                         SEQUENCE LISTING

<110>  Bonumose LLC
 
<120>  Enzymatic Production of Tagatose

<130>  146.0009-WO00

<150>  US 62/747,877
<151>  2018-10-19

<150>  US 62/790,788
<151>  2019-01-10

<160>  12    

<170>  PatentIn version 3.5

<210>  1
<211>  426
<212>  PRT
<213>  Thermanaerothrix daxensis

<400>  1

Met Val Thr Tyr Leu Asp Phe Val Val Leu Ser His Arg Phe Arg Arg 
1               5                   10                  15      


Pro Leu Gly Ile Thr Ser Val Cys Ser Ala His Pro Tyr Val Ile Glu 
            20                  25                  30          


Ala Ala Leu Arg Asn Gly Met Met Thr His Thr Pro Val Leu Ile Glu 
        35                  40                  45              


Ala Thr Cys Asn Gln Val Asn Gln Tyr Gly Gly Tyr Thr Gly Met Thr 
    50                  55                  60                  


Pro Ala Asp Phe Val Arg Tyr Val Glu Asn Ile Ala Ala Arg Val Gly 
65                  70                  75                  80  


Ser Pro Arg Glu Asn Leu Leu Leu Gly Gly Asp His Leu Gly Pro Leu 
                85                  90                  95      


Val Trp Ala His Glu Pro Ala Glu Ser Ala Met Glu Lys Ala Arg Ala 
            100                 105                 110         


Leu Val Lys Ala Tyr Val Glu Ala Gly Phe Arg Lys Ile His Leu Asp 
        115                 120                 125             


Cys Ser Met Pro Cys Ala Asp Asp Arg Asp Phe Ser Pro Lys Val Ile 
    130                 135                 140                 


Ala Glu Arg Ala Ala Glu Leu Ala Gln Val Ala Glu Ser Thr Cys Asp 
145                 150                 155                 160 


Val Met Gly Leu Pro Leu Pro Asn Tyr Val Ile Gly Thr Glu Val Pro 
                165                 170                 175     


Pro Ala Gly Gly Ala Lys Ala Glu Ala Glu Thr Leu Arg Val Thr Arg 
            180                 185                 190         


Pro Glu Asp Ala Ala Glu Thr Ile Ala Leu Thr Arg Ala Ala Phe Phe 
        195                 200                 205             


Lys Arg Gly Leu Glu Ser Ala Trp Glu Arg Val Val Ala Leu Val Val 
    210                 215                 220                 


Gln Pro Gly Val Glu Phe Gly Asp His Gln Ile His Val Tyr Arg Arg 
225                 230                 235                 240 


Glu Glu Ala Gln Ala Leu Ser Arg Phe Ile Glu Ser Gln Pro Gly Leu 
                245                 250                 255     


Val Tyr Glu Ala His Ser Thr Asp Tyr Gln Pro Arg Asp Ala Leu Arg 
            260                 265                 270         


Ala Leu Val Glu Asp His Phe Ala Ile Leu Lys Val Gly Pro Ala Leu 
        275                 280                 285             


Thr Phe Ala Phe Arg Glu Ala Val Phe Ala Leu Ala Ser Ile Glu Asp 
    290                 295                 300                 


Trp Val Cys Asp Ser Pro Ser Arg Ile Leu Glu Val Leu Glu Thr Thr 
305                 310                 315                 320 


Met Leu Ala Asn Pro Val Tyr Trp Gln Lys Tyr Tyr Leu Gly Asp Glu 
                325                 330                 335     


Arg Ala Arg Arg Ile Ala Arg Gly Tyr Ser Phe Ser Asp Arg Ile Arg 
            340                 345                 350         


Tyr Tyr Trp Ser Ala Pro Ala Val Glu Gln Ala Phe Glu Arg Leu Arg 
        355                 360                 365             


Ala Asn Leu Asn Arg Val Ser Ile Pro Leu Val Leu Leu Ser Gln Tyr 
    370                 375                 380                 


Leu Pro Asp Gln Tyr Arg Lys Val Arg Asp Gly Arg Leu Pro Asn Gln 
385                 390                 395                 400 


Phe Asp Ala Leu Ile Leu Asp Lys Ile Gln Ala Val Leu Glu Asp Tyr 
                405                 410                 415     


Asn Val Ala Cys Gly Val Arg Ile Gly Glu 
            420                 425     


<210>  2
<211>  434
<212>  PRT
<213>  Thermoanaerobacterium thermosaccharolyticum

<400>  2

Met Ala Lys Glu His Pro Leu Lys Glu Leu Val Asn Lys Gln Lys Ser 
1               5                   10                  15      


Gly Ile Ser Glu Gly Ile Val Ser Ile Cys Ser Ser Asn Glu Phe Val 
            20                  25                  30          


Ile Glu Ala Ser Met Glu Arg Ala Leu Thr Asn Gly Asp Tyr Val Leu 
        35                  40                  45              


Ile Glu Ser Thr Ala Asn Gln Val Asn Gln Tyr Gly Gly Tyr Ile Gly 
    50                  55                  60                  


Met Thr Pro Ile Glu Phe Lys Lys Phe Val Phe Ser Ile Ala Lys Lys 
65                  70                  75                  80  


Val Asp Phe Pro Leu Asp Lys Leu Ile Leu Gly Gly Asp His Leu Gly 
                85                  90                  95      


Pro Leu Ile Trp Lys Asn Glu Ser Ser Asn Leu Ala Leu Ala Lys Ala 
            100                 105                 110         


Ser Glu Leu Ile Lys Glu Tyr Val Leu Ala Gly Tyr Thr Lys Ile His 
        115                 120                 125             


