                         SEQUENCE LISTING

<110>  ݶڰе＼޹˾
 
<120>  CD137弰Ӧ

<130>  0027-PA-022

<160>  166   

<170>  PatentIn version 3.5

<210>  1
<211>  14
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  C2-WT LCDR1

<400>  1

Thr Gly Ile Ser Ser Asp Val Gly Ala Tyr Asp Tyr Val Ser 
1               5                   10                  


<210>  2
<211>  7
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  C2-WT LCDR2

<400>  2

Glu Val Ser Lys Arg Pro Ser 
1               5           


<210>  3
<211>  11
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  C2-WT LCDR3

<400>  3

Ser Ser His Ala Gly Ser Asn Asn Phe Tyr Val 
1               5                   10      


<210>  4
<211>  5
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  C2-WT HCDR1

<400>  4

Asp Tyr Tyr Met Asn 
1               5   


<210>  5
<211>  19
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  C2-WT HCDR2

<400>  5

Tyr Ile Ser Ser Ser Ala Ser Gly Ser Thr Ile Tyr Tyr Ala Asp Ser 
1               5                   10                  15      


Val Lys Gly 
            


<210>  6
<211>  13
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  C2-WT HCDR3

<400>  6

Val Val Pro Ala Gly Ser Gly Trp Arg Trp Phe Asp Pro 
1               5                   10              


<210>  7
<211>  30
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  C2-WT HFR1

<400>  7

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Val Ser 
            20                  25                  30  


<210>  8
<211>  14
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  C2-WT HFR2

<400>  8

Trp Ile Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ser 
1               5                   10                  


<210>  9
<211>  32
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  C2-WT HFR3

<400>  9

Arg Phe Thr Ile Ser Arg Asp Asn Ala Asn Asn Ser Leu Tyr Leu His 
1               5                   10                  15      


Met Asp Ser Leu Arg Ala Glu Asp Thr Ala Ile Tyr Phe Cys Ala Arg 
            20                  25                  30          


<210>  10
<211>  11
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  C2-WT HFR4

<400>  10

Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
1               5                   10      


<210>  11
<211>  22
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  C2-WT LFR1

<400>  11

Gln Ser Val Leu Ile Gln Pro Pro Ser Ala Ser Gly Ser Pro Gly Gln 
1               5                   10                  15      


Ser Val Thr Ile Ser Cys 
            20          


<210>  12
<211>  15
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  C2-WT LFR2

<400>  12

Trp Tyr Gln Gln His Pro Gly Lys Val Pro Lys Leu Met Ile Tyr 
1               5                   10                  15  


<210>  13
<211>  32
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  C2-WT LFR3

<400>  13

Gly Val Pro Asp Arg Phe Ser Gly Ser Lys Ser Gly Asp Thr Ala Ser 
1               5                   10                  15      


Leu Thr Val Ser Gly Leu Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys 
            20                  25                  30          


<210>  14
<211>  10
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  C2-WT LFR4

<400>  14

Phe Gly Thr Gly Thr Lys Leu Thr Val Leu 
1               5                   10  


<210>  15
<211>  30
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  C2-4A HFR1

<400>  15

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Val Ser 
            20                  25                  30  


<210>  16
<211>  14
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  C2-4A HFR2

<400>  16

Trp Ile Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ser 
1               5                   10                  


<210>  17
<211>  32
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  C2-4A HFR3

<400>  17

Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr Leu His 
1               5                   10                  15      


Met Asp Ser Leu Arg Ala Glu Asp Thr Ala Ile Tyr Phe Cys Ala Arg 
            20                  25                  30          


<210>  18
<211>  11
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  C2-4A HFR4

<400>  18

Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
1               5                   10      


<210>  19
<211>  22
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  C2-4A LFR1

<400>  19

Gln Ser Ala Leu Ile Gln Pro Pro Ser Ala Ser Gly Ser Pro Gly Gln 
1               5                   10                  15      


Ser Val Thr Ile Ser Cys 
            20          


<210>  20
<211>  15
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  C2-4A LFR2

<400>  20

Trp Tyr Gln Gln His Pro Gly Lys Val Pro Lys Leu Met Ile Tyr 
1               5                   10                  15  


<210>  21
<211>  32
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  C2-4A LFR3

<400>  21

Gly Val Pro Asp Arg Phe Ser Gly Ser Lys Ser Gly Asn Thr Ala Ser 
1               5                   10                  15      


Leu Thr Ile Ser Gly Leu Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys 
            20                  25                  30          


<210>  22
<211>  10
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  C2-4A LFR4

<400>  22

Phe Gly Thr Gly Thr Lys Leu Thr Val Leu 
1               5                   10  


<210>  23
<211>  30
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  C2-4B HFR1

<400>  23

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Val Ser 
            20                  25                  30  


<210>  24
<211>  14
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  C2-4B HFR2

<400>  24

Trp Phe Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ser 
1               5                   10                  


<210>  25
<211>  32
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  C2-4B HFR3

<400>  25

Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr Leu His 
1               5                   10                  15      


Met Asp Ser Leu Arg Ala Glu Asp Thr Ala Ile Tyr Phe Cys Ala Arg 
            20                  25                  30          


<210>  26
<211>  11
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  C2-4B HFR4

<400>  26

Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
1               5                   10      


<210>  27
<211>  22
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  C2-4B LFR1

<400>  27

Gln Ser Val Leu Ile Gln Pro Pro Ser Val Ser Gly Ser Pro Gly Gln 
1               5                   10                  15      


Ser Val Thr Ile Ser Cys 
            20          


<210>  28
<211>  15
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  C2-4B LFR2

<400>  28

Trp Tyr Gln Gln His Pro Gly Lys Val Pro Lys Leu Met Ile Tyr 
1               5                   10                  15  


<210>  29
<211>  32
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  C2-4B LFR3

<400>  29

Gly Val Pro Asp Arg Phe Ser Gly Ser Lys Ser Gly Asp Thr Ala Ser 
1               5                   10                  15      


Leu Thr Ile Ser Gly Leu Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys 
            20                  25                  30          


<210>  30
<211>  10
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  C2-4B LFR4

<400>  30

Phe Gly Thr Gly Thr Lys Leu Thr Val Leu 
1               5                   10  


<210>  31
<211>  30
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  C2-4C HFR1

<400>  31

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Val Ser 
            20                  25                  30  


<210>  32
<211>  14
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  C2-4C HFR2

<400>  32

Trp Ile Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ser 
1               5                   10                  


<210>  33
<211>  32
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  C2-4C HFR3

<400>  33

Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr Leu Gln 
1               5                   10                  15      


Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Ile Tyr Phe Cys Ala Arg 
            20                  25                  30          


<210>  34
<211>  11
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  C2-4C HFR4

<400>  34

Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
1               5                   10      


<210>  35
<211>  22
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  C2-4C LFR1

<400>  35

Gln Ser Val Leu Ile Gln Pro Pro Ser Ala Ser Gly Ser Pro Gly Gln 
1               5                   10                  15      


Ser Val Thr Ile Ser Cys 
            20          


<210>  36
<211>  15
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  C2-4C LFR2

<400>  36

Trp Tyr Gln Gln His Pro Gly Lys Val Pro Lys Leu Met Ile Tyr 
1               5                   10                  15  


<210>  37
<211>  32
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  C2-4C LFR3

<400>  37

Gly Val Pro Asp Arg Phe Ser Gly Ser Lys Ser Gly Asn Thr Ala Ser 
1               5                   10                  15      


Leu Thr Val Ser Gly Leu Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys 
            20                  25                  30          


<210>  38
<211>  10
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  C2-4C LFR4

<400>  38

Phe Gly Thr Gly Thr Lys Leu Thr Val Leu 
1               5                   10  


<210>  39
<211>  30
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  C2-5A HFR1

<400>  39

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Val Ser 
            20                  25                  30  


<210>  40
<211>  14
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  C2-5A HFR2

<400>  40

Trp Ile Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ser 
1               5                   10                  


<210>  41
<211>  32
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  C2-5A HFR3

<400>  41

Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr Leu His 
1               5                   10                  15      


Met Asp Ser Leu Arg Ala Glu Asp Thr Ala Ile Tyr Phe Cys Ala Arg 
            20                  25                  30          


<210>  42
<211>  11
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  C2-5A HFR4

<400>  42

Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
1               5                   10      


<210>  43
<211>  22
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  C2-5A LFR1

<400>  43

Gln Ser Val Leu Ile Gln Pro Pro Ser Val Ser Gly Ser Pro Gly Gln 
1               5                   10                  15      


Ser Val Thr Ile Ser Cys 
            20          


<210>  44
<211>  15
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  C2-5A LFR2

<400>  44

Trp Tyr Gln Gln His Pro Gly Lys Val Pro Lys Leu Met Ile Tyr 
1               5                   10                  15  


<210>  45
<211>  32
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  C2-5A LFR3

<400>  45

Gly Val Pro Asp Arg Phe Ser Gly Ser Lys Ser Gly Asn Thr Ala Ser 
1               5                   10                  15      


Leu Thr Ile Ser Gly Leu Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys 
            20                  25                  30          


<210>  46
<211>  10
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  C2-5A LFR4

<400>  46

Phe Gly Thr Gly Thr Lys Leu Thr Val Leu 
1               5                   10  


<210>  47
<211>  30
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  C2-5B HFR1

<400>  47

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Val Ser 
            20                  25                  30  


<210>  48
<211>  14
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  C2-5B HFR2

<400>  48

Trp Ile Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ser 
1               5                   10                  


<210>  49
<211>  32
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  C2-5B HFR3

<400>  49

Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr Leu Gln 
1               5                   10                  15      


Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Ile Tyr Phe Cys Ala Arg 
            20                  25                  30          


<210>  50
<211>  11
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  C2-5B HFR4

<400>  50

Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
1               5                   10      


<210>  51
<211>  22
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  C2-5B LFR1

<400>  51

Gln Ser Val Leu Ile Gln Pro Pro Ser Ala Ser Gly Ser Pro Gly Gln 
1               5                   10                  15      


Ser Val Thr Ile Ser Cys 
            20          


<210>  52
<211>  15
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  C2-5B LFR2

<400>  52

Trp Tyr Gln Gln His Pro Gly Lys Val Pro Lys Leu Met Ile Tyr 
1               5                   10                  15  


<210>  53
<211>  32
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  C2-5B LFR3

<400>  53

Gly Val Pro Asp Arg Phe Ser Gly Ser Lys Ser Gly Asn Thr Ala Ser 
1               5                   10                  15      


Leu Thr Ile Ser Gly Leu Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys 
            20                  25                  30          


<210>  54
<211>  10
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  C2-5B LFR4

<400>  54

Phe Gly Thr Gly Thr Lys Leu Thr Val Leu 
1               5                   10  


<210>  55
<211>  30
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  C2-5C HFR1

<400>  55

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Val Ser 
            20                  25                  30  


<210>  56
<211>  14
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  C2-5C HFR2

<400>  56

Trp Phe Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ser 
1               5                   10                  


<210>  57
<211>  32
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  C2-5C HFR3

<400>  57

Arg Phe Thr Ile Ser Arg Asp Asn Ala Asn Asn Ser Leu Tyr Leu His 
1               5                   10                  15      


Met Asp Ser Leu Arg Ala Glu Asp Thr Ala Ile Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  58
<211>  11
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  C2-5C HFR4

<400>  58

Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
1               5                   10      


<210>  59
<211>  22
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  C2-5C LFR1

<400>  59

Gln Ser Val Leu Ile Gln Pro Pro Ser Val Ser Gly Ser Pro Gly Gln 
1               5                   10                  15      


Ser Val Thr Ile Ser Cys 
            20          


<210>  60
<211>  15
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  C2-5C LFR2

<400>  60

Trp Tyr Gln Gln His Pro Gly Lys Val Pro Lys Leu Met Ile Tyr 
1               5                   10                  15  


<210>  61
<211>  32
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  C2-5C LFR3

<400>  61

Gly Val Pro Asp Arg Phe Ser Gly Ser Lys Ser Gly Asp Thr Ala Ser 
1               5                   10                  15      


