                         SEQUENCE LISTING

<110>  ԴҽҩƼϺ޹˾
 
<120>  CD20CD3˫Կ弰;

<130>  2019

<150>  CN201811294887.4
<151>  2018-11-01

<160>  57    

<170>  PatentIn version 3.5

<210>  1
<211>  5
<212>  PRT
<213>  CD201 HCDR1

<400>  1

Ser Tyr Asn Met His 
1               5   


<210>  2
<211>  17
<212>  PRT
<213>  CD201 HCDR2

<400>  2

Ala Ile Tyr Pro Gly Asn Gly Asp Thr Ser Tyr Asn Gln Lys Phe Lys 
1               5                   10                  15      


Gly 
    


<210>  3
<211>  12
<212>  PRT
<213>  CD201 HCDR3

<400>  3

Ser Thr Tyr Tyr Gly Gly Asp Trp Tyr Phe Asn Val 
1               5                   10          


<210>  4
<211>  10
<212>  PRT
<213>  CD201 LCDR1

<400>  4

Arg Ala Ser Ser Ser Val Ser Tyr Ile His 
1               5                   10  


<210>  5
<211>  7
<212>  PRT
<213>  CD201 LCDR2

<400>  5

Ala Thr Ser Asn Leu Ala Ser 
1               5           


<210>  6
<211>  9
<212>  PRT
<213>  CD201 LCDR3

<400>  6

Gln Gln Trp Thr Ser Asn Pro Pro Thr 
1               5                   


<210>  7
<211>  5
<212>  PRT
<213>  CD202 HCDR1

<400>  7

Asn Tyr Tyr Ile His 
1               5   


<210>  8
<211>  17
<212>  PRT
<213>  CD202 HCDR2

<400>  8

Trp Ile Tyr Pro Gly Asp Gly Asn Thr Lys Tyr Asn Glu Lys Phe Lys 
1               5                   10                  15      


Gly 
    


<210>  9
<211>  10
<212>  PRT
<213>  CD202 HCDR3

<400>  9

Asp Ser Tyr Ser Asn Tyr Tyr Phe Asp Tyr 
1               5                   10  


<210>  10
<211>  10
<212>  PRT
<213>  CD202 LCDR1

<400>  10

Arg Ala Ser Ser Ser Val Ser Tyr Met His 
1               5                   10  


<210>  11
<211>  7
<212>  PRT
<213>  CD202 LCDR2

<400>  11

Ala Pro Ser Asn Leu Ala Ser 
1               5           


<210>  12
<211>  9
<212>  PRT
<213>  CD202 LCDR3

<400>  12

Gln Gln Trp Ser Phe Asn Pro Pro Thr 
1               5                   


<210>  13
<211>  5
<212>  PRT
<213>  CD203 HCDR1

<400>  13

Tyr Ser Trp Ile Asn 
1               5   


<210>  14
<211>  17
<212>  PRT
<213>  CD203 HCDR2

<400>  14

Arg Ile Phe Pro Gly Asp Gly Asp Thr Asp Tyr Asn Gly Lys Phe Lys 
1               5                   10                  15      


Gly 
    


<210>  15
<211>  10
<212>  PRT
<213>  CD203 HCDR3

<400>  15

Asn Val Phe Asp Gly Tyr Trp Leu Val Tyr 
1               5                   10  


<210>  16
<211>  16
<212>  PRT
<213>  CD203 LCDR1

<400>  16

Arg Ser Ser Lys Ser Leu Leu His Ser Asn Gly Ile Thr Tyr Leu Tyr 
1               5                   10                  15      