Ile Asp Thr Ser Met Arg Leu Lys Asp Asp Thr Asp Phe Asn Thr Glu 
    130                 135                 140                 


Ile Ile Ala Gln Arg Ser Ala Val Leu Leu Lys Ala Ala Glu Asn Ala 
145                 150                 155                 160 


Tyr Met Glu Leu Asn Lys Asn Asn Lys Asn Val Leu His Pro Val Tyr 
                165                 170                 175     


Val Ile Gly Ser Glu Val Pro Ile Pro Gly Gly Ser Gln Gly Ser Asp 
            180                 185                 190         


Glu Ser Leu Gln Ile Thr Asp Ala Lys Asp Phe Glu Asn Thr Val Glu 
        195                 200                 205             


Ile Phe Lys Asp Val Phe Ser Lys Tyr Gly Leu Ile Asn Glu Trp Glu 
    210                 215                 220                 


Asn Ile Val Ala Phe Val Val Gln Pro Gly Val Glu Phe Gly Asn Asp 
225                 230                 235                 240 


Phe Val His Glu Tyr Lys Arg Asp Glu Ala Lys Glu Leu Thr Asp Ala 
                245                 250                 255     


Leu Lys Asn Tyr Lys Thr Phe Val Phe Glu Gly His Ser Thr Asp Tyr 
            260                 265                 270         


Gln Thr Arg Glu Ser Leu Lys Gln Met Val Glu Asp Gly Ile Ala Ile 
        275                 280                 285             


Leu Lys Val Gly Pro Ala Leu Thr Phe Ala Leu Arg Glu Ala Leu Ile 
    290                 295                 300                 


Ala Leu Asn Asn Ile Glu Asn Glu Leu Leu Asn Asn Val Asp Ser Ile 
305                 310                 315                 320 


Lys Leu Ser Asn Phe Thr Asn Val Leu Val Ser Glu Met Ile Asn Asn 
                325                 330                 335     


Pro Glu His Trp Lys Asn His Tyr Phe Gly Asp Asp Ala Arg Lys Lys 
            340                 345                 350         


Phe Leu Cys Lys Tyr Ser Tyr Ser Asp Arg Cys Arg Tyr Tyr Leu Pro 
        355                 360                 365             


Thr Arg Asn Val Lys Asn Ser Leu Asn Leu Leu Ile Arg Asn Leu Glu 
    370                 375                 380                 


Asn Val Lys Ile Pro Met Thr Leu Ile Ser Gln Phe Met Pro Leu Gln 
385                 390                 395                 400 


Tyr Asp Asn Ile Arg Arg Gly Leu Ile Lys Asn Glu Pro Ile Ser Leu 
                405                 410                 415     


Ile Lys Asn Ala Ile Met Asn Arg Leu Asn Asp Tyr Tyr Tyr Ala Ile 
            420                 425                 430         


Lys Pro 
        


<210>  3
<211>  220
<212>  PRT
<213>  Methanosarcina thermophila CHTI-55

<400>  3

Met Leu Lys Ala Leu Ile Phe Asp Met Asp Gly Val Leu Val Asp Ser 
1               5                   10                  15      


Met Pro Phe His Ala Ala Ala Trp Lys Lys Ala Phe Phe Glu Met Gly 
            20                  25                  30          


Met Glu Ile Gln Asp Ser Asp Ile Phe Ala Ile Glu Gly Ser Asn Pro 
        35                  40                  45              


Arg Asn Gly Leu Pro Leu Leu Ile Arg Lys Ala Arg Lys Glu Pro Glu 
    50                  55                  60                  


Ala Phe Asp Phe Glu Ala Ile Thr Ser Ile Tyr Arg Gln Glu Phe Lys 
65                  70                  75                  80  


Arg Val Phe Glu Pro Lys Ala Phe Glu Gly Met Lys Glu Cys Leu Glu 
                85                  90                  95      


Val Leu Lys Lys Arg Phe Leu Leu Ser Val Val Ser Gly Ser Asp His 
            100                 105                 110         


Val Ile Val His Ser Ile Ile Asn Arg Leu Phe Pro Gly Ile Phe Asp 
        115                 120                 125             


Ile Val Val Thr Gly Asp Asp Ile Ile Asn Ser Lys Pro His Pro Asp 
    130                 135                 140                 


Pro Phe Leu Lys Ala Val Glu Leu Leu Asn Val Arg Arg Glu Glu Cys 
145                 150                 155                 160 


Val Val Ile Glu Asn Ala Ile Leu Gly Val Glu Ala Ala Lys Asn Ala 
                165                 170                 175     


Arg Ile Tyr Cys Ile Gly Val Pro Thr Tyr Val Glu Pro Ser His Leu 
            180                 185                 190         


Asp Lys Ala Asp Leu Val Val Glu Asp His Arg Gln Leu Met Gln His 
        195                 200                 205             


Leu Leu Ser Leu Glu Pro Ala Asn Gly Phe Arg Gln 
    210                 215                 220 


<210>  4
<211>  213
<212>  PRT
<213>  Thermobispora bispora strain ATCC 19993

<400>  4

Met Asp Val Val Leu Phe Asp Met Asp Gly Leu Leu Val Asp Thr Glu 
1               5                   10                  15      


Arg Leu Trp Phe Ala Val Glu Thr Glu Val Val Glu Arg Leu Gly Gly 
            20                  25                  30          


Ser Trp Gly Pro Glu His Gln Arg Gln Leu Val Gly Gly Ser Leu Lys 
        35                  40                  45              


Arg Ala Val Ala Tyr Met Leu Glu His Thr Gly Ala Asp Val Asp Pro 
    50                  55                  60                  


