                         SEQUENCE LISTING

<110>  The University of Chicago
 
<120>  COMPOSITIONS AND METHODS FOR ACTIVATING NRF2-DEPENDENT GENE 
       EXPRESSION

<130>  ARCD.P0671WO

<150>  62/745,454
<151>  2018-10-14

<160>  69    

<170>  PatentIn version 3.5

<210>  1
<211>  624
<212>  PRT
<213>  Homo sapiens

<400>  1

Met Gln Pro Asp Pro Arg Pro Ser Gly Ala Gly Ala Cys Cys Arg Phe 
1               5                   10                  15      


Leu Pro Leu Gln Ser Gln Cys Pro Glu Gly Ala Gly Asp Ala Val Met 
            20                  25                  30          


Tyr Ala Ser Thr Glu Cys Lys Ala Glu Val Thr Pro Ser Gln His Gly 
        35                  40                  45              


Asn Arg Thr Phe Ser Tyr Thr Leu Glu Asp His Thr Lys Gln Ala Phe 
    50                  55                  60                  


Gly Ile Met Asn Glu Leu Arg Leu Ser Gln Gln Leu Cys Asp Val Thr 
65                  70                  75                  80  


Leu Gln Val Lys Tyr Gln Asp Ala Pro Ala Ala Gln Phe Met Ala His 
                85                  90                  95      


Lys Val Val Leu Ala Ser Ser Ser Pro Val Phe Lys Ala Met Phe Thr 
            100                 105                 110         


Asn Gly Leu Arg Glu Gln Gly Met Glu Val Val Ser Ile Glu Gly Ile 
        115                 120                 125             


His Pro Lys Val Met Glu Arg Leu Ile Glu Phe Ala Tyr Thr Ala Ser 
    130                 135                 140                 


Ile Ser Met Gly Glu Lys Cys Val Leu His Val Met Asn Gly Ala Val 
145                 150                 155                 160 


Met Tyr Gln Ile Asp Ser Val Val Arg Ala Cys Ser Asp Phe Leu Val 
                165                 170                 175     


Gln Gln Leu Asp Pro Ser Asn Ala Ile Gly Ile Ala Asn Phe Ala Glu 
            180                 185                 190         


Gln Ile Gly Cys Val Glu Leu His Gln Arg Ala Arg Glu Tyr Ile Tyr 
        195                 200                 205             


Met His Phe Gly Glu Val Ala Lys Gln Glu Glu Phe Phe Asn Leu Ser 
    210                 215                 220                 


His Cys Gln Leu Val Thr Leu Ile Ser Arg Asp Asp Leu Asn Val Arg 
225                 230                 235                 240 


Cys Glu Ser Glu Val Phe His Ala Cys Ile Asn Trp Val Lys Tyr Asp 
                245                 250                 255     


Cys Glu Gln Arg Arg Phe Tyr Val Gln Ala Leu Leu Arg Ala Val Arg 
            260                 265                 270         


Cys His Ser Leu Thr Pro Asn Phe Leu Gln Met Gln Leu Gln Lys Cys 
        275                 280                 285             


Glu Ile Leu Gln Ser Asp Ser Arg Cys Lys Asp Tyr Leu Val Lys Ile 
    290                 295                 300                 


Phe Glu Glu Leu Thr Leu His Lys Pro Thr Gln Val Met Pro Cys Arg 
305                 310                 315                 320 


Ala Pro Lys Val Gly Arg Leu Ile Tyr Thr Ala Gly Gly Tyr Phe Arg 
                325                 330                 335     


Gln Ser Leu Ser Tyr Leu Glu Ala Tyr Asn Pro Ser Asp Gly Thr Trp 
            340                 345                 350         


Leu Arg Leu Ala Asp Leu Gln Val Pro Arg Ser Gly Leu Ala Gly Cys 
        355                 360                 365             


Val Val Gly Gly Leu Leu Tyr Ala Val Gly Gly Arg Asn Asn Ser Pro 
    370                 375                 380                 


Asp Gly Asn Thr Asp Ser Ser Ala Leu Asp Cys Tyr Asn Pro Met Thr 
385                 390                 395                 400 


Asn Gln Trp Ser Pro Cys Ala Pro Met Ser Val Pro Arg Asn Arg Ile 
                405                 410                 415     


Gly Val Gly Val Ile Asp Gly His Ile Tyr Ala Val Gly Gly Ser His 
            420                 425                 430         


Gly Cys Ile His His Asn Ser Val Glu Arg Tyr Glu Pro Glu Arg Asp 
        435                 440                 445             


Glu Trp His Leu Val Ala Pro Met Leu Thr Arg Arg Ile Gly Val Gly 
    450                 455                 460                 


