                         SEQUENCE LISTING

<110>  AbRegen Pty Ltd
 
<120>  METHODS AND COMPOSITIONS FOR THE TREATMENT OF MUCOSAL LESIONS

<130>  1155717

<140>  2018903891
<141>  2018-10-15

<160>  25    

<170>  PatentIn version 3.5

<210>  1
<211>  4387
<212>  DNA
<213>  Homo sapiens

<400>  1
aactccagca cagggggggc ccgcactcct tggtgcctcc gcagtcttcg aacagacggg       60

gaaactgagg ccctaagagg cctaaagcct acacttcccc gcggaatgcg gcgggcgcgg      120

gcgggttaaa ggggcggggc cggcgctggc ccagcccgcg gctcccccca gcgccctcgc      180

cccggcgctc cctagcccgg cgcggcccgg cagcgagagc ggcgccatgg aggccaccgg      240

ggtgctgccg ttcgtgcgtg gcgtggacct cagcggcaac gacttcaagg gcggctactt      300

ccctgagaat gtcaaggcca tgaccagcct gcggtggctg aagctgaacc gcactggcct      360

ctgctacctg cccgaggagc tggccgccct gcagaagctg gaacacttgt ctgtgagcca      420

caacaacctg accacgcttc atggggagct gtccagcctg ccatcgctgc gcgccatcgt      480

ggcccgagcc aacagtctga agaattccgg agtccccgat gacatcttca agctagatga      540

tctctcagtc ctggacttga gccacaacca gctgacagag tgcccgcggg agctggagaa      600

cgccaagaac atgctggtgc tgaacctcag ccacaacagc atcgacacca tccccaacca      660

gctcttcatc aacctcactg acctactata cctggacctc agcgagaacc gcctggagag      720

cctgcccccg cagatgcgcc gcctggtgca cctgcagacg ctcgtgctca atggaaaccc      780

cctgctgcat gcacagctcc ggcagctccc agcgatgacg gccctgcaga ccctgcacct      840

gcggagcacc cagcgcaccc agagcaacct gcccaccagc ctggagggtc tgagcaacct      900

cgcagacgtg gatctgtcct gcaatgacct gacacgggtg cccgagtgtc tgtacaccct      960

ccccagcctg cgccgcctca acctcagcag caaccagatc acggagctgt ccctgtgcat     1020

agaccagtgg gtgcacgtgg aaactctgaa cctgtcccga aatcagctca cctcactgcc     1080

ctcagccatt tgcaagctga gcaagctgaa gaagctgtac ctgaattcca acaagctgga     1140

ctttgacggg ctgccctcag gcattggcaa gctcaccaac ctggaagagt tcatggctgc     1200

caacaacaac ctggagctgg tccctgaaag tctctgcagg tgcccaaagc tgaggaaact     1260

tgtcctgaac aagaaccacc tggtgaccct cccagaagcc atccatttcc tgacggagat     1320

cgaggtcctg gatgtgcggg agaaccccaa cctggtcatg ccgcccaagc ccgcagaccg     1380

tgccgctgag tggtacaaca tcgacttctc gctgcagaac cagctgcggc tagcgggtgc     1440

ctctcctgct accgtggctg cagctgcagc tgcagggagt gggcccaagg accctatggc     1500

tcgcaagatg cgactgcgga ggcgcaagga ttcagcccag gatgaccagg ccaagcaggt     1560

gctgaagggc atgtcagatg ttgcccagga gaagaacaaa aagcaggagg agagcgcaga     1620

tgcccgggcc cccagcggga aggtgcggcg ttgggaccag ggcctggaga agccccgcct     1680

tgactactcc gagttcttca cggaggacgt gggccagctg cccggactga ccatctggca     1740

gatagagaac ttcgtgcctg tgctggtgga ggaagccttc cacggcaagt tctacgaggc     1800

tgactgctac attgtgctca agacctttct ggatgacagc ggctccctca actgggagat     1860

ctactactgg attggcgggg aggccacact cgacaagaaa gcttgctctg ccatccacgc     1920

tgtcaacttg cgcaactacc tgggtgctga gtgccgcact gtccgggagg agatgggcga     1980

tgagagcgag gagttcctgc aggtgtttga caacgacatc tcctacattg agggtggaac     2040

agccagtggc ttctacactg tggaagacac acactatgtc accaggatgt atcgtgtgta     2100

tgggaaaaag aacatcaagt tggagcctgt gcccctcaag gggacctctc tggacccaag     2160

gtttgttttc ctgctggacc gagggctaga catctacgta tggcgggggg cccaggccac     2220

actgagcagc accaccaagg ccaggctctt tgcagagaaa attaacaaga atgagcggaa     2280

agggaaggct gagatcacac tgctggtgca gggccaggag ctcccagagt tctgggaggc     2340

actgggtggg gagccctctg agatcaagaa gcacgtgcct gaagacttct ggccgccgca     2400

gcccaagctg tacaaggtgg gcctgggctt gggctacctg gagctgccac agatcaacta     2460

caagctctcc gtggaacata agcagcgtcc caaggtggag ctgatgccaa gaatgcggct     2520

gctgcagagt ctgctggaca cgcgctgcgt gtacattctg gactgttggt ccgacgtgtt     2580

catctggctc ggccgcaagt ccccgcgcct ggtgcgcgct gccgccctca agctgggtca     2640

ggagctgtgc gggatgctgc accggccacg ccatgccacg gtcagccgca gcctcgaggg     2700

caccgaggcg caggtgttca aggccaagtt caagaattgg gacgatgtgt tgacggtgga     2760

ctacacacgc aatgcggagg ccgtgctgca gagcccgggt ctctccggga aggtgaaacg     2820

cgacgccgag aagaaagacc agatgaaggc tgacctcact gcgcttttcc tgccgcggca     2880

gccgcccatg tcgctggccg aggcggagca gctgatggag gagtggaacg aagacctaga     2940

cggcatggag ggtttcgtgc tggagggcaa gaagtttgcg cggctgccgg aagaggagtt     3000

tggccacttc tacacgcagg actgctacgt cttcctctgc aggtactggg tgcctgtgga     3060

gtacgaggag gaggaaaaga aggaagacaa ggaggagaag gccgagggca aagaaggcga     3120

ggaagcaacc gctgaggcag aggagaagca gccagaggag gacttccagt gcatcgtgta     3180

cttctggcag ggccgtgaag cctccaatat gggctggctc accttcacct tcagcctgca     3240

aaagaagttc gagagcctct tccctgggaa gctggaggtg gtacgcatga cgcagcagca     3300

ggagaacccc aagttcctgt cccatttcaa gaggaagttc atcatccacc ggggcaagag     3360

gaaggcggtc cagggcgccc aacagcccag cctctaccag atccgcacca acggcagcgc     3420

cctctgcacc cggtgcatcc agatcaacac cgactccagc ctcctcaact ccgagttctg     3480

cttcatcctc aaggttccct ttgagagtga ggacaaccag ggcatcgtgt atgcctgggt     3540

gggccgggca tcagaccctg acgaagccaa gttggcagaa gacatcctga acaccatgtt     3600

tgacacctcc tacagcaagc aggttatcaa cgaaggtgag gagcctgaga acttcttctg     3660

ggtgggcatt ggggcacaga agccctatga tgacgatgcc gagtacatga aacacacacg     3720

tctcttccgg tgctccaacg agaagggcta ctttgcagtg actgagaaat gctccgactt     3780

ttgccaagat gacctggcag atgatgacat catgttgcta gacaatggcc aagaggtcta     3840

catgtgggtg gggacccaga ctagccaggt ggagatcaag ctgagcctga aggcctgcca     3900

ggtatatatc cagcacatgc ggtccaagga acatgagcgg ccgcgccggc tgcgcctggt     3960

ccgcaagggc aatgagcagc acgcctttac ccgctgcttc cacgcctgga gcgccttctg     4020

caaggccctg gcctaagaca ggctggcaca gccccaggct tggtgaggaa gaggaagggg     4080

cctcatccac tgtctgctag caaagaatgt actcaggtga caccacctgc tccagccacg     4140

tccagtgcca cagtccccag tagcctcaag cagcaccaat ggggatgacc ctgacaggtg     4200

ccctcagggg tctgggaaat ccaactctct ccacagtgtg agtgcacgtg tgaagccccc     4260

tcactcttcc gctagggata aagcagatgt ggatgccctt taagagatat taaatgcttt     4320

tattttcaat attaaaaatc agtattttta atattaaaaa aaaaaaaaaa aaaaaaaaaa     4380

aaaaaaa                                                               4387


<210>  2
<211>  1269
<212>  PRT
<213>  Homo sapiens

<400>  2

Met Glu Ala Thr Gly Val Leu Pro Phe Val Arg Gly Val Asp Leu Ser 
1               5                   10                  15      


