                         SEQUENCE LISTING

<110>  Microcures, Inc.
 
<120>  FIDGETIN-LIKE 2 siRNA-ENHANCED POLOXAMER-BASED HYDROGEL FOR WOUND
        HEALING

<130>  P-586862-PC

<150>  62/749325
<151>  2018-10-23

<160>  12    

<170>  PatentIn version 3.5

<210>  1
<211>  4711
<212>  DNA
<213>  Homo sapiens

<400>  1
agtgagctat ggggacacta ctgcactgta gcctgggcaa cagagcaaga ccttgtctca       60

aaaatgtata tatattttgg gctttttttc ctaaaacggg aactacaaca gcatatttgc      120

gagctgatga gagtgaccca gcagagaggg aaatggatca gctctgttga agatgcactg      180

gacaccagaa cacgcccagc ccctcaacca gtggccagag cagcacctgg acgtctcctc      240

caccaccccg tcgccggccc acaagttgga gttgccccct gggggtcgcc aacgctgcca      300

ctacgcttgg gcacacgacg acatctcagc cctcactgcc tccaacctcc taaagcgcta      360

tgcagagaag tactctgggg tcttggattc tccctacgag cgtccggccc tgggcgggta      420

cagcgacgcc tccttcctca acggcgccaa aggggatccc gagccctggc cagggccgga      480

gccaccctac cccttggcct cactccacga aggcctccca ggaaccaaat cgggcggtgg      540

cggcggttcc ggggccctgg ggggctcccc agttttagcc gggaacctcc ctgaacccct      600

ctacgccggc aatgcgtgcg ggggcccatc ggcggcgccc gagtacgcgg ccggctacgg      660

cggggggtac ctggcgccgg gttactgcgc gcagacgggc gccgcgctgc ccccgccgcc      720

cccggccgcg ctcctgcagc ccccaccgcc tccggggtac gggccctcag cgccgctgta      780

caactatccc gcagggggct acgcagcgca gcccggctat ggcgcgctcc cgccgccccc      840

aggcccaccc ccggccccct acctgacccc gggcctgccc gcgcccacgc ccctgcccgc      900

gccggcaccg cccaccgcct atggcttccc cacggccgcg ccgggtgccg aatccgggct      960

gtcgctgaag cgcaaggccg ccgacgaggg gcccgagggc cgctaccgca agtacgcgta     1020

cgagcccgcc aaggcccccg tggctgacgg agcctcctac cccgccgcgg acaacggcga     1080

atgtcggggc aacgggttcc gggccaagcc gccaggagcc gcggaggagg cgtcgggcaa     1140

gtacggtggc ggcgtccccc tcaaggtcct gggctccccc gtctacggcc cgcaactgga     1200

gccctttgaa aagttcccgg agcgggcccc ggctcctcgt ggggggttcg ccgtgccgtc     1260

gggggagact cccaaaggcg tggaccctgg ggccctggag ctggtgacga gcaagatggt     1320

ggactgcggg cccccggtgc agtgggcgga tgtggcgggc cagggcgcgc tcaaggcggc     1380

gctggaggag gagctggtgt ggcccctgct caggccgccc gcctacccgg gcagcctgcg     1440

cccgccgcgg accgtcctgc tctttgggcc gcggggcgcg ggcaaagcgc tgctgggccg     1500

ctgcctcgcc acgcagctgg gcgccacgct gttgcgcctg cgcggcgcga ccctggctgc     1560

gcccggcgcc gccgagggcg cgcgcctcct ccaggccgcc ttcgcggccg cgcgctgccg     1620

cccaccctcc gtactcctca tcagcgagct agaggcgctg ctccccgccc gggacgacgg     1680

cgcggcggca gggggcgcgc tgcaggtgcc gctcctggcc tgcctggacg ggggctgcgg     1740

cgcgggggct gacggcgtgc tggttgtggg caccacctcg cggcccgcgg ctctggacga     1800

ggcgacccgc cggcgcttct ctctccgctt ctacgtggcg ctgcccgaca gcccggcccg     1860

cgggcagatc ctgcagcggg cgctggccca gcagggctgc gcgctcagtg agcgggaact     1920

ggcggcgctg gtgcagggca cgcagggctt ctctgggggc gagctggggc agctgtgcca     1980

gcaggcggcg gccggggcgg gcctcccggg gctgcagcgc cccctctcct acaaggacct     2040

ggaggcggcg ctggccaagg tgggccctag ggcctctgcc aaggaactgg actcgttcgt     2100

ggagtgggac aaaatgtacg gctccggaca ctgacggcgc gcgggggagg ccgcgggagc     2160

cgcagtccct ccgtccccgc cgcctccgcg tgggagggat gtcactgact aaacccggct     2220

ggcaggggct ggagtggtga atgtgggatc ggggacagga ggggtctgcc ggtggatatt     2280