<210>  17
<211>  7
<212>  PRT
<213>  CD203 LCDR2

<400>  17

Gln Met Ser Asn Leu Val Ser 
1               5           


<210>  18
<211>  9
<212>  PRT
<213>  CD203 LCDR3

<400>  18

Ala Gln Asn Leu Glu Leu Pro Tyr Thr 
1               5                   


<210>  19
<211>  5
<212>  PRT
<213>  CD204 HCDR1

<400>  19

Asp Tyr Ala Met His 
1               5   


<210>  20
<211>  17
<212>  PRT
<213>  CD204 HCDR2

<400>  20

Thr Ile Ser Trp Asn Ser Gly Ser Ile Gly Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  21
<211>  13
<212>  PRT
<213>  CD204 HCDR3

<400>  21

Asp Ile Gln Tyr Gly Asn Tyr Tyr Tyr Gly Met Asp Val 
1               5                   10              


<210>  22
<211>  11
<212>  PRT
<213>  CD204 LCDR1

<400>  22

Arg Ala Ser Gln Ser Val Ser Ser Tyr Leu Ala 
1               5                   10      


<210>  23
<211>  7
<212>  PRT
<213>  CD204 LCDR2

<400>  23

Asp Ala Ser Asn Arg Ala Thr 
1               5           


<210>  24
<211>  9
<212>  PRT
<213>  CD204 LCDR3

<400>  24

Gln Gln Arg Ser Asn Trp Pro Ile Thr 
1               5                   


<210>  25
<211>  121
<212>  PRT
<213>  CD201ɱ

<400>  25

Gln Val Gln Leu Gln Gln Pro Gly Ala Glu Leu Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Met Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


Asn Met His Trp Val Lys Gln Thr Pro Gly Arg Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Ala Ile Tyr Pro Gly Asn Gly Asp Thr Ser Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Lys Gly Lys Ala Thr Leu Thr Ala Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Ser Thr Tyr Tyr Gly Gly Asp Trp Tyr Phe Asn Val Trp Gly 
            100                 105                 110         


Ala Gly Thr Thr Val Thr Val Ser Ala 
        115                 120     


<210>  26
<211>  106
<212>  PRT
<213>  CD201ɱ

<400>  26

Gln Ile Val Leu Ser Gln Ser Pro Ala Ile Leu Ser Ala Ser Pro Gly 
1               5                   10                  15      


Glu Lys Val Thr Met Thr Cys Arg Ala Ser Ser Ser Val Ser Tyr Ile 
            20                  25                  30          


His Trp Phe Gln Gln Lys Pro Gly Ser Ser Pro Lys Pro Trp Ile Tyr 
        35                  40                  45              


Ala Thr Ser Asn Leu Ala Ser Gly Val Pro Val Arg Phe Ser Gly Ser 
    50                  55                  60                  


Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile Ser Arg Val Glu Ala Glu 
65                  70                  75                  80  


Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Trp Thr Ser Asn Pro Pro Thr 
                85                  90                  95      


Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105     


<210>  27
<211>  119
<212>  PRT
<213>  CD202ɱ

<400>  27

Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asn Tyr 
            20                  25                  30          


Tyr Ile His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Trp Ile Tyr Pro Gly Asp Gly Asn Thr Lys Tyr Asn Glu Lys Phe 
    50                  55                  60                  


Lys Gly Arg Ala Thr Leu Thr Ala Asp Thr Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Leu Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Ser Tyr Ser Asn Tyr Tyr Phe Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser 
        115                 


<210>  28
<211>  106
<212>  PRT
<213>  CD202ɱ

<400>  28

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Ser Ser Val Ser Tyr Met 
            20                  25                  30          


His Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Pro Leu Ile Tyr 
        35                  40                  45              


Ala Pro Ser Asn Leu Ala Ser Gly Val Pro Ser Arg Phe Ser Gly Ser 
    50                  55                  60                  


Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu 
65                  70                  75                  80  


Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Trp Ser Phe Asn Pro Pro Thr 
                85                  90                  95      


Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105     


<210>  29
<211>  119
<212>  PRT
<213>  CD203ɱ

<400>  29

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Ala Phe Ser Tyr Ser 
            20                  25                  30          