Leu Thr Ile Ser Gly Leu Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys 
            20                  25                  30          


<210>  62
<211>  10
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  C2-5C LFR4

<400>  62

Phe Gly Thr Gly Thr Lys Leu Thr Val Leu 
1               5                   10  


<210>  63
<211>  30
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  C2-6A HFR1

<400>  63

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Val Ser 
            20                  25                  30  


<210>  64
<211>  14
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  C2-6A HFR2

<400>  64

Trp Ile Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ser 
1               5                   10                  


<210>  65
<211>  32
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  C2-6A HFR3

<400>  65

Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr Leu Gln 
1               5                   10                  15      


Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Ile Tyr Phe Cys Ala Arg 
            20                  25                  30          


<210>  66
<211>  11
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  C2-6A HFR4

<400>  66

Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
1               5                   10      


<210>  67
<211>  22
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  C2-6A LFR1

<400>  67

Gln Ser Val Leu Ile Gln Pro Pro Ser Val Ser Gly Ser Pro Gly Gln 
1               5                   10                  15      


Ser Val Thr Ile Ser Cys 
            20          


<210>  68
<211>  15
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  C2-6A LFR2

<400>  68

Trp Tyr Gln Gln His Pro Gly Lys Val Pro Lys Leu Met Ile Tyr 
1               5                   10                  15  


<210>  69
<211>  32
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  C2-6A LFR3

<400>  69

Gly Val Pro Asp Arg Phe Ser Gly Ser Lys Ser Gly Asn Thr Ala Ser 
1               5                   10                  15      


Leu Thr Ile Ser Gly Leu Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys 
            20                  25                  30          


<210>  70
<211>  10
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  C2-6A LFR4

<400>  70

Phe Gly Thr Gly Thr Lys Leu Thr Val Leu 
1               5                   10  


<210>  71
<211>  30
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  C2-6B HFR1

<400>  71

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Val Ser 
            20                  25                  30  


<210>  72
<211>  14
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  C2-6B HFR2

<400>  72

Trp Ile Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ser 
1               5                   10                  


<210>  73
<211>  32
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  C2-6B HFR3

<400>  73

Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr Leu Gln 
1               5                   10                  15      


Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Ile Tyr Phe Cys Ala Arg 
            20                  25                  30          


<210>  74
<211>  11
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  C2-6B HFR4

<400>  74

Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
1               5                   10      


<210>  75
<211>  22
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  C2-6B LFR1

<400>  75

Gln Ser Val Leu Ile Gln Pro Pro Ser Val Ser Gly Ser Pro Gly Gln 
1               5                   10                  15      


Ser Val Thr Ile Ser Cys 
            20          


<210>  76
<211>  15
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  C2-6B LFR2

<400>  76

Trp Tyr Gln Gln His Pro Gly Lys Val Pro Lys Leu Met Ile Tyr 
1               5                   10                  15  


<210>  77
<211>  32
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  C2-6B LFR3

<400>  77

Gly Val Pro Asp Arg Phe Ser Gly Ser Lys Ser Gly Asn Thr Ala Ser 
1               5                   10                  15      


Leu Thr Val Ser Gly Leu Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys 
            20                  25                  30          


<210>  78
<211>  10
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  C2-6B LFR4

<400>  78

Phe Gly Thr Gly Thr Lys Leu Thr Val Leu 
1               5                   10  


<210>  79
<211>  30
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  C2-7A HFR1

<400>  79

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Val Ser 
            20                  25                  30  


<210>  80
<211>  14
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  C2-7A HFR2

<400>  80

Trp Ile Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ser 
1               5                   10                  


<210>  81
<211>  32
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  C2-7A HFR3

<400>  81

Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr Leu His 
1               5                   10                  15      


Met Asp Ser Leu Arg Ala Glu Asp Thr Ala Ile Tyr Phe Cys Ala Arg 
            20                  25                  30          


<210>  82
<211>  11
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  C2-7A HFR4

<400>  82

Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
1               5                   10      


<210>  83
<211>  22
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  C2-7A LFR1

<400>  83

Gln Ser Ala Leu Ile Gln Pro Pro Ser Val Ser Gly Ser Pro Gly Gln 
1               5                   10                  15      


Ser Val Thr Ile Ser Cys 
            20          


<210>  84
<211>  15
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  C2-7A LFR2

<400>  84

Trp Tyr Gln Gln His Pro Gly Thr Val Pro Lys Leu Met Ile Tyr 
1               5                   10                  15  


<210>  85
<211>  32
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  C2-7A LFR3

<400>  85

Gly Val Pro Asp Arg Phe Ser Gly Ser Lys Ser Gly Asn Thr Ala Ser 
1               5                   10                  15      


Leu Thr Ile Ser Gly Leu Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys 
            20                  25                  30          


<210>  86
<211>  10
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  C2-7A LFR4

<400>  86

Phe Gly Thr Gly Thr Lys Leu Thr Val Leu 
1               5                   10  


<210>  87
<211>  30
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  C2-7B HFR1

<400>  87

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Val Ser 
            20                  25                  30  


<210>  88
<211>  14
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  C2-7B HFR2

<400>  88

Trp Ile Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ser 
1               5                   10                  


<210>  89
<211>  32
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  C2-7B HFR3

<400>  89

Arg Phe Thr Ile Ser Arg Asp Asn Ala Asn Asn Ser Leu Tyr Leu Gln 
1               5                   10                  15      


Met Asn Ser Leu Arg Thr Glu Asp Thr Ala Ile Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  90
<211>  11
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  C2-7B HFR4

<400>  90

Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
1               5                   10      


<210>  91
<211>  22
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  C2-7B LFR1

<400>  91

Gln Ser Val Leu Ile Gln Pro Pro Ser Val Ser Gly Ser Pro Gly Gln 
1               5                   10                  15      


Ser Val Thr Ile Ser Cys 
            20          


<210>  92
<211>  15
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  C2-7B LFR2

<400>  92

Trp Tyr Gln Gln His Pro Gly Lys Val Pro Lys Leu Met Ile Tyr 
1               5                   10                  15  


<210>  93
<211>  32
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  C2-7B LFR3

<400>  93

Gly Val Pro Asp Arg Phe Ser Gly Ser Lys Ser Gly Asp Thr Ala Ser 
1               5                   10                  15      


Leu Thr Ile Ser Gly Leu Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys 
            20                  25                  30          


<210>  94
<211>  10
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  C2-7B LFR4

<400>  94

Phe Gly Thr Gly Thr Lys Leu Thr Val Leu 
1               5                   10  


<210>  95
<211>  30
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  C2-7BN78K HFR1

<400>  95

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Val Ser 
            20                  25                  30  


<210>  96
<211>  14
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  C2-7BN78K HFR2

<400>  96

Trp Ile Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ser 
1               5                   10                  


<210>  97
<211>  32
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  C2-7BN78K HFR3

<400>  97

Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr Leu Gln 
1               5                   10                  15      


Met Asn Ser Leu Arg Thr Glu Asp Thr Ala Ile Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  98
<211>  11
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  C2-7BN78K HFR4

<400>  98

Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
1               5                   10      


<210>  99
<211>  22
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  C2-7BN78K LFR1

<400>  99

Gln Ser Val Leu Ile Gln Pro Pro Ser Val Ser Gly Ser Pro Gly Gln 
1               5                   10                  15      


Ser Val Thr Ile Ser Cys 
            20          


<210>  100
<211>  15
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  C2-7BN78K LFR2

<400>  100

Trp Tyr Gln Gln His Pro Gly Lys Val Pro Lys Leu Met Ile Tyr 
1               5                   10                  15  


<210>  101
<211>  32
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  C2-7BN78K LFR3

<400>  101

Gly Val Pro Asp Arg Phe Ser Gly Ser Lys Ser Gly Asp Thr Ala Ser 
1               5                   10                  15      


Leu Thr Ile Ser Gly Leu Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys 
            20                  25                  30          


<210>  102
<211>  10
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  C2-7BN78K LFR4

<400>  102

Phe Gly Thr Gly Thr Lys Leu Thr Val Leu 
1               5                   10  


<210>  103
<211>  111
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  C2-WT VL

<400>  103

Gln Ser Val Leu Ile Gln Pro Pro Ser Ala Ser Gly Ser Pro Gly Gln 
1               5                   10                  15      


Ser Val Thr Ile Ser Cys Thr Gly Ile Ser Ser Asp Val Gly Ala Tyr 
            20                  25                  30          


Asp Tyr Val Ser Trp Tyr Gln Gln His Pro Gly Lys Val Pro Lys Leu 
        35                  40                  45              


Met Ile Tyr Glu Val Ser Lys Arg Pro Ser Gly Val Pro Asp Arg Phe 
    50                  55                  60                  


Ser Gly Ser Lys Ser Gly Asp Thr Ala Ser Leu Thr Val Ser Gly Leu 
65                  70                  75                  80  


Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Ser Ser His Ala Gly Ser 
                85                  90                  95      


Asn Asn Phe Tyr Val Phe Gly Thr Gly Thr Lys Leu Thr Val Leu 
            100                 105                 110     


<210>  104
<211>  111
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  C2-4A VL

<400>  104

Gln Ser Ala Leu Ile Gln Pro Pro Ser Ala Ser Gly Ser Pro Gly Gln 
1               5                   10                  15      


Ser Val Thr Ile Ser Cys Thr Gly Ile Ser Ser Asp Val Gly Ala Tyr 
            20                  25                  30          


Asp Tyr Val Ser Trp Tyr Gln Gln His Pro Gly Lys Val Pro Lys Leu 
        35                  40                  45              


Met Ile Tyr Glu Val Ser Lys Arg Pro Ser Gly Val Pro Asp Arg Phe 
    50                  55                  60                  


Ser Gly Ser Lys Ser Gly Asn Thr Ala Ser Leu Thr Ile Ser Gly Leu 
65                  70                  75                  80  


Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Ser Ser His Ala Gly Ser 
                85                  90                  95      


Asn Asn Phe Tyr Val Phe Gly Thr Gly Thr Lys Leu Thr Val Leu 
            100                 105                 110     


<210>  105
<211>  111
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  C2-4B VL

<400>  105

Gln Ser Val Leu Ile Gln Pro Pro Ser Val Ser Gly Ser Pro Gly Gln 
1               5                   10                  15      


Ser Val Thr Ile Ser Cys Thr Gly Ile Ser Ser Asp Val Gly Ala Tyr 
            20                  25                  30          


Asp Tyr Val Ser Trp Tyr Gln Gln His Pro Gly Lys Val Pro Lys Leu 
        35                  40                  45              


Met Ile Tyr Glu Val Ser Lys Arg Pro Ser Gly Val Pro Asp Arg Phe 
    50                  55                  60                  


Ser Gly Ser Lys Ser Gly Asp Thr Ala Ser Leu Thr Ile Ser Gly Leu 
65                  70                  75                  80  


Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Ser Ser His Ala Gly Ser 
                85                  90                  95      


Asn Asn Phe Tyr Val Phe Gly Thr Gly Thr Lys Leu Thr Val Leu 
            100                 105                 110     


<210>  106
<211>  111
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  C2-4C VL

<400>  106

Gln Ser Val Leu Ile Gln Pro Pro Ser Ala Ser Gly Ser Pro Gly Gln 
1               5                   10                  15      


Ser Val Thr Ile Ser Cys Thr Gly Ile Ser Ser Asp Val Gly Ala Tyr 
            20                  25                  30          


Asp Tyr Val Ser Trp Tyr Gln Gln His Pro Gly Lys Val Pro Lys Leu 
        35                  40                  45              


Met Ile Tyr Glu Val Ser Lys Arg Pro Ser Gly Val Pro Asp Arg Phe 
    50                  55                  60                  


Ser Gly Ser Lys Ser Gly Asn Thr Ala Ser Leu Thr Val Ser Gly Leu 
65                  70                  75                  80  


Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Ser Ser His Ala Gly Ser 
                85                  90                  95      