Asp Val Val Ala Gly Trp Leu Ile Glu Gly Met Glu Arg Arg Leu Thr 
65                  70                  75                  80  


Glu Ser Val Asp Pro Met Pro Gly Ala Met Glu Leu Leu Thr Ala Leu 
                85                  90                  95      


Arg Asp Glu Gly Ile Pro Thr Gly Leu Val Thr Ser Ser Arg Arg Pro 
            100                 105                 110         


Leu Ala Asp Ala Val Leu Lys His Ile Gly Arg Glu His Phe Asp Val 
        115                 120                 125             


Val Val Thr Ala Asp Asp Val Ser His Ala Lys Pro His Pro Glu Pro 
    130                 135                 140                 


Tyr Leu Thr Ala Leu Ala Met Leu Ser Ala Asp Pro Ala Arg Ser Val 
145                 150                 155                 160 


Ala Leu Glu Asp Ser Pro Asn Gly Val Ala Ser Ala Val Ala Ala Gly 
                165                 170                 175     


Cys Arg Val Val Ala Val Pro Ser Leu Leu Pro Ile Pro Glu Gln Pro 
            180                 185                 190         


Gly Val Thr Val Leu Pro Ala Leu Thr His Ala Asp Val Gly Leu Leu 
        195                 200                 205             


Arg Ser Leu Val Gly 
    210             


<210>  5
<211>  237
<212>  PRT
<213>  Spirochaeta thermophila ATCC 49972

<400>  5

Met Arg Lys Arg Arg Glu Cys Ala Pro Pro Gly Ile Arg Ala Ala Ile 
1               5                   10                  15      


Phe Asp Met Asp Gly Thr Leu Val Asn Ser Glu Asp Val Tyr Trp Asp 
            20                  25                  30          


Ala Asp Cys Ala Phe Leu Asp Arg Tyr Gly Ile Pro His Asp Asp Ala 
        35                  40                  45              


Leu Arg Glu Tyr Met Ile Gly Arg Gly Thr Lys Gly Phe Ile Glu Trp 
    50                  55                  60                  


Met Arg Thr Gln Lys Glu Ile Pro Arg Ser Asp Glu Glu Leu Ala Arg 
65                  70                  75                  80  


Glu Lys Met Glu Val Phe Leu Ala His Ala Arg Gly Arg Val Gln Val 
                85                  90                  95      


Phe Pro Glu Met Arg Arg Leu Leu Gly Leu Leu Glu Glu Ala Gly Met 
            100                 105                 110         


Pro Cys Ala Leu Ala Ser Gly Ser Pro Arg Gly Ile Ile Glu Val Leu 
        115                 120                 125             


Leu Glu Glu Thr Gly Leu Ala Gly Phe Phe Arg Val Val Val Ser Ala 
    130                 135                 140                 


Asp Glu Val Ala Arg Pro Lys Pro Ala Pro Asp Val Phe Leu Glu Ala 
145                 150                 155                 160 


Ala Gly Arg Leu Gly Val Glu Pro Gly Gly Cys Val Val Phe Glu Asp 
                165                 170                 175     


Ser Glu Pro Gly Val Arg Ala Gly Leu Asp Ala Gly Met Val Cys Val 
            180                 185                 190         


Ala Ile Pro Thr Leu Val Lys Asp Arg Tyr Pro Glu Val Phe Tyr Gln 
        195                 200                 205             


Ala Asp Val Leu Phe Glu Gly Gly Met Gly Glu Phe Ser Ala Glu Arg 
    210                 215                 220                 


Val Trp Glu Trp Leu Gly Cys Gly Val Gly Val Gly Arg 
225                 230                 235         


<210>  6
<211>  219
<212>  PRT
<213>  Sphaerobacter thermophilus 20745

<400>  6

Met Ser Gln Gly Val Arg Gly Val Val Phe Asp Leu Asp Gly Leu Leu 
1               5                   10                  15      


Val Glu Ser Glu Glu Tyr Trp Glu Gln Ala Arg Arg Glu Phe Val Ser 
            20                  25                  30          


Arg Tyr Gly Gly Thr Trp Gly Asp Asp Ala Gln Gln Ala Val Met Gly 
        35                  40                  45              


Ala Asn Thr Arg Gln Trp Ser Arg Tyr Ile Arg Glu Ala Phe Asp Ile 
    50                  55                  60                  


Pro Leu Thr Glu Glu Glu Ile Ala Ala Ala Val Ile Ala Arg Met Gln 
65                  70                  75                  80  


Glu Leu Tyr His Asp His Leu Pro Leu Leu Pro Gly Ala Ile Pro Ala 
                85                  90                  95      


Val Arg Ala Leu Ala Asp Arg Tyr Pro Leu Ala Val Ala Ser Ser Ser 
            100                 105                 110         


Pro Pro Val Leu Ile Arg Phe Val Leu Ala Glu Met Gly Val Ala Glu 
        115                 120                 125             


Cys Phe Gln Ser Val Thr Ser Ser Asp Glu Val Ala His Gly Lys Pro 
    130                 135                 140                 


Ala Pro Asp Val Tyr His Leu Ala Cys Glu Arg Leu Gly Val Ala Pro 
145                 150                 155                 160 


Glu Gln Ala Val Ala Phe Glu Asp Ser Thr Ala Gly Ile Ala Ala Ala 
                165                 170                 175     


Leu Ala Ala Gly Leu Arg Val Ile Ala Val Pro Asn Arg Ser Tyr Pro 
            180                 185                 190         


Pro Asp Pro Asp Val Leu Arg Arg Ala Asp Leu Thr Leu Pro Ser Leu 
        195                 200                 205             


