                         SEQUENCE LISTING

<110>  Universitt Heidelberg
 
<120>  Novel means to modulate NMDA receptor -mediated toxicity

<130>  FMP-001 PCT

<160>  58    

<170>  PatentIn version 3.5

<210>  1
<211>  1214
<212>  PRT
<213>  Homo sapiens

<400>  1

Met Val Val Pro Glu Lys Glu Gln Ser Trp Ile Pro Lys Ile Phe Lys 
1               5                   10                  15      


Lys Lys Thr Cys Thr Thr Phe Ile Val Asp Ser Thr Asp Pro Gly Gly 
            20                  25                  30          


Thr Leu Cys Gln Cys Gly Arg Pro Arg Thr Ala His Pro Ala Val Ala 
        35                  40                  45              


Met Glu Asp Ala Phe Gly Ala Ala Val Val Thr Val Trp Asp Ser Asp 
    50                  55                  60                  


Ala His Thr Thr Glu Lys Pro Thr Asp Ala Tyr Gly Glu Leu Asp Phe 
65                  70                  75                  80  


Thr Gly Ala Gly Arg Lys His Ser Asn Phe Leu Arg Leu Ser Asp Arg 
                85                  90                  95      


Thr Asp Pro Ala Ala Val Tyr Ser Leu Val Thr Arg Thr Trp Gly Phe 
            100                 105                 110         


Arg Ala Pro Asn Leu Val Val Ser Val Leu Gly Gly Ser Gly Gly Pro 
        115                 120                 125             


Val Leu Gln Thr Trp Leu Gln Asp Leu Leu Arg Arg Gly Leu Val Arg 
    130                 135                 140                 


Ala Ala Gln Ser Thr Gly Ala Trp Ile Val Thr Gly Gly Leu His Thr 
145                 150                 155                 160 


Gly Ile Gly Arg His Val Gly Val Ala Val Arg Asp His Gln Met Ala 
                165                 170                 175     


Ser Thr Gly Gly Thr Lys Val Val Ala Met Gly Val Ala Pro Trp Gly 
            180                 185                 190         


Val Val Arg Asn Arg Asp Thr Leu Ile Asn Pro Lys Gly Ser Phe Pro 
        195                 200                 205             


Ala Arg Tyr Arg Trp Arg Gly Asp Pro Glu Asp Gly Val Gln Phe Pro 
    210                 215                 220                 


Leu Asp Tyr Asn Tyr Ser Ala Phe Phe Leu Val Asp Asp Gly Thr His 
225                 230                 235                 240 


Gly Cys Leu Gly Gly Glu Asn Arg Phe Arg Leu Arg Leu Glu Ser Tyr 
                245                 250                 255     


Ile Ser Gln Gln Lys Thr Gly Val Gly Gly Thr Gly Ile Asp Ile Pro 
            260                 265                 270         


Val Leu Leu Leu Leu Ile Asp Gly Asp Glu Lys Met Leu Thr Arg Ile 
        275                 280                 285             


Glu Asn Ala Thr Gln Ala Gln Leu Pro Cys Leu Leu Val Ala Gly Ser 
    290                 295                 300                 


Gly Gly Ala Ala Asp Cys Leu Ala Glu Thr Leu Glu Asp Thr Leu Ala 
305                 310                 315                 320 


Pro Gly Ser Gly Gly Ala Arg Gln Gly Glu Ala Arg Asp Arg Ile Arg 
                325                 330                 335     


Arg Phe Phe Pro Lys Gly Asp Leu Glu Val Leu Gln Ala Gln Val Glu 
            340                 345                 350         


Arg Ile Met Thr Arg Lys Glu Leu Leu Thr Val Tyr Ser Ser Glu Asp 
        355                 360                 365             


Gly Ser Glu Glu Phe Glu Thr Ile Val Leu Lys Ala Leu Val Lys Ala 
    370                 375                 380                 


Cys Gly Ser Ser Glu Ala Ser Ala Tyr Leu Asp Glu Leu Arg Leu Ala 
385                 390                 395                 400 


Val Ala Trp Asn Arg Val Asp Ile Ala Gln Ser Glu Leu Phe Arg Gly 
                405                 410                 415     


Asp Ile Gln Trp Arg Ser Phe His Leu Glu Ala Ser Leu Met Asp Ala 
            420                 425                 430         


Leu Leu Asn Asp Arg Pro Glu Phe Val Arg Leu Leu Ile Ser His Gly 
        435                 440                 445             


Leu Ser Leu Gly His Phe Leu Thr Pro Met Arg Leu Ala Gln Leu Tyr 
    450                 455                 460                 


Ser Ala Ala Pro Ser Asn Ser Leu Ile Arg Asn Leu Leu Asp Gln Ala 
465                 470                 475                 480 


Ser His Ser Ala Gly Thr Lys Ala Pro Ala Leu Lys Gly Gly Ala Ala 
                485                 490                 495     


Glu Leu Arg Pro Pro Asp Val Gly His Val Leu Arg Met Leu Leu Gly 
            500                 505                 510         


Lys Met Cys Ala Pro Arg Tyr Pro Ser Gly Gly Ala Trp Asp Pro His 
        515                 520                 525             


Pro Gly Gln Gly Phe Gly Glu Ser Met Tyr Leu Leu Ser Asp Lys Ala 
    530                 535                 540                 


Thr Ser Pro Leu Ser Leu Asp Ala Gly Leu Gly Gln Ala Pro Trp Ser 
545                 550                 555                 560 


Asp Leu Leu Leu Trp Ala Leu Leu Leu Asn Arg Ala Gln Met Ala Met 
                565                 570                 575     


Tyr Phe Trp Glu Met Gly Ser Asn Ala Val Ser Ser Ala Leu Gly Ala 
            580                 585                 590         


Cys Leu Leu Leu Arg Val Met Ala Arg Leu Glu Pro Asp Ala Glu Glu 
        595                 600                 605             


Ala Ala Arg Arg Lys Asp Leu Ala Phe Lys Phe Glu Gly Met Gly Val 
    610                 615                 620                 


Asp Leu Phe Gly Glu Cys Tyr Arg Ser Ser Glu Val Arg Ala Ala Arg 
625                 630                 635                 640 


Leu Leu Leu Arg Arg Cys Pro Leu Trp Gly Asp Ala Thr Cys Leu Gln 
                645                 650                 655     


Leu Ala Met Gln Ala Asp Ala Arg Ala Phe Phe Ala Gln Asp Gly Val 
            660                 665                 670         


Gln Ser Leu Leu Thr Gln Lys Trp Trp Gly Asp Met Ala Ser Thr Thr 
        675                 680                 685             


Pro Ile Trp Ala Leu Val Leu Ala Phe Phe Cys Pro Pro Leu Ile Tyr 
    690                 695                 700                 


Thr Arg Leu Ile Thr Phe Arg Lys Ser Glu Glu Glu Pro Thr Arg Glu 
705                 710                 715                 720 


Glu Leu Glu Phe Asp Met Asp Ser Val Ile Asn Gly Glu Gly Pro Val 
                725                 730                 735     


Gly Thr Ala Asp Pro Ala Glu Lys Thr Pro Leu Gly Val Pro Arg Gln 
            740                 745                 750         


Ser Gly Arg Pro Gly Cys Cys Gly Gly Arg Cys Gly Gly Arg Arg Cys 
        755                 760                 765             


Leu Arg Arg Trp Phe His Phe Trp Gly Ala Pro Val Thr Ile Phe Met 
    770                 775                 780                 


Gly Asn Val Val Ser Tyr Leu Leu Phe Leu Leu Leu Phe Ser Arg Val 
785                 790                 795                 800 


Leu Leu Val Asp Phe Gln Pro Ala Pro Pro Gly Ser Leu Glu Leu Leu 
                805                 810                 815     


Leu Tyr Phe Trp Ala Phe Thr Leu Leu Cys Glu Glu Leu Arg Gln Gly 
            820                 825                 830         


Leu Ser Gly Gly Gly Gly Ser Leu Ala Ser Gly Gly Pro Gly Pro Gly 
        835                 840                 845             


His Ala Ser Leu Ser Gln Arg Leu Arg Leu Tyr Leu Ala Asp Ser Trp 
    850                 855                 860                 


Asn Gln Cys Asp Leu Val Ala Leu Thr Cys Phe Leu Leu Gly Val Gly 
865                 870                 875                 880 


Cys Arg Leu Thr Pro Gly Leu Tyr His Leu Gly Arg Thr Val Leu Cys 
                885                 890                 895     


Ile Asp Phe Met Val Phe Thr Val Arg Leu Leu His Ile Phe Thr Val 
            900                 905                 910         


Asn Lys Gln Leu Gly Pro Lys Ile Val Ile Val Ser Lys Met Met Lys 
        915                 920                 925             