Asn Asn Phe Tyr Val Phe Gly Thr Gly Thr Lys Leu Thr Val Leu 
            100                 105                 110     


<210>  107
<211>  111
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  C2-5A VL

<400>  107

Gln Ser Val Leu Ile Gln Pro Pro Ser Val Ser Gly Ser Pro Gly Gln 
1               5                   10                  15      


Ser Val Thr Ile Ser Cys Thr Gly Ile Ser Ser Asp Val Gly Ala Tyr 
            20                  25                  30          


Asp Tyr Val Ser Trp Tyr Gln Gln His Pro Gly Lys Val Pro Lys Leu 
        35                  40                  45              


Met Ile Tyr Glu Val Ser Lys Arg Pro Ser Gly Val Pro Asp Arg Phe 
    50                  55                  60                  


Ser Gly Ser Lys Ser Gly Asn Thr Ala Ser Leu Thr Ile Ser Gly Leu 
65                  70                  75                  80  


Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Ser Ser His Ala Gly Ser 
                85                  90                  95      


Asn Asn Phe Tyr Val Phe Gly Thr Gly Thr Lys Leu Thr Val Leu 
            100                 105                 110     


<210>  108
<211>  111
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  C2-5B VL

<400>  108

Gln Ser Val Leu Ile Gln Pro Pro Ser Ala Ser Gly Ser Pro Gly Gln 
1               5                   10                  15      


Ser Val Thr Ile Ser Cys Thr Gly Ile Ser Ser Asp Val Gly Ala Tyr 
            20                  25                  30          


Asp Tyr Val Ser Trp Tyr Gln Gln His Pro Gly Lys Val Pro Lys Leu 
        35                  40                  45              


Met Ile Tyr Glu Val Ser Lys Arg Pro Ser Gly Val Pro Asp Arg Phe 
    50                  55                  60                  


Ser Gly Ser Lys Ser Gly Asn Thr Ala Ser Leu Thr Ile Ser Gly Leu 
65                  70                  75                  80  


Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Ser Ser His Ala Gly Ser 
                85                  90                  95      


Asn Asn Phe Tyr Val Phe Gly Thr Gly Thr Lys Leu Thr Val Leu 
            100                 105                 110     


<210>  109
<211>  111
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  C2-5C VL

<400>  109

Gln Ser Val Leu Ile Gln Pro Pro Ser Val Ser Gly Ser Pro Gly Gln 
1               5                   10                  15      


Ser Val Thr Ile Ser Cys Thr Gly Ile Ser Ser Asp Val Gly Ala Tyr 
            20                  25                  30          


Asp Tyr Val Ser Trp Tyr Gln Gln His Pro Gly Lys Val Pro Lys Leu 
        35                  40                  45              


Met Ile Tyr Glu Val Ser Lys Arg Pro Ser Gly Val Pro Asp Arg Phe 
    50                  55                  60                  


Ser Gly Ser Lys Ser Gly Asp Thr Ala Ser Leu Thr Ile Ser Gly Leu 
65                  70                  75                  80  


Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Ser Ser His Ala Gly Ser 
                85                  90                  95      


Asn Asn Phe Tyr Val Phe Gly Thr Gly Thr Lys Leu Thr Val Leu 
            100                 105                 110     


<210>  110
<211>  111
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  C2-6A VL

<400>  110

Gln Ser Val Leu Ile Gln Pro Pro Ser Val Ser Gly Ser Pro Gly Gln 
1               5                   10                  15      


Ser Val Thr Ile Ser Cys Thr Gly Ile Ser Ser Asp Val Gly Ala Tyr 
            20                  25                  30          


Asp Tyr Val Ser Trp Tyr Gln Gln His Pro Gly Lys Val Pro Lys Leu 
        35                  40                  45              


Met Ile Tyr Glu Val Ser Lys Arg Pro Ser Gly Val Pro Asp Arg Phe 
    50                  55                  60                  


Ser Gly Ser Lys Ser Gly Asn Thr Ala Ser Leu Thr Ile Ser Gly Leu 
65                  70                  75                  80  


Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Ser Ser His Ala Gly Ser 
                85                  90                  95      


Asn Asn Phe Tyr Val Phe Gly Thr Gly Thr Lys Leu Thr Val Leu 
            100                 105                 110     


<210>  111
<211>  111
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  C2-6B VL

<400>  111

Gln Ser Val Leu Ile Gln Pro Pro Ser Val Ser Gly Ser Pro Gly Gln 
1               5                   10                  15      


Ser Val Thr Ile Ser Cys Thr Gly Ile Ser Ser Asp Val Gly Ala Tyr 
            20                  25                  30          


Asp Tyr Val Ser Trp Tyr Gln Gln His Pro Gly Lys Val Pro Lys Leu 
        35                  40                  45              


Met Ile Tyr Glu Val Ser Lys Arg Pro Ser Gly Val Pro Asp Arg Phe 
    50                  55                  60                  


Ser Gly Ser Lys Ser Gly Asn Thr Ala Ser Leu Thr Val Ser Gly Leu 
65                  70                  75                  80  


Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Ser Ser His Ala Gly Ser 
                85                  90                  95      


Asn Asn Phe Tyr Val Phe Gly Thr Gly Thr Lys Leu Thr Val Leu 
            100                 105                 110     


<210>  112
<211>  111
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  C2-7A VL

<400>  112

Gln Ser Ala Leu Ile Gln Pro Pro Ser Val Ser Gly Ser Pro Gly Gln 
1               5                   10                  15      


Ser Val Thr Ile Ser Cys Thr Gly Ile Ser Ser Asp Val Gly Ala Tyr 
            20                  25                  30          


Asp Tyr Val Ser Trp Tyr Gln Gln His Pro Gly Thr Val Pro Lys Leu 
        35                  40                  45              


Met Ile Tyr Glu Val Ser Lys Arg Pro Ser Gly Val Pro Asp Arg Phe 
    50                  55                  60                  


Ser Gly Ser Lys Ser Gly Asn Thr Ala Ser Leu Thr Ile Ser Gly Leu 
65                  70                  75                  80  


Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Ser Ser His Ala Gly Ser 
                85                  90                  95      


Asn Asn Phe Tyr Val Phe Gly Thr Gly Thr Lys Leu Thr Val Leu 
            100                 105                 110     


<210>  113
<211>  111
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  C2-7B VL

<400>  113

Gln Ser Val Leu Ile Gln Pro Pro Ser Val Ser Gly Ser Pro Gly Gln 
1               5                   10                  15      


Ser Val Thr Ile Ser Cys Thr Gly Ile Ser Ser Asp Val Gly Ala Tyr 
            20                  25                  30          


Asp Tyr Val Ser Trp Tyr Gln Gln His Pro Gly Lys Val Pro Lys Leu 
        35                  40                  45              


Met Ile Tyr Glu Val Ser Lys Arg Pro Ser Gly Val Pro Asp Arg Phe 
    50                  55                  60                  


Ser Gly Ser Lys Ser Gly Asp Thr Ala Ser Leu Thr Ile Ser Gly Leu 
65                  70                  75                  80  


Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Ser Ser His Ala Gly Ser 
                85                  90                  95      


Asn Asn Phe Tyr Val Phe Gly Thr Gly Thr Lys Leu Thr Val Leu 
            100                 105                 110     


<210>  114
<211>  111
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  C2-7BN78K VL

<400>  114

Gln Ser Val Leu Ile Gln Pro Pro Ser Val Ser Gly Ser Pro Gly Gln 
1               5                   10                  15      


Ser Val Thr Ile Ser Cys Thr Gly Ile Ser Ser Asp Val Gly Ala Tyr 
            20                  25                  30          


Asp Tyr Val Ser Trp Tyr Gln Gln His Pro Gly Lys Val Pro Lys Leu 
        35                  40                  45              


Met Ile Tyr Glu Val Ser Lys Arg Pro Ser Gly Val Pro Asp Arg Phe 
    50                  55                  60                  


Ser Gly Ser Lys Ser Gly Asp Thr Ala Ser Leu Thr Ile Ser Gly Leu 
65                  70                  75                  80  


Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Ser Ser His Ala Gly Ser 
                85                  90                  95      


Asn Asn Phe Tyr Val Phe Gly Thr Gly Thr Lys Leu Thr Val Leu 
            100                 105                 110     


<210>  115
<211>  333
<212>  DNA
<213>  ˹УArtificial Sequence

<220>
<223>  C2-WT VL 

<400>  115
cagtctgttc tgattcagcc tccctccgcg tccgggtctc ctggacagtc agtcaccatc       60

tcctgcactg gaatcagcag tgacgttggt gcttatgact atgtctcctg gtaccaacag      120

cacccaggca aagtccccaa actcatgatt tatgaggtca gtaagcggcc ctcaggggtc      180

cctgatcgct tctctggctc caagtctggc gacacggcct ccctgaccgt ctctgggctc      240

caggctgagg atgaggctga ttactactgc agctcacatg caggcagcaa caatttttat      300

gtcttcggaa ctgggaccaa gctgaccgtc cta                                   333


<210>  116
<211>  333
<212>  DNA
<213>  ˹УArtificial Sequence

<220>
<223>  C2-4A VL 

<400>  116
cagagcgccc tgatccagcc ccccagcgcc agcggcagcc ccggccagag cgtgaccatc       60

agctgcaccg gcatcagcag cgacgtgggc gcctacgact acgtgagctg gtaccagcag      120

caccccggca aggtgcccaa gctgatgatc tacgaggtga gcaagaggcc cagcggcgtg      180

cccgacaggt tcagcggcag caagagcggc aacaccgcca gcctgaccat cagcggcctg      240

caggccgagg acgaggccga ctactactgc agcagccacg ccggcagcaa caacttctac      300

gtgttcggca ccggcaccaa gctgaccgtg ctg                                   333


<210>  117
<211>  333
<212>  DNA
<213>  ˹УArtificial Sequence

<220>
<223>  C2-4B VL 

<400>  117
cagtccgtgc tgatccagcc tccttccgtg agcggaagcc ctggccagtc cgtcaccatc       60

agctgcaccg gaatcagctc cgacgtgggc gcctacgact acgtgagctg gtatcaacag      120

caccccggca aggtgcccaa gctgatgatc tacgaggtga gcaagaggcc tagcggcgtg      180

cccgacaggt ttagcggcag caagtctggt gacaccgcca gcctgaccat cagcggactg      240

caggccgaag acgaggccga ctactactgc agctcccatg ccggctccaa caacttttac      300

gtgttcggca ccggcaccaa gctgacagtg ctg                                   333


<210>  118
<211>  333
<212>  DNA
<213>  ˹УArtificial Sequence

<220>
<223>  C2-4C VL 

<400>  118
cagagcgtgc tgatccagcc ccccagcgcc agcggcagcc ccggccagag cgtgaccatc       60

agctgcaccg gcatcagcag cgacgtgggc gcctacgact acgtgagctg gtaccagcag      120

caccccggca aggtgcccaa gctgatgatc tacgaggtga gcaagaggcc cagcggcgtg      180

cccgacaggt tcagcggcag caagagcggc aacaccgcca gcctgaccgt gagcggcctg      240

caggccgagg acgaggccga ctactactgc agcagccacg ccggcagcaa caacttctac      300

gtgttcggca ccggcaccaa gctgaccgtg ctg                                   333


<210>  119
<211>  333
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  C2-5A VL 

<400>  119

Cys Ala Gly Ala Gly Cys Gly Thr Gly Cys Thr Gly Ala Thr Cys Cys 
1               5                   10                  15      


Ala Gly Cys Cys Cys Cys Cys Cys Ala Gly Cys Gly Thr Gly Ala Gly 
            20                  25                  30          


Cys Gly Gly Cys Ala Gly Cys Cys Cys Cys Gly Gly Cys Cys Ala Gly 
        35                  40                  45              


Ala Gly Cys Gly Thr Gly Ala Cys Cys Ala Thr Cys Ala Gly Cys Thr 
    50                  55                  60                  


Gly Cys Ala Cys Cys Gly Gly Cys Ala Thr Cys Ala Gly Cys Ala Gly 
65                  70                  75                  80  