ttttttttcg tgggaaggaa aatgcttctg ccaggcagat gccatatgcg ccgtgtactc     2340

aggtttttcc tatttattgt ggactggaag ctcgccatct ccgcccggca gaccgggcag     2400

atccggcatg ggctggcacc cggggcctta agaactcctg ctctcttgcc acaacgcttt     2460

tgtctcctcg ctatctgaat ggcaccctcc ttctccctca ctctctccat cccattctct     2520

gcattctctt ggttttctct cccttttgct ttgtcgctga cacccctgcc caccccatgc     2580

tggccctgtt tctctcctgc ccctccctcc ccagctctcc atccctcacc ctctgtgctt     2640

ctgtctccat ccctggctct ccagcgtccc tggccttttg gtccctgagc tttaatgcct     2700

ttccctgcct tctgttctta tttggactgc agtggccctt tgcaggagct ctggaggccc     2760

aggggctgag gaggagggtt acccctctac ccatctgaaa cctagggtct agggggatca     2820

aggaaaaaaa gtccccaaag aaggggaatt ttttgtttgt ttttgagggg agatcccaga     2880

aatgtagctt gtttcatatt ttagtcttct tatttttgta aaatgtgtag aatttgctgt     2940

ttttcttttt cttttgacaa ctcaggaaga aactgacctc agaaagaatg ttagactttg     3000

gctgctctcc tgtgtgcccc tcacacctgc cccctccccc ccactccatc caggggacca     3060

aattctccca gacactcaaa aaatgagact tacggggaag gggagaggaa gacccagagg     3120

cctcagtgaa accccagcta ttcctggtca gaagcagaat gtattcctaa gggcttcctc     3180

cccagggccg aggcctaggc atgaatgtgg ggagtgggct gtggggtttg agagaaggga     3240

ggccttattc ctctcctgct gctccccacc ccctgcccca cccaacccct ccgctgagtg     3300

ttttctgtga agggctatcc agagttagga tgcccttgcc caattccttc ctgagaccca     3360

gaaggtaggg tgggagggcc caaatgggaa ggtgacctaa gcagaaagtc tccagaaagg     3420

tcatgtcccc tggccctgcc ttggcagagg tccccagtga cttatgctag gaggattcca     3480

tctgggtaga cagtctggcc acaaaatcag ctactggacc tcagccatct ctgctggagg     3540

ctctgaggag gagtgagcat ccctcacttg tgggggctct gtgaggaaat gtgccttccc     3600

cattcccccg gagtcctagg tctggagctc cagggctggg agagggtgag ggagatgggc     3660

aggggtgttt tctctgacct tgggggctta gtctcagtcc tgcctgaact ttccactagg     3720

cttggaaccc ttccaagaac catatttctc tccttcccac caattttccc ttgatgaggc     3780

tttagcagtt tgctcccacc acccccagcc catttcacaa ctctgatctt agtccaaagc     3840

aggggacacg cccccccacc accacttttt ctctctccca tctcagcctc ctgtgcagtt     3900

ccttgcctgc ccgtgcattt cctagagtct actgcctccc ccctggctgg gagggtgtct     3960

gggggggatc tttcaggggc cctggcaccc agggcctgtg ctggcctagg agtgctgacc     4020

agaaggctgc tctgttcccc cccacccccg ttgctttctg gccccctctt tggagccagc     4080

cacccacagg gctttggtgc ctcagaagca gtgggctgcc gggtcacagc cgcaggctgc     4140

aaaagaccct cggagggagc atggagtgag gggttctctc tcaggtgtgt atgtattggg     4200

gggtgggggt gggtggaggg tgtcagggaa gttggggtgg gatcccagcc ttcccttcaa     4260

gaggcaggga gctctgggag gtggagtccc caccgctttc tctactaggc tcctcctgtt     4320

ccccaggctt ggggagcttt gcacaaggag actgccccca gcctagtggc acctacctca     4380

tgggctctgg ggcaggtagg ggaagggcca gtccagctct ggtaatgctg gggggaggca     4440

taccaaagaa tccaggggca gggagtgggg agggtgactt ccgagctggc ctctcccctt     4500

cctctaccca gactggggct gggatcctct cctcccgctg taaccatttc tacctcattt     4560

tgctgcgtgt tgtacatgga cgtatttatc tcctgtctga cgatgctctg cagttgtggt     4620

ctgtctacct cagaagagac tgtattttaa aagaaagtat tacacagtat taaagcgatg     4680

acatgtggtt tgcaaaaaaa aaaaaaaaaa a                                    4711


<210>  2
<211>  653
<212>  PRT
<213>  Homo sapiens

