                        SEQUENCE LISTING

<110>  Casebia Therapeutics Limited Liability Partnership
 
<120>  Compositions and Methods for Delivering Transgenes

<130>  052984-535001WO

<140>  Herewith
<141>  Herewith

<150>  US 62/747,128
<151>  2018-10-17

<160>  111   

<170>  PatentIn version 3.5

<210>  1
<211>  14
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide


<220>
<221>  misc_feature
<223>  linker peptide

<400>  1

Ser Phe Ser Gln Asn Pro Pro Val Leu Lys Arg His Gln Arg 
1               5                   10                  


<210>  2
<211>  25
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<223>  synthetic splice acceptor

<400>  2
ctgacctctt ctcttcctcc cacag                                             25


<210>  3
<211>  32
<212>  DNA
<213>  Homo sapiens


<220>
<221>  misc_feature
<223>  native albumin intron 1/exon 2 splice acceptor, human

<400>  3
ttaacaatcc ttttttttct tcccttgccc ag                                     32


<210>  4
<211>  40
<212>  DNA
<213>  Mus musculus


<220>
<221>  misc_feature
<223>  native albumin intron 1/exon 2 splice acceptor, mouse

<400>  4
ttaaatatgt tgtgtggttt ttctctccct gtttccacag                             40


<210>  5
<211>  49
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<223>  consensus synthetic poly A signal sequence

<400>  5
aataaaagat ctttattttc attagatctg tgtgttggtt ttttgtgtg                   49


<210>  6
<211>  9
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  6

Leu Ala Gly Leu Ile Asp Ala Asp Gly 
1               5                   


<210>  7
<211>  20
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<223>  target site

<400>  7
tgcctttacc ccatcgttac                                                   20


<210>  8
<211>  20
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<223>  target site

<400>  8
tgcctcctcc cgatagttac                                                   20


<210>  9
<211>  20
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<223>  target site

<400>  9
ggacagttcc tgattgttac                                                   20


<210>  10
<211>  20
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<223>  target site

<400>  10
tgccttttcc cgattgttaa                                                   20


<210>  11
<211>  20
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<223>  MALBF3 primer

<400>  11
ttattacggt ctcatagggc                                                   20


<210>  12
<211>  21
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<223>  MALBR5 primer

<400>  12
agtctttctg tcaatgcaca c                                                 21


<210>  13
<211>  100
<212>  RNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<223>  gRNA

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  phosphorothioate linkage

<220>
<221>  modified_base
<222>  (1)..(1)
<223>  um

<220>
<221>  misc_feature
<222>  (2)..(3)
<223>  phosphorothioate linkage

<220>
<221>  modified_base
<222>  (2)..(2)
<223>  gm

<220>
<221>  modified_base
<222>  (3)..(3)
<223>  cm

<220>
<221>  misc_feature
<222>  (3)..(4)
<223>  phosphorothioate linkage

<220>
<221>  modified_base
<222>  (29)..(29)
<223>  gm

<220>
<221>  modified_base
<222>  (30)..(30)
<223>  cm

<220>
<221>  modified_base
<222>  (31)..(31)
<223>  um

<220>
<221>  modified_base
<222>  (32)..(32)
<223>  2'-O-methyladenosine

<220>
<221>  modified_base
<222>  (37)..(37)
<223>  um

<220>
<221>  modified_base
<222>  (38)..(38)
<223>  2'-O-methyladenosine

<220>
<221>  modified_base
<222>  (39)..(39)
<223>  gm

<220>
<221>  modified_base
<222>  (40)..(40)
<223>  cm

<220>
<221>  modified_base
<222>  (68)..(69)
<223>  2'-O-methyladenosine

<220>
<221>  modified_base
<222>  (70)..(70)
<223>  cm

<220>
<221>  modified_base
<222>  (71)..(72)
<223>  um

<220>
<221>  modified_base
<222>  (77)..(78)
<223>  2'-O-methyladenosine

<220>
<221>  modified_base
<222>  (79)..(79)
<223>  gm

<220>
<221>  modified_base
<222>  (80)..(80)
<223>  um

<220>
<221>  modified_base
<222>  (81)..(82)
<223>  gm

<220>
<221>  modified_base
<222>  (83)..(83)
<223>  cm

<220>
<221>  modified_base
<222>  (84)..(84)
<223>  2'-O-methyladenosine

<220>
<221>  modified_base
<222>  (85)..(85)
<223>  cm

<220>
<221>  modified_base
<222>  (86)..(86)
<223>  cm

<220>
<221>  modified_base
<222>  (87)..(87)
<223>  gm

<220>
<221>  modified_base
<222>  (88)..(88)
<223>  2'-O-methyladenosine

<220>
<221>  modified_base
<222>  (89)..(89)
<223>  gm

<220>
<221>  modified_base
<222>  (90)..(90)
<223>  um

<220>
<221>  modified_base
<222>  (91)..(91)
<223>  cm

<220>
<221>  modified_base
<222>  (92)..(93)
<223>  gm

<220>
<221>  modified_base
<222>  (94)..(94)
<223>  um

<220>
<221>  modified_base
<222>  (95)..(95)
<223>  gm

<220>
<221>  modified_base
<222>  (96)..(96)
<223>  cm

<220>
<221>  misc_feature
<222>  (97)..(98)
<223>  phosphorothioate linkage

<220>
<221>  modified_base
<222>  (97)..(99)
<223>  um

<220>
<221>  misc_feature
<222>  (98)..(99)
<223>  phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (99)..(100)
<223>  phosphorothioate linkage

<400>  13
ugccaguucc cgaucguuac guuuuagagc uagaaauagc aaguuaaaau aaggcuaguc       60

cguuaucaac uugaaaaagu ggcaccgagu cggugcuuuu                            100


<210>  14
<211>  20
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<223>  Albumin forward primer

<400>  14
ccctccgttt gtcctagctt                                                   20


<210>  15
<211>  19
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<223>  Albumin reverse primer

<400>  15
tctacgaggc agcactgtt                                                    19


<210>  16
<211>  23
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<223>  AAVS1 forward primer

<400>  16
aactgcttct cctcttggga agt                                               23


<210>  17
<211>  25
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<223>  AAVS1 reverse primer

<400>  17
cctctccatc ctcttgcttt ctttg                                             25


<210>  18
<211>  23
<212>  DNA
<213>  Homo sapiens


<220>
<221>  misc_feature
<223>  Human Albumin Intron-1_T1

<400>  18
taattttctt ttgcgcacta agg                                               23


<210>  19
<211>  23
<212>  DNA
<213>  Homo sapiens


<220>
<221>  misc_feature
<223>  Human Albumin Intron-1_T2

<400>  19
tagtgcaatg gataggtctt tgg                                               23


<210>  20
<211>  23
<212>  DNA
<213>  Homo sapiens


<220>
<221>  misc_feature
<223>  Human Albumin Intron-1_T3

<400>  20
agtgcaatgg ataggtcttt ggg                                               23


<210>  21
<211>  23
<212>  DNA
<213>  Homo sapiens


<220>
<221>  misc_feature
<223>  Human Albumin Intron-1_T4

<400>  21
taaagcatag tgcaatggat agg                                               23


<210>  22
<211>  23
<212>  DNA
<213>  Homo sapiens


<220>
<221>  misc_feature
<223>  Human Albumin Intron-1_T5

<400>  22
atttatgaga tcaacagcac agg                                               23


<210>  23
<211>  23
<212>  DNA
<213>  Homo sapiens


<220>
<221>  misc_feature
<223>  Human Albumin Intron-1_T6

<400>  23
tgattcctac agaaaaactc agg                                               23


<210>  24
<211>  23
<212>  DNA
<213>  Homo sapiens


<220>
<221>  misc_feature
<223>  Human Albumin Intron-1_T7

<400>  24
tgtatttgtg aagtcttaca agg                                               23


<210>  25
<211>  23
<212>  DNA
<213>  Homo sapiens


<220>
<221>  misc_feature
<223>  Human Albumin Intron-1_T8

<400>  25
gactgaaact tcacagaata ggg                                               23


<210>  26
<211>  23
<212>  DNA
<213>  Homo sapiens


<220>
<221>  misc_feature
<223>  Human Albumin Intron-1_T9

<400>  26
aatgcataat ctaagtcaaa tgg                                               23


<210>  27
<211>  23
<212>  DNA
<213>  Homo sapiens


<220>
<221>  misc_feature
<223>  Human Albumin Intron-1_T10

<400>  27
tgactgaaac ttcacagaat agg                                               23


<210>  28
<211>  23
<212>  DNA
<213>  Homo sapiens


<220>
<221>  misc_feature
<223>  Human Albumin Intron-1_T11

<400>  28
ttaaataaag catagtgcaa tgg                                               23


<210>  29
<211>  23
<212>  DNA
<213>  Homo sapiens


<220>
<221>  misc_feature
<223>  Human Albumin Intron-1_T12

<400>  29
gatcaacagc acaggttttg tgg                                               23


<210>  30
<211>  23
<212>  DNA
<213>  Homo sapiens


<220>
<221>  misc_feature
<223>  Human Albumin Intron-1_T13

<400>  30
taataaaatt caaacatcct agg                                               23


<210>  31
<211>  23
<212>  DNA
<213>  Homo sapiens


<220>
<221>  misc_feature
<223>  Human Albumin Intron-1_T14

<400>  31
ttcattttag tctgtcttct tgg                                               23


<210>  32
<211>  23
<212>  DNA
<213>  Homo sapiens


<220>
<221>  misc_feature
<223>  Human Albumin Intron-1_T15

<400>  32
attatctaag tttgaatata agg                                               23


<210>  33
<211>  23
<212>  DNA
<213>  Homo sapiens


<220>
<221>  misc_feature
<223>  Human Albumin Intron-1_T16

<400>  33
atcatcctga gtttttctgt agg                                               23


<210>  34
<211>  23
<212>  DNA
<213>  Homo sapiens


<220>
<221>  misc_feature
<223>  Human Albumin Intron-1_T17

<400>  34
gcatctttaa agaattattt tgg                                               23


<210>  35
<211>  23
<212>  DNA
<213>  Homo sapiens


<220>
<221>  misc_feature
<223>  Human Albumin Intron-1_T18

<400>  35
tactaaaact ttattttact ggg                                               23


<210>  36
<211>  23
<212>  DNA
<213>  Homo sapiens


<220>
<221>  misc_feature
<223>  Human Albumin Intron-1_T19

<400>  36
tgaattattc ttctgtttaa agg                                               23


<210>  37
<211>  23
<212>  DNA
<213>  Homo sapiens


<220>
<221>  misc_feature
<223>  Human Albumin Intron-1_T20

<400>  37
aatttttaaa atagtattct tgg                                               23


<210>  38
<211>  23
<212>  DNA
<213>  Homo sapiens


<220>
<221>  misc_feature
<223>  Human Albumin Intron-1_T21

<400>  38
atgcatttgt ttcaaaatat tgg                                               23


<210>  39
<211>  23
<212>  DNA
<213>  Homo sapiens


<220>
<221>  misc_feature
<223>  Human Albumin Intron-1_T22

<400>  39
tttggcattt atttctaaaa tgg                                               23


<210>  40
<211>  23
<212>  DNA
<213>  Homo sapiens


<220>
<221>  misc_feature
<223>  Human Albumin Intron-1_T23

<400>  40
aaagttgaac aatagaaaaa tgg                                               23


<210>  41
<211>  23
<212>  DNA
<213>  Homo sapiens


<220>
<221>  misc_feature
<223>  Human Albumin Intron-1_T24

<400>  41
ttactaaaac tttattttac tgg                                               23


<210>  42
<211>  23
<212>  DNA
<213>  Homo sapiens


<220>
<221>  misc_feature
<223>  Human Albumin Intron-1_T26

<400>  42
tgcatttgtt tcaaaatatt ggg                                               23


<210>  43
<211>  23
<212>  DNA
<213>  Homo sapiens


<220>
<221>  misc_feature
<223>  Human Albumin Intron-1_T27

<400>  43
tgggcaaggg aagaaaaaaa agg                                               23


<210>  44
<211>  23
<212>  DNA
<213>  Homo sapiens


<220>
<221>  misc_feature
<223>  Human Albumin Intron-1_T28

<400>  44
tcctaggtaa aaaaaaaaaa agg                                               23


<210>  45
<211>  23
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide

<400>  45
taattttctt ttgcccacta agg                                               23


<210>  46
<211>  23
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide

<400>  46
tagtgcaatg gataggtctt agg                                               23


<210>  47
<211>  23
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide

<400>  47
agtgcaatgg ataggtctta ggg                                               23


<210>  48
<211>  23
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide

<400>  48
taaagcatag tgcaatggat agg                                               23


<210>  49
<211>  23
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide

<400>  49
atttatgaga tcaacagcac agg                                               23


<210>  50
<211>  23
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide

<400>  50
tgattcctac agaaaaagtc agg                                               23


<210>  51
<211>  23
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide

<400>  51
aatgcataat ctaagtcaaa tgg                                               23


<210>  52
<211>  23
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide

<400>  52
ttaaataaag catagtgcaa tgg                                               23


<210>  53
<211>  23
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide

<400>  53
atttatgaga tcaacagcac agg                                               23


<210>  54
<211>  23
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide

<400>  54
taataaaatt caaacatcct agg                                               23


<210>  55
<211>  23
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide

<400>  55
attatcctga ctttttctgt agg                                               23


<210>  56
<211>  23
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide

<400>  56
tactaaaact ttattttact tgg                                               23


<210>  57
<211>  23
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide

<400>  57
tgaattattc ctctgtttaa agg                                               23


<210>  58
<211>  23
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide

<400>  58
atgcatttgt ttcaaaatat tgg                                               23


<210>  59
<211>  23
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide

<400>  59
tttggcattt atttctaaaa tgg                                               23


<210>  60
<211>  23
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide

<400>  60
aaagttgaac aatagaaaaa tgg                                               23


<210>  61
<211>  23
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide

<400>  61
tgcatttgtt tcaaaatatt ggg                                               23


<210>  62
<211>  23
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide

<400>  62
taattttctt ttgcccacta agg                                               23


<210>  63
<211>  23
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide

<400>  63
tagtgcaatg gataggtctt agg                                               23


<210>  64
<211>  23
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide

<400>  64
agtgcaatgg ataggtctta ggg                                               23


<210>  65
<211>  23
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide

<400>  65
taaagcatag tgcaatggat agg                                               23


<210>  66
<211>  23
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide

<400>  66
atttatgaga tcaacagcac agg                                               23


<210>  67
<211>  23
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide

<400>  67
tgattcctac agaaaaagtc agg                                               23


<210>  68
<211>  23
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide

<400>  68
aatgcataat ctaagtcaaa tgg                                               23


<210>  69
<211>  23
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide

<400>  69
ttaaataaag catagtgcaa tgg                                               23


<210>  70
<211>  23
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide

<400>  70
atttatgaga tcaacagcac agg                                               23


<210>  71
<211>  23
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide

<400>  71
taataaaatt caaacatcct agg                                               23


<210>  72
<211>  23
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide

<400>  72
attatcctga ctttttctgt agg                                               23


<210>  73
<211>  23
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide

<400>  73
tactaaaact ttattttact tgg                                               23


<210>  74
<211>  23
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide

<400>  74
tgaattattc ctctgtttaa agg                                               23


<210>  75
<211>  23
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide

<400>  75
atgcatttgt ttcaaaatat tgg                                               23


<210>  76
<211>  23
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide

<400>  76
tttggcattt atttctaaaa tgg                                               23


<210>  77
<211>  23
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide

<400>  77
aaagttgaac aatagaaaaa tgg                                               23


<210>  78
<211>  23
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide

<400>  78
tgcatttgtt tcaaaatatt ggg                                               23


<210>  79
<211>  23
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide

<400>  79
tggggaaggg gagaaaaaaa agg                                               23


<210>  80
<211>  23
<212>  DNA
<213>  Mus musculus


<220>
<221>  misc_feature
<223>  Mouse albumin intron 1 gRNA sequence, mALbgRNA_T1

<220>
<221>  misc_feature
<222>  (21)..(23)
<223>  PAM sequence

<400>  80
tgccagttcc cgatcgttac agg                                               23


<210>  81
<211>  4438
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<223>  spCas9 mRNA