Cys Gly Ala Cys Gly Thr Gly Gly Gly Cys Gly Cys Cys Thr Ala Cys 
                85                  90                  95      


Gly Ala Cys Thr Ala Cys Gly Thr Gly Ala Gly Cys Thr Gly Gly Thr 
            100                 105                 110         


Ala Cys Cys Ala Gly Cys Ala Gly Cys Ala Cys Cys Cys Cys Gly Gly 
        115                 120                 125             


Cys Ala Ala Gly Gly Thr Gly Cys Cys Cys Ala Ala Gly Cys Thr Gly 
    130                 135                 140                 


Ala Thr Gly Ala Thr Cys Thr Ala Cys Gly Ala Gly Gly Thr Gly Ala 
145                 150                 155                 160 


Gly Cys Ala Ala Gly Ala Gly Gly Cys Cys Cys Ala Gly Cys Gly Gly 
                165                 170                 175     


Cys Gly Thr Gly Cys Cys Cys Gly Ala Cys Ala Gly Gly Thr Thr Cys 
            180                 185                 190         


Ala Gly Cys Gly Gly Cys Ala Gly Cys Ala Ala Gly Ala Gly Cys Gly 
        195                 200                 205             


Gly Cys Ala Ala Cys Ala Cys Cys Gly Cys Cys Ala Gly Cys Cys Thr 
    210                 215                 220                 


Gly Ala Cys Cys Ala Thr Cys Ala Gly Cys Gly Gly Cys Cys Thr Gly 
225                 230                 235                 240 


Cys Ala Gly Gly Cys Cys Gly Ala Gly Gly Ala Cys Gly Ala Gly Gly 
                245                 250                 255     


Cys Cys Gly Ala Cys Thr Ala Cys Thr Ala Cys Thr Gly Cys Ala Gly 
            260                 265                 270         


Cys Ala Gly Cys Cys Ala Cys Gly Cys Cys Gly Gly Cys Ala Gly Cys 
        275                 280                 285             


Ala Ala Cys Ala Ala Cys Thr Thr Cys Thr Ala Cys Gly Thr Gly Thr 
    290                 295                 300                 


Thr Cys Gly Gly Cys Ala Cys Cys Gly Gly Cys Ala Cys Cys Ala Ala 
305                 310                 315                 320 


Gly Cys Thr Gly Ala Cys Cys Gly Thr Gly Cys Thr Gly 
                325                 330             


<210>  120
<211>  333
<212>  DNA
<213>  ˹УArtificial Sequence

<220>
<223>  C2-5B VL 

<400>  120
cagagcgtgc tgatccagcc ccccagcgcc agcggcagcc ccggccagag cgtgaccatc       60

agctgcaccg gcatcagcag cgacgtgggc gcctacgact acgtgagctg gtaccagcag      120

caccccggca aggtgcccaa gctgatgatc tacgaggtga gcaagaggcc cagcggcgtg      180

cccgacaggt tcagcggcag caagagcggc aacaccgcca gcctgaccat cagcggcctg      240

caggccgagg acgaggccga ctactactgc agcagccacg ccggcagcaa caacttctac      300

gtgttcggca ccggcaccaa gctgaccgtg ctg                                   333


<210>  121
<211>  333
<212>  DNA
<213>  ˹УArtificial Sequence

<220>
<223>  C2-5C VL 

<400>  121
cagagcgtgc tgatccagcc ccccagcgtg agcggcagcc ccggccagag cgtgaccatc       60

agctgcaccg gcatcagcag cgacgtgggc gcctacgact acgtgagctg gtaccagcag      120

caccccggca aggtgcccaa gctgatgatc tacgaggtga gcaagaggcc cagcggcgtg      180

cccgacaggt tcagcggcag caagagcggc gacaccgcca gcctgaccat cagcggcctg      240

caggccgagg acgaggccga ctactactgc agcagccacg ccggcagcaa caacttctac      300

gtgttcggca ccggcaccaa gctgaccgtg ctg                                   333


<210>  122
<211>  333
<212>  DNA
<213>  ˹УArtificial Sequence

<220>
<223>  C2-6A VL 

<400>  122
cagagcgtgc tgatccagcc ccccagcgtg agcggcagcc ccggccagag cgtgaccatc       60

agctgcaccg gcatcagcag cgacgtgggc gcctacgact acgtgagctg gtaccagcag      120

caccccggca aggtgcccaa gctgatgatc tacgaggtga gcaagaggcc cagcggcgtg      180

cccgacaggt tcagcggcag caagagcggc aacaccgcca gcctgaccat cagcggcctg      240

caggccgagg acgaggccga ctactactgc agcagccacg ccggcagcaa caacttctac      300

gtgttcggca ccggcaccaa gctgaccgtg ctg                                   333


<210>  123
<211>  333
<212>  DNA
<213>  ˹УArtificial Sequence

<220>
<223>  C2-6B VL 

<400>  123
cagagcgtgc tgatccagcc ccccagcgtg agcggcagcc ccggccagag cgtgaccatc       60

agctgcaccg gcatcagcag cgacgtgggc gcctacgact acgtgagctg gtaccagcag      120

caccccggca aggtgcccaa gctgatgatc tacgaggtga gcaagaggcc cagcggcgtg      180

cccgacaggt tcagcggcag caagagcggc aacaccgcca gcctgaccgt gagcggcctg      240

caggccgagg acgaggccga ctactactgc agcagccacg ccggcagcaa caacttctac      300

gtgttcggca ccggcaccaa gctgaccgtg ctg                                   333


<210>  124
<211>  333
<212>  DNA
<213>  ˹УArtificial Sequence

<220>
<223>  C2-7A VL 

<400>  124
cagagcgccc tgatccagcc tccttccgtg agcggcagcc ctggacagag cgtgaccatc       60

tcctgcaccg gaatcagcag cgacgtgggc gcctacgact atgtgagctg gtatcaacag      120

caccccggaa ccgtccccaa gctcatgatc tacgaggtga gcaagaggcc cagcggagtg      180

cccgataggt tctccggcag caaaagcggc aataccgcta gcctgaccat tagcggcctg      240

caggccgagg atgaggccga ctactactgc agcagccacg ccggctccaa caacttctat      300

gtgttcggca ccggcaccaa actgaccgtg ctg                                   333


<210>  125
<211>  333
<212>  DNA
<213>  ˹УArtificial Sequence

<220>
<223>  C2-7B VL 

<400>  125
cagagcgtgc tgattcagcc tcccagcgtg agcggaagcc ctggacagag cgtgaccatc       60

agctgcaccg gcatcagctc cgatgtgggc gcctacgact acgtgagctg gtatcaacag      120

caccctggca aggtgcccaa gctgatgatc tacgaggtgt ccaaaaggcc cagcggcgtg      180

cccgataggt ttagcggctc caagtccggc gacacagcct ccctgaccat cagcggcctc      240

caggctgagg atgaggccga ctactactgc agcagccatg ccggcagcaa caacttttac      300

gtgttcggca ccggcacaaa gctgaccgtg ctg                                   333


<210>  126
<211>  333
<212>  DNA
<213>  ˹УArtificial Sequence

<220>
<223>  C2-7BN78K VL 

<400>  126
cagagcgtgc tgattcagcc tcccagcgtg agcggaagcc ctggacagag cgtgaccatc       60

agctgcaccg gcatcagctc cgatgtgggc gcctacgact acgtgagctg gtatcaacag      120

caccctggca aggtgcccaa gctgatgatc tacgaggtgt ccaaaaggcc cagcggcgtg      180

cccgataggt ttagcggctc caagtccggc gacacagcct ccctgaccat cagcggcctc      240

caggctgagg atgaggccga ctactactgc agcagccatg ccggcagcaa caacttttac      300

gtgttcggca ccggcacaaa gctgaccgtg ctg                                   333


<210>  127
<211>  124
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  C2-WT VH

<400>  127

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Val Ser Asp Tyr 
            20                  25                  30          


Tyr Met Asn Trp Ile Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Tyr Ile Ser Ser Ser Ala Ser Gly Ser Thr Ile Tyr Tyr Ala Asp 
    50                  55                  60                  


Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Asn Asn Ser 
65                  70                  75                  80  


Leu Tyr Leu His Met Asp Ser Leu Arg Ala Glu Asp Thr Ala Ile Tyr 
                85                  90                  95      


Phe Cys Ala Arg Val Val Pro Ala Gly Ser Gly Trp Arg Trp Phe Asp 
            100                 105                 110         


Pro Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 


<210>  128
<211>  124
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  C2-4A VH

<400>  128

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Val Ser Asp Tyr 
            20                  25                  30          


Tyr Met Asn Trp Ile Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Tyr Ile Ser Ser Ser Ala Ser Gly Ser Thr Ile Tyr Tyr Ala Asp 
    50                  55                  60                  


Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser 
65                  70                  75                  80  


Leu Tyr Leu His Met Asp Ser Leu Arg Ala Glu Asp Thr Ala Ile Tyr 
                85                  90                  95      


Phe Cys Ala Arg Val Val Pro Ala Gly Ser Gly Trp Arg Trp Phe Asp 
            100                 105                 110         


Pro Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 


<210>  129
<211>  124
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  C2-4B VH

<400>  129

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Val Ser Asp Tyr 
            20                  25                  30          


Tyr Met Asn Trp Phe Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Tyr Ile Ser Ser Ser Ala Ser Gly Ser Thr Ile Tyr Tyr Ala Asp 
    50                  55                  60                  


Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Asn Asn Ser 
65                  70                  75                  80  


Leu Tyr Leu His Met Asp Ser Leu Arg Ala Glu Asp Thr Ala Ile Tyr 
                85                  90                  95      


Phe Cys Ala Arg Val Val Pro Ala Gly Ser Gly Trp Arg Trp Phe Asp 
            100                 105                 110         


Pro Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 


<210>  130
<211>  124
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  C2-4C VH

<400>  130

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Val Ser Asp Tyr 
            20                  25                  30          


Tyr Met Asn Trp Ile Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Tyr Ile Ser Ser Ser Ala Ser Gly Ser Thr Ile Tyr Tyr Ala Asp 
    50                  55                  60                  


Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser 
65                  70                  75                  80  


Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Ile Tyr 
                85                  90                  95      


Phe Cys Ala Arg Val Val Pro Ala Gly Ser Gly Trp Arg Trp Phe Asp 
            100                 105                 110         


Pro Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 


<210>  131
<211>  124
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  C2-5A VH

<400>  131

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Val Ser Asp Tyr 
            20                  25                  30          


Tyr Met Asn Trp Ile Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Tyr Ile Ser Ser Ser Ala Ser Gly Ser Thr Ile Tyr Tyr Ala Asp 
    50                  55                  60                  


Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser 
65                  70                  75                  80  


Leu Tyr Leu His Met Asp Ser Leu Arg Ala Glu Asp Thr Ala Ile Tyr 
                85                  90                  95      


Phe Cys Ala Arg Val Val Pro Ala Gly Ser Gly Trp Arg Trp Phe Asp 
            100                 105                 110         


Pro Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 


<210>  132
<211>  124
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  C2-5B VH

<400>  132

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Val Ser Asp Tyr 
            20                  25                  30          


Tyr Met Asn Trp Ile Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Tyr Ile Ser Ser Ser Ala Ser Gly Ser Thr Ile Tyr Tyr Ala Asp 
    50                  55                  60                  


Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser 
65                  70                  75                  80  


Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Ile Tyr 
                85                  90                  95      


Phe Cys Ala Arg Val Val Pro Ala Gly Ser Gly Trp Arg Trp Phe Asp 
            100                 105                 110         


Pro Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 


<210>  133
<211>  124
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  C2-5C VH

<400>  133

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Val Ser Asp Tyr 
            20                  25                  30          


Tyr Met Asn Trp Phe Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Tyr Ile Ser Ser Ser Ala Ser Gly Ser Thr Ile Tyr Tyr Ala Asp 
    50                  55                  60                  


Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Asn Asn Ser 
65                  70                  75                  80  


