                         SEQUENCE LISTING

<110>  Humabs BioMed SA
       Institut Pasteur
 
<120>  ANTIBODIES AND METHODS FOR TREATMENT OF LYSSAVIRUS INFECTION

<130>  HB01P036WO

<160>  226   

<170>  PatentIn version 3.5

<210>  1
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  RVA122 CDRH1 aa

<400>  1

Gly Asp Ser Met Asn Asn Phe Tyr 
1               5               


<210>  2
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  RVA122 CDRH2 aa

<400>  2

Ile Tyr Tyr Ser Gly Thr Thr 
1               5           


<210>  3
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  RVA122 CDRH3 aa

<400>  3

Ala Arg Asp Ser Gly Asp Tyr Val Ser Tyr Tyr Tyr Tyr Gly Met Asp 
1               5                   10                  15      


Val 
    


<210>  4
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  RVA122 CDRL1 aa

<400>  4

Ser Ser Asn Ile Gly Ser Asn Tyr 
1               5               


<210>  5

<400>  5
000

<210>  6
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  RVA122 CDRL2 long aa

<400>  6

Leu Ile Tyr Lys Ser Asp Lys Arg Pro 
1               5                   


<210>  7
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  RVA122 CDRL3 aa

<400>  7

Ala Ala Trp Asp Asn Arg Leu Ser Gly Trp Leu 
1               5                   10      


<210>  8
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  RVA122 CDRH1 nuc

<400>  8
ggtgactcca tgaataattt ctac                                              24


<210>  9
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  RVA122 CDRH2 nuc

<400>  9
atctattaca gtgggaccac c                                                 21


<210>  10
<211>  51
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  RVA122 CDRH3 nuc

<400>  10
gcgagagact ccggtgacta cgtcagctac tactattatg gtatggacgt c                51


<210>  11
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  RVA122 CDRL1 nuc

<400>  11
agctccaaca tcggaagtaa ttat                                              24


<210>  12

<400>  12
000

<210>  13
<211>  27
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  RVA122 CDRL2 long nuc

<400>  13
cttatttaca agagtgataa gcggccc                                           27


<210>  14
<211>  33
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  RVA122 CDRL3 nuc

<400>  14
gcagcatggg ataacaggct gagtggttgg ctc                                    33


<210>  15
<211>  123
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  RVA122 heavy chain aa

<400>  15

Gln Val His Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Asp Ser Met Asn Asn Phe 
            20                  25                  30          


Tyr Trp Gly Trp Ile Arg Gln Pro Ala Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Tyr Ile Tyr Tyr Ser Gly Thr Thr Asn Tyr Asn Pro Ser Leu Lys 
    50                  55                  60                  


Ser Arg Val Thr Ile Ser Ile Asp Thr Ser Lys Asn Gln Phe Ser Leu 
65                  70                  75                  80  


Lys Val Asn Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Asp Ser Gly Asp Tyr Val Ser Tyr Tyr Tyr Tyr Gly Met Asp Val 
            100                 105                 110         


Trp Gly Pro Gly Thr Thr Val Thr Val Ser Ser 
        115                 120             


<210>  16
<211>  110
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  RVA122 light chain aa

<400>  16

Gln Ser Val Leu Thr Gln Ser Pro Ser Ala Ser Asp Thr Pro Gly Gln 
1               5                   10                  15      


Arg Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn 
            20                  25                  30          


Tyr Val Tyr Trp Tyr Gln Gln Phe Pro Gly Thr Ala Pro Lys Leu Leu 
        35                  40                  45              


Ile Tyr Lys Ser Asp Lys Arg Pro Ser Gly Val Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Thr Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Arg 
65                  70                  75                  80  


Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ala Trp Asp Asn Arg Leu 
                85                  90                  95      


Ser Gly Trp Leu Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105                 110 


<210>  17
<211>  370
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  RVA122 heavy chain nuc

<400>  17
caggtgcacc tgcaggagtc gggcccagga ctggtgaagc cttcggagac cctgtccctc       60

acctgcactg tctctggtga ctccatgaat aatttctact ggggctggat ccggcagccc      120

gcagggaagg gactggagtg gattggatat atctattaca gtgggaccac caactacaac      180

ccctccctca agagtcgagt caccatatca atagacacgt ccaagaacca attctccctg      240

aaggtgaact ctgtgaccgc tgcggacacg gccgtgtatt attgtgcgag agactccggt      300

gactacgtca gctactacta ttatggtatg gacgtctggg gcccagggac cacggtcacc      360

gtctcctcag                                                             370


<210>  18
<211>  331
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  RVA122 light chain nuc

<400>  18
cagtctgtgc tgactcagtc accctcagcg tctgataccc ccgggcagag ggtcaccatc       60

tcttgttctg gaagcagctc caacatcgga agtaattatg tgtattggta ccagcagttc      120

ccaggaacgg cccccaaact ccttatttac aagagtgata agcggccctc aggggtccct      180

gaccgattct ctggctccac gtctggcacc tcagcctccc tggccatcag tgggctccgg      240

tccgaagatg aggctgatta ttactgtgca gcatgggata acaggctgag tggttggctc      300

ttcggcggag ggacgaagct gaccgtccta g                                     331


<210>  19
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  RVA144 CDRH1 aa

<400>  19

Gly Gly Ser Ile Ser Ser Thr Ile Phe Tyr 
1               5                   10  


<210>  20
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  RVA144 CDRH2 aa

<400>  20

Val Tyr Tyr Asn Gly His Thr 
1               5           


<210>  21
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  RVA144 CDRH3 aa

<400>  21

Ala Arg Pro Ser Thr Tyr Asp Tyr Ser Ile Gly Arg 
1               5                   10          


<210>  22
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  RVA144 CDRL1 aa

<400>  22

Ser Ser Asn Ile Gly Ala Gly Tyr Asp 
1               5                   


<210>  23

<400>  23
000

<210>  24
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  RVA144 CDRL2 long aa

<400>  24

Leu Ile Tyr Gly Asn Thr Lys Arg Pro 
1               5                   


<210>  25
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  RVA144 CDRL3 aa

<400>  25

Gln Ser Phe Asp Ser Ser Leu Ser Ala Trp Val 
1               5                   10      


<210>  26
<211>  30
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  RVA144 CDRH1 nuc

<400>  26
ggtggttcca tcagcagtac tattttctac                                        30


<210>  27
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  RVA144 CDRH2 nuc

<400>  27
gtctattata atggacacac c                                                 21


<210>  28
<211>  36
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  RVA144 CDRH3 nuc

<400>  28
gcgagaccct caacatatga ctacagtatt gggcgc                                 36


<210>  29
<211>  27
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  RVA144 CDRL1 nuc

<400>  29
agctccaaca tcggggcagg ttatgat                                           27


<210>  30

<400>  30
000

<210>  31
<211>  27
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  RVA144 CDRL2 long nuc

<400>  31
ctcatctatg gtaacaccaa gcggccc                                           27


<210>  32
<211>  33
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  RVA144 CDRL3 nuc

<400>  32
cagtcctttg acagcagcct gagtgcttgg gta                                    33


<210>  33
<211>  120
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  RVA144 heavy chain aa

<400>  33

Gln Leu Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Gly Ser Ile Ser Ser Thr 
            20                  25                  30          


Ile Phe Tyr Trp Gly Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu 
        35                  40                  45              


Trp Ile Gly Ser Val Tyr Tyr Asn Gly His Thr Tyr Tyr Asn Pro Ser 
    50                  55                  60                  


Leu Lys Ser Arg Val Ala Ile Ser Ile Asp Lys Ser Lys Asn Gln Phe 
65                  70                  75                  80  


Ser Leu Arg Leu Asn Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr 
                85                  90                  95      


Cys Ala Arg Pro Ser Thr Tyr Asp Tyr Ser Ile Gly Arg Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser 
        115                 120 


