                         SEQUENCE LISTING

<110>  Peter MacCallum Cancer Institute
 
<120>  BISPECIFIC POLYPEPTIDES FOR ENGAGEMENT OF CAR EXPRESSING IMMUNE 
       CELLS WITH ANTIGEN PRESENTING CELLS AND USES THEREOF

<130>  35533519/MKR/SJD

<150>  2018904117
<151>  2018-10-30

<150>  2019903255
<151>  2019-09-04

<160>  26    

<170>  PatentIn version 3.5

<210>  1
<211>  747
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Anti-CD40 scFv


<220>
<221>  CDS
<222>  (1)..(747)

<400>  1
atg gag gtg cag gtg gtg gag tct gat gga ggc tta gtg cag cct gga         48
Met Glu Val Gln Val Val Glu Ser Asp Gly Gly Leu Val Gln Pro Gly           
1               5                   10                  15                

agg tcc cta aaa ctc ccc tgt gca gcc tca gga ttc act ttc agt gac         96
Arg Ser Leu Lys Leu Pro Cys Ala Ala Ser Gly Phe Thr Phe Ser Asp           
            20                  25                  30                    

tat tac atg gcc tgg gtc cgc cag gct cca acg aag ggg ctg gag tgg        144
Tyr Tyr Met Ala Trp Val Arg Gln Ala Pro Thr Lys Gly Leu Glu Trp           
        35                  40                  45                        

gtc gca agc att agt tat gat ggt agt agc act tac tat cga gac tcc        192
Val Ala Ser Ile Ser Tyr Asp Gly Ser Ser Thr Tyr Tyr Arg Asp Ser           
    50                  55                  60                            

gtg aag ggc cga ttc act atc tcc aga gat aat gca aaa agc acc cta        240
Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Ser Thr Leu           
65                  70                  75                  80            

tac ctg caa atg gac agt ctg agg tct gag gac acg gcc act tat tac        288
Tyr Leu Gln Met Asp Ser Leu Arg Ser Glu Asp Thr Ala Thr Tyr Tyr           
                85                  90                  95                

tgc gga aga cac agt agc tac ttt gat tac tgg ggc caa gga gtc atg        336
Cys Gly Arg His Ser Ser Tyr Phe Asp Tyr Trp Gly Gln Gly Val Met           
            100                 105                 110                   

gtc aca gtc tcc tca ggt gga ggc ggt tca ggc gga ggt ggc tct ggc        384
Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly           
        115                 120                 125                       

ggt ggc gga tcg gac act gta ctg acc cag tct cct gct ttg gct gtg        432
Gly Gly Gly Ser Asp Thr Val Leu Thr Gln Ser Pro Ala Leu Ala Val           
    130                 135                 140                           

tct cca gga gag agg gtt acc atc tcc tgt agg gcc agt gac agt gtc        480
Ser Pro Gly Glu Arg Val Thr Ile Ser Cys Arg Ala Ser Asp Ser Val           
145                 150                 155                 160           

agt aca ctt atg cac tgg tac caa cag aaa cca gga cag caa ccc aaa        528
Ser Thr Leu Met His Trp Tyr Gln Gln Lys Pro Gly Gln Gln Pro Lys           
                165                 170                 175               

ctc ctc atc tat cta gca tca cac cta gaa tct ggg gtc cct gcc agg        576
Leu Leu Ile Tyr Leu Ala Ser His Leu Glu Ser Gly Val Pro Ala Arg           
            180                 185                 190                   

ttc agt ggc agt ggg tct ggg aca gac ttc acc ctc acc att gat cct        624
Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Asp Pro           
        195                 200                 205                       

gtg gag gct gat gac act gca acc tat tac tgt cag cag agt tgg aat        672
Val Glu Ala Asp Asp Thr Ala Thr Tyr Tyr Cys Gln Gln Ser Trp Asn           
    210                 215                 220                           

gat ccg tgg acg ttc ggt gga ggc acc aag ctg gaa ttg aaa aat ggg        720
Asp Pro Trp Thr Phe Gly Gly Gly Thr Lys Leu Glu Leu Lys Asn Gly           
225                 230                 235                 240           

gcc gtc gag cac cac cac cac cac cac                                    747
Ala Val Glu His His His His His His                                       
                245                                                       


<210>  2
<211>  249
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2

Met Glu Val Gln Val Val Glu Ser Asp Gly Gly Leu Val Gln Pro Gly 
1               5                   10                  15      


Arg Ser Leu Lys Leu Pro Cys Ala Ala Ser Gly Phe Thr Phe Ser Asp 
            20                  25                  30          


Tyr Tyr Met Ala Trp Val Arg Gln Ala Pro Thr Lys Gly Leu Glu Trp 
        35                  40                  45              


Val Ala Ser Ile Ser Tyr Asp Gly Ser Ser Thr Tyr Tyr Arg Asp Ser 
    50                  55                  60                  


Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Ser Thr Leu 
65                  70                  75                  80  


Tyr Leu Gln Met Asp Ser Leu Arg Ser Glu Asp Thr Ala Thr Tyr Tyr 
                85                  90                  95      


Cys Gly Arg His Ser Ser Tyr Phe Asp Tyr Trp Gly Gln Gly Val Met 
            100                 105                 110         


Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
        115                 120                 125             


Gly Gly Gly Ser Asp Thr Val Leu Thr Gln Ser Pro Ala Leu Ala Val 
    130                 135                 140                 


Ser Pro Gly Glu Arg Val Thr Ile Ser Cys Arg Ala Ser Asp Ser Val 
145                 150                 155                 160 


Ser Thr Leu Met His Trp Tyr Gln Gln Lys Pro Gly Gln Gln Pro Lys 
                165                 170                 175     


Leu Leu Ile Tyr Leu Ala Ser His Leu Glu Ser Gly Val Pro Ala Arg 
            180                 185                 190         


Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Asp Pro 
        195                 200                 205             


Val Glu Ala Asp Asp Thr Ala Thr Tyr Tyr Cys Gln Gln Ser Trp Asn 
    210                 215                 220                 


Asp Pro Trp Thr Phe Gly Gly Gly Thr Lys Leu Glu Leu Lys Asn Gly 
225                 230                 235                 240 


Ala Val Glu His His His His His His 
                245                 


<210>  3
<211>  621
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Anti-MHCII scFv


<220>
<221>  CDS
<222>  (1)..(621)

<400>  3
gag gtg cag ctt cag gag tca gga cct ggc ctt gtg aaa ccc tca cag         48
Glu Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Gln           
1               5                   10                  15                

tca ctc tcc ctc acc tgt tct gtc act gct tac ttc atc act agt aat         96
Ser Leu Ser Leu Thr Cys Ser Val Thr Ala Tyr Phe Ile Thr Ser Asn           
            20                  25                  30                    

tac tgg gcc tgg atc cgg aag ttc cca gga aat aaa atg gag tgg atg        144
Tyr Trp Ala Trp Ile Arg Lys Phe Pro Gly Asn Lys Met Glu Trp Met           
        35                  40                  45                        

gga cac ata acc tac agt ggt tac act acc tac aat cca tct ctc aaa        192
Gly His Ile Thr Tyr Ser Gly Tyr Thr Thr Tyr Asn Pro Ser Leu Lys           
    50                  55                  60                            

agt cga atc tcc att act aga gac aca tcg agg aat cag ttc ttc ctc        240
Ser Arg Ile Ser Ile Thr Arg Asp Thr Ser Arg Asn Gln Phe Phe Leu           
65                  70                  75                  80            

cag ttg aac tct gta act act gag gac aca gcc act tat tac tgt gca        288
Gln Leu Asn Ser Val Thr Thr Glu Asp Thr Ala Thr Tyr Tyr Cys Ala           
                85                  90                  95                

aga ggt gga ggc ggt tca ggc gga ggt ggc tct ggc ggt ggc gga tcg        336
Arg Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser           
            100                 105                 110                   

aac att gta atg acc caa tct ccc aaa tcc atg tcc atg tca gta gga        384
Asn Ile Val Met Thr Gln Ser Pro Lys Ser Met Ser Met Ser Val Gly           
        115                 120                 125                       

gag agg gtc acc ttg acc tgc aag gcc agt gag aat gtg gtt act tat        432
Glu Arg Val Thr Leu Thr Cys Lys Ala Ser Glu Asn Val Val Thr Tyr           
    130                 135                 140                           

gtt tcc tgg tat caa cag aaa cca gag cag tct cct aaa ctg ctg ata        480
Val Ser Trp Tyr Gln Gln Lys Pro Glu Gln Ser Pro Lys Leu Leu Ile           
145                 150                 155                 160           

tac ggg gca tcc aac cgg tac act ggg gtc ccc gat cgc ttc aca ggc        528
Tyr Gly Ala Ser Asn Arg Tyr Thr Gly Val Pro Asp Arg Phe Thr Gly           
                165                 170                 175               

agt gga tct gca aca gat ttc act ctg acc atc agc agt gtg cag gct        576
Ser Gly Ser Ala Thr Asp Phe Thr Leu Thr Ile Ser Ser Val Gln Ala           
            180                 185                 190                   

gaa gac ctt gca gat tat cac tgt gga cag ggt tac agc tat ccg            621
Glu Asp Leu Ala Asp Tyr His Cys Gly Gln Gly Tyr Ser Tyr Pro               
        195                 200                 205                       


<210>  4
<211>  207
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  4

Glu Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Gln 
1               5                   10                  15      


Ser Leu Ser Leu Thr Cys Ser Val Thr Ala Tyr Phe Ile Thr Ser Asn 
            20                  25                  30          


Tyr Trp Ala Trp Ile Arg Lys Phe Pro Gly Asn Lys Met Glu Trp Met 
        35                  40                  45              


Gly His Ile Thr Tyr Ser Gly Tyr Thr Thr Tyr Asn Pro Ser Leu Lys 
    50                  55                  60                  


Ser Arg Ile Ser Ile Thr Arg Asp Thr Ser Arg Asn Gln Phe Phe Leu 
65                  70                  75                  80  


Gln Leu Asn Ser Val Thr Thr Glu Asp Thr Ala Thr Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
            100                 105                 110         


Asn Ile Val Met Thr Gln Ser Pro Lys Ser Met Ser Met Ser Val Gly 
        115                 120                 125             


Glu Arg Val Thr Leu Thr Cys Lys Ala Ser Glu Asn Val Val Thr Tyr 
    130                 135                 140                 


Val Ser Trp Tyr Gln Gln Lys Pro Glu Gln Ser Pro Lys Leu Leu Ile 
145                 150                 155                 160 


Tyr Gly Ala Ser Asn Arg Tyr Thr Gly Val Pro Asp Arg Phe Thr Gly 
                165                 170                 175     


Ser Gly Ser Ala Thr Asp Phe Thr Leu Thr Ile Ser Ser Val Gln Ala 
            180                 185                 190         


Glu Asp Leu Ala Asp Tyr His Cys Gly Gln Gly Tyr Ser Tyr Pro 
        195                 200                 205         


<210>  5
<211>  777
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Anti-CD3 2C11 scFv


<220>
<221>  CDS
<222>  (1)..(777)

<400>  5
atg gag aca gac aca ctc ctg cta tgg gta ctg ctg ctc tgg gtt cca         48
Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro           
1               5                   10                  15                

ggt tcc act ggt gac gag gtg cag ctg gtg gag tct ggg gga ggc ttg         96
Gly Ser Thr Gly Asp Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu           
            20                  25                  30                    

gtg cag cct gga aag tcc ctg aaa ctc tcc tgt gag gcc tct gga ttc        144
Val Gln Pro Gly Lys Ser Leu Lys Leu Ser Cys Glu Ala Ser Gly Phe           
        35                  40                  45                        

acc ttc agc ggc tat ggc atg cac tgg gtc cgc cag gct cca ggg agg        192
Thr Phe Ser Gly Tyr Gly Met His Trp Val Arg Gln Ala Pro Gly Arg           
    50                  55                  60                            

ggg ctg gag tcg gtc gca tac att act agt agt agt att aat atc aaa        240
Gly Leu Glu Ser Val Ala Tyr Ile Thr Ser Ser Ser Ile Asn Ile Lys           
65                  70                  75                  80            

tat gct gac gct gtg aaa ggc cgg ttc acc gtc tcc aga gac aat gcc        288
Tyr Ala Asp Ala Val Lys Gly Arg Phe Thr Val Ser Arg Asp Asn Ala           
                85                  90                  95                

aag aac tta ctg ttt cta caa atg aac att ctc aag tct gag gac aca        336
Lys Asn Leu Leu Phe Leu Gln Met Asn Ile Leu Lys Ser Glu Asp Thr           
            100                 105                 110                   

gcc atg tac tac tgt gca aga ttc gac tgg gac aaa aat tac tgg ggc        384
Ala Met Tyr Tyr Cys Ala Arg Phe Asp Trp Asp Lys Asn Tyr Trp Gly           
        115                 120                 125                       

caa gga acc atg gtc acc gtc tcc tca ggt gga ggc ggt tca ggc gga        432
Gln Gly Thr Met Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly           
    130                 135                 140                           

ggt ggc tct ggc ggt ggc gga tcg gac atc cag atg acc cag tct cca        480
Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Gln Met Thr Gln Ser Pro           
145                 150                 155                 160           

tca tca ctg cct gcc tcc ctg gga gac aga gtc act atc aat tgt cag        528
Ser Ser Leu Pro Ala Ser Leu Gly Asp Arg Val Thr Ile Asn Cys Gln           
                165                 170                 175               

gcc agt cag gac att agc aat tat tta aac tgg tac cag cag aaa cca        576
Ala Ser Gln Asp Ile Ser Asn Tyr Leu Asn Trp Tyr Gln Gln Lys Pro           
            180                 185                 190                   

ggg aaa gct cct aag ctc ctg atc tat tat aca aat aaa ttg gca gat        624
Gly Lys Ala Pro Lys Leu Leu Ile Tyr Tyr Thr Asn Lys Leu Ala Asp           
        195                 200                 205                       

gga gtc cca tca agg ttc agt ggc agt ggt tct ggg aga gat tct tct        672
Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Arg Asp Ser Ser           
    210                 215                 220                           

ttc act atc agc agc ctg gaa tcc gaa gat att gga tct tat tac tgt        720
Phe Thr Ile Ser Ser Leu Glu Ser Glu Asp Ile Gly Ser Tyr Tyr Cys           
225                 230                 235                 240           

caa cag tat tat aac tat ccg tgg acg ttc gga cct ggc acc aag ctg        768
Gln Gln Tyr Tyr Asn Tyr Pro Trp Thr Phe Gly Pro Gly Thr Lys Leu           
                245                 250                 255               

gaa atc aaa                                                            777
Glu Ile Lys                                                               
                                                                          


