                         SEQUENCE LISTING

<110>  Dana-Farber Cancer Institute, Inc.
 
<120>  NON-CANONICAL SWI/SNF COMPLEX AND USES THEREOF

<130>  DFS-24725

<140>  PCT/US2019/056312
<141>  2019-10-15

<150>  US 60/746,944
<151>  2018-10-17

<160>  55    

<170>  PatentIn version 3.5

<210>  1
<211>  5780
<212>  DNA
<213>  Homo sapiens

<400>  1
ctgggcgggg ccgggaagcg gcagtggcgg ctacgcgcgc gggggtgcgc gcgggaacga       60

ccgggaaaca ccgcgagggc cggggtgggc caggctgtgg ggacgacggg ctgcgacgat      120

ggccgcagcg gcgggcggcg gcgggccggg gacagcggta ggcgccacgg gctcggggat      180

tgcggcggca gccgcaggcc tagctgttta tcgacggaag gatgggggcc cggccaccaa      240

gttttgggag agcccggaga cggtgtccca gctggattcg gtgcgggtct ggctgggcaa      300

gcactacaag aagtatgttc atgcggatgc tcctaccaat aaaacactgg ctgggctggt      360

ggtgcagctt cttcagttcc aggaagatgc ctttgggaag catgtcacca acccggcctt      420

caccaaactc cctgcaaagt gtttcatgga tttcaaagct ggaggcgcct tatgtcacat      480

tcttggggct gcttacaagt ataaaaatga acagggatgg cggaggtttg acctacagaa      540

cccatctcga atggatcgta atgtggaaat gtttatgaac attgaaaaaa cattggtgca      600

gaacaattgt ttgaccagac ccaacatcta cctcattcca gacattgatc tgaagttggc      660

taacaaattg aaagatatca tcaaacgaca tcagggaaca tttacggatg agaagtcaaa      720

agcttcccac cacatttacc catattcttc ctcacaagac gatgaagaat ggttgagacc      780

ggtgatgaga aaagagaagc aagtgttagt gcattggggc ttttacccag acagctatga      840

tacttgggtc catagtaatg atgttgatgc tgaaattgaa gatccaccaa ttccagaaaa      900

accatggaag gttcatgtga aatggatttt ggacactgat attttcaatg aatggatgaa      960

tgaggaggat tatgaggtgg atgaaaatag gaagcctgtg agttttcgtc agcggatttc     1020

aaccaagaat gaagagccag tcagaagtcc agaaagaaga gatagaaaag catcagctaa     1080

tgctcgaaag aggaaacatt cgccttcgcc tccccctccg acaccaacag aatcacggaa     1140

gaagagtggg aagaaaggcc aagctagcct ttatgggaag cgcagaagtc agaaagagga     1200

agatgagcaa gaagatctaa ccaaggatat ggaagaccca acacctgtac ccaatataga     1260

agaagtagta cttcccaaaa atgtgaacct aaagaaagat agtgaaaata cacctgttaa     1320

aggaggaact gtagcggatc tagatgagca ggatgaagaa acagtcacag caggaggaaa     1380

ggaagatgaa gatcctgcca aaggtgatca gagtcgatca gttgaccttg gggaagataa     1440

tgtgacagag cagaccaatc acattattat tcctagttat gcatcatggt ttgattataa     1500

ctgtattcat gtgattgaac ggcgtgctct tcctgagttc ttcaatggaa aaaacaaatc     1560

caagactcca gaaatatact tggcatatcg aaattttatg attgacacgt atcgtctaaa     1620

cccccaagag tatttaacta gcactgcttg tcggaggaac ttgactggag atgtgtgtgc     1680

tgtgatgagg gtccatgcct ttttagagca gtggggactc gttaattacc aagttgaccc     1740

ggaaagtaga cccatggcaa tgggacctcc tcctactcct cattttaatg tattagctga     1800

taccccctct gggcttgtgc ctctgcatct tcgatcacct caggttcctg ctgctcaaca     1860

gatgctaaat tttcctgaga aaaacaagga aaaaccagtt gatttgcaga actttggtct     1920

ccgtactgac atttactcca agaaaacatt agcaaagagt aaaggtgcta gtgctggaag     1980

agaatggact gaacaggaga cccttctact cctggaggcc ctggagatgt acaaggatga     2040

ttggaacaaa gtgtcggaac atgttggaag tcgtactcag gatgaatgca tcctccactt     2100

tttgagactt cccattgagg acccatacct tgagaattca gatgcttccc ttgggccttt     2160

ggcctaccag cctgtcccct tcagtcagtc aggaaatcca gttatgagta ctgttgcttt     2220

tttggcatct gtggtggacc ctcgcgtggc atctgctgca gcaaaagcgg ctttggagga     2280

gttttctcgg gtccgggagg aggtaccact ggaattggtt gaagctcatg tcaagaaagt     2340

acaagaagca gcacgagcct ctgggaaagt ggatcccacc tacggtctgg agagcagctg     2400

cattgcaggc acagggcccg atgagccaga gaagcttgaa ggagctgaag aggaaaaaat     2460

ggaagccgac cctgatggtc agcagcctga aaaggcagaa aataaagtgg aaaatgaaac     2520

ggatgaaggt gataaagcac aagatggaga aaatgaaaaa aatagtgaaa aggaacagga     2580

tagtgaagtg agtgaggata ccaaatcaga agaaaaggag actgaagaga acaaagaact     2640

cactgataca tgtaaagaaa gagaaagtga tactgggaag aagaaagtag aacatgaaat     2700

ttccgaagga aatgttgcca cagccgcagc agctgctctt gcctcagcgg ctaccaaagc     2760

caagcacctg gctgcagtgg aagaaagaaa gatcaagtcc ctggtagctc tcttggttga     2820

gacacaaatg aagaaactag agatcaaact tcgacatttt gaagagctgg aaactatcat     2880

ggacagagag aaagaagctc tagaacaaca gaggcagcag ttgcttactg aacgccaaaa     2940

cttccacatg gaacagctga agtatgctga attacgagca cgacagcaaa tggaacagca     3000

gcagcatggc cagaaccctc aacaggcaca ccagcactca ggaggacctg gcctggcccc     3060

acttggagca gcagggcacc ctggcatgat gcctcatcaa cagccccctc cctaccctct     3120

gatgcaccac cagatgccac cacctcatcc accccagcca ggtcagatac caggcccagg     3180

ttccatgatg cccgggcagc acatgccagg ccgcatgatt cccactgttg cagccaacat     3240

ccacccctct gggagtggcc ctacccctcc tggcatgcca ccaatgccag gaaacatctt     3300

aggaccccgg gtacccctga cagcacctaa cggcatgtat ccccctccac cacagcagca     3360

gccaccgcca ccaccacctg cagatggggt ccctccgcct cctgctcctg gcccgccagc     3420

ctcagctgct ccttagcctg gaagatgcag ggaacctcca cgcccaccac catgagctgg     3480

agtggggatg acaagacttg tgttcctcaa ctttcttggg tttctttcag gatttttctt     3540

ctcacagctc caagcacgtg tcccgtgcct ccccactcct cttaccaccc ctctctctga     3600

cactttttgt gttgggtcct cagccaacac tcaaggggaa acctgtagtg acagtgtgcc     3660

ctggtcatcc ttaaaataac ctgcatctcc cctgtcctgg tgtgggagta agctgacagt     3720

ttctctgcag gtcctgtcaa ctttagcatg ctatgtcttt accatttttg ctctcttgca     3780

gttttttgct ttgtcttatg cttctatgga taatgctata taatcattat ctttttatct     3840

ttctgttatt attgttttaa aggagagcat cctaagttaa taggaaccaa aaaataatga     3900

tgggcagaag ggggggaata gccacagggg acaaacctta aggcattata agtgacctta     3960

tttctgcttt tctgagctaa gaatggtgct gatggtaaag tttgagactt ttgccacaca     4020

caaatttgtg aaaattaaac gagatgtgga aggagaacct cagtgatttt attccctagt     4080

gaggcctctg agggcctcca cactgcctgg cagaacatac cactgaacta gtatgtgcta     4140

gaggagggca caaacatccg ctccttccct aggcctgctg gctctggttt tctatgcaga     4200

tgattcattg gattgggggt gagtgttttg tttttctggg ggcagtgtga gctttgaggg     4260

ttggaatatt gggaggcatt ccttagtttc ctcaactagc ctggaaagtt aggagtctag     4320

ggtaattacc cccaatgagt ctagcctact attcactgct ttgtgtgcat ttttttctcc     4380

ctctttaaaa aaccctttaa aagaaaaaaa aaagtagata gtgctaaata ttttagctca     4440

tgaaacttgg ttaggatggc tgggggtaca agtccccaaa ctacctcttg ttacagtagc     4500

cagggagtgg aatttcgtca accggtactt ttaaggttag gatgggacgg gaaaagtgaa     4560

gcaggatatt agctccttat accttctccc ttccatttct gagatctcac attccatcta     4620

tcacagggtt ttcaaagaga tgctgagggt aacaaggaac tcacttggca gtcagagcat     4680

catgctttga ggtttggggt gctcaggctg ggagggtaga atgccattcc agaggacaag     4740

ccacaaaaat gccttaattt gagctcgtat ttacccctgc tgataagtga cttgagagtt     4800

cccggttttt tcctcttgtc cttccctccc ttctgtcctt ccatgtgtgg ggaaagggtg     4860

tttttggtag agcttggttt ccaaagcgcc tggctttctc acttcacatt ctcaagtggc     4920

agtttcatta tttagaatgc aaggtggaca tcttttggat atctttttct atatattttc     4980

taaagcttta catatgagag ggtataggga ggtgtttata aaacacttga gaactttttt     5040

ccttaatatc agaaagcaaa aaaataaaac cacaattgag atttgccttt caaaccctca     5100

ggtttgcctc taaccaggtg tccctggtca ccatcagagt actggaatac gggaaccgag     5160

gagaccttgg tccttttgtt tttgttctgg actcttggga gtggaaatga gaatgagttt     5220

attcctactg gagcttagtt ccaatgcatt tggctccaga aagaccccag tgccttttga     5280

caatggccag ggttttacct acttcctgcc agtctttccc aaaggaaact cattccaaat     5340

acttcttttt tcccctggag tccgagaagg aaaatggaat tctggttcat actgtggtcc     5400

cttgtaacct caggtcttta atgtgatcac tttcaaattt aaaagatcca ggtggaaata     5460

tttttactat agtaataatt ctacaaaata cctgaattct taacactgtt atatttcagt     5520

ataagtggtg gctttttctt ttcatgtctt tgatctggtt ttattcctgt aattcagcca     5580

cctgattttg tgaggggggg gaataatatg tggtttttgt acaaacatgt ttctcagtgt     5640

gttgttattt tggaaaaaat gaggggaggg agtttggcaa gaatggagaa aatgaatgaa     5700

gaaggcctaa tctctctctt tttcagtgaa taaatggaac accatttctg gattctaaaa     5760

aaaaaaaaaa aaaaaaaaaa                                                 5780


<210>  2
<211>  1104
<212>  PRT
<213>  Homo sapiens

<400>  2

Met Ala Ala Ala Ala Gly Gly Gly Gly Pro Gly Thr Ala Val Gly Ala 
1               5                   10                  15      


Thr Gly Ser Gly Ile Ala Ala Ala Ala Ala Gly Leu Ala Val Tyr Arg 
            20                  25                  30          


Arg Lys Asp Gly Gly Pro Ala Thr Lys Phe Trp Glu Ser Pro Glu Thr 
        35                  40                  45              


Val Ser Gln Leu Asp Ser Val Arg Val Trp Leu Gly Lys His Tyr Lys 
    50                  55                  60                  


Lys Tyr Val His Ala Asp Ala Pro Thr Asn Lys Thr Leu Ala Gly Leu 
65                  70                  75                  80  


Val Val Gln Leu Leu Gln Phe Gln Glu Asp Ala Phe Gly Lys His Val 
                85                  90                  95      


Thr Asn Pro Ala Phe Thr Lys Leu Pro Ala Lys Cys Phe Met Asp Phe 
            100                 105                 110         


Lys Ala Gly Gly Ala Leu Cys His Ile Leu Gly Ala Ala Tyr Lys Tyr 
        115                 120                 125             


Lys Asn Glu Gln Gly Trp Arg Arg Phe Asp Leu Gln Asn Pro Ser Arg 
    130                 135                 140                 


Met Asp Arg Asn Val Glu Met Phe Met Asn Ile Glu Lys Thr Leu Val 
145                 150                 155                 160 


Gln Asn Asn Cys Leu Thr Arg Pro Asn Ile Tyr Leu Ile Pro Asp Ile 
                165                 170                 175     


Asp Leu Lys Leu Ala Asn Lys Leu Lys Asp Ile Ile Lys Arg His Gln 
            180                 185                 190         


Gly Thr Phe Thr Asp Glu Lys Ser Lys Ala Ser His His Ile Tyr Pro 
        195                 200                 205             


Tyr Ser Ser Ser Gln Asp Asp Glu Glu Trp Leu Arg Pro Val Met Arg 
    210                 215                 220                 


Lys Glu Lys Gln Val Leu Val His Trp Gly Phe Tyr Pro Asp Ser Tyr 
225                 230                 235                 240 


Asp Thr Trp Val His Ser Asn Asp Val Asp Ala Glu Ile Glu Asp Pro 
                245                 250                 255     


Pro Ile Pro Glu Lys Pro Trp Lys Val His Val Lys Trp Ile Leu Asp 
            260                 265                 270         


Thr Asp Ile Phe Asn Glu Trp Met Asn Glu Glu Asp Tyr Glu Val Asp 
        275                 280                 285             


Glu Asn Arg Lys Pro Val Ser Phe Arg Gln Arg Ile Ser Thr Lys Asn 
    290                 295                 300                 


Glu Glu Pro Val Arg Ser Pro Glu Arg Arg Asp Arg Lys Ala Ser Ala 
305                 310                 315                 320 


Asn Ala Arg Lys Arg Lys His Ser Pro Ser Pro Pro Pro Pro Thr Pro 
                325                 330                 335     


Thr Glu Ser Arg Lys Lys Ser Gly Lys Lys Gly Gln Ala Ser Leu Tyr 
            340                 345                 350         


Gly Lys Arg Arg Ser Gln Lys Glu Glu Asp Glu Gln Glu Asp Leu Thr 
        355                 360                 365             


Lys Asp Met Glu Asp Pro Thr Pro Val Pro Asn Ile Glu Glu Val Val 
    370                 375                 380                 


Leu Pro Lys Asn Val Asn Leu Lys Lys Asp Ser Glu Asn Thr Pro Val 
385                 390                 395                 400 


Lys Gly Gly Thr Val Ala Asp Leu Asp Glu Gln Asp Glu Glu Thr Val 
                405                 410                 415     


Thr Ala Gly Gly Lys Glu Asp Glu Asp Pro Ala Lys Gly Asp Gln Ser 
            420                 425                 430         


Arg Ser Val Asp Leu Gly Glu Asp Asn Val Thr Glu Gln Thr Asn His 
        435                 440                 445             


Ile Ile Ile Pro Ser Tyr Ala Ser Trp Phe Asp Tyr Asn Cys Ile His 
    450                 455                 460                 


Val Ile Glu Arg Arg Ala Leu Pro Glu Phe Phe Asn Gly Lys Asn Lys 
465                 470                 475                 480 


Ser Lys Thr Pro Glu Ile Tyr Leu Ala Tyr Arg Asn Phe Met Ile Asp 
                485                 490                 495     


Thr Tyr Arg Leu Asn Pro Gln Glu Tyr Leu Thr Ser Thr Ala Cys Arg 
            500                 505                 510         


Arg Asn Leu Thr Gly Asp Val Cys Ala Val Met Arg Val His Ala Phe 
        515                 520                 525             


Leu Glu Gln Trp Gly Leu Val Asn Tyr Gln Val Asp Pro Glu Ser Arg 
    530                 535                 540                 


Pro Met Ala Met Gly Pro Pro Pro Thr Pro His Phe Asn Val Leu Ala 
545                 550                 555                 560 


Asp Thr Pro Ser Gly Leu Val Pro Leu His Leu Arg Ser Pro Gln Val 
                565                 570                 575     


Pro Ala Ala Gln Gln Met Leu Asn Phe Pro Glu Lys Asn Lys Glu Lys 
            580                 585                 590         


Pro Val Asp Leu Gln Asn Phe Gly Leu Arg Thr Asp Ile Tyr Ser Lys 
        595                 600                 605             


Lys Thr Leu Ala Lys Ser Lys Gly Ala Ser Ala Gly Arg Glu Trp Thr 
    610                 615                 620                 


Glu Gln Glu Thr Leu Leu Leu Leu Glu Ala Leu Glu Met Tyr Lys Asp 
625                 630                 635                 640 


Asp Trp Asn Lys Val Ser Glu His Val Gly Ser Arg Thr Gln Asp Glu 
                645                 650                 655     


Cys Ile Leu His Phe Leu Arg Leu Pro Ile Glu Asp Pro Tyr Leu Glu 
            660                 665                 670         


Asn Ser Asp Ala Ser Leu Gly Pro Leu Ala Tyr Gln Pro Val Pro Phe 
        675                 680                 685             


Ser Gln Ser Gly Asn Pro Val Met Ser Thr Val Ala Phe Leu Ala Ser 
    690                 695                 700                 


Val Val Asp Pro Arg Val Ala Ser Ala Ala Ala Lys Ala Ala Leu Glu 
705                 710                 715                 720 


Glu Phe Ser Arg Val Arg Glu Glu Val Pro Leu Glu Leu Val Glu Ala 
                725                 730                 735     


His Val Lys Lys Val Gln Glu Ala Ala Arg Ala Ser Gly Lys Val Asp 
            740                 745                 750         


Pro Thr Tyr Gly Leu Glu Ser Ser Cys Ile Ala Gly Thr Gly Pro Asp 
        755                 760                 765             


Glu Pro Glu Lys Leu Glu Gly Ala Glu Glu Glu Lys Met Glu Ala Asp 
    770                 775                 780                 


Pro Asp Gly Gln Gln Pro Glu Lys Ala Glu Asn Lys Val Glu Asn Glu 
785                 790                 795                 800 


Thr Asp Glu Gly Asp Lys Ala Gln Asp Gly Glu Asn Glu Lys Asn Ser 
                805                 810                 815     


Glu Lys Glu Gln Asp Ser Glu Val Ser Glu Asp Thr Lys Ser Glu Glu 
            820                 825                 830         


Lys Glu Thr Glu Glu Asn Lys Glu Leu Thr Asp Thr Cys Lys Glu Arg 
        835                 840                 845             


Glu Ser Asp Thr Gly Lys Lys Lys Val Glu His Glu Ile Ser Glu Gly 
    850                 855                 860                 


Asn Val Ala Thr Ala Ala Ala Ala Ala Leu Ala Ser Ala Ala Thr Lys 
865                 870                 875                 880 


Ala Lys His Leu Ala Ala Val Glu Glu Arg Lys Ile Lys Ser Leu Val 
                885                 890                 895     


Ala Leu Leu Val Glu Thr Gln Met Lys Lys Leu Glu Ile Lys Leu Arg 
            900                 905                 910         


His Phe Glu Glu Leu Glu Thr Ile Met Asp Arg Glu Lys Glu Ala Leu 
        915                 920                 925             


Glu Gln Gln Arg Gln Gln Leu Leu Thr Glu Arg Gln Asn Phe His Met 
    930                 935                 940                 


Glu Gln Leu Lys Tyr Ala Glu Leu Arg Ala Arg Gln Gln Met Glu Gln 
945                 950                 955                 960 


Gln Gln His Gly Gln Asn Pro Gln Gln Ala His Gln His Ser Gly Gly 
                965                 970                 975     


Pro Gly Leu Ala Pro Leu Gly Ala Ala Gly His Pro Gly Met Met Pro 
            980                 985                 990         


His Gln Gln Pro Pro Pro Tyr Pro  Leu Met His His Gln  Met Pro Pro 
        995                 1000                 1005             


Pro His  Pro Pro Gln Pro Gly  Gln Ile Pro Gly Pro  Gly Ser Met 
    1010                 1015                 1020             


Met Pro  Gly Gln His Met Pro  Gly Arg Met Ile Pro  Thr Val Ala 
    1025                 1030                 1035             


Ala Asn  Ile His Pro Ser Gly  Ser Gly Pro Thr Pro  Pro Gly Met 
    1040                 1045                 1050             


Pro Pro  Met Pro Gly Asn Ile  Leu Gly Pro Arg Val  Pro Leu Thr 
    1055                 1060                 1065             


Ala Pro  Asn Gly Met Tyr Pro  Pro Pro Pro Gln Gln  Gln Pro Pro 
    1070                 1075                 1080             


Pro Pro  Pro Pro Ala Asp Gly  Val Pro Pro Pro Pro  Ala Pro Gly 
    1085                 1090                 1095             


Pro Pro  Ala Ser Ala Pro 
    1100                 


<210>  3
<211>  5684
<212>  DNA
<213>  Mus musculus

<400>  3
ggaggtggca tctgcgcgcg cgcgcgcggg tgcgaacggg aaacgccgcg agggccaggc       60

taggccgggc ggtagacacg acggacggtg actatggccg cgacagcggg tggcggtccg      120

ggagcagcag caggcgccgt gggtgcaggg ggtgcggcgg cggcctccgg gctggccgtg      180

taccggagga aggacggggg cccggccagc aagttttggg agagcccgga cacggtgtcc      240

cagctagatt cggtgcgagt ctggctgggc aagcactaca agaagtatgt tcatgcagat      300

gctcctacca ataaaacact agctggactg gtggtgcagc ttctacagtt ccaagaagat      360

gcctttggga agcatgtcac caacccagct ttcaccaaac tacctgcaaa atgtttcatg      420

gatttcaaag ctggaggcac cttgtgtcac attcttgggg cagcttacaa gtacaaaaat      480

gaacagggct ggcggagatt tgatcttcag aacccatccc gaatggatcg taacgttgaa      540

atgttcatga acattgagaa aacattggta cagaacaact gtctgactag accaaacatc      600

tacctcattc cagacattga tttgaagttg gctaacaagt tgaaagatat catcaaacgg      660

catcagggga catttactga tgagaagtca aaagcttccc accatattta tccatatcct      720

tcctcacaag aggatgagga gtggctgaga ccagtgatga ggagagacaa gcaggtgctg      780

gtgcactggg gtttctaccc agacagctat gacacttggg tccacagtaa tgatgttgat      840

gctgaaattg aagatgcacc aatcccagaa aagccctgga aggttcatgt aaaatggatt      900

ttggacactg acgttttcaa tgaatggatg aatgaagagg attatgaagt ggatgagaac      960

agaaagccag tgagctttcg tcaacgaatt tcaacaaaga atgaagagcc agtcagaagt     1020

ccagaaagga gagacagaaa agcctctgcc aactctagga agaggaaacc ttccccttct     1080

cctcctcctc ccacagccac agagtcccgc aagaagagcg ggaagaaagg acaagctagc     1140

ctttatggga aacgtagaag tcagaaggaa gaagatgagc aagaagatct taccaaggac     1200

atggaagacc ccacacctgt acctaacata gaggaagtgg ttctccctaa gaatgtaaac     1260

ccaaagaagg acagtgaaaa cacacccgtt aaaggaggca cggtggcaga tctagatgag     1320

caggatgaag aagcagttac aacaggagga aaggaagatg aagatcccag caaaggtgat     1380

ccaagtcgct cagttgaccc aggtgaagac aacgtgacag aacagaccaa tcacatcatt     1440

attcccagct acgcatcctg gtttgattat aattgtattc atgtcattga acggcgtgcg     1500

cttcctgagt tctttaatgg aaaaaacaaa tccaagaccc ctgaaatata cttggcatat     1560

cgaaatttta tgattgacac ataccgtcta aaccctcaag aatatttaac cagcactgct     1620

tgccggcgaa acctgactgg agatgtgtgt gctgtgatga gggttcatgc cttcttagag     1680

cagtggggtc ttgttaacta ccaagttgac ccagagagtc gacccatggc aatgggacct     1740

cctcccactc ctcacttcaa tgtgttagct gacacaccct ctgggcttgt gcccctgcat     1800

cttcgatcac ctcaggtccc tgccgctcaa cagatgttaa attttcctga gaagaacaag     1860

gaaaaaccaa ttgatttgca gaactttggt cttcgaactg acatttactc caagaaaaca     1920

ctggcaaaga gtaaaggtgc tagtgctgga agggagtgga cagaacagga gacccttctt     1980

ctcctagagg ctctggagat gtacaaggac gattggaata aagtgtcaga acatgttgga     2040

agccgtactc aggacgaatg catcctccac tttctgaggc ttcccattga ggacccttac     2100

cttgaaaatt cagatgcttc tcttgggcca ctggcttacc agcctgtccc tttcagccag     2160

tcgggaaacc cggtgatgag cactgttgcc tttttagcat ctgtcgttga cccccgtgta     2220

gcatctgctg cagcaaaagc agcgttggag gagttttctc gtgtccgaga agaagtaccc     2280

ctggaattgg ttgaagcaca tgtcaagaaa gtacaggaag ctgcaagagc ctctgggaag     2340

gtggacccca cctatggctt ggagagcagc tgtattgctg gcacagggcc tgacgagcca     2400

gagaagcttg aaggatctga agaagagaag atggaaacag atcctgatgg tcagcagcct     2460

gaaaaggcag aaaacaaagt ggaaaatgaa tcggatgaag gtgataaaat acaagatcga     2520

gagaatgaaa aaaacactga gaaggaacaa gatagtgacg tcagtgagga tgtcaagcca     2580

gaagaaaagg agaatgaaga gaacaaagag ctcactgata catgtaaaga aagagaaagc     2640

gatgccggga agaagaaagt ggaacacgag atttcggaag gaaacgttgc cacagccgca     2700

gcagctgctc tggcctcagc tgctactaaa gccaagcacc tggcggctgt tgaagaaaga     2760

aaaatcaagt ccttggtagc tctcttggtt gaaacacaaa tgaagaaact agagatcaaa     2820

cttcgacatt ttgaagagct ggagactata atggacagag agaaagaggc tctagaacaa     2880

cagagacagc agttgcttac tgagcgtcag aacttccaca tggaacagtt gaaatatgct     2940

gaactacgtg cccggcagca aatggagcag cagcagcagc atggccagac acctcagcag     3000

gcgcaccagc acacgggagg gccggggatg gccccacttg gagccacagg ccaccctggc     3060

atgatgccgc atcagcagcc ccctccctac ccactgatgc accatcagat gccgccaccc     3120

catcctcccc aaccaggtca aataccaggc cctggctcca tgatgcctgg ccagcccatg     3180

ccaggtcgca tgatccccgc tgtggcagcc aacattcacc ctactgggag tggccctacc     3240

cctcctggta tgcctccaat gcccggaaac atcttaggac cccgggtacc cctcacagca     3300

ccaaacggca tgtatcctcc tccaccacag cagcagcagc cgcctcctcc tgcagatggg     3360

gtccctccac ctcctgctcc aggcccaccc gcctcggcca ctccctagcc tggaagatac     3420

aagagcctcc acagccacca caagcaggaa tggggatggc aggacttgtg tctcggcttc     3480

cttggttttc ttgcaggatt tttttttcac aaccccaagc acaagcccca tgtctctcca     3540

ctccttgata cttcttgtgt caggtcctta gttgacactc attgggaagc ctgtggtgac     3600

tgatgtgctc tggtcattta aaaagtacca tgtgtctccc ctgtccccgt gtgacagatg     3660

ttggcaggtg gtctgcaggt cctgttgtgt tgacattagt attctttgtg tgtatctctc     3720

tctgtctctc tctctctgct ttgtctaagg cttcaatgta taatcctcta taattattgt     3780

cctttcttcc tttgtaatgg ttgttttttt aaggaaagta tcctaagtta atagaaacca     3840

aaaaaaatgg taatgggcag aaagagatag ccacagaggg acacacctta aggcattata     3900

agtgacctta tttctgctta tctgagctag agtggtgcta ctgatagagt ccctgagact     3960

tgtcacacat aagtgcacca agatgagaag agctggggaa agggggtatc ctttcgattt     4020

gatttcctgg tgaggaccat gaaggacttc cctgtgcctg gaagaacatg ccactgtacc     4080

tagtacacga tagatagcaa agagcacagc tttacaacaa gcccttccta ccttctcccg     4140

ccattctggt tgtctgtgca gaagatttgc aggattggaa catggtggtt gttttcccaa     4200

gggcagcgtg agctttcaga gttggggttt tcccagtcta acaaagataa agggtctggg     4260

gccctaccta caaaccttta ggaacccttc caaacctccc aaccttcccc aaacacatag     4320

ggcctaccct cgccacccca ataaacatta catgtttttt aaaccttcct ataagaaagg     4380

aaaaaaatgt aaaatgggtt atagattatg ttgaacattt tatctcatgc ggcttggtgg     4440

gggtgggggt acagatccct aaactacctc ttgctgtagc cagggtgagc ggggttctta     4500

agcggtactg aggtgcagaa cgggagtggg aatgctcaca tgtgatgagc agcctcctgt     4560

acctcacatt ctgagacctc acattccatc tgttgtcaca gggttatgga gactgtgcta     4620

atggcacaag gacctcactt ggctccagag tgcgaggctg taaggtttaa gtgccatccc     4680

agaggaattg ccaccaaaaa aaaaaaaaaa agccttaatc tgagcctgta tctacccctg     4740

ctgatgaaca actagatggg ttttggtttt gccagcttct ttcctccctc cctccctccc     4800

tccctccctc cctccctcct ttctgtcttt ccattagtag caaaagggtg tttttagcag     4860

aactttaagt ggcagtttca ttcttgagag tgcaaggtag agcaccttac gggtgtattt     4920

ttatgtgtat tttaaagctt tatgtatgag agctataggt aggcatttct taataacaca     4980

aaaacctaca gttgagattt gcctttaaga ctcttggttt tcctctaacc aggagcccac     5040

gtcaccgcca gagtcctgga gctagagcta atgactccag agccttgggg tggaaatgga     5100

gattcgctta ttccctgggt gcttgttttt cctccaggaa aaccccggtg tcttctgacc     5160

gcagccaggg ttgccctcct tccctccatt ctctcccaaa gtaaattgac tccagcactt     5220

gccttctccc cggagtccta ggggaggtat aggactctgc ttgtctgtaa cctgaggtct     5280

gtaatgtgat tgctttccag ttttgagaga tgcaagtggg aatagttttt acattgttga     5340

taatctatag aacctaagtt caacacttca acacagctct ttccatgact gtcagttagg     5400

tatcattcct gtaataacac ccatccagtt ttgtgagggg cgggcttgga tactgtgtgg     5460

tttttgtaca aatgtgtttc tcagtgtggg tttttgtttt ttgttgggtt tttttttttt     5520

ttttggtgtt tttttgtttg tttatttgtt ttttttcttt aggttttgtt ctaatgaggt     5580

aaaggagctt tgagagtttg ggagaaaatg aatgaaagtg gcttaatgtc cctcgtttgc     5640

attgaataaa tgaaatacca tttatgaatt ctaaaaaaaa aaaa                      5684


<210>  4
<211>  1104
<212>  PRT
<213>  Mus musculus

<400>  4

Met Ala Ala Thr Ala Gly Gly Gly Pro Gly Ala Ala Ala Gly Ala Val 
1               5                   10                  15      