<400>  2

Met His Trp Thr Pro Glu His Ala Gln Pro Leu Asn Gln Trp Pro Glu 
1               5                   10                  15      


Gln His Leu Asp Val Ser Ser Thr Thr Pro Ser Pro Ala His Lys Leu 
            20                  25                  30          


Glu Leu Pro Pro Gly Gly Arg Gln Arg Cys His Tyr Ala Trp Ala His 
        35                  40                  45              


Asp Asp Ile Ser Ala Leu Thr Ala Ser Asn Leu Leu Lys Arg Tyr Ala 
    50                  55                  60                  


Glu Lys Tyr Ser Gly Val Leu Asp Ser Pro Tyr Glu Arg Pro Ala Leu 
65                  70                  75                  80  


Gly Gly Tyr Ser Asp Ala Ser Phe Leu Asn Gly Ala Lys Gly Asp Pro 
                85                  90                  95      


Glu Pro Trp Pro Gly Pro Glu Pro Pro Tyr Pro Leu Ala Ser Leu His 
            100                 105                 110         


Glu Gly Leu Pro Gly Thr Lys Ser Gly Gly Gly Gly Gly Ser Gly Ala 
        115                 120                 125             


Leu Gly Gly Ser Pro Val Leu Ala Gly Asn Leu Pro Glu Pro Leu Tyr 
    130                 135                 140                 


Ala Gly Asn Ala Cys Gly Gly Pro Ser Ala Ala Pro Glu Tyr Ala Ala 
145                 150                 155                 160 


Gly Tyr Gly Gly Gly Tyr Leu Ala Pro Gly Tyr Cys Ala Gln Thr Gly 
                165                 170                 175     


Ala Ala Leu Pro Pro Pro Pro Pro Ala Ala Leu Leu Gln Pro Pro Pro 
            180                 185                 190         


Pro Pro Gly Tyr Gly Pro Ser Ala Pro Leu Tyr Asn Tyr Pro Ala Gly 
        195                 200                 205             


Gly Tyr Ala Ala Gln Pro Gly Tyr Gly Ala Leu Pro Pro Pro Pro Gly 
    210                 215                 220                 


Pro Pro Pro Ala Pro Tyr Leu Thr Pro Gly Leu Pro Ala Pro Thr Pro 
225                 230                 235                 240 


Leu Pro Ala Pro Ala Pro Pro Thr Ala Tyr Gly Phe Pro Thr Ala Ala 
                245                 250                 255     


Pro Gly Ala Glu Ser Gly Leu Ser Leu Lys Arg Lys Ala Ala Asp Glu 
            260                 265                 270         


Gly Pro Glu Gly Arg Tyr Arg Lys Tyr Ala Tyr Glu Pro Ala Lys Ala 
        275                 280                 285             


Pro Val Ala Asp Gly Ala Ser Tyr Pro Ala Ala Asp Asn Gly Glu Cys 
    290                 295                 300                 


Arg Gly Asn Gly Phe Arg Ala Lys Pro Pro Gly Ala Ala Glu Glu Ala 
305                 310                 315                 320 


Ser Gly Lys Tyr Gly Gly Gly Val Pro Leu Lys Val Leu Gly Ser Pro 
                325                 330                 335     


Val Tyr Gly Pro Gln Leu Glu Pro Phe Glu Lys Phe Pro Glu Arg Ala 
            340                 345                 350         


Pro Ala Pro Arg Gly Gly Phe Ala Val Pro Ser Gly Glu Thr Pro Lys 
        355                 360                 365             


Gly Val Asp Pro Gly Ala Leu Glu Leu Val Thr Ser Lys Met Val Asp 
    370                 375                 380                 