<210>  6
<211>  259
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  6

Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 
1               5                   10                  15      


Gly Ser Thr Gly Asp Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu 
            20                  25                  30          


Val Gln Pro Gly Lys Ser Leu Lys Leu Ser Cys Glu Ala Ser Gly Phe 
        35                  40                  45              


Thr Phe Ser Gly Tyr Gly Met His Trp Val Arg Gln Ala Pro Gly Arg 
    50                  55                  60                  


Gly Leu Glu Ser Val Ala Tyr Ile Thr Ser Ser Ser Ile Asn Ile Lys 
65                  70                  75                  80  


Tyr Ala Asp Ala Val Lys Gly Arg Phe Thr Val Ser Arg Asp Asn Ala 
                85                  90                  95      


Lys Asn Leu Leu Phe Leu Gln Met Asn Ile Leu Lys Ser Glu Asp Thr 
            100                 105                 110         


Ala Met Tyr Tyr Cys Ala Arg Phe Asp Trp Asp Lys Asn Tyr Trp Gly 
        115                 120                 125             


Gln Gly Thr Met Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly 
    130                 135                 140                 


Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Gln Met Thr Gln Ser Pro 
145                 150                 155                 160 


Ser Ser Leu Pro Ala Ser Leu Gly Asp Arg Val Thr Ile Asn Cys Gln 
                165                 170                 175     


Ala Ser Gln Asp Ile Ser Asn Tyr Leu Asn Trp Tyr Gln Gln Lys Pro 
            180                 185                 190         


Gly Lys Ala Pro Lys Leu Leu Ile Tyr Tyr Thr Asn Lys Leu Ala Asp 
        195                 200                 205             


Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Arg Asp Ser Ser 
    210                 215                 220                 


Phe Thr Ile Ser Ser Leu Glu Ser Glu Asp Ile Gly Ser Tyr Tyr Cys 
225                 230                 235                 240 


Gln Gln Tyr Tyr Asn Tyr Pro Trp Thr Phe Gly Pro Gly Thr Lys Leu 
                245                 250                 255     


Glu Ile Lys 
            


<210>  7
<211>  762
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Anti-c-myc scFv


<220>
<221>  CDS
<222>  (1)..(762)

<400>  7
atg gag gtg cac ctg gtg gag tct ggg gga gac tta gtg aag cct gga         48
Met Glu Val His Leu Val Glu Ser Gly Gly Asp Leu Val Lys Pro Gly           
1               5                   10                  15                

ggg tcc ctg aaa ctc tcc tgt gca gcc tct gga ttc act ttc agt cac         96
Gly Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser His           
            20                  25                  30                    

tat ggc atg tct tgg gtt cgc cag act cca gac aag agg ctg gag tgg        144
Tyr Gly Met Ser Trp Val Arg Gln Thr Pro Asp Lys Arg Leu Glu Trp           
        35                  40                  45                        

gtc gca acc att ggt agt cgt ggt act tac acc cac tat cca gac agt        192
Val Ala Thr Ile Gly Ser Arg Gly Thr Tyr Thr His Tyr Pro Asp Ser           
    50                  55                  60                            

gtg aag gga cga ttc acc atc tcc aga gac aat gac aag aac gcc ctg        240
Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Asp Lys Asn Ala Leu           
65                  70                  75                  80            

tac ctg caa atg aac agt ctg aag tct gaa gac aca gcc atg tat tac        288
Tyr Leu Gln Met Asn Ser Leu Lys Ser Glu Asp Thr Ala Met Tyr Tyr           
                85                  90                  95                

tgt gca aga aga agt gaa ttt tat tac tac ggt aat acc tac tat tac        336
Cys Ala Arg Arg Ser Glu Phe Tyr Tyr Tyr Gly Asn Thr Tyr Tyr Tyr           
            100                 105                 110                   

tct gct atg gac tac tgg ggt caa gga gcc tca gtc acc gtc tcc tca        384
Ser Ala Met Asp Tyr Trp Gly Gln Gly Ala Ser Val Thr Val Ser Ser           
        115                 120                 125                       

ggt gga ggc ggt tca ggc gga ggt ggc tct ggc ggt ggc gga tcg gac        432
Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp           
    130                 135                 140                           

att gtg ctg acc caa tct cca gct tct ttg gct gta tct cta gga cag        480
Ile Val Leu Thr Gln Ser Pro Ala Ser Leu Ala Val Ser Leu Gly Gln           
145                 150                 155                 160           

agg gcc acc atc tcc tgc aga gcc agc gaa agt gtt gat aat tat ggc        528
Arg Ala Thr Ile Ser Cys Arg Ala Ser Glu Ser Val Asp Asn Tyr Gly           
                165                 170                 175               

ttt agt ttt atg aac tgg ttc caa cag aaa cca gga cag cca ccc aaa        576
Phe Ser Phe Met Asn Trp Phe Gln Gln Lys Pro Gly Gln Pro Pro Lys           
            180                 185                 190                   

ctc ctc atc tat gct ata tcc aac cga gga tcc ggg gtc cct gcc agg        624
Leu Leu Ile Tyr Ala Ile Ser Asn Arg Gly Ser Gly Val Pro Ala Arg           
        195                 200                 205                       

ttt agt ggc agt ggg tct ggg aca gac ttc agc ctc aac atc cat cct        672
Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Ser Leu Asn Ile His Pro           
    210                 215                 220                           

gta gag gag gat gat cct gca atg tat ttc tgt cag caa act aag gag        720
Val Glu Glu Asp Asp Pro Ala Met Tyr Phe Cys Gln Gln Thr Lys Glu           
225                 230                 235                 240           

gtt ccg tgg acg ttc ggt gga ggc acc aag ctg gaa atc aaa                762
Val Pro Trp Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys                   
                245                 250                                   


<210>  8
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  8

Met Glu Val His Leu Val Glu Ser Gly Gly Asp Leu Val Lys Pro Gly 
1               5                   10                  15      


Gly Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser His 
            20                  25                  30          


Tyr Gly Met Ser Trp Val Arg Gln Thr Pro Asp Lys Arg Leu Glu Trp 
        35                  40                  45              


Val Ala Thr Ile Gly Ser Arg Gly Thr Tyr Thr His Tyr Pro Asp Ser 
    50                  55                  60                  


Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Asp Lys Asn Ala Leu 
65                  70                  75                  80  


Tyr Leu Gln Met Asn Ser Leu Lys Ser Glu Asp Thr Ala Met Tyr Tyr 
                85                  90                  95      


Cys Ala Arg Arg Ser Glu Phe Tyr Tyr Tyr Gly Asn Thr Tyr Tyr Tyr 
            100                 105                 110         


Ser Ala Met Asp Tyr Trp Gly Gln Gly Ala Ser Val Thr Val Ser Ser 
        115                 120                 125             


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp 
    130                 135                 140                 


Ile Val Leu Thr Gln Ser Pro Ala Ser Leu Ala Val Ser Leu Gly Gln 
145                 150                 155                 160 


Arg Ala Thr Ile Ser Cys Arg Ala Ser Glu Ser Val Asp Asn Tyr Gly 
                165                 170                 175     


Phe Ser Phe Met Asn Trp Phe Gln Gln Lys Pro Gly Gln Pro Pro Lys 
            180                 185                 190         


Leu Leu Ile Tyr Ala Ile Ser Asn Arg Gly Ser Gly Val Pro Ala Arg 
        195                 200                 205             


Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Ser Leu Asn Ile His Pro 
    210                 215                 220                 


Val Glu Glu Asp Asp Pro Ala Met Tyr Phe Cys Gln Gln Thr Lys Glu 
225                 230                 235                 240 


Val Pro Trp Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
                245                 250                 


<210>  9
<211>  15
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Linker 1


<220>
<221>  CDS
<222>  (1)..(15)

<400>  9
ggt gga ggc ggt tca                                                     15
Gly Gly Gly Gly Ser                                                       
1               5                                                         


<210>  10
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  10

Gly Gly Gly Gly Ser 
1               5   


<210>  11
<211>  45
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Linker 2


<220>
<221>  CDS
<222>  (1)..(45)

<400>  11
ggt gga ggc ggt tca ggc gga ggt ggc tct ggc ggt ggc gga tcg             45
Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser               
1               5                   10                  15                


<210>  12
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  12

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
1               5                   10                  15  


<210>  13
<211>  90
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Linker 3


<220>
<221>  CDS
<222>  (1)..(90)

<400>  13
ggt gga ggc ggt tca ggc gga ggt ggc tct ggc ggt ggc gga tcg ggt         48
Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly           
1               5                   10                  15                

gga ggc ggt tca ggc gga ggt ggc tct ggc ggt ggc gga tcg                 90
Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser                   
            20                  25                  30                    


<210>  14
<211>  30
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  14

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
1               5                   10                  15      


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
            20                  25                  30  


<210>  15
<211>  1524
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  BEAT 1 CD40/c-myc-tag


<220>
<221>  CDS
<222>  (1)..(1524)

<400>  15
atg gag gtg cac ctg gtg gag tct ggg gga gac tta gtg aag cct gga         48
Met Glu Val His Leu Val Glu Ser Gly Gly Asp Leu Val Lys Pro Gly           
1               5                   10                  15                

ggg tcc ctg aaa ctc tcc tgt gca gcc tct gga ttc act ttc agt cac         96
Gly Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser His           
            20                  25                  30                    

tat ggc atg tct tgg gtt cgc cag act cca gac aag agg ctg gag tgg        144
Tyr Gly Met Ser Trp Val Arg Gln Thr Pro Asp Lys Arg Leu Glu Trp           
        35                  40                  45                        

gtc gca acc att ggt agt cgt ggt act tac acc cac tat cca gac agt        192
Val Ala Thr Ile Gly Ser Arg Gly Thr Tyr Thr His Tyr Pro Asp Ser           
    50                  55                  60                            

gtg aag gga cga ttc acc atc tcc aga gac aat gac aag aac gcc ctg        240
Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Asp Lys Asn Ala Leu           
65                  70                  75                  80            

tac ctg caa atg aac agt ctg aag tct gaa gac aca gcc atg tat tac        288
Tyr Leu Gln Met Asn Ser Leu Lys Ser Glu Asp Thr Ala Met Tyr Tyr           
                85                  90                  95                

tgt gca aga aga agt gaa ttt tat tac tac ggt aat acc tac tat tac        336
Cys Ala Arg Arg Ser Glu Phe Tyr Tyr Tyr Gly Asn Thr Tyr Tyr Tyr           
            100                 105                 110                   

tct gct atg gac tac tgg ggt caa gga gcc tca gtc acc gtc tcc tca        384
Ser Ala Met Asp Tyr Trp Gly Gln Gly Ala Ser Val Thr Val Ser Ser           
        115                 120                 125                       

ggt gga ggc ggt tca ggc gga ggt ggc tct ggc ggt ggc gga tcg gac        432
Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp           
    130                 135                 140                           

att gtg ctg acc caa tct cca gct tct ttg gct gta tct cta gga cag        480
Ile Val Leu Thr Gln Ser Pro Ala Ser Leu Ala Val Ser Leu Gly Gln           
145                 150                 155                 160           

agg gcc acc atc tcc tgc aga gcc agc gaa agt gtt gat aat tat ggc        528
Arg Ala Thr Ile Ser Cys Arg Ala Ser Glu Ser Val Asp Asn Tyr Gly           
                165                 170                 175               

ttt agt ttt atg aac tgg ttc caa cag aaa cca gga cag cca ccc aaa        576
Phe Ser Phe Met Asn Trp Phe Gln Gln Lys Pro Gly Gln Pro Pro Lys           
            180                 185                 190                   

ctc ctc atc tat gct ata tcc aac cga gga tcc ggg gtc cct gcc agg        624
Leu Leu Ile Tyr Ala Ile Ser Asn Arg Gly Ser Gly Val Pro Ala Arg           
        195                 200                 205                       

ttt agt ggc agt ggg tct ggg aca gac ttc agc ctc aac atc cat cct        672
Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Ser Leu Asn Ile His Pro           
    210                 215                 220                           

gta gag gag gat gat cct gca atg tat ttc tgt cag caa act aag gag        720
Val Glu Glu Asp Asp Pro Ala Met Tyr Phe Cys Gln Gln Thr Lys Glu           
225                 230                 235                 240           

gtt ccg tgg acg ttc ggt gga ggc acc aag ctg gaa atc aaa ggt gga        768
Val Pro Trp Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Gly Gly           
                245                 250                 255               