Asp Val Phe Phe Phe Leu Phe Phe Leu Gly Val Trp Leu Val Ala Tyr 
    930                 935                 940                 


Gly Val Ala Thr Glu Gly Leu Leu Arg Pro Arg Asp Ser Asp Phe Pro 
945                 950                 955                 960 


Ser Ile Leu Arg Arg Val Phe Tyr Arg Pro Tyr Leu Gln Ile Phe Gly 
                965                 970                 975     


Gln Ile Pro Gln Glu Asp Met Asp Val Ala Leu Met Glu His Ser Asn 
            980                 985                 990         


Cys Ser Ser Glu Pro Gly Phe Trp  Ala His Pro Pro Gly  Ala Gln Ala 
        995                 1000                 1005             


Gly Thr  Cys Val Ser Gln Tyr  Ala Asn Trp Leu Val  Val Leu Leu 
    1010                 1015                 1020             


Leu Val  Ile Phe Leu Leu Val  Ala Asn Ile Leu Leu  Val Asn Leu 
    1025                 1030                 1035             


Leu Ile  Ala Met Phe Ser Tyr  Thr Phe Gly Lys Val  Gln Gly Asn 
    1040                 1045                 1050             


Ser Asp  Leu Tyr Trp Lys Ala  Gln Arg Tyr Arg Leu  Ile Arg Glu 
    1055                 1060                 1065             


Phe His  Ser Arg Pro Ala Leu  Ala Pro Pro Phe Ile  Val Ile Ser 
    1070                 1075                 1080             


His Leu  Arg Leu Leu Leu Arg  Gln Leu Cys Arg Arg  Pro Arg Ser 
    1085                 1090                 1095             


Pro Gln  Pro Ser Ser Pro Ala  Leu Glu His Phe Arg  Val Tyr Leu 
    1100                 1105                 1110             


Ser Lys  Glu Ala Glu Arg Lys  Leu Leu Thr Trp Glu  Ser Val His 
    1115                 1120                 1125             


Lys Glu  Asn Phe Leu Leu Ala  Arg Ala Arg Asp Lys  Arg Glu Ser 
    1130                 1135                 1140             


Asp Ser  Glu Arg Leu Lys Arg  Thr Ser Gln Lys Val  Asp Leu Ala 
    1145                 1150                 1155             


Leu Lys  Gln Leu Gly His Ile  Arg Glu Tyr Glu Gln  Arg Leu Lys 
    1160                 1165                 1170             


Val Leu  Glu Arg Glu Val Gln  Gln Cys Ser Arg Val  Leu Gly Trp 
    1175                 1180                 1185             


Val Ala  Glu Ala Leu Ser Arg  Ser Ala Leu Leu Pro  Pro Gly Gly 
    1190                 1195                 1200             


Pro Pro  Pro Pro Asp Leu Pro  Gly Ser Lys Asp 
    1205                 1210                 


<210>  2
<211>  1069
<212>  PRT
<213>  Homo sapiens

<400>  2

Met Val Val Pro Glu Lys Glu Gln Ser Trp Ile Pro Lys Ile Phe Lys 
1               5                   10                  15      


Lys Lys Thr Cys Thr Thr Phe Ile Val Asp Ser Thr Asp Pro Gly Gly 
            20                  25                  30          


Thr Leu Cys Gln Cys Gly Arg Pro Arg Thr Ala His Pro Ala Val Ala 
        35                  40                  45              


Met Glu Asp Ala Phe Gly Ala Ala Val Val Thr Val Trp Asp Ser Asp 
    50                  55                  60                  


Ala His Thr Thr Glu Lys Pro Thr Asp Ala Tyr Gly Glu Leu Asp Phe 
65                  70                  75                  80  


Thr Gly Ala Gly Arg Lys His Ser Asn Phe Leu Arg Leu Ser Asp Arg 
                85                  90                  95      


Thr Asp Pro Ala Ala Val Tyr Ser Leu Val Thr Arg Thr Trp Gly Phe 
            100                 105                 110         


Arg Ala Pro Asn Leu Val Val Ser Val Leu Gly Gly Ser Gly Gly Pro 
        115                 120                 125             


Val Leu Gln Thr Trp Leu Gln Asp Leu Leu Arg Arg Gly Leu Val Arg 
    130                 135                 140                 


Ala Ala Gln Ser Thr Gly Ala Trp Ile Val Thr Gly Gly Leu His Thr 
145                 150                 155                 160 


Gly Ile Gly Arg His Val Gly Val Ala Val Arg Asp His Gln Met Ala 
                165                 170                 175     


Ser Thr Gly Gly Thr Lys Val Val Ala Met Gly Val Ala Pro Trp Gly 
            180                 185                 190         


Val Val Arg Asn Arg Asp Thr Leu Ile Asn Pro Lys Gly Ser Phe Pro 
        195                 200                 205             


Ala Arg Tyr Arg Trp Arg Gly Asp Pro Glu Asp Gly Val Gln Phe Pro 
    210                 215                 220                 


Leu Asp Tyr Asn Tyr Ser Ala Phe Phe Leu Val Asp Asp Gly Thr His 
225                 230                 235                 240 


Gly Cys Leu Gly Gly Glu Asn Arg Phe Arg Leu Arg Leu Glu Ser Tyr 
                245                 250                 255     


Ile Ser Gln Gln Lys Thr Gly Val Gly Gly Thr Gly Ile Asp Ile Pro 
            260                 265                 270         


Val Leu Leu Leu Leu Ile Asp Gly Asp Glu Lys Met Leu Thr Arg Ile 
        275                 280                 285             


Glu Asn Ala Thr Gln Ala Gln Leu Pro Cys Leu Leu Val Ala Gly Ser 
    290                 295                 300                 


Gly Gly Ala Ala Asp Cys Leu Ala Glu Thr Leu Glu Asp Thr Leu Ala 
305                 310                 315                 320 


Pro Gly Ser Gly Gly Ala Arg Gln Gly Glu Ala Arg Asp Arg Ile Arg 
                325                 330                 335     


Arg Phe Phe Pro Lys Gly Asp Leu Glu Val Leu Gln Ala Gln Val Glu 
            340                 345                 350         


Arg Ile Met Thr Arg Lys Glu Leu Leu Thr Val Tyr Ser Ser Glu Asp 
        355                 360                 365             


Gly Ser Glu Glu Phe Glu Thr Ile Val Leu Lys Ala Leu Val Lys Ala 
    370                 375                 380                 


Cys Gly Ser Ser Glu Ala Ser Ala Tyr Leu Asp Glu Leu Arg Leu Ala 
385                 390                 395                 400 


Val Ala Trp Asn Arg Val Asp Ile Ala Gln Ser Glu Leu Phe Arg Gly 
                405                 410                 415     


Asp Ile Gln Trp Arg Ser Phe His Leu Glu Ala Ser Leu Met Asp Ala 
            420                 425                 430         


Leu Leu Asn Asp Arg Pro Glu Phe Val Arg Leu Leu Ile Ser His Gly 
        435                 440                 445             


Leu Ser Leu Gly His Phe Leu Thr Pro Met Arg Leu Ala Gln Leu Tyr 
    450                 455                 460                 


Ser Ala Ala Pro Ser Asn Ser Leu Ile Arg Asn Leu Leu Asp Gln Ala 
465                 470                 475                 480 


Ser His Ser Ala Gly Thr Lys Ala Pro Ala Leu Lys Gly Gly Ala Ala 
                485                 490                 495     


Glu Leu Arg Pro Pro Asp Val Gly His Val Leu Arg Met Leu Leu Gly 
            500                 505                 510         


Lys Met Cys Ala Pro Arg Tyr Pro Ser Gly Gly Ala Trp Asp Pro His 
        515                 520                 525             


Pro Gly Gln Gly Phe Gly Glu Ser Met Tyr Leu Leu Ser Asp Lys Ala 
    530                 535                 540                 


Thr Ser Pro Leu Ser Leu Asp Ala Gly Leu Gly Gln Ala Pro Trp Ser 
545                 550                 555                 560 


Asp Leu Leu Leu Trp Ala Leu Leu Leu Asn Arg Ala Gln Met Ala Met 
                565                 570                 575     


Tyr Phe Trp Glu Met Gly Ser Asn Ala Val Ser Ser Ala Leu Gly Ala 
            580                 585                 590         


Cys Leu Leu Leu Arg Val Met Ala Arg Leu Glu Pro Asp Ala Glu Glu 
        595                 600                 605             


Ala Ala Arg Arg Lys Asp Leu Ala Phe Lys Phe Glu Gly Met Gly Val 
    610                 615                 620                 


Asp Leu Phe Gly Glu Cys Tyr Arg Ser Ser Glu Val Arg Ala Ala Arg 
625                 630                 635                 640 


Leu Leu Leu Arg Arg Cys Pro Leu Trp Gly Asp Ala Thr Cys Leu Gln 
                645                 650                 655     