<210>  34
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  RVA144 light chain aa

<400>  34

Gln Ser Val Leu Thr Gln Pro Pro Ser Val Ser Arg Ala Pro Gly Gln 
1               5                   10                  15      


Arg Val Thr Ile Ser Cys Thr Gly Ser Ser Ser Asn Ile Gly Ala Gly 
            20                  25                  30          


Tyr Asp Val His Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu 
        35                  40                  45              


Leu Ile Tyr Gly Asn Thr Lys Arg Pro Ser Gly Val Pro Asp Arg Phe 
    50                  55                  60                  


Ser Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Thr Gly Leu 
65                  70                  75                  80  


Leu Thr Glu Asp Glu Ala Asp Tyr Tyr Cys Gln Ser Phe Asp Ser Ser 
                85                  90                  95      


Leu Ser Ala Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105                 110     


<210>  35
<211>  361
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  RVA144 heavy chain nuc

<400>  35
cagctgcagc tgcaggagtc gggcccagga ctggtgaagc cctcggagac cctgtccctc       60

acttgcactg tctctggtgg ttccatcagc agtactattt tctactgggg ctggatccgc      120

cagcccccag ggaagggact ggagtggatt gggagtgtct attataatgg acacacctac      180

tacaatccgt ccctcaagag tcgagtcgcc atatccattg acaagtccaa gaaccagttc      240

tccctgaggc ttaactctgt gaccgccgcg gacacggctg tatattactg tgcgagaccc      300

tcaacatatg actacagtat tgggcgctgg ggccagggaa ccctggtcac cgtctcctca      360

g                                                                      361


<210>  36
<211>  334
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  RVA144 light chain nuc

<400>  36
cagtccgtgc tgacgcagcc gccctcagtg tctcgggccc cagggcagag ggtcaccatc       60

tcctgcactg ggagcagctc caacatcggg gcaggttatg atgtccactg gtaccagcaa      120

cttccaggaa cagcccccaa actcctcatc tatggtaaca ccaagcggcc ctcaggggtc      180

cctgaccgat tctctggctc caagtctggc acctcagcct ccctggccat cactgggctc      240

ctgactgagg atgaggctga ttattactgc cagtcctttg acagcagcct gagtgcttgg      300

gtattcggcg gagggaccaa actgaccgtc ctgg                                  334


<210>  37
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  RVB185 CDRH1 aa

<400>  37

Gly Ala Pro Val Ser Gly Val Asn Ser Tyr 
1               5                   10  


<210>  38
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  RVB185 CDRH2 aa

<400>  38

Ile Lys Tyr Ser Gly Ser Thr 
1               5           


<210>  39
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  RVB185 CDRH3 aa

<400>  39

Ala Arg Gln Ser Thr Met Thr Gly Arg Asp Tyr 
1               5                   10      


<210>  40
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  RVB185 CDRL1 aa

<400>  40

Arg Ser Asn Ile Gly Ser His Pro 
1               5               


<210>  41

<400>  41
000

<210>  42
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  RVB185 CDRL2 long aa

<400>  42

Leu Ile Tyr Gly Asp Ser Gln Arg Pro 
1               5                   


<210>  43
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  RVB185 CDRL3 aa

<400>  43

Ala Ala Trp Asp Asp Ser Leu Ser Gly Leu Trp Val 
1               5                   10          


<210>  44
<211>  30
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  RVB185 CDRH1 nuc

<400>  44
ggtgcccccg tcagtggtgt taactcctac                                        30


<210>  45
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  RVB185 CDRH2 nuc

<400>  45
atcaagtaca gtgggagcac c                                                 21


<210>  46
<211>  33
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  RVB185 CDRH3 nuc

<400>  46
gccagacaaa gtactatgac gggccgggac tac                                    33


<210>  47
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  RVB185 CDRL1 nuc

<400>  47
agatccaaca tcggaagcca tcct                                              24


<210>  48

<400>  48
000

<210>  49
<211>  27
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  RVB185 CDRL2 long nuc

<400>  49
ctcatctatg gtgatagtca gcgaccc                                           27


<210>  50
<211>  36
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  RVB185 CDRL3 nuc

<400>  50
gcagcatggg atgacagcct gagtggcctt tgggtg                                 36


<210>  51
<211>  119
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  RVB185 heavy chain aa

<400>  51

Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Ser Val Ser Gly Ala Pro Val Ser Gly Val 
            20                  25                  30          


Asn Ser Tyr Trp Val Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu 
        35                  40                  45              


Trp Ile Ala Thr Ile Lys Tyr Ser Gly Ser Thr His Arg Ser Pro Ser 
    50                  55                  60                  


Leu Arg Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe 
65                  70                  75                  80  


Ser Leu Glu Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr 
                85                  90                  95      


Cys Ala Arg Gln Ser Thr Met Thr Gly Arg Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser 
        115                 


<210>  52
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  RVB185 light chain aa

<400>  52

Gln Ser Val Leu Thr Gln Pro Pro Ser Ala Ser Gly Thr Pro Gly Gln 
1               5                   10                  15      


Arg Val Thr Ile Ser Cys Ser Gly Ser Arg Ser Asn Ile Gly Ser His 
            20                  25                  30          


Pro Val Asn Trp Tyr Gln Gln Leu Pro Gly Ala Ala Pro Lys Leu Leu 
        35                  40                  45              


Ile Tyr Gly Asp Ser Gln Arg Pro Ser Gly Val Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Lys Ser Gly Pro Ser Ala Ser Leu Ala Ile Ser Gly Leu Gln 
65                  70                  75                  80  


Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ala Trp Asp Asp Ser Leu 
                85                  90                  95      


Ser Gly Leu Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105                 110     


<210>  53
<211>  358
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  RVB185 heavy chain nuc

<400>  53
caggtgcagc tgcaggagtc gggcccagga ctggtgaagc cttcggagac cctgtccctc       60

acctgcagtg tctccggtgc ccccgtcagt ggtgttaact cctactgggt gtggatccgc      120

cagccccccg ggaaggggct ggagtggatt gcgactatca agtacagtgg gagcacccac      180

cgtagcccgt cgctcaggag tcgagtcacc atatccgtag acacgtccaa gaatcagttc      240

tccctggagc tgagctctgt gaccgccgct gacacggctg tatattactg tgccagacaa      300

agtactatga cgggccggga ctactggggc cagggaaccc tggtcaccgt ctcctcag        358


<210>  54
<211>  334
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  RVB185 light chain nuc

<400>  54
cagtctgtgc tgactcagcc accctcagcg tctgggaccc ccgggcagag ggtcaccatc       60

tcttgttctg gaagcagatc caacatcgga agccatcctg taaactggta ccagcagctc      120

ccgggagcgg cccccaagct cctcatctat ggtgatagtc agcgaccctc aggggtccct      180

gaccgattct ctggctccaa gtctggcccc tcagcctccc tggccatcag tggactccag      240

tctgaagatg aggctgatta ttactgtgca gcatgggatg acagcctgag tggcctttgg      300

gtgttcggcg gagggaccaa gctgaccgtc ctaa                                  334


<210>  55
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  RVB492 CDRH1 aa

<400>  55

Gly Phe Ser Phe Ser Ser Tyr Ala 
1               5               


<210>  56
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  RVB492 CDRH2 aa

<400>  56

Leu Asn Ser Ile Asp His Arg Thr 
1               5               


<210>  57
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  RVB492 CDRH3 aa

<400>  57

Ala Arg Gly Val Gly Leu Trp Phe Gly Glu Leu Ser Trp Asn Tyr Phe 
1               5                   10                  15      


Asp Tyr 
        


<210>  58
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  RVB492 CDRL1 aa

<400>  58

Ser Asn Asp Ile Gly Gly Tyr Asn Tyr 
1               5                   


<210>  59

<400>  59
000

<210>  60
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  RVB492 CDRL2 long aa