ggc ggt tca atg gag gtg cag gtg gtg gag tct gat gga ggc tta gtg        816
Gly Gly Ser Met Glu Val Gln Val Val Glu Ser Asp Gly Gly Leu Val           
            260                 265                 270                   

cag cct gga agg tcc cta aaa ctc ccc tgt gca gcc tca gga ttc act        864
Gln Pro Gly Arg Ser Leu Lys Leu Pro Cys Ala Ala Ser Gly Phe Thr           
        275                 280                 285                       

ttc agt gac tat tac atg gcc tgg gtc cgc cag gct cca acg aag ggg        912
Phe Ser Asp Tyr Tyr Met Ala Trp Val Arg Gln Ala Pro Thr Lys Gly           
    290                 295                 300                           

ctg gag tgg gtc gca agc att agt tat gat ggt agt agc act tac tat        960
Leu Glu Trp Val Ala Ser Ile Ser Tyr Asp Gly Ser Ser Thr Tyr Tyr           
305                 310                 315                 320           

cga gac tcc gtg aag ggc cga ttc act atc tcc aga gat aat gca aaa       1008
Arg Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys           
                325                 330                 335               

agc acc cta tac ctg caa atg gac agt ctg agg tct gag gac acg gcc       1056
Ser Thr Leu Tyr Leu Gln Met Asp Ser Leu Arg Ser Glu Asp Thr Ala           
            340                 345                 350                   

act tat tac tgc gga aga cac agt agc tac ttt gat tac tgg ggc caa       1104
Thr Tyr Tyr Cys Gly Arg His Ser Ser Tyr Phe Asp Tyr Trp Gly Gln           
        355                 360                 365                       

gga gtc atg gtc aca gtc tcc tca ggt gga ggc ggt tca ggc gga ggt       1152
Gly Val Met Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly           
    370                 375                 380                           

ggc tct ggc ggt ggc gga tcg gac act gta ctg acc cag tct cct gct       1200
Gly Ser Gly Gly Gly Gly Ser Asp Thr Val Leu Thr Gln Ser Pro Ala           
385                 390                 395                 400           

ttg gct gtg tct cca gga gag agg gtt acc atc tcc tgt agg gcc agt       1248
Leu Ala Val Ser Pro Gly Glu Arg Val Thr Ile Ser Cys Arg Ala Ser           
                405                 410                 415               

gac agt gtc agt aca ctt atg cac tgg tac caa cag aaa cca gga cag       1296
Asp Ser Val Ser Thr Leu Met His Trp Tyr Gln Gln Lys Pro Gly Gln           
            420                 425                 430                   

caa ccc aaa ctc ctc atc tat cta gca tca cac cta gaa tct ggg gtc       1344
Gln Pro Lys Leu Leu Ile Tyr Leu Ala Ser His Leu Glu Ser Gly Val           
        435                 440                 445                       

cct gcc agg ttc agt ggc agt ggg tct ggg aca gac ttc acc ctc acc       1392
Pro Ala Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr           
    450                 455                 460                           

att gat cct gtg gag gct gat gac act gca acc tat tac tgt cag cag       1440
Ile Asp Pro Val Glu Ala Asp Asp Thr Ala Thr Tyr Tyr Cys Gln Gln           
465                 470                 475                 480           

agt tgg aat gat ccg tgg acg ttc ggt gga ggc acc aag ctg gaa ttg       1488
Ser Trp Asn Asp Pro Trp Thr Phe Gly Gly Gly Thr Lys Leu Glu Leu           
                485                 490                 495               

aaa aat ggg gcc gtc gag cac cac cac cac cac cac                       1524
Lys Asn Gly Ala Val Glu His His His His His His                           
            500                 505                                       


<210>  16
<211>  508
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  16

Met Glu Val His Leu Val Glu Ser Gly Gly Asp Leu Val Lys Pro Gly 
1               5                   10                  15      


Gly Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser His 
            20                  25                  30          


Tyr Gly Met Ser Trp Val Arg Gln Thr Pro Asp Lys Arg Leu Glu Trp 
        35                  40                  45              


Val Ala Thr Ile Gly Ser Arg Gly Thr Tyr Thr His Tyr Pro Asp Ser 
    50                  55                  60                  


Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Asp Lys Asn Ala Leu 
65                  70                  75                  80  


Tyr Leu Gln Met Asn Ser Leu Lys Ser Glu Asp Thr Ala Met Tyr Tyr 
                85                  90                  95      


Cys Ala Arg Arg Ser Glu Phe Tyr Tyr Tyr Gly Asn Thr Tyr Tyr Tyr 
            100                 105                 110         


Ser Ala Met Asp Tyr Trp Gly Gln Gly Ala Ser Val Thr Val Ser Ser 
        115                 120                 125             


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp 
    130                 135                 140                 


Ile Val Leu Thr Gln Ser Pro Ala Ser Leu Ala Val Ser Leu Gly Gln 
145                 150                 155                 160 


Arg Ala Thr Ile Ser Cys Arg Ala Ser Glu Ser Val Asp Asn Tyr Gly 
                165                 170                 175     


Phe Ser Phe Met Asn Trp Phe Gln Gln Lys Pro Gly Gln Pro Pro Lys 
            180                 185                 190         


Leu Leu Ile Tyr Ala Ile Ser Asn Arg Gly Ser Gly Val Pro Ala Arg 
        195                 200                 205             


Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Ser Leu Asn Ile His Pro 
    210                 215                 220                 


Val Glu Glu Asp Asp Pro Ala Met Tyr Phe Cys Gln Gln Thr Lys Glu 
225                 230                 235                 240 


Val Pro Trp Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Gly Gly 
                245                 250                 255     


Gly Gly Ser Met Glu Val Gln Val Val Glu Ser Asp Gly Gly Leu Val 
            260                 265                 270         


Gln Pro Gly Arg Ser Leu Lys Leu Pro Cys Ala Ala Ser Gly Phe Thr 
        275                 280                 285             


Phe Ser Asp Tyr Tyr Met Ala Trp Val Arg Gln Ala Pro Thr Lys Gly 
    290                 295                 300                 


Leu Glu Trp Val Ala Ser Ile Ser Tyr Asp Gly Ser Ser Thr Tyr Tyr 
305                 310                 315                 320 


Arg Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys 
                325                 330                 335     


Ser Thr Leu Tyr Leu Gln Met Asp Ser Leu Arg Ser Glu Asp Thr Ala 
            340                 345                 350         


Thr Tyr Tyr Cys Gly Arg His Ser Ser Tyr Phe Asp Tyr Trp Gly Gln 
        355                 360                 365             


Gly Val Met Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly 
    370                 375                 380                 


Gly Ser Gly Gly Gly Gly Ser Asp Thr Val Leu Thr Gln Ser Pro Ala 
385                 390                 395                 400 


Leu Ala Val Ser Pro Gly Glu Arg Val Thr Ile Ser Cys Arg Ala Ser 
                405                 410                 415     


Asp Ser Val Ser Thr Leu Met His Trp Tyr Gln Gln Lys Pro Gly Gln 
            420                 425                 430         


Gln Pro Lys Leu Leu Ile Tyr Leu Ala Ser His Leu Glu Ser Gly Val 
        435                 440                 445             


Pro Ala Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
    450                 455                 460                 


Ile Asp Pro Val Glu Ala Asp Asp Thr Ala Thr Tyr Tyr Cys Gln Gln 
465                 470                 475                 480 


Ser Trp Asn Asp Pro Trp Thr Phe Gly Gly Gly Thr Lys Leu Glu Leu 
                485                 490                 495     


Lys Asn Gly Ala Val Glu His His His His His His 
            500                 505             


<210>  17
<211>  1401
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  BEAT 2 MHCII-c-myc-tag


<220>
<221>  CDS
<222>  (1)..(1398)

<400>  17
atg gag gtg cac ctg gtg gag tct ggg gga gac tta gtg aag cct gga         48
Met Glu Val His Leu Val Glu Ser Gly Gly Asp Leu Val Lys Pro Gly           
1               5                   10                  15                

ggg tcc ctg aaa ctc tcc tgt gca gcc tct gga ttc act ttc agt cac         96
Gly Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser His           
            20                  25                  30                    

tat ggc atg tct tgg gtt cgc cag act cca gac aag agg ctg gag tgg        144
Tyr Gly Met Ser Trp Val Arg Gln Thr Pro Asp Lys Arg Leu Glu Trp           
        35                  40                  45                        

gtc gca acc att ggt agt cgt ggt act tac acc cac tat cca gac agt        192
Val Ala Thr Ile Gly Ser Arg Gly Thr Tyr Thr His Tyr Pro Asp Ser           
    50                  55                  60                            

gtg aag gga cga ttc acc atc tcc aga gac aat gac aag aac gcc ctg        240
Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Asp Lys Asn Ala Leu           
65                  70                  75                  80            

tac ctg caa atg aac agt ctg aag tct gaa gac aca gcc atg tat tac        288
Tyr Leu Gln Met Asn Ser Leu Lys Ser Glu Asp Thr Ala Met Tyr Tyr           
                85                  90                  95                

tgt gca aga aga agt gaa ttt tat tac tac ggt aat acc tac tat tac        336
Cys Ala Arg Arg Ser Glu Phe Tyr Tyr Tyr Gly Asn Thr Tyr Tyr Tyr           
            100                 105                 110                   

tct gct atg gac tac tgg ggt caa gga gcc tca gtc acc gtc tcc tca        384
Ser Ala Met Asp Tyr Trp Gly Gln Gly Ala Ser Val Thr Val Ser Ser           
        115                 120                 125                       

ggt gga ggc ggt tca ggc gga ggt ggc tct ggc ggt ggc gga tcg gac        432
Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp           
    130                 135                 140                           

att gtg ctg acc caa tct cca gct tct ttg gct gta tct cta gga cag        480
Ile Val Leu Thr Gln Ser Pro Ala Ser Leu Ala Val Ser Leu Gly Gln           
145                 150                 155                 160           

agg gcc acc atc tcc tgc aga gcc agc gaa agt gtt gat aat tat ggc        528
Arg Ala Thr Ile Ser Cys Arg Ala Ser Glu Ser Val Asp Asn Tyr Gly           
                165                 170                 175               

ttt agt ttt atg aac tgg ttc caa cag aaa cca gga cag cca ccc aaa        576
Phe Ser Phe Met Asn Trp Phe Gln Gln Lys Pro Gly Gln Pro Pro Lys           
            180                 185                 190                   

ctc ctc atc tat gct ata tcc aac cga gga tcc ggg gtc cct gcc agg        624
Leu Leu Ile Tyr Ala Ile Ser Asn Arg Gly Ser Gly Val Pro Ala Arg           
        195                 200                 205                       

ttt agt ggc agt ggg tct ggg aca gac ttc agc ctc aac atc cat cct        672
Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Ser Leu Asn Ile His Pro           
    210                 215                 220                           

gta gag gag gat gat cct gca atg tat ttc tgt cag caa act aag gag        720
Val Glu Glu Asp Asp Pro Ala Met Tyr Phe Cys Gln Gln Thr Lys Glu           
225                 230                 235                 240           

gtt ccg tgg acg ttc ggt gga ggc acc aag ctg gaa atc aaa ggt gga        768
Val Pro Trp Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Gly Gly           
                245                 250                 255               

ggc ggt tca gag gtg cag ctt cag gag tca gga cct ggc ctt gtg aaa        816
Gly Gly Ser Glu Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys           
            260                 265                 270                   

ccc tca cag tca ctc tcc ctc acc tgt tct gtc act gct tac ttc atc        864
Pro Ser Gln Ser Leu Ser Leu Thr Cys Ser Val Thr Ala Tyr Phe Ile           
        275                 280                 285                       

act agt aat tac tgg gcc tgg atc cgg aag ttc cca gga aat aaa atg        912
Thr Ser Asn Tyr Trp Ala Trp Ile Arg Lys Phe Pro Gly Asn Lys Met           
    290                 295                 300                           

gag tgg atg gga cac ata acc tac agt ggt tac act acc tac aat cca        960
Glu Trp Met Gly His Ile Thr Tyr Ser Gly Tyr Thr Thr Tyr Asn Pro           
305                 310                 315                 320           

tct ctc aaa agt cga atc tcc att act aga gac aca tcg agg aat cag       1008
Ser Leu Lys Ser Arg Ile Ser Ile Thr Arg Asp Thr Ser Arg Asn Gln           
                325                 330                 335               

ttc ttc ctc cag ttg aac tct gta act act gag gac aca gcc act tat       1056
Phe Phe Leu Gln Leu Asn Ser Val Thr Thr Glu Asp Thr Ala Thr Tyr           
            340                 345                 350                   

tac tgt gca aga ggt gga ggc ggt tca ggc gga ggt ggc tct ggc ggt       1104
Tyr Cys Ala Arg Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly           
        355                 360                 365                       

ggc gga tcg aac att gta atg acc caa tct ccc aaa tcc atg tcc atg       1152
Gly Gly Ser Asn Ile Val Met Thr Gln Ser Pro Lys Ser Met Ser Met           
    370                 375                 380                           

tca gta gga gag agg gtc acc ttg acc tgc aag gcc agt gag aat gtg       1200
Ser Val Gly Glu Arg Val Thr Leu Thr Cys Lys Ala Ser Glu Asn Val           
385                 390                 395                 400           

gtt act tat gtt tcc tgg tat caa cag aaa cca gag cag tct cct aaa       1248
Val Thr Tyr Val Ser Trp Tyr Gln Gln Lys Pro Glu Gln Ser Pro Lys           
                405                 410                 415               

ctg ctg ata tac ggg gca tcc aac cgg tac act ggg gtc ccc gat cgc       1296
Leu Leu Ile Tyr Gly Ala Ser Asn Arg Tyr Thr Gly Val Pro Asp Arg           
            420                 425                 430                   

ttc aca ggc agt gga tct gca aca gat ttc act ctg acc atc agc agt       1344
Phe Thr Gly Ser Gly Ser Ala Thr Asp Phe Thr Leu Thr Ile Ser Ser           
        435                 440                 445                       

gtg cag gct gaa gac ctt gca gat tat cac tgt gga cag ggt tac agc       1392
Val Gln Ala Glu Asp Leu Ala Asp Tyr His Cys Gly Gln Gly Tyr Ser           
    450                 455                 460                           

tat ccg taa                                                           1401
Tyr Pro                                                                   
465                                                                       