Glu Glu Phe Asp Pro Ala Val Leu Glu Gln Trp 
    210                 215                 


<210>  7
<211>  424
<212>  PRT
<213>  Candidatus Thermofonsia Clade 3 bacterium

<400>  7

Met Thr Tyr Leu Asp Tyr Leu Thr Ala Ser His His Ser Gly Lys Pro 
1               5                   10                  15      


Ile Gly Leu Ser Ser Ile Cys Ser Ala His Pro Trp Val Leu Arg Thr 
            20                  25                  30          


Ala Leu Gln Gly Glu Arg Pro Val Leu Ile Glu Ser Thr Cys Asn Gln 
        35                  40                  45              


Val Asn Gln Phe Gly Gly Tyr Ser Gly Met Lys Pro Ala Asp Phe Val 
    50                  55                  60                  


Arg Phe Val His Ser Leu Ala Ala Glu Asn Gly Phe Pro Thr Glu Lys 
65                  70                  75                  80  


Ile Leu Leu Gly Gly Asp His Leu Gly Pro Ser Pro Trp Gln Asn Glu 
                85                  90                  95      


Pro Ala Glu Gln Ala Met Ala Lys Ala Ile Glu Met Val Arg Ala Tyr 
            100                 105                 110         


Val Gln Ala Gly Tyr Thr Lys Ile His Leu Asp Cys Ser Met Pro Leu 
        115                 120                 125             


Gly Gly Glu Arg Gln Leu Pro Val Glu Val Ile Ala Gln Arg Thr Val 
    130                 135                 140                 


Gln Leu Ala Glu Ala Ala Glu Gln Ala Ala His Glu Ser Arg Leu Thr 
145                 150                 155                 160 


Ser His Thr Leu Arg Tyr Val Ile Gly Ser Glu Val Pro Pro Pro Gly 
                165                 170                 175     


Gly Ala Ile Gly Pro His Glu Gly Leu Arg Val Thr Pro Val Glu Glu 
            180                 185                 190         


Ala Arg Gln Thr Leu Glu Val Met Gln Ala Ala Phe His Gln Ala Gly 
        195                 200                 205             


Leu Glu Ala Ala Trp Glu Arg Val Arg Ala Leu Val Val Gln Pro Gly 
    210                 215                 220                 


Val Glu Phe Gly Asp Asp Phe Val His Asp Tyr Asp Pro Ala Ala Ala 
225                 230                 235                 240 


Ala Gly Leu Ala Arg Phe Ile Glu Thr Val Pro Asn Leu Val Tyr Glu 
                245                 250                 255     


Ala His Ser Thr Asp Tyr Gln Thr Pro Glu Ser Leu Ala Ala Leu Val 
            260                 265                 270         


Arg Asp His Phe Ala Ile Leu Lys Val Gly Pro Ala Leu Thr Phe Ala 
        275                 280                 285             


Leu Arg Glu Ala Val Phe Ala Leu Ala Met Ile Glu Asn Glu Leu Phe 
    290                 295                 300                 


Pro Ala Glu Glu Arg Ser His Leu Val Glu Arg Leu Glu Ala Ala Met 
305                 310                 315                 320 


Leu Arg Gln Pro Gly His Trp Gln Arg His Tyr His Gly Glu Glu Arg 
                325                 330                 335     


Gln Gln Ala Leu Ala Arg Lys Tyr Ser Phe Ser Asp Arg Ile Arg Tyr 
            340                 345                 350         


Tyr Trp Gly Asp Pro Asp Val Gln Ala Ala Phe Arg Gln Leu Leu Ala 
        355                 360                 365             


Asn Leu Glu Arg Val Ala Pro Leu Pro Leu Thr Leu Leu Ser Gln Tyr 
    370                 375                 380                 


Leu Pro Glu Met Phe Gly Glu Ile Arg Arg Gly Leu Leu Leu Asn His 
385                 390                 395                 400 


Pro Ala Ala Phe Leu Glu Arg Lys Ile Gln Ala Val Leu Asp Thr Tyr 
                405                 410                 415     


Arg Ala Ala Cys Gly Glu Glu Asp 
            420                 


<210>  8
<211>  822
<212>  PRT
<213>  Thermotoga maritima

<400>  8

Met Leu Glu Lys Leu Pro Glu Asn Leu Lys Glu Leu Glu Ser Leu Ala 
1               5                   10                  15      


Tyr Asn Leu Trp Trp Ser Trp Ser Arg Pro Ala Gln Arg Leu Trp Arg 
            20                  25                  30          


Met Ile Asp Ser Glu Lys Trp Glu Glu His Arg Asn Pro Val Lys Ile 
        35                  40                  45              


Leu Arg Glu Val Ser Lys Glu Arg Leu Glu Glu Leu Ser Lys Asp Glu 
    50                  55                  60                  


Asp Phe Ile Ala Leu Tyr Glu Leu Thr Leu Glu Arg Phe Thr Asp Tyr 
65                  70                  75                  80  


Met Glu Arg Glu Asp Thr Trp Phe Asn Val Asn Tyr Pro Glu Trp Asp 
                85                  90                  95      


Glu Lys Ile Val Tyr Met Cys Met Glu Tyr Gly Leu Thr Lys Ala Leu 
            100                 105                 110         


Pro Ile Tyr Ser Gly Gly Leu Gly Ile Leu Ala Gly Asp His Leu Lys 
        115                 120                 125             


Ser Ala Ser Asp Leu Gly Leu Pro Leu Ile Ala Val Gly Leu Leu Tyr 
    130                 135                 140                 


Lys His Gly Tyr Phe Thr Gln Gln Ile Asp Ser Asp Gly Arg Gln Ile 
145                 150                 155                 160 