Gly Ala Gly Gly Ala Ala Ala Ala Ser Gly Leu Ala Val Tyr Arg Arg 
            20                  25                  30          


Lys Asp Gly Gly Pro Ala Ser Lys Phe Trp Glu Ser Pro Asp Thr Val 
        35                  40                  45              


Ser Gln Leu Asp Ser Val Arg Val Trp Leu Gly Lys His Tyr Lys Lys 
    50                  55                  60                  


Tyr Val His Ala Asp Ala Pro Thr Asn Lys Thr Leu Ala Gly Leu Val 
65                  70                  75                  80  


Val Gln Leu Leu Gln Phe Gln Glu Asp Ala Phe Gly Lys His Val Thr 
                85                  90                  95      


Asn Pro Ala Phe Thr Lys Leu Pro Ala Lys Cys Phe Met Asp Phe Lys 
            100                 105                 110         


Ala Gly Gly Thr Leu Cys His Ile Leu Gly Ala Ala Tyr Lys Tyr Lys 
        115                 120                 125             


Asn Glu Gln Gly Trp Arg Arg Phe Asp Leu Gln Asn Pro Ser Arg Met 
    130                 135                 140                 


Asp Arg Asn Val Glu Met Phe Met Asn Ile Glu Lys Thr Leu Val Gln 
145                 150                 155                 160 


Asn Asn Cys Leu Thr Arg Pro Asn Ile Tyr Leu Ile Pro Asp Ile Asp 
                165                 170                 175     


Leu Lys Leu Ala Asn Lys Leu Lys Asp Ile Ile Lys Arg His Gln Gly 
            180                 185                 190         


Thr Phe Thr Asp Glu Lys Ser Lys Ala Ser His His Ile Tyr Pro Tyr 
        195                 200                 205             


Pro Ser Ser Gln Glu Asp Glu Glu Trp Leu Arg Pro Val Met Arg Arg 
    210                 215                 220                 


Asp Lys Gln Val Leu Val His Trp Gly Phe Tyr Pro Asp Ser Tyr Asp 
225                 230                 235                 240 


Thr Trp Val His Ser Asn Asp Val Asp Ala Glu Ile Glu Asp Ala Pro 
                245                 250                 255     


Ile Pro Glu Lys Pro Trp Lys Val His Val Lys Trp Ile Leu Asp Thr 
            260                 265                 270         


Asp Val Phe Asn Glu Trp Met Asn Glu Glu Asp Tyr Glu Val Asp Glu 
        275                 280                 285             


Asn Arg Lys Pro Val Ser Phe Arg Gln Arg Ile Ser Thr Lys Asn Glu 
    290                 295                 300                 


Glu Pro Val Arg Ser Pro Glu Arg Arg Asp Arg Lys Ala Ser Ala Asn 
305                 310                 315                 320 


Ser Arg Lys Arg Lys Pro Ser Pro Ser Pro Pro Pro Pro Thr Ala Thr 
                325                 330                 335     


Glu Ser Arg Lys Lys Ser Gly Lys Lys Gly Gln Ala Ser Leu Tyr Gly 
            340                 345                 350         


Lys Arg Arg Ser Gln Lys Glu Glu Asp Glu Gln Glu Asp Leu Thr Lys 
        355                 360                 365             


Asp Met Glu Asp Pro Thr Pro Val Pro Asn Ile Glu Glu Val Val Leu 
    370                 375                 380                 


Pro Lys Asn Val Asn Pro Lys Lys Asp Ser Glu Asn Thr Pro Val Lys 
385                 390                 395                 400 


Gly Gly Thr Val Ala Asp Leu Asp Glu Gln Asp Glu Glu Ala Val Thr 
                405                 410                 415     


Thr Gly Gly Lys Glu Asp Glu Asp Pro Ser Lys Gly Asp Pro Ser Arg 
            420                 425                 430         


Ser Val Asp Pro Gly Glu Asp Asn Val Thr Glu Gln Thr Asn His Ile 
        435                 440                 445             


Ile Ile Pro Ser Tyr Ala Ser Trp Phe Asp Tyr Asn Cys Ile His Val 
    450                 455                 460                 


Ile Glu Arg Arg Ala Leu Pro Glu Phe Phe Asn Gly Lys Asn Lys Ser 
465                 470                 475                 480 


Lys Thr Pro Glu Ile Tyr Leu Ala Tyr Arg Asn Phe Met Ile Asp Thr 
                485                 490                 495     


Tyr Arg Leu Asn Pro Gln Glu Tyr Leu Thr Ser Thr Ala Cys Arg Arg 
            500                 505                 510         


Asn Leu Thr Gly Asp Val Cys Ala Val Met Arg Val His Ala Phe Leu 
        515                 520                 525             


Glu Gln Trp Gly Leu Val Asn Tyr Gln Val Asp Pro Glu Ser Arg Pro 
    530                 535                 540                 


Met Ala Met Gly Pro Pro Pro Thr Pro His Phe Asn Val Leu Ala Asp 
545                 550                 555                 560 


Thr Pro Ser Gly Leu Val Pro Leu His Leu Arg Ser Pro Gln Val Pro 
                565                 570                 575     


Ala Ala Gln Gln Met Leu Asn Phe Pro Glu Lys Asn Lys Glu Lys Pro 
            580                 585                 590         


Ile Asp Leu Gln Asn Phe Gly Leu Arg Thr Asp Ile Tyr Ser Lys Lys 
        595                 600                 605             


Thr Leu Ala Lys Ser Lys Gly Ala Ser Ala Gly Arg Glu Trp Thr Glu 
    610                 615                 620                 


Gln Glu Thr Leu Leu Leu Leu Glu Ala Leu Glu Met Tyr Lys Asp Asp 
625                 630                 635                 640 


Trp Asn Lys Val Ser Glu His Val Gly Ser Arg Thr Gln Asp Glu Cys 
                645                 650                 655     


Ile Leu His Phe Leu Arg Leu Pro Ile Glu Asp Pro Tyr Leu Glu Asn 
            660                 665                 670         


Ser Asp Ala Ser Leu Gly Pro Leu Ala Tyr Gln Pro Val Pro Phe Ser 
        675                 680                 685             


Gln Ser Gly Asn Pro Val Met Ser Thr Val Ala Phe Leu Ala Ser Val 
    690                 695                 700                 


Val Asp Pro Arg Val Ala Ser Ala Ala Ala Lys Ala Ala Leu Glu Glu 
705                 710                 715                 720 


Phe Ser Arg Val Arg Glu Glu Val Pro Leu Glu Leu Val Glu Ala His 
                725                 730                 735     


Val Lys Lys Val Gln Glu Ala Ala Arg Ala Ser Gly Lys Val Asp Pro 
            740                 745                 750         


Thr Tyr Gly Leu Glu Ser Ser Cys Ile Ala Gly Thr Gly Pro Asp Glu 
        755                 760                 765             


Pro Glu Lys Leu Glu Gly Ser Glu Glu Glu Lys Met Glu Thr Asp Pro 
    770                 775                 780                 


Asp Gly Gln Gln Pro Glu Lys Ala Glu Asn Lys Val Glu Asn Glu Ser 
785                 790                 795                 800 


Asp Glu Gly Asp Lys Ile Gln Asp Arg Glu Asn Glu Lys Asn Thr Glu 
                805                 810                 815     


Lys Glu Gln Asp Ser Asp Val Ser Glu Asp Val Lys Pro Glu Glu Lys 
            820                 825                 830         


Glu Asn Glu Glu Asn Lys Glu Leu Thr Asp Thr Cys Lys Glu Arg Glu 
        835                 840                 845             


Ser Asp Ala Gly Lys Lys Lys Val Glu His Glu Ile Ser Glu Gly Asn 
    850                 855                 860                 


Val Ala Thr Ala Ala Ala Ala Ala Leu Ala Ser Ala Ala Thr Lys Ala 
865                 870                 875                 880 


Lys His Leu Ala Ala Val Glu Glu Arg Lys Ile Lys Ser Leu Val Ala 
                885                 890                 895     


Leu Leu Val Glu Thr Gln Met Lys Lys Leu Glu Ile Lys Leu Arg His 
            900                 905                 910         


Phe Glu Glu Leu Glu Thr Ile Met Asp Arg Glu Lys Glu Ala Leu Glu 
        915                 920                 925             


Gln Gln Arg Gln Gln Leu Leu Thr Glu Arg Gln Asn Phe His Met Glu 
    930                 935                 940                 


Gln Leu Lys Tyr Ala Glu Leu Arg Ala Arg Gln Gln Met Glu Gln Gln 
945                 950                 955                 960 


Gln Gln His Gly Gln Thr Pro Gln Gln Ala His Gln His Thr Gly Gly 
                965                 970                 975     


Pro Gly Met Ala Pro Leu Gly Ala Thr Gly His Pro Gly Met Met Pro 
            980                 985                 990         


His Gln Gln Pro Pro Pro Tyr Pro  Leu Met His His Gln  Met Pro Pro 
        995                 1000                 1005             


Pro His  Pro Pro Gln Pro Gly  Gln Ile Pro Gly Pro  Gly Ser Met 
    1010                 1015                 1020             


Met Pro  Gly Gln Pro Met Pro  Gly Arg Met Ile Pro  Ala Val Ala 
    1025                 1030                 1035             


Ala Asn  Ile His Pro Thr Gly  Ser Gly Pro Thr Pro  Pro Gly Met 
    1040                 1045                 1050             


Pro Pro  Met Pro Gly Asn Ile  Leu Gly Pro Arg Val  Pro Leu Thr 
    1055                 1060                 1065             


Ala Pro  Asn Gly Met Tyr Pro  Pro Pro Pro Gln Gln  Gln Gln Pro 
    1070                 1075                 1080             


Pro Pro  Pro Ala Asp Gly Val  Pro Pro Pro Pro Ala  Pro Gly Pro 
    1085                 1090                 1095             


Pro Ala  Ser Ala Thr Pro 
    1100                 


<210>  5
<211>  3431
<212>  DNA
<213>  Homo sapiens

<400>  5
agcacgcctt ttccgctagt cgccccgctc tatcccatag tctcgctgcc ctgagcctcc       60

cgtgccggcc ggccggccgg gggaacaggc gggcgctcgg ggggcgctcg gggggcgggg      120

ggagttccgg ttccggttct ttgtgcggct gcatcggcgg ctccgggaag atggcggccc      180

gggcgggttt ccagtctgtg gctccaagcg gcggcgccgg agcctcagga ggggcgggcg      240

cggctgctgc cttgggcccg ggcggaactc cggggcctcc tgtgcgaatg ggcccggctc      300

cgggtcaagg gctgtaccgc tccccgatgc ccggagcggc ctatccgaga ccaggtatgt      360

tgccaggcag ccgaatgaca cctcagggac cttccatggg accccctggc tatgggggga      420

acccttcagt ccgacctggc ctggcccagt cagggatgga tcagtcccgc aagagacctg      480

cccctcagca gatccagcag gtccagcagc aggcggtcca aaatcgaaac cacaatgcaa      540

agaaaaagaa gatggctgac aaaattctac ctcaaaggat tcgtgaactg gtaccagaat      600

cccaggccta tatggatctc ttggcttttg aaaggaaact ggaccagact atcatgagga      660

aacggctaga tatccaagag gccttgaaac gtcccatcaa gcaaaaacgg aagctgcgaa      720

ttttcatttc taacactttc aatccggcta agtcagatgc cgaggatggg gaagggacgg      780

tggcttcctg ggagcttcgg gtagaaggac ggctcctgga ggattcagcc ttgtccaaat      840

atgatgccac taaacaaaag aggaagttct cttccttttt taagtccttg gtgattgaac      900

tggacaaaga cctgtatggg ccagacaacc atctggtaga atggcacagg accgccacta      960

cccaggagac cgatggcttt caggtgaagc ggccgggaga cgtgaatgta cggtgtactg     1020

tcctactgat gctggattac cagcctcccc agtttaaatt agacccccgc ctagctcgac     1080

tcctgggcat ccatacccag actcgtccag tgatcatcca agcactgtgg caatatatta     1140

agacacataa gctccaggac cctcacgagc gggagtttgt catctgtgac aagtacctgc     1200

agcagatctt tgagtctcaa cgtatgaagt tttcagagat ccctcagcgg ctccatgcct     1260

tgcttatgcc accagaacct atcatcatta atcatgtcat cagtgttgac ccgaatgatc     1320

agaaaaagac agcttgttat gacattgatg ttgaagtgga tgacaccttg aagacccaga     1380

tgaattcttt tctgctgtcc actgccagcc aacaggagat tgctactcta gacaacaaga     1440

tccatgagac aatagaaacc atcaaccagc tgaagactca gcgggagttc atgctgagct     1500

ttgccagaga ccctcagggt ttcatcaatg actggcttca gtcccagtgc agggacctca     1560

agacaatgac tgatgtggtg ggtaacccag aggaggagcg ccgagctgag ttctacttcc     1620

agccctgggc tcaggaggct gtgtgccgat acttctactc caaggtgcag cagagacgac     1680

aagaattaga gcaagccctg ggaatccgga atacataggg cctctcccac agccctgatt     1740

cgactgcacc aattcttgat ttgggccctg tgctgcctgc ctcatagtat ctgccttggt     1800

cttgcttggg gcgttccagg ggatgctgtt ggttcaagga caacaccaga atgaagaggg     1860

tctcacaaga cacctgttat cctcttcttt caccctatct cttcccaccc ccagcttccc     1920

tttgccccac aaagttccca tgtgcctgta ccctcccctg gtctacatag gacctctaga     1980

tagtgttaga gagagaacat gtagtggtaa tgagtgcttg gaatggattg ggcctcaggc     2040

caggtggtct tcaaggggac cagctaactg atcctgccct tcagagaccc aggagttggg     2100

agctttcgct ccttctccaa gactcaggcc tgtgggcact ctataagcta gttgatcttg     2160

gctctcctga taacagaatc caatttcctt ccttccctcc acaggtttgg aacaaactct     2220

cccttcactt gttgccctgt agcactacag aaaccctggt tcttgggctc cactgagccc     2280

caggtcagtc cccagccctc tgggttggcc tgctgtcagt gcttctctca ctccttagtt     2340

ggggtccaca tcagtattgg agttttgttc tttattgctc cctcccagac actccctgtg     2400

gctgcccttt gtgattccct cagatctgcc ctaatcccgg gcatttgggt gggggaatct     2460

tgcctttccc tttcagagcc ccagggatct catctgggga actgtcattg ccagcagagg     2520

ctgttccttc ctgctgtttg gagatgtgac tcattcattc actcactcca ccctgcctct     2580

gcatccctta atggagaaac gggcctaaaa ccaaacgggt aaaaagccct gggccatccc     2640

tgtcttcctg tcccttgtct gcccagttga cacctactgg tgacttctag ggcactgagg     2700

agtgaaagcg cctagggctg gagaatagcg ctgagttggg tttgtgactc ttccctctcc     2760

ctgcctcaca ggattgtgac tccccagccc ctgccctcaa agcttcagac ccctcaggta     2820

gcagcaggac cttgtgatct tggccccttg gatctgagat ggtttttgca tctttccagg     2880

agagcctcac attcttcttc caggttgtat cacccccgag ttagcatatc ccaggctcgc     2940

agactcaaca cagcaagggt gggagacagc tgggcacaaa gggggaattc cgttcagcat     3000

gggctctaaa cccacagaac tgacaaagcc cctgcttccc caccccctcc tcaggctcct     3060

gcgagcacac ccccaccccc aaatccctcc ctgttctaca ctggggacag cagaattttc     3120

tccccgtctt ccccttcctg ccattttccc tcccttgaaa ggttgacact ggacaacctt     3180

ggggcagctg agccctggcc gcctcctggc tggaaccatg agaaggaagc tcagtacttc     3240

ccacagtgtc cctgttgata actgttttta ttaactgaat tgtttttttc atggaccaaa     3300

cttttttttg tactgtcccc ttattgatgt tacccagttt taataaaaga atcttctgaa     3360

ggatgggtcc tcctacctac tgtgagagag ctcttccctg agctcttctt ccttcaatac     3420

cattagccaa a                                                          3431


<210>  6
<211>  515
<212>  PRT
<213>  Homo sapiens

<400>  6

Met Ala Ala Arg Ala Gly Phe Gln Ser Val Ala Pro Ser Gly Gly Ala 
1               5                   10                  15      


Gly Ala Ser Gly Gly Ala Gly Ala Ala Ala Ala Leu Gly Pro Gly Gly 
            20                  25                  30          


Thr Pro Gly Pro Pro Val Arg Met Gly Pro Ala Pro Gly Gln Gly Leu 
        35                  40                  45              


Tyr Arg Ser Pro Met Pro Gly Ala Ala Tyr Pro Arg Pro Gly Met Leu 
    50                  55                  60                  


Pro Gly Ser Arg Met Thr Pro Gln Gly Pro Ser Met Gly Pro Pro Gly 
65                  70                  75                  80  


Tyr Gly Gly Asn Pro Ser Val Arg Pro Gly Leu Ala Gln Ser Gly Met 
                85                  90                  95      


Asp Gln Ser Arg Lys Arg Pro Ala Pro Gln Gln Ile Gln Gln Val Gln 
            100                 105                 110         


Gln Gln Ala Val Gln Asn Arg Asn His Asn Ala Lys Lys Lys Lys Met 
        115                 120                 125             


Ala Asp Lys Ile Leu Pro Gln Arg Ile Arg Glu Leu Val Pro Glu Ser 
    130                 135                 140                 


Gln Ala Tyr Met Asp Leu Leu Ala Phe Glu Arg Lys Leu Asp Gln Thr 
145                 150                 155                 160 


Ile Met Arg Lys Arg Leu Asp Ile Gln Glu Ala Leu Lys Arg Pro Ile 
                165                 170                 175     


Lys Gln Lys Arg Lys Leu Arg Ile Phe Ile Ser Asn Thr Phe Asn Pro 
            180                 185                 190         


Ala Lys Ser Asp Ala Glu Asp Gly Glu Gly Thr Val Ala Ser Trp Glu 
        195                 200                 205             


Leu Arg Val Glu Gly Arg Leu Leu Glu Asp Ser Ala Leu Ser Lys Tyr 
    210                 215                 220                 


Asp Ala Thr Lys Gln Lys Arg Lys Phe Ser Ser Phe Phe Lys Ser Leu 
225                 230                 235                 240 


Val Ile Glu Leu Asp Lys Asp Leu Tyr Gly Pro Asp Asn His Leu Val 
                245                 250                 255     


Glu Trp His Arg Thr Ala Thr Thr Gln Glu Thr Asp Gly Phe Gln Val 
            260                 265                 270         


Lys Arg Pro Gly Asp Val Asn Val Arg Cys Thr Val Leu Leu Met Leu 
        275                 280                 285             


Asp Tyr Gln Pro Pro Gln Phe Lys Leu Asp Pro Arg Leu Ala Arg Leu 
    290                 295                 300                 


Leu Gly Ile His Thr Gln Thr Arg Pro Val Ile Ile Gln Ala Leu Trp 
305                 310                 315                 320 


Gln Tyr Ile Lys Thr His Lys Leu Gln Asp Pro His Glu Arg Glu Phe 
                325                 330                 335     


Val Ile Cys Asp Lys Tyr Leu Gln Gln Ile Phe Glu Ser Gln Arg Met 
            340                 345                 350         


Lys Phe Ser Glu Ile Pro Gln Arg Leu His Ala Leu Leu Met Pro Pro 
        355                 360                 365             


Glu Pro Ile Ile Ile Asn His Val Ile Ser Val Asp Pro Asn Asp Gln 
    370                 375                 380                 


Lys Lys Thr Ala Cys Tyr Asp Ile Asp Val Glu Val Asp Asp Thr Leu 
385                 390                 395                 400 


Lys Thr Gln Met Asn Ser Phe Leu Leu Ser Thr Ala Ser Gln Gln Glu 
                405                 410                 415     


Ile Ala Thr Leu Asp Asn Lys Ile His Glu Thr Ile Glu Thr Ile Asn 
            420                 425                 430         


Gln Leu Lys Thr Gln Arg Glu Phe Met Leu Ser Phe Ala Arg Asp Pro 
        435                 440                 445             


Gln Gly Phe Ile Asn Asp Trp Leu Gln Ser Gln Cys Arg Asp Leu Lys 
    450                 455                 460                 


Thr Met Thr Asp Val Val Gly Asn Pro Glu Glu Glu Arg Arg Ala Glu 
465                 470                 475                 480 


Phe Tyr Phe Gln Pro Trp Ala Gln Glu Ala Val Cys Arg Tyr Phe Tyr 
                485                 490                 495     


Ser Lys Val Gln Gln Arg Arg Gln Glu Leu Glu Gln Ala Leu Gly Ile 
            500                 505                 510         


Arg Asn Thr 
        515 


<210>  7
<211>  3308
<212>  DNA
<213>  Homo sapiens

<400>  7
agcacgcctt ttccgctagt cgccccgctc tatcccatag tctcgctgcc ctgagcctcc       60

cgtgccggcc ggccggccgg gggaacaggc gggcgctcgg ggggcgctcg gggggcgggg      120

ggagttccgg ttccggttct ttgtgcggct gcatcggcgg ctccgggaag atggcggccc      180

gggcgggttt ccagtctgtg gctccaagcg gcggcgccgg agcctcagga ggggcgggcg      240

cggctgctgc cttgggcccg ggcggaactc cggggcctcc tgtgcgaatg ggcccggctc      300

cgggtcaagg gctgtaccgc tccccgatgc ccggagcggc ctatccgaga ccaggtatgt      360

tgccaggcag ccgaatgaca cctcagggac cttccatggg accccctggc tatgggggga      420

acccttcagt ccgacctggc ctggcccagt cagggatgga tcagtcccgc aagagacctg      480

cccctcagca gatccagcag gtccagcagc aggcggtcca aaatcgaaac cacaatgcaa      540

agaaaaagaa gatggctgac aaaattctac ctcaaaggat tcgtgaactg gtaccagaat      600

cccaggccta tatggatctc ttggcttttg aaaggaaact ggaccagact atcatgagga      660

aacggctaga tatccaagag gccttgaaac gtcccatcaa gcaaaaacgg aagctgcgaa      720

ttttcatttc taacactttc aatccggcta agtcagatgc cgaggatggg gaagggacgg      780

tggcttcctg ggagcttcgg gtagaaggac ggctcctgga ggattcagcc ttgtccaaat      840

atgatgccac taaacaaaag aggaagttct cttccttttt taagtccttg gtgattgaac      900

tggacaaaga cctgtatggg ccagacaacc atctggtaga atggcacagg accgccacta      960

cccaggagac cgatggcttt caggtgaagc ggccgggaga cgtgaatgta cggtgtactg     1020

tcctactgat gctggattac cagcctcccc agtttaaatt agacccccgc ctagctcgac     1080

tcctgggcat ccatacccag actcgtccag tgatcatcca agcactgtgg caatatatta     1140

agacacataa gctccaggac cctcacgagc gggagtttgt catctgtgac aagtacctgc     1200

agcagatctt tgagtctcaa cgtatgaagt tttcagagat ccctcagcgg ctccatgcct     1260

tgcttatgcc accagaacct atcatcatta atcatgtcat cagtgttgac ccgaatgatc     1320

agaaaaagac agcttgttat gacattgatg ttgaagtgga tgacaccttg aagacccaga     1380

tgaattcttt tctgctgtcc actgccagcc aacaggagat tgctactcta gacaacaaga     1440

caatgactga tgtggtgggt aacccagagg aggagcgccg agctgagttc tacttccagc     1500

cctgggctca ggaggctgtg tgccgatact tctactccaa ggtgcagcag agacgacaag     1560

aattagagca agccctggga atccggaata catagggcct ctcccacagc cctgattcga     1620

ctgcaccaat tcttgatttg ggccctgtgc tgcctgcctc atagtatctg ccttggtctt     1680

gcttggggcg ttccagggga tgctgttggt tcaaggacaa caccagaatg aagagggtct     1740

cacaagacac ctgttatcct cttctttcac cctatctctt cccaccccca gcttcccttt     1800

gccccacaaa gttcccatgt gcctgtaccc tcccctggtc tacataggac ctctagatag     1860

tgttagagag agaacatgta gtggtaatga gtgcttggaa tggattgggc ctcaggccag     1920

gtggtcttca aggggaccag ctaactgatc ctgcccttca gagacccagg agttgggagc     1980

tttcgctcct tctccaagac tcaggcctgt gggcactcta taagctagtt gatcttggct     2040

ctcctgataa cagaatccaa tttccttcct tccctccaca ggtttggaac aaactctccc     2100

ttcacttgtt gccctgtagc actacagaaa ccctggttct tgggctccac tgagccccag     2160

gtcagtcccc agccctctgg gttggcctgc tgtcagtgct tctctcactc cttagttggg     2220

gtccacatca gtattggagt tttgttcttt attgctccct cccagacact ccctgtggct     2280

gccctttgtg attccctcag atctgcccta atcccgggca tttgggtggg ggaatcttgc     2340

ctttcccttt cagagcccca gggatctcat ctggggaact gtcattgcca gcagaggctg     2400

ttccttcctg ctgtttggag atgtgactca ttcattcact cactccaccc tgcctctgca     2460

tcccttaatg gagaaacggg cctaaaacca aacgggtaaa aagccctggg ccatccctgt     2520

cttcctgtcc cttgtctgcc cagttgacac ctactggtga cttctagggc actgaggagt     2580

gaaagcgcct agggctggag aatagcgctg agttgggttt gtgactcttc cctctccctg     2640

cctcacagga ttgtgactcc ccagcccctg ccctcaaagc ttcagacccc tcaggtagca     2700

gcaggacctt gtgatcttgg ccccttggat ctgagatggt ttttgcatct ttccaggaga     2760

gcctcacatt cttcttccag gttgtatcac ccccgagtta gcatatccca ggctcgcaga     2820

ctcaacacag caagggtggg agacagctgg gcacaaaggg ggaattccgt tcagcatggg     2880

ctctaaaccc acagaactga caaagcccct gcttccccac cccctcctca ggctcctgcg     2940

agcacacccc cacccccaaa tccctccctg ttctacactg gggacagcag aattttctcc     3000

ccgtcttccc cttcctgcca ttttccctcc cttgaaaggt tgacactgga caaccttggg     3060

gcagctgagc cctggccgcc tcctggctgg aaccatgaga aggaagctca gtacttccca     3120

cagtgtccct gttgataact gtttttatta actgaattgt ttttttcatg gaccaaactt     3180

ttttttgtac tgtcccctta ttgatgttac ccagttttaa taaaagaatc ttctgaagga     3240

tgggtcctcc tacctactgt gagagagctc ttccctgagc tcttcttcct tcaataccat     3300

tagccaaa                                                              3308


<210>  8
<211>  474
<212>  PRT
<213>  Homo sapiens

<400>  8

Met Ala Ala Arg Ala Gly Phe Gln Ser Val Ala Pro Ser Gly Gly Ala 
1               5                   10                  15      


