct                                                              10807


<210>  12
<211>  10807
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Vaccine candidate ZIKV-DO, more extensive sequence of flanking 
       regions

<400>  12
agttgttgat ctgtgtgaat cagactgcga cagttcgagt ttgaagcgaa agctagcaac       60

agtatcaaca ggttttattt tggatttgga aacgagagtt tctggtcatg aaaaacccaa      120

aaaagaaatc cggaggattc cggattgtca atatgctaaa acgcggagta gcccgtgtga      180

gcccctttgg gggcttgaag aggctgccag ccggacttct gctgggtcat gggcccatca      240

ggatggtctt ggcgattcta gcctttttga gattcacggc aatcaagcca tcactgggtc      300

tcatcaatag atggggttca gttgggaaaa aagaggctat ggaaataata aagaagttca      360

agaaagatct ggctgccatg ctgagaataa tcaatgctag gaaggagaag aagagacgag      420

gcgcagatac tagtgtcgga attgttggcc tcctgctgac cacagctatg gcagcggagg      480

tcactagacg tgggagtgca tactatatgt acttggacag aaacgatgct ggggaggcca      540

tatcttttcc aaccacattg gggatgaata agtgttatat acagatcatg gatcttggac      600

acatgtgtga tgccaccatg agctatgaat gccctatgct ggatgagggg gtggaaccag      660

atgacgtcga ttgttggtgc aacacgacgt caacttgggt tgtgtacgga acctgccatc      720

acaaaaaagg tgaagcacgg agatctagaa gagctgtgac gctcccctcc cattccacta      780

ggaagctgca aacgcggtcg caaacctggt tggaatcaag agaatacaca aagcacttga      840

ttagagtcga aaattggata ttcaggaacc ctggcttcgc gttagcagca gctgccatcg      900

cttggctttt gggaagctca acgagccaaa aagtcatata cttggtcatg atactgctga      960

ttgccccggc atacagcatc aggtgcatag gagtcagcaa tagggacttt gtggaaggta     1020

tgtcaggtgg gacttgggtt gatgttgtct tggaacatgg aggttgtgtc accgtaatgg     1080

cacaggacaa accgactgtc gacatagagc tggttacaac aacagtcagc aacatggcgg     1140

aggtaagatc ctactgctat gaggcatcaa tatcagacat ggcttcggac agccgctgcc     1200

caacacaagg tgaagcctac cttgacaagc aatcagacac tcaatatgtc tgcaaaagaa     1260

cgttagtgga cagaggctgg ggaaatggat gtggactttt tggcaaaggg agcctggtga     1320

catgcgctaa gtttgcatgc tccaagaaaa tgaccgggaa gagcatccag ccagagaatc     1380

tggagtaccg gataatgctg tcagttcatg gctcccagca cagtgggatg atcgttaatg     1440

acacaggaca tgaaactgat gagaatagag cgaaagttga gataacgccc aattcaccaa     1500

gagccgaagc caccctgggg ggttttggaa gcctaggact tgattgtgaa ccgaggacag     1560

gccttgactt ttcagatttg tattacttga ctatgaataa caagcactgg ttggttcaca     1620

aggagtggtt ccacgacatt ccattacctt ggcacgctgg ggcagacacc ggaactccac     1680

actggaacaa caaagaagca ctggtagagt tcaaggacgc acatgccaaa aggcaaactg     1740

tcgtggttct agggagtcaa gaaggagcag ttcacacggc ccttgctgga gctctggagg     1800

ctgagatgga tggtgcaaag ggaaggctgt cctctggcca cttgaaatgt cgcctgaaaa     1860

tggataaact tagattgaag ggcgtgtcat actccttgtg tactgcagcg ttcacattca     1920

ccaagatccc ggctgaaaca ctgcacggga cagtcacagt ggaggtacag tacgcaggga     1980

cagatggacc ttgcaaggtt ccagctcaga tggcggtgga catgcaaact ctgaccccag     2040

