                         SEQUENCE LISTING

<110>  FUNDACION DEL SECTOR PBLICO ESTATAL CENTRO NACIONAL DE 
       INVESTIGACIONES ONCOLGICAS CARLOS III (F.S.P. CNIO)
 
<120>  GENE EDITING BASED CANCER TREATMENT

<130>  PCT-937

<150>  EP18382746
<151>  2018-10-18

<160>  165   

<170>  PatentIn version 3.5

<210>  1
<211>  1396
<212>  PRT
<213>  Streptococcus pyogenes

<400>  1

Met Pro Lys Lys Lys Arg Lys Val Gly Val Pro Ala Ala Asp Lys Lys 
1               5                   10                  15      


Tyr Ser Ile Gly Leu Asp Ile Gly Thr Asn Ser Val Gly Trp Ala Val 
            20                  25                  30          


Ile Thr Asp Glu Tyr Lys Val Pro Ser Lys Lys Phe Lys Val Leu Gly 
        35                  40                  45              


Asn Thr Asp Arg His Ser Ile Lys Lys Asn Leu Ile Gly Ala Leu Leu 
    50                  55                  60                  


Phe Asp Ser Gly Glu Thr Ala Glu Ala Thr Arg Leu Lys Arg Thr Ala 
65                  70                  75                  80  


Arg Arg Arg Tyr Thr Arg Arg Lys Asn Arg Ile Cys Tyr Leu Gln Glu 
                85                  90                  95      


Ile Phe Ser Asn Glu Met Ala Lys Val Asp Asp Ser Phe Phe His Arg 
            100                 105                 110         


Leu Glu Glu Ser Phe Leu Val Glu Glu Asp Lys Lys His Glu Arg His 
        115                 120                 125             


Pro Ile Phe Gly Asn Ile Val Asp Glu Val Ala Tyr His Glu Lys Tyr 
    130                 135                 140                 


Pro Thr Ile Tyr His Leu Arg Lys Lys Leu Val Asp Ser Thr Asp Lys 
145                 150                 155                 160 


Ala Asp Leu Arg Leu Ile Tyr Leu Ala Leu Ala His Met Ile Lys Phe 
                165                 170                 175     


Arg Gly His Phe Leu Ile Glu Gly Asp Leu Asn Pro Asp Asn Ser Asp 
            180                 185                 190         


Val Asp Lys Leu Phe Ile Gln Leu Val Gln Thr Tyr Asn Gln Leu Phe 
        195                 200                 205             


Glu Glu Asn Pro Ile Asn Ala Ser Gly Val Asp Ala Lys Ala Ile Leu 
    210                 215                 220                 


Ser Ala Arg Leu Ser Lys Ser Arg Arg Leu Glu Asn Leu Ile Ala Gln 
225                 230                 235                 240 


Leu Pro Gly Glu Lys Lys Asn Gly Leu Phe Gly Asn Leu Ile Ala Leu 
                245                 250                 255     


Ser Leu Gly Leu Thr Pro Asn Phe Lys Ser Asn Phe Asp Leu Ala Glu 
            260                 265                 270         


Asp Ala Lys Leu Gln Leu Ser Lys Asp Thr Tyr Asp Asp Asp Leu Asp 
        275                 280                 285             


Asn Leu Leu Ala Gln Ile Gly Asp Gln Tyr Ala Asp Leu Phe Leu Ala 
    290                 295                 300                 


Ala Lys Asn Leu Ser Asp Ala Ile Leu Leu Ser Asp Ile Leu Arg Val 
305                 310                 315                 320 


Asn Thr Glu Ile Thr Lys Ala Pro Leu Ser Ala Ser Met Ile Lys Arg 
                325                 330                 335     


Tyr Asp Glu His His Gln Asp Leu Thr Leu Leu Lys Ala Leu Val Arg 
            340                 345                 350         


Gln Gln Leu Pro Glu Lys Tyr Lys Glu Ile Phe Phe Asp Gln Ser Lys 
        355                 360                 365             


Asn Gly Tyr Ala Gly Tyr Ile Asp Gly Gly Ala Ser Gln Glu Glu Phe 
    370                 375                 380                 


Tyr Lys Phe Ile Lys Pro Ile Leu Glu Lys Met Asp Gly Thr Glu Glu 
385                 390                 395                 400 


Leu Leu Val Lys Leu Asn Arg Glu Asp Leu Leu Arg Lys Gln Arg Thr 
                405                 410                 415     


Phe Asp Asn Gly Ser Ile Pro His Gln Ile His Leu Gly Glu Leu His 
            420                 425                 430         


Ala Ile Leu Arg Arg Gln Glu Asp Phe Tyr Pro Phe Leu Lys Asp Asn 
        435                 440                 445             


Arg Glu Lys Ile Glu Lys Ile Leu Thr Phe Arg Ile Pro Tyr Tyr Val 
    450                 455                 460                 


Gly Pro Leu Ala Arg Gly Asn Ser Arg Phe Ala Trp Met Thr Arg Lys 
465                 470                 475                 480 


Ser Glu Glu Thr Ile Thr Pro Trp Asn Phe Glu Glu Val Val Asp Lys 
                485                 490                 495     


Gly Ala Ser Ala Gln Ser Phe Ile Glu Arg Met Thr Asn Phe Asp Lys 
            500                 505                 510         


Asn Leu Pro Asn Glu Lys Val Leu Pro Lys His Ser Leu Leu Tyr Glu 
        515                 520                 525             


Tyr Phe Thr Val Tyr Asn Glu Leu Thr Lys Val Lys Tyr Val Thr Glu 
    530                 535                 540                 


Gly Met Arg Lys Pro Ala Phe Leu Ser Gly Glu Gln Lys Lys Ala Ile 
545                 550                 555                 560 


Val Asp Leu Leu Phe Lys Thr Asn Arg Lys Val Thr Val Lys Gln Leu 
                565                 570                 575     


Lys Glu Asp Tyr Phe Lys Lys Ile Glu Cys Phe Asp Ser Val Glu Ile 
            580                 585                 590         


Ser Gly Val Glu Asp Arg Phe Asn Ala Ser Leu Gly Thr Tyr His Asp 
        595                 600                 605             


Leu Leu Lys Ile Ile Lys Asp Lys Asp Phe Leu Asp Asn Glu Glu Asn 
    610                 615                 620                 


Glu Asp Ile Leu Glu Asp Ile Val Leu Thr Leu Thr Leu Phe Glu Asp 
625                 630                 635                 640 


Arg Glu Met Ile Glu Glu Arg Leu Lys Thr Tyr Ala His Leu Phe Asp 
                645                 650                 655     


Asp Lys Val Met Lys Gln Leu Lys Arg Arg Arg Tyr Thr Gly Trp Gly 
            660                 665                 670         


Arg Leu Ser Arg Lys Leu Ile Asn Gly Ile Arg Asp Lys Gln Ser Gly 
        675                 680                 685             


Lys Thr Ile Leu Asp Phe Leu Lys Ser Asp Gly Phe Ala Asn Arg Asn 
    690                 695                 700                 


Phe Met Gln Leu Ile His Asp Asp Ser Leu Thr Phe Lys Glu Asp Ile 
705                 710                 715                 720 


Gln Lys Ala Gln Val Ser Gly Gln Gly Asp Ser Leu His Glu His Ile 
                725                 730                 735     


Ala Asn Leu Ala Gly Ser Pro Ala Ile Lys Lys Gly Ile Leu Gln Thr 
            740                 745                 750         


Val Lys Val Val Asp Glu Leu Val Lys Val Met Gly Arg His Lys Pro 
        755                 760                 765             


Glu Asn Ile Val Ile Glu Met Ala Arg Glu Asn Gln Thr Thr Gln Lys 
    770                 775                 780                 


Gly Gln Lys Asn Ser Arg Glu Arg Met Lys Arg Ile Glu Glu Gly Ile 
785                 790                 795                 800 


Lys Glu Leu Gly Ser Gln Ile Leu Lys Glu His Pro Val Glu Asn Thr 
                805                 810                 815     


Gln Leu Gln Asn Glu Lys Leu Tyr Leu Tyr Tyr Leu Gln Asn Gly Arg 
            820                 825                 830         


Asp Met Tyr Val Asp Gln Glu Leu Asp Ile Asn Arg Leu Ser Asp Tyr 
        835                 840                 845             


Asp Val Asp His Ile Val Pro Gln Ser Phe Leu Lys Asp Asp Ser Ile 
    850                 855                 860                 


Asp Asn Lys Val Leu Thr Arg Ser Asp Lys Asn Arg Gly Lys Ser Asp 
865                 870                 875                 880 


Asn Val Pro Ser Glu Glu Val Val Lys Lys Met Lys Asn Tyr Trp Arg 
                885                 890                 895     


Gln Leu Leu Asn Ala Lys Leu Ile Thr Gln Arg Lys Phe Asp Asn Leu 
            900                 905                 910         


Thr Lys Ala Glu Arg Gly Gly Leu Ser Glu Leu Asp Lys Ala Gly Phe 
        915                 920                 925             