Gly Ala Ser Gly Gly Ala Gly Ala Ala Ala Ala Leu Gly Pro Gly Gly 
            20                  25                  30          


Thr Pro Gly Pro Pro Val Arg Met Gly Pro Ala Pro Gly Gln Gly Leu 
        35                  40                  45              


Tyr Arg Ser Pro Met Pro Gly Ala Ala Tyr Pro Arg Pro Gly Met Leu 
    50                  55                  60                  


Pro Gly Ser Arg Met Thr Pro Gln Gly Pro Ser Met Gly Pro Pro Gly 
65                  70                  75                  80  


Tyr Gly Gly Asn Pro Ser Val Arg Pro Gly Leu Ala Gln Ser Gly Met 
                85                  90                  95      


Asp Gln Ser Arg Lys Arg Pro Ala Pro Gln Gln Ile Gln Gln Val Gln 
            100                 105                 110         


Gln Gln Ala Val Gln Asn Arg Asn His Asn Ala Lys Lys Lys Lys Met 
        115                 120                 125             


Ala Asp Lys Ile Leu Pro Gln Arg Ile Arg Glu Leu Val Pro Glu Ser 
    130                 135                 140                 


Gln Ala Tyr Met Asp Leu Leu Ala Phe Glu Arg Lys Leu Asp Gln Thr 
145                 150                 155                 160 


Ile Met Arg Lys Arg Leu Asp Ile Gln Glu Ala Leu Lys Arg Pro Ile 
                165                 170                 175     


Lys Gln Lys Arg Lys Leu Arg Ile Phe Ile Ser Asn Thr Phe Asn Pro 
            180                 185                 190         


Ala Lys Ser Asp Ala Glu Asp Gly Glu Gly Thr Val Ala Ser Trp Glu 
        195                 200                 205             


Leu Arg Val Glu Gly Arg Leu Leu Glu Asp Ser Ala Leu Ser Lys Tyr 
    210                 215                 220                 


Asp Ala Thr Lys Gln Lys Arg Lys Phe Ser Ser Phe Phe Lys Ser Leu 
225                 230                 235                 240 


Val Ile Glu Leu Asp Lys Asp Leu Tyr Gly Pro Asp Asn His Leu Val 
                245                 250                 255     


Glu Trp His Arg Thr Ala Thr Thr Gln Glu Thr Asp Gly Phe Gln Val 
            260                 265                 270         


Lys Arg Pro Gly Asp Val Asn Val Arg Cys Thr Val Leu Leu Met Leu 
        275                 280                 285             


Asp Tyr Gln Pro Pro Gln Phe Lys Leu Asp Pro Arg Leu Ala Arg Leu 
    290                 295                 300                 


Leu Gly Ile His Thr Gln Thr Arg Pro Val Ile Ile Gln Ala Leu Trp 
305                 310                 315                 320 


Gln Tyr Ile Lys Thr His Lys Leu Gln Asp Pro His Glu Arg Glu Phe 
                325                 330                 335     


Val Ile Cys Asp Lys Tyr Leu Gln Gln Ile Phe Glu Ser Gln Arg Met 
            340                 345                 350         


Lys Phe Ser Glu Ile Pro Gln Arg Leu His Ala Leu Leu Met Pro Pro 
        355                 360                 365             


Glu Pro Ile Ile Ile Asn His Val Ile Ser Val Asp Pro Asn Asp Gln 
    370                 375                 380                 


Lys Lys Thr Ala Cys Tyr Asp Ile Asp Val Glu Val Asp Asp Thr Leu 
385                 390                 395                 400 


Lys Thr Gln Met Asn Ser Phe Leu Leu Ser Thr Ala Ser Gln Gln Glu 
                405                 410                 415     


Ile Ala Thr Leu Asp Asn Lys Thr Met Thr Asp Val Val Gly Asn Pro 
            420                 425                 430         


Glu Glu Glu Arg Arg Ala Glu Phe Tyr Phe Gln Pro Trp Ala Gln Glu 
        435                 440                 445             


Ala Val Cys Arg Tyr Phe Tyr Ser Lys Val Gln Gln Arg Arg Gln Glu 
    450                 455                 460                 


Leu Glu Gln Ala Leu Gly Ile Arg Asn Thr 
465                 470                 


<210>  9
<211>  3153
<212>  DNA
<213>  Mus musculus

<400>  9
gttctttgtg cagctgcagc ggcggctccg ggaagatggc ggcccgggcg ggtttccagt       60

ctgtggctcc gagcggcggc gcgggagcct caggaggagc gggcgtggcg gctgctctgg      120

gcccgggcgg aactcccggg cctcccgtgc gaatgggccc ggcgccgggt caagggctgt      180

accgctctcc gatgcccggg gcggcctatc cgagaccagg tatgctgcca ggtagccgaa      240

tgacacctca gggaccttcc atgggacctc ctggctatgg ggggaaccct tcagtccgac      300

ctggtctggc ccagtcaggg atggaccagt cccgcaagag acctgcacct caacagatcc      360

agcaggtcca gcagcaggcg gtccaaaatc gaaatcacaa tgcaaagaaa aagaagatgg      420

ctgacaaaat cctacctcaa aggattcggg aactggtccc agaatcacag gcctacatgg      480

atctcctggc ttttgaaagg aaactggacc agactattat gaggaagcgg ctagatatcc      540

aggaggcctt gaaacgtccc atcaagcaaa aacggaagct gcgaattttc atttctaaca      600

cgttcaatcc ggctaagtcg gacgcggagg atggggaagg gacggtggct tcctgggagc      660

tccgggtaga aggccggctc ctggaggacg cggccttgtc caaatatgac gccaccaagc      720

aaaagagaaa gttctcttcc ttttttaagt ccttggtgat cgaactggac aaagacctct      780

atggcccaga caaccatctg gtagaatggc acaggaccgc cactacccag gagaccgatg      840

gcttccaggt gaagcggcca ggagatgtga atgtacggtg tactgtcctg ctgatgctgg      900

actaccagcc cccccagttt aaattagacc ctcgcctggc tcggctcttg ggcatccata      960

cccagacacg tccagtgatc atccaagcac tgtggcagta tattaaaaca cacaagctcc     1020

aggaccctca cgagcgagag tttgttctct gtgacaagta cctccagcag atctttgaat     1080

ctcagcggat gaagttctca gagatccctc agcggctcca cgccttgctt atgccaccag     1140

agcccatcat catcaatcat gtcatcagtg tggacccaaa tgaccagaaa aagaccgcgt     1200

gctatgacat tgacgtggag gtggatgaca ctctgaagac ccagatgaac tctttcctgt     1260

tgtccactgc cagccagcag gagatcgcca ctctagacaa caagatccat gagacgatag     1320

agaccatcaa ccagctgaag acccagcgag agttcatgtt gagctttgcc cgagaccctc     1380

agggtttcat caatgattgg cttcagtccc agtgcaggga cctcaagacg atgactgatg     1440

tggtgggtaa cccggaagag gagcgtcgtg ctgagttcta cttccagccc tgggctcagg     1500

aggctgtgtg ccgatacttc tactccaagg tgcagcagag gcggcaagag ttagagcaag     1560

ccctgggaat ccgaaacaca tagggcctct gtggccctag cctggctgca ccgattcctt     1620

gggccctgtg ctgcctgcct cagtgtacct gtcttggtct tgcttgaggc attccagggg     1680

acttggcttc aggacagtgt cacaatgaag agggtgtcac atttctgtct cacagtcacc     1740

tgttatcccg tcctgtaccc cagtcgtccc ccgtcccgtc gtgtcccccc ctcaccccac     1800

cccgcctcag ctcctcccca tcaggctcct gtgtgcctct acctccctat cctacatagg     1860

acctctagat agtgttagag aaccacagag tgggggcctc ctgaggtcag gtggtcttga     1920

gggagaccag ctacactgat cctgcccttg tcaggagacc taggccttgg gagctatccc     1980

tgtctgagcc tcaggcctag ggcagtctgt aagctagctg accttggccc tcccggtagc     2040

ttgacttctt ccctcccctc cgcaggttgg ggcagaggct cctttacctc tggcagtaaa     2100

ggagcctggg cttcactgag ccccgggttg gtcccctgcc ctctggactt aacctgctgt     2160

ctcagtgtcc tctgacccct taggggtcca tgtcagtatt ggagtgtgtg ttgaattgtt     2220

gctccctccc acacactccc gtagccgccc agtttaggat ttccctacac ctgccctaac     2280

ccacgctttt gggttgggga tcttgccttt ccttgtcatt cccagcagag actgttcctt     2340

cctgctgtta gaggagtggc ttgtttattc actccaccct gccccctcct gtaaatggag     2400

aaacaggcct gaaatcaaac gggtaaagcc ctaggccatc cctgtcttcc tgtcccatgt     2460

ctgcccagtt gaatcccact ggtggcttcc cgggcactga ggagtaaaag cgcctagggc     2520

tggagaatag gtctgaaatg ggtttgtgac tccccacccc ctgccctgcc ctcaaagctt     2580

cagacccctc agggagcagc aggatgtggg atcgaggccc cttgggacag atgctttgaa     2640

tcttccaggg aagcctccga ttcttccagg tttgtcaccc ggagttagca tgtcccaggc     2700

tcgcagacaa cactgcaggg tgggagacag ctgggcacag ggggattctg ttgagcatgg     2760

gctctgaacc cacagaactg acaaagcccc tgcttcccca cccccacctc aggctcctgc     2820

gagcagtgct cctgcaccct tcccagcctg ttctgtactg gggacagcag tcttctccct     2880

gtcctcccat gtcctatatc cacccctccc cttggaaggt cctccccaca gtgacactgg     2940

acagccctgg ggcagctgag ccccagcctg gcttctggct ggaagcgcga tgaggagact     3000

tagcactcca cagtgtccct ggtggtaact gttcttatta actgattgtg ttttgttttg     3060

ttttgttttg ttttcatgga ccaaaatttt ttttgtactg tctccttaac tgatgtcacc     3120

cagttttaat aaaagacttc taaagagcag gtc                                  3153


<210>  10
<211>  515
<212>  PRT
<213>  Mus musculus

<400>  10

Met Ala Ala Arg Ala Gly Phe Gln Ser Val Ala Pro Ser Gly Gly Ala 
1               5                   10                  15      


Gly Ala Ser Gly Gly Ala Gly Val Ala Ala Ala Leu Gly Pro Gly Gly 
            20                  25                  30          


Thr Pro Gly Pro Pro Val Arg Met Gly Pro Ala Pro Gly Gln Gly Leu 
        35                  40                  45              


Tyr Arg Ser Pro Met Pro Gly Ala Ala Tyr Pro Arg Pro Gly Met Leu 
    50                  55                  60                  


Pro Gly Ser Arg Met Thr Pro Gln Gly Pro Ser Met Gly Pro Pro Gly 
65                  70                  75                  80  


Tyr Gly Gly Asn Pro Ser Val Arg Pro Gly Leu Ala Gln Ser Gly Met 
                85                  90                  95      


Asp Gln Ser Arg Lys Arg Pro Ala Pro Gln Gln Ile Gln Gln Val Gln 
            100                 105                 110         


Gln Gln Ala Val Gln Asn Arg Asn His Asn Ala Lys Lys Lys Lys Met 
        115                 120                 125             


Ala Asp Lys Ile Leu Pro Gln Arg Ile Arg Glu Leu Val Pro Glu Ser 
    130                 135                 140                 


Gln Ala Tyr Met Asp Leu Leu Ala Phe Glu Arg Lys Leu Asp Gln Thr 
145                 150                 155                 160 


Ile Met Arg Lys Arg Leu Asp Ile Gln Glu Ala Leu Lys Arg Pro Ile 
                165                 170                 175     


Lys Gln Lys Arg Lys Leu Arg Ile Phe Ile Ser Asn Thr Phe Asn Pro 
            180                 185                 190         


Ala Lys Ser Asp Ala Glu Asp Gly Glu Gly Thr Val Ala Ser Trp Glu 
        195                 200                 205             


Leu Arg Val Glu Gly Arg Leu Leu Glu Asp Ala Ala Leu Ser Lys Tyr 
    210                 215                 220                 


Asp Ala Thr Lys Gln Lys Arg Lys Phe Ser Ser Phe Phe Lys Ser Leu 
225                 230                 235                 240 


Val Ile Glu Leu Asp Lys Asp Leu Tyr Gly Pro Asp Asn His Leu Val 
                245                 250                 255     


Glu Trp His Arg Thr Ala Thr Thr Gln Glu Thr Asp Gly Phe Gln Val 
            260                 265                 270         


Lys Arg Pro Gly Asp Val Asn Val Arg Cys Thr Val Leu Leu Met Leu 
        275                 280                 285             


Asp Tyr Gln Pro Pro Gln Phe Lys Leu Asp Pro Arg Leu Ala Arg Leu 
    290                 295                 300                 


Leu Gly Ile His Thr Gln Thr Arg Pro Val Ile Ile Gln Ala Leu Trp 
305                 310                 315                 320 


Gln Tyr Ile Lys Thr His Lys Leu Gln Asp Pro His Glu Arg Glu Phe 
                325                 330                 335     


Val Leu Cys Asp Lys Tyr Leu Gln Gln Ile Phe Glu Ser Gln Arg Met 
            340                 345                 350         


Lys Phe Ser Glu Ile Pro Gln Arg Leu His Ala Leu Leu Met Pro Pro 
        355                 360                 365             


Glu Pro Ile Ile Ile Asn His Val Ile Ser Val Asp Pro Asn Asp Gln 
    370                 375                 380                 


Lys Lys Thr Ala Cys Tyr Asp Ile Asp Val Glu Val Asp Asp Thr Leu 
385                 390                 395                 400 


Lys Thr Gln Met Asn Ser Phe Leu Leu Ser Thr Ala Ser Gln Gln Glu 
                405                 410                 415     


Ile Ala Thr Leu Asp Asn Lys Ile His Glu Thr Ile Glu Thr Ile Asn 
            420                 425                 430         


Gln Leu Lys Thr Gln Arg Glu Phe Met Leu Ser Phe Ala Arg Asp Pro 
        435                 440                 445             


Gln Gly Phe Ile Asn Asp Trp Leu Gln Ser Gln Cys Arg Asp Leu Lys 
    450                 455                 460                 


Thr Met Thr Asp Val Val Gly Asn Pro Glu Glu Glu Arg Arg Ala Glu 
465                 470                 475                 480 


Phe Tyr Phe Gln Pro Trp Ala Gln Glu Ala Val Cys Arg Tyr Phe Tyr 
                485                 490                 495     


Ser Lys Val Gln Gln Arg Arg Gln Glu Leu Glu Gln Ala Leu Gly Ile 
            500                 505                 510         


Arg Asn Thr 
        515 


<210>  11
<211>  5741
<212>  DNA
<213>  Homo sapiens

<400>  11
gcgcggccag agcggccggg gacaggctcc gaggcaggcc cgacccgcct ccccggcgcc       60

gccgtggctc gacggagacc agctaggctg gcccccaaga ggaccctttc caagtcccca      120

gctgggggcc ctgtgtagac ctggagtgga cacgcccctc cttcccttca tgattcgttt      180

gtagcgcagt ggcgatggat gatgaggatg ggagatgctt actagacgtg atttgtgacc      240

cacaggccct caatgacttc ttgcatggat ccgagaagct tgacagtgat gacctcctgg      300

ataatcccgg ggaggcccaa agtgccttct atgaaggtcc tgggctccat gtgcaagaag      360

cttccggcaa ccacctgaac ccagagccca accagccggc ccccagtgtg gacctagact      420

tcctggaaga tgacatcctg ggctctcctg cgacaggggg cggcggcggg ggcagtgggg      480

gcgctgacca gccctgtgac atcctccagc agagcctcca agaggccaac atcacggagc      540

agacgctgga ggccgaggct gagctggacc tgggtccctt ccagctgccc accctgcagc      600

ctgcggatgg cggggcaggc ccgacgggcg ctggaggggc agcggccgtg gctgcggggc      660

cccaagccct cttcccaggc agcaccgacc tgctggggct gcagggcccg cctaccgtgc      720

tgacccacca ggccctggtg ccgccccagg acgtggtcaa caaggccctg agtgtgcagc      780

ccttcctgca gcctgtgggc ctgggcaatg tgacactgca gcccatcccg ggcctccaag      840

gcctgcccaa tggcagccct gggggtgcca cggcggccac actgggcctg gcgcccatcc      900

aggtggtggg ccagcccgtc atggcgctca acacgcccac ctcccagctc ctggccaagc      960

aggtgcccgt cagcggctac ctggcctcgg cggctggccc ctcggagccc gtgacgctgg     1020

cgtcggccgg tgtctcgcca cagggggctg gcctggtcat ccagaagaac ctctcggccg     1080

ctgtggccac cacgctcaat gggaactctg tgttcggagg cgcgggggcc gcctcggctc     1140

ccaccgggac gccctcggga cagccgctgg cggtggcccc aggcctcggc tcgtcgccac     1200

tggtcccggc gcccaacgtg atcctgcatc gcacacccac gcccatccag cccaagcccg     1260

cgggggtgct gccgcccaag ctctaccagc tgacgcccaa gccgtttgcg cccgcgggcg     1320

ccacgctcac catccagggc gagccggggg cgctcccgca gcagcccaag gccccgcaga     1380

acctgacgtt catggcggcg gggaaggcgg gccagaacgt ggtgctgtcg ggcttccccg     1440

cgcctgcgct gcaagcgaac gtcttcaagc agccaccggc caccaccacc ggagcggccc     1500

cgccgcagcc ccccggggcc ctgagcaaac ccatgagcgt ccacctcctg aaccaaggca     1560

gcagcatcgt catccccgcc cagcacatgc tgccgggcca gaaccagttc ctactgcctg     1620

gcgccccggc ggtccagctc ccgcagcagc tctcagccct gccggccaac gtgggcgggc     1680

agatcctggc ggccgctgcc ccccacacag gtggacagct catcgcgaac cccatcctca     1740

caaaccagaa cctggcgggc ccactgagcc tgggccccgt gttggccccc cactccgggg     1800

cccacagcgc gcacatcctc tccgccgctc ccatccaggt gggccagcct gcgctcttcc     1860

agatgcccgt gtcgctggcg gcgggcagcc tgcccacgca gagccagcca gcgcccgccg     1920

ggccggccgc caccactgtc ctccaggggg tcaccctgcc ccccagcgcc gtggccatgc     1980

tcaacacccc cgacggcctg gtgcagccgg ccacccctgc cgctgccacc ggggaggccg     2040

cgcctgtcct cacggtgcag cctgcccccc aggcgccccc cgcggtcagc acacccctgc     2100

ccctgggcct ccagcagccg caggcgcagc agcccccgca ggcccccacc ccacaggccg     2160

ccgccccgcc tcaggccacc accccccagc ccagccctgg cctggcgtct agcccggaga     2220

agatcgtcct ggggcagccg ccctctgcca cccccacggc catcctcact caggactccc     2280

tgcagatgtt cctgccccag gagaggagcc agcagcccct ctccgcagag ggcccccacc     2340

tctccgtgcc tgcctcggtc atagtcagcg ccccgcctcc cgcccaagac ccagccccag     2400

ccacccccgt cgccaaagga gctggcctcg gccctcaggc ccccgacagc caggcttccc     2460

cggctccggc cccccagatc ccggcagcgg ctccgctgaa gggcccaggc ccctcttcgt     2520

ccccgtcact acctcaccag gcccctctgg gggacagccc ccacctgccc tccccacacc     2580

ccacccggcc cccttcccgc ccaccctccc ggccacagag tgtgtcccgc cctccctcag     2640

agccaccctt gcacccttgc cccccacccc aggccccccc aactctgcct ggcatctttg     2700

tcatccaaaa ccagctaggc gttcccccgc ctgccagcaa cccggcccct actgccccag     2760

gcccgccgca gccgcctctc cgcccccagt cccagccgcc tgagggaccg ctgcccccag     2820

ccccccacct ccctccatcc tccacctcct ctgctgtggc ctcctcctct gagacgtcct     2880

ccaggttgcc agcccctacg ccatccgact tccagctcca gttcccaccc agccaggggc     2940

cccacaagtc ccccactccc cctccaaccc tccacctggt ccctgagccg gcagcacccc     3000

ccccaccgcc tcctcggacc ttccagatgg tgaccacccc cttcccagcg ctgccccagc     3060

cgaaggctct tctcgagaga tttcaccagg tgccgtccgg aatcatcctc cagaacaagg     3120

ctgggggggc ccctgccgcc ccgcagacct ccaccagcct ggggcccctc accagccccg     3180

ctgcgtctgt gctggtcagt gggcaggccc catctgggac ccccactgcc cccagccacg     3240

cccccgcccc ggcacccatg gccgccacag gcctccctcc tctgcttcca gccgagaaca     3300

aggcttttgc cagcaacctc ccgaccctga atgtggccaa ggccgcttcc tccgggccag     3360

ggaagccctc cgggctgcag tatgagagca aactgagtgg cctgaagaag ccccccacgc     3420

ttcagcccag caaggaagcc tgtttcctgg agcatttgca caaacaccag ggctccgtcc     3480

tgcaccccga ctacaagacg gccttcccct cctttgagga cgccctgcat cgcctcctgc     3540

cctaccatgt ctaccagggc gccctcccct cccccagtga ctaccacaaa gtggacgagg     3600

agtttgagac ggtctccacg cagctgctga aacgcaccca ggccatgctc aataaatatc     3660

ggctcctgct cctggaggag tcccggaggg tgagcccctc agcggagatg gtaatgatcg     3720

accgaatgtt cattcaggag gagaagacca cccttgcctt ggataaacag ctggccaagg     3780

agaagccgga cgagtacgtg tcttcctccc gctcgctcgg cctccccatc gcagcctctt     3840

ccgagggtca tcggcttccc ggccacggcc ccctgtcgtc ttcagctccc ggggcctcca     3900

cccagccccc tccacacctg cccaccaagc ttgtgatccg gcacggcggg gcaggcggct     3960

ccccttcggt cacctgggcc cgggcgtcct cctccctgtc ctcctcttcc tcctcctcct     4020

ctgccgcctc ctccttggac gccgacgagg acggccccat gccctcccgc aaccgcccgc     4080

ccatcaagac ctacgaggcc cggagccgca tcgggctcaa gctcaagatc aagcaggaag     4140

ccgggctcag caaggtcgtg cacaacacgg ccctggaccc cgtgcaccag cccccgccac     4200

cccccgctac cctcaaggtg gccgagcccc cgccacggcc gccaccacca ccgccgccca     4260

cgggccagat gaacggcacg gtggaccacc cgccgcctgc cgcccccgag cgcaagcccc     4320

tgggcaccgc cccgcactgc ccgcgcctgc cactgcgcaa gacctaccgc gagaacgtgg     4380

ggggccctgg cgcgccggag gggacgcccg caggcagggc acggggaggc agcccggcgc     4440

cgctgcccgc caaagtggac gaggccacca gcgggctcat ccgcgagctg gcggccgtgg     4500

aggacgagct gtaccagcgt atgctgaagg gccccccgcc agagcccgca gccagcgccg     4560

cccaaggcac cggggacccc gactgggagg cgcccgggct gccccctgcc aagcggcgca     4620

agtccgagtc gcccgacgtg gaccaggcca gcttctccag cgacagcccg caggatgaca     4680

cgctcaccga gcacctgcag agcgccatcg acagcatcct gaacctgcag caggcccccg     4740

gccggacgcc cgcgccctcg tacccccacg ctgcctcggc cggcaccccc gcatccccgc     4800

cgcccctgca caggcccgag gcctacccac cctccagtca caacggtggc ctcggcgcca     4860

ggacgttgac cagataacac cgggccgcct ccccttcccc gtcccctcct cccgaagacg     4920

ccgggacagt cgggtgtccg ccctcagcct cctggggact cgagccgggg atcccctgac     4980

ggtttttctt gcctaagtta tttgagtcac aaaggcctcc ttccctgccg cctgcttcag     5040

ctgggttgct ggggggtggg cgtggattta gggagggggc tgtgatgtaa aacgtctccc     5100

ctgccaaagg aggggcaaag tgctgtgtca gttcctgttt cttcccattt cctggcacac     5160

tctgcccctc tgtccggggg acacgcgcat gtgtttgcca gggatggggc caccgggttg     5220

atgccaacgc tccgggtgcc tgtcttgtct gtgtggcttc tcagatggtg gagggtgctg     5280

ggagctggca gggtccttcc agacagtctc agcctctccc cgccgccccc aacaggctgt     5340

caaacaaaac cggagagggg gtgggggagc cagcctccca gcgtgctgtg cccgcaggca     5400

cccgtgtgac atccgcacgt ccagctccgt gacctgtgtg tgtgtgtgtg tgcacaagtg     5460

agtgagagat ttcgaacgcc cacccctcga ctttgaaatc tgagcaaaac aagaaactgg     5520

ggtcttcctc tcccccgaac ctctccccag ctagtcttcc ctctgttctt cctgcctcca     5580

gccgcccgcg ccagattttg aaatctcgga gacaaaacta gtactgtaag ataaattttt     5640

ttgtactgta tttattgtgt ataacgattt ttttaaagga gaattctgta catttagaac     5700

tcttgtaaat taaaaaccga tccttttttt aaaactgtaa a                         5741


<210>  12
<211>  1560
<212>  PRT
<213>  Homo sapiens

<400>  12

Met Asp Asp Glu Asp Gly Arg Cys Leu Leu Asp Val Ile Cys Asp Pro 
1               5                   10                  15      


Gln Ala Leu Asn Asp Phe Leu His Gly Ser Glu Lys Leu Asp Ser Asp 
            20                  25                  30          


Asp Leu Leu Asp Asn Pro Gly Glu Ala Gln Ser Ala Phe Tyr Glu Gly 
        35                  40                  45              


Pro Gly Leu His Val Gln Glu Ala Ser Gly Asn His Leu Asn Pro Glu 
    50                  55                  60                  


Pro Asn Gln Pro Ala Pro Ser Val Asp Leu Asp Phe Leu Glu Asp Asp 
65                  70                  75                  80  


Ile Leu Gly Ser Pro Ala Thr Gly Gly Gly Gly Gly Gly Ser Gly Gly 
                85                  90                  95      


Ala Asp Gln Pro Cys Asp Ile Leu Gln Gln Ser Leu Gln Glu Ala Asn 
            100                 105                 110         


Ile Thr Glu Gln Thr Leu Glu Ala Glu Ala Glu Leu Asp Leu Gly Pro 
        115                 120                 125             


Phe Gln Leu Pro Thr Leu Gln Pro Ala Asp Gly Gly Ala Gly Pro Thr 
    130                 135                 140                 


Gly Ala Gly Gly Ala Ala Ala Val Ala Ala Gly Pro Gln Ala Leu Phe 
145                 150                 155                 160 


Pro Gly Ser Thr Asp Leu Leu Gly Leu Gln Gly Pro Pro Thr Val Leu 
                165                 170                 175     


Thr His Gln Ala Leu Val Pro Pro Gln Asp Val Val Asn Lys Ala Leu 
            180                 185                 190         


Ser Val Gln Pro Phe Leu Gln Pro Val Gly Leu Gly Asn Val Thr Leu 
        195                 200                 205             


Gln Pro Ile Pro Gly Leu Gln Gly Leu Pro Asn Gly Ser Pro Gly Gly 
    210                 215                 220                 


Ala Thr Ala Ala Thr Leu Gly Leu Ala Pro Ile Gln Val Val Gly Gln 
225                 230                 235                 240 


Pro Val Met Ala Leu Asn Thr Pro Thr Ser Gln Leu Leu Ala Lys Gln 
                245                 250                 255     


Val Pro Val Ser Gly Tyr Leu Ala Ser Ala Ala Gly Pro Ser Glu Pro 
            260                 265                 270         


Val Thr Leu Ala Ser Ala Gly Val Ser Pro Gln Gly Ala Gly Leu Val 
        275                 280                 285             


Ile Gln Lys Asn Leu Ser Ala Ala Val Ala Thr Thr Leu Asn Gly Asn 
    290                 295                 300                 


Ser Val Phe Gly Gly Ala Gly Ala Ala Ser Ala Pro Thr Gly Thr Pro 
305                 310                 315                 320 


Ser Gly Gln Pro Leu Ala Val Ala Pro Gly Leu Gly Ser Ser Pro Leu 
                325                 330                 335     


Val Pro Ala Pro Asn Val Ile Leu His Arg Thr Pro Thr Pro Ile Gln 
            340                 345                 350         


Pro Lys Pro Ala Gly Val Leu Pro Pro Lys Leu Tyr Gln Leu Thr Pro 
        355                 360                 365             