Leu Tyr Leu His Met Asp Ser Leu Arg Ala Glu Asp Thr Ala Ile Tyr 
                85                  90                  95      


Tyr Cys Ala Arg Val Val Pro Ala Gly Ser Gly Trp Arg Trp Phe Asp 
            100                 105                 110         


Pro Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 


<210>  134
<211>  124
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  C2-6A VH

<400>  134

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Val Ser Asp Tyr 
            20                  25                  30          


Tyr Met Asn Trp Ile Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Tyr Ile Ser Ser Ser Ala Ser Gly Ser Thr Ile Tyr Tyr Ala Asp 
    50                  55                  60                  


Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser 
65                  70                  75                  80  


Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Ile Tyr 
                85                  90                  95      


Phe Cys Ala Arg Val Val Pro Ala Gly Ser Gly Trp Arg Trp Phe Asp 
            100                 105                 110         


Pro Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 


<210>  135
<211>  124
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  C2-6B VH

<400>  135

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Val Ser Asp Tyr 
            20                  25                  30          


Tyr Met Asn Trp Ile Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Tyr Ile Ser Ser Ser Ala Ser Gly Ser Thr Ile Tyr Tyr Ala Asp 
    50                  55                  60                  


Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser 
65                  70                  75                  80  


Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Ile Tyr 
                85                  90                  95      


Phe Cys Ala Arg Val Val Pro Ala Gly Ser Gly Trp Arg Trp Phe Asp 
            100                 105                 110         


Pro Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 


<210>  136
<211>  124
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  C2-7A VH

<400>  136

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Val Ser Asp Tyr 
            20                  25                  30          


Tyr Met Asn Trp Ile Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Tyr Ile Ser Ser Ser Ala Ser Gly Ser Thr Ile Tyr Tyr Ala Asp 
    50                  55                  60                  


Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser 
65                  70                  75                  80  


Leu Tyr Leu His Met Asp Ser Leu Arg Ala Glu Asp Thr Ala Ile Tyr 
                85                  90                  95      


Phe Cys Ala Arg Val Val Pro Ala Gly Ser Gly Trp Arg Trp Phe Asp 
            100                 105                 110         


Pro Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 


<210>  137
<211>  124
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  C2-7B VH

<400>  137

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Val Ser Asp Tyr 
            20                  25                  30          


Tyr Met Asn Trp Ile Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Tyr Ile Ser Ser Ser Ala Ser Gly Ser Thr Ile Tyr Tyr Ala Asp 
    50                  55                  60                  


Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Asn Asn Ser 
65                  70                  75                  80  


Leu Tyr Leu Gln Met Asn Ser Leu Arg Thr Glu Asp Thr Ala Ile Tyr 
                85                  90                  95      


Tyr Cys Ala Arg Val Val Pro Ala Gly Ser Gly Trp Arg Trp Phe Asp 
            100                 105                 110         


Pro Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 


<210>  138
<211>  124
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  C2-7BN78K VH

<400>  138

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Val Ser Asp Tyr 
            20                  25                  30          


Tyr Met Asn Trp Ile Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Tyr Ile Ser Ser Ser Ala Ser Gly Ser Thr Ile Tyr Tyr Ala Asp 
    50                  55                  60                  


Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser 
65                  70                  75                  80  


Leu Tyr Leu Gln Met Asn Ser Leu Arg Thr Glu Asp Thr Ala Ile Tyr 
                85                  90                  95      


Tyr Cys Ala Arg Val Val Pro Ala Gly Ser Gly Trp Arg Trp Phe Asp 
            100                 105                 110         


Pro Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 


<210>  139
<211>  372
<212>  DNA
<213>  ˹УArtificial Sequence

<220>
<223>  C2-WT VH 

<400>  139
gaggtgcagc tggtggagtc tgggggaggc ttggtacagc ctggagggtc cctgagactc       60

tcctgtgcag cctctggatt caccgtcagt gactactaca tgaactggat ccgccaggct      120

ccagggaagg gcctggagtg ggtttcatac attagtagta gtgctagtgg tagtaccata      180

tactacgcag actctgtgaa gggccgattc accatctcca gggacaacgc caacaactca      240

ctgtatctgc acatggacag cctgagagcc gaggacacgg ccatatactt ctgtgcgaga      300

gtcgtcccag ctggaagtgg gtggaggtgg ttcgacccct ggggccaggg taccctggtc      360

actgtctcct ca                                                          372


<210>  140
<211>  372
<212>  DNA
<213>  ˹УArtificial Sequence

<220>
<223>  C2-4A VH 

<400>  140
gaggtgcagc tggtggagag cggcggcggc ctggtgcagc ccggcggcag cctgaggctg       60

agctgcgccg ccagcggctt caccgtgagc gactactaca tgaactggat caggcaggcc      120

cccggcaagg gcctggagtg ggtgagctac atcagcagca gcgccagcgg cagcaccatc      180

tactacgccg acagcgtgaa gggcaggttc accatcagca gggacaacgc caagaacagc      240

ctgtacctgc acatggacag cctgagggcc gaggacaccg ccatctactt ctgcgccagg      300

gtggtgcccg ccggcagcgg ctggaggtgg ttcgacccct ggggccaggg caccctggtg      360

accgtgagca gc                                                          372


<210>  141
<211>  372
<212>  DNA
<213>  ˹УArtificial Sequence

<220>
<223>  C2-4B VH 

<400>  141
gaggtgcagc tggtggagtc cggcggagga ctggtgcaac ctggcagaag cctgagactg       60

agctgtgccg ccagcggctt caccgtgtcc gactactaca tgaactggtt caggcaggct      120

cccggcaagg gcctggaatg ggtgagctac atcagcagca gcgctagcgg aagcaccatc      180

tactatgccg acagcgtgaa gggcaggttc accatcagca gggacaacgc caacaactcc      240

ctgtacctgc acatggacag cctgagggcc gaagacaccg ccatctactt ctgtgccaga      300

gtggtgcctg ctggctccgg ctggaggtgg ttcgatccct ggggacaggg caccctggtg      360

accgtgagct ct                                                          372


<210>  142
<211>  372
<212>  DNA
<213>  ˹УArtificial Sequence

<220>
<223>  C2-4C VH 

<400>  142
gaggtgcagc tggtggagag cggcggcggc ctggtgcagc ccggcggcag cctgaggctg       60

agctgcgccg ccagcggctt caccgtgagc gactactaca tgaactggat caggcaggcc      120

cccggcaagg gcctggagtg ggtgagctac atcagcagca gcgccagcgg cagcaccatc      180

tactacgccg acagcgtgaa gggcaggttc accatcagca gggacaacgc caagaacagc      240

ctgtacctgc agatgaacag cctgagggcc gaggacaccg ccatctactt ctgcgccagg      300

gtggtgcccg ccggcagcgg ctggaggtgg ttcgacccct ggggccaggg caccctggtg      360

accgtgagca gc                                                          372


<210>  143
<211>  372
<212>  DNA
<213>  ˹УArtificial Sequence

<220>
<223>  C2-5A VH 

<400>  143
gaggtgcagc tggtggagag cggcggcggc ctggtgcagc ccggcaggag cctgaggctg       60

agctgcgccg ccagcggctt caccgtgagc gactactaca tgaactggat caggcaggcc      120

cccggcaagg gcctggagtg ggtgagctac atcagcagca gcgccagcgg cagcaccatc      180

tactacgccg acagcgtgaa gggcaggttc accatcagca gggacaacgc caagaacagc      240

ctgtacctgc acatggacag cctgagggcc gaggacaccg ccatctactt ctgcgccagg      300

gtggtgcccg ccggcagcgg ctggaggtgg ttcgacccct ggggccaggg caccctggtg      360

accgtgagca gc                                                          372


<210>  144
<211>  372
<212>  DNA
<213>  ˹УArtificial Sequence

<220>
<223>  C2-5B VH 

<400>  144
gaggtgcagc tggtggagag cggcggcggc ctggtgcagc ccggcggcag cctgaggctg       60

agctgcgccg ccagcggctt caccgtgagc gactactaca tgaactggat caggcaggcc      120

cccggcaagg gcctggagtg ggtgagctac atcagcagca gcgccagcgg cagcaccatc      180

tactacgccg acagcgtgaa gggcaggttc accatcagca gggacaacgc caagaacagc      240

ctgtacctgc agatgaacag cctgagggcc gaggacaccg ccatctactt ctgcgccagg      300

gtggtgcccg ccggcagcgg ctggaggtgg ttcgacccct ggggccaggg caccctggtg      360

accgtgagca gc                                                          372


<210>  145
<211>  372
<212>  DNA
<213>  ˹УArtificial Sequence

<220>
<223>  C2-5C VH 

<400>  145
gaggtgcagc tggtggagag cggcggcggc ctggtgcagc ccggcaggag cctgaggctg       60

agctgcgccg ccagcggctt caccgtgagc gactactaca tgaactggtt caggcaggcc      120

cccggcaagg gcctggagtg ggtgagctac atcagcagca gcgccagcgg cagcaccatc      180

tactacgccg acagcgtgaa gggcaggttc accatcagca gggacaacgc caacaacagc      240

ctgtacctgc acatggacag cctgagggcc gaggacaccg ccatctacta ctgcgccagg      300

gtggtgcccg ccggcagcgg ctggaggtgg ttcgacccct ggggccaggg caccctggtg      360

accgtgagca gc                                                          372


<210>  146
<211>  372
<212>  DNA
<213>  ˹УArtificial Sequence

<220>
<223>  C2-6A VH 

<400>  146
gaggtgcagc tggtggagag cggcggcggc ctggtgcagc ccggcggcag cctgaggctg       60

agctgcgccg ccagcggctt caccgtgagc gactactaca tgaactggat caggcaggcc      120

cccggcaagg gcctggagtg ggtgagctac atcagcagca gcgccagcgg cagcaccatc      180

tactacgccg acagcgtgaa gggcaggttc accatcagca gggacaacgc caagaacagc      240

ctgtacctgc agatgaacag cctgagggcc gaggacaccg ccatctactt ctgcgccagg      300

gtggtgcccg ccggcagcgg ctggaggtgg ttcgacccct ggggccaggg caccctggtg      360

accgtgagca gc                                                          372


<210>  147
<211>  372
<212>  DNA
<213>  ˹УArtificial Sequence

<220>
<223>  C2-6B VH 

<400>  147
gaggtgcagc tggtggagag cggcggcggc ctggtgaagc ccggcggcag cctgaggctg       60

agctgcgccg ccagcggctt caccgtgagc gactactaca tgaactggat caggcaggcc      120

cccggcaagg gcctggagtg ggtgagctac atcagcagca gcgccagcgg cagcaccatc      180

tactacgccg acagcgtgaa gggcaggttc accatcagca gggacaacgc caagaacagc      240

ctgtacctgc agatgaacag cctgagggcc gaggacaccg ccatctactt ctgcgccagg      300

gtggtgcccg ccggcagcgg ctggaggtgg ttcgacccct ggggccaggg caccctggtg      360

accgtgagca gc                                                          372


<210>  148
<211>  372
<212>  DNA
<213>  ˹УArtificial Sequence

<220>
<223>  C2-7A VH 

<400>  148
gaggtgcagc tggtggaatc tggtggcgga ctggtgaagc ctggcggttc tctgagactg       60

agctgtgccg ccagcggctt caccgtgagc gactactaca tgaactggat caggcaggcc      120

cccggcaaag gcctggaatg ggtgagctac atcagctcct ccgcctctgg ttctaccatc      180

tactacgccg acagcgtgaa gggcaggttc accatcagca gggacaacgc caagaacagc      240

ctctacctgc acatggacag cctgagggcc gaggacaccg ctatctactt ctgcgccaga      300

gtggtgcctg ctggttctgg ctggagatgg ttcgatcctt ggggccaggg caccctggtg      360

acagtgagca gc                                                          372


<210>  149
<211>  372
<212>  DNA
<213>  ˹УArtificial Sequence

<220>
<223>  C2-7B VH 

<400>  149
gaggtgcagc tggtggaaag cggcggcgga ctggtgaagc ctggaggttc tctgaggctg       60

agctgtgccg cctccggctt caccgtgagc gactactaca tgaactggat caggcaggcc      120

cccggcaaag gactggagtg ggtgagctac atctcctcct ccgcctccgg cagcaccatc      180

tactacgccg actccgtgaa gggcaggttc accatctcca gggataacgc caacaacagc      240

ctgtacctgc agatgaactc cctgaggacc gaggacaccg ccatctacta ctgtgccagg      300

gtggtgcccg ctggaagcgg atggaggtgg ttcgacccct ggggccaggg aacactggtg      360

accgtgagca gc                                                          372


<210>  150
<211>  372
<212>  DNA
<213>  ˹УArtificial Sequence

<220>
<223>  C2-7BN78K VH 

<400>  150
gaggtgcagc tggtggaaag cggcggcgga ctggtgaagc ctggaggttc tctgaggctg       60

agctgtgccg cctccggctt caccgtgagc gactactaca tgaactggat caggcaggcc      120

cccggcaaag gactggagtg ggtgagctac atctcctcct ccgcctccgg cagcaccatc      180

tactacgccg actccgtgaa gggcaggttc accatctcca gggataacgc caagaacagc      240

ctgtacctgc agatgaactc cctgaggacc gaggacaccg ccatctacta ctgtgccagg      300

gtggtgcccg ctggaagcgg atggaggtgg ttcgacccct ggggccaggg aacactggtg      360

accgtgagca gc                                                          372


<210>  151
<211>  489
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  C2-WT-Fc