<400>  60

Met Ile Phe Tyr Val Asn Lys Arg Pro 
1               5                   


<210>  61
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  RVB492 CDRL3 aa

<400>  61

Cys Ser Phe Ala Gly Ser Tyr Ser Leu 
1               5                   


<210>  62
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  RVB492 CDRH1 nuc

<400>  62
ggattcagct ttagcagcta tgcc                                              24


<210>  63
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  RVB492 CDRH2 nuc

<400>  63
cttaattcta ttgatcatag aaca                                              24


<210>  64
<211>  54
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  RVB492 CDRH3 nuc

<400>  64
gctcgggggg tgggactatg gttcggtgaa ttatcctgga attactttga ctac             54


<210>  65
<211>  27
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  RVB492 CDRL1 nuc

<400>  65
agcaatgata ttggtggtta taactat                                           27


<210>  66

<400>  66
000

<210>  67
<211>  27
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  RVB492 CDRL2 long nuc

<400>  67
atgatttttt atgtcaataa gcggccc                                           27


<210>  68
<211>  27
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  RVB492 CDRL3 nuc

<400>  68
tgctcatttg caggcagtta ctcctta                                           27


<210>  69
<211>  125
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  RVB492 heavy chain variant 1 aa

<400>  69

Glu Val Gln Leu Met Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Met Arg Leu Tyr Cys Ala Ala Ser Gly Phe Ser Phe Ser Ser Tyr 
            20                  25                  30          


Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ser Leu Asn Ser Ile Asp His Arg Thr Asp Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asp Ser Leu Arg Val Glu Asp Ser Ala Met Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Val Gly Leu Trp Phe Gly Glu Leu Ser Trp Asn Tyr Phe 
            100                 105                 110         


Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125 


<210>  70
<211>  125
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  RVB492 heavy chain variant 2 aa

<400>  70

Glu Val Gln Leu Val Gln Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Met Arg Leu Tyr Cys Ala Ala Ser Gly Phe Ser Phe Ser Ser Tyr 
            20                  25                  30          


Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ser Leu Asn Ser Ile Asp His Arg Thr Asp Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asp Ser Leu Arg Val Glu Asp Ser Ala Met Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Val Gly Leu Trp Phe Gly Glu Leu Ser Trp Asn Tyr Phe 
            100                 105                 110         


Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125 


<210>  71
<211>  109
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  RVB492 light chain aa

<400>  71

Gln Ser Ala Leu Thr Gln Pro Arg Ser Val Ser Gly Ser Pro Gly Gln 
1               5                   10                  15      


Ser Val Thr Ile Ser Cys Thr Gly Thr Ser Asn Asp Ile Gly Gly Tyr 
            20                  25                  30          


Asn Tyr Val Ser Trp Tyr Gln Gln His Pro Gly Lys Ala Pro Lys Leu 
        35                  40                  45              


Met Ile Phe Tyr Val Asn Lys Arg Pro Ser Gly Val Pro Asp Arg Phe 
    50                  55                  60                  


Ser Gly Ser Lys Ser Gly Asn Thr Ala Ser Leu Thr Ile Ser Gly Leu 
65                  70                  75                  80  


Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Cys Ser Phe Ala Gly Ser 
                85                  90                  95      


Tyr Ser Leu Phe Gly Arg Gly Thr Lys Leu Thr Val Leu 
            100                 105                 


<210>  72
<211>  376
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  RVB492 heavy chain variant 1 nuc

<400>  72
gaggtgcagc tgatggagtc tgggggaggc ctggtacagc cgggggggtc catgagactc       60

tactgtgcag cctctggatt cagctttagc agctatgcca tgagctgggt ccgccaggct      120

ccagggaagg ggctcgagtg ggtctcaagt cttaattcta ttgatcatag aacagactat      180

gcagactccg tgaagggccg gttcaccatc tccagagaca attccaagaa caccctgtat      240

ttacaaatgg acagcctgag agtcgaggac tcggccatgt attactgtgc tcggggggtg      300

ggactatggt tcggtgaatt atcctggaat tactttgact actggggcca gggaaccctg      360

gtcaccgtct cctcag                                                      376


<210>  73
<211>  376
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  RVB492 heavy chain variant 2 nuc

<400>  73
gaggtgcagc tggtgcagtc tgggggaggc ctggtacagc cgggggggtc catgagactc       60

tactgtgcag cctctggatt cagctttagc agctatgcca tgagctgggt ccgccaggct      120

ccagggaagg ggctcgagtg ggtctcaagt cttaattcta ttgatcatag aacagactat      180

gcagactccg tgaagggccg gttcaccatc tccagagaca attccaagaa caccctgtat      240

ttacaaatgg acagcctgag agtcgaggac tcggccatgt attactgtgc tcggggggtg      300

ggactatggt tcggtgaatt atcctggaat tactttgact actggggcca gggaaccctg      360

gtcaccgtct cctcag                                                      376


<210>  74
<211>  328
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  RVB492 light chain nuc

<400>  74
cagtctgccc tgactcagcc tcgctcagtg tccgggtctc ctggacagtc agtcaccatc       60

tcctgcactg gaaccagcaa tgatattggt ggttataact atgtctcctg gtaccaacaa      120

cacccaggca aagcccccaa actcatgatt ttttatgtca ataagcggcc ctcaggggtc      180

cctgatcgct tctctggctc caagtctggc aacacggcct ccctgaccat ctctgggctc      240

caggctgagg atgaagctga ttattactgc tgctcatttg caggcagtta ctccttattc      300

ggcagaggga ccaagctgac cgtcctag                                         328


<210>  75
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  RVC3 CDRH1 aa

<400>  75

Thr Phe Thr Phe Arg Asn Tyr Ala 
1               5               


<210>  76
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  RVC3 CDRH2 aa

<400>  76

Ile Ser Ala Ser Gly Ser Ser Thr 
1               5               


<210>  77
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  RVC3 CDRH3 aa

<400>  77

Ala Lys Phe Ala His Asp Phe Trp Ser Gly Tyr Ser Tyr Phe Asp Ser 
1               5                   10                  15      


<210>  78
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  RVC3 CDRL1 aa

<400>  78

Gln Ser Val Asn Ser Asn 
1               5       


<210>  79

<400>  79
000

<210>  80
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  RVC3 CDRL2 long aa

<400>  80

Leu Ile Tyr Gly Ala Ser Thr Arg Ala 
1               5                   


<210>  81
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  RVC3 CDRL3 aa

<400>  81

Gln Gln Tyr Asn Asn Trp Val Ser Ile Thr 
1               5                   10  


<210>  82
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  RVC3 CDRH1 nuc

<400>  82
acattcacgt ttagaaacta tgcc                                              24


<210>  83
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  RVC3 CDRH2 nuc

<400>  83
attagtgcta gtggtagtag cacg                                              24


<210>  84
<211>  48
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  RVC3 CDRH3 nuc

<400>  84
gcgaaatttg ctcacgattt ttggagtggt tattcttact ttgactcc                    48


<210>  85
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  RVC3 CDRL1 nuc

<400>  85
cagagtgtta acagcaac                                                     18


<210>  86

<400>  86
000

<210>  87
<211>  27
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  RVC3 CDRL2 long nuc

<400>  87
ctcatctatg gtgcatccac cagggcc                                           27


<210>  88
<211>  30
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  RVC3 CDRL3 nuc

<400>  88
cagcagtata ataattgggt ttcgatcacc                                        30


<210>  89
<211>  123
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  RVC3 heavy chain aa

<400>  89

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Thr Phe Thr Phe Arg Asn Tyr 
            20                  25                  30          


Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Asp Trp Val 
        35                  40                  45              


Ser Gly Ile Ser Ala Ser Gly Ser Ser Thr Asn Tyr Ala Ala Ser Leu 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Phe Ala His Asp Phe Trp Ser Gly Tyr Ser Tyr Phe Asp Ser 
            100                 105                 110         


Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120             


<210>  90
<211>  108
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  RVC3 light chain aa

<400>  90

Glu Ile Val Met Thr Gln Ser Pro Ala Thr Leu Ser Val Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Gly Gln Ser Val Asn Ser Asn 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile 
        35                  40                  45              


Tyr Gly Ala Ser Thr Arg Ala Thr Gly Ile Pro Ala Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Ser 
65                  70                  75                  80  


Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr Asn Asn Trp Val Ser 
                85                  90                  95      


Ile Thr Phe Gly Gln Gly Thr Arg Leu Glu Ile Lys 
            100                 105             


<210>  91
<211>  370
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  RVC3 heavy chain nuc

<400>  91
gaggtgcagc tgttggagtc tgggggaggc ctggtgcagc cgggggggtc cctgagactc       60

tcctgtgcag cctctacatt cacgtttaga aactatgcca tgtcctgggt ccgccaggct      120

ccagggaagg ggctggactg ggtctcaggg attagtgcta gtggtagtag cacgaattat      180

gcagcctccc tgaagggccg atttaccatc tccagagaca attccaagaa cacattgtat      240

ctgcaaatga acagcctgag agccgaggac acggccgtct attactgtgc gaaatttgct      300

cacgattttt ggagtggtta ttcttacttt gactcctggg gccagggaac cctggtcacc      360

gtctcctcag                                                             370


<210>  92
<211>  325
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  RVC3 light chain nuc

<400>  92
gaaatagtga tgacgcagtc tccagccacc ctgtctgtgt ctccagggga aagagccacc       60

ctctcctgca gggccggtca gagtgttaac agcaacttag cctggtacca gcagaaacct      120

gggcaggctc ccagactcct catctatggt gcatccacca gggccactgg tatcccagcc      180

aggttcagtg gcagtgggtc tgggacagag ttcactctca ccatcagcag cctgcagtct      240

gaagattttg cagtttatta ctgtcagcag tataataatt gggtttcgat caccttcggc      300

caagggacac gactggagat taaac                                            325


<210>  93
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  RVC20 CDRH1 aa

<400>  93

Gly Gly Ser Phe Ser Ser Gly Ser Tyr Ser 
1               5                   10  


<210>  94
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  RVC20 CDRH2 aa

<400>  94

Ile Tyr Tyr Ser Gly Ser Thr 
1               5           


<210>  95
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  RVC20 CDRH3 aa

<400>  95

Ala Arg Gly Thr Tyr Ser Asp Phe Trp Ser Gly Ser Pro Leu Asp Tyr 
1               5                   10                  15      


<210>  96
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  RVC20 CDRL1 aa

<400>  96

Gln Gly Ile Ser Asn Tyr 
1               5       


<210>  97

<400>  97
000

<210>  98
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  RVC20 CDRL2 long aa

<400>  98

Leu Ile Tyr Ala Ala Ser Ser Leu Gln 
1               5                   


<210>  99
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  RVC20 CDRL3 aa

<400>  99

Gln Gln Tyr Asp Thr Tyr Pro Leu Thr 
1               5                   


<210>  100
<211>  30
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  RVC20 CDRH1 nuc

<400>  100
ggtggctcct tcagcagtgg aagttactcc                                        30


<210>  101
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  RVC20 CDRH2 nuc

<400>  101
atctattaca gtgggagcac t                                                 21


<210>  102
<211>  48
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  RVC20 CDRH3 nuc

<400>  102
gcgagaggca cgtattccga tttttggagt ggttcccctt tagactac                    48


<210>  103
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  RVC20 CDRL1 nuc

<400>  103
cagggcatta gcaattat                                                     18


<210>  104

<400>  104
000

<210>  105
<211>  27
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  RVC20 CDRL2 long nuc

<400>  105
ctgatctatg ctgcatccag tttgcaa                                           27


<210>  106
<211>  27
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  RVC20 CDRL3 nuc

<400>  106
caacagtatg atacttaccc tctcact                                           27


<210>  107
<211>  124
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  RVC20 heavy chain aa

<400>  107

Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Gln 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Gly Ser Phe Ser Ser Gly 
            20                  25                  30          


Ser Tyr Ser Trp Asn Trp Ile Arg Gln His Pro Gly Lys Gly Leu Glu 
        35                  40                  45              


Trp Ile Gly Tyr Ile Tyr Tyr Ser Gly Ser Thr Tyr Tyr Asn Pro Ser 
    50                  55                  60                  


Leu Lys Ser Arg Val Thr Met Ser Val His Thr Ser Lys Asn Gln Phe 
65                  70                  75                  80  


Ser Leu Lys Leu Asn Ser Ile Thr Ala Ala Asp Thr Ala Val Tyr Tyr 
                85                  90                  95      


Cys Ala Arg Gly Thr Tyr Ser Asp Phe Trp Ser Gly Ser Pro Leu Asp 
            100                 105                 110         


Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 


<210>  108
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  RVC20 light chain aa

<400>  108

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Ser Asn Tyr 
            20                  25                  30          


Leu Ala Trp Phe Gln Gln Lys Pro Gly Lys Ala Pro Lys Ser Leu Ile 
        35                  40                  45              


Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Asn Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Val Thr Tyr Phe Cys Gln Gln Tyr Asp Thr Tyr Pro Leu 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105         


<210>  109
<211>  373
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  RVC20 heavy chain nuc

<400>  109
caggtgcagc tgcaggagtc gggcccagga ctggtgaagc cttcacagac cctgtccctc       60

acctgcactg tctccggtgg ctccttcagc agtggaagtt actcctggaa ctggatccgc      120

cagcacccag ggaagggcct ggagtggatt gggtacatct attacagtgg gagcacttat      180

tacaacccgt ccctcaagag tcgagttacc atgtcagtac acacgtctaa gaaccagttc      240

tccctgaagc tgaactctat aactgccgcg gacacggccg tgtattactg tgcgagaggc      300

acgtattccg atttttggag tggttcccct ttagactact ggggccaggg aaccctggtc      360

accgtctcct cag                                                         373


<210>  110
<211>  322
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  RVC20 light chain nuc

<400>  110
gacatccaga tgacccagtc tccatcctca ctgtctgcat ctgtaggaga cagagtcacc       60

atcacttgtc gggcgagtca gggcattagc aattatttag cctggtttca gcagaaacca      120

gggaaagccc ctaagtccct gatctatgct gcatccagtt tgcaaagtgg ggtcccatca      180

aggttcagcg gcagtggatc tgggacagat ttcactctca ccatcaacag cctgcagcct      240

gaagattttg taacttattt ctgccaacag tatgatactt accctctcac tttcggcgga      300

gggaccaagg tggagatcaa ac                                               322


<210>  111
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  RVC21 CDRH1 aa

<400>  111

Gly Gly Ser Ile Ser Asn Pro Asn Tyr Tyr 
1               5                   10  


<210>  112
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  RVC21 CDRH2 aa

<400>  112

Ile Tyr Tyr Asn Gly Tyr Thr 
1               5           


<210>  113
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  RVC21 CDRH3 aa

<400>  113

Ala Thr Gln Ser Thr Met Thr Thr Ile Ala Gly His Tyr 
1               5                   10              


<210>  114
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  RVC21 CDRL1 aa

<400>  114

Thr Ser Asn Ile Gly Asn Ser Tyr 
1               5               


<210>  115

<400>  115
000

<210>  116
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  RVC21 CDRL2 long aa

<400>  116

Leu Ile Tyr Asp Asn Asn Lys Arg Pro 
1               5                   


<210>  117
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  RVC21 CDRL3 aa

<400>  117

Gly Thr Trp Asp Ser Ser Leu Asn Ala Tyr Val 
1               5                   10      


<210>  118
<211>  30
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  RVC21 CDRH1 nuc

<400>  118
ggtggctcca tcagcaaccc taactactac                                        30