Val Ala Val Leu Asn Arg Leu Leu Tyr Ala Val Gly Gly Phe Asp Gly 
465                 470                 475                 480 


Thr Asn Arg Leu Asn Ser Ala Glu Cys Tyr Tyr Pro Glu Arg Asn Glu 
                485                 490                 495     


Trp Arg Met Ile Thr Ala Met Asn Thr Ile Arg Ser Gly Ala Gly Val 
            500                 505                 510         


Cys Val Leu His Asn Cys Ile Tyr Ala Ala Gly Gly Tyr Asp Gly Gln 
        515                 520                 525             


Asp Gln Leu Asn Ser Val Glu Arg Tyr Asp Val Glu Thr Glu Thr Trp 
    530                 535                 540                 


Thr Phe Val Ala Pro Met Lys His Arg Arg Ser Ala Leu Gly Ile Thr 
545                 550                 555                 560 


Val His Gln Gly Arg Ile Tyr Val Leu Gly Gly Tyr Asp Gly His Thr 
                565                 570                 575     


Phe Leu Asp Ser Val Glu Cys Tyr Asp Pro Asp Thr Asp Thr Trp Ser 
            580                 585                 590         


Glu Val Thr Arg Met Thr Ser Gly Arg Ser Gly Val Gly Val Ala Val 
        595                 600                 605             


Thr Met Glu Pro Cys Arg Lys Gln Ile Asp Gln Gln Asn Cys Thr Cys 
    610                 615                 620                 


<210>  2
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic oligonucleotide

<400>  2
gcctccttca tggcatagtt                                                   20


<210>  3
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic oligonucleotide

<400>  3
ggactgcacc agagccat                                                     18


<210>  4
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic oligonucleotide

<400>  4
gagtgtaagg acccatcgga                                                   20


<210>  5
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic oligonucleotide

<400>  5
gccagcaaca aagtgcaag                                                    19


<210>  6
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic oligonucleotide

<400>  6
ggagacgaaa tgcattcaca                                                   20


<210>  7
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic oligonucleotide

<400>  7
acgaattcat ggaggcagtt                                                   20


<210>  8
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic oligonucleotide

<400>  8
gcttcttgga aacttgcttc a                                                 21


<210>  9
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic oligonucleotide

<400>  9
ctgtgtgatg ccaccagatt                                                   20


<210>  10
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic oligonucleotide

<400>  10
tcagggccgt tcatttttag                                                   20


<210>  11
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic oligonucleotide

<400>  11
gatctgcccg ttgtgtttg                                                    19


<210>  12
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic oligonucleotide

<400>  12
ggcaaagttc ttcaaagcca                                                   20


<210>  13
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic oligonucleotide

<400>  13
catcaaccgc cagatcaac                                                    19


<210>  14
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic oligonucleotide

<400>  14
ttggaaagcc ataatcagca                                                   20


<210>  15
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic oligonucleotide

<400>  15
caagctgggt ggcacttg                                                     18


<210>  16
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic oligonucleotide

<400>  16
cttcacgtgg atgaagtgga                                                   20


<210>  17
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic oligonucleotide

<400>  17
ctggcggaat gaatttgact                                                   20


<210>  18
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic oligonucleotide

<400>  18
gggatctctt ccacactgga t                                                 21


<210>  19
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic oligonucleotide

<400>  19
catacaggcc ctgaagagga                                                   20


<210>  20
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic oligonucleotide

<400>  20
gggcacacaa aggtgaagtc                                                   20


<210>  21
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic oligonucleotide

<400>  21
gctgttatgc cagatggtca g                                                 21


<210>  22
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic oligonucleotide

<400>  22
tgcgtagtct ctcttcagcg                                                   20


<210>  23
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic oligonucleotide

<400>  23
gcaactccta gagcggtcct                                                   20


<210>  24
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic oligonucleotide

<400>  24
gggtgatctt gttcttccca                                                   20


<210>  25
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic oligonucleotide

<400>  25
ggggaagctc ctgactatga                                                   20


<210>  26
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic oligonucleotide

<400>  26
ccacaccttc actggtccat                                                   20


<210>  27
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic oligonucleotide

<400>  27
ctagcgagtt atggcgacg                                                    19


<210>  28
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic oligonucleotide

<400>  28
tcagggccgt tcatttttag                                                   20


<210>  29
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic oligonucleotide

<400>  29
gatctgcccg ttgtgtttg                                                    19


<210>  30
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic oligonucleotide