<400>  151

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Val Ser Asp Tyr 
            20                  25                  30          


Tyr Met Asn Trp Ile Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Tyr Ile Ser Ser Ser Ala Ser Gly Ser Thr Ile Tyr Tyr Ala Asp 
    50                  55                  60                  


Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Asn Asn Ser 
65                  70                  75                  80  


Leu Tyr Leu His Met Asp Ser Leu Arg Ala Glu Asp Thr Ala Ile Tyr 
                85                  90                  95      


Phe Cys Ala Arg Val Val Pro Ala Gly Ser Gly Trp Arg Trp Phe Asp 
            100                 105                 110         


Pro Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Ile Leu Gly 
        115                 120                 125             


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
    130                 135                 140                 


Gln Ser Val Leu Ile Gln Pro Pro Ser Ala Ser Gly Ser Pro Gly Gln 
145                 150                 155                 160 


Ser Val Thr Ile Ser Cys Thr Gly Ile Ser Ser Asp Val Gly Ala Tyr 
                165                 170                 175     


Asp Tyr Val Ser Trp Tyr Gln Gln His Pro Gly Lys Val Pro Lys Leu 
            180                 185                 190         


Met Ile Tyr Glu Val Ser Lys Arg Pro Ser Gly Val Pro Asp Arg Phe 
        195                 200                 205             


Ser Gly Ser Lys Ser Gly Asp Thr Ala Ser Leu Thr Val Ser Gly Leu 
    210                 215                 220                 


Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Ser Ser His Ala Gly Ser 
225                 230                 235                 240 


Asn Asn Phe Tyr Val Phe Gly Thr Gly Thr Lys Leu Thr Val Leu Gly 
                245                 250                 255     


Gly Gly Gly Ser Glu Ser Lys Tyr Gly Pro Pro Cys Pro Pro Cys Pro 
            260                 265                 270         


Ala Pro Glu Phe Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys 
        275                 280                 285             


Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val 
    290                 295                 300                 


Val Val Asp Val Ser Gln Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr 
305                 310                 315                 320 


Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu 
                325                 330                 335     


Gln Phe Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His 
            340                 345                 350         


Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys 
        355                 360                 365             


Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln 
    370                 375                 380                 


Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Gln Glu Glu Met 
385                 390                 395                 400 


Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro 
                405                 410                 415     


Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn 
            420                 425                 430         


Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu 
        435                 440                 445             


Tyr Ser Arg Leu Thr Val Asp Lys Ser Arg Trp Gln Glu Gly Asn Val 
    450                 455                 460                 


Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln 
465                 470                 475                 480 


Lys Ser Leu Ser Leu Ser Leu Gly Lys 
                485                 


<210>  152
<211>  484
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  C2-4A-Fc

<400>  152

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Val Ser Asp Tyr 
            20                  25                  30          


Tyr Met Asn Trp Ile Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Tyr Ile Ser Ser Ser Ala Ser Gly Ser Thr Ile Tyr Tyr Ala Asp 
    50                  55                  60                  


Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser 
65                  70                  75                  80  


Leu Tyr Leu His Met Asp Ser Leu Arg Ala Glu Asp Thr Ala Ile Tyr 
                85                  90                  95      


Phe Cys Ala Arg Val Val Pro Ala Gly Ser Gly Trp Arg Trp Phe Asp 
            100                 105                 110         


Pro Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly 
        115                 120                 125             


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Ser Ala Leu Ile 
    130                 135                 140                 


Gln Pro Pro Ser Ala Ser Gly Ser Pro Gly Gln Ser Val Thr Ile Ser 
145                 150                 155                 160 


Cys Thr Gly Ile Ser Ser Asp Val Gly Ala Tyr Asp Tyr Val Ser Trp 
                165                 170                 175     


Tyr Gln Gln His Pro Gly Lys Val Pro Lys Leu Met Ile Tyr Glu Val 
            180                 185                 190         


Ser Lys Arg Pro Ser Gly Val Pro Asp Arg Phe Ser Gly Ser Lys Ser 
        195                 200                 205             


Gly Asn Thr Ala Ser Leu Thr Ile Ser Gly Leu Gln Ala Glu Asp Glu 
    210                 215                 220                 


Ala Asp Tyr Tyr Cys Ser Ser His Ala Gly Ser Asn Asn Phe Tyr Val 
225                 230                 235                 240 


Phe Gly Thr Gly Thr Lys Leu Thr Val Leu Gly Gly Gly Gly Ser Glu 
                245                 250                 255     


Ser Lys Tyr Gly Pro Pro Cys Pro Pro Cys Pro Ala Pro Glu Phe Leu 
            260                 265                 270         


Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu 
        275                 280                 285             


Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser 
    290                 295                 300                 


Gln Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu 
305                 310                 315                 320 


Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr 
                325                 330                 335     


Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn 
            340                 345                 350         


Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu Pro Ser Ser 
        355                 360                 365             


Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln 
    370                 375                 380                 


Val Tyr Thr Leu Pro Pro Ser Gln Glu Glu Met Thr Lys Asn Gln Val 
385                 390                 395                 400 


Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val 
                405                 410                 415     


Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro 
            420                 425                 430         


Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Arg Leu Thr 
        435                 440                 445             


Val Asp Lys Ser Arg Trp Gln Glu Gly Asn Val Phe Ser Cys Ser Val 
    450                 455                 460                 


Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu 
465                 470                 475                 480 


Ser Leu Gly Lys 
                


<210>  153
<211>  484
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  C2-4B-Fc

<400>  153

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Val Ser Asp Tyr 
            20                  25                  30          


Tyr Met Asn Trp Phe Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Tyr Ile Ser Ser Ser Ala Ser Gly Ser Thr Ile Tyr Tyr Ala Asp 
    50                  55                  60                  


Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Asn Asn Ser 
65                  70                  75                  80  


Leu Tyr Leu His Met Asp Ser Leu Arg Ala Glu Asp Thr Ala Ile Tyr 
                85                  90                  95      


Phe Cys Ala Arg Val Val Pro Ala Gly Ser Gly Trp Arg Trp Phe Asp 
            100                 105                 110         


Pro Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly 
        115                 120                 125             


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Ser Val Leu Ile 
    130                 135                 140                 


Gln Pro Pro Ser Val Ser Gly Ser Pro Gly Gln Ser Val Thr Ile Ser 
145                 150                 155                 160 


Cys Thr Gly Ile Ser Ser Asp Val Gly Ala Tyr Asp Tyr Val Ser Trp 
                165                 170                 175     


Tyr Gln Gln His Pro Gly Lys Val Pro Lys Leu Met Ile Tyr Glu Val 
            180                 185                 190         


Ser Lys Arg Pro Ser Gly Val Pro Asp Arg Phe Ser Gly Ser Lys Ser 
        195                 200                 205             


Gly Asp Thr Ala Ser Leu Thr Ile Ser Gly Leu Gln Ala Glu Asp Glu 
    210                 215                 220                 


Ala Asp Tyr Tyr Cys Ser Ser His Ala Gly Ser Asn Asn Phe Tyr Val 
225                 230                 235                 240 


Phe Gly Thr Gly Thr Lys Leu Thr Val Leu Gly Gly Gly Gly Ser Glu 
                245                 250                 255     


Ser Lys Tyr Gly Pro Pro Cys Pro Pro Cys Pro Ala Pro Glu Phe Leu 
            260                 265                 270         


Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu 
        275                 280                 285             


Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser 
    290                 295                 300                 


Gln Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu 
305                 310                 315                 320 


Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr 
                325                 330                 335     


Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn 
            340                 345                 350         


Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu Pro Ser Ser 
        355                 360                 365             


Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln 
    370                 375                 380                 


Val Tyr Thr Leu Pro Pro Ser Gln Glu Glu Met Thr Lys Asn Gln Val 
385                 390                 395                 400 


Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val 
                405                 410                 415     


Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro 
            420                 425                 430         


Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Arg Leu Thr 
        435                 440                 445             


Val Asp Lys Ser Arg Trp Gln Glu Gly Asn Val Phe Ser Cys Ser Val 
    450                 455                 460                 


Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu 
465                 470                 475                 480 


Ser Leu Gly Lys 
                


<210>  154
<211>  484
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  C2-4C-Fc

<400>  154

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Val Ser Asp Tyr 
            20                  25                  30          


Tyr Met Asn Trp Ile Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Tyr Ile Ser Ser Ser Ala Ser Gly Ser Thr Ile Tyr Tyr Ala Asp 
    50                  55                  60                  


Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser 
65                  70                  75                  80  


Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Ile Tyr 
                85                  90                  95      


Phe Cys Ala Arg Val Val Pro Ala Gly Ser Gly Trp Arg Trp Phe Asp 
            100                 105                 110         


Pro Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly 
        115                 120                 125             


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Ser Val Leu Ile 
    130                 135                 140                 


Gln Pro Pro Ser Ala Ser Gly Ser Pro Gly Gln Ser Val Thr Ile Ser 
145                 150                 155                 160 


Cys Thr Gly Ile Ser Ser Asp Val Gly Ala Tyr Asp Tyr Val Ser Trp 
                165                 170                 175     


Tyr Gln Gln His Pro Gly Lys Val Pro Lys Leu Met Ile Tyr Glu Val 
            180                 185                 190         


Ser Lys Arg Pro Ser Gly Val Pro Asp Arg Phe Ser Gly Ser Lys Ser 
        195                 200                 205             


Gly Asn Thr Ala Ser Leu Thr Val Ser Gly Leu Gln Ala Glu Asp Glu 
    210                 215                 220                 


Ala Asp Tyr Tyr Cys Ser Ser His Ala Gly Ser Asn Asn Phe Tyr Val 
225                 230                 235                 240 


Phe Gly Thr Gly Thr Lys Leu Thr Val Leu Gly Gly Gly Gly Ser Glu 
                245                 250                 255     


Ser Lys Tyr Gly Pro Pro Cys Pro Pro Cys Pro Ala Pro Glu Phe Leu 
            260                 265                 270         


Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu 
        275                 280                 285             


Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser 
    290                 295                 300                 


Gln Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu 
305                 310                 315                 320 


Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr 
                325                 330                 335     


Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn 
            340                 345                 350         


Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu Pro Ser Ser 
        355                 360                 365             


Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln 
    370                 375                 380                 


Val Tyr Thr Leu Pro Pro Ser Gln Glu Glu Met Thr Lys Asn Gln Val 
385                 390                 395                 400 


Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val 
                405                 410                 415     


Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro 
            420                 425                 430         


Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Arg Leu Thr 
        435                 440                 445             