Lys Pro Phe Ala Pro Ala Gly Ala Thr Leu Thr Ile Gln Gly Glu Pro 
    370                 375                 380                 


Gly Ala Leu Pro Gln Gln Pro Lys Ala Pro Gln Asn Leu Thr Phe Met 
385                 390                 395                 400 


Ala Ala Gly Lys Ala Gly Gln Asn Val Val Leu Ser Gly Phe Pro Ala 
                405                 410                 415     


Pro Ala Leu Gln Ala Asn Val Phe Lys Gln Pro Pro Ala Thr Thr Thr 
            420                 425                 430         


Gly Ala Ala Pro Pro Gln Pro Pro Gly Ala Leu Ser Lys Pro Met Ser 
        435                 440                 445             


Val His Leu Leu Asn Gln Gly Ser Ser Ile Val Ile Pro Ala Gln His 
    450                 455                 460                 


Met Leu Pro Gly Gln Asn Gln Phe Leu Leu Pro Gly Ala Pro Ala Val 
465                 470                 475                 480 


Gln Leu Pro Gln Gln Leu Ser Ala Leu Pro Ala Asn Val Gly Gly Gln 
                485                 490                 495     


Ile Leu Ala Ala Ala Ala Pro His Thr Gly Gly Gln Leu Ile Ala Asn 
            500                 505                 510         


Pro Ile Leu Thr Asn Gln Asn Leu Ala Gly Pro Leu Ser Leu Gly Pro 
        515                 520                 525             


Val Leu Ala Pro His Ser Gly Ala His Ser Ala His Ile Leu Ser Ala 
    530                 535                 540                 


Ala Pro Ile Gln Val Gly Gln Pro Ala Leu Phe Gln Met Pro Val Ser 
545                 550                 555                 560 


Leu Ala Ala Gly Ser Leu Pro Thr Gln Ser Gln Pro Ala Pro Ala Gly 
                565                 570                 575     


Pro Ala Ala Thr Thr Val Leu Gln Gly Val Thr Leu Pro Pro Ser Ala 
            580                 585                 590         


Val Ala Met Leu Asn Thr Pro Asp Gly Leu Val Gln Pro Ala Thr Pro 
        595                 600                 605             


Ala Ala Ala Thr Gly Glu Ala Ala Pro Val Leu Thr Val Gln Pro Ala 
    610                 615                 620                 


Pro Gln Ala Pro Pro Ala Val Ser Thr Pro Leu Pro Leu Gly Leu Gln 
625                 630                 635                 640 


Gln Pro Gln Ala Gln Gln Pro Pro Gln Ala Pro Thr Pro Gln Ala Ala 
                645                 650                 655     


Ala Pro Pro Gln Ala Thr Thr Pro Gln Pro Ser Pro Gly Leu Ala Ser 
            660                 665                 670         


Ser Pro Glu Lys Ile Val Leu Gly Gln Pro Pro Ser Ala Thr Pro Thr 
        675                 680                 685             


Ala Ile Leu Thr Gln Asp Ser Leu Gln Met Phe Leu Pro Gln Glu Arg 
    690                 695                 700                 


Ser Gln Gln Pro Leu Ser Ala Glu Gly Pro His Leu Ser Val Pro Ala 
705                 710                 715                 720 


Ser Val Ile Val Ser Ala Pro Pro Pro Ala Gln Asp Pro Ala Pro Ala 
                725                 730                 735     


Thr Pro Val Ala Lys Gly Ala Gly Leu Gly Pro Gln Ala Pro Asp Ser 
            740                 745                 750         


Gln Ala Ser Pro Ala Pro Ala Pro Gln Ile Pro Ala Ala Ala Pro Leu 
        755                 760                 765             


Lys Gly Pro Gly Pro Ser Ser Ser Pro Ser Leu Pro His Gln Ala Pro 
    770                 775                 780                 


Leu Gly Asp Ser Pro His Leu Pro Ser Pro His Pro Thr Arg Pro Pro 
785                 790                 795                 800 


Ser Arg Pro Pro Ser Arg Pro Gln Ser Val Ser Arg Pro Pro Ser Glu 
                805                 810                 815     


Pro Pro Leu His Pro Cys Pro Pro Pro Gln Ala Pro Pro Thr Leu Pro 
            820                 825                 830         


Gly Ile Phe Val Ile Gln Asn Gln Leu Gly Val Pro Pro Pro Ala Ser 
        835                 840                 845             


Asn Pro Ala Pro Thr Ala Pro Gly Pro Pro Gln Pro Pro Leu Arg Pro 
    850                 855                 860                 


Gln Ser Gln Pro Pro Glu Gly Pro Leu Pro Pro Ala Pro His Leu Pro 
865                 870                 875                 880 


Pro Ser Ser Thr Ser Ser Ala Val Ala Ser Ser Ser Glu Thr Ser Ser 
                885                 890                 895     


Arg Leu Pro Ala Pro Thr Pro Ser Asp Phe Gln Leu Gln Phe Pro Pro 
            900                 905                 910         


Ser Gln Gly Pro His Lys Ser Pro Thr Pro Pro Pro Thr Leu His Leu 
        915                 920                 925             


Val Pro Glu Pro Ala Ala Pro Pro Pro Pro Pro Pro Arg Thr Phe Gln 
    930                 935                 940                 


Met Val Thr Thr Pro Phe Pro Ala Leu Pro Gln Pro Lys Ala Leu Leu 
945                 950                 955                 960 


Glu Arg Phe His Gln Val Pro Ser Gly Ile Ile Leu Gln Asn Lys Ala 
                965                 970                 975     


Gly Gly Ala Pro Ala Ala Pro Gln Thr Ser Thr Ser Leu Gly Pro Leu 
            980                 985                 990         


Thr Ser Pro Ala Ala Ser Val Leu  Val Ser Gly Gln Ala  Pro Ser Gly 
        995                 1000                 1005             


Thr Pro  Thr Ala Pro Ser His  Ala Pro Ala Pro Ala  Pro Met Ala 
    1010                 1015                 1020             


Ala Thr  Gly Leu Pro Pro Leu  Leu Pro Ala Glu Asn  Lys Ala Phe 
    1025                 1030                 1035             


Ala Ser  Asn Leu Pro Thr Leu  Asn Val Ala Lys Ala  Ala Ser Ser 
    1040                 1045                 1050             


Gly Pro  Gly Lys Pro Ser Gly  Leu Gln Tyr Glu Ser  Lys Leu Ser 
    1055                 1060                 1065             


Gly Leu  Lys Lys Pro Pro Thr  Leu Gln Pro Ser Lys  Glu Ala Cys 
    1070                 1075                 1080             


Phe Leu  Glu His Leu His Lys  His Gln Gly Ser Val  Leu His Pro 
    1085                 1090                 1095             


Asp Tyr  Lys Thr Ala Phe Pro  Ser Phe Glu Asp Ala  Leu His Arg 
    1100                 1105                 1110             


Leu Leu  Pro Tyr His Val Tyr  Gln Gly Ala Leu Pro  Ser Pro Ser 
    1115                 1120                 1125             


Asp Tyr  His Lys Val Asp Glu  Glu Phe Glu Thr Val  Ser Thr Gln 
    1130                 1135                 1140             


Leu Leu  Lys Arg Thr Gln Ala  Met Leu Asn Lys Tyr  Arg Leu Leu 
    1145                 1150                 1155             


Leu Leu  Glu Glu Ser Arg Arg  Val Ser Pro Ser Ala  Glu Met Val 
    1160                 1165                 1170             


Met Ile  Asp Arg Met Phe Ile  Gln Glu Glu Lys Thr  Thr Leu Ala 
    1175                 1180                 1185             


Leu Asp  Lys Gln Leu Ala Lys  Glu Lys Pro Asp Glu  Tyr Val Ser 
    1190                 1195                 1200             


Ser Ser  Arg Ser Leu Gly Leu  Pro Ile Ala Ala Ser  Ser Glu Gly 
    1205                 1210                 1215             


His Arg  Leu Pro Gly His Gly  Pro Leu Ser Ser Ser  Ala Pro Gly 
    1220                 1225                 1230             


Ala Ser  Thr Gln Pro Pro Pro  His Leu Pro Thr Lys  Leu Val Ile 
    1235                 1240                 1245             


Arg His  Gly Gly Ala Gly Gly  Ser Pro Ser Val Thr  Trp Ala Arg 
    1250                 1255                 1260             


Ala Ser  Ser Ser Leu Ser Ser  Ser Ser Ser Ser Ser  Ser Ala Ala 
    1265                 1270                 1275             


Ser Ser  Leu Asp Ala Asp Glu  Asp Gly Pro Met Pro  Ser Arg Asn 
    1280                 1285                 1290             


Arg Pro  Pro Ile Lys Thr Tyr  Glu Ala Arg Ser Arg  Ile Gly Leu 
    1295                 1300                 1305             


Lys Leu  Lys Ile Lys Gln Glu  Ala Gly Leu Ser Lys  Val Val His 
    1310                 1315                 1320             


Asn Thr  Ala Leu Asp Pro Val  His Gln Pro Pro Pro  Pro Pro Ala 
    1325                 1330                 1335             


Thr Leu  Lys Val Ala Glu Pro  Pro Pro Arg Pro Pro  Pro Pro Pro 
    1340                 1345                 1350             


Pro Pro  Thr Gly Gln Met Asn  Gly Thr Val Asp His  Pro Pro Pro 
    1355                 1360                 1365             


Ala Ala  Pro Glu Arg Lys Pro  Leu Gly Thr Ala Pro  His Cys Pro 
    1370                 1375                 1380             


Arg Leu  Pro Leu Arg Lys Thr  Tyr Arg Glu Asn Val  Gly Gly Pro 
    1385                 1390                 1395             


Gly Ala  Pro Glu Gly Thr Pro  Ala Gly Arg Ala Arg  Gly Gly Ser 
    1400                 1405                 1410             


Pro Ala  Pro Leu Pro Ala Lys  Val Asp Glu Ala Thr  Ser Gly Leu 
    1415                 1420                 1425             


Ile Arg  Glu Leu Ala Ala Val  Glu Asp Glu Leu Tyr  Gln Arg Met 
    1430                 1435                 1440             


Leu Lys  Gly Pro Pro Pro Glu  Pro Ala Ala Ser Ala  Ala Gln Gly 
    1445                 1450                 1455             


Thr Gly  Asp Pro Asp Trp Glu  Ala Pro Gly Leu Pro  Pro Ala Lys 
    1460                 1465                 1470             


Arg Arg  Lys Ser Glu Ser Pro  Asp Val Asp Gln Ala  Ser Phe Ser 
    1475                 1480                 1485             


Ser Asp  Ser Pro Gln Asp Asp  Thr Leu Thr Glu His  Leu Gln Ser 
    1490                 1495                 1500             


Ala Ile  Asp Ser Ile Leu Asn  Leu Gln Gln Ala Pro  Gly Arg Thr 
    1505                 1510                 1515             


Pro Ala  Pro Ser Tyr Pro His  Ala Ala Ser Ala Gly  Thr Pro Ala 
    1520                 1525                 1530             


Ser Pro  Pro Pro Leu His Arg  Pro Glu Ala Tyr Pro  Pro Ser Ser 
    1535                 1540                 1545             


His Asn  Gly Gly Leu Gly Ala  Arg Thr Leu Thr Arg  
    1550                 1555                 1560 


<210>  13
<211>  5360
<212>  DNA
<213>  Mus musculus

<400>  13
gctggcccca caaaggacat tatcaaagtc cccagcctgg ggccctgtgt agacctggag       60

tggccaccgc acccttccct tcatgattcg ttcatagcac agtggaaatg gatgatgagg      120

atgggagatg cttactagac gtgatttgtg atcctcaggc cctcaatgat ttcttgcatg      180

gatccgagaa gctggacagc gatgacctcc tggatgcccc tgtggaggcc caaagtgcct      240

tctatgaagg tcctgggctc catgtgcagg aagctgccgc caaccaccta aaccctgagc      300

ccagccagcc tgcccccagc gtggacctgg acttcctaga agatgatatc ttgggctccc      360

ctgcagcagg aggaggtgga gggggcggcg gggccccaga ccagccctgt gacatccttc      420

agcagagtct tcaggaggcc aacatcacag aacagaccct ggaggctgag gctgaactgg      480

acctgggccc cttccagctg cccaccctac agcccgctga caatggggca ggtgctactg      540

gagccgcagg agccacggca gtgactgcag gaccccaggc tctcttccca ggcagcgcgg      600

atctgctggg gctgcaagcc ccgcccactg tactgaccca ccaggccctg gtgccacccc      660

aggatgtggt caacaaggcc ttgagcgtcc agcccttcct gcagcctgtg ggcctgggca      720

atgtgaccct tcagcccatt tcaggcctcc agggccttcc caatggcagt cctgggaatg      780

ctgcagcagc caccttgggt ctgacaccta ttcaagtggt gggccagccc gtcatggctc      840

tcaacccacc cacctcccag ctcttggcaa agcaggtacc tgtcagtggc tacctggcct      900

cagcagctgg tccttcagag ccagtgacac tggcatctgc cggcgtgtcc ccccagggag      960

ccggcctggt catccagaaa aatcttccag ccgcagtgac caccacactc aacgggaact     1020

cggtgtttgc cgggacaggg gctgccactg cagcagccag tggggcaccc tcgggacagc     1080

cgctggcggt ggccccgggc cttggcacat caccactggt acaagcaccc agtgtgattt     1140

tacacagaac ccctacgcct atccagccca agcctacagg ggtcctgccc tccaaactct     1200

accagctgac acccaagccc tttcccccta ccggagccac ccttaccatc cagggtgaac     1260

caggcacctt gccccagcag cctaaggccc cccagaacct gacttttatg gccacgggca     1320

aagctggcca gaatgtggtg ctgtctggct tcccggcacc ggctttgcag gcgaatgtgt     1380

tcaagcagcc accagtcacc accacgggga cagccccgcc acagccacca ggggccctca     1440

gcaaacccat gagcgtccac ctcctcaatc aaggcagcag catcgtgatc ccagcccagc     1500

acatgctgcc tggccagaac cagttcttgc tgccaggcac cccagccgta caactccctc     1560

agtcactctc tgcactgcct gccaacgtgg gaggccagat cctcacagct gcagcaccac     1620

acgcaggtgg acagctcatt gccaacccta tcctcaccaa ccagaacctg gcaggcccac     1680

tgagtctggg cccagtgctg gcaccccact ctggggcaca cagcgctgca cacatcctct     1740

ctgcagctcc catccaggtg ggccagcctg ccctcttcca gatgcctgtg tcactggcca     1800

ctggcagcct gcctactcag agccagccgg ctcccactgg ccccacagcc accaccgtcc     1860

tccagggcgt caccctgcct cccagtgctg tggccatgct taacacgcct gatgggctag     1920

tgcaaccctc cactccagct gccaccactg gggaggccac accagttctg gccgttcagc     1980

ctgcaaccca ggtgccccct gctgtcacca caccactgcc tatgggtctc caacagccac     2040

aggcacagca gcctccacag gtccctactc cacaggcggc cacccagcct caggccaccc     2100

ctcctcaggc cagcccaagc ctggcttcca gcccagagaa gatagtcctg gggcaggcgc     2160

cccctgcggc cacaacggcc atcctcactc aggattccct acagatgttc ctgccccagg     2220

agaggagcca gcagcccctc tctacagagg gtccccacct ctcggtgcct gcctccgtca     2280

tagtcagcgc cccgcctcct gcccaagacc cagccctggc cacgcccgtc accaaaggag     2340

ctggcctcgg cgctcagacc ccggacagcc gggcttcccc agctccggct ccccagatcc     2400

ctgcagctgc tccactgaaa gcccctggcc ccgcctcctc cccctcacta cctcaccagg     2460

cccccctggg agacagtccc cacatgccct ccccacaccc tgccaggccc ccttcccgcc     2520

caccctcaag accccactca cgccctccat cccagcccca gagcctgacc tgcccaccct     2580

ctgagcccac cctgcaccct tgccctccac cccagggtcc cccaactcta cctggcatct     2640

ttgtcatcca gaatcaattg ggcgccccac caccagccag caccccagcc tccacagccc     2700

cgggcccacc ccagcctcct ctgcgacccc catcccagcc tccagagggc ccactgcccc     2760

cagcctccca cctccctcct gcctccaccc cctcggccgt ggcctcctcc tctgagcctt     2820

ctgccaggtt gccggtcccc acaccccctg acttccaact ccagttccca ccgagccagg     2880

gaccccataa gtcccctact ccgccaccag ccctccacat ggtccctgag cccacggcac     2940

cccctcctcc accacctcgg accttccaga tggtaaccgc ccccttccca gcgttgcccc     3000

agccaaaagc acttctggaa cgattccacc aggtgccatc tgggattatt ctccagaata     3060

aggctggggg tactcccacc accccacaga catccaccac cctggggacc ctcaccggtc     3120

ctactgcctc tgtgctagtc agtggacagg caccacctgg gactcctgcc gcctctagcc     3180

atgtcccagc ctccacacct atggccacca caggcctccc tcctctactt cctgccgaaa     3240

acaaagcttt tgccagcaac cttccaaccc tgagtgtggc caaagctacc gtgtctgggc     3300

cagggaagcc cccagcaatt cagtatgaca gcaagttgtg tagcttgaag aaacagcccc     3360

tactgcaacc cagcaaagaa gcctgcttcc tggagcatct gcacaaacac cagggctctg     3420

tcctgcaccc cgattacaag acagccttcc cctcctttga ggacgccctc catcgcctcc     3480

tgccctacca tgtctaccaa ggcgccctcc cctcccccaa cgactaccat aaagtggatg     3540

aagaatttga gactgtctct acgcagctgc tcaaacgcac ccaggccatg ctcaataaat     3600

atcggctttt gcttctggaa gagtccagga gagtcagtcc ttctgcggag atggttatga     3660

tcgaccgaat gttcattcag gaggagaaga ccacccttgc cttggataag cagcttgcca     3720

aggagaagcc tgatgagtac gtgtcttcct cccgctccct tggcttccct gtcccagtgt     3780

cttccgaggg ccaccggctc cccagccatg gccagtcgtc ttcatcctcc acatctggaa     3840

cgtctgccca gccccctcct catctgccca ccaagctagt gatccggcac ggtggggccg     3900

gcggctctcc ctcagtgacc tgggcccggg catcctcctc cttgtcatcc acttcctcat     3960

cctcctcctc atcctctgct gcctcatccc tggacgcaga tgaggacggc cccatgccca     4020

cccgtaaccg gccacccatc aagacctatg aggcccggag ccgcattggt ctcaaactca     4080

agatcaaaca agaggcgggg ctcagcaagg tggtgcacaa cactgcactg gatcctgtgc     4140

atcagccctt gccggctcca accccagcga aaggggcgga gcctccgcca cacccagctc     4200

cgcccccact ccctcctgct acccaggcgc agatgaatgg cactctggac catcccccac     4260

ccgcagtacg caaacccacg gtgcctgcgt cctgcccacg tctaccacta cgcaagacct     4320

accgagaaaa catgggcaat cctggtgccg ccgagggtgc acagggacgg ccgcggggtg     4380

cgggcagccc caccccactg cccaccaagg tagacgaagc caccagtggg ctgatccggg     4440

agctggcagc ggtggaggat gaactatatc agcgggttct gaagggcggc ccaccacccc     4500

cggagactcc agcctccgct accagccagg gccccactga acccagttgg gaagcacccg     4560

tgctaccccc agccaaacga cgcaagtctg agtccccgga cgtggaccag gccagcttct     4620

ctagtgacag cccgcaggat gatacactta ctgagcattt gcagagtgcc atcgacagca     4680

tccttaacct gcagcaggcc cccggccgga cacccgcagg cccatacccc catacggggc     4740

ccacgcctgg cacccccaca tccccagcgc ccctgcacag gcctgacgcc ttcccaccct     4800

ctagtcacaa tggtggcctc ggtgccagga cgttgaacag ataacaccgg gctgcttctg     4860

cagccctcat agagtgcccc caaccccact tccaggagag cagcctgacc gccgacctcc     4920

acctctaagg ggcactaacc cagttcccct gacaattctt gcctaagtta ttttgagtca     4980

caaaggcctc cccaccttcc tgcttccacg ttggctagag atttggaatg gggcgtgggt     5040

tttctagggg aaggtgggct ataaggtaca acgtccccct ggcacaagcc aggacagggg     5100

atacatgagt gttgcctagg actgggcttc taggttgatg cactggtaac atctgaaaac     5160

aaggtcttgt ctgattggct tcgtggatca ctgtccgggg cactcagagc cgggagagat     5220

cttctgaaag gctcaactct catcctgttg cccacagagc ctgaaagatt aggaagcaag     5280

gactcaagcc agtgtcccaa agtacctaca tcccatccat acgtgcactc accggagtca     5340

tcctgtgtat gtgtgcgtgc                                                 5360


<210>  14
<211>  1578
<212>  PRT
<213>  Mus musculus

<400>  14

Met Asp Asp Glu Asp Gly Arg Cys Leu Leu Asp Val Ile Cys Asp Pro 
1               5                   10                  15      


Gln Ala Leu Asn Asp Phe Leu His Gly Ser Glu Lys Leu Asp Ser Asp 
            20                  25                  30          


Asp Leu Leu Asp Ala Pro Val Glu Ala Gln Ser Ala Phe Tyr Glu Gly 
        35                  40                  45              


Pro Gly Leu His Val Gln Glu Ala Ala Ala Asn His Leu Asn Pro Glu 
    50                  55                  60                  


Pro Ser Gln Pro Ala Pro Ser Val Asp Leu Asp Phe Leu Glu Asp Asp 
65                  70                  75                  80  


Ile Leu Gly Ser Pro Ala Ala Gly Gly Gly Gly Gly Gly Gly Gly Ala 
                85                  90                  95      


Pro Asp Gln Pro Cys Asp Ile Leu Gln Gln Ser Leu Gln Glu Ala Asn 
            100                 105                 110         


Ile Thr Glu Gln Thr Leu Glu Ala Glu Ala Glu Leu Asp Leu Gly Pro 
        115                 120                 125             


Phe Gln Leu Pro Thr Leu Gln Pro Ala Asp Asn Gly Ala Gly Ala Thr 
    130                 135                 140                 


Gly Ala Ala Gly Ala Thr Ala Val Thr Ala Gly Pro Gln Ala Leu Phe 
145                 150                 155                 160 


Pro Gly Ser Ala Asp Leu Leu Gly Leu Gln Ala Pro Pro Thr Val Leu 
                165                 170                 175     


Thr His Gln Ala Leu Val Pro Pro Gln Asp Val Val Asn Lys Ala Leu 
            180                 185                 190         


Ser Val Gln Pro Phe Leu Gln Pro Val Gly Leu Gly Asn Val Thr Leu 
        195                 200                 205             


Gln Pro Ile Ser Gly Leu Gln Gly Leu Pro Asn Gly Ser Pro Gly Asn 
    210                 215                 220                 


Ala Ala Ala Ala Thr Leu Gly Leu Thr Pro Ile Gln Val Val Gly Gln 
225                 230                 235                 240 


Pro Val Met Ala Leu Asn Pro Pro Thr Ser Gln Leu Leu Ala Lys Gln 
                245                 250                 255     


Val Pro Val Ser Gly Tyr Leu Ala Ser Ala Ala Gly Pro Ser Glu Pro 
            260                 265                 270         


Val Thr Leu Ala Ser Ala Gly Val Ser Pro Gln Gly Ala Gly Leu Val 
        275                 280                 285             


Ile Gln Lys Asn Leu Pro Ala Ala Val Thr Thr Thr Leu Asn Gly Asn 
    290                 295                 300                 


Ser Val Phe Ala Gly Thr Gly Ala Ala Thr Ala Ala Ala Ser Gly Ala 
305                 310                 315                 320 


Pro Ser Gly Gln Pro Leu Ala Val Ala Pro Gly Leu Gly Thr Ser Pro 
                325                 330                 335     


Leu Val Gln Ala Pro Ser Val Ile Leu His Arg Thr Pro Thr Pro Ile 
            340                 345                 350         


Gln Pro Lys Pro Thr Gly Val Leu Pro Ser Lys Leu Tyr Gln Leu Thr 
        355                 360                 365             


Pro Lys Pro Phe Pro Pro Thr Gly Ala Thr Leu Thr Ile Gln Gly Glu 
    370                 375                 380                 


Pro Gly Thr Leu Pro Gln Gln Pro Lys Ala Pro Gln Asn Leu Thr Phe 
385                 390                 395                 400 


Met Ala Thr Gly Lys Ala Gly Gln Asn Val Val Leu Ser Gly Phe Pro 
                405                 410                 415     


Ala Pro Ala Leu Gln Ala Asn Val Phe Lys Gln Pro Pro Val Thr Thr 
            420                 425                 430         


Thr Gly Thr Ala Pro Pro Gln Pro Pro Gly Ala Leu Ser Lys Pro Met 
        435                 440                 445             


Ser Val His Leu Leu Asn Gln Gly Ser Ser Ile Val Ile Pro Ala Gln 
    450                 455                 460                 


His Met Leu Pro Gly Gln Asn Gln Phe Leu Leu Pro Gly Thr Pro Ala 
465                 470                 475                 480 


Val Gln Leu Pro Gln Ser Leu Ser Ala Leu Pro Ala Asn Val Gly Gly 
                485                 490                 495     


Gln Ile Leu Thr Ala Ala Ala Pro His Ala Gly Gly Gln Leu Ile Ala 
            500                 505                 510         


Asn Pro Ile Leu Thr Asn Gln Asn Leu Ala Gly Pro Leu Ser Leu Gly 
        515                 520                 525             


Pro Val Leu Ala Pro His Ser Gly Ala His Ser Ala Ala His Ile Leu 
    530                 535                 540                 


Ser Ala Ala Pro Ile Gln Val Gly Gln Pro Ala Leu Phe Gln Met Pro 
545                 550                 555                 560 


Val Ser Leu Ala Thr Gly Ser Leu Pro Thr Gln Ser Gln Pro Ala Pro 
                565                 570                 575     


Thr Gly Pro Thr Ala Thr Thr Val Leu Gln Gly Val Thr Leu Pro Pro 
            580                 585                 590         


Ser Ala Val Ala Met Leu Asn Thr Pro Asp Gly Leu Val Gln Pro Ser 
        595                 600                 605             


Thr Pro Ala Ala Thr Thr Gly Glu Ala Thr Pro Val Leu Ala Val Gln 
    610                 615                 620                 


Pro Ala Thr Gln Val Pro Pro Ala Val Thr Thr Pro Leu Pro Met Gly 
625                 630                 635                 640 


Leu Gln Gln Pro Gln Ala Gln Gln Pro Pro Gln Val Pro Thr Pro Gln 
                645                 650                 655     


Ala Ala Thr Gln Pro Gln Ala Thr Pro Pro Gln Ala Ser Pro Ser Leu 
            660                 665                 670         


Ala Ser Ser Pro Glu Lys Ile Val Leu Gly Gln Ala Pro Pro Ala Ala 
        675                 680                 685             


Thr Thr Ala Ile Leu Thr Gln Asp Ser Leu Gln Met Phe Leu Pro Gln 
    690                 695                 700                 


Glu Arg Ser Gln Gln Pro Leu Ser Thr Glu Gly Pro His Leu Ser Val 
705                 710                 715                 720 


Pro Ala Ser Val Ile Val Ser Ala Pro Pro Pro Ala Gln Asp Pro Ala 
                725                 730                 735     


Leu Ala Thr Pro Val Thr Lys Gly Ala Gly Leu Gly Ala Gln Thr Pro 
            740                 745                 750         


Asp Ser Arg Ala Ser Pro Ala Pro Ala Pro Gln Ile Pro Ala Ala Ala 
        755                 760                 765             


Pro Leu Lys Ala Pro Gly Pro Ala Ser Ser Pro Ser Leu Pro His Gln 
    770                 775                 780                 


Ala Pro Leu Gly Asp Ser Pro His Met Pro Ser Pro His Pro Ala Arg 
785                 790                 795                 800 


Pro Pro Ser Arg Pro Pro Ser Arg Pro His Ser Arg Pro Pro Ser Gln 
                805                 810                 815     


Pro Gln Ser Leu Thr Cys Pro Pro Ser Glu Pro Thr Leu His Pro Cys 
            820                 825                 830         


Pro Pro Pro Gln Gly Pro Pro Thr Leu Pro Gly Ile Phe Val Ile Gln 
        835                 840                 845             


Asn Gln Leu Gly Ala Pro Pro Pro Ala Ser Thr Pro Ala Ser Thr Ala 
    850                 855                 860                 


Pro Gly Pro Pro Gln Pro Pro Leu Arg Pro Pro Ser Gln Pro Pro Glu 
865                 870                 875                 880 


Gly Pro Leu Pro Pro Ala Ser His Leu Pro Pro Ala Ser Thr Pro Ser 
                885                 890                 895     