Ile Lys Arg Gln Leu Val Glu Thr Arg Gln Ile Thr Lys His Val Ala 
    930                 935                 940                 


Gln Ile Leu Asp Ser Arg Met Asn Thr Lys Tyr Asp Glu Asn Asp Lys 
945                 950                 955                 960 


Leu Ile Arg Glu Val Lys Val Ile Thr Leu Lys Ser Lys Leu Val Ser 
                965                 970                 975     


Asp Phe Arg Lys Asp Phe Gln Phe Tyr Lys Val Arg Glu Ile Asn Asn 
            980                 985                 990         


Tyr His His Ala His Asp Ala Tyr  Leu Asn Ala Val Val  Gly Thr Ala 
        995                 1000                 1005             


Leu Ile  Lys Lys Tyr Pro Lys  Leu Glu Ser Glu Phe  Val Tyr Gly 
    1010                 1015                 1020             


Asp Tyr  Lys Val Tyr Asp Val  Arg Lys Met Ile Ala  Lys Ser Glu 
    1025                 1030                 1035             


Gln Glu  Ile Gly Lys Ala Thr  Ala Lys Tyr Phe Phe  Tyr Ser Asn 
    1040                 1045                 1050             


Ile Met  Asn Phe Phe Lys Thr  Glu Ile Thr Leu Ala  Asn Gly Glu 
    1055                 1060                 1065             


Ile Arg  Lys Arg Pro Leu Ile  Glu Thr Asn Gly Glu  Thr Gly Glu 
    1070                 1075                 1080             


Ile Val  Trp Asp Lys Gly Arg  Asp Phe Ala Thr Val  Arg Lys Val 
    1085                 1090                 1095             


Leu Ser  Met Pro Gln Val Asn  Ile Val Lys Lys Thr  Glu Val Gln 
    1100                 1105                 1110             


Thr Gly  Gly Phe Ser Lys Glu  Ser Ile Leu Pro Lys  Arg Asn Ser 
    1115                 1120                 1125             


Asp Lys  Leu Ile Ala Arg Lys  Lys Asp Trp Asp Pro  Lys Lys Tyr 
    1130                 1135                 1140             


Gly Gly  Phe Asp Ser Pro Thr  Val Ala Tyr Ser Val  Leu Val Val 
    1145                 1150                 1155             


Ala Lys  Val Glu Lys Gly Lys  Ser Lys Lys Leu Lys  Ser Val Lys 
    1160                 1165                 1170             


Glu Leu  Leu Gly Ile Thr Ile  Met Glu Arg Ser Ser  Phe Glu Lys 
    1175                 1180                 1185             


Asn Pro  Ile Asp Phe Leu Glu  Ala Lys Gly Tyr Lys  Glu Val Lys 
    1190                 1195                 1200             


Lys Asp  Leu Ile Ile Lys Leu  Pro Lys Tyr Ser Leu  Phe Glu Leu 
    1205                 1210                 1215             


Glu Asn  Gly Arg Lys Arg Met  Leu Ala Ser Ala Gly  Glu Leu Gln 
    1220                 1225                 1230             


Lys Gly  Asn Glu Leu Ala Leu  Pro Ser Lys Tyr Val  Asn Phe Leu 
    1235                 1240                 1245             


Tyr Leu  Ala Ser His Tyr Glu  Lys Leu Lys Gly Ser  Pro Glu Asp 
    1250                 1255                 1260             


Asn Glu  Gln Lys Gln Leu Phe  Val Glu Gln His Lys  His Tyr Leu 
    1265                 1270                 1275             


Asp Glu  Ile Ile Glu Gln Ile  Ser Glu Phe Ser Lys  Arg Val Ile 
    1280                 1285                 1290             


Leu Ala  Asp Ala Asn Leu Asp  Lys Val Leu Ser Ala  Tyr Asn Lys 
    1295                 1300                 1305             


His Arg  Asp Lys Pro Ile Arg  Glu Gln Ala Glu Asn  Ile Ile His 
    1310                 1315                 1320             


Leu Phe  Thr Leu Thr Asn Leu  Gly Ala Pro Ala Ala  Phe Lys Tyr 
    1325                 1330                 1335             


Phe Asp  Thr Thr Ile Asp Arg  Lys Arg Tyr Thr Ser  Thr Lys Glu 
    1340                 1345                 1350             


Val Leu  Asp Ala Thr Leu Ile  His Gln Ser Ile Thr  Gly Leu Tyr 
    1355                 1360                 1365             


Glu Thr  Arg Ile Asp Leu Ser  Gln Leu Gly Gly Asp  Lys Arg Pro 
    1370                 1375                 1380             


Ala Ala  Thr Lys Lys Ala Gly  Gln Ala Lys Lys Lys  Lys 
    1385                 1390                 1395     


<210>  2
<211>  23
<212>  DNA
<213>  Homo sapiens

<400>  2
tggttgcaca gtaagtggcg ggg                                               23


<210>  3
<211>  23
<212>  DNA
<213>  Homo sapiens

<400>  3
agtgggccac actgcgacaa ggg                                               23


<210>  4
<211>  20
<212>  DNA
<213>  Homo sapiens

<400>  4
tatccgaggc acgttaaggg                                                   20


<210>  5
<211>  20
<212>  DNA
<213>  Homo sapiens

<400>  5
cacgaggttg acgcaccaga                                                   20


<210>  6
<211>  504
<212>  PRT
<213>  Homo sapiens

<400>  6

Met Ala Ser Thr Asp Tyr Ser Thr Tyr Ser Gln Ala Ala Ala Gln Gln 
1               5                   10                  15      


Gly Tyr Ser Ala Tyr Thr Ala Gln Pro Thr Gln Gly Tyr Ala Gln Thr 
            20                  25                  30          


Thr Gln Ala Tyr Gly Gln Gln Ser Tyr Gly Thr Tyr Gly Gln Pro Thr 
        35                  40                  45              


Asp Val Ser Tyr Thr Gln Ala Gln Thr Thr Ala Thr Tyr Gly Gln Thr 
    50                  55                  60                  


Ala Tyr Ala Thr Ser Tyr Gly Gln Pro Pro Thr Val Glu Gly Thr Ser 
65                  70                  75                  80  


Thr Gly Tyr Thr Thr Pro Thr Ala Pro Gln Ala Tyr Ser Gln Pro Val 
                85                  90                  95      


Gln Gly Tyr Gly Thr Gly Ala Tyr Asp Thr Thr Thr Ala Thr Val Thr 
            100                 105                 110         


Thr Thr Gln Ala Ser Tyr Ala Ala Gln Ser Ala Tyr Gly Thr Gln Pro 
        115                 120                 125             


Ala Tyr Pro Ala Tyr Gly Gln Gln Pro Ala Ala Thr Ala Pro Thr Arg 
    130                 135                 140                 


Pro Gln Asp Gly Asn Lys Pro Thr Glu Thr Ser Gln Pro Gln Ser Ser 
145                 150                 155                 160 


Thr Gly Gly Tyr Asn Gln Pro Ser Leu Gly Tyr Gly Gln Ser Asn Tyr 
                165                 170                 175     


Ser Tyr Pro Gln Val Pro Gly Ser Tyr Pro Met Gln Pro Val Thr Ala 
            180                 185                 190         


Pro Pro Ser Tyr Pro Pro Thr Ser Tyr Ser Ser Thr Gln Pro Thr Ser 
        195                 200                 205             


Tyr Asp Gln Ser Ser Tyr Ser Gln Gln Asn Thr Tyr Gly Gln Pro Ser 
    210                 215                 220                 


Ser Tyr Gly Gln Gln Ser Ser Tyr Gly Gln Gln Ser Ser Tyr Gly Gln 
225                 230                 235                 240 


Gln Pro Pro Thr Ser Tyr Pro Pro Gln Thr Gly Ser Tyr Ser Gln Ala 
                245                 250                 255     


Pro Ser Gln Tyr Ser Gln Gln Ser Ser Ser Tyr Gly Gln Gln Asn Pro 
            260                 265                 270         


Ser Tyr Asp Ser Val Arg Arg Gly Ala Trp Gly Asn Asn Met Asn Ser 
        275                 280                 285             


Gly Leu Asn Lys Ser Pro Pro Leu Gly Gly Ala Gln Thr Ile Ser Lys 
    290                 295                 300                 


Asn Thr Glu Gln Arg Pro Gln Pro Asp Pro Tyr Gln Ile Leu Gly Pro 
305                 310                 315                 320 


Thr Ser Ser Arg Leu Ala Asn Pro Gly Ser Gly Gln Ile Gln Leu Trp 
                325                 330                 335     


Gln Phe Leu Leu Glu Leu Leu Ser Asp Ser Ala Asn Ala Ser Cys Ile 
            340                 345                 350         


Thr Trp Glu Gly Thr Asn Gly Glu Phe Lys Met Thr Asp Pro Asp Glu 
        355                 360                 365             


Val Ala Arg Arg Trp Gly Glu Arg Lys Ser Lys Pro Asn Met Asn Tyr 
    370                 375                 380                 