ttgggaggtt gataaccgct aaccccgtaa tcactgaaag cactgagaac tctaagatga     2100

tgctggaact tgatccacca tttggggact cttacattgt cataggagtc ggggagaaga     2160

agatcaccca ccactggcac aggagtggca gcaccattgg aaaagcattt gaagccactg     2220

tgagaggtgc caagagaatg gcagtcttgg gagacacagc ctgggacttt ggatcagttg     2280

gaggcgctct caactcattg ggcaagggca tccatcaaat ttttggagca gctttcaaat     2340

cattgtttgg aggaatgtcc tggttctcac aaattctcat tggaacgttg ctgatgtggt     2400

tgggtctgaa cacaaagaat ggatctattt cccttatgtg cttggcctta gggggggtgt     2460

tgatcttctt atccacagcc gtctctgctg atgtcggttg ttcggtagat ttttcgaaaa     2520

aagaaacgcg atgtggtacg ggtgtatttg tatataatga cgtagaagcg tggcgagacc     2580

gatacaagta tcatccggac tcgccgcgac gattagcggc ggcggtaaaa caagcgtggg     2640

aagacggtat atgcggtata tcgtcggtat cgcgaatgga aaatataatg tggcgatcgg     2700

tagaaggtga gttaaatgcg atactagaag agaatggcgt acaactaacg gtagtagtcg     2760

gctcggtaaa aaatcccatg tggcgaggtc cgcagcgatt gcccgtcccc gtcaatgagc     2820

taccccatgg ttggaaggcg tggggtaaat cgtacttcgt acgagcggcg aagacgaata     2880

attcctttgt agtcgatggt gacacgctaa aggaatgccc gttaaaacat cgagcgtgga     2940

attccttttt ggtcgaggat catggtttcg gtgtattcca taccagtgta tggttaaagg     3000

tacgagaaga ttattcgtta gagtgtgatc cggccgtaat tggcacggcg gtaaagggca     3060

aggaggcggt acatagtgat ctcggttact ggattgagag tgagaagaat gacacgtggc     3120

gcctaaagcg cgcccatcta atagagatga aaacgtgtga atggccgaag tcgcacacgt     3180

tgtggacgga tggcatagaa gagagtgatc taataatacc caagtcgtta gcgggtccgt     3240

tatcccatca taatacccga gagggttacc gcacccaaat gaaaggtccg tggcatagtg     3300

aagagttgga aattcggttc gaggaatgtc cgggtaccaa ggtacacgtc gaggaaacgt     3360

gtggcacgcg aggcccgtcg ctacgatcga ccaccgcgtc cggccgcgtc atagaggaat     3420

ggtgctgccg cgagtgcacg atgcccccgc tatcgttccg ggcgaaagat ggttgttggt     3480

atggaatgga gatacgcccc cgcaaagaac cggaatccaa tttagtacgc tcgatggtca     3540

ccgcgggctc gaccgatcat atggaccatt tctcgttggg cgtcttggtc atactattaa     3600

tggtccaaga aggtctaaag aagcgaatga ccacgaagat aataatatcc acgtcgatgg     3660

cggtcctagt agcgatgata ctaggcggct tttcgatgag tgacctagcg aagttggcga     3720

ttttgatggg tgccaccttc gcggaaatga ataccggcgg cgatgtagcg catctagcgc     3780

taatagcggc gttcaaagta cgaccggcgt tgctagtatc gttcatattc cgagcgaatt     3840

ggacgccccg tgaatccatg ctactagcct tggcctcgtg tttgttgcaa accgcgatat     3900

cggccttgga aggtgaccta atggtattaa taaatggttt cgcgttggcc tggttggcga     3960

tacgagcgat ggtagtaccg cgcaccgata atataacctt ggcgatacta gcggcgctaa     4020

cgccgctagc ccggggtacg ctattggtcg cgtggcgagc gggtttggcg acctgcggtg     4080

gttttatgtt attatcgcta aagggcaaag gtagtgtcaa gaagaattta ccgtttgtaa     4140

tggccctagg cctcaccgcg gtccgcctag tagaccccat aaatgtcgtc ggcctactat     4200

tattaacgcg cagtggtaag cggtcctggc ccccctccga agtattaacg gcggtaggtc     4260