<210>  18
<211>  466
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  18

Met Glu Val His Leu Val Glu Ser Gly Gly Asp Leu Val Lys Pro Gly 
1               5                   10                  15      


Gly Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser His 
            20                  25                  30          


Tyr Gly Met Ser Trp Val Arg Gln Thr Pro Asp Lys Arg Leu Glu Trp 
        35                  40                  45              


Val Ala Thr Ile Gly Ser Arg Gly Thr Tyr Thr His Tyr Pro Asp Ser 
    50                  55                  60                  


Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Asp Lys Asn Ala Leu 
65                  70                  75                  80  


Tyr Leu Gln Met Asn Ser Leu Lys Ser Glu Asp Thr Ala Met Tyr Tyr 
                85                  90                  95      


Cys Ala Arg Arg Ser Glu Phe Tyr Tyr Tyr Gly Asn Thr Tyr Tyr Tyr 
            100                 105                 110         


Ser Ala Met Asp Tyr Trp Gly Gln Gly Ala Ser Val Thr Val Ser Ser 
        115                 120                 125             


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp 
    130                 135                 140                 


Ile Val Leu Thr Gln Ser Pro Ala Ser Leu Ala Val Ser Leu Gly Gln 
145                 150                 155                 160 


Arg Ala Thr Ile Ser Cys Arg Ala Ser Glu Ser Val Asp Asn Tyr Gly 
                165                 170                 175     


Phe Ser Phe Met Asn Trp Phe Gln Gln Lys Pro Gly Gln Pro Pro Lys 
            180                 185                 190         


Leu Leu Ile Tyr Ala Ile Ser Asn Arg Gly Ser Gly Val Pro Ala Arg 
        195                 200                 205             


Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Ser Leu Asn Ile His Pro 
    210                 215                 220                 


Val Glu Glu Asp Asp Pro Ala Met Tyr Phe Cys Gln Gln Thr Lys Glu 
225                 230                 235                 240 


Val Pro Trp Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Gly Gly 
                245                 250                 255     


Gly Gly Ser Glu Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys 
            260                 265                 270         


Pro Ser Gln Ser Leu Ser Leu Thr Cys Ser Val Thr Ala Tyr Phe Ile 
        275                 280                 285             


Thr Ser Asn Tyr Trp Ala Trp Ile Arg Lys Phe Pro Gly Asn Lys Met 
    290                 295                 300                 


Glu Trp Met Gly His Ile Thr Tyr Ser Gly Tyr Thr Thr Tyr Asn Pro 
305                 310                 315                 320 


Ser Leu Lys Ser Arg Ile Ser Ile Thr Arg Asp Thr Ser Arg Asn Gln 
                325                 330                 335     


Phe Phe Leu Gln Leu Asn Ser Val Thr Thr Glu Asp Thr Ala Thr Tyr 
            340                 345                 350         


Tyr Cys Ala Arg Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
        355                 360                 365             


Gly Gly Ser Asn Ile Val Met Thr Gln Ser Pro Lys Ser Met Ser Met 
    370                 375                 380                 


Ser Val Gly Glu Arg Val Thr Leu Thr Cys Lys Ala Ser Glu Asn Val 
385                 390                 395                 400 


Val Thr Tyr Val Ser Trp Tyr Gln Gln Lys Pro Glu Gln Ser Pro Lys 
                405                 410                 415     


Leu Leu Ile Tyr Gly Ala Ser Asn Arg Tyr Thr Gly Val Pro Asp Arg 
            420                 425                 430         


Phe Thr Gly Ser Gly Ser Ala Thr Asp Phe Thr Leu Thr Ile Ser Ser 
        435                 440                 445             


Val Gln Ala Glu Asp Leu Ala Asp Tyr His Cys Gly Gln Gly Tyr Ser 
    450                 455                 460                 


Tyr Pro 
465     


<210>  19
<211>  1542
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  BEAT 3 CD40-anti-CD3


<220>
<221>  CDS
<222>  (1)..(1539)

<400>  19
atg gag aca gac aca ctc ctg cta tgg gta ctg ctg ctc tgg gtt cca         48
Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro           
1               5                   10                  15                

ggt tcc act ggt gac gag gtg cag ctg gtg gag tct ggg gga ggc ttg         96
Gly Ser Thr Gly Asp Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu           
            20                  25                  30                    

gtg cag cct gga aag tcc ctg aaa ctc tcc tgt gag gcc tct gga ttc        144
Val Gln Pro Gly Lys Ser Leu Lys Leu Ser Cys Glu Ala Ser Gly Phe           
        35                  40                  45                        

acc ttc agc ggc tat ggc atg cac tgg gtc cgc cag gct cca ggg agg        192
Thr Phe Ser Gly Tyr Gly Met His Trp Val Arg Gln Ala Pro Gly Arg           
    50                  55                  60                            

ggg ctg gag tcg gtc gca tac att act agt agt agt att aat atc aaa        240
Gly Leu Glu Ser Val Ala Tyr Ile Thr Ser Ser Ser Ile Asn Ile Lys           
65                  70                  75                  80            

tat gct gac gct gtg aaa ggc cgg ttc acc gtc tcc aga gac aat gcc        288
Tyr Ala Asp Ala Val Lys Gly Arg Phe Thr Val Ser Arg Asp Asn Ala           
                85                  90                  95                

aag aac tta ctg ttt cta caa atg aac att ctc aag tct gag gac aca        336
Lys Asn Leu Leu Phe Leu Gln Met Asn Ile Leu Lys Ser Glu Asp Thr           
            100                 105                 110                   

gcc atg tac tac tgt gca aga ttc gac tgg gac aaa aat tac tgg ggc        384
Ala Met Tyr Tyr Cys Ala Arg Phe Asp Trp Asp Lys Asn Tyr Trp Gly           
        115                 120                 125                       

caa gga acc atg gtc acc gtc tcc tca ggt gga ggc ggt tca ggc gga        432
Gln Gly Thr Met Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly           
    130                 135                 140                           

ggt ggc tct ggc ggt ggc gga tcg gac atc cag atg acc cag tct cca        480
Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Gln Met Thr Gln Ser Pro           
145                 150                 155                 160           

tca tca ctg cct gcc tcc ctg gga gac aga gtc act atc aat tgt cag        528
Ser Ser Leu Pro Ala Ser Leu Gly Asp Arg Val Thr Ile Asn Cys Gln           
                165                 170                 175               

gcc agt cag gac att agc aat tat tta aac tgg tac cag cag aaa cca        576
Ala Ser Gln Asp Ile Ser Asn Tyr Leu Asn Trp Tyr Gln Gln Lys Pro           
            180                 185                 190                   

ggg aaa gct cct aag ctc ctg atc tat tat aca aat aaa ttg gca gat        624
Gly Lys Ala Pro Lys Leu Leu Ile Tyr Tyr Thr Asn Lys Leu Ala Asp           
        195                 200                 205                       

gga gtc cca tca agg ttc agt ggc agt ggt tct ggg aga gat tct tct        672
Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Arg Asp Ser Ser           
    210                 215                 220                           

ttc act atc agc agc ctg gaa tcc gaa gat att gga tct tat tac tgt        720
Phe Thr Ile Ser Ser Leu Glu Ser Glu Asp Ile Gly Ser Tyr Tyr Cys           
225                 230                 235                 240           

caa cag tat tat aac tat ccg tgg acg ttc gga cct ggc acc aag ctg        768
Gln Gln Tyr Tyr Asn Tyr Pro Trp Thr Phe Gly Pro Gly Thr Lys Leu           
                245                 250                 255               

gaa atc aaa ggt gga ggc ggt tca atg gag gtg cag gtg gtg gag tct        816
Glu Ile Lys Gly Gly Gly Gly Ser Met Glu Val Gln Val Val Glu Ser           
            260                 265                 270                   

gat gga ggc tta gtg cag cct gga agg tcc cta aaa ctc ccc tgt gca        864
Asp Gly Gly Leu Val Gln Pro Gly Arg Ser Leu Lys Leu Pro Cys Ala           
        275                 280                 285                       

gcc tca gga ttc act ttc agt gac tat tac atg gcc tgg gtc cgc cag        912
Ala Ser Gly Phe Thr Phe Ser Asp Tyr Tyr Met Ala Trp Val Arg Gln           
    290                 295                 300                           

gct cca acg aag ggg ctg gag tgg gtc gca agc att agt tat gat ggt        960
Ala Pro Thr Lys Gly Leu Glu Trp Val Ala Ser Ile Ser Tyr Asp Gly           
305                 310                 315                 320           

agt agc act tac tat cga gac tcc gtg aag ggc cga ttc act atc tcc       1008
Ser Ser Thr Tyr Tyr Arg Asp Ser Val Lys Gly Arg Phe Thr Ile Ser           
                325                 330                 335               

aga gat aat gca aaa agc acc cta tac ctg caa atg gac agt ctg agg       1056
Arg Asp Asn Ala Lys Ser Thr Leu Tyr Leu Gln Met Asp Ser Leu Arg           
            340                 345                 350                   

tct gag gac acg gcc act tat tac tgc gga aga cac agt agc tac ttt       1104
Ser Glu Asp Thr Ala Thr Tyr Tyr Cys Gly Arg His Ser Ser Tyr Phe           
        355                 360                 365                       

gat tac tgg ggc caa gga gtc atg gtc aca gtc tcc tca ggt gga ggc       1152
Asp Tyr Trp Gly Gln Gly Val Met Val Thr Val Ser Ser Gly Gly Gly           
    370                 375                 380                           

ggt tca ggc gga ggt ggc tct ggc ggt ggc gga tcg gac act gta ctg       1200
Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Thr Val Leu           
385                 390                 395                 400           

acc cag tct cct gct ttg gct gtg tct cca gga gag agg gtt acc atc       1248
Thr Gln Ser Pro Ala Leu Ala Val Ser Pro Gly Glu Arg Val Thr Ile           
                405                 410                 415               

tcc tgt agg gcc agt gac agt gtc agt aca ctt atg cac tgg tac caa       1296
Ser Cys Arg Ala Ser Asp Ser Val Ser Thr Leu Met His Trp Tyr Gln           
            420                 425                 430                   

cag aaa cca gga cag caa ccc aaa ctc ctc atc tat cta gca tca cac       1344
Gln Lys Pro Gly Gln Gln Pro Lys Leu Leu Ile Tyr Leu Ala Ser His           
        435                 440                 445                       

cta gaa tct ggg gtc cct gcc agg ttc agt ggc agt ggg tct ggg aca       1392
Leu Glu Ser Gly Val Pro Ala Arg Phe Ser Gly Ser Gly Ser Gly Thr           
    450                 455                 460                           

gac ttc acc ctc acc att gat cct gtg gag gct gat gac act gca acc       1440
Asp Phe Thr Leu Thr Ile Asp Pro Val Glu Ala Asp Asp Thr Ala Thr           
465                 470                 475                 480           

tat tac tgt cag cag agt tgg aat gat ccg tgg acg ttc ggt gga ggc       1488
Tyr Tyr Cys Gln Gln Ser Trp Asn Asp Pro Trp Thr Phe Gly Gly Gly           
                485                 490                 495               

acc aag ctg gaa ttg aaa aat ggg gcc gtc gag cac cac cac cac cac       1536
Thr Lys Leu Glu Leu Lys Asn Gly Ala Val Glu His His His His His           
            500                 505                 510                   

cac tga                                                               1542
His                                                                       
                                                                          


<210>  20
<211>  513
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  20

Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 
1               5                   10                  15      


Gly Ser Thr Gly Asp Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu 
            20                  25                  30          


Val Gln Pro Gly Lys Ser Leu Lys Leu Ser Cys Glu Ala Ser Gly Phe 
        35                  40                  45              


Thr Phe Ser Gly Tyr Gly Met His Trp Val Arg Gln Ala Pro Gly Arg 
    50                  55                  60                  


Gly Leu Glu Ser Val Ala Tyr Ile Thr Ser Ser Ser Ile Asn Ile Lys 
65                  70                  75                  80  


Tyr Ala Asp Ala Val Lys Gly Arg Phe Thr Val Ser Arg Asp Asn Ala 
                85                  90                  95      


Lys Asn Leu Leu Phe Leu Gln Met Asn Ile Leu Lys Ser Glu Asp Thr 
            100                 105                 110         


Ala Met Tyr Tyr Cys Ala Arg Phe Asp Trp Asp Lys Asn Tyr Trp Gly 
        115                 120                 125             


Gln Gly Thr Met Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly 
    130                 135                 140                 


Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Gln Met Thr Gln Ser Pro 
145                 150                 155                 160 


Ser Ser Leu Pro Ala Ser Leu Gly Asp Arg Val Thr Ile Asn Cys Gln 
                165                 170                 175     