Trp Ile Asn Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Arg Ile Phe Pro Gly Asp Gly Asp Thr Asp Tyr Asn Gly Lys Phe 
    50                  55                  60                  


Lys Gly Arg Val Thr Ile Thr Ala Asp Lys Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asn Val Phe Asp Gly Tyr Trp Leu Val Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser 
        115                 


<210>  30
<211>  112
<212>  PRT
<213>  CD203ɱ

<400>  30

Asp Ile Val Met Thr Gln Thr Pro Leu Ser Leu Pro Val Thr Pro Gly 
1               5                   10                  15      


Glu Pro Ala Ser Ile Ser Cys Arg Ser Ser Lys Ser Leu Leu His Ser 
            20                  25                  30          


Asn Gly Ile Thr Tyr Leu Tyr Trp Tyr Leu Gln Lys Pro Gly Gln Ser 
        35                  40                  45              


Pro Gln Leu Leu Ile Tyr Gln Met Ser Asn Leu Val Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Ala Gln Asn 
                85                  90                  95      


Leu Glu Leu Pro Tyr Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105                 110         


<210>  31
<211>  122
<212>  PRT
<213>  CD204ɱ

<400>  31

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asn Asp Tyr 
            20                  25                  30          


Ala Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Thr Ile Ser Trp Asn Ser Gly Ser Ile Gly Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Lys Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Leu Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Asp Ile Gln Tyr Gly Asn Tyr Tyr Tyr Gly Met Asp Val Trp 
            100                 105                 110         


Gly Gln Gly Thr Thr Val Thr Val Ser Ser 
        115                 120         


<210>  32
<211>  107
<212>  PRT
<213>  CD204ɱ

<400>  32

Glu Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Tyr 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile 
        35                  40                  45              


Tyr Asp Ala Ser Asn Arg Ala Thr Gly Ile Pro Ala Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Glu Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Arg Ser Asn Trp Pro Ile 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Arg Leu Glu Ile Lys 
            100                 105         


<210>  33
<211>  28
<212>  PRT
<213>  CTP: hCG £118-145

<400>  33

Ser Ser Ser Ser Lys Ala Pro Pro Pro Ser Leu Pro Ser Pro Ser Arg 
1               5                   10                  15      


Leu Pro Gly Pro Ser Asp Thr Pro Ile Leu Pro Gln 
            20                  25              


<210>  34
<211>  5
<212>  PRT
<213>  CD3 3 HCDR1

<400>  34

Thr Tyr Ala Met Asn 
1               5   


<210>  35
<211>  19
<212>  PRT
<213>  CD3 3 HCDR2

<400>  35

Arg Ile Arg Ser Lys Tyr Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp Ser 
1               5                   10                  15      


Val Lys Asp 
            


<210>  36
<211>  14
<212>  PRT
<213>  CD3 3 HCDR3

<400>  36

His Gly Asn Phe Gly Asn Ser Tyr Val Ser Trp Phe Ala Tyr 
1               5                   10                  


<210>  37
<211>  14
<212>  PRT
<213>  CD3 3 LCDR1

<400>  37

Arg Ser Ser Thr Gly Ala Val Thr Thr Ser Asn Tyr Ala Asn 
1               5                   10                  


<210>  38
<211>  7
<212>  PRT
<213>  CD3 3 LCDR2

<400>  38

Gly Thr Asn Lys Arg Ala Pro 
1               5           


<210>  39
<211>  9
<212>  PRT
<213>  CD3 3 LCDR3

<400>  39

Ala Leu Trp Tyr Ser Asn Leu Trp Val 
1               5                   


<210>  40
<211>  5
<212>  PRT
<213>  CD3 4 HCDR1

<400>  40

Lys Tyr Ala Met Asn 
1               5   


<210>  41
<211>  19
<212>  PRT
<213>  CD3 4 HCDR2

<400>  41

Arg Ile Arg Ser Lys Tyr Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp Ser 
1               5                   10                  15      