<400>  81
ggaaataaga gagaaaagaa gagtaagaag aaatataaga gccaccatgg ccccaaagaa       60

gaagcggaag gtcggtatcc acggagtccc agcagccgac aagaagtaca gcatcggcct      120

ggacatcggc accaactctg tgggctgggc cgtgatcacc gacgagtaca aggtgcccag      180

caagaaattc aaggtgctgg gcaacaccga ccggcacagc atcaagaaga acctgatcgg      240

agccctgctg ttcgacagcg gcgaaacagc cgaggccacc cggctgaaga gaaccgccag      300

aagaagatac accagacgga agaaccggat ctgctatctg caagagatct tcagcaacga      360

gatggccaag gtggacgaca gcttcttcca cagactggaa gagtccttcc tggtggaaga      420

ggacaagaag cacgagagac accccatctt cggcaacatc gtggacgagg tggcctacca      480

cgagaagtac cccaccatct accacctgag aaagaaactg gtggacagca ccgacaaggc      540

cgacctgaga ctgatctacc tggccctggc ccacatgatc aagttcagag gccacttcct      600

gatcgagggc gacctgaacc ccgacaacag cgacgtggac aagctgttca tccagctggt      660

gcagacctac aaccagctgt tcgaggaaaa ccccatcaac gccagcggcg tggacgccaa      720

ggctatcctg tctgccagac tgagcaagag cagaaggctg gaaaatctga tcgcccagct      780

gcccggcgag aagaagaacg gcctgttcgg caacctgatt gccctgagcc tgggcctgac      840

ccccaacttc aagagcaact tcgacctggc cgaggatgcc aaactgcagc tgagcaagga      900

cacctacgac gacgacctgg acaacctgct ggcccagatc ggcgaccagt acgccgacct      960

gttcctggcc gccaagaacc tgtctgacgc catcctgctg agcgacatcc tgagagtgaa     1020

caccgagatc accaaggccc ccctgagcgc ctctatgatc aagagatacg acgagcacca     1080

ccaggacctg accctgctga aagctctcgt gcggcagcag ctgcctgaga agtacaaaga     1140

aatcttcttc gaccagagca agaacggcta cgccggctac atcgatggcg gcgctagcca     1200

ggaagagttc tacaagttca tcaagcccat cctggaaaag atggacggca ccgaggaact     1260

gctcgtgaag ctgaacagag aggacctgct gagaaagcag agaaccttcg acaacggcag     1320

catcccccac cagatccacc tgggagagct gcacgctatc ctgagaaggc aggaagattt     1380

ttacccattc ctgaaggaca accgggaaaa gatcgagaag atcctgacct tcaggatccc     1440

ctactacgtg ggccccctgg ccagaggcaa cagcagattc gcctggatga ccagaaagag     1500

cgaggaaacc atcaccccct ggaacttcga ggaagtggtg gacaagggcg ccagcgccca     1560

gagcttcatc gagagaatga caaacttcga taagaacctg cccaacgaga aggtgctgcc     1620

caagcacagc ctgctgtacg agtacttcac cgtgtacaac gagctgacca aagtgaaata     1680

cgtgaccgag ggaatgagaa agcccgcctt cctgagcggc gagcagaaaa aggccatcgt     1740

ggacctgctg ttcaagacca acagaaaagt gaccgtgaag cagctgaaag aggactactt     1800

caagaaaatc gagtgcttcg actccgtgga aatctccggc gtggaagata gattcaacgc     1860

ctccctgggc acataccacg atctgctgaa aattatcaag gacaaggact tcctggataa     1920

cgaagagaac gaggacattc tggaagatat cgtgctgacc ctgacactgt ttgaggaccg     1980

cgagatgatc gaggaaaggc tgaaaaccta cgctcacctg ttcgacgaca aagtgatgaa     2040

gcagctgaag agaaggcggt acaccggctg gggcaggctg agcagaaagc tgatcaacgg     2100

catcagagac aagcagagcg gcaagacaat cctggatttc ctgaagtccg acggcttcgc     2160

caaccggaac ttcatgcagc tgatccacga cgacagcctg acattcaaag aggacatcca     2220

gaaagcccag gtgtccggcc agggcgactc tctgcacgag catatcgcta acctggccgg     2280

cagccccgct atcaagaagg gcatcctgca gacagtgaag gtggtggacg agctcgtgaa     2340

agtgatgggc agacacaagc ccgagaacat cgtgatcgag atggctagag agaaccagac     2400

cacccagaag ggacagaaga actcccgcga gaggatgaag agaatcgaag agggcatcaa     2460

agagctgggc agccagatcc tgaaagaaca ccccgtggaa aacacccagc tgcagaacga     2520

gaagctgtac ctgtactacc tgcagaatgg ccgggatatg tacgtggacc aggaactgga     2580

catcaacaga ctgtccgact acgatgtgga ccatatcgtg cctcagagct ttctgaagga     2640

cgactccatc gataacaaag tgctgactcg gagcgacaag aacagaggca agagcgacaa     2700

cgtgccctcc gaagaggtcg tgaagaagat gaagaactac tggcgacagc tgctgaacgc     2760

caagctgatt acccagagga agttcgataa cctgaccaag gccgagagag gcggcctgag     2820

cgagctggat aaggccggct tcatcaagag gcagctggtg gaaaccagac agatcacaaa     2880

gcacgtggca cagatcctgg actcccggat gaacactaag tacgacgaaa acgataagct     2940

gatccgggaa gtgaaagtga tcaccctgaa gtccaagctg gtgtccgatt tccggaagga     3000

tttccagttt tacaaagtgc gcgagatcaa caactaccac cacgcccacg acgcctacct     3060

gaacgccgtc gtgggaaccg ccctgatcaa aaagtaccct aagctggaaa gcgagttcgt     3120

gtacggcgac tacaaggtgt acgacgtgcg gaagatgatc gccaagagcg agcaggaaat     3180

cggcaaggct accgccaagt acttcttcta cagcaacatc atgaactttt tcaagaccga     3240

aatcaccctg gccaacggcg agatcagaaa gcgccctctg atcgagacaa acggcgaaac     3300

cggggagatc gtgtgggata agggcagaga cttcgccaca gtgcgaaagg tgctgagcat     3360

gccccaagtg aatatcgtga aaaagaccga ggtgcagaca ggcggcttca gcaaagagtc     3420

tatcctgccc aagaggaaca gcgacaagct gatcgccaga aagaaggact gggaccccaa     3480

gaagtacggc ggcttcgaca gccctaccgt ggcctactct gtgctggtgg tggctaaggt     3540

ggaaaagggc aagtccaaga aactgaagag tgtgaaagag ctgctgggga tcaccatcat     3600

ggaaagaagc agctttgaga agaaccctat cgactttctg gaagccaagg gctacaaaga     3660

agtgaaaaag gacctgatca tcaagctgcc taagtactcc ctgttcgagc tggaaaacgg     3720

cagaaagaga atgctggcct ctgccggcga actgcagaag ggaaacgagc tggccctgcc     3780

tagcaaatat gtgaacttcc tgtacctggc ctcccactat gagaagctga agggcagccc     3840

tgaggacaac gaacagaaac agctgtttgt ggaacagcat aagcactacc tggacgagat     3900

catcgagcag atcagcgagt tctccaagag agtgatcctg gccgacgcca atctggacaa     3960

ggtgctgtct gcctacaaca agcacaggga caagcctatc agagagcagg ccgagaatat     4020

catccacctg ttcaccctga caaacctggg cgctcctgcc gccttcaagt actttgacac     4080

caccatcgac cggaagaggt acaccagcac caaagaggtg ctggacgcca ccctgatcca     4140

ccagagcatc accggcctgt acgagacaag aatcgacctg tctcagctgg gaggcgacaa     4200

gagacctgcc gccactaaga aggccggaca ggccaaaaag aagaagtgag cggccgctta     4260

attaagctgc cttctgcggg gcttgccttc tggccatgcc cttcttctct cccttgcacc     4320

tgtacctctt ggtctttgaa taaagcctga gtaggaagaa aaaaaaaaaa aaaaaaaaaa     4380

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaa       4438


<210>  82
<211>  25
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<223>  Synthetic splice acceptor

<400>  82
ctgacctctt ctcttcctcc cacag                                             25


<210>  83
<211>  42
<212>  DNA
<213>  Mus musculus


<220>
<221>  misc_feature
<223>  Mouse albumin Intron 1 splice acceptor

<400>  83
ctttaaatat gttgtgtggt ttttctctcc ctgtttccac ag                          42


<210>  84
<211>  33
<212>  DNA
<213>  Mus musculus


<220>
<221>  misc_feature
<223>  Mouse albumin Intron 2 splice acceptor

<400>  84
cctcatactg aggtttttgt gtctgctttt cag                                    33


<210>  85
<211>  32
<212>  DNA
<213>  Homo sapiens


<220>
<221>  misc_feature
<223>  Human albumin Intron 1 splice acceptor

<400>  85
ttaacaatcc ttttttttct tcccttgccc ag                                     32


<210>  86
<211>  34
<212>  DNA
<213>  Homo sapiens


<220>
<221>  misc_feature
<223>  Human albumin Intron 2 splice acceptor

<400>  86
attatactac atttttctac atcctttgtt tcag                                   34


<210>  87
<211>  4402
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<223>  MAB8A

<400>  87
aattgctgac ctcttctctt cctcccacag tggccaccag aagatactac ctcggagccg       60

tcgaattgag ctgggattac atgcaatccg acctgggaga actgcccgtg gatgccaggt      120

ttcctcctcg ggtccccaag tccttcccgt tcaacacctc agtcgtctac aagaaaaccc      180

tcttcgtgga gttcaccgac catctgttca acatcgccaa gccaagaccc ccgtggatgg      240

gactcctcgg tccgaccatc caagccgaag tgtacgacac tgtggtcatt accctgaaga      300

acatggcctc ccatcctgtg tccctgcatg cagtgggcgt gtcctactgg aaggcttccg      360

aaggggccga gtacgacgat caaaccagcc agcgggaaaa ggaggatgac aaagtgttcc      420

cgggtggttc gcacacctac gtgtggcaag tgctcaagga gaacggtcct atggcctctg      480

atcccctgtg tctgacctac tcctacctgt cccatgtcga cctcgtgaag gatctgaaca      540

gcgggctgat tggcgccctg ctcgtgtgcc gggaaggctc cctggccaag gaaaagaccc      600

agacactgca caagttcatc ttgctgttcg ccgtgtttga tgagggaaag tcctggcata      660

gcgagactaa gaactccctt atgcaagacc gggatgctgc ctccgctagg gcttggccta      720

agatgcatac tgtgaacgga tacgtgaaca gatccctgcc tggccttatc ggttgccacc      780

ggaagtccgt gtattggcat gtgatcggca tgggaaccac tccagaggtg cactccattt      840

tcttggaggg gcataccttc ttggtgcgca accacagaca ggcctccctg gaaatttctc      900

cgatcacttt cctgactgcc cagaccctcc ttatggacct gggtcagttc ctgctgttct      960

gccacatttc gtcccaccaa cacgatggca tggaagccta cgtgaaagtg gactcgtgcc     1020

cggaagaacc acagctgcgg atgaagaaca acgaagaggc agaggactac gatgatgatc     1080

ttaccgattc ggaaatggat gtggtccgat tcgacgacga taatagccca tccttcatcc     1140

aaattaggag cgtggccaag aagcacccca aaacttgggt gcattacatt gcggccgagg     1200

aagaggattg ggactacgca cccctcgtgc ttgcacccga tgatcggtcc tacaagtccc     1260

aatacctgaa caacggcccg cagaggatcg gtcggaagta taagaaagtg cgcttcatgg     1320

cctacaccga cgagactttc aagaccagag aggccattca gcacgaaagc ggcattctgg     1380

ggccgctgtt gtacggggag gtcggagata cactgctcat cattttcaag aaccaggcgt     1440

ccagacccta caacatctac ccgcacggaa tcactgacgt ccgccccctg tactcccgga     1500

gactcccgaa gggagtcaag cacttgaaag acttccccat cctgcctggg gaaatcttca     1560

agtacaagtg gaccgtgacc gtcgaggatg ggccgaccaa gtccgatcca agatgcctca     1620

ctagatacta ctcatccttc gtcaacatgg aacgggacct ggcctcagga ctgattggcc     1680

ccctgctcat ctgctacaag gagtccgtgg atcagcgcgg aaaccagatc atgtcggaca     1740

aacgcaacgt catcctcttc tccgtctttg acgagaaccg ctcatggtac cttacggaga     1800

acatccagcg gttcctcccc aaccctgccg gagtgcagct cgaggacccg gaattccagg     1860

catcaaacat tatgcactcc atcaacggtt acgtgttcga cagcctccag cttagcgtgt     1920

gcctccatga agtcgcatat tggtacatcc tgtccattgg agcacaaacc gactttctct     1980

ccgtgttctt ctccggatat accttcaagc acaagatggt gtacgaggat accctgaccc     2040

tcttcccctt ctccggagag actgtgttta tgtcgatgga aaacccaggc ctgtggattt     2100

tggggtgcca caactcggat ttccgaaacc ggggcatgac tgccttgctc aaggtgtcct     2160

cctgtgacaa gaacacggga gactactacg aggactccta cgaggatatt tccgcctacc     2220

tcctgtccaa gaacaacgcc atcgaaccca ggtccttcag ccagaaccct cctgtcctca     2280

agcgccatca gagagaaatc acccgcacga ccctgcagtc cgaccaggaa gagatcgatt     2340

acgacgacac tatctccgtc gaaatgaaga aggaggactt tgacatctac gacgaagatg     2400

aaaatcagtc ccctcgctcg ttccaaaaga aaacgagaca ctacttcatc gctgctgtgg     2460

agcggctctg ggactacggc atgtcctcat cgccccacgt gcttaggaac cgggctcaat     2520

ccgggagcgt ccctcagttc aagaaagtgg tgtttcaaga attcaccgat ggaagcttca     2580

cgcagccgtt gtacaggggc gaactgaacg agcaccttgg cctgctggga ccttacatca     2640

gagcagaggt cgaggacaac atcatggtga ccttccggaa ccaagcctcc cggccatatt     2700

cattctactc gagccttatc tcatacgagg aggatcagag acagggggct gaacctcgga     2760

agaacttcgt caagccgaac gagacaaaga cctacttttg gaaggtgcag caccacatgg     2820

ccccgaccaa ggatgagttc gactgcaagg cctgggcgta cttctccgac gtggatctcg     2880

aaaaggacgt gcattccggg ctgatcggac cgctgctcgt ctgccacact aacaccctca     2940

atcctgctca cggcagacaa gtgaccgtgc aggagttcgc cctgttcttc accatcttcg     3000

acgaaactaa gtcatggtac tttaccgaga acatggagcg gaattgtcgg gccccatgta     3060

acatccagat ggaggacccg acattcaagg agaactaccg gttccacgcc attaacggat     3120

acattatgga cactcttccg ggactcgtga tggcacagga ccaacgcatc agatggtatc     3180

ttctgtcgat ggggagcaac gaaaacatcc attcgatcca ctttagcggt cacgtgttca     3240

cagtgcgcaa gaaggaagag tacaagatgg cgctgtacaa cctgtaccct ggggtgttcg     3300

agactgtgga aatgctgccg tccaaggccg gaatttggcg cgtggaatgt ctgatcggtg     3360

aacatctgca tgccggaatg tccaccctgt tcctggtgta ctccaacaag tgccaaaccc     3420

cactgggaat ggcatcagga cacattagag acttccagat taccgcgagc ggacagtacg     3480

gacaatgggc ccccaagttg gccaggctgc actactctgg aagcattaac gcctggagca     3540

ccaaggagcc gttcagctgg atcaaggtgg accttctggc gccaatgatc atccacggaa     3600

ttaagactca gggagcccgc cagaagttct catcgctcta catctcccag tttatcatca     3660

tgtactcact ggatgggaag aagtggcaga cttaccgggg aaattccacc ggtactctga     3720

tggtgttctt cggaaacgtg gacagctccg gcatcaagca caatatcttt aacccgccta     3780

tcatcgcccg atacatccgg ctccacccga ctcactactc catccggtcg actctgcgga     3840

tggaactcat gggttgcgac ctcaactcct gctcaatgcc actgggcatg gagtccaagg     3900

ctatctcgga cgctcagatt actgcatcgt cgtactttac caacatgttc gctacctggt     3960

ccccgtccaa agcccggctg catctccaag gcagatcaaa cgcgtggagg cctcaggtca     4020

acaacccgaa ggaatggctt caggtcgact tccaaaagac catgaaagtc accggagtga     4080

ccacccaggg cgtgaaatcg ctgctgacct ctatgtacgt gaaggaattc ctgatctcat     4140

caagccagga cggccaccag tggacactgt tcttccaaaa tggaaaggtc aaggtctttc     4200

agggaaatca agactccttc acccccgtgg tgaactccct ggacccccct ctgcttaccc     4260

gctacttgcg cattcatccg caatcctggg tgcaccagat cgccctgcga atggaagtgc     4320

tgggctgtga agcgcaggac ctgtactaaa ataaaagatc tttattttca ttagatctgt     4380

gtgttggttt tttgtgtgcc gc                                              4402


<210>  88
<211>  4502
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<223>  MAB8B

<400>  88
aattgaactt tgagtgtagc agagaggaac cattgccacc ttcagatttt aatgtctgac       60