Ala Ser Gln Asp Ile Ser Asn Tyr Leu Asn Trp Tyr Gln Gln Lys Pro 
            180                 185                 190         


Gly Lys Ala Pro Lys Leu Leu Ile Tyr Tyr Thr Asn Lys Leu Ala Asp 
        195                 200                 205             


Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Arg Asp Ser Ser 
    210                 215                 220                 


Phe Thr Ile Ser Ser Leu Glu Ser Glu Asp Ile Gly Ser Tyr Tyr Cys 
225                 230                 235                 240 


Gln Gln Tyr Tyr Asn Tyr Pro Trp Thr Phe Gly Pro Gly Thr Lys Leu 
                245                 250                 255     


Glu Ile Lys Gly Gly Gly Gly Ser Met Glu Val Gln Val Val Glu Ser 
            260                 265                 270         


Asp Gly Gly Leu Val Gln Pro Gly Arg Ser Leu Lys Leu Pro Cys Ala 
        275                 280                 285             


Ala Ser Gly Phe Thr Phe Ser Asp Tyr Tyr Met Ala Trp Val Arg Gln 
    290                 295                 300                 


Ala Pro Thr Lys Gly Leu Glu Trp Val Ala Ser Ile Ser Tyr Asp Gly 
305                 310                 315                 320 


Ser Ser Thr Tyr Tyr Arg Asp Ser Val Lys Gly Arg Phe Thr Ile Ser 
                325                 330                 335     


Arg Asp Asn Ala Lys Ser Thr Leu Tyr Leu Gln Met Asp Ser Leu Arg 
            340                 345                 350         


Ser Glu Asp Thr Ala Thr Tyr Tyr Cys Gly Arg His Ser Ser Tyr Phe 
        355                 360                 365             


Asp Tyr Trp Gly Gln Gly Val Met Val Thr Val Ser Ser Gly Gly Gly 
    370                 375                 380                 


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Thr Val Leu 
385                 390                 395                 400 


Thr Gln Ser Pro Ala Leu Ala Val Ser Pro Gly Glu Arg Val Thr Ile 
                405                 410                 415     


Ser Cys Arg Ala Ser Asp Ser Val Ser Thr Leu Met His Trp Tyr Gln 
            420                 425                 430         


Gln Lys Pro Gly Gln Gln Pro Lys Leu Leu Ile Tyr Leu Ala Ser His 
        435                 440                 445             


Leu Glu Ser Gly Val Pro Ala Arg Phe Ser Gly Ser Gly Ser Gly Thr 
    450                 455                 460                 


Asp Phe Thr Leu Thr Ile Asp Pro Val Glu Ala Asp Asp Thr Ala Thr 
465                 470                 475                 480 


Tyr Tyr Cys Gln Gln Ser Trp Asn Asp Pro Trp Thr Phe Gly Gly Gly 
                485                 490                 495     


Thr Lys Leu Glu Leu Lys Asn Gly Ala Val Glu His His His His His 
            500                 505                 510         


His 
    


<210>  21
<211>  1413
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  BEAT 4 MHCII-anti-CD3


<220>
<221>  CDS
<222>  (1)..(1413)

<400>  21
atg gag aca gac aca ctc ctg cta tgg gta ctg ctg ctc tgg gtt cca         48
Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro           
1               5                   10                  15                

ggt tcc act ggt gac gag gtg cag ctg gtg gag tct ggg gga ggc ttg         96
Gly Ser Thr Gly Asp Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu           
            20                  25                  30                    

gtg cag cct gga aag tcc ctg aaa ctc tcc tgt gag gcc tct gga ttc        144
Val Gln Pro Gly Lys Ser Leu Lys Leu Ser Cys Glu Ala Ser Gly Phe           
        35                  40                  45                        

acc ttc agc ggc tat ggc atg cac tgg gtc cgc cag gct cca ggg agg        192
Thr Phe Ser Gly Tyr Gly Met His Trp Val Arg Gln Ala Pro Gly Arg           
    50                  55                  60                            

ggg ctg gag tcg gtc gca tac att act agt agt agt att aat atc aaa        240
Gly Leu Glu Ser Val Ala Tyr Ile Thr Ser Ser Ser Ile Asn Ile Lys           
65                  70                  75                  80            

tat gct gac gct gtg aaa ggc cgg ttc acc gtc tcc aga gac aat gcc        288
Tyr Ala Asp Ala Val Lys Gly Arg Phe Thr Val Ser Arg Asp Asn Ala           
                85                  90                  95                

aag aac tta ctg ttt cta caa atg aac att ctc aag tct gag gac aca        336
Lys Asn Leu Leu Phe Leu Gln Met Asn Ile Leu Lys Ser Glu Asp Thr           
            100                 105                 110                   

gcc atg tac tac tgt gca aga ttc gac tgg gac aaa aat tac tgg ggc        384
Ala Met Tyr Tyr Cys Ala Arg Phe Asp Trp Asp Lys Asn Tyr Trp Gly           
        115                 120                 125                       

caa gga acc atg gtc acc gtc tcc tca ggt gga ggc ggt tca ggc gga        432
Gln Gly Thr Met Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly           
    130                 135                 140                           

ggt ggc tct ggc ggt ggc gga tcg gac atc cag atg acc cag tct cca        480
Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Gln Met Thr Gln Ser Pro           
145                 150                 155                 160           

tca tca ctg cct gcc tcc ctg gga gac aga gtc act atc aat tgt cag        528
Ser Ser Leu Pro Ala Ser Leu Gly Asp Arg Val Thr Ile Asn Cys Gln           
                165                 170                 175               

gcc agt cag gac att agc aat tat tta aac tgg tac cag cag aaa cca        576
Ala Ser Gln Asp Ile Ser Asn Tyr Leu Asn Trp Tyr Gln Gln Lys Pro           
            180                 185                 190                   

ggg aaa gct cct aag ctc ctg atc tat tat aca aat aaa ttg gca gat        624
Gly Lys Ala Pro Lys Leu Leu Ile Tyr Tyr Thr Asn Lys Leu Ala Asp           
        195                 200                 205                       

gga gtc cca tca agg ttc agt ggc agt ggt tct ggg aga gat tct tct        672
Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Arg Asp Ser Ser           
    210                 215                 220                           

ttc act atc agc agc ctg gaa tcc gaa gat att gga tct tat tac tgt        720
Phe Thr Ile Ser Ser Leu Glu Ser Glu Asp Ile Gly Ser Tyr Tyr Cys           
225                 230                 235                 240           

caa cag tat tat aac tat ccg tgg acg ttc gga cct ggc acc aag ctg        768
Gln Gln Tyr Tyr Asn Tyr Pro Trp Thr Phe Gly Pro Gly Thr Lys Leu           
                245                 250                 255               

gaa atc aaa ggt gga ggc ggt tca gag gtg cag ctt cag gag tca gga        816
Glu Ile Lys Gly Gly Gly Gly Ser Glu Val Gln Leu Gln Glu Ser Gly           
            260                 265                 270                   

cct ggc ctt gtg aaa ccc tca cag tca ctc tcc ctc acc tgt tct gtc        864
Pro Gly Leu Val Lys Pro Ser Gln Ser Leu Ser Leu Thr Cys Ser Val           
        275                 280                 285                       

act gct tac ttc atc act agt aat tac tgg gcc tgg atc cgg aag ttc        912
Thr Ala Tyr Phe Ile Thr Ser Asn Tyr Trp Ala Trp Ile Arg Lys Phe           
    290                 295                 300                           

cca gga aat aaa atg gag tgg atg gga cac ata acc tac agt ggt tac        960
Pro Gly Asn Lys Met Glu Trp Met Gly His Ile Thr Tyr Ser Gly Tyr           
305                 310                 315                 320           

act acc tac aat cca tct ctc aaa agt cga atc tcc att act aga gac       1008
Thr Thr Tyr Asn Pro Ser Leu Lys Ser Arg Ile Ser Ile Thr Arg Asp           
                325                 330                 335               

aca tcg agg aat cag ttc ttc ctc cag ttg aac tct gta act act gag       1056
Thr Ser Arg Asn Gln Phe Phe Leu Gln Leu Asn Ser Val Thr Thr Glu           
            340                 345                 350                   

gac aca gcc act tat tac tgt gca aga ggt gga ggc ggt tca ggc gga       1104
Asp Thr Ala Thr Tyr Tyr Cys Ala Arg Gly Gly Gly Gly Ser Gly Gly           
        355                 360                 365                       

ggt ggc tct ggc ggt ggc gga tcg aac att gta atg acc caa tct ccc       1152
Gly Gly Ser Gly Gly Gly Gly Ser Asn Ile Val Met Thr Gln Ser Pro           
    370                 375                 380                           

aaa tcc atg tcc atg tca gta gga gag agg gtc acc ttg acc tgc aag       1200
Lys Ser Met Ser Met Ser Val Gly Glu Arg Val Thr Leu Thr Cys Lys           
385                 390                 395                 400           

gcc agt gag aat gtg gtt act tat gtt tcc tgg tat caa cag aaa cca       1248
Ala Ser Glu Asn Val Val Thr Tyr Val Ser Trp Tyr Gln Gln Lys Pro           
                405                 410                 415               

gag cag tct cct aaa ctg ctg ata tac ggg gca tcc aac cgg tac act       1296
Glu Gln Ser Pro Lys Leu Leu Ile Tyr Gly Ala Ser Asn Arg Tyr Thr           
            420                 425                 430                   

ggg gtc ccc gat cgc ttc aca ggc agt gga tct gca aca gat ttc act       1344
Gly Val Pro Asp Arg Phe Thr Gly Ser Gly Ser Ala Thr Asp Phe Thr           
        435                 440                 445                       

ctg acc atc agc agt gtg cag gct gaa gac ctt gca gat tat cac tgt       1392
Leu Thr Ile Ser Ser Val Gln Ala Glu Asp Leu Ala Asp Tyr His Cys           
    450                 455                 460                           

gga cag ggt tac agc tat ccg                                           1413
Gly Gln Gly Tyr Ser Tyr Pro                                               
465                 470                                                   


<210>  22
<211>  471
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  22

Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 
1               5                   10                  15      


Gly Ser Thr Gly Asp Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu 
            20                  25                  30          


Val Gln Pro Gly Lys Ser Leu Lys Leu Ser Cys Glu Ala Ser Gly Phe 
        35                  40                  45              


Thr Phe Ser Gly Tyr Gly Met His Trp Val Arg Gln Ala Pro Gly Arg 
    50                  55                  60                  


Gly Leu Glu Ser Val Ala Tyr Ile Thr Ser Ser Ser Ile Asn Ile Lys 
65                  70                  75                  80  


Tyr Ala Asp Ala Val Lys Gly Arg Phe Thr Val Ser Arg Asp Asn Ala 
                85                  90                  95      


Lys Asn Leu Leu Phe Leu Gln Met Asn Ile Leu Lys Ser Glu Asp Thr 
            100                 105                 110         


Ala Met Tyr Tyr Cys Ala Arg Phe Asp Trp Asp Lys Asn Tyr Trp Gly 
        115                 120                 125             


Gln Gly Thr Met Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly 
    130                 135                 140                 


Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Gln Met Thr Gln Ser Pro 
145                 150                 155                 160 


Ser Ser Leu Pro Ala Ser Leu Gly Asp Arg Val Thr Ile Asn Cys Gln 
                165                 170                 175     


Ala Ser Gln Asp Ile Ser Asn Tyr Leu Asn Trp Tyr Gln Gln Lys Pro 
            180                 185                 190         


Gly Lys Ala Pro Lys Leu Leu Ile Tyr Tyr Thr Asn Lys Leu Ala Asp 
        195                 200                 205             


Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Arg Asp Ser Ser 
    210                 215                 220                 


Phe Thr Ile Ser Ser Leu Glu Ser Glu Asp Ile Gly Ser Tyr Tyr Cys 
225                 230                 235                 240 


Gln Gln Tyr Tyr Asn Tyr Pro Trp Thr Phe Gly Pro Gly Thr Lys Leu 
                245                 250                 255     


Glu Ile Lys Gly Gly Gly Gly Ser Glu Val Gln Leu Gln Glu Ser Gly 
            260                 265                 270         


Pro Gly Leu Val Lys Pro Ser Gln Ser Leu Ser Leu Thr Cys Ser Val 
        275                 280                 285             


Thr Ala Tyr Phe Ile Thr Ser Asn Tyr Trp Ala Trp Ile Arg Lys Phe 
    290                 295                 300                 


Pro Gly Asn Lys Met Glu Trp Met Gly His Ile Thr Tyr Ser Gly Tyr 
305                 310                 315                 320 


Thr Thr Tyr Asn Pro Ser Leu Lys Ser Arg Ile Ser Ile Thr Arg Asp 
                325                 330                 335     


Thr Ser Arg Asn Gln Phe Phe Leu Gln Leu Asn Ser Val Thr Thr Glu 
            340                 345                 350         


Asp Thr Ala Thr Tyr Tyr Cys Ala Arg Gly Gly Gly Gly Ser Gly Gly 
        355                 360                 365             


Gly Gly Ser Gly Gly Gly Gly Ser Asn Ile Val Met Thr Gln Ser Pro 
    370                 375                 380                 


Lys Ser Met Ser Met Ser Val Gly Glu Arg Val Thr Leu Thr Cys Lys 
385                 390                 395                 400 


Ala Ser Glu Asn Val Val Thr Tyr Val Ser Trp Tyr Gln Gln Lys Pro 
                405                 410                 415     