<210>  119
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  RVC21 CDRH2 nuc

<400>  119
atctattata atgggtacac c                                                 21


<210>  120
<211>  39
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  RVC21 CDRH3 nuc

<400>  120
gcgacgcaat ctacgatgac taccatagcg ggccactac                              39


<210>  121
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  RVC21 CDRL1 nuc

<400>  121
acatccaaca ttgggaattc ttat                                              24


<210>  122

<400>  122
000

<210>  123
<211>  27
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  RVC21 CDRL2 long nuc

<400>  123
ctcatttatg acaataataa gcgaccc                                           27


<210>  124
<211>  33
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  RVC21 CDRL3 nuc

<400>  124
ggaacatggg acagcagcct gaatgcttat gtc                                    33


<210>  125
<211>  121
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  RVC21 heavy chain aa

<400>  125

Gln Leu Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Gly Ser Ile Ser Asn Pro 
            20                  25                  30          


Asn Tyr Tyr Trp Gly Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu 
        35                  40                  45              


Trp Ile Gly Ser Ile Tyr Tyr Asn Gly Tyr Thr Tyr Tyr Asn Pro Ser 
    50                  55                  60                  


Leu Lys Ser Arg Val Thr Ile Ser Val Asp Lys Ser Lys Asp Gln Phe 
65                  70                  75                  80  


Phe Leu Lys Met Thr Ser Leu Thr Ala Ala Asp Thr Ala Val Tyr Tyr 
                85                  90                  95      


Cys Ala Thr Gln Ser Thr Met Thr Thr Ile Ala Gly His Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120     


<210>  126
<211>  110
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  RVC21 light chain aa

<400>  126

Gln Ser Val Leu Thr Gln Ala Pro Ser Val Ser Ala Ala Pro Gly Leu 
1               5                   10                  15      


Lys Val Thr Ile Ser Cys Ser Gly Ser Thr Ser Asn Ile Gly Asn Ser 
            20                  25                  30          


Tyr Val Ser Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 
        35                  40                  45              


Ile Tyr Asp Asn Asn Lys Arg Pro Ser Gly Ile Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Lys Ser Asp Thr Ser Ala Thr Leu Gly Ile Thr Gly Leu Gln 
65                  70                  75                  80  


Thr Gly Asp Glu Ala Asp Tyr Tyr Cys Gly Thr Trp Asp Ser Ser Leu 
                85                  90                  95      


Asn Ala Tyr Val Phe Gly Thr Gly Thr Lys Val Thr Val Leu 
            100                 105                 110 


<210>  127
<211>  364
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  RVC21 heavy chain nuc

<400>  127
cagctgcagc tgcaggagtc gggcccagga ctggtgaagc cttcggagac cctgtccctc       60

acgtgcactg tctctggtgg ctccatcagc aaccctaact actactgggg ctggatccgc      120

cagcccccag ggaagggtct ggaatggatt gggagtatct attataatgg gtacacctac      180

tacaacccgt ccctcaagag tcgagttacc atatccgtgg acaagtccaa ggaccagttc      240

tttctgaaga tgacctctct gaccgccgca gacacggctg tgtattactg tgcgacgcaa      300

tctacgatga ctaccatagc gggccactac tggggccagg gaaccctggt caccgtctcc      360

tcag                                                                   364


<210>  128
<211>  331
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  RVC21 light chain nuc

<400>  128
cagtctgtat tgacgcaggc gccctcagtg tctgcggccc caggactaaa ggtcaccatc       60

tcctgctctg gaagcacatc caacattggg aattcttatg tatcctggta ccagcagctc      120

ccaggaacag cccccaaact cctcatttat gacaataata agcgaccctc agggattcct      180

gaccgattct ctggctccaa gtctgacacg tcagccaccc tgggcatcac cggactccag      240

actggggacg aggccgatta ttactgcgga acatgggaca gcagcctgaa tgcttatgtc      300

ttcggaactg ggaccaaggt caccgtccta g                                     331


<210>  129
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  RVC38 CDRH1 aa

<400>  129

Gly Gly Thr Phe Ser Ser Tyr Ala 
1               5               


<210>  130
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  RVC38 CDRH2 aa

<400>  130

Ile Met Pro Met Phe Val Ala Ala 
1               5               


<210>  131
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  RVC38 CDRH3 aa

<400>  131

Ala Arg Gly Asp Gly Tyr Asn Tyr Lys Trp Tyr Phe Asp Leu 
1               5                   10                  


<210>  132
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  RVC38 CDRL1 aa

<400>  132

Gln Asp Ile Ser Asn Tyr 
1               5       


<210>  133

<400>  133
000

<210>  134
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  RVC38 CDRL2 long aa

<400>  134

Leu Ile Tyr Ala Ala Ser Thr Leu Gln 
1               5                   


<210>  135
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  RVC38 CDRL3 aa

<400>  135

Gln Gln Leu Asp Thr Tyr Val Ala Leu Thr 
1               5                   10  


<210>  136
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  RVC38 CDRH1 nuc

<400>  136
ggaggcacct tcagcagcta tgcc                                              24


<210>  137
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  RVC38 CDRH2 nuc

<400>  137
atcatgccta tgtttgtggc ggca                                              24


<210>  138
<211>  42
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  RVC38 CDRH3 nuc

<400>  138
gcgagagggg atggctacaa ttacaagtgg tattttgacc tt                          42


<210>  139
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  RVC38 CDRL1 nuc

<400>  139
caggacatta gtaattat                                                     18


<210>  140

<400>  140
000

<210>  141
<211>  27
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  RVC38 CDRL2 long nuc

<400>  141
ctgatctatg ctgcatccac tttgcaa                                           27


<210>  142
<211>  30
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  RVC38 CDRL3 nuc

<400>  142
caacagcttg atacttacgt cgcgctcact                                        30


<210>  143
<211>  121
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  RVC38 heavy chain aa

<400>  143

Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Arg Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Ile Ser Trp Val Arg Gln Ala Pro Gly Leu Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Gly Ile Met Pro Met Phe Val Ala Ala Asn Tyr Ala Gln Asn Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Val Ser Val Asp Lys Ser Thr Asn Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Met His Asn Leu Arg Ser Asp Asp Thr Ala Met Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Asp Gly Tyr Asn Tyr Lys Trp Tyr Phe Asp Leu Trp Gly 
            100                 105                 110         


Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120     


<210>  144
<211>  108
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  RVC38 light chain aa

<400>  144

Asp Ile Gln Leu Thr Gln Ser Pro Ser Phe Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Asp Ile Ser Asn Tyr 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Pro Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ala Ala Ser Thr Leu Gln Arg Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Ser Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Leu Asp Thr Tyr Val Ala 
                85                  90                  95      


Leu Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105             


<210>  145
<211>  364
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  RVC38 heavy chain nuc

<400>  145
gaggtgcagc tggtgcagtc tggggctgag gtgaagaagc ctgggtcctc ggtgagggtc       60

tcctgcaagg cttctggagg caccttcagc agctatgcca tcagctgggt gcgacaggcc      120

cctgggctag ggcttgagtg gatgggaggg atcatgccta tgtttgtggc ggcaaactac      180

gcacagaact tccagggcag agtcacggtt tctgtggaca aatccacgaa caccgcctat      240

atggagatgc acaacctgag atctgacgac acggccatgt attactgtgc gagaggggat      300

ggctacaatt acaagtggta ttttgacctt tggggccagg gaaccctagt caccgtctcc      360

tcag                                                                   364


<210>  146
<211>  325
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  RVC38 light chain nuc