Val Lys Asp 
            


<210>  42
<211>  14
<212>  PRT
<213>  CD3 4 HCDR3

<400>  42

His Gly Asn Phe Gly Asn Ser Tyr Ile Ser Tyr Trp Ala Tyr 
1               5                   10                  


<210>  43
<211>  14
<212>  PRT
<213>  CD3 4 LCDR1

<400>  43

Gly Ser Ser Thr Gly Ala Val Thr Ser Gly Tyr Tyr Pro Asn 
1               5                   10                  


<210>  44
<211>  7
<212>  PRT
<213>  CD3 4 LCDR2

<400>  44

Gly Thr Lys Phe Leu Ala Pro 
1               5           


<210>  45
<211>  9
<212>  PRT
<213>  CD3 4 LCDR3

<400>  45

Ala Leu Trp Tyr Ser Asn Arg Trp Val 
1               5                   


<210>  46
<211>  125
<212>  PRT
<213>  CD3 3ɱ

<400>  46

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asn Thr Tyr 
            20                  25                  30          


Ala Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Arg Ile Arg Ser Lys Tyr Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp 
    50                  55                  60                  


Ser Val Lys Asp Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn Thr 
65                  70                  75                  80  


Ala Tyr Leu Gln Met Asn Asn Leu Lys Thr Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Val Arg His Gly Asn Phe Gly Asn Ser Tyr Val Ser Trp Phe 
            100                 105                 110         


Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125 


<210>  47
<211>  109
<212>  PRT
<213>  CD3 3ɱ

<400>  47

Glu Leu Val Val Thr Gln Glu Pro Ser Leu Thr Val Ser Pro Gly Gly 
1               5                   10                  15      


Thr Val Thr Leu Thr Cys Arg Ser Ser Thr Gly Ala Val Thr Thr Ser 
            20                  25                  30          


Asn Tyr Ala Asn Trp Val Gln Gln Lys Pro Gly Gln Ala Pro Arg Gly 
        35                  40                  45              


Leu Ile Gly Gly Thr Asn Lys Arg Ala Pro Gly Thr Pro Ala Arg Phe 
    50                  55                  60                  


Ser Gly Ser Leu Leu Gly Gly Lys Ala Ala Leu Thr Leu Ser Gly Val 
65                  70                  75                  80  


Gln Pro Glu Asp Glu Ala Glu Tyr Tyr Cys Ala Leu Trp Tyr Ser Asn 
                85                  90                  95      


Leu Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105                 


<210>  48
<211>  125
<212>  PRT
<213>  CD3 4ɱ

<400>  48

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asn Lys Tyr 
            20                  25                  30          


Ala Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Arg Ile Arg Ser Lys Tyr Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp 
    50                  55                  60                  


Ser Val Lys Asp Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn Thr 
65                  70                  75                  80  


Ala Tyr Leu Gln Met Asn Asn Leu Lys Thr Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Val Arg His Gly Asn Phe Gly Asn Ser Tyr Ile Ser Tyr Trp 
            100                 105                 110         


Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125 


<210>  49
<211>  109
<212>  PRT
<213>  CD3 4ɱ

<400>  49

Glu Leu Val Val Thr Gln Glu Pro Ser Leu Thr Val Ser Pro Gly Gly 
1               5                   10                  15      


Thr Val Thr Leu Thr Cys Gly Ser Ser Thr Gly Ala Val Thr Ser Gly 
            20                  25                  30          


Tyr Tyr Pro Asn Trp Val Gln Gln Lys Pro Gly Gln Ala Pro Arg Gly 
        35                  40                  45              


Leu Ile Gly Gly Thr Lys Phe Leu Ala Pro Gly Thr Pro Ala Arg Phe 
    50                  55                  60                  


Ser Gly Ser Leu Leu Gly Gly Lys Ala Ala Leu Thr Leu Ser Gly Val 
65                  70                  75                  80  