Cys Gly Pro Pro Val Gln Trp Ala Asp Val Ala Gly Gln Gly Ala Leu 
385                 390                 395                 400 


Lys Ala Ala Leu Glu Glu Glu Leu Val Trp Pro Leu Leu Arg Pro Pro 
                405                 410                 415     


Ala Tyr Pro Gly Ser Leu Arg Pro Pro Arg Thr Val Leu Leu Phe Gly 
            420                 425                 430         


Pro Arg Gly Ala Gly Lys Ala Leu Leu Gly Arg Cys Leu Ala Thr Gln 
        435                 440                 445             


Leu Gly Ala Thr Leu Leu Arg Leu Arg Gly Ala Thr Leu Ala Ala Pro 
    450                 455                 460                 


Gly Ala Ala Glu Gly Ala Arg Leu Leu Gln Ala Ala Phe Ala Ala Ala 
465                 470                 475                 480 


Arg Cys Arg Pro Pro Ser Val Leu Leu Ile Ser Glu Leu Glu Ala Leu 
                485                 490                 495     


Leu Pro Ala Arg Asp Asp Gly Ala Ala Ala Gly Gly Ala Leu Gln Val 
            500                 505                 510         


Pro Leu Leu Ala Cys Leu Asp Gly Gly Cys Gly Ala Gly Ala Asp Gly 
        515                 520                 525             


Val Leu Val Val Gly Thr Thr Ser Arg Pro Ala Ala Leu Asp Glu Ala 
    530                 535                 540                 


Thr Arg Arg Arg Phe Ser Leu Arg Phe Tyr Val Ala Leu Pro Asp Ser 
545                 550                 555                 560 


Pro Ala Arg Gly Gln Ile Leu Gln Arg Ala Leu Ala Gln Gln Gly Cys 
                565                 570                 575     


Ala Leu Ser Glu Arg Glu Leu Ala Ala Leu Val Gln Gly Thr Gln Gly 
            580                 585                 590         


Phe Ser Gly Gly Glu Leu Gly Gln Leu Cys Gln Gln Ala Ala Ala Gly 
        595                 600                 605             


Ala Gly Leu Pro Gly Leu Gln Arg Pro Leu Ser Tyr Lys Asp Leu Glu 
    610                 615                 620                 


Ala Ala Leu Ala Lys Val Gly Pro Arg Ala Ser Ala Lys Glu Leu Asp 
625                 630                 635                 640 


Ser Phe Val Glu Trp Asp Lys Met Tyr Gly Ser Gly His 
                645                 650             


<210>  3
<211>  21
<212>  RNA
<213>  Artificial

<220>
<223>  Synthetic siRNA

<400>  3
uuacacagua uuaaagcgau u                                                 21


<210>  4
<211>  21
<212>  RNA
<213>  Artificial

<220>
<223>  Synthetic siRNA

<400>  4
ucgcuuuaau acuguguaau u                                                 21


<210>  5
<211>  21
<212>  RNA
<213>  Artificial

<220>
<223>  Synthetic siRNA

<400>  5
caucugaaac cuagggucuu u                                                 21


<210>  6
<211>  21
<212>  RNA
<213>  Artificial

<220>
<223>  Synthetic

<400>  6
agacccuagg uuucagaugu u                                                 21


<210>  7
<211>  21
<212>  RNA
<213>  Artificial

<220>
<223>  Synthetic

<400>  7
gugacuuaug cuaggaggau u                                                 21


<210>  8
<211>  21
<212>  RNA
<213>  Artificial

<220>
<223>  Synthetic

<400>  8
uccuccuagc auaagucacu u                                                 21


<210>  9
<211>  21
<212>  RNA
<213>  Artificial

<220>
<223>  Synthetic

<400>  9
ggucagaagc agaauguauu u                                                 21


<210>  10
<211>  21
<212>  DNA
<213>  Artificial

<220>
<223>  Synthetic

<400>  10
auacauucug cuucugaccu u                                                 21


<210>  11
<211>  23
<212>  DNA
<213>  Artificial

<220>
<223>  Synthetic

<400>  11
cagcucgagc ccuuugacad tdt                                               23


<210>  12
<211>  23
<212>  DNA
<213>  Artificial

<220>
<223>  Synthetic

<400>  12
ugucaaaggg cucgagcugd tdt                                               23