Gly Asn Asp Phe Lys Gly Gly Tyr Phe Pro Glu Asn Val Lys Ala Met 
            20                  25                  30          


Thr Ser Leu Arg Trp Leu Lys Leu Asn Arg Thr Gly Leu Cys Tyr Leu 
        35                  40                  45              


Pro Glu Glu Leu Ala Ala Leu Gln Lys Leu Glu His Leu Ser Val Ser 
    50                  55                  60                  


His Asn Asn Leu Thr Thr Leu His Gly Glu Leu Ser Ser Leu Pro Ser 
65                  70                  75                  80  


Leu Arg Ala Ile Val Ala Arg Ala Asn Ser Leu Lys Asn Ser Gly Val 
                85                  90                  95      


Pro Asp Asp Ile Phe Lys Leu Asp Asp Leu Ser Val Leu Asp Leu Ser 
            100                 105                 110         


His Asn Gln Leu Thr Glu Cys Pro Arg Glu Leu Glu Asn Ala Lys Asn 
        115                 120                 125             


Met Leu Val Leu Asn Leu Ser His Asn Ser Ile Asp Thr Ile Pro Asn 
    130                 135                 140                 


Gln Leu Phe Ile Asn Leu Thr Asp Leu Leu Tyr Leu Asp Leu Ser Glu 
145                 150                 155                 160 


Asn Arg Leu Glu Ser Leu Pro Pro Gln Met Arg Arg Leu Val His Leu 
                165                 170                 175     


Gln Thr Leu Val Leu Asn Gly Asn Pro Leu Leu His Ala Gln Leu Arg 
            180                 185                 190         


Gln Leu Pro Ala Met Thr Ala Leu Gln Thr Leu His Leu Arg Ser Thr 
        195                 200                 205             


Gln Arg Thr Gln Ser Asn Leu Pro Thr Ser Leu Glu Gly Leu Ser Asn 
    210                 215                 220                 


Leu Ala Asp Val Asp Leu Ser Cys Asn Asp Leu Thr Arg Val Pro Glu 
225                 230                 235                 240 


Cys Leu Tyr Thr Leu Pro Ser Leu Arg Arg Leu Asn Leu Ser Ser Asn 
                245                 250                 255     


Gln Ile Thr Glu Leu Ser Leu Cys Ile Asp Gln Trp Val His Val Glu 
            260                 265                 270         


Thr Leu Asn Leu Ser Arg Asn Gln Leu Thr Ser Leu Pro Ser Ala Ile 
        275                 280                 285             


Cys Lys Leu Ser Lys Leu Lys Lys Leu Tyr Leu Asn Ser Asn Lys Leu 
    290                 295                 300                 


Asp Phe Asp Gly Leu Pro Ser Gly Ile Gly Lys Leu Thr Asn Leu Glu 
305                 310                 315                 320 


Glu Phe Met Ala Ala Asn Asn Asn Leu Glu Leu Val Pro Glu Ser Leu 
                325                 330                 335     


Cys Arg Cys Pro Lys Leu Arg Lys Leu Val Leu Asn Lys Asn His Leu 
            340                 345                 350         


Val Thr Leu Pro Glu Ala Ile His Phe Leu Thr Glu Ile Glu Val Leu 
        355                 360                 365             


Asp Val Arg Glu Asn Pro Asn Leu Val Met Pro Pro Lys Pro Ala Asp 
    370                 375                 380                 


Arg Ala Ala Glu Trp Tyr Asn Ile Asp Phe Ser Leu Gln Asn Gln Leu 
385                 390                 395                 400 


Arg Leu Ala Gly Ala Ser Pro Ala Thr Val Ala Ala Ala Ala Ala Ala 
                405                 410                 415     


Gly Ser Gly Pro Lys Asp Pro Met Ala Arg Lys Met Arg Leu Arg Arg 
            420                 425                 430         


Arg Lys Asp Ser Ala Gln Asp Asp Gln Ala Lys Gln Val Leu Lys Gly 
        435                 440                 445             


Met Ser Asp Val Ala Gln Glu Lys Asn Lys Lys Gln Glu Glu Ser Ala 
    450                 455                 460                 


Asp Ala Arg Ala Pro Ser Gly Lys Val Arg Arg Trp Asp Gln Gly Leu 
465                 470                 475                 480 


Glu Lys Pro Arg Leu Asp Tyr Ser Glu Phe Phe Thr Glu Asp Val Gly 
                485                 490                 495     


Gln Leu Pro Gly Leu Thr Ile Trp Gln Ile Glu Asn Phe Val Pro Val 
            500                 505                 510         


Leu Val Glu Glu Ala Phe His Gly Lys Phe Tyr Glu Ala Asp Cys Tyr 
        515                 520                 525             


Ile Val Leu Lys Thr Phe Leu Asp Asp Ser Gly Ser Leu Asn Trp Glu 
    530                 535                 540                 


Ile Tyr Tyr Trp Ile Gly Gly Glu Ala Thr Leu Asp Lys Lys Ala Cys 
545                 550                 555                 560 


Ser Ala Ile His Ala Val Asn Leu Arg Asn Tyr Leu Gly Ala Glu Cys 
                565                 570                 575     


Arg Thr Val Arg Glu Glu Met Gly Asp Glu Ser Glu Glu Phe Leu Gln 
            580                 585                 590         


Val Phe Asp Asn Asp Ile Ser Tyr Ile Glu Gly Gly Thr Ala Ser Gly 
        595                 600                 605             


Phe Tyr Thr Val Glu Asp Thr His Tyr Val Thr Arg Met Tyr Arg Val 
    610                 615                 620                 


Tyr Gly Lys Lys Asn Ile Lys Leu Glu Pro Val Pro Leu Lys Gly Thr 
625                 630                 635                 640 


Ser Leu Asp Pro Arg Phe Val Phe Leu Leu Asp Arg Gly Leu Asp Ile 
                645                 650                 655     


Tyr Val Trp Arg Gly Ala Gln Ala Thr Leu Ser Ser Thr Thr Lys Ala 
            660                 665                 670         


Arg Leu Phe Ala Glu Lys Ile Asn Lys Asn Glu Arg Lys Gly Lys Ala 
        675                 680                 685             


Glu Ile Thr Leu Leu Val Gln Gly Gln Glu Leu Pro Glu Phe Trp Glu 
    690                 695                 700                 


Ala Leu Gly Gly Glu Pro Ser Glu Ile Lys Lys His Val Pro Glu Asp 
705                 710                 715                 720 


Phe Trp Pro Pro Gln Pro Lys Leu Tyr Lys Val Gly Leu Gly Leu Gly 
                725                 730                 735     