Leu Ala Met Gln Ala Asp Ala Arg Ala Phe Phe Ala Gln Asp Gly Val 
            660                 665                 670         


Gln Ser Leu Leu Thr Gln Lys Trp Trp Gly Asp Met Ala Ser Thr Thr 
        675                 680                 685             


Pro Ile Trp Ala Leu Val Leu Ala Phe Phe Cys Pro Pro Leu Ile Tyr 
    690                 695                 700                 


Thr Arg Leu Ile Thr Phe Arg Lys Ser Glu Glu Glu Pro Thr Arg Glu 
705                 710                 715                 720 


Glu Leu Glu Phe Asp Met Asp Ser Val Ile Asn Gly Glu Gly Pro Val 
                725                 730                 735     


Gly Leu Thr Pro Gly Leu Tyr His Leu Gly Arg Thr Val Leu Cys Ile 
            740                 745                 750         


Asp Phe Met Val Phe Thr Val Arg Leu Leu His Ile Phe Thr Val Asn 
        755                 760                 765             


Lys Gln Leu Gly Pro Lys Ile Val Ile Val Ser Lys Met Met Lys Asp 
    770                 775                 780                 


Val Phe Phe Phe Leu Phe Phe Leu Gly Val Trp Leu Val Ala Tyr Gly 
785                 790                 795                 800 


Val Ala Thr Glu Gly Leu Leu Arg Pro Arg Asp Ser Asp Phe Pro Ser 
                805                 810                 815     


Ile Leu Arg Arg Val Phe Tyr Arg Pro Tyr Leu Gln Ile Phe Gly Gln 
            820                 825                 830         


Ile Pro Gln Glu Asp Met Asp Val Ala Leu Met Glu His Ser Asn Cys 
        835                 840                 845             


Ser Ser Glu Pro Gly Phe Trp Ala His Pro Pro Gly Ala Gln Ala Gly 
    850                 855                 860                 


Thr Cys Val Ser Gln Tyr Ala Asn Trp Leu Val Val Leu Leu Leu Val 
865                 870                 875                 880 


Ile Phe Leu Leu Val Ala Asn Ile Leu Leu Val Asn Leu Leu Ile Ala 
                885                 890                 895     


Met Phe Ser Tyr Thr Phe Gly Lys Val Gln Gly Asn Ser Asp Leu Tyr 
            900                 905                 910         


Trp Lys Ala Gln Arg Tyr Arg Leu Ile Arg Glu Phe His Ser Arg Pro 
        915                 920                 925             


Ala Leu Ala Pro Pro Phe Ile Val Ile Ser His Leu Arg Leu Leu Leu 
    930                 935                 940                 


Arg Gln Leu Cys Arg Arg Pro Arg Ser Pro Gln Pro Ser Ser Pro Ala 
945                 950                 955                 960 


Leu Glu His Phe Arg Val Tyr Leu Ser Lys Glu Ala Glu Arg Lys Leu 
                965                 970                 975     


Leu Thr Trp Glu Ser Val His Lys Glu Asn Phe Leu Leu Ala Arg Ala 
            980                 985                 990         


Arg Asp Lys Arg Glu Ser Asp Ser  Glu Arg Leu Lys Arg  Thr Ser Gln 
        995                 1000                 1005             


Lys Val  Asp Leu Ala Leu Lys  Gln Leu Gly His Ile  Arg Glu Tyr 
    1010                 1015                 1020             


Glu Gln  Arg Leu Lys Val Leu  Glu Arg Glu Val Gln  Gln Cys Ser 
    1025                 1030                 1035             


Arg Val  Leu Gly Trp Val Ala  Glu Ala Leu Ser Arg  Ser Ala Leu 
    1040                 1045                 1050             


Leu Pro  Pro Gly Gly Pro Pro  Pro Pro Asp Leu Pro  Gly Ser Lys 
    1055                 1060                 1065             


Asp 
    


<210>  3
<211>  57
<212>  PRT
<213>  Homo sapiens

<400>  3

Ser Ser Glu Val Arg Ala Ala Arg Leu Leu Leu Arg Arg Cys Pro Leu 
1               5                   10                  15      


Trp Gly Asp Ala Thr Cys Leu Gln Leu Ala Met Gln Ala Asp Ala Arg 
            20                  25                  30          


Ala Phe Phe Ala Gln Asp Gly Val Gln Ser Leu Leu Thr Gln Lys Trp 
        35                  40                  45              


Trp Gly Asp Met Ala Ser Thr Thr Pro 
    50                  55          


<210>  4
<211>  57
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Consensus sequence on basis of SEQ ID NOs 3 and 5 to 41


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  Xaa can be Asn or Ser

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa can be Asn or Ser

<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  Xaa can be Asp, Glu, Tyr, Lys, His, Thr, Val or Asn

<220>
<221>  MISC_FEATURE
<222>  (5)..(5)
<223>  Xaa can be Arg or Trp

<220>
<221>  MISC_FEATURE
<222>  (6)..(6)
<223>  Xaa can be Ala or Ser

<220>
<221>  MISC_FEATURE
<222>  (7)..(7)
<223>  Xaa can be Ala, Ser or Asn

<220>
<221>  MISC_FEATURE
<222>  (8)..(8)
<223>  Xaa can be Arg, Gly or His

<220>
<221>  MISC_FEATURE
<222>  (11)..(11)
<223>  Xaa can be Leu, Val or Ile

<220>
<221>  MISC_FEATURE
<222>  (12)..(12)
<223>  Xaa can be Arg or Trp

<220>
<221>  MISC_FEATURE
<222>  (16)..(16)
<223>  Xaa can be Leu or Phe

<220>
<221>  MISC_FEATURE
<222>  (19)..(19)
<223>  Xaa can be Asp, Glu or Gly

<220>
<221>  MISC_FEATURE
<222>  (20)..(20)
<223>  Xaa can be Ala or Ser

<220>
<221>  MISC_FEATURE
<222>  (23)..(23)
<223>  Xaa can be Leu or Phe

<220>
<221>  MISC_FEATURE
<222>  (24)..(24)
<223>  Xaa can be Gln or His

<220>
<221>  MISC_FEATURE
<222>  (27)..(27)
<223>  Xaa can be Met or Thr

<220>
<221>  MISC_FEATURE
<222>  (31)..(31)
<223>  Xaa can be Ala or Ser

<220>
<221>  MISC_FEATURE
<222>  (33)..(33)
<223>  Xaa can be Ala or Ser

<220>
<221>  MISC_FEATURE
<222>  (35)..(35)
<223>  Xaa can be Leu or Phe

<220>
<221>  MISC_FEATURE
<222>  (40)..(40)
<223>  Xaa can be Val or Ile

<220>
<221>  MISC_FEATURE
<222>  (42)..(42)
<223>  Xaa can be Ser or Phe

<220>
<221>  MISC_FEATURE
<222>  (43)..(43)
<223>  Xaa can be Leu or Val

<220>
<221>  MISC_FEATURE
<222>  (51)..(51)
<223>  Xaa can be Asp, Glu or His

<220>
<221>  MISC_FEATURE
<222>  (53)..(53)
<223>  Xaa can be Ala or Asp

<220>
<221>  MISC_FEATURE
<222>  (55)..(55)
<223>  Xaa can be Thr or Ser

<220>
<221>  MISC_FEATURE
<222>  (56)..(56)
<223>  Xaa can be Thr or Asn

<400>  4

Xaa Xaa Glu Xaa Xaa Xaa Xaa Xaa Leu Leu Xaa Xaa Arg Cys Pro Xaa 
1               5                   10                  15      


Trp Gly Xaa Xaa Thr Cys Xaa Xaa Leu Ala Xaa Gln Ala Asp Xaa Arg 
            20                  25                  30          


Xaa Phe Xaa Ala Gln Asp Gly Xaa Gln Xaa Xaa Leu Thr Gln Lys Trp 
        35                  40                  45              


Trp Gly Xaa Met Xaa Ser Xaa Xaa Pro 
    50                  55          


<210>  5
<211>  57
<212>  PRT
<213>  Mus musculus

<400>  5

Asn Ser Glu Glu Arg Ala Ala Arg Leu Leu Leu Arg Arg Cys Pro Leu 
1               5                   10                  15      


Trp Gly Glu Ala Thr Cys Leu Gln Leu Ala Met Gln Ala Asp Ala Arg 
            20                  25                  30          


Ala Phe Phe Ala Gln Asp Gly Val Gln Ser Leu Leu Thr Gln Lys Trp 
        35                  40                  45              


Trp Gly Glu Met Asp Ser Thr Thr Pro 
    50                  55          


<210>  6
<211>  57
<212>  PRT
<213>  Peromyscus maniculatus

<400>  6

Asn Ser Glu Glu Arg Ala Ala Arg Leu Leu Leu Arg Arg Cys Pro Leu 
1               5                   10                  15      