<400>  146
gacatccagt tgacccagtc tccatccttc ctgtctgcat ctgtaggaga cagagtcacc       60

atcacttgcc gggccagtca ggacattagt aattatttag cctggtatca gcaaaaacca      120

gggaagcccc ctaaactcct gatctatgct gcatccactt tgcaaagggg ggtcccatca      180

aggttcagtg gcagtggatc tgggtcagaa ttcactctca caatcagcag cctgcagcct      240

gaagattttg caacttatta ctgtcaacag cttgatactt acgtcgcgct cactttcggc      300

ggagggacca aggtggagat caaac                                            325


<210>  147
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  RVC44 CDRH1 aa

<400>  147

Gly Phe Thr Phe Ser Ser Tyr Ser 
1               5               


<210>  148
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  RVC44 CDRH2 aa

<400>  148

Ile Ser Thr Thr Gly Thr Tyr Ile 
1               5               


<210>  149
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  RVC44 CDRH3 aa

<400>  149

Ala Arg Arg Ser Ala Ile Ala Leu Ala Gly Thr Gln Arg Ala Phe Asp 
1               5                   10                  15      


Ile 
    


<210>  150
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  RVC44 CDRL1 aa

<400>  150

Gln Asn Ile Asn Asn Tyr 
1               5       


<210>  151

<400>  151
000

<210>  152
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  RVC44 CDRL2 long aa

<400>  152

Leu Ile Tyr Ala Ala Ser Ser Leu His 
1               5                   


<210>  153
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  RVC44 CDRL3 aa

<400>  153

Gln Gln Ser Tyr Ser Asn Pro Trp Thr 
1               5                   


<210>  154
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  RVC44 CDRH1 nuc

<400>  154
ggcttcacct ttagtagtta tagt                                              24


<210>  155
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  RVC44 CDRH2 nuc

<400>  155
atcagtacta ctggtactta cata                                              24


<210>  156
<211>  51
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  RVC44 CDRH3 nuc

<400>  156
gcgagacggt cggccatagc actggctggt acgcagcgtg cttttgatat c                51


<210>  157
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  RVC44 CDRL1 nuc

<400>  157
cagaacatta acaactat                                                     18


<210>  158

<400>  158
000

<210>  159
<211>  27
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  RVC44 CDRL2 long nuc

<400>  159
ctgatctatg ctgcatccag tttacat                                           27


<210>  160
<211>  27
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  RVC44 CDRL3 nuc

<400>  160
caacagagtt acagtaaccc ttggacg                                           27


<210>  161
<211>  124
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  RVC44 heavy chain aa

<400>  161

Glu Val Gln Leu Val Gln Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ser Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ser Ile Ser Thr Thr Gly Thr Tyr Ile Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Glu Gly Arg Phe Ser Ile Ser Arg Asp Ser Ala Arg Ser Ser Leu Phe 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Arg Ser Ala Ile Ala Leu Ala Gly Thr Gln Arg Ala Phe Asp 
            100                 105                 110         


Ile Trp Gly Pro Gly Thr Asn Val Ile Val Ser Ser 
        115                 120                 


<210>  162
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  RVC44 light chain aa

<400>  162

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Asn Ile Asn Asn Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Leu Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ala Ala Ser Ser Leu His Ser Gly Val Pro Ser Arg Phe Ser Ala 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Ile Leu Thr Ile Ser Asn Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Cys Ala Thr Tyr Tyr Cys Gln Gln Ser Tyr Ser Asn Pro Trp 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105         


<210>  163
<211>  373
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  RVC44 heavy chain nuc

<400>  163
gaggtgcagc tggtgcagtc tgggggaggc ctggtcaagc ctggggggtc cctgagactc       60

tcctgtgcag cctctggctt cacctttagt agttatagta tgagttgggt ccgccaggct      120

ccagggaagg gcctggagtg ggtctcatcc atcagtacta ctggtactta catatactac      180

gcagactcag tggagggccg attctccatt tccagagaca gcgccaggag ctctctgttt      240

ctgcaaatga acagcctgag agccgaggac acggctgtct attactgtgc gagacggtcg      300

gccatagcac tggctggtac gcagcgtgct tttgatatct ggggcccagg gacaaacgtc      360

atcgtctctt cag                                                         373


<210>  164
<211>  322
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  RVC44 light chain nuc

<400>  164
gacatccaga tgacccagtc tccatcttcc ctgtctgcat ctgtaggaga cagagtcacc       60

atcacttgcc gggcaagtca gaacattaac aactatttaa attggtatca gcagaaacta      120

gggaaagccc ctaagctcct gatctatgct gcatccagtt tacatagtgg ggtcccatca      180

aggttcagtg ccagtggatc tgggacagat ttcattctga ccatcagtaa tctgcaacct      240

gaagattgtg caacttacta ctgtcaacag agttacagta acccttggac gttcggccaa      300

gggaccaagg tggaaatcaa ac                                               322


<210>  165
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  RVC58 CDRH1 aa

<400>  165

Gly Phe Thr Phe Ser Thr Tyr Ala 
1               5               


<210>  166
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  RVC58 CDRH2 aa

<400>  166

Ile Ser Asp Arg Gly Gly Ser Arg 
1               5               


<210>  167
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  RVC58 CDRH3 aa

<400>  167

Ala Arg Asp Ile Ala Pro Pro Tyr Asn Tyr Tyr Phe Tyr Gly Met Asp 
1               5                   10                  15      


Val 
    


<210>  168
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  RVC58 CDRL1 aa

<400>  168

Ser Ser Asp Ile Gly Ala Phe Asn Tyr 
1               5                   


<210>  169

<400>  169
000

<210>  170
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  RVC58 CDRL2 long aa

<400>  170

Ile Ile Tyr Glu Val Ser Asn Arg Pro 
1               5                   


<210>  171
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  RVC58 CDRL3 aa

<400>  171

Asn Ser Tyr Thr Ser Ser Ser Thr Gln Leu 
1               5                   10  


<210>  172
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  RVC58 CDRH1 nuc

<400>  172
ggattcacct ttagcaccta tgcc                                              24


<210>  173
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  RVC58 CDRH2 nuc

<400>  173
attagtgata gaggtggtag taga                                              24


<210>  174
<211>  51
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  RVC58 CDRH3 nuc

<400>  174
gcgagagata ttgccccccc atataactac tacttctacg gtatggacgt c                51


<210>  175
<211>  27
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  RVC58 CDRL1 nuc

<400>  175
agcagtgaca ttggtgcttt taactat                                           27


<210>  176

<400>  176
000

<210>  177
<211>  27
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  RVC58 CDRL2 long nuc

<400>  177
ataatttatg aggtcagtaa tcggccc                                           27


<210>  178
<211>  30
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  RVC58 CDRL3 nuc

<400>  178
aactcatata caagcagcag cactcagtta                                        30


<210>  179
<211>  124
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  RVC58 heavy chain aa

<400>  179

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Thr Tyr 
            20                  25                  30          


Ala Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Gly Ile Ser Asp Arg Gly Gly Ser Arg Tyr Tyr Ala Gly Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Phe 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Ile Ala Pro Pro Tyr Asn Tyr Tyr Phe Tyr Gly Met Asp 
            100                 105                 110         


Val Trp Gly Arg Gly Thr Thr Val Thr Val Ser Ser 
        115                 120                 


<210>  180
<211>  110
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  RVC58 light chain aa

<400>  180

Gln Ser Ala Leu Thr Gln Pro Ala Ser Val Ser Gly Ser Pro Gly Gln 
1               5                   10                  15      


Ser Ile Thr Ile Ser Cys Thr Gly Thr Ser Ser Asp Ile Gly Ala Phe 
            20                  25                  30          


Asn Tyr Val Ser Trp Tyr Gln Gln His Pro Gly Lys Ala Pro Lys Leu 
        35                  40                  45              


Ile Ile Tyr Glu Val Ser Asn Arg Pro Ser Gly Val Ser Asn Arg Phe 
    50                  55                  60                  


Ser Gly Ser Lys Ser Gly Asn Thr Ala Ser Leu Thr Ile Ser Gly Leu 
65                  70                  75                  80  


Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Asn Ser Tyr Thr Ser Ser 
                85                  90                  95      