Val Asp Lys Ser Arg Trp Gln Glu Gly Asn Val Phe Ser Cys Ser Val 
    450                 455                 460                 


Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu 
465                 470                 475                 480 


Ser Leu Gly Lys 
                


<210>  155
<211>  484
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  C2-5A-Fc

<400>  155

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Val Ser Asp Tyr 
            20                  25                  30          


Tyr Met Asn Trp Ile Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Tyr Ile Ser Ser Ser Ala Ser Gly Ser Thr Ile Tyr Tyr Ala Asp 
    50                  55                  60                  


Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser 
65                  70                  75                  80  


Leu Tyr Leu His Met Asp Ser Leu Arg Ala Glu Asp Thr Ala Ile Tyr 
                85                  90                  95      


Phe Cys Ala Arg Val Val Pro Ala Gly Ser Gly Trp Arg Trp Phe Asp 
            100                 105                 110         


Pro Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly 
        115                 120                 125             


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Ser Val Leu Ile 
    130                 135                 140                 


Gln Pro Pro Ser Val Ser Gly Ser Pro Gly Gln Ser Val Thr Ile Ser 
145                 150                 155                 160 


Cys Thr Gly Ile Ser Ser Asp Val Gly Ala Tyr Asp Tyr Val Ser Trp 
                165                 170                 175     


Tyr Gln Gln His Pro Gly Lys Val Pro Lys Leu Met Ile Tyr Glu Val 
            180                 185                 190         


Ser Lys Arg Pro Ser Gly Val Pro Asp Arg Phe Ser Gly Ser Lys Ser 
        195                 200                 205             


Gly Asn Thr Ala Ser Leu Thr Ile Ser Gly Leu Gln Ala Glu Asp Glu 
    210                 215                 220                 


Ala Asp Tyr Tyr Cys Ser Ser His Ala Gly Ser Asn Asn Phe Tyr Val 
225                 230                 235                 240 


Phe Gly Thr Gly Thr Lys Leu Thr Val Leu Gly Gly Gly Gly Ser Glu 
                245                 250                 255     


Ser Lys Tyr Gly Pro Pro Cys Pro Pro Cys Pro Ala Pro Glu Phe Leu 
            260                 265                 270         


Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu 
        275                 280                 285             


Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser 
    290                 295                 300                 


Gln Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu 
305                 310                 315                 320 


Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr 
                325                 330                 335     


Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn 
            340                 345                 350         


Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu Pro Ser Ser 
        355                 360                 365             


Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln 
    370                 375                 380                 


Val Tyr Thr Leu Pro Pro Ser Gln Glu Glu Met Thr Lys Asn Gln Val 
385                 390                 395                 400 


Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val 
                405                 410                 415     


Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro 
            420                 425                 430         


Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Arg Leu Thr 
        435                 440                 445             


Val Asp Lys Ser Arg Trp Gln Glu Gly Asn Val Phe Ser Cys Ser Val 
    450                 455                 460                 


Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu 
465                 470                 475                 480 


Ser Leu Gly Lys 
                


<210>  156
<211>  484
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  C2-5B-Fc

<400>  156

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Val Ser Asp Tyr 
            20                  25                  30          


Tyr Met Asn Trp Ile Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Tyr Ile Ser Ser Ser Ala Ser Gly Ser Thr Ile Tyr Tyr Ala Asp 
    50                  55                  60                  


Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser 
65                  70                  75                  80  


Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Ile Tyr 
                85                  90                  95      


Phe Cys Ala Arg Val Val Pro Ala Gly Ser Gly Trp Arg Trp Phe Asp 
            100                 105                 110         


Pro Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly 
        115                 120                 125             


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Ser Val Leu Ile 
    130                 135                 140                 


Gln Pro Pro Ser Ala Ser Gly Ser Pro Gly Gln Ser Val Thr Ile Ser 
145                 150                 155                 160 


Cys Thr Gly Ile Ser Ser Asp Val Gly Ala Tyr Asp Tyr Val Ser Trp 
                165                 170                 175     


Tyr Gln Gln His Pro Gly Lys Val Pro Lys Leu Met Ile Tyr Glu Val 
            180                 185                 190         


Ser Lys Arg Pro Ser Gly Val Pro Asp Arg Phe Ser Gly Ser Lys Ser 
        195                 200                 205             


Gly Asn Thr Ala Ser Leu Thr Ile Ser Gly Leu Gln Ala Glu Asp Glu 
    210                 215                 220                 


Ala Asp Tyr Tyr Cys Ser Ser His Ala Gly Ser Asn Asn Phe Tyr Val 
225                 230                 235                 240 


Phe Gly Thr Gly Thr Lys Leu Thr Val Leu Gly Gly Gly Gly Ser Glu 
                245                 250                 255     


Ser Lys Tyr Gly Pro Pro Cys Pro Pro Cys Pro Ala Pro Glu Phe Leu 
            260                 265                 270         


Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu 
        275                 280                 285             


Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser 
    290                 295                 300                 


Gln Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu 
305                 310                 315                 320 


Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr 
                325                 330                 335     


Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn 
            340                 345                 350         


Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu Pro Ser Ser 
        355                 360                 365             


Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln 
    370                 375                 380                 


Val Tyr Thr Leu Pro Pro Ser Gln Glu Glu Met Thr Lys Asn Gln Val 
385                 390                 395                 400 


Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val 
                405                 410                 415     


Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro 
            420                 425                 430         


Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Arg Leu Thr 
        435                 440                 445             


Val Asp Lys Ser Arg Trp Gln Glu Gly Asn Val Phe Ser Cys Ser Val 
    450                 455                 460                 


Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu 
465                 470                 475                 480 


Ser Leu Gly Lys 
                


<210>  157
<211>  484
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  C2-5C-Fc

<400>  157

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Val Ser Asp Tyr 
            20                  25                  30          


Tyr Met Asn Trp Phe Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Tyr Ile Ser Ser Ser Ala Ser Gly Ser Thr Ile Tyr Tyr Ala Asp 
    50                  55                  60                  


Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Asn Asn Ser 
65                  70                  75                  80  


Leu Tyr Leu His Met Asp Ser Leu Arg Ala Glu Asp Thr Ala Ile Tyr 
                85                  90                  95      


Tyr Cys Ala Arg Val Val Pro Ala Gly Ser Gly Trp Arg Trp Phe Asp 
            100                 105                 110         


Pro Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly 
        115                 120                 125             


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Ser Val Leu Ile 
    130                 135                 140                 


Gln Pro Pro Ser Val Ser Gly Ser Pro Gly Gln Ser Val Thr Ile Ser 
145                 150                 155                 160 


Cys Thr Gly Ile Ser Ser Asp Val Gly Ala Tyr Asp Tyr Val Ser Trp 
                165                 170                 175     


Tyr Gln Gln His Pro Gly Lys Val Pro Lys Leu Met Ile Tyr Glu Val 
            180                 185                 190         


Ser Lys Arg Pro Ser Gly Val Pro Asp Arg Phe Ser Gly Ser Lys Ser 
        195                 200                 205             


Gly Asp Thr Ala Ser Leu Thr Ile Ser Gly Leu Gln Ala Glu Asp Glu 
    210                 215                 220                 


Ala Asp Tyr Tyr Cys Ser Ser His Ala Gly Ser Asn Asn Phe Tyr Val 
225                 230                 235                 240 


Phe Gly Thr Gly Thr Lys Leu Thr Val Leu Gly Gly Gly Gly Ser Glu 
                245                 250                 255     


Ser Lys Tyr Gly Pro Pro Cys Pro Pro Cys Pro Ala Pro Glu Phe Leu 
            260                 265                 270         


Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu 
        275                 280                 285             


Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser 
    290                 295                 300                 


Gln Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu 
305                 310                 315                 320 


Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr 
                325                 330                 335     


Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn 
            340                 345                 350         


Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu Pro Ser Ser 
        355                 360                 365             


Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln 
    370                 375                 380                 


Val Tyr Thr Leu Pro Pro Ser Gln Glu Glu Met Thr Lys Asn Gln Val 
385                 390                 395                 400 


Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val 
                405                 410                 415     


Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro 
            420                 425                 430         


Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Arg Leu Thr 
        435                 440                 445             


Val Asp Lys Ser Arg Trp Gln Glu Gly Asn Val Phe Ser Cys Ser Val 
    450                 455                 460                 


Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu 
465                 470                 475                 480 


Ser Leu Gly Lys 
                


<210>  158
<211>  484
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  C2-6A-Fc

<400>  158

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Val Ser Asp Tyr 
            20                  25                  30          


Tyr Met Asn Trp Ile Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Tyr Ile Ser Ser Ser Ala Ser Gly Ser Thr Ile Tyr Tyr Ala Asp 
    50                  55                  60                  


Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser 
65                  70                  75                  80  


Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Ile Tyr 
                85                  90                  95      


Phe Cys Ala Arg Val Val Pro Ala Gly Ser Gly Trp Arg Trp Phe Asp 
            100                 105                 110         


Pro Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly 
        115                 120                 125             


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Ser Val Leu Ile 
    130                 135                 140                 


Gln Pro Pro Ser Val Ser Gly Ser Pro Gly Gln Ser Val Thr Ile Ser 
145                 150                 155                 160 


Cys Thr Gly Ile Ser Ser Asp Val Gly Ala Tyr Asp Tyr Val Ser Trp 
                165                 170                 175     


Tyr Gln Gln His Pro Gly Lys Val Pro Lys Leu Met Ile Tyr Glu Val 
            180                 185                 190         


Ser Lys Arg Pro Ser Gly Val Pro Asp Arg Phe Ser Gly Ser Lys Ser 
        195                 200                 205             


Gly Asn Thr Ala Ser Leu Thr Ile Ser Gly Leu Gln Ala Glu Asp Glu 
    210                 215                 220                 


Ala Asp Tyr Tyr Cys Ser Ser His Ala Gly Ser Asn Asn Phe Tyr Val 
225                 230                 235                 240 


Phe Gly Thr Gly Thr Lys Leu Thr Val Leu Gly Gly Gly Gly Ser Glu 
                245                 250                 255     


Ser Lys Tyr Gly Pro Pro Cys Pro Pro Cys Pro Ala Pro Glu Phe Leu 
            260                 265                 270         


Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu 
        275                 280                 285             


Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser 
    290                 295                 300                 


Gln Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu 
305                 310                 315                 320 


Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr 
                325                 330                 335     


Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn 
            340                 345                 350         


Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu Pro Ser Ser 
        355                 360                 365             


Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln 
    370                 375                 380                 


Val Tyr Thr Leu Pro Pro Ser Gln Glu Glu Met Thr Lys Asn Gln Val 
385                 390                 395                 400 


Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val 
                405                 410                 415     


Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro 
            420                 425                 430         


Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Arg Leu Thr 
        435                 440                 445             


Val Asp Lys Ser Arg Trp Gln Glu Gly Asn Val Phe Ser Cys Ser Val 
    450                 455                 460                 


Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu 
465                 470                 475                 480 


Ser Leu Gly Lys 
                


<210>  159
<211>  484
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  C2-6B-Fc

<400>  159

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Val Ser Asp Tyr 
            20                  25                  30          


Tyr Met Asn Trp Ile Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Tyr Ile Ser Ser Ser Ala Ser Gly Ser Thr Ile Tyr Tyr Ala Asp 
    50                  55                  60                  


Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser 
65                  70                  75                  80  


Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Ile Tyr 
                85                  90                  95      


Phe Cys Ala Arg Val Val Pro Ala Gly Ser Gly Trp Arg Trp Phe Asp 
            100                 105                 110         


Pro Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly 
        115                 120                 125             


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Ser Val Leu Ile 
    130                 135                 140                 


Gln Pro Pro Ser Val Ser Gly Ser Pro Gly Gln Ser Val Thr Ile Ser 
145                 150                 155                 160 


Cys Thr Gly Ile Ser Ser Asp Val Gly Ala Tyr Asp Tyr Val Ser Trp 
                165                 170                 175     


Tyr Gln Gln His Pro Gly Lys Val Pro Lys Leu Met Ile Tyr Glu Val 
            180                 185                 190         