taatatgcgc gttggcgggc ggtttcgcca aggcggatat agagatggcg ggtcccatgg     4320

ccgcggtagg tctactcatt gtaagttacg tcgtatcggg caagagtgtc gacatgtaca     4380

ttgaacgagc gggtgacata acgtgggaaa aagatgcgga agtaaccggc aatagtcccc     4440

ggttagatgt cgcgctcgat gagagtggtg atttctcgct agtcgaggat gacggtcccc     4500

cgatgcgaga gataatatta aaggtcgtac taatgaccat atgtggtatg aatccgatag     4560

ccataccctt cgcggcgggc gcgtggtacg tatacgtcaa gaccggcaaa cgcagtggtg     4620

cgctctggga tgtccccgcg cccaaggaag taaaaaaggg tgagaccacg gatggcgtct     4680

accgagtaat gacccgtcga ctactcggtt cgacgcaagt aggcgtcggc gtaatgcaag     4740

agggtgtatt ccacaccatg tggcatgtaa cgaaaggctc ggcgctacga tccggtgaag     4800

gtcgattgga tccgtactgg ggcgatgtaa agcaagatct agtctcgtac tgtggtccgt     4860

ggaagctcga tgccgcctgg gacggtcact ccgaggtcca gttattggcc gtcccgccgg     4920

gcgagcgagc gcgcaatata caaactctac ccggcatatt caagacgaag gatggtgaca     4980

ttggcgcggt agcgctagat tacccggcgg gcacttcggg ctcgccgata ctcgacaagt     5040

gtggtcgagt cataggcttg tatggtaatg gtgtagtcat aaaaaatggt agttatgtaa     5100

gtgccataac ccaaggtcgc cgcgaagaag agacccccgt agagtgcttc gagccctcga     5160

tgctaaagaa gaagcaactc actgtattag acttgcatcc cggcgcgggt aaaacccgcc     5220

gagtattgcc cgaaatagta cgtgaagcca taaaaacgcg attacgtacc gtcatattag     5280

cgccgacccg cgtagtagcg gcggaaatgg aggaggcctt gcgaggtttg ccggtccgtt     5340

atatgacgac ggcggtaaat gtaacccatt cgggcacgga aatagtagac ttaatgtgcc     5400

atgccacctt cacctcgcgt ctcctccagc cgatacgagt acccaattat aatctatata     5460

ttatggatga ggcccatttc acggatccct cgagtatagc ggcgcgaggc tacatttcga     5520

cgcgcgtaga gatgggtgag gcggcggcca tattcatgac cgccacgccg ccgggcaccc     5580

gtgacgcgtt cccggactcg aattcgccga ttatggacac cgaagtcgaa gtaccggagc     5640

gagcctggtc ctcgggtttt gattgggtca cggatcattc gggcaaaacg gtatggttcg     5700

taccgtccgt ccgcaatggt aatgagatag cggcgtgtct aacgaaggcg ggcaaacggg     5760

taatacagtt atcccgaaag accttcgaga cggagttcca aaaaacgaaa catcaagagt     5820

gggacttcgt agtcacgacc gacatttcgg agatgggtgc caatttcaaa gcggaccgtg     5880

taatagattc gcgccgatgc ctcaagccgg taatattgga tggtgagcga gtaattctag     5940

cgggccccat gcccgtaacg catgcctccg cggcccaacg ccgcggtcgc ataggtcgca     6000

atcccaataa acccggcgat gagtatctat atggcggtgg ttgcgcggag accgacgaag     6060

accatgcgca ttggttggaa gcgcgaatgt tattggacaa tatttactta caagatggtt     6120

taatagcctc gttatatcga cccgaggccg acaaagtagc ggccattgag ggcgagttca     6180

agttgcgcac ggagcaacgc aagaccttcg tcgaattaat gaaacgaggc gatttgcccg     6240

tatggctagc ctatcaagta gcgtcggcag gtataaccta cacggatcga cgatggtgct     6300

tcgatggtac gaccaataat accataatgg aagatagtgt gccggcagag gtgtggacca     6360

gacacggaga gaaaagagtg ctcaaaccga ggtggatgga cgccagagtt tgttcagatc     6420