Tyr Leu Glu Leu Pro Gln Ile Asn Tyr Lys Leu Ser Val Glu His Lys 
            740                 745                 750         


Gln Arg Pro Lys Val Glu Leu Met Pro Arg Met Arg Leu Leu Gln Ser 
        755                 760                 765             


Leu Leu Asp Thr Arg Cys Val Tyr Ile Leu Asp Cys Trp Ser Asp Val 
    770                 775                 780                 


Phe Ile Trp Leu Gly Arg Lys Ser Pro Arg Leu Val Arg Ala Ala Ala 
785                 790                 795                 800 


Leu Lys Leu Gly Gln Glu Leu Cys Gly Met Leu His Arg Pro Arg His 
                805                 810                 815     


Ala Thr Val Ser Arg Ser Leu Glu Gly Thr Glu Ala Gln Val Phe Lys 
            820                 825                 830         


Ala Lys Phe Lys Asn Trp Asp Asp Val Leu Thr Val Asp Tyr Thr Arg 
        835                 840                 845             


Asn Ala Glu Ala Val Leu Gln Ser Pro Gly Leu Ser Gly Lys Val Lys 
    850                 855                 860                 


Arg Asp Ala Glu Lys Lys Asp Gln Met Lys Ala Asp Leu Thr Ala Leu 
865                 870                 875                 880 


Phe Leu Pro Arg Gln Pro Pro Met Ser Leu Ala Glu Ala Glu Gln Leu 
                885                 890                 895     


Met Glu Glu Trp Asn Glu Asp Leu Asp Gly Met Glu Gly Phe Val Leu 
            900                 905                 910         


Glu Gly Lys Lys Phe Ala Arg Leu Pro Glu Glu Glu Phe Gly His Phe 
        915                 920                 925             


Tyr Thr Gln Asp Cys Tyr Val Phe Leu Cys Arg Tyr Trp Val Pro Val 
    930                 935                 940                 


Glu Tyr Glu Glu Glu Glu Lys Lys Glu Asp Lys Glu Glu Lys Ala Glu 
945                 950                 955                 960 


Gly Lys Glu Gly Glu Glu Ala Thr Ala Glu Ala Glu Glu Lys Gln Pro 
                965                 970                 975     


Glu Glu Asp Phe Gln Cys Ile Val Tyr Phe Trp Gln Gly Arg Glu Ala 
            980                 985                 990         


Ser Asn Met Gly Trp Leu Thr Phe  Thr Phe Ser Leu Gln  Lys Lys Phe 
        995                 1000                 1005             


Glu Ser  Leu Phe Pro Gly Lys  Leu Glu Val Val Arg  Met Thr Gln 
    1010                 1015                 1020             


Gln Gln  Glu Asn Pro Lys Phe  Leu Ser His Phe Lys  Arg Lys Phe 
    1025                 1030                 1035             


Ile Ile  His Arg Gly Lys Arg  Lys Ala Val Gln Gly  Ala Gln Gln 
    1040                 1045                 1050             


Pro Ser  Leu Tyr Gln Ile Arg  Thr Asn Gly Ser Ala  Leu Cys Thr 
    1055                 1060                 1065             


Arg Cys  Ile Gln Ile Asn Thr  Asp Ser Ser Leu Leu  Asn Ser Glu 
    1070                 1075                 1080             


Phe Cys  Phe Ile Leu Lys Val  Pro Phe Glu Ser Glu  Asp Asn Gln 
    1085                 1090                 1095             


Gly Ile  Val Tyr Ala Trp Val  Gly Arg Ala Ser Asp  Pro Asp Glu 
    1100                 1105                 1110             


Ala Lys  Leu Ala Glu Asp Ile  Leu Asn Thr Met Phe  Asp Thr Ser 
    1115                 1120                 1125             


Tyr Ser  Lys Gln Val Ile Asn  Glu Gly Glu Glu Pro  Glu Asn Phe 
    1130                 1135                 1140             


Phe Trp  Val Gly Ile Gly Ala  Gln Lys Pro Tyr Asp  Asp Asp Ala 
    1145                 1150                 1155             


Glu Tyr  Met Lys His Thr Arg  Leu Phe Arg Cys Ser  Asn Glu Lys 
    1160                 1165                 1170             


Gly Tyr  Phe Ala Val Thr Glu  Lys Cys Ser Asp Phe  Cys Gln Asp 
    1175                 1180                 1185             


Asp Leu  Ala Asp Asp Asp Ile  Met Leu Leu Asp Asn  Gly Gln Glu 
    1190                 1195                 1200             


Val Tyr  Met Trp Val Gly Thr  Gln Thr Ser Gln Val  Glu Ile Lys 
    1205                 1210                 1215             


Leu Ser  Leu Lys Ala Cys Gln  Val Tyr Ile Gln His  Met Arg Ser 
    1220                 1225                 1230             


Lys Glu  His Glu Arg Pro Arg  Arg Leu Arg Leu Val  Arg Lys Gly 
    1235                 1240                 1245             


Asn Glu  Gln His Ala Phe Thr  Arg Cys Phe His Ala  Trp Ser Ala 
    1250                 1255                 1260             


Phe Cys  Lys Ala Leu Ala 
    1265                 


<210>  3
<211>  4208
<212>  DNA
<213>  Homo sapiens

<400>  3
ttcctgtccc gctcggctcc aggccctgcg tgtcccaggg actgcggccg gggcggggtg       60