Ser Lys Arg Pro Ser Gly Val Pro Asp Arg Phe Ser Gly Ser Lys Ser 
        195                 200                 205             


Gly Asn Thr Ala Ser Leu Thr Val Ser Gly Leu Gln Ala Glu Asp Glu 
    210                 215                 220                 


Ala Asp Tyr Tyr Cys Ser Ser His Ala Gly Ser Asn Asn Phe Tyr Val 
225                 230                 235                 240 


Phe Gly Thr Gly Thr Lys Leu Thr Val Leu Gly Gly Gly Gly Ser Glu 
                245                 250                 255     


Ser Lys Tyr Gly Pro Pro Cys Pro Pro Cys Pro Ala Pro Glu Phe Leu 
            260                 265                 270         


Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu 
        275                 280                 285             


Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser 
    290                 295                 300                 


Gln Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu 
305                 310                 315                 320 


Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr 
                325                 330                 335     


Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn 
            340                 345                 350         


Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu Pro Ser Ser 
        355                 360                 365             


Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln 
    370                 375                 380                 


Val Tyr Thr Leu Pro Pro Ser Gln Glu Glu Met Thr Lys Asn Gln Val 
385                 390                 395                 400 


Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val 
                405                 410                 415     


Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro 
            420                 425                 430         


Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Arg Leu Thr 
        435                 440                 445             


Val Asp Lys Ser Arg Trp Gln Glu Gly Asn Val Phe Ser Cys Ser Val 
    450                 455                 460                 


Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu 
465                 470                 475                 480 


Ser Leu Gly Lys 
                


<210>  160
<211>  484
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  C2-7A-Fc

<400>  160

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Val Ser Asp Tyr 
            20                  25                  30          


Tyr Met Asn Trp Ile Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Tyr Ile Ser Ser Ser Ala Ser Gly Ser Thr Ile Tyr Tyr Ala Asp 
    50                  55                  60                  


Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser 
65                  70                  75                  80  


Leu Tyr Leu His Met Asp Ser Leu Arg Ala Glu Asp Thr Ala Ile Tyr 
                85                  90                  95      


Phe Cys Ala Arg Val Val Pro Ala Gly Ser Gly Trp Arg Trp Phe Asp 
            100                 105                 110         


Pro Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly 
        115                 120                 125             


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Ser Ala Leu Ile 
    130                 135                 140                 


Gln Pro Pro Ser Val Ser Gly Ser Pro Gly Gln Ser Val Thr Ile Ser 
145                 150                 155                 160 


Cys Thr Gly Ile Ser Ser Asp Val Gly Ala Tyr Asp Tyr Val Ser Trp 
                165                 170                 175     


Tyr Gln Gln His Pro Gly Thr Val Pro Lys Leu Met Ile Tyr Glu Val 
            180                 185                 190         


Ser Lys Arg Pro Ser Gly Val Pro Asp Arg Phe Ser Gly Ser Lys Ser 
        195                 200                 205             


Gly Asn Thr Ala Ser Leu Thr Ile Ser Gly Leu Gln Ala Glu Asp Glu 
    210                 215                 220                 


Ala Asp Tyr Tyr Cys Ser Ser His Ala Gly Ser Asn Asn Phe Tyr Val 
225                 230                 235                 240 


Phe Gly Thr Gly Thr Lys Leu Thr Val Leu Gly Gly Gly Gly Ser Glu 
                245                 250                 255     


Ser Lys Tyr Gly Pro Pro Cys Pro Pro Cys Pro Ala Pro Glu Phe Leu 
            260                 265                 270         


Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu 
        275                 280                 285             


Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser 
    290                 295                 300                 


Gln Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu 
305                 310                 315                 320 


Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr 
                325                 330                 335     


Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn 
            340                 345                 350         


Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu Pro Ser Ser 
        355                 360                 365             


Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln 
    370                 375                 380                 


Val Tyr Thr Leu Pro Pro Ser Gln Glu Glu Met Thr Lys Asn Gln Val 
385                 390                 395                 400 


Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val 
                405                 410                 415     


Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro 
            420                 425                 430         


Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Arg Leu Thr 
        435                 440                 445             


Val Asp Lys Ser Arg Trp Gln Glu Gly Asn Val Phe Ser Cys Ser Val 
    450                 455                 460                 


Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu 
465                 470                 475                 480 


Ser Leu Gly Lys 
                


<210>  161
<211>  484
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  C2-7B-Fc

<400>  161

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Val Ser Asp Tyr 
            20                  25                  30          


Tyr Met Asn Trp Ile Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Tyr Ile Ser Ser Ser Ala Ser Gly Ser Thr Ile Tyr Tyr Ala Asp 
    50                  55                  60                  


Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Asn Asn Ser 
65                  70                  75                  80  


Leu Tyr Leu Gln Met Asn Ser Leu Arg Thr Glu Asp Thr Ala Ile Tyr 
                85                  90                  95      


Tyr Cys Ala Arg Val Val Pro Ala Gly Ser Gly Trp Arg Trp Phe Asp 
            100                 105                 110         


Pro Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly 
        115                 120                 125             


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Ser Val Leu Ile 
    130                 135                 140                 


Gln Pro Pro Ser Val Ser Gly Ser Pro Gly Gln Ser Val Thr Ile Ser 
145                 150                 155                 160 


Cys Thr Gly Ile Ser Ser Asp Val Gly Ala Tyr Asp Tyr Val Ser Trp 
                165                 170                 175     


Tyr Gln Gln His Pro Gly Lys Val Pro Lys Leu Met Ile Tyr Glu Val 
            180                 185                 190         


Ser Lys Arg Pro Ser Gly Val Pro Asp Arg Phe Ser Gly Ser Lys Ser 
        195                 200                 205             


Gly Asp Thr Ala Ser Leu Thr Ile Ser Gly Leu Gln Ala Glu Asp Glu 
    210                 215                 220                 


Ala Asp Tyr Tyr Cys Ser Ser His Ala Gly Ser Asn Asn Phe Tyr Val 
225                 230                 235                 240 


Phe Gly Thr Gly Thr Lys Leu Thr Val Leu Gly Gly Gly Gly Ser Glu 
                245                 250                 255     


Ser Lys Tyr Gly Pro Pro Cys Pro Pro Cys Pro Ala Pro Glu Phe Leu 
            260                 265                 270         


Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu 
        275                 280                 285             


Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser 
    290                 295                 300                 


Gln Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu 
305                 310                 315                 320 


Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr 
                325                 330                 335     


Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn 
            340                 345                 350         


Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu Pro Ser Ser 
        355                 360                 365             


Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln 
    370                 375                 380                 


Val Tyr Thr Leu Pro Pro Ser Gln Glu Glu Met Thr Lys Asn Gln Val 
385                 390                 395                 400 


Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val 
                405                 410                 415     


Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro 
            420                 425                 430         


Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Arg Leu Thr 
        435                 440                 445             


Val Asp Lys Ser Arg Trp Gln Glu Gly Asn Val Phe Ser Cys Ser Val 
    450                 455                 460                 


Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu 
465                 470                 475                 480 


Ser Leu Gly Lys 
                


<210>  162
<211>  484
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  C2-7BN78K-Fc

<400>  162

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Val Ser Asp Tyr 
            20                  25                  30          


Tyr Met Asn Trp Ile Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Tyr Ile Ser Ser Ser Ala Ser Gly Ser Thr Ile Tyr Tyr Ala Asp 
    50                  55                  60                  


Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser 
65                  70                  75                  80  


Leu Tyr Leu Gln Met Asn Ser Leu Arg Thr Glu Asp Thr Ala Ile Tyr 
                85                  90                  95      


Tyr Cys Ala Arg Val Val Pro Ala Gly Ser Gly Trp Arg Trp Phe Asp 
            100                 105                 110         


Pro Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly 
        115                 120                 125             


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Ser Val Leu Ile 
    130                 135                 140                 


Gln Pro Pro Ser Val Ser Gly Ser Pro Gly Gln Ser Val Thr Ile Ser 
145                 150                 155                 160 


Cys Thr Gly Ile Ser Ser Asp Val Gly Ala Tyr Asp Tyr Val Ser Trp 
                165                 170                 175     


Tyr Gln Gln His Pro Gly Lys Val Pro Lys Leu Met Ile Tyr Glu Val 
            180                 185                 190         


Ser Lys Arg Pro Ser Gly Val Pro Asp Arg Phe Ser Gly Ser Lys Ser 
        195                 200                 205             


Gly Asp Thr Ala Ser Leu Thr Ile Ser Gly Leu Gln Ala Glu Asp Glu 
    210                 215                 220                 


Ala Asp Tyr Tyr Cys Ser Ser His Ala Gly Ser Asn Asn Phe Tyr Val 
225                 230                 235                 240 


Phe Gly Thr Gly Thr Lys Leu Thr Val Leu Gly Gly Gly Gly Ser Glu 
                245                 250                 255     


Ser Lys Tyr Gly Pro Pro Cys Pro Pro Cys Pro Ala Pro Glu Phe Leu 
            260                 265                 270         


Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu 
        275                 280                 285             


Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser 
    290                 295                 300                 


Gln Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu 
305                 310                 315                 320 


Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr 
                325                 330                 335     


Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn 
            340                 345                 350         


Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu Pro Ser Ser 
        355                 360                 365             


Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln 
    370                 375                 380                 


Val Tyr Thr Leu Pro Pro Ser Gln Glu Glu Met Thr Lys Asn Gln Val 
385                 390                 395                 400 


Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val 
                405                 410                 415     


Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro 
            420                 425                 430         


Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Arg Leu Thr 
        435                 440                 445             


Val Asp Lys Ser Arg Trp Gln Glu Gly Asn Val Phe Ser Cys Ser Val 
    450                 455                 460                 


Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu 
465                 470                 475                 480 


Ser Leu Gly Lys 
                


<210>  163
<211>  229
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  Fc

<400>  163

Glu Ser Lys Tyr Gly Pro Pro Cys Pro Pro Cys Pro Ala Pro Glu Phe 
1               5                   10                  15      


Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr 
            20                  25                  30          


Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val 
        35                  40                  45              


Ser Gln Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp Gly Val 
    50                  55                  60                  


Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser 
65                  70                  75                  80  


Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu 
                85                  90                  95      


Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu Pro Ser 
            100                 105                 110         


Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro 
        115                 120                 125             


Gln Val Tyr Thr Leu Pro Pro Ser Gln Glu Glu Met Thr Lys Asn Gln 
    130                 135                 140                 


Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala 
145                 150                 155                 160 


Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr 
                165                 170                 175     


Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Arg Leu 
            180                 185                 190         


Thr Val Asp Lys Ser Arg Trp Gln Glu Gly Asn Val Phe Ser Cys Ser 
        195                 200                 205             


Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser 
    210                 215                 220                 


Leu Ser Leu Gly Lys 
225                 


<210>  164
<211>  229
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  Fc-WT

<400>  164

Glu Ser Lys Tyr Gly Pro Pro Cys Pro Ser Cys Pro Ala Pro Glu Phe 
1               5                   10                  15      


Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr 
            20                  25                  30          


Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val 
        35                  40                  45              


Ser Gln Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp Gly Val 
    50                  55                  60                  


Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser 
65                  70                  75                  80  


Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu 
                85                  90                  95      


Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu Pro Ser 
            100                 105                 110         


Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro 
        115                 120                 125             


Gln Val Tyr Thr Leu Pro Pro Ser Gln Glu Glu Met Thr Lys Asn Gln 
    130                 135                 140                 


Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala 
145                 150                 155                 160 


Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr 
                165                 170                 175     


Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Arg Leu 
            180                 185                 190         


Thr Val Asp Lys Ser Arg Trp Gln Glu Gly Asn Val Phe Ser Cys Ser 
        195                 200                 205             


Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser 
    210                 215                 220                 


Leu Ser Leu Gly Lys 
225                 


<210>  165
<211>  15
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  (G4S)3

<400>  165

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
1               5                   10                  15  


<210>  166
<211>  5
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  G4S

<400>  166

Gly Gly Gly Gly Ser 
1               5   