Glu Ile Phe Pro Glu Tyr Asp Ile Glu Glu Leu Pro Met Lys Pro Leu 
                165                 170                 175     


Arg Asp Glu Asp Gly Asn Gln Val Ile Val Glu Val Pro Ile Asp Asn 
            180                 185                 190         


Asp Thr Val Lys Ala Arg Val Phe Glu Val Gln Val Gly Arg Val Lys 
        195                 200                 205             


Leu Tyr Leu Leu Asp Thr Asp Phe Glu Glu Asn Glu Asp Arg Phe Arg 
    210                 215                 220                 


Lys Ile Cys Asp Tyr Leu Tyr Asn Pro Glu Pro Asp Val Arg Val Ser 
225                 230                 235                 240 


Gln Glu Ile Leu Leu Gly Ile Gly Gly Met Lys Leu Leu Lys Thr Leu 
                245                 250                 255     


Lys Ile Lys Pro Gly Val Ile His Leu Asn Glu Gly His Pro Ala Phe 
            260                 265                 270         


Ser Ser Leu Glu Arg Ile Lys Ser Tyr Met Glu Glu Gly Tyr Ser Phe 
        275                 280                 285             


Thr Glu Ala Leu Glu Ile Val Arg Gln Thr Thr Val Phe Thr Thr His 
    290                 295                 300                 


Thr Pro Val Pro Ala Gly His Asp Arg Phe Pro Phe Asp Phe Val Glu 
305                 310                 315                 320 


Lys Lys Leu Thr Lys Phe Phe Glu Gly Phe Glu Ser Lys Glu Leu Leu 
                325                 330                 335     


Met Asn Leu Gly Lys Asp Glu Asp Gly Asn Phe Asn Met Thr Tyr Leu 
            340                 345                 350         


Ala Leu Arg Thr Ser Ser Phe Ile Asn Gly Val Ser Lys Leu His Ala 
        355                 360                 365             


Asp Val Ser Arg Arg Met Phe Lys Asn Val Trp Lys Gly Val Pro Val 
    370                 375                 380                 


Glu Glu Ile Pro Ile Glu Gly Ile Thr Asn Gly Val His Met Gly Thr 
385                 390                 395                 400 


Trp Ile Asn Arg Glu Met Arg Lys Leu Phe Asp Arg Tyr Leu Gly Arg 
                405                 410                 415     


Val Trp Arg Glu His Thr Asp Leu Glu Gly Ile Trp Tyr Gly Val Asp 
            420                 425                 430         


Arg Ile Pro Asp Glu Glu Leu Trp Glu Ala His Leu Asn Ala Lys Lys 
        435                 440                 445             


Arg Phe Ile Asp Tyr Ile Arg Glu Ser Ile Lys Arg Arg Asn Glu Arg 
    450                 455                 460                 


Leu Gly Ile Asn Glu Pro Leu Pro Glu Ile Ser Glu Asn Val Leu Ile 
465                 470                 475                 480 


Ile Gly Phe Ala Arg Arg Phe Ala Thr Tyr Lys Arg Ala Val Leu Leu 
                485                 490                 495     


Phe Ser Asp Leu Glu Arg Leu Lys Arg Ile Val Asn Asn Ser Glu Arg 
            500                 505                 510         


Pro Val Tyr Ile Val Tyr Ala Gly Lys Ala His Pro Arg Asp Glu Gly 
        515                 520                 525             


Gly Lys Glu Phe Leu Arg Arg Ile Tyr Glu Val Ser Gln Met Pro Asp 
    530                 535                 540                 


Phe Lys Asn Lys Ile Ile Val Leu Glu Asn Tyr Asp Ile Gly Met Ala 
545                 550                 555                 560 


Arg Leu Met Val Ser Gly Val Asp Val Trp Leu Asn Asn Pro Arg Arg 
                565                 570                 575     


Pro Met Glu Ala Ser Gly Thr Ser Gly Met Lys Ala Ala Ala Asn Gly 
            580                 585                 590         


Val Leu Asn Ala Ser Val Tyr Asp Gly Trp Trp Val Glu Gly Tyr Asn 
        595                 600                 605             


Gly Arg Asn Gly Trp Val Ile Gly Asp Glu Ser Val Leu Pro Glu Thr 
    610                 615                 620                 


Glu Ala Asp Asp Pro Lys Asp Ala Glu Ala Leu Tyr Glu Leu Leu Glu 
625                 630                 635                 640 


Asn Glu Ile Ile Pro Thr Tyr Tyr Glu Asn Arg Glu Lys Trp Ile Phe 
                645                 650                 655     


Met Met Lys Glu Ser Ile Lys Ser Val Ala Pro Lys Phe Ser Thr Thr 
            660                 665                 670         


Arg Met Leu Lys Glu Tyr Thr Glu Lys Phe Tyr Ile Lys Gly Leu Val 
        675                 680                 685             


Asn Arg Glu Trp Leu Glu Arg Arg Glu Asn Val Glu Lys Ile Gly Ala 
    690                 695                 700                 


Trp Lys Glu Arg Ile Leu Lys Asn Trp Glu Asn Val Ser Ile Glu Arg 
705                 710                 715                 720 


Ile Val Leu Glu Asp Ser Lys Ser Val Glu Val Thr Val Lys Leu Gly 
                725                 730                 735     


Asp Leu Thr Pro Asn Asp Val Ile Val Glu Leu Val Ala Gly Arg Gly 
            740                 745                 750         


Glu Gly Met Glu Asp Leu Glu Val Trp Lys Val Ile His Ile Arg Arg 
        755                 760                 765             


Tyr Arg Lys Glu Asn Asp Leu Phe Val Tyr Thr Tyr Thr Asn Gly Val 
    770                 775                 780                 