gggctctccc ctggccagga atggacctcc gaggcctccg cccagtgcct ggcggctact      120

tccctgagaa tgtcaaggcc atgaccagcc tgcggtggct gaagctgaac cgcactggcc      180

tctgctacct gcccgaggag ctggccgccc tgcagaagct ggaacacttg tctgtgagcc      240

acaacaacct gaccacgctt catggggagc tgtccagcct gccatcgctg cgcgccatcg      300

tggcccgagc caacagtctg aagaattccg gagtccccga tgacatcttc aagctagatg      360

atctctcagt cctggacttg agccacaacc agctgacaga gtgcccgcgg gagctggaga      420

acgccaagaa catgctggtg ctgaacctca gccacaacag catcgacacc atccccaacc      480

agctcttcat caacctcact gacctactat acctggacct cagcgagaac cgcctggaga      540

gcctgccccc gcagatgcgc cgcctggtgc acctgcagac gctcgtgctc aatggaaacc      600

ccctgctgca tgcacagctc cggcagctcc cagcgatgac ggccctgcag accctgcacc      660

tgcggagcac ccagcgcacc cagagcaacc tgcccaccag cctggagggt ctgagcaacc      720

tcgcagacgt ggatctgtcc tgcaatgacc tgacacgggt gcccgagtgt ctgtacaccc      780

tccccagcct gcgccgcctc aacctcagca gcaaccagat cacggagctg tccctgtgca      840

tagaccagtg ggtgcacgtg gaaactctga acctgtcccg aaatcagctc acctcactgc      900

cctcagccat ttgcaagctg agcaagctga agaagctgta cctgaattcc aacaagctgg      960

actttgacgg gctgccctca ggcattggca agctcaccaa cctggaagag ttcatggctg     1020

ccaacaacaa cctggagctg gtccctgaaa gtctctgcag gtgcccaaag ctgaggaaac     1080

ttgtcctgaa caagaaccac ctggtgaccc tcccagaagc catccatttc ctgacggaga     1140

tcgaggtcct ggatgtgcgg gagaacccca acctggtcat gccgcccaag cccgcagacc     1200

gtgccgctga gtggtacaac atcgacttct cgctgcagaa ccagctgcgg ctagcgggtg     1260

cctctcctgc taccgtggct gcagctgcag ctgcagggag tgggcccaag gaccctatgg     1320

ctcgcaagat gcgactgcgg aggcgcaagg attcagccca ggatgaccag gccaagcagg     1380

tgctgaaggg catgtcagat gttgcccagg agaagaacaa aaagcaggag gagagcgcag     1440

atgcccgggc ccccagcggg aaggtgcggc gttgggacca gggcctggag aagccccgcc     1500

ttgactactc cgagttcttc acggaggacg tgggccagct gcccggactg accatctggc     1560

agatagagaa cttcgtgcct gtgctggtgg aggaagcctt ccacggcaag ttctacgagg     1620

ctgactgcta cattgtgctc aagacctttc tggatgacag cggctccctc aactgggaga     1680

tctactactg gattggcggg gaggccacac tcgacaagaa agcttgctct gccatccacg     1740

ctgtcaactt gcgcaactac ctgggtgctg agtgccgcac tgtccgggag gagatgggcg     1800

atgagagcga ggagttcctg caggtgtttg acaacgacat ctcctacatt gagggtggaa     1860

cagccagtgg cttctacact gtggaagaca cacactatgt caccaggatg tatcgtgtgt     1920

atgggaaaaa gaacatcaag ttggagcctg tgcccctcaa ggggacctct ctggacccaa     1980

ggtttgtttt cctgctggac cgagggctag acatctacgt atggcggggg gcccaggcca     2040

cactgagcag caccaccaag gccaggctct ttgcagagaa aattaacaag aatgagcgga     2100

aagggaaggc tgagatcaca ctgctggtgc agggccagga gctcccagag ttctgggagg     2160

cactgggtgg ggagccctct gagatcaaga agcacgtgcc tgaagacttc tggccgccgc     2220

agcccaagct gtacaaggtg ggcctgggct tgggctacct ggagctgcca cagatcaact     2280

acaagctctc cgtggaacat aagcagcgtc ccaaggtgga gctgatgcca agaatgcggc     2340

tgctgcagag tctgctggac acgcgctgcg tgtacattct ggactgttgg tccgacgtgt     2400

tcatctggct cggccgcaag tccccgcgcc tggtgcgcgc tgccgccctc aagctgggtc     2460

aggagctgtg cgggatgctg caccggccac gccatgccac ggtcagccgc agcctcgagg     2520

gcaccgaggc gcaggtgttc aaggccaagt tcaagaattg ggacgatgtg ttgacggtgg     2580

actacacacg caatgcggag gccgtgctgc agagcccggg tctctccggg aaggtgaaac     2640

gcgacgccga gaagaaagac cagatgaagg ctgacctcac tgcgcttttc ctgccgcggc     2700

agccgcccat gtcgctggcc gaggcggagc agctgatgga ggagtggaac gaagacctag     2760

acggcatgga gggtttcgtg ctggagggca agaagtttgc gcggctgccg gaagaggagt     2820

ttggccactt ctacacgcag gactgctacg tcttcctctg caggtactgg gtgcctgtgg     2880

agtacgagga ggaggaaaag aaggaagaca aggaggagaa ggccgagggc aaagaaggcg     2940

aggaagcaac cgctgaggca gaggagaagc agccagagga ggacttccag tgcatcgtgt     3000

acttctggca gggccgtgaa gcctccaata tgggctggct caccttcacc ttcagcctgc     3060

aaaagaagtt cgagagcctc ttccctggga agctggaggt ggtacgcatg acgcagcagc     3120

aggagaaccc caagttcctg tcccatttca agaggaagtt catcatccac cggggcaaga     3180

ggaaggcggt ccagggcgcc caacagccca gcctctacca gatccgcacc aacggcagcg     3240

ccctctgcac ccggtgcatc cagatcaaca ccgactccag cctcctcaac tccgagttct     3300

gcttcatcct caaggttccc tttgagagtg aggacaacca gggcatcgtg tatgcctggg     3360

tgggccgggc atcagaccct gacgaagcca agttggcaga agacatcctg aacaccatgt     3420

ttgacacctc ctacagcaag caggttatca acgaaggtga ggagcctgag aacttcttct     3480

gggtgggcat tggggcacag aagccctatg atgacgatgc cgagtacatg aaacacacac     3540

gtctcttccg gtgctccaac gagaagggct actttgcagt gactgagaaa tgctccgact     3600

tttgccaaga tgacctggca gatgatgaca tcatgttgct agacaatggc caagaggtct     3660

acatgtgggt ggggacccag actagccagg tggagatcaa gctgagcctg aaggcctgcc     3720

aggtatatat ccagcacatg cggtccaagg aacatgagcg gccgcgccgg ctgcgcctgg     3780

tccgcaaggg caatgagcag cacgccttta cccgctgctt ccacgcctgg agcgccttct     3840

gcaaggccct ggcctaagac aggctggcac agccccaggc ttggtgagga agaggaaggg     3900

gcctcatcca ctgtctgcta gcaaagaatg tactcaggtg acaccacctg ctccagccac     3960

gtccagtgcc acagtcccca gtagcctcaa gcagcaccaa tggggatgac cctgacaggt     4020

gccctcaggg gtctgggaaa tccaactctc tccacagtgt gagtgcacgt gtgaagcccc     4080

ctcactcttc cgctagggat aaagcagatg tggatgccct ttaagagata ttaaatgctt     4140

ttattttcaa tattaaaaat cagtattttt aatattaaaa aaaaaaaaaa aaaaaaaaaa     4200

aaaaaaaa                                                              4208


<210>  4
<211>  1258
<212>  PRT
<213>  Homo sapiens

<400>  4

Met Asp Leu Arg Gly Leu Arg Pro Val Pro Gly Gly Tyr Phe Pro Glu 
1               5                   10                  15      


Asn Val Lys Ala Met Thr Ser Leu Arg Trp Leu Lys Leu Asn Arg Thr 
            20                  25                  30          


Gly Leu Cys Tyr Leu Pro Glu Glu Leu Ala Ala Leu Gln Lys Leu Glu 
        35                  40                  45              


His Leu Ser Val Ser His Asn Asn Leu Thr Thr Leu His Gly Glu Leu 
    50                  55                  60                  


Ser Ser Leu Pro Ser Leu Arg Ala Ile Val Ala Arg Ala Asn Ser Leu 
65                  70                  75                  80  


Lys Asn Ser Gly Val Pro Asp Asp Ile Phe Lys Leu Asp Asp Leu Ser 
                85                  90                  95      


Val Leu Asp Leu Ser His Asn Gln Leu Thr Glu Cys Pro Arg Glu Leu 
            100                 105                 110         


Glu Asn Ala Lys Asn Met Leu Val Leu Asn Leu Ser His Asn Ser Ile 
        115                 120                 125             


Asp Thr Ile Pro Asn Gln Leu Phe Ile Asn Leu Thr Asp Leu Leu Tyr 
    130                 135                 140                 


Leu Asp Leu Ser Glu Asn Arg Leu Glu Ser Leu Pro Pro Gln Met Arg 
145                 150                 155                 160 


Arg Leu Val His Leu Gln Thr Leu Val Leu Asn Gly Asn Pro Leu Leu 
                165                 170                 175     


His Ala Gln Leu Arg Gln Leu Pro Ala Met Thr Ala Leu Gln Thr Leu 
            180                 185                 190         


His Leu Arg Ser Thr Gln Arg Thr Gln Ser Asn Leu Pro Thr Ser Leu 
        195                 200                 205             


Glu Gly Leu Ser Asn Leu Ala Asp Val Asp Leu Ser Cys Asn Asp Leu 
    210                 215                 220                 


Thr Arg Val Pro Glu Cys Leu Tyr Thr Leu Pro Ser Leu Arg Arg Leu 
225                 230                 235                 240 


Asn Leu Ser Ser Asn Gln Ile Thr Glu Leu Ser Leu Cys Ile Asp Gln 
                245                 250                 255     