Gln Pro Glu Asp Glu Ala Glu Tyr Tyr Cys Ala Leu Trp Tyr Ser Asn 
                85                  90                  95      


Arg Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105                 


<210>  50
<211>  744
<212>  PRT
<213>  AP062

<400>  50

Gln Val Gln Leu Gln Gln Pro Gly Ala Glu Leu Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Met Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


Asn Met His Trp Val Lys Gln Thr Pro Gly Arg Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Ala Ile Tyr Pro Gly Asn Gly Asp Thr Ser Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Lys Gly Lys Ala Thr Leu Thr Ala Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Ser Thr Tyr Tyr Gly Gly Asp Trp Tyr Phe Asn Val Trp Gly 
            100                 105                 110         


Ala Gly Thr Thr Val Thr Val Ser Ala Gly Gly Gly Gly Ser Gly Gly 
        115                 120                 125             


Gly Gly Ser Gly Gly Gly Gly Ser Gln Ile Val Leu Ser Gln Ser Pro 
    130                 135                 140                 


Ala Ile Leu Ser Ala Ser Pro Gly Glu Lys Val Thr Met Thr Cys Arg 
145                 150                 155                 160 


Ala Ser Ser Ser Val Ser Tyr Ile His Trp Phe Gln Gln Lys Pro Gly 
                165                 170                 175     


Ser Ser Pro Lys Pro Trp Ile Tyr Ala Thr Ser Asn Leu Ala Ser Gly 
            180                 185                 190         


Val Pro Val Arg Phe Ser Gly Ser Gly Ser Gly Thr Ser Tyr Ser Leu 
        195                 200                 205             


Thr Ile Ser Arg Val Glu Ala Glu Asp Ala Ala Thr Tyr Tyr Cys Gln 
    210                 215                 220                 


Gln Trp Thr Ser Asn Pro Pro Thr Phe Gly Gly Gly Thr Lys Leu Glu 
225                 230                 235                 240 


Ile Lys Gly Gly Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
                245                 250                 255     


Gly Gly Ser Ser Ser Ser Ser Lys Ala Pro Pro Pro Ser Glu Val Gln 
            260                 265                 270         


Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Lys 
        275                 280                 285             


Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asn Thr Tyr Ala Met Asn 
    290                 295                 300                 


Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ala Arg Ile 
305                 310                 315                 320 


Arg Ser Lys Tyr Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp Ser Val Lys 
                325                 330                 335     


Asp Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn Thr Ala Tyr Leu 
            340                 345                 350         


Gln Met Asn Asn Leu Lys Thr Glu Asp Thr Ala Val Tyr Tyr Cys Val 
        355                 360                 365             


Arg His Gly Asn Phe Gly Asn Ser Tyr Val Ser Trp Phe Ala Tyr Trp 
    370                 375                 380                 


Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly 
385                 390                 395                 400 


Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Leu Val Val Thr Gln Glu 
                405                 410                 415     


Pro Ser Leu Thr Val Ser Pro Gly Gly Thr Val Thr Leu Thr Cys Arg 
            420                 425                 430         


Ser Ser Thr Gly Ala Val Thr Thr Ser Asn Tyr Ala Asn Trp Val Gln 
        435                 440                 445             


Gln Lys Pro Gly Gln Ala Pro Arg Gly Leu Ile Gly Gly Thr Asn Lys 
    450                 455                 460                 


Arg Ala Pro Gly Thr Pro Ala Arg Phe Ser Gly Ser Leu Leu Gly Gly 
465                 470                 475                 480 


Lys Ala Ala Leu Thr Leu Ser Gly Val Gln Pro Glu Asp Glu Ala Glu 
                485                 490                 495     


Tyr Tyr Cys Ala Leu Trp Tyr Ser Asn Leu Trp Val Phe Gly Gly Gly 
            500                 505                 510         


Thr Lys Leu Thr Val Leu Asp Lys Thr His Thr Cys Pro Pro Cys Pro 
        515                 520                 525             