ctcttctctt cctcccacag tggccaccag aagatactac ctcggagccg tcgaattgag      120

ctgggattac atgcaatccg acctgggaga actgcccgtg gatgccaggt ttcctcctcg      180

ggtccccaag tccttcccgt tcaacacctc agtcgtctac aagaaaaccc tcttcgtgga      240

gttcaccgac catctgttca acatcgccaa gccaagaccc ccgtggatgg gactcctcgg      300

tccgaccatc caagccgaag tgtacgacac tgtggtcatt accctgaaga acatggcctc      360

ccatcctgtg tccctgcatg cagtgggcgt gtcctactgg aaggcttccg aaggggccga      420

gtacgacgat caaaccagcc agcgggaaaa ggaggatgac aaagtgttcc cgggtggttc      480

gcacacctac gtgtggcaag tgctcaagga gaacggtcct atggcctctg atcccctgtg      540

tctgacctac tcctacctgt cccatgtcga cctcgtgaag gatctgaaca gcgggctgat      600

tggcgccctg ctcgtgtgcc gggaaggctc cctggccaag gaaaagaccc agacactgca      660

caagttcatc ttgctgttcg ccgtgtttga tgagggaaag tcctggcata gcgagactaa      720

gaactccctt atgcaagacc gggatgctgc ctccgctagg gcttggccta agatgcatac      780

tgtgaacgga tacgtgaaca gatccctgcc tggccttatc ggttgccacc ggaagtccgt      840

gtattggcat gtgatcggca tgggaaccac tccagaggtg cactccattt tcttggaggg      900

gcataccttc ttggtgcgca accacagaca ggcctccctg gaaatttctc cgatcacttt      960

cctgactgcc cagaccctcc ttatggacct gggtcagttc ctgctgttct gccacatttc     1020

gtcccaccaa cacgatggca tggaagccta cgtgaaagtg gactcgtgcc cggaagaacc     1080

acagctgcgg atgaagaaca acgaagaggc agaggactac gatgatgatc ttaccgattc     1140

ggaaatggat gtggtccgat tcgacgacga taatagccca tccttcatcc aaattaggag     1200

cgtggccaag aagcacccca aaacttgggt gcattacatt gcggccgagg aagaggattg     1260

ggactacgca cccctcgtgc ttgcacccga tgatcggtcc tacaagtccc aatacctgaa     1320

caacggcccg cagaggatcg gtcggaagta taagaaagtg cgcttcatgg cctacaccga     1380

cgagactttc aagaccagag aggccattca gcacgaaagc ggcattctgg ggccgctgtt     1440

gtacggggag gtcggagata cactgctcat cattttcaag aaccaggcgt ccagacccta     1500

caacatctac ccgcacggaa tcactgacgt ccgccccctg tactcccgga gactcccgaa     1560

gggagtcaag cacttgaaag acttccccat cctgcctggg gaaatcttca agtacaagtg     1620

gaccgtgacc gtcgaggatg ggccgaccaa gtccgatcca agatgcctca ctagatacta     1680

ctcatccttc gtcaacatgg aacgggacct ggcctcagga ctgattggcc ccctgctcat     1740

ctgctacaag gagtccgtgg atcagcgcgg aaaccagatc atgtcggaca aacgcaacgt     1800

catcctcttc tccgtctttg acgagaaccg ctcatggtac cttacggaga acatccagcg     1860

gttcctcccc aaccctgccg gagtgcagct cgaggacccg gaattccagg catcaaacat     1920

tatgcactcc atcaacggtt acgtgttcga cagcctccag cttagcgtgt gcctccatga     1980

agtcgcatat tggtacatcc tgtccattgg agcacaaacc gactttctct ccgtgttctt     2040

ctccggatat accttcaagc acaagatggt gtacgaggat accctgaccc tcttcccctt     2100

ctccggagag actgtgttta tgtcgatgga aaacccaggc ctgtggattt tggggtgcca     2160

caactcggat ttccgaaacc ggggcatgac tgccttgctc aaggtgtcct cctgtgacaa     2220

gaacacggga gactactacg aggactccta cgaggatatt tccgcctacc tcctgtccaa     2280

gaacaacgcc atcgaaccca ggtccttcag ccagaaccct cctgtcctca agcgccatca     2340

gagagaaatc acccgcacga ccctgcagtc cgaccaggaa gagatcgatt acgacgacac     2400

tatctccgtc gaaatgaaga aggaggactt tgacatctac gacgaagatg aaaatcagtc     2460

ccctcgctcg ttccaaaaga aaacgagaca ctacttcatc gctgctgtgg agcggctctg     2520

ggactacggc atgtcctcat cgccccacgt gcttaggaac cgggctcaat ccgggagcgt     2580

ccctcagttc aagaaagtgg tgtttcaaga attcaccgat ggaagcttca cgcagccgtt     2640

gtacaggggc gaactgaacg agcaccttgg cctgctggga ccttacatca gagcagaggt     2700

cgaggacaac atcatggtga ccttccggaa ccaagcctcc cggccatatt cattctactc     2760

gagccttatc tcatacgagg aggatcagag acagggggct gaacctcgga agaacttcgt     2820

caagccgaac gagacaaaga cctacttttg gaaggtgcag caccacatgg ccccgaccaa     2880

ggatgagttc gactgcaagg cctgggcgta cttctccgac gtggatctcg aaaaggacgt     2940

gcattccggg ctgatcggac cgctgctcgt ctgccacact aacaccctca atcctgctca     3000

cggcagacaa gtgaccgtgc aggagttcgc cctgttcttc accatcttcg acgaaactaa     3060

gtcatggtac tttaccgaga acatggagcg gaattgtcgg gccccatgta acatccagat     3120

ggaggacccg acattcaagg agaactaccg gttccacgcc attaacggat acattatgga     3180

cactcttccg ggactcgtga tggcacagga ccaacgcatc agatggtatc ttctgtcgat     3240

ggggagcaac gaaaacatcc attcgatcca ctttagcggt cacgtgttca cagtgcgcaa     3300

gaaggaagag tacaagatgg cgctgtacaa cctgtaccct ggggtgttcg agactgtgga     3360

aatgctgccg tccaaggccg gaatttggcg cgtggaatgt ctgatcggtg aacatctgca     3420

tgccggaatg tccaccctgt tcctggtgta ctccaacaag tgccaaaccc cactgggaat     3480

ggcatcagga cacattagag acttccagat taccgcgagc ggacagtacg gacaatgggc     3540

ccccaagttg gccaggctgc actactctgg aagcattaac gcctggagca ccaaggagcc     3600

gttcagctgg atcaaggtgg accttctggc gccaatgatc atccacggaa ttaagactca     3660

gggagcccgc cagaagttct catcgctcta catctcccag tttatcatca tgtactcact     3720

ggatgggaag aagtggcaga cttaccgggg aaattccacc ggtactctga tggtgttctt     3780

cggaaacgtg gacagctccg gcatcaagca caatatcttt aacccgccta tcatcgcccg     3840

atacatccgg ctccacccga ctcactactc catccggtcg actctgcgga tggaactcat     3900

gggttgcgac ctcaactcct gctcaatgcc actgggcatg gagtccaagg ctatctcgga     3960

cgctcagatt actgcatcgt cgtactttac caacatgttc gctacctggt ccccgtccaa     4020

agcccggctg catctccaag gcagatcaaa cgcgtggagg cctcaggtca acaacccgaa     4080

ggaatggctt caggtcgact tccaaaagac catgaaagtc accggagtga ccacccaggg     4140

cgtgaaatcg ctgctgacct ctatgtacgt gaaggaattc ctgatctcat caagccagga     4200

cggccaccag tggacactgt tcttccaaaa tggaaaggtc aaggtctttc agggaaatca     4260

agactccttc acccccgtgg tgaactccct ggacccccct ctgcttaccc gctacttgcg     4320

cattcatccg caatcctggg tgcaccagat cgccctgcga atggaagtgc tgggctgtga     4380

agcgcaggac ctgtactaaa ataaaagatc tttattttca ttagatctgt gtgttggttt     4440

tttgtgtgcg atcgggaact ggcatcttca gggagtagct taggtcagtg aagagaagcc     4500

gc                                                                    4502


<210>  89
<211>  4567
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<223>  MAB8C

<400>  89
gcggcctaag gcaattgtgc cagttcccga tcgttacagg aactttgagt gtagcagaga       60

ggaaccattg ccaccttcag attttaatgt ctgacctctt ctcttcctcc cacagtggcc      120

accagaagat actacctcgg agccgtcgaa ttgagctggg attacatgca atccgacctg      180

ggagaactgc ccgtggatgc caggtttcct cctcgggtcc ccaagtcctt cccgttcaac      240

acctcagtcg tctacaagaa aaccctcttc gtggagttca ccgaccatct gttcaacatc      300

gccaagccaa gacccccgtg gatgggactc ctcggtccga ccatccaagc cgaagtgtac      360

gacactgtgg tcattaccct gaagaacatg gcctcccatc ctgtgtccct gcatgcagtg      420

ggcgtgtcct actggaaggc ttccgaaggg gccgagtacg acgatcaaac cagccagcgg      480

gaaaaggagg atgacaaagt gttcccgggt ggttcgcaca cctacgtgtg gcaagtgctc      540

aaggagaacg gtcctatggc ctctgatccc ctgtgtctga cctactccta cctgtcccat      600

gtcgacctcg tgaaggatct gaacagcggg ctgattggcg ccctgctcgt gtgccgggaa      660

ggctccctgg ccaaggaaaa gacccagaca ctgcacaagt tcatcttgct gttcgccgtg      720

tttgatgagg gaaagtcctg gcatagcgag actaagaact cccttatgca agaccgggat      780

gctgcctccg ctagggcttg gcctaagatg catactgtga acggatacgt gaacagatcc      840

ctgcctggcc ttatcggttg ccaccggaag tccgtgtatt ggcatgtgat cggcatggga      900

accactccag aggtgcactc cattttcttg gaggggcata ccttcttggt gcgcaaccac      960

agacaggcct ccctggaaat ttctccgatc actttcctga ctgcccagac cctccttatg     1020

gacctgggtc agttcctgct gttctgccac atttcgtccc accaacacga tggcatggaa     1080

gcctacgtga aagtggactc gtgcccggaa gaaccacagc tgcggatgaa gaacaacgaa     1140

gaggcagagg actacgatga tgatcttacc gattcggaaa tggatgtggt ccgattcgac     1200

gacgataata gcccatcctt catccaaatt aggagcgtgg ccaagaagca ccccaaaact     1260

tgggtgcatt acattgcggc cgaggaagag gattgggact acgcacccct cgtgcttgca     1320

cccgatgatc ggtcctacaa gtcccaatac ctgaacaacg gcccgcagag gatcggtcgg     1380

aagtataaga aagtgcgctt catggcctac accgacgaga ctttcaagac cagagaggcc     1440

attcagcacg aaagcggcat tctggggccg ctgttgtacg gggaggtcgg agatacactg     1500

ctcatcattt tcaagaacca ggcgtccaga ccctacaaca tctacccgca cggaatcact     1560

gacgtccgcc ccctgtactc ccggagactc ccgaagggag tcaagcactt gaaagacttc     1620

cccatcctgc ctggggaaat cttcaagtac aagtggaccg tgaccgtcga ggatgggccg     1680

accaagtccg atccaagatg cctcactaga tactactcat ccttcgtcaa catggaacgg     1740

gacctggcct caggactgat tggccccctg ctcatctgct acaaggagtc cgtggatcag     1800

cgcggaaacc agatcatgtc ggacaaacgc aacgtcatcc tcttctccgt ctttgacgag     1860

aaccgctcat ggtaccttac ggagaacatc cagcggttcc tccccaaccc tgccggagtg     1920

cagctcgagg acccggaatt ccaggcatca aacattatgc actccatcaa cggttacgtg     1980

ttcgacagcc tccagcttag cgtgtgcctc catgaagtcg catattggta catcctgtcc     2040

attggagcac aaaccgactt tctctccgtg ttcttctccg gatatacctt caagcacaag     2100

atggtgtacg aggataccct gaccctcttc cccttctccg gagagactgt gtttatgtcg     2160

atggaaaacc caggcctgtg gattttgggg tgccacaact cggatttccg aaaccggggc     2220

atgactgcct tgctcaaggt gtcctcctgt gacaagaaca cgggagacta ctacgaggac     2280

tcctacgagg atatttccgc ctacctcctg tccaagaaca acgccatcga acccaggtcc     2340

ttcagccaga accctcctgt cctcaagcgc catcagagag aaatcacccg cacgaccctg     2400

cagtccgacc aggaagagat cgattacgac gacactatct ccgtcgaaat gaagaaggag     2460

gactttgaca tctacgacga agatgaaaat cagtcccctc gctcgttcca aaagaaaacg     2520

agacactact tcatcgctgc tgtggagcgg ctctgggact acggcatgtc ctcatcgccc     2580

cacgtgctta ggaaccgggc tcaatccggg agcgtccctc agttcaagaa agtggtgttt     2640

caagaattca ccgatggaag cttcacgcag ccgttgtaca ggggcgaact gaacgagcac     2700

cttggcctgc tgggacctta catcagagca gaggtcgagg acaacatcat ggtgaccttc     2760

cggaaccaag cctcccggcc atattcattc tactcgagcc ttatctcata cgaggaggat     2820

cagagacagg gggctgaacc tcggaagaac ttcgtcaagc cgaacgagac aaagacctac     2880

ttttggaagg tgcagcacca catggccccg accaaggatg agttcgactg caaggcctgg     2940

gcgtacttct ccgacgtgga tctcgaaaag gacgtgcatt ccgggctgat cggaccgctg     3000

ctcgtctgcc acactaacac cctcaatcct gctcacggca gacaagtgac cgtgcaggag     3060

ttcgccctgt tcttcaccat cttcgacgaa actaagtcat ggtactttac cgagaacatg     3120

gagcggaatt gtcgggcccc atgtaacatc cagatggagg acccgacatt caaggagaac     3180

taccggttcc acgccattaa cggatacatt atggacactc ttccgggact cgtgatggca     3240

caggaccaac gcatcagatg gtatcttctg tcgatgggga gcaacgaaaa catccattcg     3300

atccacttta gcggtcacgt gttcacagtg cgcaagaagg aagagtacaa gatggcgctg     3360

tacaacctgt accctggggt gttcgagact gtggaaatgc tgccgtccaa ggccggaatt     3420

tggcgcgtgg aatgtctgat cggtgaacat ctgcatgccg gaatgtccac cctgttcctg     3480

gtgtactcca acaagtgcca aaccccactg ggaatggcat caggacacat tagagacttc     3540

cagattaccg cgagcggaca gtacggacaa tgggccccca agttggccag gctgcactac     3600

tctggaagca ttaacgcctg gagcaccaag gagccgttca gctggatcaa ggtggacctt     3660

ctggcgccaa tgatcatcca cggaattaag actcagggag cccgccagaa gttctcatcg     3720

ctctacatct cccagtttat catcatgtac tcactggatg ggaagaagtg gcagacttac     3780

cggggaaatt ccaccggtac tctgatggtg ttcttcggaa acgtggacag ctccggcatc     3840

aagcacaata tctttaaccc gcctatcatc gcccgataca tccggctcca cccgactcac     3900

tactccatcc ggtcgactct gcggatggaa ctcatgggtt gcgacctcaa ctcctgctca     3960

atgccactgg gcatggagtc caaggctatc tcggacgctc agattactgc atcgtcgtac     4020

tttaccaaca tgttcgctac ctggtccccg tccaaagccc ggctgcatct ccaaggcaga     4080

tcaaacgcgt ggaggcctca ggtcaacaac ccgaaggaat ggcttcaggt cgacttccaa     4140

aagaccatga aagtcaccgg agtgaccacc cagggcgtga aatcgctgct gacctctatg     4200

tacgtgaagg aattcctgat ctcatcaagc caggacggcc accagtggac actgttcttc     4260

caaaatggaa aggtcaaggt ctttcaggga aatcaagact ccttcacccc cgtggtgaac     4320

tccctggacc cccctctgct tacccgctac ttgcgcattc atccgcaatc ctgggtgcac     4380

cagatcgccc tgcgaatgga agtgctgggc tgtgaagcgc aggacctgta ctaaaataaa     4440

agatctttat tttcattaga tctgtgtgtt ggttttttgt gtgcgatcgg gaactggcat     4500

cttcagggag tagcttaggt cagtgaagag aagtgccagt tcccgatcgt tacaggccgc     4560

gggccgc                                                               4567


<210>  90
<211>  4567
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<223>  MAB8D

<400>  90
gcggcctaag gcaattgtgc cagttcccga tcgttacagg aactttgagt gtagcagaga       60

ggaaccattg ccaccttcag attttaatgt ctgacctctt ctcttcctcc cacagtggcc      120

accagaaggt actacctagg agccgtggaa ctgagctggg actacatgca gtctgacctg      180

ggagagctgc ccgtggacgc tagatttcct ccaagagtgc ccaagagctt ccccttcaac      240

acctccgtgg tgtacaagaa aaccctgttc gtggaattca ccgaccacct gttcaatatc      300

gccaagccta gacctccttg gatgggcctg ctgggcccta caattcaggc cgaggtgtac      360

gacaccgtgg tcatcaccct gaagaacatg gccagccatc ctgtgtctct gcacgccgtg      420

ggagtgtctt actggaaggc ttctgagggc gccgagtacg acgaccagac aagccagaga      480

gagaaagagg acgacaaggt tttccctggc ggcagccaca cctatgtctg gcaggtcctg      540

aaagaaaacg gccctatggc ctccgatcct ctgtgcctga catacagcta cctgagccat      600

gtggacctgg tcaaggacct gaactctggc ctgatcggcg ctctgctcgt gtgtagagaa      660

ggcagcctgg ccaaagaaaa gacccagaca ctgcacaagt tcatcctgct gttcgccgtg      720

ttcgacgagg gcaagagctg gcacagcgag acaaagaaca gcctgatgca ggacagagat      780

gccgcctctg ctagagcttg gcccaagatg cacaccgtga acggctacgt gaacagaagc      840

ctgcctggac tgatcggatg ccacagaaag tccgtgtact ggcatgtgat cggcatgggc      900

accacacctg aggtgcacag catctttctg gaaggacaca ccttcctcgt gcggaaccac      960

agacaggcca gcctggaaat cagccctatc accttcctga ccgctcagac cctgctgatg     1020

gatctgggcc agtttctgct gttctgccac atcagcagcc accagcacga tggcatggaa     1080

gcctacgtga aggtggacag ctgccccgaa gaaccccagc tgagaatgaa gaacaacgag     1140

gaagccgagg actacgacga cgacctgacc gactctgaga tggacgtcgt cagattcgac     1200

gacgataaca gccccagctt catccagatc agaagcgtgg ccaagaagca ccccaagacc     1260

tgggtgcact atatcgccgc cgaggaagag gactgggatt acgctcctct ggtgctggcc     1320

cctgacgaca gaagctacaa gagccagtac ctgaacaacg gccctcagag aatcggccgg     1380

aagtataaga aagtgcggtt catggcctac accgacgaga cattcaagac cagagaggct     1440

atccagcacg agagcggcat tctgggacct ctgctgtatg gcgaagtggg cgacacactg     1500

ctgatcatct tcaagaacca ggccagcaga ccctacaaca tctaccctca cggcatcacc     1560

gatgtgcggc ctctgtactc tagaaggctg cccaagggcg tgaagcacct gaaggacttc     1620

cctatcctgc ctggcgagat cttcaagtac aagtggaccg tgaccgtcga ggacggccct     1680

accaagagcg atcctagatg cctgacacgg tactacagca gcttcgtgaa catggaacgc     1740

gacctggcca gcggcctgat tggtcctctg ctgatctgct acaaagaaag cgtggaccag     1800

aggggcaacc agatcatgag cgacaagaga aacgtgatcc tgttctccgt ctttgacgag     1860

aacaggtcct ggtatctgac cgagaacatc cagcggtttc tgcccaatcc tgctggcgtg     1920

cagctggaag atcctgagtt ccaggcctcc aacatcatgc actccatcaa cggctatgtg     1980

ttcgacagcc tgcagctgag cgtgtgcctg cacgaagtgg cctactggta catcctgtct     2040

atcggcgccc agaccgactt cctgtccgtg ttctttagcg gctacacctt caagcacaag     2100

atggtgtacg aggataccct gacactgttc ccattcagcg gcgagacagt gttcatgagc     2160

atggaaaacc ccggcctgtg gatcctgggc tgtcacaaca gcgacttcag aaacagaggc     2220

atgacagccc tgctgaaggt gtccagctgc gacaagaaca ccggcgacta ctacgaggac     2280

tcttacgagg acatcagcgc ctacctgctg agcaagaaca atgccatcga gcctcggagc     2340

ttctctcaga accctcctgt gctgaagaga caccagcgcg agatcaccag aaccacactg     2400

cagagcgacc aagaggaaat cgattacgac gacaccatca gcgtcgagat gaagaaagaa     2460

gatttcgaca tctacgacga ggacgagaat cagagcccca gatctttcca gaagaaaacg     2520

cggcactact tcattgccgc cgtggaaaga ctgtgggact acggcatgag cagcagccca     2580

catgtgctga gaaacagggc ccagagcgga agcgtgcccc agttcaagaa agtggtgttc     2640

caagagttca ccgacggcag cttcacccag cctctgtata gaggcgagct gaacgagcac     2700

ctgggactgc tgggacctta catcagagct gaggtcgagg ataacatcat ggtcaccttt     2760

agaaaccagg cctctaggcc ctactccttc tacagctccc tgatcagcta cgaagaggac     2820

cagagacagg gcgctgagcc cagaaagaac ttcgtgaagc ccaacgagac taagacctac     2880

ttttggaagg tgcagcacca catggcccct acaaaggacg agttcgactg caaggcctgg     2940

gcctacttct ctgacgtgga cctcgagaag gatgtgcaca gcggactcat cggacccctg     3000

cttgtgtgcc acaccaacac actgaatccc gctcacggca ggcaagtgac cgtgcaagag     3060

ttcgccctgt tcttcaccat cttcgatgag acaaagtcct ggtacttcac cgaaaacatg     3120

gaaagaaact gcagggcccc ttgcaacatc cagatggaag atcccacctt caaagagaac     3180

taccggttcc acgccatcaa tggctacatc atggacactc tgcccggcct ggttatggca     3240

caggatcaga ggatcagatg gtatctgctg tccatgggct ccaacgagaa tatccacagc     3300

atccacttca gcggccatgt gttcaccgtg cggaaaaaag aagagtacaa gatggccctg     3360

tacaatctgt accccggcgt gttcgagact gtggaaatgc tgcctagcaa ggccggaatc     3420

tggcgcgtgg aatgtctgat cggagagcat ctgcatgccg gaatgtctac cctgttcctg     3480

gtgtacagca acaagtgtca gacccctctc ggcatggcct ctggacacat cagagacttc     3540

cagatcaccg cctctggcca gtacggacag tgggctccta aactggctag actgcactac     3600

agcggcagca tcaacgcctg gtccaccaaa gagcccttca gctggatcaa ggtggacctg     3660

ctggctccca tgatcatcca cggaatcaag acccagggcg ccagacagaa gttcagcagc     3720

ctgtacatca gccagttcat catcatgtac agcctggacg gcaagaagtg gcagacctac     3780

agaggcaaca gcaccggcac actcatggtg ttcttcggca acgtggactc cagcggcatt     3840

aagcacaaca tcttcaaccc tccaatcatt gcccggtaca tccggctgca ccccacacac     3900

tacagcatca gatctaccct gaggatggaa ctgatgggct gcgacctgaa cagctgctct     3960

atgcccctcg gaatggaaag caaggccatc agcgacgccc agatcacagc cagcagctac     4020

ttcaccaaca tgttcgccac atggtcccca tctaaggccc ggctgcatct gcagggcaga     4080

tctaacgctt ggaggcccca agtgaacaac cccaaagagt ggctgcaggt cgactttcag     4140

aaaaccatga aagtgaccgg cgtgaccaca cagggcgtca agtctctgct gacctctatg     4200

tacgtgaaag agttcctgat ctccagcagc caggacggcc accagtggac cctgtttttc     4260

cagaacggca aagtcaaggt gttccaggga aaccaggaca gcttcacacc cgtggtcaac     4320

tccctggatc ctccactgct gaccagatac ctgagaattc accctcagtc ttgggtgcac     4380

cagatcgctc tgagaatgga agtgctggga tgtgaagctc aggacctcta ctaaaataaa     4440

agatctttat tttcattaga tctgtgtgtt ggttttttgt gtgcgatcgg gaactggcat     4500

cttcagggag tagcttaggt cagtgaagag aagtgccagt tcccgatcgt tacaggccgc     4560

gggccgc                                                               4567


<210>  91
<211>  4402
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<223>  MAB8E