Trp Val His Val Glu Thr Leu Asn Leu Ser Arg Asn Gln Leu Thr Ser 
            260                 265                 270         


Leu Pro Ser Ala Ile Cys Lys Leu Ser Lys Leu Lys Lys Leu Tyr Leu 
        275                 280                 285             


Asn Ser Asn Lys Leu Asp Phe Asp Gly Leu Pro Ser Gly Ile Gly Lys 
    290                 295                 300                 


Leu Thr Asn Leu Glu Glu Phe Met Ala Ala Asn Asn Asn Leu Glu Leu 
305                 310                 315                 320 


Val Pro Glu Ser Leu Cys Arg Cys Pro Lys Leu Arg Lys Leu Val Leu 
                325                 330                 335     


Asn Lys Asn His Leu Val Thr Leu Pro Glu Ala Ile His Phe Leu Thr 
            340                 345                 350         


Glu Ile Glu Val Leu Asp Val Arg Glu Asn Pro Asn Leu Val Met Pro 
        355                 360                 365             


Pro Lys Pro Ala Asp Arg Ala Ala Glu Trp Tyr Asn Ile Asp Phe Ser 
    370                 375                 380                 


Leu Gln Asn Gln Leu Arg Leu Ala Gly Ala Ser Pro Ala Thr Val Ala 
385                 390                 395                 400 


Ala Ala Ala Ala Ala Gly Ser Gly Pro Lys Asp Pro Met Ala Arg Lys 
                405                 410                 415     


Met Arg Leu Arg Arg Arg Lys Asp Ser Ala Gln Asp Asp Gln Ala Lys 
            420                 425                 430         


Gln Val Leu Lys Gly Met Ser Asp Val Ala Gln Glu Lys Asn Lys Lys 
        435                 440                 445             


Gln Glu Glu Ser Ala Asp Ala Arg Ala Pro Ser Gly Lys Val Arg Arg 
    450                 455                 460                 


Trp Asp Gln Gly Leu Glu Lys Pro Arg Leu Asp Tyr Ser Glu Phe Phe 
465                 470                 475                 480 


Thr Glu Asp Val Gly Gln Leu Pro Gly Leu Thr Ile Trp Gln Ile Glu 
                485                 490                 495     


Asn Phe Val Pro Val Leu Val Glu Glu Ala Phe His Gly Lys Phe Tyr 
            500                 505                 510         


Glu Ala Asp Cys Tyr Ile Val Leu Lys Thr Phe Leu Asp Asp Ser Gly 
        515                 520                 525             


Ser Leu Asn Trp Glu Ile Tyr Tyr Trp Ile Gly Gly Glu Ala Thr Leu 
    530                 535                 540                 


Asp Lys Lys Ala Cys Ser Ala Ile His Ala Val Asn Leu Arg Asn Tyr 
545                 550                 555                 560 


Leu Gly Ala Glu Cys Arg Thr Val Arg Glu Glu Met Gly Asp Glu Ser 
                565                 570                 575     


Glu Glu Phe Leu Gln Val Phe Asp Asn Asp Ile Ser Tyr Ile Glu Gly 
            580                 585                 590         


Gly Thr Ala Ser Gly Phe Tyr Thr Val Glu Asp Thr His Tyr Val Thr 
        595                 600                 605             


Arg Met Tyr Arg Val Tyr Gly Lys Lys Asn Ile Lys Leu Glu Pro Val 
    610                 615                 620                 


Pro Leu Lys Gly Thr Ser Leu Asp Pro Arg Phe Val Phe Leu Leu Asp 
625                 630                 635                 640 


Arg Gly Leu Asp Ile Tyr Val Trp Arg Gly Ala Gln Ala Thr Leu Ser 
                645                 650                 655     


Ser Thr Thr Lys Ala Arg Leu Phe Ala Glu Lys Ile Asn Lys Asn Glu 
            660                 665                 670         


Arg Lys Gly Lys Ala Glu Ile Thr Leu Leu Val Gln Gly Gln Glu Leu 
        675                 680                 685             


Pro Glu Phe Trp Glu Ala Leu Gly Gly Glu Pro Ser Glu Ile Lys Lys 
    690                 695                 700                 


His Val Pro Glu Asp Phe Trp Pro Pro Gln Pro Lys Leu Tyr Lys Val 
705                 710                 715                 720 


Gly Leu Gly Leu Gly Tyr Leu Glu Leu Pro Gln Ile Asn Tyr Lys Leu 
                725                 730                 735     


Ser Val Glu His Lys Gln Arg Pro Lys Val Glu Leu Met Pro Arg Met 
            740                 745                 750         


Arg Leu Leu Gln Ser Leu Leu Asp Thr Arg Cys Val Tyr Ile Leu Asp 
        755                 760                 765             


Cys Trp Ser Asp Val Phe Ile Trp Leu Gly Arg Lys Ser Pro Arg Leu 
    770                 775                 780                 


Val Arg Ala Ala Ala Leu Lys Leu Gly Gln Glu Leu Cys Gly Met Leu 
785                 790                 795                 800 


His Arg Pro Arg His Ala Thr Val Ser Arg Ser Leu Glu Gly Thr Glu 
                805                 810                 815     


Ala Gln Val Phe Lys Ala Lys Phe Lys Asn Trp Asp Asp Val Leu Thr 
            820                 825                 830         


Val Asp Tyr Thr Arg Asn Ala Glu Ala Val Leu Gln Ser Pro Gly Leu 
        835                 840                 845             


Ser Gly Lys Val Lys Arg Asp Ala Glu Lys Lys Asp Gln Met Lys Ala 
    850                 855                 860                 


Asp Leu Thr Ala Leu Phe Leu Pro Arg Gln Pro Pro Met Ser Leu Ala 
865                 870                 875                 880 


Glu Ala Glu Gln Leu Met Glu Glu Trp Asn Glu Asp Leu Asp Gly Met 
                885                 890                 895     


Glu Gly Phe Val Leu Glu Gly Lys Lys Phe Ala Arg Leu Pro Glu Glu 
            900                 905                 910         


Glu Phe Gly His Phe Tyr Thr Gln Asp Cys Tyr Val Phe Leu Cys Arg 
        915                 920                 925             


Tyr Trp Val Pro Val Glu Tyr Glu Glu Glu Glu Lys Lys Glu Asp Lys 
    930                 935                 940                 


Glu Glu Lys Ala Glu Gly Lys Glu Gly Glu Glu Ala Thr Ala Glu Ala 
945                 950                 955                 960 


Glu Glu Lys Gln Pro Glu Glu Asp Phe Gln Cys Ile Val Tyr Phe Trp 
                965                 970                 975     


Gln Gly Arg Glu Ala Ser Asn Met Gly Trp Leu Thr Phe Thr Phe Ser 
            980                 985                 990         


Leu Gln Lys Lys Phe Glu Ser Leu  Phe Pro Gly Lys Leu  Glu Val Val 
        995                 1000                 1005             


Arg Met  Thr Gln Gln Gln Glu  Asn Pro Lys Phe Leu  Ser His Phe 
    1010                 1015                 1020             


Lys Arg  Lys Phe Ile Ile His  Arg Gly Lys Arg Lys  Ala Val Gln 
    1025                 1030                 1035             


Gly Ala  Gln Gln Pro Ser Leu  Tyr Gln Ile Arg Thr  Asn Gly Ser 
    1040                 1045                 1050             


Ala Leu  Cys Thr Arg Cys Ile  Gln Ile Asn Thr Asp  Ser Ser Leu 
    1055                 1060                 1065             


Leu Asn  Ser Glu Phe Cys Phe  Ile Leu Lys Val Pro  Phe Glu Ser 
    1070                 1075                 1080             


Glu Asp  Asn Gln Gly Ile Val  Tyr Ala Trp Val Gly  Arg Ala Ser 
    1085                 1090                 1095             