Trp Gly Glu Ala Thr Cys Leu Gln Leu Ala Met Gln Ala Asp Ala Arg 
            20                  25                  30          


Ala Phe Phe Ala Gln Asp Gly Val Gln Ser Leu Leu Thr Gln Lys Trp 
        35                  40                  45              


Trp Gly Glu Met Asp Ser Thr Thr Pro 
    50                  55          


<210>  7
<211>  57
<212>  PRT
<213>  Mus caroli

<400>  7

Asn Ser Glu Asp Arg Ala Ala Arg Leu Leu Leu Arg Arg Cys Pro Leu 
1               5                   10                  15      


Trp Gly Glu Ala Thr Cys Leu Gln Leu Ala Met Gln Ala Asp Ala Arg 
            20                  25                  30          


Ala Phe Phe Ala Gln Asp Gly Val Gln Ser Leu Leu Thr Gln Lys Trp 
        35                  40                  45              


Trp Gly Glu Met Asp Ser Thr Thr Pro 
    50                  55          


<210>  8
<211>  57
<212>  PRT
<213>  Cricetulus griseus

<400>  8

Asn Ser Glu Glu Arg Ala Ala Arg Leu Leu Leu Arg Arg Cys Pro Leu 
1               5                   10                  15      


Trp Gly Glu Ala Thr Cys Leu Gln Leu Ala Met Gln Ala Asp Ala Arg 
            20                  25                  30          


Ser Phe Phe Ala Gln Asp Gly Val Gln Ser Leu Leu Thr Gln Lys Trp 
        35                  40                  45              


Trp Gly Asp Met Asp Ser Thr Thr Pro 
    50                  55          


<210>  9
<211>  57
<212>  PRT
<213>  Jaculus jaculus

<400>  9

Asn Asn Glu Asp Arg Ala Ala Arg Leu Leu Leu Arg Arg Cys Pro Leu 
1               5                   10                  15      


Trp Gly Glu Ala Thr Cys Leu Gln Leu Ala Met Gln Ala Asp Ala Arg 
            20                  25                  30          


Ala Phe Phe Ala Gln Asp Gly Val Gln Ser Leu Leu Thr Gln Lys Trp 
        35                  40                  45              


Trp Gly Glu Met Asp Ser Thr Thr Pro 
    50                  55          


<210>  10
<211>  57
<212>  PRT
<213>  Canis lupus familiaris

<400>  10

Ser Ser Glu Glu Arg Ala Ala Arg Leu Leu Leu Arg Arg Cys Pro Leu 
1               5                   10                  15      


Trp Gly Asp Ala Thr Cys Leu Gln Leu Ala Met Gln Ala Asp Ala Arg 
            20                  25                  30          


Ala Phe Phe Ala Gln Asp Gly Val Gln Ser Leu Leu Thr Gln Lys Trp 
        35                  40                  45              


Trp Gly Glu Met Asp Ser Thr Thr Pro 
    50                  55          


<210>  11
<211>  57
<212>  PRT
<213>  Hipposideros armiger

<400>  11

Asn Ser Glu Asp Arg Ala Ala Arg Leu Leu Leu Arg Arg Cys Pro Phe 
1               5                   10                  15      


Trp Gly Asp Ala Thr Cys Leu Gln Leu Ala Met Gln Ala Asp Ala Arg 
            20                  25                  30          


Ala Phe Phe Ala Gln Asp Gly Val Gln Ser Leu Leu Thr Gln Lys Trp 
        35                  40                  45              


Trp Gly Glu Met Asp Ser Thr Thr Pro 
    50                  55          


<210>  12
<211>  57
<212>  PRT
<213>  Rattus norvegicus

<400>  12

Asn Ser Glu Tyr Arg Ala Ala Arg Leu Leu Leu Arg Arg Cys Pro Leu 
1               5                   10                  15      


Trp Gly Glu Ala Thr Cys Leu Gln Leu Ala Met Gln Ala Asp Ala Arg 
            20                  25                  30          


Ala Phe Phe Ala Gln Asp Gly Val Gln Ser Leu Leu Thr Gln Lys Trp 
        35                  40                  45              


Trp Gly Glu Met Asp Ser Thr Asn Pro 
    50                  55          


<210>  13
<211>  57
<212>  PRT
<213>  Acinonyx jubatus

<400>  13

Ser Ser Glu Lys Arg Ala Ala Arg Leu Leu Leu Arg Arg Cys Pro Leu 
1               5                   10                  15      


Trp Gly Asp Ala Thr Cys Leu Gln Leu Ala Met Gln Ala Asp Ala Arg 
            20                  25                  30          


Ala Phe Phe Ala Gln Asp Gly Val Gln Ser Leu Leu Thr Gln Lys Trp 
        35                  40                  45              


Trp Gly Glu Met Asp Ser Thr Thr Pro 
    50                  55          


<210>  14
<211>  57
<212>  PRT
<213>  Odobenus rosmarus divergens

<400>  14

Ser Ser Glu Glu Arg Ala Ala Arg Leu Leu Val Arg Arg Cys Pro Leu 
1               5                   10                  15      


Trp Gly Asp Ala Thr Cys Leu Gln Leu Ala Met Gln Ala Asp Ala Arg 
            20                  25                  30          


Ala Phe Phe Ala Gln Asp Gly Val Gln Ser Leu Leu Thr Gln Lys Trp 
        35                  40                  45              


Trp Gly Glu Met Asp Ser Thr Thr Pro 
    50                  55          


<210>  15
<211>  57
<212>  PRT
<213>  Neomonachus schauinslandi

<400>  15

Ser Ser Glu Glu Arg Ala Ala Arg Leu Leu Val Arg Arg Cys Pro Leu 
1               5                   10                  15      


Trp Gly Asp Ala Thr Cys Leu Gln Leu Ala Met Gln Ala Asp Ala Arg 
            20                  25                  30          


Ala Phe Phe Ala Gln Asp Gly Val Gln Ser Leu Leu Thr Gln Lys Trp 
        35                  40                  45              


Trp Gly Glu Met Asp Ser Thr Thr Pro 
    50                  55          


<210>  16
<211>  57
<212>  PRT
<213>  Manis javanica

<400>  16

Ser Ser Glu His Arg Ala Ala Arg Leu Leu Ile Arg Arg Cys Pro Leu 
1               5                   10                  15      


Trp Gly Asp Ala Thr Cys Leu Gln Leu Ala Met Gln Ala Asp Ala Arg 
            20                  25                  30          


Ala Phe Phe Ala Gln Asp Gly Val Gln Ser Leu Leu Thr Gln Lys Trp 
        35                  40                  45              


Trp Gly Glu Met Asp Ser Thr Thr Pro 
    50                  55          


<210>  17
<211>  57
<212>  PRT
<213>  Marmota marmota marmota

<400>  17

Ser Ser Glu Asp Arg Ala Ala Arg Leu Leu Leu Arg Arg Cys Pro Leu 
1               5                   10                  15      


Trp Gly Asp Ala Thr Cys Leu Gln Leu Ala Met Gln Ala Asp Ala Arg 
            20                  25                  30          


Ala Phe Phe Ala Gln Asp Gly Val Gln Ser Leu Leu Thr Gln Lys Trp 
        35                  40                  45              


Trp Gly Glu Met Asp Ser Thr Thr Pro 
    50                  55          


<210>  18
<211>  57
<212>  PRT
<213>  Enhydra lutris kenyoni

<400>  18

Ser Ser Glu Lys Arg Ala Ala Arg Leu Leu Leu Arg Arg Cys Pro Leu 
1               5                   10                  15      


Trp Gly Asp Ala Thr Cys Leu Gln Leu Ala Met Gln Ala Asp Ala Arg 
            20                  25                  30          


Ala Phe Phe Ala Gln Asp Gly Val Gln Ser Leu Leu Thr Gln Lys Trp 
        35                  40                  45              


Trp Gly Glu Met Asp Ser Thr Thr Pro 
    50                  55          


<210>  19
<211>  57
<212>  PRT
<213>  Ictidomys tridecemlineatus

<400>  19

Ser Ser Glu Asp Arg Ala Ala Arg Leu Leu Leu Arg Arg Cys Pro Leu 
1               5                   10                  15      


Trp Gly Asp Ala Thr Cys Leu Gln Leu Ala Met Gln Ala Asp Ala Arg 
            20                  25                  30          


Ala Phe Phe Ala Gln Asp Gly Val Gln Ser Leu Leu Thr Gln Lys Trp 
        35                  40                  45              


Trp Gly Glu Met Asp Ser Thr Thr Pro 
    50                  55          


<210>  20
<211>  57
<212>  PRT
<213>  Felis catus

<400>  20

Ser Ser Glu Lys Arg Ala Ala Arg Leu Leu Leu Arg Arg Cys Pro Leu 
1               5                   10                  15      