Glu Gln Ser Pro Lys Leu Leu Ile Tyr Gly Ala Ser Asn Arg Tyr Thr 
            420                 425                 430         


Gly Val Pro Asp Arg Phe Thr Gly Ser Gly Ser Ala Thr Asp Phe Thr 
        435                 440                 445             


Leu Thr Ile Ser Ser Val Gln Ala Glu Asp Leu Ala Asp Tyr His Cys 
    450                 455                 460                 


Gly Gln Gly Tyr Ser Tyr Pro 
465                 470     


<210>  23
<211>  5497
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  BEAT 1 vector

<400>  23
gaattaattc ataccagatc accgaaaact gtcctccaaa tgtgtccccc tcacactccc       60

aaattcgcgg gcttctgctc ttagaccact ctaccctatt ccccacactc accggagcca      120

aagccgcggc ccttccgttt ctttgctttt gaaagacccc acccgtaggt ggcaagctag      180

cttaagtaac gccactttgc aaggcatgga aaaatacata actgagaata ggaaagttca      240

gatcaaggtc aggaacaaag aaacagctga ataccaaaca ggatatctgt ggtaagcggt      300

tcctgccccg gctcagggcc aagaacagat gagacagctg agtgatgggc caaacaggat      360

atctgtggta agcagttcct gccccggctc ggggccaaga acagatggtc cccagatgcg      420

gtccagccct cagcagtttc tagtgaatca tcagatgttt ccagggtgcc ccaaggacct      480

gaaaatgacc ctgtacctta tttgaactaa ccaatcagtt cgcttctcgc ttctgttcgc      540

gcgcttccgc tctccgagct caataaaaga gcccacaacc cctcactcgg cgcgccagtc      600

ttccgataga ctgcgtcgcc cgggtacccg tattcccaat aaagcctctt gctgtttgca      660

tccgaatcgt ggtctcgctg ttccttggga gggtctcctc tgagtgattg actacccacg      720

acgggggtct ttcatttggg ggctcgtccg ggatttggag acccctgccc agggaccacc      780

gacccaccac cgggaggtaa gctggccagc aacctatctg tgtctgtccg attgtctagt      840

gtctatgttt gatgttatgc gcctgcgtct gtactagtta gctaactagc tctgtatctg      900

gcggacccgt ggtggaactg acgagttctg aacacccggc cgcaacccag ggagacgtcc      960

cagggacttt gggggccgtt tttgtggccc gacctgagga agggagtcga tgtggaatcc     1020

gaccccgtca ggatatgtgg ttctggtagg agacgagaac ctaaaacagt tcccgcctcc     1080

gtctgaattt ttgctttcgg tttggaaccg aagccgcgcg tcttgtctgc tgcagcatcg     1140

ttctgtgttg tctctgtctg actgtgtttc tgtatttgtc tgaaaattag ggccagactg     1200

ttaccactcc cttaagtttg accttaggtc actggaaaga tgtcgagcgg atcgctcaca     1260

accagtcggt agatgtcaag aagagacgtt gggttacctt ctgctctgca gaatggccaa     1320

cctttaacgt cggatggccg cgagacggca cctttaaccg agacctcatc acccaggtta     1380

agatcaaggt cttttcacct ggcccgcatg gacacccaga ccaggtcccc tacatcgtga     1440

cctgggaagc cttggctttt gacccccctc cctgggtcaa gccctttgta caccctaagc     1500

ctccgcctcc tcttcctcca tccgccccgt ctctccccct tgaacctcct cgttcgaccc     1560

cgcctcgatc ctccctttat ccagccctca ctccttctct aggcgccgga attccggccg     1620

tgacaagagt tactaacagc ccctctctcc aagctcactt acaggctctc tacttagtcc     1680

agcacgaagt ctggagacct ctggcggcag cctaccaaga acaactggac cgaccggtgg     1740

tacctcaccc ttaccgagtc ggcgacacag tgtgggtccg ccgacaccag actaagaacc     1800

tagaacctcg ctggaaagga ccttacacag tcctgcagac cacccccacc gccctcaaag     1860

tagacggcat cgcagcttgg atacacgccg cccacgtgaa ggctgccgac cccgggggtg     1920

gaccatctct agactgacgc ggccgcccac cgaggtgcac ctggtggagt ctgggggaga     1980

cttagtgaag cctggagggt ccctgaaact ctcctgtgca gcctctggat tcactttcag     2040

tcactatggc atgtcttggg ttcgccagac tccagacaag aggctggagt gggtcgcaac     2100

cattggtagt cgtggtactt acacccacta tccagacagt gtgaagggac gattcaccat     2160

ctccagagac aatgacaaga acgccctgta cctgcaaatg aacagtctga agtctgaaga     2220

cacagccatg tattactgtg caagaagaag tgaattttat tactacggta atacctacta     2280

ttactctgct atggactact ggggtcaagg agcctcagtc accgtctcct caggtggagg     2340

cggttcaggc ggaggtggct ctggcggtgg cggatcggac attgtgctga cccaatctcc     2400

agcttctttg gctgtatctc taggacagag ggccaccatc tcctgcagag ccagcgaaag     2460

tgttgataat tatggcttta gttttatgaa ctggttccaa cagaaaccag gacagccacc     2520

caaactcctc atctatgcta tatccaaccg aggatccggg gtccctgcca ggtttagtgg     2580

cagtgggtct gggacagact tcagcctcaa catccatcct gtagaggagg atgatcctgc     2640

aatgtatttc tgtcagcaaa ctaaggaggt tccgtggacg ttcggtggag gcaccaagct     2700

ggaaatcaaa ggtggaggcg gttcaatgga ggtgcaggtg gtggagtctg atggaggctt     2760

agtgcagcct ggaaggtccc taaaactccc ctgtgcagcc tcaggattca ctttcagtga     2820

ctattacatg gcctgggtcc gccaggctcc aacgaagggg ctggagtggg tcgcaagcat     2880

tagttatgat ggtagtagca cttactatcg agactccgtg aagggccgat tcactatctc     2940

cagagataat gcaaaaagca ccctatacct gcaaatggac agtctgaggt ctgaggacac     3000

ggccacttat tactgcggaa gacacagtag ctactttgat tactggggcc aaggagtcat     3060

ggtcacagtc tcctcaggtg gaggcggttc aggcggaggt ggctctggcg gtggcggatc     3120

ggacactgta ctgacccagt ctcctgcttt ggctgtgtct ccaggagaga gggttaccat     3180

ctcctgtagg gccagtgaca gtgtcagtac acttatgcac tggtaccaac agaaaccagg     3240

acagcaaccc aaactcctca tctatctagc atcacaccta gaatctgggg tccctgccag     3300

gttcagtggc agtgggtctg ggacagactt caccctcacc attgatcctg tggaggctga     3360

tgacactgca acctattact gtcagcagag ttggaatgat ccgtggacgt tcggtggagg     3420

caccaagctg gaattgaaaa atggggccgt cgagcaccac caccaccacc actgagtcga     3480

ggatcaattc cgcccctctc cctccccccc ccctaacgtt actggccgaa gccgcttgga     3540

ataaggccgg tgtgcgtttg tctatatgtt attttccacc atattgccgt cttttggcaa     3600

tgtgagggcc cggaaacctg gccctgtctt cttgacgagc attcctaggg gtctttcccc     3660

tctcgccaaa ggaatgcaag gtctgttgaa tgtcgtgaag gaagcagttc ctctggaagc     3720

ttcttgaaga caaacaacgt ctgtagcgac cctttgcagg cagcggaacc ccccacctgg     3780

cgacaggtgc ctctgcggcc aaaagccacg tgtataagat acacctgcaa aggcggcaca     3840

accccagtgc cacgttgtga gttggatagt tgtggaaaga gtcaaatggc tctcctcaag     3900

cgtattcaac aaggggctga aggatgccca gaaggtaccc cattgtatgg gatctgatct     3960

ggggcctcgg tgcacatgct ttacatgtgt ttagtcgagg ttaaaaaacg tctaggcccc     4020

ccgaaccacg gggacgtggt tttcctttga aaaacacgat aataccatga ttgaacaaga     4080

tggattgcac gcaggttctc cggccgcttg ggtggagagg ctattcggct atgactgggc     4140

acaacagaca atcggctgct ctgatgccgc cgtgttccgg ctgtcagcgc aggggcgccc     4200

ggttcttttt gtcaagaccg acctgtccgg tgccctgaat gaactgcagg acgaggcagc     4260

gcggctatcg tggctggcca cgacgggcgt tccttgcgca gctgtgctcg acgttgtcac     4320

tgaagcggga agggactggc tgctattggg cgaagtgccg gggcaggatc tcctgtcatc     4380

tcaccttgct cctgccgaga aagtatccat catggctgat gcaatgcggc ggctgcatac     4440

gcttgatccg gctacctgcc cattcgacca ccaagcgaaa catcgcatcg agcgagcacg     4500

tactcggatg gaagccggtc ttgtcgatca ggatgatctg gacgaagagc atcaggggct     4560

cgcgccagcc gaactgttcg ccaggctcaa ggcgcgcatg cccgacggcg aggatctcgt     4620

cgtgacccat ggcgatgcct gcttgccgaa tatcatggtg gaaaatggcc gcttttctgg     4680

attcatcgac tgtggccggc tgggtgtggc ggaccgctat caggacatag cgttggctac     4740

ccgtgatatt gctgaagagc ttggcggcga atgggctgac cgcttcctcg tgctttacgg     4800

tatcgccgct cccgattcgc agcgcatcgc cttctatcgc cttcttgacg agttcttctg     4860

agcgggactc tggggatccg ataaaataaa agattttatt tagtctccag aaaaaggggg     4920

gaatgaaaga ccccacctgt aggtttggca agctagctta agtaacgcca ttttgcaagg     4980

catggaaaaa tacataactg agaatagaga agttcagatc aaggtcagga acagatggaa     5040

cagctgaata tgggccaaac aggatatctg tggtaagcag ttcctgcccc ggctcagggc     5100

caagaacaga tggaacagct gaatatgggc caaacaggat atctgtggta agcagttcct     5160

gccccggctc agggccaaga acagatggtc cccagatgcg gtccagccct cagcagtttc     5220

tagagaacca tcagatgttt ccagggtgcc ccaaggacct gaaatgaccc tgtgccttat     5280

ttgaactaac caatcagttc gcttctcgct tctgttcgcg cgcttctgct ccccgagctc     5340

aataaaagag cccacaaccc ctcactcggg gcgccagtcc tccgattgac tgagtcgccc     5400

gggtacccgt gtatccaata aaccctcttg cagttgcatc cgacttgtgg tctcgctgtt     5460

ccttgggagg gtctcctctg agtgattgac tacccgt                              5497


<210>  24
<211>  5368
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  BEAT 2 vector

<400>  24
gaattaattc ataccagatc accgaaaact gtcctccaaa tgtgtccccc tcacactccc       60