Ala Val Ala Ser Ser Ser Glu Pro Ser Ala Arg Leu Pro Val Pro Thr 
            900                 905                 910         


Pro Pro Asp Phe Gln Leu Gln Phe Pro Pro Ser Gln Gly Pro His Lys 
        915                 920                 925             


Ser Pro Thr Pro Pro Pro Ala Leu His Met Val Pro Glu Pro Thr Ala 
    930                 935                 940                 


Pro Pro Pro Pro Pro Pro Arg Thr Phe Gln Met Val Thr Ala Pro Phe 
945                 950                 955                 960 


Pro Ala Leu Pro Gln Pro Lys Ala Leu Leu Glu Arg Phe His Gln Val 
                965                 970                 975     


Pro Ser Gly Ile Ile Leu Gln Asn Lys Ala Gly Gly Thr Pro Thr Thr 
            980                 985                 990         


Pro Gln Thr Ser Thr Thr Leu Gly  Thr Leu Thr Gly Pro  Thr Ala Ser 
        995                 1000                 1005             


Val Leu  Val Ser Gly Gln Ala  Pro Pro Gly Thr Pro  Ala Ala Ser 
    1010                 1015                 1020             


Ser His  Val Pro Ala Ser Thr  Pro Met Ala Thr Thr  Gly Leu Pro 
    1025                 1030                 1035             


Pro Leu  Leu Pro Ala Glu Asn  Lys Ala Phe Ala Ser  Asn Leu Pro 
    1040                 1045                 1050             


Thr Leu  Ser Val Ala Lys Ala  Thr Val Ser Gly Pro  Gly Lys Pro 
    1055                 1060                 1065             


Pro Ala  Ile Gln Tyr Asp Ser  Lys Leu Cys Ser Leu  Lys Lys Gln 
    1070                 1075                 1080             


Pro Leu  Leu Gln Pro Ser Lys  Glu Ala Cys Phe Leu  Glu His Leu 
    1085                 1090                 1095             


His Lys  His Gln Gly Ser Val  Leu His Pro Asp Tyr  Lys Thr Ala 
    1100                 1105                 1110             


Phe Pro  Ser Phe Glu Asp Ala  Leu His Arg Leu Leu  Pro Tyr His 
    1115                 1120                 1125             


Val Tyr  Gln Gly Ala Leu Pro  Ser Pro Asn Asp Tyr  His Lys Val 
    1130                 1135                 1140             


Asp Glu  Glu Phe Glu Thr Val  Ser Thr Gln Leu Leu  Lys Arg Thr 
    1145                 1150                 1155             


Gln Ala  Met Leu Asn Lys Tyr  Arg Leu Leu Leu Leu  Glu Glu Ser 
    1160                 1165                 1170             


Arg Arg  Val Ser Pro Ser Ala  Glu Met Val Met Ile  Asp Arg Met 
    1175                 1180                 1185             


Phe Ile  Gln Glu Glu Lys Thr  Thr Leu Ala Leu Asp  Lys Gln Leu 
    1190                 1195                 1200             


Ala Lys  Glu Lys Pro Asp Glu  Tyr Val Ser Ser Ser  Arg Ser Leu 
    1205                 1210                 1215             


Gly Phe  Pro Val Pro Val Ser  Ser Glu Gly His Arg  Leu Pro Ser 
    1220                 1225                 1230             


His Gly  Gln Ser Ser Ser Ser  Ser Thr Ser Gly Thr  Ser Ala Gln 
    1235                 1240                 1245             


Pro Pro  Pro His Leu Pro Thr  Lys Leu Val Ile Arg  His Gly Gly 
    1250                 1255                 1260             


Ala Gly  Gly Ser Pro Ser Val  Thr Trp Ala Arg Ala  Ser Ser Ser 
    1265                 1270                 1275             


Leu Ser  Ser Thr Ser Ser Ser  Ser Ser Ser Ser Ser  Ala Ala Ser 
    1280                 1285                 1290             


Ser Leu  Asp Ala Asp Glu Asp  Gly Pro Met Pro Thr  Arg Asn Arg 
    1295                 1300                 1305             


Pro Pro  Ile Lys Thr Tyr Glu  Ala Arg Ser Arg Ile  Gly Leu Lys 
    1310                 1315                 1320             


Leu Lys  Ile Lys Gln Glu Ala  Gly Leu Ser Lys Val  Val His Asn 
    1325                 1330                 1335             


Thr Ala  Leu Asp Pro Val His  Gln Pro Leu Pro Ala  Pro Thr Pro 
    1340                 1345                 1350             


Ala Lys  Gly Ala Glu Pro Pro  Pro His Pro Ala Pro  Pro Pro Leu 
    1355                 1360                 1365             


Pro Pro  Ala Thr Gln Ala Gln  Met Asn Gly Thr Leu  Asp His Pro 
    1370                 1375                 1380             


Pro Pro  Ala Val Arg Lys Pro  Thr Val Pro Ala Ser  Cys Pro Arg 
    1385                 1390                 1395             


Leu Pro  Leu Arg Lys Thr Tyr  Arg Glu Asn Met Gly  Asn Pro Gly 
    1400                 1405                 1410             


Ala Ala  Glu Gly Ala Gln Gly  Arg Pro Arg Gly Ala  Gly Ser Pro 
    1415                 1420                 1425             


Thr Pro  Leu Pro Thr Lys Val  Asp Glu Ala Thr Ser  Gly Leu Ile 
    1430                 1435                 1440             


Arg Glu  Leu Ala Ala Val Glu  Asp Glu Leu Tyr Gln  Arg Val Leu 
    1445                 1450                 1455             


Lys Gly  Gly Pro Pro Pro Pro  Glu Thr Pro Ala Ser  Ala Thr Ser 
    1460                 1465                 1470             


Gln Gly  Pro Thr Glu Pro Ser  Trp Glu Ala Pro Val  Leu Pro Pro 
    1475                 1480                 1485             


Ala Lys  Arg Arg Lys Ser Glu  Ser Pro Asp Val Asp  Gln Ala Ser 
    1490                 1495                 1500             


Phe Ser  Ser Asp Ser Pro Gln  Asp Asp Thr Leu Thr  Glu His Leu 
    1505                 1510                 1515             


Gln Ser  Ala Ile Asp Ser Ile  Leu Asn Leu Gln Gln  Ala Pro Gly 
    1520                 1525                 1530             


Arg Thr  Pro Ala Gly Pro Tyr  Pro His Thr Gly Pro  Thr Pro Gly 
    1535                 1540                 1545             


Thr Pro  Thr Ser Pro Ala Pro  Leu His Arg Pro Asp  Ala Phe Pro 
    1550                 1555                 1560             


Pro Ser  Ser His Asn Gly Gly  Leu Gly Ala Arg Thr  Leu Asn Arg 
    1565                 1570                 1575             


<210>  15
<211>  6784
<212>  DNA
<213>  Homo sapiens

<400>  15
ccctgccctc cccgagctcg gtcccggcca ctccctccgc agctgggcgt cgccggccgc       60

gctggggcga gaaccgaagt ttggaggtag acgagcaggc gagcggtttg cccgggcgca      120

gagcatgaag gccgggcggg cgcggggagc ggcgccccgg cccggcgcgg gggtgagcga      180

gagagagagc ggagcgcgtg tggccggcgc cgctcggccg ggagctcccg cgctccggcc      240

cccggccccg cgcccgccgc cgccgccgcc gccgcccctg ttgcgatggc gcagaaaccc      300

cgttgacaag gcactgcttt ttcatgacgc aaaacgtcat attatttcac aaaaagccca      360

gcgatttcac ctgaagaagc ttgggaactc ctgccaaaaa ttgtagcact tctcacattg      420

caatgttgtc atggatgatg atgatgactc gtgtctcctt gatcttattg gagacccaca      480

agcattgaac tattttctac atggacctag taataaatct agcaatgatg acttgactaa      540

tgcaggatat tctgcagcca attcaaattc aattttcgcc aactctagta atgctgatcc      600

taagtcatcc ctcaaaggtg taagcaacca gcttggagaa gggcccagtg atggactgcc      660

actttcaagt agcctccagt ttcttgaaga tgaactcgag tcttctcctc ttcctgatct      720

cactgaggac caacctttcg acattcttca gaaatccttg caagaggcca atatcactga      780

acagacattg gcagaagagg catatttgga tgccagtata ggttcaagcc aacagtttgc      840

acaagctcag cttcatcctt cttcatcagc atcctttact caggcttcta atgtttctaa      900

ttactcaggt cagacgctgc agcctatagg ggtgacgcat gtgcctgttg gagcatcgtt      960

tgcaagcaat acagtgggtg tacaacatgg ctttatgcaa catgtgggga tcagtgttcc     1020

cagccagcat ttgtctaata gcagtcagat tagtggttct ggtcaaatac agttaattgg     1080

gtcatttggt aatcatcctt ccatgatgac tattaataac ctagatggat ctcaaatcat     1140

attaaagggc agcgggcagc aagccccatc aaatgtgagt ggagggctcc tggttcatag     1200

acagactcct aatggcaact ccttgtttgg gaactctagt tccagtccag tagcacagcc     1260

tgttaccgtt ccatttaaca gcacaaattt tcaaacatct ttacctgtgc ataacatcat     1320

catacaaagg ggtcttgcac caaattcaaa taaagtccca attaatatac agccaaagcc     1380

tatccagatg ggtcagcaaa atacatacaa tgtgaacaat ttgggaattc agcagcacca     1440

cgtacaacaa gggatctctt ttgcttctgc aagctcaccc cagggctcag tagttggtcc     1500

acacatgtct gtgaacattg taaaccaaca gaacacaaga aagccagtca cctcacaggc     1560

agtgagcagc actgggggca gtattgttat tcattccccc atgggccaac ctcacgcacc     1620

ccaaagtcag ttccttatac ctacaagcct ttctgtcagt tccaactcgg tacaccacgt     1680

ccagactata aatgggcaac ttcttcaaac tcaaccctct cagctcattt ctggccaagt     1740

ggcctcagag catgtcatgt tgaacagaaa ctcttccaac atgctcagga ccaaccaacc     1800

atatactgga ccgatgctta acaaccagaa tactgctgtc cacttagtgt ctgggcagac     1860

atttgctgcc tctggaagtc cagtgatagc caatcatgcc tctcctcagc ttgtgggtgg     1920

acagatgccc ttgcagcagg catccccaac tgtattacac ctgtcacctg ggcagagcag     1980

cgtttcccaa ggaagacctg gcttcgccac catgccatcg gtgacaagca tgtcaggacc     2040

tagtcggttc cctgctgtca gctcagccag cactgcccat cctagtcttg ggtctgcagt     2100

tcagtctggt tcatcaggat caaactttac aggagatcag ctgacccagc caaacaggac     2160

tccagtacca gtcagtgtgt ctcatcgtct tccagtttct tcttccaagt ctaccagcac     2220

cttcagtaac acacctggaa caggaaccca gcaacaattc ttctgccagg ctcagaaaaa     2280

atgtctgaat cagacttccc ccatttctgc tcccaagacc acagacggcc tgaggcaagc     2340

acagatccct gggctcttga gcaccacact gccagggcag gattctggaa gcaaagttat     2400

atccgcatcc ttaggaaccg cacaaccaca gcaggaaaaa gtagttggat catctcctgg     2460

ccatccagct gtgcaggtgg agagtcattc gggaggacaa aaaaggcctg ctgcgaaaca     2520

gctaacgaaa ggagctttca ttctccagca gttgcagagg gaccaagccc acactgtgac     2580

accagacaaa agtcacttcc gatcactaag tgatgcggta cagagactgc tctcctacca     2640

cgtgtgccag ggctccatgc ccactgaaga agacttgaga aaagtggaca atgaatttga     2700

gacagttgcc actcagctcc taaaaaggac ccaagctatg cttaacaaat acagatgcct     2760

gctcctagaa gatgccatgc gaatcaatcc ctctgctgag atggtgatga tcgataggat     2820

gttcaaccag gaggaaagag cttccctgtc ccgagacaag cgtttggcac ttgtagaccc     2880

tgagggtttt caggctgatt tctgttgttc cttcaaactt gataaagctg ctcatgagac     2940

acagtttggc cggagtgacc agcatggcag taaagcaagc agctctctgc aaccgccagc     3000

caaggcccaa ggcagagacc gagccaaaac cggtgtgacg gaacccatga atcatgacca     3060

gtttcatcta gtgcctaatc acatcgtggt ctctgcagaa ggaaacattt ctaaaaaaac     3120

agaatgcctt ggcagagcac tgaaatttga caaagtgggc ttagtgcagt accagagcac     3180

gtctgaagag aaggccagcc ggagagagcc tctgaaggcc agtcagtgct ctcccggccc     3240

tgaggggcac cggaaaacct catccagatc ggatcatggt actgagagca aactgtcaag     3300

catcctagca gattcgcact tggagatgac gtgtaacaat tccttccagg acaaaagtct     3360

gaggaattct ccaaagaatg aagttttaca cacagacatc atgaaagggt caggcgaacc     3420

ccagccagat ctccagctga caaagagctt ggaaaccaca tttaagaaca tcttggaact     3480

caaaaaggcg ggacggcagc cccagagtga ccccacggtt agcggctctg ttgagttaga     3540

tttccccaac ttttctccta tggcttcaca ggaaaactgc ctggaaaagt tcatcccgga     3600

ccacagtgaa ggtgttgtag aaactgactc cattttagaa gcagctgtaa atagtatcct     3660

agagtgttaa tagcagcagt cctcccccta ccccgccccg agaccccacc ccgagacccc     3720

accccggacc agttacattc gttcctggca aaagcaaatg gaaatggtct cctgtctcca     3780

gcctgcttga tctttcatca caggttattc tttctaatct caatcctgtt ctttgtttaa     3840

gagcaatact tgtcgtgatt acagggagat cctttagtaa aattaatcct tggcagaaag     3900

cagtctgata ggccccactc atttcaagtg ttatgaaagt gcttataggc attttgttta     3960

tttgttttgt tttttaaaaa cactgtaact caatgagacc acagtatact tggcccttgg     4020

taaaattttg acaatcataa gtcatttgaa aagaacagac ttactaaaat caaacgagac     4080

ggatagaagc tactttttaa agaatatccc actgcatctg caaatttagt tttgggtttt     4140

tttattatta ttattttgag tttttttgtg tgtgttttgt tgttattgtt gaggggaaga     4200

ccacatggtt cttccccctc agccatcttt gagcagtaaa ttgctggctg tgctgccagg     4260

gacccgcagc cctggtggaa aagccagtag cacatacgca gggcattgca gggcttccct     4320

attgatggtt caagtgcttt tctgatgctt ccggagcaaa acctcatgct tttaggcata     4380

tctatgttga atttcaccta gggaatgttc tgttcttagt tacagcagca aaatttgaaa     4440

taatttcacc aggctaaata aaggaaaatg gaaaccagtt aagaggcaca gtgtacagag     4500

gaggccggga tagagccatg agggttataa tattaatatg tatatatgta aaagcatata     4560

tatgttaact attgagaaaa aacaagtttt gcattttata attggatata gtcaacatat     4620

aatgtatgtt tttgtttgtt gctggatttt gtttcattta acctctcttt gcaccctctc     4680

ccacaacaaa taccaagcat caaaagcact ttcatttgaa aattattatg ttgtaatttt     4740

tcagtttaaa ctttaaggag actctggcct tgtttatgct tcttgtctga gaacagtagt     4800

gacccctggc agcaattcat taccaaaaca cagacaaacc aaaggtaacc agctagccca     4860

ccactgaaag gaaagatctg agacatggga ttcccatttg agagccaaag gatatgccct     4920

gtcatggttt ctgtttggcc tgtgttcata ttagtgagca tggcttactg ctttatttat     4980

ttttatttct tgtcagggag tattctccgt tttcctttct cgtatacctg ccccaggtta     5040

tcccatttct gttgttacct ttattcttaa tgtcattgta accatcactt atctcctctc     5100

attgggaaag ctacatgata gtatttttat gcactcttct cccacacata cacacacgtg     5160

catgtatctg agctgctcgg atccagaggt catttttgtt acagtgtgtg cacactcact     5220

ctccttctta gtgtgcatac tctctcattt attctgttta tctccctggc tctggaggtg     5280

cagccactgg tcttcacttt aatgtgttgc cagaatctgc ttctggctgt cgccaacatg     5340

gggatgaccc ccattgtcat catgttgggc atttcttttc cagattggcc tgtgatggaa     5400

aggaaggctt ctaattagaa aacacagcaa cagaagacct ataccccggt gcccctgtgt     5460

cccactacac acagaaaacc ctgtgagatg gccagtcttc ataatagcaa cgtaccttca     5520

ccccagccac atgccccagc caatacaaat tggaaaatct ggcccatttt agggttacca     5580

ttttttcctt atttgtgcca atgtccaagt tgcagatttc ccctttttcc tgtattgtaa     5640

catattagat aagttggtgt cgccagttgg tactttctgt ttgggtagtc ctagggtaac     5700

accctgccct aaactccatg atttcatagg cttttcttcc cttggggctc atgctcccct     5760

aattcctagc aagatgatcc ttcctaatca aattcttctc attgcagaac tttatccctg     5820

gaagccttca tgtgggctgc tagtgagtta cattaattac tgcaaatcag tggaattctc     5880

aagagacaag ataagcttca tgtacatttg tcacctctct ttcttcccta tcctgccctg     5940

ctgtcccaat cctagctttt ctatatacca tcctaaaggg tttttaagcc ctaacacttg     6000

tctagcaaat ggagagccta atttaccaaa atgaaacttg taaatttttg tgtcattgta     6060

tgtaagttta ctttttatgg aggaaggatt ctagataatg acaaatgaag attatgacat     6120

gtatttcact cctgtgatta ggttctacgc acatgggtca taactcgcat gtcgagcccc     6180

ctctagtgaa gggtaggaga gctcagcctc ggatggccaa cattcagttg ttcaggttca     6240

ttcgtcaaag ttaagtttta gaactatttg tactcagtaa caaaaatcat tttctttttt     6300

tttttttttt tctgttgtgg aaaagcgtga atttgttatt aagcatttga ttttctgtgt     6360

ccttaagtac ttcctgaaga tgaagcaaaa ttttaatctg gcaattatga aaaagaaata     6420

ttttagctct gaaggattta gtagattctg ttagattagg gaggccttac agactgactt     6480

tacttaaaga ggacgcgtca ctcgctgtca gtgtggtgtg ggctttattt gcttaaatac     6540

cttcatttgt atagtacgtc tcacttgaaa ttgctttgta tacattttgt aaaaatattt     6600

ataaaatgtt ttgtaaaaaa aaaaaaacta taacaaattg cagtttattt tgttatgttg     6660

gataaatact gttaaaagaa accagtcagt aactatattg ttaatccatg gttaggaaat     6720

gtttagttgg agattacaaa ttgaaacaac cattgcaata cagccaaaga tttgggaaaa     6780

tgtg                                                                  6784


<210>  16
<211>  6517
<212>  DNA
<213>  Homo sapiens

<400>  16
ggcatctttt caggatttca ttcctacgtc caactgccgt tcacaactgc cctttccaac       60

tgctccagaa ctcttggccc tggcattccg tgatgtaaat tattccacac atggctcaaa      120

agggtgtgaa gctgtgtgcc aggtgtcgga tcactagttt gtcatggatg atgatgatga      180

ctcgtgtctc cttgatctta ttggagaccc acaagcattg aactattttc tacatggacc      240

tagtaataaa tctagcaatg atgacttgac taatgcagga tattctgcag ccaattcaaa      300

ttcaattttc gccaactcta gtaatgctga tcctaagtca tccctcaaag gtgtaagcaa      360

ccagcttgga gaagggccca gtgatggact gccactttca agtagcctcc agtttcttga      420

agatgaactc gagtcttctc ctcttcctga tctcactgag gaccaacctt tcgacattct      480

tcagaaatcc ttgcaagagg ccaatatcac tgaacagaca ttggcagaag aggcatattt      540

ggatgccagt ataggttcaa gccaacagtt tgcacaagct cagcttcatc cttcttcatc      600

agcatccttt actcaggctt ctaatgtttc taattactca ggtcagacgc tgcagcctat      660

aggggtgacg catgtgcctg ttggagcatc gtttgcaagc aatacagtgg gtgtacaaca      720

tggctttatg caacatgtgg ggatcagtgt tcccagccag catttgtcta atagcagtca      780

gattagtggt tctggtcaaa tacagttaat tgggtcattt ggtaatcatc cttccatgat      840

gactattaat aacctagatg gatctcaaat catattaaag ggcagcgggc agcaagcccc      900

atcaaatgtg agtggagggc tcctggttca tagacagact cctaatggca actccttgtt      960

tgggaactct agttccagtc cagtagcaca gcctgttacc gttccattta acagcacaaa     1020

ttttcaaaca tctttacctg tgcataacat catcatacaa aggggtcttg caccaaattc     1080

aaataaagtc ccaattaata tacagccaaa gcctatccag atgggtcagc aaaatacata     1140

caatgtgaac aatttgggaa ttcagcagca ccacgtacaa caagggatct cttttgcttc     1200

tgcaagctca ccccagggct cagtagttgg tccacacatg tctgtgaaca ttgtaaacca     1260

acagaacaca agaaagccag tcacctcaca ggcagtgagc agcactgggg gcagtattgt     1320

tattcattcc cccatgggcc aacctcacgc accccaaagt cagttcctta tacctacaag     1380

cctttctgtc agttccaact cggtacacca cgtccagact ataaatgggc aacttcttca     1440

aactcaaccc tctcagctca tttctggcca agtggcctca gagcatgtca tgttgaacag     1500

aaactcttcc aacatgctca ggaccaacca accatatact ggaccgatgc ttaacaacca     1560

gaatactgct gtccacttag tgtctgggca gacatttgct gcctctggaa gtccagtgat     1620

agccaatcat gcctctcctc agcttgtggg tggacagatg cccttgcagc aggcatcccc     1680

aactgtatta cacctgtcac ctgggcagag cagcgtttcc caaggaagac ctggcttcgc     1740

caccatgcca tcggtgacaa gcatgtcagg acctagtcgg ttccctgctg tcagctcagc     1800

cagcactgcc catcctagtc ttgggtctgc agttcagtct ggttcatcag gatcaaactt     1860

tacaggagat cagctgaccc agccaaacag gactccagta ccagtcagtg tgtctcatcg     1920

tcttccagtt tcttcttcca agtctaccag caccttcagt aacacacctg gaacaggaac     1980

ccagcaacaa ttcttctgcc aggctcagaa aaaatgtctg aatcagactt cccccatttc     2040

tgctcccaag accacagacg gcctgaggca agcacagatc cctgggctct tgagcaccac     2100

actgccaggg caggattctg gaagcaaagt tatatccgca tccttaggaa ccgcacaacc     2160

acagcaggaa aaagtagttg gatcatctcc tggccatcca gctgtgcagg tggagagtca     2220

ttcgggagga caaaaaaggc ctgctgcgaa acagctaacg aaaggagctt tcattctcca     2280

gcagttgcag agggaccaag cccacactgt gacaccagac aaaagtcact tccgatcact     2340

aagtgatgcg gtacagagac tgctctccta ccacgtgtgc cagggctcca tgcccactga     2400

agaagacttg agaaaagtgg acaatgaatt tgagacagtt gccactcagc tcctaaaaag     2460

gacccaagct atgcttaaca aatacagatg cctgctccta gaagatgcca tgcgaatcaa     2520

tccctctgct gagatggtga tgatcgatag gatgttcaac caggaggaaa gagcttccct     2580

gtcccgagac aagcgtttgg cacttgtaga ccctgagggt tttcaggctg atttctgttg     2640

ttccttcaaa cttgataaag ctgctcatga gacacagttt ggccggagtg accagcatgg     2700

cagtaaagca agcagctctc tgcaaccgcc agccaaggcc caaggcagag accgagccaa     2760

aaccggtgtg acggaaccca tgaatcatga ccagtttcat ctagtgccta atcacatcgt     2820

ggtctctgca gaaggaaaca tttctaaaaa aacagaatgc cttggcagag cactgaaatt     2880

tgacaaagtg ggcttagtgc agtaccagag cacgtctgaa gagaaggcca gccggagaga     2940

gcctctgaag gccagtcagt gctctcccgg ccctgagggg caccggaaaa cctcatccag     3000

atcggatcat ggtactgaga gcaaactgtc aagcatccta gcagattcgc acttggagat     3060

gacgtgtaac aattccttcc aggacaaaag tctgaggaat tctccaaaga atgaagtttt     3120

acacacagac atcatgaaag ggtcaggcga accccagcca gatctccagc tgacaaagag     3180

cttggaaacc acatttaaga acatcttgga actcaaaaag gcgggacggc agccccagag     3240

tgaccccacg gttagcggct ctgttgagtt agatttcccc aacttttctc ctatggcttc     3300

acaggaaaac tgcctggaaa agttcatccc ggaccacagt gaaggtgttg tagaaactga     3360

ctccatttta gaagcagctg taaatagtat cctagagtgt taatagcagc agtcctcccc     3420

ctaccccgcc ccgagacccc accccgagac cccaccccgg accagttaca ttcgttcctg     3480

gcaaaagcaa atggaaatgg tctcctgtct ccagcctgct tgatctttca tcacaggtta     3540

ttctttctaa tctcaatcct gttctttgtt taagagcaat acttgtcgtg attacaggga     3600

gatcctttag taaaattaat ccttggcaga aagcagtctg ataggcccca ctcatttcaa     3660

gtgttatgaa agtgcttata ggcattttgt ttatttgttt tgttttttaa aaacactgta     3720

actcaatgag accacagtat acttggccct tggtaaaatt ttgacaatca taagtcattt     3780

gaaaagaaca gacttactaa aatcaaacga gacggataga agctactttt taaagaatat     3840

cccactgcat ctgcaaattt agttttgggt ttttttatta ttattatttt gagttttttt     3900

gtgtgtgttt tgttgttatt gttgagggga agaccacatg gttcttcccc ctcagccatc     3960

tttgagcagt aaattgctgg ctgtgctgcc agggacccgc agccctggtg gaaaagccag     4020

tagcacatac gcagggcatt gcagggcttc cctattgatg gttcaagtgc ttttctgatg     4080

cttccggagc aaaacctcat gcttttaggc atatctatgt tgaatttcac ctagggaatg     4140

ttctgttctt agttacagca gcaaaatttg aaataatttc accaggctaa ataaaggaaa     4200

atggaaacca gttaagaggc acagtgtaca gaggaggccg ggatagagcc atgagggtta     4260

taatattaat atgtatatat gtaaaagcat atatatgtta actattgaga aaaaacaagt     4320

tttgcatttt ataattggat atagtcaaca tataatgtat gtttttgttt gttgctggat     4380

tttgtttcat ttaacctctc tttgcaccct ctcccacaac aaataccaag catcaaaagc     4440

actttcattt gaaaattatt atgttgtaat ttttcagttt aaactttaag gagactctgg     4500

ccttgtttat gcttcttgtc tgagaacagt agtgacccct ggcagcaatt cattaccaaa     4560

acacagacaa accaaaggta accagctagc ccaccactga aaggaaagat ctgagacatg     4620

ggattcccat ttgagagcca aaggatatgc cctgtcatgg tttctgtttg gcctgtgttc     4680

atattagtga gcatggctta ctgctttatt tatttttatt tcttgtcagg gagtattctc     4740

cgttttcctt tctcgtatac ctgccccagg ttatcccatt tctgttgtta cctttattct     4800

taatgtcatt gtaaccatca cttatctcct ctcattggga aagctacatg atagtatttt     4860

tatgcactct tctcccacac atacacacac gtgcatgtat ctgagctgct cggatccaga     4920

ggtcattttt gttacagtgt gtgcacactc actctccttc ttagtgtgca tactctctca     4980

tttattctgt ttatctccct ggctctggag gtgcagccac tggtcttcac tttaatgtgt     5040

tgccagaatc tgcttctggc tgtcgccaac atggggatga cccccattgt catcatgttg     5100

ggcatttctt ttccagattg gcctgtgatg gaaaggaagg cttctaatta gaaaacacag     5160

caacagaaga cctatacccc ggtgcccctg tgtcccacta cacacagaaa accctgtgag     5220

atggccagtc ttcataatag caacgtacct tcaccccagc cacatgcccc agccaataca     5280

aattggaaaa tctggcccat tttagggtta ccattttttc cttatttgtg ccaatgtcca     5340

agttgcagat ttcccctttt tcctgtattg taacatatta gataagttgg tgtcgccagt     5400

tggtactttc tgtttgggta gtcctagggt aacaccctgc cctaaactcc atgatttcat     5460

aggcttttct tcccttgggg ctcatgctcc cctaattcct agcaagatga tccttcctaa     5520

tcaaattctt ctcattgcag aactttatcc ctggaagcct tcatgtgggc tgctagtgag     5580

ttacattaat tactgcaaat cagtggaatt ctcaagagac aagataagct tcatgtacat     5640

ttgtcacctc tctttcttcc ctatcctgcc ctgctgtccc aatcctagct tttctatata     5700

ccatcctaaa gggtttttaa gccctaacac ttgtctagca aatggagagc ctaatttacc     5760

aaaatgaaac ttgtaaattt ttgtgtcatt gtatgtaagt ttacttttta tggaggaagg     5820

attctagata atgacaaatg aagattatga catgtatttc actcctgtga ttaggttcta     5880

cgcacatggg tcataactcg catgtcgagc cccctctagt gaagggtagg agagctcagc     5940

ctcggatggc caacattcag ttgttcaggt tcattcgtca aagttaagtt ttagaactat     6000

ttgtactcag taacaaaaat cattttcttt tttttttttt ttttctgttg tggaaaagcg     6060

tgaatttgtt attaagcatt tgattttctg tgtccttaag tacttcctga agatgaagca     6120

aaattttaat ctggcaatta tgaaaaagaa atattttagc tctgaaggat ttagtagatt     6180

ctgttagatt agggaggcct tacagactga ctttacttaa agaggacgcg tcactcgctg     6240

tcagtgtggt gtgggcttta tttgcttaaa taccttcatt tgtatagtac gtctcacttg     6300

aaattgcttt gtatacattt tgtaaaaata tttataaaat gttttgtaaa aaaaaaaaaa     6360

ctataacaaa ttgcagttta ttttgttatg ttggataaat actgttaaaa gaaaccagtc     6420

agtaactata ttgttaatcc atggttagga aatgtttagt tggagattac aaattgaaac     6480

aaccattgca atacagccaa agatttggga aaatgtg                              6517


<210>  17
<211>  1079
<212>  PRT
<213>  Homo sapiens

<400>  17

Met Asp Asp Asp Asp Asp Ser Cys Leu Leu Asp Leu Ile Gly Asp Pro 
1               5                   10                  15      