atgcggccct gaagtcattc aaggagtttg ccgctgggaa aagaggagcg gcttttggag     6480

tgatggaagc cctgggaaca ctgccaggac acatgacaga gagattccag gaagccattg     6540

acaacctcgc tgtgctcatg cgggcagaga ctggaagcag gccttacaaa gccgcggcgg     6600

cccaattgcc ggagacccta gagaccataa tgcttttggg gttgctggga acagtctcgc     6660

tgggaatctt cttcgtcttg atgaggaaca agggcatagg gaagatgggc tttggaatgg     6720

tgactcttgg ggccagcgca tggctcatgt ggctctcgga aattgagcca gccagaattg     6780

catgtgtcct cattgttgtg ttcctattgc tggtggtgct catacctgag ccagaaaagc     6840

aaagatctcc ccaggacaac caaatggcaa tcatcatcat ggtagcagta ggtcttctgg     6900

gcttgattac cgccaatgaa ctcggatggt tggagagaac aaagagtgac ctaagccatc     6960

taatgggaag gagagaggag ggggcaacca taggattctc aatggacatt gacctgcggc     7020

cagcctcagc ttgggccatc tatgctgcct tgacaacttt cattacccca gccgtccaac     7080

atgcagtgac cacctcatac aacaactact ccttaatggc gatggccacg caagctggag     7140

tgttgtttgg tatgggcaaa gggatgccat tctacgcatg ggactttgga gtcccgctgc     7200

taatgatagg ttgctactca caattaacac ccctgaccct aatagtggcc atcattttgc     7260

tcgtggcgca ctacatgtac ttgatcccag ggctgcaggc agcagctgcg cgtgctgccc     7320

agaagagaac ggcagctggc atcatgaaga accctgttgt ggatggaata gtggtgactg     7380

acattgacac aatgacaatt gacccccaag tggagaaaaa gatgggacag gtgctactca     7440

tagcagtagc cgtctccagc gccatactgt cgcggaccgc ctgggggtgg ggggaggctg     7500

gggccctgat cacagccgca acttccactt tgtgggaagg ctctccgaac aagtactgga     7560

actcctctac agccacttca ctgtgtaaca tttttagggg aagttacttg gctggagctt     7620

ctctaatcta cacagtaaca agaaacgctg gcttggtcaa gagacgtggg ggtggaacag     7680

gagagaccct gggagagaaa tggaaggccc gcttgaacca gatgtcggcc ctggagttct     7740

actcctacaa aaagtcaggc atcaccgagg tgtgcagaga agaggcccgc cgcgccctca     7800

aggacggtgt ggcaacggga ggccatgctg tgtcccgagg aagtgcaaag ctgagatggt     7860

tggtggagcg gggatacctg cagccctatg gaaaggtcat tgatcttgga tgtggcagag     7920

ggggctggag ttactacgcc gccaccatcc gcaaagttca agaagtgaaa ggatacacaa     7980

aaggaggccc tggtcatgaa gaacccgtgt tggtgcaaag ctatgggtgg aacatagtcc     8040

gtcttaagag tggggtggac gtctttcata tggcggctga gccgtgtgac acgctgctgt     8100

gtgacatagg tgagtcatca tctagtcctg aagtggaaga agcacggacg ctcagagtcc     8160

tctccatggt gggggattgg cttgaaaaaa gaccaggagc cttttgtata aaagtgttgt     8220

gcccatacac cagcactatg atggaaaccc tggagcgact gcagcgtagg tatgggggag     8280

gactggtcag agtgccactc tcccgcaact ctacacatga gatgtactgg gtctctggag     8340

cgaaaagcaa caccataaaa agtgtgtcca ccacgagcca gctcctcttg gggcgcatgg     8400

acgggcctag aaggccagtg aaatatgagg aggatgtgaa tctcggctct ggcacgcggg     8460

ctgtggtaag ctgcgctgaa gctcccaaca tgaagatcat tggtaaccgc attgaaagga     8520

tccgcagtga gcacgcggaa acgtggttct ttgacgagaa ccacccatat aggacatggg     8580

cttaccatgg aagctatgag gcccccacac aagggtcagc gtcctctcta ataaacgggg     8640