<400>  91
aattgctgac ctcttctctt cctcccacag tggccaccag aagatactac ctgggagctg       60

tggaattgag ctgggattac atgcaatctg acctgggaga actgcctgtg gatgccaggt      120

ttcctcctag ggtccccaag tccttcccat tcaacacctc agtggtctac aagaaaaccc      180

tctttgtgga gttcacagac catctgttca acattgccaa gccaagaccc ccatggatgg      240

gactcctggg tccaaccatc caagctgaag tgtatgacac tgtggtcatt accctgaaga      300

acatggcctc ccatcctgtg tccctgcatg cagtgggagt gtcctactgg aaggcttctg      360

aaggggctga gtatgatgat caaaccagcc agagagaaaa ggaggatgac aaagtgttcc      420

caggtggtag tcacacctat gtgtggcaag tgctcaagga gaatggtcct atggcctctg      480

atcccctgtg tctgacctac tcctacctgt cccatgtgga cctggtgaag gatctgaact      540

ctgggctgat tggagccctg ctggtgtgca gagaaggctc cctggccaag gaaaagaccc      600

agacactgca caagttcatc ttgctgtttg ctgtgtttga tgagggaaag tcctggcatt      660

ctgagactaa gaactccctt atgcaagaca gagatgctgc ctcagctagg gcttggccta      720

agatgcatac tgtgaatgga tatgtgaaca gatccctgcc tggccttatt ggttgccaca      780

ggaagtctgt gtattggcat gtgattggca tgggaaccac tccagaggtg cactccattt      840

tcttggaggg gcataccttc ttggtgagga accacagaca ggcctccctg gaaatttctc      900

caatcacttt cctgactgcc cagaccctcc ttatggacct gggtcagttc ctgctgttct      960

gccacatttc atcccaccaa catgatggca tggaagccta tgtgaaagtg gactcatgcc     1020

cagaagaacc acagctgaga atgaagaaca atgaagaggc agaggactat gatgatgatc     1080

ttacagattc agaaatggat gtggtcagat ttgatgatga taatagccca tccttcatcc     1140

aaattaggag tgtggccaag aagcacccca aaacttgggt gcattacatt gcagctgagg     1200

aagaggattg ggactatgca cccttggtgc ttgcaccaga tgataggtcc tacaagtccc     1260

aatacctgaa caatggccca cagaggattg gtagaaagta taagaaagtg agattcatgg     1320

cctacacaga tgagactttc aagaccagag aggccattca gcatgaatct ggcattctgg     1380

ggccactgtt gtatggggag gttggagata cactgctcat cattttcaag aaccaggcct     1440

ccagacccta caacatctac cctcatggaa tcactgatgt cagacccctg tactccagaa     1500

gactcccaaa gggagtcaag cacttgaaag acttccccat cctgcctggg gaaatcttca     1560

agtacaagtg gacagtgaca gtggaggatg ggccaaccaa gtctgatcca agatgcctca     1620

ctagatacta ctcatccttt gtcaacatgg aaagagacct ggcctcagga ctgattggcc     1680

ccctgctcat ctgctacaag gagtctgtgg atcagagagg aaaccagatc atgtctgaca     1740

aaaggaatgt catcctcttc tctgtctttg atgagaacag atcatggtac cttacagaga     1800

acatccagag gttcctcccc aaccctgctg gagtgcagct ggaggaccca gaattccagg     1860

catcaaacat tatgcactcc atcaatggtt atgtgtttga cagcctccag ctttctgtgt     1920

gcctccatga agtggcatat tggtacatcc tgtccattgg agcacaaaca gactttctct     1980

ctgtgttctt ctctggatat accttcaagc acaagatggt gtatgaggat accctgaccc     2040

tcttcccctt ctctggagag actgtgttta tgtcaatgga aaacccaggc ctgtggattt     2100

tggggtgcca caactcagat ttcagaaaca ggggcatgac tgccttgctc aaggtgtcct     2160

cctgtgacaa gaacacagga gactactatg aggactccta tgaggatatt tctgcctacc     2220

tcctgtccaa gaacaatgcc attgaaccca ggtccttcag ccagaaccct cctgtcctca     2280

agaggcatca gagagaaatc accagaacta ccctgcagtc tgaccaggaa gagattgatt     2340

atgatgacac tatctcagtg gaaatgaaga aggaggactt tgacatctat gatgaagatg     2400

aaaatcagtc ccctaggtcc ttccaaaaga aaacaagaca ctacttcatt gctgctgtgg     2460

agagactctg ggactatggc atgtcctcat caccccatgt gcttaggaac agggctcaat     2520

ctgggtctgt ccctcagttc aagaaagtgg tgtttcaaga attcacagat ggaagcttca     2580

cacagccatt gtacagggga gaactgaatg agcaccttgg cctgctggga ccttacatca     2640

gagcagaggt ggaggacaac atcatggtga ccttcagaaa ccaagcctcc aggccatatt     2700

cattctactc cagccttatc tcatatgagg aggatcagag acagggggct gaacctagga     2760

agaactttgt caagccaaat gagacaaaga cctacttttg gaaggtgcag caccacatgg     2820

cccctaccaa ggatgagttt gactgcaagg cctgggctta cttctctgat gtggatctgg     2880

aaaaggatgt gcattctggg ctgattggac ctctgctggt ctgccacact aacaccctca     2940

atcctgctca tggcagacaa gtgacagtgc aggagtttgc cctgttcttc accatctttg     3000

atgaaactaa gtcatggtac tttacagaga acatggagag aaattgtagg gccccatgta     3060

acatccagat ggaggaccca acattcaagg agaactacag attccatgcc attaatggat     3120

acattatgga cactcttcca ggactggtga tggcacagga ccaaagaatc agatggtatc     3180

ttctgagcat ggggagcaat gaaaacatcc attccatcca cttttcaggt catgtgttca     3240

cagtgaggaa gaaggaagag tacaagatgg ctctgtacaa cctgtaccct ggggtgtttg     3300

agactgtgga aatgctgcca tccaaggctg gaatttggag ggtggaatgt ctgattggtg     3360

aacatctgca tgctggaatg tccaccctgt tcctggtgta ctccaacaag tgccaaaccc     3420

cactgggaat ggcatcagga cacattagag acttccagat tacagcatct ggacagtatg     3480

gacaatgggc ccccaagttg gccaggctgc actactctgg aagcattaat gcctggagca     3540

ccaaggagcc attcagctgg atcaaggtgg accttctggc tccaatgatc atccatggaa     3600

ttaagactca gggagccaga cagaagttct catccctcta catctcccag tttatcatca     3660

tgtactcact ggatgggaag aagtggcaga cttacagggg aaattccaca ggtactctga     3720

tggtgttctt tggaaatgtg gacagctctg gcatcaagca caatatcttt aaccctccta     3780

tcattgccag gtacatcaga ctccacccaa ctcactactc catcaggtcc actctgagga     3840

tggaactcat gggttgtgac ctcaactcct gctcaatgcc actgggcatg gagtccaagg     3900

ctatctcaga tgctcagatt actgcatcct cttactttac caacatgttt gctacctggt     3960

ccccctccaa agccagactg catctccaag gcagatcaaa tgcctggagg cctcaggtca     4020

acaacccaaa ggaatggctt caggtggact tccaaaagac catgaaagtc acaggagtga     4080

ccacccaggg agtgaaatcc ctgctgacct ctatgtatgt gaaggaattc ctgatctcat     4140

caagccagga tggccaccag tggacactgt tcttccaaaa tggaaaggtc aaggtctttc     4200

agggaaatca agactccttc acccctgtgg tgaactccct ggacccccct ctgcttacca     4260

ggtacttgag aattcatcca caatcctggg tgcaccagat tgccctgagg atggaagtgc     4320

tgggctgtga agcccaggac ctgtactaaa ataaaagatc tttattttca ttagatctgt     4380

gtgttggttt tttgtgtgcc gc                                              4402


<210>  92
<211>  4419
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<223>  MAB8F (GA co/CpG free)

<400>  92
gctagccaat tgctgacctc ttctcttcct cccacagtgg ccaccagaag gtactacctg       60

ggagctgtgg aactgagctg ggactacatg cagtctgacc tgggagagct gcctgtggat      120

gctagatttc ctccaagagt gcccaagagc ttccccttca acacctctgt ggtgtacaag      180

aaaaccctgt ttgtggaatt cacagaccac ctgttcaata ttgccaagcc tagacctcct      240

tggatgggcc tgctgggccc tacaattcag gctgaggtgt atgacacagt ggtcatcacc      300

ctgaagaaca tggccagcca tcctgtgtct ctgcatgctg tgggagtgtc ttactggaag      360

gcttctgagg gggctgagta tgatgaccag acaagccaga gagagaaaga ggatgacaag      420

gttttccctg ggggcagcca cacctatgtc tggcaggtcc tgaaagaaaa tggccctatg      480

gcctctgatc ctctgtgcct gacatacagc tacctgagcc atgtggacct ggtcaaggac      540

ctgaactctg gcctgattgg ggctctgctg gtgtgtagag aaggcagcct ggccaaagaa      600

aagacccaga cactgcacaa gttcatcctg ctgtttgctg tgtttgatga gggcaagagc      660

tggcactctg agacaaagaa cagcctgatg caggacagag atgctgcctc tgctagagct      720

tggcccaaga tgcacacagt gaatggctat gtgaacagaa gcctgcctgg actgattgga      780

tgccacagaa agtctgtgta ctggcatgtg attggcatgg gcaccacacc tgaggtgcac      840

agcatctttc tggaaggaca caccttcctg gtgaggaacc acagacaggc cagcctggaa      900

atcagcccta tcaccttcct gacagctcag accctgctga tggatctggg ccagtttctg      960

ctgttctgcc acatcagcag ccaccagcat gatggcatgg aagcctatgt gaaggtggac     1020

agctgccctg aagaacccca gctgagaatg aagaacaatg aggaagctga ggactatgat     1080

gatgacctga cagactctga gatggatgtg gtcagatttg atgatgataa cagccccagc     1140

ttcatccaga tcagatctgt ggccaagaag caccccaaga cctgggtgca ctatattgct     1200

gctgaggaag aggactggga ttatgctcct ctggtgctgg cccctgatga cagaagctac     1260

aagagccagt acctgaacaa tggccctcag agaattggca ggaagtataa gaaagtgagg     1320

ttcatggcct acacagatga gacattcaag accagagagg ctatccagca tgagtctggc     1380

attctgggac ctctgctgta tggggaagtg ggggacacac tgctgatcat cttcaagaac     1440

caggccagca gaccctacaa catctaccct catggcatca cagatgtgag gcctctgtac     1500

tctagaaggc tgcccaaggg ggtgaagcac ctgaaggact tccctatcct gcctggggag     1560

atcttcaagt acaagtggac agtgacagtg gaggatggcc ctaccaagtc tgatcctaga     1620

tgcctgacaa ggtactacag cagctttgtg aacatggaaa gggacctggc ctctggcctg     1680

attggtcctc tgctgatctg ctacaaagaa tctgtggacc agaggggcaa ccagatcatg     1740

agtgacaaga gaaatgtgat cctgttctct gtctttgatg agaacaggtc ctggtatctg     1800

acagagaaca tccagaggtt tctgcccaat cctgctgggg tgcagctgga agatcctgag     1860

ttccaggcct ccaacatcat gcactccatc aatggctatg tgtttgacag cctgcagctg     1920

tctgtgtgcc tgcatgaagt ggcctactgg tacatcctgt ctattggggc ccagacagac     1980

ttcctgtctg tgttcttttc tggctacacc ttcaagcaca agatggtgta tgaggatacc     2040

ctgacactgt tcccattctc tggggagaca gtgttcatga gcatggaaaa ccctggcctg     2100

tggatcctgg gctgtcacaa cagtgacttc agaaacagag gcatgacagc cctgctgaag     2160

gtgtccagct gtgacaagaa cactggggac tactatgagg actcttatga ggacatctct     2220

gcctacctgc tgagcaagaa caatgccatt gagcctagga gcttctctca gaaccctcct     2280

gtgctgaaga gacaccagag ggagatcacc agaaccacac tgcagtctga ccaagaggaa     2340

attgattatg atgacaccat ctctgtggag atgaagaaag aagattttga catctatgat     2400

gaggatgaga atcagagccc cagatctttc cagaagaaaa caaggcacta cttcattgct     2460

gctgtggaaa gactgtggga ctatggcatg agcagcagcc cccatgtgct gagaaacagg     2520

gcccagtctg gaagtgtgcc ccagttcaag aaagtggtgt tccaagagtt cacagatggc     2580

agcttcaccc agcctctgta tagaggggag ctgaatgagc acctgggact gctgggacct     2640

tacatcagag ctgaggtgga ggataacatc atggtcacct ttagaaacca ggcctctagg     2700

ccctactcct tctacagctc cctgatcagc tatgaagagg accagagaca gggggctgag     2760

cccagaaaga actttgtgaa gcccaatgag actaagacct acttttggaa ggtgcagcac     2820

cacatggccc ctacaaagga tgagtttgac tgcaaggcct gggcctactt ctctgatgtg     2880

gacctggaga aggatgtgca ctctggactc attggacccc tgcttgtgtg ccacaccaac     2940

acactgaatc ctgctcatgg caggcaagtg acagtgcaag agtttgccct gttcttcacc     3000

atctttgatg agacaaagtc ctggtacttc acagaaaaca tggaaagaaa ctgcagggcc     3060

ccttgcaaca tccagatgga agatcccacc ttcaaagaga actacaggtt ccatgccatc     3120

aatggctaca tcatggacac tctgcctggc ctggttatgg cacaggatca gaggatcaga     3180

tggtatctgc tgtccatggg ctccaatgag aatatccaca gcatccactt ctctggccat     3240

gtgttcacag tgaggaaaaa agaagagtac aagatggccc tgtacaatct gtaccctggg     3300

gtgtttgaga ctgtggaaat gctgcctagc aaggctggaa tctggagggt ggaatgtctg     3360

attggagagc atctgcatgc tggaatgtct accctgttcc tggtgtacag caacaagtgt     3420

cagacccctc tgggcatggc ctctggacac atcagagact tccagatcac agcctctggc     3480

cagtatggac agtgggctcc taaactggct agactgcact actctggcag catcaatgcc     3540

tggtccacca aagagccctt cagctggatc aaggtggacc tgctggctcc catgatcatc     3600

catggaatca agacccaggg ggccagacag aagttcagca gcctgtacat cagccagttc     3660

atcatcatgt acagcctgga tggcaagaag tggcagacct acagaggcaa cagcacaggc     3720

acactcatgg tgttctttgg caatgtggac tcttctggca ttaagcacaa catcttcaac     3780

cctccaatca ttgccaggta catcaggctg caccccacac actacagcat cagatctacc     3840

ctgaggatgg aactgatggg ctgtgacctg aacagctgct ctatgcccct gggaatggaa     3900

agcaaggcca tctctgatgc ccagatcaca gccagcagct acttcaccaa catgtttgcc     3960

acatggtccc catctaaggc caggctgcat ctgcagggca gatctaatgc ttggaggccc     4020

caagtgaaca accccaaaga gtggctgcag gtggactttc agaaaaccat gaaagtgaca     4080

ggagtgacca cacagggggt caagtctctg ctgacctcta tgtatgtgaa agagttcctg     4140

atctccagca gccaggatgg ccaccagtgg accctgtttt tccagaatgg caaagtcaag     4200

gtgttccagg gaaaccagga cagcttcaca cctgtggtca actccctgga tcctccactg     4260

ctgaccagat acctgagaat tcaccctcag tcttgggtgc accagattgc tctgagaatg     4320

gaagtgctgg gatgtgaagc tcaggacctc tactaaaata aaagatcttt attttcatta     4380

gatctgtgtg ttggtttttt gtgtgccgcg ggtttaaac                            4419


<210>  93
<211>  4314
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide

<220>
<221>  misc_feature
<223>  codon optimized mature FVIII-BDD coding sequence