Gln Ala Leu Asn Tyr Phe Leu His Gly Pro Ser Asn Lys Ser Ser Asn 
            20                  25                  30          


Asp Asp Leu Thr Asn Ala Gly Tyr Ser Ala Ala Asn Ser Asn Ser Ile 
        35                  40                  45              


Phe Ala Asn Ser Ser Asn Ala Asp Pro Lys Ser Ser Leu Lys Gly Val 
    50                  55                  60                  


Ser Asn Gln Leu Gly Glu Gly Pro Ser Asp Gly Leu Pro Leu Ser Ser 
65                  70                  75                  80  


Ser Leu Gln Phe Leu Glu Asp Glu Leu Glu Ser Ser Pro Leu Pro Asp 
                85                  90                  95      


Leu Thr Glu Asp Gln Pro Phe Asp Ile Leu Gln Lys Ser Leu Gln Glu 
            100                 105                 110         


Ala Asn Ile Thr Glu Gln Thr Leu Ala Glu Glu Ala Tyr Leu Asp Ala 
        115                 120                 125             


Ser Ile Gly Ser Ser Gln Gln Phe Ala Gln Ala Gln Leu His Pro Ser 
    130                 135                 140                 


Ser Ser Ala Ser Phe Thr Gln Ala Ser Asn Val Ser Asn Tyr Ser Gly 
145                 150                 155                 160 


Gln Thr Leu Gln Pro Ile Gly Val Thr His Val Pro Val Gly Ala Ser 
                165                 170                 175     


Phe Ala Ser Asn Thr Val Gly Val Gln His Gly Phe Met Gln His Val 
            180                 185                 190         


Gly Ile Ser Val Pro Ser Gln His Leu Ser Asn Ser Ser Gln Ile Ser 
        195                 200                 205             


Gly Ser Gly Gln Ile Gln Leu Ile Gly Ser Phe Gly Asn His Pro Ser 
    210                 215                 220                 


Met Met Thr Ile Asn Asn Leu Asp Gly Ser Gln Ile Ile Leu Lys Gly 
225                 230                 235                 240 


Ser Gly Gln Gln Ala Pro Ser Asn Val Ser Gly Gly Leu Leu Val His 
                245                 250                 255     


Arg Gln Thr Pro Asn Gly Asn Ser Leu Phe Gly Asn Ser Ser Ser Ser 
            260                 265                 270         


Pro Val Ala Gln Pro Val Thr Val Pro Phe Asn Ser Thr Asn Phe Gln 
        275                 280                 285             


Thr Ser Leu Pro Val His Asn Ile Ile Ile Gln Arg Gly Leu Ala Pro 
    290                 295                 300                 


Asn Ser Asn Lys Val Pro Ile Asn Ile Gln Pro Lys Pro Ile Gln Met 
305                 310                 315                 320 


Gly Gln Gln Asn Thr Tyr Asn Val Asn Asn Leu Gly Ile Gln Gln His 
                325                 330                 335     


His Val Gln Gln Gly Ile Ser Phe Ala Ser Ala Ser Ser Pro Gln Gly 
            340                 345                 350         


Ser Val Val Gly Pro His Met Ser Val Asn Ile Val Asn Gln Gln Asn 
        355                 360                 365             


Thr Arg Lys Pro Val Thr Ser Gln Ala Val Ser Ser Thr Gly Gly Ser 
    370                 375                 380                 


Ile Val Ile His Ser Pro Met Gly Gln Pro His Ala Pro Gln Ser Gln 
385                 390                 395                 400 


Phe Leu Ile Pro Thr Ser Leu Ser Val Ser Ser Asn Ser Val His His 
                405                 410                 415     


Val Gln Thr Ile Asn Gly Gln Leu Leu Gln Thr Gln Pro Ser Gln Leu 
            420                 425                 430         


Ile Ser Gly Gln Val Ala Ser Glu His Val Met Leu Asn Arg Asn Ser 
        435                 440                 445             


Ser Asn Met Leu Arg Thr Asn Gln Pro Tyr Thr Gly Pro Met Leu Asn 
    450                 455                 460                 


Asn Gln Asn Thr Ala Val His Leu Val Ser Gly Gln Thr Phe Ala Ala 
465                 470                 475                 480 


Ser Gly Ser Pro Val Ile Ala Asn His Ala Ser Pro Gln Leu Val Gly 
                485                 490                 495     


Gly Gln Met Pro Leu Gln Gln Ala Ser Pro Thr Val Leu His Leu Ser 
            500                 505                 510         


Pro Gly Gln Ser Ser Val Ser Gln Gly Arg Pro Gly Phe Ala Thr Met 
        515                 520                 525             


Pro Ser Val Thr Ser Met Ser Gly Pro Ser Arg Phe Pro Ala Val Ser 
    530                 535                 540                 


Ser Ala Ser Thr Ala His Pro Ser Leu Gly Ser Ala Val Gln Ser Gly 
545                 550                 555                 560 


Ser Ser Gly Ser Asn Phe Thr Gly Asp Gln Leu Thr Gln Pro Asn Arg 
                565                 570                 575     


Thr Pro Val Pro Val Ser Val Ser His Arg Leu Pro Val Ser Ser Ser 
            580                 585                 590         


Lys Ser Thr Ser Thr Phe Ser Asn Thr Pro Gly Thr Gly Thr Gln Gln 
        595                 600                 605             


Gln Phe Phe Cys Gln Ala Gln Lys Lys Cys Leu Asn Gln Thr Ser Pro 
    610                 615                 620                 


Ile Ser Ala Pro Lys Thr Thr Asp Gly Leu Arg Gln Ala Gln Ile Pro 
625                 630                 635                 640 


Gly Leu Leu Ser Thr Thr Leu Pro Gly Gln Asp Ser Gly Ser Lys Val 
                645                 650                 655     


Ile Ser Ala Ser Leu Gly Thr Ala Gln Pro Gln Gln Glu Lys Val Val 
            660                 665                 670         


Gly Ser Ser Pro Gly His Pro Ala Val Gln Val Glu Ser His Ser Gly 
        675                 680                 685             


Gly Gln Lys Arg Pro Ala Ala Lys Gln Leu Thr Lys Gly Ala Phe Ile 
    690                 695                 700                 


Leu Gln Gln Leu Gln Arg Asp Gln Ala His Thr Val Thr Pro Asp Lys 
705                 710                 715                 720 


Ser His Phe Arg Ser Leu Ser Asp Ala Val Gln Arg Leu Leu Ser Tyr 
                725                 730                 735     


His Val Cys Gln Gly Ser Met Pro Thr Glu Glu Asp Leu Arg Lys Val 
            740                 745                 750         


Asp Asn Glu Phe Glu Thr Val Ala Thr Gln Leu Leu Lys Arg Thr Gln 
        755                 760                 765             


Ala Met Leu Asn Lys Tyr Arg Cys Leu Leu Leu Glu Asp Ala Met Arg 
    770                 775                 780                 


Ile Asn Pro Ser Ala Glu Met Val Met Ile Asp Arg Met Phe Asn Gln 
785                 790                 795                 800 


Glu Glu Arg Ala Ser Leu Ser Arg Asp Lys Arg Leu Ala Leu Val Asp 
                805                 810                 815     


Pro Glu Gly Phe Gln Ala Asp Phe Cys Cys Ser Phe Lys Leu Asp Lys 
            820                 825                 830         


Ala Ala His Glu Thr Gln Phe Gly Arg Ser Asp Gln His Gly Ser Lys 
        835                 840                 845             


Ala Ser Ser Ser Leu Gln Pro Pro Ala Lys Ala Gln Gly Arg Asp Arg 
    850                 855                 860                 


Ala Lys Thr Gly Val Thr Glu Pro Met Asn His Asp Gln Phe His Leu 
865                 870                 875                 880 


Val Pro Asn His Ile Val Val Ser Ala Glu Gly Asn Ile Ser Lys Lys 
                885                 890                 895     


Thr Glu Cys Leu Gly Arg Ala Leu Lys Phe Asp Lys Val Gly Leu Val 
            900                 905                 910         


Gln Tyr Gln Ser Thr Ser Glu Glu Lys Ala Ser Arg Arg Glu Pro Leu 
        915                 920                 925             


Lys Ala Ser Gln Cys Ser Pro Gly Pro Glu Gly His Arg Lys Thr Ser 
    930                 935                 940                 


Ser Arg Ser Asp His Gly Thr Glu Ser Lys Leu Ser Ser Ile Leu Ala 
945                 950                 955                 960 


Asp Ser His Leu Glu Met Thr Cys Asn Asn Ser Phe Gln Asp Lys Ser 
                965                 970                 975     


Leu Arg Asn Ser Pro Lys Asn Glu Val Leu His Thr Asp Ile Met Lys 
            980                 985                 990         


Gly Ser Gly Glu Pro Gln Pro Asp  Leu Gln Leu Thr Lys  Ser Leu Glu 
        995                 1000                 1005             


Thr Thr  Phe Lys Asn Ile Leu  Glu Leu Lys Lys Ala  Gly Arg Gln 
    1010                 1015                 1020             


Pro Gln  Ser Asp Pro Thr Val  Ser Gly Ser Val Glu  Leu Asp Phe 
    1025                 1030                 1035             


Pro Asn  Phe Ser Pro Met Ala  Ser Gln Glu Asn Cys  Leu Glu Lys 
    1040                 1045                 1050             


Phe Ile  Pro Asp His Ser Glu  Gly Val Val Glu Thr  Asp Ser Ile 
    1055                 1060                 1065             


Leu Glu  Ala Ala Val Asn Ser  Ile Leu Glu Cys 
    1070                 1075                 


<210>  18
<211>  6579
<212>  DNA
<213>  Mus musculus

<400>  18
ggggtctcat gtagcccagg ctggcctcaa ccttgtcatg taggcaaggg tagccttcac       60

ctcctgatcc tcctgtctct gccttccaac tcctgggatc aaggtgtttg ccagtgtgtc      120

tggcttgctt ggctatttgt ttatttactt atgagctgcg gtcttgctat tgtccaggct      180

gaccttgaac tcttggactc aagttccctt ccttactgag tcctacctga gtggccagga      240

ctactggcaa atgacactgt gcccaccagc cacaacattt ttcccatggt aggcttgata      300

ggtgactagg gaaagctccc gtgctgacag ttgtgtggag gctcagcgtg ctccactgca      360

tccatattgc tggccgccct gctccgactc actgcctccc tccctctctc cttgcagttg      420

tcatggatga tgacgatgac tcctgtctcc tcgatcttat tggagaccca caagcattga      480

actattttct gcacggacct agcagtaaat cgggcagcga tgatgtgacg aacgcagggt      540

attctgcagc caattctaat tcaattttcg ccaactccac gaacgctgac cctaaatcgg      600

ccctcaaagg tgtgagtgac cagcttgggg aggggcccag tgatgggctg ccgcttgcaa      660

gcagccttca gtttcttgaa gatgaacttg agtcttcacc tctccccgat ctcagcgagg      720

accaaccctt tgacattctt cagaaatcct tgcaggaggc taatatcact gaacagacat      780

tggcagaaga ggcgtacctg gatgccagta taggctcaag ccaacagttt gcacaagccc      840

agcttcatcc ttcttcatca gcatccttta ctcaggcttc taatgtttct aattactcag      900

gtcagacact gcagcctatc ggggtgactc acgtgcctgt tggagcatcg tttgcaagca      960

atacagtggg tgtgcagcat ggctttatgc aacacgtggg gatcagtgtt cccagccagc     1020

atttgcctaa cagcagccag attagtggct ccggtcagat acagttaatc gggtccttcg     1080

gtaatcagcc ttccatgatg actataaata acctcgatgg ctctcaaatc atactgaaag     1140

gcagtgggca gcaagcccca tctaatgtga gtggggggct tctggttcac agacagactc     1200

ctaacggcaa ctctctgttt gggaactcca cttccagtcc tgtagcacag cctgtcaccg     1260

ttccatttaa cagcacaaat ttccaggcat ctttacccgt gcataacatc attattcaaa     1320

ggggtcttgc accaaattca aataaagtcc caattaatat ccagccaaag ccggtccaga     1380

tgggtcagca gagcgcgtac aatgtgaaca accttgggat ccagcagcac catgcccagc     1440

aggggatctc cttcgccccc acaagctcgc cccagggctc cgtggttggg ccgcacatgt     1500

ctgtgaacat tgtcaaccaa cagaacacga gaaagcctgt cacctcgcag gcagtgagcg     1560

gcacaggggg cagcatcgtc atccattccc ccatgggcca gcctcacact ccccaaagtc     1620

agttccttat acccacaagc ctttctgtca gctccaactc ggtgcaccat gtccaggcta     1680

taaacgggca gctgcttcag actcagccct cccagctcat ctctggccaa gtggcctctg     1740

agcatgtcat gctgaacagg aattcctcta acatgctcag gaccaaccaa ccatattccg     1800

gacagatgct taataaccag aataccgccg tccagctggt gtctgggcag acttttgcca     1860

cctctggaag tccagtgata gtcaaccacg cctctcctca gatcgtcggg ggacagatgc     1920

ccttgcagca ggcctcaccc accgtgttac acctgtcacc tgggcagagc agtgtttccc     1980

agggaaggcc aggcttcgcc accatgcccg cggtgagcgg catggcagga cccgctcggt     2040

tccccgccgt cagctcagct agcactgctc atcctactct tgggcctacg gtgcagtcgg     2100

gggcaccggg atcaaacttt acgggagacc agctgacaca agccaacaga acgccagcgc     2160

ccgtcagtgt gtcccaccgt cttccagtct ctgcttccaa atcccccagc accttgagca     2220

acaccccggg gacacagcag cagttcttct gtcaggctca gaagaagtgt ttgaaccaga     2280

cctcccccat tcccacatcc aagaccacag acggcttgag gccatcacag atccctgggc     2340

tcttgagcac cgcactgcca ggacaggatt ctggaagcaa aattatgcca gcgaccttgg     2400

gggccacaca ggcacaacca gaaagctcag ttggatcatc cccgagccag acagctgtgc     2460

aggtggatag tcatccagga cagaaaaggc ctgctgccaa acagctgact aaaggagctt     2520

tcatcctcca gcagttacag agggaccaag cccatgctgt gacacccgac aaaagccagt     2580

tccggtcact aaatgacacg gtgcagagac tgctctccta ccacgtgtgc cagggctcca     2640

tgcccacgga ggaagacctg aggcaagtgg acaatgaatt tgaagaggtc gccactcagc     2700

tcctcaaaag gacccaagct atgctgaaca aatacagatt cctgctccta gaagacgcca     2760

tgaggatcaa cccctctgca gagatggtga tgattgacag gatgttcaac caggaggaaa     2820

gagcttccct gtcgagggac aagcgtctgg cgctcgtaga tcctgagggt tttcaggccg     2880

atttctgttg ttccttcaaa cttgacgaag ctgtacctga gaccccgctt gacaggagtg     2940

accagcatcg cagcaaaacc agctcgctcc atcaggtgcc cagggcccaa agcagagacc     3000

gagccaagcc aggcatggca gaagcaacga atcatgacca gtttcatcta gtgcctaacc     3060

acatcgtggt ctctgcagag ggaaacattt ctaaaaagtc agaaggccac agtagaacac     3120

tgaaatttga cagaggggtc ttaggccaat accggggtcc gcctgaggac aagggcggcc     3180

ggagggaccc tgccaaggtc agcaggtgct ctccgggccc cgagggccac cgcaaaagct     3240

tgcccaggcc agatcacggc tctgagagca agctccccgg cgtcctggcc agctcgcaca     3300

tggagatgcc ctgtctcgac tccttccagg acaaagcgct gaggaattcc ccaaagaatg     3360

aggttttaca cacagacatc atgaaagggt cgggtgagcc ccagccagat ctccagctca     3420

ccaagagcct agagaaaacc tttaagaaca tcctggaact caagaactcg gggcggccgc     3480

caagcgaccc tacggccagc ggtgcggcgg acctggactt ccccagcttt tctccaatgg     3540

cttcgcagga aaactgccta gaaaaattca tcccggacca cagtgaaggc gttgtagaaa     3600

cggactccat tttagaagca gctgtaaata gtattctaga gtgttaatag cagccgtcct     3660

cctccagacc ctgccccgga ccagttacac tctctcccag caaagcaaat ggaaacggct     3720

cccgtctgtc tccagcctgc ttggtcctcc atcacaggtt atcctttcta atctcaccct     3780

gttcttttga agagcaatac atgtcgtcat ggctgcgggg agacccctca gtacacccac     3840

ctctctctag aaagcagtcc gataggccct ccacatttca agtgttacga aagtgcttac     3900

ggccattgtt gttcgttaat ttgttttgtg gtttgtttct tagcactgtc gctcaagacc     3960

acagtacact tggccctggg taaaattttg acaatcataa gtcatttcaa aagaacagac     4020

ttattaaaga aaaatcaaac aggactgatt taaagacttt ctcactgcag ctccaaagta     4080

gtggtttggt tttgttctgt tccaggggga gagggtatct gcgtagggaa gactctccct     4140

gaccagcccg ctgagtggtg ggtagccggt gctctgcctg gaagcccacc gccctggcta     4200

agacgccagg agcacagcca cagagcatcc tcctgacatc cagtgctgtg cgatgctgca     4260

aaagcaaagc cttgtgtttg tcttcaacac attcgtgctg aattctgtct gagaatggtc     4320

tgttcttagc cccaggtgta cgccctgaaa ttctcacagg ctcactaggg aacagtggaa     4380

gtcagttgta aggcagcgag ttggggaggc accggggtct ccgtgtattc catcaactta     4440

aaagaggttt gcattttata attgggtgaa gtcaacataa cctatgttct ttattatcgc     4500

tgaattctgt tccattcaac ctcgttgtcc cctttccctc agcccttagc caagcatcaa     4560

aaggctttca cttaaaaact gtgttgtact ctttcagttg aggcttttga acgggactct     4620

ggccttgttc gtgagaatag tagtcaacag tatcagtcat tcattcccaa acacagtaaa     4680

ccaaaggtca caaccagcag gccactgaag gaaggaaccg aggcaggaga cagggggcca     4740

tgtcctggcc ccgcccccgc tgtgtgtggt ccagttcacc atagcgatcg agccttcctc     4800

tttattattt ttgttccttt ccgggagtgg ccctcatcct tccctctgtg cgggcctgca     4860

ccagggcgtg ttctgttgct acttgcttct tcctgtgtgg taatggccca cagtgctgtg     4920

tctgcaaccc tcctcccacg tctccatcaa cctctgggat ccagaggtag ctttgatgcc     4980

tgtgagggct tcctccctct gttcatcccc aggctgtgta aatgcatccg ttgatctcct     5040

ctgcttcgtt atacccccaa aatggagttg tccctatggt catcatgtag agtgtttctt     5100

ttccagattg gcctgcaatg gaaaggaagg cttttgattt tgatttttat ctttttttca     5160

cataacacag caacaatcta ggcatggtgg catacacctg taatcccaac agtcaggtga     5220

ctaaagcagg agagtcactg gttcaaggcc agcttgggct atataacaca cccctgcctc     5280

aaacacagaa ggagagaaat ttgagcaata gcagactgtg tgggcctttt ttacccctct     5340

gtccactaca caaaaaaact ctgtgagaca gccagtcttt gagagcgatg gaccttctcc     5400

cgcccacagc ccagccaacc aaactagaag agtctgggct gtcttcgagt tgtccttttc     5460

ttccttctct gtgccaatgt ccaagttgct gacttccttc ctgtattata acacattaga     5520

aagatgagtt gtttaccagt tagacctctg tctgggctgc cctgatctct ctgtcacagg     5580

ctcttctcat agccacatgg ttaccattca agatggcccc tggatgcctg cagcacatgg     5640

ctactaatga attactttaa ttattgcaaa tcagtggaat tctcaagaga caagaaagtc     5700

tcgtgtatat ttgttatctc ttccctccct ccccagcccc ggccctggcc ctagttttct     5760

ctcctgtgtg tcaggttaca gggcttctca ccatgacatt agtcccacac aaggagagcc     5820

tactgtacca aaatgaaact tgtaaatttt tgtgtccttg tatgtaagtt tactttttat     5880

ggaggaaaga ctctagataa tgacaaatga agattacaaa gtgtatttta ctcctgtgat     5940

taggttacac cacatgggtc ataactcact cccgagcccc cactgctgaa gggaagcgct     6000

ctgcctcagt ggccaacgtt ggtggttcag ggtcattagt cagttgagtt ctagaacgcg     6060

tgctcagtaa caaaaaaaaa aaatcacctt ttcttccctt tgtttttaat ccgtttgttg     6120

ttgtggaaaa gtatgaattt gttattacgc attgattttc tgtgtcctta agtactgcct     6180

aaagatgaag caaattttga actggcaatt acgataagga aaccctttag ttctggagac     6240

tttagtagac tctgttagat tagggaggcc tcacaggctg gccggctcca aggacggtca     6300

ctcactgtca gtgtggcgtg gctttatttg cttaaatacc ttcatttgta tagtatgtct     6360

cacttgaaat tgctttgtat acattttgta aaaatattta taaaatgttt tgtaaaaaaa     6420

aaaaaaagta taacaaattg cagtttattt tgttatgttg gataaatact gttaaaccag     6480

tcagtaccta tattgttaat ccatggttag ggtatgttca gttggagatt acaaaatgaa     6540

acaaccattg caatacagcc aaagatttgg gaaaacgtg                            6579


<210>  19
<211>  1074
<212>  PRT
<213>  Mus musculus

<400>  19

Met Asp Asp Asp Asp Asp Ser Cys Leu Leu Asp Leu Ile Gly Asp Pro 
1               5                   10                  15      


Gln Ala Leu Asn Tyr Phe Leu His Gly Pro Ser Ser Lys Ser Gly Ser 
            20                  25                  30          


Asp Asp Val Thr Asn Ala Gly Tyr Ser Ala Ala Asn Ser Asn Ser Ile 
        35                  40                  45              


Phe Ala Asn Ser Thr Asn Ala Asp Pro Lys Ser Ala Leu Lys Gly Val 
    50                  55                  60                  


Ser Asp Gln Leu Gly Glu Gly Pro Ser Asp Gly Leu Pro Leu Ala Ser 
65                  70                  75                  80  


Ser Leu Gln Phe Leu Glu Asp Glu Leu Glu Ser Ser Pro Leu Pro Asp 
                85                  90                  95      


Leu Ser Glu Asp Gln Pro Phe Asp Ile Leu Gln Lys Ser Leu Gln Glu 
            100                 105                 110         


Ala Asn Ile Thr Glu Gln Thr Leu Ala Glu Glu Ala Tyr Leu Asp Ala 
        115                 120                 125             


Ser Ile Gly Ser Ser Gln Gln Phe Ala Gln Ala Gln Leu His Pro Ser 
    130                 135                 140                 


Ser Ser Ala Ser Phe Thr Gln Ala Ser Asn Val Ser Asn Tyr Ser Gly 
145                 150                 155                 160 


Gln Thr Leu Gln Pro Ile Gly Val Thr His Val Pro Val Gly Ala Ser 
                165                 170                 175     


Phe Ala Ser Asn Thr Val Gly Val Gln His Gly Phe Met Gln His Val 
            180                 185                 190         


Gly Ile Ser Val Pro Ser Gln His Leu Pro Asn Ser Ser Gln Ile Ser 
        195                 200                 205             


Gly Ser Gly Gln Ile Gln Leu Ile Gly Ser Phe Gly Asn Gln Pro Ser 
    210                 215                 220                 


Met Met Thr Ile Asn Asn Leu Asp Gly Ser Gln Ile Ile Leu Lys Gly 
225                 230                 235                 240 


Ser Gly Gln Gln Ala Pro Ser Asn Val Ser Gly Gly Leu Leu Val His 
                245                 250                 255     


Arg Gln Thr Pro Asn Gly Asn Ser Leu Phe Gly Asn Ser Thr Ser Ser 
            260                 265                 270         


Pro Val Ala Gln Pro Val Thr Val Pro Phe Asn Ser Thr Asn Phe Gln 
        275                 280                 285             


Ala Ser Leu Pro Val His Asn Ile Ile Ile Gln Arg Gly Leu Ala Pro 
    290                 295                 300                 


Asn Ser Asn Lys Val Pro Ile Asn Ile Gln Pro Lys Pro Val Gln Met 
305                 310                 315                 320 


Gly Gln Gln Ser Ala Tyr Asn Val Asn Asn Leu Gly Ile Gln Gln His 
                325                 330                 335     


His Ala Gln Gln Gly Ile Ser Phe Ala Pro Thr Ser Ser Pro Gln Gly 
            340                 345                 350         


Ser Val Val Gly Pro His Met Ser Val Asn Ile Val Asn Gln Gln Asn 
        355                 360                 365             


Thr Arg Lys Pro Val Thr Ser Gln Ala Val Ser Gly Thr Gly Gly Ser 
    370                 375                 380                 


Ile Val Ile His Ser Pro Met Gly Gln Pro His Thr Pro Gln Ser Gln 
385                 390                 395                 400 


Phe Leu Ile Pro Thr Ser Leu Ser Val Ser Ser Asn Ser Val His His 
                405                 410                 415     


Val Gln Ala Ile Asn Gly Gln Leu Leu Gln Thr Gln Pro Ser Gln Leu 
            420                 425                 430         


Ile Ser Gly Gln Val Ala Ser Glu His Val Met Leu Asn Arg Asn Ser 
        435                 440                 445             


Ser Asn Met Leu Arg Thr Asn Gln Pro Tyr Ser Gly Gln Met Leu Asn 
    450                 455                 460                 


Asn Gln Asn Thr Ala Val Gln Leu Val Ser Gly Gln Thr Phe Ala Thr 
465                 470                 475                 480 


Ser Gly Ser Pro Val Ile Val Asn His Ala Ser Pro Gln Ile Val Gly 
                485                 490                 495     


Gly Gln Met Pro Leu Gln Gln Ala Ser Pro Thr Val Leu His Leu Ser 
            500                 505                 510         


Pro Gly Gln Ser Ser Val Ser Gln Gly Arg Pro Gly Phe Ala Thr Met 
        515                 520                 525             


Pro Ala Val Ser Gly Met Ala Gly Pro Ala Arg Phe Pro Ala Val Ser 
    530                 535                 540                 


Ser Ala Ser Thr Ala His Pro Thr Leu Gly Pro Thr Val Gln Ser Gly 
545                 550                 555                 560 


Ala Pro Gly Ser Asn Phe Thr Gly Asp Gln Leu Thr Gln Ala Asn Arg 
                565                 570                 575     


Thr Pro Ala Pro Val Ser Val Ser His Arg Leu Pro Val Ser Ala Ser 
            580                 585                 590         


Lys Ser Pro Ser Thr Leu Ser Asn Thr Pro Gly Thr Gln Gln Gln Phe 
        595                 600                 605             


Phe Cys Gln Ala Gln Lys Lys Cys Leu Asn Gln Thr Ser Pro Ile Pro 
    610                 615                 620                 


Thr Ser Lys Thr Thr Asp Gly Leu Arg Pro Ser Gln Ile Pro Gly Leu 
625                 630                 635                 640 


Leu Ser Thr Ala Leu Pro Gly Gln Asp Ser Gly Ser Lys Ile Met Pro 
                645                 650                 655     