Asp Lys Leu Ser Arg Ala Leu Arg Tyr Tyr Tyr Asp Lys Asn Ile Met 
385                 390                 395                 400 


Thr Lys Val His Gly Lys Arg Tyr Ala Tyr Lys Phe Asp Phe His Gly 
                405                 410                 415     


Ile Ala Gln Ala Leu Gln Pro His Pro Thr Glu Ser Ser Met Tyr Lys 
            420                 425                 430         


Tyr Pro Ser Asp Ile Ser Tyr Met Pro Ser Tyr His Ala His Gln Gln 
        435                 440                 445             


Lys Val Asn Phe Val Pro Pro His Pro Ser Ser Met Pro Val Thr Ser 
    450                 455                 460                 


Ser Ser Phe Phe Gly Ala Ala Ser Gln Tyr Trp Thr Ser Pro Thr Gly 
465                 470                 475                 480 


Gly Ile Tyr Pro Asn Pro Asn Val Pro Arg His Pro Asn Thr His Val 
                485                 490                 495     


Pro Ser His Leu Gly Ser Tyr Tyr 
            500                 


<210>  7
<211>  68
<212>  PRT
<213>  Homo sapiens

<400>  7

Met Ala Ser Thr Asp Tyr Ser Thr Tyr Ser Gln Ala Ala Ala Gln Gln 
1               5                   10                  15      


Gly Tyr Ser Ala Tyr Thr Ala Gln Pro Thr Gln Gly Tyr Ala Gln Thr 
            20                  25                  30          


Thr Gln Glu Ala Gly Arg Ser Ser Cys Gly Asn Ser Ser Trp Ser Cys 
        35                  40                  45              


Ser Pro Thr Ala Pro Thr Pro Ala Val Ser Pro Gly Arg Gly Pro Thr 
    50                  55                  60                  


Gly Ser Ser Lys 
65              


<210>  8
<211>  81
<212>  DNA
<213>  Homo sapiens

<400>  8
gcagtgcata gatattaagt aacttgccag tggttgcaca gtaagtggcg gggttagctc       60

taaaaactgg cgacctagcc a                                                 81


<210>  9
<211>  81
<212>  DNA
<213>  Homo sapiens

<400>  9
gcagtgcata gatattaagt aacttgccag tggttgcaca gtaagtgcgg ggttagctct       60

aaaaactggc gacctagcca a                                                 81


<210>  10
<211>  84
<212>  DNA
<213>  Homo sapiens

<400>  10
gcagtgcata gatattaagt aacttgccag tggttgcaca gtaagtgtgg cggggttagc       60

tctaaaaact ggcgacctag ccaa                                              84


<210>  11
<211>  83
<212>  DNA
<213>  Homo sapiens

<400>  11
gcagtgcata gatattaagt aacttgccag tggttgcaca gtaagtgggc ggggttagct       60

ctaaaaactg gcgacctagc caa                                               83


<210>  12
<211>  79
<212>  DNA
<213>  Homo sapiens

<400>  12
gcagtgcata gatattaagt aacttgccag tggttgcaca gtaagcgggg ttagctctaa       60

aaactggcga cctagccaa                                                    79


<210>  13
<211>  70
<212>  DNA
<213>  Homo sapiens

<400>  13
gcagtgcata gatattaagt aacttgccag tggttgcggg gttagctcta aaaactggcg       60

acctagccaa                                                              70


<210>  14
<211>  80
<212>  DNA
<213>  Homo sapiens

<400>  14
gcagtgcata gatattaagt aacttgccag tggttgcaca gtaaggcggg gttagctcta       60

aaaactggcg acctagccaa                                                   80


<210>  15
<211>  67
<212>  DNA
<213>  Homo sapiens

<400>  15
gcagtgcata gatattaagt aacttgccag tggcggggtt agctctaaaa actggcgacc       60

tagccaa                                                                 67


<210>  16
<211>  75
<212>  DNA
<213>  Homo sapiens

<400>  16
gcagtgcata gatattaagt aacttgccag tggttgcaca gcggggttag ctctaaaaac       60

tggcgaccta gccaa                                                        75


<210>  17
<211>  70
<212>  DNA
<213>  Homo sapiens

<400>  17
gcagtgcata gatattaagt aacttgccag tggttgcaca gttagctcta aaaactggcg       60

acctagccaa                                                              70


<210>  18
<211>  62
<212>  DNA
<213>  Homo sapiens

<400>  18
gcagtgcata gatattaagt aacttgccag tggttagctc taaaaactgg cgacctagcc       60

aa                                                                      62


<210>  19
<211>  78
<212>  DNA
<213>  Homo sapiens

<400>  19
gcagtgcata gatattaagt aacttgccag tggttgcaca gtagcggggt tagctctaaa       60

aactggcgac ctagccaa                                                     78


<210>  20
<211>  83
<212>  DNA
<213>  Homo sapiens

<400>  20
tgggtaggca gagtccctgg gatgggaagg tgagtgggcc acactgcgac aagggcctgc       60

tagctcccaa tctcgatgga ctt                                               83


<210>  21
<211>  84
<212>  DNA
<213>  Homo sapiens

<400>  21
tgggtaggca gagtccctgg gatgggaagg tgagtgggcc acactgcgaa caagggcctg       60

ctagctccca atctcgatgg actt                                              84


<210>  22
<211>  70
<212>  DNA
<213>  Homo sapiens

<400>  22
tgggtaggca gagtccctgg gatgggaagg tgagtgggcc acactgctag ctcccaatct       60

cgatggactt                                                              70


<210>  23
<211>  66
<212>  DNA
<213>  Homo sapiens

<400>  23
tgggtaggca gagtccctgg gatgggaagg tgagtgggcc tgctagctcc caatctcgat       60

ggactt                                                                  66


<210>  24
<211>  82
<212>  DNA
<213>  Homo sapiens

<400>  24
tgggtaggca gagtccctgg gatgggaagg tgagtgggcc acactgcgaa agggcctgct       60

agctcccaat ctcgatggac tt                                                82


<210>  25
<211>  80
<212>  DNA
<213>  Homo sapiens

<400>  25
tgggtaggca gagtccctgg gatgggaagg tgagtgggcc acactgcgag ggcctgctag       60

ctcccaatct cgatggactt                                                   80


<210>  26
<211>  80
<212>  DNA
<213>  Homo sapiens

<400>  26
tgggtaggca gagtccctgg gatgggaagg tgagtgggcc acactgcaag ggcctgctag       60

ctcccaatct cgatggactt                                                   80


<210>  27
<211>  81
<212>  DNA
<213>  Homo sapiens

<400>  27
tgggtaggca gagtccctgg gatgggaagg tgagtgggcc acactgcgaa gggcctgcta       60

gctcccaatc tcgatggact t                                                 81


<210>  28
<211>  74
<212>  DNA
<213>  Homo sapiens

<400>  28
tgggtaggca gagtccctgg gatgggaagg tgagtgggcc acactgcgag ctagctccca       60

atctcgatgg actt                                                         74


<210>  29
<211>  65
<212>  DNA
<213>  Homo sapiens

<400>  29
tgggtaggca gagtccctgg gatgggaagg tgagtgggcc acactgctcc caatctcgat       60

ggact                                                                   65


<210>  30
<211>  82
<212>  DNA
<213>  Homo sapiens

<400>  30
tgggtaggca gagtccctgg gatgggaagg tgagtgggcc acactgcgca agggcctgct       60

agctcccaat ctcgatggac tt                                                82


<210>  31
<211>  75
<212>  DNA
<213>  Homo sapiens

<400>  31
tgggtaggca gagtccctgg gatgggaagg tgagtgggcc acaagggcct gctagctccc       60

aatctcgatg gactt                                                        75


<210>  32
<211>  5194
<212>  DNA
<213>  Streptococcus pyogenes

<400>  32
gagggcctat ttcccatgat tccttcatat ttgcatatac gatacaaggc tgttagagag       60