Leu Gly His Leu Gly Ser Pro Gly Trp Phe Tyr Ala Val Arg Val Ile 
785                 790                 795                 800 


Pro Tyr His Pro Arg Leu Pro Ile Lys Phe Leu Pro Glu Val Pro Val 
                805                 810                 815     


Val Trp Lys Lys Val Leu 
            820         


<210>  9
<211>  456
<212>  PRT
<213>  Thermococcus kodakaraensis

<400>  9

Met Gly Lys Leu Phe Gly Thr Phe Gly Val Arg Gly Ile Ala Asn Glu 
1               5                   10                  15      


Glu Ile Thr Pro Glu Phe Ala Leu Lys Ile Gly Met Ala Phe Gly Thr 
            20                  25                  30          


Leu Leu Lys Arg Glu Gly Arg Glu Arg Pro Leu Val Val Val Gly Arg 
        35                  40                  45              


Asp Thr Arg Val Ser Gly Glu Met Leu Lys Asp Ala Leu Ile Ser Gly 
    50                  55                  60                  


Leu Leu Ser Thr Gly Cys Asp Val Ile Asp Val Gly Ile Ala Pro Thr 
65                  70                  75                  80  


Pro Ala Ile Gln Trp Ala Thr Asn His Phe Asn Ala Asp Gly Gly Ala 
                85                  90                  95      


Val Ile Thr Ala Ser His Asn Pro Pro Glu Tyr Asn Gly Ile Lys Leu 
            100                 105                 110         


Leu Glu Pro Asn Gly Met Gly Leu Lys Lys Glu Arg Glu Ala Ile Val 
        115                 120                 125             


Glu Glu Leu Phe Phe Ser Glu Asp Phe His Arg Ala Lys Trp Asn Glu 
    130                 135                 140                 


Ile Gly Glu Leu Arg Lys Glu Asp Ile Ile Lys Pro Tyr Ile Glu Ala 
145                 150                 155                 160 


Ile Lys Asn Arg Val Asp Val Glu Ala Ile Lys Lys Arg Arg Pro Phe 
                165                 170                 175     


Val Val Val Asp Thr Ser Asn Gly Ala Gly Ser Leu Thr Leu Pro Tyr 
            180                 185                 190         


Leu Leu Arg Glu Leu Gly Cys Lys Val Val Ser Val Asn Ala His Pro 
        195                 200                 205             


Asp Gly His Phe Pro Ala Arg Asn Pro Glu Pro Asn Glu Glu Asn Leu 
    210                 215                 220                 


Lys Gly Phe Met Glu Ile Val Lys Ala Leu Gly Ala Asp Phe Gly Val 
225                 230                 235                 240 


Ala Gln Asp Gly Asp Ala Asp Arg Ala Val Phe Ile Asp Glu Asn Gly 
                245                 250                 255     


Arg Phe Ile Gln Gly Asp Lys Thr Phe Ala Leu Val Ala Asp Ala Val 
            260                 265                 270         


Leu Arg Glu Asn Gly Gly Gly Leu Leu Val Thr Thr Ile Ala Thr Ser 
        275                 280                 285             


Asn Leu Leu Asp Asp Ile Ala Lys Arg Asn Gly Ala Lys Val Met Arg 
    290                 295                 300                 


Thr Lys Val Gly Asp Leu Ile Val Ala Arg Ala Leu Leu Glu Asn Asn 
305                 310                 315                 320 


Gly Thr Ile Gly Gly Glu Glu Asn Gly Gly Val Ile Phe Pro Asp Phe 
                325                 330                 335     


Val Leu Gly Arg Asp Gly Ala Met Thr Thr Ala Lys Ile Val Glu Ile 
            340                 345                 350         


Phe Ala Lys Ser Gly Lys Lys Phe Ser Glu Leu Ile Asp Glu Leu Pro 
        355                 360                 365             


Lys Tyr Tyr Gln Phe Lys Thr Lys Arg His Val Glu Gly Asp Arg Lys 
    370                 375                 380                 


Ala Ile Val Ala Lys Val Ala Glu Leu Ala Glu Lys Lys Gly Tyr Lys 
385                 390                 395                 400 


Ile Asp Thr Thr Asp Gly Thr Lys Ile Ile Phe Asp Asp Gly Trp Val 
                405                 410                 415     


Leu Val Arg Ala Ser Gly Thr Glu Pro Ile Ile Arg Ile Phe Ser Glu 
            420                 425                 430         


Ala Lys Ser Glu Glu Lys Ala Arg Glu Tyr Leu Glu Leu Gly Ile Lys 
        435                 440                 445             


Leu Leu Glu Glu Ala Leu Lys Gly 
    450                 455     


<210>  10
<211>  408
<212>  PRT
<213>  Dictyoglomus thermophilum

<400>  10

Met Trp Leu Ser Lys Asp Tyr Leu Arg Lys Lys Gly Val Tyr Ser Ile 
1               5                   10                  15      


Cys Ser Ser Asn Pro Tyr Val Ile Glu Ala Ser Val Glu Phe Ala Lys 
            20                  25                  30          


Glu Lys Asn Asp Tyr Ile Leu Ile Glu Ala Thr Pro His Gln Ile Asn 
        35                  40                  45              


Gln Phe Gly Gly Tyr Ser Gly Met Thr Pro Glu Asp Phe Lys Asn Phe 
    50                  55                  60                  


Val Met Gly Ile Ile Lys Glu Lys Gly Ile Glu Glu Asp Arg Val Ile 
65                  70                  75                  80  


Leu Gly Gly Asp His Leu Gly Pro Leu Pro Trp Gln Asp Glu Pro Ser 
                85                  90                  95      