Trp Gly Asp Ala Thr Cys Leu Gln Leu Ala Met Gln Ala Asp Ala Arg 
            20                  25                  30          


Ala Phe Phe Ala Gln Asp Gly Val Gln Ser Leu Leu Thr Gln Lys Trp 
        35                  40                  45              


Trp Gly Glu Met Asp Ser Thr Thr Pro 
    50                  55          


<210>  21
<211>  57
<212>  PRT
<213>  Heterocephalus glaber

<400>  21

Ser Ser Glu Glu Arg Ala Ser Arg Leu Leu Leu Arg Arg Cys Pro Leu 
1               5                   10                  15      


Trp Gly Asp Ala Thr Cys Leu Gln Leu Ala Met Gln Ala Asp Ala Arg 
            20                  25                  30          


Ala Phe Phe Ala Gln Asp Gly Val Gln Ser Leu Leu Thr Gln Lys Trp 
        35                  40                  45              


Trp Gly Glu Met Asp Ser Thr Thr Pro 
    50                  55          


<210>  22
<211>  57
<212>  PRT
<213>  Capra hircus

<400>  22

Ser Ser Glu Glu Arg Ser Ala Arg Leu Leu Leu Arg Arg Cys Pro Leu 
1               5                   10                  15      


Trp Gly Asp Ala Thr Cys Leu Gln Leu Ala Thr Gln Ala Asp Ala Arg 
            20                  25                  30          


Ala Phe Phe Ala Gln Asp Gly Val Gln Ser Leu Leu Thr Gln Lys Trp 
        35                  40                  45              


Trp Gly Glu Met Asp Ser Thr Thr Pro 
    50                  55          


<210>  23
<211>  57
<212>  PRT
<213>  Equus asinus

<400>  23

Ser Ser Glu Glu Arg Ala Ser Arg Leu Leu Leu Arg Arg Cys Pro Leu 
1               5                   10                  15      


Trp Gly Asp Ala Thr Cys Phe Gln Leu Ala Met Gln Ala Asp Ala Arg 
            20                  25                  30          


Ala Phe Phe Ala Gln Asp Gly Ile Gln Ser Leu Leu Thr Gln Lys Trp 
        35                  40                  45              


Trp Gly Glu Met Asp Ser Thr Thr Pro 
    50                  55          


<210>  24
<211>  57
<212>  PRT
<213>  Rhinolophus sinicus

<400>  24

Asn Ser Glu Asp Arg Ala Ala Arg Leu Leu Leu Arg Arg Cys Pro Phe 
1               5                   10                  15      


Trp Gly Asp Ala Thr Cys Phe Gln Leu Ala Met Gln Ala Asp Ala Arg 
            20                  25                  30          


Ala Phe Phe Ala Gln Asp Gly Val Gln Ser Leu Leu Thr Gln Lys Trp 
        35                  40                  45              


Trp Gly Glu Met Asp Ser Ser Thr Pro 
    50                  55          


<210>  25
<211>  57
<212>  PRT
<213>  Ovis aries

<400>  25

Ser Ser Glu Glu Arg Ser Ala Arg Leu Leu Leu Arg Arg Cys Pro Leu 
1               5                   10                  15      


Trp Gly Asp Ala Thr Cys Leu Gln Leu Ala Thr Gln Ala Asp Ala Arg 
            20                  25                  30          


Ala Phe Phe Ala Gln Asp Gly Val Gln Ser Leu Leu Thr Gln Lys Trp 
        35                  40                  45              


Trp Gly Glu Met Asp Ser Thr Thr Pro 
    50                  55          


<210>  26
<211>  57
<212>  PRT
<213>  Mesocricetus auratus

<400>  26

Asn Ser Glu Glu Arg Ala Ala Gly Leu Leu Leu Arg Arg Cys Pro Leu 
1               5                   10                  15      


Trp Gly Glu Ala Thr Cys Leu Gln Leu Ala Met Gln Ala Asp Ala Arg 
            20                  25                  30          


Ser Phe Phe Ala Gln Asp Gly Val Gln Phe Leu Leu Thr Gln Lys Trp 
        35                  40                  45              


Trp Gly Glu Met Asp Ser Thr Thr Pro 
    50                  55          


<210>  27
<211>  57
<212>  PRT
<213>  Bison bison bison

<400>  27

Ser Ser Glu Glu Arg Ser Ala Arg Leu Leu Leu Arg Arg Cys Pro Leu 
1               5                   10                  15      


Trp Gly Asp Ala Thr Cys Leu Gln Leu Ala Thr Gln Ala Asp Ala Arg 
            20                  25                  30          


Ala Phe Phe Ala Gln Asp Gly Val Gln Ser Leu Leu Thr Gln Lys Trp 
        35                  40                  45              


Trp Gly Glu Met Asp Ser Thr Thr Pro 
    50                  55          


<210>  28
<211>  57
<212>  PRT
<213>  Bos taurus

<400>  28

Ser Ser Glu Glu Arg Ser Ala Arg Leu Leu Leu Arg Arg Cys Pro Leu 
1               5                   10                  15      


Trp Gly Asp Ala Thr Cys Leu Gln Leu Ala Thr Gln Ala Asp Ala Arg 
            20                  25                  30          


Ala Phe Phe Ala Gln Asp Gly Val Gln Ser Leu Leu Thr Gln Lys Trp 
        35                  40                  45              


Trp Gly Glu Met Asp Ser Thr Thr Pro 
    50                  55          


<210>  29
<211>  57
<212>  PRT
<213>  Bubalus bubalis

<400>  29

Ser Ser Glu Glu Arg Ser Ala Arg Leu Leu Leu Arg Arg Cys Pro Leu 
1               5                   10                  15      


Trp Gly Asp Ala Thr Cys Leu Gln Leu Ala Thr Gln Ala Asp Ala Arg 
            20                  25                  30          


Ala Phe Phe Ala Gln Asp Gly Val Gln Ser Leu Leu Thr Gln Lys Trp 
        35                  40                  45              


Trp Gly Glu Met Asp Ser Thr Thr Pro 
    50                  55          


<210>  30
<211>  57
<212>  PRT
<213>  Erinaceus europaeus

<400>  30

Ser Ser Glu Asp Arg Ala Asn Arg Leu Leu Leu Arg Arg Cys Pro Leu 
1               5                   10                  15      


Trp Gly Asp Ala Thr Cys Leu Gln Leu Ala Met Gln Ala Asp Ala Arg 
            20                  25                  30          


Ala Phe Phe Ala Gln Asp Gly Val Gln Ser Leu Leu Thr Gln Lys Trp 
        35                  40                  45              


Trp Gly Glu Met Asp Ser Thr Thr Pro 
    50                  55          


<210>  31
<211>  57
<212>  PRT
<213>  Cavia porcellus

<400>  31

Ser Asn Glu His Arg Ala Ser Arg Leu Leu Leu Arg Arg Cys Pro Leu 
1               5                   10                  15      


Trp Gly Asp Ala Thr Cys Leu Gln Leu Ala Met Gln Ala Asp Ser Arg 
            20                  25                  30          


Ala Phe Phe Ala Gln Asp Gly Val Gln Ser Leu Leu Thr Gln Lys Trp 
        35                  40                  45              


Trp Gly Glu Met Asp Ser Thr Thr Pro 
    50                  55          


<210>  32
<211>  57
<212>  PRT
<213>  Equus caballus

<400>  32

Ser Ser Glu Glu Arg Ala Ser Arg Leu Leu Leu Arg Arg Cys Pro Leu 
1               5                   10                  15      


Trp Gly Gly Ala Thr Cys Phe Gln Leu Ala Met Gln Ala Asp Ala Arg 
            20                  25                  30          


Ala Phe Phe Ala Gln Asp Gly Ile Gln Ser Leu Leu Thr Gln Lys Trp 
        35                  40                  45              


Trp Gly Glu Met Asp Ser Thr Thr Pro 
    50                  55          


<210>  33
<211>  57
<212>  PRT
<213>  Camelus dromedarius

<400>  33

Ser Ser Glu Asp Arg Ala Ala Arg Leu Leu Leu Arg Arg Cys Pro Leu 
1               5                   10                  15      


Trp Gly Asp Ser Thr Cys Leu Gln Leu Ala Thr Gln Ala Asp Ala Arg 
            20                  25                  30          


Ala Phe Phe Ala Gln Asp Gly Val Gln Ser Leu Leu Thr Gln Lys Trp 
        35                  40                  45              


Trp Gly Glu Met Asp Ser Thr Thr Pro 
    50                  55          


<210>  34
<211>  57
<212>  PRT
<213>  Theropithecus gelada

<400>  34

Ser Ser Glu Val Arg Ala Ala Arg Leu Leu Leu Arg Arg Cys Pro Leu 
1               5                   10                  15      


Trp Gly Asp Ala Thr Cys Leu Gln Leu Ala Met Gln Ala Asp Ala Arg 
            20                  25                  30          