ataattagaa ttaatttgac tgtaaacaca aagatattag tacaaaatac gtgacgtaga      120

aagtaataat ttcttgggta gtttgcagtt ttaaaattat gttttaaaat ggactatcat      180

atgcttaccg taacttgaaa gtatttcgat ttcttggctt tatatatctt gtggaaagga      240

cgaaacaccg ggttgcacag taagtggcgg tttaagagct atgctggaaa cagcatagca      300

agtttaaata aggctagtcc gttatcaact tgaaaaagtg gcaccgagtc ggtgcttttt      360

gctagccgaa cgctgacgtc atcaacccgc tccaaggaat cgcgggccca gtgtcactag      420

gcgggaacac ccagcgcgcg tgcgccctgg caggaagatg gctgtgaggg acaggggagt      480

ggcgccctgc aatatttgca tgtcgctatg tgttctggga aatcaccata aacgtgaaat      540

gtctttggat ttgggaatct tataagttct gtatgagacc actctttccc ggtgggccac      600

actgcgacaa gtttaagagc tatgctggaa acagcatagc aagtttaaat aaggctagtc      660

cgttatcaac ttgaaaaagt ggcaccgagt cggtgctttt tctcgagtgg ctccggtgcc      720

cgtcagtggg cagagcgcac atcgcccaca gtccccgaga agttgggggg aggggtcggc      780

aattgaaccg gtgcctagag aaggtggcgc ggggtaaact gggaaagtga tgtcgtgtac      840

tggctccgcc tttttcccga gggtggggga gaaccgtata taagtgcagt agtcgccgtg      900

aacgttcttt ttcgcaacgg gtttgccgcc agaacacagg tgtcgtgacg cgggatccgc      960

caccatggat tacaaagacg atgacgataa gatggcccca aagaagaagc ggaaggtcgg     1020

tatccacgga gtcccagcag ccgacaagaa gtacagcatc ggcctggaca tcggcaccaa     1080

ctctgtgggc tgggccgtga tcaccgacga gtacaaggtg cccagcaaga aattcaaggt     1140

gctgggcaac accgaccggc acagcatcaa gaagaacctg atcggagccc tgctgttcga     1200

cagcggcgaa acagccgagg ccacccggct gaagagaacc gccagaagaa gatacaccag     1260

acggaagaac cggatctgct atctgcaaga gatcttcagc aacgagatgg ccaaggtgga     1320

cgacagcttc ttccacagac tggaagagtc cttcctggtg gaagaggata agaagcacga     1380

gcggcacccc atcttcggca acatcgtgga cgaggtggcc taccacgaga agtaccccac     1440

catctaccac ctgagaaaga aactggtgga cagcaccgac aaggccgacc tgcggctgat     1500

ctatctggcc ctggcccaca tgatcaagtt ccggggccac ttcctgatcg agggcgacct     1560

gaaccccgac aacagcgacg tggacaagct gttcatccag ctggtgcaga cctacaacca     1620

gctgttcgag gaaaacccca tcaacgccag cggcgtggac gccaaggcca tcctgtctgc     1680

cagactgagc aagagcagac ggctggaaaa tctgatcgcc cagctgcccg gcgagaagaa     1740

gaatggcctg ttcggaaacc tgattgccct gagcctgggc ctgaccccca acttcaagag     1800

caacttcgac ctggccgagg atgccaaact gcagctgagc aaggacacct acgacgacga     1860

cctggacaac ctgctggccc agatcggcga ccagtacgcc gacctgtttc tggccgccaa     1920

gaacctgtcc gacgccatcc tgctgagcga catcctgaga gtgaacaccg agatcaccaa     1980

ggcccccctg agcgcctcta tgatcaagag atacgacgag caccaccagg acctgaccct     2040

gctgaaagct ctcgtgcggc agcagctgcc tgagaagtac aaagagattt tcttcgacca     2100

gagcaagaac ggctacgccg gctacattga cggcggagcc agccaggaag agttctacaa     2160

gttcatcaag cccatcctgg aaaagatgga cggcaccgag gaactgctcg tgaagctgaa     2220

cagagaggac ctgctgcgga agcagcggac cttcgacaac ggcagcatcc cccaccagat     2280

ccacctggga gagctgcacg ccattctgcg gcggcaggaa gatttttacc cattcctgaa     2340

ggacaaccgg gaaaagatcg agaagatcct gaccttccgc atcccctact acgtgggccc     2400

tctggccagg ggaaacagca gattcgcctg gatgaccaga aagagcgagg aaaccatcac     2460

cccctggaac ttcgaggaag tggtggacaa gggcgcttcc gcccagagct tcatcgagcg     2520

gatgaccaac ttcgataaga acctgcccaa cgagaaggtg ctgcccaagc acagcctgct     2580

gtacgagtac ttcaccgtgt ataacgagct gaccaaagtg aaatacgtga ccgagggaat     2640

gagaaagccc gccttcctga gcggcgagca gaaaaaggcc atcgtggacc tgctgttcaa     2700

gaccaaccgg aaagtgaccg tgaagcagct gaaagaggac tacttcaaga aaatcgagtg     2760

cttcgactcc gtggaaatct ccggcgtgga agatcggttc aacgcctccc tgggcacata     2820

ccacgatctg ctgaaaatta tcaaggacaa ggacttcctg gacaatgagg aaaacgagga     2880

cattctggaa gatatcgtgc tgaccctgac actgtttgag gacagagaga tgatcgagga     2940

acggctgaaa acctatgccc acctgttcga cgacaaagtg atgaagcagc tgaagcggcg     3000

gagatacacc ggctggggca ggctgagccg gaagctgatc aacggcatcc gggacaagca     3060

gtccggcaag acaatcctgg atttcctgaa gtccgacggc ttcgccaaca gaaacttcat     3120

gcagctgatc cacgacgaca gcctgacctt taaagaggac atccagaaag cccaggtgtc     3180

cggccagggc gatagcctgc acgagcacat tgccaatctg gccggcagcc ccgccattaa     3240

gaagggcatc ctgcagacag tgaaggtggt ggacgagctc gtgaaagtga tgggccggca     3300

caagcccgag aacatcgtga tcgaaatggc cagagagaac cagaccaccc agaagggaca     3360

gaagaacagc cgcgagagaa tgaagcggat cgaagagggc atcaaagagc tgggcagcca     3420

gatcctgaaa gaacaccccg tggaaaacac ccagctgcag aacgagaagc tgtacctgta     3480

ctacctgcag aatgggcggg atatgtacgt ggaccaggaa ctggacatca accggctgtc     3540

cgactacgat gtggaccata tcgtgcctca gagctttctg aaggacgact ccatcgacaa     3600

caaggtgctg accagaagcg acaagaaccg gggcaagagc gacaacgtgc cctccgaaga     3660

ggtcgtgaag aagatgaaga actactggcg gcagctgctg aacgccaagc tgattaccca     3720

gagaaagttc gacaatctga ccaaggccga gagaggcggc ctgagcgaac tggataaggc     3780

cggcttcatc aagagacagc tggtggaaac ccggcagatc acaaagcacg tggcacagat     3840

cctggactcc cggatgaaca ctaagtacga cgagaatgac aagctgatcc gggaagtgaa     3900

agtgatcacc ctgaagtcca agctggtgtc cgatttccgg aaggatttcc agttttacaa     3960

agtgcgcgag atcaacaact accaccacgc ccacgacgcc tacctgaacg ccgtcgtggg     4020

aaccgccctg atcaaaaagt accctaagct ggaaagcgag ttcgtgtacg gcgactacaa     4080

ggtgtacgac gtgcggaaga tgatcgccaa gagcgagcag gaaatcggca aggctaccgc     4140

caagtacttc ttctacagca acatcatgaa ctttttcaag accgagatta ccctggccaa     4200

cggcgagatc cggaagcggc ctctgatcga gacaaacggc gaaaccgggg agatcgtgtg     4260

ggataagggc cgggattttg ccaccgtgcg gaaagtgctg agcatgcccc aagtgaatat     4320

cgtgaaaaag accgaggtgc agacaggcgg cttcagcaaa gagtctatcc tgcccaagag     4380

gaacagcgat aagctgatcg ccagaaagaa ggactgggac cctaagaagt acggcggctt     4440

cgacagcccc accgtggcct attctgtgct ggtggtggcc aaagtggaaa agggcaagtc     4500

caagaaactg aagagtgtga aagagctgct ggggatcacc atcatggaaa gaagcagctt     4560

cgagaagaat cccatcgact ttctggaagc caagggctac aaagaagtga aaaaggacct     4620

gatcatcaag ctgcctaagt actccctgtt cgagctggaa aacggccgga agagaatgct     4680

ggcctctgcc ggcgaactgc agaagggaaa cgaactggcc ctgccctcca aatatgtgaa     4740

cttcctgtac ctggccagcc actatgagaa gctgaagggc tcccccgagg ataatgagca     4800

gaaacagctg tttgtggaac agcacaagca ctacctggac gagatcatcg agcagatcag     4860

cgagttctcc aagagagtga tcctggccga cgctaatctg gacaaagtgc tgtccgccta     4920

caacaagcac cgggataagc ccatcagaga gcaggccgag aatatcatcc acctgtttac     4980

cctgaccaat ctgggagccc ctgccgcctt caagtacttt gacaccacca tcgaccggaa     5040

gaggtacacc agcaccaaag aggtgctgga cgccaccctg atccaccaga gcatcaccgg     5100

cctgtacgag acacggatcg acctgtctca gctgggaggc gacaagcgtc ctgctgctac     5160

taagaaagct ggtcaagcta agaaaaagaa atag                                 5194


<210>  33
<211>  23
<212>  DNA
<213>  Homo sapiens

<400>  33
taagaggaca tacagcgttc tgg                                               23


<210>  34
<211>  23
<212>  DNA
<213>  Homo sapiens

<400>  34
atttggacct gtggcgatat ggg                                               23


<210>  35
<211>  23
<212>  DNA
<213>  Homo sapiens

<400>  35
cgggcggatc atataaggtc agg                                               23


<210>  36
<211>  23
<212>  DNA
<213>  Homo sapiens

<400>  36
caagtcgatc ccaatgtcga agg                                               23


<210>  37
<211>  23
<212>  DNA
<213>  Homo sapiens

<400>  37
tagatcgcgt actccatcct ggg                                               23