Asp Pro  Asp Glu Ala Lys Leu  Ala Glu Asp Ile Leu  Asn Thr Met 
    1100                 1105                 1110             


Phe Asp  Thr Ser Tyr Ser Lys  Gln Val Ile Asn Glu  Gly Glu Glu 
    1115                 1120                 1125             


Pro Glu  Asn Phe Phe Trp Val  Gly Ile Gly Ala Gln  Lys Pro Tyr 
    1130                 1135                 1140             


Asp Asp  Asp Ala Glu Tyr Met  Lys His Thr Arg Leu  Phe Arg Cys 
    1145                 1150                 1155             


Ser Asn  Glu Lys Gly Tyr Phe  Ala Val Thr Glu Lys  Cys Ser Asp 
    1160                 1165                 1170             


Phe Cys  Gln Asp Asp Leu Ala  Asp Asp Asp Ile Met  Leu Leu Asp 
    1175                 1180                 1185             


Asn Gly  Gln Glu Val Tyr Met  Trp Val Gly Thr Gln  Thr Ser Gln 
    1190                 1195                 1200             


Val Glu  Ile Lys Leu Ser Leu  Lys Ala Cys Gln Val  Tyr Ile Gln 
    1205                 1210                 1215             


His Met  Arg Ser Lys Glu His  Glu Arg Pro Arg Arg  Leu Arg Leu 
    1220                 1225                 1230             


Val Arg  Lys Gly Asn Glu Gln  His Ala Phe Thr Arg  Cys Phe His 
    1235                 1240                 1245             


Ala Trp  Ser Ala Phe Cys Lys  Ala Leu Ala 
    1250                 1255             


<210>  5
<211>  4222
<212>  DNA
<213>  Homo sapiens

<400>  5
aactccagca cagggggggc ccgcactcct tggtgcctcc gcagtcttcg aacagacggg       60