Ser Thr Gln Leu Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105                 110 


<210>  181
<211>  373
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  RVC58 heavy chain nuc

<400>  181
gaggtgcagc tggtggagtc tgggggaggc ttggtacagc ctggggggtc cctgagactc       60

tcctgtgcgg cctctggatt cacctttagc acctatgcca tgaattgggt ccgccaggct      120

ccagggaagg ggctggagtg ggtctcaggt attagtgata gaggtggtag tagatactac      180

gcaggctccg tgaagggccg gttcaccatc tccagagaca attccaagaa cacgctgttt      240

ctgcaaatga acagcctgag agccgaggac acggccgtat attactgtgc gagagatatt      300

gcccccccat ataactacta cttctacggt atggacgtct ggggccgagg gaccacggtc      360

accgtctcct cag                                                         373


<210>  182
<211>  331
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  RVC58 light chain nuc

<400>  182
cagtctgccc tgactcagcc tgcctccgtg tctgggtctc ctggacagtc gatcaccatc       60

tcctgcactg gtaccagcag tgacattggt gcttttaact atgtctcttg gtaccaacag      120

cacccaggca aagcccccaa actcataatt tatgaggtca gtaatcggcc ctcaggggtt      180

tctaatcgct tctctggctc caagtctggc aacacggcct ccctgaccat ctctgggctc      240

caggctgagg acgaggctga ttattactgc aactcatata caagcagcag cactcagtta      300

ttcggcggag ggaccaagct gaccgtccta g                                     331


<210>  183
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  RVC68 CDRH1 aa

<400>  183

Gly Gly Ser Ile Ser Glu His His 
1               5               


<210>  184
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  RVC68 CDRH2 aa

<400>  184

Ile Phe His Ser Gly Ser Thr 
1               5           


<210>  185
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  RVC68 CDRH3 aa

<400>  185

Ala Arg Ala Val Ser Thr Tyr Tyr Tyr Tyr Tyr Ile Asp Val 
1               5                   10                  


<210>  186
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  RVC68 CDRL1 aa

<400>  186

Gln Asp Ile Ser Asn Trp 
1               5       


<210>  187

<400>  187
000

<210>  188
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  RVC68 CDRL2 long aa

<400>  188

Leu Ile Tyr Ala Ala Ser Ser Leu Gln 
1               5                   


<210>  189
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  RVC68 CDRL3 aa

<400>  189

Gln Gln Ala Lys Ser Phe Pro Leu Thr 
1               5                   


<210>  190
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  RVC68 CDRH1 nuc

<400>  190
ggtggctcca ttagtgagca ccac                                              24


<210>  191
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  RVC68 CDRH2 nuc

<400>  191
atctttcaca gtgggagtac c                                                 21


<210>  192
<211>  42
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  RVC68 CDRH3 nuc

<400>  192
gcgagagcgg tgtctactta ctactactat tacatagacg tc                          42


<210>  193
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  RVC68 CDRL1 nuc

<400>  193
caggatatta gcaactgg                                                     18


<210>  194

<400>  194
000

<210>  195
<211>  27
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  RVC68 CDRL2 long nuc

<400>  195
ctgatctatg ctgcgtccag tttgcaa                                           27


<210>  196
<211>  27
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  RVC68 CDRL3 nuc

<400>  196
caacaggcta agagtttccc tcttact                                           27


<210>  197
<211>  120
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  RVC68 heavy chain aa

<400>  197

Gln Val Gln Leu Gln Glu Ser Gly Pro Arg Leu Val Lys Pro Ser Glu 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Phe Ser Gly Gly Ser Ile Ser Glu His 
            20                  25                  30          


His Trp Ser Trp Leu Arg Gln Ser Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Tyr Ile Phe His Ser Gly Ser Thr Asn Tyr Asn Pro Ser Leu Lys 
    50                  55                  60                  


Ser Arg Val Asn Ile Ser Leu Asp Lys Ser Lys Asn Gln Phe Ser Leu 
65                  70                  75                  80  


Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Phe Cys Ala 
                85                  90                  95      


Arg Ala Val Ser Thr Tyr Tyr Tyr Tyr Tyr Ile Asp Val Trp Gly Gln 
            100                 105                 110         


Gly Thr Thr Val Thr Val Ser Ser 
        115                 120 


<210>  198
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  RVC68 light chain aa

<400>  198

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Val Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Asp Ile Ser Asn Trp 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ala Ala Ser Ser Leu Gln Ser Gly Ile Ser Ser Arg Phe Ser Gly 
    50                  55                  60                  


Gly Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Ser Tyr Tyr Cys Gln Gln Ala Lys Ser Phe Pro Leu 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105         


<210>  199
<211>  361
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  RVC68 heavy chain nuc

<400>  199
caggtgcagc tacaggagtc gggcccaaga ctggtgaagc cctcggagac cctgtccctc       60

acctgcactt tctctggtgg ctccattagt gagcaccact ggagctggct ccggcagtcc      120

ccagggaagg gactggagtg gattggatat atctttcaca gtgggagtac caactacaac      180

ccctccctca agagtcgagt caacatatca ttagacaagt ccaagaacca gttctccctg      240

aagctgagtt ctgtgaccgc tgcggacacg gccgtgtatt tctgtgcgag agcggtgtct      300

acttactact actattacat agacgtctgg ggccaaggga ccacggtcac cgtctcctca      360

g                                                                      361


<210>  200
<211>  322
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  RVC68 light chain nuc

<400>  200
gacatccaga tgacccagtc tccatcttcc gtgtctgcat ctgtaggaga cagagtcacc       60

atcacttgtc gggcgagtca ggatattagc aactggttag cctggtatca gcagaaacca      120

gggaaagccc ctaaactcct gatctatgct gcgtccagtt tgcaaagtgg gatctcatct      180

aggttcagcg gcggtggctc tgggacagat ttcactctca ccatcagcag cctgcagcct      240

gaagattttg caagttacta ctgtcaacag gctaagagtt tccctcttac ttttggccag      300

gggaccaagc tggagatcaa ac                                               322


<210>  201
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  RVC111 CDRH1 aa

<400>  201

Gly Phe Ser Phe Ser Ser Tyr Val 
1               5               


<210>  202
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  RVC111 CDRH2 aa

<400>  202

Ile Ser Tyr Asp Gly Ser Asn Lys 
1               5               


<210>  203
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  RVC111 CDRH3 aa

<400>  203

Ala Arg Gly Ser Gly Thr Gln Thr Pro Leu Phe Asp Tyr 
1               5                   10              


<210>  204
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  RVC111 CDRL1 aa

<400>  204

Gln Ser Ile Thr Ser Trp 
1               5       


<210>  205

<400>  205
000

<210>  206
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  RVC111 CDRL2 long aa

<400>  206

Leu Ile Tyr Asp Asp Ser Thr Leu Glu 
1               5                   


<210>  207
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  RVC111 CDRL3 aa

<400>  207

Gln Gln Tyr Glu Ser Tyr Ser Gly Thr 
1               5                   


<210>  208
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  RVC111 CDRH1 nuc

<400>  208
ggattctcct tcagtagcta tgtt                                              24


<210>  209
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  RVC111 CDRH2 nuc

<400>  209
atatcatatg atggaagtaa taaa                                              24


<210>  210
<211>  39
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  RVC111 CDRH3 nuc

<400>  210
gcgagagggt ccggaaccca aactcccctc tttgactac                              39


<210>  211
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  RVC111 CDRL1 nuc

<400>  211
cagagtatta ctagctgg                                                     18


<210>  212

<400>  212
000

<210>  213
<211>  27
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  RVC111 CDRL2 long nuc

<400>  213
ctgatctatg atgactccac tttggaa                                           27


<210>  214
<211>  27
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  RVC111 CDRL3 nuc

<400>  214
caacagtatg agagttattc agggacg                                           27