ttgtcaggct cctgtcaaaa ccctgggatg tggtgactgg agtcacagga atagccatga     8700

ccgacaccac accgtatggt cagcaaagag ttttcaagga aaaagtggac actagggtgc     8760

cagaccccca agaaggcact cgtcaggtta tgagcatggt ctcttcctgg ttgtggaaag     8820

agctaggcaa acacaaacgg ccacgagtct gtaccaaaga agagttcatc aacaaggttc     8880

gtagcaatgc agcattaggg gcaatatttg aagaggaaaa agagtggaag actgcagtgg     8940

aagctgtgaa cgatccaagg ttctgggctc tagtggacaa ggaaagagag caccacctga     9000

gaggagagtg ccagagttgt gtgtataaca tgatgggaaa aagagaaaag aaacaagggg     9060

aatttggaaa ggccaagggc agccgcgcca tctggtatat gtggctaggg gctagatttc     9120

tagagttcga agcccttgga ttcttgaacg aggatcactg gatggggaga gagaactcag     9180

gaggtggtgt tgaagggctg ggattacaaa gactcggata tgtcctagaa gagatgagtc     9240

gtataccagg aggaaggatg tatgcagatg acactgctgg ctgggacacc cgcattagca     9300

ggtttgatct ggagaatgaa gctctaatca ccaaccaaat ggagaaaggg cacagggcct     9360

tggcattggc cataatcaag tacacatacc aaaacaaagt ggtaaaggtc cttagaccag     9420

ctgaaaaagg gaaaacagtt atggacatta tttcgagaca agaccaaagg gggagcggac     9480

aagttgtcac ttacgctctt aacacattta ccaacctagt ggtgcaactc attcggaata     9540

tggaggctga ggaagttcta gagatgcaag acttgtggct gctgcggagg tcagagaaag     9600

tgaccaactg gttgcagagc aacggatggg ataggctcaa acgaatggca gtcagtggag     9660

atgattgcgt tgtgaagcca attgatgata ggtttgcaca tgccctcagg ttcttgaatg     9720

atatgggaaa agttagaaag gacacacaag agtggaaacc ctcaactgga tgggacaact     9780

gggaagaagt tccgttttgc tcccaccact tcaacaagct ccatctcaag gacgggaggt     9840

ccattgtggt tccctgccgc caccaagatg aactgattgg ccgggcccgc gtctctccag     9900

gggcgggatg gagcatccgg gagactgctt gcctagcaaa atcatatgcg cagatgtggc     9960

agctccttta tttccacaga agggacctcc gactgatggc caatgccatt tgttcatctg    10020

tgccagttga ctgggttcca actgggagaa ctacctggtc aatccatgga aagggagaat    10080

ggatgaccac tgaagacatg cttgtggtgt ggaacagagt gtggattgag gagaacgacc    10140

acatggaaga caagacccca gttacgaaat ggacagacat tccctatttg ggaaaaaggg    10200

aagacttgtg gtgtggatct ctcatagggc acagaccgcg caccacctgg gctgagaaca    10260

ttaaaaacac agtcaacatg gtgcgcagga tcataggtga tgaagaaaag tacatggact    10320

acctatccac ccaagttcgc tacttgggtg aagaagggtc tacacctgga gtgctgtaag    10380

caccaatctt aatgttgtca ggcctgctag tcagccacag cttggggaaa gctgtgcagc    10440

ctgtgacccc ccaggagaag ctgggaaacc aagcctatag tcaggccgag aacgccatgg    10500

cacggaagaa gccatgctgc ctgtgagccc ctcagaggat actgagtcaa aaaaccccac    10560

gcgcttggag gcgcaggatg ggaaaagaag gtggcgacct tccccaccct tcaatctggg    10620

gcctgaactg gagatcagct gtggatcccc agaagaggga ctagtggtta gaggagaccc    10680

cccggaaaac gcaaaacagc atattgacgc tgggaaagac cagagactcc atgagtttcc    10740

accacgctgg ccgccaggca cagatcgccg aacttcggcg gccggtgtgg ggaaatccat    10800

ggtttct                                                              10807