Ala Thr Leu Gly Ala Thr Gln Ala Gln Pro Glu Ser Ser Val Gly Ser 
            660                 665                 670         


Ser Pro Ser Gln Thr Ala Val Gln Val Asp Ser His Pro Gly Gln Lys 
        675                 680                 685             


Arg Pro Ala Ala Lys Gln Leu Thr Lys Gly Ala Phe Ile Leu Gln Gln 
    690                 695                 700                 


Leu Gln Arg Asp Gln Ala His Ala Val Thr Pro Asp Lys Ser Gln Phe 
705                 710                 715                 720 


Arg Ser Leu Asn Asp Thr Val Gln Arg Leu Leu Ser Tyr His Val Cys 
                725                 730                 735     


Gln Gly Ser Met Pro Thr Glu Glu Asp Leu Arg Gln Val Asp Asn Glu 
            740                 745                 750         


Phe Glu Glu Val Ala Thr Gln Leu Leu Lys Arg Thr Gln Ala Met Leu 
        755                 760                 765             


Asn Lys Tyr Arg Phe Leu Leu Leu Glu Asp Ala Met Arg Ile Asn Pro 
    770                 775                 780                 


Ser Ala Glu Met Val Met Ile Asp Arg Met Phe Asn Gln Glu Glu Arg 
785                 790                 795                 800 


Ala Ser Leu Ser Arg Asp Lys Arg Leu Ala Leu Val Asp Pro Glu Gly 
                805                 810                 815     


Phe Gln Ala Asp Phe Cys Cys Ser Phe Lys Leu Asp Glu Ala Val Pro 
            820                 825                 830         


Glu Thr Pro Leu Asp Arg Ser Asp Gln His Arg Ser Lys Thr Ser Ser 
        835                 840                 845             


Leu His Gln Val Pro Arg Ala Gln Ser Arg Asp Arg Ala Lys Pro Gly 
    850                 855                 860                 


Met Ala Glu Ala Thr Asn His Asp Gln Phe His Leu Val Pro Asn His 
865                 870                 875                 880 


Ile Val Val Ser Ala Glu Gly Asn Ile Ser Lys Lys Ser Glu Gly His 
                885                 890                 895     


Ser Arg Thr Leu Lys Phe Asp Arg Gly Val Leu Gly Gln Tyr Arg Gly 
            900                 905                 910         


Pro Pro Glu Asp Lys Gly Gly Arg Arg Asp Pro Ala Lys Val Ser Arg 
        915                 920                 925             


Cys Ser Pro Gly Pro Glu Gly His Arg Lys Ser Leu Pro Arg Pro Asp 
    930                 935                 940                 


His Gly Ser Glu Ser Lys Leu Pro Gly Val Leu Ala Ser Ser His Met 
945                 950                 955                 960 


Glu Met Pro Cys Leu Asp Ser Phe Gln Asp Lys Ala Leu Arg Asn Ser 
                965                 970                 975     


Pro Lys Asn Glu Val Leu His Thr Asp Ile Met Lys Gly Ser Gly Glu 
            980                 985                 990         


Pro Gln Pro Asp Leu Gln Leu Thr  Lys Ser Leu Glu Lys  Thr Phe Lys 
        995                 1000                 1005             


Asn Ile  Leu Glu Leu Lys Asn  Ser Gly Arg Pro Pro  Ser Asp Pro 
    1010                 1015                 1020             


Thr Ala  Ser Gly Ala Ala Asp  Leu Asp Phe Pro Ser  Phe Ser Pro 
    1025                 1030                 1035             


Met Ala  Ser Gln Glu Asn Cys  Leu Glu Lys Phe Ile  Pro Asp His 
    1040                 1045                 1050             


Ser Glu  Gly Val Val Glu Thr  Asp Ser Ile Leu Glu  Ala Ala Val 
    1055                 1060                 1065             


Asn Ser  Ile Leu Glu Cys 
    1070                 


<210>  20
<211>  2699
<212>  DNA
<213>  Homo sapiens

<400>  20
ctgccgcggc cccgcctcgc cccgtttccg gcgcggccca gcgagctcgg caacctcggc       60

gcagcgagcg cgggcggcca gccagggcca gggggcggtg gcggccaagg tccgaccggg      120

tgccagctgt tcccagcccc cgcctcgggc ccgccgccgg cgccgccatg ggcaagaagc      180

acaagaagca caaggccgag tggcgctcgt cctacgagga ttatgccgac aagcccctgg      240

agaagcctct aaagctagtc ctgaaggtcg gaggaagtga agtgactgaa ctctcaggat      300

ccggccacga ctccagttac tatgatgaca ggtcagacca tgagcgagag aggcacaaag      360

aaaagaaaaa gaagaagaag aagaagtccg agaaggagaa gcatctggac gatgaggaaa      420

gaaggaagcg aaaggaagag aagaagcgga agcgagagag ggagcactgt gacacggagg      480

gagaggctga cgactttgat cctgggaaga aggtggaggt ggagccgccc ccagatcggc      540

cagtccgagc gtgccggaca cagccagccg aaaatgagag cacacctatt cagcaactcc      600

tggaacactt cctccgccag cttcagagaa aagatcccca tggatttttt gcttttcctg      660

tcacggatgc aattgctcct ggatattcaa tgataataaa acatcccatg gattttggca      720

ccatgaaaga caaaattgta gctaatgaat acaagtcagt tacggaattt aaggcagatt      780

tcaagctgat gtgtgataat gcaatgacat acaataggcc agataccgtg tactacaagt      840

tggcgaagaa gatccttcac gcaggcttta agatgatgag caaacaggca gctcttttgg      900

gcaatgaaga tacagctgtt gaggaacctg tccctgaagt tgtaccagta caagtagaaa      960

ctgccaagaa atccaaaaag ccgagtagag aagttatcag ctgcatgttt gagcctgaag     1020

ggaatgcctg cagcttgacg gacagtaccg cagaggagca cgtgctggcg ctggtggagc     1080

acgcagctga cgaagctcgg gacaggatca accggttcct cccaggcggc aagatgggct     1140

atctgaagag gaacggggac gggagcctgc tctacagcgt ggtcaacacg gccgagccgg     1200

acgctgatga ggaggagacc cacccggtgg acttgagctc gctctccagt aagctactcc     1260

caggcttcac cacgctgggc ttcaaagacg agagaagaaa caaagtcacc tttctctcca     1320

gtgccactac tgcgctttcg atgcagaata attcagtatt tggcgacttg aagtcggacg     1380

agatggagct gctctactca gcctacggag atgagacagg cgtgcagtgt gcgctgagcc     1440

tgcaggagtt tgtgaaggat gctgggagct acagcaagaa agtggtggac gacctcctgg     1500

accagatcac aggcggagac cactctagga cgctcttcca gctgaagcag agaagaaatg     1560

ttcccatgaa gcctccagat gaagccaagg ttggggacac cctaggagac agcagcagct     1620

ctgttctgga gttcatgtcg atgaagtcct atcccgacgt ttctgtggat atctccatgc     1680

tcagctctct ggggaaggtg aagaaggagc tggaccctga cgacagccat ttgaacttgg     1740

atgagacgac gaagctcctg caggacctgc acgaagcaca ggcggagcgc ggcggctctc     1800

ggccgtcgtc caacctcagc tccctgtcca acgcctccga gagggaccag caccacctgg     1860

gaagcccttc tcgcctgagt gtcggggagc agccagacgt cacccacgac ccctatgagt     1920

ttcttcagtc tccagagcct gcggcctctg ccaagaccta actctagacc accttcagct     1980

cttttatttt atttttttag ttttattttg cacgtgtaga gtttttgtca tcagacaagg     2040

actttgatcc tgtccccttt ggcatgcggg aagcagccgc ggggaggtaa tgaattgtct     2100

gtggtatcat gtcagcagag tctccaagcc ccacgaaccc tgaggagtgg agtcatacgc     2160

gaaggccata tggccatcgt gtcagcagag agagtctctg tacacagccc cgtgaaccct     2220

gaggagtgga gtcatacacg aagggcgtgt ggccatcgtg tcagcagaga gagtctctgt     2280

acacagcccc gtgaaccctg aggagtggag tcatacgcga agggtgtgtg gccaggctgc     2340

agagctgcgt gccgtttgtg tccgagcatc acgtgtggct ccagcccttg tttctgccag     2400

tgtagacacc tctgtctgcc ccactgtcct ggggtcgctc ttgggaggca caggcatggg     2460

tgtgtctggc ctcattctgt atcagtccag tgtgttcctg tcatagtttg tgtctcccag     2520

gcaggccatg gtaggggcct cgcaggggcc attggggagc acagggccag gctggggtga     2580

ggagagctcc cctgttttct gtttaattga tgagcctggg aaaggagtgt gttctgcctg     2640

cccgttacag tggagcgttc cgtgtccata aaacgttttc taactgggtg tttaaaaaa      2699


<210>  21
<211>  597
<212>  PRT
<213>  Homo sapiens

<400>  21

Met Gly Lys Lys His Lys Lys His Lys Ala Glu Trp Arg Ser Ser Tyr 
1               5                   10                  15      


Glu Asp Tyr Ala Asp Lys Pro Leu Glu Lys Pro Leu Lys Leu Val Leu 
            20                  25                  30          


Lys Val Gly Gly Ser Glu Val Thr Glu Leu Ser Gly Ser Gly His Asp 
        35                  40                  45              


Ser Ser Tyr Tyr Asp Asp Arg Ser Asp His Glu Arg Glu Arg His Lys 
    50                  55                  60                  


Glu Lys Lys Lys Lys Lys Lys Lys Lys Ser Glu Lys Glu Lys His Leu 
65                  70                  75                  80  


Asp Asp Glu Glu Arg Arg Lys Arg Lys Glu Glu Lys Lys Arg Lys Arg 
                85                  90                  95      


Glu Arg Glu His Cys Asp Thr Glu Gly Glu Ala Asp Asp Phe Asp Pro 
            100                 105                 110         


Gly Lys Lys Val Glu Val Glu Pro Pro Pro Asp Arg Pro Val Arg Ala 
        115                 120                 125             


Cys Arg Thr Gln Pro Ala Glu Asn Glu Ser Thr Pro Ile Gln Gln Leu 
    130                 135                 140                 


Leu Glu His Phe Leu Arg Gln Leu Gln Arg Lys Asp Pro His Gly Phe 
145                 150                 155                 160 


Phe Ala Phe Pro Val Thr Asp Ala Ile Ala Pro Gly Tyr Ser Met Ile 
                165                 170                 175     


Ile Lys His Pro Met Asp Phe Gly Thr Met Lys Asp Lys Ile Val Ala 
            180                 185                 190         


Asn Glu Tyr Lys Ser Val Thr Glu Phe Lys Ala Asp Phe Lys Leu Met 
        195                 200                 205             


Cys Asp Asn Ala Met Thr Tyr Asn Arg Pro Asp Thr Val Tyr Tyr Lys 
    210                 215                 220                 


Leu Ala Lys Lys Ile Leu His Ala Gly Phe Lys Met Met Ser Lys Gln 
225                 230                 235                 240 


Ala Ala Leu Leu Gly Asn Glu Asp Thr Ala Val Glu Glu Pro Val Pro 
                245                 250                 255     


Glu Val Val Pro Val Gln Val Glu Thr Ala Lys Lys Ser Lys Lys Pro 
            260                 265                 270         


Ser Arg Glu Val Ile Ser Cys Met Phe Glu Pro Glu Gly Asn Ala Cys 
        275                 280                 285             


Ser Leu Thr Asp Ser Thr Ala Glu Glu His Val Leu Ala Leu Val Glu 
    290                 295                 300                 


His Ala Ala Asp Glu Ala Arg Asp Arg Ile Asn Arg Phe Leu Pro Gly 
305                 310                 315                 320 


Gly Lys Met Gly Tyr Leu Lys Arg Asn Gly Asp Gly Ser Leu Leu Tyr 
                325                 330                 335     


Ser Val Val Asn Thr Ala Glu Pro Asp Ala Asp Glu Glu Glu Thr His 
            340                 345                 350         


Pro Val Asp Leu Ser Ser Leu Ser Ser Lys Leu Leu Pro Gly Phe Thr 
        355                 360                 365             


Thr Leu Gly Phe Lys Asp Glu Arg Arg Asn Lys Val Thr Phe Leu Ser 
    370                 375                 380                 


Ser Ala Thr Thr Ala Leu Ser Met Gln Asn Asn Ser Val Phe Gly Asp 
385                 390                 395                 400 


Leu Lys Ser Asp Glu Met Glu Leu Leu Tyr Ser Ala Tyr Gly Asp Glu 
                405                 410                 415     


Thr Gly Val Gln Cys Ala Leu Ser Leu Gln Glu Phe Val Lys Asp Ala 
            420                 425                 430         


Gly Ser Tyr Ser Lys Lys Val Val Asp Asp Leu Leu Asp Gln Ile Thr 
        435                 440                 445             


Gly Gly Asp His Ser Arg Thr Leu Phe Gln Leu Lys Gln Arg Arg Asn 
    450                 455                 460                 


Val Pro Met Lys Pro Pro Asp Glu Ala Lys Val Gly Asp Thr Leu Gly 
465                 470                 475                 480 


Asp Ser Ser Ser Ser Val Leu Glu Phe Met Ser Met Lys Ser Tyr Pro 
                485                 490                 495     


Asp Val Ser Val Asp Ile Ser Met Leu Ser Ser Leu Gly Lys Val Lys 
            500                 505                 510         


Lys Glu Leu Asp Pro Asp Asp Ser His Leu Asn Leu Asp Glu Thr Thr 
        515                 520                 525             


Lys Leu Leu Gln Asp Leu His Glu Ala Gln Ala Glu Arg Gly Gly Ser 
    530                 535                 540                 


Arg Pro Ser Ser Asn Leu Ser Ser Leu Ser Asn Ala Ser Glu Arg Asp 
545                 550                 555                 560 


Gln His His Leu Gly Ser Pro Ser Arg Leu Ser Val Gly Glu Gln Pro 
                565                 570                 575     


Asp Val Thr His Asp Pro Tyr Glu Phe Leu Gln Ser Pro Glu Pro Ala 
            580                 585                 590         


Ala Ser Ala Lys Thr 
        595         


<210>  22
<211>  2526
<212>  DNA
<213>  Homo sapiens

<400>  22
acgggggagg agttccgggc acgcggacgg gggtcctggg caccgggcga gattatgccg       60

acaagcccct ggagaagcct ctaaagctag tcctgaaggt cggaggaagt gaagtgactg      120

aactctcagg atccggccac gactccagtt actatgatga caggtcagac catgagcgag      180

agaggcacaa agaaaagaaa aagaagaaga agaagaagtc cgagaaggag aagcatctgg      240

acgatgagga aagaaggaag cgaaaggaag agaagaagcg gaagcgagag agggagcact      300

gtgacacgga gggagaggct gacgactttg atcctgggaa gaaggtggag gtggagccgc      360

ccccagatcg gccagtccga gcgtgccgga cacagccagc cgaaaatgag agcacaccta      420

ttcagcaact cctggaacac ttcctccgcc agcttcagag atccccatgg attttttgct      480

tttcctgtca cggatgcaat tgctcctgga tattcaatga taataaaaca tcccatggat      540

tttggcacca tgaaagacaa aattgtagct aatgaataca agtcagttac ggaatttaag      600

gcagatttca agctgatgtg tgataatgca atgacataca ataggccaga taccgtgtac      660

tacaagttgg cgaagaagat ccttcacgca ggctttaaga tgatgagcaa acaggcagct      720

cttttgggca atgaagatac agctgttgag gaacctgtcc ctgaagttgt accagtacaa      780

gtagaaactg ccaagaaatc caaaaagccg agtagagaag ttatcagctg catgtttgag      840

cctgaaggga atgcctgcag cttgacggac agtaccgcag aggagcacgt gctggcgctg      900

gtggagcacg cagctgacga agctcgggac aggatcaacc ggttcctccc aggcggcaag      960

atgggctatc tgaagaggaa cggggacggg agcctgctct acagcgtggt caacacggcc     1020

gagccggacg ctgatgagga ggagacccac ccggtggact tgagctcgct ctccagtaag     1080

ctactcccag gcttcaccac gctgggcttc aaagacgaga gaagaaacaa agtcaccttt     1140

ctctccagtg ccactactgc gctttcgatg cagaataatt cagtatttgg cgacttgaag     1200

tcggacgaga tggagctgct ctactcagcc tacggagatg agacaggcgt gcagtgtgcg     1260

ctgagcctgc aggagtttgt gaaggatgct gggagctaca gcaagaaagt ggtggacgac     1320

ctcctggacc agatcacagg cggagaccac tctaggacgc tcttccagct gaagcagaga     1380

agaaatgttc ccatgaagcc tccagatgaa gccaaggttg gggacaccct aggagacagc     1440

agcagctctg ttctggagtt catgtcgatg aagtcctatc ccgacgtttc tgtggatatc     1500

tccatgctca gctctctggg gaaggtgaag aaggagctgg accctgacga cagccatttg     1560

aacttggatg agacgacgaa gctcctgcag gacctgcacg aagcacaggc ggagcgcggc     1620

ggctctcggc cgtcgtccaa cctcagctcc ctgtccaacg cctccgagag ggaccagcac     1680

cacctgggaa gcccttctcg cctgagtgtc ggggagcagc cagacgtcac ccacgacccc     1740

tatgagtttc ttcagtctcc agagcctgcg gcctctgcca agacctaact ctagaccacc     1800

ttcagctctt ttattttatt tttttagttt tattttgcac gtgtagagtt tttgtcatca     1860

gacaaggact ttgatcctgt cccctttggc atgcgggaag cagccgcggg gaggtaatga     1920

attgtctgtg gtatcatgtc agcagagtct ccaagcccca cgaaccctga ggagtggagt     1980

catacgcgaa ggccatatgg ccatcgtgtc agcagagaga gtctctgtac acagccccgt     2040

gaaccctgag gagtggagtc atacacgaag ggcgtgtggc catcgtgtca gcagagagag     2100

tctctgtaca cagccccgtg aaccctgagg agtggagtca tacgcgaagg gtgtgtggcc     2160

aggctgcaga gctgcgtgcc gtttgtgtcc gagcatcacg tgtggctcca gcccttgttt     2220

ctgccagtgt agacacctct gtctgcccca ctgtcctggg gtcgctcttg ggaggcacag     2280

gcatgggtgt gtctggcctc attctgtatc agtccagtgt gttcctgtca tagtttgtgt     2340

ctcccaggca ggccatggta ggggcctcgc aggggccatt ggggagcaca gggccaggct     2400

ggggtgagga gagctcccct gttttctgtt taattgatga gcctgggaaa ggagtgtgtt     2460

ctgcctgccc gttacagtgg agcgttccgt gtccataaaa cgttttctaa ctgggtgttt     2520

aaaaaa                                                                2526


<210>  23
<211>  544
<212>  PRT
<213>  Homo sapiens

<400>  23

Met Met Thr Gly Gln Thr Met Ser Glu Arg Gly Thr Lys Lys Arg Lys 
1               5                   10                  15      


Arg Arg Arg Arg Arg Ser Pro Arg Arg Arg Ser Ile Trp Thr Met Arg 
            20                  25                  30          


Lys Glu Gly Ser Glu Arg Lys Arg Arg Ser Gly Ser Glu Arg Gly Ser 
        35                  40                  45              


Thr Val Thr Arg Arg Glu Arg Leu Thr Thr Leu Ile Leu Gly Arg Arg 
    50                  55                  60                  


Trp Arg Trp Ser Arg Pro Gln Ile Gly Gln Ser Glu Arg Ala Gly His 
65                  70                  75                  80  


Ser Gln Pro Lys Met Arg Ala His Leu Phe Ser Asn Ser Trp Asn Thr 
                85                  90                  95      


Ser Ser Ala Ser Phe Arg Asp Pro His Gly Phe Phe Ala Phe Pro Val 
            100                 105                 110         


Thr Asp Ala Ile Ala Pro Gly Tyr Ser Met Ile Ile Lys His Pro Met 
        115                 120                 125             


Asp Phe Gly Thr Met Lys Asp Lys Ile Val Ala Asn Glu Tyr Lys Ser 
    130                 135                 140                 


Val Thr Glu Phe Lys Ala Asp Phe Lys Leu Met Cys Asp Asn Ala Met 
145                 150                 155                 160 


Thr Tyr Asn Arg Pro Asp Thr Val Tyr Tyr Lys Leu Ala Lys Lys Ile 
                165                 170                 175     


Leu His Ala Gly Phe Lys Met Met Ser Lys Gln Ala Ala Leu Leu Gly 
            180                 185                 190         


Asn Glu Asp Thr Ala Val Glu Glu Pro Val Pro Glu Val Val Pro Val 
        195                 200                 205             


Gln Val Glu Thr Ala Lys Lys Ser Lys Lys Pro Ser Arg Glu Val Ile 
    210                 215                 220                 


Ser Cys Met Phe Glu Pro Glu Gly Asn Ala Cys Ser Leu Thr Asp Ser 
225                 230                 235                 240 


Thr Ala Glu Glu His Val Leu Ala Leu Val Glu His Ala Ala Asp Glu 
                245                 250                 255     


Ala Arg Asp Arg Ile Asn Arg Phe Leu Pro Gly Gly Lys Met Gly Tyr 
            260                 265                 270         


Leu Lys Arg Asn Gly Asp Gly Ser Leu Leu Tyr Ser Val Val Asn Thr 
        275                 280                 285             


Ala Glu Pro Asp Ala Asp Glu Glu Glu Thr His Pro Val Asp Leu Ser 
    290                 295                 300                 


Ser Leu Ser Ser Lys Leu Leu Pro Gly Phe Thr Thr Leu Gly Phe Lys 
305                 310                 315                 320 


Asp Glu Arg Arg Asn Lys Val Thr Phe Leu Ser Ser Ala Thr Thr Ala 
                325                 330                 335     


Leu Ser Met Gln Asn Asn Ser Val Phe Gly Asp Leu Lys Ser Asp Glu 
            340                 345                 350         


Met Glu Leu Leu Tyr Ser Ala Tyr Gly Asp Glu Thr Gly Val Gln Cys 
        355                 360                 365             


Ala Leu Ser Leu Gln Glu Phe Val Lys Asp Ala Gly Ser Tyr Ser Lys 
    370                 375                 380                 


Lys Val Val Asp Asp Leu Leu Asp Gln Ile Thr Gly Gly Asp His Ser 
385                 390                 395                 400 


Arg Thr Leu Phe Gln Leu Lys Gln Arg Arg Asn Val Pro Met Lys Pro 
                405                 410                 415     


Pro Asp Glu Ala Lys Val Gly Asp Thr Leu Gly Asp Ser Ser Ser Ser 
            420                 425                 430         


Val Leu Glu Phe Met Ser Met Lys Ser Tyr Pro Asp Val Ser Val Asp 
        435                 440                 445             


Ile Ser Met Leu Ser Ser Leu Gly Lys Val Lys Lys Glu Leu Asp Pro 
    450                 455                 460                 


Asp Asp Ser His Leu Asn Leu Asp Glu Thr Thr Lys Leu Leu Gln Asp 
465                 470                 475                 480 


Leu His Glu Ala Gln Ala Glu Arg Gly Gly Ser Arg Pro Ser Ser Asn 
                485                 490                 495     


Leu Ser Ser Leu Ser Asn Ala Ser Glu Arg Asp Gln His His Leu Gly 
            500                 505                 510         


Ser Pro Ser Arg Leu Ser Val Gly Glu Gln Pro Asp Val Thr His Asp 
        515                 520                 525             


Pro Tyr Glu Phe Leu Gln Ser Pro Glu Pro Ala Ala Ser Ala Lys Thr 
    530                 535                 540                 


<210>  24
<211>  2878
<212>  DNA
<213>  Homo sapiens

<400>  24
ctgccgcggc cccgcctcgc cccgtttccg gcgcggccca gcgagctcgg caacctcggc       60

gcagcgagcg cgggcggcca gccagggcca gggggcggtg gcggccaagg tccgaccggg      120

tgccagctgt tcccagcccc cgcctcgggc ccgccgccgg cgccgccatg ggcaagaagc      180

acaagaagca caaggccgag tggcgctcgt cctacgagga ttatgccgac aagcccctgg      240

agaagcctct aaagctagtc ctgaaggtcg gaggaagtga agtgactgaa ctctcaggat      300

ccggccacga ctccagttac tatgatgaca ggtcagacca tgagcgagag aggcacaaag      360

aaaagaaaaa gaagaagaag aagaagtccg agaaggagaa gcatctggac gatgaggaaa      420

gaaggaagcg aaaggaagag aagaagcgga agcgagagag ggagcactgt gacacggagg      480

gagaggctga cgactttgat cctgggaaga aggtggaggt ggagccgccc ccagatcggc      540

cagtccgagc gtgccggaca cagccagttc tcggtggaac ttaaaatgct gtgagacacc      600

agacagacag atactgtgaa cttggagctc tctaatgaag ggataccaaa gtcttgtatt      660

caattttttt ttccttaaat tgtcagccga aaatgagagc acacctattc agcaactcct      720

ggaacacttc ctccgccagc ttcagagaaa agatccccat ggattttttg cttttcctgt      780

cacggatgca attgctcctg gatattcaat gataataaaa catcccatgg attttggcac      840

catgaaagac aaaattgtag ctaatgaata caagtcagtt acggaattta aggcagattt      900

caagctgatg tgtgataatg caatgacata caataggcca gataccgtgt actacaagtt      960

ggcgaagaag atccttcacg caggctttaa gatgatgagc aaagagcggc tgttagcttt     1020

gaagcgcagc atgtcgttta tgcaggacat ggatttttct cagcaggcag ctcttttggg     1080

caatgaagat acagctgttg aggaacctgt ccctgaagtt gtaccagtac aagtagaaac     1140

tgccaagaaa tccaaaaagc cgagtagaga agttatcagc tgcatgtttg agcctgaagg     1200

gaatgcctgc agcttgacgg acagtaccgc agaggagcac gtgctggcgc tggtggagca     1260

cgcagctgac gaagctcggg acaggatcaa ccggttcctc ccaggcggca agatgggcta     1320

tctgaagagg aacggggacg ggagcctgct ctacagcgtg gtcaacacgg ccgagccgga     1380

cgctgatgag gaggagaccc acccggtgga cttgagctcg ctctccagta agctactccc     1440

aggcttcacc acgctgggct tcaaagacga gagaagaaac aaagtcacct ttctctccag     1500

tgccactact gcgctttcga tgcagaataa ttcagtattt ggcgacttga agtcggacga     1560

gatggagctg ctctactcag cctacggaga tgagacaggc gtgcagtgtg cgctgagcct     1620

gcaggagttt gtgaaggatg ctgggagcta cagcaagaaa gtggtggacg acctcctgga     1680

ccagatcaca ggcggagacc actctaggac gctcttccag ctgaagcaga gaagaaatgt     1740

tcccatgaag cctccagatg aagccaaggt tggggacacc ctaggagaca gcagcagctc     1800

tgttctggag ttcatgtcga tgaagtccta tcccgacgtt tctgtggata tctccatgct     1860

cagctctctg gggaaggtga agaaggagct ggaccctgac gacagccatt tgaacttgga     1920

tgagacgacg aagctcctgc aggacctgca cgaagcacag gcggagcgcg gcggctctcg     1980

gccgtcgtcc aacctcagct ccctgtccaa cgcctccgag agggaccagc accacctggg     2040

aagcccttct cgcctgagtg tcggggagca gccagacgtc acccacgacc cctatgagtt     2100

tcttcagtct ccagagcctg cggcctctgc caagacctaa ctctagacca ccttcagctc     2160

ttttatttta tttttttagt tttattttgc acgtgtagag tttttgtcat cagacaagga     2220

ctttgatcct gtcccctttg gcatgcggga agcagccgcg gggaggtaat gaattgtctg     2280

tggtatcatg tcagcagagt ctccaagccc cacgaaccct gaggagtgga gtcatacgcg     2340

aaggccatat ggccatcgtg tcagcagaga gagtctctgt acacagcccc gtgaaccctg     2400

aggagtggag tcatacacga agggcgtgtg gccatcgtgt cagcagagag agtctctgta     2460

cacagccccg tgaaccctga ggagtggagt catacgcgaa gggtgtgtgg ccaggctgca     2520

gagctgcgtg ccgtttgtgt ccgagcatca cgtgtggctc cagcccttgt ttctgccagt     2580

gtagacacct ctgtctgccc cactgtcctg gggtcgctct tgggaggcac aggcatgggt     2640

gtgtctggcc tcattctgta tcagtccagt gtgttcctgt catagtttgt gtctcccagg     2700

caggccatgg taggggcctc gcaggggcca ttggggagca cagggccagg ctggggtgag     2760

gagagctccc ctgttttctg tttaattgat gagcctggga aaggagtgtg ttctgcctgc     2820

ccgttacagt ggagcgttcc gtgtccataa aacgttttct aactgggtgt ttaaaaaa       2878


<210>  25
<211>  501
<212>  PRT
<213>  Homo sapiens

<400>  25

Met Lys Gly Tyr Gln Ser Leu Val Phe Asn Phe Phe Phe Leu Lys Leu 
1               5                   10                  15      