<220>
<221>  misc_feature
<223>  F8-BDD1, codon optimized

<400>  93
gccaccagaa gatactacct cggagccgtc gaattgagct gggattacat gcaatccgac       60

ctgggagaac tgcccgtgga tgccaggttt cctcctcggg tccccaagtc cttcccgttc      120

aacacctcag tcgtctacaa gaaaaccctc ttcgtggagt tcaccgacca tctgttcaac      180

atcgccaagc caagaccccc gtggatggga ctcctcggtc cgaccatcca agccgaagtg      240

tacgacactg tggtcattac cctgaagaac atggcctccc atcctgtgtc cctgcatgca      300

gtgggcgtgt cctactggaa ggcttccgaa ggggccgagt acgacgatca aaccagccag      360

cgggaaaagg aggatgacaa agtgttcccg ggtggttcgc acacctacgt gtggcaagtg      420

ctcaaggaga acggtcctat ggcctctgat cccctgtgtc tgacctactc ctacctgtcc      480

catgtcgacc tcgtgaagga tctgaacagc gggctgattg gcgccctgct cgtgtgccgg      540

gaaggctccc tggccaagga aaagacccag acactgcaca agttcatctt gctgttcgcc      600

gtgtttgatg agggaaagtc ctggcatagc gagactaaga actcccttat gcaagaccgg      660

gatgctgcct ccgctagggc ttggcctaag atgcatactg tgaacggata cgtgaacaga      720

tccctgcctg gccttatcgg ttgccaccgg aagtccgtgt attggcatgt gatcggcatg      780

ggaaccactc cagaggtgca ctccattttc ttggaggggc ataccttctt ggtgcgcaac      840

cacagacagg cctccctgga aatttctccg atcactttcc tgactgccca gaccctcctt      900

atggacctgg gtcagttcct gctgttctgc cacatttcgt cccaccaaca cgatggcatg      960

gaagcctacg tgaaagtgga ctcgtgcccg gaagaaccac agctgcggat gaagaacaac     1020

gaagaggcag aggactacga tgatgatctt accgattcgg aaatggatgt ggtccgattc     1080

gacgacgata atagcccatc cttcatccaa attaggagcg tggccaagaa gcaccccaaa     1140

acttgggtgc attacattgc ggccgaggaa gaggattggg actacgcacc cctcgtgctt     1200

gcacccgatg atcggtccta caagtcccaa tacctgaaca acggcccgca gaggatcggt     1260

cggaagtata agaaagtgcg cttcatggcc tacaccgacg agactttcaa gaccagagag     1320

gccattcagc acgaaagcgg cattctgggg ccgctgttgt acggggaggt cggagataca     1380

ctgctcatca ttttcaagaa ccaggcgtcc agaccctaca acatctaccc gcacggaatc     1440

actgacgtcc gccccctgta ctcccggaga ctcccgaagg gagtcaagca cttgaaagac     1500

ttccccatcc tgcctgggga aatcttcaag tacaagtgga ccgtgaccgt cgaggatggg     1560

ccgaccaagt ccgatccaag atgcctcact agatactact catccttcgt caacatggaa     1620

cgggacctgg cctcaggact gattggcccc ctgctcatct gctacaagga gtccgtggat     1680

cagcgcggaa accagatcat gtcggacaaa cgcaacgtca tcctcttctc cgtctttgac     1740

gagaaccgct catggtacct tacggagaac atccagcggt tcctccccaa ccctgccgga     1800

gtgcagctcg aggacccgga attccaggca tcaaacatta tgcactccat caacggttac     1860

gtgttcgaca gcctccagct tagcgtgtgc ctccatgaag tcgcatattg gtacatcctg     1920

tccattggag cacaaaccga ctttctctcc gtgttcttct ccggatatac cttcaagcac     1980

aagatggtgt acgaggatac cctgaccctc ttccccttct ccggagagac tgtgtttatg     2040

tcgatggaaa acccaggcct gtggattttg gggtgccaca actcggattt ccgaaaccgg     2100

ggcatgactg ccttgctcaa ggtgtcctcc tgtgacaaga acacgggaga ctactacgag     2160

gactcctacg aggatatttc cgcctacctc ctgtccaaga acaacgccat cgaacccagg     2220

tccttcagcc agaaccctcc tgtcctcaag cgccatcaga gagaaatcac ccgcacgacc     2280

ctgcagtccg accaggaaga gatcgattac gacgacacta tctccgtcga aatgaagaag     2340

gaggactttg acatctacga cgaagatgaa aatcagtccc ctcgctcgtt ccaaaagaaa     2400

acgagacact acttcatcgc tgctgtggag cggctctggg actacggcat gtcctcatcg     2460

ccccacgtgc ttaggaaccg ggctcaatcc gggagcgtcc ctcagttcaa gaaagtggtg     2520

tttcaagaat tcaccgatgg aagcttcacg cagccgttgt acaggggcga actgaacgag     2580

caccttggcc tgctgggacc ttacatcaga gcagaggtcg aggacaacat catggtgacc     2640

ttccggaacc aagcctcccg gccatattca ttctactcga gccttatctc atacgaggag     2700

gatcagagac agggggctga acctcggaag aacttcgtca agccgaacga gacaaagacc     2760

tacttttgga aggtgcagca ccacatggcc ccgaccaagg atgagttcga ctgcaaggcc     2820

tgggcgtact tctccgacgt ggatctcgaa aaggacgtgc attccgggct gatcggaccg     2880

ctgctcgtct gccacactaa caccctcaat cctgctcacg gcagacaagt gaccgtgcag     2940

gagttcgccc tgttcttcac catcttcgac gaaactaagt catggtactt taccgagaac     3000

atggagcgga attgtcgggc cccatgtaac atccagatgg aggacccgac attcaaggag     3060

aactaccggt tccacgccat taacggatac attatggaca ctcttccggg actcgtgatg     3120

gcacaggacc aacgcatcag atggtatctt ctgtcgatgg ggagcaacga aaacatccat     3180

tcgatccact ttagcggtca cgtgttcaca gtgcgcaaga aggaagagta caagatggcg     3240

ctgtacaacc tgtaccctgg ggtgttcgag actgtggaaa tgctgccgtc caaggccgga     3300

atttggcgcg tggaatgtct gatcggtgaa catctgcatg ccggaatgtc caccctgttc     3360

ctggtgtact ccaacaagtg ccaaacccca ctgggaatgg catcaggaca cattagagac     3420

ttccagatta ccgcgagcgg acagtacgga caatgggccc ccaagttggc caggctgcac     3480

tactctggaa gcattaacgc ctggagcacc aaggagccgt tcagctggat caaggtggac     3540

cttctggcgc caatgatcat ccacggaatt aagactcagg gagcccgcca gaagttctca     3600

tcgctctaca tctcccagtt tatcatcatg tactcactgg atgggaagaa gtggcagact     3660

taccggggaa attccaccgg tactctgatg gtgttcttcg gaaacgtgga cagctccggc     3720

atcaagcaca atatctttaa cccgcctatc atcgcccgat acatccggct ccacccgact     3780

cactactcca tccggtcgac tctgcggatg gaactcatgg gttgcgacct caactcctgc     3840

tcaatgccac tgggcatgga gtccaaggct atctcggacg ctcagattac tgcatcgtcg     3900

tactttacca acatgttcgc tacctggtcc ccgtccaaag cccggctgca tctccaaggc     3960

agatcaaacg cgtggaggcc tcaggtcaac aacccgaagg aatggcttca ggtcgacttc     4020

caaaagacca tgaaagtcac cggagtgacc acccagggcg tgaaatcgct gctgacctct     4080

atgtacgtga aggaattcct gatctcatca agccaggacg gccaccagtg gacactgttc     4140

ttccaaaatg gaaaggtcaa ggtctttcag ggaaatcaag actccttcac ccccgtggtg     4200

aactccctgg acccccctct gcttacccgc tacttgcgca ttcatccgca atcctgggtg     4260

caccagatcg ccctgcgaat ggaagtgctg ggctgtgaag cgcaggacct gtac           4314


<210>  94
<211>  4443
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide

<220>
<221>  misc_feature
<223>  codon optimized mature FVIII-BDD coding sequence

<220>
<221>  misc_feature
<223>  F8-BDD2, codon optimized

<400>  94
gccaccagaa ggtactacct aggagccgtg gaactgagct gggactacat gcagtctgac       60

ctgggagagc tgcccgtgga cgctagattt cctccaagag tgcccaagag cttccccttc      120

aacacctccg tggtgtacaa gaaaaccctg ttcgtggaat tcaccgacca cctgttcaat      180

atcgccaagc ctagacctcc ttggatgggc ctgctgggcc ctacaattca ggccgaggtg      240

tacgacaccg tggtcatcac cctgaagaac atggccagcc atcctgtgtc tctgcacgcc      300

gtgggagtgt cttactggaa ggcttctgag ggcgccgagt acgacgacca gacaagccag      360

agagagaaag aggacgacaa ggttttccct ggcggcagcc acacctatgt ctggcaggtc      420

ctgaaagaaa acggccctat ggcctccgat cctctgtgcc tgacatacag ctacctgagc      480

catgtggacc tggtcaagga cctgaactct ggcctgatcg gcgctctgct cgtgtgtaga      540

gaaggcagcc tggccaaaga aaagacccag acactgcaca agttcatcct gctgttcgcc      600

gtgttcgacg agggcaagag ctggcacagc gagacaaaga acagcctgat gcaggacaga      660

gatgccgcct ctgctagagc ttggcccaag atgcacaccg tgaacggcta cgtgaacaga      720

agcctgcctg gactgatcgg atgccacaga aagtccgtgt actggcatgt gatcggcatg      780

ggcaccacac ctgaggtgca cagcatcttt ctggaaggac acaccttcct cgtgcggaac      840

cacagacagg ccagcctgga aatcagccct atcaccttcc tgaccgctca gaccctgctg      900

atggatctgg gccagtttct gctgttctgc cacatcagca gccaccagca cgatggcatg      960

gaagcctacg tgaaggtgga cagctgcccc gaagaacccc agctgagaat gaagaacaac     1020

gaggaagccg aggactacga cgacgacctg accgactctg agatggacgt cgtcagattc     1080

gacgacgata acagccccag cttcatccag atcagaagcg tggccaagaa gcaccccaag     1140

acctgggtgc actatatcgc cgccgaggaa gaggactggg attacgctcc tctggtgctg     1200

gcccctgacg acagaagcta caagagccag tacctgaaca acggccctca gagaatcggc     1260

cggaagtata agaaagtgcg gttcatggcc tacaccgacg agacattcaa gaccagagag     1320

gctatccagc acgagagcgg cattctggga cctctgctgt atggcgaagt gggcgacaca     1380

ctgctgatca tcttcaagaa ccaggccagc agaccctaca acatctaccc tcacggcatc     1440

accgatgtgc ggcctctgta ctctagaagg ctgcccaagg gcgtgaagca cctgaaggac     1500

ttccctatcc tgcctggcga gatcttcaag tacaagtgga ccgtgaccgt cgaggacggc     1560

cctaccaaga gcgatcctag atgcctgaca cggtactaca gcagcttcgt gaacatggaa     1620

cgcgacctgg ccagcggcct gattggtcct ctgctgatct gctacaaaga aagcgtggac     1680

cagaggggca accagatcat gagcgacaag agaaacgtga tcctgttctc cgtctttgac     1740

gagaacaggt cctggtatct gaccgagaac atccagcggt ttctgcccaa tcctgctggc     1800

gtgcagctgg aagatcctga gttccaggcc tccaacatca tgcactccat caacggctat     1860

gtgttcgaca gcctgcagct gagcgtgtgc ctgcacgaag tggcctactg gtacatcctg     1920

tctatcggcg cccagaccga cttcctgtcc gtgttcttta gcggctacac cttcaagcac     1980

aagatggtgt acgaggatac cctgacactg ttcccattca gcggcgagac agtgttcatg     2040

agcatggaaa accccggcct gtggatcctg ggctgtcaca acagcgactt cagaaacaga     2100

ggcatgacag ccctgctgaa ggtgtccagc tgcgacaaga acaccggcga ctactacgag     2160

gactcttacg aggacatcag cgcctacctg ctgagcaaga acaatgccat cgagcctcgg     2220

agcttctctc agaaccctcc tgtgctgaag agacaccagc gcgagatcac cagaaccaca     2280

ctgcagagcg accaagagga aatcgattac gacgacacca tcagcgtcga gatgaagaaa     2340

gaagatttcg acatctacga cgaggacgag aatcagagcc ccagatcttt ccagaagaaa     2400

acgcggcact acttcattgc cgccgtggaa agactgtggg actacggcat gagcagcagc     2460

ccacatgtgc tgagaaacag ggcccagagc ggaagcgtgc cccagttcaa gaaagtggtg     2520

ttccaagagt tcaccgacgg cagcttcacc cagcctctgt atagaggcga gctgaacgag     2580

cacctgggac tgctgggacc ttacatcaga gctgaggtcg aggataacat catggtcacc     2640

tttagaaacc aggcctctag gccctactcc ttctacagct ccctgatcag ctacgaagag     2700

gaccagagac agggcgctga gcccagaaag aacttcgtga agcccaacga gactaagacc     2760

tacttttgga aggtgcagca ccacatggcc cctacaaagg acgagttcga ctgcaaggcc     2820

tgggcctact tctctgacgt ggacctcgag aaggatgtgc acagcggact catcggaccc     2880

ctgcttgtgt gccacaccaa cacactgaat cccgctcacg gcaggcaagt gaccgtgcaa     2940

gagttcgccc tgttcttcac catcttcgat gagacaaagt cctggtactt caccgaaaac     3000

atggaaagaa actgcagggc cccttgcaac atccagatgg aagatcccac cttcaaagag     3060

aactaccggt tccacgccat caatggctac atcatggaca ctctgcccgg cctggttatg     3120

gcacaggatc agaggatcag atggtatctg ctgtccatgg gctccaacga gaatatccac     3180

agcatccact tcagcggcca tgtgttcacc gtgcggaaaa aagaagagta caagatggcc     3240

ctgtacaatc tgtaccccgg cgtgttcgag actgtggaaa tgctgcctag caaggccgga     3300

atctggcgcg tggaatgtct gatcggagag catctgcatg ccggaatgtc taccctgttc     3360

ctggtgtaca gcaacaagtg tcagacccct ctcggcatgg cctctggaca catcagagac     3420

ttccagatca ccgcctctgg ccagtacgga cagtgggctc ctaaactggc tagactgcac     3480

tacagcggca gcatcaacgc ctggtccacc aaagagccct tcagctggat caaggtggac     3540

ctgctggctc ccatgatcat ccacggaatc aagacccagg gcgccagaca gaagttcagc     3600

agcctgtaca tcagccagtt catcatcatg tacagcctgg acggcaagaa gtggcagacc     3660

tacagaggca acagcaccgg cacactcatg gtgttcttcg gcaacgtgga ctccagcggc     3720

attaagcaca acatcttcaa ccctccaatc attgcccggt acatccggct gcaccccaca     3780

cactacagca tcagatctac cctgaggatg gaactgatgg gctgcgacct gaacagctgc     3840

tctatgcccc tcggaatgga aagcaaggcc atcagcgacg cccagatcac agccagcagc     3900

tacttcacca acatgttcgc cacatggtcc ccatctaagg cccggctgca tctgcagggc     3960

agatctaacg cttggaggcc ccaagtgaac aaccccaaag agtggctgca ggtcgacttt     4020

cagaaaacca tgaaagtgac cggcgtgacc acacagggcg tcaagtctct gctgacctct     4080

atgtacgtga aagagttcct gatctccagc agccaggacg gccaccagtg gaccctgttt     4140

ttccagaacg gcaaagtcaa ggtgttccag ggaaaccagg acagcttcac acccgtggtc     4200

aactccctgg atcctccact gctgaccaga tacctgagaa ttcaccctca gtcttgggtg     4260

caccagatcg ctctgagaat ggaagtgctg ggatgtgaag ctcaggacct ctactaaaat     4320

aaaagatctt tattttcatt agatctgtgt gttggttttt tgtgtgcgat cgggaactgg     4380

catcttcagg gagtagctta ggtcagtgaa gagaagtgcc agttcccgat cgttacaggc     4440

cgc                                                                   4443


<210>  95
<211>  4317
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide

<220>
<221>  misc_feature
<223>  codon optimized mature FVIII-BDD coding sequence