<210>  38
<211>  20
<212>  DNA
<213>  Homo sapiens

<400>  38
gacatgacca tgggtaagcg                                                   20


<210>  39
<211>  20
<212>  DNA
<213>  Homo sapiens

<400>  39
tccctaatag tgatggcgct                                                   20


<210>  40
<211>  20
<212>  DNA
<213>  Homo sapiens

<400>  40
gcccagccca ctcaaggata                                                   20


<210>  41
<211>  20
<212>  DNA
<213>  Homo sapiens

<400>  41
ttggggttgg ggtagattcc                                                   20


<210>  42
<211>  19
<212>  DNA
<213>  Homo sapiens

<400>  42
gcagggctac agtgcttac                                                    19


<210>  43
<211>  19
<212>  DNA
<213>  Homo sapiens

<400>  43
gcagctccag gaggaattg                                                    19


<210>  44
<211>  19
<212>  DNA
<213>  Homo sapiens

<400>  44
aggtgccctg ttccatgct                                                    19


<210>  45
<211>  19
<212>  DNA
<213>  Homo sapiens

<400>  45
aggtgccctg ttccatgct                                                    19


<210>  46
<211>  20
<212>  DNA
<213>  Homo sapiens

<400>  46
gtgagtttac cttggcctgc                                                   20


<210>  47
<211>  20
<212>  DNA
<213>  Homo sapiens

<400>  47
gtgagtttac cttggcctgc                                                   20


<210>  48
<211>  20
<212>  DNA
<213>  Homo sapiens

<400>  48
cccagccaga tccgtatcag                                                   20


<210>  49
<211>  19
<212>  DNA
<213>  Homo sapiens

<400>  49
gcagctccag gaggaattg                                                    19


<210>  50
<211>  19
<212>  DNA
<213>  Homo sapiens

<400>  50
gcagggctac agtgcttac                                                    19


<210>  51
<211>  23
<212>  DNA
<213>  Homo sapiens

<400>  51
aagacgtctt gctcccctcg ggg                                               23


<210>  52
<211>  19
<212>  DNA
<213>  Homo sapiens

<400>  52
accacagtcc atgccatca                                                    19


<210>  53
<211>  20
<212>  DNA
<213>  Homo sapiens

<400>  53
tccaccaccc tgttgctgta                                                   20


<210>  54
<211>  20
<212>  DNA
<213>  Homo sapiens

<400>  54
gatgccaagg atccaacgac                                                   20


<210>  55
<211>  20
<212>  DNA
<213>  Homo sapiens

<400>  55
ggcttcacac cattccccat                                                   20


<210>  56
<211>  22
<212>  DNA
<213>  Homo sapiens

<400>  56
gctgtcatct cttgtgggct gt                                                22


<210>  57
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  57
actcatggga gctgctggtt c                                                 21


<210>  58
<211>  19
<212>  DNA
<213>  Homo sapiens

<400>  58
accacagtcc atgccatca                                                    19


<210>  59
<211>  20
<212>  DNA
<213>  Homo sapiens

<400>  59
tccaccaccc tgttgctgta                                                   20


<210>  60
<211>  47
<212>  DNA
<213>  Homo sapiens

<400>  60
ctttccctac acgacgctct tccgatctag gtgccctgtt ccatgct                     47


<210>  61
<211>  53
<212>  DNA
<213>  Homo sapiens

<400>  61
gactggagtt cagacgtgtg ctcttccgat cttggcctag gcttttcaac aga              53


<210>  62
<211>  48
<212>  DNA
<213>  Homo sapiens

<400>  62
ctttccctac acgacgctct tccgatctat ggtattctca cgctgcca                    48


<210>  63
<211>  53
<212>  DNA
<213>  Homo sapiens

<400>  63
gactggagtt cagacgtgtg ctcttccgat cttggagatg aatgggaagc gaa              53


<210>  64
<211>  51
<212>  DNA
<213>  Homo sapiens

<400>  64
ctttccctac acgacgctct tccgatcttc ccacttgttt attcctctgt g                51


<210>  65
<211>  54
<212>  DNA
<213>  Homo sapiens

<400>  65
gactggagtt cagacgtgtg ctcttccgat ctattccaga gaaggacatt gcca             54


<210>  66
<211>  48
<212>  DNA
<213>  Homo sapiens

<400>  66
ctttccctac acgacgctct tccgatcttg ggagttctct aaggctgc                    48


<210>  67
<211>  52
<212>  DNA
<213>  Homo sapiens

<400>  67
gactggagtt cagacgtgtg ctcttccgat ctgtgacttt tcccaccgcc tc               52


<210>  68
<211>  50
<212>  DNA
<213>  Homo sapiens

<400>  68
ctttccctac acgacgctct tccgatctct ccttttctcc tcctgccagc                  50


<210>  69
<211>  52
<212>  DNA
<213>  Homo sapiens

<400>  69
gactggagtt cagacgtgtg ctcttccgat ctgacttgga tcttcaaccg cc               52


<210>  70
<211>  52
<212>  DNA
<213>  Homo sapiens

<400>  70
ctttccctac acgacgctct tccgatctag cttgctattc tttgagatga ac               52


<210>  71
<211>  53
<212>  DNA
<213>  Homo sapiens

<400>  71
gactggagtt cagacgtgtg ctcttccgat cttgaataaa ggccccgatg acc              53


<210>  72
<211>  48
<212>  DNA
<213>  Homo sapiens

<400>  72
ctttccctac acgacgctct tccgatctcc tgggttgtaa ctgtgggt                    48


<210>  73
<211>  54
<212>  DNA
<213>  Homo sapiens

<400>  73
gactggagtt cagacgtgtg ctcttccgat ctttctggga gtcgtaggct tagt             54


<210>  74
<211>  48
<212>  DNA
<213>  Homo sapiens

<400>  74
ctttccctac acgacgctct tccgatctct cgggcctgtt ccttcata                    48


<210>  75
<211>  52
<212>  DNA
<213>  Homo sapiens

<400>  75
gactggagtt cagacgtgtg ctcttccgat ctccacctcc agaagccctt ag               52


<210>  76
<211>  49
<212>  DNA
<213>  Homo sapiens

<400>  76
ctttccctac acgacgctct tccgatctgc aagaatttca aggccccag                   49


<210>  77
<211>  52
<212>  DNA
<213>  Homo sapiens

<400>  77
gactggagtt cagacgtgtg ctcttccgat ctagggatga cttgactgct ga               52


<210>  78
<211>  48
<212>  DNA
<213>  Homo sapiens

<400>  78
ctttccctac acgacgctct tccgatctgt cactcacctg gctgcttc                    48


<210>  79
<211>  55
<212>  DNA
<213>  Homo sapiens

<400>  79
gactggagtt cagacgtgtg ctcttccgat ctagcattcc tcatttgatt ccaga            55


<210>  80
<211>  47
<212>  DNA
<213>  Homo sapiens

<400>  80
ctttccctac acgacgctct tccgatctgt tgtctcccgc atgccag                     47


<210>  81
<211>  51
<212>  DNA
<213>  Homo sapiens

<400>  81
gactggagtt cagacgtgtg ctcttccgat ctggaatggg taggcagagt c                51


<210>  82
<211>  50
<212>  DNA
<213>  Homo sapiens

<400>  82
ctttccctac acgacgctct tccgatctag ggagggtcta atctaggagc                  50


<210>  83
<211>  53
<212>  DNA
<213>  Homo sapiens

<400>  83
gactggagtt cagacgtgtg ctcttccgat ctccctcttc cccaccattt tgt              53


<210>  84
<211>  49
<212>  DNA
<213>  Homo sapiens

<400>  84
ctttccctac acgacgctct tccgatctgc atacagggct tctttcgtg                   49


<210>  85
<211>  52
<212>  DNA
<213>  Homo sapiens

<400>  85
gactggagtt cagacgtgtg ctcttccgat ctcgttcttc ctgtgccatc ct               52


<210>  86
<211>  48
<212>  DNA
<213>  Homo sapiens

<400>  86
ctttccctac acgacgctct tccgatcttg tgtggaggag ggagtcaa                    48


<210>  87
<211>  53
<212>  DNA
<213>  Homo sapiens

<400>  87
gactggagtt cagacgtgtg ctcttccgat ctggccttca gaactcatca agg              53


<210>  88
<211>  48
<212>  DNA
<213>  Homo sapiens

<400>  88
ctttccctac acgacgctct tccgatctat cctcacagag cattgcag                    48


<210>  89
<211>  53
<212>  DNA
<213>  Homo sapiens

<400>  89
gactggagtt cagacgtgtg ctcttccgat ctgtactgat tctggggctt gct              53


<210>  90
<211>  49
<212>  DNA
<213>  Homo sapiens

<400>  90
ctttccctac acgacgctct tccgatctcg ttggctgtgt gtctgtttc                   49


<210>  91
<211>  52
<212>  DNA
<213>  Homo sapiens

<400>  91
gactggagtt cagacgtgtg ctcttccgat ctaggagtgg ggagtctttc gt               52