aaattcgcgg gcttctgctc ttagaccact ctaccctatt ccccacactc accggagcca      120

aagccgcggc ccttccgttt ctttgctttt gaaagacccc acccgtaggt ggcaagctag      180

cttaagtaac gccactttgc aaggcatgga aaaatacata actgagaata ggaaagttca      240

gatcaaggtc aggaacaaag aaacagctga ataccaaaca ggatatctgt ggtaagcggt      300

tcctgccccg gctcagggcc aagaacagat gagacagctg agtgatgggc caaacaggat      360

atctgtggta agcagttcct gccccggctc ggggccaaga acagatggtc cccagatgcg      420

gtccagccct cagcagtttc tagtgaatca tcagatgttt ccagggtgcc ccaaggacct      480

gaaaatgacc ctgtacctta tttgaactaa ccaatcagtt cgcttctcgc ttctgttcgc      540

gcgcttccgc tctccgagct caataaaaga gcccacaacc cctcactcgg cgcgccagtc      600

ttccgataga ctgcgtcgcc cgggtacccg tattcccaat aaagcctctt gctgtttgca      660

tccgaatcgt ggtctcgctg ttccttggga gggtctcctc tgagtgattg actacccacg      720

acgggggtct ttcatttggg ggctcgtccg ggatttggag acccctgccc agggaccacc      780

gacccaccac cgggaggtaa gctggccagc aacctatctg tgtctgtccg attgtctagt      840

gtctatgttt gatgttatgc gcctgcgtct gtactagtta gctaactagc tctgtatctg      900

gcggacccgt ggtggaactg acgagttctg aacacccggc cgcaacccag ggagacgtcc      960

cagggacttt gggggccgtt tttgtggccc gacctgagga agggagtcga tgtggaatcc     1020

gaccccgtca ggatatgtgg ttctggtagg agacgagaac ctaaaacagt tcccgcctcc     1080

gtctgaattt ttgctttcgg tttggaaccg aagccgcgcg tcttgtctgc tgcagcatcg     1140

ttctgtgttg tctctgtctg actgtgtttc tgtatttgtc tgaaaattag ggccagactg     1200

ttaccactcc cttaagtttg accttaggtc actggaaaga tgtcgagcgg atcgctcaca     1260

accagtcggt agatgtcaag aagagacgtt gggttacctt ctgctctgca gaatggccaa     1320

cctttaacgt cggatggccg cgagacggca cctttaaccg agacctcatc acccaggtta     1380

agatcaaggt cttttcacct ggcccgcatg gacacccaga ccaggtcccc tacatcgtga     1440

cctgggaagc cttggctttt gacccccctc cctgggtcaa gccctttgta caccctaagc     1500

ctccgcctcc tcttcctcca tccgccccgt ctctccccct tgaacctcct cgttcgaccc     1560

cgcctcgatc ctccctttat ccagccctca ctccttctct aggcgccgga attccggccg     1620

tgacaagagt tactaacagc ccctctctcc aagctcactt acaggctctc tacttagtcc     1680

agcacgaagt ctggagacct ctggcggcag cctaccaaga acaactggac cgaccggtgg     1740

tacctcaccc ttaccgagtc ggcgacacag tgtgggtccg ccgacaccag actaagaacc     1800

tagaacctcg ctggaaagga ccttacacag tcctgcagac cacccccacc gccctcaaag     1860

tagacggcat cgcagcttgg atacacgccg cccacgtgaa ggctgccgac cccgggggtg     1920

gaccatctct agactgacgc ggccgcccac cgaggtgcac ctggtggagt ctgggggaga     1980

cttagtgaag cctggagggt ccctgaaact ctcctgtgca gcctctggat tcactttcag     2040

tcactatggc atgtcttggg ttcgccagac tccagacaag aggctggagt gggtcgcaac     2100

cattggtagt cgtggtactt acacccacta tccagacagt gtgaagggac gattcaccat     2160

ctccagagac aatgacaaga acgccctgta cctgcaaatg aacagtctga agtctgaaga     2220

cacagccatg tattactgtg caagaagaag tgaattttat tactacggta atacctacta     2280

ttactctgct atggactact ggggtcaagg agcctcagtc accgtctcct caggtggagg     2340

cggttcaggc ggaggtggct ctggcggtgg cggatcggac attgtgctga cccaatctcc     2400

agcttctttg gctgtatctc taggacagag ggccaccatc tcctgcagag ccagcgaaag     2460

tgttgataat tatggcttta gttttatgaa ctggttccaa cagaaaccag gacagccacc     2520

caaactcctc atctatgcta tatccaaccg aggatccggg gtccctgcca ggtttagtgg     2580

cagtgggtct gggacagact tcagcctcaa catccatcct gtagaggagg atgatcctgc     2640

aatgtatttc tgtcagcaaa ctaaggaggt tccgtggacg ttcggtggag gcaccaagct     2700

ggaaatcaaa ggtggaggcg gttcagaggt gcagcttcag gagtcaggac ctggccttgt     2760

gaaaccctca cagtcactct ccctcacctg ttctgtcact gcttacttca tcactagtaa     2820

ttactgggcc tggatccgga agttcccagg aaataaaatg gagtggatgg gacacataac     2880

ctacagtggt tacactacct acaatccatc tctcaaaagt cgaatctcca ttactagaga     2940

cacatcgagg aatcagttct tcctccagtt gaactctgta actactgagg acacagccac     3000

ttattactgt gcaagaggtg gaggcggttc aggcggaggt ggctctggcg gtggcggatc     3060

gaacattgta atgacccaat ctcccaaatc catgtccatg tcagtaggag agagggtcac     3120

cttgacctgc aaggccagtg agaatgtggt tacttatgtt tcctggtatc aacagaaacc     3180

agagcagtct cctaaactgc tgatatacgg ggcatccaac cggtacactg gggtccccga     3240

tcgcttcaca ggcagtggat ctgcaacaga tttcactctg accatcagca gtgtgcaggc     3300

tgaagacctt gcagattatc actgtggaca gggttacagc tatccggtcg aggatcaatt     3360

ccgcccctct ccctcccccc cccctaacgt tactggccga agccgcttgg aataaggccg     3420

gtgtgcgttt gtctatatgt tattttccac catattgccg tcttttggca atgtgagggc     3480

ccggaaacct ggccctgtct tcttgacgag cattcctagg ggtctttccc ctctcgccaa     3540

aggaatgcaa ggtctgttga atgtcgtgaa ggaagcagtt cctctggaag cttcttgaag     3600

acaaacaacg tctgtagcga ccctttgcag gcagcggaac cccccacctg gcgacaggtg     3660

cctctgcggc caaaagccac gtgtataaga tacacctgca aaggcggcac aaccccagtg     3720

ccacgttgtg agttggatag ttgtggaaag agtcaaatgg ctctcctcaa gcgtattcaa     3780

caaggggctg aaggatgccc agaaggtacc ccattgtatg ggatctgatc tggggcctcg     3840

gtgcacatgc tttacatgtg tttagtcgag gttaaaaaac gtctaggccc cccgaaccac     3900

ggggacgtgg ttttcctttg aaaaacacga taataccatg attgaacaag atggattgca     3960

cgcaggttct ccggccgctt gggtggagag gctattcggc tatgactggg cacaacagac     4020

aatcggctgc tctgatgccg ccgtgttccg gctgtcagcg caggggcgcc cggttctttt     4080

tgtcaagacc gacctgtccg gtgccctgaa tgaactgcag gacgaggcag cgcggctatc     4140

gtggctggcc acgacgggcg ttccttgcgc agctgtgctc gacgttgtca ctgaagcggg     4200

aagggactgg ctgctattgg gcgaagtgcc ggggcaggat ctcctgtcat ctcaccttgc     4260

tcctgccgag aaagtatcca tcatggctga tgcaatgcgg cggctgcata cgcttgatcc     4320

ggctacctgc ccattcgacc accaagcgaa acatcgcatc gagcgagcac gtactcggat     4380

ggaagccggt cttgtcgatc aggatgatct ggacgaagag catcaggggc tcgcgccagc     4440

cgaactgttc gccaggctca aggcgcgcat gcccgacggc gaggatctcg tcgtgaccca     4500

tggcgatgcc tgcttgccga atatcatggt ggaaaatggc cgcttttctg gattcatcga     4560

ctgtggccgg ctgggtgtgg cggaccgcta tcaggacata gcgttggcta cccgtgatat     4620

tgctgaagag cttggcggcg aatgggctga ccgcttcctc gtgctttacg gtatcgccgc     4680

tcccgattcg cagcgcatcg ccttctatcg ccttcttgac gagttcttct gagcgggact     4740

ctggggatcc gataaaataa aagattttat ttagtctcca gaaaaagggg ggaatgaaag     4800

accccacctg taggtttggc aagctagctt aagtaacgcc attttgcaag gcatggaaaa     4860

atacataact gagaatagag aagttcagat caaggtcagg aacagatgga acagctgaat     4920

atgggccaaa caggatatct gtggtaagca gttcctgccc cggctcaggg ccaagaacag     4980

atggaacagc tgaatatggg ccaaacagga tatctgtggt aagcagttcc tgccccggct     5040

cagggccaag aacagatggt ccccagatgc ggtccagccc tcagcagttt ctagagaacc     5100

atcagatgtt tccagggtgc cccaaggacc tgaaatgacc ctgtgcctta tttgaactaa     5160

ccaatcagtt cgcttctcgc ttctgttcgc gcgcttctgc tccccgagct caataaaaga     5220

gcccacaacc cctcactcgg ggcgccagtc ctccgattga ctgagtcgcc cgggtacccg     5280

tgtatccaat aaaccctctt gcagttgcat ccgacttgtg gtctcgctgt tccttgggag     5340

ggtctcctct gagtgattga ctacccgt                                        5368


<210>  25
<211>  5515
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  BEAT 3 vector

<400>  25
gaattaattc ataccagatc accgaaaact gtcctccaaa tgtgtccccc tcacactccc       60