<400>  30
ctcaaaaggc ttcagttgcc                                                   20


<210>  31
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic oligonucleotide

<400>  31
acctccgctg caaatacatc                                                   20


<210>  32
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic oligonucleotide

<400>  32
ctttctcccc agacaggacc                                                   20


<210>  33
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic oligonucleotide

<400>  33
caaggacgtt ctcaagtggg                                                   20


<210>  34
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic oligonucleotide

<400>  34
tggattagcg tcattccaag                                                   20


<210>  35
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic oligonucleotide

<400>  35
gcggacccca gtaccaag                                                     18


<210>  36
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic oligonucleotide

<400>  36
cttgggacag cagccttaat                                                   20


<210>  37
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic oligonucleotide

<400>  37
caagctggac gttaaaggga                                                   20


<210>  38
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic oligonucleotide

<400>  38
atctgcctcc cggtctatg                                                    19


<210>  39
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic oligonucleotide

<400>  39
tacctgtcgg aacatggagg                                                   20


<210>  40
<211>  26
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic oligonucleotide

<400>  40
tgaacggtgc tgtcatgtac cagatc                                            26


<210>  41
<211>  28
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic oligonucleotide

<400>  41
cccctcagga gactgtgact gcaggggc                                          28


<210>  42
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic oligonucleotide

<400>  42
gccctcccag catggcaa                                                     18


<210>  43
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic oligonucleotide

<400>  43
gtcacctccg ccttggactc agt                                               23


<210>  44
<211>  26
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic oligonucleotide

<400>  44
tgaacggtgc tgtcatgtac cagatc                                            26


<210>  45
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic oligonucleotide

<400>  45
tgacgtggag gacagacttc tcgc                                              24


<210>  46
<211>  17
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic oligonucleotide

<400>  46
ccgaacttcc tgcagct                                                      17


<210>  47
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic oligonucleotide

<400>  47
cgtcaacgag tgggagcgca cg                                                22


<210>  48
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic oligonucleotide

<400>  48
gtccgactcc cgctgcaagg act                                               23


<210>  49
<211>  26
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic oligonucleotide

<400>  49
tgcaggatct cggacttctg cagctt                                            26


<210>  50
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic oligonucleotide

<400>  50
gaccaatcag tggtcgccct g                                                 21


<210>  51
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic oligonucleotide

<400>  51
atggggttgt aagagtccag ggc                                               23


<210>  52
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic oligonucleotide

<400>  52
cgtgccccgt aaccgcatcg                                                   20


<210>  53
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic oligonucleotide

<400>  53
ctcatggggg cgctgggcg                                                    19


<210>  54
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic oligonucleotide

<400>  54
gccctcccag catggcaa                                                     18


<210>  55
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic oligonucleotide

<400>  55
gtcacctccg ccctgcactc agt                                               23


<210>  56
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic oligonucleotide

<400>  56
gccctcccag catggcaa                                                     18


<210>  57
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic oligonucleotide

<400>  57
gtcacctccg ccatgcactc agt                                               23


<210>  58
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic oligonucleotide

<400>  58
gccctcccag catggcaa                                                     18


<210>  59
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic oligonucleotide

<400>  59
gtcacctccg ccatggactc agt                                               23


<210>  60
<211>  26
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic oligonucleotide

<400>  60
tgaacggtgc tgtcatgtac cagatc                                            26


<210>  61
<211>  25
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic oligonucleotide

<400>  61
tgacgtggag gacacacatc tcgcc                                             25


<210>  62
<211>  29
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic oligonucleotide

<400>  62
gcagccagat cccgcgccta gcggggctg                                         29


<210>  63
<211>  29
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic oligonucleotide

<400>  63
cagccccgct aggcgcggga tctggctgc                                         29


<210>  64
<211>  28
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic oligonucleotide

<400>  64
gggcctgctg cgcattcctg cccctgca                                          28


<210>  65
<211>  28
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic oligonucleotide

<400>  65
tgcaggggca ggaatgcgca gcaggccc                                          28


<210>  66
<211>  33
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic oligonucleotide

<400>  66
ctcccagcat ggcaacgcca ccttcagcta cac                                    33


<210>  67
<211>  33
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic oligonucleotide

<400>  67
gtgtagctga aggtggcgtt gccatgctgg gag                                    33


<210>  68
<211>  34
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic oligonucleotide

<400>  68
cccaaggtca tggaggccct cattgaattc gcct                                   34


<210>  69
<211>  34
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic oligonucleotide

<400>  69
aggcgaattc aatgagggcc tccatgacct tggg                                   34