gaaactgagg ccctaagagg cctaaagcct acacttcccc gcggaatgcg gcgggcgcgg      120

gcgggttaaa ggggcggggc cggcgctggc ccagcccgcg gctcccccca gcgccctcgc      180

cccggcgctc cctagcccgg cgcggcccgg cagcgagagc ggcgccatgg aggccaccgg      240

ggtgctgccg ttcgtgcgtg gcgtggacct cagcggcaac gacttcaagg gcggctactt      300

ccctgagaat gtcaaggcca tgaccagcct gcggtggctg aagctgaacc gcactggcct      360

ctgctacctg cccgaggagc tggccgccct gcagaagctg gaacacttgt ctgtgagcca      420

caacaacctg accacgcttc atggggagct gtccagcctg ccatcgctgc gcgccatcgt      480

ggcccgagcc aacagtctga agaattccgg agtccccgat gacatcttca agctagatga      540

tctctcagtc ctggacttga gccacaacca gctgacagag tgcccgcggg agctggagaa      600

cgccaagaac atgctggtgc tgaacctcag ccacaacagg cagctcccag cgatgacggc      660

cctgcagacc ctgcacctgc ggagcaccca gcgcacccag agcaacctgc ccaccagcct      720

ggagggtctg agcaacctcg cagacgtgga tctgtcctgc aatgacctga cacgggtgcc      780

cgagtgtctg tacaccctcc ccagcctgcg ccgcctcaac ctcagcagca accagatcac      840

ggagctgtcc ctgtgcatag accagtgggt gcacgtggaa actctgaacc tgtcccgaaa      900

tcagctcacc tcactgccct cagccatttg caagctgagc aagctgaaga agctgtacct      960

gaattccaac aagctggact ttgacgggct gccctcaggc attggcaagc tcaccaacct     1020

ggaagagttc atggctgcca acaacaacct ggagctggtc cctgaaagtc tctgcaggtg     1080

cccaaagctg aggaaacttg tcctgaacaa gaaccacctg gtgaccctcc cagaagccat     1140

ccatttcctg acggagatcg aggtcctgga tgtgcgggag aaccccaacc tggtcatgcc     1200

gcccaagccc gcagaccgtg ccgctgagtg gtacaacatc gacttctcgc tgcagaacca     1260

gctgcggcta gcgggtgcct ctcctgctac cgtggctgca gctgcagctg ggagtgggcc     1320

caaggaccct atggctcgca agatgcgact gcggaggcgc aaggattcag cccaggatga     1380

ccaggccaag caggtgctga agggcatgtc agatgttgcc caggagaaga acaaaaagca     1440

ggaggagagc gcagatgccc gggcccccag cgggaaggtg cggcgttggg accagggcct     1500

ggagaagccc cgccttgact actccgagtt cttcacggag gacgtgggcc agctgcccgg     1560

actgaccatc tggcagatag agaacttcgt gcctgtgctg gtggaggaag ccttccacgg     1620

caagttctac gaggctgact gctacattgt gctcaagacc tttctggatg acagcggctc     1680

cctcaactgg gagatctact actggattgg cggggaggcc acactcgaca agaaagcttg     1740

ctctgccatc cacgctgtca acttgcgcaa ctacctgggt gctgagtgcc gcactgtccg     1800

ggaggagatg ggcgatgaga gcgaggagtt cctgcaggtg tttgacaacg acatctccta     1860

cattgagggt ggaacagcca gtggcttcta cactgtggaa gacacacact atgtcaccag     1920

gatgtatcgt gtgtatggga aaaagaacat caagttggag cctgtgcccc tcaaggggac     1980

ctctctggac ccaaggtttg ttttcctgct ggaccgaggg ctagacatct acgtatggcg     2040

gggggcccag gccacactga gcagcaccac caaggccagg ctctttgcag agaaaattaa     2100

caagaatgag cggaaaggga aggctgagat cacactgctg gtgcagggcc aggagctccc     2160

agagttctgg gaggcactgg gtggggagcc ctctgagatc aagaagcacg tgcctgaaga     2220

cttctggccg ccgcagccca agctgtacaa ggtgggcctg ggcttgggct acctggagct     2280

gccacagatc aactacaagc tctccgtgga acataagcag cgtcccaagg tggagctgat     2340

gccaagaatg cggctgctgc agagtctgct ggacacgcgc tgcgtgtaca ttctggactg     2400

ttggtccgac gtgttcatct ggctcggccg caagtccccg cgcctggtgc gcgctgccgc     2460

cctcaagctg ggtcaggagc tgtgcgggat gctgcaccgg ccacgccatg ccacggtcag     2520

ccgcagcctc gagggcaccg aggcgcaggt gttcaaggcc aagttcaaga attgggacga     2580

tgtgttgacg gtggactaca cacgcaatgc ggaggccgtg ctgcagagcc cgggtctctc     2640

cgggaaggtg aaacgcgacg ccgagaagaa agaccagatg aaggctgacc tcactgcgct     2700

tttcctgccg cggcagccgc ccatgtcgct ggccgaggcg gagcagctga tggaggagtg     2760

gaacgaagac ctagacggca tggagggttt cgtgctggag ggcaagaagt ttgcgcggct     2820

gccggaagag gagtttggcc acttctacac gcaggactgc tacgtcttcc tctgcaggta     2880

ctgggtgcct gtggagtacg aggaggagga aaagaaggaa gacaaggagg agaaggccga     2940

gggcaaagaa ggcgaggaag caaccgctga ggcagaggag aagcagccag aggaggactt     3000

ccagtgcatc gtgtacttct ggcagggccg tgaagcctcc aatatgggct ggctcacctt     3060

caccttcagc ctgcaaaaga agttcgagag cctcttccct gggaagctgg aggtggtacg     3120

catgacgcag cagcaggaga accccaagtt cctgtcccat ttcaagagga agttcatcat     3180

ccaccggggc aagaggaagg cggtccaggg cgcccaacag cccagcctct accagatccg     3240

caccaacggc agcgccctct gcacccggtg catccagatc aacaccgact ccagcctcct     3300

caactccgag ttctgcttca tcctcaaggt tccctttgag agtgaggaca accagggcat     3360

cgtgtatgcc tgggtgggcc gggcatcaga ccctgacgaa gccaagttgg cagaagacat     3420

cctgaacacc atgtttgaca cctcctacag caagcaggtt atcaacgaag gtgaggagcc     3480

tgagaacttc ttctgggtgg gcattggggc acagaagccc tatgatgacg atgccgagta     3540

catgaaacac acacgtctct tccggtgctc caacgagaag ggctactttg cagtgactga     3600

gaaatgctcc gacttttgcc aagatgacct ggcagatgat gacatcatgt tgctagacaa     3660

tggccaagag gtctacatgt gggtggggac ccagactagc caggtggaga tcaagctgag     3720

cctgaaggcc tgccaggtat atatccagca catgcggtcc aaggaacatg agcggccgcg     3780

ccggctgcgc ctggtccgca agggcaatga gcagcacgcc tttacccgct gcttccacgc     3840

ctggagcgcc ttctgcaagg ccctggccta agacaggctg gcacagcccc aggcttggtg     3900

aggaagagga aggggcctca tccactgtct gctagcaaag aatgtactca ggtgacacca     3960

cctgctccag ccacgtccag tgccacagtc cccagtagcc tcaagcagca ccaatgggga     4020

tgaccctgac aggtgccctc aggggtctgg gaaatccaac tctctccaca gtgtgagtgc     4080

acgtgtgaag ccccctcact cttccgctag ggataaagca gatgtggatg ccctttaaga     4140

gatattaaat gcttttattt tcaatattaa aaatcagtat ttttaatatt aaaaaaaaaa     4200

aaaaaaaaaa aaaaaaaaaa aa                                              4222


<210>  6
<211>  1214
<212>  PRT
<213>  Homo sapiens

<400>  6

Met Glu Ala Thr Gly Val Leu Pro Phe Val Arg Gly Val Asp Leu Ser 
1               5                   10                  15      


Gly Asn Asp Phe Lys Gly Gly Tyr Phe Pro Glu Asn Val Lys Ala Met 
            20                  25                  30          


Thr Ser Leu Arg Trp Leu Lys Leu Asn Arg Thr Gly Leu Cys Tyr Leu 
        35                  40                  45              


Pro Glu Glu Leu Ala Ala Leu Gln Lys Leu Glu His Leu Ser Val Ser 
    50                  55                  60                  


His Asn Asn Leu Thr Thr Leu His Gly Glu Leu Ser Ser Leu Pro Ser 
65                  70                  75                  80  


Leu Arg Ala Ile Val Ala Arg Ala Asn Ser Leu Lys Asn Ser Gly Val 
                85                  90                  95      


Pro Asp Asp Ile Phe Lys Leu Asp Asp Leu Ser Val Leu Asp Leu Ser 
            100                 105                 110         


His Asn Gln Leu Thr Glu Cys Pro Arg Glu Leu Glu Asn Ala Lys Asn 
        115                 120                 125             


Met Leu Val Leu Asn Leu Ser His Asn Arg Gln Leu Pro Ala Met Thr 
    130                 135                 140                 


Ala Leu Gln Thr Leu His Leu Arg Ser Thr Gln Arg Thr Gln Ser Asn 
145                 150                 155                 160 


Leu Pro Thr Ser Leu Glu Gly Leu Ser Asn Leu Ala Asp Val Asp Leu 
                165                 170                 175     


Ser Cys Asn Asp Leu Thr Arg Val Pro Glu Cys Leu Tyr Thr Leu Pro 
            180                 185                 190         


Ser Leu Arg Arg Leu Asn Leu Ser Ser Asn Gln Ile Thr Glu Leu Ser 
        195                 200                 205             


Leu Cys Ile Asp Gln Trp Val His Val Glu Thr Leu Asn Leu Ser Arg 
    210                 215                 220                 


Asn Gln Leu Thr Ser Leu Pro Ser Ala Ile Cys Lys Leu Ser Lys Leu 
225                 230                 235                 240 


Lys Lys Leu Tyr Leu Asn Ser Asn Lys Leu Asp Phe Asp Gly Leu Pro 
                245                 250                 255     


Ser Gly Ile Gly Lys Leu Thr Asn Leu Glu Glu Phe Met Ala Ala Asn 
            260                 265                 270         


Asn Asn Leu Glu Leu Val Pro Glu Ser Leu Cys Arg Cys Pro Lys Leu 
        275                 280                 285             


Arg Lys Leu Val Leu Asn Lys Asn His Leu Val Thr Leu Pro Glu Ala 
    290                 295                 300                 


Ile His Phe Leu Thr Glu Ile Glu Val Leu Asp Val Arg Glu Asn Pro 
305                 310                 315                 320 


Asn Leu Val Met Pro Pro Lys Pro Ala Asp Arg Ala Ala Glu Trp Tyr 
                325                 330                 335     


Asn Ile Asp Phe Ser Leu Gln Asn Gln Leu Arg Leu Ala Gly Ala Ser 
            340                 345                 350         


Pro Ala Thr Val Ala Ala Ala Ala Ala Gly Ser Gly Pro Lys Asp Pro 
        355                 360                 365             


Met Ala Arg Lys Met Arg Leu Arg Arg Arg Lys Asp Ser Ala Gln Asp 
    370                 375                 380                 


Asp Gln Ala Lys Gln Val Leu Lys Gly Met Ser Asp Val Ala Gln Glu 
385                 390                 395                 400 


Lys Asn Lys Lys Gln Glu Glu Ser Ala Asp Ala Arg Ala Pro Ser Gly 
                405                 410                 415     


Lys Val Arg Arg Trp Asp Gln Gly Leu Glu Lys Pro Arg Leu Asp Tyr 
            420                 425                 430         


Ser Glu Phe Phe Thr Glu Asp Val Gly Gln Leu Pro Gly Leu Thr Ile 
        435                 440                 445             


Trp Gln Ile Glu Asn Phe Val Pro Val Leu Val Glu Glu Ala Phe His 
    450                 455                 460                 


Gly Lys Phe Tyr Glu Ala Asp Cys Tyr Ile Val Leu Lys Thr Phe Leu 
465                 470                 475                 480 


Asp Asp Ser Gly Ser Leu Asn Trp Glu Ile Tyr Tyr Trp Ile Gly Gly 
                485                 490                 495     


Glu Ala Thr Leu Asp Lys Lys Ala Cys Ser Ala Ile His Ala Val Asn 
            500                 505                 510         


Leu Arg Asn Tyr Leu Gly Ala Glu Cys Arg Thr Val Arg Glu Glu Met 
        515                 520                 525             


Gly Asp Glu Ser Glu Glu Phe Leu Gln Val Phe Asp Asn Asp Ile Ser 
    530                 535                 540                 


Tyr Ile Glu Gly Gly Thr Ala Ser Gly Phe Tyr Thr Val Glu Asp Thr 
545                 550                 555                 560 


His Tyr Val Thr Arg Met Tyr Arg Val Tyr Gly Lys Lys Asn Ile Lys 
                565                 570                 575     


Leu Glu Pro Val Pro Leu Lys Gly Thr Ser Leu Asp Pro Arg Phe Val 
            580                 585                 590         


Phe Leu Leu Asp Arg Gly Leu Asp Ile Tyr Val Trp Arg Gly Ala Gln 
        595                 600                 605             


Ala Thr Leu Ser Ser Thr Thr Lys Ala Arg Leu Phe Ala Glu Lys Ile 
    610                 615                 620                 