<210>  92
<211>  48
<212>  DNA
<213>  Homo sapiens

<400>  92
ctttccctac acgacgctct tccgatctag gagaccgatg gacagacg                    48


<210>  93
<211>  52
<212>  DNA
<213>  Homo sapiens

<400>  93
gactggagtt cagacgtgtg ctcttccgat ctcctccctc ctttcccctg ac               52


<210>  94
<211>  50
<212>  DNA
<213>  Homo sapiens

<400>  94
ctttccctac acgacgctct tccgatcttc cataagttga ctctggcagg                  50


<210>  95
<211>  52
<212>  DNA
<213>  Homo sapiens

<400>  95
gactggagtt cagacgtgtg ctcttccgat ctagagtgcc ttggtcaaat gg               52


<210>  96
<211>  49
<212>  DNA
<213>  Homo sapiens

<400>  96
ctttccctac acgacgctct tccgatctag tgttgggatt acaggcgtg                   49


<210>  97
<211>  53
<212>  DNA
<213>  Homo sapiens

<400>  97
gactggagtt cagacgtgtg ctcttccgat ctgcctggga atttcactgt gcc              53


<210>  98
<211>  47
<212>  DNA
<213>  Homo sapiens

<400>  98
ctttccctac acgacgctct tccgatctag ttcccctctc ctccctg                     47


<210>  99
<211>  52
<212>  DNA
<213>  Homo sapiens

<400>  99
gactggagtt cagacgtgtg ctcttccgat ctcacttccc atggacagct tg               52


<210>  100
<211>  49
<212>  DNA
<213>  Homo sapiens

<400>  100
ctttccctac acgacgctct tccgatctga ggggtaaagg attggagcc                   49


<210>  101
<211>  52
<212>  DNA
<213>  Homo sapiens

<400>  101
gactggagtt cagacgtgtg ctcttccgat ctcggagaga ttgaagggag cg               52


<210>  102
<211>  28
<212>  DNA
<213>  Homo sapiens

<400>  102
gtcataagaa gggttctgct gcccgtag                                          28


<210>  103
<211>  28
<212>  DNA
<213>  Homo sapiens

<400>  103
ggccagcagt gaactctgct gcccgtag                                          28


<210>  104
<211>  28
<212>  DNA
<213>  Homo sapiens

<400>  104
ccgctgaagg gcttttgaac tctgctta                                          28


<210>  105
<211>  20
<212>  DNA
<213>  Homo sapiens

<400>  105
tggttgcaca gtaagtggcg                                                   20


<210>  106
<211>  20
<212>  DNA
<213>  Homo sapiens

<400>  106
tgattgcact gtaagtggcc                                                   20


<210>  107
<211>  20
<212>  DNA
<213>  Homo sapiens

<400>  107
taggtgctca gtaagtggct                                                   20


<210>  108
<211>  20
<212>  DNA
<213>  Homo sapiens

<400>  108
cgacttcaca gtaagtggcg                                                   20


<210>  109
<211>  20
<212>  DNA
<213>  Homo sapiens

<400>  109
aggtagcgca gttagtggcg                                                   20


<210>  110
<211>  20
<212>  DNA
<213>  Homo sapiens

<400>  110
aggtagaaca gtaagtggca                                                   20


<210>  111
<211>  20
<212>  DNA
<213>  Homo sapiens

<400>  111
tagttgttca gtaagtggca                                                   20


<210>  112
<211>  20
<212>  DNA
<213>  Homo sapiens

<400>  112
gggtagcaga ggaagtggcg                                                   20


<210>  113
<211>  20
<212>  DNA
<213>  Homo sapiens

<400>  113
tggatgctga gtaagtggcc                                                   20


<210>  114
<211>  20
<212>  DNA
<213>  Homo sapiens

<400>  114
tgcttgcaag gtaagtggcc                                                   20


<210>  115
<211>  20
<212>  DNA
<213>  Homo sapiens

<400>  115
agtgggccac actgcgacaa                                                   20


<210>  116
<211>  20
<212>  DNA
<213>  Homo sapiens

<400>  116
gattggccac actgtgacaa                                                   20


<210>  117
<211>  20
<212>  DNA
<213>  Homo sapiens

<400>  117
ggcggggcac acagcgacaa                                                   20


<210>  118
<211>  20
<212>  DNA
<213>  Homo sapiens

<400>  118
agtgaggaac actgcggcaa                                                   20


<210>  119
<211>  20
<212>  DNA
<213>  Homo sapiens

<400>  119
tgtgggccag gctgcggcaa                                                   20


<210>  120
<211>  20
<212>  DNA
<213>  Homo sapiens

<400>  120
agtgggctag cctgcgacag                                                   20


<210>  121
<211>  20
<212>  DNA
<213>  Homo sapiens

<400>  121
agtggggctg tctgcgacaa                                                   20


<210>  122
<211>  20
<212>  DNA
<213>  Homo sapiens

<400>  122
tgtgaaccac actgtgacaa                                                   20


<210>  123
<211>  20
<212>  DNA
<213>  Homo sapiens

<400>  123
agtgtgctcc actgtgacaa                                                   20


<210>  124
<211>  20
<212>  DNA
<213>  Homo sapiens

<400>  124
cgtgggccag cctgggacaa                                                   20


<210>  125
<211>  20
<212>  DNA
<213>  Homo sapiens

<400>  125
agagagccac actgagacag                                                   20


<210>  126
<211>  1094
<212>  PRT
<213>  Prevotella buccalis

<400>  126

Met Asn Ile Pro Ala Leu Val Glu Asn Gln Lys Lys Tyr Phe Gly Thr 
1               5                   10                  15      


Tyr Ser Val Met Ala Met Leu Asn Ala Gln Thr Val Leu Asp His Ile 
            20                  25                  30          


Gln Lys Val Ala Asp Ile Glu Gly Glu Gln Asn Glu Asn Asn Glu Asn 
        35                  40                  45              


Leu Trp Phe His Pro Val Met Ser His Leu Tyr Asn Ala Lys Asn Gly 
    50                  55                  60                  


Tyr Asp Lys Gln Pro Glu Lys Thr Met Phe Ile Ile Glu Arg Leu Gln 
65                  70                  75                  80  


Ser Tyr Phe Pro Phe Leu Lys Ile Met Ala Glu Asn Gln Arg Glu Tyr 
                85                  90                  95      


Ser Asn Gly Lys Tyr Lys Gln Asn Arg Val Glu Val Asn Ser Asn Asp 
            100                 105                 110         


Ile Phe Glu Val Leu Lys Arg Ala Phe Gly Val Leu Lys Met Tyr Arg 
        115                 120                 125             


Asp Leu Thr Asn His Tyr Lys Thr Tyr Glu Glu Lys Leu Asn Asp Gly 
    130                 135                 140                 


Cys Glu Phe Leu Thr Ser Thr Glu Gln Pro Leu Ser Gly Met Ile Asn 
145                 150                 155                 160 


Asn Tyr Tyr Thr Val Ala Leu Arg Asn Met Asn Glu Arg Tyr Gly Tyr 
                165                 170                 175     


Lys Thr Glu Asp Leu Ala Phe Ile Gln Asp Lys Arg Phe Lys Phe Val 
            180                 185                 190         


Lys Asp Ala Tyr Gly Lys Lys Lys Ser Gln Val Asn Thr Gly Phe Phe 
        195                 200                 205             


Leu Ser Leu Gln Asp Tyr Asn Gly Asp Thr Gln Lys Lys Leu His Leu 
    210                 215                 220                 


Ser Gly Val Gly Ile Ala Leu Leu Ile Cys Leu Phe Leu Asp Lys Gln 
225                 230                 235                 240 


Tyr Ile Asn Ile Phe Leu Ser Arg Leu Pro Ile Phe Ser Ser Tyr Asn 
                245                 250                 255     


Ala Gln Ser Glu Glu Arg Arg Ile Ile Ile Arg Ser Phe Gly Ile Asn 
            260                 265                 270         


Ser Ile Lys Leu Pro Lys Asp Arg Ile His Ser Glu Lys Ser Asn Lys 
        275                 280                 285             


Ser Val Ala Met Asp Met Leu Asn Glu Val Lys Arg Cys Pro Asp Glu 
    290                 295                 300                 


Leu Phe Thr Thr Leu Ser Ala Glu Lys Gln Ser Arg Phe Arg Ile Ile 
305                 310                 315                 320 


Ser Asp Asp His Asn Glu Val Leu Met Lys Arg Ser Ser Asp Arg Phe 
                325                 330                 335     


Val Pro Leu Leu Leu Gln Tyr Ile Asp Tyr Gly Lys Leu Phe Asp His 
            340                 345                 350         


Ile Arg Phe His Val Asn Met Gly Lys Leu Arg Tyr Leu Leu Lys Ala 
        355                 360                 365             


Asp Lys Thr Cys Ile Asp Gly Gln Thr Arg Val Arg Val Ile Glu Gln 
    370                 375                 380                 


Pro Leu Asn Gly Phe Gly Arg Leu Glu Glu Ala Glu Thr Met Arg Lys 
385                 390                 395                 400 