<210>  215
<211>  120
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  RVC111 heavy chain aa

<400>  215

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Ser Phe Ser Ser Tyr 
            20                  25                  30          


Val Met Tyr Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Thr Ile Ile Ser Tyr Asp Gly Ser Asn Lys Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Ser Gly Thr Gln Thr Pro Leu Phe Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser 
        115                 120 


<210>  216
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  RVC111 light chain aa

<400>  216

Asp Ile Gln Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Asn Gln Ser Ile Thr Ser Trp 
            20                  25                  30          


Val Ala Trp Tyr Gln Gln Met Pro Gly Arg Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Asp Asp Ser Thr Leu Glu Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Asp Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Glu Ser Tyr Ser Gly 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105         


<210>  217
<211>  361
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  RVC111 heavy chain nuc

<400>  217
caggtgcaac tggtggagtc tgggggaggc gtggtccagc ctgggaggtc cctgagactc       60

tcctgtgcag cctctggatt ctccttcagt agctatgtta tgtactgggt ccgccaggct      120

ccaggcaagg ggctggagtg ggtgacaatt atatcatatg atggaagtaa taaatactac      180

gcagactccg tgaagggccg attcaccatc tccagagaca attccaagaa cacgctgtat      240

ctgcaaatga acagcctgag agctgaggac acggctgtct attactgtgc gagagggtcc      300

ggaacccaaa ctcccctctt tgactactgg ggccagggaa ccctggtcac cgtctcctca      360

g                                                                      361


<210>  218
<211>  322
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  RVC111 light chain nuc

<400>  218
gacatccaga tgacccagtc tccttccacc ctgtctgcat ctgtgggaga cagagtcacc       60

atcacttgcc gggccaatca gagtattact agctgggtgg cctggtatca gcagatgcca      120

gggagagccc ctaaactcct gatctatgat gactccactt tggaaagtgg ggtcccatca      180

aggttcagcg gcagtggatc tgggacagaa ttcactctca ccatcagcag cctgcagcct      240

gatgattttg caacttatta ctgccaacag tatgagagtt attcagggac gttcggccaa      300

gggaccaagg tggaaatcaa ac                                               322


<210>  219
<211>  330
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IgG1 CH1-CH2-CH3 LALA aa

<400>  219

Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys 
1               5                   10                  15      


Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
            20                  25                  30          


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        35                  40                  45              


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  


Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr 
65                  70                  75                  80  


Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys 
                85                  90                  95      


Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys 
            100                 105                 110         


Pro Ala Pro Glu Ala Ala Gly Gly Pro Ser Val Phe Leu Phe Pro Pro 
        115                 120                 125             


Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys 
    130                 135                 140                 


Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp 
145                 150                 155                 160 


Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu 
                165                 170                 175     


Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu 
            180                 185                 190         


His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn 
        195                 200                 205             


Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly 
    210                 215                 220                 


Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu 
225                 230                 235                 240 


Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr 
                245                 250                 255     


Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn 
            260                 265                 270         


Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe 
        275                 280                 285             


Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn 
    290                 295                 300                 


Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr 
305                 310                 315                 320 


Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
                325                 330 


<210>  220
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IgG CK aa

<400>  220

Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu 
1               5                   10                  15      


Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe 
            20                  25                  30          


Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln 
        35                  40                  45              


Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser 
    50                  55                  60                  


Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu 
65                  70                  75                  80  


Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser 
                85                  90                  95      


Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
            100                 105         


<210>  221
<211>  106
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IgG CL aa

<400>  221

Gly Gln Pro Lys Ala Ala Pro Ser Val Thr Leu Phe Pro Pro Ser Ser 
1               5                   10                  15      


Glu Glu Leu Gln Ala Asn Lys Ala Thr Leu Val Cys Leu Ile Ser Asp 
            20                  25                  30          


Phe Tyr Pro Gly Ala Val Thr Val Ala Trp Lys Ala Asp Ser Ser Pro 
        35                  40                  45              


Val Lys Ala Gly Val Glu Thr Thr Thr Pro Ser Lys Gln Ser Asn Asn 
    50                  55                  60                  


Lys Tyr Ala Ala Ser Ser Tyr Leu Ser Leu Thr Pro Glu Gln Trp Lys 
65                  70                  75                  80  


Ser His Arg Ser Tyr Ser Cys Gln Val Thr His Glu Gly Ser Thr Val 
                85                  90                  95      


Glu Lys Thr Val Ala Pro Thr Glu Cys Ser 
            100                 105     


<210>  222
<211>  990
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  IgG1 CH1-CH2-CH3 LALA nucl

<400>  222
gcgtcgacca agggcccatc ggtcttcccc ctggcaccct cctccaagag cacctctggg       60

ggcacagcgg ccctgggctg cctggtcaag gactacttcc ccgaacctgt gacggtctcg      120

tggaactcag gcgccctgac cagcggcgtg cacaccttcc cggctgtcct acagtcctca      180

ggactctact ccctcagcag cgtggtgacc gtgccctcca gcagcttggg cacccagacc      240

tacatctgca acgtgaatca caagcccagc aacaccaagg tggacaagag agttgagccc      300

aaatcttgtg acaaaactca cacatgccca ccgtgcccag cacctgaagc cgcgggggga      360

ccgtcagtct tcctcttccc cccaaaaccc aaggacaccc tcatgatctc ccggacccct      420

gaggtcacat gcgtggtggt ggacgtgagc cacgaagacc ctgaggtcaa gttcaactgg      480

tacgtggacg gcgtggaggt gcataatgcc aagacaaagc cgcgggagga gcagtacaac      540

agcacgtacc gtgtggtcag cgtcctcacc gtcctgcacc aggactggct gaatggcaag      600

gagtacaagt gcaaggtctc caacaaagcc ctcccagccc ccatcgagaa aaccatctcc      660

aaagccaaag ggcagccccg agaaccacag gtgtacaccc tgcccccatc ccgggaggag      720

atgaccaaga accaggtcag cctgacctgc ctggtcaaag gcttctatcc cagcgacatc      780

gccgtggagt gggagagcaa tgggcagccg gagaacaact acaagaccac gcctcccgtg      840

ctggactccg acggctcctt cttcctctat agcaagctca ccgtggacaa gagcaggtgg      900

cagcagggga acgtcttctc atgctccgtg atgcatgagg ctctgcacaa ccactacacg      960

cagaagagcc tctccctgtc cccgggtaaa                                       990


<210>  223
<211>  321
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  IgG CK nucl

<400>  223
cgtacggtgg ctgcaccatc tgtcttcatc ttcccgccat ctgatgagca gttgaaatct       60

ggaactgcct ctgttgtgtg cctgctgaat aacttctatc ccagagaggc caaagtacag      120

tggaaggtgg ataacgccct ccaatcgggt aactcccagg agagtgtcac agagcaggac      180

agcaaggaca gcacctacag cctcagcagc accctgacgc tgagcaaagc agactacgag      240

aaacacaaag tctacgcctg cgaagtcacc catcagggcc tgagctcgcc cgtcacaaag      300

agcttcaaca ggggagagtg t                                                321


<210>  224
<211>  318
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  IgG CL nucl

<400>  224
ggtcagccca aggctgcccc ctcggtcact ctgttcccgc cctcctctga ggagcttcaa       60

gccaacaagg ccacactggt gtgtctcata agtgacttct acccgggagc cgtgacagtg      120

gcttggaaag cagatagcag ccccgtcaag gcgggagtgg agaccaccac accctccaaa      180

caaagcaaca acaagtacgc ggccagcagc tatctgagcc tgacgcctga gcagtggaag      240

tcccacagaa gctacagctg ccaggtcacg catgaaggga gcaccgtgga gaagacagtg      300

gcccctacag aatgttca                                                    318


<210>  225
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  225
ctgacgtagc actggcagac                                                   20


<210>  226
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  226
agtcgacctc cgttcatcat                                                   20