Ala Phe Phe Ala Gln Asp Gly Val Gln Ser Leu Leu Thr Gln Lys Trp 
        35                  40                  45              


Trp Gly Asp Met Ala Ser Thr Thr Pro 
    50                  55          


<210>  35
<211>  57
<212>  PRT
<213>  Orcinus orca

<400>  35

Ser Ser Glu Glu Arg Ala Ala His Leu Leu Leu Trp Arg Cys Pro Leu 
1               5                   10                  15      


Trp Gly Asp Ala Thr Cys Leu His Leu Ala Met Gln Ala Asp Ala Arg 
            20                  25                  30          


Ala Phe Phe Ala Gln Asp Gly Val Gln Ser Leu Leu Thr Gln Lys Trp 
        35                  40                  45              


Trp Gly Glu Met Asp Ser Thr Thr Pro 
    50                  55          


<210>  36
<211>  57
<212>  PRT
<213>  Chlorocebus sabaeus

<400>  36

Ser Ser Glu Val Arg Ala Ala Arg Leu Leu Leu Arg Arg Cys Pro Leu 
1               5                   10                  15      


Trp Gly Asp Ala Thr Cys Leu Gln Leu Ala Met Gln Ala Asp Ala Arg 
            20                  25                  30          


Ala Phe Phe Ala Gln Asp Gly Val Gln Ser Leu Leu Thr Gln Lys Trp 
        35                  40                  45              


Trp Gly Asp Met Ala Ser Thr Thr Pro 
    50                  55          


<210>  37
<211>  57
<212>  PRT
<213>  Chinchilla lanigera

<400>  37

Ser Ser Glu Thr Arg Ala Ser Arg Leu Leu Leu Arg Arg Cys Pro Leu 
1               5                   10                  15      


Trp Gly Asp Ala Thr Cys Leu Gln Leu Ala Met Gln Ala Asp Ala Arg 
            20                  25                  30          


Ala Phe Leu Ala Gln Asp Gly Val Gln Ser Val Leu Thr Gln Lys Trp 
        35                  40                  45              


Trp Gly Glu Met Asp Ser Thr Thr Pro 
    50                  55          


<210>  38
<211>  57
<212>  PRT
<213>  Elephantulus edwardii

<400>  38

Ser Asn Glu Lys Trp Ala Ala Arg Leu Leu Leu Arg Arg Cys Pro Leu 
1               5                   10                  15      


Trp Gly Asp Ala Thr Cys Leu Gln Leu Ala Met Gln Ala Asp Ser Arg 
            20                  25                  30          


Ala Phe Phe Ala Gln Asp Gly Val Gln Ser Leu Leu Thr Gln Lys Trp 
        35                  40                  45              


Trp Gly Glu Met Asp Ser Thr Thr Pro 
    50                  55          


<210>  39
<211>  57
<212>  PRT
<213>  Gorilla gorilla gorilla

<400>  39

Ser Asn Glu Val Arg Ala Ala Arg Leu Leu Leu Arg Arg Cys Pro Leu 
1               5                   10                  15      


Trp Gly Asp Ala Thr Cys Leu Gln Leu Ala Met Gln Ala Asp Ala Arg 
            20                  25                  30          


Ala Phe Phe Ala Gln Asp Gly Val Gln Ser Leu Leu Thr Gln Lys Trp 
        35                  40                  45              


Trp Gly Asp Met Ala Ser Thr Thr Pro 
    50                  55          


<210>  40
<211>  57
<212>  PRT
<213>  Sus scrofa

<400>  40

Asn Ser Glu Asn Arg Ala Ala Arg Leu Leu Leu Arg Arg Cys Pro Leu 
1               5                   10                  15      


Trp Gly Asp Ala Thr Cys Leu Gln Leu Ala Thr Gln Ala Asp Ala Arg 
            20                  25                  30          


Ala Phe Phe Ala Gln Asp Gly Val Gln Ser Leu Leu Thr Gln Lys Trp 
        35                  40                  45              


Trp Gly His Met Asp Ser Thr Thr Pro 
    50                  55          


<210>  41
<211>  57
<212>  PRT
<213>  Pan troglodytes

<400>  41

Ser Ser Glu Val Arg Ala Ala Arg Leu Leu Leu Arg Arg Cys Pro Leu 
1               5                   10                  15      


Trp Gly Asp Ala Thr Cys Leu Gln Leu Ala Met Gln Ala Asp Ala Arg 
            20                  25                  30          


Ala Phe Phe Ala Gln Asp Gly Val Gln Ser Leu Leu Thr Gln Lys Trp 
        35                  40                  45              


Trp Gly Asp Met Ala Ser Thr Thr Pro 
    50                  55          


<210>  42
<211>  9
<212>  PRT
<213>  Human immunodeficiency virus

<400>  42

Arg Lys Lys Arg Arg Gln Arg Arg Arg 
1               5                   


<210>  43
<211>  9
<212>  PRT
<213>  Unknown

<220>
<223>  HA tag

<400>  43

Tyr Pro Tyr Asp Val Pro Asp Tyr Ala 
1               5                   


<210>  44
<211>  21
<212>  RNA
<213>  Mus musculus

<400>  44
ggacaucgcc caaagugaac u                                                 21


<210>  45
<211>  21
<212>  RNA
<213>  Mus musculus

<400>  45
gcauccagag aggguucauu c                                                 21


<210>  46
<211>  347
<212>  PRT
<213>  Mus musculus

<400>  46

Met Val Gly Pro Glu Lys Glu Gln Ser Trp Ile Pro Lys Ile Phe Arg 
1               5                   10                  15      


Lys Lys Val Cys Thr Thr Phe Ile Val Asp Leu Ser Asp Asp Ala Gly 
            20                  25                  30          


Gly Thr Leu Cys Gln Cys Gly Gln Pro Arg Asp Ala His Pro Ser Val 
        35                  40                  45              


Ala Val Glu Asp Ala Phe Gly Ala Ala Val Val Thr Glu Trp Asn Ser 
    50                  55                  60                  


Asp Glu His Thr Thr Glu Lys Pro Thr Asp Ala Tyr Gly Asp Leu Asp 
65                  70                  75                  80  


Phe Thr Tyr Ser Gly Arg Lys His Ser Asn Phe Leu Arg Leu Ser Asp 
                85                  90                  95      


Arg Thr Asp Pro Ala Thr Val Tyr Ser Leu Val Thr Arg Ser Trp Gly 
            100                 105                 110         


Phe Arg Ala Pro Asn Leu Val Val Ser Val Leu Gly Gly Ser Gly Gly 
        115                 120                 125             


Pro Val Leu Gln Thr Trp Leu Gln Asp Leu Leu Arg Arg Gly Leu Val 
    130                 135                 140                 


Arg Ala Ala Gln Ser Thr Gly Ala Trp Ile Val Thr Gly Gly Leu His 
145                 150                 155                 160 


Thr Gly Ile Gly Arg His Val Gly Val Ala Val Arg Asp His Gln Thr 
                165                 170                 175     


Ala Ser Thr Gly Ser Ser Lys Val Val Ala Met Gly Val Ala Pro Trp 
            180                 185                 190         


Gly Val Val Arg Asn Arg Asp Met Leu Ile Asn Pro Lys Gly Ser Phe 
        195                 200                 205             


Pro Ala Arg Tyr Arg Trp Arg Gly Asp Pro Glu Asp Gly Val Glu Phe 
    210                 215                 220                 


Pro Leu Asp Tyr Asn Tyr Ser Ala Phe Phe Leu Val Asp Asp Gly Thr 
225                 230                 235                 240 


Tyr Gly Arg Leu Gly Gly Glu Asn Arg Phe Arg Leu Arg Phe Glu Ser 
                245                 250                 255     


Tyr Val Ala Gln Gln Lys Thr Gly Val Gly Gly Thr Gly Ile Asp Ile 
            260                 265                 270         


Pro Val Leu Leu Leu Leu Ile Asp Gly Asp Glu Lys Met Leu Lys Arg 
        275                 280                 285             


Ile Glu Asp Ala Thr Gln Ala Gln Leu Pro Cys Leu Leu Val Ala Gly 
    290                 295                 300                 


Ser Gly Gly Ala Ala Asp Cys Leu Val Glu Thr Leu Glu Asp Thr Leu 
305                 310                 315                 320 


Ala Pro Gly Ser Gly Gly Leu Arg Arg Gly Glu Ala Arg Asp Arg Ile 
                325                 330                 335     


Arg Arg Tyr Phe Pro Lys Gly Asp Pro Glu Val 
            340                 345         


<210>  47
<211>  342
<212>  PRT
<213>  Mus musculus

<400>  47

Leu Gln Ala Gln Val Glu Arg Ile Met Thr Arg Lys Glu Leu Leu Thr 
1               5                   10                  15      