aaattcgcgg gcttctgctc ttagaccact ctaccctatt ccccacactc accggagcca      120

aagccgcggc ccttccgttt ctttgctttt gaaagacccc acccgtaggt ggcaagctag      180

cttaagtaac gccactttgc aaggcatgga aaaatacata actgagaata ggaaagttca      240

gatcaaggtc aggaacaaag aaacagctga ataccaaaca ggatatctgt ggtaagcggt      300

tcctgccccg gctcagggcc aagaacagat gagacagctg agtgatgggc caaacaggat      360

atctgtggta agcagttcct gccccggctc ggggccaaga acagatggtc cccagatgcg      420

gtccagccct cagcagtttc tagtgaatca tcagatgttt ccagggtgcc ccaaggacct      480

gaaaatgacc ctgtacctta tttgaactaa ccaatcagtt cgcttctcgc ttctgttcgc      540

gcgcttccgc tctccgagct caataaaaga gcccacaacc cctcactcgg cgcgccagtc      600

ttccgataga ctgcgtcgcc cgggtacccg tattcccaat aaagcctctt gctgtttgca      660

tccgaatcgt ggtctcgctg ttccttggga gggtctcctc tgagtgattg actacccacg      720

acgggggtct ttcatttggg ggctcgtccg ggatttggag acccctgccc agggaccacc      780

gacccaccac cgggaggtaa gctggccagc aacctatctg tgtctgtccg attgtctagt      840

gtctatgttt gatgttatgc gcctgcgtct gtactagtta gctaactagc tctgtatctg      900

gcggacccgt ggtggaactg acgagttctg aacacccggc cgcaacccag ggagacgtcc      960

cagggacttt gggggccgtt tttgtggccc gacctgagga agggagtcga tgtggaatcc     1020

gaccccgtca ggatatgtgg ttctggtagg agacgagaac ctaaaacagt tcccgcctcc     1080

gtctgaattt ttgctttcgg tttggaaccg aagccgcgcg tcttgtctgc tgcagcatcg     1140

ttctgtgttg tctctgtctg actgtgtttc tgtatttgtc tgaaaattag ggccagactg     1200

ttaccactcc cttaagtttg accttaggtc actggaaaga tgtcgagcgg atcgctcaca     1260

accagtcggt agatgtcaag aagagacgtt gggttacctt ctgctctgca gaatggccaa     1320

cctttaacgt cggatggccg cgagacggca cctttaaccg agacctcatc acccaggtta     1380

agatcaaggt cttttcacct ggcccgcatg gacacccaga ccaggtcccc tacatcgtga     1440

cctgggaagc cttggctttt gacccccctc cctgggtcaa gccctttgta caccctaagc     1500

ctccgcctcc tcttcctcca tccgccccgt ctctccccct tgaacctcct cgttcgaccc     1560

cgcctcgatc ctccctttat ccagccctca ctccttctct aggcgccgga attccggccg     1620

tgacaagagt tactaacagc ccctctctcc aagctcactt acaggctctc tacttagtcc     1680

agcacgaagt ctggagacct ctggcggcag cctaccaaga acaactggac cgaccggtgg     1740

tacctcaccc ttaccgagtc ggcgacacag tgtgggtccg ccgacaccag actaagaacc     1800

tagaacctcg ctggaaagga ccttacacag tcctgcagac cacccccacc gccctcaaag     1860

tagacggcat cgcagcttgg atacacgccg cccacgtgaa ggctgccgac cccgggggtg     1920

gaccatctct agactgacgc ggccgcccac catggagaca gacacactcc tgctatgggt     1980

actgctgctc tgggttccag gttccactgg tgacgaggtg cagctggtgg agtctggggg     2040

aggcttggtg cagcctggaa agtccctgaa actctcctgt gaggcctctg gattcacctt     2100

cagcggctat ggcatgcact gggtccgcca ggctccaggg agggggctgg agtcggtcgc     2160

atacattact agtagtagta ttaatatcaa atatgctgac gctgtgaaag gccggttcac     2220

cgtctccaga gacaatgcca agaacttact gtttctacaa atgaacattc tcaagtctga     2280

ggacacagcc atgtactact gtgcaagatt cgactgggac aaaaattact ggggccaagg     2340

aaccatggtc accgtctcct caggtggagg cggttcaggc ggaggtggct ctggcggtgg     2400

cggatcggac atccagatga cccagtctcc atcatcactg cctgcctccc tgggagacag     2460

agtcactatc aattgtcagg ccagtcagga cattagcaat tatttaaact ggtaccagca     2520

gaaaccaggg aaagctccta agctcctgat ctattataca aataaattgg cagatggagt     2580

cccatcaagg ttcagtggca gtggttctgg gagagattct tctttcacta tcagcagcct     2640

ggaatccgaa gatattggat cttattactg tcaacagtat tataactatc cgtggacgtt     2700

cggacctggc accaagctgg aaatcaaagg tggaggcggt tcaatggagg tgcaggtggt     2760

ggagtctgat ggaggcttag tgcagcctgg aaggtcccta aaactcccct gtgcagcctc     2820

aggattcact ttcagtgact attacatggc ctgggtccgc caggctccaa cgaaggggct     2880

ggagtgggtc gcaagcatta gttatgatgg tagtagcact tactatcgag actccgtgaa     2940

gggccgattc actatctcca gagataatgc aaaaagcacc ctatacctgc aaatggacag     3000

tctgaggtct gaggacacgg ccacttatta ctgcggaaga cacagtagct actttgatta     3060

ctggggccaa ggagtcatgg tcacagtctc ctcaggtgga ggcggttcag gcggaggtgg     3120

ctctggcggt ggcggatcgg acactgtact gacccagtct cctgctttgg ctgtgtctcc     3180

aggagagagg gttaccatct cctgtagggc cagtgacagt gtcagtacac ttatgcactg     3240

gtaccaacag aaaccaggac agcaacccaa actcctcatc tatctagcat cacacctaga     3300

atctggggtc cctgccaggt tcagtggcag tgggtctggg acagacttca ccctcaccat     3360

tgatcctgtg gaggctgatg acactgcaac ctattactgt cagcagagtt ggaatgatcc     3420

gtggacgttc ggtggaggca ccaagctgga attgaaaaat ggggccgtcg agcaccacca     3480

ccaccaccac tgagtcgagg atcaattccg cccctctccc tccccccccc ctaacgttac     3540

tggccgaagc cgcttggaat aaggccggtg tgcgtttgtc tatatgttat tttccaccat     3600

attgccgtct tttggcaatg tgagggcccg gaaacctggc cctgtcttct tgacgagcat     3660

tcctaggggt ctttcccctc tcgccaaagg aatgcaaggt ctgttgaatg tcgtgaagga     3720

agcagttcct ctggaagctt cttgaagaca aacaacgtct gtagcgaccc tttgcaggca     3780

gcggaacccc ccacctggcg acaggtgcct ctgcggccaa aagccacgtg tataagatac     3840

acctgcaaag gcggcacaac cccagtgcca cgttgtgagt tggatagttg tggaaagagt     3900

caaatggctc tcctcaagcg tattcaacaa ggggctgaag gatgcccaga aggtacccca     3960

ttgtatggga tctgatctgg ggcctcggtg cacatgcttt acatgtgttt agtcgaggtt     4020

aaaaaacgtc taggcccccc gaaccacggg gacgtggttt tcctttgaaa aacacgataa     4080

taccatgatt gaacaagatg gattgcacgc aggttctccg gccgcttggg tggagaggct     4140

attcggctat gactgggcac aacagacaat cggctgctct gatgccgccg tgttccggct     4200

gtcagcgcag gggcgcccgg ttctttttgt caagaccgac ctgtccggtg ccctgaatga     4260

actgcaggac gaggcagcgc ggctatcgtg gctggccacg acgggcgttc cttgcgcagc     4320

tgtgctcgac gttgtcactg aagcgggaag ggactggctg ctattgggcg aagtgccggg     4380

gcaggatctc ctgtcatctc accttgctcc tgccgagaaa gtatccatca tggctgatgc     4440

aatgcggcgg ctgcatacgc ttgatccggc tacctgccca ttcgaccacc aagcgaaaca     4500

tcgcatcgag cgagcacgta ctcggatgga agccggtctt gtcgatcagg atgatctgga     4560

cgaagagcat caggggctcg cgccagccga actgttcgcc aggctcaagg cgcgcatgcc     4620

cgacggcgag gatctcgtcg tgacccatgg cgatgcctgc ttgccgaata tcatggtgga     4680

aaatggccgc ttttctggat tcatcgactg tggccggctg ggtgtggcgg accgctatca     4740

ggacatagcg ttggctaccc gtgatattgc tgaagagctt ggcggcgaat gggctgaccg     4800

cttcctcgtg ctttacggta tcgccgctcc cgattcgcag cgcatcgcct tctatcgcct     4860

tcttgacgag ttcttctgag cgggactctg gggatccgat aaaataaaag attttattta     4920

gtctccagaa aaagggggga atgaaagacc ccacctgtag gtttggcaag ctagcttaag     4980

taacgccatt ttgcaaggca tggaaaaata cataactgag aatagagaag ttcagatcaa     5040

ggtcaggaac agatggaaca gctgaatatg ggccaaacag gatatctgtg gtaagcagtt     5100

cctgccccgg ctcagggcca agaacagatg gaacagctga atatgggcca aacaggatat     5160

ctgtggtaag cagttcctgc cccggctcag ggccaagaac agatggtccc cagatgcggt     5220

ccagccctca gcagtttcta gagaaccatc agatgtttcc agggtgcccc aaggacctga     5280

aatgaccctg tgccttattt gaactaacca atcagttcgc ttctcgcttc tgttcgcgcg     5340

cttctgctcc ccgagctcaa taaaagagcc cacaacccct cactcggggc gccagtcctc     5400

cgattgactg agtcgcccgg gtacccgtgt atccaataaa ccctcttgca gttgcatccg     5460

acttgtggtc tcgctgttcc ttgggagggt ctcctctgag tgattgacta cccgt          5515


<210>  26
<211>  5386
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  BEAT 4 vector

<400>  26
gaattaattc ataccagatc accgaaaact gtcctccaaa tgtgtccccc tcacactccc       60

aaattcgcgg gcttctgctc ttagaccact ctaccctatt ccccacactc accggagcca      120

aagccgcggc ccttccgttt ctttgctttt gaaagacccc acccgtaggt ggcaagctag      180

cttaagtaac gccactttgc aaggcatgga aaaatacata actgagaata ggaaagttca      240

gatcaaggtc aggaacaaag aaacagctga ataccaaaca ggatatctgt ggtaagcggt      300

tcctgccccg gctcagggcc aagaacagat gagacagctg agtgatgggc caaacaggat      360

atctgtggta agcagttcct gccccggctc ggggccaaga acagatggtc cccagatgcg      420

gtccagccct cagcagtttc tagtgaatca tcagatgttt ccagggtgcc ccaaggacct      480

gaaaatgacc ctgtacctta tttgaactaa ccaatcagtt cgcttctcgc ttctgttcgc      540

gcgcttccgc tctccgagct caataaaaga gcccacaacc cctcactcgg cgcgccagtc      600

ttccgataga ctgcgtcgcc cgggtacccg tattcccaat aaagcctctt gctgtttgca      660

tccgaatcgt ggtctcgctg ttccttggga gggtctcctc tgagtgattg actacccacg      720

acgggggtct ttcatttggg ggctcgtccg ggatttggag acccctgccc agggaccacc      780

gacccaccac cgggaggtaa gctggccagc aacctatctg tgtctgtccg attgtctagt      840

gtctatgttt gatgttatgc gcctgcgtct gtactagtta gctaactagc tctgtatctg      900

gcggacccgt ggtggaactg acgagttctg aacacccggc cgcaacccag ggagacgtcc      960

cagggacttt gggggccgtt tttgtggccc gacctgagga agggagtcga tgtggaatcc     1020

gaccccgtca ggatatgtgg ttctggtagg agacgagaac ctaaaacagt tcccgcctcc     1080

gtctgaattt ttgctttcgg tttggaaccg aagccgcgcg tcttgtctgc tgcagcatcg     1140

ttctgtgttg tctctgtctg actgtgtttc tgtatttgtc tgaaaattag ggccagactg     1200

ttaccactcc cttaagtttg accttaggtc actggaaaga tgtcgagcgg atcgctcaca     1260

accagtcggt agatgtcaag aagagacgtt gggttacctt ctgctctgca gaatggccaa     1320

cctttaacgt cggatggccg cgagacggca cctttaaccg agacctcatc acccaggtta     1380

agatcaaggt cttttcacct ggcccgcatg gacacccaga ccaggtcccc tacatcgtga     1440

cctgggaagc cttggctttt gacccccctc cctgggtcaa gccctttgta caccctaagc     1500

ctccgcctcc tcttcctcca tccgccccgt ctctccccct tgaacctcct cgttcgaccc     1560

cgcctcgatc ctccctttat ccagccctca ctccttctct aggcgccgga attccggccg     1620

tgacaagagt tactaacagc ccctctctcc aagctcactt acaggctctc tacttagtcc     1680

agcacgaagt ctggagacct ctggcggcag cctaccaaga acaactggac cgaccggtgg     1740

tacctcaccc ttaccgagtc ggcgacacag tgtgggtccg ccgacaccag actaagaacc     1800

tagaacctcg ctggaaagga ccttacacag tcctgcagac cacccccacc gccctcaaag     1860

tagacggcat cgcagcttgg atacacgccg cccacgtgaa ggctgccgac cccgggggtg     1920

gaccatctct agactgacgc ggccgcccac catggagaca gacacactcc tgctatgggt     1980

actgctgctc tgggttccag gttccactgg tgacgaggtg cagctggtgg agtctggggg     2040

aggcttggtg cagcctggaa agtccctgaa actctcctgt gaggcctctg gattcacctt     2100

cagcggctat ggcatgcact gggtccgcca ggctccaggg agggggctgg agtcggtcgc     2160

atacattact agtagtagta ttaatatcaa atatgctgac gctgtgaaag gccggttcac     2220

cgtctccaga gacaatgcca agaacttact gtttctacaa atgaacattc tcaagtctga     2280

ggacacagcc atgtactact gtgcaagatt cgactgggac aaaaattact ggggccaagg     2340

aaccatggtc accgtctcct caggtggagg cggttcaggc ggaggtggct ctggcggtgg     2400

cggatcggac atccagatga cccagtctcc atcatcactg cctgcctccc tgggagacag     2460

agtcactatc aattgtcagg ccagtcagga cattagcaat tatttaaact ggtaccagca     2520

gaaaccaggg aaagctccta agctcctgat ctattataca aataaattgg cagatggagt     2580

cccatcaagg ttcagtggca gtggttctgg gagagattct tctttcacta tcagcagcct     2640

ggaatccgaa gatattggat cttattactg tcaacagtat tataactatc cgtggacgtt     2700

cggacctggc accaagctgg aaatcaaagg tggaggcggt tcagaggtgc agcttcagga     2760

gtcaggacct ggccttgtga aaccctcaca gtcactctcc ctcacctgtt ctgtcactgc     2820

ttacttcatc actagtaatt actgggcctg gatccggaag ttcccaggaa ataaaatgga     2880

gtggatggga cacataacct acagtggtta cactacctac aatccatctc tcaaaagtcg     2940

aatctccatt actagagaca catcgaggaa tcagttcttc ctccagttga actctgtaac     3000

tactgaggac acagccactt attactgtgc aagaggtgga ggcggttcag gcggaggtgg     3060

ctctggcggt ggcggatcga acattgtaat gacccaatct cccaaatcca tgtccatgtc     3120

agtaggagag agggtcacct tgacctgcaa ggccagtgag aatgtggtta cttatgtttc     3180

ctggtatcaa cagaaaccag agcagtctcc taaactgctg atatacgggg catccaaccg     3240

gtacactggg gtccccgatc gcttcacagg cagtggatct gcaacagatt tcactctgac     3300

catcagcagt gtgcaggctg aagaccttgc agattatcac tgtggacagg gttacagcta     3360

tccggtcgag gatcaattcc gcccctctcc ctcccccccc cctaacgtta ctggccgaag     3420

ccgcttggaa taaggccggt gtgcgtttgt ctatatgtta ttttccacca tattgccgtc     3480

ttttggcaat gtgagggccc ggaaacctgg ccctgtcttc ttgacgagca ttcctagggg     3540

tctttcccct ctcgccaaag gaatgcaagg tctgttgaat gtcgtgaagg aagcagttcc     3600

tctggaagct tcttgaagac aaacaacgtc tgtagcgacc ctttgcaggc agcggaaccc     3660

cccacctggc gacaggtgcc tctgcggcca aaagccacgt gtataagata cacctgcaaa     3720

ggcggcacaa ccccagtgcc acgttgtgag ttggatagtt gtggaaagag tcaaatggct     3780

ctcctcaagc gtattcaaca aggggctgaa ggatgcccag aaggtacccc attgtatggg     3840

atctgatctg gggcctcggt gcacatgctt tacatgtgtt tagtcgaggt taaaaaacgt     3900

ctaggccccc cgaaccacgg ggacgtggtt ttcctttgaa aaacacgata ataccatgat     3960

tgaacaagat ggattgcacg caggttctcc ggccgcttgg gtggagaggc tattcggcta     4020

tgactgggca caacagacaa tcggctgctc tgatgccgcc gtgttccggc tgtcagcgca     4080

ggggcgcccg gttctttttg tcaagaccga cctgtccggt gccctgaatg aactgcagga     4140

cgaggcagcg cggctatcgt ggctggccac gacgggcgtt ccttgcgcag ctgtgctcga     4200

cgttgtcact gaagcgggaa gggactggct gctattgggc gaagtgccgg ggcaggatct     4260

cctgtcatct caccttgctc ctgccgagaa agtatccatc atggctgatg caatgcggcg     4320

gctgcatacg cttgatccgg ctacctgccc attcgaccac caagcgaaac atcgcatcga     4380

gcgagcacgt actcggatgg aagccggtct tgtcgatcag gatgatctgg acgaagagca     4440

tcaggggctc gcgccagccg aactgttcgc caggctcaag gcgcgcatgc ccgacggcga     4500

ggatctcgtc gtgacccatg gcgatgcctg cttgccgaat atcatggtgg aaaatggccg     4560

cttttctgga ttcatcgact gtggccggct gggtgtggcg gaccgctatc aggacatagc     4620

gttggctacc cgtgatattg ctgaagagct tggcggcgaa tgggctgacc gcttcctcgt     4680

gctttacggt atcgccgctc ccgattcgca gcgcatcgcc ttctatcgcc ttcttgacga     4740

gttcttctga gcgggactct ggggatccga taaaataaaa gattttattt agtctccaga     4800

aaaagggggg aatgaaagac cccacctgta ggtttggcaa gctagcttaa gtaacgccat     4860

tttgcaaggc atggaaaaat acataactga gaatagagaa gttcagatca aggtcaggaa     4920

cagatggaac agctgaatat gggccaaaca ggatatctgt ggtaagcagt tcctgccccg     4980

gctcagggcc aagaacagat ggaacagctg aatatgggcc aaacaggata tctgtggtaa     5040

gcagttcctg ccccggctca gggccaagaa cagatggtcc ccagatgcgg tccagccctc     5100

agcagtttct agagaaccat cagatgtttc cagggtgccc caaggacctg aaatgaccct     5160

gtgccttatt tgaactaacc aatcagttcg cttctcgctt ctgttcgcgc gcttctgctc     5220

cccgagctca ataaaagagc ccacaacccc tcactcgggg cgccagtcct ccgattgact     5280

gagtcgcccg ggtacccgtg tatccaataa accctcttgc agttgcatcc gacttgtggt     5340

ctcgctgttc cttgggaggg tctcctctga gtgattgact acccgt                    5386