Gln Glu Asn Gly Thr Phe Gly Asn Ser Gly Ile Arg Ile Arg Asp Phe 
                405                 410                 415     


Glu Asn Met Lys Arg Asp Asp Ala Asn Pro Ala Asn Tyr Pro Tyr Ile 
            420                 425                 430         


Val Asp Thr Tyr Thr His Tyr Ile Leu Glu Asn Asn Lys Val Glu Met 
        435                 440                 445             


Phe Ile Asn Asp Lys Glu Asp Ser Ala Pro Leu Leu Pro Val Ile Glu 
    450                 455                 460                 


Asp Asp Arg Tyr Val Val Lys Thr Ile Pro Ser Cys Arg Met Ser Thr 
465                 470                 475                 480 


Leu Glu Ile Pro Ala Met Ala Phe His Met Phe Leu Phe Gly Ser Lys 
                485                 490                 495     


Lys Thr Glu Lys Leu Ile Val Asp Val His Asn Arg Tyr Lys Arg Leu 
            500                 505                 510         


Phe Gln Ala Met Gln Lys Glu Glu Val Thr Ala Glu Asn Ile Ala Ser 
        515                 520                 525             


Phe Gly Ile Ala Glu Ser Asp Leu Pro Gln Lys Ile Leu Asp Leu Ile 
    530                 535                 540                 


Ser Gly Asn Ala His Gly Lys Asp Val Asp Ala Phe Ile Arg Leu Thr 
545                 550                 555                 560 


Val Asp Asp Met Leu Thr Asp Thr Glu Arg Arg Ile Lys Arg Phe Lys 
                565                 570                 575     


Asp Asp Arg Lys Ser Ile Arg Ser Ala Asp Asn Lys Met Gly Lys Arg 
            580                 585                 590         


Gly Phe Lys Gln Ile Ser Thr Gly Lys Leu Ala Asp Phe Leu Ala Lys 
        595                 600                 605             


Asp Ile Val Leu Phe Gln Pro Ser Val Asn Asp Gly Glu Asn Lys Ile 
    610                 615                 620                 


Thr Gly Leu Asn Tyr Arg Ile Met Gln Ser Ala Ile Ala Val Tyr Asp 
625                 630                 635                 640 


Ser Gly Asp Asp Tyr Glu Ala Lys Gln Gln Phe Lys Leu Met Phe Glu 
                645                 650                 655     


Lys Ala Arg Leu Ile Gly Lys Gly Thr Thr Glu Pro His Pro Phe Leu 
            660                 665                 670         


Tyr Lys Val Phe Ala Arg Ser Ile Pro Ala Asn Ala Val Glu Phe Tyr 
        675                 680                 685             


Glu Arg Tyr Leu Ile Glu Arg Lys Phe Tyr Leu Thr Gly Leu Ser Asn 
    690                 695                 700                 


Glu Ile Lys Lys Gly Asn Arg Val Asp Val Pro Phe Ile Arg Arg Asp 
705                 710                 715                 720 


Gln Asn Lys Trp Lys Thr Pro Ala Met Lys Thr Leu Gly Arg Ile Tyr 
                725                 730                 735     


Ser Glu Asp Leu Pro Val Glu Leu Pro Arg Gln Met Phe Asp Asn Glu 
            740                 745                 750         


Ile Lys Ser His Leu Lys Ser Leu Pro Gln Met Glu Gly Ile Asp Phe 
        755                 760                 765             


Asn Asn Ala Asn Val Thr Tyr Leu Ile Ala Glu Tyr Met Lys Arg Val 
    770                 775                 780                 


Leu Asp Asp Asp Phe Gln Thr Phe Tyr Gln Trp Asn Arg Asn Tyr Arg 
785                 790                 795                 800 


Tyr Met Asp Met Leu Lys Gly Glu Tyr Asp Arg Lys Gly Ser Leu Gln 
                805                 810                 815     


His Cys Phe Thr Ser Val Glu Glu Arg Glu Gly Leu Trp Lys Glu Arg 
            820                 825                 830         


Ala Ser Arg Thr Glu Arg Tyr Arg Lys Gln Ala Ser Asn Lys Ile Arg 
        835                 840                 845             


Ser Asn Arg Gln Met Arg Asn Ala Ser Ser Glu Glu Ile Glu Thr Ile 
    850                 855                 860                 


Leu Asp Lys Arg Leu Ser Asn Ser Arg Asn Glu Tyr Gln Lys Ser Glu 
865                 870                 875                 880 


Lys Val Ile Arg Arg Tyr Arg Val Gln Asp Ala Leu Leu Phe Leu Leu 
                885                 890                 895     


Ala Lys Lys Thr Leu Thr Glu Leu Ala Asp Phe Asp Gly Glu Arg Phe 
            900                 905                 910         


Lys Leu Lys Glu Ile Met Pro Asp Ala Glu Lys Gly Ile Leu Ser Glu 
        915                 920                 925             


Ile Met Pro Met Ser Phe Thr Phe Glu Lys Gly Gly Lys Lys Tyr Thr 
    930                 935                 940                 


Ile Thr Ser Glu Gly Met Lys Leu Lys Asn Tyr Gly Asp Phe Phe Val 
945                 950                 955                 960 


Leu Ala Ser Asp Lys Arg Ile Gly Asn Leu Leu Glu Leu Val Gly Ser 
                965                 970                 975     


Asp Ile Val Ser Lys Glu Asp Ile Met Glu Glu Phe Asn Lys Tyr Asp 
            980                 985                 990         


Gln Cys Arg Pro Glu Ile Ser Ser  Ile Val Phe Asn Leu  Glu Lys Trp 
        995                 1000                 1005             


Ala Phe  Asp Thr Tyr Pro Glu  Leu Ser Ala Arg Val  Asp Arg Glu 
    1010                 1015                 1020             


Glu Lys  Val Asp Phe Lys Ser  Ile Leu Lys Ile Leu  Leu Asn Asn 
    1025                 1030                 1035             


Lys Asn  Ile Asn Lys Glu Gln  Ser Asp Ile Leu Arg  Lys Ile Arg 
    1040                 1045                 1050             


Asn Ala  Phe Asp His Asn Asn  Tyr Pro Asp Lys Gly  Val Val Glu 
    1055                 1060                 1065             


Ile Lys  Ala Leu Pro Glu Ile  Ala Met Ser Ile Lys  Lys Ala Phe 
    1070                 1075                 1080             


Gly Glu  Tyr Ala Ile Met Lys  Gly Ser Leu Gln 
    1085                 1090                 


<210>  127
<211>  3285
<212>  DNA
<213>  Prevotella buccalis

<400>  127
atgaacatcc ccgctctggt ggaaaaccag aagaagtact ttggcaccta cagcgtgatg       60