<220>
<221>  misc_feature
<223>  F8-BDD3, codon optimized

<400>  95
gccaccagaa gatactacct gggagctgtg gaattgagct gggattacat gcaatctgac       60

ctgggagaac tgcctgtgga tgccaggttt cctcctaggg tccccaagtc cttcccattc      120

aacacctcag tggtctacaa gaaaaccctc tttgtggagt tcacagacca tctgttcaac      180

attgccaagc caagaccccc atggatggga ctcctgggtc caaccatcca agctgaagtg      240

tatgacactg tggtcattac cctgaagaac atggcctccc atcctgtgtc cctgcatgca      300

gtgggagtgt cctactggaa ggcttctgaa ggggctgagt atgatgatca aaccagccag      360

agagaaaagg aggatgacaa agtgttccca ggtggtagtc acacctatgt gtggcaagtg      420

ctcaaggaga atggtcctat ggcctctgat cccctgtgtc tgacctactc ctacctgtcc      480

catgtggacc tggtgaagga tctgaactct gggctgattg gagccctgct ggtgtgcaga      540

gaaggctccc tggccaagga aaagacccag acactgcaca agttcatctt gctgtttgct      600

gtgtttgatg agggaaagtc ctggcattct gagactaaga actcccttat gcaagacaga      660

gatgctgcct cagctagggc ttggcctaag atgcatactg tgaatggata tgtgaacaga      720

tccctgcctg gccttattgg ttgccacagg aagtctgtgt attggcatgt gattggcatg      780

ggaaccactc cagaggtgca ctccattttc ttggaggggc ataccttctt ggtgaggaac      840

cacagacagg cctccctgga aatttctcca atcactttcc tgactgccca gaccctcctt      900

atggacctgg gtcagttcct gctgttctgc cacatttcat cccaccaaca tgatggcatg      960

gaagcctatg tgaaagtgga ctcatgccca gaagaaccac agctgagaat gaagaacaat     1020

gaagaggcag aggactatga tgatgatctt acagattcag aaatggatgt ggtcagattt     1080

gatgatgata atagcccatc cttcatccaa attaggagtg tggccaagaa gcaccccaaa     1140

acttgggtgc attacattgc agctgaggaa gaggattggg actatgcacc cttggtgctt     1200

gcaccagatg ataggtccta caagtcccaa tacctgaaca atggcccaca gaggattggt     1260

agaaagtata agaaagtgag attcatggcc tacacagatg agactttcaa gaccagagag     1320

gccattcagc atgaatctgg cattctgggg ccactgttgt atggggaggt tggagataca     1380

ctgctcatca ttttcaagaa ccaggcctcc agaccctaca acatctaccc tcatggaatc     1440

actgatgtca gacccctgta ctccagaaga ctcccaaagg gagtcaagca cttgaaagac     1500

ttccccatcc tgcctgggga aatcttcaag tacaagtgga cagtgacagt ggaggatggg     1560

ccaaccaagt ctgatccaag atgcctcact agatactact catcctttgt caacatggaa     1620

agagacctgg cctcaggact gattggcccc ctgctcatct gctacaagga gtctgtggat     1680

cagagaggaa accagatcat gtctgacaaa aggaatgtca tcctcttctc tgtctttgat     1740

gagaacagat catggtacct tacagagaac atccagaggt tcctccccaa ccctgctgga     1800

gtgcagctgg aggacccaga attccaggca tcaaacatta tgcactccat caatggttat     1860

gtgtttgaca gcctccagct ttctgtgtgc ctccatgaag tggcatattg gtacatcctg     1920

tccattggag cacaaacaga ctttctctct gtgttcttct ctggatatac cttcaagcac     1980

aagatggtgt atgaggatac cctgaccctc ttccccttct ctggagagac tgtgtttatg     2040

tcaatggaaa acccaggcct gtggattttg gggtgccaca actcagattt cagaaacagg     2100

ggcatgactg ccttgctcaa ggtgtcctcc tgtgacaaga acacaggaga ctactatgag     2160

gactcctatg aggatatttc tgcctacctc ctgtccaaga acaatgccat tgaacccagg     2220

tccttcagcc agaaccctcc tgtcctcaag aggcatcaga gagaaatcac cagaactacc     2280

ctgcagtctg accaggaaga gattgattat gatgacacta tctcagtgga aatgaagaag     2340

gaggactttg acatctatga tgaagatgaa aatcagtccc ctaggtcctt ccaaaagaaa     2400

acaagacact acttcattgc tgctgtggag agactctggg actatggcat gtcctcatca     2460

ccccatgtgc ttaggaacag ggctcaatct gggtctgtcc ctcagttcaa gaaagtggtg     2520

tttcaagaat tcacagatgg aagcttcaca cagccattgt acaggggaga actgaatgag     2580

caccttggcc tgctgggacc ttacatcaga gcagaggtgg aggacaacat catggtgacc     2640

ttcagaaacc aagcctccag gccatattca ttctactcca gccttatctc atatgaggag     2700

gatcagagac agggggctga acctaggaag aactttgtca agccaaatga gacaaagacc     2760

tacttttgga aggtgcagca ccacatggcc cctaccaagg atgagtttga ctgcaaggcc     2820

tgggcttact tctctgatgt ggatctggaa aaggatgtgc attctgggct gattggacct     2880

ctgctggtct gccacactaa caccctcaat cctgctcatg gcagacaagt gacagtgcag     2940

gagtttgccc tgttcttcac catctttgat gaaactaagt catggtactt tacagagaac     3000

atggagagaa attgtagggc cccatgtaac atccagatgg aggacccaac attcaaggag     3060

aactacagat tccatgccat taatggatac attatggaca ctcttccagg actggtgatg     3120

gcacaggacc aaagaatcag atggtatctt ctgagcatgg ggagcaatga aaacatccat     3180

tccatccact tttcaggtca tgtgttcaca gtgaggaaga aggaagagta caagatggct     3240

ctgtacaacc tgtaccctgg ggtgtttgag actgtggaaa tgctgccatc caaggctgga     3300

atttggaggg tggaatgtct gattggtgaa catctgcatg ctggaatgtc caccctgttc     3360

ctggtgtact ccaacaagtg ccaaacccca ctgggaatgg catcaggaca cattagagac     3420

ttccagatta cagcatctgg acagtatgga caatgggccc ccaagttggc caggctgcac     3480

tactctggaa gcattaatgc ctggagcacc aaggagccat tcagctggat caaggtggac     3540

cttctggctc caatgatcat ccatggaatt aagactcagg gagccagaca gaagttctca     3600

tccctctaca tctcccagtt tatcatcatg tactcactgg atgggaagaa gtggcagact     3660

tacaggggaa attccacagg tactctgatg gtgttctttg gaaatgtgga cagctctggc     3720

atcaagcaca atatctttaa ccctcctatc attgccaggt acatcagact ccacccaact     3780

cactactcca tcaggtccac tctgaggatg gaactcatgg gttgtgacct caactcctgc     3840

tcaatgccac tgggcatgga gtccaaggct atctcagatg ctcagattac tgcatcctct     3900

tactttacca acatgtttgc tacctggtcc ccctccaaag ccagactgca tctccaaggc     3960

agatcaaatg cctggaggcc tcaggtcaac aacccaaagg aatggcttca ggtggacttc     4020

caaaagacca tgaaagtcac aggagtgacc acccagggag tgaaatccct gctgacctct     4080

atgtatgtga aggaattcct gatctcatca agccaggatg gccaccagtg gacactgttc     4140

ttccaaaatg gaaaggtcaa ggtctttcag ggaaatcaag actccttcac ccctgtggtg     4200

aactccctgg acccccctct gcttaccagg tacttgagaa ttcatccaca atcctgggtg     4260

caccagattg ccctgaggat ggaagtgctg ggctgtgaag cccaggacct gtactaa        4317


<210>  96
<211>  4314
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide

<220>
<221>  misc_feature
<223>  codon optimized mature FVIII-BDD coding sequence

<220>
<221>  misc_feature
<223>  F8-BDD4, codon optimized

<400>  96
gccaccagaa ggtactacct gggagctgtg gaactgagct gggactacat gcagtctgac       60

ctgggagagc tgcctgtgga tgctagattt cctccaagag tgcccaagag cttccccttc      120

aacacctctg tggtgtacaa gaaaaccctg tttgtggaat tcacagacca cctgttcaat      180

attgccaagc ctagacctcc ttggatgggc ctgctgggcc ctacaattca ggctgaggtg      240

tatgacacag tggtcatcac cctgaagaac atggccagcc atcctgtgtc tctgcatgct      300

gtgggagtgt cttactggaa ggcttctgag ggggctgagt atgatgacca gacaagccag      360

agagagaaag aggatgacaa ggttttccct gggggcagcc acacctatgt ctggcaggtc      420

ctgaaagaaa atggccctat ggcctctgat cctctgtgcc tgacatacag ctacctgagc      480

catgtggacc tggtcaagga cctgaactct ggcctgattg gggctctgct ggtgtgtaga      540

gaaggcagcc tggccaaaga aaagacccag acactgcaca agttcatcct gctgtttgct      600

gtgtttgatg agggcaagag ctggcactct gagacaaaga acagcctgat gcaggacaga      660

gatgctgcct ctgctagagc ttggcccaag atgcacacag tgaatggcta tgtgaacaga      720

agcctgcctg gactgattgg atgccacaga aagtctgtgt actggcatgt gattggcatg      780

ggcaccacac ctgaggtgca cagcatcttt ctggaaggac acaccttcct ggtgaggaac      840

cacagacagg ccagcctgga aatcagccct atcaccttcc tgacagctca gaccctgctg      900

atggatctgg gccagtttct gctgttctgc cacatcagca gccaccagca tgatggcatg      960

gaagcctatg tgaaggtgga cagctgccct gaagaacccc agctgagaat gaagaacaat     1020

gaggaagctg aggactatga tgatgacctg acagactctg agatggatgt ggtcagattt     1080

gatgatgata acagccccag cttcatccag atcagatctg tggccaagaa gcaccccaag     1140

acctgggtgc actatattgc tgctgaggaa gaggactggg attatgctcc tctggtgctg     1200

gcccctgatg acagaagcta caagagccag tacctgaaca atggccctca gagaattggc     1260

aggaagtata agaaagtgag gttcatggcc tacacagatg agacattcaa gaccagagag     1320

gctatccagc atgagtctgg cattctggga cctctgctgt atggggaagt gggggacaca     1380

ctgctgatca tcttcaagaa ccaggccagc agaccctaca acatctaccc tcatggcatc     1440

acagatgtga ggcctctgta ctctagaagg ctgcccaagg gggtgaagca cctgaaggac     1500

ttccctatcc tgcctgggga gatcttcaag tacaagtgga cagtgacagt ggaggatggc     1560

cctaccaagt ctgatcctag atgcctgaca aggtactaca gcagctttgt gaacatggaa     1620

agggacctgg cctctggcct gattggtcct ctgctgatct gctacaaaga atctgtggac     1680

cagaggggca accagatcat gagtgacaag agaaatgtga tcctgttctc tgtctttgat     1740

gagaacaggt cctggtatct gacagagaac atccagaggt ttctgcccaa tcctgctggg     1800

gtgcagctgg aagatcctga gttccaggcc tccaacatca tgcactccat caatggctat     1860

gtgtttgaca gcctgcagct gtctgtgtgc ctgcatgaag tggcctactg gtacatcctg     1920

tctattgggg cccagacaga cttcctgtct gtgttctttt ctggctacac cttcaagcac     1980

aagatggtgt atgaggatac cctgacactg ttcccattct ctggggagac agtgttcatg     2040

agcatggaaa accctggcct gtggatcctg ggctgtcaca acagtgactt cagaaacaga     2100

ggcatgacag ccctgctgaa ggtgtccagc tgtgacaaga acactgggga ctactatgag     2160

gactcttatg aggacatctc tgcctacctg ctgagcaaga acaatgccat tgagcctagg     2220

agcttctctc agaaccctcc tgtgctgaag agacaccaga gggagatcac cagaaccaca     2280

ctgcagtctg accaagagga aattgattat gatgacacca tctctgtgga gatgaagaaa     2340

gaagattttg acatctatga tgaggatgag aatcagagcc ccagatcttt ccagaagaaa     2400

acaaggcact acttcattgc tgctgtggaa agactgtggg actatggcat gagcagcagc     2460

ccccatgtgc tgagaaacag ggcccagtct ggaagtgtgc cccagttcaa gaaagtggtg     2520

ttccaagagt tcacagatgg cagcttcacc cagcctctgt atagagggga gctgaatgag     2580

cacctgggac tgctgggacc ttacatcaga gctgaggtgg aggataacat catggtcacc     2640

tttagaaacc aggcctctag gccctactcc ttctacagct ccctgatcag ctatgaagag     2700

gaccagagac agggggctga gcccagaaag aactttgtga agcccaatga gactaagacc     2760

tacttttgga aggtgcagca ccacatggcc cctacaaagg atgagtttga ctgcaaggcc     2820

tgggcctact tctctgatgt ggacctggag aaggatgtgc actctggact cattggaccc     2880

ctgcttgtgt gccacaccaa cacactgaat cctgctcatg gcaggcaagt gacagtgcaa     2940

gagtttgccc tgttcttcac catctttgat gagacaaagt cctggtactt cacagaaaac     3000

atggaaagaa actgcagggc cccttgcaac atccagatgg aagatcccac cttcaaagag     3060

aactacaggt tccatgccat caatggctac atcatggaca ctctgcctgg cctggttatg     3120

gcacaggatc agaggatcag atggtatctg ctgtccatgg gctccaatga gaatatccac     3180

agcatccact tctctggcca tgtgttcaca gtgaggaaaa aagaagagta caagatggcc     3240

ctgtacaatc tgtaccctgg ggtgtttgag actgtggaaa tgctgcctag caaggctgga     3300

atctggaggg tggaatgtct gattggagag catctgcatg ctggaatgtc taccctgttc     3360

ctggtgtaca gcaacaagtg tcagacccct ctgggcatgg cctctggaca catcagagac     3420

ttccagatca cagcctctgg ccagtatgga cagtgggctc ctaaactggc tagactgcac     3480

tactctggca gcatcaatgc ctggtccacc aaagagccct tcagctggat caaggtggac     3540

ctgctggctc ccatgatcat ccatggaatc aagacccagg gggccagaca gaagttcagc     3600

agcctgtaca tcagccagtt catcatcatg tacagcctgg atggcaagaa gtggcagacc     3660

tacagaggca acagcacagg cacactcatg gtgttctttg gcaatgtgga ctcttctggc     3720

attaagcaca acatcttcaa ccctccaatc attgccaggt acatcaggct gcaccccaca     3780

cactacagca tcagatctac cctgaggatg gaactgatgg gctgtgacct gaacagctgc     3840

tctatgcccc tgggaatgga aagcaaggcc atctctgatg cccagatcac agccagcagc     3900

tacttcacca acatgtttgc cacatggtcc ccatctaagg ccaggctgca tctgcagggc     3960

agatctaatg cttggaggcc ccaagtgaac aaccccaaag agtggctgca ggtggacttt     4020

cagaaaacca tgaaagtgac aggagtgacc acacaggggg tcaagtctct gctgacctct     4080

atgtatgtga aagagttcct gatctccagc agccaggatg gccaccagtg gaccctgttt     4140

ttccagaatg gcaaagtcaa ggtgttccag ggaaaccagg acagcttcac acctgtggtc     4200

aactccctgg atcctccact gctgaccaga tacctgagaa ttcaccctca gtcttgggtg     4260

caccagattg ctctgagaat ggaagtgctg ggatgtgaag ctcaggacct ctac           4314


<210>  97
<211>  4314
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<223>  Native FVIII-BDD mature CDS

<400>  97
gccaccagaa gatactacct gggtgcagtg gaactgtcat gggactatat gcaaagtgat       60

ctcggtgagc tgcctgtgga cgcaagattt cctcctagag tgccaaaatc ttttccattc      120

aacacctcag tcgtgtacaa aaagactctg tttgtagaat tcacggttca ccttttcaac      180

atcgctaagc caaggccacc ctggatgggt ctgctaggtc ctaccatcca ggctgaggtt      240

tatgatacag tggtcattac acttaagaac atggcttccc atcctgtcag tcttcatgct      300

gttggtgtat cctactggaa agcttctgag ggagctgaat atgatgatca gaccagtcaa      360

agggagaaag aagatgataa agtcttccct ggtggaagcc atacatatgt ctggcaggtc      420

ctgaaagaga atggtccaat ggcctctgac ccactgtgcc ttacctactc atatctttct      480

catgtggacc tggtaaaaga cttgaattca ggcctcattg gagccctact agtatgtaga      540

gaagggagtc tggccaagga aaagacacag accttgcaca aatttatact actttttgct      600

gtatttgatg aagggaaaag ttggcactca gaaacaaaga actccttgat gcaggatagg      660

gatgctgcat ctgctcgggc ctggcctaaa atgcacacag tcaatggtta tgtaaacagg      720

tctctgccag gtctgattgg atgccacagg aaatcagtct attggcatgt gattggaatg      780

ggcaccactc ctgaagtgca ctcaatattc ctcgaaggtc acacatttct tgtgaggaac      840

catcgccagg cgtccttgga aatctcgcca ataactttcc ttactgctca aacactcttg      900

atggaccttg gacagtttct actgttttgt catatctctt cccaccaaca tgatggcatg      960

gaagcttatg tcaaagtaga cagctgtcca gaggaacccc aactacgaat gaaaaataat     1020

gaagaagcgg aagactatga tgatgatctt actgattctg aaatggatgt ggtcaggttt     1080

gatgatgaca actctccttc ctttatccaa attcgctcag ttgccaagaa gcatcctaaa     1140

acttgggtac attacattgc tgctgaagag gaggactggg actatgctcc cttagtcctc     1200

gcccccgatg acagaagtta taaaagtcaa tatttgaaca atggccctca gcggattggt     1260

aggaagtaca aaaaagtccg atttatggca tacacagatg aaacctttaa gactcgtgaa     1320

gctattcagc atgaatcagg aatcttggga cctttacttt atggggaagt tggagacaca     1380

ctgttgatta tatttaagaa tcaagcaagc agaccatata acatctaccc tcacggaatc     1440

actgatgtcc gtcctttgta ttcaaggaga ttaccaaaag gtgtaaaaca tttgaaggat     1500

tttccaattc tgccaggaga aatattcaaa tataaatgga cagtgactgt agaagatggg     1560

ccaactaaat cagatcctcg gtgcctgacc cgctattact ctagtttcgt taatatggag     1620

agagatctag cttcaggact cattggccct ctcctcatct gctacaaaga atctgtagat     1680

caaagaggaa accagataat gtcagacaag aggaatgtca tcctgttttc tgtatttgat     1740

gagaaccgaa gctggtacct cacagagaat atacaacgct ttctccccaa tccagctgga     1800

gtgcagcttg aggatccaga gttccaagcc tccaacatca tgcacagcat caatggctat     1860

gtttttgata gtttgcagtt gtcagtttgt ttgcatgagg tggcatactg gtacattcta     1920

agcattggag cacagactga cttcctttct gtcttcttct ctggatatac cttcaaacac     1980

aaaatggtct atgaagacac actcacccta ttcccattct caggagaaac tgtcttcatg     2040

tcgatggaaa acccaggtct atggattctg gggtgccaca actcagactt tcggaacaga     2100

ggcatgaccg ccttactgaa ggtttctagt tgtgacaaga acactggtga ttattacgag     2160

gacagttatg aagatatttc agcatacttg ctgagtaaaa acaatgccat tgaaccaaga     2220

agcttctccc agaatccacc agtcttgaaa cgccatcaac gggaaataac tcgtactact     2280

cttcagtcag atcaagagga aattgactat gatgatacca tatcagttga aatgaagaag     2340

gaagattttg acatttatga tgaggatgaa aatcagagcc cccgcagctt tcaaaagaaa     2400

acacgacact attttattgc tgcagtggag aggctctggg attatgggat gagtagctcc     2460

ccacatgttc taagaaacag ggctcagagt ggcagtgtcc ctcagttcaa gaaagttgtt     2520

ttccaggaat ttactgatgg ctcctttact cagcccttat accgtggaga actaaatgaa     2580

catttgggac tcctggggcc atatataaga gcagaagttg aagataatat catggtaact     2640

ttcagaaatc aggcctctcg tccctattcc ttctattcta gccttatttc ttatgaggaa     2700

gatcagaggc aaggagcaga acctagaaaa aactttgtca agcctaatga aaccaaaact     2760

tacttttgga aagtgcaaca tcatatggca cccactaaag atgagtttga ctgcaaagcc     2820

tgggcttatt tctctgatgt tgacctggaa aaagatgtgc actcaggcct gattggaccc     2880

cttctggtct gccacactaa cacactgaac cctgctcatg ggagacaagt gacagtacag     2940

gaatttgctc tgtttttcac catctttgat gagaccaaaa gctggtactt cactgaaaat     3000

atggaaagaa actgcagggc tccctgcaat atccagatgg aagatcccac ttttaaagag     3060

aattatcgct tccatgcaat caatggctac ataatggata cactacctgg cttagtaatg     3120

gctcaggatc aaaggattcg atggtatctg ctcagcatgg gcagcaatga aaacatccat     3180

tctattcatt tcagtggaca tgtgttcact gtacgaaaaa aagaggagta taaaatggca     3240

ctgtacaatc tctatccagg tgtttttgag acagtggaaa tgttaccatc caaagctgga     3300

atttggcggg tggaatgcct tattggcgag catctacatg ctgggatgag cacacttttt     3360

ctggtgtaca gcaataagtg tcagactccc ctgggaatgg cttctggaca cattagagat     3420

tttcagatta cagcttcagg acaatatgga cagtgggccc caaagctggc cagacttcat     3480

tattccggat caatcaatgc ctggagcacc aaggagccct tttcttggat caaggtggat     3540

ctgttggcac caatgattat tcacggcatc aagacccagg gtgcccgtca gaagttctcc     3600

agcctctaca tctctcagtt tatcatcatg tatagtcttg atgggaagaa gtggcagact     3660

tatcgaggaa attccactgg aaccttaatg gtcttctttg gcaatgtgga ttcatctggg     3720

ataaaacaca atatttttaa ccctccaatt attgctcgat acatccgttt gcacccaact     3780

cattatagca ttcgcagcac tcttcgcatg gagttgatgg gctgtgattt aaatagttgc     3840

agcatgccat tgggaatgga gagtaaagca atatcagatg cacagattac tgcttcatcc     3900

tactttacca atatgtttgc cacctggtct ccttcaaaag ctcgacttca cctccaaggg     3960

aggagtaatg cctggagacc tcaggtgaat aatccaaaag agtggctgca agtggacttc     4020

cagaagacaa tgaaagtcac aggagtaact actcagggag taaaatctct gcttaccagc     4080

atgtatgtga aggagttcct catctccagc agtcaagatg gccatcagtg gactctcttt     4140

tttcagaatg gcaaagtaaa ggtttttcag ggaaatcaag actccttcac acctgtggtg     4200

aactctctag acccaccgtt actgactcgc taccttcgaa ttcaccccca gagttgggtg     4260

caccagattg ccctgaggat ggaggttctg ggctgcgagg cacaggacct ctac           4314


<210>  98
<211>  9
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide

<400>  98

Asp Ala His Ala Thr Arg Arg Tyr Tyr 
1               5                   


<210>  99
<211>  7
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<223>  Branch site consensus sequence