Val Tyr Ser Ser Glu Asp Gly Ser Glu Glu Phe Glu Thr Ile Val Leu 
            20                  25                  30          


Arg Ala Leu Val Lys Ala Cys Gly Ser Ser Glu Ala Ser Ala Tyr Leu 
        35                  40                  45              


Asp Glu Leu Arg Leu Ala Val Ala Trp Asn Arg Val Asp Ile Ala Gln 
    50                  55                  60                  


Ser Glu Leu Phe Arg Gly Asp Ile Gln Trp Arg Ser Phe His Leu Glu 
65                  70                  75                  80  


Ala Ser Leu Met Asp Ala Leu Leu Asn Asp Arg Pro Glu Phe Val Arg 
                85                  90                  95      


Leu Leu Ile Ser His Gly Leu Ser Leu Gly His Phe Leu Thr Pro Val 
            100                 105                 110         


Arg Leu Ala Gln Leu Tyr Ser Ala Val Ser Pro Asn Ser Leu Ile Arg 
        115                 120                 125             


Asn Leu Leu Asp Gln Ala Ser His Ala Ser Ser Ser Lys Ser Pro Pro 
    130                 135                 140                 


Val Asn Gly Thr Val Glu Leu Arg Pro Pro Asn Val Gly Gln Val Leu 
145                 150                 155                 160 


Arg Thr Leu Leu Gly Glu Thr Cys Ala Pro Arg Tyr Pro Ala Arg Asn 
                165                 170                 175     


Thr Arg Asp Ser Tyr Leu Gly Gln Asp His Arg Glu Asn Asp Ser Leu 
            180                 185                 190         


Leu Met Asp Trp Ala Asn Lys Gln Pro Ser Thr Asp Ala Ser Phe Glu 
        195                 200                 205             


Gln Ala Pro Trp Ser Asp Leu Leu Ile Trp Ala Leu Leu Leu Asn Arg 
    210                 215                 220                 


Ala Gln Met Ala Ile Tyr Phe Trp Glu Lys Gly Ser Asn Ser Val Ala 
225                 230                 235                 240 


Ser Ala Leu Gly Ala Cys Leu Leu Leu Arg Val Met Ala Arg Leu Glu 
                245                 250                 255     


Ser Glu Ala Glu Glu Ala Ala Arg Arg Lys Asp Leu Ala Ala Thr Phe 
            260                 265                 270         


Glu Ser Met Ser Val Asp Leu Phe Gly Glu Cys Tyr His Asn Ser Glu 
        275                 280                 285             


Glu Arg Ala Ala Arg Leu Leu Leu Arg Arg Cys Pro Leu Trp Gly Glu 
    290                 295                 300                 


Ala Thr Cys Leu Gln Leu Ala Met Gln Ala Asp Ala Arg Ala Phe Phe 
305                 310                 315                 320 


Ala Gln Asp Gly Val Gln Ser Leu Leu Thr Gln Lys Trp Trp Gly Glu 
                325                 330                 335     


Met Asp Ser Thr Thr Pro 
            340         


<210>  48
<211>  347
<212>  PRT
<213>  Mus musculus

<400>  48

Ile Trp Ala Leu Leu Leu Ala Phe Phe Cys Pro Pro Leu Ile Tyr Thr 
1               5                   10                  15      


Asn Leu Ile Val Phe Arg Lys Ser Glu Glu Glu Pro Thr Gln Lys Asp 
            20                  25                  30          


Leu Asp Phe Asp Met Asp Ser Ser Ile Asn Gly Ala Gly Pro Pro Gly 
        35                  40                  45              


Thr Val Glu Pro Ser Ala Lys Val Ala Leu Glu Arg Arg Gln Arg Arg 
    50                  55                  60                  


Arg Pro Gly Arg Ala Leu Cys Cys Gly Lys Phe Ser Lys Arg Trp Ser 
65                  70                  75                  80  


Asp Phe Trp Gly Ala Pro Val Thr Ala Phe Leu Gly Asn Val Val Ser 
                85                  90                  95      


Tyr Leu Leu Phe Leu Leu Leu Phe Ala His Val Leu Leu Val Asp Phe 
            100                 105                 110         


Gln Pro Thr Lys Pro Ser Val Ser Glu Leu Leu Leu Tyr Phe Trp Ala 
        115                 120                 125             


Phe Thr Leu Leu Cys Glu Glu Leu Arg Gln Gly Leu Gly Gly Gly Trp 
    130                 135                 140                 


Gly Ser Leu Ala Ser Gly Gly Arg Gly Pro Asp Arg Ala Pro Leu Arg 
145                 150                 155                 160 


His Arg Leu His Leu Tyr Leu Ser Asp Thr Trp Asn Gln Cys Asp Leu 
                165                 170                 175     


Leu Ala Leu Thr Cys Phe Leu Leu Gly Val Gly Cys Arg Leu Thr Pro 
            180                 185                 190         


Gly Leu Phe Asp Leu Gly Arg Thr Val Leu Cys Leu Asp Phe Met Ile 
        195                 200                 205             


Phe Thr Leu Arg Leu Leu His Ile Phe Thr Val Asn Lys Gln Leu Gly 
    210                 215                 220                 


Pro Lys Ile Val Ile Val Ser Lys Met Met Lys Asp Val Phe Phe Phe 
225                 230                 235                 240 


Leu Phe Phe Leu Cys Val Trp Leu Val Ala Tyr Gly Val Ala Thr Glu 
                245                 250                 255     


Gly Ile Leu Arg Pro Gln Asp Arg Ser Leu Pro Ser Ile Leu Arg Arg 
            260                 265                 270         


Val Phe Tyr Arg Pro Tyr Leu Gln Ile Phe Gly Gln Ile Pro Gln Glu 
        275                 280                 285             


Glu Met Asp Val Ala Leu Met Ile Pro Gly Asn Cys Ser Met Glu Arg 
    290                 295                 300                 


Gly Ser Trp Ala His Pro Glu Gly Pro Val Ala Gly Ser Cys Val Ser 
305                 310                 315                 320 


Gln Tyr Ala Asn Trp Leu Val Val Leu Leu Leu Ile Val Phe Leu Leu 
                325                 330                 335     


Val Ala Asn Ile Leu Leu Leu Asn Leu Leu Ile 
            340                 345         


<210>  49
<211>  177
<212>  PRT
<213>  Mus musculus

<400>  49

Ala Met Phe Ser Tyr Thr Phe Ser Lys Val His Gly Asn Ser Asp Leu 
1               5                   10                  15      


Tyr Trp Lys Ala Gln Arg Tyr Ser Leu Ile Arg Glu Phe His Ser Arg 
            20                  25                  30          


Pro Ala Leu Ala Pro Pro Leu Ile Ile Ile Ser His Val Arg Leu Leu 
        35                  40                  45              


Ile Lys Trp Leu Arg Arg Cys Arg Arg Cys Arg Arg Ala Asn Leu Pro 
    50                  55                  60                  


Ala Ser Pro Val Phe Glu His Phe Arg Val Cys Leu Ser Lys Glu Ala 
65                  70                  75                  80  


Glu Arg Lys Leu Leu Thr Trp Glu Ser Val His Lys Glu Asn Phe Leu 
                85                  90                  95      


Leu Ala Gln Ala Arg Asp Lys Arg Asp Ser Asp Ser Glu Arg Leu Lys 
            100                 105                 110         


Arg Thr Ser Gln Lys Val Asp Thr Ala Leu Lys Gln Leu Gly Gln Ile 
        115                 120                 125             


Arg Glu Tyr Asp Arg Arg Leu Arg Gly Leu Glu Arg Glu Val Gln His 
    130                 135                 140                 


Cys Ser Arg Val Leu Thr Trp Met Ala Glu Ala Leu Ser His Ser Ala 
145                 150                 155                 160 


Leu Leu Pro Pro Gly Ala Pro Pro Pro Pro Ser Pro Thr Gly Ser Lys 
                165                 170                 175     


Asp 
    


<210>  50
<211>  122
<212>  PRT
<213>  Mus musculus

<400>  50

Leu Gln Ala Gln Val Glu Arg Ile Met Thr Arg Lys Glu Leu Leu Thr 
1               5                   10                  15      


Val Tyr Ser Ser Glu Asp Gly Ser Glu Glu Phe Glu Thr Ile Val Leu 
            20                  25                  30          


Arg Ala Leu Val Lys Ala Cys Gly Ser Ser Glu Ala Ser Ala Tyr Leu 
        35                  40                  45              


Asp Glu Leu Arg Leu Ala Val Ala Trp Asn Arg Val Asp Ile Ala Gln 
    50                  55                  60                  


Ser Glu Leu Phe Arg Gly Asp Ile Gln Trp Arg Ser Phe His Leu Glu 
65                  70                  75                  80  