Asn Lys Asn Glu Arg Lys Gly Lys Ala Glu Ile Thr Leu Leu Val Gln 
625                 630                 635                 640 


Gly Gln Glu Leu Pro Glu Phe Trp Glu Ala Leu Gly Gly Glu Pro Ser 
                645                 650                 655     


Glu Ile Lys Lys His Val Pro Glu Asp Phe Trp Pro Pro Gln Pro Lys 
            660                 665                 670         


Leu Tyr Lys Val Gly Leu Gly Leu Gly Tyr Leu Glu Leu Pro Gln Ile 
        675                 680                 685             


Asn Tyr Lys Leu Ser Val Glu His Lys Gln Arg Pro Lys Val Glu Leu 
    690                 695                 700                 


Met Pro Arg Met Arg Leu Leu Gln Ser Leu Leu Asp Thr Arg Cys Val 
705                 710                 715                 720 


Tyr Ile Leu Asp Cys Trp Ser Asp Val Phe Ile Trp Leu Gly Arg Lys 
                725                 730                 735     


Ser Pro Arg Leu Val Arg Ala Ala Ala Leu Lys Leu Gly Gln Glu Leu 
            740                 745                 750         


Cys Gly Met Leu His Arg Pro Arg His Ala Thr Val Ser Arg Ser Leu 
        755                 760                 765             


Glu Gly Thr Glu Ala Gln Val Phe Lys Ala Lys Phe Lys Asn Trp Asp 
    770                 775                 780                 


Asp Val Leu Thr Val Asp Tyr Thr Arg Asn Ala Glu Ala Val Leu Gln 
785                 790                 795                 800 


Ser Pro Gly Leu Ser Gly Lys Val Lys Arg Asp Ala Glu Lys Lys Asp 
                805                 810                 815     


Gln Met Lys Ala Asp Leu Thr Ala Leu Phe Leu Pro Arg Gln Pro Pro 
            820                 825                 830         


Met Ser Leu Ala Glu Ala Glu Gln Leu Met Glu Glu Trp Asn Glu Asp 
        835                 840                 845             


Leu Asp Gly Met Glu Gly Phe Val Leu Glu Gly Lys Lys Phe Ala Arg 
    850                 855                 860                 


Leu Pro Glu Glu Glu Phe Gly His Phe Tyr Thr Gln Asp Cys Tyr Val 
865                 870                 875                 880 


Phe Leu Cys Arg Tyr Trp Val Pro Val Glu Tyr Glu Glu Glu Glu Lys 
                885                 890                 895     


Lys Glu Asp Lys Glu Glu Lys Ala Glu Gly Lys Glu Gly Glu Glu Ala 
            900                 905                 910         


Thr Ala Glu Ala Glu Glu Lys Gln Pro Glu Glu Asp Phe Gln Cys Ile 
        915                 920                 925             


Val Tyr Phe Trp Gln Gly Arg Glu Ala Ser Asn Met Gly Trp Leu Thr 
    930                 935                 940                 


Phe Thr Phe Ser Leu Gln Lys Lys Phe Glu Ser Leu Phe Pro Gly Lys 
945                 950                 955                 960 


Leu Glu Val Val Arg Met Thr Gln Gln Gln Glu Asn Pro Lys Phe Leu 
                965                 970                 975     


Ser His Phe Lys Arg Lys Phe Ile Ile His Arg Gly Lys Arg Lys Ala 
            980                 985                 990         


Val Gln Gly Ala Gln Gln Pro Ser  Leu Tyr Gln Ile Arg  Thr Asn Gly 
        995                 1000                 1005             


Ser Ala  Leu Cys Thr Arg Cys  Ile Gln Ile Asn Thr  Asp Ser Ser 
    1010                 1015                 1020             


Leu Leu  Asn Ser Glu Phe Cys  Phe Ile Leu Lys Val  Pro Phe Glu 
    1025                 1030                 1035             


Ser Glu  Asp Asn Gln Gly Ile  Val Tyr Ala Trp Val  Gly Arg Ala 
    1040                 1045                 1050             


Ser Asp  Pro Asp Glu Ala Lys  Leu Ala Glu Asp Ile  Leu Asn Thr 
    1055                 1060                 1065             


Met Phe  Asp Thr Ser Tyr Ser  Lys Gln Val Ile Asn  Glu Gly Glu 
    1070                 1075                 1080             


Glu Pro  Glu Asn Phe Phe Trp  Val Gly Ile Gly Ala  Gln Lys Pro 
    1085                 1090                 1095             


Tyr Asp  Asp Asp Ala Glu Tyr  Met Lys His Thr Arg  Leu Phe Arg 
    1100                 1105                 1110             


Cys Ser  Asn Glu Lys Gly Tyr  Phe Ala Val Thr Glu  Lys Cys Ser 
    1115                 1120                 1125             


Asp Phe  Cys Gln Asp Asp Leu  Ala Asp Asp Asp Ile  Met Leu Leu 
    1130                 1135                 1140             


Asp Asn  Gly Gln Glu Val Tyr  Met Trp Val Gly Thr  Gln Thr Ser 
    1145                 1150                 1155             


Gln Val  Glu Ile Lys Leu Ser  Leu Lys Ala Cys Gln  Val Tyr Ile 
    1160                 1165                 1170             


Gln His  Met Arg Ser Lys Glu  His Glu Arg Pro Arg  Arg Leu Arg 
    1175                 1180                 1185             


Leu Val  Arg Lys Gly Asn Glu  Gln His Ala Phe Thr  Arg Cys Phe 
    1190                 1195                 1200             


His Ala  Trp Ser Ala Phe Cys  Lys Ala Leu Ala 
    1205                 1210                 


<210>  7
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human Flightless I peptide

<400>  7

Cys Lys Leu Glu His Leu Ser Val Ser His Asn 
1               5                   10      


<210>  8
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CYPA F Primer

<400>  8
ggttggatgg caagcatgtg                                                   20


<210>  9
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CYPA R Primer

<400>  9
tgctggtctt gccattcctg                                                   20


<210>  10
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  GAPDH F Primer

<400>  10
gggctctctg ctcctccctg t                                                 21


<210>  11
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  GAPDH R Primer

<400>  11
cggccaaatc cgttcacacc g                                                 21


<210>  12
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  TNFalpha F Primer

<400>  12
gcccacgtcg tagcaaacca c                                                 21


<210>  13
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  TNFalpha R Primer

<400>  13
gcaggggctc ttgacggcag                                                   20


<210>  14
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  IL-17A F Primer

<400>  14
ctgctgagcc tggcggctac                                                   20


<210>  15
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  IL-17A R Primer

<400>  15
cattgcggtg gagagtccag gg                                                22


<210>  16
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  IFNgamma F Primer

<400>  16
aaagagataa tctggctctg c                                                 21


<210>  17
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  IFNgamma R Primer

<400>  17
gctctgagac aatgaacgct                                                   20


<210>  18
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  IL-5 F Primer

<400>  18
agcacagtgg tgaaagagac ctt                                               23


<210>  19
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  IL-5 R Primer

<400>  19
tccaatgcat agctggtgat tt                                                22


<210>  20
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  IL-13 F Primer

<400>  20
tgggtcctgt agatggcatt g                                                 21


<210>  21
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  IL-13 R Primer

<400>  21
agaccagact cccctgagca                                                   20


<210>  22
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Axin-2 F Primer

<400>  22
tagtcccaga gcccgtcaca g                                                 21


<210>  23
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Axin-2 R Primer

<400>  23
gaacgctggc agacaggaca ta                                                22


<210>  24
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Lgr6 F Primer

<400>  24
ctgatgcacc tgaagctcaa                                                   20


<210>  25
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Lgr6 R Primer

<400>  25
acagcactgg taggcgtagg                                                   20