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Y is T or C

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  N is any nucleotide

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  Y is C or T

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  Y is T or C

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  R is A or G

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  Y is C or T

<400>  99
ynyyray                                                                  7


<210>  100
<211>  22
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<223>  target nucleic acid sequence

<220>
<221>  misc_feature
<222>  (1)..(20)
<223>  N is any nucleotide

<220>
<221>  misc_feature
<222>  (21)..(21)
<223>  R is G or A

<400>  100
nnnnnnnnnn nnnnnnnnnn rg                                                22


<210>  101
<211>  8
<212>  DNA
<213>  Neisseria meningitidis


<220>
<221>  misc_feature
<223>  Neisseria meningitidis PAM

<220>
<221>  misc_feature
<222>  (1)..(4)
<223>  N is any nucleotide

<400>  101
nnnngatt                                                                 8


<210>  102
<211>  9
<212>  DNA
<213>  Neisseria meningitidis


<220>
<221>  misc_feature
<223>  Neisseria meningitidis PAM

<220>
<221>  misc_feature
<222>  (1)..(5)
<223>  N is any nucleotide

<400>  102
nnnnngttt                                                                9


<210>  103
<211>  8
<212>  DNA
<213>  Neisseria meningitidis


<220>
<221>  misc_feature
<223>  Neisseria meningitidis PAM

<220>
<221>  misc_feature
<222>  (1)..(4)
<223>  N is any nucleotide

<400>  103
nnnngctt                                                                 8


<210>  104
<211>  23
<212>  DNA
<213>  Homo sapiens


<220>
<221>  misc_feature
<223>  Human Albumin Intron-1_T25

<400>  104
accttttttt ttttttacct agg                                               23


<210>  105
<211>  1296
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide

<220>
<221>  misc_feature
<223>  codon optimized FIX coding sequence

<400>  105
ttcctcgacc acgagaacgc caacaagatc ctgaacagac ccaagcggta caacagcggc       60

aagctggaag agttcgtgca gggcaacctg gaacgcgagt gcatggaaga gaagtgcagc      120

ttcgaagagg ccagagaggt gttcgagaac accgagagaa ccaccgagtt ctggaagcag      180

tacgtggacg gcgaccagtg cgagagcaat ccttgtctga atggcggcag ctgcaaggac      240

gacatcaaca gctacgagtg ctggtgccct ttcggcttcg agggcaagaa ttgcgagctg      300

gacgtgacct gcaacatcaa gaacggcaga tgcgagcagt tctgcaagaa cagcgccgac      360

aacaaggtcg tgtgctcctg tacagagggc tacagactgg ccgagaacca gaagtcttgc      420

gagcctgccg tgccttttcc atgtggcaga gtgtctgtgt cccagaccag caagctgacc      480

agagccgaga cagtgttccc cgatgtggac tacgtgaaca gcaccgaggc cgagacaatc      540

ctggacaaca tcacccagag cacccagtcc ttcaacgact tcacaagagt cgtcggcggc      600

gaggatgcca aacctggaca gtttccttgg caagtggtgc tgaatggcaa ggtggacgcc      660

ttttgtggcg gctccatcgt gaacgagaag tggattgtga ccgccgctca ctgtgtggaa      720

accggcgtga aaattacagt ggtggccggc gagcacaaca tcgaggaaac agagcacacc      780

gagcagaaac ggaacgtgat cagaatcatc cctcaccaca actacaacgc cgccatcaac      840

aagtacaacc acgatatcgc cctgctggaa ctggacgagc ctctcgtgct gaatagctac      900

gtgaccccta tctgtatcgc cgacaaagag tacaccaaca tctttctgaa gttcggcagc      960

ggctacgtgt ccggctgggg aagagttttc cacaagggaa gatctgccct ggtgctgcag     1020

tacctgagag tgcctctggt ggatagagcc acctgtctga gaagcaccaa gttcaccatc     1080

tacaacaaca tgttctgcgc cggcttccac gaaggcggca gagattcttg tcaaggcgat     1140

tctggcggcc ctcacgtgac agaggtggaa ggcacaagct ttctgaccgg catcatcagc     1200

tggggcgaag agtgtgccat gaaggggaag tacggcatct acaccaaggt gtccagatac     1260

gtgaactgga tcaaagaaaa gaccaagctc acctga                               1296


<210>  106
<211>  1437
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide

<220>
<221>  misc_feature
<223>  SERPING1 coding sequence

<400>  106
aaccccaacg ccaccagcag cagctctcag gatccagagt ctctgcagga cagaggcgag       60

ggcaaagtgg ccacaaccgt gatcagcaag atgctgttcg tggaacccat cctggaagtg      120

tccagcctgc ctaccaccaa cagcacaaca aacagcgcca ccaagatcac cgccaacacc      180

accgatgagc ctaccacaca gcctacaacc gagccaacca ctcagcccac tatccagcct      240

acacagccaa ctacacagct gcccacagac agcccaactc agccaacaac aggcagcttc      300

tgccctggac ctgtgacact gtgtagcgac ctggaaagcc actctacaga ggccgttctg      360

ggagatgccc tggtggattt cagcctgaag ctgtaccacg ccttcagcgc catgaagaaa      420

gtggaaacaa acatggcctt cagtcccttc agcattgcca gcctgctgac acaggttctg      480

ctcggagctg gcgagaacac caagaccaac ctggaatcta tcctgagcta ccccaaggac      540

ttcacatgcg tgcaccaggc tctgaagggc ttcaccacaa agggcgtgac aagcgtgtcc      600

cagatcttcc actctcctga cctggccatc agagacacct tcgtgaacgc cagcagaacc      660

ctgtacagca gctcccctag agtgctgagc aacaacagcg acgctaacct ggaactgatc      720

aacacctggg tcgccaagaa cacaaacaac aagatcagca gactgctgga cagcctgcca      780

agcgacacaa gactggtgct gctgaacgcc atctacctga gcgccaagtg gaaaaccaca      840

ttcgacccca agaaaaccag gatggaaccc ttccacttca agaacagcgt gatcaaggtg      900

cccatgatga acagcaagaa ataccccgtg gctcacttca tcgatcagac cctgaaggct      960

aaagtgggcc agctccagct gagccacaac ctgtctctgg ttatcctggt gcctcagaac     1020

ctgaagcaca ggctggaaga tatggaacag gccctgtctc ctagcgtgtt caaggccatc     1080

atggaaaagc tggaaatgag caagttccag ccaacactgc tgaccctgcc tagaatcaaa     1140

gtgaccacca gccaggacat gctgagcatt atggaaaaac tcgaattctt cgacttcagc     1200

tacgacctga acctgtgcgg cctgacagag gaccctgatc tgcaagtgtc tgccatgcag     1260

catcagaccg tgctggaact caccgagaca ggcgttgaag ctgccgccgc ttctgctatc     1320

tctgtggcta gaaccctgct ggtgttcgag gtgcagcagc ctttcctgtt cgtgctgtgg     1380

gatcagcagc ataagttccc cgtgttcatg ggcagagtgt acgaccctag agcctga        1437


<210>  107
<211>  18
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide

<220>
<221>  misc_feature
<223>  18-bp random sequence

<400>  107
cggtactcct caaagcgt                                                     18


<210>  108
<211>  28
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide

<220>
<221>  misc_feature
<223>  hFIX splice acceptor

<400>  108
actaaagaat tattctttta catttcag                                          28


<210>  109
<211>  2705
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide

<220>
<221>  misc_feature
<223>  Stuffer fragment derived from human micro-satellite sequence

<400>  109
ggatccgccc aggtttaaac gcgcggctgc agaaagtgtg tttctaaact gctacatcgc       60

aaggaatgct cagctctgtg agttcaactc aatcatccca aagaattttc tgagaaagct      120

tctgtcttct ttttatagga agttatttcc tttactacgg tactcctcaa agagtgcaat      180

gatccccttg cagtttctac aaaaagagtg tttcaaacct gaactatcaa agaaaggttc      240

cacactgtga gttgaatgca gacatcacga agaaggttct gagagtgctt ctgtttagtt      300

ctgtgcagtt tatcccgttt ccaacgaaat gctcagagag gaccaaatat ccacttgcag      360

tttctacaaa aagagtgttt caaagctgaa ctatcaaaga aaggttcagc actgtgagtt      420

gaatgcaaac atcacgaaga gggttctgag aatgcttctg tttagttctg tgcgggttat      480

cccgtttcca acgaaatcct cagagcggtc caaatatcta cttgcagttt ctacagaaag      540

accgtttcaa acctgaacta tcaaagaaag gttcaacact gtgagttgaa tgcaaacatc      600

acgaagaagg ttctgagaat gcttctgttt agttctgtgc ggtttatccc gtttccaacg      660

aaatcctcag agaggcctaa atatccactt gcacattcta caaatagtgt gtttcgaaac      720

tgctccatcc aaaggaatgt tcagctctgt gagttaaact cagtcgtcac caagagtttt      780

ctgtgaatgc tactgtctag cttttatatg aagctatttc ctttactacc ataggcctaa      840

agcggtccat atctccactt gcagattcta cacaaagaga gtttccaaac tgctctgtca      900

aagggaatgt tcaactctgt gacttgaatg caatcatcac aaagtagttt ctgagaatgc      960

ttctatctag cttttacggg aagataattc cttttccacc acaggcctca aagccctcca     1020

aatgtccact tgcagattct ggaaaaagag tgtttcaaag cttctctctc gaaaggaaag     1080

ttcaactctg tgagttgaat gcaagcatca caaagaagtt tctgagaatg cttctgttta     1140

gctttcctgt gaagattctc ccgtttccaa cgaaatcttc aaaaaggtcc aaatatccac     1200

ttgcagattc cacacaaaga gtgattggaa actgctcttt gaaaaggaac cttcaactct     1260

gtgagttgaa tgcaatcatc acaaagaagt ttctgacaat gcttctctcc agtttttatg     1320

tgaccataat tcgttttcca ccacaggcct gaaagcgctc caaatgtcca cttgtagaca     1380

ctacgaaaag catgtttcag aactactcta tgaaaagcaa tgtgaaactc tgggagttga     1440

acacaaacat cacagagaag tttctgagaa tgcttctgtt tagtttttat gtgaagatat     1500

tcccgtttcc aaagacatct tcggagaggt ccacatatcc acttgcagat tccacaaaaa     1560

gagagtttca acactgctct atccatagga gggttcaact ctgtgagttg aatgcaatca     1620

tcacagagaa gtttctgaga aggcttctgt ctagatttta tgcgaagata tacccgtttc     1680

gaacgaaggc cacagagtgg tccaaatatc cacttgcaga tcctacaaaa agagtgtttc     1740

aaacctgaac tatcaaagga aggttcaact ctgggatttg aatgcaaaca tcaccaagaa     1800

gtttctgaga atgcttccgt ttagttaggt gcagttatcc cgtttccaac gaaatcctca     1860

gagaggtcca aatatccact tgtagattgt acaaaaagag tgtctcaaac ctgctccatc     1920

caaaggaatg ttcagctctg tgagttaaac tcaatcatca caaagtattt tctgagaatg     1980

cttctgtcta gtttttctat gaagctattc cctttactac cataggcctc aaagcgctcc     2040

aaatctccac ttgcacattc cacaacaaga gtgtttccaa actgctctat caataggaat     2100

gttcaactct gtgaggtgaa tgcaatcatc acaaagcagt ttctgagaat gcttctatct     2160

agtatttagg tgaagatatt tccttttcca ccacaaacca caaagccctc caaacgtcca     2220

cttgcagatt ctagaaaaag agtgtttcat agctgctctt tccaaaggaa agttcaactc     2280

tgggagttga atacaaacat caccaaaaag ttcctgagaa tgcatctgtg tagtttttat     2340

gtgaagatga ttccgtttcc aacgaaatct tcaaagaggt ctacatgtcc ccttgcagat     2400

gccacagaaa gagagtttca aaactgcgct ctcaaaagga gagttcaact ccgtgagttg     2460

aatgcagtca tcacagagaa gcttctgagg atgcttctgt ctagatggca tgtgaagata     2520

tacccgtttc gaacgaagga cacagagtgg tccaaatatc cacttgtaga tcctgcaaaa     2580

agagtgtttc aaacgtgaac tttgaaagga aagttcaact cggggatttg aatgcaaaca     2640

tcacaaagaa gattctgaga ctgcttctgt ttagtcagct gaaattatcc cgtttccaac     2700

gaatt                                                                 2705


<210>  110
<211>  1400
<212>  PRT
<213>  Streptococcus pyogenes

<220>
<221>  misc_feature
<223>  Cas9 endonuclease

<400>  110

Met Ala Pro Lys Lys Lys Arg Lys Val Gly Ile His Gly Val Pro Ala 
1               5                   10                  15      


Ala Asp Lys Lys Tyr Ser Ile Gly Leu Asp Ile Gly Thr Asn Ser Val 
            20                  25                  30          


Gly Trp Ala Val Ile Thr Asp Glu Tyr Lys Val Pro Ser Lys Lys Phe 
        35                  40                  45              


Lys Val Leu Gly Asn Thr Asp Arg His Ser Ile Lys Lys Asn Leu Ile 
    50                  55                  60                  


Gly Ala Leu Leu Phe Asp Ser Gly Glu Thr Ala Glu Ala Thr Arg Leu 
65                  70                  75                  80  


Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg Arg Lys Asn Arg Ile Cys 
                85                  90                  95      


Tyr Leu Gln Glu Ile Phe Ser Asn Glu Met Ala Lys Val Asp Asp Ser 
            100                 105                 110         


Phe Phe His Arg Leu Glu Glu Ser Phe Leu Val Glu Glu Asp Lys Lys 
        115                 120                 125             


His Glu Arg His Pro Ile Phe Gly Asn Ile Val Asp Glu Val Ala Tyr 
    130                 135                 140                 


His Glu Lys Tyr Pro Thr Ile Tyr His Leu Arg Lys Lys Leu Val Asp 
145                 150                 155                 160 


Ser Thr Asp Lys Ala Asp Leu Arg Leu Ile Tyr Leu Ala Leu Ala His 
                165                 170                 175     


Met Ile Lys Phe Arg Gly His Phe Leu Ile Glu Gly Asp Leu Asn Pro 
            180                 185                 190         


Asp Asn Ser Asp Val Asp Lys Leu Phe Ile Gln Leu Val Gln Thr Tyr 
        195                 200                 205             


Asn Gln Leu Phe Glu Glu Asn Pro Ile Asn Ala Ser Gly Val Asp Ala 
    210                 215                 220                 


Lys Ala Ile Leu Ser Ala Arg Leu Ser Lys Ser Arg Arg Leu Glu Asn 
225                 230                 235                 240 


Leu Ile Ala Gln Leu Pro Gly Glu Lys Lys Asn Gly Leu Phe Gly Asn 
                245                 250                 255     


Leu Ile Ala Leu Ser Leu Gly Leu Thr Pro Asn Phe Lys Ser Asn Phe 
            260                 265                 270         


Asp Leu Ala Glu Asp Ala Lys Leu Gln Leu Ser Lys Asp Thr Tyr Asp 
        275                 280                 285             


Asp Asp Leu Asp Asn Leu Leu Ala Gln Ile Gly Asp Gln Tyr Ala Asp 
    290                 295                 300                 


Leu Phe Leu Ala Ala Lys Asn Leu Ser Asp Ala Ile Leu Leu Ser Asp 
305                 310                 315                 320 


Ile Leu Arg Val Asn Thr Glu Ile Thr Lys Ala Pro Leu Ser Ala Ser 
                325                 330                 335     


Met Ile Lys Arg Tyr Asp Glu His His Gln Asp Leu Thr Leu Leu Lys 
            340                 345                 350         


Ala Leu Val Arg Gln Gln Leu Pro Glu Lys Tyr Lys Glu Ile Phe Phe 
        355                 360                 365             


Asp Gln Ser Lys Asn Gly Tyr Ala Gly Tyr Ile Asp Gly Gly Ala Ser 
    370                 375                 380                 


Gln Glu Glu Phe Tyr Lys Phe Ile Lys Pro Ile Leu Glu Lys Met Asp 
385                 390                 395                 400 


Gly Thr Glu Glu Leu Leu Val Lys Leu Asn Arg Glu Asp Leu Leu Arg 
                405                 410                 415     


Lys Gln Arg Thr Phe Asp Asn Gly Ser Ile Pro His Gln Ile His Leu 
            420                 425                 430         


Gly Glu Leu His Ala Ile Leu Arg Arg Gln Glu Asp Phe Tyr Pro Phe 
        435                 440                 445             


Leu Lys Asp Asn Arg Glu Lys Ile Glu Lys Ile Leu Thr Phe Arg Ile 
    450                 455                 460                 