gccatgctga acgctcagac cgtgctggac cacatccaga aggtggccga tattgagggc      120

gagcagaacg agaacaacga gaatctgtgg tttcaccccg tgatgagcca cctgtacaac      180

gccaagaacg gctacgacaa gcagcccgag aaaaccatgt tcatcatcga gcggctgcag      240

agctacttcc cattcctgaa gatcatggcc gagaaccaga gagagtacag caacggcaag      300

tacaagcaga accgcgtgga agtgaacagc aacgacatct tcgaggtgct gaagcgcgcc      360

ttcggcgtgc tgaagatgta cagggacctg accaaccact acaagaccta cgaggaaaag      420

ctgaacgacg gctgcgagtt cctgaccagc acagagcaac ctctgagcgg catgatcaac      480

aactactaca cagtggccct gcggaacatg aacgagagat acggctacaa gacagaggac      540

ctggccttca tccaggacaa gcggttcaag ttcgtgaagg acgcctacgg caagaaaaag      600

tcccaagtga ataccggatt cttcctgagc ctgcaggact acaacggcga cacacagaag      660

aagctgcacc tgagcggagt gggaatcgcc ctgctgatct gcctgttcct ggacaagcag      720

tacatcaaca tctttctgag caggctgccc atcttctcca gctacaatgc ccagagcgag      780

gaacggcgga tcatcatcag atccttcggc atcaacagca tcaagctgcc caaggaccgg      840

atccacagcg agaagtccaa caagagcgtg gccatggata tgctcaacga agtgaagcgg      900

tgccccgacg agctgttcac aacactgtct gccgagaagc agtcccggtt cagaatcatc      960

agcgacgacc acaatgaagt gctgatgaag cggagcagcg acagattcgt gcctctgctg     1020

ctgcagtata tcgattacgg caagctgttc gaccacatca ggttccacgt gaacatgggc     1080

aagctgagat acctgctgaa ggccgacaag acctgcatcg acggccagac cagagtcaga     1140

gtgatcgagc agcccctgaa cggcttcggc agactggaag aggccgagac aatgcggaag     1200

caagagaacg gcaccttcgg caacagcggc atccggatca gagacttcga gaacatgaag     1260

cgggacgacg ccaatcctgc caactatccc tacatcgtgg acacctacac acactacatc     1320

ctggaaaaca acaaggtcga gatgtttatc aacgacaaag aggacagcgc cccactgctg     1380

cccgtgatcg aggatgatag atacgtggtc aagacaatcc ccagctgccg gatgagcacc     1440

ctggaaattc cagccatggc cttccacatg tttctgttcg gcagcaagaa aaccgagaag     1500

ctgatcgtgg acgtgcacaa ccggtacaag agactgttcc aggccatgca gaaagaagaa     1560

gtgaccgccg agaatatcgc cagcttcgga atcgccgaga gcgacctgcc tcagaagatc     1620

ctggatctga tcagcggcaa tgcccacggc aaggatgtgg acgccttcat cagactgacc     1680

gtggacgaca tgctgaccga caccgagcgg agaatcaaga gattcaagga cgaccggaag     1740

tccattcgga gcgccgacaa caagatggga aagagaggct tcaagcagat ctccacaggc     1800

aagctggccg acttcctggc caaggacatc gtgctgtttc agcccagcgt gaacgatggc     1860

gagaacaaga tcaccggcct gaactaccgg atcatgcaga gcgccattgc cgtgtacgat     1920

agcggcgacg attacgaggc caagcagcag ttcaagctga tgttcgagaa ggcccggctg     1980

atcggcaagg gcacaacaga gcctcatcca tttctgtaca aggtgttcgc ccgcagcatc     2040

cccgccaatg ccgtcgagtt ctacgagcgc tacctgatcg agcggaagtt ctacctgacc     2100

ggcctgtcca acgagatcaa gaaaggcaac agagtggatg tgcccttcat ccggcgggac     2160

cagaacaagt ggaaaacacc cgccatgaag accctgggca gaatctacag cgaggatctg     2220

cccgtggaac tgcccagaca gatgttcgac aatgagatca agtcccacct gaagtccctg     2280

ccacagatgg aaggcatcga cttcaacaat gccaacgtga cctatctgat cgccgagtac     2340

atgaagagag tgctggacga cgacttccag accttctacc agtggaaccg caactaccgg     2400

tacatggaca tgcttaaggg cgagtacgac agaaagggct ccctgcagca ctgcttcacc     2460

agcgtggaag agagagaagg cctctggaaa gagcgggcct ccagaacaga gcggtacaga     2520

aagcaggcca gcaacaagat ccgcagcaac cggcagatga gaaacgccag cagcgaagag     2580

atcgagacaa tcctggataa gcggctgagc aacagccgga acgagtacca gaaaagcgag     2640

aaagtgatcc ggcgctacag agtgcaggat gccctgctgt ttctgctggc caaaaagacc     2700

ctgaccgaac tggccgattt cgacggcgag aggttcaaac tgaaagaaat catgcccgac     2760

gccgagaagg gaatcctgag cgagatcatg cccatgagct tcaccttcga gaaaggcggc     2820

aagaagtaca ccatcaccag cgagggcatg aagctgaaga actacggcga cttctttgtg     2880

ctggctagcg acaagaggat cggcaacctg ctggaactcg tgggcagcga catcgtgtcc     2940

aaagaggata tcatggaaga gttcaacaaa tacgaccagt gcaggcccga gatcagctcc     3000

atcgtgttca acctggaaaa gtgggccttc gacacatacc ccgagctgtc tgccagagtg     3060

gaccgggaag agaaggtgga cttcaagagc atcctgaaaa tcctgctgaa caacaagaac     3120

atcaacaaag agcagagcga catcctgcgg aagatccgga acgccttcga tcacaacaat     3180

taccccgaca aaggcgtggt ggaaatcaag gccctgcctg agatcgccat gagcatcaag     3240

aaggcctttg gggagtacgc catcatgaag ggatcccttc aatga                     3285


<210>  128
<211>  20
<212>  DNA
<213>  Homo sapiens

<400>  128
gatgtcgcgt gtcgctgaaa                                                   20


<210>  129
<211>  20
<212>  DNA
<213>  Homo sapiens

<400>  129
caggagccga ccccgttcgt                                                   20


<210>  130
<211>  20
<212>  DNA
<213>  Homo sapiens

<400>  130
gtcggaacta ttggtcgaaa                                                   20


<210>  131
<211>  20
<212>  DNA
<213>  Homo sapiens

<400>  131
catggcacgt atgaccgctg                                                   20


<210>  132
<211>  20
<212>  DNA
<213>  Homo sapiens

<400>  132
acttataagt atagggaatc                                                   20


<210>  133
<211>  20
<212>  DNA
<213>  Homo sapiens

<400>  133
ggattagttg aaagactgcc                                                   20


<210>  134
<211>  20
<212>  DNA
<213>  Homo sapiens

<400>  134
gtccactaaa tgtgacgccc                                                   20


<210>  135
<211>  20
<212>  DNA
<213>  Homo sapiens

<400>  135
gaggacaagc cttgacattc                                                   20


<210>  136
<211>  20
<212>  DNA
<213>  Homo sapiens

<400>  136
tgcagtcaga tgttatcgtc                                                   20


<210>  137
<211>  20
<212>  DNA
<213>  Homo sapiens

<400>  137
tactggaact cctagatccg                                                   20


<210>  138
<211>  20
<212>  DNA
<213>  Homo sapiens

<400>  138
caatggtcct ttgtcaaacg                                                   20


<210>  139
<211>  20
<212>  DNA
<213>  Homo sapiens

<400>  139
tggcaacgtg aacaggtcca                                                   20


<210>  140
<211>  20
<212>  DNA
<213>  Homo sapiens

<400>  140
aacctgaata catggtaagg                                                   20


<210>  141
<211>  20
<212>  DNA
<213>  Homo sapiens

<400>  141
tactcttgct catcaagcag                                                   20


<210>  142
<211>  20
<212>  DNA
<213>  Homo sapiens

<400>  142
ctggatgagc aagcgctgta                                                   20


<210>  143
<211>  20
<212>  DNA
<213>  Homo sapiens

<400>  143
tcagagaagg actagaccga                                                   20


<210>  144
<211>  30
<212>  DNA
<213>  Homo sapiens

<400>  144
gctacgggga ggaagtgaaa gaattcttag                                        30


<210>  145
<211>  30
<212>  DNA
<213>  Homo sapiens

<400>  145
ggaaaggacc taaagtgtac cgccggaagc                                        30


<210>  146
<211>  30
<212>  DNA
<213>  Homo sapiens

<400>  146
ggcagtatgg acaaaaattc aattcgtcat                                        30


<210>  147
<211>  30
<212>  DNA
<213>  Homo sapiens

<400>  147
gataaactca aggagacact aacagcacat                                        30


<210>  148
<211>  20
<212>  DNA
<213>  Homo sapiens

<400>  148
ctgtcgtaga cagcttgtac                                                   20


<210>  149
<211>  20
<212>  DNA
<213>  Homo sapiens

<400>  149
cggtcgcaat ctgggtcacg                                                   20


<210>  150
<211>  19
<212>  DNA
<213>  Homo sapiens

<400>  150
gagacacccg cgcagaatc                                                    19


<210>  151
<211>  20
<212>  DNA
<213>  Homo sapiens

<400>  151
cgttctcaag cagcatctcc                                                   20


<210>  152
<211>  20
<212>  DNA
<213>  Homo sapiens

<400>  152
catctccgta ttgagtgcga                                                   20


<210>  153
<211>  20
<212>  DNA
<213>  Homo sapiens

<400>  153
cccgttaaca ttttaattgc                                                   20


<210>  154
<211>  20
<212>  DNA
<213>  Homo sapiens

<400>  154
actgtatagc tgtactcggg                                                   20


<210>  155
<211>  20
<212>  DNA
<213>  Homo sapiens

<400>  155
gtggaatgca ggtgtcatac                                                   20


<210>  156
<211>  20
<212>  DNA
<213>  Homo sapiens

<400>  156
catgttggta catccatccg                                                   20


<210>  157
<211>  20
<212>  DNA
<213>  Homo sapiens

<400>  157
gttgccggta taagagacag                                                   20


<210>  158
<211>  20
<212>  DNA
<213>  Homo sapiens

<400>  158
gacgcaagca ttaaaccggg                                                   20


<210>  159
<211>  20
<212>  DNA
<213>  Homo sapiens

<400>  159
ctgggtaaag ggtcgcccga                                                   20


<210>  160
<211>  20
<212>  DNA
<213>  Homo sapiens

<400>  160
cggaccgatc acctgagatg                                                   20


<210>  161
<211>  20
<212>  DNA
<213>  Homo sapiens

<400>  161
gccctagcgt cataccacaa                                                   20


<210>  162
<211>  20
<212>  DNA
<213>  Homo sapiens

<400>  162
gcacttactc aacggtctcg                                                   20


<210>  163
<211>  20
<212>  DNA
<213>  Homo sapiens

<400>  163
tactagccta ggaaatactg                                                   20


<210>  164
<211>  20
<212>  DNA
<213>  Homo sapiens

<400>  164
cgtacggaga acttgcagct                                                   20


<210>  165
<211>  20
<212>  DNA
<213>  Homo sapiens

<400>  165
gacgcttatc tgactcggcg                                                   20