Ser Ser Ala Met Lys Lys Ala Lys Asp Leu Ile Arg Ala Phe Val Glu 
            100                 105                 110         


Ser Gly Tyr Lys Lys Ile His Leu Asp Cys Ser Met Ser Leu Ser Asp 
        115                 120                 125             


Asp Pro Val Val Leu Ser Pro Glu Lys Ile Ala Glu Arg Glu Arg Glu 
    130                 135                 140                 


Leu Leu Glu Val Ala Glu Glu Thr Ala Arg Lys Tyr Asn Phe Gln Pro 
145                 150                 155                 160 


Val Tyr Val Val Gly Thr Asp Val Pro Val Ala Gly Gly Gly Glu Glu 
                165                 170                 175     


Glu Gly Ile Thr Ser Val Glu Asp Phe Arg Val Ala Ile Ser Ser Leu 
            180                 185                 190         


Lys Lys Tyr Phe Glu Asp Val Pro Arg Ile Trp Asp Arg Ile Ile Gly 
        195                 200                 205             


Phe Val Ile Met Leu Gly Ile Gly Phe Asn Tyr Glu Lys Val Phe Glu 
    210                 215                 220                 


Tyr Asp Arg Ile Lys Val Arg Lys Ile Leu Glu Glu Val Lys Lys Glu 
225                 230                 235                 240 


Asn Leu Phe Val Glu Gly His Ser Thr Asp Tyr Gln Thr Lys Arg Ala 
                245                 250                 255     


Leu Arg Asp Met Val Glu Asp Gly Val Arg Ile Leu Lys Val Gly Pro 
            260                 265                 270         


Ala Leu Thr Ala Ser Phe Arg Arg Gly Val Phe Leu Leu Ser Ser Ile 
        275                 280                 285             


Glu Asp Glu Leu Ile Ser Glu Asp Lys Arg Ser Asn Ile Lys Lys Val 
    290                 295                 300                 


Val Leu Glu Thr Met Leu Lys Asp Asp Lys Tyr Trp Arg Lys Tyr Tyr 
305                 310                 315                 320 


Lys Asp Ser Glu Arg Leu Glu Leu Asp Ile Trp Tyr Asn Leu Leu Asp 
                325                 330                 335     


Arg Ile Arg Tyr Tyr Trp Glu Tyr Lys Glu Ile Lys Ile Ala Leu Asn 
            340                 345                 350         


Arg Leu Phe Glu Asn Phe Ser Glu Gly Val Asp Ile Arg Tyr Ile Tyr 
        355                 360                 365             


Gln Tyr Phe Tyr Asp Ser Tyr Phe Lys Val Arg Glu Gly Lys Ile Arg 
    370                 375                 380                 


Asn Asp Pro Arg Glu Leu Ile Lys Asn Glu Ile Lys Lys Val Leu Glu 
385                 390                 395                 400 


Asp Tyr His Tyr Ala Val Asn Leu 
                405             


<210>  11
<211>  223
<212>  PRT
<213>  Archaeoglobus fugidis

<400>  11

Met Phe Lys Pro Lys Ala Ile Ala Val Asp Ile Asp Gly Thr Leu Thr 
1               5                   10                  15      


Asp Arg Lys Arg Ala Leu Asn Cys Arg Ala Val Glu Ala Leu Arg Lys 
            20                  25                  30          


Val Lys Ile Pro Val Ile Leu Ala Thr Gly Asn Ile Ser Cys Phe Ala 
        35                  40                  45              


Arg Ala Ala Ala Lys Leu Ile Gly Val Ser Asp Val Val Ile Cys Glu 
    50                  55                  60                  


Asn Gly Gly Val Val Arg Phe Glu Tyr Asp Gly Glu Asp Ile Val Leu 
65                  70                  75                  80  


Gly Asp Lys Glu Lys Cys Val Glu Ala Val Arg Val Leu Glu Lys His 
                85                  90                  95      


Tyr Glu Val Glu Leu Leu Asp Phe Glu Tyr Arg Lys Ser Glu Val Cys 
            100                 105                 110         


Met Arg Arg Ser Phe Asp Ile Asn Glu Ala Arg Lys Leu Ile Glu Gly 
        115                 120                 125             


Met Gly Val Lys Leu Val Asp Ser Gly Phe Ala Tyr His Ile Met Asp 
    130                 135                 140                 


Ala Asp Val Ser Lys Gly Lys Ala Leu Lys Phe Val Ala Glu Arg Leu 
145                 150                 155                 160 


Gly Ile Ser Ser Ala Glu Phe Ala Val Ile Gly Asp Ser Glu Asn Asp 
                165                 170                 175     


Ile Asp Met Phe Arg Val Ala Gly Phe Gly Ile Ala Val Ala Asn Ala 
            180                 185                 190         


Asp Glu Arg Leu Lys Glu Tyr Ala Asp Leu Val Thr Pro Ser Pro Asp 
        195                 200                 205             


Gly Glu Gly Val Val Glu Ala Leu Gln Phe Leu Gly Leu Leu Arg 
    210                 215                 220             


<210>  12
<211>  659
<212>  PRT
<213>  Thermococcus litoralis

<400>  12

Met Glu Arg Ile Asn Phe Ile Phe Gly Ile His Asn His Gln Pro Leu 
1               5                   10                  15      


Gly Asn Phe Gly Trp Val Phe Glu Glu Ala Tyr Asn Arg Ser Tyr Arg 
            20                  25                  30          


Pro Phe Met Glu Ile Leu Glu Glu Phe Pro Glu Met Lys Val Asn Val 
        35                  40                  45              