Pro Tyr Tyr Val Gly Pro Leu Ala Arg Gly Asn Ser Arg Phe Ala Trp 
465                 470                 475                 480 


Met Thr Arg Lys Ser Glu Glu Thr Ile Thr Pro Trp Asn Phe Glu Glu 
                485                 490                 495     


Val Val Asp Lys Gly Ala Ser Ala Gln Ser Phe Ile Glu Arg Met Thr 
            500                 505                 510         


Asn Phe Asp Lys Asn Leu Pro Asn Glu Lys Val Leu Pro Lys His Ser 
        515                 520                 525             


Leu Leu Tyr Glu Tyr Phe Thr Val Tyr Asn Glu Leu Thr Lys Val Lys 
    530                 535                 540                 


Tyr Val Thr Glu Gly Met Arg Lys Pro Ala Phe Leu Ser Gly Glu Gln 
545                 550                 555                 560 


Lys Lys Ala Ile Val Asp Leu Leu Phe Lys Thr Asn Arg Lys Val Thr 
                565                 570                 575     


Val Lys Gln Leu Lys Glu Asp Tyr Phe Lys Lys Ile Glu Cys Phe Asp 
            580                 585                 590         


Ser Val Glu Ile Ser Gly Val Glu Asp Arg Phe Asn Ala Ser Leu Gly 
        595                 600                 605             


Thr Tyr His Asp Leu Leu Lys Ile Ile Lys Asp Lys Asp Phe Leu Asp 
    610                 615                 620                 


Asn Glu Glu Asn Glu Asp Ile Leu Glu Asp Ile Val Leu Thr Leu Thr 
625                 630                 635                 640 


Leu Phe Glu Asp Arg Glu Met Ile Glu Glu Arg Leu Lys Thr Tyr Ala 
                645                 650                 655     


His Leu Phe Asp Asp Lys Val Met Lys Gln Leu Lys Arg Arg Arg Tyr 
            660                 665                 670         


Thr Gly Trp Gly Arg Leu Ser Arg Lys Leu Ile Asn Gly Ile Arg Asp 
        675                 680                 685             


Lys Gln Ser Gly Lys Thr Ile Leu Asp Phe Leu Lys Ser Asp Gly Phe 
    690                 695                 700                 


Ala Asn Arg Asn Phe Met Gln Leu Ile His Asp Asp Ser Leu Thr Phe 
705                 710                 715                 720 


Lys Glu Asp Ile Gln Lys Ala Gln Val Ser Gly Gln Gly Asp Ser Leu 
                725                 730                 735     


His Glu His Ile Ala Asn Leu Ala Gly Ser Pro Ala Ile Lys Lys Gly 
            740                 745                 750         


Ile Leu Gln Thr Val Lys Val Val Asp Glu Leu Val Lys Val Met Gly 
        755                 760                 765             


Arg His Lys Pro Glu Asn Ile Val Ile Glu Met Ala Arg Glu Asn Gln 
    770                 775                 780                 


Thr Thr Gln Lys Gly Gln Lys Asn Ser Arg Glu Arg Met Lys Arg Ile 
785                 790                 795                 800 


Glu Glu Gly Ile Lys Glu Leu Gly Ser Gln Ile Leu Lys Glu His Pro 
                805                 810                 815     


Val Glu Asn Thr Gln Leu Gln Asn Glu Lys Leu Tyr Leu Tyr Tyr Leu 
            820                 825                 830         


Gln Asn Gly Arg Asp Met Tyr Val Asp Gln Glu Leu Asp Ile Asn Arg 
        835                 840                 845             


Leu Ser Asp Tyr Asp Val Asp His Ile Val Pro Gln Ser Phe Leu Lys 
    850                 855                 860                 


Asp Asp Ser Ile Asp Asn Lys Val Leu Thr Arg Ser Asp Lys Asn Arg 
865                 870                 875                 880 


Gly Lys Ser Asp Asn Val Pro Ser Glu Glu Val Val Lys Lys Met Lys 
                885                 890                 895     


Asn Tyr Trp Arg Gln Leu Leu Asn Ala Lys Leu Ile Thr Gln Arg Lys 
            900                 905                 910         


Phe Asp Asn Leu Thr Lys Ala Glu Arg Gly Gly Leu Ser Glu Leu Asp 
        915                 920                 925             


Lys Ala Gly Phe Ile Lys Arg Gln Leu Val Glu Thr Arg Gln Ile Thr 
    930                 935                 940                 


Lys His Val Ala Gln Ile Leu Asp Ser Arg Met Asn Thr Lys Tyr Asp 
945                 950                 955                 960 


Glu Asn Asp Lys Leu Ile Arg Glu Val Lys Val Ile Thr Leu Lys Ser 
                965                 970                 975     


Lys Leu Val Ser Asp Phe Arg Lys Asp Phe Gln Phe Tyr Lys Val Arg 
            980                 985                 990         


Glu Ile Asn Asn Tyr His His Ala  His Asp Ala Tyr Leu  Asn Ala Val 
        995                 1000                 1005             


Val Gly  Thr Ala Leu Ile Lys  Lys Tyr Pro Lys Leu  Glu Ser Glu 
    1010                 1015                 1020             


Phe Val  Tyr Gly Asp Tyr Lys  Val Tyr Asp Val Arg  Lys Met Ile 
    1025                 1030                 1035             


Ala Lys  Ser Glu Gln Glu Ile  Gly Lys Ala Thr Ala  Lys Tyr Phe 
    1040                 1045                 1050             


Phe Tyr  Ser Asn Ile Met Asn  Phe Phe Lys Thr Glu  Ile Thr Leu 
    1055                 1060                 1065             


Ala Asn  Gly Glu Ile Arg Lys  Arg Pro Leu Ile Glu  Thr Asn Gly 
    1070                 1075                 1080             


Glu Thr  Gly Glu Ile Val Trp  Asp Lys Gly Arg Asp  Phe Ala Thr 
    1085                 1090                 1095             


Val Arg  Lys Val Leu Ser Met  Pro Gln Val Asn Ile  Val Lys Lys 
    1100                 1105                 1110             


Thr Glu  Val Gln Thr Gly Gly  Phe Ser Lys Glu Ser  Ile Leu Pro 
    1115                 1120                 1125             


Lys Arg  Asn Ser Asp Lys Leu  Ile Ala Arg Lys Lys  Asp Trp Asp 
    1130                 1135                 1140             


Pro Lys  Lys Tyr Gly Gly Phe  Asp Ser Pro Thr Val  Ala Tyr Ser 
    1145                 1150                 1155             


Val Leu  Val Val Ala Lys Val  Glu Lys Gly Lys Ser  Lys Lys Leu 
    1160                 1165                 1170             


Lys Ser  Val Lys Glu Leu Leu  Gly Ile Thr Ile Met  Glu Arg Ser 
    1175                 1180                 1185             


Ser Phe  Glu Lys Asn Pro Ile  Asp Phe Leu Glu Ala  Lys Gly Tyr 
    1190                 1195                 1200             


Lys Glu  Val Lys Lys Asp Leu  Ile Ile Lys Leu Pro  Lys Tyr Ser 
    1205                 1210                 1215             


Leu Phe  Glu Leu Glu Asn Gly  Arg Lys Arg Met Leu  Ala Ser Ala 
    1220                 1225                 1230             


Gly Glu  Leu Gln Lys Gly Asn  Glu Leu Ala Leu Pro  Ser Lys Tyr 
    1235                 1240                 1245             


Val Asn  Phe Leu Tyr Leu Ala  Ser His Tyr Glu Lys  Leu Lys Gly 
    1250                 1255                 1260             


Ser Pro  Glu Asp Asn Glu Gln  Lys Gln Leu Phe Val  Glu Gln His 
    1265                 1270                 1275             


Lys His  Tyr Leu Asp Glu Ile  Ile Glu Gln Ile Ser  Glu Phe Ser 
    1280                 1285                 1290             


Lys Arg  Val Ile Leu Ala Asp  Ala Asn Leu Asp Lys  Val Leu Ser 
    1295                 1300                 1305             


Ala Tyr  Asn Lys His Arg Asp  Lys Pro Ile Arg Glu  Gln Ala Glu 
    1310                 1315                 1320             


Asn Ile  Ile His Leu Phe Thr  Leu Thr Asn Leu Gly  Ala Pro Ala 
    1325                 1330                 1335             


Ala Phe  Lys Tyr Phe Asp Thr  Thr Ile Asp Arg Lys  Arg Tyr Thr 
    1340                 1345                 1350             


Ser Thr  Lys Glu Val Leu Asp  Ala Thr Leu Ile His  Gln Ser Ile 
    1355                 1360                 1365             


Thr Gly  Leu Tyr Glu Thr Arg  Ile Asp Leu Ser Gln  Leu Gly Gly 
    1370                 1375                 1380             


Asp Lys  Arg Pro Ala Ala Thr  Lys Lys Ala Gly Gln  Ala Lys Lys 
    1385                 1390                 1395             


Lys Lys  
    1400 


<210>  111
<211>  1054
<212>  PRT
<213>  Staphylococcus lugdunensis

<220>
<221>  misc_feature
<223>  Cas9 endonuclease

<400>  111

Met Asn Gln Lys Phe Ile Leu Gly Leu Asp Ile Gly Ile Thr Ser Val 
1               5                   10                  15      


Gly Tyr Gly Leu Ile Asp Tyr Glu Thr Lys Asn Ile Ile Asp Ala Gly 
            20                  25                  30          


Val Arg Leu Phe Pro Glu Ala Asn Val Glu Asn Asn Glu Gly Arg Arg 
        35                  40                  45              


Ser Lys Arg Gly Ser Arg Arg Leu Lys Arg Arg Arg Ile His Arg Leu 
    50                  55                  60                  


Glu Arg Val Lys Lys Leu Leu Glu Asp Tyr Asn Leu Leu Asp Gln Ser 
65                  70                  75                  80  


Gln Ile Pro Gln Ser Thr Asn Pro Tyr Ala Ile Arg Val Lys Gly Leu 
                85                  90                  95      


Ser Glu Ala Leu Ser Lys Asp Glu Leu Val Ile Ala Leu Leu His Ile 
            100                 105                 110         


Ala Lys Arg Arg Gly Ile His Lys Ile Asp Val Ile Asp Ser Asn Asp 
        115                 120                 125             


Asp Val Gly Asn Glu Leu Ser Thr Lys Glu Gln Leu Asn Lys Asn Ser 
    130                 135                 140                 


Lys Leu Leu Lys Asp Lys Phe Val Cys Gln Ile Gln Leu Glu Arg Met 
145                 150                 155                 160 


Asn Glu Gly Gln Val Arg Gly Glu Lys Asn Arg Phe Lys Thr Ala Asp 
                165                 170                 175     


Ile Ile Lys Glu Ile Ile Gln Leu Leu Asn Val Gln Lys Asn Phe His 
            180                 185                 190         


Gln Leu Asp Glu Asn Phe Ile Asn Lys Tyr Ile Glu Leu Val Glu Met 
        195                 200                 205             


Arg Arg Glu Tyr Phe Glu Gly Pro Gly Lys Gly Ser Pro Tyr Gly Trp 
    210                 215                 220                 


Glu Gly Asp Pro Lys Ala Trp Tyr Glu Thr Leu Met Gly His Cys Thr 
225                 230                 235                 240 


Tyr Phe Pro Asp Glu Leu Arg Ser Val Lys Tyr Ala Tyr Ser Ala Asp 
                245                 250                 255     


Leu Phe Asn Ala Leu Asn Asp Leu Asn Asn Leu Val Ile Gln Arg Asp 
            260                 265                 270         


Gly Leu Ser Lys Leu Glu Tyr His Glu Lys Tyr His Ile Ile Glu Asn 
        275                 280                 285             


Val Phe Lys Gln Lys Lys Lys Pro Thr Leu Lys Gln Ile Ala Asn Glu 
    290                 295                 300                 


Ile Asn Val Asn Pro Glu Asp Ile Lys Gly Tyr Arg Ile Thr Lys Ser 
305                 310                 315                 320 


Gly Lys Pro Gln Phe Thr Glu Phe Lys Leu Tyr His Asp Leu Lys Ser 
                325                 330                 335     


Val Leu Phe Asp Gln Ser Ile Leu Glu Asn Glu Asp Val Leu Asp Gln 
            340                 345                 350         


Ile Ala Glu Ile Leu Thr Ile Tyr Gln Asp Lys Asp Ser Ile Lys Ser 
        355                 360                 365             


Lys Leu Thr Glu Leu Asp Ile Leu Leu Asn Glu Glu Asp Lys Glu Asn 
    370                 375                 380                 


Ile Ala Gln Leu Thr Gly Tyr Thr Gly Thr His Arg Leu Ser Leu Lys 
385                 390                 395                 400 


Cys Ile Arg Leu Val Leu Glu Glu Gln Trp Tyr Ser Ser Arg Asn Gln 
                405                 410                 415     


Met Glu Ile Phe Thr His Leu Asn Ile Lys Pro Lys Lys Ile Asn Leu 
            420                 425                 430         


Thr Ala Ala Asn Lys Ile Pro Lys Ala Met Ile Asp Glu Phe Ile Leu 
        435                 440                 445             


Ser Pro Val Val Lys Arg Thr Phe Gly Gln Ala Ile Asn Leu Ile Asn 
    450                 455                 460                 


Lys Ile Ile Glu Lys Tyr Gly Val Pro Glu Asp Ile Ile Ile Glu Leu 
465                 470                 475                 480 


Ala Arg Glu Asn Asn Ser Lys Asp Lys Gln Lys Phe Ile Asn Glu Met 
                485                 490                 495     


Gln Lys Lys Asn Glu Asn Thr Arg Lys Arg Ile Asn Glu Ile Ile Gly 
            500                 505                 510         


Lys Tyr Gly Asn Gln Asn Ala Lys Arg Leu Val Glu Lys Ile Arg Leu 
        515                 520                 525             


His Asp Glu Gln Glu Gly Lys Cys Leu Tyr Ser Leu Glu Ser Ile Pro 
    530                 535                 540                 


Leu Glu Asp Leu Leu Asn Asn Pro Asn His Tyr Glu Val Asp His Ile 
545                 550                 555                 560 


Ile Pro Arg Ser Val Ser Phe Asp Asn Ser Tyr His Asn Lys Val Leu 
                565                 570                 575     


Val Lys Gln Ser Glu Asn Ser Lys Lys Ser Asn Leu Thr Pro Tyr Gln 
            580                 585                 590         


Tyr Phe Asn Ser Gly Lys Ser Lys Leu Ser Tyr Asn Gln Phe Lys Gln 
        595                 600                 605             


His Ile Leu Asn Leu Ser Lys Ser Gln Asp Arg Ile Ser Lys Lys Lys 
    610                 615                 620                 


Lys Glu Tyr Leu Leu Glu Glu Arg Asp Ile Asn Lys Phe Glu Val Gln 
625                 630                 635                 640 


Lys Glu Phe Ile Asn Arg Asn Leu Val Asp Thr Arg Tyr Ala Thr Arg 
                645                 650                 655     


Glu Leu Thr Asn Tyr Leu Lys Ala Tyr Phe Ser Ala Asn Asn Met Asn 
            660                 665                 670         


Val Lys Val Lys Thr Ile Asn Gly Ser Phe Thr Asp Tyr Leu Arg Lys 
        675                 680                 685             


Val Trp Lys Phe Lys Lys Glu Arg Asn His Gly Tyr Lys His His Ala 
    690                 695                 700                 


Glu Asp Ala Leu Ile Ile Ala Asn Ala Asp Phe Leu Phe Lys Glu Asn 
705                 710                 715                 720 


Lys Lys Leu Lys Ala Val Asn Ser Val Leu Glu Lys Pro Glu Ile Glu 
                725                 730                 735     


Thr Lys Gln Leu Asp Ile Gln Val Asp Ser Glu Asp Asn Tyr Ser Glu 
            740                 745                 750         


Met Phe Ile Ile Pro Lys Gln Val Gln Asp Ile Lys Asp Phe Arg Asn 
        755                 760                 765             


Phe Lys Tyr Ser His Arg Val Asp Lys Lys Pro Asn Arg Gln Leu Ile 
    770                 775                 780                 


Asn Asp Thr Leu Tyr Ser Thr Arg Lys Lys Asp Asn Ser Thr Tyr Ile 
785                 790                 795                 800 


Val Gln Thr Ile Lys Asp Ile Tyr Ala Lys Asp Asn Thr Thr Leu Lys 
                805                 810                 815     


Lys Gln Phe Asp Lys Ser Pro Glu Lys Phe Leu Met Tyr Gln His Asp 
            820                 825                 830         


Pro Arg Thr Phe Glu Lys Leu Glu Val Ile Met Lys Gln Tyr Ala Asn 
        835                 840                 845             


Glu Lys Asn Pro Leu Ala Lys Tyr His Glu Glu Thr Gly Glu Tyr Leu 
    850                 855                 860                 


Thr Lys Tyr Ser Lys Lys Asn Asn Gly Pro Ile Val Lys Ser Leu Lys 
865                 870                 875                 880 


Tyr Ile Gly Asn Lys Leu Gly Ser His Leu Asp Val Thr His Gln Phe 
                885                 890                 895     


Lys Ser Ser Thr Lys Lys Leu Val Lys Leu Ser Ile Lys Pro Tyr Arg 
            900                 905                 910         


Phe Asp Val Tyr Leu Thr Asp Lys Gly Tyr Lys Phe Ile Thr Ile Ser 
        915                 920                 925             


Tyr Leu Asp Val Leu Lys Lys Asp Asn Tyr Tyr Tyr Ile Pro Glu Gln 
    930                 935                 940                 


Lys Tyr Asp Lys Leu Lys Leu Gly Lys Ala Ile Asp Lys Asn Ala Lys 
945                 950                 955                 960 


Phe Ile Ala Ser Phe Tyr Lys Asn Asp Leu Ile Lys Leu Asp Gly Glu 
                965                 970                 975     


Ile Tyr Lys Ile Ile Gly Val Asn Ser Asp Thr Arg Asn Met Ile Glu 
            980                 985                 990         


Leu Asp Leu Pro Asp Ile Arg Tyr  Lys Glu Tyr Cys Glu  Leu Asn Asn 
        995                 1000                 1005             


Ile Lys  Gly Glu Pro Arg Ile  Lys Lys Thr Ile Gly  Lys Lys Val 
    1010                 1015                 1020             


Asn Ser  Ile Glu Lys Leu Thr  Thr Asp Val Leu Gly  Asn Val Phe 
    1025                 1030                 1035             


Thr Asn  Thr Gln Tyr Thr Lys  Pro Gln Leu Leu Phe  Lys Arg Gly 
    1040                 1045                 1050             


Asn 
    