Ala Pro Glu Ala Ala Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys 
    530                 535                 540                 


Pro Lys Asp Gln Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val 
545                 550                 555                 560 


Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr 
                565                 570                 575     


Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu 
            580                 585                 590         


Gln Tyr Ala Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His 
        595                 600                 605             


Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys 
    610                 615                 620                 


Ala Leu Pro Ala Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln 
625                 630                 635                 640 


Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu 
                645                 650                 655     


Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro 
            660                 665                 670         


Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn 
        675                 680                 685             


Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu 
    690                 695                 700                 


Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val 
705                 710                 715                 720 


Phe Ser Cys Ser Val Leu His Glu Ala Leu His Asn His Tyr Thr Gln 
                725                 730                 735     


Lys Ser Leu Ser Leu Ser Pro Gly 
            740                 


<210>  51
<211>  2232
<212>  DNA
<213>  AP062

<400>  51
caagtgcagc tgcagcagcc tggagctgag ctggtgaaac ccggcgcctc cgtcaagatg       60

tcctgtaagg cctccggata caccttcacc agctacaaca tgcactgggt gaaacagacc      120

cctggaaggg gcctggagtg gatcggcgcc atttaccctg gcaacggcga tacctcctat      180

aatcagaagt ttaagggcaa ggccaccctg accgctgata agagcagcag cacagcctac      240

atgcagctgt ccagcctgac ctccgaggac agcgccgtgt actactgtgc tcggagcacc      300

tactacggcg gcgactggta ctttaacgtg tggggagctg gcaccacagt gaccgtgagc      360

gccggaggag gaggatctgg aggaggaggc tccggaggag gaggaagcca gatcgtgctg      420

agccagagcc ccgccatcct gagcgccagc cccggcgaga aggtgaccat gacctgccgc      480

gccagcagca gcgtgagcta catccactgg ttccagcaga agcccggcag cagccccaag      540

ccctggatct acgccaccag caacctggcc agcggcgtgc ccgtgcgctt cagcggcagc      600

ggcagcggca ccagctacag cctgaccatc agccgcgtgg aggccgagga cgccgccacc      660

tactactgcc agcagtggac cagcaacccc cccaccttcg gcggcggcac caagctggag      720

atcaagggtg gcggcggtgg aggatccggc ggtggaggta gcggcggagg cggtagctcc      780

agctctagta aagctccccc tccttccgag gtgcagctgc tggagtccgg aggaggactg      840

gtgcagccag gaggctccct gaagctgagc tgtgctgcct ctggctttac cttcaacaca      900

tatgccatga attgggtgcg gcaggctcca ggcaagggac tggagtgggt ggctaggatc      960

aggtctaagt acaacaatta tgccacctac tatgctgatt ccgtgaagga caggttcacc     1020

atctcccgcg acgatagcaa gaacacagcc tacctgcaga tgaacaatct gaagaccgag     1080

gataccgccg tgtactactg cgtgagacat ggcaactttg gcaatagcta cgtgtcctgg     1140

ttcgcttact ggggacaggg caccctggtc acagtgagct ctggaggagg aggatctgga     1200

ggaggaggct ccggaggagg aggaagcgag ctggtggtga cccaggagcc atctctgaca     1260

gtgtcccccg gcggcacagt gaccctgaca tgtagatcca gcaccggcgc cgtgaccaca     1320

tccaactacg ctaattgggt gcagcagaag ccaggacagg ctccaagggg actgatcgga     1380

ggaaccaaca agagggctcc tggaacacca gctcggttta gcggatctct gctgggaggc     1440

aaggctgccc tgaccctgtc cggagtgcag ccagaggatg aggccgagta ttattgcgct     1500

ctgtggtata gcaatctgtg ggtgttcgga ggaggaacca agctgacagt gctggacaag     1560

acccatacat gcccaccatg ccctgcccct gaagccgccg gaggaccttc cgtgttcctg     1620

ttccctccca agccaaaaga tcagctgatg atctctagaa cccccgaagt cacctgcgtg     1680

gtcgtcgacg tgtcccatga ggaccctgaa gtcaagttca actggtacgt ggacggtgtc     1740

gaagtccaca acgccaagac caagcctagg gaggagcagt atgccagcac ataccgggtg     1800

gtgtctgtgc tgaccgtgct gcatcaggat tggctgaatg gcaaggaata taaatgtaag     1860

gtgagcaata aggctctgcc ggctagcatt gaaaaaacca tttccaaggc taagggccag     1920

cccagggagc ctcaggtcta caccctgcct ccatctagag atgaactgac caaaaaccag     1980

gtgagcctga cttgcctggt caaaggcttc taccccagcg acattgccgt ggagtgggag     2040

tctaatggcc agcctgaaaa taactacaaa actacccctc ctgtgctgga ctctgatggc     2100

tccttctttc tgtactctaa actgaccgtg gacaagtctc gctggcagca gggtaacgtg     2160

ttttcttgct ccgtgctgca cgaggctctg cataaccatt acacccagaa gagcctgtct     2220

ctgtccccag ga                                                         2232


<210>  52
<211>  27
<212>  PRT
<213>  G2(GGGGS)3CTP1

<400>  52

Gly Gly Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