His Phe Ser Gly Pro Leu Leu Glu Trp Ile Glu Glu Asn Lys Pro Asp 
    50                  55                  60                  


Tyr Leu Asp Leu Leu Arg Ser Leu Ile Lys Arg Gly Gln Leu Glu Ile 
65                  70                  75                  80  


Val Val Ala Gly Phe Tyr Glu Pro Val Leu Ala Ala Ile Pro Lys Glu 
                85                  90                  95      


Asp Arg Leu Val Gln Ile Glu Met Leu Lys Asp Tyr Ala Arg Lys Leu 
            100                 105                 110         


Gly Tyr Asp Ala Lys Gly Val Trp Leu Thr Glu Arg Val Trp Gln Pro 
        115                 120                 125             


Glu Leu Val Lys Ser Leu Arg Glu Ala Gly Ile Glu Tyr Val Val Val 
    130                 135                 140                 


Asp Asp Tyr His Phe Met Ser Ala Gly Leu Ser Lys Glu Glu Leu Phe 
145                 150                 155                 160 


Trp Pro Tyr Tyr Thr Glu Asp Gly Gly Glu Val Ile Thr Val Phe Pro 
                165                 170                 175     


Ile Asp Glu Lys Leu Arg Tyr Leu Ile Pro Phe Arg Pro Val Lys Lys 
            180                 185                 190         


Thr Ile Glu Tyr Leu Glu Ser Leu Thr Ser Asp Asp Pro Ser Lys Val 
        195                 200                 205             


Ala Val Phe His Asp Asp Gly Glu Lys Phe Gly Val Trp Pro Gly Thr 
    210                 215                 220                 


Tyr Glu Trp Val Tyr Glu Lys Gly Trp Leu Arg Glu Phe Phe Asp Ala 
225                 230                 235                 240 


Ile Thr Ser Asn Glu Lys Ile Asn Leu Met Thr Tyr Ser Glu Tyr Leu 
                245                 250                 255     


Ser Lys Phe Thr Pro Arg Gly Leu Val Tyr Leu Pro Ile Ala Ser Tyr 
            260                 265                 270         


Phe Glu Met Ser Glu Trp Ser Leu Pro Ala Lys Gln Ala Lys Leu Phe 
        275                 280                 285             


Val Glu Phe Val Glu Gln Leu Lys Glu Glu Gly Lys Phe Glu Lys Tyr 
    290                 295                 300                 


Arg Val Phe Val Arg Gly Gly Ile Trp Lys Asn Phe Phe Phe Lys Tyr 
305                 310                 315                 320 


Pro Glu Ser Asn Phe Met His Lys Arg Met Leu Met Val Ser Lys Ala 
                325                 330                 335     


Val Arg Asp Asn Pro Glu Ala Arg Lys Tyr Ile Leu Lys Ala Gln Cys 
            340                 345                 350         


Asn Asp Ala Tyr Trp His Gly Val Phe Gly Gly Ile Tyr Leu Pro His 
        355                 360                 365             


Leu Arg Arg Thr Val Trp Glu Asn Ile Ile Lys Ala Gln Arg Tyr Leu 
    370                 375                 380                 


Lys Pro Glu Asn Lys Ile Leu Asp Val Asp Phe Asp Gly Arg Ala Glu 
385                 390                 395                 400 


Ile Met Val Glu Asn Asp Gly Phe Ile Ala Thr Ile Lys Pro His Tyr 
                405                 410                 415     


Gly Gly Ser Ile Phe Glu Leu Ser Ser Lys Arg Lys Ala Val Asn Tyr 
            420                 425                 430         


Asn Asp Val Leu Pro Arg Arg Trp Glu His Tyr His Glu Val Pro Glu 
        435                 440                 445             


Ala Thr Lys Pro Glu Lys Glu Ser Glu Glu Gly Ile Ala Ser Ile His 
    450                 455                 460                 


Glu Leu Gly Lys Gln Ile Pro Glu Glu Ile Arg Arg Glu Leu Ala Tyr 
465                 470                 475                 480 


Asp Trp Gln Leu Arg Ala Ile Leu Gln Asp His Phe Ile Lys Pro Glu 
                485                 490                 495     


Glu Thr Leu Asp Asn Tyr Arg Leu Val Lys Tyr His Glu Leu Gly Asp 
            500                 505                 510         


Phe Val Asn Gln Pro Tyr Glu Tyr Glu Met Ile Glu Asn Gly Val Lys 
        515                 520                 525             


Leu Trp Arg Glu Gly Gly Val Tyr Ala Glu Glu Lys Ile Pro Ala Arg 
    530                 535                 540                 


Val Glu Lys Lys Ile Glu Leu Thr Glu Asp Gly Phe Ile Ala Lys Tyr 
545                 550                 555                 560 


Arg Val Leu Leu Glu Lys Pro Tyr Lys Ala Leu Phe Gly Val Glu Ile 
                565                 570                 575     


Asn Leu Ala Val His Ser Val Met Glu Lys Pro Glu Glu Phe Glu Ala 
            580                 585                 590         


Lys Glu Phe Glu Val Asn Asp Pro Tyr Gly Ile Gly Lys Val Arg Ile 
        595                 600                 605             


Glu Leu Asp Lys Ala Ala Lys Val Trp Lys Phe Pro Ile Lys Thr Leu 
    610                 615                 620                 


Ser Gln Ser Glu Ala Gly Trp Asp Phe Ile Gln Gln Gly Val Ser Tyr 
625                 630                 635                 640 


Thr Met Leu Phe Pro Ile Glu Lys Glu Leu Glu Phe Thr Val Arg Phe 
                645                 650                 655     


Arg Glu Leu 
            