Ser Ala Glu Asn Glu Ser Thr Pro Ile Gln Gln Leu Leu Glu His Phe 
            20                  25                  30          


Leu Arg Gln Leu Gln Arg Lys Asp Pro His Gly Phe Phe Ala Phe Pro 
        35                  40                  45              


Val Thr Asp Ala Ile Ala Pro Gly Tyr Ser Met Ile Ile Lys His Pro 
    50                  55                  60                  


Met Asp Phe Gly Thr Met Lys Asp Lys Ile Val Ala Asn Glu Tyr Lys 
65                  70                  75                  80  


Ser Val Thr Glu Phe Lys Ala Asp Phe Lys Leu Met Cys Asp Asn Ala 
                85                  90                  95      


Met Thr Tyr Asn Arg Pro Asp Thr Val Tyr Tyr Lys Leu Ala Lys Lys 
            100                 105                 110         


Ile Leu His Ala Gly Phe Lys Met Met Ser Lys Glu Arg Leu Leu Ala 
        115                 120                 125             


Leu Lys Arg Ser Met Ser Phe Met Gln Asp Met Asp Phe Ser Gln Gln 
    130                 135                 140                 


Ala Ala Leu Leu Gly Asn Glu Asp Thr Ala Val Glu Glu Pro Val Pro 
145                 150                 155                 160 


Glu Val Val Pro Val Gln Val Glu Thr Ala Lys Lys Ser Lys Lys Pro 
                165                 170                 175     


Ser Arg Glu Val Ile Ser Cys Met Phe Glu Pro Glu Gly Asn Ala Cys 
            180                 185                 190         


Ser Leu Thr Asp Ser Thr Ala Glu Glu His Val Leu Ala Leu Val Glu 
        195                 200                 205             


His Ala Ala Asp Glu Ala Arg Asp Arg Ile Asn Arg Phe Leu Pro Gly 
    210                 215                 220                 


Gly Lys Met Gly Tyr Leu Lys Arg Asn Gly Asp Gly Ser Leu Leu Tyr 
225                 230                 235                 240 


Ser Val Val Asn Thr Ala Glu Pro Asp Ala Asp Glu Glu Glu Thr His 
                245                 250                 255     


Pro Val Asp Leu Ser Ser Leu Ser Ser Lys Leu Leu Pro Gly Phe Thr 
            260                 265                 270         


Thr Leu Gly Phe Lys Asp Glu Arg Arg Asn Lys Val Thr Phe Leu Ser 
        275                 280                 285             


Ser Ala Thr Thr Ala Leu Ser Met Gln Asn Asn Ser Val Phe Gly Asp 
    290                 295                 300                 


Leu Lys Ser Asp Glu Met Glu Leu Leu Tyr Ser Ala Tyr Gly Asp Glu 
305                 310                 315                 320 


Thr Gly Val Gln Cys Ala Leu Ser Leu Gln Glu Phe Val Lys Asp Ala 
                325                 330                 335     


Gly Ser Tyr Ser Lys Lys Val Val Asp Asp Leu Leu Asp Gln Ile Thr 
            340                 345                 350         


Gly Gly Asp His Ser Arg Thr Leu Phe Gln Leu Lys Gln Arg Arg Asn 
        355                 360                 365             


Val Pro Met Lys Pro Pro Asp Glu Ala Lys Val Gly Asp Thr Leu Gly 
    370                 375                 380                 


Asp Ser Ser Ser Ser Val Leu Glu Phe Met Ser Met Lys Ser Tyr Pro 
385                 390                 395                 400 


Asp Val Ser Val Asp Ile Ser Met Leu Ser Ser Leu Gly Lys Val Lys 
                405                 410                 415     


Lys Glu Leu Asp Pro Asp Asp Ser His Leu Asn Leu Asp Glu Thr Thr 
            420                 425                 430         


Lys Leu Leu Gln Asp Leu His Glu Ala Gln Ala Glu Arg Gly Gly Ser 
        435                 440                 445             


Arg Pro Ser Ser Asn Leu Ser Ser Leu Ser Asn Ala Ser Glu Arg Asp 
    450                 455                 460                 


Gln His His Leu Gly Ser Pro Ser Arg Leu Ser Val Gly Glu Gln Pro 
465                 470                 475                 480 


Asp Val Thr His Asp Pro Tyr Glu Phe Leu Gln Ser Pro Glu Pro Ala 
                485                 490                 495     


Ala Ser Ala Lys Thr 
            500     


<210>  26
<211>  597
<212>  PRT
<213>  Mus musculus

<400>  26

Met Gly Lys Lys His Lys Lys His Lys Ala Glu Trp Arg Ser Ser Tyr 
1               5                   10                  15      


Glu Asp Tyr Thr Asp Thr Pro Leu Glu Lys Pro Leu Lys Leu Val Leu 
            20                  25                  30          


Lys Val Gly Gly Ser Glu Val Thr Glu Leu Ser Gly Ser Gly His Asp 
        35                  40                  45              


Ser Ser Tyr Tyr Asp Asp Arg Ser Asp His Glu Arg Glu Arg His Arg 
    50                  55                  60                  


Glu Lys Lys Lys Lys Lys Lys Lys Lys Ser Glu Lys Glu Lys His Leu 
65                  70                  75                  80  


Asp Glu Glu Glu Arg Arg Lys Arg Lys Glu Glu Lys Lys Arg Lys Arg 
                85                  90                  95      


Glu Lys Glu His Cys Asp Ser Glu Gly Glu Ala Asp Ala Phe Asp Pro 
            100                 105                 110         


Gly Lys Lys Val Glu Val Glu Pro Pro Pro Asp Arg Pro Val Arg Ala 
        115                 120                 125             


Cys Arg Thr Gln Pro Ala Glu Asn Glu Ser Thr Pro Ile Gln Arg Leu 
    130                 135                 140                 


Leu Glu His Phe Leu Arg Gln Leu Gln Arg Lys Asp Pro His Gly Phe 
145                 150                 155                 160 


Phe Ala Phe Pro Val Thr Asp Ala Ile Ala Pro Gly Tyr Ser Met Ile 
                165                 170                 175     


Ile Lys His Pro Met Asp Phe Gly Thr Met Lys Asp Lys Ile Val Ala 
            180                 185                 190         


Asn Glu Tyr Lys Ser Val Thr Glu Phe Lys Ala Asp Phe Lys Leu Met 
        195                 200                 205             


Cys Asp Asn Ala Met Thr Tyr Asn Arg Pro Asp Thr Val Tyr Tyr Lys 
    210                 215                 220                 


Leu Ala Lys Lys Ile Leu His Ala Gly Phe Lys Met Met Ser Lys Gln 
225                 230                 235                 240 


Ala Ala Leu Leu Gly Ser Glu Asp Pro Ala Ala Glu Glu Pro Val Pro 
                245                 250                 255     


Glu Val Val Pro Val Gln Val Glu Thr Thr Lys Lys Ser Lys Lys Pro 
            260                 265                 270         


Ser Arg Glu Val Ile Ser Cys Met Phe Glu Pro Glu Gly Asn Ala Cys 
        275                 280                 285             


Ser Leu Thr Asp Ser Thr Ala Glu Glu His Val Leu Ala Leu Val Glu 
    290                 295                 300                 


His Ala Ala Asp Glu Ala Arg Asp Arg Ile Asn Arg Phe Leu Pro Gly 
305                 310                 315                 320 


Gly Lys Met Gly Tyr Leu Lys Lys Leu Gly Asp Gly Ser Leu Leu Tyr 
                325                 330                 335     


Ser Val Val Asn Ala Pro Glu Pro Asp Ala Asp Glu Glu Glu Thr His 
            340                 345                 350         


Pro Val Asp Leu Ser Ser Leu Ser Ser Lys Leu Leu Pro Gly Phe Thr 
        355                 360                 365             


Thr Leu Gly Phe Lys Asp Glu Arg Arg Asn Lys Val Thr Phe Leu Ser 
    370                 375                 380                 


Ser Ala Ser Thr Ala Leu Ser Met Gln Asn Asn Ser Val Phe Gly Asp 
385                 390                 395                 400 


Leu Lys Ser Asp Glu Met Glu Leu Leu Tyr Ser Ala Tyr Gly Asp Glu 
                405                 410                 415     


Thr Gly Val Gln Cys Ala Leu Ser Leu Gln Glu Phe Val Lys Asp Ala 
            420                 425                 430         


Gly Ser Tyr Ser Lys Lys Met Val Asp Asp Leu Leu Asp Gln Ile Thr 
        435                 440                 445             


Gly Gly Asp His Ser Arg Met Ile Phe Gln Leu Lys Gln Arg Arg Ser 
    450                 455                 460                 


Ile Pro Met Arg Pro Ala Asp Glu Met Lys Val Gly Asp Pro Leu Gly 
465                 470                 475                 480 


Glu Ser Gly Gly Pro Val Leu Asp Phe Met Ser Met Lys Gln Tyr Pro 
                485                 490                 495     


Asp Val Ser Leu Asp Val Ser Met Leu Ser Ser Leu Gly Lys Val Lys 
            500                 505                 510         


Lys Glu Leu Asp His Glu Asp Ser His Leu Asn Leu Asp Glu Thr Ala 
        515                 520                 525             


Arg Leu Leu Gln Asp Leu His Glu Ala Gln Ala Glu Arg Gly Gly Ser 
    530                 535                 540                 


Arg Pro Ser Ser Asn Leu Ser Ser Leu Ser Thr Ala Ser Glu Arg Glu 
545                 550                 555                 560 


His Pro Pro Pro Gly Ser Pro Ser Arg Leu Ser Val Gly Glu Gln Pro 
                565                 570                 575     


Asp Val Ala His Asp Pro Tyr Glu Phe Leu Gln Ser Pro Glu Pro Ala 
            580                 585                 590         


Ala Pro Ala Lys Asn 
        595         


<210>  27
<211>  2448
<212>  DNA
<213>  Mus musculus

<400>  27
gcggtggcga aggcgctact tccgactggc gcaggtcgag ctaccggcag ccgcttctca       60

ccggatcccg tgctatctca gccatgggca aaaagcacaa gaagcacaag gcggaatggc      120

gctcgtccta cgaagattat acagacacgc cactggagaa gcctctgaag ctggtgctca      180

aggtgggagg aagtgaagtg acagagctct caggatctgg ccacgactcc agctactacg      240

acgatcgctc agaccacgaa cgggagagac acagagaaaa gaagaaaaag aagaagaaaa      300

agtcagagaa ggagaagcac ctcgatgagg aggagaggag gaagcggaag gaagagaaga      360

aacggaaacg ggagaaggaa cactgcgact cagaggggga ggctgatgct ttcgaccctg      420

gaaagaaggt ggaggtggag ccacccccag accgaccagt gagagcctgc cgaacacagc      480

cagctgagaa cgagagcaca cctatccaga ggcttctgga acacttcctc cgccagctac      540

agagaaaaga tcctcatgga ttttttgctt ttcctgttac ggatgcaatt gctcctgggt      600

attcaatgat aataaaacat cctatggact ttggcacgat gaaagacaag attgtagcta      660

atgaatataa atcagtcaca gaatttaagg cagatttcaa attaatgtgt gataatgcga      720

tgacgtacaa tagaccagac accgtgtact acaaattagc caagaagatc ctgcacgcgg      780

gctttaagat gatgagcaaa caggcagctc tcttgggcag tgaagaccca gcagctgagg      840

aacctgttcc cgaggttgtc ccagtgcaag tagaaactac caagaaatcc aaaaagccga      900

gtagagaagt tatcagctgc atgtttgagc ctgaagggaa tgcctgcagc ctgacagaca      960

gcacggcaga ggagcatgtg ctagccctgg tagagcacgc agctgatgag gctcgggaca     1020

ggattaaccg gtttctcccg ggtggcaaga tggggtacct gaagaagctt ggagatggaa     1080

gtctgctcta cagcgtggtg aacgcacctg agcctgatgc tgatgaggag gagacacacc     1140

ctgtggacct gagttcactg tctagcaagt tgctcccagg ttttacaaca ttgggtttca     1200

aagatgaaag aagaaataaa gtcacattcc tctccagtgc cagcactgca ctttcaatgc     1260

agaacaactc tgtgtttggg gacctgaagt cagatgagat ggagcttctg tattccgcct     1320

atggagatga gactggtgtg cagtgtgcac tgagcctgca ggaattcgtg aaggatgctg     1380

gaagctatag caagaagatg gtagatgacc tcctggacca aatcacaggt ggtgatcact     1440

caaggatgat cttccagctg aagcagagga ggagcatccc catgagacct gcagatgaga     1500

tgaaggttgg ggatccactg ggagagagtg gtggccctgt tctggacttc atgtcaatga     1560

aacagtatcc tgatgtctcc ctggatgtgt ccatgctcag ctctctcggg aaagtaaaga     1620

aggagctgga ccatgaagat agccacttga acttggatga gacagccagg ctcctgcagg     1680

acttacacga agcacaagca gagcgaggag gctctcggcc atcctccaac cttagctctc     1740

tgtccactgc ctctgagagg gagcatcctc ctccaggaag tccttctcgc cttagtgttg     1800

gggagcagcc ggatgtcgcc cacgaccctt atgaattcct tcagtctcca gaacctgcag     1860

ctcctgccaa gaactaactt gtggtgttcc cagatggttt attttatttt tctacatttt     1920

atttgataca gtttttgtca caagacagaa acttttgtct catcctctct ggcaagtagc     1980

agcctgagga agatgctggc ttgtctgtac cgtcacgtct gcagcagagg cccagtagca     2040

ccgaatggtg tccaataagc tctgagcagt ggcaatagaa tgtcaacgga ttgcaatcag     2100

atggctcaac tctgtgtctc ctgagcacca gcagccaagc ctgttcatga tgatgtgcac     2160

acagtcattc tacaggagct ttgcacagcc ttcctgcagt tctcaaaggg gagcctgcag     2220

actaggcctt cagagggttc cttctgtttc ctatttgggc actgagccag aggatggagt     2280

tgtctccctg acaaataatg aaccacccca ccttttagaa tgaagtataa atgaagtcat     2340

aaaatgtttc aatgttttgc tgagtacctg tttgtattta taaaaaacat gaacacaggt     2400

cctaataaag agatgcctaa ggcggtaaaa aaaaaaaaaa aaaaaaaa                  2448


<210>  28
<211>  596
<212>  PRT
<213>  Mus musculus

<400>  28

Met Gly Lys Lys His Lys Lys His Lys Ala Glu Trp Arg Ser Ser Tyr 
1               5                   10                  15      


Glu Asp Tyr Thr Asp Thr Pro Leu Glu Lys Pro Leu Lys Leu Val Leu 
            20                  25                  30          


Lys Val Gly Gly Ser Glu Val Thr Glu Leu Ser Gly Ser Gly His Asp 
        35                  40                  45              


Ser Ser Tyr Tyr Asp Asp Arg Ser Asp His Glu Arg Glu Arg His Arg 
    50                  55                  60                  


Glu Lys Lys Lys Lys Lys Lys Lys Lys Ser Glu Lys Glu Lys His Leu 
65                  70                  75                  80  


Asp Glu Glu Glu Arg Arg Lys Arg Lys Glu Glu Lys Lys Arg Lys Arg 
                85                  90                  95      


Glu Lys Glu His Cys Asp Ser Glu Gly Glu Ala Asp Ala Phe Asp Pro 
            100                 105                 110         


Gly Lys Lys Val Glu Val Glu Pro Pro Pro Asp Arg Pro Val Arg Ala 
        115                 120                 125             


Cys Arg Thr Gln Pro Ala Glu Asn Glu Ser Thr Pro Ile Gln Arg Leu 
    130                 135                 140                 


Leu Glu His Phe Leu Arg Gln Leu Gln Arg Lys Asp Pro His Gly Phe 
145                 150                 155                 160 


Phe Ala Phe Pro Val Thr Asp Ala Ile Ala Pro Gly Tyr Ser Met Ile 
                165                 170                 175     


Ile Lys His Pro Met Asp Phe Gly Thr Met Lys Asp Lys Ile Val Ala 
            180                 185                 190         


Asn Glu Tyr Lys Ser Val Thr Glu Phe Lys Ala Asp Phe Lys Leu Met 
        195                 200                 205             


Cys Asp Asn Ala Met Thr Tyr Asn Arg Pro Asp Thr Val Tyr Tyr Lys 
    210                 215                 220                 


Leu Ala Lys Lys Ile Leu His Ala Gly Phe Lys Met Met Ser Lys Ala 
225                 230                 235                 240 


Ala Leu Leu Gly Ser Glu Asp Pro Ala Ala Glu Glu Pro Val Pro Glu 
                245                 250                 255     


Val Val Pro Val Gln Val Glu Thr Thr Lys Lys Ser Lys Lys Pro Ser 
            260                 265                 270         


Arg Glu Val Ile Ser Cys Met Phe Glu Pro Glu Gly Asn Ala Cys Ser 
        275                 280                 285             


Leu Thr Asp Ser Thr Ala Glu Glu His Val Leu Ala Leu Val Glu His 
    290                 295                 300                 


Ala Ala Asp Glu Ala Arg Asp Arg Ile Asn Arg Phe Leu Pro Gly Gly 
305                 310                 315                 320 


Lys Met Gly Tyr Leu Lys Lys Leu Gly Asp Gly Ser Leu Leu Tyr Ser 
                325                 330                 335     


Val Val Asn Ala Pro Glu Pro Asp Ala Asp Glu Glu Glu Thr His Pro 
            340                 345                 350         


Val Asp Leu Ser Ser Leu Ser Ser Lys Leu Leu Pro Gly Phe Thr Thr 
        355                 360                 365             


Leu Gly Phe Lys Asp Glu Arg Arg Asn Lys Val Thr Phe Leu Ser Ser 
    370                 375                 380                 


Ala Ser Thr Ala Leu Ser Met Gln Asn Asn Ser Val Phe Gly Asp Leu 
385                 390                 395                 400 


Lys Ser Asp Glu Met Glu Leu Leu Tyr Ser Ala Tyr Gly Asp Glu Thr 
                405                 410                 415     


Gly Val Gln Cys Ala Leu Ser Leu Gln Glu Phe Val Lys Asp Ala Gly 
            420                 425                 430         


Ser Tyr Ser Lys Lys Met Val Asp Asp Leu Leu Asp Gln Ile Thr Gly 
        435                 440                 445             


Gly Asp His Ser Arg Met Ile Phe Gln Leu Lys Gln Arg Arg Ser Ile 
    450                 455                 460                 


Pro Met Arg Pro Ala Asp Glu Met Lys Val Gly Asp Pro Leu Gly Glu 
465                 470                 475                 480 


Ser Gly Gly Pro Val Leu Asp Phe Met Ser Met Lys Gln Tyr Pro Asp 
                485                 490                 495     


Val Ser Leu Asp Val Ser Met Leu Ser Ser Leu Gly Lys Val Lys Lys 
            500                 505                 510         


Glu Leu Asp His Glu Asp Ser His Leu Asn Leu Asp Glu Thr Ala Arg 
        515                 520                 525             


Leu Leu Gln Asp Leu His Glu Ala Gln Ala Glu Arg Gly Gly Ser Arg 
    530                 535                 540                 


Pro Ser Ser Asn Leu Ser Ser Leu Ser Thr Ala Ser Glu Arg Glu His 
545                 550                 555                 560 


Pro Pro Pro Gly Ser Pro Ser Arg Leu Ser Val Gly Glu Gln Pro Asp 
                565                 570                 575     


Val Ala His Asp Pro Tyr Glu Phe Leu Gln Ser Pro Glu Pro Ala Ala 
            580                 585                 590         


Pro Ala Lys Asn 
        595     


<210>  29
<211>  2445
<212>  DNA
<213>  Mus musculus

<400>  29
gcggtggcga aggcgctact tccgactggc gcaggtcgag ctaccggcag ccgcttctca       60

ccggatcccg tgctatctca gccatgggca aaaagcacaa gaagcacaag gcggaatggc      120

gctcgtccta cgaagattat acagacacgc cactggagaa gcctctgaag ctggtgctca      180

aggtgggagg aagtgaagtg acagagctct caggatctgg ccacgactcc agctactacg      240

acgatcgctc agaccacgaa cgggagagac acagagaaaa gaagaaaaag aagaagaaaa      300

agtcagagaa ggagaagcac ctcgatgagg aggagaggag gaagcggaag gaagagaaga      360

aacggaaacg ggagaaggaa cactgcgact cagaggggga ggctgatgct ttcgaccctg      420

gaaagaaggt ggaggtggag ccacccccag accgaccagt gagagcctgc cgaacacagc      480

cagctgagaa cgagagcaca cctatccaga ggcttctgga acacttcctc cgccagctac      540

agagaaaaga tcctcatgga ttttttgctt ttcctgttac ggatgcaatt gctcctgggt      600

attcaatgat aataaaacat cctatggact ttggcacgat gaaagacaag attgtagcta      660

atgaatataa atcagtcaca gaatttaagg cagatttcaa attaatgtgt gataatgcga      720

tgacgtacaa tagaccagac accgtgtact acaaattagc caagaagatc ctgcacgcgg      780

gctttaagat gatgagcaaa gcagctctct tgggcagtga agacccagca gctgaggaac      840

ctgttcccga ggttgtccca gtgcaagtag aaactaccaa gaaatccaaa aagccgagta      900

gagaagttat cagctgcatg tttgagcctg aagggaatgc ctgcagcctg acagacagca      960

cggcagagga gcatgtgcta gccctggtag agcacgcagc tgatgaggct cgggacagga     1020

ttaaccggtt tctcccgggt ggcaagatgg ggtacctgaa gaagcttgga gatggaagtc     1080

tgctctacag cgtggtgaac gcacctgagc ctgatgctga tgaggaggag acacaccctg     1140

tggacctgag ttcactgtct agcaagttgc tcccaggttt tacaacattg ggtttcaaag     1200

atgaaagaag aaataaagtc acattcctct ccagtgccag cactgcactt tcaatgcaga     1260

acaactctgt gtttggggac ctgaagtcag atgagatgga gcttctgtat tccgcctatg     1320

gagatgagac tggtgtgcag tgtgcactga gcctgcagga attcgtgaag gatgctggaa     1380

gctatagcaa gaagatggta gatgacctcc tggaccaaat cacaggtggt gatcactcaa     1440

ggatgatctt ccagctgaag cagaggagga gcatccccat gagacctgca gatgagatga     1500

aggttgggga tccactggga gagagtggtg gccctgttct ggacttcatg tcaatgaaac     1560

agtatcctga tgtctccctg gatgtgtcca tgctcagctc tctcgggaaa gtaaagaagg     1620

agctggacca tgaagatagc cacttgaact tggatgagac agccaggctc ctgcaggact     1680

tacacgaagc acaagcagag cgaggaggct ctcggccatc ctccaacctt agctctctgt     1740

ccactgcctc tgagagggag catcctcctc caggaagtcc ttctcgcctt agtgttgggg     1800

agcagccgga tgtcgcccac gacccttatg aattccttca gtctccagaa cctgcagctc     1860

ctgccaagaa ctaacttgtg gtgttcccag atggtttatt ttatttttct acattttatt     1920

tgatacagtt tttgtcacaa gacagaaact tttgtctcat cctctctggc aagtagcagc     1980

ctgaggaaga tgctggcttg tctgtaccgt cacgtctgca gcagaggccc agtagcaccg     2040

aatggtgtcc aataagctct gagcagtggc aatagaatgt caacggattg caatcagatg     2100

gctcaactct gtgtctcctg agcaccagca gccaagcctg ttcatgatga tgtgcacaca     2160

gtcattctac aggagctttg cacagccttc ctgcagttct caaaggggag cctgcagact     2220

aggccttcag agggttcctt ctgtttccta tttgggcact gagccagagg atggagttgt     2280

ctccctgaca aataatgaac caccccacct tttagaatga agtataaatg aagtcataaa     2340

atgtttcaat gttttgctga gtacctgttt gtatttataa aaaacatgaa cacaggtcct     2400

aataaagaga tgcctaaggc ggtaaaaaaa aaaaaaaaaa aaaaa                     2445


<210>  30
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  /note="Description of Artificial Sequence: Synthetic shRNA"

<400>  30
cagtcactga cagttaataa a                                                 21


<210>  31
<211>  48
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  /note="Description of Artificial Sequence: Synthetic shRNA"

<400>  31
cctaaggtta agtcgccctc gctcgagcga gggcgactta accttagg                    48


<210>  32
<211>  75
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  /note="Description of Artificial Sequence: Synthetic primer"

<400>  32
tgaggatccg cggccgcgcc accatgtacc catacgatgt tccagattac gctatgggca       60

agaagcacaa gaagc                                                        75


<210>  33
<211>  39
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  /note="Description of Artificial Sequence: Synthetic primer"

<400>  33
agagccggcg cggccgctta ggtcttggca gaggccgca                              39


<210>  34
<211>  75
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  /note="Description of Artificial Sequence: Synthetic primer"

<400>  34
tgaggatccg cggccgcgcc accatgtacc catacgatgt tccagattac gctatgggca       60

agaagcacaa gaagc                                                        75


<210>  35
<211>  41
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  /note="Description of Artificial Sequence: Synthetic primer"

<400>  35
agagccggcg cggccgctca acttccacca ggtccacact a                           41


<210>  36
<211>  44
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  /note="Description of Artificial Sequence: Synthetic primer"

<400>  36
tccgtcctcc ccagtttcta cttgtactgg tacaacttca ggga                        44


<210>  37
<211>  31
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  /note="Description of Artificial Sequence: Synthetic primer"

<400>  37
caagtagaaa ctggggagga cggaggctgc t                                      31


<210>  38
<211>  37
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  /note="Description of Artificial Sequence: Synthetic primer"

<400>  38
ggatttcttg gcactctgtg aggtgtctgt tccatct                                37


<210>  39
<211>  35
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  /note="Description of Artificial Sequence: Synthetic primer"

<400>  39
acctcacaga gtgccaagaa atccaaaaag ccgag                                  35


<210>  40
<211>  81
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  /note="Description of Artificial Sequence: Synthetic primer"

<400>  40
tgaggatccg cggccgcgcc accatgtacc catacgatgt tccagattac gctatggatg       60

atgatgatga ctcgtgtctc c                                                 81


<210>  41
<211>  57
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  /note="Description of Artificial Sequence: Synthetic primer"

<400>  41
agagccggcg cggccgctta acactctagg atactattta cagctgcttc taaaatg          57


<210>  42
<211>  95
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  /note="Description of Artificial Sequence: Synthetic primer"

<400>  42
tgaggatccg cggccgcgcc accatgggta agcctatccc taaccctctc ctggtctcga       60

ttctacgatg gatgatgatg atgactcgtg tctcc                                  95


<210>  43
<211>  44
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  /note="Description of Artificial Sequence: Synthetic primer"

<400>  43
gttggcttga acctatactg gcctcagtga gatcaggaag agga                        44


<210>  44
<211>  44
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  /note="Description of Artificial Sequence: Synthetic primer"

<400>  44
tcctcttcct gatctcactg aggccagtat aggttcaagc caac                        44


<210>  45
<211>  43
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  /note="Description of Artificial Sequence: Synthetic primer"

<400>  45
aaaaccctca gggtctacaa gtctcaagtc ttcttcagtg ggc                         43


<210>  46
<211>  43
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  /note="Description of Artificial Sequence: Synthetic primer"

<400>  46
gcccactgaa gaagacttga gacttgtaga ccctgagggt ttt                         43


<210>  47
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  /note="Description of Artificial Sequence: Synthetic siRNA"

<400>  47
ttgctcagat ttcaaagtc                                                    19


<210>  48
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  /note="Description of Artificial Sequence: Synthetic siRNA"

<400>  48
tgagcttgag cccgatgcg                                                    19


<210>  49
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  /note="Description of Artificial Sequence: Synthetic siRNA"

<400>  49
tcactgtcaa gcttctcgg                                                    19


<210>  50
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  /note="Description of Artificial Sequence: Synthetic siRNA"

<400>  50
cgatcattac catctccgc                                                    19


<210>  51
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  /note="Description of Artificial Sequence: Synthetic siRNA"

<400>  51
tactgaatta ttctgcatc                                                    19


<210>  52
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  /note="Description of Artificial Sequence: Synthetic siRNA"

<400>  52
attatcattg aatatccag                                                    19


<210>  53
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  /note="Description of Artificial Sequence: Synthetic siRNA"

<400>  53
taaattccgt aactgactt                                                    19


<210>  54
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  /note="Description of Artificial Sequence: Synthetic siRNA"

<400>  54
tattatcatt gaatatcca                                                    19


<210>  55
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  /note="Description of Artificial Sequence: Synthetic siRNA"

<400>  55
tatcattgaa tatccagga                                                    19