1               5                   10                  15      


Ser Ser Ser Ser Ser Lys Ala Pro Pro Pro Ser 
            20                  25          


<210>  53
<211>  25
<212>  PRT
<213>  (GGGGS)3CTP1

<400>  53

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ser 
1               5                   10                  15      


Ser Ser Ser Lys Ala Pro Pro Pro Ser 
            20                  25  


<210>  54
<211>  22
<212>  PRT
<213>  GS(GGGGS)2CTP1

<400>  54

Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ser Ser Ser Ser 
1               5                   10                  15      


Lys Ala Pro Pro Pro Ser 
            20          


<210>  55
<211>  33
<212>  PRT
<213>  (GGGGS)1CTP4

<400>  55

Gly Gly Gly Gly Ser Ser Ser Ser Ser Lys Ala Pro Pro Pro Ser Leu 
1               5                   10                  15      


Pro Ser Pro Ser Arg Leu Pro Gly Pro Ser Asp Thr Pro Ile Leu Pro 
            20                  25                  30          


Gln 
    


<210>  56
<211>  227
<212>  PRT
<213>  IgG1 Fc(L234A,L235A)ͻ㶨

<400>  56

Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Ala Ala Gly 
1               5                   10                  15      


Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 
            20                  25                  30          


Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His 
        35                  40                  45              


Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val 
    50                  55                  60                  


His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr 
65                  70                  75                  80  


Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly 
                85                  90                  95      


Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile 
            100                 105                 110         


Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val 
        115                 120                 125             


Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser 
    130                 135                 140                 


Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 
145                 150                 155                 160 


Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro 
                165                 170                 175     


Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val 
            180                 185                 190         


Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met 
        195                 200                 205             


His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser 
    210                 215                 220                 


Pro Gly Lys 
225         


<210>  57
<211>  226
<212>  PRT
<213>  IgG1(L234A,L235A, T250Q,N297A,P331S,M428L,K447-)ͻ㶨

<400>  57

Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Ala Ala Gly 
1               5                   10                  15      


Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Gln Leu Met 
            20                  25                  30          


Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His 
        35                  40                  45              


Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val 
    50                  55                  60                  


His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Ala Ser Thr Tyr 
65                  70                  75                  80  


Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly 
                85                  90                  95      


Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Ser Ile 
            100                 105                 110         


Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val 
        115                 120                 125             


Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser 
    130                 135                 140                 


Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 
145                 150                 155                 160 


Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro 
                165                 170                 175     


Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val 
            180                 185                 190         


Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Leu 
        195                 200                 205             


His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser 
    210                 215                 220                 


Pro Gly 
225     