Ala Ser Leu Met Asp Ala Leu Leu Asn Asp Arg Pro Glu Phe Val Arg 
                85                  90                  95      


Leu Leu Ile Ser His Gly Leu Ser Leu Gly His Phe Leu Thr Pro Val 
            100                 105                 110         


Arg Leu Ala Gln Leu Tyr Ser Ala Val Ser 
        115                 120         


<210>  51
<211>  100
<212>  PRT
<213>  Mus musculus

<400>  51

Ser Leu Gly His Phe Leu Thr Pro Val Arg Leu Ala Gln Leu Tyr Ser 
1               5                   10                  15      


Ala Val Ser Pro Asn Ser Leu Ile Arg Asn Leu Leu Asp Gln Ala Ser 
            20                  25                  30          


His Ala Ser Ser Ser Lys Ser Pro Pro Val Asn Gly Thr Val Glu Leu 
        35                  40                  45              


Arg Pro Pro Asn Val Gly Gln Val Leu Arg Thr Leu Leu Gly Glu Thr 
    50                  55                  60                  


Cys Ala Pro Arg Tyr Pro Ala Arg Asn Thr Arg Asp Ser Tyr Leu Gly 
65                  70                  75                  80  


Gln Asp His Arg Glu Asn Asp Ser Leu Leu Met Asp Trp Ala Asn Lys 
                85                  90                  95      


Gln Pro Ser Thr 
            100 


<210>  52
<211>  124
<212>  PRT
<213>  Mus musculus

<400>  52

Ser Tyr Leu Gly Gln Asp His Arg Glu Asn Asp Ser Leu Leu Met Asp 
1               5                   10                  15      


Trp Ala Asn Lys Gln Pro Ser Thr Asp Ala Ser Phe Glu Gln Ala Pro 
            20                  25                  30          


Trp Ser Asp Leu Leu Ile Trp Ala Leu Leu Leu Asn Arg Ala Gln Met 
        35                  40                  45              


Ala Ile Tyr Phe Trp Glu Lys Gly Ser Asn Ser Val Ala Ser Ala Leu 
    50                  55                  60                  


Gly Ala Cys Leu Leu Leu Arg Val Met Ala Arg Leu Glu Ser Glu Ala 
65                  70                  75                  80  


Glu Glu Ala Ala Arg Arg Lys Asp Leu Ala Ala Thr Phe Glu Ser Met 
                85                  90                  95      


Ser Val Asp Leu Phe Gly Glu Cys Tyr His Asn Ser Glu Glu Arg Ala 
            100                 105                 110         


Ala Arg Leu Leu Leu Arg Arg Cys Pro Leu Trp Gly 
        115                 120                 


<210>  53
<211>  371
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Fusion protein of SEQ ID NO: and SEQ ID NO:57

<400>  53

Leu Gln Ala Gln Val Glu Arg Ile Met Thr Arg Lys Glu Leu Leu Thr 
1               5                   10                  15      


Val Tyr Ser Ser Glu Asp Gly Ser Glu Glu Phe Glu Thr Ile Val Leu 
            20                  25                  30          


Arg Ala Leu Val Lys Ala Cys Gly Ser Ser Glu Ala Ser Ala Tyr Leu 
        35                  40                  45              


Asp Glu Leu Arg Leu Ala Val Ala Trp Asn Arg Val Asp Ile Ala Gln 
    50                  55                  60                  


Ser Glu Leu Phe Arg Gly Asp Ile Gln Trp Arg Ser Phe His Leu Glu 
65                  70                  75                  80  


Ala Ser Leu Met Asp Ala Leu Leu Asn Asp Arg Pro Glu Phe Val Arg 
                85                  90                  95      


Leu Leu Ile Ser His Gly Leu Ser Leu Gly His Phe Leu Thr Pro Val 
            100                 105                 110         


Arg Leu Ala Gln Leu Tyr Ser Ala Val Ser Pro Asn Ser Leu Ile Arg 
        115                 120                 125             


Asn Leu Leu Asp Gln Ala Ser His Ala Ser Ser Ser Lys Ser Pro Pro 
    130                 135                 140                 


Val Asn Gly Thr Val Glu Leu Arg Pro Pro Asn Val Gly Gln Val Leu 
145                 150                 155                 160 


Arg Thr Leu Leu Gly Glu Thr Cys Ala Pro Arg Tyr Pro Ala Arg Asn 
                165                 170                 175     


Thr Arg Asp Ser Tyr Leu Gly Gln Asp His Arg Glu Asn Asp Ser Leu 
            180                 185                 190         


Leu Met Asp Trp Ala Asn Lys Gln Pro Ser Thr Asp Ala Ser Phe Glu 
        195                 200                 205             


Gln Ala Pro Trp Ser Asp Leu Leu Ile Trp Ala Leu Leu Leu Asn Arg 
    210                 215                 220                 


Ala Gln Met Ala Ile Tyr Phe Trp Glu Lys Gly Ser Asn Ser Val Ala 
225                 230                 235                 240 


Ser Ala Leu Gly Ala Cys Leu Leu Leu Arg Val Met Ala Arg Leu Glu 
                245                 250                 255     


Ser Glu Ala Glu Glu Ala Ala Arg Arg Lys Asp Leu Ala Ala Thr Phe 
            260                 265                 270         


Glu Ser Met Ser Val Asp Leu Phe Gly Glu Cys Tyr His Asn Ser Glu 
        275                 280                 285             


Glu Arg Ala Ala Arg Leu Leu Leu Arg Arg Cys Pro Leu Trp Gly Glu 
    290                 295                 300                 


Ala Thr Cys Leu Gln Leu Ala Met Gln Ala Asp Ala Arg Ala Phe Phe 
305                 310                 315                 320 


Ala Gln Asp Gly Val Gln Ser Leu Leu Thr Gln Lys Trp Trp Gly Glu 
                325                 330                 335     


Met Asp Ser Thr Thr Pro Leu Glu Asn Gly Gly Thr Ser Leu Ser Glu 
            340                 345                 350         


Lys Thr Val Leu Leu Leu Val Thr Pro Phe Leu Ala Ala Ala Trp Ser 
        355                 360                 365             


Leu His Pro 
    370     


<210>  54
<211>  57
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Mutant of SEQ ID NO:5 with F34Y and F35Y

<400>  54

Asn Ser Glu Glu Arg Ala Ala Arg Leu Leu Leu Arg Arg Cys Pro Leu 
1               5                   10                  15      


Trp Gly Glu Ala Thr Cys Leu Gln Leu Ala Met Gln Ala Asp Ala Arg 
            20                  25                  30          


Ala Tyr Tyr Ala Gln Asp Gly Val Gln Ser Leu Leu Thr Gln Lys Trp 
        35                  40                  45              


Trp Gly Glu Met Asp Ser Thr Thr Pro 
    50                  55          


<210>  55
<211>  57
<212>  PRT
<213>  Mus musculus

<400>  55

Asn Ser Glu Asp Arg Ala Phe Ala Leu Leu Val Arg Arg Asn His Ser 
1               5                   10                  15      


Trp Ser Arg Thr Thr Cys Leu His Leu Ala Thr Glu Ala Asp Ala Lys 
            20                  25                  30          


Ala Phe Phe Ala His Asp Gly Val Gln Ala Phe Leu Thr Lys Ile Trp 
        35                  40                  45              


Trp Gly Asp Met Ala Thr Gly Thr Pro 
    50                  55          


<210>  56
<211>  69
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Fusion protein composed of TAT peptide and SEQ ID NO: 5

<400>  56

Arg Lys Lys Arg Arg Gln Arg Arg Arg Ser Gln Pro Asn Ser Glu Glu 
1               5                   10                  15      


Arg Ala Ala Arg Leu Leu Leu Arg Arg Cys Pro Leu Trp Gly Glu Ala 
            20                  25                  30          


Thr Cys Leu Gln Leu Ala Met Gln Ala Asp Ala Arg Ala Phe Phe Ala 
        35                  40                  45              


Gln Asp Gly Val Gln Ser Leu Leu Thr Gln Lys Trp Trp Gly Glu Met 
    50                  55                  60                  


Asp Ser Thr Thr Pro 
65                  


<210>  57
<211>  29
<212>  PRT
<213>  Unknown

<220>
<223>  Glycosylphosphatidylinositol (GPI) signal anchor sequence

<400>  57

Leu Glu Asn Gly Gly Thr Ser Leu Ser Glu Lys Thr Val Leu Leu Leu 
1               5                   10                  15      


Val Thr Pro Phe Leu Ala Ala Ala Trp Ser Leu His Pro 
            20                  25                  


<210>  58
<211>  18
<212>  PRT
<213>  Unknown

<220>
<223>  C-terminal targeting signal of K-Ras4B

<400>  58

Ser Lys Asp Gly Lys Lys Lys Lys Lys Lys Ser Arg Thr Arg Cys Thr 
1               5                   10                  15      


Val Met 
        


